title: Clonal dissemination of Klebsiella pneumoniae ST258 harbouring KPC-2 in Argentina.
abstract: The present work describes the abrupt emergence of Klebsiella pneumoniae carbapenemase (KPC) and characterizes the first 79 KPC-producing enterobacteria from Argentina (isolated from 2006 to 2010). The emergence of bla(KPC-2) was characterized by two patterns of dispersion: the first was the sporadic occurrence in diverse enterobacteria from distant geographical regions, harbouring plasmids of different incompatibility groups and bla(KPC-2) in an unusual genetic environment flanked by ISKpn8-Δbla(TEM-1) and ISKpn6-like. bla(KPC-2) was associated with IncL/M transferable plasmids; the second was the abrupt clonal spread of K. pneumoniae ST258 harbouring bla(KPC-2) in Tn4401a.
authors.affiliation: Servicio Antimicrobianos, Instituto Nacional de Enfermedades Infecciosas (INEI)-ANLIS Dr Carlos G. Malbrán, Ciudad Autónoma de Buenos Aires, Argentina. gomez@anlis.gov.ar
authors.forename: S A
authors.initials: SA
authors.lastname: Gomez
authors.forename: F G
authors.initials: FG
authors.lastname: Pasteran
authors.forename: D
authors.initials: D
authors.lastname: Faccone
authors.forename: N
authors.initials: N
authors.lastname: Tijet
authors.forename: M
authors.initials: M
authors.lastname: Rapoport
authors.forename: C
authors.initials: C
authors.lastname: Lucero
authors.forename: O
authors.initials: O
authors.lastname: Lastovetska
authors.forename: E
authors.initials: E
authors.lastname: Albornoz
authors.forename: M
authors.initials: M
authors.lastname: Galas
authors.forename: R G
authors.initials: RG
authors.lastname: Melano
authors.forename: A
authors.initials: A
authors.lastname: Corso
authors.forename: A
authors.initials: A
authors.lastname: Petroni
mesh_terms: D001118:Argentina / Q000453:epidemiology; D015373:Bacterial Typing Techniques; D003227:Conjugation, Genetic; D004251:DNA Transposable Elements; D004754:Enterobacter / Q000235:genetics; D005798:Genes, Bacterial; D006761:Hospitals; D006801:Humans; D007710:Klebsiella Infections / Q000453:epidemiology* / Q000382:microbiology / Q000635:transmission; D007711:Klebsiella pneumoniae / Q000145:classification / Q000201:enzymology / Q000235:genetics* / Q000302:isolation & purification; D058885:Multilocus Sequence Typing; D010957:Plasmids / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D004251:DNA Transposable Elements; D001618:beta-Lactamases; C547585:beta-lactamase KPC-2, Klebsiella pneumoniae