title: 17-O-acetyl,10-hydroxycorynantheol, a selective antiplasmodial alkaloid isolated from Strychnos usambarensis leaves.
abstract: In the course of our investigations on Strychnos usambarensis leaves in order to isolate isostrychnopentamine, the main alkaloid responsible for the antiplasmodial activity of the plant, a new tertiary indolic alkaloid has been isolated: 17-O-acetyl,10-hydroxycorynantheol 1. Its structure was determined by means of spectroscopic and spectrometric methods such as UV, IR, CD, NMR, and ESI-MS. 17-O-acetyl,10-hydroxycorynantheol 1 is one of the most active monomeric indole alkaloids known to date showing an in vitro activity against Plasmodium falciparum close to 5 µM and a high selectivity.
authors.affiliation: Laboratory of Pharmacognosy, Drug Research Center (CIRM), University of Liège, Liège, Belgium. Martine.Cao@ulg.ac.be
authors.forename: Martine
authors.initials: M
authors.lastname: Cao
authors.forename: Raymond
authors.initials: R
authors.lastname: Muganga
authors.forename: Monique
authors.initials: M
authors.lastname: Tits
authors.forename: Luc
authors.initials: L
authors.lastname: Angenot
authors.forename: Michel
authors.initials: M
authors.lastname: Frédérich
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002942:Circular Dichroism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry / Q000379:methods; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D018515:Plant Leaves / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D013237:Stereoisomerism; D031451:Strychnos / Q000737:chemistry*
chemical_list: C571325:17-O-acetyl,10-hydroxycorynantheol; D000470:Alkaloids; D000962:Antimalarials