title: [Morphogenesis of gastric mucosal atrophy as a basis of a phenotype of chronic gastritis].
abstract: Atrophic antral gastritis was found to show an absolute decrease in gland volume with higher expression of the gastric transcription factor Shh, i.e. absolute atrophy and that concurrent with the replacement of the specialized gastric epithelium by the intestinal MUC2-producing one, i.e. metaplastic atrophy. In atrophic multifocal gastritis along absolute and metaplastic atrophy, there are foci of the proliferative metaplastic epithelium, i.e. hyperproliferative metaplastic atrophy that is prevalent in atrophic pangastritis. The molecular characteristics of hyperproliferative metaplastic atrophy are varying: in some foci of metaplasia, the high proliferative activity of the epithelium is concomitant with the hyperexpression of P53, a marker of DNA damage, the lower expression of the intestinal transcription factor CDX-2, and the low level of Cpp32, an indicator of apoptosis. Whether such structures can be identified at the launching pad for tumor growth in atrophic pangastritis is discussed.
authors.forename: A V
authors.initials: AV
authors.lastname: Kononov
authors.forename: S I
authors.initials: SI
authors.lastname: Mosgovoĭ
authors.forename: M V
authors.initials: MV
authors.lastname: Markelova
authors.forename: A G
authors.initials: AG
authors.lastname: Shimanskaia
mesh_terms: D017209:Apoptosis; D001284:Atrophy / Q000378:metabolism / Q000473:pathology; D015415:Biomarkers / Q000378:metabolism; D000071616:CDX2 Transcription Factor; D053148:Caspase 3 / Q000096:biosynthesis; D002908:Chronic Disease; D004249:DNA Damage; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism* / Q000473:pathology*; D005757:Gastritis, Atrophic / Q000378:metabolism* / Q000473:pathology*; D053823:Hedgehog Proteins / Q000096:biosynthesis; D018398:Homeodomain Proteins / Q000096:biosynthesis; D006801:Humans; D008297:Male; D008679:Metaplasia / Q000378:metabolism / Q000473:pathology; D055262:Mucin-2 / Q000096:biosynthesis; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis
chemical_list: D015415:Biomarkers; D000071616:CDX2 Transcription Factor; C491270:CDX2 protein, human; D053823:Hedgehog Proteins; D018398:Homeodomain Proteins; C524625:MUC2 protein, human; D055262:Mucin-2; C509239:SHH protein, human; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C505407:CASP3 protein, human; D053148:Caspase 3