title: Preliminary report on the expression of leptin and leptin receptor (ObR) in normal, hyperplastic and neoplastic canine mammary tissues.
abstract: Leptin and its receptor (ObR) expression were investigated by immunohistochemistry in normal, hyperplastic and neoplastic canine mammary tissues and related to clinical-pathological features. Leptin expression was detected in healthy mammary tissues, adenosis and in benign mammary tumours and was lower in ductal hyperplasias and malignant tumours. A high percentage of ObR-positive cells were present in adenosis, benign tumours and in complex carcinomas, while ObR expression was lower in healthy mammary tissues, in ductal hyperplasias and in a large part of invasive mammary carcinomas. Our data demonstrated that cancer cells expressed at low level leptin and ObR in canine mammary tumours with a more aggressive behaviour, as well as in lymph node metastases. Consequently, leptin and ObR expressions in this species resulted to be not associated with a reduced overall survival.
authors.affiliation: Department of Animal Pathology, School of Veterinary Medicine, University of Pisa, Pisa I-56124, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Ressel
authors.forename: Riccardo
authors.initials: R
authors.lastname: Finotello
authors.forename: Viola Maria
authors.initials: VM
authors.lastname: Innocenti
authors.forename: Iacopo
authors.initials: I
authors.lastname: Vannozzi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Poli
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000378:metabolism* / Q000473:pathology; D004285:Dogs; D005260:Female; D006965:Hyperplasia / Q000378:metabolism / Q000662:veterinary; D020738:Leptin / Q000032:analysis / Q000096:biosynthesis*; D008321:Mammary Glands, Animal / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology; D015674:Mammary Neoplasms, Animal / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology; D054411:Receptors, Leptin / Q000032:analysis / Q000096:biosynthesis*
chemical_list: D020738:Leptin; D054411:Receptors, Leptin