title: Frequent loss of the BLID gene in early-onset breast cancer.
abstract: The BH3-like motif-containing inducer of cell death (BLID) is an intronless gene localized on 11q24.1. Loss of that region has frequently been reported in early-onset breast cancer and is significantly associated with poor prognosis and reduced survival. Downregulation of BLID is associated with younger age, triple-negative phenotype, and reduced disease-free and overall survival of breast cancer patients. In this study, we investigated allelic loss of BLID in breast tumor specimens from 78 women with invasive breast cancer using 2 dinucleotide polymorphic markers closely linked to the BLID gene (no intragenic marker for BLID is available). Seventy-three cases were informative. Overall, loss of heterozygosity (LOH) at the BLID locus was detected in 32% of the informative cases (23/73). However, in patients 40 years old and younger, LOH was detected in 50% of the cases (9/18). Patients aged 40 years and younger were significantly more likely to experience LOH than those aged 41-55 years (p = 0.04). Specifically, the odds of BLID loss for patients aged 40 years and younger were 3.7 times the odds of loss for patients aged 41-55 years (95% CI, 1.1-13). Our findings suggest a tumor suppressor role of the BLID gene in early-onset breast cancer.
authors.affiliation: Department of Oncology, Georgetown University Medical Center, Washington, D.C., USA.
authors.forename: L R
authors.initials: LR
authors.lastname: Cavalli
authors.forename: A-M
authors.initials: AM
authors.lastname: Noone
authors.forename: K H
authors.initials: KH
authors.lastname: Makambi
authors.forename: J D
authors.initials: JD
authors.lastname: Rone
authors.forename: U N
authors.initials: UN
authors.lastname: Kasid
authors.forename: B R
authors.initials: BR
authors.lastname: Haddad
mesh_terms: D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D000483:Alleles; D051017:Apoptosis Regulatory Proteins / Q000172:deficiency / Q000235:genetics; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D002874:Chromosome Mapping / Q000379:methods*; D003582:Cytogenetics / Q000379:methods*; D017931:DNA Primers / Q000737:chemistry / Q000235:genetics; D015342:DNA Probes / Q000737:chemistry / Q000235:genetics; D004273:DNA, Neoplasm / Q000032:analysis* / Q000235:genetics; D005260:Female; D006801:Humans; D019656:Loss of Heterozygosity; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D016017:Odds Ratio; D011379:Prognosis; D012984:Software; D015996:Survival Rate
chemical_list: D051017:Apoptosis Regulatory Proteins; C118024:BLID protein, human; D014408:Biomarkers, Tumor; D017931:DNA Primers; D015342:DNA Probes; D004273:DNA, Neoplasm