title: Biokinetics and dosimetry of commonly used radiopharmaceuticals in diagnostic nuclear medicine - a review.
abstract: OBJECTIVE
  The impact on patients' health of radiopharmaceuticals in nuclear medicine diagnostics has not until now been evaluated systematically in a European context. Therefore, as part of the EU-funded Project PEDDOSE.NET (                               www.peddose.net                                                           ), we review and summarize the current knowledge on biokinetics and dosimetry of commonly used diagnostic radiopharmaceuticals.
  
  
  METHODS
  A detailed literature search on published biokinetic and dosimetric data was performed mostly via PubMed (                               www.ncbi.nlm.nih.gov/pubmed                                                           ). In principle the criteria for inclusion of data followed the EANM Dosimetry Committee guidance document on good clinical reporting.
  
  
  RESULTS
  Data on dosimetry and biokinetics can be difficult to find, are scattered in various journals and, especially in paediatric nuclear medicine, are very scarce. The data collection and calculation methods vary with respect to the time-points, bladder voiding, dose assessment after the last data point and the way the effective dose was calculated. In many studies the number of subjects included for obtaining biokinetic and dosimetry data was fewer than ten, and some of the biokinetic data were acquired more than 20 years ago.
  
  
  CONCLUSIONS
  It would be of interest to generate new data on biokinetics and dosimetry in diagnostic nuclear medicine using state-of-the-art equipment and more uniform dosimetry protocols. For easier public access to dosimetry data for diagnostic radiopharmaceuticals, a database containing these data should be created and maintained.
authors.affiliation: Department of Nuclear Medicine, University of Würzburg, Oberdürrbacher Str. 6, 97080 Würzburg, Germany. eberlein_u@klinik.uni-wuerzburg.de
authors.forename: Uta
authors.initials: U
authors.lastname: Eberlein
authors.forename: Jörn Hendrik
authors.initials: JH
authors.lastname: Bröer
authors.forename: Charlot
authors.initials: C
authors.lastname: Vandevoorde
authors.forename: Paula
authors.initials: P
authors.lastname: Santos
authors.forename: Manuel
authors.initials: M
authors.lastname: Bardiès
authors.forename: Klaus
authors.initials: K
authors.lastname: Bacher
authors.forename: Dietmar
authors.initials: D
authors.lastname: Nosske
authors.forename: Michael
authors.initials: M
authors.lastname: Lassmann
mesh_terms: D001822:Body Burden; D003198:Computer Simulation; D006801:Humans; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D019275:Radiopharmaceuticals / Q000032:analysis / Q000493:pharmacokinetics*
chemical_list: D019275:Radiopharmaceuticals