title: Cytotoxic nor-dammarane triterpenoids from Dysoxylum hainanense.
abstract: Four new nor-dammarane triterpenoids, 12β-O-acetyl-15α,28-dihydoxy-17β-methoxy-3-oxo-20,21,22-23,24,25,26,27-octanordammanran (1), 12β-O-acetyl-15α,17β,28-trihydoxy-3-oxo-20,21,22-23,24,25,26,27-octanordammanran (2), 12β-O-acetyl-15α,28-dihydoxy-3-oxo-17-en-20,21,22-23,24,25,26,27-octanordammanran (3), and 12β,15α,17β,28-tetrahydoxy-3-oxo-20,21,22-23,24,25,26,27-octanordammanran (4), were isolated from the 70% EtOH extract of Dysoxylum hainanense. The structures of the new compounds were elucidated by spectral methods. All the triterpenoids were in vitro evaluated for their cytotoxic activities against four tumor cell lines (A549, SK-OV-3, SKMEL-2 and HCT15).
authors.affiliation: The General Hospital of CAPF, #69 Yongding avenue, Haidian district, Beijin 100039, PR China.
authors.forename: Fan
authors.initials: F
authors.lastname: Wang
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Guan
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes