title: Cancer mortality among aircraft manufacturing workers: an extended follow-up.
abstract: OBJECTIVE
  Extended cancer follow-up among 77,943 aircraft workers.
  
  
  METHODS
  Comprehensive exposure information enabled detailed classification of trichloroethylene (TCE), perchloroethylene (PCE), mixed solvents, and chromates exposure among these workers.
  
  
  RESULTS
  Exposure to TCE, PCE, mixed solvents or chromates was not associated with increased cancer risk overall or for most cancer sites. Elevated rates compared with the general population were seen for non-Hodgkin lymphoma for PCE exposure, and colon and testicular cancers and multiple myeloma for mixed solvents exposure. Internal cohort analyses, however, showed no significant trends of increasing risk for these cancers with increasing years of exposure to TCE, PCE or mixed solvents.
  
  
  CONCLUSIONS
  This large, long-term cohort study with comprehensive exposure assessment found no consistent evidence of increased cancer risk overall or by site among aircraft workers, including those with long-term exposure to TCE, PCE, and mixed solvents.
authors.affiliation: International Epidemiology Institute, Rockville, MD 20850, USA. loren@iei.us
authors.forename: Loren
authors.initials: L
authors.lastname: Lipworth
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Sonderman
authors.forename: Michael T
authors.initials: MT
authors.lastname: Mumma
authors.forename: Robert E
authors.initials: RE
authors.lastname: Tarone
authors.forename: Donald E
authors.initials: DE
authors.lastname: Marano
authors.forename: John D
authors.initials: JD
authors.lastname: Boice
authors.forename: Joseph K
authors.initials: JK
authors.lastname: McLaughlin
mesh_terms: D000401:Aircraft / Q000706:statistics & numerical data*; D002140:California / Q000453:epidemiology; D002840:Chromates / Q000009:adverse effects; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000139:chemically induced / Q000401:mortality*; D009784:Occupational Diseases / Q000139:chemically induced / Q000401:mortality*; D016273:Occupational Exposure / Q000009:adverse effects*; D012997:Solvents / Q000009:adverse effects; D013750:Tetrachloroethylene / Q000009:adverse effects; D014241:Trichloroethylene / Q000009:adverse effects
chemical_list: D002840:Chromates; D012997:Solvents; D014241:Trichloroethylene; D013750:Tetrachloroethylene