title: Placental and fetal findings in intrauterine Candida lusitaniae infection following in vitro fertilization and embryo transfer.
abstract: Intrauterine infection with non- albicans Candida species is rare but can be catastrophic to the fetus. A subset of intrauterine infections with non- albicans Candida species has occurred in women who have undergone in vitro fertilization and embryo transfer (IVF-ET). We report a case of a 33-year-old healthy woman, pregnant with triplets by in vitro fertilization, who experienced preterm premature rupture of membranes of fetus A at 16 weeks' gestation and subsequently developed oligohydramnios in all 3 fetuses. Following elective pregnancy termination, microscopic examination and molecular analysis demonstrated Candida lusitaniae chorioamnionitis and pneumonia in all 3 fetuses associated with granulomatous inflammation. Our case is only the 2nd report of C. lusitaniae chorioamnionitis and should raise awareness that C. lusitaniae intrauterine infection is associated with IVF-ET. We also show here that C. lusitaniae can cause granulomatous intraplacental inflammation and intrauterine pneumonia.
authors.affiliation: Prentice Women's Hospital and Children's Memorial Hospital, Department of Pathology and Obstetrics and Gynecology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Huang
authors.forename: Elaine M
authors.initials: EM
authors.lastname: Cham
authors.forename: Carey S
authors.initials: CS
authors.lastname: Eppes
authors.forename: Susan E
authors.initials: SE
authors.lastname: Gerber
authors.forename: Kurt D
authors.initials: KD
authors.lastname: Reed
authors.forename: Linda M
authors.initials: LM
authors.lastname: Ernst
mesh_terms: D000028:Abortion, Induced; D002175:Candida; D002177:Candidiasis / Q000150:complications* / Q000382:microbiology; D002821:Chorioamnionitis / Q000382:microbiology* / Q000473:pathology; D004624:Embryo Transfer / Q000009:adverse effects*; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects*; D005333:Fetus; D006801:Humans; D008297:Male; D010920:Placenta / Q000382:microbiology / Q000473:pathology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology / Q000473:pathology*; D059286:Pregnancy, Triplet