title: Distribution of polymorphisms in cytochrome P450 2B6, histocompatibility complex P5, chemokine coreceptor 5, and interleukin 28B genes in inhabitants from the central area of Argentina.
abstract: OBJECTIVE
  The selection of the most appropriate treatment for several diseases relies on a number of factors such as environment, age, gender, and nutrition. Additionally, the contribution of different genetic polymorphisms to treatment efficacy has been largely recognized. The lack of information on the pharmacogenetic profile of our population prompted us to analyze the frequency of polymorphisms known to be relevant to achieve treatment efficacy with different therapeutic agents in viral infectious diseases, such as Hepatitis C and AIDS.
  
  
  RESULTS
  The allelic frequencies for the wild-type variant of the genes analyzed were cytochrome P450 2B6 (CYP2B6; rs3745274; 516G) 0.618 (95% confidence interval [CI]: 0.523, 0.711), chemokine coreceptor 5 (CCR5; rs333) 0.961 (95% CI: 0.942, 0.98), histocompatibility complex P5 (HCP5; rs2395029; 335T) 0.971 (95% CI: 0.937, 1), and interleukin 28B (IL28B; rs12979860; 12007005C) 0.656 (95% CI: 0.564, 0.747), respectively.
  
  
  CONCLUSIONS
  Our data indicate that the genetic profile of the population studied is similar to that reported for other Caucasian populations, with only slight differences for CYP2B6. Noteworthy, the considerable number of patients carrying CYP2B6 (516T) and IL28B (12007005T) alleles underlies the importance of considering pharmacogenetic testing before starting drug therapy protocols to prevent toxicity and/or lack of effectiveness in AIDS or hepatitis C virus infections.
authors.affiliation: Laboratorio de Análisis Clínicos Especializados, Córdoba, Argentina.
authors.forename: Cristian A
authors.initials: CA
authors.lastname: Galván
authors.forename: Osvaldo C
authors.initials: OC
authors.lastname: Elbarcha
authors.forename: Eduardo J
authors.initials: EJ
authors.lastname: Fernández
authors.forename: Dante M
authors.initials: DM
authors.lastname: Beltramo
authors.forename: Néstor W
authors.initials: NW
authors.lastname: Soria
mesh_terms: D000293:Adolescent; D000328:Adult; D001118:Argentina; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D065702:Cytochrome P-450 CYP2B6; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy / Q000235:genetics; D006526:Hepatitis C / Q000188:drug therapy / Q000235:genetics; D006801:Humans; D007372:Interferons; D007378:Interleukins / Q000235:genetics*; D008285:Major Histocompatibility Complex / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010089:Oxidoreductases, N-Demethylating / Q000235:genetics*; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D019713:Receptors, CCR5 / Q000235:genetics*; D044465:White People / Q000235:genetics*; D055815:Young Adult; D000095022:Interferon Lambda
chemical_list: D001189:Aryl Hydrocarbon Hydroxylases; D065702:Cytochrome P-450 CYP2B6; D007372:Interferons; D007378:Interleukins; D010089:Oxidoreductases, N-Demethylating; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D019713:Receptors, CCR5; C080521:HCP5 long noncoding RNA, human; C000624353:interferon-lambda, human; D000095022:Interferon Lambda; C585599:CYP2B6 protein, human