title: Multiple aspects of the interaction of biomacromolecules with inorganic surfaces.
abstract: The understanding of the mechanisms involved in the interaction of biological systems with inorganic materials is of interest in both fundamental and applied disciplines. The adsorption of proteins modulates the formation of biofilms onto surfaces, a process important in infections associated to medical implants, in dental caries, in environmental technologies. The interaction with biomacromolecules is crucial to determine the beneficial/adverse response of cells to foreign inorganic materials as implants, engineered or accidentally produced inorganic nanoparticles. A detailed knowledge of the surface/biological fluids interface processes is needed for the design of new biocompatible materials. Researchers involved in the different disciplines face up with similar difficulties in describing and predicting phenomena occurring at the interface between solid phases and biological fluids. This review represents an attempt to integrate the knowledge from different research areas by focussing on the search for determinants driving the interaction of inorganic surfaces with biological matter.
authors.affiliation: Dipartimento di Chimica Inorganica, Chimica Fisica e Chimica dei Materiali, University of Torino, via Pietro Giuria 7, 10125 Torino, Italy. ivana.fenoglio@unito.it
authors.forename: Ivana
authors.initials: I
authors.lastname: Fenoglio
authors.forename: Bice
authors.initials: B
authors.lastname: Fubini
authors.forename: Elena M
authors.initials: EM
authors.lastname: Ghibaudi
authors.forename: Francesco
authors.initials: F
authors.lastname: Turci
mesh_terms: D000327:Adsorption; D001672:Biocompatible Materials / Q000737:chemistry*; D018441:Biofilms; D001826:Body Fluids / Q000378:metabolism; D006801:Humans; D046911:Macromolecular Substances / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry; D019736:Prostheses and Implants; D011506:Proteins / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D046911:Macromolecular Substances; D011506:Proteins