title: Enhanced ROS production and cell death through combined photo- and sono-activation of conventional photosensitising drugs.
abstract: A combination of light and ultrasound activation of two conventional photosensitising drugs, methylene blue and rose bengal, was shown to generate higher levels of reactive oxygen species (ROS) and lower LD50 values than either light or ultrasound activation alone.
authors.affiliation: Department of Pharmacy and Pharmaceutical Sciences, School of Biomedical Sciences, The University of Ulster, Northern Ireland BT52 1SA, United Kingdom.
authors.forename: Bridgeen
authors.initials: B
authors.lastname: McCaughan
authors.forename: Claire
authors.initials: C
authors.lastname: Rouanet
authors.forename: Colin
authors.initials: C
authors.lastname: Fowley
authors.forename: Nikolitsa
authors.initials: N
authors.lastname: Nomikou
authors.forename: Anthony P
authors.initials: AP
authors.lastname: McHale
authors.forename: Paul A
authors.initials: PA
authors.lastname: McCarron
authors.forename: John F
authors.initials: JF
authors.lastname: Callan
mesh_terms: D000818:Animals; D016466:CHO Cells; D016923:Cell Death; D045744:Cell Line, Tumor; D002470:Cell Survival; D006224:Cricetinae; D004353:Drug Evaluation, Preclinical; D007928:Lethal Dose 50; D008027:Light; D008751:Methylene Blue / Q000737:chemistry / Q000494:pharmacology*; D010084:Oxidation-Reduction; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012395:Rose Bengal / Q000378:metabolism / Q000494:pharmacology*; D013016:Sound
chemical_list: D017319:Photosensitizing Agents; D017382:Reactive Oxygen Species; D012395:Rose Bengal; D008751:Methylene Blue