title: Trisomy 8 in Philadelphia chromosome negative cell preceding the evolution of a Philadelphia chromosome positive clone with the same additional change during imatinib treatment: revisiting the role of genetic instability in chronic myeloid leukemia.
authors.forename: Laura
authors.initials: L
authors.lastname: Cannella
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Loglisci
authors.forename: Mauro
authors.initials: M
authors.lastname: Nanni
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: De Cuia
authors.forename: Gioia
authors.initials: G
authors.lastname: Colafigli
authors.forename: Adriano
authors.initials: A
authors.lastname: Salaroli
authors.forename: Alessandra
authors.initials: A
authors.lastname: Serrao
authors.forename: Giuliana
authors.initials: G
authors.lastname: Alimena
authors.forename: Massimo
authors.initials: M
authors.lastname: Breccia
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001549:Benzamides; D002851:Chromatography, High Pressure Liquid; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D002999:Clone Cells / Q000378:metabolism / Q000473:pathology; D004252:DNA Mutational Analysis; D000069439:Dasatinib; D042822:Genomic Instability; D006801:Humans; D000068877:Imatinib Mesylate; D017404:In Situ Hybridization, Fluorescence; D015466:Leukemia, Myeloid, Chronic-Phase / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D058990:Molecular Targeted Therapy; D010677:Philadelphia Chromosome; D010879:Piperazines / Q000627:therapeutic use*; D011289:Preleukemia / Q000235:genetics / Q000473:pathology; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D060888:Real-Time Polymerase Chain Reaction; D012641:Selection, Genetic; D013844:Thiazoles / Q000627:therapeutic use; D014314:Trisomy
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D013844:Thiazoles; D000068877:Imatinib Mesylate; D000069439:Dasatinib