title: B cells are resistant to immunomodulation by 'IVIg-educated' dendritic cells.
abstract: Intravenous immunoglobulin (IVIg) can exert beneficial effects in autoimmune and inflammatory diseases via several mutually non-exclusive mechanisms. While, IVIg can directly modulate the functions of both innate and adaptive immune cells such as dendritic cells (DC), macrophages, B and T cells, several reports have also highlighted that the regulation of immune responses by IVIg can be indirect. In view of these results, we aimed at exploring whether indirect regulation of immune cells by 'IVIg-educated' innate cells is a universal phenomenon. We addressed this question by deciphering the modulation of B cell functions by 'IVIg-educated' DC. Our results indicate that human B cells are resistant to immunomodulation by 'IVIg-educated' DC. However, IVIg at therapeutic concentrations can directly inhibit B cell activation and proliferation. These results thus suggest that, indirect modulation of immune cells by IVIg is not a universal phenomenon.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, Unité 872, 15 rue de l'Ecole de Médicine, Paris, France.
authors.forename: Mohan S
authors.initials: MS
authors.lastname: Maddur
authors.forename: Pushpa
authors.initials: P
authors.lastname: Hegde
authors.forename: Meenu
authors.initials: M
authors.lastname: Sharma
authors.forename: Srini V
authors.initials: SV
authors.lastname: Kaveri
authors.forename: Jagadeesh
authors.initials: J
authors.lastname: Bayry
mesh_terms: D056704:Adaptive Immunity; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000494:pharmacology; D015703:Antigens, CD / Q000032:analysis; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D015415:Biomarkers / Q000032:analysis; D002454:Cell Differentiation / Q000187:drug effects / Q000276:immunology; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D018920:Coculture Techniques; D016207:Cytokines / Q000276:immunology / Q000494:pharmacology; D003713:Dendritic Cells / Q000187:drug effects* / Q000276:immunology; D005434:Flow Cytometry; D056660:Hereditary Autoinflammatory Diseases / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D006801:Humans; D007113:Immunity, Innate; D016756:Immunoglobulins, Intravenous / Q000276:immunology / Q000494:pharmacology* / Q000627:therapeutic use; D056747:Immunomodulation; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology; D009000:Monocytes / Q000187:drug effects / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D015415:Biomarkers; D016207:Cytokines; D016756:Immunoglobulins, Intravenous