title: Synthesis of new riminophenazines with pyrimidine and pyrazine substitution at the 2-N position.
abstract: New riminophenazines with pyrimidine and pyrazine substituents at the 2-position were successfully synthesized. The key step is the 2-N-arylation of riminophenazines with pyrimidine and pyrazine. The optimized reaction conditions involve the use of a Pd₂(dba)₃/DPPF/Cs₂CO₃/toluene combination.
authors.affiliation: Department of Medicinal Chemistry, Beijing Key Laboratory of Active Substance Discovery and Drugability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing 100050, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Zhang
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.forename: Xiaojian
authors.initials: X
authors.lastname: Wang
authors.forename: Chun
authors.initials: C
authors.lastname: Li
authors.forename: Haihong
authors.initials: H
authors.lastname: Huang
authors.forename: Dali
authors.initials: D
authors.lastname: Yin
mesh_terms: D000995:Antitubercular Agents / Q000032:analysis / Q000138:chemical synthesis*; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000254:growth & development; D010165:Palladium / Q000737:chemistry; D010619:Phenazines / Q000032:analysis / Q000138:chemical synthesis*; D011719:Pyrazines / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry*; D014376:Tuberculosis / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D010619:Phenazines; D011719:Pyrazines; D011743:Pyrimidines; D010165:Palladium