title: Synthesis, spectroscopic, antimicrobial, DNA binding and cleavage studies of some metal complexes involving symmetrical bidentate N, N donor Schiff base ligand.
abstract: The Schiff base ligand, N,N'-bis-(4-isopropylbenzaldimine)-1,2-diaminoethane (L), obtained by the condensation of 4-isopropylbenzaldehyde and 1,2-diaminoethane, has been used to synthesize the complexes of the type [ML(2)X(2)] [M = Co(II), Ni(II) and Zn(II); X = Cl and OAc]. The newly synthesized ligand (L) and its complexes have been characterized on the basis of elemental analyses, mass, (1)H and (13)C-NMR, molar conductance, IR, UV-vis, magnetic moment, CV and thermal analyses, powder XRD and SEM. IR spectral data show that the ligand is coordinated to the metal ions in a bidentate manner. The geometrical structures of these complexes are found to be octahedral. Interestingly, reaction with Cu(II) ion with this ligand undergoes hydrolytic cleavage to form ethylenediamine copper(II) complex and the corresponding aldehyde. The antimicrobial results indicate that the chloro complexes exhibit more activity than the acetato complexes. The complexes bind to CT-DNA by intercalation modes. Novel chloroform soluble ZnL(2)Cl(2) complex exhibits tremendous antimicrobial, DNA binding and cleaving properties.
authors.affiliation: Department of Chemistry, Manonmaniam Sundaranar University, Tirunelveli 627 012, India.
authors.forename: D
authors.initials: D
authors.lastname: Arish
authors.forename: M Sivasankaran
authors.initials: MS
authors.lastname: Nair
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry*; D002713:Chlorine / Q000737:chemistry; D002725:Chloroform / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D004563:Electrochemistry / Q000379:methods; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008855:Microscopy, Electron, Scanning / Q000379:methods; D008956:Models, Chemical; D011485:Protein Binding; D012545:Schiff Bases / Q000737:chemistry*; D012995:Solubility; D013053:Spectrophotometry / Q000379:methods*; D013055:Spectrophotometry, Infrared / Q000379:methods; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D014961:X-Ray Diffraction / Q000379:methods
chemical_list: D000890:Anti-Infective Agents; D008024:Ligands; D012545:Schiff Bases; D002713:Chlorine; D002725:Chloroform; D004247:DNA