title: Therapeutic targeting of B7-H1 in breast cancer.
abstract: BACKGROUND
  Breast cancer is the most common form of malignancy occurring in women worldwide. B7-H1 is a co-inhibitory molecule expressed by several types of tumors, including breast cancer. The aberrant expression of B7-H1 in breast cancer cells has been determined, its role in recruiting regulatory T cells into the tumor microenvironment has been elucidated and a strong link to B7-H1 induction in highly proliferative breast cancer has been provided. It has also been demonstrated that doxorubicin, a drug commonly used for breast cancer treatment, downregulates the cell surface expression of B7-H1 and upregulates its nuclear expression, which therefore suggests an anti-apoptotic role of B7-H1 in breast cancer.
  
  
  METHODS
  This review illustrates the various factors involved in the induction of B7-H1 and its role in immune evasion and chemoresistance. It also provides potential therapeutic strategies for targeting B7-H1 in breast cancer.
  
  
  CONCLUSIONS
  B7-H1 should be considered as a potential therapeutic target for breast cancer. Indeed, there is increasing evidence for the potential efficacy of B7-H1 blockade in the prevention of immune evasion by cancer cells. Additionally, B7-H1 targeting can be used in conjunction with other therapeutic modalities for improved efficacy and reduced toxicity. We expect that B7-H1 blockade in combination with other therapeutics will be a prime therapeutic strategy in the future.
authors.affiliation: Dasman Diabetes Institute , Immunology & Innovative Cell Therapy Unit , Department of Biomedical Research , Dasman , Kuwait.
authors.forename: Amal
authors.initials: A
authors.lastname: Hasan
authors.forename: Hazem
authors.initials: H
authors.lastname: Ghebeh
authors.forename: Cynthia
authors.initials: C
authors.lastname: Lehe
authors.forename: Rasheed
authors.initials: R
authors.lastname: Ahmad
authors.forename: Said
authors.initials: S
authors.lastname: Dermime
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000276:immunology; D060890:B7-H1 Antigen / Q000276:immunology*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D019139:Tumor Escape
chemical_list: D060890:B7-H1 Antigen; C423236:CD274 protein, human