title: SDF1β expression in renal cell carcinoma correlates with grading and infiltration by CD8+ T-cells.
abstract: For several tumor entities, a significant correlation between the chemokine stromal cell-derived factor 1 (SDF1) and its receptor C-X-C chemokine receptor type 4 (CXCR4), metastasis and tumor proliferation, as well as prognosis, has been described. In this study, a series of 105 renal cell carcinoma patients were analyzed in terms of expression of SDF1α and SDF1β and infiltration by CD4+ and CD8+ T-cells and the data correlated with TNM category, grading and survival. While the splice variant SDF1α had no impact on tumor grading, T-cell invasion or overall survival, expression of SDF1β showed a significant correlation with tumor grading and also suggested a correlation with metastasis, as well as CD8+ T-cell invasion. These results indicate a potential T-cell-mediated antitumor response induced by SDF1β up-regulation. Therefore targeting the SDF1β-CXCR4 signaling pathway may be a promising means for new therapeutic strategies in advanced tumor stages.
authors.affiliation: Third Department of Internal Medicine, Johannes Gutenberg University of Mainz, Mainz, Germany.
authors.forename: T C
authors.initials: TC
authors.lastname: Wehler
authors.forename: C
authors.initials: C
authors.lastname: Graf
authors.forename: K
authors.initials: K
authors.lastname: Altherr
authors.forename: T
authors.initials: T
authors.lastname: Zimmermann
authors.forename: W
authors.initials: W
authors.lastname: Brenner
authors.forename: J W
authors.initials: JW
authors.lastname: Thüroff
authors.forename: S
authors.initials: S
authors.lastname: Biesterfeld
authors.forename: I
authors.initials: I
authors.lastname: Gockel
authors.forename: M
authors.initials: M
authors.lastname: Theobald
authors.forename: P R
authors.initials: PR
authors.lastname: Galle
authors.forename: C C
authors.initials: CC
authors.lastname: Schimanski
mesh_terms: D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002292:Carcinoma, Renal Cell / Q000276:immunology / Q000378:metabolism*; D054377:Chemokine CXCL12 / Q000378:metabolism*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000276:immunology / Q000378:metabolism*; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology*; D008297:Male; D008875:Middle Aged
chemical_list: D054377:Chemokine CXCL12