title: [Changes of NO-ergic activity in the salivary glands of rats under conditions of omeprazole-induced hypergastrinemia].
abstract: Under conditions of omeprazole-induced hypergastrinemia the activity of NOS and the concentration of NO2-, the end product of metabolism of nitric oxide were studied in salivary glands of rats. We detected an increase in NOS activity, reaching a maximum (7.61+/-0.39 Mmol [NO2-]/(g*min) at 14th day of the experiment. At 28th day following omeprazole introduction its activity was 5,76+/-0.25 Mmol [NO2-]/(g*min).
authors.forename: A A
authors.initials: AA
authors.lastname: Sukhomlyn
authors.forename: T V
authors.initials: TV
authors.lastname: Berehova
authors.forename: K S
authors.initials: KS
authors.lastname: Neporada
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D005755:Gastrins / Q000097:blood / Q000378:metabolism*; D008297:Male; D009569:Nitric Oxide / Q000096:biosynthesis*; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D009853:Omeprazole / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012469:Salivary Glands / Q000201:enzymology / Q000378:metabolism*; D013997:Time Factors
chemical_list: D005755:Gastrins; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D009853:Omeprazole