title: Candidate genes and risk for CP: a population-based study.
abstract: Studies suggest that genetic polymorphisms may increase an individual's susceptibility to CP. Most findings have yet to be corroborated in an independent cohort. This case-control study is nested within all 334,333 infants ≥36 wk gestation born at Kaiser Permanente Medical Care Program, 1991-2002. We included only non-Hispanic whites who had a neonatal blood sample available. Case patients (n = 138) were identified from medical records to have spastic or dyskinetic CP. Controls (n = 165) were randomly selected from the population. We genotyped polymorphisms previously associated with CP: inducible NOS (iNOS)-231, apolipoprotein E (apoE) ε2 and ε4 alleles, TNF-α-308, IL-8 -251, lymphotoxin 60, endothelial NOS -922, endothelial protein C receptor 219, mannose-binding lectin 54 and 52, factor V Leiden, methyltetrahydrofolate reductase 1298 and 667, prothrombin 20210, and platelet activator inhibitor 11053. Similar to previous reports, the iNOS-231 T allele (25.7 versus 18.9%, p = 0.04) and the apoE ε4 allele (19.3 versus 13.2%, p = 0.04) were more common in patients with CP than in controls. However, there was no statistically significant association between any genetic polymorphism and CP after correction for multiple comparisons.
authors.affiliation: Department of Neurology, University of California, San Francisco, California 94143, USA. wuy@neuropeds.ucsf.edu
authors.forename: Yvonne W
authors.initials: YW
authors.lastname: Wu
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Croen
authors.forename: Andrew
authors.initials: A
authors.lastname: Vanderwerf
authors.forename: Amy A
authors.initials: AA
authors.lastname: Gelfand
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Torres
mesh_terms: D001057:Apolipoproteins E / Q000235:genetics*; D002140:California; D016022:Case-Control Studies; D002547:Cerebral Palsy / Q000235:genetics*; D005453:Fluorescence; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007223:Infant; D016015:Logistic Models; D052247:Nitric Oxide Synthase Type II / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D001057:Apolipoproteins E; D052247:Nitric Oxide Synthase Type II