title: In vitro antibacterial activities of doripenem, imipenem, and meropenem against recent Streptococcus pneumoniae isolates.
abstract: We investigated the in vitro activities of carbapenems against 347 Streptococcus pneumoniae isolates from Korea. While doripenem and imipenem resistance was displayed by only 1.2% and 3.2%, respectively, 21.3% of the isolates were resistant to meropenem. One isolate displaying very high carbapenem MICs and susceptibility only to vancomycin was also identified.
authors.affiliation: Asia Pacific Foundation for Infectious Diseases (APFID), Seoul 135-710, Korea.
authors.forename: Jin Yang
authors.initials: JY
authors.lastname: Baek
authors.forename: Kwan Soo
authors.initials: KS
authors.lastname: Ko
authors.forename: Cheol-In
authors.initials: CI
authors.lastname: Kang
authors.forename: Jae-Hoon
authors.initials: JH
authors.lastname: Song
authors.forename: Kyong Ran
authors.initials: KR
authors.lastname: Peck
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015780:Carbapenems / Q000494:pharmacology*; D000077726:Doripenem; D024881:Drug Resistance, Bacterial / Q000235:genetics; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D013845:Thienamycins / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D013845:Thienamycins; D015378:Imipenem; D000077726:Doripenem; D000077731:Meropenem