title: Does human bocavirus infection depend on helper viruses? A challenging case report.
abstract: A case of severe diarrhoea associated with synergistic human bocavirus type 1 (HBoV) and human herpes virus type 6 (HHV6) is reported. The case supports the hypotheses that HBoV infection under clinical conditions may depend on helper viruses, or that HBoV replicates by a mechanism that is atypical for parvoviruses, or that HBoV infection can be specifically treated with cidofovir.
authors.affiliation: Klinik für Kinder- und Jugendmedizin, Kinderkrankenhaus, Kliniken der Stadt Köln gGmbH, Amsterdamer Str. 59, Cologne 50735, Germany.
authors.forename: Monika
authors.initials: M
authors.lastname: Streiter
authors.forename: Monika
authors.initials: M
authors.lastname: Malecki
authors.forename: Aram
authors.initials: A
authors.lastname: Prokop
authors.forename: Verena
authors.initials: V
authors.lastname: Schildgen
authors.forename: Jessica
authors.initials: J
authors.lastname: Lüsebrink
authors.forename: Andreas
authors.initials: A
authors.lastname: Guggemos
authors.forename: Matthias
authors.initials: M
authors.lastname: Wisskirchen
authors.forename: Michael
authors.initials: M
authors.lastname: Weiss
authors.forename: Reinhold
authors.initials: R
authors.lastname: Cremer
authors.forename: Michael
authors.initials: M
authors.lastname: Brockmann
authors.forename: Oliver
authors.initials: O
authors.lastname: Schildgen
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000077404:Cidofovir; D060085:Coinfection / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000821:virology*; D003596:Cytosine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004279:DNA, Viral / Q000032:analysis; D003967:Diarrhea / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000821:virology*; D006378:Helper Viruses / Q000187:drug effects / Q000502:physiology*; D015654:Herpesvirus 6, Human / Q000187:drug effects / Q000502:physiology*; D056661:Human bocavirus / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007223:Infant; D008297:Male; D063065:Organophosphonates / Q000008:administration & dosage / Q000627:therapeutic use*; D010322:Parvoviridae Infections / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000821:virology*; D016133:Polymerase Chain Reaction; D019349:Roseolovirus Infections / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000821:virology*; D019562:Viral Load / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir