title: Biomarkers to optimize antibiotic therapy for pneumonia due to multidrug-resistant pathogens.
abstract: No currently available biomarker can be used as a diagnostic marker for ventilator-associated pneumonia due to multidrug-resistant pathogens. Procalcitonin can be used to customize the duration of antimicrobial treatment without excess morbidity and mortality: when its concentration is less than 0.5 ng/mL or has decreased by 80% or more compared with the peak concentration, antibiotics can be stopped. With this strategy, extreme vigilance must be maintained after terminating antimicrobial therapy to detect a recurrent infection.
authors.affiliation: Service de Réanimation Médicale, Institut de Cardiologie, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, France. charles-edouard.luyt@psl.aphp.fr
authors.forename: Charles-Edouard
authors.initials: CE
authors.lastname: Luyt
authors.forename: Alain
authors.initials: A
authors.lastname: Combes
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Trouillet
authors.forename: Jean
authors.initials: J
authors.lastname: Chastre
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D002097:C-Reactive Protein / Q000378:metabolism*; D002116:Calcitonin / Q000378:metabolism*; D015740:Calcitonin Gene-Related Peptide; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism; D018410:Pneumonia, Bacterial / Q000188:drug therapy / Q000378:metabolism*; D053717:Pneumonia, Ventilator-Associated / Q000188:drug therapy / Q000378:metabolism* / Q000382:microbiology; D011498:Protein Precursors / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000378:metabolism; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D008562:Membrane Glycoproteins; D011498:Protein Precursors; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide