title: Risk factors for eclampsia: a population-based study in Washington State, 1987-2007.
abstract: OBJECTIVE
  We sought to investigate whether previously identified risk factors are associated with eclampsia in a contemporary, heterogeneous cohort of women.
  
  
  METHODS
  Data were collected from birth certificate and hospital discharge records and used to conduct a population-based case-control study among women giving birth to singletons in Washington State from 1987 through 2007. We used multivariable logistic regression to estimate odds ratios and 95% confidence intervals. Multiple imputation procedures were used to address missing data.
  
  
  RESULTS
  Risk of eclampsia was greater in nulliparous compared to parous women. Being a young mother (< 20 years) or an older mother (≥ 35 years) were each associated with elevated eclampsia risk. Longer birth interval, low socioeconomic status, gestational diabetes, prepregnancy obesity, and weight gain during pregnancy above or below recommended guidelines were positively associated with eclampsia. Multiparity and smoking were inversely associated with eclampsia risk.
  
  
  CONCLUSIONS
  Exposures identified more than a decade ago continue to be associated with eclampsia in contemporary birth cohorts.
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. acoghill@fhcrc.org
authors.forename: Anna E
authors.initials: AE
authors.lastname: Coghill
authors.forename: Susanne
authors.initials: S
authors.lastname: Hansen
authors.forename: Alyson J
authors.initials: AJ
authors.lastname: Littman
mesh_terms: D000328:Adult; D001719:Birth Certificates; D001721:Birth Intervals / Q000706:statistics & numerical data; D016022:Case-Control Studies; D015331:Cohort Studies; D016640:Diabetes, Gestational / Q000453:epidemiology*; D004461:Eclampsia / Q000453:epidemiology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008499:Medical Records / Q000706:statistics & numerical data; D015999:Multivariate Analysis; D009765:Obesity / Q000453:epidemiology*; D010298:Parity; D011247:Pregnancy; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology*; D012959:Socioeconomic Factors; D014861:Washington / Q000453:epidemiology; D015430:Weight Gain; D055815:Young Adult