title: Anti-neuronal and stress-induced-phosphoprotein 1 antibodies in neuro-Behçet's disease.
abstract: No disease-specific neuronal antibodies have so far been defined in neuro-Behçet's disease (NBD). Immunohistochemistry and immunocytochemistry studies showed antibodies to hippocampal and cerebellar molecular layers and the surface antigens of cultured hippocampal neurons in sera and/or cerebrospinal fluids (CSF) of 13 of 20 NBD and 6 of 20 BD patients but not in multiple sclerosis or headache controls. Screening with a protein macroarray led to identification of stress-induced-phosphoprotein-1 (STIP-1) as an antigenic target. High-titer STIP-1-antibodies were detected in 6 NBD patients' sera but not in controls. These results suggest that neuronal antibodies could be useful as diagnostic biomarkers in NBD.
authors.affiliation: Department of Genetics, Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Burçak
authors.initials: B
authors.lastname: Vural
authors.forename: Elif
authors.initials: E
authors.lastname: Uğurel
authors.forename: Erdem
authors.initials: E
authors.lastname: Tüzün
authors.forename: Murat
authors.initials: M
authors.lastname: Kürtüncü
authors.forename: Luigi
authors.initials: L
authors.lastname: Zuliani
authors.forename: Filiz
authors.initials: F
authors.lastname: Cavuş
authors.forename: Sema
authors.initials: S
authors.lastname: Içöz
authors.forename: Ece
authors.initials: E
authors.lastname: Erdağ
authors.forename: Ahmet
authors.initials: A
authors.lastname: Gül
authors.forename: Ali O
authors.initials: AO
authors.lastname: Güre
authors.forename: Angela
authors.initials: A
authors.lastname: Vincent
authors.forename: Uğur
authors.initials: U
authors.lastname: Ozbek
authors.forename: Mefkure
authors.initials: M
authors.lastname: Eraksoy
authors.forename: Gülşen
authors.initials: G
authors.lastname: Akman-Demir
mesh_terms: D000328:Adult; D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis*; D001528:Behcet Syndrome / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006360:Heat-Shock Proteins / Q000097:blood / Q000276:immunology*; D006624:Hippocampus / Q000098:blood supply / Q000276:immunology / Q000473:pathology; D006801:Humans; D008297:Male; D050606:Mannose-Binding Protein-Associated Serine Proteases / Q000502:physiology; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D009410:Nerve Degeneration / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D009474:Neurons / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D009928:Organ Specificity / Q000276:immunology; D051381:Rats
chemical_list: D001323:Autoantibodies; D006360:Heat-Shock Proteins; C079373:STIP1 protein, human; C105296:MASP2 protein, human; D050606:Mannose-Binding Protein-Associated Serine Proteases