title: A facile synthesis, in vitro and in vivo MR studies of d-glucuronic acid-coated ultrasmall Ln₂O₃ (Ln = Eu, Gd, Dy, Ho, and Er) nanoparticles as a new potential MRI contrast agent.
abstract: A facile one-pot synthesis of d-glucuronic acid-coated ultrasmall Ln(2)O(3) (Ln = Eu, Gd, Dy, Ho, and Er) nanoparticles is presented. Their water proton relaxivities were studied to address their possibility as a new potential MRI contrast agent. We focused on the d-glucuronic acid-coated ultrasmall Dy(2)O(3) nanoparticle because it showed the highest r(2) relaxivity among studied nanoparticles. Its performance as a T(2) MRI contrast agent was for the first time proved in vivo through its 3 T T(2) MR images of a mouse, showing that it can be further exploited for the rational design of a new T(2) MRI contrast agent at high MR fields.
authors.affiliation: Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 702-701, South Korea.
authors.forename: Krishna
authors.initials: K
authors.lastname: Kattel
authors.forename: Ja Young
authors.initials: JY
authors.lastname: Park
authors.forename: Wenlong
authors.initials: W
authors.lastname: Xu
authors.forename: Han Gyeol
authors.initials: HG
authors.lastname: Kim
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: Lee
authors.forename: Badrul Alam
authors.initials: BA
authors.lastname: Bony
authors.forename: Woo Choul
authors.initials: WC
authors.lastname: Heo
authors.forename: Jae Jun
authors.initials: JJ
authors.lastname: Lee
authors.forename: Seonguk
authors.initials: S
authors.lastname: Jin
authors.forename: Jong Su
authors.initials: JS
authors.lastname: Baeck
authors.forename: Yongmin
authors.initials: Y
authors.lastname: Chang
authors.forename: Tae Jeong
authors.initials: TJ
authors.lastname: Kim
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Bae
authors.forename: Kwon Seok
authors.initials: KS
authors.lastname: Chae
authors.forename: Gang Ho
authors.initials: GH
authors.lastname: Lee
mesh_terms: D000818:Animals; D002460:Cell Line; D003287:Contrast Media / Q000138:chemical synthesis* / Q000633:toxicity; D004419:Dysprosium / Q000737:chemistry; D004871:Erbium / Q000737:chemistry; D005063:Europium / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry; D020723:Glucuronic Acid / Q000737:chemistry*; D006695:Holmium / Q000737:chemistry; D007668:Kidney / Q000000981:diagnostic imaging; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D008099:Liver / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging; D008297:Male; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D008813:Mice, Inbred ICR; D011877:Radionuclide Imaging
chemical_list: D003287:Contrast Media; D028581:Lanthanoid Series Elements; D004419:Dysprosium; D005063:Europium; D004871:Erbium; D020723:Glucuronic Acid; D005682:Gadolinium; D006695:Holmium