title: Garlic and onion attenuates vascular inflammation and oxidative stress in fructose-fed rats.
abstract: This study evaluates the antioxidant and the anti-inflammatory properties of garlic (G) and onion (O) in fructose-fed rats (FFR). Thirty-day-old male Wistar rats were assigned to control (C), F (10% fructose in drinking water), F+T (tempol 1 mM as control antioxidant), F+G, and F+O. Aqueous G and O extracts were administered orally in doses of 150 and 400 mg/kg/d respectively, and along with tempol, were given during the last 8 weeks of a 14-week period. At the end of the study, FFR had developed insulin resistance, aortic NADPH oxidase activity, increased SBP, plasma TBARS and vascular cell adhesion molecule-1 (VCAM-1) expression in mesenteric arteries, and a decrease in heart endothelial nitric oxide synthase (eNOS). Garlic and onion administration to F rats reduced oxidative stress, increased eNOS activity, and also attenuated VCAM-1 expression. These results provide new evidence showing the anti-inflammatory and antioxidant effect of these vegetables.
authors.affiliation: Departamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Avenida Libertador 80, 5500 Mendoza, Argentina.
authors.forename: Marcela Alejandra
authors.initials: MA
authors.lastname: Vazquez-Prieto
authors.forename: Cecilia
authors.initials: C
authors.lastname: Rodriguez Lanzi
authors.forename: Carina
authors.initials: C
authors.lastname: Lembo
authors.forename: Claudio Rómulo
authors.initials: CR
authors.lastname: Galmarini
authors.forename: Roberto Miguel
authors.initials: RM
authors.lastname: Miatello