title: Diabetes and cancer: Looking at the multiligand/RAGE axis.
abstract: The association between diabetes and hyperglycemia and the associated increased risk of several solid and hematologic malignancies has been the subject of investigation for many years. Although the association is not fully understood, current knowledge clearly indicates that diabetes may influence malignant cell transformation by several mechanisms, including hyperinsulinemia, hyperglycemia and chronic inflammation. In this context, the receptor for advanced glycation end-products (RAGE) has emerged as a focal point in its contribution to malignant transformation and tumor growth. We highlight how RAGE, once activated, as it manifests itself in conditions such as diabetes or hyperglycemia, is able to continuously bring about an inflammatory milieu, thus supporting the contribution of chronic inflammation to the development of malignancies.
authors.affiliation: Armando Rojas, Ileana González, Erik Morales, Ramón Pérez-Castro, Jacqueline Romero, Héctor Figueroa, Biomedical Research Labs., Medicine Faculty, Catholic University of Maule, Talca, POB 617, Chile.
authors.forename: Armando
authors.initials: A
authors.lastname: Rojas
authors.forename: Ileana
authors.initials: I
authors.lastname: González
authors.forename: Erik
authors.initials: E
authors.lastname: Morales
authors.forename: Ramón
authors.initials: R
authors.lastname: Pérez-Castro
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Romero
authors.forename: Héctor
authors.initials: H
authors.lastname: Figueroa