title: Synthesis of deuterium labeled ketamine metabolite dehydronorketamine-d₄.
abstract: A convenient synthesis of ketamine metabolite dehydronorketamine-d(4), starting from commercially available deuterium labeled bromochlorobenzene, was achieved. Key steps include Grignard reaction, regioselective hydroxybromination, Staudinger reduction, and dehydrohalogenation.
authors.affiliation: Department of Chemistry, National Dong Hwa University, No. 1, Sec. 2, Da Hsueh Rd. Soufeng, Hualien 97401, Taiwan.
authors.forename: Rohidas S
authors.initials: RS
authors.lastname: Sulake
authors.forename: Chinpiao
authors.initials: C
authors.lastname: Chen
authors.forename: Huei-Ru
authors.initials: HR
authors.lastname: Lin
authors.forename: Ahai-Chang
authors.initials: AC
authors.lastname: Lua
mesh_terms: D002722:Chlorobenzenes / Q000737:chemistry* / Q000378:metabolism; D003903:Deuterium / Q000378:metabolism; D015195:Drug Design; D055808:Drug Discovery; D054879:Halogenation; D007649:Ketamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*
chemical_list: D002722:Chlorobenzenes; D007649:Ketamine; D003903:Deuterium; C031294:chlorobenzene; C033419:norketamine