title: Catalytic enantioselective oxaziridination.
abstract: The first catalytic enantioselective synthesis of oxaziridines is presented. The oxidation of aryl and alkyl aldimines with m-CPBA under organocatalytic conditions using cinchona alkaloid-derived catalysts furnished optically active oxaziridines in good yields and high enantioselectivities (up to 94% ee). Mechanistic investigations indicate a stepwise enantioselective oxidation process.
authors.affiliation: Center for Catalysis, Department of Chemistry, Aarhus University, Aarhus C, Denmark.
authors.forename: Lennart
authors.initials: L
authors.lastname: Lykke
authors.forename: Carles
authors.initials: C
authors.lastname: Rodríguez-Escrich
authors.forename: Karl Anker
authors.initials: KA
authors.lastname: Jørgensen
mesh_terms: D001388:Aziridines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D001388:Aziridines