title: The beta2-adrenergic receptor on T and B lymphocytes: do we understand it yet?
abstract: The role played by the beta2-adrenergic receptor (β(2)AR) in regulating the level of T and B lymphocyte function has been studied for over half a century. During this time, we have learned that T and B lymphocytes express almost exclusively the β(2)AR, and that the level of expression on a specific lymphocyte subset differs due to epigenetic regulation by histone and DNA methylation. We have also learned that engagement of the β(2)AR on lymphocytes, by either norepinephrine or a selective pharmacologic ligand, regulates the level of lymphocyte activity differentially, depending on the time of receptor engagement in relation to the activation and differentiation state of the cell, the molecular signaling pathway activated, and the cytokine microenvironment. The challenge now is to determine if we understand enough about how this receptor functions on lymphocytes to predict the relevance of such regulation to overall immune homeostasis and the development/progression of human disease.
authors.affiliation: Department of Molecular Virology, Immunology and Medical Genetics, The Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, Columbus, OH 43210, United States. Virginia.Sanders@osumc.edu
authors.forename: Virginia M
authors.initials: VM
authors.lastname: Sanders
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000502:physiology*; D051940:B7-2 Antigen / Q000502:physiology; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology; D006801:Humans; D007074:Immunoglobulin G / Q000502:physiology; D008213:Lymphocyte Activation / Q000187:drug effects / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology; D018343:Receptors, Adrenergic, beta-2 / Q000187:drug effects / Q000502:physiology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000502:physiology*; D018417:Th1 Cells / Q000502:physiology; D018418:Th2 Cells / Q000502:physiology
chemical_list: D051940:B7-2 Antigen; D007074:Immunoglobulin G; D018343:Receptors, Adrenergic, beta-2; D009638:Norepinephrine