title: P50 variations in Behcet`s patients without neurologic findings.
abstract: OBJECTIVE
  In the present study, subclinical lesion involvement was investigated using the P50 component in Behcet`s patients without neurological manifestation.
  
  
  METHODS
  We performed this clinical research in Erciyes University, Faculty of Medicine between December 2000 and November 2001. The studies were carried out on 18 Behcet`s patients without neurologic findings and 18 volunteers for control. Standard Ag/AgCl electrodes in plastic cups were used for monopolar EEG derivations. They were attached with electrode paste and tape at the Cz (vertex) according to the 10-20 system. The auditory stimuli were delivered in pairs. The P50 waves, which may be taken from approximately 50 msec from the stimuli, were collected by computer system. Amplitudes and latencies of the P50 components were measured in the same system.
  
  
  RESULTS
  This study showed that the suppression of P50 responses performed by the test stimuli, was significantly more decreased in Behcet`s patients than the control subjects.
  
  
  CONCLUSIONS
  The decrease of the suppression of the auditory P50 response to repeated stimuli reflects a deficit in the central nervous system`s ability, such as attention, cognition, and sensory input in Behcet`s patients and can be used as a neurophysiological marker in subclinical lesions in these patients.
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Erciyes, Kayseri, Turkey.
authors.forename: Meral
authors.initials: M
authors.lastname: Ascioglu
authors.forename: Mustafa
authors.initials: M
authors.lastname: Arslan
authors.forename: Cem
authors.initials: C
authors.lastname: Suer
authors.forename: Ozcan
authors.initials: O
authors.lastname: Ascioglu
authors.forename: Cigdem
authors.initials: C
authors.lastname: Ozesmi
authors.forename: Murat
authors.initials: M
authors.lastname: Borlu
authors.forename: Abdulhakim
authors.initials: A
authors.lastname: Coskun
authors.forename: Ali S
authors.initials: AS
authors.lastname: Gonul
authors.forename: Emel
authors.initials: E
authors.lastname: Koseoglu