title: Strategies for extended serum half-life of protein therapeutics.
abstract: With a growing number of protein therapeutics being developed, many of them exhibiting a short plasma half-life, half-life extension strategies find increasing attention by the biotech and pharmaceutical industry. Extension of the half-life can help to reduce the number of applications and to lower doses, thus are beneficial for therapeutic but also economic reasons. Here, a comprehensive overview of currently developed half-life extension strategies is provided including those aiming at increasing the hydrodynamic volume of a protein drug but also those implementing recycling processes mediated by the neonatal Fc receptor.
authors.affiliation: Institut für Zellbiologie und Immunologie, Universität Stuttgart, Allmandring 31, 70569 Stuttgart, Germany. roland.kontermann@izi.uni-stuttgart.de
authors.forename: Roland E
authors.initials: RE
authors.lastname: Kontermann
mesh_terms: D050260:Carbohydrate Metabolism; D006031:Glycosylation; D006207:Half-Life; D006801:Humans; D057446:Hydrodynamics; D011092:Polyethylene Glycols / Q000378:metabolism; D015202:Protein Engineering; D011506:Proteins / Q000378:metabolism / Q000627:therapeutic use; D011994:Recombinant Proteins / Q000378:metabolism* / Q000627:therapeutic use; D044967:Serum / Q000378:metabolism*
chemical_list: D011506:Proteins; D011994:Recombinant Proteins; D011092:Polyethylene Glycols