title: Mutagenicity of diagnostic and therapeutical doses of radiopharmaceutical iodine-131 in Wistar rats.
abstract: Iodine-131 ((131)I) is a radioisotope used for the diagnosis and treatment of thyroidal disorders such as hyperthyroidism and cancer. During its decay, (131)I emits beta particles and gamma rays; its physical half-life is 8 days, and it is accumulated preferentially in the thyroid tissue. This study aimed to evaluate the cytotoxicity and mutagenicity of diagnostic and therapeutic doses of (131)I using bone marrow cells of rats treated in vivo in a test system with a single dose by gavage. Concentrations of 5, 25, 50 and 250 μCi in 1 ml of water were used, and after 24 h, the animals were killed. Also, a concentration of 25 μCi/ml of water was used, and the animals were killed after 5 days. The results showed that no concentration of (131)I was cytotoxic and that all concentrations were mutagenic. As a result, there was no statistically significant difference detected by the χ(2) test in the induction of chromosomal aberrations between the different doses. Thus, the present study demonstrated a significant increase in chromosomal aberration in bone marrow cells exposed to (131)I regardless of the dose or the treatment time.
authors.affiliation: Department of Cell Biology and Genetics, State University of Maringá, Maringá, Paraná, Brazil. lisdusman@hotmail.com
authors.forename: Elisângela
authors.initials: E
authors.lastname: Düsman
authors.forename: Alessandra Paim
authors.initials: AP
authors.lastname: Berti
authors.forename: Rosinete Gonçalves
authors.initials: RG
authors.lastname: Mariucci
authors.forename: Nilson Benedito
authors.initials: NB
authors.lastname: Lopes
authors.forename: Veronica Elisa Pimenta
authors.initials: VE
authors.lastname: Vicentini
mesh_terms: D000818:Animals; D003603:Cytotoxins / Q000009:adverse effects / Q000627:therapeutic use; D004326:Drinking / Q000528:radiation effects; D005260:Female; D007457:Iodine Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D008677:Metaphase / Q000528:radiation effects; D008940:Mitotic Index; D009152:Mutagenicity Tests; D011829:Radiation Dosage; D019275:Radiopharmaceuticals / Q000009:adverse effects* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D003603:Cytotoxins; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals