title: Tubular nephrotoxicity induced by docetaxel in non-small-cell lung cancer patients.
abstract: Renal dysfunction is a characteristic of many patients with cancer; however, a standard therapy has not been established for stage III or IV non-small-cell lung cancer (NSCLC) complicated with chronic renal failure. Docetaxel has a proven significant activity against NSCLC. This agent is predominantly eliminated by hepatobiliary extraction and is safe in patients with renal failure, including dialysis patients. Docetaxel is, thus, a therapeutic option in that patient population. Here, we report acute tubular nephrotoxicity secondary to docetaxel in NSCLC patients, even in patients with normal renal function. Little is known about tubular nephrotoxicity induced by docetaxel; however, oncologists should be aware of its possibility.
authors.affiliation: Department of Internal Medicine, Toyonaka Municipal Hospital, 4-14-1 Shibahara-cho, Toyonaka, Osaka, 560-8565, Japan. taka2003@chp.toyonaka.osaka.jp
authors.forename: Takayuki
authors.initials: T
authors.lastname: Takimoto
authors.forename: Tasuku
authors.initials: T
authors.lastname: Nakabori
authors.forename: Akio
authors.initials: A
authors.lastname: Osa
authors.forename: Satomu
authors.initials: S
authors.lastname: Morita
authors.forename: Haruko
authors.initials: H
authors.lastname: Terada
authors.forename: Susumu
authors.initials: S
authors.lastname: Oseto
authors.forename: Takashi
authors.initials: T
authors.lastname: Iwazawa
authors.forename: Kinya
authors.initials: K
authors.lastname: Abe
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000473:pathology; D000077143:Docetaxel; D005260:Female; D006801:Humans; D007684:Kidney Tubules / Q000187:drug effects / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D051437:Renal Insufficiency / Q000139:chemically induced* / Q000473:pathology; D043823:Taxoids / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D043823:Taxoids; D000077143:Docetaxel