title: Mitochondrial calcium handling during ischemia-induced cell death in neurons.
abstract: Mitochondria sense and shape cytosolic Ca(2+) signals by taking up and subsequently releasing Ca(2+) ions during physiological and pathological Ca(2+) elevations. Sustained elevations in the mitochondrial matrix Ca(2+) concentration are increasingly recognized as a defining feature of the intracellular cascade of lethal events that occur in neurons during cerebral ischemia. Here, we review the recently identified transport proteins that mediate the fluxes of Ca(2+) across mitochondria and discuss the implication of the permeability transition pore in decoding the abnormally sustained mitochondrial Ca(2+) elevations that occur during cerebral ischemia.
authors.affiliation: Department of Cell Physiology and Metabolism, University of Geneva, rue Michel-Servet 1, Genève, Switzerland.
authors.forename: Yves
authors.initials: Y
authors.lastname: Gouriou
authors.forename: Nicolas
authors.initials: N
authors.lastname: Demaurex
authors.forename: Philippe
authors.initials: P
authors.lastname: Bijlenga
authors.forename: Umberto
authors.initials: U
authors.lastname: De Marchi
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D002118:Calcium / Q000378:metabolism*; D002135:Calcium-Binding Proteins; D016923:Cell Death; D015687:Cell Hypoxia; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D033681:Mitochondrial Membrane Transport Proteins / Q000378:metabolism; D000083162:Mitochondrial Permeability Transition Pore; D009474:Neurons / Q000378:metabolism* / Q000473:pathology
chemical_list: D002135:Calcium-Binding Proteins; D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D002118:Calcium