title: Three-step synthesis of cyclopropyl peptidomimetics.
abstract: An efficient approach to novel cyclopropyl peptidomimetics has been developed. The synthetic route involves a cyclopropanation using ethyl (dimethylsulfuranylidene)acetate (EDSA) as the key step and affords a cyclopropyl peptidomimetic core in three steps from protected amino acid Weinreb amides.
authors.affiliation: Middle Tennessee State University, Department of Chemistry, Murfreesboro, Tennessee 37132, USA. ndunlap@mtsu.edu
authors.forename: Norma
authors.initials: N
authors.lastname: Dunlap
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Lankford
authors.forename: Anuradha Liyana
authors.initials: AL
authors.lastname: Pathiranage
authors.forename: Jessica
authors.initials: J
authors.lastname: Taylor
authors.forename: Nikhil
authors.initials: N
authors.lastname: Reddy
authors.forename: Daniel
authors.initials: D
authors.lastname: Gouger
authors.forename: Phillip
authors.initials: P
authors.lastname: Singer
authors.forename: Kent
authors.initials: K
authors.lastname: Griffin
authors.forename: Joseph
authors.initials: J
authors.lastname: Reibenspies
mesh_terms: D018360:Crystallography, X-Ray; D003500:Cyclization; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D057786:Peptidomimetics / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D003521:Cyclopropanes; D057786:Peptidomimetics; C030797:cyclopropane