title: Early stage breast cancer and radiotherapy: update.
abstract: Breast cancer (BC) is the most common malignancy among women. Therapeutic options are based on disease staging, histopathological characteristics, age, and others. The objective of the present study is to carry out an update of the concepts and definitions of radiotherapy (RT) in conservative treatment of early-stage breast cancer, with emphasis on indications, contraindications, RT dose fractionation schedules (classic, hypofractionated and partial breast irradiation), adjuvant RT in ductal carcinoma in situ (DCIS) and molecular predictors of recurrence. MEDLINE, SciELO and Cochrane databases were used for article selection. Adjuvant RT is indicated for patients with BC who underwent conservative breast surgery. In selected patients, hypofractionated or partial breast irradiation can be used. Adjuvant RT should be provided for all patients with DCIS. The correlation of RT and molecular predictors of local and systemic recurrence are not yet well-known.
authors.affiliation: Sírio-Libanês, Oncology Center, Department of Radiotherapy, São Paulo, SP, Brazil. gnmarta@uol.com.br
authors.forename: Gustavo Nader
authors.initials: GN
authors.lastname: Marta
authors.forename: Samir Abdallah
authors.initials: SA
authors.lastname: Hanna
authors.forename: Eduardo
authors.initials: E
authors.lastname: Martella
authors.forename: João Luis Fernandes da
authors.initials: JL
authors.lastname: Silva
authors.forename: Heloisa de Andrade
authors.initials: Hde A
authors.lastname: Carvalho
mesh_terms: D001943:Breast Neoplasms / Q000532:radiotherapy*; D002278:Carcinoma in Situ / Q000532:radiotherapy*; D018270:Carcinoma, Ductal, Breast / Q000532:radiotherapy*; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant / Q000379:methods; D016032:Randomized Controlled Trials as Topic