title: Multimodal neuroimaging in patients with disorders of consciousness showing "functional hemispherectomy".
abstract: Beside behavioral assessment of patients with disorders of consciousness, neuroimaging modalities may offer objective paraclinical markers important for diagnosis and prognosis. They provide information on the structural location and extent of brain lesions (e.g., morphometric MRI and diffusion tensor imaging (DTI-MRI) assessing structural connectivity) but also their functional impact (e.g., metabolic FDG-PET, hemodynamic fMRI, and EEG measurements obtained in "resting state" conditions). We here illustrate the role of multimodal imaging in severe brain injury, presenting a patient in unresponsive wakefulness syndrome (UWS; i.e., vegetative state, VS) and in a "fluctuating" minimally conscious state (MCS). In both cases, resting state FDG-PET, fMRI, and EEG showed a functionally preserved right hemisphere, while DTI showed underlying differences in structural connectivity highlighting the complementarities of these neuroimaging methods in the study of disorders of consciousness.
authors.affiliation: Coma Science Group, Cyclotron Research Center, University and University Hospital of Liège, Liège, Belgium.
authors.forename: M A
authors.initials: MA
authors.lastname: Bruno
authors.forename: D
authors.initials: D
authors.lastname: Fernández-Espejo
authors.forename: R
authors.initials: R
authors.lastname: Lehembre
authors.forename: L
authors.initials: L
authors.lastname: Tshibanda
authors.forename: A
authors.initials: A
authors.lastname: Vanhaudenhuyse
authors.forename: O
authors.initials: O
authors.lastname: Gosseries
authors.forename: E
authors.initials: E
authors.lastname: Lommers
authors.forename: M
authors.initials: M
authors.lastname: Napolitani
authors.forename: Q
authors.initials: Q
authors.lastname: Noirhomme
authors.forename: M
authors.initials: M
authors.lastname: Boly
authors.forename: M
authors.initials: M
authors.lastname: Papa
authors.forename: A
authors.initials: A
authors.lastname: Owen
authors.forename: P
authors.initials: P
authors.lastname: Maquet
authors.forename: S
authors.initials: S
authors.lastname: Laureys
authors.forename: A
authors.initials: A
authors.lastname: Soddu
mesh_terms: D000293:Adolescent; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D001930:Brain Injuries / Q000473:pathology / Q000503:physiopathology; D003243:Consciousness / Q000502:physiology*; D003244:Consciousness Disorders / Q000473:pathology / Q000503:physiopathology*; D003952:Diagnostic Imaging / Q000379:methods; D056324:Diffusion Tensor Imaging; D004569:Electroencephalography; D038421:Hemispherectomy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D059906:Neuroimaging / Q000379:methods*; D009483:Neuropsychological Tests; D018458:Persistent Vegetative State / Q000473:pathology / Q000503:physiopathology; D049268:Positron-Emission Tomography; D055815:Young Adult