title: [Expressions of OCT4 and CD133 and their correlation in colonic cancer].
abstract: OBJECTIVE
  To investigate the expressions of Oct4 and CD133 and their correlation in colonic cancer.
  
  
  METHODS
  The expression of Oct4 and CD133 were detected by immunohistochemistry in 30 colon cancer specimens and the paired adjacent tissues.
  
  
  RESULTS
  The positivity rates of Oct4 and CD133 expression were 83.3% (25/30) and 73.3% (22/30) in colonic cancer tissue, respectively, and their expressions were positively correlated (r=0.586, P<0.05). The matched adjacent tissues showed significantly lower levels of Oct4 and CD133 expressions (P<0.01).
  
  
  CONCLUSIONS
  The expressions of Oct4 and CD133 are upregulated in colonic cancer compared with those in the adjacent tissues and show a positive correlation. Oct4 and CD133 may play an important role in the development of colon cancer.
authors.affiliation: Institute of Cancer Research, Affiliated Tumor Hospital of Guangzhou Medical College, Guangzhou, China. iamcws@163.com
authors.forename: Wen-sheng
authors.initials: WS
authors.lastname: Chen
authors.forename: Lei
authors.initials: L
authors.lastname: Ma
authors.forename: Xiao-ye
authors.initials: XY
authors.lastname: Hu
authors.forename: Xiao-yan
authors.initials: XY
authors.lastname: Liu
authors.forename: Chuan
authors.initials: C
authors.lastname: Jin
authors.forename: Zhi-biao
authors.initials: ZB
authors.lastname: Li
authors.forename: Wei-dong
authors.initials: WD
authors.lastname: Li
mesh_terms: D000071916:AC133 Antigen; D000230:Adenocarcinoma / Q000378:metabolism* / Q000601:surgery; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000378:metabolism*; D003110:Colonic Neoplasms / Q000378:metabolism* / Q000601:surgery; D005260:Female; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D007120:Immunochemistry; D008297:Male; D008875:Middle Aged; D050814:Octamer Transcription Factor-3 / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism*; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D000071916:AC133 Antigen; D015703:Antigens, CD; D006023:Glycoproteins; D050814:Octamer Transcription Factor-3; C494173:POU5F1 protein, human; C000606023:PROM1 protein, human; D010455:Peptides