title: Synthesis of indole and biindolyl triflones: trifluoromethanesulfonylation of indoles with Tf2O/TTBP (2,4,6-tri-tert-butylpyridine) system.
abstract: A convenient synthesis of indole triflones is reported. N-Alkyl, aryl and N-H indole triflones were obtained in 82-96% yields by the Tf(2)O/TTBP System. Biindolyl triflones were accessed in 51-81% yields for the first time by simple treatment of the resulting indole triflones with a base and without any use of organometallic chemistry. An environmentally friendly solvent, Solkane 365/227, can be substituted for this process without any loss of efficiency.
authors.affiliation: Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Nagoya, 466-8555, Japan.
authors.forename: Xiu-Hua
authors.initials: XH
authors.lastname: Xu
authors.forename: Guo-Kai
authors.initials: GK
authors.lastname: Liu
authors.forename: Ayaka
authors.initials: A
authors.lastname: Azuma
authors.forename: Etsuko
authors.initials: E
authors.lastname: Tokunaga
authors.forename: Norio
authors.initials: N
authors.lastname: Shibata
mesh_terms: D005663:Furans / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*; D013237:Stereoisomerism; D013449:Sulfonamides / Q000737:chemistry*; D013450:Sulfones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C568021:2,4,6-tri-tert-butylpyridine; D005663:Furans; D007211:Indoles; D011725:Pyridines; D013449:Sulfonamides; D013450:Sulfones; C030374:indole; C474725:triflic anhydride