title: Review of juxtaglomerular cell tumor with focus on pathobiological aspect.
abstract: Juxtaglomerular cell tumor (JGCT) generally affects adolescents and young adults. The patients experience symptoms related to hypertension and hypokalemia due to renin-secretion by the tumor. Grossly, the tumor is well circumscribed with fibrous capsule and the cut surface shows yellow or gray-tan color with frequent hemorrhage. Histologically, the tumor is composed of monotonous polygonal cells with entrapped normal tubules. Immunohistochemically, tumor cells exhibit a positive reactivity for renin, vimentin and CD34. Ultrastructurally, neoplastic cells contain rhomboid-shaped renin protogranules. Genetically, losses of chromosomes 9 and 11 were frequently observed. Clinically, the majority of tumors showed a benign course, but rare tumors with vascular invasion or metastasis were reported. JGCT is a curable cause of hypertensive disease if it is discovered early and surgically removed, but may cause a fatal outcome usually by a cerebrovascular attack or may cause fetal demise in pregnancy. Additionally, pathologists and urologists need to recognize that this neoplasm in most cases pursues a benign course, but aggressive forms may develop in some cases.
authors.affiliation: Department of Diagnostic Pathology, Kochi Red Cross Hospital, Shin-honmachi 2-13-51, Kochi City, Kochi 780-8562, Japan. kurochankochi@yahoo.co.jp
authors.forename: Naoto
authors.initials: N
authors.lastname: Kuroda
authors.forename: Hiroko
authors.initials: H
authors.lastname: Gotoda
authors.forename: Chisato
authors.initials: C
authors.lastname: Ohe
authors.forename: Shuji
authors.initials: S
authors.lastname: Mikami
authors.forename: Keiji
authors.initials: K
authors.lastname: Inoue
authors.forename: Yoji
authors.initials: Y
authors.lastname: Nagashima
authors.forename: Fredrik
authors.initials: F
authors.lastname: Petersson
authors.forename: Isabel
authors.initials: I
authors.lastname: Alvarado-Cabrero
authors.forename: Chin-Chen
authors.initials: CC
authors.lastname: Pan
authors.forename: Ondrej
authors.initials: O
authors.lastname: Hes
authors.forename: Michal
authors.initials: M
authors.lastname: Michal
authors.forename: Zoran
authors.initials: Z
authors.lastname: Gatalica
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D007606:Juxtaglomerular Apparatus / Q000473:pathology* / Q000601:surgery; D007680:Kidney Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D011237:Predictive Value of Tests; D011379:Prognosis