title: d(TGGGAG) with 5'-nucleobase-attached large hydrophobic groups as potent inhibitors for HIV-1 envelop proteins mediated cell-cell fusion.
abstract: The Hotoda's sequence substituted with TBDPS via 5'-end nucleobase existed as parallel quadruplex structure and exhibited inhibitory activities in an HIV-1 envelop proteins mediated cell-cell fusion assay. This result demonstrated that the 5'-aromatic groups of the Hotoda's sequence are allowed to have a large spatial freedom and remain to be optimized for its role in the binding to HIV-1 envelop proteins.
authors.affiliation: Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing 100850, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Liang
authors.initials: L
authors.lastname: Xu
authors.forename: Lifeng
authors.initials: L
authors.lastname: Cai
authors.forename: Baohua
authors.initials: B
authors.lastname: Zheng
authors.forename: Kun
authors.initials: K
authors.lastname: Wang
authors.forename: Junlin
authors.initials: J
authors.lastname: He
authors.forename: Keliang
authors.initials: K
authors.lastname: Liu
mesh_terms: D000595:Amino Acid Sequence; D001482:Base Composition; D002459:Cell Fusion; D054856:G-Quadruplexes; D023581:HIV Fusion Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008561:Membrane Fusion; D011485:Protein Binding; D013329:Structure-Activity Relationship; D054299:env Gene Products, Human Immunodeficiency Virus / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism
chemical_list: D023581:HIV Fusion Inhibitors; D054299:env Gene Products, Human Immunodeficiency Virus