title: The +874T/A polymorphism in the interferon-γ gene and tuberculosis risk: an update by meta-analysis.
abstract: The +874T/A polymorphism in the interferon-γ (IFN-γ) gene has been extensively examined for association to tuberculosis (TB); however, results of different studies have been inconsistent. The aim of this study was to comprehensively analyze the genetic risk of the +874T/A polymorphism in IFN-γ gene for TB by meta-analysis. A total of 4553 cases and 4631 controls in 21 case-control studies were included in this meta-analysis. The results indicated that the variant T allele carriers had a 27% decreased risk of TB, when compared with the homozygote AA (odds ratio [OR] = 0.73, 95% confidence interval [CI] = 0.61-0.87 for TT + TA versus AA). In the subgroup analysis by ethnicity, significant decreased risks were associated with T allele carriers in Asians (OR= 0.71, 95% CI = 0.52-0.97, p = 0.03) but not in Caucasians (OR = 0.87, 95% CI = 0.65-1.17, p = 0.37). Our results suggest that the IFN-γ +874T/A polymorphism contributes to susceptibility to TB.
authors.affiliation: Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
authors.forename: Can
authors.initials: C
authors.lastname: Tian
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Yao
authors.initials: Y
authors.lastname: Deng
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Li
authors.forename: Dan
authors.initials: D
authors.lastname: Xu
authors.forename: Honglang
authors.initials: H
authors.lastname: Huang
authors.forename: Jin
authors.initials: J
authors.lastname: Huang
authors.forename: Hong
authors.initials: H
authors.lastname: Fan
mesh_terms: D000818:Animals; D044466:Asian People; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D014376:Tuberculosis / Q000453:epidemiology* / Q000235:genetics* / Q000276:immunology; D044465:White People
chemical_list: D007371:Interferon-gamma