title: Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter.
abstract: Sensing of RNA virus infection by the RIG-I-like receptors (RLRs) engages a complex signaling cascade that utilizes the mitochondrial antiviral signaling (MAVS) adapter protein to orchestrate the innate host response to pathogen, ultimately leading to the induction of antiviral and inflammatory responses mediated by type I interferon (IFN) and NF-κB pathways. MAVS is localized to the outer mitochondrial membrane, and has been associated with peroxisomes, the endoplasmic reticulum and autophagosomes, where it coordinates signaling events downstream of RLRs. MAVS not only plays a pivotal role in the induction of antiviral and inflammatory pathways but is also involved in the coordination of apoptotic and metabolic functions. This review summarizes recent findings related to the MAVS adapter and its essential role in the innate immune response to RNA viruses.
authors.affiliation: Terry Fox Molecular Oncology Group, Lady Davis Institute, Jewish General Hospital, Canada.
authors.forename: S Mehdi
authors.initials: SM
authors.lastname: Belgnaoui
authors.forename: Suzanne
authors.initials: S
authors.lastname: Paz
authors.forename: John
authors.initials: J
authors.lastname: Hiscott
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000276:immunology* / Q000378:metabolism; D017209:Apoptosis / Q000276:immunology; D053487:DEAD-box RNA Helicases / Q000276:immunology / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D007370:Interferon Type I / Q000276:immunology / Q000378:metabolism; D000072640:Interferon-Induced Helicase, IFIH1; D008928:Mitochondria / Q000276:immunology* / Q000378:metabolism; D051336:Mitochondrial Membranes / Q000276:immunology / Q000378:metabolism; D016328:NF-kappa B / Q000276:immunology / Q000378:metabolism; D020675:Peroxisomes / Q000276:immunology / Q000378:metabolism; D020365:RNA Helicases / Q000276:immunology / Q000378:metabolism; D012327:RNA Virus Infections / Q000276:immunology* / Q000821:virology; D012328:RNA Viruses / Q000276:immunology*; D012367:RNA, Viral / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D015534:Trans-Activators; D014157:Transcription Factors / Q000276:immunology* / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D007370:Interferon Type I; C505371:MAVS protein, human; D016328:NF-kappa B; C431552:RAI1 protein, human; D012367:RNA, Viral; D015534:Trans-Activators; D014157:Transcription Factors; C520569:DHX58 protein, human; C452815:IFIH1 protein, human; D053487:DEAD-box RNA Helicases; D000072640:Interferon-Induced Helicase, IFIH1; D020365:RNA Helicases