title: Control of gene transcription by Mediator in chromatin.
abstract: The Mediator complex serves as an adaptor for regulatory factors, recruits and controls RNA polymerase II promotes preinitiation complex formation and functions post initiation. There is increasing evidence for further coordinating roles of the Mediator complex in chromatin. Here we summarize interactions with regulatory, general and accessory factors that function in transcription and chromatin.
authors.affiliation: Institute of Molecular Tumor Biology, Westfalian Wilhelms University, Münster, Germany, Robert-Koch Strasse 43, 48149 Münster, Germany.
authors.forename: David
authors.initials: D
authors.lastname: Ries
authors.forename: Michael
authors.initials: M
authors.lastname: Meisterernst
mesh_terms: D000818:Animals; D002843:Chromatin / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D056892:Mediator Complex / Q000378:metabolism*; D012319:RNA Polymerase II / Q000235:genetics / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic; D015003:Yeasts / Q000235:genetics / Q000378:metabolism
chemical_list: D002843:Chromatin; D056892:Mediator Complex; D016601:RNA-Binding Proteins; D014157:Transcription Factors; D012319:RNA Polymerase II