title: Tumour diameter and decreased preoperative estimated glomerular filtration rate are independently correlated in patients with renal cell carcinoma.
abstract: OBJECTIVE
  To examine the relationship between tumour diameter and estimated GFR (eGFR) in patients with renal cell carcinoma (RCC).
  
  
  METHODS
  In total, 1009 patients undergoing partial or radical nephrectomy for unilateral RCC were identified in the Columbia Urologic Database. eGFR was calculated using the modification of diet in renal disease equation using demographic data and preoperative serum creatinine values. Data on patient demographics, tumour characteristics, and comorbidities were analyzed using univariate and multivariate regression analysis.
  
  
  RESULTS
  Mean (sd, range) tumour diameter was 5.29 (3.8, 0.3-29) cm. Mean (sd, range) eGFR was 75 (23.4, 3-173) mL/min per 1.73 m(2) . In multivariate regression analysis, tumour diameter independently predicted decreased preoperative eGFR (coefficient, -0.513; P= 0.008) when controlling for hypertension and race. Consistent with this, decreased preoperative eGFR independently predicted increased tumour diameter (coefficient, -0.013; P= 0.007) when controlling for race, histology and smoking status.
  
  
  CONCLUSIONS
  Tumour diameter and decreased preoperative eGFR are independently correlated in patients with RCC.
authors.affiliation: Department of Urology, Columbia University College of Physicians and Surgeons, Herbert Irving Comprehensive Cancer Center, New York, NY 10032, USA. donin@post.harvard.edu
authors.forename: Nicholas M
authors.initials: NM
authors.lastname: Donin
authors.forename: Lara K
authors.initials: LK
authors.lastname: Suh
authors.forename: LaMont
authors.initials: L
authors.lastname: Barlow
authors.forename: Gregory W
authors.initials: GW
authors.lastname: Hruby
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Newhouse
authors.forename: James
authors.initials: J
authors.lastname: McKiernan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000503:physiopathology*; D007680:Kidney Neoplasms / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D012189:Retrospective Studies; D047368:Tumor Burden / Q000502:physiology*