title: Nucleocapsid protein VP15 of White spot syndrome virus colocalizes with the nucleolar proteins nucleolin and fibrillarin.
abstract: The core nucleocapsid protein VP15 of White spot syndrome virus (WSSV) was shown to interact with DNA and predicted to be involved in the packaging of the WSSV genome. In the present study, we explored the colocalization of VP15 with several nuclear proteins in insect cells. The results showed that the VP15 completely colocalized with nucleolin and fibrillarin, suggesting that VP15 is a nucleolar localization protein and plays an important role in the life cycle of WSSV in host cells.
authors.affiliation: State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, People's Republic of China.
authors.forename: Yuna
authors.initials: Y
authors.lastname: Xing
authors.forename: Zhengli
authors.initials: Z
authors.lastname: Shi
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000378:metabolism; D019590:Nucleocapsid Proteins / Q000235:genetics / Q000378:metabolism*; D033561:Penaeidae / Q000378:metabolism / Q000821:virology; D010750:Phosphoproteins / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism*; D014771:Virion / Q000378:metabolism; D046848:White spot syndrome virus 1 / Q000235:genetics / Q000378:metabolism*; D000097796:Nucleolin
chemical_list: D002868:Chromosomal Proteins, Non-Histone; D009687:Nuclear Proteins; D019590:Nucleocapsid Proteins; D010750:Phosphoproteins; D016601:RNA-Binding Proteins; D000097796:Nucleolin; C047458:fibrillarin