title: Expression of cyclin A and bone morphogenetic protein receptors and response to induction therapy in patients with acute leukemias.
abstract: Bone morphogenetic proteins (BMPs) are multifunctional cytokines that belong to the transforming growth factor β (TGFβ) family. They participate in the regulation of growth, differentiation and apoptosis in a variety of cell types including hematopoietic lineages. To date, the role of BMPs in carcinogenesis has not been well known. Cyclin A is a cell cycle regulatory protein which plays the role of a parameter of cell proliferation in various types of carcinomas including hematological malignancies. The role of BMPRIA, BMPRIB, BMPRI and cyclin A in the pathogenesis of acute leukemias remains unclear. The aim of this study was to evaluate the expression of BMP receptors and cyclin A on blast cells and their possible relationship with clinical outcome. Seventy patients with acute leukemias (28 female and 42 male) and 10 aged-matched healthy controls were studied. All patients were examined before cytostatic treatment. The expression of BMP receptors and cyclin A was detected by flow cytometry. The results show that higher expression of BMPRIA, BMPRIB, BMPRII and cyclin A is related with a higher complete response (CR) rate, higher overall survival (OS) and lower relapse risk. The expressions of BMPRIA, BMPRIB, BMPRII and cyclin A could be useful as prognostic parameters of the proliferation status of acute leukemia cells, but further studies are needed to assess this phenomenon.
authors.affiliation: Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw, Poland. justynadzietczenia@go2.pl
authors.forename: Justyna
authors.initials: J
authors.lastname: Dzietczenia
authors.forename: Tomasz
authors.initials: T
authors.lastname: Wróbel
authors.forename: Bożena
authors.initials: B
authors.lastname: Jaźwiec
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Mazur
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Butrym
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Kuliczkowski
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D052004:Bone Morphogenetic Protein Receptors / Q000378:metabolism*; D019925:Cyclin A / Q000378:metabolism*; D005260:Female; D006801:Humans; D060828:Induction Chemotherapy; D007938:Leukemia / Q000188:drug therapy* / Q000378:metabolism* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D016019:Survival Analysis; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D019925:Cyclin A; D052004:Bone Morphogenetic Protein Receptors