title: Intra-aortic balloon pump use does not affect the renal function in patients undergoing off pump coronary artery bypass surgery.
abstract: Renal dysfunction is known to occur during cardiac surgery. A few factors such as perioperative hypotension, use of potential nephrotoxic therapeutic agents, radio opaque contrast media in the recent past, intra-aortic balloon pump (IABP) and cardiopulmonary bypass have been blamed as the contributing factors to the causation of postoperative renal dysfunction in cardiac surgical patients. At times, in patients with renal failure and low cardiac output status, one may face the dilemma if the use of IABP is safe. We undertook this prospective observational study to determine the degree of possible renal injury when IABP is used by measuring serial values of serum creatinine and Cystatin C. Elective patients scheduled for off-pump coronary artery bypass surgery requiring preoperative use of IABP were included in this study. Cystatin C and serum creatinine levels were checked at fixed intervals after institution of IABP. Twenty-two patients were eligible for enrolment to the study. There was no significant change in the values of serum creatinine; from the basal value of 1.10 ± 0.233 to 0.98 ± 0.363 mg /dL (P value >0.05). Cystatin C levels significantly decreased from the basal level of 0.98 ± 0.29 to 0.89 ± 0.23 (P value <0.05). Contrary to the belief, Cystatin C, the early indicator of renal dysfunction decreases suggesting absence of renal injury after the use of IABP. Absence of elevation of cystatin C levels in our study suggests the lack of potential of the IABP to cause renal dysfunction in patients who received elective IABP therapy preoperatively.
authors.affiliation: Department of Anesthesia, Critical Care and Pain Relief, Fortis Hospitals, Bangalore, India.
authors.forename: Geetha
authors.initials: G
authors.lastname: Muniraju
authors.forename: Sourabh
authors.initials: S
authors.lastname: Pandey
authors.forename: Murali
authors.initials: M
authors.lastname: Chakravarthy
authors.forename: Jayaprakash
authors.initials: J
authors.lastname: Krishnamoorthy
authors.forename: Sandeep
authors.initials: S
authors.lastname: Narayan
authors.forename: Vivek
authors.initials: V
authors.lastname: Jawali
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D000368:Aged; D047549:Coronary Artery Bypass, Off-Pump / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D055316:Cystatin C / Q000097:blood; D006801:Humans; D007423:Intra-Aortic Balloon Pumping / Q000009:adverse effects*; D007668:Kidney / Q000503:physiopathology; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D055316:Cystatin C; D003404:Creatinine