title: Detection of the Pseudomonas Quinolone Signal (PQS) by cyclic voltammetry and amperometry using a boron doped diamond electrode.
abstract: 2-Heptyl-3-hydroxy-4-quinolone, known as the Pseudomonas Quinolone Signal, is a key regulator of bacterial cooperative behaviour known as quorum sensing. A simple electrochemical strategy was employed for its sensitive detection using a bare boron-doped diamond electrode by cyclic voltammetry and amperometry. PQS (and potentially other quinolones) was then detected in cultures of P. aeruginosa pqsL(-) mutant strains.
authors.affiliation: Innovative chromatography Group, Irish Separation Science Cluster (ISSC), University College Cork, Ireland.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.forename: Jeremy D
authors.initials: JD
authors.lastname: Glennon
authors.forename: John H T
authors.initials: JH
authors.lastname: Luong
authors.forename: F Jerry
authors.initials: FJ
authors.lastname: Reen
authors.forename: Fergal
authors.initials: F
authors.lastname: O'Gara
authors.forename: Christina
authors.initials: C
authors.lastname: McSweeney
authors.forename: Gerard P
authors.initials: GP
authors.lastname: McGlacken
mesh_terms: D001895:Boron / Q000737:chemistry*; D018130:Diamond / Q000737:chemistry*; D004563:Electrochemistry / Q000379:methods*; D004566:Electrodes; D006863:Hydrogen-Ion Concentration; D011549:Pseudomonas / Q000166:cytology*; D015363:Quinolones / Q000032:analysis* / Q000138:chemical synthesis / Q000737:chemistry; D053038:Quorum Sensing
chemical_list: C407944:2-heptyl-3-hydroxy-4-quinolone; D015363:Quinolones; D018130:Diamond; D001895:Boron