title: [Accumulation of porphyrins in cells of system of blood induced by 5-aminolaevulinic acid].
abstract: The levels and rates of accumulation of porphyrins in lymphoid cells and bone marrow cells treated with exogenous 5-aminolaevulinic acid (ALA) were studied. The dependence of the quantity of porphyrins accumulated in cell on ALA concentrations in the medium had maximum at 0.7-1.0 mM ALA for all the cell types studied (splenocytes, thymocytes, peripheral blood lymphocytes and bone marrow cells). The rate of accumulation of uro-, copro- and protoporphyrins depended on cell types. The lowest and the highest levels were found in splenocytes and highest in bone marrow cells respectively. It is suggested that photodynamic therapy employing ALA is potentially dangerous for blood cells.
authors.forename: E S
authors.initials: ES
authors.lastname: Lobanok
authors.forename: I B
authors.initials: IB
authors.lastname: Vasilevich
authors.forename: A V
authors.initials: AV
authors.lastname: Vorobeĭ
mesh_terms: D000622:Aminolevulinic Acid / Q000494:pharmacology*; D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000378:metabolism*; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D008214:Lymphocytes / Q000166:cytology / Q000378:metabolism*; D017319:Photosensitizing Agents / Q000494:pharmacology*; D011166:Porphyrins / Q000378:metabolism*; D051381:Rats; D013154:Spleen / Q000166:cytology / Q000378:metabolism*
chemical_list: D017319:Photosensitizing Agents; D011166:Porphyrins; D000622:Aminolevulinic Acid