title: Invited commentary.
authors.forename: Steven D
authors.initials: SD
authors.lastname: Wexner
authors.forename: Marylise
authors.initials: M
authors.lastname: Boutros
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D018426:SEER Program; D012812:Sigmoidoscopy; D014481:United States / Q000453:epidemiology