title: One pot synthesis of cis-bispyrimidodiazepinone derivatives via low-valent titanium reagent (TiCl4/Sm).
abstract: An efficient and convenient method for the preparation of cis-bispyrimidodiazepinone derivatives has been described. A variety of substrates can participate in the process with good yields, making this methodology suitable for library synthesis in drug discovery efforts. The mechanistic course of the reaction suggests the involvement of reduction, coupling which determine the products' configuration and cyclization by one-pot.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P. R. China.
authors.forename: Guolan
authors.initials: G
authors.lastname: Dou
authors.forename: Daqing
authors.initials: D
authors.lastname: Shi
mesh_terms: D001381:Azepines / Q000138:chemical synthesis*; D008958:Models, Molecular; D015394:Molecular Structure; D011744:Pyrimidinones / Q000138:chemical synthesis*; D012493:Samarium / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*
chemical_list: D001381:Azepines; D011744:Pyrimidinones; D012493:Samarium; C025096:titanium tetrachloride; D014025:Titanium