title: The role of blood flow distribution in the regulation of cerebral oxygen availability in fetal growth restriction.
abstract: Fetal growth restriction (FGR) elicits hemodynamic compensatory mechanisms in the fetal circulation. These mechanisms are complex and their effect on the cerebral oxygen availability is not fully understood. To quantify the contribution of each compensatory mechanism to the fetal cerebral oxygen availability, a mathematical model of the fetal circulation was developed. The model was based on cardiac-output distribution in the fetal circulation. The compensatory mechanisms of FGR were simulated and their effects on cerebral oxygen availability were analyzed. The mathematical analysis included the effects of cerebral vasodilation, placental resistance to blood flow, degree of blood shunting by the ductus venosus and the effect of maternal-originated placental insufficiency. The model indicated a unimodal dependency between placental blood flow and cerebral oxygen availability. Optimal cerebral oxygen availability was achieved when the placental blood flow was mildly reduced compared to the normal flow. This optimal ratio was found to increase as the hypoxic state of FGR worsens. The model indicated that cerebral oxygen availability is increasingly dependent on the cardiac output distribution as the fetus gains weight.
authors.affiliation: Department of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Oded
authors.initials: O
authors.lastname: Luria
authors.forename: Jacob
authors.initials: J
authors.lastname: Bar
authors.forename: Michal
authors.initials: M
authors.lastname: Kovo
authors.forename: Gustavo
authors.initials: G
authors.lastname: Malinger
authors.forename: Abraham
authors.initials: A
authors.lastname: Golan
authors.forename: Ofer
authors.initials: O
authors.lastname: Barnea
mesh_terms: D001698:Biomedical Engineering; D001921:Brain / Q000098:blood supply* / Q000378:metabolism*; D002302:Cardiac Output / Q000502:physiology; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology / Q000503:physiopathology*; D005333:Fetus / Q000098:blood supply* / Q000503:physiopathology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D010100:Oxygen / Q000097:blood* / Q000378:metabolism*; D010920:Placenta / Q000098:blood supply; D011247:Pregnancy; D012039:Regional Blood Flow / Q000502:physiology*
chemical_list: D010100:Oxygen