title: Plasma omentin-1 levels are reduced in non-obese women with normal glucose tolerance and polycystic ovary syndrome.
abstract: OBJECTIVE
  Omentin-1 is a novel adipokine that increases insulin sensitivity and is expressed in visceral adipose tissue. The aim of this study was to determine the metabolic parameters that influence plasma omentin-1 levels in women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  A cross-sectional study was performed in 87 women with PCOS and 53 body mass index (BMI)-matched healthy controls including 39 non-obese, normal-weight (NW) PCOS women with normal glucose tolerance (NGT) and 44 BMI- and homeostasis model assessment (HOMA)-matched controls. Indices of insulin sensitivity, metabolic variables, circulating androgen levels, serum adiponectin, and omentin-1 levels were measured. A 75 g oral glucose tolerance test was performed in all participants.
  
  
  RESULTS
  Plasma omentin-1 levels were significantly lower in women with PCOS compared with those in BMI-matched controls (P<0.001). A significantly lower level of plasma omentin-1 was observed in non-obese women with PCOS and NGT compared with that in BMI- and HOMA-matched controls (P<0.001). Omentin-1 level was negatively correlated with BMI, indices of insulin sensitivity, and circulating androgens and was associated with greater 2 h postprandial glucose, C-peptide, and insulin levels compared with fasting values. Within the NW and NGT groups, omentin-1 levels remained negatively correlated with BMI, 2 h postprandial C-peptide, and circulating androgens and demonstrated a negative linear trend according to quartile of free testosterone (P=0.028).
  
  
  CONCLUSIONS
  Plasma levels of omentin-1 were reduced in non-obese women with PCOS and NGT. Postprandial hyperinsulinemia and hyperglycemia contributed more to lower omentin-1 levels than did fasting values in the setting of PCOS. Increased androgen levels contributed to decreased omentin-1 levels in women with PCOS.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 110-746, Korea.
authors.forename: Ji-Hun
authors.initials: JH
authors.lastname: Choi
authors.forename: Eun-Jung
authors.initials: EJ
authors.lastname: Rhee
authors.forename: Kye-Hyun
authors.initials: KH
authors.lastname: Kim
authors.forename: Hee-Yeon
authors.initials: HY
authors.lastname: Woo
authors.forename: Won-Young
authors.initials: WY
authors.lastname: Lee
authors.forename: Ki-Chul
authors.initials: KC
authors.lastname: Sung
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000097:blood*; D015536:Down-Regulation / Q000502:physiology*; D005260:Female; D058851:GPI-Linked Proteins / Q000037:antagonists & inhibitors / Q000097:blood; D005951:Glucose Tolerance Test / Q000379:methods; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D037102:Lectins / Q000037:antagonists & inhibitors / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000175:diagnosis*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins