title: Survival and prognostic factors in hepatitis B virus-related acute-on-chronic liver failure.
abstract: OBJECTIVE
  To investigate the survival rates and prognostic factors in patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF).
  
  
  METHODS
  Clinical data in hospitalized patients with HBV-ACLF admitted from 2006 to 2009 were retrospectively analyzed. Their general conditions and survival were analyzed by survival analysis and Cox regression analysis.
  
  
  RESULTS
  A total of 190 patients were included in this study. The overall 1-year survival rate was 57.6%. Patients not treated with antiviral drugs had a significantly higher mortality [relative risk (RR) = 0.609, P = 0.014]. The highest risk of death in patients with ACLF was associated with hepatorenal syndrome (HRS) (RR = 2.084, P =0.026), while other significant factors were electrolyte disturbances (RR = 2.062, P = 0.010), and hepatic encephalopathy (HE) (RR = 1.879, P < 0.001).
  
  
  CONCLUSIONS
  Antiviral therapy has a strong effect on the prognosis of the patients with HBV-ACLF by improving their 1-year survival rate. HRS, electrolyte disturbances, and HE also affect patient survival.
authors.affiliation: Liver Failure Treatment and Research Center, 302 Military Hospital, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Huang
authors.forename: Jin-Hua
authors.initials: JH
authors.lastname: Hu
authors.forename: Hui-Fen
authors.initials: HF
authors.lastname: Wang
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: He
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Xue-Zhang
authors.initials: XZ
authors.lastname: Duan
authors.forename: Ai-Min
authors.initials: AM
authors.lastname: Zhang
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Liu
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D058625:End Stage Liver Disease / Q000188:drug therapy / Q000209:etiology* / Q000401:mortality / Q000821:virology*; D005260:Female; D006509:Hepatitis B / Q000150:complications*; D006801:Humans; D017114:Liver Failure, Acute / Q000188:drug therapy / Q000209:etiology* / Q000401:mortality / Q000821:virology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D055815:Young Adult
chemical_list: D000998:Antiviral Agents