title: Competitive inhibitor of cellular α-glucosidases protects mice from lethal dengue virus infection.
abstract: Dengue virus infection causes diseases in people, ranging from the acute febrile illness dengue fever, to life-threatening dengue hemorrhagic fever/dengue shock syndrome. We previously reported that a host cellular α-glucosidases I and II inhibitor, imino sugar CM-10-18, potently inhibited dengue virus replication in cultured cells, and significantly reduced viremia in dengue virus infected AG129 mice. In this report we show that CM-10-18 also significantly protects mice from death and/or disease progress in two mouse models of lethal dengue virus infection. Our results thus provide a strong support for the development of CM-10-18 or its derivatives as antiviral agents to treat servere dengue virus infections.
authors.affiliation: Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, PA 18902, United States. jinhong.chang@drexelmed.edu
authors.forename: Jinhong
authors.initials: J
authors.lastname: Chang
authors.forename: Wouter
authors.initials: W
authors.lastname: Schul
authors.forename: Andy
authors.initials: A
authors.lastname: Yip
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Xu
authors.forename: Ju-Tao
authors.initials: JT
authors.lastname: Guo
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Block
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage*; D003715:Dengue / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000517:prevention & control*; D004791:Enzyme Inhibitors / Q000008:administration & dosage*; D065089:Glycoside Hydrolase Inhibitors; D051379:Mice; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors