title: Protective effect of neurotrophic agent T-817MA against inner ear barotrauma in the guinea pig.
abstract: T-817MA (1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}azetidin-3-ol maleate), a neurotrophic compound newly synthesized for the treatment of Alzheimer's disease, has been found to reduce oxidative stress and exert neuroprotective effects. By assessing the auditory functioning and observing the cochlear sensory epithelia, we investigated whether T-817MA protects the cochlea from inner ear barotrauma in guinea pigs treated with rapidly intense pressure change. Sustained oral administration of T-817MA significantly reduced the extent of auditory threshold shifts and outer hair cell loss, indicating that T-817MA attenuates the intense pressure-induced cochlear damage that accompanies inner ear barotrauma via antioxidative activity.
authors.affiliation: Department of Otolaryngology, National Defense Medical College, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Maekawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Matsunobu
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Satoh
authors.forename: Takaomi
authors.initials: T
authors.lastname: Kurioka
authors.forename: Asako
authors.initials: A
authors.lastname: Nakamura
authors.forename: Noboru
authors.initials: N
authors.lastname: Iwakami
authors.forename: Akihiro
authors.initials: A
authors.lastname: Shiotani
mesh_terms: D000818:Animals; D001469:Barotrauma / Q000517:prevention & control*; D007758:Ear, Inner / Q000473:pathology*; D006168:Guinea Pigs; D018696:Neuroprotective Agents / Q000627:therapeutic use*
chemical_list: D018696:Neuroprotective Agents