title: Progressive static pulmonary hyperinflation in survivors of severe bronchopulmonary dysplasia by mid-adulthood.
abstract: BACKGROUND
  Severe bronchopulmonary dysplasia (BPD) might be associated with an accelerated age-related decline of lung function.
  
  
  METHODS
  14 individuals were studied longitudinally at 15±4, 18±3 and 38±3.2 years. Information on personal history was completed, and lung function testing and skin prick testing were performed. Longitudinal data were compared intra-individually and with matched controls from the NHANES III dataset.
  
  
  RESULTS
  The ratio of residual volume/total lung capacity (RV/TLC) increased markedly from 25.9±7.0% to 39.3±6.8%. A significant time-effect was found compared to controls for the forced vital capacity (FVC) which decreased more rapidly than expected. Flow values were at the lower limit of normal range but remained relatively stable over time. Some individuals had completely normal lung function results.
  
  
  CONCLUSIONS
  Increasing static pulmonary hyperinflation with age is indicative of bronchiolar dysfunction or early emphysematous changes in survivors of severe BPD. Susceptibility for long-term sequelae shows significant variability.
authors.forename: Daniel
authors.initials: D
authors.lastname: Trachsel
authors.forename: Martin H
authors.initials: MH
authors.lastname: Brutsche
authors.forename: Henriette
authors.initials: H
authors.lastname: Hug-Batschelet
authors.forename: Jürg
authors.initials: J
authors.lastname: Hammer
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000503:physiopathology*; D002648:Child; D018450:Disease Progression; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008297:Male; D014109:Total Lung Capacity / Q000502:physiology*