title: Notch signaling and Notch signaling modifiers.
abstract: Originally discovered nearly a century ago, the Notch signaling pathway is critical for virtually all developmental programs and modulates an astounding variety of pathogenic processes. The DSL (Delta, Serrate, LAG-2 family) proteins have long been considered canonical activators of the core Notch pathway. More recently, a wide and expanding network of non-canonical extracellular factors has also been shown to modulate Notch signaling, conferring newly appreciated complexity to this evolutionarily conserved signal transduction system. Here, I review current concepts in Notch signaling, with a focus on work from the last decade elucidating novel extracellular proteins that up- or down-regulate signal potency.
authors.affiliation: Neurology Service, Veterans Administration Ann Arbor Healthcare System, Ann Arbor, MI 48105, USA. micwang@umich.edu
authors.forename: Michael M
authors.initials: MM
authors.lastname: Wang
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000502:physiology; D004705:Endocytosis / Q000502:physiology; D053263:Gene Regulatory Networks / Q000502:physiology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D008024:Ligands; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D051880:Receptors, Notch / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D008024:Ligands; D051880:Receptors, Notch