title: [Peculiarities of the ovary structure in the rat offspring developing under conditions of the removed thyroid gland of female rat with the thyroxine replacement therapy and external radiation exposure in utero].
abstract: The influence of a single external gamma-radiation at a dose of 1.0 Gy (dose rate 9.08 x 10(-4) Gy/sec) on the 15th day of gestation in case of the removed complex of thyroid and parathyroid glands (thyroidparathyroidectomy) on the first day of gestation, as well as introduction of thyroxin and CaC12 on the structure of offspring ovary in postnatal ontogenesis (30-day old animals) was studied. It has been shown that thyroidparathyroidectomy of a female mother rat with thyroxine replacement therapy and irradiation, as well as the combination of these factors disturb the structure of ovarian tissues of the offspring. A single external irradiation on the 15th day of embryogenesis causes death of a considerable part of primordial follicles in the offspring ovary and growth of follicular layers in the secondary follicles. Thyroidparathyroidectomy of female rat on the first day of gestation with thyroxine replacement therapy causes delay in the development of follicles in the ovary at the early stages of maturation of 30-day old animals. The radiosensitivity of the ovarian tissues of the offspring that has been developed under the combined effect of the factors studied increases and results in an almost full loss of pool cells in the ovary of infant rats.
authors.forename: E F
authors.initials: EF
authors.lastname: Konoplia
authors.forename: V S
authors.initials: VS
authors.lastname: Pavlenko
authors.forename: N V
authors.initials: NV
authors.lastname: Banetskaia
authors.forename: I I
authors.initials: II
authors.lastname: Krylova
mesh_terms: D000818:Animals; D005260:Female; D005720:Gamma Rays / Q000009:adverse effects*; D005865:Gestational Age; D020249:Hormone Replacement Therapy; D010053:Ovary / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced / Q000209:etiology / Q000473:pathology*; D051381:Rats; D013961:Thyroid Gland / Q000378:metabolism*; D013965:Thyroidectomy; D013974:Thyroxine / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use
chemical_list: D013974:Thyroxine