title: Vitamin K supplement along with vitamin D and calcium reduced serum concentration of undercarboxylated osteocalcin while increasing bone mineral density in Korean postmenopausal women over sixty-years-old.
abstract: There are inconsistent findings on the effects of vitamin K on bone mineral density (BMD) and undercarboxylated osteocalcin (UcOC). The present intervention study evaluated the effect in subjects over 60-yr-old. The vitamin K group (vitamin K + vitamin D + calcium supplement; 15 mg of vitamin K2 [menatetrenone] three times daily, 400 IU of vitamin D once a day, and 315 mg of calcium twice daily) and the control group (vitamin D + calcium supplement) were randomly assigned. During the six months of treatment, seventy eight women participated (38 in the vitamin K group and 40 in the control group) and 45 women completed the study. The baseline characteristics of study participants did not differ between the vitamin K and the control groups. In a per protocol analysis after 6 months, L3 bone mineral density has increased statistically significantly in the vitamin K group compared to the control group (0.01 ± 0.03 g/cm(2) vs -0.008 ± 0.04 g/cm(2), P = 0.049). UcOC concentration was also significantly decreased in the vitamin K group (-1.6 ± 1.6 ng/dL vs -0.4 ± 1.1 ng/dL, P = 0.008). In conclusion, addition of vitamin K to vitamin D and calcium supplements in the postmenopausal Korean women increase the L3 BMD and reduce the UcOC concentration.
authors.affiliation: Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Sang Hyeon
authors.initials: SH
authors.lastname: Je
authors.forename: Nam-Seok
authors.initials: NS
authors.lastname: Joo
authors.forename: Beom-hee
authors.initials: BH
authors.lastname: Choi
authors.forename: Kwang-Min
authors.initials: KM
authors.lastname: Kim
authors.forename: Bom-Taeck
authors.initials: BT
authors.lastname: Kim
authors.forename: Sat-Byul
authors.initials: SB
authors.lastname: Park
authors.forename: Doo-Yeoun
authors.initials: DY
authors.lastname: Cho
authors.forename: Kyu-Nam
authors.initials: KN
authors.lastname: Kim
authors.forename: Duck-Joo
authors.initials: DJ
authors.lastname: Lee
mesh_terms: D000368:Aged; D015519:Bone Density / Q000187:drug effects*; D002118:Calcium / Q000008:administration & dosage*; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood*; D017698:Postmenopause; D056910:Republic of Korea; D014807:Vitamin D / Q000008:administration & dosage*; D014812:Vitamin K / Q000008:administration & dosage*
chemical_list: D015675:Osteocalcin; D014812:Vitamin K; D014807:Vitamin D; D002118:Calcium