title: A phosphoarginine containing peptide as an artificial SH2 ligand.
abstract: We have developed a synthesis of phosphoarginine containing peptides using a bis(2,2,2-trichloroethyl) protected phosphoarginine derivative as building block. Binding studies and computer modelling demonstrate the ability of the SH2 domain from Src kinase to recognize a phosphoarginine-containing peptide in a phosphoryl group-dependent manner.
authors.affiliation: Department of Physical Biochemistry, Max Planck Institute of Molecular Physiology, Otto-Hahn Strasse 11, Dortmund, Germany.
authors.forename: Frank T
authors.initials: FT
authors.lastname: Hofmann
authors.forename: Claudia
authors.initials: C
authors.lastname: Lindemann
authors.forename: Helen
authors.initials: H
authors.lastname: Salia
authors.forename: Philipp
authors.initials: P
authors.lastname: Adamitzki
authors.forename: John
authors.initials: J
authors.lastname: Karanicolas
authors.forename: Florian P
authors.initials: FP
authors.lastname: Seebeck
mesh_terms: D001120:Arginine / Q000031:analogs & derivatives* / Q000737:chemistry; D008024:Ligands; D008958:Models, Molecular; D009943:Organophosphorus Compounds / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D019000:Phosphotyrosine / Q000737:chemistry / Q000378:metabolism; D018909:src Homology Domains; D019061:src-Family Kinases / Q000737:chemistry / Q000378:metabolism
chemical_list: D008024:Ligands; D009943:Organophosphorus Compounds; D010455:Peptides; C015441:phospho-L-arginine; D019000:Phosphotyrosine; D001120:Arginine; D019061:src-Family Kinases