title: Triorganotin as a compound with potential reproductive toxicity in mammals.
abstract: Organotin compounds are typical environmental contaminants and suspected endocrine-disrupting substances, which cause irreversible sexual abnormality in female mollusks, called "imposex". However, little is known about the capability of triorganotin compounds, such as tributyltin and triphenyltin, to cause disorders in the sexual development and reproductive functions of mammals, including humans and rodents. Moreover, these compounds can act as potential competitive inhibitors of aromatase enzyme and other steroidogenic enzymes, affecting the reproductive capacity of male and female mammals. In this review, we discuss the cellular, biochemical, and molecular mechanisms by which triorganotin compounds induce adverse effects in the mammalian reproductive function.
authors.affiliation: Laboratório de Biologia Celular do Envelhecimento, Departamento de Morfologia, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, Vitória, ES, Brasil.
authors.forename: V S
authors.initials: VS
authors.lastname: Delgado Filho
authors.forename: P F I
authors.initials: PF
authors.lastname: Lopes
authors.forename: P L
authors.initials: PL
authors.lastname: Podratz
authors.forename: J B
authors.initials: JB
authors.lastname: Graceli
mesh_terms: D000818:Animals; D001141:Aromatase / Q000187:drug effects; D004703:Endocrine System / Q000187:drug effects; D005260:Female; D005835:Genitalia / Q000187:drug effects*; D006801:Humans; D008297:Male; D008322:Mammals / Q000502:physiology*; D009947:Organotin Compounds / Q000633:toxicity*; D012098:Reproduction / Q000187:drug effects; D014220:Trialkyltin Compounds / Q000633:toxicity*
chemical_list: D009947:Organotin Compounds; D014220:Trialkyltin Compounds; C011559:tributyltin; C030665:triphenyltin; D001141:Aromatase