title: Nephroprotective and antioxidant activities of Salacia oblonga on acetaminophen-induced toxicity in rats.
abstract: Salacia oblonga, a woody climbing plant belonging to the family Celastaceae, is widely distributed in India and other southeast Asian countries. The genus Salacia have been used particularly for the treatment of diabetes, obesity, gonorrhoea, rheumatism, pruritus and asthma. Acetaminophen (APAP), used as an analgesic drug, produces liver and kidney necrosis in mammals at high doses. The aim of this study was to investigate the nephroprotective and antioxidant activities of the ethanol extract of Salacia oblonga (EESO) at the two dose levels of 250 and 500 mg/kg bw on APAP-induced toxicity in rats. The results showed that APAP significantly increases the levels of serum urea, creatinine, and reduces levels of uric acid concentration. The EESO reduces these by increasing anti-oxidative responses as assessed by biochemical and histopathological parameters. In conclusion, our results suggest that the EESO possesses nephroprotective and antioxidant effects against APAP-induced nephrotoxicity in rats.
authors.affiliation: Department of Biotechnology, Anna Bioresearch Foundation, Arunai Engineering College, Tiruvannamalai, Tamil Nadu, India. spalanitvm@gmail.com
authors.forename: S
authors.initials: S
authors.lastname: Palani
authors.forename: S
authors.initials: S
authors.lastname: Raja
authors.forename: S Nirmal
authors.initials: SN
authors.lastname: Kumar
authors.forename: B Senthil
authors.initials: BS
authors.lastname: Kumar
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects*; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D003401:Creatine / Q000097:blood; D004305:Dose-Response Relationship, Drug; D000431:Ethanol; D007673:Kidney Cortex Necrosis / Q000139:chemically induced* / Q000188:drug therapy*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D049918:Salacia / Q000737:chemistry*; D014508:Urea / Q000097:blood; D014527:Uric Acid / Q000097:blood
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D014527:Uric Acid; D000082:Acetaminophen; D000431:Ethanol; D014508:Urea; D003401:Creatine