title: A retinoic acid-dependent checkpoint in the development of CD4+ T cell-mediated immunity.
abstract: It is known that vitamin A and its metabolite, retinoic acid (RA), are essential for host defense. However, the mechanisms for how RA controls inflammation are incompletely understood. The findings presented in this study show that RA signaling occurs concurrent with the development of inflammation. In models of vaccination and allogeneic graft rejection, whole body imaging reveals that RA signaling is temporally and spatially restricted to the site of inflammation. Conditional ablation of RA signaling in T cells significantly interferes with CD4(+) T cell effector function, migration, and polarity. These findings provide a new perspective of the role of RA as a mediator directly controlling CD4(+) T cell differentiation and immunity.
authors.affiliation: Department of Microbiology and Immunology, Dartmouth Medical School, Norris Cotton Cancer Center, Lebanon, NH 03756, USA.
authors.forename: Karina
authors.initials: K
authors.lastname: Pino-Lagos
authors.forename: Yanxia
authors.initials: Y
authors.lastname: Guo
authors.forename: Chrysothemis
authors.initials: C
authors.lastname: Brown
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Alexander
authors.forename: Raúl
authors.initials: R
authors.lastname: Elgueta
authors.forename: Kathryn A
authors.initials: KA
authors.lastname: Bennett
authors.forename: Victor
authors.initials: V
authors.lastname: De Vries
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Nowak
authors.forename: Rune
authors.initials: R
authors.lastname: Blomhoff
authors.forename: Shanthini
authors.initials: S
authors.lastname: Sockanathan
authors.forename: Roshantha A
authors.initials: RA
authors.lastname: Chandraratna
authors.forename: Ethan
authors.initials: E
authors.lastname: Dmitrovsky
authors.forename: Randolph J
authors.initials: RJ
authors.lastname: Noelle
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000276:immunology / Q000378:metabolism / Q000494:pharmacology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology*; D002465:Cell Movement / Q000187:drug effects / Q000502:physiology*; D006084:Graft Rejection / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D007111:Immunity, Cellular / Q000187:drug effects / Q000502:physiology*; D007114:Immunization; D007249:Inflammation / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D018448:Models, Immunological; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D016038:Skin Transplantation / Q000276:immunology; D014184:Transplantation, Homologous; D014212:Tretinoin / Q000276:immunology* / Q000378:metabolism / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D014212:Tretinoin