title: Endothelial mesenchymal transformation mediated by IL-1β-induced FGF-2 in corneal endothelial cells.
abstract: This review describes the molecular mechanism of endothelial mesenchymal transformation (EMT) mediated by fibroblast growth factor-2 (FGF-2) in corneal endothelial cells (CECs). Corneal fibrosis is not frequently observed in corneal endothelium/Descemet's membrane complex; but when this pathologic tissue is produced, it causes a loss of vision by physically blocking light transmittance. Herein, we will address the cellular activities of FGF-2 and its signaling pathways during the EMT process. Furthermore, we will discuss the role of inflammation on FGF-2-mediated EMT. Interleukin-1β (IL-1β) greatly upregulates FGF-2 production in CECs, thus leading to FGF-2-mediated EMT; the whole spectrum of the injury-mediated inflammation (IL-1β pathway) and the subsequent EMT process (FGF-2 pathway) will be briefly discussed. Intervention in the two pathways will provide the means to block EMT before inflammation causes an irreversible change, such as the production of retrocorneal fibrous membrane observed in human eyes.
authors.affiliation: Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
authors.forename: Jeong Goo
authors.initials: JG
authors.lastname: Lee
authors.forename: MinHee K
authors.initials: MK
authors.lastname: Ko
authors.forename: EunDuck P
authors.initials: EP
authors.lastname: Kay
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism; D000818:Animals; D048430:Cell Shape; D024042:Collagen Type I / Q000378:metabolism; D003315:Cornea / Q000098:blood supply*; D003316:Corneal Diseases / Q000378:metabolism* / Q000473:pathology; D042783:Endothelial Cells / Q000378:metabolism* / Q000473:pathology; D058750:Epithelial-Mesenchymal Transition; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism*; D005355:Fibrosis; D006801:Humans; D053583:Interleukin-1beta / Q000378:metabolism*; D008938:Mitosis; D058539:Phosphatidylinositol 3-Kinase / Q000378:metabolism; D015398:Signal Transduction; D015854:Up-Regulation
chemical_list: D024042:Collagen Type I; D053583:Interleukin-1beta; D016222:Fibroblast Growth Factor 2; D058539:Phosphatidylinositol 3-Kinase