title: Green tea: a new option for the prevention or control of osteoarthritis.
abstract: IL-1β is a major cytokine driving the inflammatory processes leading to the pathophysiology of osteoarthritis and other inflammatory diseases. Blockade of IL-1β activity using substances such as the naturally occurring IL-1 receptor antagonist or anti-IL-1β monoclonal antibody are currently being used or tested as therapy. However, such treatments are ineffective in osteoarthritis. In a recent study, epigallocatechin-3-gallate, a green tea polyphenol, was found to be effective in reducing IL-1β-induced inflammatory cytokines, TNFα, IL-6, granulocyte-macrophage colony-stimulating factor and several chemokines from human chondrocytes. The use of green tea polyphenols may be beneficial as a therapeutic addition to biologics that control IL-1β activity by increasing effectiveness and/or reducing dosage.
authors.forename: Santosh K
authors.initials: SK
authors.lastname: Katiyar
authors.forename: Chander
authors.initials: C
authors.lastname: Raman
mesh_terms: D002392:Catechin / Q000031:analogs & derivatives*; D019902:Chondrocytes / Q000187:drug effects*; D006801:Humans; D053583:Interleukin-1beta / Q000494:pharmacology*; D010003:Osteoarthritis / Q000188:drug therapy* / Q000473:pathology*
chemical_list: D053583:Interleukin-1beta; D002392:Catechin