title: 5-deoxyflavones with cytotoxic activity from Mimosa diplotricha.
abstract: Bioassay-guided isolation of Mimosa diplotricha led to the isolation of four new 5-deoxyflavones, diplotrins A-C (1-3) and diplotasin (4), together with 12 known flavonoids, flavonolignans, and triterpenoids. On the basis of spectroscopic evidence, compounds 1-4 were characterized as 2',5'-dihydroxy-3,7,8,4'-tetramethoxyflavone (1), 3'-hydroxy-3,7,8,4'-tetramethoxyflavone (2), 2'-hydroxy-7,4',5'-trimethoxyflavone (3), and 4-hydroxy-3,10,11-trimethoxyisochromeno-[4,3-b]-chromen-7(5H)-one (4). The cytotoxic effects of these isolated compounds were evaluated against the A549, AGS, HT-29, and PC3 human cancer cell lines. Compounds 2 and 5″-methoxyhydnocarpin-D (5) showed the most potent antiproliferative activity.
authors.affiliation: National Research Institute of Chinese Medicine, Taipei, Taiwan, Republic of China. lclin@nricm.edu.tw
authors.forename: Lie-Chwen
authors.initials: LC
authors.lastname: Lin
authors.forename: Chun-Tang
authors.initials: CT
authors.lastname: Chiou
authors.forename: Jing-Jy
authors.initials: JJ
authors.lastname: Cheng
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019073:HT29 Cells; D006801:Humans; D031298:Mimosa / Q000737:chemistry*; D015394:Molecular Structure; D013624:Taiwan
chemical_list: C405502:5'-methoxyhydnocarpin; D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids