title: Attenuated age-related thinning of peripapillary retinal nerve fiber layer in long eyes.
abstract: OBJECTIVE
  To assess the impact of axial length on the age-related peripapillary retinal nerve fiber layer (RNFL) thinning.
  
  
  METHODS
  This cross-sectional observational comparative case series included 172 eyes from 172 healthy Korean subjects. Peripapillary RNFL thickness was measured using an Optic Disc Cube 200 × 200 scan of spectral domain Cirrus HD OCT and the axial length was measured using IOL Master Advanced Technology. In age groups based on decade, the normal ranges of peripapillary RNFL thickness for average, quadrant, and clock-hour sectors were determined with 95% confidence intervals. After dividing the eyes into two groups according to axial length (cut-off, 24.50 mm), the degrees of age-related RNFL thinning were compared.
  
  
  RESULTS
  Among the eyes included in the study, 53 (30.81%) were considered to be long eyes (axial length, 25.04 ± 0.48 µm) and 119 (69.19%) were short-to-normal length eyes (axial length, 23.57 ± 0.60 µm). The decrease in average RNFL thickness with age was less in long eyes (negative slope, -0.12 µm/yr) than in short-to-normal length eyes (negative slope, -0.32 µm/yr) (p < 0.001).
  
  
  CONCLUSIONS
  Age-related thinning of peripapillary RNFL thickness is attenuated in long eyes compared to short-to-normal length eyes.
authors.affiliation: Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, #712 Eonjuro, Gangnam-gu, Seoul, Korea.
authors.forename: Eun-Ji
authors.initials: EJ
authors.lastname: Kim
authors.forename: Samin
authors.initials: S
authors.lastname: Hong
authors.forename: Chan Yun
authors.initials: CY
authors.lastname: Kim
authors.forename: Eun Suk
authors.initials: ES
authors.lastname: Lee
authors.forename: Gong Je
authors.initials: GJ
authors.lastname: Seong
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D005123:Eye / Q000033:anatomy & histology*; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000453:epidemiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012720:Severity of Illness Index; D041623:Tomography, Optical Coherence