title: Continuous-flow, palladium-catalysed alkoxycarbonylation reactions using a prototype reactor in which it is possible to load gas and heat simultaneously.
abstract: A prototype tube-in-tube reactor in which it is possible to load gas and heat simultaneously has been used in a continuous-flow approach to alkoxycarbonylation reactions of aryl iodides. In the stainless steel coil, liquid flows on the outside of a gas-permeable membrane. The coil can be heated and the temperature can be measured accurately via a probe touching the outer steel surface. A range of aryl iodides can be transformed to the corresponding esters in excellent conversion by reaction at 120 °C using 0.5 mol% palladium acetate as the catalyst with no additional ligand required. Small-scale optimization and substrate screening runs were followed by scale-up.
authors.affiliation: Department of Chemistry, University of Connecticut, 55 North Eagleville Rd, Storrs, CT 06269-3060, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Mercadante
authors.forename: Nicholas E
authors.initials: NE
authors.lastname: Leadbeater
mesh_terms: D002384:Catalysis; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry; D005740:Gases / Q000737:chemistry*; D006358:Hot Temperature; D006847:Hydrocarbons, Iodinated / Q000737:chemistry; D046210:Microfluidic Analytical Techniques; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D013499:Surface Properties; D013696:Temperature
chemical_list: D004952:Esters; D005740:Gases; D006847:Hydrocarbons, Iodinated; D009942:Organometallic Compounds; D010165:Palladium