title: Effects of iopamidol-370 versus iodixanol-320 on coronary contrast, branch depiction, and heart rate variability in dual-source coronary MDCT angiography.
abstract: OBJECTIVE
  The purpose of this article is to assess whether iopamidol-370 provides superior vascular contrast of the coronaries and depiction of anatomic detail without affecting heart rate and beat-to-beat variability during coronary dual-source MDCT compared with iodixanol-320.
  
  
  METHODS
  In this prospective trial, coronary CT angiography was performed on 60 adult patients using either iopamidol-370 or iodixanol-320. Cohorts were matched by age, habitus, sex, and baseline heart rate, with cohort sizes determined by power analysis. All studies were performed on a dual-source MDCT scanner with retrospective ECG-gating utilizing automatic pitch adjustment. Data assessment focused on heart rate variability during contrast administration statistically evaluated as Student t test comparisons within and between cohorts, coronary contrast-to-noise ratio analysis of the main coronary arteries utilizing Student t test comparisons between cohorts, and coronary branch depiction and distribution analysis in dual-reader consensus decisions between cohorts.
  
  
  RESULTS
  Thirty patients matched for age, habitus, sex, and heart rate were evaluated in each cohort. ECG analyses found a statistically significant (p = 0.013) decrease in heart rate during administration of iodixanol-320. Beat-to-beat variations, expressed as coefficient of variation, within and among cohorts were low (coefficient of variation, < 0.05). Contrast-to-noise ratio was significantly increased for iopamidol-370 versus iodixanol-320 (aortic root, p = 0.021; left main, p = 0.032; left anterior descending, p = 0.033; left circumflex, p = 0.039; and right, p = 0.009). Analysis of coronary branch visualization revealed improved depiction for iopamidol-370 compared with iodixanol-320.
  
  
  CONCLUSIONS
  Iopamidol-370, with its higher iodine concentration, provided greater vascular contrast of the arterial coronary tree and improved depiction of anatomic detail without significantly impacting cardiac heart rate during coronary MDCT imaging, as compared with iodixanol-320.
authors.affiliation: Department of Radiology, Duke University Medical Center, Erwin Rd, Box 3808, Durham, NC 27710, USA.
authors.forename: Jared D
authors.initials: JD
authors.lastname: Christensen
authors.forename: Laura T
authors.initials: LT
authors.lastname: Meyer
authors.forename: Lynne M
authors.initials: LM
authors.lastname: Hurwitz
authors.forename: Daniel T
authors.initials: DT
authors.lastname: Boll
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D055424:Cardiac-Gated Imaging Techniques / Q000379:methods*; D002637:Chest Pain / Q000000981:diagnostic imaging*; D003287:Contrast Media; D017023:Coronary Angiography / Q000379:methods*; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007479:Iopamidol; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed; D014283:Triiodobenzoic Acids
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; C044834:iodixanol; D007479:Iopamidol