title: Dietary factors and lung function in the general population: wine and resveratrol intake.
abstract: Wine intake is associated with a better lung function in the general population, yet the source of this effect is unknown. Resveratrol, a polyphenol in wine, has anti-inflammatory properties in the lung, its effects being partially mediated via induction of Sirtuin (SIRT)1 activity. We assessed the impact of wine and resveratrol intake, and SIRT1 single-nucleotide polymorphisms (SNPs) on lung function in the general population. Effects of red and white wine and resveratrol intake on forced expiratory volume in 1 s (FEV(1)), forced vital capacity (FVC) and FEV(1)/FVC were analysed in the population-based Doetinchem cohort (n=3,224). Associations of four tagging SIRT1 SNPs with lung function were analysed in the Doetinchem (n=1,152) and Vlagtwedde-Vlaardingen (n=1,390) cohorts. Resveratrol intake was associated with higher FVC levels, and white wine intake with higher FEV(1) levels and lower risk of airway obstruction. SIRT1 SNPs were not significantly associated with level or course of lung function, either directly or indirectly via wine or resveratrol intake. This study shows a positive association of resveratrol intake with lung function in the general population, confirms the previously reported positive association of white wine intake with higher levels of FEV(1), and additionally shows an association with a higher FEV(1)/FVC ratio. These effects probably do not run via SNPs in SIRT1.
authors.affiliation: Dept of Epidemiology, E3.29, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Siedlinski
authors.forename: J M A
authors.initials: JM
authors.lastname: Boer
authors.forename: H A
authors.initials: HA
authors.lastname: Smit
authors.forename: D S
authors.initials: DS
authors.lastname: Postma
authors.forename: H M
authors.initials: HM
authors.lastname: Boezen
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000627:therapeutic use*; D015331:Cohort Studies; D005247:Feeding Behavior; D005260:Female; D005541:Forced Expiratory Volume; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D008168:Lung / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D029424:Pulmonary Disease, Chronic Obstructive / Q000178:diet therapy / Q000453:epidemiology* / Q000235:genetics; D000077185:Resveratrol; D012307:Risk Factors; D056564:Sirtuin 1 / Q000235:genetics*; D013267:Stilbenes / Q000627:therapeutic use*; D014797:Vital Capacity; D014920:Wine
chemical_list: D000975:Antioxidants; D013267:Stilbenes; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D000077185:Resveratrol