title: [76-year old patient with suspected but not confirmed "idiopathic myelofibrosis"].
abstract: A 76-year old patient was referred to our Oncology Unit due to hepatosplenomegaly, anemia, thrombocytopenia, eosinophilia, elevation of lactat dehydrogenase and leucocytosis with occurrence of myeloid and erythroid precursors in the peripheral blood. Histopathological examination of the bone marrow and molecular genetics showing a c-kit-D816V-mutation confirmed the diagnosis of systemic mastocytosis without evidence of idiopathic myelofibrosis. After starting of prednisone treatment anemia, thromocytopenia and the patient's performance status rapidly improved.
authors.affiliation: Medizinische Klinik, Evangelisches Krankenhaus, Düsseldorf.
authors.forename: C
authors.initials: C
authors.lastname: Feld
authors.forename: H
authors.initials: H
authors.lastname: Spangenberger
authors.forename: J
authors.initials: J
authors.lastname: Böhm
authors.forename: D
authors.initials: D
authors.lastname: Meuthen
authors.forename: I
authors.initials: I
authors.lastname: Meuthen
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008415:Mastocytosis / Q000175:diagnosis* / Q000188:drug therapy*; D011241:Prednisone / Q000627:therapeutic use*; D055728:Primary Myelofibrosis / Q000175:diagnosis / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D011241:Prednisone