title: All is fair in virus-host interactions: NK cells and cytomegalovirus.
abstract: The infection of mice with mouse cytomegalovirus (MCMV) as a model of human cytomegalovirus (HCMV) infection has been particularly informative in elucidating the role of innate and adaptive immune response mechanisms during infection. Millions of years of co-evolution between cytomegaloviruses (CMV) and their hosts has resulted in numerous attempts to overwhelm each other. CMVs devote many genes to modulating the host natural killer (NK) cell response and NK cells employ many strategies to cope with CMV infection. While focusing on these attack-counterattack measures, this review will discuss several novel mechanisms of immune evasion by MCMV, the role of Ly49 receptors in mediating resistance to MCMV, and the impact of the initial NK cell response on the shaping of adaptive immunity.
authors.affiliation: Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, B. Branchetta 20, 51 000 Rijeka, Croatia.
authors.forename: Marina
authors.initials: M
authors.lastname: Babić
authors.forename: Astrid
authors.initials: A
authors.lastname: Krmpotić
authors.forename: Stipan
authors.initials: S
authors.lastname: Jonjić
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D003587:Cytomegalovirus / Q000502:physiology*; D003586:Cytomegalovirus Infections / Q000276:immunology / Q000473:pathology / Q000821:virology*; D004195:Disease Models, Animal; D006801:Humans; D057131:Immune Evasion; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism*; D055650:NK Cell Lectin-Like Receptor Subfamily A / Q000378:metabolism; D055655:NK Cell Lectin-Like Receptor Subfamily K / Q000378:metabolism
chemical_list: C527085:KLRK1 protein, human; D055650:NK Cell Lectin-Like Receptor Subfamily A; D055655:NK Cell Lectin-Like Receptor Subfamily K