title: Mitchellenes A-E, cyclic sesquiterpenes from the Australian plant Eremophila mitchellii.
abstract: Chemical investigations of the Australian plant Eremophila mitchellii resulted in the isolation of the novel tetracyclic sesquiterpene lactones mitchellenes A-C (1-3), the new sesquiterpene acids mitchellenes D and E (4 and 5), and the previously reported natural products 14-hydroxy-6,12-muuroloadien-15-oic acid (6), casticin, and centaureidin. The chemical structures of all compounds were determined by extensive 1D/2D NMR and MS data analysis. Mitchellenes A-C are the first tetracyclic sesquiterpene lactones to be reported; a biosynthetic pathway is proposed for these unique secondary metabolites.
authors.affiliation: Eskitis Institute, Griffith University, Brisbane, QLD 4111, Australia.
authors.forename: Emma C
authors.initials: EC
authors.lastname: Barnes
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Carroll
authors.forename: Rohan A
authors.initials: RA
authors.lastname: Davis
mesh_terms: D001315:Australia; D041621:Eremophila Plant / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D007783:Lactones; D012717:Sesquiterpenes