title: Meeting report: American Aging Association 40th Annual Meeting, Raleigh, North Carolina, June 3-6, 2011.
abstract: The focus of the 2011 American Aging Association meeting was emerging concepts in the mechanisms of aging. Many of the usual topics in aging were covered, such as dietary restriction (DR), inflammation, stress resistance, homeostasis and proteasome activity, sarcopenia, and neural degeneration. There was also discussion of newer methods, such as microRNAs and genome sequencing, that have been employed to investigate gene expression variance with aging and genetic signatures of longevity. Aging as a field continues to mature, including the following areas: Using a systems approach to tracing conserved pathways across organisms; sharpening definitions of sarcopenia, frailty, and health span; and distinguishing interventions by age tier (early-onset versus late-onset). A preconference session on late-onset intervention concluded that there are numerous benefits to deriving such interventions. Conference talks applied the biology of aging in a translational manner to intervention development. Using an individual's own stem cells to regenerate organs for transplantation and as a cell source for cellular therapies could be a powerful near-term solution to disease. Several proposed interventions were pharmaceutical, myostatin inhibition, losartan, Janus kinase (JAK) pathway inhibitors, and enalapril for frailty and sarcopenia, and metformin to promote the Nrf2 antiinflammation response. In DR, protein restriction was found to be better than general calorie restriction. Short-term fasting may be helpful in chemotherapy, surgery, and acute stress, simultaneously increasing the killing of cancer cells by chemotherapy, while improving the survival of normal cells. Immune system interventions remain elusive, although statins may help to improve cellular senescence promoted bacterial infection. Engineered enzymes may be useful in lysosomal catabolism. Dietary restriction mimetics, most promisingly involving target of rapamycin (TOR; TORC1 inhibition and rapamycin), may be more feasible than dietary restriction.
authors.affiliation: MS Futures Group, Palo Alto, CA 94306, USA. m@melanieswan.com
authors.forename: Melanie
authors.initials: M
authors.lastname: Swan
mesh_terms: D000375:Aging / Q000187:drug effects / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D000596:Amino Acids / Q000172:deficiency; D000818:Animals; D031204:Caloric Restriction; D004703:Endocrine System / Q000187:drug effects / Q000378:metabolism; D005215:Fasting; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism; D019577:Mole Rats; D009657:North Carolina; D018384:Oxidative Stress / Q000187:drug effects; D057285:Precision Medicine; D020123:Sirolimus / Q000494:pharmacology; D012955:Societies, Medical; D013234:Stem Cells / Q000187:drug effects / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D057170:Translational Research, Biomedical
chemical_list: D000596:Amino Acids; D035683:MicroRNAs; D014157:Transcription Factors; D020123:Sirolimus