title: [Oxidative stress in patients with mechanical jaundice of different origin and severity].
abstract: This randomized clinical study included 118 patients with mechanical jaundice (MJ) of different origin and severity. It highlighted the role of free radical-generation processes (FRP) in the development of the disease within 1 day after its onset. Disbalance of FRP affects oxygen and lipid components of oxidative stress and is especially well pronounced in severe cases and in patients with tumours. It becomes increasingly apparent with time from the onset of jaundice and endotoxicosis. FRP disbalance precedes clinical manifestation of jaundice and persists for a long time even after alleviation of its clinical symptoms. Certain signs have a prognostic values. Therapy with reamberin at a daily dose of 400 ml is shown to effectively correct oxidative stress associated with MJ of tumorous and non-tumorous origin regardless of the severity of the disease. Positive effect of antioxidative therapy is accompanied by the improvement of laboratory characteristics, clinical picture, and outcome of the disease.
authors.forename: E V
authors.initials: EV
authors.lastname: Silina
authors.forename: V A
authors.initials: VA
authors.lastname: Stupin
authors.forename: T V
authors.initials: TV
authors.lastname: Gakhramanov
authors.forename: M A
authors.initials: MA
authors.lastname: Khokonov
authors.forename: S B
authors.initials: SB
authors.lastname: Bolevich
authors.forename: N I
authors.initials: NI
authors.lastname: Men'shova
authors.forename: T G
authors.initials: TG
authors.lastname: Sinel'nikova
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D016166:Free Radical Scavengers / Q000378:metabolism*; D006801:Humans; D041781:Jaundice, Obstructive / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D008297:Male; D008536:Meglumine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D012720:Severity of Illness Index; D013386:Succinates / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D016166:Free Radical Scavengers; C549374:Reamberin; D013386:Succinates; D008536:Meglumine