title: [Intensity-modulated radiation therapy for anal carcinoma].
abstract: Anal canal carcinoma are highly curable by irradiation, combined with chemotherapy in locally advanced disease, with preservation of sphincter function. The clinical target volume for the nodes is extended, often including the inguinal nodes, which is not usual for other pelvic tumours. Acute and late effects are correlated with the volume and dose delivered to organs at risk, i. e. small bowel, bladder and increased by concomitant chemotherapy. Intensity modulated irradiation (IMRT) makes it possible to optimize the dose distribution in this "complex U shaped" volume, while maintaining the dose distribution for the target volumes. The conversion from conformal irradiation to IMRT necessitates good knowledge of the definition and skills to delineate target volumes and organs at risk, including new volumes needed to optimize the dose distribution. Dosimetric and clinical benefits of IMRT are described, based on early descriptions and evidence-based publication. The growing development of IMRT in anal canal radiotherapy must be encouraged, and long-term benefits should be soon published. Radiation oncologists should precisely learn IMRT recommendations before starting the technique, and evaluate its early and late results for adverse effects, but also for long-term tumour control.
authors.affiliation: Département de radiothérapie, centre Alexis-Vautrin, 6, avenue de Bourgogne, 54511 Vandœuvre-lès-Nancy cedex, France. d.peiffert@nancy.unicancer.fr
authors.forename: D
authors.initials: D
authors.lastname: Peiffert
authors.forename: M-V
authors.initials: MV
authors.lastname: Moreau-Claeys
authors.forename: L
authors.initials: L
authors.lastname: Tournier-Rangeard
authors.forename: S
authors.initials: S
authors.lastname: Huger
authors.forename: V
authors.initials: V
authors.lastname: Marchesi
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001005:Anus Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D002277:Carcinoma / Q000188:drug therapy / Q000532:radiotherapy*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D006801:Humans; D015337:Multicenter Studies as Topic; D058958:Organs at Risk; D017410:Practice Guidelines as Topic; D011446:Prospective Studies; D020266:Radiotherapy, Conformal; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods; D012189:Retrospective Studies
chemical_list: D000970:Antineoplastic Agents