title: Physical (in)activity over 20 y in adulthood: associations with adult lipid levels in the 1958 British birth cohort.
abstract: OBJECTIVE
  To investigate associations between physical (in)activity at different life-stages and lipids in mid-adulthood, examining the role of potential confounding and mediating factors, such as adiposity.
  
  
  METHODS
  Data from the 1958 British birth cohort (n=7824) were examined. Using linear regression, we analysed prospectively reported frequency of activity and TV-viewing (23, 33, 42 and 45 y) in relation to total, LDL-, HDL-cholesterol and triglycerides, at 45 y.
  
  
  RESULTS
  Activity at different ages was associated with HDL-cholesterol and triglycerides at 45 y: e.g. in men, a 1 day/week greater activity frequency at 42 y was associated with 0.006 mmol/L higher HDL-cholesterol and 1.4% lower triglycerides. Most associations attenuated, but were not entirely explained by adjustment for covariates (life-styles and socio-economic factors): e.g. among men, the estimated 2.0% lower triglycerides per 1 day/week greater frequency at 33 y reduced to 1.8% after adjustment. Among women, though not men, activity at both 23 and 45 y contributed cumulatively to HDL-cholesterol. For sedentary behaviour, associations were found for sitting at work: a 1 h/day greater sitting among men was associated with a 0.012 mmol/L lower HDL-cholesterol after adjustment for covariates. Associations were seen for TV-viewing: e.g. in men, a 0.04 mmol/L lower HDL-cholesterol and 5.9% higher triglycerides per hour/day greater TV-viewing at 45 y, attenuated, respectively, to 0.03 mmol/L and 4.6% after adjustment for covariates. Associations attenuated further after adjustment for current BMI. Associations for total and LDL-cholesterol were less consistent.
  
  
  CONCLUSIONS
  Activity and sedentary behaviour at different adult ages were associated with HDL-cholesterol and triglycerides in mid-adulthood. Associations were partly mediated by other life-style factors and by BMI.
authors.affiliation: MRC Centre of Epidemiology for Child Health, Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.
authors.forename: Myung
authors.initials: M
authors.lastname: Ki
authors.forename: Theodora
authors.initials: T
authors.lastname: Pouliou
authors.forename: Leah
authors.initials: L
authors.lastname: Li
authors.forename: Chris
authors.initials: C
authors.lastname: Power
mesh_terms: D000328:Adult; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008019:Life Style; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D009765:Obesity / Q000150:complications; D057185:Sedentary Behavior; D014280:Triglycerides / Q000097:blood; D006113:United Kingdom; D044465:White People
chemical_list: D008076:Cholesterol, HDL; D008055:Lipids; D014280:Triglycerides