title: The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation.
abstract: Ubiquitylation (also known as ubiquitination) regulates essentially all of the intracellular processes in eukaryotes through highly specific modification of numerous cellular proteins, which is often tightly regulated in a spatial and temporal manner. Although most often associated with proteasomal degradation, ubiquitylation frequently serves non-proteolytic functions. In light of its central roles in cellular regulation, it has not been surprising to find that many of the components of the ubiquitin system itself are regulated by ubiquitylation. This observation has broad implications for pathophysiology.
authors.affiliation: Laboratory of Protein Dynamics and Signalling, National Cancer Institute, Frederick, Maryland 21702, USA. amw@nih.gov
authors.forename: Allan M
authors.initials: AM
authors.lastname: Weissman
authors.forename: Nitzan
authors.initials: N
authors.lastname: Shabek
authors.forename: Aaron
authors.initials: A
authors.lastname: Ciechanover
mesh_terms: D000818:Animals; D020387:Food Chain; D006801:Humans; D008954:Models, Biological; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism* / Q000502:physiology; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D025801:Ubiquitin / Q000378:metabolism*; D054875:Ubiquitination / Q000502:physiology*; D014925:Wit and Humor as Topic
chemical_list: D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex