title: Evaluation of the efficacy and safety of bromocriptine QR in type 2 diabetes.
abstract: BACKGROUND
  Diabetes mellitus is a chronic metabolic disorder of endocrinal origin with multiorgan involement. Today's physician has a lot many options to choose for treating type 2 diabetes, but does not always manages to achieve optimal glycemic control. The newer drug bromocriptine acts by novel hypothalamic circadian rhythm resetting mechanism.
  
  
  OBJECTIVE
  To evaluate the efficacy and safety of bromocriptine QR in type 2 diabetes.
  
  
  METHODS
  105 patients according to inclusion and exclusion criteria were randomized into three groups by simple randomization. Group 1 received bromocriprine 2.4 mg once daily, group 2 received metformin 500 mg twice daily while group 3 received bromocriprine 1.6 mg daily and metformin 500 mg twice daily. Baseline measurement of fasting and postprandial blood sugar, HbA1(C) and BMI were followed up at 6(th) and 12(th) weeks. Safety evaluation was done by questioning the patient and also through routine hematological and biochemical parameters. Z test was used for analysis.
  
  
  RESULTS
  Group 1 showed significant reduction in fasting and postprandial sugar and HbA(1c) at 12 weeks. While groups 2 and 3 showed even higher reduction in these parameters albeit with slightly more adverse drug events like nausea, vomiting compared to group 1.
  
  
  CONCLUSIONS
  Bromocriptine QR is an effective and safe antidiabetic drug which can be employed as monotherapy or in conjuction with metformin to achieve and maintain optimal glycemic control.
authors.affiliation: Department of Pharmacology, Government Medical College, Miraj, Maharashtra, India.
authors.forename: Karuna Balwant
authors.initials: KB
authors.lastname: Ramteke
authors.forename: Sunita Jaiprakash
authors.initials: SJ
authors.lastname: Ramanand
authors.forename: Jaiprakash B
authors.initials: JB
authors.lastname: Ramanand
authors.forename: Suyog Subhas
authors.initials: SS
authors.lastname: Jain
authors.forename: Girish Tulsidas
authors.initials: GT
authors.lastname: Raparti
authors.forename: Milind Hari
authors.initials: MH
authors.lastname: Patwardhan
authors.forename: Mangala
authors.initials: M
authors.lastname: Murthy
authors.forename: Ravi G
authors.initials: RG
authors.lastname: Ghanghas