title: Miscellaneous terpenoid constituents of Abies nephrolepis and their moderate cytotoxic activities.
abstract: Three monoterpenoids and two triterpenoids were isolated from Abies nephrolepis together with 53 known terpenoids. The structures of the compounds were established by 1D and 2D NMR spectroscopy. The absolute configuration of 3-hydroxycamphane-2-carboxylic acid was established as (1S,2R,3S,4R) by Cu-Kα X-ray crystallography. All 58 isolates were tested for cytotoxic activity against four tumor cells viz. A549 (human lung adenocarcinoma), Colo205 (colon adenocarcinoma), QGY-7703 (human hepatoma) and THP-1 (human monocytic leukemia). α-Cadinol exhibited the best effects on A549, Colo205 and QGY-7703 with IC(50) values of 8.6, 8.1 and 4.6 μg/mL, respectively.
authors.affiliation: Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
authors.forename: Dan-Wei
authors.initials: DW
authors.lastname: Ou-Yang
authors.forename: Liang
authors.initials: L
authors.lastname: Wu
authors.forename: Yong-Li
authors.initials: YL
authors.lastname: Li
authors.forename: Pei-Ming
authors.initials: PM
authors.lastname: Yang
authors.forename: De-Yun
authors.initials: DY
authors.lastname: Kong
authors.forename: Xian-Wen
authors.initials: XW
authors.lastname: Yang
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D028202:Abies / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D001892:Camphanes / Q000737:chemistry / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D013729:Terpenes / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001892:Camphanes; D010936:Plant Extracts; D013729:Terpenes; C445364:cadinol