title: Parathyroid hormone (1-34) improves bone mineral density and glucose metabolism in Spontaneously Diabetic Torii-Lepr(fa) rats.
abstract: The Spontaneously Diabetic Torii-Lepr(fa) (SDT-fa/fa) rat, a model of obese type 2 diabetes, shows obesity, hyperglycaemia and low bone mineral density (BMD). The objective of this study is to evaluate the effects of parathyroid hormone (1-34) [PTH(1-34)] on BMD and glucose metabolism in the SDT-fa/fa rat. SDT-fa/fa rats showed obesity with hyperglycaemia and decreased serum osteocalcin levels and the tibial BMD. A 4-week treatment of PTH(1-34) (20 µg/kg/day) increased the serum osteocalcin levels and the tibial BMD, and decreased the serum glucose levels without changing the serum insulin levels. These findings indicate that PTH(1-34) improved not only BMD but also glucose metabolism in SDT-fa/fa rats. This study suggests that PTH(1-34) is a novel agent for the treatment of diabetic osteoporosis.
authors.affiliation: Biological/Pharmaceutical Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., Takatsuki, Osaka, Japan. shuichi.kimura@jt.com
authors.forename: Shuichi
authors.initials: S
authors.lastname: Kimura
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Sasase
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ohta
authors.forename: Eimei
authors.initials: E
authors.lastname: Sato
authors.forename: Mutsuyoshi
authors.initials: M
authors.lastname: Matsushita
mesh_terms: D000818:Animals; D001786:Blood Glucose; D015519:Bone Density / Q000187:drug effects*; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000235:genetics; D005947:Glucose / Q000378:metabolism*; D008297:Male; D010281:Parathyroid Hormone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001786:Blood Glucose; D010281:Parathyroid Hormone; D005947:Glucose