title: Gastrointestinal tract specific gene GDDR inhibits the progression of gastric cancer in a TFF1 dependent manner.
abstract: The novel gene GDDR, also named trefoil factor interactions 1, is abundantly expressed in human gastric epithelial cells but significantly down-regulated in gastric cancer. In this study, we first demonstrated that GDDR was specifically expressed in the gastrointestinal tract epithelium, while suppressed in gastric cancer cells. Forced expression of GDDR suppressed the tumor growth as shown by MTT and xenograft assay. siRNA mediated TFF1 inhibition nearly blocked the growth inhibitory role of GDDR. In summary, our study suggested that gastrointestinal tract specific gene GDDR might inhibit gastric cancer growth in a TFF1 dependent manner.
authors.affiliation: Xijing Hospital of Digestive Diseases, and Department of Biochemistry and Molecular Biology, The State Key Lab of Cancer Biology, The Fourth Military Medical University, Changlexi Road No. 15th, Xi'an, 710032, China.
authors.forename: Guanghui
authors.initials: G
authors.lastname: Chu
authors.forename: Shengbin
authors.initials: S
authors.lastname: Qi
authors.forename: Guodong
authors.initials: G
authors.lastname: Yang
authors.forename: Kefeng
authors.initials: K
authors.lastname: Dou
authors.forename: Jianjun
authors.initials: J
authors.lastname: Du
authors.forename: Zifan
authors.initials: Z
authors.lastname: Lu
mesh_terms: D002352:Carrier Proteins / Q000032:analysis / Q000502:physiology*; D049109:Cell Proliferation; D002470:Cell Survival; D018450:Disease Progression; D004848:Epithelium / Q000737:chemistry / Q000378:metabolism / Q000473:pathology; D041981:Gastrointestinal Tract / Q000737:chemistry* / Q000378:metabolism / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D013274:Stomach Neoplasms / Q000235:genetics / Q000473:pathology*; D014018:Tissue Distribution; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins / Q000502:physiology*; D023041:Xenograft Model Antitumor Assays
chemical_list: D002352:Carrier Proteins; C503073:GKN2 protein, human; C051838:TFF1 protein, human; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins