title: Brominated aliphatic hydrocarbons and sterols from the sponge Xestospongia testudinaria with their bioactivities.
abstract: Four brominated aliphatic hydrocarbons (1-4), including a novel brominated ene-tetrahydrofuran named as mutafuran H (1), and five sterols (5-9) were isolated from the South China Sea sponge Xestospongia testudinaria. The structure of 1 was determined on the basis of NMR ((1)H, (13)C NMR, HSQC, HMBC, (1)H-(1)H COSY, and NOESY), MS, and optical rotation analysis. Known compounds were identified by comparison of their NMR data with those reported in the literature. Compounds 1-4, and 6-9 were evaluated for their toxicity against Artemia salina larvae, and anti-acetylcholinesterase activity.
authors.affiliation: Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Zhou
authors.forename: Yanan
authors.initials: Y
authors.lastname: Lu
authors.forename: Xiuping
authors.initials: X
authors.lastname: Lin
authors.forename: Bin
authors.initials: B
authors.lastname: Yang
authors.forename: Xianwen
authors.initials: X
authors.lastname: Yang
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000110:Acetylcholinesterase / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D001156:Artemia / Q000187:drug effects / Q000196:embryology; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D006842:Hydrocarbons, Brominated / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D007814:Larva / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D013261:Sterols / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D047131:Xestospongia / Q000737:chemistry*
chemical_list: D002800:Cholinesterase Inhibitors; D006842:Hydrocarbons, Brominated; D013261:Sterols; D000110:Acetylcholinesterase