title: The expression and function of miRNA-451 in non-small cell lung cancer.
abstract: miRNAs are small, non-coding RNAs that negatively regulate gene expression at the post-transcriptional and translational levels. miRNA-451 was previously reported to be down-regulated in gastric and colorectal cancers. Here, we showed that miRNA-451 expression decreased in non-small cell lung cancer (NSCLC) tissues and that its expression was negatively associated with lymph node metastasis, the stage of TNM classification and poor prognosis of NSCLC patients. Moreover, significantly different miRNA-451 expression levels were found between smoking and non-smoking patients. The overexpression of miRNA-451 inhibited cell cycle progression, cellular migration and the invasive ability of NSCLC cells. Increased miRNA-451 expression also promoted anoikis of NSCLC cells. Together, these data suggested that aberrantly expressed miRNA-451 may be associated with the development of NSCLC.
authors.affiliation: Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science, Tianjin, China. wxc3188@126.com
authors.forename: Xiao-chun
authors.initials: XC
authors.lastname: Wang
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Tian
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Jiang
authors.forename: Yue-Ying
authors.initials: YY
authors.lastname: Wang
authors.forename: De-Guan
authors.initials: DG
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: She
authors.forename: Jian-Hui
authors.initials: JH
authors.lastname: Chang
authors.forename: Ai-Min
authors.initials: AM
authors.lastname: Meng
mesh_terms: D023102:Anoikis; D015152:Blotting, Northern; D015153:Blotting, Western; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D002469:Cell Separation; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000235:genetics / Q000473:pathology; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000235:genetics / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012907:Smoking / Q000009:adverse effects / Q000235:genetics
chemical_list: D035683:MicroRNAs