title: A facile one-pot sonochemical synthesis of surface-coated mannosyl protein microspheres for detection and killing of bacteria.
abstract: We report a remarkably facile one-pot sonochemical approach to prepare protein microspheres whose shells are covalently decorated with a mannosyl derivative to target Escherichia coli (E. coli), while their cores are encapsulated with tetracycline. Conjugated microspheres induced the agglutination of E. coli and increased the anti-bacterial activity of the encapsulated tetracycline by five fold.
authors.affiliation: Department of Chemistry, Bar-Ilan University, Ramat-Gan 52900, Israel.
authors.forename: Natalia
authors.initials: N
authors.lastname: Skirtenko
authors.forename: Michal
authors.initials: M
authors.lastname: Richman
authors.forename: Yeshayahu
authors.initials: Y
authors.lastname: Nitzan
authors.forename: Aharon
authors.initials: A
authors.lastname: Gedanken
authors.forename: Shai
authors.initials: S
authors.lastname: Rahimipour
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002417:Cattle; D004220:Disulfides / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects; D008358:Mannose / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry; D013752:Tetracycline / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D004220:Disulfides; D011506:Proteins; D012710:Serum Albumin, Bovine; D013752:Tetracycline; D008358:Mannose