title: Therapeutic potential of c-Myc inhibition in the treatment of hypertrophic cardiomyopathy.
abstract: Investigating the pathophysiological importance of the molecular and mechanical development of cardiomyopathy is critical to find new and broader means of protection against this disease that is increasing in prevalence and impact. The current available treatment options for cardiomyopathy mainly focus on treating symptoms and strive to make the patient more comfortable while preventing progression of disease and sudden death. The proto-oncogene c-Myc (Myc) has been shown to be increased in many different types of heart disease, including hypertrophic cardiomyopathy, before any signs of the disease are present. As the mechanisms of action and multiple pathways of dependent actions of Myc are being dissected by many research groups, inhibition of Myc is becoming an attractive paradigm for prevention and treatment of cardiomyopathy and heart failure. Elucidating the role Myc plays in the development, propagation and perpetuation of cardiomyopathy and heart failure will one day translate into potential therapeutics for cardiomyopathy.
authors.affiliation: Department of Pathology, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Wolfram
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Lesnefsky
authors.forename: Brian D
authors.initials: BD
authors.lastname: Hoit
authors.forename: Mark A
authors.initials: MA
authors.lastname: Smith
authors.forename: Hyoung-Gon
authors.initials: HG
authors.lastname: Lee