title: New strategies in neuroprotection and neurorepair.
abstract: There are currently few clinical strategies in place, which provide effective neuroprotection and repair, despite an intense international effort over the past decades. One possible explanation for this is that a deeper understanding is required of how endogenous mechanisms act to confer neuroprotection. This mini-review reports the proceedings of a recent workshop "Neuroprotection and Neurorepair: New Strategies" (Iguazu Falls, Misiones, Argentina, April 11-13, 2011, Satellite Symposium of the V Neurotoxicity Society Meeting, 2011) in which four areas of active research were identified to have the potential to generate new insights into this field. Topics discussed were (i) metallothionein and other multipotent neuroprotective molecules; (ii) oxidative stress and their signal mediated pathways in neuroregeneration; (iii) neurotoxins in glial cells, and (iv) drugs of abuse with neuroprotective effects.
authors.affiliation: Instituto de Química y Fisicoquímica Biológicas (UBA-CONICET), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, C1113AAD, Buenos Aires, Argentina. mca@ffyb.uba.ar
authors.forename: Marta C
authors.initials: MC
authors.lastname: Antonelli
authors.forename: Gilles J
authors.initials: GJ
authors.lastname: Guillemin
authors.forename: Rita
authors.initials: R
authors.lastname: Raisman-Vozari
authors.forename: Elaine A
authors.initials: EA
authors.lastname: Del-Bel
authors.forename: Michael
authors.initials: M
authors.lastname: Aschner
authors.forename: Michael A
authors.initials: MA
authors.lastname: Collins
authors.forename: Yousef
authors.initials: Y
authors.lastname: Tizabi
authors.forename: Rosario
authors.initials: R
authors.lastname: Moratalla
authors.forename: Adrian K
authors.initials: AK
authors.lastname: West
mesh_terms: D002490:Central Nervous System / Q000187:drug effects; D008668:Metallothionein / Q000032:analysis / Q000378:metabolism*; D009416:Nerve Regeneration; D009457:Neuroglia / Q000378:metabolism; D018696:Neuroprotective Agents / Q000378:metabolism* / Q000494:pharmacology; D009498:Neurotoxins / Q000633:toxicity*; D018384:Oxidative Stress / Q000502:physiology*; D019966:Substance-Related Disorders / Q000378:metabolism
chemical_list: D018696:Neuroprotective Agents; D009498:Neurotoxins; D008668:Metallothionein