title: The toxin and antidote puzzle: new ways to control insect pest populations through manipulating inheritance.
abstract: Insects carry out essential ecological functions, such as pollination, but also cause extensive damage to agricultural crops, and transmit human diseases such as malaria and dengue fever. Advances in insect transgenesis are making it increasingly feasible to engineer genes conferring desirable phenotypes, and gene drive systems are required to spread these genes into wild populations. Medea provides one solution, being able to spread into a population from very low initial frequencies through the action of a maternally-expressed toxin linked to a zygotically-expressed antidote. Several other toxin-antidote combinations are imaginable that distort the offspring ratio in favor of a desired transgene, or drive the population towards an all-male crash. We explore two such systems--Semele, which is capable of spreading a desired transgene into an isolated population in a confined manner; and Merea, which is capable of inducing a local population crash when located on the Z chromosome of a Lepidopteron pest.
authors.affiliation: Division of Biology, California Institute of Technology, Pasadena, California, USA. johnmm@caltech.edu
authors.forename: John M
authors.initials: JM
authors.lastname: Marshall
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified / Q000235:genetics* / Q000378:metabolism*; D000931:Antidotes / Q000378:metabolism*; D001517:Coleoptera / Q000235:genetics / Q000378:metabolism; D005260:Female; D005854:Germ Cells / Q000378:metabolism; D006801:Humans; D007303:Insect Vectors / Q000235:genetics / Q000378:metabolism; D007313:Insecta / Q000235:genetics* / Q000378:metabolism*; D008288:Malaria / Q000469:parasitology / Q000517:prevention & control; D008297:Male; D010572:Pest Control, Biological; D010935:Plant Diseases / Q000469:parasitology; D013045:Species Specificity; D014118:Toxins, Biological / Q000235:genetics* / Q000378:metabolism
chemical_list: D000931:Antidotes; D014118:Toxins, Biological