title: [Monitoring urine metabolic profiles of rat inflammation model with capillary electrophoresis].
abstract: OBJECTIVE
  To determine the comprehensive metabolic profiling of inflammation with capillary zone electrophoresis (CZE) in rat urine.
  
  
  METHODS
  CZE-based metabolomics method was used to acquire urine metabolom data, with Computer Aided Similarity Evaluation System aligning peaks and analyzing urine profiling. Principle component analysis (PCA) was performed to compare and classify the phenotypes of the urine CZE spectra.
  
  
  RESULTS
  The PCA revealed different phenotypes of metabolites between rats with and without inflammation, which were independent from gender, individual diversity, day-night diversity and diurnal variation.
  
  
  CONCLUSIONS
  CZE-based metabolomics method could be used as a potential tool for urinary profiling for disease diagnosis and drug studies.
authors.affiliation: Department of Pharmaceutical Analysis, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Liu
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Miao
authors.forename: Hai-Lin
authors.initials: HL
authors.lastname: Yin
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Ye
authors.forename: Cong
authors.initials: C
authors.lastname: Chen
authors.forename: Zhi-Rong
authors.initials: ZR
authors.lastname: Zhang
mesh_terms: D000818:Animals; D019075:Electrophoresis, Capillary; D005260:Female; D007249:Inflammation / Q000652:urine*; D008297:Male; D055442:Metabolome; D055432:Metabolomics / Q000379:methods*; D025341:Principal Component Analysis; D051381:Rats; D017208:Rats, Wistar