title: Association between schizophrenia and single nucleotide polymorphisms in lipoprotein lipase gene in a Han Chinese population.
abstract: OBJECTIVE
  Many studies have suggested that certain types of lipids such as phospholipids, fatty acids, and cholesterols are involved in the pathology of nervous system diseases. Lipoprotein lipase (LPL), as the key enzyme of triglyceride hydrolysis, is expressed in the brain regions functionally relevant to learning, memory, and other cognitive functions. In addition, both genome-wide linkage and association studies in schizophrenia have implicated the chromosome 8p22 region, in which the LPL gene is located. Therefore, LPL is an attractive candidate gene for schizophrenia and we tested this hypothesis in a case-control sample.
  
  
  METHODS
  In this study, we investigated allele and genotype frequencies distributions of nine single nucleotide polymorphisms (SNPs) within the LPL gene in Han Chinese patients with schizophrenia (n=319) and healthy controls (n=575).
  
  
  RESULTS
  Significant differences were detected between case and control groups in the frequencies of rs253 alleles [odds ratio (OR): 1.74; 95% confidence interval (CI): 1.43-2.11; P=3.21×10] and genotypes (OR: 3.08; 95%CI: 2.07-4.56; global P=7.88×10), respectively. Interestingly, this association was observed only in the male (P=5.87×10 for allele; P=1.79×10 for genotype) and not in the female samples (P>0.05). After correcting for multiple testing, the above association remains to be significant (Pc<1×10). These results suggest that rs253 C allele and CC genotype confer risk for schizophrenia in men.
  
  
  CONCLUSIONS
  Our study lends support to the potential role of lipid metabolism in schizophrenia and further investigations are warranted.
authors.affiliation: Laboratory of Disorder Genes and Pharmacogenomics Research Center, Institute of Life Sciences, Chongqing University of Medical Sciences, College of Pharmacy, Chongqing University of Medical Sciences, P.R. China.
authors.forename: Cui
authors.initials: C
authors.lastname: Xie
authors.forename: Zeng Chan
authors.initials: ZC
authors.lastname: Wang
authors.forename: Xiao Feng
authors.initials: XF
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Mao Sheng
authors.initials: MS
authors.lastname: Yang
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D002681:China; D005006:Ethnicity / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008071:Lipoprotein Lipase / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011786:Quality Control; D012559:Schizophrenia / Q000201:enzymology / Q000235:genetics*; D012727:Sex Characteristics
chemical_list: C548261:LPL protein, human; D008071:Lipoprotein Lipase