title: Clinical and antimicrobial evaluation of a mouthwash and toothpaste for xerostomia: a randomized, double-blind, crossover study.
abstract: OBJECTIVE
  Specific toothpaste and mouthwash for xerostomia based on triclosan, fluoride, and mineral salts were studied in order to evaluate their efficacy in improving the quality of life as well as their in vitro antimicrobial action.
  
  
  METHODS
  30 patients with dry mouth and hyposalivation confirmed by sialometry were included in a randomized, double-blind, crossover study, during two weeks for each experimental phase. Dryness and oral comfort, difficulty in speaking, chewing, swallowing and using dental prostheses, as well as taste and sleep disorders were evaluated. Values of minimal biocidal and minimal inhibitory concentrations of both products against microorganisms that often cause oral disorders in these patients were determined and compared.
  
  
  RESULTS
  The use of the mouthwash and toothpaste studied improved the dry mouth symptoms, whilst no significant differences when compared with the salivary enzyme substitutes were observed. The test products showed, in general, a higher biocidal and inhibitory action than the control products, with particularly noteworthy action against cariogenic bacteria.
  
  
  CONCLUSIONS
  The use of a toothpaste and mouthwash based on triclosan, fluoride, gingival revitalizers and mineral salts, improves the quality of life of patients suffering xerostomia.
authors.affiliation: University Dental Clinic, University of Murcia, Murcia, Spain. majornet@um.es
authors.forename: M P
authors.initials: MP
authors.lastname: López-Jornet
authors.forename: G
authors.initials: G
authors.lastname: García-Teresa
authors.forename: M
authors.initials: M
authors.lastname: Viñas
authors.forename: T
authors.initials: T
authors.lastname: Vinuesa
mesh_terms: D000368:Aged; D000891:Anti-Infective Agents, Local / Q000494:pharmacology / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002327:Cariostatic Agents / Q000494:pharmacology / Q000627:therapeutic use; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D005459:Fluorides / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007778:Lactobacillus / Q000187:drug effects; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009067:Mouthwashes / Q000737:chemistry / Q000627:therapeutic use*; D011788:Quality of Life; D013291:Streptococcus / Q000187:drug effects; D011795:Surveys and Questionnaires; D014100:Toothpastes / Q000737:chemistry / Q000627:therapeutic use*; D014260:Triclosan / Q000494:pharmacology / Q000627:therapeutic use; D014987:Xerostomia / Q000188:drug therapy* / Q000523:psychology*
chemical_list: D000891:Anti-Infective Agents, Local; D002327:Cariostatic Agents; D009067:Mouthwashes; D014100:Toothpastes; D014260:Triclosan; D005459:Fluorides