title: [Citrulline extracellular level in the nucleus accumbens during feeding behaviour].
abstract: In Sprague-Dawley rats, by means of in vivo microdialysis combined with HPLC analysis it was shown that a consumption of a novel food did not produce any changes in extracellular levels ofcitrulline (an NO-co-product) in the medial n. accumbens. In contrast, the rejection of the novel food caused a rise of the extracellular citrulline level in this brain area which can be completely prevented by intra-accumbal infusion of 0.5 mM 7-nitroindazple, a neuronal NO-synthase inhibitor. The data obtained reveal for the first time that new food rejection (but not its consumption) is characterized by neuronal NO-synthase activation and, very likely, NO production in the medial nucleus accumbens.
authors.forename: N B
authors.initials: NB
authors.lastname: Saul'skaia
authors.forename: Ia V
authors.initials: IaV
authors.lastname: Belozerov
mesh_terms: D000818:Animals; D002956:Citrulline / Q000032:analysis / Q000378:metabolism*; D005247:Feeding Behavior; D008297:Male; D017551:Microdialysis; D009569:Nitric Oxide / Q000378:metabolism / Q000502:physiology*; D009714:Nucleus Accumbens / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002956:Citrulline; D009569:Nitric Oxide