title: [Application of three compartment model and response surface model to clinical anesthesia using Microsoft Excel].
abstract: With the spread of total intravenous anesthesia, clinical pharmacology has become more important. We report Microsoft Excel file applying three compartment model and response surface model to clinical anesthesia. On the Microsoft Excel sheet, propofol, remifentanil and fentanyl effect-site concentrations are predicted (three compartment model), and probabilities of no response to prodding, shaking, surrogates of painful stimuli and laryngoscopy are calculated using predicted effect-site drug concentration. Time-dependent changes in these calculated values are shown graphically. Recent development in anesthetic drug interaction studies are remarkable, and its application to clinical anesthesia with this Excel file is simple and helpful for clinical anesthesia.
authors.affiliation: Department of Anesthesiology, Kumamoto Regional Medical Center Kumamoto 860-0811.
authors.forename: Eiji
authors.initials: E
authors.lastname: Abe
authors.forename: Mari
authors.initials: M
authors.lastname: Abe
mesh_terms: D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous / Q000493:pharmacokinetics; D004347:Drug Interactions; D005283:Fentanyl / Q000493:pharmacokinetics; D008954:Models, Biological; D010880:Piperidines / Q000493:pharmacokinetics; D015742:Propofol / Q000493:pharmacokinetics; D000077208:Remifentanil; D012984:Software; D013997:Time Factors
chemical_list: D018686:Anesthetics, Intravenous; D010880:Piperidines; D000077208:Remifentanil; D005283:Fentanyl; D015742:Propofol