title: Inhibition effects of isolated compounds from Artemisia rubripes Nakai of the classical pathway on the complement system.
abstract: The study evaluated the anticomplement activity from isolated compounds from Artemisia rubripes Nakai from South Korea on the classical pathway. In the previous works, Artemisia rubripes chloroform extracts showed inhibitory activity against complement system. The chromatographic separation of a chloroform chloride extract of Artemisia rubripes led to the isolation of three compounds. Their structures were characterized to be scopoletin (1), 11,(13)-triene-6,12-olide (2), and 1β,6α-dihydroxy-4(15)-eudesmene (3) by spectroscopic data. This is the first report of anticomplement activity of isolated compounds from Artemisia rubripes.
authors.affiliation: Department of Urology, College of Medicine, Dong-A University, Busan 602-714, South Korea.
authors.forename: Seil
authors.initials: S
authors.lastname: Jung
authors.forename: Jai-Heon
authors.initials: JH
authors.lastname: Lee
authors.forename: Young-Choon
authors.initials: YC
authors.lastname: Lee
authors.forename: Hyung-In
authors.initials: HI
authors.lastname: Moon
mesh_terms: D000818:Animals; D019306:Artemisia / Q000737:chemistry*; D002725:Chloroform / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D002934:Cinnamates / Q000494:pharmacology; D051056:Complement Inactivating Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D003171:Complement Pathway, Classical / Q000187:drug effects*; D053630:Depsides / Q000494:pharmacology; D005419:Flavonoids / Q000494:pharmacology; D006461:Hemolysis / Q000276:immunology; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D011817:Rabbits; D012603:Scopoletin / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012756:Sheep; D000097123:Rosmarinic Acid
chemical_list: D002725:Chloroform; D002934:Cinnamates; D051056:Complement Inactivating Agents; D053630:Depsides; D005419:Flavonoids; D010936:Plant Extracts; D012603:Scopoletin; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane; D000097123:Rosmarinic Acid; C052083:tiliroside