title: Benefits of a new pediatric triple-chamber bag for parenteral nutrition in preterm infants.
abstract: OBJECTIVE
  The aim of this study was to evaluate the efficacy, safety, flexibility, and ease of handling and use of the Ped3CB-A 300  mL, the first ready-to-use multichamber parenteral nutrition (PN) system, with optional lipid bag activation, specially designed for administration to preterm infants.
  
  
  METHODS
  In this prospective, open-label, multicenter, noncomparative, phase III clinical trial, preterm infants were treated with Ped3CB-A for 5 to 10 consecutive days.
  
  
  RESULTS
  A total of 113 preterm infants were enrolled in the study and 97 (birth weight 1382 ± 520 g; gestational age 31.2 ± 2.5 weeks; postnatal age administration 5.6 ± 6.1 days) were included in the per protocol analysis accounting for 854 perfusion days. Double-chamber bag activation was used for 32 perfusion days. Macronutrient, electrolyte, and mineral supplements were primarily administered through a Y-line or directly in the activated bag. In all, 199 additions (mainly sodium, 95%) were made to the Ped3CB-A bags on 197 infusion days (23.1%) in 43 infants (44.3%). More than 1 of these nutrients was added to the bag on only 1 perfusion day. Mean and maximum parenteral nutrient intakes were 2.8 ± 0.7 and 3.6 ± 0.8  g amino acids per kilogram per day, and 80 ± 20 and 104 ± 22  kcal · kg(-1) · day(-1). Mean weight gain represented 10.0, 21.5, and 22. 6 g · kg(-1) · day(-1) according to age at inclusion (0-3, 4-7, or >7 days of life). A visual analog scale was completed and produced positive results. No adverse events were attributable to the design of the Ped3CB-A system.
  
  
  CONCLUSIONS
  Ped3CB-A provides easy-to-use, well-balanced, and safe nutritional support. Nutritional intakes and weight gain were within the recent PN recommendations in preterm infants.
authors.affiliation: Department of Paediatrics, Neonatal Unit, University of Liege, Belgium. J.Rigo@ulg.ac.be
authors.forename: Jacques
authors.initials: J
authors.lastname: Rigo
authors.forename: Monica L
authors.initials: ML
authors.lastname: Marlowe
authors.forename: Denis
authors.initials: D
authors.lastname: Bonnot
authors.forename: Thibault
authors.initials: T
authors.lastname: Senterre
authors.forename: Alexandre
authors.initials: A
authors.lastname: Lapillonne
authors.forename: Elsa
authors.initials: E
authors.lastname: Kermorvant-Duchemin
authors.forename: Jean Michel
authors.initials: JM
authors.lastname: Hascoet
authors.forename: Roxane
authors.initials: R
authors.lastname: Desandes
authors.forename: Geneviève
authors.initials: G
authors.lastname: Malfilâtre
authors.forename: Patrick
authors.initials: P
authors.lastname: Pladys
authors.forename: Alain
authors.initials: A
authors.lastname: Beuchée
authors.forename: Virginie
authors.initials: V
authors.lastname: Colomb
mesh_terms: D002149:Energy Intake; D005260:Female; D006801:Humans; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D009751:Nutritional Requirements; D057947:Parenteral Nutrition Solutions / Q000008:administration & dosage* / Q000737:chemistry; D010289:Parenteral Nutrition, Total / Q000295:instrumentation* / Q000379:methods; D011446:Prospective Studies; D015430:Weight Gain
chemical_list: D057947:Parenteral Nutrition Solutions