title: [Vimentin and glial fibrillary acidic protein in the cells of ectopic neurotarnsplants of rat neocortex].
abstract: The purpose of this study was to investigate the expression of intermediate filament proteins (vimentin and glial fibrillary acidic protein--GFAP) in the cells of embryonic rat neocortex at different time points after its allotransplantation into injured sciatic nerve of adult animals. Using immunohistochemical methods, the differentiation of GFAP-positive astrocytes from vimentin-positive radial glial cells was observed in embryonic rat neocortex, grafted into sciatic nerve. It was shown that the differentiation of the embryonic neocortical astrocytes in the transplants took place a few days earlier than in the rat neocortex during normal ontogenesis. Reactive gliosis was demonstrated in the long-term transplants, as indicated by a large number of intensely stained GFAP-positive cells and vimentin-containing astrocytes. These findings suggest that ectopic neurotarnsplants could serve as a model for fundamental studies of the mechanisms of reactive gliosis development.
authors.forename: E S
authors.initials: ES
authors.lastname: Petrova
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology; D002828:Choristoma / Q000378:metabolism*; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism*; D005911:Gliosis / Q000378:metabolism*; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D019579:Neocortex / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000166:cytology / Q000293:injuries / Q000378:metabolism; D013997:Time Factors; D014184:Transplantation, Homologous / Q000502:physiology; D014746:Vimentin / Q000378:metabolism*
chemical_list: D005904:Glial Fibrillary Acidic Protein; D014746:Vimentin