title: Relationship between -344T/C polymorphism in the aldosterone synthase gene and atrial fibrillation in patients with essential hypertension.
abstract: BACKGROUND
  Aldosterone plays an important role in the pathogenesis of non-familial atrial fibrillation (AF). We tested the hypothesis that the -344T/C polymorphism in the aldosterone synthase gene may be associated with non-familial AF in Chinese patients with hypertension.
  
  
  METHODS
  We performed a 1:1 paired case-control study in 310 cases of hypertension with AF and same number matched controls. The -344T/C polymorphism was determined with polymerase chain reaction-restriction fragment length polymorphism.
  
  
  RESULTS
  The distribution of the CYP11B2 genotypes (TT, TC and CC) was 41.9%, 50.6%, and 7.4% in AF patients, which was not different from controls (48.4%, 44.5%, and 7.1%, χ(2) = 2.675, p = 0.263). The difference between the C allele (32.3% vs. 29.4%) was also not significant between two groups (χ(2) = 1.661, p = 0.197). Logistic regression analysis showed that LAD and LVEDD (both p < 0.001), rather than the C allele of the CYP11B2 gene (p= 0.107) were significant predictors for AF. The LAD of C allele carriers is significantly larger than that of non-C allele carriers (p = 0.009).
  
  
  CONCLUSIONS
  Our results indicate that the -344T/C polymorphism in the aldostrone synthase gene is not associated with AF but it might be associated with atrial remodelling in hypertensives.
authors.affiliation: Department of Cardiology, Yuhuangding Hospital, Yantai, China.
authors.forename: Xiaojian
authors.initials: X
authors.lastname: Sun
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Hou
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Yu
authors.initials: Y
authors.lastname: Shi
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Jing
mesh_terms: D001281:Atrial Fibrillation / Q000150:complications* / Q000000981:diagnostic imaging / Q000201:enzymology / Q000235:genetics*; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000000981:diagnostic imaging / Q000201:enzymology* / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D014463:Ultrasonography
chemical_list: D019405:Cytochrome P-450 CYP11B2