title: La Crosse encephalitis surveillance using single versus paired serologic testing.
abstract: We evaluated the validity of single versus paired serologic testing for La Crosse virus (LACV) encephalitis surveillance. Compared with paired serology, a single positive IgG or IgM immunoflourescent antibody titre appears useful for LACV encephalitis surveillance with sensitivity, 75%; specificity, 98%; positive predictive value, 95%; and overall test efficiency 92%.
authors.affiliation: Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, USA. zle9@cdc.gov
authors.forename: R
authors.initials: R
authors.lastname: Murphree
authors.forename: J R
authors.initials: JR
authors.lastname: Dunn
authors.forename: W
authors.initials: W
authors.lastname: Schaffner
authors.forename: T F
authors.initials: TF
authors.lastname: Jones
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis / Q000276:immunology; D000956:Antigens, Viral / Q000032:analysis / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004670:Encephalitis, California / Q000175:diagnosis* / Q000276:immunology / Q000821:virology; D005260:Female; D005455:Fluorescent Antibody Technique; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D007223:Infant; D018062:La Crosse virus / Q000276:immunology* / Q000302:isolation & purification; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D018571:Sentinel Surveillance; D012698:Serologic Tests / Q000379:methods*; D013714:Tennessee / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M