title: Ductus arteriosus aneurysm with massive thrombosis of pulmonary artery and fetal hydrops.
abstract: Ductus arteriosus aneurysm (DAA) is a rare cardiovascular lesion usually diagnosed within the first 2 months of life, or less frequently in the 3rd trimester, by antenatal sonography. The true in utero incidence of DAA is unknown, as most affected fetuses are asymptomatic at birth. Potential complications include thromboembolism, rupture, and death. We report a unique lethal case of a large DAA detected by mid-2nd trimester fetal echocardiography, complicated by stricture and massive occlusive thrombosis extending into the pulmonary artery branches. Stricture and thrombosis of the DAA led to interruption of fetal circulation, cardiac failure, and fetal hydrops, ultimately resulting in fetal demise.
authors.affiliation: Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA.
authors.forename: Rachel M
authors.initials: RM
authors.lastname: Sheridan
authors.forename: Erik C
authors.initials: EC
authors.lastname: Michelfelder
authors.forename: Kyuran A
authors.initials: KA
authors.lastname: Choe
authors.forename: Allison
authors.initials: A
authors.lastname: Divanovic
authors.forename: Cong
authors.initials: C
authors.lastname: Liu
authors.forename: Stephanie
authors.initials: S
authors.lastname: Ware
authors.forename: Jerzy
authors.initials: J
authors.lastname: Stanek
mesh_terms: D000783:Aneurysm / Q000150:complications / Q000175:diagnosis*; D003251:Constriction, Pathologic / Q000150:complications / Q000151:congenital / Q000175:diagnosis; D004373:Ductus Arteriosus / Q000196:embryology / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D005313:Fetal Death; D006801:Humans; D015160:Hydrops Fetalis / Q000209:etiology / Q000473:pathology*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011296:Prenatal Diagnosis; D011651:Pulmonary Artery / Q000002:abnormalities* / Q000196:embryology; D020246:Venous Thrombosis / Q000150:complications / Q000151:congenital / Q000175:diagnosis*; D055815:Young Adult