title: Lower limb-localized vascular phenomena explain initial orthostatic hypotension upon standing from squat.
abstract: The cause(s) of initial orthostatic hypotension (transient fall in blood pressure within 15 s upon active rising) have not been established. We tested the hypothesis that this hypotension is due to local vascular phenomena in contracting leg muscles from the brief effort of standing up. Seventeen young healthy subjects (2 male and 15 female, 22.5 ± 1.0 years) performed an active rise from resting squat after a 10-s squat, a 1-min squat, or a 5-min squat. Beat-by-beat arterial blood pressure, cardiac output, heart rate, and stroke volume (Finometer finger photoplethysmography) and right common femoral artery blood flow (Doppler and Echo ultrasound) were recorded. Data are means ± SE. Quiet standing before squat represented baseline. Peak increases in lower limb and total vascular conductance (ml·min(-1)·mmHg(-1)) upon standing were not different within squat conditions (10-s squat, 50.0 ± 12.4 vs. 44.3 ± 5.0; 1-min squat, 54.7 ± 9.2 vs. 50.5 ± 4.5; 5-min squat, 67.4 ± 13.7 vs. 58.8 ± 3.9; all P > 0.574). Mean arterial blood pressure (in mmHg) fell to a nadir well below standing baseline in all conditions despite increases in cardiac output. The hypotension predicted by the increase in leg vascular conductance accounted for this hypotension [observed vs. predicted (in mmHg): 10-s squat, -17.1 ± 2.1 vs. -18.3 ± 5.5; 1-min squat, -22.0 ± 3.8 vs. -25.3 ± 4.9; 5-min squat, -28.3 ± 4.0 vs. -29.2 ± 6.7]. We conclude that rapid contraction induced dilation in leg muscles with the effort of standing, along with a minor potential contribution of elevated lower limb arterio-venous pressure gradient, outstrips compensatory cardiac output responses and is the cause of initial orthostatic hypotension upon standing from squat.
authors.affiliation: Human Vascular Control Laboratory, School of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada. mt29@queensu.ca
authors.forename: Michael E
authors.initials: ME
authors.lastname: Tschakovsky
authors.forename: Kristine
authors.initials: K
authors.lastname: Matusiak
authors.forename: Catherine
authors.initials: C
authors.lastname: Vipond
authors.forename: Lisa
authors.initials: L
authors.lastname: McVicar
mesh_terms: D000704:Analysis of Variance; D017704:Baroreflex; D001783:Blood Flow Velocity; D001794:Blood Pressure; D002302:Cardiac Output; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006339:Heart Rate; D006801:Humans; D007024:Hypotension, Orthostatic / Q000209:etiology / Q000503:physiopathology*; D035002:Lower Extremity; D008297:Male; D009119:Muscle Contraction; D018482:Muscle, Skeletal / Q000098:blood supply* / Q000503:physiopathology; D017156:Photoplethysmography; D011187:Posture; D012039:Regional Blood Flow; D013997:Time Factors; D018608:Ultrasonography, Doppler; D018924:Vascular Capacitance; D014664:Vasodilation; D055815:Young Adult