title: The impact of metaphylaxis of kidney stone disease in the renal function at long term in active kidney stone formers patients.
abstract: A total of 150 patients were included in the analysis. Through chart review, we estimated glomerular filtration rate in the first visit and, at least, 5 years later. All patients were divided into two groups: (1) metaphylaxis adherents (n = 74) and (2) metaphylaxis non-adherents (n = 76). We followed all patients for at least 5 years. The Scr percentage of patients and GFR <60 mL/min was compared between groups. Variables were compared between groups using t test, χ(2) tests, odds ratios with 95% confidence intervals. There were no differences at baseline between groups. After 5 years of follow-up, GFR was 77.9 mL/min in non-adherent-metaphylaxis group and in the adherent-metaphylaxis group was 87.3 mL/min, with p value of 0.02. After 5 years of follow-up, we had a GFR <60 mL/min in the adherent-metaphylaxis group (4.89 vs. 21.95%) with p value of 0.001 and OR = 5.36; IC-95% = 1.95-14.8. Metaphylaxis of kidney stone disease could prevent chronic kidney disease.
authors.affiliation: Nephrologist of Clinic Stone Lithocentro, Belo Horizonte, Brazil. jmeneses@lithocentro.com.br
authors.forename: Jose A
authors.initials: JA
authors.lastname: Meneses
authors.forename: Fernando M
authors.initials: FM
authors.lastname: Lucas
authors.forename: Fernando C
authors.initials: FC
authors.lastname: Assunção
authors.forename: Junia P P
authors.initials: JP
authors.lastname: Castro
authors.forename: Rogério B
authors.initials: RB
authors.lastname: Monteiro
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007669:Kidney Calculi / Q000378:metabolism / Q000517:prevention & control*; D007674:Kidney Diseases / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance