title: [Aging, age-related diseases, and certain risk factors of cardiovascular diseases in subjects of advanced and senile age].
abstract: The aim of the work was to study sex-specific differences between certain risk factors of cardiovascular diseases and hemodynamic parameters in elderly subjects and their relation to age-specific diseases and genealogic history of longevity. Total cholesterol, triglyceride, glucose, fibrinogen, uric acid, urea, creatinine levels in plasma and arterial pressure (AP) were measured. Hemodynamic parameters were calculated by the formulas for the stroke volume, cardiac output, myocardial contractility, pulse pressure, total peripheral resistance (TPR), endurance factor of cardiac activity, and Kerdo index. Each new decade of life was characterized by peculiar hemodynamic patterns. Pulse AP (PAP) and TPR increased with age and was associated with sex-related metabolic changes. Elderly men presented with hypocholesterolemia and anemia. Total cholesterol, fibrinogen, and glucose levels did not correlate with age. To conclude, elevated PAP, TPR, and left ventricular hypertrophy are risk factors of cardiovascular diseases in old subjects. Combination of several risk factors in young and middle-age subjects reduces prognostic value of the longevity factor in the familial history. Aging is accompanied by the development of gender-related differences in metabolic parameters.
authors.forename: Kh G
authors.initials: KhG
authors.lastname: Alidzhanova
authors.forename: B A
authors.initials: BA
authors.lastname: Kaurov
mesh_terms: D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009017:Morbidity / Q000639:trends; D011379:Prognosis; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology; D055815:Young Adult