title: The retrovirus XMRV is not directly involved in the pathogenesis of common types of lymphoid malignancy.
abstract: BACKGROUND
  A novel retrovirus, xenotropic murine leukemia virus-related virus (XMRV), has been detected in prostate cancer samples and in peripheral blood mononuclear cells (PBMC) from patients with chronic fatigue syndrome. In addition, the virus has been identified in PBMCs from healthy controls. These data suggest that XMRV is circulating in the human population. XMRV is closely related to murine leukemia viruses, which cause lymphoid malignancies in mice. The aim of this study was to determine whether XMRV is directly associated with common forms of human lymphoma or leukemia.
  
  
  METHODS
  DNA samples from 368 patients with lymphoid malignancies and 139 patients with benign lymphadenopathy or other malignant disease were screened for XMRV, using three specific and sensitive quantitative PCR assays.
  
  
  RESULTS
  XMRV was not detected in any sample using any of the three assays.
  
  
  CONCLUSIONS
  The data suggest that this virus is not directly involved in the pathogenesis of common types of lymphoid malignancy and that XMRV is not a prevalent blood borne infection, at least in the United Kingdom.
  
  
  CONCLUSIONS
  There is no evidence that XMRV is associated with lymphoid malignancies, and further studies should resolve inconsistencies in results of studies examining XMRV prevalence.
authors.affiliation: LRF Virus Centre, MRC and University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
authors.forename: Elspeth M
authors.initials: EM
authors.lastname: Waugh
authors.forename: Ruth F
authors.initials: RF
authors.lastname: Jarrett
authors.forename: Lesley
authors.initials: L
authors.lastname: Shield
authors.forename: Dorothy
authors.initials: D
authors.lastname: Montgomery
authors.forename: Robert T G
authors.initials: RT
authors.lastname: Dean
authors.forename: Andrea
authors.initials: A
authors.lastname: Mitchell
authors.forename: Mel F
authors.initials: MF
authors.lastname: Greaves
authors.forename: Alice
authors.initials: A
authors.lastname: Gallagher
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000209:etiology* / Q000473:pathology; D007963:Leukocytes, Mononuclear / Q000821:virology*; D008223:Lymphoma / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D060888:Real-Time Polymerase Chain Reaction; D012192:Retroviridae Infections / Q000150:complications* / Q000235:genetics* / Q000821:virology; D058008:Xenotropic murine leukemia virus-related virus / Q000235:genetics*; D055815:Young Adult
chemical_list: D004279:DNA, Viral