title: A clinical comparison of remifentanil or alfentanil in propofol-anesthetized cats undergoing ovariohysterectomy.
abstract: Sixteen cats were used to compare the cardiovascular and anesthetic effects of remifentanil (REMI) or alfentanil (ALF) in propofol-anesthetized cats undergoing ovariohysterectomy. After premedication with acepromazine, anesthesia was induced and maintained with a constant rate infusion of propofol (0.3 mg/kg/min). REMI or ALF infusions were administered simultaneously with propofol. Heart rate (HR), systolic arterial pressure (SAP), pulse oximetry (SpO(2)), rectal temperature (RT), and response to surgical stimulation were recorded at predefined time points during anesthesia. Data [mean±standard deviation (SD)] were analyzed by analysis of variance (ANOVA) for repeated measures followed by a Dunnett's test and Student t-test (P<0.05). SAP was significantly lower in ALF group than in REMI group. Extubation time was significantly shorter in REMI than in ALF group. Overall infusion rate of REMI and ALF was 0.24±0.05 μg/kg/min and 0.97±0.22 μg/kg/min, respectively. The combination of propofol and REMI or ALF provided satisfactory anesthesia in cats undergoing ovariohysterectomy.
authors.affiliation: Department of Veterinary Surgery and Anesthesiology, School of Veterinary Medicine and Animal Science, Sao Paulo State University, UNESP, Botucatu, Brazil.
authors.forename: Samanta T
authors.initials: ST
authors.lastname: Padilha
authors.forename: Paulo V M
authors.initials: PV
authors.lastname: Steagall
authors.forename: Beatriz P
authors.initials: BP
authors.lastname: Monteiro
authors.forename: Marcia A P
authors.initials: MA
authors.lastname: Kahvegian
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Ubukata
authors.forename: Edilberto O
authors.initials: EO
authors.lastname: Rodrigues
authors.forename: Andre Leguthe
authors.initials: AL
authors.lastname: Rosa
authors.forename: Antonio J A
authors.initials: AJ
authors.lastname: Aguiar
mesh_terms: D015760:Alfentanil / Q000008:administration & dosage*; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D000762:Anesthesia Recovery Period; D000771:Anesthesia, Intravenous / Q000662:veterinary*; D000818:Animals; D002415:Cats; D005260:Female; D007044:Hysterectomy / Q000662:veterinary*; D008991:Monitoring, Physiologic / Q000662:veterinary; D010052:Ovariectomy / Q000662:veterinary*; D010880:Piperidines / Q000008:administration & dosage*; D015742:Propofol / Q000008:administration & dosage; D000077208:Remifentanil
chemical_list: D000701:Analgesics, Opioid; D010880:Piperidines; D015760:Alfentanil; D000077208:Remifentanil; D015742:Propofol