title: Reduced insulin-like growth factor-I serum levels in formerly obese women subjected to laparoscopic-adjustable gastric banding or diet-induced long-term caloric restriction.
abstract: Life-span extension in laboratory rodents induced by long-term caloric restriction correlates with decreased serum insulin-like growth factor-I (IGF-I) levels. Reduced activity of the growth hormone/IGF-I signaling system slows aging and increases longevity in mutant mouse models. In the present study, we show that long-term caloric restriction achieved by two different interventions for 4 years, either laparoscopic-adjustable gastric banding or reducing diet, leads to reduced IGF-I serum levels in formerly obese women relative to normal-weight women eating ad libitum. Moreover, we present evidence that the long-term caloric restriction interventions reduce fasting growth hormone serum levels. The present study indicates that the activity of the growth hormone/IGF-I axis is reduced in long-term calorically restricted formerly obese humans. Furthermore, our findings suggest that the duration and severity of the caloric restriction intervention are important for the outcome on the growth hormone/IGF-I axis in humans.
authors.affiliation: Department of Cell Metabolism and Differentiation Research, Institute for Biomedical Aging Research of the Austrian Academy of Sciences, Rennweg 10, 6020 Innsbruck, Austria.
authors.forename: Maria C
authors.initials: MC
authors.lastname: Mitterberger
authors.forename: Monika
authors.initials: M
authors.lastname: Mattesich
authors.forename: Elise
authors.initials: E
authors.lastname: Klaver
authors.forename: Hildegunde
authors.initials: H
authors.lastname: Piza-Katzer
authors.forename: Werner
authors.initials: W
authors.lastname: Zwerschke
mesh_terms: D031204:Caloric Restriction; D003430:Cross-Sectional Studies; D005260:Female; D015391:Gastroplasty; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D010535:Laparoscopy; D009767:Obesity, Morbid / Q000097:blood* / Q000601:surgery; D011184:Postoperative Period; D013997:Time Factors
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I