title: The effect of oral management on the severity of oral mucositis during hematopoietic SCT.
abstract: Oral mucositis (OM) is a frequent adverse effect of allogenic or autologous hematopoietic SCT. It results from direct toxic injury to the mucosal epithelial cells by the immunosuppressive regimen. Here, we compared the incidence and severity of OM between a group of 24 patients who received proper oral management during hematopoietic SCT and a group of 24 who did not. The oral management group received pre-hematopoietic SCT instruction on oral care and an oral examination in the clean room. Differences in the incidence and severity of OM between the two groups were examined statistically. OM was observed in 14 (58.3%) patients in the oral management group and 22 (91.6%) in the control group. The median of the OM score was 1 for the oral management group (range 0 to 3) and 2 for the control group (range 0 to 3). There was a significant difference in the OM score (P<0.05) and in the incidence of OM between the two groups (P<0.01). This study shows that oral management may decrease the occurrence of OM. Our results also suggest that it is important to include an oral management provider on the hematopoietic SCT team.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Clinical Sciences, Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Japan. y-kenji@md.tsukuba.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Yamagata
authors.forename: C
authors.initials: C
authors.lastname: Arai
authors.forename: H
authors.initials: H
authors.lastname: Sasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: K
authors.initials: K
authors.lastname: Onizawa
authors.forename: T
authors.initials: T
authors.lastname: Yanagawa
authors.forename: N
authors.initials: N
authors.lastname: Ishibashi
authors.forename: R
authors.initials: R
authors.lastname: Karube
authors.forename: K
authors.initials: K
authors.lastname: Shinozuka
authors.forename: Y
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: S
authors.initials: S
authors.lastname: Chiba
authors.forename: H
authors.initials: H
authors.lastname: Bukawa
mesh_terms: D000328:Adult; D000368:Aged; D003729:Dental Care; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013280:Stomatitis / Q000209:etiology* / Q000517:prevention & control