title: Continuous renal replacement therapy with Prismaflex HF20 disposable set in children from 4 to 15 kg.
abstract: Continuous venovenous hemodiafiltration (CVVHDF) in infants is challenging due to a lack of specific and widely available technology. There is need for high precision of fluid balance and hemodynamic stability. The aim of this study is to report the first experience with the newly developed Prismaflex HF20 disposable set (HF20 set) in infants with CVVHDF. We provided safe treatment in four infants (4-14 kg) suffering from acute renal failure with the HF20 set. Treatment monitoring included patients' blood pressure, patients' weight change, and fluid balance. The anticoagulation was performed with unfractionated heparin. We used commercially available bicarbonate-buffered solutions as dialysate fluid and substitution fluid. At start and during the treatment, the patients showed hemodynamic stability. Desired fluid balance was achieved in all patients during the treatment periods of 49-102 hours. No complications occurred. This report presents CVVHDF experience on the feasibility and safety of the HF20 set in infants. It can be used in CVVHDF or hemodialysis mode. Treatments were well tolerated in all patients, and flow rate adaptability to infants' needs was very acceptable, and the usage of this device was easy and safe.
authors.affiliation: Department of Paediatrics, Pediatric Intensive Care Unit, Medical University of Graz, Graz, Austria. siegfried.roedl@medunigraz.at
authors.forename: Siegfried
authors.initials: S
authors.lastname: Rödl
authors.forename: Ingrid
authors.initials: I
authors.lastname: Marschitz
authors.forename: Christoph J
authors.initials: CJ
authors.lastname: Mache
authors.forename: Martin
authors.initials: M
authors.lastname: Koestenberger
authors.forename: Georg
authors.initials: G
authors.lastname: Madler
authors.forename: Gerfried
authors.initials: G
authors.lastname: Zobel
mesh_terms: D058186:Acute Kidney Injury / Q000628:therapy*; D000925:Anticoagulants / Q000627:therapeutic use; D001794:Blood Pressure; D001835:Body Weight; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D015314:Dialysis Solutions / Q000737:chemistry*; D017583:Hemodiafiltration / Q000295:instrumentation*; D006439:Hemodynamics; D006493:Heparin / Q000737:chemistry; D006801:Humans; D007223:Infant; D006435:Renal Dialysis / Q000379:methods*; D017582:Renal Replacement Therapy / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D015314:Dialysis Solutions; D006493:Heparin; D003404:Creatinine