title: Multiscale-patient-specific artery and atherogenesis models.
abstract: In this work, we present a platform for the development of multiscale patient-specific artery and atherogenesis models. The platform, called ARTool, integrates technologies of 3-D image reconstruction from various image modalities, blood flow and biological models of mass transfer, plaque characterization, and plaque growth. Patient images are acquired for the development of the 3-D model of the patient specific arteries. Then, blood flow is modeled within the arterial models for the calculation of the wall shear stress distribution (WSS). WSS is combined with other patient-specific parameters for the development of the plaque progression models. Real-time simulation can be performed for same cases in grid environment. The platform is evaluated using both animal and human data.
authors.affiliation: Foundation of Research and Technology Hellas-Biomedical Research Institute, Ioannina, Greece. psiogkas@cc.uoi.gr
authors.forename: P
authors.initials: P
authors.lastname: Siogkas
authors.forename: A
authors.initials: A
authors.lastname: Sakellarios
authors.forename: T P
authors.initials: TP
authors.lastname: Exarchos
authors.forename: L
authors.initials: L
authors.lastname: Athanasiou
authors.forename: E
authors.initials: E
authors.lastname: Karvounis
authors.forename: K
authors.initials: K
authors.lastname: Stefanou
authors.forename: E
authors.initials: E
authors.lastname: Fotiou
authors.forename: D I
authors.initials: DI
authors.lastname: Fotiadis
authors.forename: K K
authors.initials: KK
authors.lastname: Naka
authors.forename: L K
authors.initials: LK
authors.lastname: Michalis
authors.forename: N
authors.initials: N
authors.lastname: Filipovic
authors.forename: O
authors.initials: O
authors.lastname: Parodi
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000473:pathology / Q000503:physiopathology*; D001783:Blood Flow Velocity / Q000502:physiology*; D003198:Computer Simulation; D017023:Coronary Angiography; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008955:Models, Cardiovascular; D058226:Plaque, Atherosclerotic / Q000473:pathology / Q000503:physiopathology*