title: [Pharmacokinetics of domestic actoprotector drug Metaprot in healthy volunteers].
abstract: Pharmacokinetics of the actoprotector Metaprot, an original Russian drug, has been studied in a group of healthy adult volunteers. Metaprot in capsules was administrated orally as a single dose of 250 mg. The concentration of the active substance (ethylthiobenzimidazole) in the blood serum was determined by high-performance liquid chromatography (HPLC) with UV detection. The pharmacokinetic parameters were calculated by the model-independent method. The peak concentration of ethylthiobenzimidazole in plasma was Cmax = 0.91 +/- 1.05 microg/ml and the average time to peak concentration was t(max) = 1.06 +/- 0.16 h. A polymodal character of the distribution of pharmacokinetic parameters in the test group was revealed.
authors.forename: D A
authors.initials: DA
authors.lastname: Kibal'chich
authors.forename: V G
authors.initials: VG
authors.lastname: Belolipetskaia
authors.forename: S V
authors.initials: SV
authors.lastname: Blagodatskikh
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Martsevich
authors.forename: L I
authors.initials: LI
authors.lastname: Rudenko
authors.forename: V R
authors.initials: VR
authors.lastname: Iatsuk
mesh_terms: D000284:Administration, Oral; D000328:Adult; D019540:Area Under Curve; D001562:Benzimidazoles / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D002561:Cerebrovascular Disorders / Q000534:rehabilitation; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D012426:Russia; D013001:Somatoform Disorders / Q000534:rehabilitation; D055815:Young Adult
chemical_list: D001562:Benzimidazoles; C049825:bemethyl