title: Single nucleotide polymorphisms of matrix metallopeptidase 3 and risk of gliomas in a Chinese Han population.
abstract: Matrix metallopeptidases (MMPs) play an important role in central nervous system tumor growth, invasion and spreading. The currently available data provide clear evidence for the involvement of MMP3 in the pathophysiology of glioma. The study aims to explore the association of single nucleotide polymorphisms (SNPs) across the MMP3 gene with glioma risk. Three haplotype tagging and additional two promoter SNPs were genotyped among 766 glioma patients and 824 cancer-free controls from East China. None of these polymorphisms alone had a significant effect on risk of gliomas. However, when three promoter polymorphisms were evaluated together by the number of putative risk of genotypes (i.e., rs645419AA, 632478CA+AA, rs522616AA), a statistically significantly increased risk of gliomas was associated with the combined genotypes with two to three risk genotypes, compared with those with zero to one risk genotypes (adjusted odds ratio (OR) = 1.32; 95% confidence interval (CI) = 1.03-1.68). This increased risk was also more pronounced among adults (adjusted OR = 1.14, 95%CI = 1.02-1.27), males (adjusted OR = 1.19, 95%CI = 1.05-1.36), smokers (adjusted OR = 1.28, 95%CI = 1.07-1.52), subjects with no family history of cancer (adjusted OR = 1.21, 95%CI = 1.07-1.37), and patients with nonastrocytic gliomas (adjusted OR = 1.23, 95%CI = 1.06-1.43). In summary, our results suggest that any one of MMP3 variants may not have a substantial effect on glioma risk, but a joint effect of MMP3 promoter polymorphisms may contribute to risk of gliomas, particularly for adult gliomas.
authors.affiliation: State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes for Biomedical Sciences, Fudan University, Shanghai, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Fan
authors.forename: Keke
authors.initials: K
authors.lastname: Zhou
authors.forename: Dezhi
authors.initials: D
authors.lastname: Hu
authors.forename: Xiao
authors.initials: X
authors.lastname: Song
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Zhao
authors.forename: Hongyan
authors.initials: H
authors.lastname: Chen
authors.forename: Qingyi
authors.initials: Q
authors.lastname: Wei
authors.forename: Gong
authors.initials: G
authors.lastname: Chen
authors.forename: Jinlong
authors.initials: J
authors.lastname: Shi
authors.forename: Guhong
authors.initials: G
authors.lastname: Du
authors.forename: Ying
authors.initials: Y
authors.lastname: Mao
authors.forename: Daru
authors.initials: D
authors.lastname: Lu
authors.forename: Liangfu
authors.initials: L
authors.lastname: Zhou
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D016543:Central Nervous System Neoplasms / Q000235:genetics*; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D005910:Glioma / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D019278:Matrix Metalloproteinase 3 / Q000235:genetics*; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D012307:Risk Factors
chemical_list: D019278:Matrix Metalloproteinase 3