title: Takotsubo cardiomyopathy: reversible elevation in microcirculatory resistance.
abstract: We present a case of takotsubo cardiomyopathy and demonstrate an initial elevation of microcirculatory resistance (IMR) that reduced on follow-up evaluation. This corresponded with improvements in left ventricular function. We postulate that the changes in microvascular resistance reflect favourable left ventricular microvascular remodelling. The measurement of IMR, a novel marker of microcirculatory dysfunction, provides novel insights into the pathophysiology of this condition.
authors.affiliation: Department of Cardiology, St Vincent's Hospital, Melbourne, Victoria, Australia. jamielayland@hotmail.com
authors.forename: Jamie
authors.initials: J
authors.lastname: Layland
authors.forename: Robert
authors.initials: R
authors.lastname: Whitbourn
authors.forename: Andrew
authors.initials: A
authors.lastname: Macisaac
authors.forename: Jithendra
authors.initials: J
authors.lastname: Somaratne
authors.forename: Andrew
authors.initials: A
authors.lastname: Wilson
mesh_terms: D003326:Coronary Circulation / Q000502:physiology*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008833:Microcirculation / Q000502:physiology*; D008875:Middle Aged; D054549:Takotsubo Cardiomyopathy / Q000503:physiopathology*; D014655:Vascular Resistance; D016277:Ventricular Function, Left / Q000502:physiology*