title: [Organ specificity of the genotoxic effects of cyclophosphane and dioxidine: an alkaline comet assay study].
abstract: The applicability of alkaline comet assay to studying the organ specificity of the genotoxic effects of drugs has been estimated using cells from four organs of mice (the liver, lungs, spleen, and brain). It has been found that cyclophosphamide damages DNA in all the four organs; and dioxidine, in all organs except the brain. It is concluded that this method can be used for studying the organ specificity of the DNA-damaging effects of various substances.
authors.forename: K G
authors.initials: KG
authors.lastname: Ordzhonikidze
authors.forename: A M
authors.initials: AM
authors.lastname: Zanadvorova
authors.forename: S K
authors.initials: SK
authors.lastname: Abilev
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000494:pharmacology; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects* / Q000494:pharmacology; D020552:Comet Assay; D003520:Cyclophosphamide / Q000009:adverse effects* / Q000494:pharmacology; D004249:DNA Damage / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009928:Organ Specificity; D011810:Quinoxalines / Q000009:adverse effects* / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D018906:Antineoplastic Agents, Alkylating; D011810:Quinoxalines; C001077:dioxidine; D003520:Cyclophosphamide