title: Recent advances in the IL-17 cytokine family.
abstract: The IL-17/IL-17 receptor family is the newest and least understood of the cytokine subclasses. Composed of ligands IL-17A-IL-17F and receptors IL-17RA-IL-17RE, these cytokines have many unique structural and functional features. Since the discovery of the 'Th17' subset in 2005, particular attention has been paid to IL-17A and IL-17F and their cognate receptors. To date, far less is known about the rest of the family. This review discusses recent advances in the field, with an emphasis on IL-17A biology.
authors.affiliation: University of Pittsburgh, Department of Medicine, Division of Rheumatology and Clinical Immunology, Pittsburgh, PA 15261, USA.
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Gaffen
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases; D002176:Candida albicans / Q000276:immunology; D002177:Candidiasis / Q000276:immunology / Q000382:microbiology; D005786:Gene Expression Regulation / Q000276:immunology*; D030342:Genetic Diseases, Inborn / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D020381:Interleukin-17 / Q000737:chemistry / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D011485:Protein Binding / Q000276:immunology; D017434:Protein Structure, Tertiary; D053722:Receptors, Interleukin-17 / Q000737:chemistry / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology*; D058504:Th17 Cells / Q000276:immunology* / Q000378:metabolism
chemical_list: C508717:IL17A protein, human; C440021:IL17F protein, human; D020381:Interleukin-17; D053722:Receptors, Interleukin-17