title: Induction of fertile oestrus in the bitch using Deslorelin, a GnRH agonist.
abstract: Oestrus induction in various canine breeds was attempted in 32 bitches. A group of 8 bitches were treated 80-160 d following their previous oestrus (G1) whereas a second group of 24 bitches (G2) were implanted 200-590 d following their previous oestrus. The treatment for each bitch consisted in one Deslorelin implant (Suprelorin® 4,7 mg, Virbac, France), inserted subcutaneously in the post-umbilical region. Ovulation, pregnancy rate and litter size were recorded. All bitches came in heat 4.3 ± 1.4 d after implantation (2-7 d). Ovulation was reported in 62.5% in G1 and 87.5% in G2. One bitch refused mating and since no AI was performed, she was not considered for further analysis. Pregnancy was obtained in 25% in G1 versus 78.3% in G2. Mean litter size was 6.7 ± 3.5 puppies (1-14). Luteal failure was suspected in 3 bitches, two that remained non-pregnant and one which aborted 58 d post-ovulation since the owner refused progesterone supplementation. Deslorelin implants can therefore be considered as a valuable alternative to induce fertile oestrus in bitches in anoestrus. Follow-up of the luteal phase is recommended, since some bitches might encounter luteal failure.
authors.affiliation: Centre d'Etudes en Reproduction des Carnivores (CERCA), Ecole Nationale Vétérinaire d'Alfort, Paris, France. efontaine@vet-alfort.fr
authors.forename: E
authors.initials: E
authors.lastname: Fontaine
authors.forename: F
authors.initials: F
authors.lastname: Mir
authors.forename: F
authors.initials: F
authors.lastname: Vannier
authors.forename: A
authors.initials: A
authors.lastname: Gérardin
authors.forename: M
authors.initials: M
authors.lastname: Albouy
authors.forename: C
authors.initials: C
authors.lastname: Navarro
authors.forename: A
authors.initials: A
authors.lastname: Fontbonne
mesh_terms: D000818:Animals; D004285:Dogs; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D004971:Estrus / Q000187:drug effects*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D010060:Ovulation / Q000187:drug effects; D011247:Pregnancy; D019736:Prostheses and Implants; D017329:Triptorelin Pamoate / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone; C066438:deslorelin