title: Potential clinical insights into microRNAs and their target genes in esophageal carcinoma.
abstract: Esophageal carcinoma (EC) are characterized by dysregulation of microRNAs, which play an important roles as a posttranscriptional regulators in protein synthesis, and are involved in cellular processes, such as proliferation, apoptosis, and differentiation. Recently, altered miRNAs expression has been comprehensively studied in EC by high-throughput technology. Increased understanding of miRNAs target genes and their potential regulatory mechanisms have clarified the miRNAs activities and may provide exciting opportunities for cancer diagnosis and miRNA-based genetherapy. Here, we reviewed the most recently discovered miRNA target genes, with particular emphasis on the deciphering of their possible mechanisms and the potential roles in miRNAs-based tumour therapeutics.
authors.affiliation: Department of Surgical Oncology, Affiliated Nanjing First Hospital of Nanjing Medical University and Oncology Center of Nanjing Medical University, Nanjing, Jiangsu Province, China.
authors.forename: Su Q
authors.initials: SQ
authors.lastname: Li
authors.forename: He M
authors.initials: HM
authors.lastname: Wang
authors.forename: Xiu F
authors.initials: XF
authors.lastname: Cao
mesh_terms: D042241:Early Diagnosis; D044127:Epigenesis, Genetic; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*
chemical_list: D035683:MicroRNAs