title: Intragenomic bet-hedging.
abstract: The notion of intragenomic bet-hedging is introduced by modeling a system where one locus is seen as setting the "environment" for selection in a two-locus genetic system. Using a spatially structured simulation model I show that bet-hedging alleles with a lower mean fitness and lower variance of fitness across genotypes at a different locus can go to fixation, potentially providing a mechanism for the reduction of severe heterozygote advantage.
authors.affiliation: Norwegian Institute for Water Research, Gaustadalléen 21, 0349 Oslo, Norway. jostein.starrfelt@niva.no
authors.forename: Jostein
authors.initials: J
authors.lastname: Starrfelt
mesh_terms: D000483:Alleles; D004777:Environment; D019143:Evolution, Molecular; D056084:Genetic Fitness / Q000235:genetics*; D056426:Genetic Loci / Q000235:genetics; D016678:Genome / Q000235:genetics*; D006579:Heterozygote; D008957:Models, Genetic