title: 10-Gingerol, a component of rikkunshito, improves cisplatin-induced anorexia by inhibiting acylated ghrelin degradation.
abstract: Rikkunshito (RKT), a Japanese traditional medicine, has been shown to stimulate food intake in rats with cisplatin-induced anorexia; however, the underlying mechanisms remain unknown. In this study, we investigated whether RKT is involved in the degradation of peripheral ghrelin. RKT inhibited decreases in plasma ghrelin level and enhanced acyl- to desacyl-ghrelin (A/D) ratio in cisplatin-treated rats. Several components of RKT demonstrated inhibitory activity against ghrelin deacylating enzymes. In addition, 10-gingerol, a component of RKT, inhibited exogenous ghrelin deacylation. Therefore, RKT may enhance plasma acyl-ghrelin level, at least in part, by inhibiting the circulating ghrelin degrading enzyme.
authors.affiliation: Department of Pathophysiology and Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo, Hokkaido 060-0812, Japan.
authors.forename: Chiharu
authors.initials: C
authors.lastname: Sadakane
authors.forename: Shuichi
authors.initials: S
authors.lastname: Muto
authors.forename: Koji
authors.initials: K
authors.lastname: Nakagawa
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Ohnishi
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Saegusa
authors.forename: Miwa
authors.initials: M
authors.lastname: Nahata
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Hattori
authors.forename: Masahiro
authors.initials: M
authors.lastname: Asaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takeda
mesh_terms: D000215:Acylation; D000818:Animals; D000855:Anorexia / Q000139:chemically induced / Q000188:drug therapy*; D043182:Carboxylesterase / Q000037:antagonists & inhibitors; D002396:Catechols / Q000627:therapeutic use*; D002945:Cisplatin / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005233:Fatty Alcohols / Q000627:therapeutic use*; D054439:Ghrelin / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002396:Catechols; D004365:Drugs, Chinese Herbal; D005233:Fatty Alcohols; D054439:Ghrelin; C084136:liu-jun-zi-tang; C007845:gingerol; D043182:Carboxylesterase; D002945:Cisplatin