title: Biomarker signatures of mitochondrial NDUFS3 in invasive breast carcinoma.
abstract: We present evidence for potential biomarker utility of a mitochondrial complex I subunit, (NDUFS3) in discriminating normal and highly invasive breast carcinoma specimens obtained from clinical patients. Besides being a robust indicator of breast cancer aggressiveness, NDUFS3 also shows clear signatures of a hypoxia/necrosis marker in invasive ductal carcinoma specimens. Statistically significant positive correlation was observed between nuclear grade and NDUFS3 expression level in the tumor specimens analyzed. We support these findings with a plausible mechanism involving mitochondrial complex I assembly defects and/or redox buffering induced mitochondrial dysfunction during the process of cancer cell transformation. From a clinical standpoint, this novel observation adds value in augmenting the current receptor-based biomarkers for better accuracy in diagnosis and predicting survival rate in patients with breast carcinoma.
authors.affiliation: Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
authors.forename: Sonal
authors.initials: S
authors.lastname: Suhane
authors.forename: Dror
authors.initials: D
authors.lastname: Berel
authors.forename: V Krishnan
authors.initials: VK
authors.lastname: Ramanujan
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D001943:Breast Neoplasms / Q000201:enzymology / Q000401:mortality / Q000473:pathology*; D002277:Carcinoma / Q000201:enzymology / Q000473:pathology*; D005260:Female; D006801:Humans; D008928:Mitochondria / Q000201:enzymology*; D009245:NADH Dehydrogenase / Q000235:genetics / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D034741:RNA, Small Interfering / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D034741:RNA, Small Interfering; D009245:NADH Dehydrogenase; C472512:NDUFS3 protein, human