title: Clinical characteristics of nosocomial infections of patients with acute central nervous system infections treated in ICU.
abstract: A retrospective study was performed to evaluate the clinical characteristics of nosocomial infections in patients with acute infection of central nervous system (ACNS infections). The study included 1,686 patients admitted to the ICU. Of 1,686 patients, 936 (55.5%) had ACNS infection. Nosocomial infections was confirmed in 221 (23.6%) patients with ACNS infection. The most common risk factors for ICU-acquired nosocomial infections were consciousness disorder, mechanical ventilation and nasogastric tube. The coagulase - negative Staphylococcus aureus was the most frequent isolated pathogen (285 isolates, 56.5%). Results suggest that a persistently high level of therapeutic activity and persistently depressed consciousness after the ICU admission are associated with the occurrence of hospital-acquired infection in critically ill patients hospitalized at a medical ICU.
authors.affiliation: Department for Infectious Diseases, Clinical Center of Kragujevac, Kragujevac, Serbia. gaja.kg@open.telekom.rs
authors.forename: Olgica
authors.initials: O
authors.lastname: Gajović
authors.forename: Miroslav
authors.initials: M
authors.lastname: Tomović
authors.forename: Jelena
authors.initials: J
authors.lastname: Stanarcić
authors.forename: Predrag
authors.initials: P
authors.lastname: Canović
authors.forename: Zoran
authors.initials: Z
authors.lastname: Todorović
authors.forename: Zorica
authors.initials: Z
authors.lastname: Lazić
mesh_terms: D000208:Acute Disease; D000328:Adult; D002494:Central Nervous System Infections / Q000150:complications / Q000628:therapy*; D003428:Cross Infection / Q000175:diagnosis* / Q000209:etiology / Q000382:microbiology; D006801:Humans; D007362:Intensive Care Units; D008875:Middle Aged