title: Tafluprost: a novel prostaglandin analog for treatment of glaucoma.
abstract: OBJECTIVE
  The objective of this review is to evaluate the safety and efficacy of tafluprost, a fluoroprostaglandin receptor analog, for reduction of intraocular pressure in open angle glaucoma and ocular hypertension.
  
  
  METHODS
  A search of published literature was performed on the PubMed database using the search term "tafluprost." The literature search identified 48 publications, including clinical and preclinical studies, from 2003 to 2011. From these ressults, articles available in the English language and in full text were selected and systematically reviewed by the authors.
  
  
  RESULTS
  Recent studies have shown that tafluprost is an effective IOP-lowering medication. Evidence based medicine also reveals that tafluprost is safe and well-tolerated. Preservative-free tafluprost is as potent as the preserved formulation, but with fewer and milder ocular surface side effects.
  
  
  CONCLUSIONS
  Since its introduction in 2008, initial studies have demonstrated that preserved and preservative-free tafluprost formulations have proven efficacy and safety in the treatment of glaucoma and ocular hypertension. Larger studies with longer follow-up are needed to assess long-term safety, efficacy, and tolerability compared with other prostaglandin analogs used for treating glaucoma.
authors.affiliation: Ophthalmology Department, University of Colorado School of Medicine, 1675 Aurora Court, Aurora, CO 80045, USA.
authors.forename: Mina B
authors.initials: MB
authors.lastname: Pantcheva
authors.forename: Leonard K
authors.initials: LK
authors.lastname: Seibold
authors.forename: Nida S
authors.initials: NS
authors.lastname: Awadallah
authors.forename: Malik Y
authors.initials: MY
authors.lastname: Kahook
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D009798:Ocular Hypertension / Q000188:drug therapy*; D011460:Prostaglandins F / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D011460:Prostaglandins F; C485333:tafluprost