title: Integrative etiopathogenetic models of psychotic disorders: methods, evidence and concepts.
abstract: Integrative models of the etiopathogesnesis of psychotic disorders are needed since a wealth of information from such diverse fields as neurobiology, psychology, and the social sciences is currently changing the concepts of mental disorders. Several approaches to integrate these streams of information into coherent concepts of psychosis are feasible and will need to be assessed in future experimental studies. Common to these concepts are the notion of psychotic disorders as brain disorders and a polythetic approach in that it is increasingly realized that a multitude of interindividually partially different pathogenetic factors interact in individual persons in a complex fashion resulting in the clinical symptoms of psychosis.
authors.affiliation: Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine University, LVR-Klinikum Düsseldorf, Bergische Landstrasse 2, D-40629 Düsseldorf, Germany. wolfgang.gaebel@uni-duesseldorf.de
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Gaebel
authors.forename: Jürgen
authors.initials: J
authors.lastname: Zielasek
mesh_terms: D039721:Diagnostic and Statistical Manual of Mental Disorders; D006801:Humans; D038801:International Classification of Diseases; D008959:Models, Neurological; D011618:Psychotic Disorders / Q000145:classification / Q000209:etiology / Q000503:physiopathology; D012307:Risk Factors; D012559:Schizophrenia / Q000145:classification / Q000209:etiology / Q000503:physiopathology; D012565:Schizophrenic Psychology