title: [The early diagnosis value of EV 71 IgM class antibodies in the hand, foot and mouth disease].
abstract: OBJECTIVE
  Assessment of detection of IgM antibodies for human enterovirus 71 (EV 71) in early diagnosis for the hand, foot and mouth disease (HFMD).
  
  
  METHODS
  The sera and throat swabs from 38 patients which were clinical diagnosis as HFMD, were continuous daily collected in our hospital in 2010. These specimens were detected by EV 71 IgM antibodies assay, real time RT-PCR methods for EV 71 and Enterovirus.
  
  
  RESULTS
  Among 38 HFMD patients, the cumulative positive rates of EV 71 IgM antibodies were: 60.5% on day 1, 71.1% on day 2, 81.5% in the first 3-4 days, 92.1% on day 5, 92.1% on day 6, and the positive rate of nucleic acid detected by the real time RT-PCR for EV 71 and Enterovirus were 60.5%, 73.6%.
  
  
  CONCLUSIONS
  The positive rate of EV 71 IgM antibodies in the hand, foot and mouth disease just can occur on day 1, and reach to peak on day 5, which can be used as one of indicators of early diagnosis of hand, foot and mouth disease.
authors.affiliation: Liver Failure Treatment and Research Center, 302nd Hospital of PLA, Beijing 100039, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.forename: Wei-wei
authors.initials: WW
authors.lastname: Chen
authors.forename: Yong-li
authors.initials: YL
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Tang
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.forename: Hai-bin
authors.initials: HB
authors.lastname: Wang
authors.forename: Tong-sheng
authors.initials: TS
authors.lastname: Guo
authors.forename: Min
authors.initials: M
authors.lastname: Zhao
authors.forename: Bo-an
authors.initials: BA
authors.lastname: Li
authors.forename: Yuan-li
authors.initials: YL
authors.lastname: Mao
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D042241:Early Diagnosis; D029821:Enterovirus A, Human / Q000276:immunology / Q000302:isolation & purification*; D005260:Female; D006232:Hand, Foot and Mouth Disease / Q000175:diagnosis* / Q000276:immunology / Q000821:virology; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology; D007223:Infant; D008297:Male
chemical_list: D000914:Antibodies, Viral; D007075:Immunoglobulin M