title: Metal-mediated tandem coassembly of collagen peptides into banded microstructures.
abstract: The ability to recapitulate the features of natural collagen at the micro- and nanoscale with novel biopolymers has the potential to lead to improved biomaterials. Herein we describe stimuli-responsive collagen-based peptides (IdaCol and HisCol) that together form higher order assemblies in the presence of added metal ions. SEM and TEM imaging of these assemblies revealed microscale petal-like and intertwined fiber morphologies, each with periodic banding on the nanometer scale. The observed banding is consistent with tandem coassembly of alternating IdaCol and HisCol triple helical blocks that may laterally associate either in or out of register to form higher order structures, and mimics the banding found in natural collagen fibers.
authors.affiliation: Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, USA.
authors.forename: Marcos M
authors.initials: MM
authors.lastname: Pires
authors.forename: David E
authors.initials: DE
authors.lastname: Przybyla
authors.forename: Charles M
authors.initials: CM
authors.lastname: Rubert Pérez
authors.forename: Jean
authors.initials: J
authors.lastname: Chmielewski
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism; D003094:Collagen / Q000737:chemistry* / Q000378:metabolism; D007477:Ions / Q000378:metabolism; D008670:Metals / Q000378:metabolism; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D007477:Ions; D008670:Metals; D010455:Peptides; D003094:Collagen