title: Multisite carcinogenicity and respiratory toxicity of inhaled 1-bromopropane in rats and mice.
abstract: Two-year 1-bromopropane (1-BP) inhalation studies were conducted because of the potential for widespread exposure, the lack of chronic toxicity and carcinogenicity data, and the known carcinogenicity of structurally related compounds. Male and female F344/N rats and B6C3F1/N mice were exposed by inhalation to 0, 62.5 (mice only), 125, 250, or 500 (rats only) ppm 1-BP for 6 hr/day, 5 days/week for 105 weeks. Exposure of male and female rats to 1-BP resulted in significantly increased incidences of adenomas of the large intestine and skin neoplasms. In male rats, the incidence of malignant mesothelioma of the epididymis was statistically significantly increased at 500 ppm, but the biological significance of this common lesion is unclear. Incidences of pancreatic islet adenoma in male rats were significantly increased at all concentrations relative to concurrent controls but were within the historical control range for inhalation studies. There was no evidence of carcinogenic activity of 1-BP in male B6C3F1 mice; however, significantly increased incidences of alveolar/bronchiolar neoplasms of the lung were present in female mice. Exposure to 1-BP also resulted in increased incidences of nonneoplastic lesions in the nose of rats and mice, the larynx of rats and male mice, the trachea of female rats and male and female mice, and the lungs of mice. Inflammatory lesions with Splendore Hoeppli (S-H) material were present primarily in the nose and skin of exposed male and female rats, indicating that 1-BP caused immunosuppression.
authors.affiliation: National Institute of Environmental Health Sciences, National Toxicology Program, Research Triangle Park, North Carolina 27709, USA. morgan3@niehs.nih.gov
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Morgan
authors.forename: Abraham
authors.initials: A
authors.lastname: Nyska
authors.forename: Sam Jens
authors.initials: SJ
authors.lastname: Harbo
authors.forename: Sondra L
authors.initials: SL
authors.lastname: Grumbein
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Dill
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Roycroft
authors.forename: Grace E
authors.initials: GE
authors.lastname: Kissling
authors.forename: Mark F
authors.initials: MF
authors.lastname: Cesta
mesh_terms: D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000139:chemically induced; D000818:Animals; D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D005260:Female; D006842:Hydrocarbons, Brominated / Q000633:toxicity; D007165:Immunosuppression Therapy; D019570:Inhalation Exposure; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000139:chemically induced; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D002273:Carcinogens; D006842:Hydrocarbons, Brominated; C118559:1-bromopropane