title: Spirocyclic systems derived from pyroglutamic acid.
abstract: The synthesis and likely conformational structure of rigid spirocyclic bislactams and lactam-lactones derived from pyroglutamic acid, and their suitability as lead structures for applications in drug development programmes using cheminformatic analysis, has been investgated.
authors.affiliation: Department of Chemistry, Chemistry Research Laboratory, The University of Oxford, Mansfield Road, Oxford, UK OX1 3TA.
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Cowley
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Hill
authors.forename: Petr
authors.initials: P
authors.lastname: Kocis
authors.forename: Mark G
authors.initials: MG
authors.lastname: Moloney
authors.forename: Robert D
authors.initials: RD
authors.lastname: Stevenson
authors.forename: Amber L
authors.initials: AL
authors.lastname: Thompson
mesh_terms: D003500:Cyclization; D007769:Lactams / Q000138:chemical synthesis; D007783:Lactones / Q000138:chemical synthesis; D008958:Models, Molecular; D015394:Molecular Structure; D011761:Pyrrolidonecarboxylic Acid / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis*
chemical_list: D007769:Lactams; D007783:Lactones; D013141:Spiro Compounds; D011761:Pyrrolidonecarboxylic Acid