title: NIDA's Clinical Trials Network: an opportunity for HIV research in community substance abuse treatment programs.
abstract: OBJECTIVE
  HIV continues to be a significant problem among substance users and their sexual partners in the United States. The National Drug Abuse Treatment Clinical Trials Network (CTN) offers a national platform for effectiveness trials of HIV interventions in community substance abuse treatment programs. This article presents the HIV activities of the CTN during its first 10 years.
  
  
  RESULTS
  While emphasizing CTN HIV protocols, this article reviews the (1) HIV context for this work; (2) the collaborative process among providers, researchers, and National Institute on Drug Abuse CTN staff, on which CTN HIV work was based; (3) results of CTN HIV protocols and HIV secondary analyses in CTN non-HIV protocols; and (4) implications for future HIV intervention effectiveness research in community substance abuse treatment programs.
  
  
  CONCLUSIONS
  While the feasibility of engaging frontline providers in this research is highlighted, the limitations of small to medium effect sizes and weak adoption and sustainability in everyday practice are also discussed.
authors.affiliation: HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute, NY 10032, USA. st130@columbia.edu
authors.forename: Susan
authors.initials: S
authors.lastname: Tross
authors.forename: Aimee N C
authors.initials: AN
authors.lastname: Campbell
authors.forename: Donald A
authors.initials: DA
authors.lastname: Calsyn
authors.forename: Lisa R
authors.initials: LR
authors.lastname: Metsch
authors.forename: James L
authors.initials: JL
authors.lastname: Sorensen
authors.forename: Steven
authors.initials: S
authors.lastname: Shoptaw
authors.forename: Louise
authors.initials: L
authors.lastname: Haynes
authors.forename: George E
authors.initials: GE
authors.lastname: Woody
authors.forename: Robert M
authors.initials: RM
authors.lastname: Malow
authors.forename: Lawrence S
authors.initials: LS
authors.lastname: Brown
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Feaster
authors.forename: Robert E
authors.initials: RE
authors.lastname: Booth
authors.forename: Raul N
authors.initials: RN
authors.lastname: Mandler
authors.forename: Carmen
authors.initials: C
authors.lastname: Masson
authors.forename: Beverly W
authors.initials: BW
authors.lastname: Holmes
authors.forename: Grant
authors.initials: G
authors.lastname: Colfax
authors.forename: Audrey J
authors.initials: AJ
authors.lastname: Brooks
authors.forename: Denise A
authors.initials: DA
authors.lastname: Hien
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Schackman
authors.forename: P Todd
authors.initials: PT
authors.lastname: Korthuis
authors.forename: Gloria M
authors.initials: GM
authors.lastname: Miele
mesh_terms: D002986:Clinical Trials as Topic / Q000379:methods*; D003153:Community Health Services / Q000379:methods; D003299:Cooperative Behavior; D015658:HIV Infections / Q000453:epidemiology / Q000517:prevention & control*; D006801:Humans; D054577:National Institute on Drug Abuse (U.S.); D012107:Research Design; D019966:Substance-Related Disorders / Q000534:rehabilitation*; D014481:United States / Q000453:epidemiology