title: Development of a method for environmentally friendly chemical peptide synthesis in water using water-dispersible amino acid nanoparticles.
abstract: Due to the vast importance of peptides in biological processes, there is an escalating need for synthetic peptides to be used in a wide variety of applications. However, the consumption of organic solvent is extremely large in chemical peptide syntheses because of the multiple condensation steps in organic solvents. That is, the current synthesis method is not environmentally friendly. From the viewpoint of green sustainable chemistry, we focused on developing an organic solvent-free synthetic method using water, an environmentally friendly solvent. Here we described in-water synthesis technology using water-dispersible protected amino acids.
authors.affiliation: Faculty of Pharmaceutical Sciences & Cooperative Research Center of Life Sciences, Kobe Gakuin University, Chuo-ku, Kobe 650-8586, Japan. hojo@pharm.kobegakuin.ac.jp.
authors.forename: Keiko
authors.initials: K
authors.lastname: Hojo
authors.forename: Asaki
authors.initials: A
authors.lastname: Hara
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kitai
authors.forename: Mare
authors.initials: M
authors.lastname: Onishi
authors.forename: Hideki
authors.initials: H
authors.lastname: Ichikawa
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Fukumori
authors.forename: Koichi
authors.initials: K
authors.lastname: Kawasaki