title: The efficacy of oral brush biopsy with computer-assisted analysis in identifying precancerous and cancerous lesions.
abstract: BACKGROUND
  Cancer of the oral cavity is the sixth most common malignancy reported worldwide and one with the highest mortality rate among all malignancies. There is a paucity of reliable diagnostic methods to detect early malignancies. This study was performed to evaluate the sensitivity and specificity of brush biopsy in identifying oral premalignant and malignant lesions.
  
  
  METHODS
  Oral brush and scalpel biopsies were performed on 85 consecutive patients presenting with an oral lesion deemed to be minimally suspicious by clinical examination and the results were compared.
  
  
  RESULTS
  Of 79 patients with adequate brush biopsy samples with matching scalpel biopsies, 27 revealed histopathologic evidence of dysplasia or carcinoma, 26 of which were independently identified with the oral brush biopsy (sensitivity: 96.3%-95% CI, 87%-100%). 52 oral lesions did not reveal any histopathologic evidence of dysplasia or carcinoma and of these, brush biopsy reported 47 as "negative" and 5 as "atypical"(specificity of "positive" brush biopsy result is 100%- 95% CI, 93%-100%; specificity for "atypical" brush biopsy result is 90.4%-95% CI, 82%-97%. The positive predictive value of an abnormal oral brush biopsy was 84% and the negative predictive value was 98%.
  
  
  CONCLUSIONS
  Our study demonstrated that the oral brush biopsy is an accurate test in identifying oral premalignant and malignant lesions, even if minimally suspicious.
authors.affiliation: Department of Pathology, Moti Lal Nehru Medical College, Lowther Road, Allahabad, 211001 India. rm8509@rediffmail.com
authors.forename: Ravi
authors.initials: R
authors.lastname: Mehrotra
authors.forename: Sanjay
authors.initials: S
authors.lastname: Mishra
authors.forename: Mamta
authors.initials: M
authors.lastname: Singh
authors.forename: Mangal
authors.initials: M
authors.lastname: Singh
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy / Q000379:methods* / Q000592:standards; D003936:Diagnosis, Computer-Assisted; D055088:Early Detection of Cancer / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000473:pathology*; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000473:pathology*; D011230:Precancerous Conditions / Q000175:diagnosis / Q000473:pathology*; D011446:Prospective Studies