title: Imaging multiple conductance states in an alamethicin pore.
abstract: Alamethicin is the archetypal antimicrobial pore-forming peptide. Although the peptide has long been known to form pores of characteristic conductances in lipid membranes, the precise nature of these pores is not known. Simultaneous calcium-flux imaging and single-channel recording in a droplet interface bilayer allowed us to directly attribute multiple conductance states to a single point diffusing in the bilayer.
authors.affiliation: Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.
authors.forename: Lydia M
authors.initials: LM
authors.lastname: Harriss
authors.forename: Bríd
authors.initials: B
authors.lastname: Cronin
authors.forename: James R
authors.initials: JR
authors.lastname: Thompson
authors.forename: Mark I
authors.initials: MI
authors.lastname: Wallace
mesh_terms: D000408:Alamethicin / Q000737:chemistry / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D004553:Electric Conductivity; D055664:Electrochemical Techniques; D008051:Lipid Bilayers / Q000737:chemistry / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D008051:Lipid Bilayers; D000408:Alamethicin; D002118:Calcium