title: Insulin-like growth factor I - a novel biomarker of abdominal aortic aneurysms.
abstract: OBJECTIVE
  The study aimed to test the potential role of insulin-like growth factor I (IGF-I) and IGF-II as biomarkers for abdominal aortic aneurysm (AAA).
  
  
  RESULTS
  IGF-I and II levels were analysed in 115 patients with screening diagnosed AAA kept under annual surveillance for 10 years. Serum IGF-I correlated positively with AAA size and growth rate (r = 0.23, P = 0.016 and r = 0.27, P = 0.004), persisting after adjustment for potential confounders. Serum IGF-I level predicted cases needing later surgery (AOC: 0.63; 95% confidence interval: 0.52-0.73).
  
  
  CONCLUSIONS
  In this prospective, long-term study, baseline serum IGF-I correlated positively with AAA size and growth rate and predicted future need for preventive surgery.
authors.affiliation: Vascular Research Unit, Department of Vascular Surgery, Viborg Hospital, Viborg, Denmark. jes.s.lindholt@viborg.rm.dk
authors.forename: J S
authors.initials: JS
authors.lastname: Lindholt
authors.forename: J L
authors.initials: JL
authors.lastname: Martin-Ventura
authors.forename: S
authors.initials: S
authors.lastname: Urbonavicius
authors.forename: P
authors.initials: P
authors.lastname: Ramos-Mozo
authors.forename: A
authors.initials: A
authors.lastname: Flyvbjerg
authors.forename: J
authors.initials: J
authors.lastname: Egido
authors.forename: E W
authors.initials: EW
authors.lastname: Henneberg
authors.forename: J
authors.initials: J
authors.lastname: Frystyk
mesh_terms: D017544:Aortic Aneurysm, Abdominal / Q000097:blood* / Q000175:diagnosis* / Q000628:therapy; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D011159:Population Surveillance; D011237:Predictive Value of Tests
chemical_list: D015415:Biomarkers; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II