title: High fetal plasma adenosine concentration: a role for the fetus in preeclampsia?
abstract: OBJECTIVE
  Clinical observations suggest a role for the fetus in the maternal manifestations of preeclampsia, but the possible signaling mechanisms remain unclear. This study compares the fetal plasma concentrations of adenosine from normal pregnancies with those from preeclampsia.
  
  
  METHODS
  This secondary data analysis included normal pregnancies (n = 27) and patients with preeclampsia (n = 39). Patients with preeclampsia were subclassified into patients with (n = 25) and without (n = 14) abnormal uterine artery Doppler velocimetry (UADV).
  
  
  RESULTS
  Fetal plasma concentrations of adenosine were significantly higher in patients with preeclampsia (1.35 ± 0.09 μmol/L) than in normal pregnancies (0.52 ± 0.06 μmol/L; P < .0001). Fetal plasma concentrations of adenosine in patients with preeclampsia with abnormal UADV (1.78 ± 0.15 μmol/L), but not with normal UADV (0.58 ± 0.14 μmol/L), were significantly higher than in normal pregnancies (P < .0001).
  
  
  CONCLUSIONS
  Patients with preeclampsia with sonographic evidence of chronic uteroplacental ischemia have high fetal plasma concentrations of adenosine.
authors.affiliation: Department of Obstetrics and Gynecology, William Beaumont Hospital, Royal Oak Michigan and Oakland University, Rochester, MI, USA. jimmy.espinoza@beaumont
authors.forename: Jimmy
authors.initials: J
authors.lastname: Espinoza
authors.forename: Andres F
authors.initials: AF
authors.lastname: Espinoza
authors.forename: Gordon G
authors.initials: GG
authors.lastname: Power
mesh_terms: D000241:Adenosine / Q000097:blood*; D000328:Adult; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood / Q000209:etiology*; D011247:Pregnancy; D055988:Uterine Artery
chemical_list: D000241:Adenosine