title: Antiviral TRIMs: friend or foe in autoimmune and autoinflammatory disease?
abstract: The concept that viral sensing systems, via their ability to drive pro-inflammatory cytokine and interferon production, contribute to the development of autoimmune and autoinflammatory disease is supported by a wide range of clinical and experimental observations. Recently, the tripartite motif-containing proteins (TRIMs) have emerged as having key roles in antiviral immunity - either as viral restriction factors or as regulators of pathways downstream of viral RNA and DNA sensors, and the inflammasome. Given their involvement in these pathways, we propose that TRIM proteins contribute to the development and pathology of autoimmune and autoinflammatory conditions, thus making them potential novel targets for therapeutic manipulation.
authors.affiliation: Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland. cjefferies@rcsi.ie
authors.forename: Caroline
authors.initials: C
authors.lastname: Jefferies
authors.forename: Claire
authors.initials: C
authors.lastname: Wynne
authors.forename: Rowan
authors.initials: R
authors.lastname: Higgs
mesh_terms: D000818:Animals; D000090103:Antiviral Restriction Factors; D001327:Autoimmune Diseases / Q000276:immunology* / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D056660:Hereditary Autoinflammatory Diseases / Q000276:immunology*; D006801:Humans; D058847:Inflammasomes / Q000276:immunology*; D007372:Interferons / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D015778:Minor Histocompatibility Antigens; D054829:RING Finger Domains; D012097:Repressor Proteins / Q000378:metabolism; D012261:Ribonucleoproteins / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic; D000070584:Tripartite Motif Proteins; D000076183:Tripartite Motif-Containing Protein 28; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*; D014780:Viruses / Q000276:immunology*; D000099207:SS-A Antigen
chemical_list: D000090103:Antiviral Restriction Factors; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D058847:Inflammasomes; D007372:Interferons; D015778:Minor Histocompatibility Antigens; D012097:Repressor Proteins; D012261:Ribonucleoproteins; D014157:Transcription Factors; D000070584:Tripartite Motif Proteins; D000076183:Tripartite Motif-Containing Protein 28; D044767:Ubiquitin-Protein Ligases; D000099207:SS-A Antigen; C094314:TRIM22 protein, human; C117731:TRIM16 protein, human; C101116:TRIM28 protein, human; C477346:TRIM5 protein, human