title: The changes of blood glucose control and lipid profiles after short-term smoking cessation in healthy males.
abstract: OBJECTIVE
  Our aim was to evaluate the changes in blood glucose control and lipid profiles after 2-months of smoking cessation in healthy males.
  
  
  METHODS
  Smoking abstinence was evaluated through self-report and urine cotinine levels. 12 individuals who succeeded in quitting smoking were analyzed. Fasting values of glucose and insulin were used to estimate the β-cell activity and insulin resistance was evaluated using the Homeostasis Model Assessment (HOMA) and Quantitative Insulin Sensitivity Check Index (QUICKI).
  
  
  RESULTS
  The data showed that the subjects had a significant increase in weight, body mass index and fasting plasma glucose levels after smoking cessation. The HOMA-Insulin Resistance and the HOMA β-cell function increased significantly (p=0.005, p=0.047 respectively). The QUICKI showed a significant decrease (p=0.005). In addition, the low-density lipoprotein cholesterol levels decreased significantly (p=0.028); however, changes in the high-density lipoprotein cholesterol, the triglyceride and total cholesterol levels were not significant (p=0.284, p=0.445 respectively).
  
  
  CONCLUSIONS
  During the initial stage of smoking abstinence, insulin resistance increased and insulin sensitivity decreased due to elevated body weight and fat composition. Therefore, it is important to educate individuals that stop smoking about the necessity of weight control during smoking cessation programs.
authors.affiliation: Department of Endocrinology and Metabolism, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Bucheon, Korea.
authors.forename: Seong-Su
authors.initials: SS
authors.lastname: Lee
authors.forename: Jeong-Seok
authors.initials: JS
authors.lastname: Seo
authors.forename: Sung-Rae
authors.initials: SR
authors.lastname: Kim
authors.forename: Jo-Eun
authors.initials: JE
authors.lastname: Jeong
authors.forename: Beom-Woo
authors.initials: BW
authors.lastname: Nam
authors.forename: Ju-Yul
authors.initials: JY
authors.lastname: Lee
authors.forename: Hee-Jin
authors.initials: HJ
authors.lastname: Lee
authors.forename: Chul
authors.initials: C
authors.lastname: Lee
authors.forename: Chang-Uk
authors.initials: CU
authors.lastname: Lee
authors.forename: In-Ho
authors.initials: IH
authors.lastname: Paik
authors.forename: Jeong-Ho
authors.initials: JH
authors.lastname: Chae
authors.forename: Sook-Hee
authors.initials: SH
authors.lastname: Chai
authors.forename: Soon-Jib
authors.initials: SJ
authors.lastname: Yoo
authors.forename: Wang-Youn
authors.initials: WY
authors.lastname: Won
authors.forename: Dai-Jin
authors.initials: DJ
authors.lastname: Kim