title: Detection of cerebral microbleeds with quantitative susceptibility mapping in the ArcAbeta mouse model of cerebral amyloidosis.
abstract: Cerebral microbleeds (CMBs) are findings in patients with neurological disorders such as cerebral amyloid angiopathy and Alzheimer's disease, and are indicative of an underlying vascular pathology. A diagnosis of CMBs requires an imaging method that is capable of detecting iron-containing lesions with high sensitivity and spatial accuracy in the presence of potentially confounding tissue abnormalities. In this study, we investigated the feasibility of quantitative magnetic susceptibility mapping (QSM), a novel technique based on gradient-recalled echo (GRE) phase data, for the detection of CMBs in the arcAβ mouse, a mouse model of cerebral amyloidosis. Quantitative susceptibility maps were generated from phase data acquired with a high-resolution T(2)(*)-weighted GRE sequence at 9.4 T. We examined the influence of different regularization parameters on susceptibility computation; a proper adjustment of the regularization parameter minimizes streaking artifacts and preserves fine structures. In the present study, it is shown that QSM provides increased detection sensitivity of CMBs and improved contrast when compared with GRE magnitude imaging. Furthermore, QSM corrects for the blooming effect observed in magnitude and phase images and depicts both the localization and spatial extent of CMBs with high accuracy. Therefore, QSM may become an important tool for diagnosing CMBs in neurological diseases.
authors.affiliation: Institute for Biomedical Engineering, ETH and University of Zurich, Zurich, Switzerland. klohs@biomed.ee.ethz.ch
authors.forename: Jan
authors.initials: J
authors.lastname: Klohs
authors.forename: Andreas
authors.initials: A
authors.lastname: Deistung
authors.forename: Ferdinand
authors.initials: F
authors.lastname: Schweser
authors.forename: Joanes
authors.initials: J
authors.lastname: Grandjean
authors.forename: Marco
authors.initials: M
authors.lastname: Dominietto
authors.forename: Conny
authors.initials: C
authors.lastname: Waschkies
authors.forename: Roger M
authors.initials: RM
authors.lastname: Nitsch
authors.forename: Irene
authors.initials: I
authors.lastname: Knuesel
authors.forename: Jürgen R
authors.initials: JR
authors.lastname: Reichenbach
authors.forename: Markus
authors.initials: M
authors.lastname: Rudin
mesh_terms: D000465:Algorithms; D000682:Amyloid / Q000235:genetics*; D019412:Anatomy, Cross-Sectional; D000818:Animals; D001931:Brain Mapping; D016657:Cerebral Amyloid Angiopathy / Q000150:complications / Q000235:genetics* / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D003627:Data Interpretation, Statistical; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic
chemical_list: D000682:Amyloid