title: Genetic heterogeneity in clinical isolates of Leishmania donovani from India.
abstract: Genetic diversity within 45 Indian Leishmania donovani isolates was analyzed using seven genetic markers. While kinetoplast DNA (kDNA) analysis revealed 15 genotypes, 8 genotypes were obtained by analysis of other markers. In contrast to earlier reports, our data suggest that significant genetic polymorphisms exist in L. donovani strains in Bihar, India. Our results confirm the presence of 2 zymodemes in India.
authors.affiliation: Infectious Disease Research Laboratory, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India 221005.
authors.forename: Pankaj
authors.initials: P
authors.lastname: Srivastava
authors.forename: Toolika
authors.initials: T
authors.lastname: Singh
authors.forename: Shyam
authors.initials: S
authors.lastname: Sundar
mesh_terms: D018105:DNA, Kinetoplast / Q000235:genetics; D016054:DNA, Protozoan / Q000235:genetics; D005819:Genetic Markers; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007194:India; D007893:Leishmania donovani / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D007898:Leishmaniasis, Visceral / Q000469:parasitology*
chemical_list: D018105:DNA, Kinetoplast; D016054:DNA, Protozoan; D005819:Genetic Markers