title: [Metformin--an inhibitor of early stages of protein glycation].
abstract: Nonenzymatic glycation of proteins is associated with the long-term diabetes complication. The aim of this work was to examine in vitro the infuence of metformin on glycated proteins formation by mass spectrometry (ESI/MS, LC/MS/MS) and spectrofluorimetric method. Obtained results suggest that metformin dose-dependently inhibits early stage of Maillard reaction, although with the weaker potency than known glycation inhibitor aminoguanidine.
authors.affiliation: Katedra Farmakologii, Collegium Medicum Uniwersytetu Jagiellońskiego, Kraków. bebujak@gmail.com
authors.forename: Beata
authors.initials: B
authors.lastname: Bujak-Gizycka
authors.forename: Maciej
authors.initials: M
authors.lastname: Suski
authors.forename: Rafał
authors.initials: R
authors.lastname: Olszanecki
authors.forename: Józef
authors.initials: J
authors.lastname: Madej
authors.forename: Ryszard
authors.initials: R
authors.lastname: Korbut
mesh_terms: D002853:Chromatography, Liquid / Q000379:methods; D003920:Diabetes Mellitus / Q000188:drug therapy; D004044:Dietary Proteins / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006031:Glycosylation / Q000187:drug effects; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D015416:Maillard Reaction / Q000187:drug effects*; D013058:Mass Spectrometry / Q000379:methods; D008687:Metformin / Q000494:pharmacology*; D009211:Myoglobin / Q000187:drug effects; D012709:Serum Albumin / Q000187:drug effects*
chemical_list: D004044:Dietary Proteins; D017127:Glycation End Products, Advanced; D007004:Hypoglycemic Agents; D009211:Myoglobin; D012709:Serum Albumin; D008687:Metformin