title: Low- and high-tech approaches to control Plasmodium parasite transmission by anopheles mosquitoes.
abstract: Current efforts have proven inadequate to stop the transmission of Plasmodium parasites, and hence the spread of malaria, by Anopheles mosquitoes. Therefore, a novel arsenal of strategies for inhibiting Plasmodium infection of mosquitoes is urgently needed. In this paper, we summarize research on two approaches to malaria control, a low-tech strategy based on parasite inhibition by the mosquito's natural microflora, and a high-tech strategy using genetic modification of mosquitoes that renders them resistant to infection and discuss advantages and disadvantages for both approaches.
authors.affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA.
authors.forename: Chris M
authors.initials: CM
authors.lastname: Cirimotich
authors.forename: April M
authors.initials: AM
authors.lastname: Clayton
authors.forename: George
authors.initials: G
authors.lastname: Dimopoulos