title: [Genetic variability of the oxytocine receptor: an in silico study].
abstract: There is an ongoing extensive study on the polymorphisms of the oxytocine receptor (OXTR) gene and their relation to certain psychological traits and psychiatric disorders, however the results are contradictory. One of the sources of inconsistency could originate from the fact that the OXTR gene contains more than 270 SNPs (single nucleotide polymorphisms) without clarified molecular effect.
  
  
  OBJECTIVE
  The aim of this study was an in silico analysis of sequence variations between the human and dog OXTR gene.
  
  
  RESULTS
  Comparative analysis of the human and the dog OXTR amino acid sequence revealed that the most robust difference between the two proteins is a five amino acid containing fragment which is present in the human but absent in the dog receptor. In silico addition of this sequence to the dog receptor resulted in a dramatic change in the conformation of the intracellular region.
  
  
  CONCLUSIONS
  In silico comparative analysis of OXTR gene variants among species and individuals might serve as an important cue for predicting the functional effects of genetic variants.
authors.affiliation: Budapesti Müszaki és Gazdaságtudományi Egyetem, Méréstechnika és Információs Rendszerek Tanszék, Budapest, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Marx
authors.forename: Adám
authors.initials: A
authors.lastname: Arany
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Rónai
authors.forename: Péter
authors.initials: P
authors.lastname: Antal
authors.forename: Mária
authors.initials: M
authors.lastname: Sasvári-Szekely
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004285:Dogs; D014644:Genetic Variation; D006801:Humans; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D018045:Receptors, Oxytocin / Q000235:genetics*
chemical_list: D018045:Receptors, Oxytocin