title: Evaluation of the choroidal thickness using high-penetration optical coherence tomography with long wavelength in highly myopic normal-tension glaucoma.
abstract: OBJECTIVE
  To evaluate the choroidal thickness by high-penetration optical coherence tomography (OCT) using long wavelength in highly myopic normal-tension glaucoma (NTG).
  
  
  METHODS
  Cross-sectional retrospective study.
  
  
  METHODS
  
  
  
  METHODS
  Institutional.
  
  
  METHODS
  Twelve eyes from 8 patients under 45 years old, diagnosed as NTG without any other ocular diseases, spherical equivalent refractive error between -6 and -12 diopters, and axial length greater than 26.5 mm; and 12 eyes of matched healthy volunteers.
  
  
  METHODS
  Choroid was imaged with prototype high-penetration OCT and its thickness was measured.
  
  
  METHODS
  Choroidal thickness at the fovea and 5 locations: 2 mm superior, temporal, and inferior to the center of the optic nerve head, and 2 mm superior (superotemporal) and 2 mm inferior (inferotemporal) to the temporal location.
  
  
  RESULTS
  Overall, the choroidal thickness in the NTG group was approximately 50% that in controls. Mean choroidal thickness in the NTG group was significantly thinner in the control group at the fovea (166 vs 276 μm, P < .001), superior (172 vs 241 μm, P < 0.05), superotemporal (161 vs 244 μm, P < .01), temporal (110 vs 161 μm, P < .01), and inferotemporal (115 vs 159 μm, P < .05) to the optic nerve head. Stepwise analysis disclosed that the foveal choroidal thickness is the most influential factor on the occurrence of NTG (P < .0001, R(2) = 0.4).
  
  
  CONCLUSIONS
  Choroidal thickness in highly myopic NTG is significantly thinner than in controls, at least in some specific locations. Choroidal thinning is somehow related with highly myopic NTG and may be a useful diagnostic parameter for myopic NTG.
authors.affiliation: Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Usui
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ikuno
authors.forename: Atsuya
authors.initials: A
authors.lastname: Miki
authors.forename: Kenji
authors.initials: K
authors.lastname: Matsushita
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Yasuno
authors.forename: Kohji
authors.initials: K
authors.lastname: Nishida
mesh_terms: D000328:Adult; D001837:Body Weights and Measures; D002829:Choroid / Q000473:pathology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D057066:Low Tension Glaucoma / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male; D047728:Myopia, Degenerative / Q000175:diagnosis* / Q000503:physiopathology; D012372:ROC Curve; D012189:Retrospective Studies; D012307:Risk Factors; D041623:Tomography, Optical Coherence; D014786:Vision Disorders / Q000175:diagnosis / Q000503:physiopathology; D014794:Visual Fields