title: Dramatic dietary fat reduction is feasible for breast cancer patients: Results of the randomised study, WINS (UK) - stage 1.
abstract: BACKGROUND
  The influence of dietary fat on breast tumour growth(1) and, more recently, on treatment outcomes,(2,3) suggests an important role for dietary advice in the future health of breast cancer patients. The Women's Intervention Nutrition Study (UK) - Stage 1 assessed the feasibility of achieving and maintaining a ≥ 50% reduction in reported fat intake in postmenopausal, early stage breast cancer patients in the UK.
  
  
  METHODS
  This study recruited patients in South-east England between 2000 and 2005. They were randomly allocated into two groups. Group 1 (n = 54), received specific dietary counselling to halve their reported fat intake and maintain this low fat intake. Group 2 (n = 53) received healthy eating advice only. Dietitian-led group sessions provided support for women in both groups over 2 years.(4) Validated four-day diaries were used to measure intake. Data analysis used Generalised Linear Model (GLM) for repeated measures and logistic regression.
  
  
  RESULTS
  A significantly greater proportion of women in Group 1 reported a fat intake reduction of ≥ 50% at 3 months (p < .001) and 24 months (p < .001) than in Group 2. The size of the effect of active dietary counselling was 37% at 3 months (95%CI: 21-54%) and 35% at 24 months (95%CI: 17-53%). Mean fat intake was halved at 3 months and 24 months in Group 1 only.
  
  
  CONCLUSIONS
  Demonstrating such feasibility is a key step towards defining diet's role in the secondary prevention of breast cancer.
authors.affiliation: WINS Research Team, Winchester and Andover Breast Unit, Royal Hampshire County Hospital, Winchester SO22 5DG, United Kingdom. barbara.parry@wehct.nhs.uk
authors.forename: B M
authors.initials: BM
authors.lastname: Parry
authors.forename: J M
authors.initials: JM
authors.lastname: Milne
authors.forename: G
authors.initials: G
authors.lastname: Yadegarfar
authors.forename: R M
authors.initials: RM
authors.lastname: Rainsbury
mesh_terms: D000367:Age Factors; D000368:Aged; D001943:Breast Neoplasms / Q000178:diet therapy* / Q000401:mortality / Q000473:pathology; D016001:Confidence Intervals; D004032:Diet; D018752:Diet, Fat-Restricted; D018572:Disease-Free Survival; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016014:Linear Models; D016015:Logistic Models; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D018570:Risk Assessment; D016019:Survival Analysis; D016896:Treatment Outcome; D006113:United Kingdom