title: Recognizing nucleotides by cross-tunneling currents for DNA sequencing.
abstract: Using first-principles calculations, we study electron transport through nucleotides inside a rectangular nanogap formed by two pairs of gold electrodes which are perpendicular and parallel to the nucleobase plane. We propose that this setup will enhance the nucleotide selectivity of tunneling signals to a great extent. Information from three electrical probing processes offers full nucleotide recognition, which survives the noise from neighboring nucleotides and configuration fluctuations.
authors.affiliation: Research Center for Applied Sciences, Academia Sinica, Taipei 11529, Taiwan.
authors.forename: V M K
authors.initials: VM
authors.lastname: Bagci
authors.forename: Chao-Cheng
authors.initials: CC
authors.lastname: Kaun
mesh_terms: D001703:Biophysics / Q000379:methods*; D003198:Computer Simulation; D004277:DNA, Single-Stranded / Q000737:chemistry; D004553:Electric Conductivity; D004563:Electrochemistry / Q000379:methods*; D004566:Electrodes; D004579:Electron Transport; D006046:Gold; D008956:Models, Chemical; D008958:Models, Molecular; D009711:Nucleotides / Q000737:chemistry*; D017422:Sequence Analysis, DNA / Q000379:methods*
chemical_list: D004277:DNA, Single-Stranded; D009711:Nucleotides; D006046:Gold