title: Preparation of imprinted polymers at surface of magnetic nanoparticles for the selective extraction of tadalafil from medicines.
abstract: In this paper, highly selective core-shell molecularly imprinted polymers (MIPs) of tadalafil on the surface of magnetic nanoparticles (MNPs) were prepared. Three widely used functional monomers 2-(trifluoromethyl) acrylic acid (TFMAA), acrylic acid (AA), and methacrylic acid (MAA) were compared theoretically as the candidates for MIP preparation. MIP-coated magnetic nanoparticles (MIP-coated MNPs) showed large adsorption capacity, high recognition ability, and fast binding kinetics for tadalafil. Furthermore, because of the good magnetic properties, MIP-coated MNPs can achieve rapid and efficient separation with an external magnetic field simply. The resulting MIP-coated MNPs were used as dispersive solid-phase extraction (DSPE) materials coupled with HPLC-UV for the selective extraction and detection of tadalafil from medicines (herbal sexual health products). Encouraging results were obtained. The amounts of tadalafil that were detected from the herbal sexual health product was 43.46 nmol g(-1), and the recoveries were in the range of 87.36-90.93% with the RSD < 6.55%.
authors.affiliation: School of Pharmacy, Nanjing Medical University, Nanjing City 210029, P.R. China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Li
authors.forename: Mei-Juan
authors.initials: MJ
authors.lastname: Ding
authors.forename: Shu
authors.initials: S
authors.lastname: Wang
authors.forename: Ruo-Yu
authors.initials: RY
authors.lastname: Wang
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Wu
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Wen
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Yuan
authors.forename: Peng
authors.initials: P
authors.lastname: Dai
authors.forename: Yu-Hui
authors.initials: YH
authors.lastname: Lin
authors.forename: Xue-Min
authors.initials: XM
authors.lastname: Zhou
mesh_terms: D000179:Acrylates / Q000737:chemistry; D000327:Adsorption; D002243:Carbolines / Q000737:chemistry* / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008689:Methacrylates / Q000737:chemistry; D054802:Molecular Imprinting / Q000379:methods*; D011108:Polymers / Q000737:chemistry*; D052616:Solid Phase Extraction / Q000379:methods; D000068581:Tadalafil
chemical_list: C411824:2-(trifluoromethyl)acrylic acid; D000179:Acrylates; D002243:Carbolines; D004365:Drugs, Chinese Herbal; D058185:Magnetite Nanoparticles; D008689:Methacrylates; D011108:Polymers; C008384:methacrylic acid; D000068581:Tadalafil; C036658:acrylic acid