title: Biocompatible drug delivery system for photo-triggered controlled release of 5-Fluorouracil.
abstract: The synthesis of a photo-triggered biocompatible drug delivery system on the basis of coumarin-functionalized block copolymers is reported. The coumarin-functionalized block copolymers poly(ethylene oxide)-b-poly(n-butyl methacrylate-co-4-methyl-[7-(methacryloyl)oxyethyloxy]coumarin)) (PEO-b-P(BMA- co-CMA)) were synthesized via atom transfer radical polymerization (ATRP). The micelle-drug conjugates were made by covalent bonding of anticancer drug 5-fluorouracil (5-FU) to the coumarin under UV irradiation at wavelength >310 nm. These micelle-drug conjugates possessed spherical morphology with diameters of 70 nm from TEM images. In vitro drug release experiments showed the controlled release of anticancer drug 5-FU from the micelle-drug conjugates under UV irradiation (254 nm). These micelle-drug conjugates also showed excellent biocompatibility by the in vitro cytotoxicity experiments. The results suggest that these micelle-drug conjugates could be a promising candidate for the delivery of anticancer agents with low side effects on normal cells and excellent therapeutic efficacy to cancer cells.
authors.affiliation: Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein Strasse, D-35032 Marburg, Germany.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Jin
authors.forename: Fabian
authors.initials: F
authors.lastname: Mitschang
authors.forename: Seema
authors.initials: S
authors.lastname: Agarwal
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism*; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000378:metabolism; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000138:chemical synthesis* / Q000378:metabolism; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000378:metabolism; D004339:Drug Compounding / Q000379:methods*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D005472:Fluorouracil / Q000737:chemistry / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D010316:Particle Size; D055668:Photochemical Processes / Q000528:radiation effects; D011092:Polyethylene Glycols / Q000737:chemistry*; D058105:Polymerization; D014466:Ultraviolet Rays
chemical_list: D000180:Acrylic Resins; D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008823:Micelles; C521061:polyethylene glycol-block-(coumarin methacrylate-co-methyl methacrylate); D011092:Polyethylene Glycols; D005472:Fluorouracil