title: [Peptides derived from the extracellular loop of receptors: structure, mechanisms of action and application in physiology and medicine].
abstract: One of the main tasks of the peptide strategy, a new direction in modern biochemistry and physiology, is the creation of selective and effective regulators of hormonal signaling systems on the basis of the peptides corresponding to functionally important regions of signal proteins. At the last years the greatest interest is connected with peptides, derivatives of the extracellular loops of receptors of the serpentine type. With these peptides the molecular basis of interaction between receptors and their ligands are studied, the new approaches for construction and testing of highly selective agonists and antagonists are developed, the etiology and pathogenesis of diseases of human and animals induced by autoimmune reactions to the extracellular loops of receptors are investigated. It is shown that peptides corresponding to the extracellular loops of the receptors and the specific antibodies to them are capable to regulate the activity of hormonal signaling systems in vitro and in vivo and can be considered as functional probes for studying of physiological functions in the norm and pathology. In the review the data obtained during the last years concerning the structures, functions, mechanisms of action and practical application ofpeptides, derivatives of the extracellular loops of serpentine type receptors, are summarized and analyzed. The prospective of their use in fundamental biology and practical medicine are discussed.
authors.forename: A O
authors.initials: AO
authors.lastname: Shpakov
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000906:Antibodies / Q000737:chemistry / Q000276:immunology* / Q000627:therapeutic use; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000628:therapy; D019077:Helix-Turn-Helix Motifs; D006464:Hemoperfusion / Q000379:methods; D057166:High-Throughput Screening Assays; D006728:Hormones / Q000502:physiology; D006801:Humans; D008024:Ligands; D018716:Molecular Mimicry / Q000276:immunology; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis / Q000276:immunology / Q000627:therapeutic use; D017434:Protein Structure, Tertiary; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology
chemical_list: D000906:Antibodies; D000998:Antiviral Agents; D006728:Hormones; D008024:Ligands; D010455:Peptides; D011956:Receptors, Cell Surface