title: miR than meets the eye.
abstract: Retinoblastoma is a rare pediatric cancer that has served as a paradigm to investigate the mechanisms of tumorigenesis. In this issue of Genes & Development, Conkrite and colleagues (pp. 1734-1745) found high levels of the miR-17~92 and miR-106b-25 microRNAs in primary retinoblastomas and show that overexpression of miR-17~92 accelerates retinoblastoma development in mice by promoting proliferation, in part by reducing expression of the cell cycle inhibitor p21. These experiments identify the RB/miR-17~92/p21 axis as a critical regulator of retinoblastoma tumorigenesis and potentially many other cancers.
authors.affiliation: Department of Pediatrics, Stanford University, Stanford, California 94305, USA.
authors.forename: Julien
authors.initials: J
authors.lastname: Sage
authors.forename: Andrea
authors.initials: A
authors.lastname: Ventura
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D009154:Mutation; D011247:Pregnancy; D012175:Retinoblastoma / Q000235:genetics*; D016160:Retinoblastoma Protein / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics*
chemical_list: D035683:MicroRNAs; D016160:Retinoblastoma Protein