title: Uncaria tomentosa for Reducing Side Effects Caused by Chemotherapy in CRC Patients: Clinical Trial.
abstract: To evaluate the effectiveness of Uncaria tomentosa in minimizing the side effects of chemotherapy and improving the antioxidant status of colorectal cancer (CRC) patients, a randomized clinical trial was conducted. Patients (43) undergoing adjuvant/palliative chemotherapy with 5-Fluorouracil/leucovorin + oxaliplatin (FOLFOX4) were split into two groups: the UT group received chemotherapy plus 300 mg of Uncaria tomentosa daily and the C group received only FOLFOX4 and served as a control. Blood samples were collected before each of the 6 cycles of chemotherapy, and hemograms, oxidative stress, enzymes antioxidants, immunologic parameters, and adverse events were analyzed. The use of 300 mg of Uncaria tomentosa daily during 6 cycles of FOLFOX4 did not change the analyzed parameters, and no toxic effects were observed.
authors.affiliation: Departamento de Química, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil.
authors.forename: I L G
authors.initials: IL
authors.lastname: Farias
authors.forename: M C S
authors.initials: MC
authors.lastname: Araújo
authors.forename: J G
authors.initials: JG
authors.lastname: Farias
authors.forename: L V
authors.initials: LV
authors.lastname: Rossato
authors.forename: L I
authors.initials: LI
authors.lastname: Elsenbach
authors.forename: S L
authors.initials: SL
authors.lastname: Dalmora
authors.forename: N M P
authors.initials: NM
authors.lastname: Flores
authors.forename: M
authors.initials: M
authors.lastname: Durigon
authors.forename: I B M
authors.initials: IB
authors.lastname: Cruz
authors.forename: V M
authors.initials: VM
authors.lastname: Morsch
authors.forename: M R C
authors.initials: MR
authors.lastname: Schetinger