title: [Correction of lipid peroxidation and antioxidant system disorders by bioflavonoids during modeling of cholesterol atherosclerosis in rabbits].
abstract: We have studied the influence of bioflavonoids (quercetin, corvitin) on lipid peroxidation and antioxidant enzymes in the modeling of cholesterol atherosclerosis in rabbits. It has been shown that simultaneous administration of the quercetin derivative corvitin suppressed lipid peroxidation. We showed that under hypercholesterolemia, the concentration of malone dialdehyde in myocardial tissue in rabbits is significantly increased, while administration of bioflavonoids decreased the concentration of malone dialdehyde by 38.3%. Furthermore, corvitin caused activating effects on antioxidant enzymes superoxide dismutase and catalase in cardiac tissue. Our data suggest that bioflavonoids are able to suppress lipid peroxidation and prevent the decrease ofantioxidant enzymes activity in rabbits with cholesterol-rich diet induced atherosclerosis.
authors.forename: A  M
authors.initials: A
authors.lastname: Shysh
authors.forename: D O
authors.initials: DO
authors.lastname: Pashevin
authors.forename: V Ie
authors.initials: VIe
authors.lastname: Dosenko
authors.forename: O O
authors.initials: OO
authors.lastname: Moĭbenko
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use*; D050197:Atherosclerosis / Q000188:drug therapy* / Q000201:enzymology / Q000209:etiology / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage / Q000009:adverse effects*; D004036:Diet, Atherogenic; D005260:Female; D005609:Free Radicals / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects*; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D009206:Myocardium / Q000378:metabolism; D011794:Quercetin / Q000008:administration & dosage / Q000627:therapeutic use*; D011817:Rabbits; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D002791:Cholesterol, Dietary; D005609:Free Radicals; D008054:Lipid Peroxides; D002784:Cholesterol; D011794:Quercetin; D002374:Catalase; D013482:Superoxide Dismutase