title: Cryotreatment against metastatic renal cell bone tumour reduced multiple lung metastases.
abstract: Metastatic renal cell carcinoma (RCC) has a poor response to anticancer chemotherapy and radiotherapy. While immunotherapy and molecular targeted drugs have been used as first-line therapy for RCC metastasis, the response rate to these agents is low. We report the case of a patient with lung and bone metastases of RCC whose lung metastases disappeared after reconstruction using the resected specimen treated by liquid nitrogen for the bone metastasis. This 60-year-old female had a left RCC with multiple lung metastases and a left femoral bone metastasis at the time of diagnosis. After left nephrectomy followed by immunotherapy, we performed tumour excision and reconstruction with frozen recycled autograft. The lung metastases had disappeared by 10 months after surgery, while serum levels of interferon-gamma and interleukin-12 had increased. We postulate that the antitumour activity resulted from immunotherapy plus cryotreatment of her bone metastasis and believe that this case supports continued research into immunotherapy for cancer.
authors.affiliation: Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University 13-1 Takara-machi, Kanazawa 920-8641, Japan. hideji0511@yahoo.co.jp
authors.forename: Hideji
authors.initials: H
authors.lastname: Nishida
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Shirai
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Hayashi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Takeuchi
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Tanzawa
authors.forename: Atsushi
authors.initials: A
authors.lastname: Mizokami
authors.forename: Mikio
authors.initials: M
authors.lastname: Namiki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsuchiya
mesh_terms: D002292:Carcinoma, Renal Cell / Q000473:pathology*; D017679:Cryotherapy; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology*; D008175:Lung Neoplasms / Q000532:radiotherapy / Q000556:secondary / Q000628:therapy*; D008875:Middle Aged; D014057:Tomography, X-Ray Computed