title: Cerebellar atrophy is infrequently [corrected] associated with non-paraneoplastic sensory neuronopathy.
abstract: Sensory neuronopathies (SN) are peripheral nervous system disorders associated with degeneration of dorsal root ganglion neurons. Despite the evidence of a defective proprioceptive sensory input in SN,the prominent gait and truncal ataxia raises the question of a concomitant involvement of the cerebellum.
  
  
  OBJECTIVE
  To evaluate cerebellar atrophy in SN.
  
  
  METHODS
  We analyzed MRI-based volumetry of anterior lobe (paleocerebellum) and total cerebellum in patients with non-paraneoplastic chronic SN and compared to age- and gender-matched controls.
  
  
  RESULTS
  Cerebellum and anterior lobe MRI volumetry were performed in 20 patients and nine controls. Mean anterior lobe and cerebellar volume were not statistically different. Three patients (15%), however, had an abnormal anterior lobe and cerebellar volume index (values outside 2.5 standard deviations). One of them also had a specific atrophy of the anterior lobe. All these patients had infectious or dysimmune associated SN.
  
  
  CONCLUSIONS
  Cerebellar atrophy is infrequently associated with SN, but can be found in some patients with SN related to infectious or immune mediated conditions. It can be more prominent in the anterior lobe and may contribute to the ataxia seen in these patients.
authors.affiliation: Department of Neurology, State University of Campinas, Campinas, SP, Brazil. alfredodamasceno@hotmail.com
authors.forename: Alfredo
authors.initials: A
authors.lastname: Damasceno
authors.forename: Marcondes C
authors.initials: MC
authors.lastname: França
authors.forename: Fernando
authors.initials: F
authors.lastname: Cendes
authors.forename: Anamarli
authors.initials: A
authors.lastname: Nucci
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001284:Atrophy; D016022:Case-Control Studies; D002531:Cerebellum / Q000473:pathology*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000473:pathology*; D012189:Retrospective Studies; D055815:Young Adult