title: Seizures can precede cognitive symptoms in late-onset Alzheimer's disease.
abstract: This study describes late-onset Alzheimer's disease (LOAD) in the mild cognitive impairment (MCI) stage, debuting with seizures in a 72 year-old woman. Prodromal AD was consistently diagnosed with four among amyloidosis and neurodegeneration biomarkers about 1 year after onset of seizures. Genetic assessment demonstrated apolipoprotein E ε2/ε3 genotype and three intronic single nucleotide substitutions, two in presenilin 1 and one in amyloid-β protein precursor genes. This case of seizures at onset of LOAD with severe signs of brain amyloidosis and neurodegeneration but with just MCI leads to a re-appraisal of the intriguing relationship between AD pathology and neuron excitability in humans.
authors.affiliation: Clinical Neurophysiology, Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genoa, Italy.
authors.forename: Agnese
authors.initials: A
authors.lastname: Picco
authors.forename: Silvana
authors.initials: S
authors.lastname: Archetti
authors.forename: Michela
authors.initials: M
authors.lastname: Ferrara
authors.forename: Dario
authors.initials: D
authors.lastname: Arnaldi
authors.forename: Alessandra
authors.initials: A
authors.lastname: Piccini
authors.forename: Carlo
authors.initials: C
authors.lastname: Serrati
authors.forename: Diego
authors.initials: D
authors.lastname: di Lorenzo
authors.forename: Silvia
authors.initials: S
authors.lastname: Morbelli
authors.forename: Flavio
authors.initials: F
authors.lastname: Nobili
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D053318:Apolipoprotein E3 / Q000235:genetics; D003072:Cognition Disorders / Q000209:etiology*; D018450:Disease Progression; D004569:Electroencephalography; D005260:Female; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D049268:Positron-Emission Tomography; D012640:Seizures / Q000209:etiology*
chemical_list: D016564:Amyloid beta-Protein Precursor; D053318:Apolipoprotein E3; D019788:Fluorodeoxyglucose F18