title: Human cystic echinococcosis in South Africa.
abstract: Cystic echinococcosis is recognised as causing considerable morbidity and even mortality in South Africa, but the epidemiology of the disease is to date unknown. From current evidence there are also concerns that co-infections with HIV and tuberculosis (TB) considerably increase CE-associated morbidity. The aim of this analysis was to characterise clinical features and disease burden of CE in South Africa in preparation for a prospective study. Retrospective case note analysis of patients presenting to two large academic hospitals in Johannesburg, South Africa, for clinical and demographic data was performed. In addition, data of the National Health Laboratory Service were accessed for requested serological and microscopic investigations for CE and the numbers of positive results evaluated. According to a recently published definition, 14 cases of confirmed CE and 9 cases of probable CE were identified at both hospitals. When accessing the national database it became apparent that even with the most conservative estimate at least 137 patients per year present with CE in South Africa. However, numbers are likely to be much higher for a variety of reasons. Further prospective analysis is necessary to shed more light on the epidemiology, clinical presentation and risk factors for CE, which is currently underway.
authors.affiliation: Comprehensive Infectious Diseases Center, University Hospitals, Albert-Einstein-Allee 23, Ulm, Germany.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Wahlers
authors.forename: Colin N
authors.initials: CN
authors.lastname: Menezes
authors.forename: Michelle
authors.initials: M
authors.lastname: Wong
authors.forename: Benjamin
authors.initials: B
authors.lastname: Mogoye
authors.forename: John
authors.initials: J
authors.lastname: Frean
authors.forename: Thomas
authors.initials: T
authors.lastname: Romig
authors.forename: Peter
authors.initials: P
authors.lastname: Kern
authors.forename: Martin P
authors.initials: MP
authors.lastname: Grobusch
mesh_terms: D000328:Adult; D060085:Coinfection / Q000453:epidemiology; D004443:Echinococcosis / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D006761:Hospitals; D006801:Humans; D015994:Incidence; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D013019:South Africa / Q000453:epidemiology