title: Dual-mode IVUS transducer for image-guided brain therapy: preliminary experiments.
abstract: In this study, we investigated the feasibility of using 3.5-Fr intravascular ultrasound (IVUS) catheters for minimally-invasive, image-guided hyperthermia treatment of tumors in the brain. Feasibility was demonstrated by: (1) retro-fitting a commercial 3.5-Fr IVUS catheter with a 5 × 0.5 × 0.22 mm PZT-4 transducer for 9-MHz imaging and (2) testing an identical transducer for therapy potential with 3.3-MHz continuous-wave excitation. The imaging transducer was compared with a 9-Fr, 9-MHz ICE catheter when visualizing the post-mortem ovine brain and was also used to attempt vascular access to an in vivo porcine brain. A net average electrical power input of 700 mW was applied to the therapy transducer, producing a temperature rise of +13.5°C at a depth of 1.5 mm in live brain tumor tissue in the mouse model. These results suggest that it may be feasible to combine the imaging and therapeutic capabilities into a single device as a clinically-viable instrument.
authors.affiliation: Department of Biomedical Engineering, Duke University Medical Center, Durham, NC 27708, USA. cdh14@duke.edu
authors.forename: Carl D
authors.initials: CD
authors.lastname: Herickhoff
authors.forename: Christy M
authors.initials: CM
authors.lastname: Wilson
authors.forename: Gerald A
authors.initials: GA
authors.lastname: Grant
authors.forename: Gavin W
authors.initials: GW
authors.lastname: Britz
authors.forename: Edward D
authors.initials: ED
authors.lastname: Light
authors.forename: Mark L
authors.initials: ML
authors.lastname: Palmeri
authors.forename: Patrick D
authors.initials: PD
authors.lastname: Wolf
authors.forename: Stephen W
authors.initials: SW
authors.lastname: Smith
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000628:therapy*; D002533:Cerebral Angiography; D004195:Disease Models, Animal; D004867:Equipment Design; D005240:Feasibility Studies; D005909:Glioblastoma / Q000628:therapy*; D006979:Hyperthermia, Induced / Q000295:instrumentation*; D051379:Mice; D008819:Mice, Nude; D019047:Phantoms, Imaging; D034561:Sheep, Domestic; D025321:Surgery, Computer-Assisted / Q000295:instrumentation*; D013552:Swine; D014159:Transducers; D018084:Ultrasonography, Interventional / Q000295:instrumentation*