title: Detours on the road to diagnosis of Graves disease.
abstract: OBJECTIVE
  The aims of this study were to determine the frequency at which spurious diagnoses and unnecessary treatment occurs prior to the diagnosis of Graves disease (GD) and to evaluate the economic consequences of these events.
  
  
  METHODS
  Retrospective chart review of children diagnosed with GD.
  
  
  RESULTS
  A total of 76 children (61 girls) aged 11.9 ± 3.8 years were identified. In all, 17 (22.4%) were referred to other subspecialists prior to diagnosis of GD. Six were hospitalized, and 2 visited emergency rooms. A total of 15 (19.7%) underwent nonthyroid-related studies. Estimated cost of testing and procedures ranged from $49 to $14,000. Twelve (15.8%) were diagnosed with attention deficit/hyperactivity disorder, and 16 (21.1%) were started on medications for other conditions prior to diagnosis of GD.
  
  
  CONCLUSIONS
  Evaluation and treatment for presumed other disorders are common in children with GD. A high index of suspicion for hyperthyroidism by primary care providers may help to avoid clinical detours that may be costly and delay diagnosis.
authors.affiliation: Riley Hospital for Children, Indianapolis, IN 46202, USA. eksims@iupui.edu
authors.forename: Emily K
authors.initials: EK
authors.lastname: Sims
authors.forename: Erica A
authors.initials: EA
authors.lastname: Eugster
authors.forename: Todd D
authors.initials: TD
authors.lastname: Nebesio
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D057210:Delayed Diagnosis / Q000191:economics / Q000706:statistics & numerical data*; D003937:Diagnosis, Differential; D003951:Diagnostic Errors / Q000191:economics / Q000706:statistics & numerical data*; D005260:Female; D006111:Graves Disease / Q000175:diagnosis*; D017048:Health Care Costs; D006801:Humans; D007196:Indiana; D008297:Male; D012189:Retrospective Studies