title: Therapeutic lifestyle modification program reduces plasma levels of the chemokines CRP and MCP-1 in subjects with metabolic syndrome.
abstract: OBJECTIVE
  The purpose of this study was to examine the effects of a 6-month therapeutic lifestyle modification (TLM) program on chemokines related to oxidative stress, inflammation, endothelial dysfunction, and arterial stiffness in subjects with metabolic syndrome (MetS).
  
  
  METHODS
  The authors performed a randomized controlled trial, assigning 52 women (mean age 62.7 ± 9.0 years) with MetS to a TLM intervention group (n = 31) or a control group (n = 21). The authors provided the TLM intervention group with health screening, exercise, low-calorie diet, and health education and counseling for 6 months and instructed the control group to maintain their usual lifestyle behaviors. Outcome variables included levels of myeloperoxidase (MPO), oxidized low-density lipoprotein (LDL), adiponectin, leptin, resistin, high-sensitivity C-reactive protein (hs-CRP), interleukin-1β, interleukin-6, tumor necrosis factor-alpha (TNF-α), CD40L, monocyte chemotactic protein-1 (MCP-1), retinol-binding protein 4 (RBP-4), endothelin-1, and brachial-ankle pulse wave velocity. The authors used generalized estimating equation (GEE) analyses to estimate the effects of the TLM program.
  
  
  RESULTS
  After the 6-month TLM program, hs-CRP levels decreased significantly, and MCP-1 levels increased at a significantly slower rate in the TLM group than they did in the control group (all p < .05).
  
  
  CONCLUSIONS
  These results indicate that a TLM program could be effective for improving patient inflammatory states and may also be effective in preventing cardiovascular complications in subjects with MetS.
authors.affiliation: College of Nursing, Nursing Policy and Research Institution, Yonsei University, Seoul, Korea. euigeum@yuhs.ac
authors.forename: Eui Geum
authors.initials: EG
authors.lastname: Oh
authors.forename: So Youn
authors.initials: SY
authors.lastname: Bang
authors.forename: Soo Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Sa Saeng
authors.initials: SS
authors.lastname: Hyun
authors.forename: Sang Hui
authors.initials: SH
authors.lastname: Chu
authors.forename: Justin Y
authors.initials: JY
authors.lastname: Jeon
authors.forename: Jee Aee
authors.initials: JA
authors.lastname: Im
authors.forename: Jung Eun
authors.initials: JE
authors.lastname: Lee
authors.forename: Mi Kyung
authors.initials: MK
authors.lastname: Lee
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000097:blood*; D004032:Diet; D015444:Exercise; D005260:Female; D006266:Health Education; D006801:Humans; D008019:Life Style; D024821:Metabolic Syndrome / Q000097:blood / Q000628:therapy*; D008875:Middle Aged; D018384:Oxidative Stress
chemical_list: D018932:Chemokine CCL2; D002097:C-Reactive Protein