title: Distribution of white matter hyperintensity in cerebral hemorrhage and healthy aging.
abstract: We compared the severity of white matter T2-hyperintensities (WMH) in the frontal lobe and occipital lobe using a visual MRI score in 102 patients with lobar intracerebral hemorrhage (ICH) diagnosed with possible or probable cerebral amyloid angiopathy (CAA), 99 patients with hypertension-related deep ICH, and 159 normal elderly subjects from a population-based cohort. The frontal-occipital (FO) gradient was used to describe the difference in the severity of WMH between the frontal lobe and occipital lobe. A higher proportion of subjects with obvious occipital dominant WMH (FO gradient ≤-2) was found among patients with lobar ICH than among healthy elderly subjects (FO gradient ≤-2: 13.7 vs. 5.7%, p = 0.03). Subjects with obvious occipital dominant WMH were more likely to have more WMH (p = 0.0006) and a significantly higher prevalence of the apolipoprotein E ε4 allele (45.8% vs. 19.4%, p = 0.04) than those who had obvious frontal dominant WMH. This finding is consistent with the relative predilection of CAA for posterior brain regions, and suggests that white matter lesions may preferentially occur in areas of greatest vascular pathology.
authors.affiliation: Department of Neurology, Peking Union Medical College Hospital, Beijing, China.
authors.forename: Yi-Cheng
authors.initials: YC
authors.lastname: Zhu
authors.forename: Hugues
authors.initials: H
authors.lastname: Chabriat
authors.forename: Ophélia
authors.initials: O
authors.lastname: Godin
authors.forename: Carole
authors.initials: C
authors.lastname: Dufouil
authors.forename: Jonathan
authors.initials: J
authors.lastname: Rosand
authors.forename: Steven M
authors.initials: SM
authors.lastname: Greenberg
authors.forename: Eric E
authors.initials: EE
authors.lastname: Smith
authors.forename: Christophe
authors.initials: C
authors.lastname: Tzourio
authors.forename: Anand
authors.initials: A
authors.lastname: Viswanathan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D016657:Cerebral Amyloid Angiopathy / Q000209:etiology; D002543:Cerebral Hemorrhage / Q000150:complications* / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D056784:Leukoencephalopathies / Q000209:etiology* / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012189:Retrospective Studies