title: [Neuroprotective role of silent information regulator 1 in Alzheimer's disease].
abstract: Silent information regulator 1 (SIRT1), an NAD(+)-dependent deacetylase, is involved in the regulation of gene transcription, energy metabolism and cell aging. Recent studies have showed that SIRT1 possesses neuroprotective effects, however, it is not very clear how SIRT1 exerts the neuroprotection in Alzheimer's disease (AD). In this review, we summarized the neuroprotective role of SIRT1 in AD and its possible molecular mechanisms, proposing a novel strategy for preventing and treating neurodegeneration.
authors.affiliation: Department of Physiology, National Key Disciplines, Key Laboratory for Cellular Physiology of Ministry of Education, Shanxi Medical University, Taiyuan 030001, China.
authors.forename: Xiao-Rong
authors.initials: XR
authors.lastname: Yang
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Hua-Ping
authors.initials: HP
authors.lastname: Qin
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.forename: Nai-Hong
authors.initials: NH
authors.lastname: Liu
authors.forename: Ce
authors.initials: C
authors.lastname: Zhang
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000503:physiopathology*; D000818:Animals; D004734:Energy Metabolism / Q000502:physiology; D006801:Humans; D018696:Neuroprotective Agents; D056564:Sirtuin 1 / Q000502:physiology*; D014158:Transcription, Genetic / Q000502:physiology
chemical_list: D018696:Neuroprotective Agents; C447939:SIRT1 protein, human; D056564:Sirtuin 1