title: Pistagremic acid a new leishmanicidal triterpene isolated from Pistacia integerrima Stewart.
abstract: The present study was designed to investigate the whole plant of Pistacia integerrima Stewart in order to examine the pharmacological basis of the use of the plant in folk medicine for the treatment of infectious diseases and disorder. Phytochemical and pharmacological studies led to the isolation of a new triterpene pistagremic acid (3-methyl-7-(4,4,10,13,14-pentamethyl-3-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-oct-3-enoic). Pistagremic acid showed significant leishmanicidal activity (IC(50): 6.71 ± 0.09 µM) against Leishmania major (DESTO) promastigotes in comparison to standard compound amphotericin B (IC(50): 0.21 ± 0.06 µM).
authors.affiliation: Institute of Chemical Sciences, Centre for Phytomedicine & Medicinal Organic Chemistry, University of Peshawar, Peshawar, Pakistan. drghiasuddin@hotmail.com
authors.forename: Ghias
authors.initials: G
authors.lastname: Uddin
authors.forename: Abdur
authors.initials: A
authors.lastname: Rauf
authors.forename: Mohammad
authors.initials: M
authors.lastname: Arfan
authors.lastname: Waliullah
authors.forename: Inamullah
authors.initials: I
authors.lastname: khan
authors.forename: Mumtaz
authors.initials: M
authors.lastname: Ali
authors.forename: Mazhar
authors.initials: M
authors.lastname: Taimur
authors.forename: Inaayat
authors.initials: I
authors.lastname: ur-Rehman
authors.lastname: Samiullah
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D000882:Haplorhini; D007891:Leishmania / Q000187:drug effects*; D051379:Mice; D027927:Pistacia / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000981:Antiprotozoal Agents; D014315:Triterpenes; C581170:pistagremic acid