title: Impact of an intervention designed to improve the documentation of the reassessment of antibiotic therapies in an intensive care unit.
abstract: OBJECTIVE
  The study objectives were: (i) to design an intervention to improve the written documentation of empiric antibiotic prescriptions' reassessment; (ii) and to assess the impact of this intervention on the quality of prescriptions.
  
  
  METHODS
  A prospective before and after 7-month intervention study in a medical ICU in a French teaching hospital, using interrupted time-series analysis. The intervention was made to improve the documentation of four process measures in medical records: antibiotic plan, reviewing the diagnosis, adapting to positive microbiological results, and IV-per os switch.
  
  
  RESULTS
  One hundred and fourteen antibiotic prescriptions were assessed, 62 before and 52 after the intervention. The reassessment of antibiotic prescriptions was more often documented in the ICU after the intervention (P=0.03 for sudden change). The prevalence of appropriate antibiotic prescriptions was not statistically different before and after the intervention, either for sudden change and/or linear trend.
  
  
  CONCLUSIONS
  A better documentation of antibiotic prescriptions' reassessment was achieved in this ICU, but it did not improve the quality of antibiotic prescriptions.
authors.affiliation: Service d'infectiologie, hôpital l'Archet-1, centre hospitalier universitaire de Nice, 151 route Saint-Antoine-de-Ginestière, Nice cedex 3, France. pulcini.c@chu-nice.fr
authors.forename: C
authors.initials: C
authors.lastname: Pulcini
authors.forename: J
authors.initials: J
authors.lastname: Dellamonica
authors.forename: G
authors.initials: G
authors.lastname: Bernardin
authors.forename: N
authors.initials: N
authors.lastname: Molinari
authors.forename: A
authors.initials: A
authors.lastname: Sotto
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019985:Benchmarking; D011307:Drug Prescriptions / Q000592:standards*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D000900:Anti-Bacterial Agents