title: Inflammation as a marker for the prediction of internal carotid artery restenosis following eversion endarterectomy--evidence from clinical studies.
abstract: The role of inflammation is well established in the pathogenesis of atherosclerosis and an increased level of circulating inflammatory markers may predict the future risk of atherosclerosis progression and plaque rupture. C-reactive protein (CRP) identification by hypersensitive methods (high-sensitivity CRP [hsCRP]) has become a clinical and laboratory inflammation marker. Carotid endarterectomy (CEA) is a well-established procedure for carotid stenosis treatment which can reduce stroke rate. Internal carotid artery (ICA) restenosis reduction may be prevented by the anti-inflammatory effect of statins. This review considers the recent findings on the presence of hsCRP and C3 complement concentration and inflammatory plaque composition as well as their effects on ICA restenosis rate, following eversion CEA with emphasis on human studies.
authors.affiliation: Department of Vascular Surgery, Dedinje Cardiovascular Institute, Belgrade University School of Medicine, Belgrade, Serbia.
authors.forename: Slobodan
authors.initials: S
authors.lastname: Tanaskovic
authors.forename: Esma R
authors.initials: ER
authors.lastname: Isenovic
authors.forename: Djordje
authors.initials: D
authors.lastname: Radak
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism*; D002343:Carotid Artery, Internal; D016893:Carotid Stenosis / Q000097:blood* / Q000473:pathology* / Q000601:surgery; D003176:Complement C3 / Q000378:metabolism*; D016894:Endarterectomy, Carotid; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000473:pathology / Q000517:prevention & control; D011237:Predictive Value of Tests; D012008:Recurrence
chemical_list: D003176:Complement C3; D002097:C-Reactive Protein