title: Protracted bacterial bronchitis in young children: association with airway malacia.
abstract: OBJECTIVE
  To examine associated findings and clinical outcome in young children with prolonged cough, wheeze, and/or noisy breathing in whom high colony counts of potentially pathogenic bacteria were cultured from bronchoalveolar lavage (BAL) during diagnostic flexible fiberoptic bronchoscopy.
  
  
  METHODS
  This was a retrospective review of all medical records of children from infancy to 60 months of age seen in our specialty clinic from 1999 to 2009 with protracted cough, wheeze, and/or noisy breathing in whom BAL found ≥ 10(4) colony forming units per milliliter of potentially pathogenic bacteria. Children with other major diagnoses were excluded.
  
  
  RESULTS
  With quantitative culture from BAL, ≥ 10(4) colony forming units per milliliter of Streptococcus pneumoniae, Haemophilus influenza, or Moraxella catarrhalis, separately or in combination, were found in 70 children. Neutrophilia was present in 87% of BALs. Tracheomalacia, bronchomalacia, or both was present in 52 children (74%). Symptoms were eliminated with antibiotics in all 61 children with follow-up data. Relapse and subsequent successful re-treatment occurred in 43 children.
  
  
  CONCLUSIONS
  High colony counts of potentially pathogenic bacteria associated with neutrophilia in the BAL identifies protracted bacterial bronchitis. The predominance of airway malacia in these patients suggests an etiologic role for those airway anomalies. The potential for chronic airway damage from protracted bacterial bronchitis warrants further investigation.
authors.affiliation: Pediatric Department, University of Iowa Children's Hospital, Iowa City, IA, USA.
authors.forename: Michelle
authors.initials: M
authors.lastname: Kompare
authors.forename: Miles
authors.initials: M
authors.lastname: Weinberger
mesh_terms: D001991:Bronchitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D055091:Bronchomalacia / Q000150:complications*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D055090:Tracheomalacia / Q000150:complications*