title: Resveratrol in the prevention and treatment of coronary artery disease.
abstract: Resveratrol is a polyphenolic compound found in red wine that is believed to be responsible for its beneficial cardiovascular effects. Extensive research in the past several decades has identified multiple mechanisms by which resveratrol modifies the cardiovascular risk factors that lead to coronary artery disease, yet translation to the clinical arena has been unexpectedly slow. In this article, we review the existing evidence regarding the beneficial effects of resveratrol and briefly discuss its potential therapeutic applications.
authors.affiliation: Division of Cardiothoracic Surgery, Department of Surgery, Warren Alpert Medical School of Brown University, Providence, RI, USA.
authors.forename: Louis M
authors.initials: LM
authors.lastname: Chu
authors.forename: Antonio D
authors.initials: AD
authors.lastname: Lassaletta
authors.forename: Michael P
authors.initials: MP
authors.lastname: Robich
authors.forename: Frank W
authors.initials: FW
authors.lastname: Sellke
mesh_terms: D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects; D003324:Coronary Artery Disease / Q000503:physiopathology / Q000517:prevention & control* / Q000628:therapy; D006801:Humans; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood; D008264:Macrophages / Q000502:physiology; D024821:Metabolic Syndrome / Q000503:physiopathology / Q000628:therapy; D009131:Muscle, Smooth, Vascular / Q000502:physiology; D015425:Myocardial Reperfusion; D058226:Plaque, Atherosclerotic / Q000503:physiopathology; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use*; D013927:Thrombosis / Q000503:physiopathology; D014920:Wine
chemical_list: D008055:Lipids; D013267:Stilbenes; D000077185:Resveratrol