title: Treatment of sydenham chorea with intravenous immunoglobulin.
abstract: Sydenham chorea is a post-streptococcal, autoimmune, neuropsychiatric, movement disorder. There is no effective treatment. In a randomized study, comparison was made of the outcomes of 10 children treated with standard management alone compared to 10 who received additional intravenous immunoglobulin. The outcomes were assessed using a clinical rating scale, brain single-photon emission computed tomography, and the duration of symptomatic treatment. All three outcome measurement tools found improved outcomes in the group that received intravenous immunoglobulin.
authors.affiliation: Rheumatic Fever Clinic, Department of Cardiology, Red Cross Children's Hospital, School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa. buley@iafrica.com
authors.forename: Kathleen
authors.initials: K
authors.lastname: Walker
authors.forename: Anita
authors.initials: A
authors.lastname: Brink
authors.forename: John
authors.initials: J
authors.lastname: Lawrenson
authors.forename: Wendy
authors.initials: W
authors.lastname: Mathiassen
authors.forename: Jo M
authors.initials: JM
authors.lastname: Wilmshurst
mesh_terms: D000293:Adolescent; D001921:Brain / Q000000981:diagnostic imaging; D002648:Child; D002675:Child, Preschool; D002819:Chorea / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008297:Male; D011877:Radionuclide Imaging; D016896:Treatment Outcome
chemical_list: D016756:Immunoglobulins, Intravenous