title: Invasive fungal infection in an elderly patient with defective inflammatory macrophage function.
abstract: Macrophages are known to be involved in pathogen recognition and mediate host immune responses, but, in the clinical setting, their purported central role in opportunistic fungal infections has not been demonstrated to date. Herein, we describe a patient with invasive testicular aspergillosis in whom we found, for the first time, a defect in macrophage function.
authors.affiliation: Department of Medicine, Radboud University Nijmegen Medical Centre, and Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Nijmegen, The Netherlands.
authors.forename: L Y A
authors.initials: LY
authors.lastname: Chai
authors.forename: R
authors.initials: R
authors.lastname: Naesens
authors.forename: A L
authors.initials: AL
authors.lastname: Khoo
authors.forename: M V
authors.initials: MV
authors.lastname: Abeele
authors.forename: K
authors.initials: K
authors.lastname: van Renterghem
authors.forename: R
authors.initials: R
authors.lastname: Cartuyvels
authors.forename: M G
authors.initials: MG
authors.lastname: Netea
authors.forename: I C
authors.initials: IC
authors.lastname: Gyssens
mesh_terms: D000369:Aged, 80 and over; D001228:Aspergillosis / Q000276:immunology / Q000382:microbiology; D001232:Aspergillus fumigatus / Q000276:immunology* / Q000472:pathogenicity; D002454:Cell Differentiation; D006801:Humans; D015850:Interleukin-6 / Q000276:immunology*; D007963:Leukocytes, Mononuclear / Q000276:immunology; D016173:Macrophage Colony-Stimulating Factor / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D008297:Male; D013737:Testis / Q000382:microbiology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D016173:Macrophage Colony-Stimulating Factor