title: Practice bulletin no. 124: inherited thrombophilias in pregnancy.
abstract: Inherited thrombophilias are associated with an increased risk of venous thromboembolism and also have been linked to adverse outcomes in pregnancy. However, there is limited evidence to guide screening for and management of these conditions in pregnancy. The purpose of this document is to review common thrombophilias and their association with maternal venous thromboembolism risk and adverse pregnancy outcomes, indications for screening to detect these conditions, and management options in pregnancy.
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage; D005165:Factor V / Q000235:genetics; D005260:Female; D005313:Fetal Death / Q000453:epidemiology; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D020138:Hyperhomocysteinemia / Q000453:epidemiology / Q000235:genetics; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D018579:Patient Selection; D017354:Point Mutation; D011225:Pre-Eclampsia / Q000453:epidemiology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis / Q000628:therapy*; D011256:Pregnancy Outcome; D020151:Protein C Deficiency / Q000175:diagnosis / Q000453:epidemiology; D018455:Protein S Deficiency / Q000175:diagnosis / Q000453:epidemiology; D011516:Prothrombin / Q000235:genetics; D018570:Risk Assessment; D012307:Risk Factors; D019851:Thrombophilia / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D054556:Venous Thromboembolism / Q000453:epidemiology / Q000209:etiology / Q000235:genetics / Q000517:prevention & control
chemical_list: D000925:Anticoagulants; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; D042965:Methylenetetrahydrofolate Reductase (NADPH2)