title: [Analysis of correlation between serum somatostatin levels, antioxidant index and metabolic syndrome].
abstract: OBJECTIVE
  To investigate serum somatostatin levels, antioxidant index in metabolic syndrome (MS).
  
  
  METHODS
  Serum somatostatin levels, glucose, lipid level and certain antioxidant indexes were measured in the serum of 39 patients with MS, 60 MS high risk subjects (MSR) and 41 normal controls (NC). The associations of somatostatin with atherosclerotic index (AI), HOMA-IR and malondialdehyde (MDA) were analyzed.
  
  
  RESULTS
  (1) Median somatostatin levels were lower in subjects with MS or MSR than in control subjects. (2) The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) decreased in subjects with MS or MSR compared with NC (P < 0.05). (3) A significant inverse relationships between somatostatin level and AI (r = -0.24, P < 0.01), HOMA-IR (r = -0.23, P < 0.05), and MDA (r = -0.25, P < 0.01) were observed.
  
  
  CONCLUSIONS
  The severity of serum glucose and lipid disorders and oxidative stress was accompanied with decreased somatostatin levels. These results suggest a possible role of decreased somatostatin on MS generation.
authors.affiliation: The Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
authors.forename: Ruili
authors.initials: R
authors.lastname: Yang
authors.forename: Wu
authors.initials: W
authors.lastname: Li
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Shi
authors.forename: Guowei
authors.initials: G
authors.lastname: Le
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology; D013004:Somatostatin / Q000097:blood*; D013482:Superoxide Dismutase / Q000097:blood*
chemical_list: D013004:Somatostatin; D002374:Catalase; D013482:Superoxide Dismutase