title: Nutritional control of cell growth via TOR signaling in budding yeast.
abstract: Cell growth is highly regulated and its deregulation is related to many human diseases such as cancer. Nutritional cues stimulate cell growth through modulation of TOR (target of rapamycin) signaling pathway. At the center of this pathway is a large serine/threonine protein kinase TOR, which forms two distinct functional complexes TORC1 and TORC2 in a cell. TORC1 senses the environmental nutrient quality/quantity and transmits the growth signals to multiple effectors to regulate a broad spectrum of biological processes including translation initiation, ribosome biogenesis, autophagy, nutrient uptake, and metabolism. By using budding yeast as a model, recent studies began to elucidate the complexity of the TOR signaling pathway.
authors.affiliation: Graduate Program in Cellular and Molecular Pharmacology, Department of Pharmacology, Cancer Institute of New Jersey, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ, USA.
authors.forename: Yuehua
authors.initials: Y
authors.lastname: Wei
authors.forename: X F Steven
authors.initials: XF
authors.lastname: Zheng
mesh_terms: D049109:Cell Proliferation; D010442:Peptide Chain Initiation, Translational; D012270:Ribosomes / Q000378:metabolism; D004718:Saccharomycetales / Q000166:cytology* / Q000201:enzymology* / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: D058570:TOR Serine-Threonine Kinases