title: Involvement of activating NK cell receptors and their modulation in pathogen immunity.
abstract: Natural Killer (NK) cells are endowed with cell-structure-sensing receptors providing inhibitory protection from self-destruction (inhibitory NK receptors, iNKRs, including killer inhibitory receptors and other molecules) and rapid triggering potential leading to functional cell activation by Toll-like receptors (TLRs), cytokine receptors, and activating NK cell receptors including natural cytotoxicity receptors (NCRs, i.e., NKp46, NKp46, and NKp44). NCR and NKG2D recognize ligands on infected cells which may be endogenous or may directly bind to some structures derived from invading pathogens. In this paper, we address the known direct or indirect interactions between activating receptors and pathogens and their expression during chronic HIV and HCV infections.
authors.affiliation: Centro di Eccellenza per la Ricerca Biomedica (CEBR), Università di Genova, Genova, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Marras
authors.forename: Federica
authors.initials: F
authors.lastname: Bozzano
authors.forename: Andrea
authors.initials: A
authors.lastname: De Maria
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006678:HIV / Q000276:immunology; D015658:HIV Infections / Q000276:immunology / Q000821:virology; D016174:Hepacivirus / Q000276:immunology; D006526:Hepatitis C / Q000276:immunology / Q000821:virology; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D008251:Macaca; D009169:Mycobacterium tuberculosis / Q000276:immunology; D055607:Receptors, Natural Killer Cell / Q000276:immunology*; D014376:Tuberculosis / Q000276:immunology / Q000821:virology
chemical_list: D055607:Receptors, Natural Killer Cell