title: Azaphenanthrene alkaloids with antitumoral activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae).
abstract: Phytochemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith led to isolation of three azaphenanthrene alkaloids: eupolauramine, sampangine and imbiline 1. Their chemical structures were established on the basis of spectroscopic data from IR, HR-ESI-MS, NMR (including 2D experiments) and comparison with the literature. Sampangine and imbiline 1 are being described in the Anaxagorea genus for the first time. Eupolauramine and sampangine show concentration-dependent antitumoral activity in leukemic cells K562 with IC(50) of 18.97 and 10.95 µg/mL, respectively.
authors.affiliation: Laboratory of Pharmaceutical Technology, Federal University of Paraiba, João Pessoa, PB, Brazil. asilviasuassuna@gmail.com
authors.forename: Ana Silvia Suassuna Carneiro
authors.initials: AS
authors.lastname: Lúcio
authors.forename: Jackson Roberto Guedes da Silva
authors.initials: JR
authors.lastname: Almeida
authors.forename: José Maria
authors.initials: JM
authors.lastname: Barbosa-Filho
authors.forename: João Carlos Lima Rodrigues
authors.initials: JC
authors.lastname: Pita
authors.forename: Marianna Vieira Sobral Castello
authors.initials: MV
authors.lastname: Branco
authors.forename: Margareth de Fátima Formiga Melo
authors.initials: Mde F
authors.lastname: Diniz
authors.forename: Maria de Fátima
authors.initials: Mde F
authors.lastname: Agra
authors.forename: Emidio V L
authors.initials: EV
authors.lastname: da-Cunha
authors.forename: Marcelo Sobral
authors.initials: MS
authors.lastname: da Silva
authors.forename: Josean Fechine
authors.initials: JF
authors.lastname: Tavares
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029061:Annonaceae / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001372:Aza Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D009287:Naphthyridines; D010616:Phenanthrenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D001372:Aza Compounds; D006576:Heterocyclic Compounds, 4 or More Rings; D009287:Naphthyridines; D010616:Phenanthrenes; D010936:Plant Extracts; C447626:eupolauramine; C121572:sampangine