title: Synthesis and characterization of novel PUFA esters exhibiting potential anticancer activities: an in vitro study.
abstract: Polyunsaturated fatty acids (PUFAs) have been reported to play a regulatory role in tumour growth progression. In the present study, we have synthesized ester derivatives of two important PUFA viz., linoleic acid (LA) and arachidonic acid (AA) with propofol, a widely used general anaesthetic-sedative agent. The novel propofol ester analogues have been found to inhibit various cancer cell lines in a dose-dependent manner. Moreover, the compounds have been found to induce apoptotic cell death by enhancing the release of cytochrome c and expression of caspase-3. The data of the present study suggest that novel propofol-PUFA esters have strong potential to emerge as effective anticancer agents.
authors.affiliation: Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India.
authors.forename: Azmat Ali
authors.initials: AA
authors.lastname: Khan
authors.forename: Mahboob
authors.initials: M
authors.lastname: Alam
authors.forename: Saba
authors.initials: S
authors.lastname: Tufail
authors.forename: Jamal
authors.initials: J
authors.lastname: Mustafa
authors.forename: Mohammad
authors.initials: M
authors.lastname: Owais
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D016718:Arachidonic Acid / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D053148:Caspase 3 / Q000378:metabolism; D045744:Cell Line, Tumor; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D005231:Fatty Acids, Unsaturated / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D019787:Linoleic Acid / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D009369:Neoplasms / Q000188:drug therapy; D015742:Propofol / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D004952:Esters; D005231:Fatty Acids, Unsaturated; D006993:Hypnotics and Sedatives; D016718:Arachidonic Acid; D019787:Linoleic Acid; D053148:Caspase 3; D015742:Propofol