title: Accuracy of perfusion MRI with high spatial but low temporal resolution to assess invasive breast cancer response to neoadjuvant chemotherapy: a retrospective study.
abstract: BACKGROUND
  To illustrate that Breast-MRI performed in high spatial resolution and low temporal resolution (1 minute) allows the measurement of kinetic parameters that can assess the final pathologic response to neoadjuvant chemotherapy in breast cancer.
  
  
  METHODS
  Breast-MRI was performed in 24 women before and after treatment. Eight series of 1.11 minute-duration were acquired with a sub-millimeter spatial resolution. Transfer constant (K(trans)) and leakage space (V(e)) were calculated using measured and theoretical Arterial Input Function (AIF). Changes in kinetic parameters after treatment obtained with both AIFs were compared with final pathologic response graded in non-responder (< 50% therapeutic effect), partial-responder (> 50% therapeutic effect) and complete responder. Accuracies to identify non-responders were compared with receiver operating characteristic curves.
  
  
  RESULTS
  With measured-AIF, changes in kinetic parameters measured after treatment were in agreement with the final pathological response. Changes in V(e) and K(trans) were significantly different between non-(N = 11), partial-(N = 7), and complete (N = 6) responders, (P = 0.0092 and P = 0.0398 respectively). A decrease in V(e) of more than -72% and more than -84% for K(trans) resulted in 73% sensitivity for identifying non-responders (specificity 92% and 77% respectively). A decrease in V(e) of more than -87% helped to identify complete responders (Sensitivity 89%, Specificity 83%). With theoretical-AIF, changes in kinetic parameters had lower accuracy.
  
  
  CONCLUSIONS
  There is a good agreement between pathological findings and changes in kinetic parameters obtained with breast-MRI in high spatial and low temporal resolution when measured-AIF is used. Further studies are necessary to confirm whether MRI contrast kinetic parameters can be used earlier as a response predictor to neoadjuvant chemotherapy.
authors.affiliation: Radiologie, Hôpital Saint-Louis - Inserm U728 - Université Paris VII, 1 Avenue Claude Vellefaux, Paris, 75010, France. cedric.de-bazelaire@sls.aphp.fr
authors.forename: Cédric
authors.initials: C
authors.lastname: de Bazelaire
authors.forename: Raphael
authors.initials: R
authors.lastname: Calmon
authors.forename: Isabelle
authors.initials: I
authors.lastname: Thomassin
authors.forename: Clément
authors.initials: C
authors.lastname: Brunon
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Hamy
authors.forename: Laure
authors.initials: L
authors.lastname: Fournier
authors.forename: Daniel
authors.initials: D
authors.lastname: Balvay
authors.forename: Marc
authors.initials: M
authors.lastname: Espié
authors.forename: Nathalie
authors.initials: N
authors.lastname: Siauve
authors.forename: Olivier
authors.initials: O
authors.lastname: Clément
authors.forename: Eric
authors.initials: E
authors.lastname: de Kerviler
authors.forename: Charles-André
authors.initials: CA
authors.lastname: Cuénod
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000473:pathology*; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods* / Q000592:standards; D008833:Microcirculation; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D060787:Neoplasm Grading; D012372:ROC Curve; D012039:Regional Blood Flow; D012189:Retrospective Studies; D018709:Statistics, Nonparametric