title: Epidemiological studies of Beijing strains of Mycobacterium tuberculosis from Taipei and other Asian cities based on MIRU profiles.
abstract: The aim of the present study was to investigate the distribution of the Beijing strains of Mycobacterium tuberculosis (MTB) in Taipei and other Asian cities. A total of 323 MTB isolates were analyzed by spacer oligonucleotide typing (spoligotyping) and mycobacterial interspersed repetitive unit (MIRU) typing. The largest cluster of the TB isolates from Taipei was type MT11 (MIRU type 2233-2517-3533). A comparison of the MIRU type data for the Beijing strains from Taipei and previously published MIRU type data for the Beijing strains from Asian cities with major population of Chinese was analyzed. The six major Beijing MIRU types (MT01, MT02, MT08, MT11, MT21, and MT44) were found to be common in four Asian cities including Taipei, Singapore, Hong Kong, and Wuhan. Results of this study indicate that there is geographical difference in the distribution of different Beijing strains of MTB.
authors.affiliation: Graduate Institute of Medical Science, National Defense Medical Center and Tri-Service General Hospital, Taipei.|Division of Clinical Pathology, Department of Pathology, National Defense Medical Center and Tri-Service General Hospital, Taipei.
authors.forename: Jun-Ren
authors.initials: JR
authors.lastname: Sun
authors.affiliation: Divisions of Clinical Research and Molecular Medicine, National Health Research Institutes, Zhunan.
authors.forename: Horng-Yun
authors.initials: HY
authors.lastname: Dou
authors.affiliation: Division of Clinical Pathology, Department of Pathology, National Defense Medical Center and Tri-Service General Hospital, Taipei.|Division of Microbiology, Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei.
authors.forename: Shih-Yi
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Graduate Institute of Medical Science, National Defense Medical Center and Tri-Service General Hospital, Taipei.|Division of Clinical Pathology, Department of Pathology, National Defense Medical Center and Tri-Service General Hospital, Taipei.
authors.forename: Tzong-Shi
authors.initials: TS
authors.lastname: Chiueh
authors.affiliation: Department of Laboratory Medicine, China Medical University Hospital, Taichung.|Graduate Institute of Clinical Medical Science, China Medical University, Taichung.|Department of laboratory medicine, Linkou Chang-Gung Memorial Hospital, Taoyuan, Taiwan.
authors.forename: Jang-Jih
authors.initials: JJ
authors.lastname: Lu
mesh_terms: D015373:Bacterial Typing Techniques / Q000379:methods*; D004269:DNA, Bacterial / Q000032:analysis / Q000235:genetics; D016021:Epidemiologic Studies; D056426:Genetic Loci; D014644:Genetic Variation; D005838:Genotype; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction / Q000379:methods; D012846:Singapore / Q000453:epidemiology; D013624:Taiwan / Q000453:epidemiology; D014376:Tuberculosis / Q000453:epidemiology* / Q000382:microbiology
chemical_list: D004269:DNA, Bacterial