title: Practical and stereoselective synthesis of β-amino sulfones from alkyl phenyl sulfones and N-(tert-butylsulfinyl) aldimines.
abstract: A practical and straightforward approach for the highly stereoselective synthesis of β-amino sulfones was developed. With lithium bis(trimethylsilyl)amide as the base, the corresponding sulfone-stabilized carbanion derived from alkylphenyl sulfone can be transferred to N-(tert-butylsulfinyl) aldimines in excellent yields and with high diastereoselectivity.
authors.affiliation: School of Environment Science and Engineering, Shanghai Jiaotong University, Shanghai, 200240, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.forename: Ya
authors.initials: Y
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Wenrui
authors.initials: W
authors.lastname: Zheng
authors.forename: Pei
authors.initials: P
authors.lastname: Zhou
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Sun
mesh_terms: D060326:Chemistry Techniques, Synthetic; D018360:Crystallography, X-Ray; D007097:Imines / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism; D013450:Sulfones / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D007097:Imines; D013450:Sulfones