title: Evidence-based medicine and stem cell therapy: how do we know such technologies are safe and efficacious?
abstract: Evidence-based medicine (EBM) refers to the conscientious, explicit, and judicious use of current best evidence from research for the care of an individual patient. Central to the adoption of EBM is both producing and identifying the best possible evidence for a particular intervention or therapy. This article identifies and reviews the approaches to producing and identifying the best possible evidence that is necessary for the full acceptance of stem cell therapies in the horse and reviews the approaches that will allow future clinical studies in stem cell therapies to provide the best evidence for determining efficacy.
authors.affiliation: Department of Musculoskeletal Biology, University of Liverpool, Leahurst Campus, Chester High Road, Neston, Cheshire, CH64 7TE, UK. p.d.clegg@liverpool.ac.uk
authors.forename: Peter D
authors.initials: PD
authors.lastname: Clegg
authors.forename: Gina L
authors.initials: GL
authors.lastname: Pinchbeck
mesh_terms: D000818:Animals; D019317:Evidence-Based Medicine / Q000592:standards*; D006734:Horse Diseases / Q000628:therapy; D006736:Horses / Q000293:injuries*; D007592:Joint Diseases / Q000628:therapy; D008022:Ligaments / Q000293:injuries*; D033581:Stem Cell Transplantation / Q000662:veterinary*; D013708:Tendon Injuries / Q000628:therapy / Q000662:veterinary*; D014730:Veterinary Medicine / Q000592:standards* / Q000639:trends