title: Primary synovial sarcoma of kidney-a report of 2 cases and review of literature.
abstract: BACKGROUND
  Primary kidney sarcomas are rare neoplasms. Pre-operative signs and symptoms are non-specific, thus making early diagnosis of this condition difficult. The presenting features are similar to other common renal tumors.
  
  
  METHODS
  Two cases of primary renal synovial sarcoma were diagnosed based on histopathology and immunohistochemistry (IHC). Fusion gene product analysis was also done for one patient.
  
  
  RESULTS
  Both patients underwent radical nephrectomy. The morphology and IHC of the tumors were consistent with primary synovial sarcoma of the kidney. One of the patients received adjuvant chemotherapy and is on regular follow-up since two years. The second patient was lost to follow-up.
  
  
  CONCLUSIONS
  These tumors should be correctly diagnosed because the line of treatment is distinct from primary renal cell carcinoma. Chemotherapy has a role in managing these patients.
  
  
  BACKGROUND
  Synovial sarcoma - kidney - RT-PCR - SYTSSX - t (X;18) translocation - Fusion gene..
authors.affiliation: The Departments of Medical Oncology , Kidwai Memorial Institute of Oncology, Bangalore, India.
authors.forename: K C
authors.initials: KC
authors.lastname: Lakshmaiah
authors.forename: Kamal S
authors.initials: KS
authors.lastname: Saini
authors.forename: Tejinder
authors.initials: T
authors.lastname: Singh
authors.forename: Ankit
authors.initials: A
authors.lastname: Jain
authors.forename: Rekha V
authors.initials: RV
authors.lastname: Kumar
authors.forename: Sajeevan K
authors.initials: SK
authors.lastname: V
authors.forename: Lokanatha
authors.initials: L
authors.lastname: D
authors.forename: L Abraham
authors.initials: LA
authors.lastname: Jacob