title: Mitochondria as target of quantum dots toxicity.
abstract: Quantum dots (QDs) hold great promise in many biological applications, with the persistence of safety concerns about the environment and human health. The present work investigated the potential toxicity of CdTe QDs on the function of mitochondria isolated from rat livers by examining mitochondrial respiration, swelling, and lipid peroxidation. We observed that QDs can significantly affect the mitochondrial membrane properties, bioenergetics and induce mitochondrial permeability transition (MPT). These results will help us learn more about QDs toxicity at subcellular (mitochondrial) level.
authors.affiliation: State Key Laboratory of Virology & Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, PR China.
authors.forename: Jiahan
authors.initials: J
authors.lastname: Li
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhang
authors.forename: Qi
authors.initials: Q
authors.lastname: Xiao
authors.forename: Fangfang
authors.initials: F
authors.lastname: Tian
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Liu
authors.forename: Ran
authors.initials: R
authors.lastname: Li
authors.forename: Guangyuan
authors.initials: G
authors.lastname: Zhao
authors.forename: Fenglei
authors.initials: F
authors.lastname: Jiang
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000818:Animals; D015227:Lipid Peroxidation / Q000187:drug effects; D008563:Membrane Lipids / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects*; D008933:Mitochondrial Swelling / Q000187:drug effects; D010100:Oxygen / Q000378:metabolism; D045663:Quantum Dots; D051381:Rats
chemical_list: D008563:Membrane Lipids; D010100:Oxygen