title: [Effects of histamine on contractile activity of lymphatic node capsules. The NO role].
abstract: Effects of histamine (10(-9)--5 x 10(-5) M) on the phase and tonic contractile activity of capsular smooth muscles of isolated bovine mesentery lymph node were investigated. Dual dose-depended effect of histamine was found. Low concentrations of histamine less than 10(-7) M caused a decrease of contractile activity, whereas higher concentrations of histamine (more than 5 x 10(-7) M) resulted in increase of the phase and tonic contractions. Both H1- and H2-receptors of smooth muscle cells are involved in the response. Much of the relaxing histamine-induced response is produced by the stimulation of the endothelial cells. We believe that activating effect of histamine is due to the excitation of H1-receptors located on the membrane of myocytes, whereas its inhibitory effect occurs in two ways: 1) via excitation of H2-receptors located on the membrane of myocytes; 2) via stimulation of the NO production by the endothelial cells of lymph node sinus.
authors.forename: M N
authors.initials: MN
authors.lastname: Pan'kova
authors.forename: G I
authors.initials: GI
authors.lastname: Lobov
authors.forename: V N
authors.initials: VN
authors.lastname: Chikhman
authors.forename: S D
authors.initials: SD
authors.lastname: Solnyshkin
mesh_terms: D000818:Animals; D002417:Cattle; D002462:Cell Membrane / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D006632:Histamine / Q000494:pharmacology* / Q000502:physiology*; D008198:Lymph Nodes / Q000187:drug effects / Q000502:physiology*; D009119:Muscle Contraction / Q000502:physiology*; D009130:Muscle, Smooth / Q000502:physiology; D009569:Nitric Oxide / Q000502:physiology*; D011969:Receptors, Histamine H1 / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D011970:Receptors, Histamine H2 / Q000187:drug effects / Q000378:metabolism / Q000502:physiology
chemical_list: D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D009569:Nitric Oxide; D006632:Histamine