title: Automated radiosynthesis of [18F]PBR111 and [18F]PBR102 using the Tracerlab FXFN and Tracerlab MXFDG module for imaging the peripheral benzodiazepine receptor with PET.
abstract: [(18)F]PBR111 and [(18)F]PBR102 are selective radioligands for imaging of the Peripheral Benzodiazepine Receptor (PBR). We have developed a fully automated method for the radiosynthesis of [(18)F]PBR111 and [(18)F]PBR102 in the Tracerlab FX(FN) (30±2% radiochemical yield non-decay-corrected for both tracers) and Tracerlab MX(FDG) (25±2% radiochemical yield non-decay-corrected for both tracers) from the corresponding p-toluenesulfonyl precursors. For all tracers, radiochemical purity was >99% and specific activity was >150GBq/μmol after less than 60min of preparation time.
authors.affiliation: PET and Nuclear Medicine Department, Royal Prince Alfred Hospital, Missenden road, Camperdown NSW 2050, Sydney, Australia. thomas@nucmed.rpa.cs.nsw.gov.au
authors.forename: Thomas
authors.initials: T
authors.lastname: Bourdier
authors.forename: Tien Q
authors.initials: TQ
authors.lastname: Pham
authors.forename: David
authors.initials: D
authors.lastname: Henderson
authors.forename: Timothy
authors.initials: T
authors.lastname: Jackson
authors.forename: Peter
authors.initials: P
authors.lastname: Lam
authors.forename: Michael
authors.initials: M
authors.lastname: Izard
authors.forename: Andrew
authors.initials: A
authors.lastname: Katsifis
mesh_terms: D003287:Contrast Media / Q000138:chemical synthesis*; D004867:Equipment Design; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D006801:Humans; D007553:Isotope Labeling / Q000295:instrumentation*; D049268:Positron-Emission Tomography / Q000379:methods*; D011485:Protein Binding; D018079:Receptors, GABA / Q000737:chemistry*; D012371:Robotics / Q000295:instrumentation*
chemical_list: D003287:Contrast Media; D005462:Fluorine Radioisotopes; D018079:Receptors, GABA; C499229:TSPO protein, human