title: [Digital ulcers in systemic sclerosis].
abstract: Digital ulcers occur in up to 50% of patients with limited or diffuse systemic sclerosis. The lesions are extremely painful leading to substantial functional disability, local infection susceptibility and can escalate to gangrene and amputation. Underlying vasculopathy and angiopathy cause obliteration of digital arteries and ischemic tissue changes. Management of digital ulcers includes non-pharmacological and pharmacological modalities. Early diagnosis in preclinical phase would enable preventive treatment prior to irreversible changes.
authors.affiliation: Klinicki odjel za imunologiju i alergologiju, Josipa Huttlera 4, 31000 Osijek.
authors.forename: Visnja
authors.initials: V
authors.lastname: Prus
mesh_terms: D005385:Fingers; D006801:Humans; D012595:Scleroderma, Systemic / Q000150:complications*; D012867:Skin / Q000098:blood supply; D012883:Skin Ulcer / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy