title: Group of serum inflammatory markers and periodontitis-metabolic syndrome coexistence in Koreans.
abstract: BACKGROUND
  Recent epidemiologic studies have shown that individuals with periodontitis have a significantly increased risk of metabolic syndrome (MetS). Chronic infection and subsequent production of systemic inflammatory markers may be associated with this increased risk. The aim of present study is to determine whether the presence of periodontitis and MetS is associated with a group or an individual of C-reactive protein (CRP), interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor-α (TNF-α), and homocysteine (HCY) in the serum of a Korean population.
  
  
  METHODS
  Medical and periodontal parameters, including CRP, IL-1β, IL-6, IL-8, TNF-α, and HCY, were evaluated in 118 individuals (73 healthy; 20 with periodontitis only; 13 with MetS only; and 12 with both). The community periodontal index was used to assess periodontitis. Age, sex, monthly household income, smoking, and drinking were evaluated as confounders. Analysis of covariance, linear regression analysis, and factor analysis were applied.
  
  
  RESULTS
  The group of serologic cytokines was synergistically associated with the periodontitis-MetS coexistence. TNF-α and IL-6 were two representing serologic cytokines in the group.
  
  
  CONCLUSIONS
  Our results suggest that a group of systemic biologic markers represented by TNF-α and IL-6 might mediate the association between MetS and periodontitis adjusted for various confounders. Additional evidence is needed to generalize our results more widely.
authors.affiliation: Department of Preventive and Social Dentistry, Seoul National University, Seoul, Korea.
authors.forename: Dong-Hun
authors.initials: DH
authors.lastname: Han
authors.forename: Hye-Sun
authors.initials: HS
authors.lastname: Shin
authors.forename: Mi-Sun
authors.initials: MS
authors.lastname: Kim
authors.forename: Domyung
authors.initials: D
authors.lastname: Paek
authors.forename: Hyun-Duck
authors.initials: HD
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D002097:C-Reactive Protein / Q000032:analysis; D003430:Cross-Sectional Studies; D005163:Factor Analysis, Statistical; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D007723:Korea; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications*; D008875:Middle Aged; D010518:Periodontitis / Q000097:blood* / Q000150:complications*; D012044:Regression Analysis; D012959:Socioeconomic Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D055815:Young Adult
chemical_list: D018836:Inflammation Mediators; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D006710:Homocysteine; D002097:C-Reactive Protein