title: Dopamine D1 receptor antagonism impairs extinction of cocaine-cue memories.
abstract: Increasingly, research suggests a role for dopamine D1 receptors in the consolidation of extinction of both appetitive and aversive memories. However, a role for D1 receptors in extinction of memories involving drug reward has yet to be established. Here we show that post-retrieval, but not delayed, systemic administration of the D1 receptor antagonist SCH23390 results in prolonged extinction of cocaine conditioned place preference (CPP), suggesting a critical role for D1 receptors in the consolidation of extinction of cocaine-cue memories.
authors.affiliation: University of California, Irvine. Department of Neurobiology & Behavior, 2205 McGaugh Hall, Irvine, CA 92697-4550, USA.
authors.forename: Ashley N
authors.initials: AN
authors.lastname: Fricks-Gleason
authors.forename: Anna J
authors.initials: AJ
authors.lastname: Khalaj
authors.forename: John F
authors.initials: JF
authors.lastname: Marshall
mesh_terms: D000818:Animals; D001245:Association Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D001552:Benzazepines / Q000494:pharmacology*; D003042:Cocaine / Q000494:pharmacology*; D003213:Conditioning, Psychological / Q000187:drug effects; D003463:Cues; D018492:Dopamine Antagonists / Q000494:pharmacology*; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D005108:Extinction, Psychological / Q000187:drug effects* / Q000502:physiology; D008568:Memory / Q000187:drug effects*; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors*
chemical_list: D001552:Benzazepines; D018492:Dopamine Antagonists; D018765:Dopamine Uptake Inhibitors; D017447:Receptors, Dopamine D1; C534628:SCH 23390; D003042:Cocaine