title: Short term effects of copper, sulfadiazine and difloxacin on the anaerobic digestion of pig manure at low organic loading rates.
abstract: Antibiotics of inorganic and organic origin in pig manure can inhibit the anaerobic process in biogas plants. The influence of three frequently used antibiotics, copper dosed as CuSO(4), sulfadiazine (SDZ), and difloxacin (DIF), on the anaerobic digestion process of pig manure was studied in semi-continuous experiments. Biogas production recovered after every Cu dosage up to a sum of 12.94g Cukg(-1) organic dry matter (ODM), probably due to Cu precipitation following the formation of sulphide from sulphate. Complete inhibition was found at the very high Cu concentration of 19.40g Cukg(-1) ODM. Inhibitory effect of SDZ and DIF was observed at concentrations as high as 2.70gkg(-1) ODM and 0.54gkg(-1) ODM, respectively. It seems very unlikely that the antibiotics tested would inhibit the anaerobic process in a full-scale biogas plant.
authors.affiliation: College of Water Conservancy and Civil Engineering, China Agricultural University, P.O. Box 184, Beijing 100083, PR China. jianbinguo@gmail.com
authors.forename: Jianbin
authors.initials: J
authors.lastname: Guo
authors.forename: Anne
authors.initials: A
authors.lastname: Ostermann
authors.forename: Jan
authors.initials: J
authors.lastname: Siemens
authors.forename: Renjie
authors.initials: R
authors.lastname: Dong
authors.forename: Joachim
authors.initials: J
authors.lastname: Clemens
mesh_terms: D000693:Anaerobiosis; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D056804:Biofuels / Q000032:analysis*; D001711:Biotransformation / Q000187:drug effects*; D002939:Ciprofloxacin / Q000031:analogs & derivatives / Q000494:pharmacology; D019327:Copper Sulfate / Q000494:pharmacology*; D008372:Manure; D000432:Methanol / Q000494:pharmacology; D013411:Sulfadiazine / Q000494:pharmacology; D013552:Swine
chemical_list: D000900:Anti-Bacterial Agents; D056804:Biofuels; D008372:Manure; D013411:Sulfadiazine; D002939:Ciprofloxacin; C047225:difloxacin; D019327:Copper Sulfate; D000432:Methanol