title: [Metabolic abnormalities in polycystic ovary syndrome women: obese and non obese].
abstract: OBJECTIVE
  To compare the metabolic characteristics of obese and non-obese young women with polycystic ovary syndrome (POS) from the Brazilian Southeast.
  
  
  METHODS
  This was a cross-sectional study conducted on 218 women of reproductive age with a diagnosis of POS--90 non-obese women (BMI between 18.5 and 29.9 kg/m²), and 128 obese patients (BMI > 30 kg/m²) selected at the time of diagnosis. The frequency of insulin resistance (IR), glucose intolerance (GI), metabolic syndrome (MetS) and type 2 diabetes mellitus (DM2) and mean values of total cholesterol (TC), triglycerides (TG), high-density (HDL) and low-density lipoproteins (LDL), were compared between obese and non-obese patients with POS. The two groups were also compared in terms of clinical and hormonal characteristics (follicle stimulating hormone, prolactin, thyroid stimulating hormone, total testosterone, dihydroepiandrostenedione sulfate, and 17-hydroxyprogesterone). Statistical analysis was performed using the SAS 9.0 software. Quantitative variables were compared by the Student's t-test (data with normal distribution) or by the Mann-Whitney test (non-parametric distribution). Qualitative variables were compared by the Fisher test. The level of significance was set at 5% (p < 0.05) in all analyses.
  
  
  RESULTS
  The frequency of IR, GI and MetS was significantly higher in obese than non-obese patients with POS (66.7, 29.9, and 63% versus 24.7, 12.2, and 16.4%, respectively). Obese patients had higher TC and TG levels (189.8 ± 35.8 mg/dL and 145.4 ± 71.1 mg/dL, respectively) than non-obese patients (172.1 ± 38.4 mg/dL and 99.3 ± 54 mg/dL, respectively). Both groups had mean HDL levels below 50 mg/dL.
  
  
  CONCLUSIONS
  Young obese women with POS have a higher frequency of IR, GI and MS than non-obese. However, the occurrence of metabolic disorders is elevated also in the non-obese patients, suggesting that the presence of the syndrome may favor the development of metabolic comorbidities with potential medium- and long-term repercussions.
authors.affiliation: Departamento de Neurociências e Ciências do Comportamento do Hospital das Clínicas de Ribeirão Preto, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo-FMRP-USP- Ribeirão Preto (SP), Brasil.
authors.forename: Lucas Gabriel Maltoni
authors.initials: LG
authors.lastname: Romano
authors.forename: Giuliano
authors.initials: G
authors.lastname: Bedoschi
authors.forename: Anderson Sanches
authors.initials: AS
authors.lastname: Melo
authors.forename: Felipe Oliveira de
authors.initials: FO
authors.lastname: Albuquerque
authors.forename: Ana Carolina Japur de Sá
authors.initials: AC
authors.lastname: Rosa e Silva
authors.forename: Rui Alberto
authors.initials: RA
authors.lastname: Ferriani
authors.forename: Paula Andrea
authors.initials: PA
authors.lastname: Navarro
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D009765:Obesity / Q000150:complications*; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000378:metabolism*; D055815:Young Adult