title: Triterpenes and triterpenoid saponins from the leaves of Ilex kudincha.
abstract: One new triterpene, kudinchalactone A (1), and four new triterpenoid saponins, ilekudinchosides A-D (2- 5), were isolated from the leaves of Ilex kudincha C. J. Tseng along with eight known triterpenoids. These new compounds were elucidated by spectroscopic methods including 1D and 2D NMR, HR-TOF-MS, and CD spectra. Compounds 2, 3, 12, and 13 showed antibacterial activities against Staphylococcus aureus (SA) and methicillin-resistant Staphylococcus aureus (MRSA).
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, P. R. China.
authors.forename: Wen-Jian
authors.initials: WJ
authors.lastname: Zuo
authors.forename: Hao-Fu
authors.initials: HF
authors.lastname: Dai
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Hui-Qin
authors.initials: HQ
authors.lastname: Chen
authors.forename: You-Xing
authors.initials: YX
authors.lastname: Zhao
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Mei
authors.forename: Xian
authors.initials: X
authors.lastname: Li
authors.forename: Jin-Hui
authors.initials: JH
authors.lastname: Wang
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D030017:Ilex / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D004365:Drugs, Chinese Herbal; D012503:Saponins; D014315:Triterpenes; C579585:ilekudinchoside A; C579586:kudinchalactone A