title: Indoleamine 2,3-dioxygenase expression is associated with chronic rhinosinusitis with nasal polyps and antrochoanal polyps.
abstract: Chronic rhinosinusitis without and with nasal polyps (CRSwNP and CRSsNP), and antrochoanal polyps are different phenotypes with different pathomechanisms. Indoleamine 2,3-dioxygenase (IDO) is an enzyme expressed in many cells involved in the catabolism of the essential amino acid tryptophan to kynurenine. IDO might have a role in allergic airway inflammation. The aim was to evaluate if IDO expression is associated with CRSsNP, CRSwNP, or ACP. One hundred fifty specimens from the nasal cavity and sinus mucosa were immunohistochemically stained with mAb anti-IDO. The expression of epithelial and leukocyte IDO was associated with CRSwNP and ACP. The presence of ASA intolerance, asthma, atopy, smoking and use of medication did not significantly change the results. The different expression of IDO could putatively indicate the differences in the pathomechanisms of CRSsNP, CRSwNP and ACP. Further studies on the role of IDO in upper airways pathologies are required.
authors.affiliation: Department of Pathology, University of Tampere, Tampere, Finland.
authors.forename: T
authors.initials: T
authors.lastname: Honkanen
authors.forename: A
authors.initials: A
authors.lastname: Luukkainen
authors.forename: M
authors.initials: M
authors.lastname: Lehtonen
authors.forename: T
authors.initials: T
authors.lastname: Paavonen
authors.forename: J
authors.initials: J
authors.lastname: Karjalainen
authors.forename: M
authors.initials: M
authors.lastname: Hurme
authors.forename: J
authors.initials: J
authors.lastname: Myller
authors.forename: H
authors.initials: H
authors.lastname: Huhtala
authors.forename: M
authors.initials: M
authors.lastname: Rautiainen
authors.forename: S
authors.initials: S
authors.lastname: Toppila-Salmi
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D015897:Comorbidity; D004804:Eosinophils / Q000378:metabolism; D005260:Female; D006801:Humans; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000453:epidemiology* / Q000503:physiopathology; D012220:Rhinitis / Q000453:epidemiology* / Q000378:metabolism* / Q000503:physiopathology; D012852:Sinusitis / Q000453:epidemiology* / Q000378:metabolism* / Q000503:physiopathology; D055815:Young Adult
chemical_list: D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase