title: Relationship between vision-related quality of life and microperimetry-determined macular sensitivity in patients with retinitis pigmentosa.
abstract: OBJECTIVE
  The aim of our study was to determine the relationship between vision-related quality of life (VRQOL) following the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25) and the macular sensitivity determined by microperimetry in patients with retinitis pigmentosa (RP).
  
  
  METHODS
  The Japanese version of the NEI VFQ-25 was used to assess the VRQOL of 30 patients with typical RP whose decimal visual acuity was ≥0.6. The mean retinal sensitivity within the central 10° was determined by fundus-related microperimetry (MP1). The correlation between the mean of the total composite NEI VFQ-25 score and MP1-determined macular sensitivity was determined.
  
  
  RESULTS
  Mean NEI VFQ-25 score was 69.4 ± 14.5 (range 34.6-90.3) in RP patients. There was a significant positive correlation between mean NEI VFQ-25 score and mean retinal sensitivity within 10° (r = 0.673, P = 0.0003).
  
  
  CONCLUSIONS
  The significant correlation between macular sensitivity and VRQOL measured with the NEI VFQ-25 indicates that sensitivity in the macular area is an important consideration in using VRQOL with RP patients.
authors.affiliation: Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. takeshis@faculty.chiba-u.jp
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sugawara
authors.forename: Eiju
authors.initials: E
authors.lastname: Sato
authors.forename: Takayuki
authors.initials: T
authors.lastname: Baba
authors.forename: Akira
authors.initials: A
authors.lastname: Hagiwara
authors.forename: Ayako
authors.initials: A
authors.lastname: Tawada
authors.forename: Shuichi
authors.initials: S
authors.lastname: Yamamoto
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012160:Retina / Q000503:physiopathology*; D012174:Retinitis Pigmentosa / Q000503:physiopathology*; D018434:Sickness Impact Profile; D011795:Surveys and Questionnaires; D014786:Vision Disorders / Q000503:physiopathology*; D014785:Vision, Ocular / Q000502:physiology*; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology*; D055815:Young Adult