title: Animal models for the study of arterial hypertension.
abstract: Hypertension is one of the leading causes of disability or death due to stroke, heart attack and kidney failure. Because the etiology of essential hypertension is not known and may be multifactorial, the use of experimental animal models has provided valuable information regarding many aspects of the disease, which include etiology, pathophysiology, complications and treatment. The models of hypertension are various, and in this review, we provide a brief overview of the most widely used animal models, their features and their importance.
authors.affiliation: Research in Biological Sciences-NUPEB, School of Nutrition, Ouro Preto University, Minas Gerais, Brazil.
authors.forename: Waleska C
authors.initials: WC
authors.lastname: Dornas
authors.forename: Marcelo E
authors.initials: ME
authors.lastname: Silva
mesh_terms: D000818:Animals; D003714:Denervation / Q000009:adverse effects; D004032:Diet / Q000009:adverse effects; D004195:Disease Models, Animal; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000235:genetics / Q000503:physiopathology*; D006977:Hypertension, Renal / Q000209:etiology / Q000235:genetics / Q000503:physiopathology*; D023421:Models, Animal; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000378:metabolism; D011311:Pressoreceptors / Q000601:surgery; D051381:Rats; D020303:Rats, Inbred Dahl; D011918:Rats, Inbred SHR; D055647:Rats, Transgenic
chemical_list: D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester