title: Postvaccination morphea profunda in a child.
abstract: We report a new case of postvaccination morphea profunda (MP) in a child and discuss its different clinical presentations, prognosis, and therapy and its relationship with "solitary morphea profunda." A 2-year-old healthy girl presented with an induration of the anterior aspect of the left thigh of 9 months duration. The lesion had appeared 3 months after a third dose of diphtheria-tetanus-pertussis vaccine. Cutaneous examination showed an induration of 7 × 7 cm with an "orange peel" texture after pinching the skin. Histologic examination confirmed the diagnosis of MP. Systemic steroids (1 mg/kg/day) led to the stabilization of the lesion. After 4 months of treatment, we began the concomitant use of oral methotrexate (10 mg/wk) for 2 months. Methotrexate was then continued alone for 10 months, leading to a significant regression of the induration with no relapse.
authors.affiliation: Department of Dermatology, Charles Nicolle Hospital, Tunis, Tunisia. aida.khaled@rns.tn
authors.forename: Aida
authors.initials: A
authors.lastname: Khaled
authors.forename: Monia
authors.initials: M
authors.lastname: Kharfi
authors.forename: Anissa
authors.initials: A
authors.lastname: Zaouek
authors.forename: Soumaya
authors.initials: S
authors.lastname: Rameh
authors.forename: Rachida
authors.initials: R
authors.lastname: Zermani
authors.forename: Becima
authors.initials: B
authors.lastname: Fazaa
authors.forename: Mohamed Ridha
authors.initials: MR
authors.lastname: Kamoun
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D002675:Child, Preschool; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage* / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008727:Methotrexate / Q000627:therapeutic use; D012594:Scleroderma, Localized / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D013256:Steroids / Q000627:therapeutic use; D013848:Thigh
chemical_list: D000964:Antimetabolites, Antineoplastic; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D013256:Steroids; D008727:Methotrexate