title: Synthesis of novel β-aminocyclobutanecarboxylic acid derivatives by a solvent-free aza-Michael addition and subsequent ring closure.
abstract: Novel β-aminocyclobutanecarboxylic acid derivatives were prepared via a sequential solvent-free aza-Michael addition of benzophenone imine across 3-halopropylidenemalonates and base-induced ring closure. These highly substituted cyclobutanedicarboxylic acid derivatives were subjected to a reactivity study which demonstrated the tendency of these donor-acceptor substituted four-membered rings to be converted into their corresponding ring-opened products.
authors.affiliation: Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure links 653, B-9000 Ghent, Belgium.
authors.forename: Tamara
authors.initials: T
authors.lastname: Meiresonne
authors.forename: Sven
authors.initials: S
authors.lastname: Mangelinckx
authors.forename: Norbert
authors.initials: N
authors.lastname: De Kimpe
mesh_terms: D001372:Aza Compounds / Q000737:chemistry*; D002264:Carboxylic Acids / Q000138:chemical synthesis*; D003503:Cyclobutanes / Q000138:chemical synthesis*; D015394:Molecular Structure
chemical_list: C542744:2-aminocyclobutanecarboxylic acid; D001372:Aza Compounds; D002264:Carboxylic Acids; D003503:Cyclobutanes