title: Population genetic analyses of the AmpFlSTR® NGM™ in Brazil.
abstract: Population data of 15 short tandem repeat loci of the AmpFlSTR® next generation multiplex (NGM)™ were obtained from a sample of 835 individuals. The loci are the ten short tandem repeats (STRs) in the SGM Plus® Kit plus the EDNAP- and ENSFI-recommended STRs D10S1248, D22S1045, D2S441, D1S1656, and D12S391. Allele frequency and other forensically relevant statistics data were generated for the NGM loci into five current country macroregions of Brazil (North, Northeast, Central West, Southeast, and South). All the analyzed loci meet Hardy-Weinberg equilibrium expectations and no linkage disequilibrium in all pairs of loci. The observed and expected heterozygosity, power of discrimination, polymorphic information content, and the other population-genetic indices were calculated. The overall power of discrimination was greater than 0.99999999999999999996 and the combined power of exclusion was greater than 0.9999998 in all Brazilian populations. Comparative analysis between populations from different Brazilian macroregions as well as between Brazil and Caucasian, African Americans, and Hispanic US populations are presented.
authors.affiliation: Life Technologies do Brasil, Av do Café, 277 1° andar Bloco A, 04311-000, São Paulo, SP, Brazil.
authors.forename: Paulo Eduardo
authors.initials: PE
authors.lastname: Raimann
authors.forename: Gabriela
authors.initials: G
authors.lastname: Hirschfeld-Campolongo
authors.forename: Simone
authors.initials: S
authors.lastname: Schumacher
authors.forename: Sabrina Esteves
authors.initials: SE
authors.lastname: de Mattos Almeida
authors.forename: Cláudia Maria Dornelles
authors.initials: CM
authors.lastname: da Silva
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Rodenbusch
authors.forename: Alessandra Simões
authors.initials: AS
authors.lastname: Bassini
authors.forename: Leandro Fonseca
authors.initials: LF
authors.lastname: de Souza
authors.forename: Eugênio César Soares
authors.initials: EC
authors.lastname: Nascimento
authors.forename: Eleusa Santana
authors.initials: ES
authors.lastname: de Oliveira
authors.forename: Valéria Rosalina Dias E
authors.initials: VR
authors.lastname: Santos
authors.forename: Elza Cristina Lopes
authors.initials: EC
authors.lastname: de Oliveira
authors.forename: Eloísa Aurora
authors.initials: EA
authors.lastname: Auler-Bittencourt
authors.forename: Roberta Casemiro
authors.initials: RC
authors.lastname: da Rocha Hirschfeld-Campolongo
authors.forename: Maria Luiza Almeida Prado Oliveira
authors.initials: ML
authors.lastname: E Sousa
authors.forename: Helder Pereira
authors.initials: HP
authors.lastname: de Figueiredo
authors.forename: Bruno Boiko Pereira
authors.initials: BB
authors.lastname: de Figueiredo
authors.forename: Rosane
authors.initials: R
authors.lastname: Silva
authors.forename: Rodrigo Soares
authors.initials: RS
authors.lastname: Moura-Neto
mesh_terms: D001741:Black or African American / Q000235:genetics*; D001938:Brazil; D005787:Gene Frequency; D008040:Genetic Linkage; D005828:Genetics, Population; D006630:Hispanic or Latino / Q000235:genetics*; D006801:Humans; D018895:Microsatellite Repeats; D044465:White People / Q000235:genetics*