title: Diversity-oriented synthesis of 13- to 18-membered macrolactams via ring-closing metathesis.
abstract: An efficient build/couple/pair approach to diversity-oriented synthesis was employed to access several structurally complex macrolactams. In this paper, we describe the successful evaluation of ring-closing metathesis toward the systematic generation of skeletal diversity. By appropriately varying the nature and chain length of the alkenol fragment, a diverse collection of 13- to 18-membered macrolactams were obtained.
authors.affiliation: Chemical Biology Platform, Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, United States.
authors.forename: Sivaraman
authors.initials: S
authors.lastname: Dandapani
authors.forename: Jason T
authors.initials: JT
authors.lastname: Lowe
authors.forename: Eamon
authors.initials: E
authors.lastname: Comer
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Marcaurelle
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D047029:Lactams, Macrocyclic / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D047029:Lactams, Macrocyclic; C116609:3-hydroxybutanal