title: Prenatal exposure to bisphenol A and phthalates and infant neurobehavior.
abstract: OBJECTIVE
  To examine the association of prenatal exposure to bisphenol A and select common phthalates with infant neurobehavior measured at 5 weeks.
  
  
  METHODS
  We compared the concentration of maternal urinary metabolites of bisphenol A and phthalates at two distinct time points in pregnancy (16w, 26w) with scores on the NICU Network Neurobehavioral Scale (NNNS) at 5 weeks of age in a cohort of 350 mother/infant pairs.
  
  
  RESULTS
  Prenatal exposure to BPA was not significantly associated with neurobehavioral outcomes at 5 weeks. Significant associations between prenatal exposure to measured phthalates and infant neurobehavioral outcomes differed by type of phthalate and were only seen with exposure measured at 26 weeks. Higher total di-butyl phthalate (DBP) metabolites at 26w were associated with improved behavioral organization evidenced by decreased arousal (p=.04), increased self-regulation (p=.052), and decreased handling (p=.02). In males, higher total di-2-ethylhexyl phthalate (DEHP) metabolites at 26w were associated with more nonoptimal reflexes (p=.02).
  
  
  CONCLUSIONS
  The association between prenatal phthalate exposure and infant neurobehavior differed by type of phthalate and was evident only with exposure measured at 26w. Prenatal exposure to DBP was associated with improved behavioral organization in 5-week-old infants. Prenatal exposure to DEHP was associated with nonoptimal reflexes in male infants. There was no evidence of an association between prenatal BPA exposure and infant neurobehavior.
authors.affiliation: Department of Pediatrics, Division of General and Community Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, United States. kimberly.yolton@cchmc.org
authors.forename: Kimberly
authors.initials: K
authors.lastname: Yolton
authors.forename: Yingying
authors.initials: Y
authors.lastname: Xu
authors.forename: Donna
authors.initials: D
authors.lastname: Strauss
authors.forename: Mekibib
authors.initials: M
authors.lastname: Altaye
authors.forename: Antonia M
authors.initials: AM
authors.lastname: Calafat
authors.forename: Jane
authors.initials: J
authors.lastname: Khoury
mesh_terms: D000328:Adult; D001559:Benzhydryl Compounds; D003993:Dibutyl Phthalate / Q000633:toxicity / Q000652:urine; D004051:Diethylhexyl Phthalate / Q000633:toxicity / Q000652:urine; D004785:Environmental Pollutants / Q000493:pharmacokinetics / Q000633:toxicity* / Q000652:urine; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D020258:Neurotoxicity Syndromes / Q000175:diagnosis*; D010636:Phenols / Q000633:toxicity* / Q000652:urine; D010795:Phthalic Acids / Q000493:pharmacokinetics / Q000633:toxicity* / Q000652:urine; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000523:psychology* / Q000652:urine; D013997:Time Factors; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D003993:Dibutyl Phthalate; D004051:Diethylhexyl Phthalate; D004785:Environmental Pollutants; D010636:Phenols; D010795:Phthalic Acids; C032279:phthalic acid; C006780:bisphenol A; D000098826:Bisphenol A Compounds