title: [Liver fibrosis and cirrhosis--causes. Part I].
abstract: Liver fibrosis is one of the most compound pathological process occurred as the answer to risen inflammation factor. It is characterized by balance disorders between syntesis and degradation ECM (Extracellular Matrix) by myofibroblasts. This appears when activated by inflammation factor HSC cells transform in myofibroblasts. Among major causes of the chronic liver inflammation, with parenchymal cells destruction and replace of connective tissue, are: hepatotropic viruses (HCV, HBV), alcohol, autoimmunologic disorders.
authors.affiliation: Klinika Immunologii Transplantologii i Chorób Wewnetrznych, Instytutu Transplantologii, Warszawskiego Uniwersytetu Medycznego. awirkowska@wum.edu.pl
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Wirkowska
authors.forename: Leszek
authors.initials: L
authors.lastname: Paczek
mesh_terms: D005109:Extracellular Matrix / Q000378:metabolism / Q000473:pathology; D006505:Hepatitis / Q000150:complications* / Q000378:metabolism; D006801:Humans; D008103:Liver Cirrhosis / Q000209:etiology* / Q000378:metabolism