title: Human dendritic cell deficiency: the missing ID?
abstract: Animal models and human in vitro systems indicate that dendritic cells (DCs) have a crucial role in priming naive T cells, but just how important are they in the intact human? Recent descriptions of human DC deficiency have begun to shed light on this question and to illuminate other puzzles of human DC biology, including their haematopoietic origin, developmental regulation and homeostatic equilibrium with other leukocytes. In this Review, we explore the recently described DC deficiency syndromes, discussing what these have taught us with regard to DC function in humans and the important issues that remain unsolved.
authors.affiliation: Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK. matthew.collin@ncl.ac.uk
authors.forename: Matthew
authors.initials: M
authors.lastname: Collin
authors.forename: Venetia
authors.initials: V
authors.lastname: Bigley
authors.forename: Muzlifah
authors.initials: M
authors.lastname: Haniffa
authors.forename: Sophie
authors.initials: S
authors.lastname: Hambleton
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism*; D050989:GATA2 Transcription Factor / Q000235:genetics; D006801:Humans; D007153:Immunologic Deficiency Syndromes; D050835:Interferon Regulatory Factors / Q000235:genetics; D051379:Mice; D009154:Mutation; D013601:T-Lymphocytes; D000099185:Interferon Regulatory Factor-8
chemical_list: D050989:GATA2 Transcription Factor; D050835:Interferon Regulatory Factors; D000099185:Interferon Regulatory Factor-8