title: Mesenchymal niches of bone marrow in cancer.
abstract: Over the last decade, genetic and cell biology studies have indicated that tumour growth is not only determined by malignant cancer cells themselves, but also by the tumour microenvironment. Cells present in the tumour microenvironment include fibroblasts, vascular, smooth muscle, adipocytes, immune cells and mesenchymal stem cells (MSC). The nature of the relationship between MSC and tumour cells appears dual and whether MSC are pro- or anti-tumorigenic is a subject of controversial reports. This review is focused on the role of MSC and bone marrow (BM) niches in cancer.
authors.affiliation: Unidad de Biotecnología Celular, Área Biología Celular y del Desarrollo, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
authors.forename: Ander
authors.initials: A
authors.lastname: Abarrategi
authors.forename: Luis
authors.initials: L
authors.lastname: Marińas-Pardo
authors.forename: Isabel
authors.initials: I
authors.lastname: Mirones
authors.forename: Esther
authors.initials: E
authors.lastname: Rincón
authors.forename: Javier
authors.initials: J
authors.lastname: García-Castro
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001854:Bone Marrow Cells / Q000187:drug effects / Q000473:pathology* / Q000502:physiology; D019008:Drug Resistance, Neoplasm / Q000502:physiology; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects / Q000473:pathology* / Q000502:physiology; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology*; D055153:Stem Cell Niche / Q000187:drug effects / Q000502:physiology*; D059016:Tumor Microenvironment / Q000187:drug effects / Q000502:physiology
chemical_list: D000970:Antineoplastic Agents