title: The plasma concentration of the B cell activating factor is increased in children with acute malaria.
abstract: Malaria-specific antibody responses in children often appear to be short-lived but the mechanisms underlying this phenomenon are not well understood. In this study, we investigated the relationship between the B-cell activating factor (BAFF) and its receptors expressed on B cells with antibody responses during and after acute malaria in children. Our results demonstrate that BAFF plasma levels increased during acute malarial disease and reflected disease severity. The expression profiles for BAFF receptors on B cells agreed with rapid activation and differentiation of a proportion of B cells to plasma cells. However, BAFF receptor (BAFF-R) expression was reduced on all peripheral blood B cells during acute infection, but those children with the highest level of BAFF-R expression on B cells maintained schizont-specific immunoglobin G (IgG) over a period of 4 months, indicating that dysregulation of BAFF-R expression on B cells may contribute to short-lived antibody responses to malarial antigens in children. In summary, this study suggests a potential role for BAFF during malaria disease, both as a marker for disease severity and in shaping the differentiation pattern of antigen-specific B cells.
authors.affiliation: KEMRI/Wellcome Trust Collaborative Research Program, Centre for Geographical Medicine Research, Kilifi, Kenya.
authors.forename: Eunice
authors.initials: E
authors.lastname: Nduati
authors.forename: Agnes
authors.initials: A
authors.lastname: Gwela
authors.forename: Henry
authors.initials: H
authors.lastname: Karanja
authors.forename: Cleopatra
authors.initials: C
authors.lastname: Mugyenyi
authors.forename: Jean
authors.initials: J
authors.lastname: Langhorne
authors.forename: Kevin
authors.initials: K
authors.lastname: Marsh
authors.forename: Britta C
authors.initials: BC
authors.lastname: Urban
mesh_terms: D000913:Antibodies, Protozoan / Q000276:immunology; D053264:B-Cell Activating Factor / Q000097:blood*; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007223:Infant; D008288:Malaria / Q000175:diagnosis* / Q000473:pathology*; D010949:Plasma / Q000737:chemistry*; D012720:Severity of Illness Index
chemical_list: D000913:Antibodies, Protozoan; D053264:B-Cell Activating Factor; D007074:Immunoglobulin G