title: Imidazole-modified porphyrin as a pH-responsive sensitizer for cancer photodynamic therapy.
abstract: 5,10,15,20-Tetrakis(N-(2-(1H-imidazol-4-yl)ethyl)benzamide)porphyrin produced twice as many singlet oxygen ((1)O(2)) molecules at pH 5.0 (quantum yield 0.53 ± 0.01) than at pH 7.4, whereas the (1)O(2) quenching rate was reduced by a factor of 2.5 for a pH change from 7.4 to 5.0.
authors.affiliation: Department of Chemistry and Biochemistry, Jackson State University, Jackson, MS 39211, USA.
authors.forename: Xianchun
authors.initials: X
authors.lastname: Zhu
authors.forename: Wentong
authors.initials: W
authors.lastname: Lu
authors.forename: Yazhou
authors.initials: Y
authors.lastname: Zhang
authors.forename: Aisha
authors.initials: A
authors.lastname: Reed
authors.forename: Brandon
authors.initials: B
authors.lastname: Newton
authors.forename: Zhen
authors.initials: Z
authors.lastname: Fan
authors.forename: Hongtao
authors.initials: H
authors.lastname: Yu
authors.forename: Paresh C
authors.initials: PC
authors.lastname: Ray
authors.forename: Ruomei
authors.initials: R
authors.lastname: Gao
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000577:Amides / Q000737:chemistry; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002264:Carboxylic Acids / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000737:chemistry*; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011166:Porphyrins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D026082:Singlet Oxygen / Q000737:chemistry
chemical_list: C568812:5,10,15,20-tetrakis(N-(2-(1H-imidazol-4-yl)ethyl)benzamide)porphyrin; D000577:Amides; D002264:Carboxylic Acids; D007093:Imidazoles; D017319:Photosensitizing Agents; D011166:Porphyrins; D026082:Singlet Oxygen