title: Relapse of primary central nervous system lymphoma 13 years after high-dose methotrexate-based polychemotherapy.
abstract: We report a now 74-year-old patient who was successfully treated with a methotrexate (MTX)-ssbased polychemotherapy protocol (Bonn protocol) for primary central nervous system lymphoma (PCNSL) in 1996. When presenting with an unusually late relapse after 13 years of tumor-free survival the diagnosis was made on the basis of clinical and radiological criteria. In the context of the very limited treatment options for recurrent PCNSL, it is reassuring that the re-application of high dose-MTX-based polychemotherapy, including intraventricular treatment, again succeeded in a sustained complete response with still low neurotoxicity.
authors.affiliation: Division of Clinical Neurooncology, Department of Neurology, University of Bonn Medical School, Sigmund-Freud-Strasse 25, D-53105 Bonn, Germany.
authors.forename: J A
authors.initials: JA
authors.lastname: Steinbeck
authors.forename: M
authors.initials: M
authors.lastname: Stuplich
authors.forename: E
authors.initials: E
authors.lastname: Blasius
authors.forename: H
authors.initials: H
authors.lastname: Pels
authors.forename: M
authors.initials: M
authors.lastname: Glas
authors.forename: U
authors.initials: U
authors.lastname: Schlegel
authors.forename: U
authors.initials: U
authors.lastname: Herrlinger
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D016543:Central Nervous System Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy* / Q000473:pathology; D008727:Methotrexate / Q000627:therapeutic use*; D008875:Middle Aged; D012008:Recurrence; D012074:Remission Induction
chemical_list: D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate