title: MicroRNA function in the nervous system.
abstract: MicroRNAs (miRNAs) are an extensive class of small noncoding RNAs that control posttranscriptional gene expression. miRNAs are highly expressed in neurons where they play key roles during neuronal differentiation, synaptogenesis, and plasticity. It is also becoming increasingly evident that miRNAs have a profound impact on higher cognitive functions and are involved in the etiology of several neurological diseases and disorders. In this chapter, we summarize our current knowledge of miRNA functions during neuronal development, physiology, and dysfunction.
authors.affiliation: Interdisziplinäres Zentrum für Neurowissenschaften, SFB488 Junior Group, Universität Heidelberg, and Institut für Neuroanatomie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 345, Heidelberg, Germany.
authors.forename: Roberto
authors.initials: R
authors.lastname: Fiore
authors.forename: Sharof
authors.initials: S
authors.lastname: Khudayberdiev
authors.forename: Reuben
authors.initials: R
authors.lastname: Saba
authors.forename: Gerhard
authors.initials: G
authors.lastname: Schratt
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D008938:Mitosis / Q000235:genetics; D009420:Nervous System / Q000254:growth & development / Q000378:metabolism*; D009422:Nervous System Diseases / Q000235:genetics; D009474:Neurons / Q000166:cytology / Q000378:metabolism
chemical_list: D035683:MicroRNAs