title: Femtosecond laser treatment of the crystalline lens: a 1-year study of possible cataractogenesis in minipigs.
abstract: BACKGROUND
  To investigate the long-term stability and possible cataractogenesis after femtosecond laser treatment of the crystalline lens.
  
  
  METHODS
  The crystalline lenses of ten Göttingen minipigs® underwent femtosecond laser treatment. During a subsequent 1-year follow-up, the pigs were monitored by means of slit-lamp examination of the anterior segment and Scheimpflug imaging of the lens.
  
  
  RESULTS
  No laser-induced cataractogenesis was observed during the 1-year follow-up. The laser pattern showed a stable appearance under all examination devices.
  
  
  CONCLUSIONS
  Femtosecond laser treatment seems to be no trigger for cataract formation. Moreover, the long-term stability of the laser pattern makes it suitable for applications such as presbyopia treatment.
authors.affiliation: Institute of Applied Physics, Friedrich-Schiller-Universität Jena, Max-Wien-Platz 1, 07743, Jena, Germany. Roland.Ackermann@uni-jena.de
authors.forename: Roland
authors.initials: R
authors.lastname: Ackermann
authors.forename: Kathleen S
authors.initials: KS
authors.lastname: Kunert
authors.forename: Robert
authors.initials: R
authors.lastname: Kammel
authors.forename: Sabine
authors.initials: S
authors.lastname: Bischoff
authors.forename: Stephanie C
authors.initials: SC
authors.lastname: Bühren
authors.forename: Harald
authors.initials: H
authors.lastname: Schubert
authors.forename: Marcus
authors.initials: M
authors.lastname: Blum
authors.forename: Stefan
authors.initials: S
authors.lastname: Nolte
mesh_terms: D000818:Animals; D002386:Cataract / Q000209:etiology / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D005500:Follow-Up Studies; D053685:Laser Therapy / Q000295:instrumentation*; D007908:Lens, Crystalline / Q000473:pathology / Q000601:surgery*; D013552:Swine; D013556:Swine, Miniature; D013997:Time Factors; D016896:Treatment Outcome