title: The potential role of radiation therapy in Bowen's disease: a review of the current literature.
abstract: BACKGROUND
  Bowen's disease is a form of squamous cell carcinoma in situ that can be transformed into invasive squamous cell carcinoma and should be treated according to its anatomical position. The aim of this article is to offer an overview of treatment options with an emphasis on radiation therapy in the treatment of Bowen's disease.
  
  
  METHODS
  We performed overview of the literature based on database searches in PubMed/MEDLINE and we included articles till December 2010. Only papers published in English were included.
  
  
  RESULTS
  There was no standard fractionation regimen: some physicians prescribed high doses, such as the ones of invasive skin cancer, whereas others prescribed lower doses because of the noninvasive nature of the disease, the sensitive anatomic location (e.g., extremity) and the large treatment area. Various studies demonstrate high rates of tumor control with minimal morbidity following definitive radiation therapy in the treatment of Bowen's Disease. Through a multidisciplinary assessment, the treatment of Bowen's disease can be individualized to optimize patient care.
  
  
  CONCLUSIONS
  Radiation therapy is an effective treatment option for Bowen's disease of the skin. Local recurrences seem to be equally low in patients treated with high- and low-dose regimens. Radiotherapy preserves normal tissues ensuring a superior esthetic and functional outcome.
authors.affiliation: Kapodistrian University of Athens, Medical School, 1st Radiology Department, Aretaieion Hospital, Agiou Antoniou 45, Barimpobi, Attiki, Greece, PC 13477. annazygo1@yahoo.gr
authors.forename: Zygogianni
authors.initials: Z
authors.lastname: Anna
authors.forename: Kouvaris
authors.initials: K
authors.lastname: John
authors.forename: Tolia
authors.initials: T
authors.lastname: Maria
authors.forename: Kyrgias
authors.initials: K
authors.lastname: George
authors.forename: Beli
authors.initials: B
authors.lastname: Ivelina
authors.forename: Kantzou
authors.initials: K
authors.lastname: Ioanna
authors.forename: Soulimioti
authors.initials: S
authors.lastname: Georgia
authors.forename: Kouloulias
authors.initials: K
authors.lastname: Vassilis
mesh_terms: D001913:Bowen's Disease / Q000532:radiotherapy*; D006801:Humans; D012878:Skin Neoplasms / Q000532:radiotherapy*