title: First case of anti-ganglioside GM1-positive Guillain-Barré syndrome due to hepatitis E virus infection.
abstract: A 51-year-old previously healthy woman presented with Guillain-Barré syndrome (GBS) and elevated liver enzymes. Further diagnostic investigations showed the presence of an acute hepatitis E infection associated with anti-ganglioside GM1 antibodies. After treatment with intravenous immunoglobulins, the patient made a rapid recovery. Here, we report the first case of GBS due to acute hepatitis E virus (HEV) infection associated with the presence of anti-ganglioside GM1 antibodies. We also review available literature on the association between acute HEV infection and GBS.
authors.affiliation: Department of Hepato-Gastroenterology, GZA St. Augustinus, Oosterveldlaan 24, 2610, Wilrijk, Belgium. Isabelle.maurissen@telenet.be
authors.forename: I
authors.initials: I
authors.lastname: Maurissen
authors.forename: A
authors.initials: A
authors.lastname: Jeurissen
authors.forename: T
authors.initials: T
authors.lastname: Strauven
authors.forename: D
authors.initials: D
authors.lastname: Sprengers
authors.forename: B
authors.initials: B
authors.lastname: De Schepper
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D005260:Female; D005677:G(M1) Ganglioside / Q000276:immunology; D020275:Guillain-Barre Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology* / Q000821:virology*; D016751:Hepatitis E / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000821:virology; D016752:Hepatitis E virus / Q000302:isolation & purification*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008875:Middle Aged; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016896:Treatment Outcome
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D016756:Immunoglobulins, Intravenous; D005677:G(M1) Ganglioside