title: [Noninvasive radiodiagnosis of left ventricular diastolic dysfunction in hypertensive patients].
abstract: To define the informative value of Doppler studies in the early diagnosis of left ventricular (LV) diastolic dysfunction in patients with hypertensive disease (HD), the authors examined 74 patients with grade 1-2 HD, including 65 men and 9 women aged 43 to 63 years. All the patients underwent echocardiography (echoCG), Doppler echoCG (DechoCG), tissue DechoCG (TDechoCG), and treadmill. According to the echoCG LV mass index (LVMI), all the patients were divided into 2 groups: 1) 33 patients with increased LVMI and 2) 41 with normal LVMI. A control group consisted of 20 apparently healthy patients. Groups 1 and 2 showed a preponderance of patients with concentric LV hypertrophy (CLVH) and those with concentric LV remodeling, respectively. In accordance with DechoCG, the signs of primary LV diastolic dysfunction ((E/A = 0.8+/-0.1; IVRT = 103+/-15) were found only in Group 1 patients. TDechoCG displayed the signs of primary LV diastolic dysfunction in both groups (e'<a'; e'/a'<1). The E/e'ratio was significantly increased in Group 1i (p < 0.01).
  
  
  CONCLUSIONS
  1. DechoCG fails to reveal the initial signs of LV diastolic dysfunction. 2. The combined use of Doppler studies permits the initial signs of LV diastolic dysfunction to be detected in patients with HD. 3. In hypertensive disease patients with CLVH, as evidenced by echoCG, the higher E/e'> or =10 ratio, suggests elevated LV filling pressure as an early stage of diastolic dysfunction.
authors.forename: O A
authors.initials: OA
authors.lastname: Alekseeva
authors.forename: N N
authors.initials: NN
authors.lastname: Mikheev
mesh_terms: D000328:Adult; D003971:Diastole; D015150:Echocardiography, Doppler; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology*; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D020257:Ventricular Remodeling