title: Efficacy of vitamins supplementation to therapy on Helicobacter pylori eradication in patients with low antioxidant capacity.
abstract: OBJECTIVE
  It was shown that supplementation of vitamins C and E to therapy increased Helicobacter pylori eradication rate. In the present study, we aimed to evaluate whether supplementation of antioxidant vitamins to therapy increases H. pylori eradication rates in patients with chronic stress and low antioxidant capacity.
  
  
  METHODS
  This study included 120 patients who presented to gastroenterology outpatient clinic with H. pylori-positive nonulcer dyspepsia and low total antioxidant capacity. Patients in group A (n=80) were given lansoprazole (30 mg, BID), amoxicillin (1000 mg, BID), and clarithromycin (500 mg, BID) for 14 days, as well as vitamin C (500 mg, BID) and vitamin E (200 IU, BID) for 30 days. Patients in group B (n=40) were given lansoprazole (30 mg, BID), amoxicillin (1000 mg, BID), and clarithromycin (500 mg, BID) for 14 days.
  
  
  RESULTS
  Total antioxidant capacity were lower than normal levels in all patients. One hundred and fifteen patients (77 in group A, 38 in group B) were analyzed with per protocol analysis. In group A, H. pylori eradication was achieved in 63.8% of the patients included in the intention to treat analysis and in 66.2% of the patients included in the per protocol analysis. In group B, H. pylori eradication was achieved in 42.5% of the patients included in the intention to treat analysis and in 44.7% of the patients included in the per protocol analysis. Eradication rates were significantly higher in group A than in group B (P<0.005).
  
  
  CONCLUSIONS
  Supplementation with vitamins C and E increased H. pylori eradication rate of standard triple therapy.
authors.affiliation: Kocaeli Derince Education and Research Hospital, Gastroenterology, Kocaeli, Turkey. drsezikli@hotmail.com
authors.forename: Mesut
authors.initials: M
authors.lastname: Sezikli
authors.forename: Züleyha Akkan
authors.initials: ZA
authors.lastname: Cetinkaya
authors.forename: Fatih
authors.initials: F
authors.lastname: Güzelbulut
authors.forename: Hayrünnisa
authors.initials: H
authors.lastname: Sezikli
authors.forename: Selvinaz
authors.initials: S
authors.lastname: Özkara
authors.forename: Süleyman
authors.initials: S
authors.lastname: Coşgun
authors.forename: Can
authors.initials: C
authors.lastname: Gönen
authors.forename: Ayşe Oya Kurdaş
authors.initials: AO
authors.lastname: Övünç
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use*; D019587:Dietary Supplements; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000378:metabolism; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D014810:Vitamin E / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D001205:Ascorbic Acid