title: Helicobacter pylori and oral cancer: possible association in a preliminary case control study.
abstract: Oral cancer is the most common cancer diagnosed in Indian men and is the leading cause of cancer deaths. Helicobacter pylori have been reported to be present in 0-40% of the cases with head neck cancer. A higher percentage has been identified in laryngeal and pharangeal cancer. We here carried out a hospital-based, case- control study of 20 patients with newly diagnosed oral cancer and 20 healthy controls without any cancer to evaluate associations between H pylori infection and oral cancer using culture and 16sRNA PCR technique for bacterial identification. H pylori was isolated from the culture of three cases and one control, while three cases and two control showed PCR positivity for H Pylori 16sRNA. The odds ratio by culture was 3.0, 95% CI 0.34- 26.4 and 1.5, 95% CI 0.28-8.03 by PCR. None of the observed odds ratio was statistically significant. However, the results of this pilot study suggest a possible association of H. pylori with an increased risk of oral cancer. Additional studies in larger populations are necessary to confirm and to quantify this possible association more accurately.
authors.affiliation: Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
authors.forename: Anand
authors.initials: A
authors.lastname: Dayama
authors.forename: Vineeta
authors.initials: V
authors.lastname: Srivastava
authors.forename: Mridula
authors.initials: M
authors.lastname: Shukla
authors.forename: Royana
authors.initials: R
authors.lastname: Singh
authors.forename: Manoj
authors.initials: M
authors.lastname: Pandey
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000382:microbiology; D016022:Case-Control Studies; D004269:DNA, Bacterial / Q000302:isolation & purification; D005260:Female; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000382:microbiology*; D010865:Pilot Projects; D012336:RNA, Ribosomal, 16S / Q000032:analysis; D012307:Risk Factors
chemical_list: D004269:DNA, Bacterial; D012336:RNA, Ribosomal, 16S