title: Tuberculosis drug development: ensuring people living with HIV are not left behind.
abstract: An unprecedented number of new tuberculosis (TB) medications are currently in development, and there will be great pressure to deploy these new drugs among all populations after their efficacy is demonstrated. People living with HIV experience a large burden of TB and have a particularly pressing need for TB treatments that are shorter and less toxic. In addition, all people living with HIV now require antiretroviral therapy during TB treatment. A roadmap of the research, programmatic, and regulatory considerations includes the following: (1) inclusion of people living with HIV early in clinical trials for treatment and prevention using new TB medications, (2) prioritization of key studies of HIV-TB drug interactions and interactions between new TB agents, and (3) optimization of clinical trial infrastructure, laboratory capacity, and drug susceptibility testing.
authors.affiliation: HIV/AIDS Division, San Francisco General Hospital, University of California, San Francisco, CA 94110, USA. aluetkemeyer@php.ucsf.edu
authors.forename: Anne F
authors.initials: AF
authors.lastname: Luetkemeyer
authors.forename: Haileyesus
authors.initials: H
authors.lastname: Getahun
authors.forename: Gabriel
authors.initials: G
authors.lastname: Chamie
authors.forename: Christian
authors.initials: C
authors.lastname: Lienhardt
authors.forename: Diane V
authors.initials: DV
authors.lastname: Havlir
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic / Q000379:methods; D060085:Coinfection / Q000188:drug therapy; D055808:Drug Discovery; D004347:Drug Interactions; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000188:drug therapy* / Q000517:prevention & control
chemical_list: D019380:Anti-HIV Agents; D000995:Antitubercular Agents