title: Low concordance between positive antibodies to thyroperoxidase and thyroid ultrasound autoimmune pattern in pregnant women.
abstract: The diagnostic and prognostic role of thyroid ultrasound (TUS) in pregnant women positive for antibodies to thyroperoxidase (TPOAb) is unclear.  The aim of our study was to compare the relation of ultrasound thyroid texture to the thyroid laboratory tests in pregnant women and controls.  Using a semi-quantitative assessment we compared TUS in two groups of women with positive TPOAb and/or with thyroid dysfunction (TSH out of 0.06-3.67 mIU/L): 186 women in 1(st) trimester of pregnancy recruited from universal screening and 67 asymptomatic age-comparable non-pregnant non-postpartum women recruited from screening of general population (controls).  Women with previous history of thyroid diseases were excluded.  Only 64/131 (48.9 %) of TPOAb-positive pregnant women were TUS-positive (TUS with autoimmune pattern) in comparison with 35/49 (71.4 %) TPOAb-positive controls (p <0.011).  Pregnant women had more often TSH >10.0 mIU/L if they were TPOAb-positive/TUS-positive as compared to those TPOAb-positive/TUS-negative (8/64 (12.5 %) vs. 0/67 (0 %), p = 0.009).  The prevalence of preterm deliveries among TPOAb-positive women was significantly lower if TPOAb-positivity was not accompanied by TUS-positivity (2/67 (3.0 %) vs. 10/64 (15.6 %) in TPOAb-positive/TUS-positive women, p = 0.028).  In conclusion, nearly half of the TPOAb-positive pregnant women did not have an autoimmune pattern in TUS.  Normal TUS image in TPOAb-positive pregnant women might be a protective factor for preterm delivery.
authors.affiliation: 3rd Department of Medicine, 1st Faculty of Medicine, Charles University, General University Hospital, Prague, Czech Republic. jan.jiskra@vfn.cz
authors.forename: Jan
authors.initials: J
authors.lastname: Jiskra
authors.forename: Jana
authors.initials: J
authors.lastname: Bartáková
authors.forename: Štěpán
authors.initials: Š
authors.lastname: Holinka
authors.forename: Zdeňka
authors.initials: Z
authors.lastname: Límanová
authors.forename: Drahomíra
authors.initials: D
authors.lastname: Springer
authors.forename: Tomáš
authors.initials: T
authors.lastname: Fait
authors.forename: Marie
authors.initials: M
authors.lastname: Antošová
authors.forename: Zdeněk
authors.initials: Z
authors.lastname: Telička
authors.forename: Eliška
authors.initials: E
authors.lastname: Potluková
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D001324:Autoantigens / Q000378:metabolism; D018153:Czech Republic / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007453:Iodide Peroxidase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D033862:Iron-Binding Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008403:Mass Screening / Q000379:methods; D009929:Organ Size; D011247:Pregnancy; D011248:Pregnancy Complications / Q000000981:diagnostic imaging / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D011252:Pregnancy Complications, Neoplastic / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D047928:Premature Birth / Q000453:epidemiology / Q000209:etiology; D015995:Prevalence; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013961:Thyroid Gland / Q000000981:diagnostic imaging* / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D016606:Thyroid Nodule / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D013967:Thyroiditis, Autoimmune / Q000000981:diagnostic imaging* / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D013972:Thyrotropin / Q000097:blood; D014463:Ultrasonography
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D033862:Iron-Binding Proteins; D013972:Thyrotropin; C056658:TPO protein, human; D007453:Iodide Peroxidase