title: Dramatic changes of a DWI lesion in a patient with acute ischemic stroke treated with IV t-PA.
abstract: A diffusion-weighted imaging (DWI) lesion changed dramatically in a hyperacute stroke case treated with intravenous tissue-plasminogen activator (IV t-PA). The initial hyperintense lesion on DWI disappeared completely immediately after IV t-PA treatment without improvement of neurological symptoms. However, the lesion reappeared 24 hours later. Successful thrombolysis can resolve DWI lesions but does not always improve the neurological symptoms.
authors.affiliation: Kawasaki Medical School-Stroke Medicine, Kurashiki, Japan. ysakamoto02@gmail.com
authors.forename: Yuki
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: Kazumi
authors.initials: K
authors.lastname: Kimura
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Iguchi
authors.forename: Kensaku
authors.initials: K
authors.lastname: Shibazaki
authors.forename: Junya
authors.initials: J
authors.lastname: Aoki
mesh_terms: D000369:Aged, 80 and over; D001921:Brain / Q000187:drug effects* / Q000473:pathology*; D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005343:Fibrinolytic Agents / Q000008:administration & dosage; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D009422:Nervous System Diseases / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D020521:Stroke / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator