title: [IBD ahead 2010--Answering important questions in Crohn's disease treatment].
abstract: The treatment of patients with inflammatory bowel disease has become more complex in recent years through the introduction of various immunosuppressive agents as well as the approval of monoclonal antibodies against TNF-α and patients receiving such treatment must be carefully monitored. National and international guidelines define a diagnostic and therapeutic context for the practitioner, but can only partially respond to specific questions on the procedure for individual patients. Within the framework of a project initiated by Abbott entitled "IBD ahead" 38 German IBD experts have elaborated concrete proposals for dealing with corticosteroids, immunosuppressants and TNF-α antibodies on the basis of the published literature and their own personal experience in order to close the gap between these guidelines and daily clinical practice. Statements were developed on the choice of correct timing of initiation, dose and duration of the individual substances and on how to proceed with patients exhibiting treatment failure. Moreover, recommendations are also made on drug combination strategies, safety monitoring and the risks regarding the development of infectious complications and malignancies. These recommendations are illustrated by case studies from everyday practice in participating centres.
authors.affiliation: Universitätklinikum Jena, Klinik für Innere Medizin II, Abteilung für Gastroenterologie, Hepatologie und Infektiologie.
authors.forename: C
authors.initials: C
authors.lastname: Schmidt
authors.forename: A
authors.initials: A
authors.lastname: Dignass
authors.forename: F
authors.initials: F
authors.lastname: Hartmann
authors.forename: D
authors.initials: D
authors.lastname: Hüppe
authors.forename: W
authors.initials: W
authors.lastname: Kruis
authors.forename: P
authors.initials: P
authors.lastname: Layer
authors.forename: A
authors.initials: A
authors.lastname: Lüers
authors.forename: A
authors.initials: A
authors.lastname: Stallmach
authors.forename: N
authors.initials: N
authors.lastname: Teich
authors.forename: A
authors.initials: A
authors.lastname: Sturm
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000627:therapeutic use; D003424:Crohn Disease / Q000150:complications / Q000276:immunology / Q000628:therapy*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005765:Gastrointestinal Agents / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D043183:Irritable Bowel Syndrome / Q000139:chemically induced / Q000188:drug therapy; D017211:Treatment Failure; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
chemical_list: D000305:Adrenal Cortex Hormones; D000911:Antibodies, Monoclonal; D005765:Gastrointestinal Agents; D007166:Immunosuppressive Agents; D014409:Tumor Necrosis Factor-alpha