title: [Study on sub-chronic toxicity of powered milk containing transgenic human alpha-lactalbumin].
abstract: OBJECTIVE
  To investigate the potential toxic or adverse effect of transgenic human alpha-lactalbumin powered milk on rats.
  
  
  METHODS
  Weanling Wistar rats were randomly divided into seven groups according the weight: three transgenic milk powder (T) groups, three non-transgenic milk powder (N) groups and the control (C) group. The diets of T groups contain 15%, 30% and 60% transgenic human alpha-lactalbumin milk powder. The diets of N groups contain 15%, 30% and 60% non-transgenic human alpha-lactalbumin milk powder for 90 days. The diet of C group contains only basic feed. Haematological and biochemical parameters was measured during the study (at 45th and 90th of the experiment). At the end of the 90th day, organ tissues analysis was performed.
  
  
  RESULTS
  There were no transgenic human alpha-lactalbumin related adverse effects on the body weight, food intake, food consumption, hematology,serum biochemistry, as well as histopathology.
  
  
  CONCLUSIONS
  There were no signs of toxic and adverse effects for transgenic human alpha-lactalbumin powdered milk on rats.
authors.affiliation: Institute of Nutrition and Food Safety, China CDC, Beijing 100021, China. yuanyuan2131@yahoo.com.cn
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhi
authors.forename: Haibo
authors.initials: H
authors.lastname: Liu
authors.forename: Guiying
authors.initials: G
authors.lastname: Geng
authors.forename: Huiling
authors.initials: H
authors.lastname: Wang
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
authors.forename: Xiaolian
authors.initials: X
authors.lastname: Feng
authors.forename: Peng
authors.initials: P
authors.lastname: Gao
authors.forename: Qiang
authors.initials: Q
authors.lastname: Yu
authors.forename: Yongquan
authors.initials: Y
authors.lastname: Feng
authors.forename: Haibin
authors.initials: H
authors.lastname: Xu
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D002417:Cattle / Q000235:genetics*; D003611:Dairy Products / Q000032:analysis / Q000633:toxicity*; D005260:Female; D030841:Food, Genetically Modified / Q000633:toxicity*; D006801:Humans; D007768:Lactalbumin / Q000235:genetics*; D008297:Male; D008892:Milk / Q000737:chemistry / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D018675:Toxicity Tests
chemical_list: D007768:Lactalbumin