title: Allergic rhinitis and asthma: celebrating 100 years of immunotherapy.
abstract: Since Noon first described allergen immunotherapy a century ago the basic premise of subcutaneous injections (SCIT) of relevant aeroallergens to induce clinical tolerance has remained true [1]. Indeed, allergen immunotherapy did not change dramatically over the first 75 years, but over the past 25 years there have been a number of important advancements leading to newer approaches and novel formulations. Here we review the top 50 articles published in the past 2 years on allergens, environmental control, and immunotherapy for asthma and allergic rhinitis and the use of immunomodulators in allergic disease.
authors.affiliation: Creighton University School Medicine, Department of Medicine, Allergy/Immunology Division, Omaha, NE 68131, United States.
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Stokes
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Casale
mesh_terms: D000485:Allergens / Q000276:immunology; D000888:Antibodies, Anti-Idiotypic / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology / Q000628:therapy*; D007167:Immunotherapy / Q000009:adverse effects; D000069444:Omalizumab; D012220:Rhinitis / Q000276:immunology / Q000628:therapy*
chemical_list: D000485:Allergens; D000888:Antibodies, Anti-Idiotypic; D061067:Antibodies, Monoclonal, Humanized; D000069444:Omalizumab