title: Yb(OTf)3 catalyzed new cascade reaction: a facile assembly of fused quinazolinones.
abstract: A one-pot Yb(III)-mediated cascade reaction has been developed leading to small molecules based on a novel structural motif, i.e. quinazolin-4-one moiety fused with an isoquinoline ring, for potential inhibition of TNF-α.
authors.affiliation: Custom Pharmaceutical Services, Dr Reddy's Laboratories Limited, Bollaram Road Miyapur, Hyderabad 500 049, India.
authors.forename: K Siva
authors.initials: KS
authors.lastname: Kumar
authors.forename: P Mahesh
authors.initials: PM
authors.lastname: Kumar
authors.forename: M Appi
authors.initials: MA
authors.lastname: Reddy
authors.forename: Md
authors.initials: M
authors.lastname: Ferozuddin
authors.forename: M
authors.initials: M
authors.lastname: Sreenivasulu
authors.forename: Ahamed A
authors.initials: AA
authors.lastname: Jafar
authors.forename: G R
authors.initials: GR
authors.lastname: Krishna
authors.forename: C Malla
authors.initials: CM
authors.lastname: Reddy
authors.forename: D
authors.initials: D
authors.lastname: Rambabu
authors.forename: K Shiva
authors.initials: KS
authors.lastname: Kumar
authors.forename: Sarbani
authors.initials: S
authors.lastname: Pal
authors.forename: Manojit
authors.initials: M
authors.lastname: Pal
mesh_terms: D002384:Catalysis; D008698:Mesylates / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D008698:Mesylates; D009942:Organometallic Compounds; D052999:Quinazolinones; D014409:Tumor Necrosis Factor-alpha; C518808:ytterbium(III) triflate