title: Differences between dextroamphetamine and methamphetamine: behavioral changes and oxidative damage in brain of Wistar rats.
abstract: In this study methamphetamine (m-AMPH) and dextroamphetamine (d-AMPH) were compared to determine the potency of the two drugs on behavior and oxidative damage in brain of rats. Male adult Wistar rats were given single (acute administration) or repeated (chronic administration, 14 days) intraperitoneal injections of saline (0.9% NaCl), d-AMPH (2 mg/kg) or m-AMPH (0.25, 0.5, 1 or 2 mg/kg). Locomotor activity was evaluated in open-field apparatus 2 h after the last drug injection. Additionally, thiobarbituric acid reactive substances (TBARS) and protein carbonyl formation were measured in the prefrontal cortex, amygdala, hippocampus and striatum. In both experiments, d-AMPH and m-AMPH (all doses administered) increased the locomotor activity of animals, meantime, no significant difference between d-AMPH and m-AMPH was observed. d-AMPH and m-AMPH increased lipid and protein damage, but m-AMPH was more potent than d-AMPH, however, this effect varies depending on the brain region and the experimental protocol. The results of this study show that d-AMPH and m-AMPH have similar behavioral effects, which previous studies had already reported. On the other hand, this study demonstrated that the m-AMPH induces oxidative damage greater than d-AMPH, showing neurochemical differences previously unknown.
authors.affiliation: Laboratory of Neurosciences and National Institute for Translational Medicine (INCT-TM), Postgraduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC 88806-000, Brazil.
authors.forename: Dayane D
authors.initials: DD
authors.lastname: da-Rosa
authors.forename: Samira S
authors.initials: SS
authors.lastname: Valvassori
authors.forename: Amanda V
authors.initials: AV
authors.lastname: Steckert
authors.forename: Camila O
authors.initials: CO
authors.lastname: Arent
authors.forename: Camila L
authors.initials: CL
authors.lastname: Ferreira
authors.forename: Jéssica
authors.initials: J
authors.lastname: Lopes-Borges
authors.forename: Roger B
authors.initials: RB
authors.lastname: Varela
authors.forename: Edemilson
authors.initials: E
authors.lastname: Mariot
authors.forename: Felipe
authors.initials: F
authors.lastname: Dal-Pizzol
authors.forename: Monica L
authors.initials: ML
authors.lastname: Andersen
authors.forename: João
authors.initials: J
authors.lastname: Quevedo
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D000697:Central Nervous System Stimulants / Q000633:toxicity*; D003913:Dextroamphetamine / Q000633:toxicity*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects*; D008297:Male; D008694:Methamphetamine / Q000633:toxicity*; D009043:Motor Activity / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects*; D050050:Protein Carbonylation; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D013997:Time Factors
chemical_list: D000697:Central Nervous System Stimulants; D017392:Thiobarbituric Acid Reactive Substances; D008694:Methamphetamine; D003913:Dextroamphetamine