title: Immune-mediated thrombocytopenia associated with angiostrongylus vasorum infection in a Jack Russell terrier.
abstract: A twenty-month-old Jack Russell terrier was presented with a four-day history of thrombocytopenia, echymotic inguinal haemorrhages, coughing and reduced exercise tolerance. Clinical examination revealed several petechial haemorrhages on the gingivae and small echymotic haemorrhages in the inguinal region, along with mild bilateral epistaxis. Haematology confirmed a platelet count of 1.0 × 10/L. Thoracic radiographs revealed a wide-spread mixed alveolar-interstitial lung pattern, apparent throughout the entire lungfield, but particularly marked within the left lung lobes. A presumptive diagnosis of immune-mediated thrombocytopenia was made and the dog was treated with vincristine and immunosuppressive doses of prednisolone. Initially anaemia developed following gastrointestinal haemorrhage; however, after symptomatic treatment the dog showed a marked clinical improvement. Evaluation for an underlying cause of the disease revealed Angiostrongylus vasorum L1 larvae on faecal analysis and treatment with fenbendazole was commenced. The dog made a full clinical recovery with all treatment was withdrawn within five weeks of diagnosis. This is the second report of immune-mediated thrombocytopenia associated with Angiostrongylus vasorum infection and it is the first to be successfully managed. The report highlights that Angiostrongylus vasorum should be considered in young dogs presented with thrombocytopenia.
authors.affiliation: School of Agriculture, Food Sciences and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland. emma.oneill@ucd.ie.
authors.forename: Emma
authors.initials: E
authors.lastname: Jo'neill
authors.forename: Els
authors.initials: E
authors.lastname: Acke
authors.forename: Emma
authors.initials: E
authors.lastname: Tobin
authors.forename: Grainne
authors.initials: G
authors.lastname: McCarthy