title: Amelioration of chemical-induced skin carcinogenesis by Aegle marmelos, an Indian medicinal plant, fruit extract.
abstract: Chemoprevention is a novel approach to study the anti-initiating and anti-tumor-promoting efficacy of medicinal plants and their active principles. The present study investigated the chemopreventive potential of Aegle marmelos fruit extract in 7,12-dimethylbenz[a]anthracene-induced skin carcinogenesis and its influence on oxidative stress and the antioxidant defense system. The oral administration of A marmelos at 100 mg/kg body weight/day during peri-initiational, postinitiational, and peri- & postinitiational phases of papillomagenesis showed significant reduction in tumor incidence, tumor yield, tumor burden, and cumulative number of papillomas when compared with carcinogen-treated control. The average latent period significantly increased (7.88 weeks; control group) to 9.45, 11.11, and 11.54 weeks in different A marmelos extract (AME) experimental groups. Enzyme analysis of skin and liver showed a significant elevation in antioxidant parameters such as superoxide dismutase, catalase, glutathione, and vitamin C in AME-treated groups when compared with the carcinogen-treated control. The elevated level of lipid peroxidation in the positive control was significantly inhibited by AME administration. These results indicate that AME has the potential to reduce chemical-induced skin papillomas by enhancing the antioxidant defense system.
authors.affiliation: University of Rajasthan, Jaipur, Rajasthan, India.
authors.forename: Annapurna
authors.initials: A
authors.lastname: Agrawal
authors.forename: Swafiya
authors.initials: S
authors.lastname: Jahan
authors.forename: Dhanraj
authors.initials: D
authors.lastname: Soyal
authors.forename: Ekank
authors.initials: E
authors.lastname: Goyal
authors.forename: Pradeep Kumar
authors.initials: PK
authors.lastname: Goyal
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity; D000284:Administration, Oral; D045471:Aegle / Q000737:chemistry*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D004195:Disease Models, Animal; D007194:India; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects; D010212:Papilloma / Q000139:chemically induced / Q000517:prevention & control*; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D047368:Tumor Burden / Q000187:drug effects
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D015127:9,10-Dimethyl-1,2-benzanthracene