title: Direct C2-alkylation of azoles with alcohols and ethers through dehydrogenative cross-coupling under metal-free conditions.
abstract: A metal-free novel, simple, and highly efficient method for the direct C2-alkylation of azoles with alcohols and ethers has been developed on the basis of an oxidative C-H activation process. The dehydrogenative C-C cross-coupling reactions of α-position sp(3) C-H in alcohols and ethers with the 2-position sp(2) C-H in azoles proceeded smoothly in the presence of tert-butyl hydroperoxide (TBHP) under neat reaction conditions, which generated the corresponding products in good yields.
authors.affiliation: Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: He
authors.forename: Lin
authors.initials: L
authors.lastname: Yu
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Wang
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000478:Alkylation; D001393:Azoles / Q000737:chemistry*; D004987:Ethers / Q000737:chemistry*; D006865:Hydrogenation; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D000438:Alcohols; D001393:Azoles; D004987:Ethers