title: The expression and clinical significance of CLIC1 and HSP27 in lung adenocarcinoma.
abstract: The purpose of this research was to study the roles of chloride intracellular channel protein 1 (CLIC1) and heat shock protein 27 (HSP27) in the clinical pathology of lung adenocarcinoma and to explore whether the expression of CLIC1 and HSP27 can be used as independent factors for the prediction of recurrence and prognosis after radical resection of lung adenocarcinoma. One hundred and three paraffin sections of lung adenocarcinoma tissues were collected, and the expression of CLIC1 and HSP27 was detected in these tumors using immunohistochemistry. The correlation of the expression of these two proteins with clinicopathological parameters and prognosis was statistically analyzed. In the 103 samples, the expression of HSP27 and CLIC1 was strongly positive in 61 (59.2%) and 49 cases (47.6%), respectively. Statistical analysis showed that the expression level of HSP27 did not significantly correlate with the patient's age, sex, degree of tumor differentiation, T staging of tumors, and TNM staging of tumors (p > 0.05), whereas the expression of CLIC1 did significantly correlate with T staging of tumors (p = 0.029). Univariate analysis indicated that the patient's ECOG score, T staging, N staging, TNM staging, and CLIC1 expression correlated with prognosis (p = 0.031, 0.001, 0.011, 0.013, and <0.001, respectively). Multivariate statistical analysis showed that age, T staging, and CLIC1 expression were independent associated factors for predicting the 5-year survival rate of patients (p = 0.026, 0.004, and <0.001, respectively). Age, T staging, and CLIC1 expression significantly correlated with the overall survival of post-operative lung adenocarcinoma patients. CLIC1 may be closely associated with the occurrence and development of lung adenocarcinoma and may be used as an effective marker for predicting the prognosis of this disease.
authors.affiliation: Department of Cardiothoracic Surgery, The First Affiliated Hospital of Guangzhou Medical College, Guangzhou, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Xu
authors.forename: Wujun
authors.initials: W
authors.lastname: Wang
authors.forename: Wenlong
authors.initials: W
authors.lastname: Shao
authors.forename: Liping
authors.initials: L
authors.lastname: Li
authors.forename: Weiqiang
authors.initials: W
authors.lastname: Yin
authors.forename: Liangchang
authors.initials: L
authors.lastname: Xiu
authors.forename: Mingcong
authors.initials: M
authors.lastname: Mo
authors.forename: Jin
authors.initials: J
authors.lastname: Zhao
authors.forename: Qingyu
authors.initials: Q
authors.lastname: He
authors.forename: Jianxing
authors.initials: J
authors.lastname: He
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D016009:Chi-Square Distribution; D018118:Chloride Channels / Q000096:biosynthesis*; D005260:Female; D055551:HSP27 Heat-Shock Proteins / Q000096:biosynthesis*; D006360:Heat-Shock Proteins; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018832:Molecular Chaperones; D009367:Neoplasm Staging
chemical_list: D014408:Biomarkers, Tumor; C501966:CLIC1 protein, human; D018118:Chloride Channels; D055551:HSP27 Heat-Shock Proteins; C057725:HSPB1 protein, human; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones