title: Ultrasound-promoted intramolecular direct arylation in a capillary flow microreactor.
abstract: An intramolecular direct arylation of various aryl bromides was performed using ultrasonic irradiation and a continuous flow capillary microreactor. The present procedure provided a higher functional group tolerance, ligand-free, milder reaction conditions and a shorter reaction time for the direct arylation compared with the conventional methods. The ultrasonic irritation not only greatly promoted the conversion and selectivity of the direct arylation, but also solved the clogging problem of the microreactor for solid-forming reaction and made the reaction run smoothly.
authors.affiliation: State Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Mei
authors.initials: M
authors.lastname: Geng
authors.forename: Peng
authors.initials: P
authors.lastname: Teng
authors.forename: Dan
authors.initials: D
authors.lastname: Zhao
authors.forename: Xi
authors.initials: X
authors.lastname: Lu
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Li
mesh_terms: D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D055616:Microtechnology / Q000295:instrumentation / Q000379:methods*; D012997:Solvents / Q000737:chemistry; D013594:Syringes; D014465:Ultrasonics
chemical_list: D006841:Hydrocarbons, Aromatic; D012997:Solvents