title: [Genome damage and reactive oxygen species production in the progenies of irradiated CHO-K1 cells].
abstract: A series of experiments to study the delayed effects of gamma-radiation exposure in different generations of the progenies of the Chinese hamster ovary CHO-K1 irradiated cells has been conducted. It has been shown that in the progenies of the cells irradiated with a dose of 1 Gy, the following effects are observed: in the 9-27 cell generations - increase in the genome damage, intracellular production of reactive oxygen species, apoptotic cells percentage and cell sensitivity to additional exposure (irradiation at a dose of 10 Gy); in the 30-42 cell generations - decrease of the studied parameters up to control values and increased resistance to additional exposure. It is assumed that the decrease of the studied parameters up to the control values in the 30-42 postirradiation generations of cells is caused by elimination of damaged cells or transition of genomic instability into a hidden (latent) condition.
authors.forename: A N
authors.initials: AN
authors.lastname: Osipov
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Lizunova
authors.forename: D V
authors.initials: DV
authors.lastname: Gur'ev
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Vorob'eva
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000528:radiation effects*; D016466:CHO Cells; D018929:Cell Culture Techniques; D020552:Comet Assay; D006224:Cricetinae; D003412:Cricetulus; D053903:DNA Breaks, Double-Stranded / Q000528:radiation effects*; D053938:DNA Fragmentation / Q000528:radiation effects*; D005720:Gamma Rays; D042822:Genomic Instability / Q000528:radiation effects*; D017382:Reactive Oxygen Species / Q000378:metabolism*
chemical_list: D017382:Reactive Oxygen Species