title: [Influence of maternal and neonatal factors on bronchopulmonary dysplasia development].
abstract: OBJECTIVE
  To review epidemiological features of bronchopulmonary dysplasia (BPD) and its relationship with maternal and neonatal conditions in a neonatal unit.
  
  
  METHODS
  Cross-sectional, descriptive and analytical study involving preterm newborns (NBs) with a birth weight lower than 1,500 g and gestational age under 37 weeks. Data was collected through a review of medical records of these newborns admitted to a neonatal unit.
  
  
  RESULTS
  The study included 323 newborns with a mean birth weight of 1,161 g (± 231 g), gestational age between 24 and 36.5 weeks, with a BPD incidence of 17.6%. Among the NBs developing BPD, the mean of days using invasive mechanical ventilation (IMV), non-invasive ventilation (NIMV), and supplemental oxygen was 17.6, 16.2, and 46.1 days, respectively, with a time significantly longer for those NBs developing BPD (p < 0.001). BPD occurred significantly more often in NBs with a patent ductus arteriosus (PDA).
  
  
  CONCLUSIONS
  BPD incidence in this study was similar to that found in the literature. No BPD association with maternal infection and antenatal corticosteroid use was found. NBs receiving exogenous surfactant had a higher BPD incidence because they had lower BW and GA. Concomitant occurrence of PDA and BPD is associated with staying longer on IMV, NIMV and supplemental oxygen.
authors.affiliation: Instituto de Medicina Integral Prof. Fernando Figueira – IMIP, Recife, PE, Brazil.
authors.forename: Marcela Raquel de Oliveira
authors.initials: MR
authors.lastname: Lima
authors.forename: Maria do Amparo
authors.initials: Mdo A
authors.lastname: Andrade
authors.forename: Ana Paula Guimarães de
authors.initials: AP
authors.lastname: Araújo
authors.forename: José Natal
authors.initials: JN
authors.lastname: Figueroa
authors.forename: Lívia Barboza de
authors.initials: LB
authors.lastname: Andrade
mesh_terms: D001724:Birth Weight / Q000502:physiology*; D001938:Brazil / Q000453:epidemiology; D001997:Bronchopulmonary Dysplasia / Q000453:epidemiology* / Q000209:etiology; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D004374:Ductus Arteriosus, Patent / Q000150:complications; D005260:Female; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D008297:Male; D011663:Pulmonary Surfactants / Q000009:adverse effects; D012121:Respiration, Artificial; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors
chemical_list: D011663:Pulmonary Surfactants