title: Late polypropylene mesh susceptibility to infection during intra-abdominal sepsis.
abstract: OBJECTIVE
  To evaluate the susceptibility of high-density polypropylene mesh to contamination, 1 year after experimental hernia repair.
  
  
  METHODS
  Wistar rats were randomized into two groups: one experimental group (n = 20) and another control group (n = 10). Mesh hernia repair was performed with intra-abdominal (group I, n = 10) or subcutaneous (group II, n = 10) implantation of grafts. The three groups were exposed to an intra-abdominal E. coli administration after 1 year of operation. After 24 hr, the meshes and peritoneum were sampled from the experimental and control groups, respectively, in order to assess bacterial inoculation. Immunoreaction to E. coli inoculation was also evaluated after 24 hr by measuring serum interleukin-6 (IL-6) and C-reactive protein (CRP) levels.
  
  
  RESULTS
  Bacteriological analysis revealed increased contamination in groups I and II when compared with the control group (p = .001 and .007, respectively). IL-6 levels were increased in both groups I and II compared with the control group, 24 hr after E. coli injection (p = .034 and .022, respectively), while there was no statistically significant difference between groups concerning the concentration of CRP.
  
  
  CONCLUSIONS
  Polypropylene mesh is vulnerable to bacterial inoculation during intra-abdominal sepsis 1 year after mesh placement.
authors.affiliation: Second Department of Surgery, Experimental Surgery Unit, School of Medicine, Aretaieion University Hospital, University of Athens, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Vassiliou
authors.forename: Vassiliou
authors.initials: V
authors.lastname: Ioannis
authors.forename: Aliki
authors.initials: A
authors.lastname: Tympa
authors.forename: Tympa
authors.initials: T
authors.lastname: Aliki
authors.forename: Theodosios
authors.initials: T
authors.lastname: Theodosopoulos
authors.forename: Theodosopoulos
authors.initials: T
authors.lastname: Theodosios
authors.forename: Constantinos
authors.initials: C
authors.lastname: Nastos
authors.forename: Nastos
authors.initials: N
authors.lastname: Constantinos
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Arkadopoulos
authors.forename: Arkadopoulos
authors.initials: A
authors.lastname: Nikolaos
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Dafnios
authors.forename: Dafnios
authors.initials: D
authors.lastname: Nikolaos
authors.forename: Georgios
authors.initials: G
authors.lastname: Fragulidis
authors.forename: Fragulidis
authors.initials: F
authors.lastname: Georgios
authors.forename: Evangelia
authors.initials: E
authors.lastname: Kouskouni
authors.forename: Kouskouni
authors.initials: K
authors.lastname: Evangelia
authors.forename: Vassilios
authors.initials: V
authors.lastname: Smyrniotis
authors.forename: Smyrniotis
authors.initials: S
authors.lastname: Vassilios
mesh_terms: D000818:Animals; D002097:C-Reactive Protein / Q000032:analysis; D004927:Escherichia coli Infections / Q000209:etiology*; D019453:Escherichia coli O157; D046449:Hernia, Abdominal / Q000601:surgery; D059685:Herniorrhaphy / Q000009:adverse effects; D015850:Interleukin-6 / Q000032:analysis; D008297:Male; D011126:Polypropylenes; D011183:Postoperative Complications / Q000382:microbiology; D019736:Prostheses and Implants / Q000382:microbiology*; D051381:Rats; D017208:Rats, Wistar; D018805:Sepsis / Q000150:complications*; D013526:Surgical Mesh / Q000382:microbiology*
chemical_list: D015850:Interleukin-6; D011126:Polypropylenes; D002097:C-Reactive Protein