title: Short review on sublingual immunotherapy for patients with allergic rhinitis: from bench to bedside.
abstract: Sublingual immunotherapy has been considered to be a painless and effective therapeutic treatment for allergic rhinitis, and is known as type 1 allergy of the nasal mucosa. So far, its mechanism of action has been elucidated employing peripheral blood serum and lymphocytes in an antigen-specific fashion. Because of the limitations in sampling human materials, there is still controversy among many reports between clinical efficacy and laboratory data. Therefore, its mechanism of action needs to be investigated further by using promising animal models such as rodents and monkeys. Bearing this in mind, in our present study, we successfully constructed an effective murine model for sublingual immunotherapy in allergic rhinitis in which mice were administered ovalbumin (OVA) sublingually followed by intraperitoneal sensitization and nasal challenge.
authors.affiliation: Department of Otorhinolaryngology, Shimane University, Faculty of Medicine, Izumo, Japan. kawauchi@med.shimane-u.ac.jp
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Kawauchi
authors.forename: Kaoru
authors.initials: K
authors.lastname: Goda
authors.forename: Miki
authors.initials: M
authors.lastname: Tongu
authors.forename: Takaya
authors.initials: T
authors.lastname: Yamada
authors.forename: Noriaki
authors.initials: N
authors.lastname: Aoi
authors.forename: Ichiro
authors.initials: I
authors.lastname: Morikura
authors.forename: Takashi
authors.initials: T
authors.lastname: Fuchiwaki
mesh_terms: D000286:Administration, Sublingual; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D009297:Nasal Mucosa / Q000276:immunology*; D010047:Ovalbumin / Q000008:administration & dosage*; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D010047:Ovalbumin