title: Sterostreins A-E, new terpenoids from cultures of the Basidiomycete Stereum ostrea BCC 22955.
abstract: Sterostreins A-E (1, 2, 3a/3b, 4, and 5), five novel terpenoids, were isolated from cultures of the mushroom fungus Stereum ostrea BCC 22955. Sterostrein A (1) exhibited antimalarial activity (IC(50) 2.3 μg/mL) and cytotoxicity (IC(50) 5.3-38 μg/mL).
authors.affiliation: National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand. isaka@biotec.or.th
authors.forename: Masahiko
authors.initials: M
authors.lastname: Isaka
authors.forename: Urarat
authors.initials: U
authors.lastname: Srisanoh
authors.forename: Wilunda
authors.initials: W
authors.lastname: Choowong
authors.forename: Thitiya
authors.initials: T
authors.lastname: Boonpratuang
mesh_terms: D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005658:Fungi / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007624:KB Cells; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D010963:Plasmodium falciparum / Q000187:drug effects*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000962:Antimalarials; D013729:Terpenes