title: Fragrance material review on 3-phenylpropyl isobutyrate.
abstract: A toxicologic and dermatologic review of 3-phenylpropyl isobutyrate when used as a fragrance ingredient is presented. 3-Phenylpropyl isobutyrate is a member of the fragrance structural group cinnamyl phenylpropyl compounds. The common characteristic structural element of cinnamyl phenylpropyl materials is an aryl substituted primary alcohol/aldehyde/ester. They are simple aromatic compounds with saturated propyl or unsaturated propenyl side chains containing a primary oxygenated functional group which has little toxic potential. 3-Phenyl-1-propyl derivatives participate in the same beta oxidation pathways as do their parent cinnamic acid derivatives. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 3-phenylpropyl isobutyrate was evaluated then summarized and includes physical properties, acute toxicity, skin irritation and skin sensitization. A safety assessment of all cinnamyl phenyl propyl compounds will be published simultaneously with this document. Please refer to Belsito et al. (2011) for an overall assessment of the safe use of this material and all cinnamyl phenylpropyl materials in fragrances. Belsito, D., Bickers, D., Bruze, M., Dagli, M.L., Fryer, A., Greim, H., Miyachi, Y., Saurat, J.H., Sipes, I.G., 2011. A toxicologic and dermatologic assessment of cinnamyl phenylpropyl compounds when used as fragrance ingredients.
authors.affiliation: Research Institute for Fragrance Materials, Inc. 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA. sbhatia@rifm.org
authors.forename: S P
authors.initials: SP
authors.lastname: Bhatia
authors.forename: J
authors.initials: J
authors.lastname: Cocchiara
authors.forename: G A
authors.initials: GA
authors.lastname: Wellington
authors.forename: J
authors.initials: J
authors.lastname: Lalko
authors.forename: C S
authors.initials: CS
authors.lastname: Letizia
authors.forename: A M
authors.initials: AM
authors.lastname: Api
mesh_terms: D000818:Animals; D002934:Cinnamates / Q000737:chemistry* / Q000633:toxicity*; D004249:DNA Damage / Q000187:drug effects; D017449:Dermatitis, Allergic Contact / Q000473:pathology; D017484:Dermatitis, Phototoxic / Q000473:pathology; D005131:Eye Injuries / Q000139:chemically induced / Q000473:pathology; D006801:Humans; D058610:Isobutyrates / Q000737:chemistry / Q000633:toxicity*; D009812:Odorants; D000439:Pentanols / Q000737:chemistry / Q000633:toxicity; D010476:Perfume / Q000737:chemistry* / Q000633:toxicity*; D012867:Skin / Q000187:drug effects / Q000473:pathology; D018675:Toxicity Tests
chemical_list: D002934:Cinnamates; D058610:Isobutyrates; D000439:Pentanols; D010476:Perfume; C571595:3-phenylpropyl isobutyrate