title: Unique growth pattern in papillary carcinoma of the thyroid gland mimicking adenoid cystic carcinoma.
abstract: We report here three cases of papillary thyroid carcinoma (PTC) with hyaline globules as seen in adenoid cystic carcinoma of the salivary glands. This unique growth pattern was seen in two cases of columnar cell and one case of cribriform morular variant of PTC. Fine-needle aspiration was performed in two cases. By immunohistochemistry, all cases demonstrated expression of TTF-1 and thyroglobulin confirming follicular cell derivation. It is important to be aware of this unusual growth pattern in thyroid carcinomas; immunohistochemistry is warranted for rendering accurate cytopathologic and histopathologic diagnosis.
authors.affiliation: Department of Pathology & Laboratory Medicine, University of Pennsylvania Medical Center, 6 Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA. baloch@mail.med.upenn.edu
authors.forename: Zubair W
authors.initials: ZW
authors.lastname: Baloch
authors.forename: Jeremy P
authors.initials: JP
authors.lastname: Segal
authors.forename: Virginia A
authors.initials: VA
authors.lastname: Livolsi
mesh_terms: D000328:Adult; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism; D044963:Biopsy, Fine-Needle; D003528:Carcinoma, Adenoid Cystic / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D002291:Carcinoma, Papillary / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006818:Hyalin / Q000378:metabolism; D007150:Immunohistochemistry; D008875:Middle Aged; D009687:Nuclear Proteins / Q000378:metabolism; D013954:Thyroglobulin / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D009218:Myosins
chemical_list: D051017:Apoptosis Regulatory Proteins; D009687:Nuclear Proteins; D013954:Thyroglobulin; C407152:MYO18A protein, human; D009218:Myosins