title: A new strategy for estimating two-locus recombination fractions under some natural inequality restrictions.
abstract: Linkage analysis is now being widely used to map markers on each chromosome in the human genome, to map genetic diseases, and to identify genetic forms of common diseases. Two-locus linkage analysis and multi-locus analysis have been investigated comprehensively, and many computer programs have been developed to perform linkage analysis. Yet there exists a shortcoming in traditional methods, i.e., the parameter space of two-locus recombination fractions has not been emphasized sufficiently in the usual analyses. In this paper, we propose a new strategy for estimating the two-locus recombination fractions based on data of backcross family in the framework of some natural and necessary parameter restrictions. The new strategy is based on a restricted projection algorithm, which can provide fast reasonable estimates of recombination fraction, and can therefore serve as a superior alternative algorithm. Results obtained from both real and simulated data indicate that the new algorithm performs well in the estimation of recombination fractions and outperforms current methods.
authors.affiliation: School of Mathematical Sciences, Heilongjiang University, Harbin 150080, People's Republic of China. zhouy577@yahoo.com.cn
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhou
authors.forename: Weijun
authors.initials: W
authors.lastname: Ma
authors.forename: Xiaona
authors.initials: X
authors.lastname: Sheng
authors.forename: Huakun
authors.initials: H
authors.lastname: Wang
mesh_terms: D000465:Algorithms; D000818:Animals; D002874:Chromosome Mapping / Q000379:methods*; D003198:Computer Simulation; D008040:Genetic Linkage; D006801:Humans; D016013:Likelihood Functions; D008957:Models, Genetic