title: [Inhibition of HIV virus-like particles production by BST-2].
abstract: Recently, BST-2 has been identified as an effective cellular factor that prevents the release of human immunodeficiency virus type 1 and other enveloped viruses by tethering virus particles to the cell surface. Here, we showed that the production of HIV-1 virus-like particles was markedly inhibited by BST-2. Both the transient and stable expressing of BST-2 had the same function and Vpu rescued the release of HIV-1 VLP in the presence of human BST-2. Consistent with a direct tethering mechanism, we confirmed that proteolysis releases restricted virions and further showed that this removed the ectodomain of BST-2 from the cell surface.
authors.affiliation: State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
authors.forename: Ying-Lian
authors.initials: YL
authors.lastname: Du
authors.forename: Si-Qi
authors.initials: SQ
authors.lastname: Hu
authors.forename: Xiao-Jing
authors.initials: XJ
authors.lastname: Pang
authors.forename: Shan
authors.initials: S
authors.lastname: Cen
authors.forename: Qi
authors.initials: Q
authors.lastname: Jin
authors.forename: Fei
authors.initials: F
authors.lastname: Guo
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism*; D002460:Cell Line; D002522:Chlorocebus aethiops; D015536:Down-Regulation; D058851:GPI-Linked Proteins / Q000235:genetics / Q000378:metabolism; D015658:HIV Infections / Q000235:genetics / Q000378:metabolism* / Q000821:virology; D015497:HIV-1 / Q000235:genetics / Q000502:physiology*; D006801:Humans; D014709:Vero Cells; D014771:Virion / Q000235:genetics / Q000502:physiology; D014779:Virus Replication; D000074010:Bone Marrow Stromal Antigen 2
chemical_list: D015703:Antigens, CD; D058851:GPI-Linked Proteins; C094572:BST2 protein, human; D000074010:Bone Marrow Stromal Antigen 2