title: A few examples of the contribution of animal research in rodents for clinical application of deep brain stimulation.
abstract: In the late 1980s, deep brain stimulation has regained interest for the treatment of neurological disorders. The first spectacular application has been developed for the treatment of Parkinson's disease. This development has been the result of interactions between clinical observations and studies carried out in animal models. Further investigations in animal models have lead to consider not only possible side effects of DBS on nonmotor functions in parkinsonian patients but also DBS as a possible strategy for other diseases, including psychiatric disorders such as obsessive compulsive disorder or addiction.
authors.affiliation: Laboratoire de Neurobiologie de la Cognition (LNC), Université de Provence, Marseille, France. christelle.baunez@univ-provence.fr
authors.forename: Christelle
authors.initials: C
authors.lastname: Baunez
mesh_terms: D032761:Animal Experimentation; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D046690:Deep Brain Stimulation / Q000379:methods*; D006801:Humans; D001523:Mental Disorders / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D023421:Models, Animal; D009422:Nervous System Diseases / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D011930:Reaction Time; D012377:Rodentia; D020531:Subthalamic Nucleus / Q000473:pathology / Q000502:physiology / Q000503:physiopathology