title: Laparoscopic-assisted versus open resection of right-sided colonic cancer--a prospective randomized controlled trial.
abstract: OBJECTIVE
  This study aims to compare the perioperative outcomes and survival between laparoscopic-assisted right hemicolectomy (LARH) and open right hemicolectomy (ORH) for right-sided colon cancer.
  
  
  METHODS
  Between July 1996 and October 2005, 145 patients were randomized to receive LARH (n = 71) or ORH (n = 74).
  
  
  RESULTS
  The median follow-up of living patients was 99.7 months. The demographic data of the two groups were similar. The time to resume diet (4 vs. 5 days, p = 0.045) and the hospital stay (7.8 vs. 10 days, p = 0.033) were significantly shorter in LARH group, but these benefits were at the expense of longer operating time (198 vs. 129 min, p = 0.002) and higher direct cost (USD8745 vs. USD6293, p < 0.001). The morbidity and mortality were comparable between the two groups. After curative resection, the probabilities of survival at 5 years of the LARH and ORH groups were 74.2% (SE 7.4%) and 75% (SE 7.1%), respectively. The probabilities of being disease free at 5 years were 82.3% (SE 6.9%) and 84.1% (SE 6.2%), respectively.
  
  
  CONCLUSIONS
  Laparoscopic-assisted resection of right-sided colonic cancer has the advantage over open surgery in allowing earlier recovery. However this is at the expense of a longer operating time and higher direct cost (registration number: NCT00485316 ( http://www.clinicaltrials.gov )).
authors.affiliation: Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China. jimmylicm@hotmail.com
authors.forename: Jimmy Chak-Man
authors.initials: JC
authors.lastname: Li
authors.forename: Ka Lau
authors.initials: KL
authors.lastname: Leung
authors.forename: Simon Siu-Man
authors.initials: SS
authors.lastname: Ng
authors.forename: Shirley Yuk-Wa
authors.initials: SY
authors.lastname: Liu
authors.forename: Janet Fung-Yee
authors.initials: JF
authors.lastname: Lee
authors.forename: Sophie Sok-Fei
authors.initials: SS
authors.lastname: Hon
mesh_terms: D000368:Aged; D003110:Colonic Neoplasms / Q000601:surgery*; D003710:Demography; D018572:Disease-Free Survival; D023381:Endpoint Determination; D005260:Female; D006801:Humans; D010535:Laparoscopy; D008297:Male; D019990:Perioperative Care; D011183:Postoperative Complications / Q000209:etiology; D011446:Prospective Studies; D012008:Recurrence; D016896:Treatment Outcome