title: Using boronolectin in MALDI-MS imaging for the histological analysis of cancer tissue expressing the sialyl Lewis X antigen.
abstract: Certain carbohydrate-based biomarkers are known to correlate with cancer formation and progression. By targeting sialyl Lewis X, we have developed the first boronolectin-MS tag conjugate, which allows for MALDI-based imaging of cancer based on its cell surface carbohydrate.
authors.affiliation: Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia 30302-4098, USA.
authors.forename: Chaofeng
authors.initials: C
authors.lastname: Dai
authors.forename: Lisa H
authors.initials: LH
authors.lastname: Cazares
authors.forename: Lifang
authors.initials: L
authors.lastname: Wang
authors.forename: Yong
authors.initials: Y
authors.lastname: Chu
authors.forename: Siming L
authors.initials: SL
authors.lastname: Wang
authors.forename: Dean A
authors.initials: DA
authors.lastname: Troyer
authors.forename: O John
authors.initials: OJ
authors.lastname: Semmes
authors.forename: Richard R
authors.initials: RR
authors.lastname: Drake
authors.forename: Binghe
authors.initials: B
authors.lastname: Wang
mesh_terms: D001896:Boron Compounds / Q000138:chemical synthesis / Q000378:metabolism*; D002292:Carcinoma, Renal Cell / Q000378:metabolism / Q000473:pathology*; D015972:Gene Expression Regulation, Neoplastic; D007680:Kidney Neoplasms / Q000378:metabolism / Q000473:pathology*; D016256:Lewis X Antigen / Q000378:metabolism*; D057054:Molecular Imaging / Q000379:methods*; D009005:Monosaccharides / Q000138:chemical synthesis / Q000378:metabolism*; D000080506:Sialyl Lewis X Antigen; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*
chemical_list: D001896:Boron Compounds; D016256:Lewis X Antigen; D009005:Monosaccharides; D000080506:Sialyl Lewis X Antigen; C541244:boronolectin