title: Superabsorbent polymer-containing wound dressings have a beneficial effect on wound healing by reducing PMN elastase concentration and inhibiting microbial growth.
abstract: A comprehensive in vitro approach was used to assess the effects of superabsorbent polymer (SAP) containing wound dressings in treatment of non-healing wounds. A slight negative effect on HaCaT cells was noted in vitro which is most likely due to the Ca(2+) deprivation of the medium by binding to the SAP. It could be shown that SAP wound dressings are able to bind considerable amounts of elastase reducing enzyme activity significantly. Furthermore, SAP's inhibit the formation of free radicals. The SAP-containing wound dressings tested also exhibited a significant to strong antimicrobial activity effectively impeding the growth of gram-negative and gram-positive bacteria as well as yeasts. In conclusion, in vitro data confirm the positive effect of SAP wound dressings observed in vivo and suggest that they should be specifically useful for wound cleansing.
authors.affiliation: Department of Dermatology, University Medical Center, Erfurter Str. 34, 07740 Jena, Germany. C.Wiegand@med.uni-jena.de
authors.forename: C
authors.initials: C
authors.lastname: Wiegand
authors.forename: M
authors.initials: M
authors.lastname: Abel
authors.forename: P
authors.initials: P
authors.lastname: Ruth
authors.forename: U C
authors.initials: UC
authors.lastname: Hipler
mesh_terms: D000042:Absorption; D000180:Acrylic Resins / Q000737:chemistry*; D000900:Anti-Bacterial Agents; D001458:Bandages; D001672:Biocompatible Materials; D002460:Cell Line; D006801:Humans; D019272:Leukocyte Elastase / Q000378:metabolism*; D008422:Materials Testing; D011108:Polymers / Q000737:chemistry*; D014945:Wound Healing
chemical_list: D000180:Acrylic Resins; D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D011108:Polymers; C006903:carbopol 940; D019272:Leukocyte Elastase