title: A synthetic approach to kingianin A based on biosynthetic speculation.
abstract: A synthetic approach towards the structurally complex dimer, kingianin A is reported. The strategy involved a cascade of complexity generating reactions, inspired through biosynthetic speculation. A concise protecting group free synthesis of the proposed monomeric precursor pre-kingianin A has been achieved using a tandem Stille cross-coupling reaction and electrocyclisation process. However, preliminary studies of the key dimerisation reaction have been conducted, which indicate that the process is not spontaneous, raising questions as to the origin of this complex natural product.
authors.affiliation: School of Chemistry, University of Nottingham, Nottingham, UK.
authors.forename: Pallavi
authors.initials: P
authors.lastname: Sharma
authors.forename: Dougal J
authors.initials: DJ
authors.lastname: Ritson
authors.forename: James
authors.initials: J
authors.lastname: Burnley
authors.forename: John E
authors.initials: JE
authors.lastname: Moses
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry / Q000378:metabolism; D003500:Cyclization; D019281:Dimerization; D010084:Oxidation-Reduction; D011084:Polycyclic Aromatic Hydrocarbons / Q000737:chemistry / Q000378:metabolism*
chemical_list: D011084:Polycyclic Aromatic Hydrocarbons; C553350:kingianin A