title: Paracaseolide A, first α-alkylbutenolide dimer with an unusual tetraquinane oxa-cage bislactone skeleton from Chinese mangrove Sonneratia paracaseolaris.
abstract: A novel α-alkylbutenolide dimer, paracaseolide A (2), characterized by an unusual tetraquinane oxa-cage bislactone skeleton bearing two linear alkyl chains, was isolated from the mangrove plant Sonneratia paracaseolaris. The structure of 2 was elucidated by extensive spectroscopic analysis. A plausible retrosynthetic pathway for paracaseolide A (2) was proposed. Compound 2 exhibited significant inhibitory activity against dual specificity phosphatase CDC25B, a key enzyme for cell cycle progression, with an IC(50) value of 6.44 μM.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zu Chong Zhi Road, 555, Shanghai 201203, China.
authors.forename: Xue-Lian
authors.initials: XL
authors.lastname: Chen
authors.forename: Hai-Li
authors.initials: HL
authors.lastname: Liu
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.forename: Guo-Rong
authors.initials: GR
authors.lastname: Xin
authors.forename: Yue-Wei
authors.initials: YW
authors.lastname: Guo
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D019281:Dimerization; D029561:Lythraceae / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: C569208:paracaseolide A; C004511:butenolide; D015107:4-Butyrolactone