title: [Effect of mexidol on combined vascular pathology of brain and heart].
abstract: The effect of mexidol on cerebral blood flow under conditions of experimental myocardial infarction and combined disturbances of cerebral and coronary perfusion in comparison with intact and false-operated rats and rats after global transient ischemia of brain was studied. It is established that mexidol (200 mg/kg) more prominently enhances the blood flow in the parietal region of brain cortex of rats with combined ischemia of brain and heart as compared to intact rats and rats after experimental myocardial infarction. Under conditions of combined pathology, mexidol produces the same cerebrovascular effect as that in animals with cerebral ischemia.
authors.forename: A V
authors.initials: AV
authors.lastname: Gnezdilova
authors.forename: M A
authors.initials: MA
authors.lastname: Lebedeva
authors.forename: T S
authors.initials: TS
authors.lastname: Gan'shina
authors.forename: R S
authors.initials: RS
authors.lastname: Mirzoian
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D054059:Coronary Occlusion / Q000150:complications / Q000503:physiopathology*; D004195:Disease Models, Animal; D002546:Ischemic Attack, Transient / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D010296:Parietal Lobe / Q000098:blood supply / Q000503:physiopathology; D010847:Picolines / Q000008:administration & dosage* / Q000627:therapeutic use; D051381:Rats
chemical_list: D018696:Neuroprotective Agents; D010847:Picolines; C070020:emoxypine succinate