title: TRPV1 expressing extrinsic primary sensory neurons play a protective role in mouse oxazolone-induced colitis.
abstract: TRPV1 expressing sensory neurons which have been considered to be largely associated with neurogenic inflammation were chemically denervated by capsaicin treatment in neonatal mice. However, neonatal capsaicin treatment aggravated mouse oxazolone-induced colitis, and did not affect the expression of calcitonin gene-related peptide (CGRP)- or substance P-immunoreactive nerve fibers in the colon. Meanwhile, the capsaicin-induced contraction was absent in the colon of neonatal capsaicin treatment mouse. These results suggest a protective role of TRPV1 expressing extrinsic sensory neurons in oxazolone-induced colitis and the involvement of some neurotransmitter other than CGRP and substance P in the pathogenesis of the colitis.
authors.affiliation: Division of Gastroinstestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan. d1061203@ems.u-toyama.ac.jp
authors.forename: Jaemin
authors.initials: J
authors.lastname: Lee
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Kuramoto
authors.forename: Makoto
authors.initials: M
authors.lastname: Kadowaki
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D017763:Autonomic Denervation / Q000009:adverse effects; D003092:Colitis / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology*; D003106:Colon / Q000294:innervation / Q000503:physiopathology*; D004195:Disease Models, Animal; D017615:Enteric Nervous System / Q000166:cytology / Q000254:growth & development / Q000502:physiology*; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011984:Sensory Receptor Cells / Q000187:drug effects / Q000502:physiology*; D050916:TRPV Cation Channels / Q000819:agonists / Q000502:physiology*
chemical_list: D050916:TRPV Cation Channels; C493921:TRPV1 protein, mouse