title: Mitochondria DNA polymorphisms are associated with susceptibility to endometriosis.
abstract: Because energy production involves oxidative phosphorylation, mitochondria are major sources of reactive oxygen species in the cell. Recent findings indicate that mitochondrial DNA (mtDNA) variants may play a role in the etiology of certain autoimmune and chronic inflammatory diseases. The aim of this study was to investigate the possible association between mtDNA polymorphisms and susceptibility to endometriosis. This study included 198 patients with histologically confirmed endometriosis and 167 patients without endometriosis as controls. Common variants of mtDNA at nt10398 (A/G transition), nt13708 (G/A transition), and nt16189 (T/C transition) were detected using polymerase chain reaction. An association study was performed with a chi-square test and logistic regression analysis. The prevalence of the mtDNA nt16189 variant was higher in patients with endometriosis (46.0%, 91 of 198) than in controls (34.7%, 58 of 167) (p=0.030) with odds ratio (OR) of 1.98 (95% confidence interval [CI]: 1.04-3.78). A combination of the 10398 and 16189 variants was also associated with increased risk for endometriosis (OR=1.90, 95% CI: 1.13-3.18, p=0.015). These associations remained significant even after adjusting for age and body mass index. Our data strongly suggest that the mtDNA 16189 variants and the combination of mtDNA 16189 and 10398 variants increase susceptibility to endometriosis.
authors.affiliation: Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: SiHyun
authors.initials: S
authors.lastname: Cho
authors.forename: Young-Mock
authors.initials: YM
authors.lastname: Lee
authors.forename: Young Sik
authors.initials: YS
authors.lastname: Choi
authors.forename: Hyo In
authors.initials: HI
authors.lastname: Yang
authors.forename: Young Eun
authors.initials: YE
authors.lastname: Jeon
authors.forename: Kyung Eun
authors.initials: KE
authors.lastname: Lee
authors.forename: KyungJin
authors.initials: K
authors.lastname: Lim
authors.forename: Hye Yeon
authors.initials: HY
authors.lastname: Kim
authors.forename: Seok Kyo
authors.initials: SK
authors.lastname: Seo
authors.forename: Byung Seok
authors.initials: BS
authors.lastname: Lee
mesh_terms: D000328:Adult; D004272:DNA, Mitochondrial / Q000235:genetics*; D004715:Endometriosis / Q000235:genetics* / Q000473:pathology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D009367:Neoplasm Staging; D018384:Oxidative Stress; D020641:Polymorphism, Single Nucleotide; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D004272:DNA, Mitochondrial; D017382:Reactive Oxygen Species