title: A comparative study of gastric banding and sleeve gastrectomy in an obese diabetic rat model.
abstract: BACKGROUND
  Laparoscopic sleeve gastrectomy (SG) is now a typical restrictive bariatric procedure. The aim of this study was to evaluate the efficacy of SG in comparison with gastric banding (GB) in an obese diabetic rat model.
  
  
  METHODS
  Forty-five male Zucker diabetic fatty rats were divided into three groups: sham-operated (SO) control, GB, and SG. The rats were followed for 6 weeks after surgery, and their body weight change, cumulative food intake, metabolic parameters, plasma levels of ghrelin, glucagon-like peptide-1 and adiponectin, oral glucose tolerance test (OGTT), insulin tolerance test (ITT), and gastric emptying rate were measured.
  
  
  RESULTS
  The GB and SG groups showed significant decreases in weight, cumulative intake, and metabolic parameters and significant improvement of OGTT and ITT results compared with the SO group. There were no significant differences in weight and cumulative food intake between the groups. However, the SG group showed significantly higher gastric emptying rate and plasma level of adiponectin and lower plasma levels of free fatty acid, total cholesterol, and ghrelin compared with the GB group. Furthermore, the SG group showed improvement of OGTT and ITT results in comparison with the GB group.
  
  
  CONCLUSIONS
  In obese diabetic rats, SG may improve glucose and lipid metabolism compared with GB, although there was no significant difference in the effect on body weight loss between the two procedures. The hormonal and digestive changes induced by SG may have relevance to the effects on metabolism.
authors.affiliation: Department of Surgery I, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita, 879-5593, Japan. tmasuda@oita-u.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Masuda
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ohta
authors.forename: Teijiro
authors.initials: T
authors.lastname: Hirashita
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Kawano
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Eguchi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yada
authors.forename: Yukio
authors.initials: Y
authors.lastname: Iwashita
authors.forename: Seigo
authors.initials: S
authors.lastname: Kitano
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000601:surgery*; D004195:Disease Models, Animal; D005743:Gastrectomy / Q000379:methods*; D015391:Gastroplasty / Q000379:methods*; D008297:Male; D009765:Obesity / Q000601:surgery*; D051381:Rats; D011924:Rats, Zucker