title: Sweet's syndrome in a neonate with non-B54 types of human leukocyte antigen.
abstract: BACKGROUND
  Sweet's syndrome (acute febrile neutrophilic dermatosis) is characterized by fever, polymorphonuclear leukocytosis of blood, painful plaques on the limbs, face and neck, and histologically a dense dermal infiltration with mature neutrophils. Sweet's syndrome is often a complication of hematologic malignant disease or drug-induced sensitivity reactions and has a significant susceptibility correlated with certain human leukocyte antigen (HLA).
  
  
  METHODS
  A 5-week-old Japanese girl with Sweet's syndrome confirmed by skin biopsy was successfully treated and HLA analysis was performed.
  
  
  RESULTS
  The patient was one of the youngest patients reported with Sweet's syndrome, suggesting the importance of the genetic background. Although the HLA types of the patient did not have B54, which was reported as a significant susceptibility correlation, structural analysis of the patient's HLAs suggested a similar possible motif for the bound peptides.
  
  
  CONCLUSIONS
  Studies on the HLA bound peptides and HLA structural analysis for patients with Sweet's syndrome would be valuable for understanding the molecular mechanism of the pathogenesis.
authors.affiliation: Department of Pediatrics, Nagahama City Hospital, Nagahama, Shiga, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Omoya
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Naiki
authors.forename: Zenichiro
authors.initials: Z
authors.lastname: Kato
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Yoshioka
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Uchida
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Taga
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Aoki
authors.forename: Hideki
authors.initials: H
authors.lastname: Deguchi
authors.forename: Naomi
authors.initials: N
authors.lastname: Kondo
mesh_terms: D005260:Female; D006680:HLA Antigens / Q000145:classification / Q000276:immunology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016463:Sweet Syndrome / Q000175:diagnosis* / Q000276:immunology*
chemical_list: D006680:HLA Antigens