title: Comparative efficacy of probiotic yoghurt and clindamycin in treatment of bacterial vaginosis in pregnant women: a randomized clinical trial.
abstract: OBJECTIVE
  This study was performed to determine the comparative efficacy of probiotic yoghurt and clindamycin in the treatment of bacterial vaginosis in pregnant women in the third trimester.
  
  
  METHODS
  This randomized clinical trial was performed as an open-label study. 310 symptomatic patients with BV were recruited. Diagnosis of BV was through Amsel criteria. The patients were randomly assigned to receive either probiotic yoghurt (100 g twice a day/week) or orally administered clindamycin (300 mg twice a day/week).
  
  
  RESULTS
  Ten patients in probiotic group and 9 subjects in clindamycin group had symptom recurrence (p > 0.05). 132 patients in probiotic group and 105 subjects in clindamycin group had pH decrease (p < 0.0001). 140 patients in probiotic group and 141 subjects in clindamycin group had complete symptomatic cure (p > 0.05). Twelve patients in probiotic group and seven subjects in clindamycin group had preterm birth. Nine women in probiotic group and five subjects in clindamycin group had PROM (p > 0.05).
  
  
  CONCLUSIONS
  According to the obtained results, it may be concluded that probiotics would have a good efficacy in the treatment of bacterial vaginosis in pregnancy leading to decreased burden of subsequent preterm birth.
authors.affiliation: Maternal-Fetal & Neonatal Research Center and Breast Feeding Research Center, Tehran University of Medical Sciences, Tehran, Iran. hantoushzadeh@tums.ac.ir
authors.forename: Sedigheh
authors.initials: S
authors.lastname: Hantoushzadeh
authors.forename: Fateme
authors.initials: F
authors.lastname: Golshahi
authors.forename: Pouya
authors.initials: P
authors.lastname: Javadian
authors.forename: Soghra
authors.initials: S
authors.lastname: Khazardoost
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Aram
authors.forename: Shahrzad
authors.initials: S
authors.lastname: Hashemi
authors.forename: Bahare
authors.initials: B
authors.lastname: Mirarmandehi
authors.forename: Sedigheh
authors.initials: S
authors.lastname: Borna
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002981:Clindamycin / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000628:therapy*; D011263:Pregnancy Trimester, Third; D047928:Premature Birth / Q000517:prevention & control; D019936:Probiotics / Q000627:therapeutic use*; D016896:Treatment Outcome; D016585:Vaginosis, Bacterial / Q000628:therapy*; D015014:Yogurt / Q000382:microbiology*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D002981:Clindamycin