title: Antigenotoxic ketosteroid from the red algae Jania adhaerens.
abstract: A new ketosteroid, 6β,16β-dihydroxycholest-4-en-3-one (1), in addition to the known 6β-hydroxycholest-4-en-3-one (2), 6β-hydroxycholest-4,22-dien-3-one (3) and 16β-hydroxy-5α-cholestan-3,6-dione (4), was isolated from the red alga Jania adhaerens. The structures were assigned on the basis of (1)H- and (13)C-NMR experiments. The new compound (1) was evaluated for its genotoxic and cytotoxic activities and found to possess protective antigenotoxicity in human peripheral blood cells.
authors.affiliation: Department of Marine Chemistry, Faculty of Marine Sciences, King Abdulaziz University, PO Box 80207, Jeddah 21589, Saudi Arabia.
authors.forename: Walied M
authors.initials: WM
authors.lastname: Alarif
authors.forename: Seif-Eldin N
authors.initials: SE
authors.lastname: Ayyad
authors.forename: Sufian M
authors.initials: SM
authors.lastname: El-Assouli
authors.forename: Sultan S
authors.initials: SS
authors.lastname: Al-Lihaibi
mesh_terms: D016587:Antimutagenic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D020552:Comet Assay; D004249:DNA Damage; D004912:Erythrocytes / Q000187:drug effects; D066298:In Vitro Techniques; D007664:Ketosteroids / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D000461:Rhodophyta / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
chemical_list: D016587:Antimutagenic Agents; D007664:Ketosteroids