title: CD40 C/T(-1) and CTLA-4 A/G(49) SNPs are associated with autoimmune thyroid diseases in the Chinese population.
abstract: This study was to investigate whether the common polymorphisms of CD40 and CTLA4 genes confer susceptibility to AITD in the Chinese population. A set of unrelated subjects including 303 GD patients, 208 HT patients, and 215 matched healthy controls were recruited. SNPs were genotyped by the method of PCR-RFLP. (1) As for CD40 C/T(-1) SNP, only a significant difference was found in allele frequencies between GD and control groups (P = 0.033). (2) On the part of CTLA-4 A/G(49) SNP, significant differences were found in genotype and allele frequencies between GD and control groups (P = 7.0 × 10(-5) and P = 0.002, respectively), and similar results were found between HT and control groups (P = 0.015 and P = 0.003, respectively). (3) The logistic regression analysis showed there was no interaction between CD40 and CTLA4 genotypes (P = 0.262). These results indicate that both CTLA-4 A/G(49) and CD40 C/T(-1) SNPs are associated with genetic susceptibility of GD, and CTLA-4 A/G(49) is also associated with HT.
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Medical School of Xi'an Jiaotong University, No. 277 West Yanta Road, Xi'an, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.forename: Qiu
authors.initials: Q
authors.lastname: Qin
authors.forename: Ni
authors.initials: N
authors.lastname: Yan
authors.forename: Yuan-Feng
authors.initials: YF
authors.lastname: Zhu
authors.forename: Cui
authors.initials: C
authors.lastname: Li
authors.forename: Xiang-Ju
authors.initials: XJ
authors.lastname: Yang
authors.forename: Xuan
authors.initials: X
authors.lastname: Wang
authors.forename: Madhu
authors.initials: M
authors.lastname: Pandey
authors.forename: Peng
authors.initials: P
authors.lastname: Hou
authors.forename: Jin-An
authors.initials: JA
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D019013:CD40 Antigens / Q000235:genetics*; D060908:CTLA-4 Antigen / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics; D005838:Genotype; D006111:Graves Disease / Q000208:ethnology / Q000235:genetics*; D050031:Hashimoto Disease / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D055815:Young Adult
chemical_list: D019013:CD40 Antigens; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human