title: Pioneer GABA cells comprise a subpopulation of hub neurons in the developing hippocampus.
abstract: Connectivity in the developing hippocampus displays a functional organization particularly effective in supporting network synchronization, as it includes superconnected hub neurons. We have previously shown that hub network function is supported by a subpopulation of GABA neurons. However, it is unclear whether hub cells are only transiently present or later develop into distinctive subclasses of interneurons. These questions are difficult to assess given the heterogeneity of the GABA neurons and the poor early expression of markers. To circumvent this conundrum, we used "genetic fate mapping" that allows for the selective labeling of GABA neurons based on their place and time of origin. We show that early-generated GABA cells form a subpopulation of hub neurons, characterized by an exceptionally widespread axonal arborization and the ability to single-handedly impact network dynamics when stimulated. Pioneer hub neurons remain into adulthood, when they acquire the classical markers of long-range projecting GABA neurons.
authors.affiliation: Inserm Unité 901, Marseille 13009, France.
authors.forename: Michel Aimé
authors.initials: MA
authors.lastname: Picardo
authors.forename: Philippe
authors.initials: P
authors.lastname: Guigue
authors.forename: Paolo
authors.initials: P
authors.lastname: Bonifazi
authors.forename: Renata
authors.initials: R
authors.lastname: Batista-Brito
authors.forename: Camille
authors.initials: C
authors.lastname: Allene
authors.forename: Alain
authors.initials: A
authors.lastname: Ribas
authors.forename: Gord
authors.initials: G
authors.lastname: Fishell
authors.forename: Agnès
authors.initials: A
authors.lastname: Baude
authors.forename: Rosa
authors.initials: R
authors.lastname: Cossart
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001369:Axons / Q000378:metabolism / Q000648:ultrastructure; D019070:Cell Lineage; D005260:Female; D006624:Hippocampus / Q000166:cytology* / Q000254:growth & development* / Q000378:metabolism; D007395:Interneurons / Q000166:cytology / Q000502:physiology; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D055495:Neurogenesis / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D018408:Patch-Clamp Techniques; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D005680:gamma-Aminobutyric Acid