title: Weber's law for biological responses in autocatalytic networks of chemical reactions.
abstract: Biological responses often obey Weber's law, according to which the magnitude of the response depends only on the fold change in the external input. In this study, we demonstrate that a system involving a simple autocatalytic reaction shows such a response when a chemical is slowly synthesized by the reaction from a faster influx process. We also show that an autocatalytic reaction process occurring in series or in parallel can obey Weber's law with an oscillatory adaptive response. Considering the simplicity and ubiquity of the autocatalytic process, our proposed mechanism is thought to be commonly observed in biological reactions.
authors.affiliation: Cybermedia Center, Osaka University, Toyonaka, Osaka 560-0043, Japan.
authors.forename: Masayo
authors.initials: M
authors.lastname: Inoue
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Kaneko
mesh_terms: D055162:Biocatalysis; D007700:Kinetics; D008954:Models, Biological