title: Treating Clostridium difficile infection with fecal microbiota transplantation.
abstract: Clostridium difficile infection is increasing in incidence, severity, and mortality. Treatment options are limited and appear to be losing efficacy. Recurrent disease is especially challenging; extended treatment with oral vancomycin is becoming increasingly common but is expensive. Fecal microbiota transplantation is safe, inexpensive, and effective; according to case and small series reports, about 90% of patients are cured. We discuss the rationale, methods, and use of fecal microbiota transplantation.
authors.affiliation: St Luke's Infectious Disease Associates, Duluth, Minnesota, USA.
authors.forename: Johan S
authors.initials: JS
authors.lastname: Bakken
authors.forename: Thomas
authors.initials: T
authors.lastname: Borody
authors.forename: Lawrence J
authors.initials: LJ
authors.lastname: Brandt
authors.forename: Joel V
authors.initials: JV
authors.lastname: Brill
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Demarco
authors.forename: Marc Alaric
authors.initials: MA
authors.lastname: Franzos
authors.forename: Colleen
authors.initials: C
authors.lastname: Kelly
authors.forename: Alexander
authors.initials: A
authors.lastname: Khoruts
authors.forename: Thomas
authors.initials: T
authors.lastname: Louie
authors.forename: Lawrence P
authors.initials: LP
authors.lastname: Martinelli
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Moore
authors.forename: George
authors.initials: G
authors.lastname: Russell
authors.forename: Christina
authors.initials: C
authors.lastname: Surawicz
mesh_terms: D016360:Clostridioides difficile / Q000302:isolation & purification*; D003015:Clostridium Infections / Q000628:therapy*; D005243:Feces / Q000382:microbiology*; D006801:Humans; D019936:Probiotics / Q000008:administration & dosage*; D016896:Treatment Outcome