title: Transcriptional control of natural killer cell differentiation and function.
abstract: Gene expression can be modulated depending on physiological and developmental requirements. A multitude of regulatory genes, which are organized in interdependent networks, guide development and eventually generate specific phenotypes. Transcription factors (TF) are a key element in the regulatory cascade controlling cell fate and effector functions. In this review, we discuss recent data on the diversity of TF that determine natural killer (NK) cell fate and NK cell function.
authors.affiliation: Medical Research Council (MRC) Centre for Transplantation, Guy's Hospital, King's College London, 5th floor Tower Wing, London SE1 9RT, UK. alfonso.martin-fontecha@kcl.ac.uk
authors.forename: Alfonso
authors.initials: A
authors.lastname: Martín-Fontecha
authors.forename: Graham M
authors.initials: GM
authors.lastname: Lord
authors.forename: Hugh J M
authors.initials: HJ
authors.lastname: Brady
mesh_terms: D002454:Cell Differentiation; D002465:Cell Movement; D006801:Humans; D007694:Killer Cells, Natural / Q000166:cytology* / Q000276:immunology / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D014157:Transcription Factors