title: Cell-based therapies for equine joint disease.
abstract: Joint disease is a major cause of wastage in performance horses. Arthritis can be challenging to treat because articular cartilage has little or no capacity for repair, therapeutic options are limited and are largely targeted at ameliorating clinical signs of joint disease. Cell-based therapies have potential to overcome the intrinsic constraints to articular cartilage repair. This article focuses on cell-based therapies for treatment of equine joint disease. Results from experimental model and human clinical studies are presented along with available data from equine studies.
authors.affiliation: Equine Orthopaedic Research Center, Department of Clinical Sciences, College of Veterinary Medicine and Biological Sciences, Colorado State University, 300 West Drake Road, Fort Collins, CO 80523, USA. David.Frisbie@ColoState.EDU
authors.forename: David D
authors.initials: DD
authors.lastname: Frisbie
authors.forename: Matthew C
authors.initials: MC
authors.lastname: Stewart
mesh_terms: D000818:Animals; D016025:Bone Transplantation / Q000662:veterinary*; D017690:Cell Transplantation / Q000662:veterinary*; D019902:Chondrocytes / Q000637:transplantation*; D050723:Fractures, Bone; D006734:Horse Diseases / Q000628:therapy*; D006736:Horses; D007592:Joint Diseases / Q000628:therapy / Q000662:veterinary*; D033581:Stem Cell Transplantation / Q000662:veterinary*; D054457:Tissue Scaffolds