title: Effects of tamsulosin, solifenacin, and combination therapy for the treatment of ureteral stent related discomforts.
abstract: OBJECTIVE
  To evaluate the effect of tamsulosin, solifenacin, and combination therapy of two agents in improving the lower urinary tract symptoms of patients with indwelling double-J ureteral stents.
  
  
  METHODS
  A total of 168 patients underwent placement of a double-J ureteral stent after retrograde ureteroscopy for urinary stone disease. All patients received polyurethane double-J ureteral stents (6 Fr, 24 or 26 cm), which were removed a mean of 14 days postoperatively. A total of 48 patients were given no medication (Group 1), 43 patients were given tamsulosin 0.2 mg once daily (Group 2), 45 patients were given solifenacin 5 mg once daily (Group 3), and 32 patients were given a combination of two agents postoperatively (Group 4). International Prostate Symptom Score/quality of life (IPSS/QoL) and visual analogue pain scale (VAPS) questionnaires were completed by each patient at 1 day postoperatively and on the day of stent removal.
  
  
  RESULTS
  In the total group of patients, the mean age was 50.24±12.90 years. There was a significant difference in the IPSS total score between group 1 and groups 3 and 4. Group 4 also differed significantly from group 1 in the irritative subscore. The obstructive subscore differed between groups 2 and 4 and group 1. There was a statistically significant difference between group 1 and group 4 in the QoL score. There were no significant differences in the VAPS.
  
  
  CONCLUSIONS
  Combination therapy with tamsulosin and solifenacin improved both irritative and obstructive symptoms more than in the other groups. Combination therapy should be strongly considered for patients who complain of stent-related symptoms.
authors.affiliation: Department of Urology, Hangyang University College of Medicine, Seoul, Korea.
authors.forename: Kyoung Taek
authors.initials: KT
authors.lastname: Lim
authors.forename: Yong Tae
authors.initials: YT
authors.lastname: Kim
authors.forename: Tchun Yong
authors.initials: TY
authors.lastname: Lee
authors.forename: Sung Yul
authors.initials: SY
authors.lastname: Park