title: Ultrastructure of the H. pylori microbe in individuals having macrocytosis and B12 deficiency.
abstract: The incidence of Helicobacter pylori gastritis is high in India and the number of individuals with vitamin B12 deficiency is also large. An association has been found between these two factors. It is necessary to determine whether H. pylori infection may be a factor in the causation of B12 deficiency and whether it is associated with any morphological changes on ultrastructural examination. A cohort-based study has been performed, which includes 505 young asymptomatic males. These cases have been investigated for presence of H. pylori and macrocytosis. The study confirms an association between H. pylori infection and B12 deficiency. It is recommended that H. pylori infection be looked for in subjects having macrocytosis of unknown etiology.
authors.affiliation: Jaslok Hospital & Research Center, Deshmukh Marg, Mumbai, India. shailakhubchandani@yahoo.co.in
authors.forename: Shaila R
authors.initials: SR
authors.lastname: Khubchandani
authors.forename: Satish
authors.initials: S
authors.lastname: Kulkarni
authors.forename: Suresh
authors.initials: S
authors.lastname: Teckchandani
authors.forename: Arun
authors.initials: A
authors.lastname: Chitale
mesh_terms: D000328:Adult; D015331:Cohort Studies; D004909:Erythrocyte Indices; D004913:Erythrocytes, Abnormal / Q000382:microbiology / Q000648:ultrastructure; D005753:Gastric Mucosa / Q000382:microbiology / Q000648:ultrastructure; D016481:Helicobacter Infections / Q000097:blood / Q000382:microbiology*; D016480:Helicobacter pylori / Q000302:isolation & purification / Q000648:ultrastructure*; D006801:Humans; D008297:Male; D014806:Vitamin B 12 Deficiency / Q000097:blood / Q000382:microbiology*; D055815:Young Adult