title: Exercise-induced pulmonary hemorrhage in horses: the role of pulmonary veins.
abstract: While airway endoscopy and bronchoalveolar lavage are the methodsof choice for diagnosing exercise-induced pulmonary hemorrhage (EIPH), these techniques do not allow accurate evaluation of the severity of bleeding. EIPH pathology is characterized by occlusive remodeling of pulmonary veins. Affected veins have large collagen deposits in their walls, which reduces their lumens. In the caudodorsal regions, pulmonary vein wall remodeling is associated with hemosiderin accumulation, bronchial circulation angiogenesis, and fibrosis of the alveolar interstitium, bronchovascular bundle, septa, and pleura. During exercise, venous occlusion increases regional pulmonary capillary pressure, likely causing capillary rupture and resulting in bleeding.
authors.affiliation: Michigan State University, USA.
authors.forename: Frederik
authors.initials: F
authors.lastname: Derksen
authors.forename: Kurt
authors.initials: K
authors.lastname: Williams
authors.forename: Alice
authors.initials: A
authors.lastname: Stack
mesh_terms: D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D002196:Capillaries / Q000473:pathology; D005665:Furosemide / Q000627:therapeutic use; D006470:Hemorrhage / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D006734:Horse Diseases / Q000175:diagnosis* / Q000188:drug therapy; D006736:Horses; D007249:Inflammation / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary; D008171:Lung Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D018384:Oxidative Stress; D010805:Physical Conditioning, Animal / Q000009:adverse effects*; D011667:Pulmonary Veins / Q000473:pathology*
chemical_list: D005665:Furosemide