title: Adenomatous tumors of the middle ear and temporal bone: clinical, morphological and tumor biological characteristics of challenging neoplastic lesions.
abstract: Adenomatous tumors of the middle ear and temporal bone are rare tumors. In this retrospective study, we examined nine patients who underwent surgery for an adenomatous tumor of the middle ear, mastoid cavity or eustachian tube. In seven patients, a middle ear adenoma (MEA) and in two patients an aggressive papillary tumor (APT) was diagnosed. We report the clinical, radiologic, morphologic, immunohistochemical and DNA image cytometrical characteristics that can help to correctly classify these tumors. Therapy consisted of surgical excision of the tumors in eight cases. In one elderly patient, only a large biopsy was taken, because this patient suffered from cardial and kidney disorders and was not suitable for an extended surgical approach. This patient received stereotactic radiotherapy. Seven patients underwent planned second look operation. Recurrences occurred in three patients (one with APT, two with MEA), whereas in two of these cases rather a residual tumor due to initial incomplete tumor resection occurred. By image analysis, DNA cytometry MEA were considered benign, whereas the appearance of aneuploid tumor cells in APT confirmed these tumors as low grade malignant lesions. The proliferation rates were equally low in both entities. APT and MEA are tumor entities which can only be correctly classified by a synopsis of histopathology, immunohistochemistry and DNA image cytometry. The recommended therapy is the complete tumor excision. In cases of APT, von Hippel-Lindau syndrome has to be excluded.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, KRH Nordstadt Clinic, Academic Hospital, Haltenhoffstr. 41, 30167, Hannover, Germany. hno-nordstadt@krh.eu
authors.forename: M
authors.initials: M
authors.lastname: Duderstadt
authors.forename: Christine
authors.initials: C
authors.lastname: Förster
authors.forename: H-J
authors.initials: HJ
authors.lastname: Welkoborsky
authors.forename: H
authors.initials: H
authors.lastname: Ostertag
mesh_terms: D018254:Adenomatoid Tumor / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D004273:DNA, Neoplasm / Q000032:analysis; D003937:Diagnosis, Differential; D004428:Ear Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D004432:Ear, Middle; D005260:Female; D005434:Flow Cytometry; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D038781:Otoscopy; D012189:Retrospective Studies; D013701:Temporal Bone; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014433:Tympanoplasty / Q000379:methods*
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm