title: The protective effect of flaxseed oil on lead acetate-induced renal toxicity in rats.
abstract: Lead is a toxic metal inducing many destructive effects leading to a broad range of physiological, biochemical, and neurological dysfunctions in humans. Here, we investigated the effects of flaxseed oil (1000 mg/kg) on the outcome of renal cytotoxicity induced by lead acetate (20mg/kg) in male rats. Lead induced injury of the renal tissue. This was evidenced (i) as increases in lead concentration in the kidney, (ii) as increases in the histopathological damage of the renal tissue, (iii) as increases in uric acid, urea and creatinine, (iv) as increases in lipid peroxidation, nitric oxide and reactive oxygen species, and (v) as lowered glutathione levels and decreased activities of catalase and superoxide dismutase, glutathione reductase, glutathione-S-transferase, and glutathione peroxidase, respectively. All these lead-induced parameters were significantly altered during flaxseed oil treatment. Therefore, our study suggests the role of flaxseed oil in limiting renal cytotoxicity-induced by lead acetate as a model for lead toxicity.
authors.affiliation: Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt. aest1977@hotmail.com
authors.forename: Ahmed E
authors.initials: AE
authors.lastname: Abdel Moneim
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Dkhil
authors.forename: Saleh
authors.initials: S
authors.lastname: Al-Quraishy
mesh_terms: D000818:Animals; D004798:Enzymes / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D008043:Linseed Oil; D015227:Lipid Peroxidation; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D009942:Organometallic Compounds / Q000633:toxicity*; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D004798:Enzymes; D009942:Organometallic Compounds; D017382:Reactive Oxygen Species; D009569:Nitric Oxide; D008043:Linseed Oil; D005978:Glutathione; C008261:lead acetate