title: Dentine as a bioactive extracellular matrix.
abstract: As a mineralised connective tissue, dentine is well adapted to its functional role as a major structural component of the tooth. Although similar in composition to bone, dentine matrix is not remodelled physiologically and traditionally, has been regarded as a rather inert tissue. Nevertheless, dentine-pulp demonstrates strong regenerative potential which allows it to respond to disease and traumatic injury. Such responses are strongly influenced by cell-matrix interactions and modified by disease processes, including infection and inflammation. The identification of many bioactive molecules bound within dentine matrix has allowed their potential involvement in regenerative and other tissue responses to be better understood and new opportunities to be recognised for novel clinical therapies.
authors.affiliation: School of Dentistry, University of Birmingham, Birmingham, UK. a.j.smith@bham.ac.uk
authors.forename: A J
authors.initials: AJ
authors.lastname: Smith
authors.forename: B A
authors.initials: BA
authors.lastname: Scheven
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: J L
authors.initials: JL
authors.lastname: Ferracane
authors.forename: R M
authors.initials: RM
authors.lastname: Shelton
authors.forename: P R
authors.initials: PR
authors.lastname: Cooper
mesh_terms: D002450:Cell Communication; D016207:Cytokines / Q000502:physiology; D003782:Dental Pulp / Q000502:physiology*; D003804:Dentin / Q000502:physiology*; D005109:Extracellular Matrix / Q000502:physiology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D009479:Neuropeptides / Q000502:physiology; D009804:Odontoblasts / Q000502:physiology*; D012038:Regeneration
chemical_list: D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins; D009479:Neuropeptides