title: Four-year evaluation of the effect of vaccination against Coxiella burnetii on reduction of animal infection and environmental contamination in a naturally infected dairy sheep flock.
abstract: Vaccination is considered one of the best options for controlling Coxiella burnetii infection in livestock. The efficacy of a phase I vaccine was investigated over 4 years in a sheep flock with confirmed C. burnetii infection. Shedding was not detected in ewes and yearlings in the last 2 years, but C. burnetii still persisted in the environment.
authors.affiliation: NEIKER--Instituto Vasco de Investigación y Desarrollo Agrario, 48160 Derio, Bizkaia, Spain.
authors.forename: Ianire
authors.initials: I
authors.lastname: Astobiza
authors.forename: Jesús F
authors.initials: JF
authors.lastname: Barandika
authors.forename: Francisco
authors.initials: F
authors.lastname: Ruiz-Fons
authors.forename: Ana
authors.initials: A
authors.lastname: Hurtado
authors.forename: Inés
authors.initials: I
authors.lastname: Povedano
authors.forename: Ramón A
authors.initials: RA
authors.lastname: Juste
authors.forename: Ana L
authors.initials: AL
authors.lastname: García-Pérez
mesh_terms: D000818:Animals; D057138:Bacterial Shedding / Q000276:immunology; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D016997:Coxiella burnetii / Q000276:immunology / Q000302:isolation & purification*; D004783:Environmental Microbiology; D005500:Follow-Up Studies; D011778:Q Fever / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control*; D016896:Treatment Outcome; D014611:Vaccination / Q000379:methods; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology
chemical_list: D001428:Bacterial Vaccines; D015164:Vaccines, Inactivated