title: Intramolecular Cyclization Strategies Toward the Synthesis of Zoanthamine Alkaloids.
abstract: Stabilized 2-amino-1,3-dienes can participate in intramolecular Diels-Alder (IMDA) reactions with pendant dienophiles. We found that these dienes can be readily prepared via standard palladium-mediated coupling reactions and have comparable reactivity to 2-oxodienes. Application of these substrates to the synthesis of tetracyclic model systems representing the ABCE motif of the zoanthamines is presented.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358.
authors.forename: Derek
authors.initials: D
authors.lastname: Fischer
authors.forename: Thong X
authors.initials: TX
authors.lastname: Nguyen
authors.forename: Lynnie
authors.initials: L
authors.lastname: Trzoss
authors.forename: Marianna
authors.initials: M
authors.lastname: Dakanali
authors.forename: Emmanuel A
authors.initials: EA
authors.lastname: Theodorakis