title: Pharmacokinetics and protein binding of linezolid in cerebrospinal fluid and serum in a case of post-neurosurgical bacterial meningitis.
abstract: We describe a case of bacterial meningitis in a patient administered linezolid (LZD). The ratio of free to total LZD concentrations in cerebrospinal fluid (CSF) was 1 for all measurements, and the LZD concentration in CSF measured at the trough level was almost the same as the free serum concentration.
authors.affiliation: Department of Pharmacy, Sasebo Chuo Hospital, Sasebo, Nagasaki, Japan. yas_tsuji@hakujyujikai.or.jp
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Tsuji
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hiraki
authors.forename: Kana
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Akiko
authors.initials: A
authors.lastname: Mizoguchi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sadoh
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Takemura
authors.forename: Seisaburo
authors.initials: S
authors.lastname: Sakamoto
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Morita
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Kamimura
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Karube
mesh_terms: D000081:Acetamides / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002555:Cerebrospinal Fluid / Q000737:chemistry*; D006801:Humans; D000069349:Linezolid; D008297:Male; D016920:Meningitis, Bacterial / Q000188:drug therapy*; D008875:Middle Aged; D023303:Oxazolidinones / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011183:Postoperative Complications; D011485:Protein Binding; D011506:Proteins / Q000378:metabolism*; D044967:Serum / Q000737:chemistry*
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D011506:Proteins; D000069349:Linezolid