title: Highly stereoselective synthesis of 1,2,3-trisubstituted indanes via oxidative N-heterocyclic carbene-catalyzed cascades.
abstract: Three stereocenters are formed in the carbene catalyzed cascade reaction of enals with various β-diketones to give the corresponding indane derivatives with excellent stereoselectivities. The products are readily transformed to the corresponding 1,2,3-trisubstituted indane derivatives, which represent privileged substructures in medicinal chemistry.
authors.affiliation: Organisch-Chemisches Institut, NRW Graduate School of Chemistry, University of Münster, Corrensstrasse 40, 48149 Münster, Germany.
authors.forename: Anup
authors.initials: A
authors.lastname: Biswas
authors.forename: Suman
authors.initials: S
authors.lastname: De Sarkar
authors.forename: Roland
authors.initials: R
authors.lastname: Fröhlich
authors.forename: Armido
authors.initials: A
authors.lastname: Studer
mesh_terms: D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry*; D007189:Indans / Q000138:chemical synthesis* / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D006571:Heterocyclic Compounds; D007189:Indans; C030011:carbene; D008697:Methane