title: Design and performance of a multichannel vestibular prosthesis that restores semicircular canal sensation in rhesus monkey.
abstract: In normal individuals, the vestibular labyrinths sense head movement and mediate reflexes that maintain stable gaze and posture. Bilateral loss of vestibular sensation causes chronic disequilibrium, oscillopsia, and postural instability. We describe a new multichannel vestibular prosthesis (MVP) intended to restore modulation of vestibular nerve activity with head rotation. The device comprises motion sensors to measure rotation and gravitoinertial acceleration, a microcontroller to calculate pulse timing, and stimulator units that deliver constant-current pulses to microelectrodes implanted in the labyrinth. This new MVP incorporates many improvements over previous prototypes, including a 50% decrease in implant size, a 50% decrease in power consumption, a new microelectrode array design meant to simplify implantation and reliably achieve selective nerve-electrode coupling, multiple current sources conferring ability to simultaneously stimulate on multiple electrodes, and circuitry for in vivo measurement of electrode impedances. We demonstrate the performance of this device through in vitro bench-top characterization and in vivo physiological experiments with a rhesus macaque monkey.
authors.affiliation: Emory School of Medicine, Atlanta, GA 30322, USA.
authors.forename: Bryce
authors.initials: B
authors.lastname: Chiang
authors.forename: Gene Y
authors.initials: GY
authors.lastname: Fridman
authors.forename: Chenkai
authors.initials: C
authors.lastname: Dai
authors.forename: Mehdi A
authors.initials: MA
authors.lastname: Rahman
authors.forename: Charles C
authors.initials: CC
authors.lastname: Della Santina
mesh_terms: D000054:Acceleration; D000465:Algorithms; D000669:Amplifiers, Electronic; D000818:Animals; D003201:Computers; D004558:Electric Stimulation; D004566:Electrodes; D004581:Electronics; D018069:Hair Cells, Vestibular / Q000502:physiology; D008253:Macaca mulatta; D019736:Prostheses and Implants; D011474:Prosthesis Design / Q000379:methods*; D019919:Prosthesis Implantation; D012399:Rotation; D012665:Semicircular Canals / Q000502:physiology*; D012677:Sensation; D012984:Software; D014725:Vestibular Nerve / Q000502:physiology; D014722:Vestibule, Labyrinth / Q000502:physiology* / Q000601:surgery; D059015:Wireless Technology