title: Age-associated alteration in innate immune response in captive baboons.
abstract: Baboons are an ideal model for studies of human inflammatory response due to their physiological and immunological similarities to people; however; little is known about how age affects immune function in the baboon. We sought to determine if baboons show age-related innate immune changes similar to that described in people. Age was correlated with increased serum C-reactive protein and interleukin-6 or, however, no change in interleukin-10 concentration was observed (n = 120 baboons). Cytokine release from unstimulated peripheral blood mononuclear cells as well as following immune (lipopolysaccharide) stimulation increased with age. When whole blood was assayed, both lipopolysaccharide stimulated and unstimulated samples showed an age-related increase in interleukin-6 response, although the unstimulated cytokine response was reduced compared with that observed in peripheral blood mononuclear cells. Tumor necrosis factor-α response was not related to age. Cytokine response in lipopolysaccharide-stimulated whole blood was negatively correlated with serum DHEA-S concentration and positively correlated with TGF-β concentration.
authors.affiliation: Department of Physiological Sciences, Center of Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USA. diannem@okstate.edu
authors.forename: Dianne
authors.initials: D
authors.lastname: McFarlane
authors.forename: Roman F
authors.initials: RF
authors.lastname: Wolf
authors.forename: Kristen A
authors.initials: KA
authors.lastname: McDaniel
authors.forename: Gary L
authors.initials: GL
authors.lastname: White
mesh_terms: D000375:Aging / Q000097:blood / Q000276:immunology*; D000818:Animals; D002097:C-Reactive Protein / Q000378:metabolism; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D005260:Female; D006801:Humans; D007113:Immunity, Innate; D066298:In Vitro Techniques; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D023421:Models, Animal; D048529:Papio hamadryas / Q000097:blood / Q000276:immunology*; D013045:Species Specificity; D016212:Transforming Growth Factor beta / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015850:Interleukin-6; D008070:Lipopolysaccharides; D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D019314:Dehydroepiandrosterone Sulfate; D002097:C-Reactive Protein