title: Insulin-like growth factor: current concepts and new developments in cancer therapy.
abstract: The insulin-like growth factor (IGF) family and the IGF-1 receptor (IGF-1R) play an important role in cancer. This intricate and complex signaling pathway provides many opportunities for therapeutic intervention, and several novel therapeutics aimed at the IGF-1R, particularly monoclonal antibodies and small molecule tyrosine kinase inhibitors, are under clinical investigation. This article provides a patent overview of the IGF signaling pathway and its complexity, addresses the justification for the use of IGF-1R-targeted therapy, and reviews the results of in vivo and in vitro novel therapeutics. Over the past year, the completion of several phase I, II, and III trials have provided interesting new information about the clinical activity of these novel compounds, particularly CP-751,871, IMC-A12, R1507, AMG-479, AVE-1642, MK-0646, XL-228, OSI-906, and BMS-754807. We review the important preliminary results from clinical trials with these compounds and conclude with a discussion about future therapeutic efforts.
authors.affiliation: Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Unit 1362, 1515 Holcombe Boulevard, Houston, Texas 77030, USA. kkwong@mdanderson.org
authors.forename: Erin R
authors.initials: ER
authors.lastname: King
authors.forename: Kwong-Kwok
authors.initials: KK
authors.lastname: Wong
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D002986:Clinical Trials as Topic / Q000639:trends; D055808:Drug Discovery / Q000639:trends*; D006801:Humans; D009369:Neoplasms / Q000201:enzymology / Q000276:immunology* / Q000628:therapy*; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D017451:Receptors, Somatomedin / Q000037:antagonists & inhibitors* / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D013002:Somatomedins / Q000037:antagonists & inhibitors* / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D047428:Protein Kinase Inhibitors; D017451:Receptors, Somatomedin; D013002:Somatomedins