title: In vitro modeling of central nervous system myelination and remyelination.
abstract: This review aims to summarize the current techniques to study myelination and remyelination in culture systems. We attempt to put these into historical context, and to identify the strengths and weaknesses of each approach, which vary depending on the experimental question to be tested. We discuss the difficulty and importance of quantification of myelination and in particular remyelination. Finally, we provide our predictions of how these techniques will and should develop in the future.
authors.affiliation: MRC Centre for Regenerative Medicine, Edinburgh MS Centre, Queen's Medical Research Centre, Little France Crescent, Edinburgh, UK.
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Jarjour
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Nina
authors.initials: N
authors.lastname: Bauer
authors.forename: Charles
authors.initials: C
authors.lastname: Ffrench-Constant
authors.forename: Anna
authors.initials: A
authors.lastname: Williams
mesh_terms: D000818:Animals; D002478:Cells, Cultured / Q000502:physiology; D002493:Central Nervous System Diseases / Q000150:complications* / Q000473:pathology; D003711:Demyelinating Diseases / Q000150:complications*; D006801:Humans; D008954:Models, Biological; D009186:Myelin Sheath / Q000502:physiology*; D055495:Neurogenesis / Q000502:physiology*