title: Erlotinib accumulation in brain metastases from non-small cell lung cancer: visualization by positron emission tomography in a patient harboring a mutation in the epidermal growth factor receptor.
abstract: BACKGROUND
  Drugs directed toward the epidermal growth factor receptor (EGFR), such as erlotinib (Tarceva®) and gefitinib (Iressa®), are used for the treatment of patients with advanced non-small cell lung cancer (NSCLC), including patients with brain metastases. However, whether erlotinib actually enters into brain metastases has not been adequately elucidated. In this study, we investigated the accumulation of [¹¹C]-erlotinib by positron emission tomography (PET) combined with computed tomography (CT) and magnetic resonance imaging (MRI).
  
  
  METHODS
  A 32-year-old patient with NSCLC and multiple brain metastases was treated with first-line erlotinib. EGFR mutations were determined by analyzing a fine-needle lung tumor biopsy taken before the treatment. A PET/CT of the brain with [¹¹C]-erlotinib was performed during treatment, and a MRI of the head and a CT of the chest were performed pre- and posttreatment.
  
  
  RESULTS
  The primary lung tumor displayed an erlotinib-sensitizing exon 19 deletion in the EGFR gene, and [¹¹C]-erlotinib PET/CT showed accumulation in the brain metastases. Posttreatment MRI and CT demonstrated regression of both brain metastases and primary lung tumor.
  
  
  CONCLUSIONS
  Our data demonstrated that erlotinib accumulated in brain metastases in a NSCLC patient who responded to the treatment.
authors.affiliation: Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark. britwebe@rm.dk
authors.forename: Britta
authors.initials: B
authors.lastname: Weber
authors.forename: Michael
authors.initials: M
authors.lastname: Winterdahl
authors.forename: Ashfaque
authors.initials: A
authors.lastname: Memon
authors.forename: Boe S
authors.initials: BS
authors.lastname: Sorensen
authors.forename: Susanne
authors.initials: S
authors.lastname: Keiding
authors.forename: Leif
authors.initials: L
authors.lastname: Sorensen
authors.forename: Ebba
authors.initials: E
authors.lastname: Nexo
authors.forename: Peter
authors.initials: P
authors.lastname: Meldgaard
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000235:genetics* / Q000556:secondary; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D066246:ErbB Receptors / Q000235:genetics*; D000069347:Erlotinib Hydrochloride; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D009154:Mutation / Q000235:genetics*; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D011379:Prognosis; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D011799:Quinazolines / Q000494:pharmacology*; D015996:Survival Rate; D014057:Tomography, X-Ray Computed
chemical_list: D047428:Protein Kinase Inhibitors; D011799:Quinazolines; D000069347:Erlotinib Hydrochloride; C512478:EGFR protein, human; D066246:ErbB Receptors