title: A novel splicing variant of CADM2 as a protective transcript of psoriasis.
abstract: CADM2, a candidate gene for psoriasis, was identified by a genome-wide association study using microsatellites in the Japanese population (561 cases and 561 controls). Moreover, haplotype analysis included an additional 68 SNPs and indicated that a 110-kb haplotype block was detected for the protective risk haplotype of psoriasis. We also identified an initial exon of novel splicing variants in this haplotype block. A functional analysis by qRT-PCR using RNAs from the blood of 56 cases and 64 controls significantly demonstrated an inverse correlation between expression frequencies in a novel splicing variant and the number of alleles associated with psoriasis. To confirm these results, we must perform replication studies using other ethnic groups and more functional analysis particularly for skin tissues.
authors.affiliation: Department of Dermatology, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
authors.forename: Azusa
authors.initials: A
authors.lastname: Hiruma
authors.forename: Shigaku
authors.initials: S
authors.lastname: Ikeda
authors.forename: Tadashi
authors.initials: T
authors.lastname: Terui
authors.forename: Maki
authors.initials: M
authors.lastname: Ozawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Yasumoto
authors.forename: Juichiro
authors.initials: J
authors.lastname: Nakayama
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Kubota
authors.forename: Masafumi
authors.initials: M
authors.lastname: Iijima
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Sueki
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kato
authors.forename: Emiko
authors.initials: E
authors.lastname: Akasaka
authors.forename: Norihiro
authors.initials: N
authors.lastname: Ikoma
authors.forename: Tomotaka
authors.initials: T
authors.lastname: Mabuchi
authors.forename: Shiho
authors.initials: S
authors.lastname: Tamiya
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsuyama
authors.forename: Akira
authors.initials: A
authors.lastname: Ozawa
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Inoko
authors.forename: Akira
authors.initials: A
authors.lastname: Oka
mesh_terms: D000483:Alleles; D017398:Alternative Splicing; D000595:Amino Acid Sequence; D015815:Cell Adhesion Molecules / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008969:Molecular Sequence Data; D011565:Psoriasis / Q000235:genetics*
chemical_list: C556123:CADM2 protein, human; D015815:Cell Adhesion Molecules