title: [Expression of podoplanin in ovarian clear cell carcinoma].
abstract: BACKGROUND
  Podoplanin is a transmembrane glycoprotein expressed in endothelial lymphatic cells. It was proven to be a predictive marker in a variety of cancers e.g. mesothelioma and head and neck squamous-cell carcinoma. Ovarian clear cell carcinoma (OCCC) is a rare and unique histopathologic subtype of epithelial ovarian cancer (EOC). The molecular basis of that phenomenon remains unknown.
  
  
  OBJECTIVE
  The aim of our study was to assess podoplanin expression on the protein level in OCCC.
  
  
  METHODS
  Immunohistochemistry was performed on paraffin-embedded tissues from 19 patients with diagnosed OCCC.
  
  
  RESULTS
  Podoplanin expression was present (moderate or strong) in 52% of OCCC cases (10/19). Nine of eleven (81.2%) postmenopausal and one of eight (12.5%) premenopausal women were podoplanin positive. No differences in podoplanin expression were found in relation to clinical features of the tumor
  
  
  CONCLUSIONS
  The incidence of podoplanin expression is higher in ovarian clear cell adenocarcinoma in postmenopausal patients.
authors.affiliation: 1st Dept of Gynecological Oncology and Gynecology Medical University of Lublin, Poland.
authors.forename: Jozef
authors.initials: J
authors.lastname: Kotarski
authors.forename: Barbara
authors.initials: B
authors.lastname: Marzec-Kotarska
authors.forename: Justyna
authors.initials: J
authors.lastname: Szumiło
authors.forename: Robert
authors.initials: R
authors.lastname: Klepacz
authors.forename: Marek
authors.initials: M
authors.lastname: Cybulski
authors.forename: Sobstyl
authors.initials: S
authors.lastname: Małgorzata
authors.forename: Wiesława
authors.initials: W
authors.lastname: Bednarek
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008562:Membrane Glycoproteins / Q000032:analysis*; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology; D000098853:Podoplanin
chemical_list: D014408:Biomarkers, Tumor; D008562:Membrane Glycoproteins; C117468:PDPN protein, human; D000098853:Podoplanin