title: Association study of HLA-B alleles with idiopathic male infertility in Han population of China.
abstract: OBJECTIVE
  To investigate the distributions of HLA-B alleles and estimate their associations with idiopathic male infertility in Chinese Han population.
  
  
  METHODS
  Polymerase chain reaction-sequence-based typing (PCR-SBT) method was used for DNA typing at HLA-B locus in 109 patients with idiopathic male infertility and 152 healthy controls in male Han population of Shaanxi Province, situated in northwestern China.
  
  
  RESULTS
  In total, we detected 45 HLA-B alleles in idiopathic infertile patients, 48 HLA-B alleles in control subjects. However, no significant differences of these allelic frequencies were found between the infertile patients and the controls.
  
  
  CONCLUSIONS
  HLA-B gene was unlikely a major risk factor of idiopathic male infertility in this sample population. As different populations have different HLA polymorphisms, investigation of the relationship of other HLA genes and idiopathic male infertility with larger sample size, is warranted in the future.
authors.affiliation: Department of Pathology, Medical School, Xi'an Jiaotong University, Xi'an, 710061, China. dangxia75@163.com
authors.forename: Dang-Xia
authors.initials: DX
authors.lastname: Zhou
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Hai-Xu
authors.initials: HX
authors.lastname: Wang
authors.forename: Xiao-Fang
authors.initials: XF
authors.lastname: Wang
authors.forename: Zhao
authors.initials: Z
authors.lastname: Tian
authors.forename: Wen-Bao
authors.initials: WB
authors.lastname: Zhao
authors.forename: Shui-Ping
authors.initials: SP
authors.lastname: Han
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Yong-Wei
authors.initials: YW
authors.lastname: Huo
authors.forename: Hong
authors.initials: H
authors.lastname: Tian
mesh_terms: D002681:China / Q000453:epidemiology; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male
chemical_list: D015235:HLA-B Antigens