title: Design, synthesis and destructive dynamic effects of BODIPY-containing and curcuminoid boron tracedrugs for neutron dynamic therapy.
abstract: BACKGROUND
  We previously designed the boron tracedrugs UTX-42, UTX-43, and UTX-44, which possess antioxidant potency. In order to explore their destructive dynamic effects when bombarded by weak thermal neutrons, we performed thermal neutron irradiation of bovine serum albumin (BSA) treated with the boron tracedrugs.
  
  
  METHODS
  Boron tracedrugs, including the boron dipyrromethene (BODIPY)-containing compounds UTX-42, UTX-44, and UTX-47 and the curcuminoid compounds UTX-50 and UTX-51, were designed for neutron dynamic therapy based on their molecular orbital calculation. Newly designed UTX-47, UTX-50, and UTX-51 were synthesized. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) was performed to detect decomposition by thermal neutron irradiation of BSA treated with these boron tracedrugs.
  
  
  RESULTS
  The combination of 1.0 μM BSA with 100 μM of each of the boron tracedrugs showed a decrease in band intensity after irradiation.
  
  
  CONCLUSIONS
  All boron tracedrugs tested caused destructive dynamic damage of BSA during thermal neutron irradiation, suggesting that boron tracedrugs could be used as dynamic drugs for neutron dynamic therapy.
authors.affiliation: Department of Life System, Institute of Technology and Science, Graduate School, The University of Tokushima, Minamijosanjimacho-2, Tokushima, 770-8506 Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Nakata
authors.forename: Masato
authors.initials: M
authors.lastname: Koizumi
authors.forename: Yohei
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Kenta
authors.initials: K
authors.lastname: Onaka
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Sakurai
authors.forename: Natsuko
authors.initials: N
authors.lastname: Kondo
authors.forename: Koji
authors.initials: K
authors.lastname: Ono
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Uto
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Hori
mesh_terms: D000818:Animals; D001896:Boron Compounds / Q000737:chemistry / Q000528:radiation effects*; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D002417:Cattle; D003474:Curcumin / Q000031:analogs & derivatives / Q000737:chemistry / Q000528:radiation effects*; D015195:Drug Design; D004591:Electrophoresis, Polyacrylamide Gel; D005720:Gamma Rays; D015394:Molecular Structure; D011838:Radiation-Sensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000528:radiation effects*; D012710:Serum Albumin, Bovine / Q000187:drug effects / Q000528:radiation effects; D013329:Structure-Activity Relationship
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D011838:Radiation-Sensitizing Agents; D012710:Serum Albumin, Bovine; D003474:Curcumin