title: Sleep deprivation reduces default mode network connectivity and anti-correlation during rest and task performance.
abstract: Sleep deprivation (SD) can alter extrinsic, task-related fMRI signal involved in attention, memory and executive function. However, its effects on intrinsic low-frequency connectivity within the Default Mode Network (DMN) and its related anti-correlated network (ACN) have not been well characterized. We investigated the effect of SD on functional connectivity within the DMN, and on DMN-ACN anti-correlation, both during the resting state and during performance of a visual attention task (VAT). 26 healthy participants underwent fMRI twice: once after a normal night of sleep in rested wakefulness (RW) and once following approximately 24h of total SD. A seed-based approach was used to examine pairwise correlations of low-frequency fMRI signal across different nodes in each state. SD was associated with significant selective reductions in DMN functional connectivity and DMN-ACN anti-correlation. This was congruent across resting state and VAT analyses, suggesting that SD induces a robust alteration in the intrinsic connectivity within and between these networks.
authors.affiliation: Cognitive Neuroscience Laboratory, Duke-NUS Graduate Medical School, Singapore.
authors.forename: Jack A
authors.initials: JA
authors.lastname: De Havas
authors.forename: Sarayu
authors.initials: S
authors.lastname: Parimal
authors.forename: Chun Siong
authors.initials: CS
authors.lastname: Soon
authors.forename: Michael W L
authors.initials: MW
authors.lastname: Chee
mesh_terms: D001288:Attention; D001921:Brain / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000503:physiopathology*; D012146:Rest / Q000502:physiology*; D012892:Sleep Deprivation / Q000503:physiopathology*; D013223:Statistics as Topic; D013647:Task Performance and Analysis; D014796:Visual Perception; D055815:Young Adult