title: Expression of IGF-1 and IGF-1R and their relation to clinicopathological factors in colorectal cancer.
abstract: BACKGROUND
  Expression of insulin-like growth factor-1 (IGF-1) and IGF-1 receptor (IGF-1R) has been shown to increase in colorectal cancer. We examined the correlation between expression of IGF-1 and IGF-1R and clinicopathological factors in colorectal cancer.
  
  
  METHODS
  A prospective study was conducted of 210 colorectal cancer patients that underwent resection from January 2002 to December 2004. The clinicopathological data was correlated to expression of IGF-1 and IGF-1R obtained from immunohistochemical analysis. Statistical analysis was carried using univariate and multivariate analysis.
  
  
  RESULTS
  IGF1 and IGF-1R staining was positive in 169 (80%) and 139 (66%) cases, respectively. Univariate and multivariate analyses showed significant correlation between expression of IGF-1 and tumor size (p=0.0024), and depth of invasion (p=0.0147). While IGF-1R was significantly correlated to tumor size and depth of invasion in univariate analysis, only tumor size (p=0.0658) had a strong association in multivariate analysis.
  
  
  CONCLUSIONS
  Expression of IGF-1 and IGF-1R seems to increase with tumor size in colorectal cancer.
authors.affiliation: Department of Surgery, Faculty of Medicine, Kurume University, 67 Asahi-machi, Kurume, Fukuoka 830-0011, Japan. ichitaro1217@yahoo.co.jp
authors.forename: Ichitarou
authors.initials: I
authors.lastname: Shiratsuchi
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Akagi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kawahara
authors.forename: Tetsushi
authors.initials: T
authors.lastname: Kinugasa
authors.forename: Kansakar
authors.initials: K
authors.lastname: Romeo
authors.forename: Takefumi
authors.initials: T
authors.lastname: Yoshida
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Ryu
authors.forename: Yukito
authors.initials: Y
authors.lastname: Gotanda
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kage
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shirouzu
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D011446:Prospective Studies; D017526:Receptor, IGF Type 1 / Q000096:biosynthesis* / Q000235:genetics; D047368:Tumor Burden
chemical_list: D009363:Neoplasm Proteins; D007334:Insulin-Like Growth Factor I; D017526:Receptor, IGF Type 1