title: Fetopathologic examination for early termination of pregnancy: dogma or necessity?
abstract: OBJECTIVE
  Our objective was assessment of fetopathological examination after termination of pregnancy (TOP) for fetal anomalies with normal karyotype <17 weeks of gestation.
  
  
  METHODS
  This was a multicenter retrospective study. Records of TOP for fetal anomalies with normal karyotype were analyzed. Primary outcomes were modifications of genetic counseling and management of next subsequent pregnancies. Medical TOPs were compared with surgical TOPs.
  
  
  RESULTS
  In all, 59 pregnancies were included (30 aspirations, 29 inductions). Fetopathological examination modified genetic counseling for 22 patients: 62% for the medical induction group vs 13% in the vacuum aspiration group (P < .001). Management of subsequent pregnancies was modified in 17% in the medical induction group vs 3% in the aspiration group (P = .06).
  
  
  CONCLUSIONS
  Fetopathological examination for early TOP with normal karyotype is relevant, especially when an intact fetus is examined. Thanks to it, genetic counseling is often modified, as is management of the next pregnancy. Medical procedures should be preferred to surgical procedures.
authors.affiliation: Department of Obstetrics and Gynecology, Cochin University Hospital, Paris Descartes University, Paris, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Gitz
authors.forename: Suonavy
authors.initials: S
authors.lastname: Khung-Savatovsky
authors.forename: Géraldine
authors.initials: G
authors.lastname: Viot
authors.forename: Julia
authors.initials: J
authors.lastname: Tantau
authors.forename: Gilles
authors.initials: G
authors.lastname: Grangé
authors.forename: Fanny
authors.initials: F
authors.lastname: Lewin
authors.forename: Anne-Lise
authors.initials: AL
authors.lastname: Delezoide
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Oury
authors.forename: Vassilis
authors.initials: V
authors.lastname: Tsatsaris
mesh_terms: D000028:Abortion, Induced; D000328:Adult; D000013:Congenital Abnormalities / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D005333:Fetus / Q000473:pathology*; D005817:Genetic Counseling; D006801:Humans; D059785:Karyotype; D011247:Pregnancy; D012189:Retrospective Studies; D014463:Ultrasonography