title: Clinical importance of matrix metalloproteinases.
abstract: This review gives a brief summary on clinical applications of MMPs and their determination. Primarily, the activity of MMPs in cancer formation, development and metastasis is discussed. Further, survey on methods including fluorimetric methods, zymographies, Western-blotting, immunocapture assay, enzyme-linked immunosorbent assay, immunocytochemistry and immunohistochemistry, phage display, multiple-enzyme/multiple-reagent system, activity profiling, chronopotentiometric stripping analysis and imaging methods for detection and determination of MMPs follows (Fig. 3, Ref. 100).
authors.affiliation: Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Brno, Czech Republic.
authors.forename: S
authors.initials: S
authors.lastname: Krizkova
authors.forename: O
authors.initials: O
authors.lastname: Zitka
authors.forename: M
authors.initials: M
authors.lastname: Masarik
authors.forename: V
authors.initials: V
authors.lastname: Adam
authors.forename: M
authors.initials: M
authors.lastname: Stiborova
authors.forename: T
authors.initials: T
authors.lastname: Eckschlager
authors.forename: J
authors.initials: J
authors.lastname: Hubalek
authors.forename: R
authors.initials: R
authors.lastname: Kizek
mesh_terms: D015415:Biomarkers / Q000032:analysis; D006801:Humans; D020782:Matrix Metalloproteinases / Q000032:analysis / Q000737:chemistry / Q000502:physiology*; D009369:Neoplasms / Q000175:diagnosis / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D020782:Matrix Metalloproteinases