title: [Comparisons of epidemiological and clinical characteristics in children with hand-foot-mouth disease caused by Enterovirus 71 and Coxackievirus A16].
abstract: OBJECTIVE
  To compare the differences of epidemiological and clinical characteristics in children with hand-foot-mouth disease (HFMD) caused by Coxsackievirus A16 (CA16) and Enterovirus 71 (EV71).
  
  
  METHODS
  The samples of vesicle fluid and throat swabs of 108 children with HFMD were collected and detected for enterovirus by RT-PCR. The clinical data of children with EV71 and CA16 infection were retrospectively reviewed and compared.
  
  
  RESULTS
  The total positive rate of enterovirus was 97.2% (105/108). Of the 105 cases, 56 cases were positive for EV71 (51.9%), 39 cases were positive for CA16 (36.1%), 2 cases were positive for other enterovirus (1.9%), and 8 cases were co-infected by EV71 and CA16 (7.4%). There were no significant differences in age and sex between EV71 and CV16 infected cases. The univariate analysis showed that the incidences of herpes of mouth, erythra of knees, and nose running in children infected by CA16 were higher than in those infected by EV71. The multivariate logistic regression analysis showed that the HFMD children who had erythra of knees had higher probability of CA16 infection.
  
  
  CONCLUSIONS
  EV71 should be considered as the pathogen in children with HFMD who have no herpes of mouth, erythra of knees, and nose running.
authors.affiliation: Beijing Center for Disease Prevention and Control, Beijing 100013, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Jia
authors.forename: Cheng-Song
authors.initials: CS
authors.lastname: Zhao
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Shuang
authors.initials: S
authors.lastname: Li
authors.forename: Dai-Tao
authors.initials: DT
authors.lastname: Zhang
authors.forename: Bai-Wei
authors.initials: BW
authors.lastname: Liu
authors.forename: Quan-Yi
authors.initials: QY
authors.lastname: Wang
authors.forename: Xin-Yu
authors.initials: XY
authors.lastname: Li
mesh_terms: D002648:Child; D002675:Child, Preschool; D003384:Coxsackievirus Infections / Q000453:epidemiology*; D029821:Enterovirus A, Human; D005260:Female; D006232:Hand, Foot and Mouth Disease / Q000453:epidemiology*; D006801:Humans; D007223:Infant; D016015:Logistic Models; D008297:Male