title: Association between muscle strength and metabolic syndrome in older Korean men and women: the Korean Longitudinal Study on Health and Aging.
abstract: The objective of the study was to investigate the association between metabolic syndrome (MS) and muscle strength in community-dwelling older men and women in Korea. Korean men and women 65 years and older living in a single, typical South Korean city (n = 647) were enrolled in the Korean Longitudinal Study on Health and Aging study. The diagnosis of MS was evaluated according to the definition of the National Cholesterol Education Program Adult Treatment Panel III. Isokinetic muscle strength of the knee extensors, as determined by peak torque per body weight (newton meter per kilogram) and hand-grip strength per body weight (newton per kilogram), was measured. Participants without MS had greater leg muscle strength and grip strength per weight. The effect of MS on muscle strength was more prominent in men than in women in our study population. Only men showed a significant interaction between MS and age for muscle strength (P = .014), and the effect was greater in men aged 65 to 74 years compared with those older than 75 years (119.2 ± 31.2 vs 134.5 ± 24.3 N m/kg). Participants with MS had weaker knee extensor strength after controlling the covariates (β = -90.80, P = .003), and the interaction term (age × MS × male sex) was significant (β = 1.00, P = .017). Metabolic syndrome is associated with muscle weakness, and this relationship is particularly pronounced in men. Age can modify the impact of MS on muscle strength. Men aged 65 to 74 years with MS need a thorough assessment of muscle strength to prevent disability.
authors.affiliation: Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, 463-707, South Korea.
authors.forename: Eun Joo
authors.initials: EJ
authors.lastname: Yang
authors.forename: Soo
authors.initials: S
authors.lastname: Lim
authors.forename: Jae-Young
authors.initials: JY
authors.lastname: Lim
authors.forename: Ki Woong
authors.initials: KW
authors.lastname: Kim
authors.forename: Hak Chul
authors.initials: HC
authors.lastname: Jang
authors.forename: Nam-Jong
authors.initials: NJ
authors.lastname: Paik
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D004522:Educational Status; D005260:Female; D018737:Hand Strength / Q000502:physiology; D006262:Health; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D024821:Metabolic Syndrome / Q000503:physiopathology* / Q000523:psychology; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology; D053580:Muscle Strength / Q000502:physiology*; D018908:Muscle Weakness / Q000453:epidemiology / Q000209:etiology; D009483:Neuropsychological Tests; D009929:Organ Size / Q000502:physiology; D056910:Republic of Korea / Q000453:epidemiology; D012727:Sex Characteristics; D012907:Smoking / Q000009:adverse effects; D014057:Tomography, X-Ray Computed; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose