title: Banking on the future: biobanking for "omics" approaches to biomarker discovery for Opisthorchis-induced cholangiocarcinoma in Thailand.
abstract: Cholangiocarcinoma (CCA)--bile duct cancer--is associated with late presentation, poses challenges for diagnosis, and has high mortality. These features t highlight the desperate need for biomarkers than can be measured early and in accessible body fluids such as plasma of people at risk for developing this lethal cancer. In this manuscript, we address previous limitations in the discovery stage of biomarker(s) for CCA and indicate how new generation of "omics" technologies could be used for biomarker discovery in Thailand. A key factor in the success of this biomarker program for CCA is the combination of cutting edge technology with strategic sample acquisition by a biorepositories.
authors.affiliation: Queensland Tropical Health Alliance, James Cook University, Cairns, QLD 4878, Australia.
authors.forename: Jason
authors.initials: J
authors.lastname: Mulvenna
authors.forename: Ponlapat
authors.initials: P
authors.lastname: Yonglitthipagon
authors.forename: Banchob
authors.initials: B
authors.lastname: Sripa
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Brindley
authors.forename: Alex
authors.initials: A
authors.lastname: Loukas
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Bethony
mesh_terms: D000818:Animals; D001650:Bile Duct Neoplasms / Q000175:diagnosis* / Q000469:parasitology / Q000473:pathology; D001653:Bile Ducts, Intrahepatic / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000097:blood / Q000145:classification; D002460:Cell Line; D018281:Cholangiocarcinoma / Q000175:diagnosis* / Q000469:parasitology / Q000473:pathology; D023281:Genomics / Q000379:methods; D006801:Humans; D008109:Liver Diseases, Parasitic / Q000175:diagnosis / Q000473:pathology; D055432:Metabolomics / Q000379:methods; D009889:Opisthorchiasis / Q000150:complications / Q000175:diagnosis* / Q000469:parasitology / Q000473:pathology; D009891:Opisthorchis / Q000502:physiology; D040901:Proteomics / Q000379:methods*; D018570:Risk Assessment; D013785:Thailand
chemical_list: D014408:Biomarkers, Tumor