title: Hormonal regulators of food intake and weight gain in Parkinson's disease after subthalamic nucleus stimulation.
abstract: OBJECTIVE
  Weight gain has been reported in patients with Parkinson's disease (PD) treated with deep brain stimulation of the subthalamic nucleus (STN-DBS). To evaluate the influence of STN-DBS on weight changes, we studied food-related hormones.
  
  
  METHODS
  Anthropometric parameters and food-related hormones (leptin, adiponectin, resistin, ghrelin, cortisol, insulin, and thyroid stimulating hormone) were measured in 27 patients with STN-DBS during a 12 month period following electrode implantation.
  
  
  RESULTS
  Besides marked motor improvements on STN-DBS, PD patients significantly gained weight. The mean weight gain at 12 months was 5.2±(SD)5.8 kg. A significant decrease in cortisol levels compared to baseline appeared at month 2 and persisted at 12 months (p<0.01, corrected), with no significant changes in other hormones tested.
  
  
  CONCLUSIONS
  Changes in peripheral food-related hormones do not appear to cause weight gain in PD patients. Direct effects of STN-DBS on hypothalamic catabolic/anabolic peptide balance remain hypothetical and necessitate further elucidation.
authors.affiliation: Department of Neurology and Centre of Clinical Neuroscience, Charles University, Prague, Czech Republic.
authors.forename: Lucie
authors.initials: L
authors.lastname: Novakova
authors.forename: Martin
authors.initials: M
authors.lastname: Haluzik
authors.forename: Robert
authors.initials: R
authors.lastname: Jech
authors.forename: Dusan
authors.initials: D
authors.lastname: Urgosik
authors.forename: Filip
authors.initials: F
authors.lastname: Ruzicka
authors.forename: Evzen
authors.initials: E
authors.lastname: Ruzicka
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D046690:Deep Brain Stimulation / Q000379:methods*; D004435:Eating / Q000502:physiology*; D005260:Female; D054439:Ghrelin / Q000097:blood; D006728:Hormones / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007031:Hypothalamus / Q000502:physiology; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000378:metabolism* / Q000628:therapy*; D052243:Resistin / Q000097:blood; D020531:Subthalamic Nucleus / Q000502:physiology*; D013972:Thyrotropin / Q000097:blood; D015430:Weight Gain / Q000502:physiology
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D054439:Ghrelin; D006728:Hormones; D007328:Insulin; D020738:Leptin; C499624:RETN protein, human; D052243:Resistin; D013972:Thyrotropin; D006854:Hydrocortisone