title: Flavone C-glycosides from the leaves of Lophatherum gracile and their in vitro antiviral activity.
abstract: Four new flavone C-glycosides, luteolin 6-C-α-L-arabinopyranosyl-7-O-β-D-glucopyranoside, apigenin 6-C-β-D-galactopyranosiduronic acid (1 → 2)-α-L-arabinopyranoside, luteolin 6-C-β-D-galactopyranosiduronic acid (1 → 2)-α-L-arabinopyranoside, and luteolin 6-C-β-D-glucopyranosiduronic acid (1 → 2)-α-L-arabinofuranoside, along with three known ones, were isolated from the leaves of Lophatherum gracile. The structures of the new compounds were elucidated by extensive spectroscopic methods as well as acid hydrolysis. All the flavone glycosides isolated from this plant were screened for their in vitro antiviral activity against respiratory syncytial virus (RSV) with cytopathic effect (CPE) reduction assay, and several flavone 6-C-monoglycosides showed potent in vitro anti-RSV effect.
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Mei
authors.initials: M
authors.lastname: Chen
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Zhang
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Huang
authors.forename: Xin
authors.initials: X
authors.lastname: Wu
authors.forename: Qing-Wen
authors.initials: QW
authors.lastname: Zhang
authors.forename: Yao-Lan
authors.initials: YL
authors.lastname: Li
authors.forename: Wen-Cai
authors.initials: WC
authors.lastname: Ye
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves; D006109:Poaceae / Q000737:chemistry*; D012136:Respiratory Syncytial Viruses / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D006027:Glycosides; D010936:Plant Extracts