title: COMT haplotype analyses in Malaysians with schizophrenia.
abstract: The present study included a total 261 patients with schizophrenia and 261 healthy controls to replicate the genetic association between the cathechol-o-methyltransferase gene and schizophrenia using a haplotype block-based gene-tagging. The G-G-G haplotype was found to show a highly significant association with schizophrenia.
authors.affiliation: Department of Chemical Engineering, Faculty of Engineering and Science, Universiti Tunku Abdul Rahman, Jalan Genting Kelang, Setapak, 53300 Kuala Lumpur, Malaysia.
authors.forename: Shiau Foon
authors.initials: SF
authors.lastname: Tee
authors.forename: Pek Yee
authors.initials: PY
authors.lastname: Tang
authors.forename: Han Chern
authors.initials: HC
authors.lastname: Loh
mesh_terms: D000293:Adolescent; D000328:Adult; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008296:Malaysia / Q000208:ethnology; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*; D055815:Young Adult
chemical_list: D002394:Catechol O-Methyltransferase