title: [Effect of fullerene C60 on functional activity of phagocytic cells].
abstract: The effect of aqueous dispersion of fullerene C60 (FC60) on the functional activity of cells involved in the phagocytosis reactions was studied. FC60 (0.01 microM/l and 0.1 microM/l) produced mainly negative effects on the activity ofnonspecific immunity cells by inhibiting the myeloperoxidase enzymatic activity, decreased the level of induced chemiluminescence, and suppressed the expression of molecules CD54 involved in the adhesion. The only exception was a slight stimulating effect on the NBT test. The results indicate the FC60 influences various stages and mechanisms of phagocytosis.
authors.forename: L É
authors.initials: LÉ
authors.lastname: Vesnina
authors.forename: T V
authors.initials: TV
authors.lastname: Mamontova
authors.forename: M V
authors.initials: MV
authors.lastname: Mikitiuk
authors.forename: N L
authors.initials: NL
authors.lastname: Kutsenko
authors.forename: L A
authors.initials: LA
authors.lastname: Kutsenko
authors.forename: N A
authors.initials: NA
authors.lastname: Bobrova
authors.forename: L V
authors.initials: LV
authors.lastname: Berkalo
authors.forename: I P
authors.initials: IP
authors.lastname: Kaĭdashev
mesh_terms: D000328:Adult; D002448:Cell Adhesion / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D037741:Fullerenes / Q000009:adverse effects*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood / Q000187:drug effects; D049449:Luminescence; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000187:drug effects; D009504:Neutrophils / Q000187:drug effects*; D009195:Peroxidase / Q000037:antagonists & inhibitors*; D010587:Phagocytosis / Q000187:drug effects*
chemical_list: D037741:Fullerenes; D018799:Intercellular Adhesion Molecule-1; D009195:Peroxidase; C069837:fullerene C60