title: [Interaction of plasma selenium levels and D12S304 gene site in the pathogenesis of Kashin-Beck disease analyzed by multifactor dimensionality reduction software].
abstract: OBJECTIVE
  To explore the interaction of plasma selenium levels and D12S304 gene site in the pathogenesis of Kashin-Beck disease (KBD).
  
  
  METHODS
  Case-control design was taken to compare the difference of plasma selenium levels and genotype of D12S304 between KBD patients and non-patients, and the interactions were analyzed by MDR software.
  
  
  RESULTS
  Plasma selenium levels was lower in the case group than in the control group, while the D12S304 gene site was not different between the two groups, and no interaction between plasma selenium and genotype was observed.
  
  
  CONCLUSIONS
  There was no interaction between plasma selenium and genotype at D12S304. Enlarging sample size or selecting another gene site might be needed in exploring the gene-environment interactions in the pathogenesis of KBD.
authors.affiliation: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China. pingzhg@zzu.edu.cn
authors.forename: Zhiguang
authors.initials: Z
authors.lastname: Ping
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Xiong
authors.initials: X
authors.lastname: Guo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002648:Child; D002681:China; D005260:Female; D059647:Gene-Environment Interaction; D005838:Genotype; D006801:Humans; D057767:Kashin-Beck Disease / Q000097:blood / Q000209:etiology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D058011:Multifactor Dimensionality Reduction; D012643:Selenium / Q000097:blood* / Q000172:deficiency; D012984:Software; D055815:Young Adult
chemical_list: D012643:Selenium