title: Use of preimplantation genetic diagnosis and preimplantation genetic screening in the United States: a Society for Assisted Reproductive Technology Writing Group paper.
abstract: OBJECTIVE
  To comprehensively report Society for Assisted Reproductive Technology (SART) member program usage of preimplantation genetic testing (PGT), preimplantation genetic diagnosis (PGD) for diagnosis of specific conditions, and preimplantation genetic screening for aneuploidy (PGS).
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  United States SART cohort data.
  
  
  METHODS
  Women undergoing a PGT cycle in which at least one embryo underwent biopsy.
  
  
  METHODS
  PGT.
  
  
  METHODS
  PGT use, indications, and delivery rates.
  
  
  RESULTS
  Of 190,260 fresh, nondonor assisted reproductive technology (ART) cycles reported to SART CORS in 2007-2008, 8,337 included PGT. Of 6,971 cycles with a defined indication, 1,382 cycles were for genetic diagnosis, 3,645 for aneuploidy screening (PGS), 527 for translocation, and 1,417 for elective sex election. Although the total number of fresh, autologous cycles increased by 3.6% from 2007 to 2008, the percentage of cycles with PGT decreased by 5.8% (4,293 in 2007 and 4,044 in 2008). As a percentage of fresh, nondonor ART cycles, use dropped from 4.6% (4,293/93,433) in 2007 to 4.2% (4,044/96,827) in 2008. The primary indication for PGT was PGS: cycles performed for this indication decreased (-8.0%). PGD use for single-gene defects (+3.2%), elective sex selection (+5.3%), and translocation analysis (+0.5%) increased. PGT usage varied significantly by geographical region.
  
  
  CONCLUSIONS
  PGT usage in the United States decreased between 2007 and 2008 owing to a decrease in PGS. Use of elective sex selection increased. High transfer cancellation rates correlated with reduced live-birth rates for some PGT indications.
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. eginsburg@partners.org
authors.forename: Elizabeth S
authors.initials: ES
authors.lastname: Ginsburg
authors.forename: Valerie L
authors.initials: VL
authors.lastname: Baker
authors.forename: Catherine
authors.initials: C
authors.lastname: Racowsky
authors.forename: Ethan
authors.initials: E
authors.lastname: Wantman
authors.forename: James
authors.initials: J
authors.lastname: Goldfarb
authors.forename: Judy E
authors.initials: JE
authors.lastname: Stern
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D005820:Genetic Testing / Q000706:statistics & numerical data* / Q000639:trends; D006801:Humans; D011247:Pregnancy; D019836:Preimplantation Diagnosis / Q000706:statistics & numerical data* / Q000639:trends; D027724:Reproductive Techniques, Assisted / Q000706:statistics & numerical data* / Q000639:trends; D012189:Retrospective Studies; D012955:Societies, Medical; D014481:United States