title: [Cardiotropic activity of synthetic peptide CH3CO-Lys-Lys-Arg-Arg-NH2 (protectin)].
abstract: Peptide CH3CO-Lys-Lys-Arg-Arg-NH2 (protectin) was synthesized and its activity was studied on the model of experimental myocardial infarction in rats in comparison to the reference antihypoxant drug riboxin. Intranasal injections ofprotectin at doses within 2-20 microg/kg once a day by course of 7 days produced a pronounced anti-ischemic action, improved coronary circulation of the blood, increases contractile activity of myocardium, reduced intensity of lipid peroxidation, and improved antioxidant protection. In some respects (improved coronary circulation of the blood, increased antioxidant protection), protectin was more effective than riboxin.
authors.forename: A I
authors.initials: AI
authors.lastname: Sazhin
authors.forename: M A
authors.initials: MA
authors.lastname: Zaĭtseva
authors.forename: M E
authors.initials: ME
authors.lastname: Melikhova
authors.forename: N F
authors.initials: NF
authors.lastname: Ezhov
authors.forename: V B
authors.initials: VB
authors.lastname: Sadovnikov
authors.forename: E V
authors.initials: EV
authors.lastname: Navolotskaia
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D003326:Coronary Circulation / Q000187:drug effects; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D007290:Inosine Diphosphate / Q000008:administration & dosage*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy*; D009842:Oligopeptides / Q000008:administration & dosage / Q000138:chemical synthesis; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000975:Antioxidants; D009842:Oligopeptides; C548117:Protektin; D007290:Inosine Diphosphate