title: Striatal volumes in pediatric bipolar patients with and without comorbid ADHD.
abstract: The most prevalent comorbid disorder in pediatric bipolar disorder (BD) is attention-deficit/hyperactivity disorder (ADHD). As caudate volume abnormalities have been demonstrated in both BD and ADHD, this study sought to determine whether these findings could be attributed to separable effects from either diagnosis. High resolution anatomical magnetic resonance (MRI) images were obtained from youth in 4 groups: BD with comorbid ADHD (n=17), BD without comorbid ADHD (n=12), youth with ADHD alone (n=11), and healthy control subjects (n=24). Caudate, putamen, and globus pallidus volumes were manually traced for each subject using BrainImageJava software by a reliable rater blinded to diagnosis. There was a significant effect of diagnosis on striatal volumes, with ADHD associated with decreased caudate and putamen volumes, and BD associated with increased caudate, putamen, and globus pallidus volumes. Thus, the presence or absence of comorbid ADHD in patients with BD was associated with distinct alterations in caudate volumes, suggesting that these groups have different, but related, mechanisms of neuropathology.
authors.affiliation: Washington University School of Medicine, Saint Louis, MO, USA.
authors.forename: Isabelle Yisha
authors.initials: IY
authors.lastname: Liu
authors.forename: Meghan
authors.initials: M
authors.lastname: Howe
authors.forename: Amy
authors.initials: A
authors.lastname: Garrett
authors.forename: Asya
authors.initials: A
authors.lastname: Karchemskiy
authors.forename: Ryan
authors.initials: R
authors.lastname: Kelley
authors.forename: Dylan
authors.initials: D
authors.lastname: Alegria
authors.forename: Allan
authors.initials: A
authors.lastname: Reiss
authors.forename: Kiki
authors.initials: K
authors.lastname: Chang
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D001289:Attention Deficit Disorder with Hyperactivity / Q000453:epidemiology / Q000473:pathology*; D001714:Bipolar Disorder / Q000453:epidemiology / Q000473:pathology*; D001931:Brain Mapping; D002648:Child; D015897:Comorbidity; D003342:Corpus Striatum / Q000473:pathology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D012044:Regression Analysis