title: Evaluation of routinely performed hematological and biochemical parameters for the prognosis of acute ischemic stroke patients.
abstract: We have investigated serial changes in routine hematological and biochemical analysis in the follow-up samples collected from acute ischemic stroke (AIS) patients (n = 17) at admission (0 h) and 24, 48, 72 and 144 h after admission, respectively, to determine their prognostic significance. Blood samples from age and sex matched healthy control subjects (n = 12) were also collected. We observed significant changes in erythrocyte sedimentation rate (ESR), white blood cell count (WBC), polymorph, lymphocyte, and total protein levels in discharged and expired AIS patients. These changes were more in expired AIS patient throughout the follow-up. Similarly low hemoglobin (Hb) and globulin were observed only in expired AIS patient. Thus ESR, WBC, polymorph, lymphocyte, and total protein may be used as a predictor for severity of AIS. Similarly low Hb and globulin in AIS patient may be used as a predictive biomarker for short-term mortality after AIS.
authors.affiliation: Biochemistry Research Laboratory, Central India Institute of Medical Sciences, Nagpur 440010, India.
authors.forename: Amit R
authors.initials: AR
authors.lastname: Nayak
authors.forename: Rajpal S
authors.initials: RS
authors.lastname: Kashyap
authors.forename: Dinesh
authors.initials: D
authors.lastname: Kabra
authors.forename: Prashant
authors.initials: P
authors.lastname: Deoras
authors.forename: Hemant J
authors.initials: HJ
authors.lastname: Purohit
authors.forename: Girdhar M
authors.initials: GM
authors.lastname: Taori
authors.forename: Hatim F
authors.initials: HF
authors.lastname: Daginawala
mesh_terms: D000328:Adult; D000368:Aged; D001799:Blood Sedimentation; D002545:Brain Ischemia / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D020521:Stroke / Q000175:diagnosis*