title: Discovery and identification of 2-phenylethyl 2,6-dihydroxybenzoate as a natural lipid-lowering lead.
abstract: Guided by lipid-lowering assays, a new compound (1, 2-phenylethyl 2,6-dihydroxybenzoate) was isolated from the ethanolic extract of Geophila herbacea. The structure of 1 was determined unambiguously by spectral data interpretation and confirmed by X-ray crystallographic analysis. Preliminary dose-dependency of 1 verified its lipid-lowering bioactivity in vitro. A facile chemical synthesis for 1 was performed to provide a practical approach for further studies on structure-activity relationship.
authors.affiliation: Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, P. R. China. yinggluo@cib.ac.cn
authors.forename: Yinggang
authors.initials: Y
authors.lastname: Luo
authors.forename: Guangzhou
authors.initials: G
authors.lastname: Li
authors.forename: Guoyou
authors.initials: G
authors.lastname: Li
authors.forename: Jufang
authors.initials: J
authors.lastname: Yan
authors.forename: Jinhai
authors.initials: J
authors.lastname: Yi
authors.forename: Guolin
authors.initials: G
authors.lastname: Zhang
mesh_terms: D018360:Crystallography, X-Ray; D000431:Ethanol / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D062385:Hydroxybenzoates / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D019666:Rubiaceae / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D013329:Structure-Activity Relationship
chemical_list: C571324:2-phenylethyl 2,6-dihydroxybenzoate; D062385:Hydroxybenzoates; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D000431:Ethanol