title: Asystole after the first dose of ceftriaxone.
abstract: The incidence of ceftriaxone-related hypersensitivity skin reactions is between 1% and 3%, whereas anaphylaxis is rare. To the best of our knowledge, the following case is the first report of asystole after the administration of single-dose ceftriaxone. A 55-year-old man was admitted to our emergency department because of high fever, abdominal pain, dysuria, and weakness. To determine the cause of his fever, blood and urine cultures were obtained. Then, an infusion of 1 g ceftriaxone was started slowly. One minute later, cardiac arrest occurred. The rhythm was asystole. Cardiopulmonary resuscitation and tracheal intubation were performed immediately, and the ceftriaxone infusion was discontinued. Within 20 minutes, circulation was restored. The time of onset was suggestive of ceftriaxone-induced anaphylaxis. The patient was discharged in good clinical condition on the 10th day of admission. Emergency physicians should be mindful of the possibility of anaphylaxis and asystole that could occur with the first dose of ceftriaxone and should also make sure to offer receiving detailed informed patient consent, too.
authors.affiliation: Duzce University Medical Faculty, Department of Emergency Medicine, Duzce, Turkey. a_saritas_@hotmail.com
authors.forename: Ayhan
authors.initials: A
authors.lastname: Saritas
authors.forename: Mesut
authors.initials: M
authors.lastname: Erbas
authors.forename: Ibak
authors.initials: I
authors.lastname: Gonen
authors.forename: Melik
authors.initials: M
authors.lastname: Candar
authors.forename: Omur
authors.initials: O
authors.lastname: Ozturk
authors.forename: Hayati
authors.initials: H
authors.lastname: Kandis
authors.forename: Gulbin
authors.initials: G
authors.lastname: Sezen
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D016887:Cardiopulmonary Resuscitation; D002443:Ceftriaxone / Q000009:adverse effects*; D016757:Death, Sudden, Cardiac / Q000209:etiology; D004636:Emergency Service, Hospital; D006323:Heart Arrest / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000900:Anti-Bacterial Agents; D002443:Ceftriaxone