title: Accelerated healing with the use of a silk fibroin membrane for the guided bone regeneration technique.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the bone regeneration ability of silk fibroin (SF) membrane.
  
  
  METHODS
  Fourier-transform infrared (FT-IR) and solubility test against distilled water were performed with 3 different types of SF membrane (SM1, SM2, and SM3). Subsequently, microscopic computerized tomography (μ-CT) and histomorphometric analyses were performed in rabbit calvarial defect model after SF membrane application at 4 and 8 weeks after surgery.
  
  
  RESULTS
  FT-IR showed that the conformation of the SF membrane was a random coil structure and that SM1 was the least soluble. When SM1 was used in the animal model, the groups with SM1 had significantly higher new bone formation than the uncovered control in both the μ-CT and the histomorphometric analyses (P < .05).
  
  
  CONCLUSIONS
  The SF membrane had more new bone formation compared with the uncovered control.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Gangneung-Wonju National University, Gangneung, Republic of Korea.
authors.forename: Ji-Young
authors.initials: JY
authors.lastname: Song
authors.forename: Seong-Gon
authors.initials: SG
authors.lastname: Kim
authors.forename: Jong-Won
authors.initials: JW
authors.lastname: Lee
authors.forename: Weon-Sik
authors.initials: WS
authors.lastname: Chae
authors.forename: Haeyong
authors.initials: H
authors.lastname: Kweon
authors.forename: You-Young
authors.initials: YY
authors.lastname: Jo
authors.forename: Kwang-Gill
authors.initials: KG
authors.lastname: Lee
authors.forename: Yong-Chan
authors.initials: YC
authors.lastname: Lee
authors.forename: Je-Yong
authors.initials: JY
authors.lastname: Choi
authors.forename: Jwa-Young
authors.initials: JY
authors.lastname: Kim
mesh_terms: D000818:Animals; D012831:Bombyx; D015519:Bone Density / Q000502:physiology; D001847:Bone Diseases / Q000473:pathology / Q000601:surgery; D001857:Bone Matrix / Q000473:pathology; D001861:Bone Regeneration / Q000502:physiology*; D004801:Eosine Yellowish-(YS); D005240:Feasibility Studies; D005349:Fibroins / Q000737:chemistry; D005456:Fluorescent Dyes; D048091:Guided Tissue Regeneration / Q000379:methods*; D008567:Membranes, Artificial; D023421:Models, Animal; D010012:Osteogenesis / Q000502:physiology; D010294:Parietal Bone / Q000473:pathology / Q000601:surgery; D011487:Protein Conformation; D011817:Rabbits; D047011:Silk / Q000737:chemistry; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013997:Time Factors; D014867:Water / Q000737:chemistry; D014945:Wound Healing / Q000502:physiology; D055114:X-Ray Microtomography
chemical_list: D005456:Fluorescent Dyes; D008567:Membranes, Artificial; D047011:Silk; D014867:Water; D005349:Fibroins; D004801:Eosine Yellowish-(YS)