title: Pharmacogenomic determination of genes associated with sensitivity or resistance of tumor cells to curcumin and curcumin derivatives.
abstract: Curcuma longa L. has long been used as a medicinal plant in traditional Chinese medicine against abdominal disorders. Its active constituent curcumin has anti-inflammatory, chemopreventive and cytotoxic properties. In the present investigation, we have analyzed the cytotoxic activity of curcumin and four derivatives. Among these compounds, ethoxycurcumintrithiadiazolaminomethylcarbonate was the most cytotoxic one. The curcumin-type compounds were not cross-resistant to standard anticancer drugs and were not involved in ATP-binding cassette transporter-mediated multidrug resistance. A combined approach of messenger RNA-based microarray profiling, COMPARE analyses and signaling pathway analyses identified genes as determinants of sensitivity and resistance to curcumin and specific signaling routes involved in cellular response to curcumin. These genes may be useful as biomarkers to develop individualized treatment options in the future. From a nutritional point of view, it is a thriving perspective to further investigate whether C. longa may be used as a spice to improve cancer therapy.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University of Heidelberg, Heidelberg, Germany.
authors.forename: Serkan
authors.initials: S
authors.lastname: Sertel
authors.forename: Tolga
authors.initials: T
authors.lastname: Eichhorn
authors.forename: Judith
authors.initials: J
authors.lastname: Bauer
authors.forename: Kai
authors.initials: K
authors.lastname: Hock
authors.forename: Peter K
authors.initials: PK
authors.lastname: Plinkert
authors.forename: Thomas
authors.initials: T
authors.lastname: Efferth
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D045744:Cell Line, Tumor; D003474:Curcumin / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000633:toxicity; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D006801:Humans; D010597:Pharmacogenetics
chemical_list: D018528:ATP-Binding Cassette Transporters; D000893:Anti-Inflammatory Agents; D003474:Curcumin