title: Combinatorial synthesis of galactosyl-1,3,5-triazines as novel nucleoside analogues.
abstract: Herein we report a parallel solid-phase synthesis of 1,3,5-triazine based nucleoside analogues by a three-step substitution, starting from 2,4,6-trichloro-1,3,5-triazine. A library of 80 galactosyl-1,3,5-triazine compounds was prepared in high purity without extensive reaction conditions or tedious purification, suggesting the generality of this method.
authors.affiliation: Department of Chemistry, Stanford University, California 94305, USA.
authors.forename: Shenliang
authors.initials: S
authors.lastname: Wang
authors.forename: Woo Sirl
authors.initials: WS
authors.lastname: Lee
authors.forename: Hyung-Ho
authors.initials: HH
authors.lastname: Ha
authors.forename: Young-Tae
authors.initials: YT
authors.lastname: Chang
mesh_terms: D005690:Galactose / Q000737:chemistry*; D015394:Molecular Structure; D009705:Nucleosides / Q000737:chemistry*; D014227:Triazines / Q000138:chemical synthesis*
chemical_list: D009705:Nucleosides; D014227:Triazines; D005690:Galactose