title: Dosimetric feasibility study for an extracorporeal BNCT application on liver metastases at the TRIGA Mainz.
abstract: This study investigates the dosimetric feasibility of Boron Neutron Capture Therapy (BNCT) of explanted livers in the thermal column of the research reactor in Mainz. The Monte Carlo code MCNP5 is used to calculate the biologically weighted dose for different ratios of the (10)B-concentration in tumour to normal liver tissue. The simulation results show that dosimetric goals are only partially met. To guarantee effective BNCT treatment the organ has to be better shielded from all gamma radiation.
authors.affiliation: Health & Environment Department-Molecular Medicine, AIT Austrian Institute of Technology GmbH, Muthgasse 11, A-1190 Vienna, Austria. matthias.blaickner@ait.ac.at
authors.forename: M
authors.initials: M
authors.lastname: Blaickner
authors.forename: J V
authors.initials: JV
authors.lastname: Kratz
authors.forename: S
authors.initials: S
authors.lastname: Minouchehr
authors.forename: G
authors.initials: G
authors.lastname: Otto
authors.forename: H
authors.initials: H
authors.lastname: Schmidberger
authors.forename: C
authors.initials: C
authors.lastname: Schütz
authors.forename: L
authors.initials: L
authors.lastname: Vogtländer
authors.forename: B
authors.initials: B
authors.lastname: Wortmann
authors.forename: G
authors.initials: G
authors.lastname: Hampel
mesh_terms: D016754:Boron Neutron Capture Therapy / Q000379:methods*; D003198:Computer Simulation; D006801:Humans; D008113:Liver Neoplasms / Q000503:physiopathology / Q000532:radiotherapy* / Q000556:secondary*; D008954:Models, Biological; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage