title: Keloids: prevention and management.
abstract: Keloids result from an abnormal wound-healing process in which the normal regulatory pathways during tissue regeneration and scar remodeling are disrupted. While the pathogenesis of keloids continues to be investigated, numerous treatment options exist. Although prevention of keloid formation is the best management, early recognition of keloid formation is integral in treatment and prevention of recurrence. Surgical resection with adjuvant silicone gel sheeting or triamcinolone injection is common, but can still result in recurrence. New treatments include chemotherapeutics such as 5-fluorouracil, bleomycin, and mitomycin C. Although further clinical investigation is required for newer treatments, initial results are promising.
authors.affiliation: Division of Facial Plastic Surgery, Department of Otolaryngology-Head and Neck Surgery, Northwestern University Feinberg School of Medicine, 676 North Street Clair, Suite 1325, Chicago, IL 60611, USA. drsidle@yahoo.com
authors.forename: Douglas M
authors.initials: DM
authors.lastname: Sidle
authors.forename: Haena
authors.initials: H
authors.lastname: Kim
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D058128:Compression Bandages; D003879:Dermatologic Agents / Q000627:therapeutic use; D006801:Humans; D007627:Keloid / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control / Q000628:therapy*; D011878:Radiotherapy; D019651:Plastic Surgery Procedures
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D003879:Dermatologic Agents