title: Regio- and stereoselective synthesis of truncated 3'-aminocarbanucleosides and their binding affinity at the A3 adenosine receptor.
abstract: The stereoselective synthesis of truncated 3'-aminocarbanucleosides 4a-d via a stereo- and regioselective conversion of a diol 9 to bromoacetate 11a and their binding affinity towards the human A(3) adenosine receptor are described.
authors.affiliation: Laboratory of Medicinal Chemistry, College of Pharmacy and Department of Bioinspired Science, Ewha Womans University, Seoul, 120-750, Korea.
authors.forename: Mun Ju
authors.initials: MJ
authors.lastname: Choi
authors.forename: Girish
authors.initials: G
authors.lastname: Chandra
authors.forename: Hyuk Woo
authors.initials: HW
authors.lastname: Lee
authors.forename: Xiyan
authors.initials: X
authors.lastname: Hou
authors.forename: Won Jun
authors.initials: WJ
authors.lastname: Choi
authors.forename: Khai
authors.initials: K
authors.lastname: Phan
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Jacobson
authors.forename: Lak Shin
authors.initials: LS
authors.lastname: Jeong
mesh_terms: D000588:Amines / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D009705:Nucleosides / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding; D043684:Receptor, Adenosine A3 / Q000737:chemistry* / Q000378:metabolism; D013237:Stereoisomerism
chemical_list: D000588:Amines; D009705:Nucleosides; D043684:Receptor, Adenosine A3