title: Virus-host interactomes and global models of virus-infected cells.
abstract: Novel high-throughput technologies such as yeast two-hybrid and RNA interference (RNAi) screens provide the tools to study interactions between viral proteins and the host on a genomic scale. In this review, we provide an overview of studies in which these technologies were applied and of computational approaches for the analysis of the identified viral interactors in the context of the host cell. The results of these studies illustrate the advantages of integrative systems biology approaches in the investigation of viral pathogens.
authors.affiliation: Institut für Pharmazie und Molekulare Biotechnologie, Universität Heidelberg, 69120 Heidelberg, Germany.
authors.forename: Caroline C
authors.initials: CC
authors.lastname: Friedel
authors.forename: Jürgen
authors.initials: J
authors.lastname: Haas
mesh_terms: D000818:Animals; D002460:Cell Line; D054884:Host-Pathogen Interactions / Q000235:genetics / Q000276:immunology; D006801:Humans; D040901:Proteomics; D049490:Systems Biology / Q000379:methods*; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism*; D014777:Virus Diseases / Q000473:pathology* / Q000821:virology; D014780:Viruses / Q000187:drug effects / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*
chemical_list: D014764:Viral Proteins