title: Pseudoangiomatous stromal hyperplasia (PASH) of the breast: a clinicopathological study of 79 cases.
abstract: BACKGROUND
  Pseudoangiomatous stromal hyperplasia (PASH) of the breast is a benign lesion that can present as a palpable nodule or as an incidental finding in breast biopsies.
  
  
  METHODS
  The study comprised 79 cases diagnosed at Loyola University Medical Center from 2002 to 2009. The pathology slides were reviewed to document the distribution, type, and association with preneoplastic or neoplastic epithelial lesions. Z-test for independent proportions is used for analysis.
  
  
  RESULTS
  A total of 76 patients were female and 3 were male. In all, 59.8% of patients presented with a breast mass and in 40.2% the lesion was an incidental finding. Classical PASH morphology was seen in 97.6% and proliferative PASH in 2.4%. Associated epithelial lesions were benign proliferative changes in 60.4%, atypical ductal and atypical lobular hyperplasia in 25.6% and infiltrating carcinoma in 11% of cases.
  
  
  CONCLUSIONS
  Based on these results, extensive sampling of biopsy specimen with PASH and appropriate clinical and radiologic follow-up is recommended.
authors.affiliation: Department of Pathology, Loyola University Medical Center, Building 110, 2160 S. First Avenue, Maywood, IL 60153, USA. edrinka@lumc.edu
authors.forename: Eva K
authors.initials: EK
authors.lastname: Drinka
authors.forename: Archana
authors.initials: A
authors.lastname: Bargaje
authors.forename: Çağatay H
authors.initials: ÇH
authors.lastname: Erşahin
authors.forename: Priya
authors.initials: P
authors.lastname: Patel
authors.forename: Alia
authors.initials: A
authors.lastname: Salhadar
authors.forename: James
authors.initials: J
authors.lastname: Sinacore
authors.forename: Prabha
authors.initials: P
authors.lastname: Rajan
mesh_terms: D000328:Adult; D000798:Angiomatosis / Q000150:complications / Q000473:pathology*; D001941:Breast Diseases / Q000150:complications / Q000473:pathology*; D002277:Carcinoma / Q000150:complications / Q000473:pathology; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000150:complications / Q000473:pathology*; D008297:Male; D012189:Retrospective Studies