title: Efficacy of Leuprolide Acetate 1-Month Depot for Central Precocious Puberty (CPP): Growth Outcomes During a Prospective, Longitudinal Study.
abstract: BACKGROUND
  Gonadotropin-releasing hormone analogs (GnRHa) are the treatment of choice for CPP. We investigated growth in GnRHa-naïve subjects, treated with leuprolide acetate 1-month depot for CPP.
  
  
  METHODS
  This prospective, open-label study had a long-term, observational, follow-up period. Forty-nine females and 6 males were enrolled. Leuprolide acetate depot was administered intramuscularly every 28 days. Height and growth rate during and after treatment until adulthood were measured.
  
  
  RESULTS
  Among 30 of 49 females having an adult height (AH) measurement, 29 had target heights available (mean = 163.8 cm) and 27 had pretreatment predicted adult heights (PAHs; mean = 157.4 cm). After treatment, the mean AH at mean age 21.8 years [range 13.7-26.7 years] was 162.5 cm, a mean height gain over baseline PAH of 4.0 cm. The mean height standard deviation score was -0.1 at AH.
  
  
  CONCLUSIONS
  Treatment of CPP with leuprolide acetate 1-month depot had beneficial effects on growth rate and preservation of AH.
  
  
  BACKGROUND
  ClinicalTrials.gov: NCT00660010.
authors.affiliation: The Milton S. Hershey Medical Center, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Lee
authors.forename: E Kirk
authors.initials: EK
authors.lastname: Neely
authors.forename: John
authors.initials: J
authors.lastname: Fuqua
authors.forename: Di
authors.initials: D
authors.lastname: Yang
authors.forename: Lois M
authors.initials: LM
authors.lastname: Larsen
authors.forename: Cynthia
authors.initials: C
authors.lastname: Mattia-Goldberg
authors.forename: Kristof
authors.initials: K
authors.lastname: Chwalisz