title: Discovery of a new class of HMG-CoA reductase inhibitor from Polyalthia longifolia as potential lipid lowering agent.
abstract: Bioassay guided fractionation of the ethanolic extract of Polyalthia longifolia var. pendula, led to the discovery of the clerodane diterpene, 16α-hydroxycleroda-3, 13 (14) Z-dien-15, 16-olide (1), as a new structural class of HMG-CoA reductase inhibitor. Importantly, the in vivo effects of 1 corroborated well with its molecular docking analysis and also with its hamster plasma pharmacokinetics.
authors.affiliation: Medicinal and Process Chemistry Division, Central Drug Research Institute (CSIR), Chattar Manzil Palace, M.G. Marg, Lucknow 226001, India. sashidhar123@gmail.com
authors.forename: Koneni V
authors.initials: KV
authors.lastname: Sashidhara
authors.forename: Suriya P
authors.initials: SP
authors.lastname: Singh
authors.forename: Anuj
authors.initials: A
authors.lastname: Srivastava
authors.forename: Anju
authors.initials: A
authors.lastname: Puri
authors.forename: Yashpal S
authors.initials: YS
authors.lastname: Chhonker
authors.forename: Rabi S
authors.initials: RS
authors.lastname: Bhatta
authors.forename: Priyanka
authors.initials: P
authors.lastname: Shah
authors.forename: Mohammad Imran
authors.initials: MI
authors.lastname: Siddiqi
mesh_terms: D000818:Animals; D006224:Cricetinae; D045785:Diterpenes, Clerodane / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases / Q000737:chemistry / Q000378:metabolism; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D050356:Lipid Metabolism / Q000187:drug effects; D008055:Lipids / Q000097:blood; D008297:Male; D008958:Models, Molecular; D010936:Plant Extracts / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D031044:Polyalthia / Q000737:chemistry*
chemical_list: D045785:Diterpenes, Clerodane; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000960:Hypolipidemic Agents; D008055:Lipids; D010936:Plant Extracts; D006903:Hydroxymethylglutaryl CoA Reductases