title: Enrichment of invariant natural killer T cells in the bone marrow of visceral leishmaniasis patients.
abstract: Lipid antigens of Leishmania donovani like lipophosphoglycans are shown as a potent ligand for the activation of invariant natural killer T (iNKT) cells. It is reported that activation of iNKT cells augments the disease pathology in experimental visceral leishmaniasis (VL). In this study, we demonstrate the enrichment of iNKT cells in the bone marrow, one of the disease sites among patients with VL.
authors.affiliation: Department of Transplant Immunology and Immunogenetics, All India Institutes of Medical Sciences, Ansari Nagar, New Delhi, India.
authors.forename: A K
authors.initials: AK
authors.lastname: Rai
authors.forename: C P
authors.initials: CP
authors.lastname: Thakur
authors.forename: T
authors.initials: T
authors.lastname: Seth
authors.forename: D K
authors.initials: DK
authors.lastname: Mitra
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000276:immunology* / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006017:Glycolipids / Q000276:immunology; D006801:Humans; D007893:Leishmania donovani / Q000276:immunology*; D007898:Leishmaniasis, Visceral / Q000276:immunology* / Q000473:pathology*; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D055611:Natural Killer T-Cells / Q000276:immunology*; D010743:Phospholipids / Q000276:immunology; D055815:Young Adult
chemical_list: D006017:Glycolipids; D010743:Phospholipids