title: Development of acute megakaryoblastic leukemia with isochromosome (12p) after a primary mediastinal germ cell tumor in Korea.
abstract: The association of hematological malignancies with a mediastinal germ cell tumor (GCT) is very rare. We report one case of a young adult male with primary mediastinal GCT who subsequently developed acute megakaryoblastic leukemia involving isochromosome (12p). A 25-yr-old man had been diagnosed with a mediastinal GCT and underwent surgical resection and adjuvant chemotherapy. At 1 week after the last cycle of chemotherapy, his peripheral blood showed leukocytosis with blasts. A bone marrow study confirmed the acute megakaryoblastic leukemia. A cytogenetic study revealed a complex karyotype with i(12p). Although additional chemotherapy was administered, the patient could not attain remission and died of septic shock. This case was definitely distinct from therapy-related secondary leukemia in terms of clinical, morphologic, and cytogenetic features. To our knowledge, this is the first case report of a patient with mediastinal GCT subsequently developing acute megakaryoblastic leukemia involving i(12p) in Korea.
authors.affiliation: Department of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Nae
authors.initials: N
authors.lastname: Yu
authors.forename: Hye Ryoun
authors.initials: HR
authors.lastname: Kim
authors.forename: Young-Joo
authors.initials: YJ
authors.lastname: Cha
authors.forename: Eun Kyung
authors.initials: EK
authors.lastname: Park
authors.forename: Jeong Wook
authors.initials: JW
authors.lastname: Kim
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage; D001853:Bone Marrow / Q000473:pathology; D002881:Chromosomes, Human, Pair 12; D002945:Cisplatin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D018404:Isochromosomes; D007621:Karyotyping; D007947:Leukemia, Megakaryoblastic, Acute / Q000188:drug therapy / Q000209:etiology / Q000235:genetics*; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D009373:Neoplasms, Germ Cell and Embryonal / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D016609:Neoplasms, Second Primary / Q000188:drug therapy / Q000209:etiology / Q000235:genetics*; D056910:Republic of Korea; D012772:Shock, Septic / Q000473:pathology
chemical_list: D001761:Bleomycin; D005047:Etoposide; D002945:Cisplatin