title: Amlodipine-induced gingival hyperplasia in a Great Dane.
abstract: A 3 yr old, 70 kg (154 lbs) female spayed Great Dane developed gingival hyperplasia after treatment of systemic hypertension with amlodipine 7.5 mg q 12 hr for 16 mo. Physical examination was unremarkable except for systemic hypertension and severe gingival hyperplasia. Amlodipine was replaced with hydralazine (0.72 mg/kg [0.32 mg/lb]). Nine months later, gingival hyperplasia was nearly resolved and hypertension was well controlled. Calcium channel blockers such as amlodipine are a rare cause of gingival hyperplasia in the canine patient. Recognition of this side effect is important because a full recovery can be achieved when the offending agent is removed.
authors.affiliation: Animal Allergy and Dermatology, North Chesapeake, VA, USA. mspariser@gmail.com
authors.forename: Marlene S
authors.initials: MS
authors.lastname: Pariser
authors.forename: Paul
authors.initials: P
authors.lastname: Berdoulay
mesh_terms: D017311:Amlodipine / Q000009:adverse effects*; D000818:Animals; D000959:Antihypertensive Agents / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000209:etiology; D004285:Dogs; D005260:Female; D005885:Gingival Hyperplasia / Q000175:diagnosis / Q000662:veterinary*; D006973:Hypertension / Q000188:drug therapy / Q000662:veterinary
chemical_list: D000959:Antihypertensive Agents; D017311:Amlodipine