title: [Surgical outcomes for 187 patients with locally recurrent rectal cancer and analysis of prognostic factors].
abstract: OBJECTIVE
  To evaluate the surgical outcomes for patients with locally recurrent rectal cancer (LRRC) and to analyze the prognostic factors.
  
  
  METHODS
  Clinical data of 187 patients with LRRC undergoing surgery at the First Hospital of peking University from January 1985 to December 2009 were retrospectively reviewed.
  
  
  RESULTS
  Procedures performed included local resection(n=34), abdominoperineal resection (n=35), posterior pelvic exenteration (n=17), total pelvic exenteration(TPE, n=98), TPE with sacrectomy (n=2), and TPE with internal hemipelvectomy (n=1). The operation was R0 in 87 patients, R1 in 60, and R2 in 40. The degree of radical resection was associated with the initial surgery and the degree of pelvic fixation (P<0.05). The pelvic recurrence rate was 44.4%(64/144). The operative morbidity and mortality were 47.5%(89/187) and 2.7%(5/187), respectively. The overall 3- and 5-year survival rates were 42.2% and 30.7%, respectively. The degree of radical resection and lymph node metastasis were independent risk factors associated with prognosis. The 5-year survival rates of R0, R1 and R2 were 42.6%, 17.2% and 0, respectively(P<0.01). The 5-year survival rates of patients with and without lymph node metastasis were 5.6% and 40.5%(P<0.01) respectively.
  
  
  CONCLUSIONS
  Accurate evaluation of extent of pelvic fixation and achievement of R0 resection are critical to improve the surgical outcomes for LRRC.
authors.affiliation: Department of General Surgery, The First Hospital, Peking University, Beijing 100034, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Jiang
authors.forename: Yuan-lian
authors.initials: YL
authors.lastname: Wan
authors.forename: Yu-cun
authors.initials: YC
authors.lastname: Liu
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Yi-sheng
authors.initials: YS
authors.lastname: Pan
authors.forename: Tao
authors.initials: T
authors.lastname: Wu
authors.forename: Peng-yuan
authors.initials: PY
authors.lastname: Wang
authors.forename: Shan-jun
authors.initials: SJ
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D010385:Pelvic Exenteration / Q000379:methods; D011379:Prognosis; D012004:Rectal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D012189:Retrospective Studies; D015996:Survival Rate