title: Computation of bone remodelling after Duracon knee arthroplasty using a thermodynamic-based model.
abstract: The present study utilizes a recently developed literature model for the bone remodelling process to predict the evolution of bone density following Duracon total knee arthroplasty (TKA). In this model, which is based on chemical kinetics and irreversible thermodynamics, bone is treated as a self-organizing system capable of exchanging matter, energy, and entropy with its surroundings. Unlike previous models in which mechanical loading is regarded as the only stimulus for bone remodelling, the present model establishes a unique coupling between mechanical loading and the chemical reactions involved in the process of bone remodelling. This model was incorporated into the finite element software ANSYS by means of a macro to compute density distribution in distal femoral bone both before and after TKA. Consistent with dual-energy X-ray absorptiometry (DEXA) scans reported in the literature, the results showed that the most severe bone loss occurs in the anterior region of the distal femur and that there is more bone resorption in the lateral than the medial condyle following TKA. Furthermore, the bone density distribution predicted using the present model showed a gradual and uniform pattern and thus a more realistic bone evolution contrary to the strain energy density model, where there is no gradual bone density evolution.
authors.affiliation: Department of Mechanical and Industrial Engineering, Ryerson University, Toronto, Ontario, Canada. habiba.bougherara@ryerson.ca
authors.forename: H
authors.initials: H
authors.lastname: Bougherara
authors.forename: S
authors.initials: S
authors.lastname: Nazgooei
authors.forename: A
authors.initials: A
authors.lastname: Sayyidmousavi
authors.forename: F
authors.initials: F
authors.lastname: Marsik
authors.forename: I A
authors.initials: IA
authors.lastname: Marík
mesh_terms: D019645:Arthroplasty, Replacement, Knee; D001696:Biomechanical Phenomena; D001698:Biomedical Engineering; D015519:Bone Density; D016723:Bone Remodeling / Q000502:physiology*; D017076:Computer-Aided Design; D005269:Femur / Q000000981:diagnostic imaging / Q000502:physiology / Q000601:surgery; D020342:Finite Element Analysis; D006801:Humans; D008954:Models, Biological; D011859:Radiography; D013816:Thermodynamics