title: Association of angiotensin II type 1-receptor gene polymorphisms with the risk of developing hypertension in Mexican individuals.
abstract: BACKGROUND
  Hypertension is a complex disease in which a significant interaction between genetic and environmental factors takes place. The renin-angiotensin system plays an important role regulating blood pressure to maintain homeostasis and vascular tone. In the present work, the role of angiotensin II type 1-receptor (AGTR1) gene polymorphisms as susceptibility markers for hypertension was evaluated.
  
  
  METHODS
  Five polymorphisms in the AGTR1 gene were genotyped by 5' exonuclease TaqMan genotyping assays in 239 hypertensive and 371 non-hypertensive individuals.
  
  
  RESULTS
  A similar distribution of rs275651, rs275652, rs275653, and rs5183 polymorphisms was observed in both studied groups. Different distribution of rs5182 genotypes was observed between the studied groups (p = 0.016). According to the co-dominant model, individuals with rs5182 CC genotype have a 1.83-fold increased risk of developing hypertension (p = 0.009). Polymorphisms were distributed in two blocks: block 1 included the rs275651, rs275652, and rs275653 polymorphisms, whereas block 2 included the rs5183 and rs5182 polymorphisms. Individuals with hypertension showed increased frequency of 'CA' haplotype of block 2 when compared to non-hypertensive individuals (p = 0.015, odds ratio = 1.33).
  
  
  CONCLUSIONS
  The results suggest that the rs5182 gene polymorphism could be involved in the risk of developing hypertension in Mexican individuals.
authors.affiliation: Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Nancy
authors.initials: N
authors.lastname: Martínez-Rodríguez
authors.forename: Carlos
authors.initials: C
authors.lastname: Posadas-Romero
authors.forename: Guillermo
authors.initials: G
authors.lastname: Cardoso
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Pérez-Rodríguez
authors.forename: Nonanzit
authors.initials: N
authors.lastname: Pérez-Hernández
authors.forename: Maite
authors.initials: M
authors.lastname: Vallejo
authors.forename: Gilberto
authors.initials: G
authors.lastname: Vargas-Alarcón
mesh_terms: D000483:Alleles; D001794:Blood Pressure / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology; D040582:Inheritance Patterns / Q000235:genetics; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008800:Mexico; D008875:Middle Aged; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics*; D012307:Risk Factors
chemical_list: C544065:AGTR1 protein, human; D044140:Receptor, Angiotensin, Type 1