title: An open-label, multicenter study of the efficacy and safety of an AM/PM treatment regimen with clobetasol propionate spray 0.05% and calcitriol ointment 3 microg/g in the management of plaque psoriasis.
abstract: Psoriasis is a chronic condition with serious quality-of-life ramifications. Dermatologists seek alternative treatments of patients with plaque psoriasis that provide both efficacy and safety while minimizing exposure to high-potency steroids that can have adverse effects following long-term use. We report an open-label, multicenter study designed to evaluate a morning/evening (AM/PM) treatment regimen involving clobetasol propionate spray 0.05% and calcitriol ointment 3 microg/g for moderate plaque psoriasis. Participants applied clobetasol propionate spray 0.05% in the morning and calcitriol ointment 3 microg/g in the evening for up to 4 weeks. Participants were evaluated at baseline, week 2, and week 4. The results of this study indicate that a 4-week regimen of clobetasol propionate spray 0.05% treatment in the morning and calcitriol ointment 3 microg/g in the evening is efficacious and without unexpected safety issues for the management of moderate plaque psoriasis.
authors.affiliation: Baylor Research Institute, Dallas, Texas, USA.
authors.forename: Alan
authors.initials: A
authors.lastname: Menter
authors.forename: Howard
authors.initials: H
authors.lastname: Sofen
authors.forename: Stacy
authors.initials: S
authors.lastname: Smith
authors.forename: Kim
authors.initials: K
authors.lastname: Papp
authors.forename: Steven
authors.initials: S
authors.lastname: Kempers
authors.forename: Charles P
authors.initials: CP
authors.lastname: Hudson
authors.forename: Luz E
authors.initials: LE
authors.lastname: Colón
authors.forename: Lori A
authors.initials: LA
authors.lastname: Johnson
authors.forename: Ronald
authors.initials: R
authors.lastname: Gottschalk
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002117:Calcitriol / Q000008:administration & dosage*; D002990:Clobetasol / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009824:Ointments; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome; D014815:Vitamins / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D009824:Ointments; D014815:Vitamins; D002990:Clobetasol; D002117:Calcitriol