title: Preparation and characterization of metformin hydrochloride loaded-Eudragit®RSPO and Eudragit®RSPO/PLGA nanoparticles.
abstract: The aim of the present study was to develop and characterize metformin HCl-loaded nanoparticle formulations. Nanoparticles were prepared by the nanoprecipitation method using both a single polymer (Eudragit(®)RSPO) and a polymer mixture (Eudragit/PLGA). The mean particle size ranged from 268.8 to 288 nm and the nanoparticle surface was positively charged (9.72 to 10.1 mV). The highest encapsulation efficiency was observed when Eudragit®RSPO was used. All formulations showed highly reproducible drug release profiles and the in vitro drug release in phosphate buffer (pH = 6.8) ranged from 92 to 100% in 12 h. These results suggest that Eudragit(®)RSPO or Eudragit/PLGA nanoparticles might represent a promising sustained-release oral formulation for metformin HCl, reducing the necessity of repeated administrations of high doses to maintain effective plasma concentrations, and thus, increasing patient compliance and reducing the incidence of side-effects.
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, Ataturk University, 25240, Erzurum, Turkey. melcetin@hotmail.com
authors.forename: Meltem
authors.initials: M
authors.lastname: Cetin
authors.forename: Alptug
authors.initials: A
authors.lastname: Atila
authors.forename: Selma
authors.initials: S
authors.lastname: Sahin
authors.forename: Imran
authors.initials: I
authors.lastname: Vural
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000138:chemical synthesis / Q000493:pharmacokinetics; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D006801:Humans; D019344:Lactic Acid / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D008687:Metformin / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D053758:Nanoparticles / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011109:Polymethacrylic Acids / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D015203:Reproducibility of Results
chemical_list: D003692:Delayed-Action Preparations; C496966:Eudragit RSPO; D011109:Polymethacrylic Acids; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D008687:Metformin