title: No association of MTHFR c.677C>T variant with sporadic ALS in an Italian population.
abstract: The c.677C>T polymorphism in the 5,10-methylenetetrahydrofolate reductase gene (MTHFR) has been recently associated with susceptibility to sporadic amyotrophic lateral sclerosis (ALS). We have investigated this association in 450 ALS patients and 700 control subjects from Italy. No significant association was observed at the genotype and allelic level, either for the c.677C>T variant alone or in combination with PON1 polymorphisms. Our negative results suggest that the MTHFR c.677C>T polymorphism is not a risk factor for ALS in the Italian population.
authors.affiliation: Department of Neurological, Neurosurgical and Behavioural Sciences, Neurology Section, University of Siena, Siena, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Ricci
authors.forename: Silvana
authors.initials: S
authors.lastname: Penco
authors.forename: Michele
authors.initials: M
authors.lastname: Benigni
authors.forename: Lorena
authors.initials: L
authors.lastname: Mosca
authors.forename: Claudia
authors.initials: C
authors.lastname: Tarlarini
authors.forename: Christian
authors.initials: C
authors.lastname: Lunetta
authors.forename: Fabio
authors.initials: F
authors.lastname: Giannini
authors.forename: Massimo
authors.initials: M
authors.lastname: Corbo
authors.forename: Stefania
authors.initials: S
authors.lastname: Battistini
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics*; D043303:Aryldialkylphosphatase / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D006710:Homocysteine / Q000097:blood; D006801:Humans; D007558:Italy; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D011110:Polymorphism, Genetic; D013763:Tetrahydrofolates
chemical_list: D013763:Tetrahydrofolates; D006710:Homocysteine; C013123:5,10-methylenetetrahydrofolic acid; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D043303:Aryldialkylphosphatase; C468406:PON1 protein, human