title: Meeting the (N-terminal) end with acetylation.
abstract: Cell-fate decisions are tightly linked to cellular energy status. In this issue, Yi et al. (2011) introduce a mechanism by which Bcl-xL lowers the threshold for apoptosis by suppressing acetyl-CoA production, which, in turn, suppresses the N-alpha-acetylation important for activation of the proapoptotic protease caspase-2.
authors.affiliation: Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Joshua L
authors.initials: JL
authors.lastname: Andersen
authors.forename: Sally
authors.initials: S
authors.lastname: Kornbluth