title: Development of 5-Fluorouracil derivatives as anticancer agents.
abstract: 5-Fluorouracil (5-FU) is one of the most potent antimetabolites which have been widely used in the treatment of advanced solid tumors. As an anticancer agent, because of its low efficacy and high toxicity, numerous modifications of 5-FU structure have been performed. A great number of novel 5-FU derivatives have been developed with highly efficient and much less toxic. In this paper, the recent development of novel 5-FU derivatives as potent antitumor agents is reviewed and discussed.
authors.affiliation: School of Medicine, Xi'an Jiaotong University, No. 76, Yanta West Road, 710061, Xi'an, Shaanxi Province, P.R. China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Pan
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Pengfei
authors.initials: P
authors.lastname: Li
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Hu
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Shan
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D055808:Drug Discovery; D005472:Fluorouracil / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil