title: [Molecular physiology of receptor mediated endocytosis and its role in overcoming multidrug resistance].
abstract: Receptor-mediated endocytosis plays important role in the selective uptake of proteins at the plasma membrane of eukaryotic cells. Endocytosis regulates many processes of cell signalling by controlling the number of functional receptors on the cell surface. The article reviews the mechanism of clathrin-dependent endocytosis and the possibility of using this phenomenon for the targeted delivery of drugs. Use of certain proteins as targeting component of drug delivery systems can significantly improve the selectivity of this drug, as well as to overcome the multidrug resistance of cells resulting from the activity of the ABC-transporters.
authors.forename: E S
authors.initials: ES
authors.lastname: Severin
authors.forename: G A
authors.initials: GA
authors.lastname: Posypanova
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics / Q000378:metabolism; D033942:Adaptor Proteins, Vesicular Transport / Q000235:genetics / Q000502:physiology; D002462:Cell Membrane / Q000502:physiology; D002966:Clathrin / Q000235:genetics / Q000502:physiology*; D016503:Drug Delivery Systems; D018432:Drug Resistance, Multiple / Q000235:genetics / Q000502:physiology*; D019008:Drug Resistance, Neoplasm; D004705:Endocytosis / Q000235:genetics / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics; D018000:Receptors, Peptide / Q000235:genetics; D000509:alpha-Fetoproteins / Q000235:genetics / Q000502:physiology
chemical_list: D018528:ATP-Binding Cassette Transporters; D033942:Adaptor Proteins, Vesicular Transport; D002966:Clathrin; D018000:Receptors, Peptide; D000509:alpha-Fetoproteins; C042144:alpha-fetoprotein receptor, human