title: Anaplastic large cell lymphoma of the esophagus in a pediatric patient.
abstract: We report a 3-year-old boy who initially presented with abdominal pain and was subsequently found to have an esophageal perforation. The child did not respond to conservative management, and subsequent lymphadenopathy led to a lymph node biopsy demonstrating an anaplastic lymphoma kinase (ALK)+ anaplastic large cell lymphoma. Esophageal perforation and thickening is most commonly seen in children with a history of esophageal intervention or foreign body/caustic ingestion. Esophageal involvement in children with non-Hodgkin lymphoma (NHL) has not, to our knowledge, been reported in the literature. This case illustrates an unusual presentation of pediatric NHL.
authors.affiliation: Department of Radiology, Children's Hospital Boston and Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Anastasia L
authors.initials: AL
authors.lastname: Hryhorczuk
authors.forename: Marian H
authors.initials: MH
authors.lastname: Harris
authors.forename: Sara O
authors.initials: SO
authors.lastname: Vargas
authors.forename: Edward Y
authors.initials: EY
authors.lastname: Lee
mesh_terms: D002675:Child, Preschool; D003937:Diagnosis, Differential; D004939:Esophageal Perforation / Q000175:diagnosis* / Q000209:etiology; D004945:Esophagoscopy; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed