title: Implementation of a deidentified federated data network for population-based cohort discovery.
abstract: OBJECTIVE
  The Cross-Institutional Clinical Translational Research project explored a federated query tool and looked at how this tool can facilitate clinical trial cohort discovery by managing access to aggregate patient data located within unaffiliated academic medical centers.
  
  
  METHODS
  The project adapted software from the Informatics for Integrating Biology and the Bedside (i2b2) program to connect three Clinical Translational Research Award sites: University of Washington, Seattle, University of California, Davis, and University of California, San Francisco. The project developed an iterative spiral software development model to support the implementation and coordination of this multisite data resource.
  
  
  RESULTS
  By standardizing technical infrastructures, policies, and semantics, the project enabled federated querying of deidentified clinical datasets stored in separate institutional environments and identified barriers to engaging users for measuring utility.
  
  
  CONCLUSIONS
  The authors discuss the iterative development and evaluation phases of the project and highlight the challenges identified and the lessons learned.
  
  
  CONCLUSIONS
  The common system architecture and translational processes provide high-level (aggregate) deidentified access to a large patient population (>5 million patients), and represent a novel and extensible resource. Enhancing the network for more focused disease areas will require research-driven partnerships represented across all partner sites.
authors.affiliation: Department of Biomedical Health Informatics, University of Washington, Seattle, Washington 98109, USA. nicka@uw.edu
authors.forename: Nicholas
authors.initials: N
authors.lastname: Anderson
authors.forename: Aaron
authors.initials: A
authors.lastname: Abend
authors.forename: Aaron
authors.initials: A
authors.lastname: Mandel
authors.forename: Estella
authors.initials: E
authors.lastname: Geraghty
authors.forename: Davera
authors.initials: D
authors.lastname: Gabriel
authors.forename: Rob
authors.initials: R
authors.lastname: Wynden
authors.forename: Michael
authors.initials: M
authors.lastname: Kamerick
authors.forename: Kent
authors.initials: K
authors.lastname: Anderson
authors.forename: Julie
authors.initials: J
authors.lastname: Rainwater
authors.forename: Peter
authors.initials: P
authors.lastname: Tarczy-Hornoch
mesh_terms: D003195:Computer Communication Networks / Q000592:standards*; D003219:Confidentiality; D019992:Databases as Topic / Q000592:standards*; D006801:Humans; D016247:Information Storage and Retrieval; D039703:Logical Observation Identifiers Names and Codes; D012984:Software; D057170:Translational Research, Biomedical / Q000458:organization & administration*