title: Anaplastic atypical myeloma with extensive cutaneous involvement in a dog.
abstract: A 7-year-old, male, mixed breed dog was referred to the Veterinary Teaching Hospital at Kitasato University because of anorexia, lameness and multiple cutaneous lesions. Observation of bone marrow plasmacytosis, osteolytic bone lesions, serum myeloma protein and cutaneous infiltration of myeloma cells led us to a diagnosis of multiple myeloma (MM) with cutaneous involvement. Polymerase chain reaction and sequence analysis for the rearranged genes of immunoglobulin and T-cell receptor demonstrated that the neoplastic cells found in skin lesions or bone marrow are of B-lymphocyte lineage and share a common original precursor cell. The dog was treated with UW-Madison protocol or melphalan/prednisone protocol and survived 175 days. This is rare case of anaplastic MM with cutaneous involvement in dog.
authors.affiliation: Veterinary Internal Medicine, Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Fukumoto
authors.forename: Kiwamu
authors.initials: K
authors.lastname: Hanazono
authors.forename: Naomi
authors.initials: N
authors.lastname: Kawasaki
authors.forename: Yasutomo
authors.initials: Y
authors.lastname: Hori
authors.forename: Seiichi
authors.initials: S
authors.lastname: Higuchi
authors.forename: Takushi
authors.initials: T
authors.lastname: Sasaki
authors.forename: Kyosuke
authors.initials: K
authors.lastname: Temma
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Uchide
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols; D004283:Dog Diseases / Q000188:drug therapy / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D008130:Lomustine / Q000627:therapeutic use; D008297:Male; D008558:Melphalan / Q000008:administration & dosage / Q000627:therapeutic use; D009101:Multiple Myeloma / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*
chemical_list: D008130:Lomustine; D011239:Prednisolone; D008558:Melphalan