title: Survey of antimicrobial resistance in clinical Burkholderia pseudomallei isolates over two decades in Northeast Thailand.
abstract: A 21-year survey conducted in northeast Thailand of antimicrobial resistance to parenteral antimicrobial drugs used to treat melioidosis identified 24/4,021 (0.6%) patients with one or more isolates resistant to ceftazidime (n = 8), amoxicillin-clavulanic acid (n = 4), or both drugs (n = 12). Two cases were identified at admission, and the remainder were detected a median of 15 days after starting antimicrobial therapy. Resistance to carbapenem drugs was not detected. These findings support the current prescribing recommendations for melioidosis.
authors.affiliation: Mahidol-Oxford Tropical Medicine Research Unit, Department of Microbiology and Immunology, Mahidol University, Bangkok, Thailand.
authors.forename: Vanaporn
authors.initials: V
authors.lastname: Wuthiekanun
authors.forename: Premjit
authors.initials: P
authors.lastname: Amornchai
authors.forename: Natnaree
authors.initials: N
authors.lastname: Saiprom
authors.forename: Narisara
authors.initials: N
authors.lastname: Chantratita
authors.forename: Wirongrong
authors.initials: W
authors.lastname: Chierakul
authors.forename: Gavin C K W
authors.initials: GC
authors.lastname: Koh
authors.forename: Wipada
authors.initials: W
authors.lastname: Chaowagul
authors.forename: Nicholas P J
authors.initials: NP
authors.lastname: Day
authors.forename: Direk
authors.initials: D
authors.lastname: Limmathurotsakul
authors.forename: Sharon J
authors.initials: SJ
authors.lastname: Peacock
mesh_terms: D019980:Amoxicillin-Potassium Clavulanate Combination / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016957:Burkholderia pseudomallei / Q000187:drug effects* / Q000472:pathogenicity*; D002442:Ceftazidime / Q000627:therapeutic use; D024881:Drug Resistance, Bacterial; D006801:Humans; D015378:Imipenem / Q000627:therapeutic use; D008554:Melioidosis / Q000188:drug therapy; D000077731:Meropenem; D013785:Thailand; D013845:Thienamycins / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D013845:Thienamycins; D015378:Imipenem; D019980:Amoxicillin-Potassium Clavulanate Combination; D002442:Ceftazidime; D000077731:Meropenem