title: Investigation of vasculogenic mimicry in intracranial hemangiopericytoma.
abstract: Vasculogenic mimicry (VM) has increasingly been recognized as a form of angiogenesis. Previous studies have shown that the existence of VM is associated with poor clinical prognosis in certain malignant tumors. However, whether VM is present and clinically significant in intracranial hemangiopericytoma (HPC) is unknown. The present study was therefore designed to examine the expression of VM in intracranial HPC and its correlation with matrix metalloprotease-2 (MMP-2) and vascular endothelial growth factor (VEGF). A total of 17 intracranial HPC samples, along with complete clinical and pathological data, were collected for our study. Immunohistochemistry was performed to stain tissue sections for CD34, periodic acid-Schiff, VEGF and MMP-2. The levels of VEGF and MMP-2 were compared between tumor samples with and without VM. The results showed that VM existed in 12 of 17 (70.6%) intracranial HPC samples. The presence of VM in tumors was associated with tumor recurrence (P<0.05) and expression of MMP-2 (P<0.05). However, there was no difference in the expression of VEGF between groups with and without VM.
authors.affiliation: Department of Neurosurgery, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, PR China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhang
authors.forename: Yun
authors.initials: Y
authors.lastname: Han
authors.forename: Keke
authors.initials: K
authors.lastname: Zhang
authors.forename: Liangzhu
authors.initials: L
authors.lastname: Teng
mesh_terms: D018952:Antigens, CD34 / Q000378:metabolism; D005260:Female; D006393:Hemangiopericytoma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000473:pathology*; D010503:Periodic Acid-Schiff Reaction; D019292:Skull Base Neoplasms / Q000378:metabolism / Q000473:pathology*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D018952:Antigens, CD34; D042461:Vascular Endothelial Growth Factor A; D020778:Matrix Metalloproteinase 2