title: Coprismycins A and B, neuroprotective phenylpyridines from the dung beetle-associated bacterium, Streptomyces sp.
abstract: Two new phenylpyridines, named coprismycins A and B (1 and 2), and previously reported dipyridines (3-6) were isolated from a culture of Streptomyces sp. associated with the dung beetle, Copris tripartitus. The structures of the coprismycins (1 and 2) were elucidated by the analysis of 1D and 2D NMR spectra and mass, UV, and IR spectra. Coprismycins A-B (1 and 2) and dipyridines (5 and 6) displayed comparable neuroprotective effects against MPP(+) (1-methyl-4-phenylpyrimidium)-induced neurotoxicity in neuroblastoma SH-SY5Y cells.
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Seong-Hwan
authors.initials: SH
authors.lastname: Kim
authors.forename: Hyeonseok
authors.initials: H
authors.lastname: Ko
authors.forename: Hea-Son
authors.initials: HS
authors.lastname: Bang
authors.forename: Seon-Hui
authors.initials: SH
authors.lastname: Park
authors.forename: Dong-Gyu
authors.initials: DG
authors.lastname: Kim
authors.forename: Hak Cheol
authors.initials: HC
authors.lastname: Kwon
authors.forename: Sun Yeou
authors.initials: SY
authors.lastname: Kim
authors.forename: Jongheon
authors.initials: J
authors.lastname: Shin
authors.forename: Dong-Chan
authors.initials: DC
authors.lastname: Oh
mesh_terms: D015655:1-Methyl-4-phenylpyridinium / Q000633:toxicity; D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival; D001517:Coleoptera / Q000382:microbiology; D004298:Dopamine / Q000378:metabolism; D055808:Drug Discovery; D015394:Molecular Structure; D009447:Neuroblastoma; D018696:Neuroprotective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D020258:Neurotoxicity Syndromes / Q000188:drug therapy / Q000517:prevention & control; D010091:Oximes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D020734:Parkinsonian Disorders / Q000188:drug therapy / Q000517:prevention & control; D011725:Pyridines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D018696:Neuroprotective Agents; D010091:Oximes; D011725:Pyridines; C571355:coprismycin A; D015655:1-Methyl-4-phenylpyridinium; D004298:Dopamine