title: Automated identification of postoperative complications within an electronic medical record using natural language processing.
abstract: BACKGROUND
  Currently most automated methods to identify patient safety occurrences rely on administrative data codes; however, free-text searches of electronic medical records could represent an additional surveillance approach.
  
  
  OBJECTIVE
  To evaluate a natural language processing search-approach to identify postoperative surgical complications within a comprehensive electronic medical record.
  
  
  METHODS
  Cross-sectional study involving 2974 patients undergoing inpatient surgical procedures at 6 Veterans Health Administration (VHA) medical centers from 1999 to 2006.
  
  
  METHODS
  Postoperative occurrences of acute renal failure requiring dialysis, deep vein thrombosis, pulmonary embolism, sepsis, pneumonia, or myocardial infarction identified through medical record review as part of the VA Surgical Quality Improvement Program. We determined the sensitivity and specificity of the natural language processing approach to identify these complications and compared its performance with patient safety indicators that use discharge coding information.
  
  
  RESULTS
  The proportion of postoperative events for each sample was 2% (39 of 1924) for acute renal failure requiring dialysis, 0.7% (18 of 2327) for pulmonary embolism, 1% (29 of 2327) for deep vein thrombosis, 7% (61 of 866) for sepsis, 16% (222 of 1405) for pneumonia, and 2% (35 of 1822) for myocardial infarction. Natural language processing correctly identified 82% (95% confidence interval [CI], 67%-91%) of acute renal failure cases compared with 38% (95% CI, 25%-54%) for patient safety indicators. Similar results were obtained for venous thromboembolism (59%, 95% CI, 44%-72% vs 46%, 95% CI, 32%-60%), pneumonia (64%, 95% CI, 58%-70% vs 5%, 95% CI, 3%-9%), sepsis (89%, 95% CI, 78%-94% vs 34%, 95% CI, 24%-47%), and postoperative myocardial infarction (91%, 95% CI, 78%-97%) vs 89%, 95% CI, 74%-96%). Both natural language processing and patient safety indicators were highly specific for these diagnoses.
  
  
  CONCLUSIONS
  Among patients undergoing inpatient surgical procedures at VA medical centers, natural language processing analysis of electronic medical records to identify postoperative complications had higher sensitivity and lower specificity compared with patient safety indicators based on discharge coding.
authors.affiliation: Tennessee Valley Healthcare System, Veterans Affairs Medical Center, Nashville, TN, USA. harvey.j.murff@vanderbilt.edu
authors.forename: Harvey J
authors.initials: HJ
authors.lastname: Murff
authors.forename: Fern
authors.initials: F
authors.lastname: FitzHenry
authors.forename: Michael E
authors.initials: ME
authors.lastname: Matheny
authors.forename: Nancy
authors.initials: N
authors.lastname: Gentry
authors.forename: Kristen L
authors.initials: KL
authors.lastname: Kotter
authors.forename: Kimberly
authors.initials: K
authors.lastname: Crimin
authors.forename: Robert S
authors.initials: RS
authors.lastname: Dittus
authors.forename: Amy K
authors.initials: AK
authors.lastname: Rosen
authors.forename: Peter L
authors.initials: PL
authors.lastname: Elkin
authors.forename: Steven H
authors.initials: SH
authors.lastname: Brown
authors.forename: Theodore
authors.initials: T
authors.lastname: Speroff
mesh_terms: D001331:Automation; D003430:Cross-Sectional Studies; D003953:Diagnosis-Related Groups; D057286:Electronic Health Records; D006760:Hospitalization; D006787:Hospitals, Veterans / Q000706:statistics & numerical data; D006801:Humans; D016247:Information Storage and Retrieval; D007297:Inpatients; D038801:International Classification of Diseases; D009203:Myocardial Infarction / Q000453:epidemiology; D009323:Natural Language Processing; D010351:Patient Discharge / Q000706:statistics & numerical data; D011014:Pneumonia / Q000453:epidemiology; D011159:Population Surveillance; D011183:Postoperative Complications / Q000453:epidemiology*; D011655:Pulmonary Embolism / Q000453:epidemiology; D019984:Quality Indicators, Health Care; D051437:Renal Insufficiency / Q000453:epidemiology; D012449:Safety; D012680:Sensitivity and Specificity; D018805:Sepsis / Q000453:epidemiology; D013514:Surgical Procedures, Operative; D014481:United States / Q000453:epidemiology; D020246:Venous Thrombosis / Q000453:epidemiology