title: Elevated YB-1 expression is a new unfavorable prognostic factor in non-Hodgkin's lymphomas.
abstract: BACKGROUND
  Y-Box-binding protein-1 (YB-1) acts as a transcription factor for multiple genes and is linked to DNA replication and repair, cell proliferation and resistance to cytostatic drugs.
  
  
  METHODS
  The prognostic value of YB-1 expression in primarily untreated malignant non-Hodgkin's lymphomas (NHLs) was examined using immunohistochemistry.
  
  
  RESULTS
  Expression of YB-1 was detected in 48 out of 56 NHLs, and the immunohistochemical reaction was localized exclusively in the cytoplasm. Expression of YB-1 did not correlate with clinicopathological variables. Patients with higher YB-1 expression had shorter progression-free survival during the entire period of observation (p=0.0434), as well as in the course of 30 months' observation (p=0.0253). Additionally, in the course of 50 months' observation, patients with higher expression of YB-1 demonstrated a shorter overall survival time (p=0.0383) and a shorter progression-free survival (p=0.0309).
  
  
  CONCLUSIONS
  Elevated YB-1 expression may represent a new unfavorable prognostic factor.
authors.affiliation: Department of Histology and Embryology, Wroclaw Medical University, Wroclaw, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Szczuraszek
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Halon
authors.forename: Verena
authors.initials: V
authors.lastname: Materna
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Mazur
authors.forename: Tomasz
authors.initials: T
authors.lastname: Wrobel
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Kuliczkowski
authors.forename: Piotr
authors.initials: P
authors.lastname: Donizy
authors.forename: Per S
authors.initials: PS
authors.lastname: Holm
authors.forename: Hermann
authors.initials: H
authors.lastname: Lage
authors.forename: Pawel
authors.initials: P
authors.lastname: Surowiak
mesh_terms: D000328:Adult; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D051840:Y-Box-Binding Protein 1 / Q000378:metabolism*
chemical_list: D051840:Y-Box-Binding Protein 1; C070856:YBX1 protein, human