title: Minocycline-EDTA lock solution prevents catheter-related bacteremia in hemodialysis.
abstract: There is growing concern about the development of antibacterial resistance with the use of antibiotics in catheter lock solutions. The use of an antibiotic that is not usually used to treat other serious infections may be an alternative that may reduce the clinical impact should resistance develop. We conducted a randomized controlled trial to compare a solution of minocycline and EDTA with the conventional unfractionated heparin for the prevention of catheter-related bacteremia in hemodialysis patients during a period of 90 d. The study included 204 incident catheters (27.8% tunneled); 14 catheters were excluded because of early dysfunction and 3 because of protocol violations. We observed catheter-related bacteremia in 19 patients in the heparin group (4.3 per 1000 catheter-days) and in 5 patients in the minocycline-EDTA group (1.1 per 1000 catheter-days; P = 0.005). We did not detect a significant difference in the rate of catheter removal for dysfunction. Catheter-related bacteremia-free survival was significantly higher in the minocycline-EDTA group than in the heparin group (P = 0.005). In conclusion, a minocycline-EDTA catheter lock solution is effective in the prevention of catheter-related bacteremia in hemodialysis patients.
authors.affiliation: Center for Health and Biological Sciences, Pontifícia Universidade Católica do Paraná, Curitiba-PR, Brazil. rodrigopcampos@uol.com.br
authors.forename: Rodrigo Peixoto
authors.initials: RP
authors.lastname: Campos
authors.forename: Marcelo Mazza
authors.initials: MM
authors.lastname: do Nascimento
authors.forename: Domingos Candiota
authors.initials: DC
authors.lastname: Chula
authors.forename: Miguel Carlos
authors.initials: MC
authors.lastname: Riella
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000925:Anticoagulants / Q000008:administration & dosage; D016470:Bacteremia / Q000209:etiology / Q000517:prevention & control*; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D002408:Catheters, Indwelling / Q000009:adverse effects* / Q000382:microbiology; D004492:Edetic Acid / Q000008:administration & dosage; D005260:Female; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000008:administration & dosage*; D006435:Renal Dialysis / Q000295:instrumentation; D016019:Survival Analysis
chemical_list: D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D006493:Heparin; D004492:Edetic Acid; D008911:Minocycline