title: Novel peptide-specific quantitative structure-activity relationship (QSAR) analysis applied to collagen IV peptides with antiangiogenic activity.
abstract: Angiogenesis is the growth of new blood vessels from existing vasculature. Excessive vascularization is associated with a number of diseases including cancer. Antiangiogenic therapies have the potential to stunt cancer progression. Peptides derived from type IV collagen are potent inhibitors of angiogenesis. We wanted to gain a better understanding of collagen IV structure-activity relationships using a ligand-based approach. We developed novel peptide-specific QSAR models to study the activity of the peptides in endothelial cell proliferation, migration, and adhesion inhibition assays. We found that the models produced quantitatively accurate predictions of activity and provided insight into collagen IV derived peptide structure-activity relationships.
authors.affiliation: Department of Biomedical Engineering, 613 Traylor Building, Johns Hopkins University, 720 Rutland Avenue, Baltimore, Maryland 21205, United States. cgrivera@jhu.edu
authors.forename: Corban G
authors.initials: CG
authors.lastname: Rivera
authors.forename: Elena V
authors.initials: EV
authors.lastname: Rosca
authors.forename: Niranjan B
authors.initials: NB
authors.lastname: Pandey
authors.forename: Jacob E
authors.initials: JE
authors.lastname: Koskimaki
authors.forename: Joel S
authors.initials: JS
authors.lastname: Bader
authors.forename: Aleksander S
authors.initials: AS
authors.lastname: Popel
mesh_terms: D000465:Algorithms; D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D024141:Collagen Type IV / Q000737:chemistry*; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D018919:Neovascularization, Physiologic / Q000187:drug effects; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D021281:Quantitative Structure-Activity Relationship
chemical_list: D020533:Angiogenesis Inhibitors; D024141:Collagen Type IV; D008024:Ligands; D010455:Peptides