title: [Role of inflammation factors in impaired glucose tolerance and sleep apnea/hypopnea syndrome in pregnant women].
abstract: OBJECTIVE
  To investigate the possible role of inflammation factors in the pathogenesis of impaired glucose tolerance (IGT) with concurrent obstructive sleep apnea/hypopnea syndrome (OSAHS) in pregnant women.
  
  
  METHODS
  Twenty-five pregnant women with IGT and concurrent OSAHS and 35 pregnant women with IGT but not OSAHS were monitored for all night polysomnography (PSG), and the apnea hypopnea index (AHI) and the lowest pulse oxygen saturation (LSpO2) were recorded. The body mass index, glycated serum protein (GSP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were measured in these women.
  
  
  RESULTS
  IL-6 and TNF-α levels increased significantly in women with IGT and OSAHS as compared with those in women without OSAHS. AHI showed significant positive correlations to GSP, IL-6 and TNF-α, whereas LSpO2 was inversely correlated to GSP, IL-6 and TNF-α. IL-6 and TNF-α were significantly correlated to GSP, with correlation coefficients of 0.510 and 0.476, respectively.
  
  
  CONCLUSIONS
  The inflammatory factors may play important roles in IGT complicated by OSAHS in pregnant women, and as a potential risk factor, OSAHS may contribute to the occurrence of progression of IGT.
authors.affiliation: Sleep Center, Nanfang Hospital, Southern Medical University, Guangzhou, China. zhiminshi@163.com
authors.forename: Zhi-min
authors.initials: ZM
authors.lastname: Shi
authors.forename: Tao-ping
authors.initials: TP
authors.lastname: Li
authors.forename: Le-wu
authors.initials: LW
authors.lastname: Xian
authors.forename: Zheng-gong
authors.initials: ZG
authors.lastname: Li
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D010092:Oximetry; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000502:physiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*; D012891:Sleep Apnea Syndromes / Q000097:blood* / Q000503:physiopathology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D001786:Blood Glucose; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D010100:Oxygen