title: Significant inverse associations of serum n-6 fatty acids with plasma plasminogen activator inhibitor-1.
abstract: Epidemiological studies suggested that n-6 fatty acids, especially linoleic acid (LA), have beneficial effects on CHD, whereas some in vitro studies have suggested that n-6 fatty acids, specifically arachidonic acid (AA), may have harmful effects. We examined the association of serum n-6 fatty acids with plasminogen activator inhibitor-1 (PAI-1). A population-based cross-sectional study recruited 926 randomly selected men aged 40-49 years without CVD during 2002-2006 (310 Caucasian, 313 Japanese and 303 Japanese-American men). Plasma PAI-1 was analysed in free form, both active and latent. Serum fatty acids were measured with gas-capillary liquid chromatography. To examine the association between total n-6 fatty acids (including LA and AA) and PAI-1, multivariate regression models were used. After adjusting for confounders, total n-6 fatty acids, LA and AA, were inversely and significantly associated with PAI-1 levels. These associations were consistent across three populations. Among 915 middle-aged men, serum n-6 fatty acids had significant inverse associations with PAI-1.
authors.affiliation: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA.
authors.forename: Sunghee
authors.initials: S
authors.lastname: Lee
authors.forename: J David
authors.initials: JD
authors.lastname: Curb
authors.forename: Takashi
authors.initials: T
authors.lastname: Kadowaki
authors.forename: Rhobert W
authors.initials: RW
authors.lastname: Evans
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Miura
authors.forename: Tomoko
authors.initials: T
authors.lastname: Takamiya
authors.forename: Chol
authors.initials: C
authors.lastname: Shin
authors.forename: Aiman
authors.initials: A
authors.lastname: El-Saed
authors.forename: Jina
authors.initials: J
authors.lastname: Choo
authors.forename: Akira
authors.initials: A
authors.lastname: Fujiyoshi
authors.forename: Teruo
authors.initials: T
authors.lastname: Otake
authors.forename: Sayaka
authors.initials: S
authors.lastname: Kadowaki
authors.forename: Todd
authors.initials: T
authors.lastname: Seto
authors.forename: Kamal
authors.initials: K
authors.lastname: Masaki
authors.forename: Daniel
authors.initials: D
authors.lastname: Edmundowicz
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Ueshima
authors.forename: Lewis H
authors.initials: LH
authors.lastname: Kuller
authors.forename: Akira
authors.initials: A
authors.lastname: Sekikawa
mesh_terms: D000328:Adult; D016718:Arachidonic Acid / Q000097:blood; D001213:Asian; D044466:Asian People; D015992:Body Mass Index; D015331:Cohort Studies; D003327:Coronary Disease / Q000097:blood / Q000453:epidemiology* / Q000208:ethnology; D003430:Cross-Sectional Studies; D043371:Fatty Acids, Omega-6 / Q000008:administration & dosage / Q000097:blood*; D006254:Hawaii / Q000453:epidemiology; D006801:Humans; D007564:Japan / Q000453:epidemiology / Q000208:ethnology; D019787:Linoleic Acid / Q000097:blood; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D010414:Pennsylvania / Q000453:epidemiology; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D012307:Risk Factors; D044465:White People
chemical_list: D043371:Fatty Acids, Omega-6; D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human; D016718:Arachidonic Acid; D019787:Linoleic Acid