title: A case of rapid-growing anaplastic meningiomas.
abstract: Meningiomas are tumours originating from the leptomeningeal covering of the brain and spinal cord and are generally benign and slow growing. Rarely, they show malignant anaplastic characteristics with a high recurrence rate. A number of factors have been reported to predict this high recurrence. Such factors are histopathological ones, such as necrosis and hypercellularity, the World Health Organization (WHO) grade, mitotic index, positivity of proliferation markers (Ki-67 or MIB-1), clinical parameters such as age, gender, localisation, cytogenetic factors and radiation treatment. The present case reports a patient with a giant meningioma over the right frontal lobe who had almost all possible negative prognostic parameters and showed an explosive multifocal recurrence in a timespan of about 5 months.
authors.affiliation: University Hospital Kiel, Neurosurgery, Schittenhelmstrasse 10, Kiel, 24105, Germany.
authors.forename: Athanasios K
authors.initials: AK
authors.lastname: Petridis
authors.forename: Alexandros
authors.initials: A
authors.lastname: Doukas
authors.forename: Mehran
authors.initials: M
authors.lastname: Mahvash
authors.forename: Lutz
authors.initials: L
authors.lastname: Dörner
authors.forename: Heinz Hermann
authors.initials: HH
authors.lastname: Hugo
authors.forename: Hubertus Maximilian
authors.initials: HM
authors.lastname: Mehdorn