title: Tricomponent catalytic α,α-difluorination of acid chlorides.
abstract: The selective α,α-difluorination of carbonyl compounds remains a challenge in modern organic synthesis; current methods often incorporate stepwise processes and/or harsh conditions, providing unsatisfactory mixtures of mono- and difluorinated products. In this communication, a practical, mild, and one-pot method for the selective α,α-difluorination of readily available acid chlorides is reported in which three separate catalysts act synergistically to form products in outstanding selectivity and fair to excellent yields.
authors.affiliation: Department of Chemistry, New Chemistry Building, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Bloom
authors.forename: Michael T
authors.initials: MT
authors.lastname: Scerba
authors.forename: Jeremy
authors.initials: J
authors.lastname: Erb
authors.forename: Thomas
authors.initials: T
authors.lastname: Lectka
mesh_terms: D000143:Acids / Q000737:chemistry; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry*; D054879:Halogenation; D015394:Molecular Structure
chemical_list: D000143:Acids; D002712:Chlorides