title: Direct DNA conjugation to star polymers for controlled reversible assemblies.
abstract: Polymer biomolecule hybrids represent a powerful class of highly customizable nanomaterials. Here, we report star-polymer conjugates with DNA using a "ligandless" Cu(I) promoted azide-alkyne cycloaddition click reaction. The multivalency of the star-polymer architecture allows for the concomitant conjugation of other molecules along with the DNA, and the conjugation method provides control over the DNA orientation. The star-polymer DNA nanoparticles are shown to assemble into higher-order nanoassemblies through hybridization. Further, we show that the DNA strands can be utilized in controlled disassembly of the nanostructures.
authors.affiliation: Department of Chemistry and Center for Nucleic Acids Science and Technology, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States.
authors.forename: Saadyah
authors.initials: S
authors.lastname: Averick
authors.forename: Eduardo
authors.initials: E
authors.lastname: Paredes
authors.forename: Wenwen
authors.initials: W
authors.lastname: Li
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Matyjaszewski
authors.forename: Subha R
authors.initials: SR
authors.lastname: Das
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D057930:Click Chemistry; D003300:Copper / Q000737:chemistry; D003500:Cyclization; D004247:DNA / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: D000480:Alkynes; D001386:Azides; D011108:Polymers; D003300:Copper; D004247:DNA