title: Whole blood transfusion in the treatment of an acute organophosphorus poisoning--a case report.
abstract: BACKGROUND
  Organophosphorus compounds (OP) are a group of substances used in agriculture as pesticides and are also used as military poisoning agents (MPA). Intoxication by these agents may cause severe systemic disturbances related to both the exposure time and lethal agent concentration. Toxic effects result from an excess of the endogenous neurotransmitter, acetylcholine (ACh), because decomposition of Ach by cholinesterases is blocked by OP.
  
  
  METHODS
  The authors describe a case in which an acute OP poisoning was managed both conventionally and with cholinesterase substitution by blood transfusion.
  
  
  CONCLUSIONS
  Whole blood transfusion could be beneficial in the treatment of these life-threatening medical conditions.
authors.affiliation: Department of Anaesthesiology and Intensive Therapy, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Stan
authors.initials: S
authors.lastname: Ryniak
authors.forename: Piotr
authors.initials: P
authors.lastname: Harbut
authors.forename: Waldemar
authors.initials: W
authors.lastname: Goździk
authors.forename: Janusz
authors.initials: J
authors.lastname: Sokołowski
authors.forename: Przemysław
authors.initials: P
authors.lastname: Paciorek
authors.forename: Joanna
authors.initials: J
authors.lastname: Hałas
mesh_terms: D000293:Adolescent; D001803:Blood Transfusion; D002802:Cholinesterases / Q000378:metabolism; D006801:Humans; D008297:Male; D062025:Organophosphate Poisoning; D010278:Parathion / Q000506:poisoning; D010575:Pesticides / Q000506:poisoning
chemical_list: D010575:Pesticides; D010278:Parathion; D002802:Cholinesterases