title: [Incidence of lip and palate clefts in children in Nis from 1990 to 2007].
abstract: BACKGROUND
  Cleft lip and palate is a complex congenital anomaly of the orofacial system in children.
  
  
  OBJECTIVE
  The aim of this study was to determine the incidence of live-born children with cleft lip and/or palate compared to the total number of children born in the period from January 1, 1990 to December 31, 2007.
  
  
  METHODS
  Epidemiological investigation was based on the records of live-born children at the Hospital of Gynaecology and Obstetrics of the Clinical Centre Nis. The study included 61,116 live-born children, i.e. 56,905 full-term babies.
  
  
  RESULTS
  The total number of registered clefts during the investigation period was 43 (22 boys and 21 girls). The most frequent were the secondary palate clefts (44.2%); combined cleft were present in 34.9%, while primary palate clefts were reported in 20.9%. In respect to the season and order of birth, there was no statistically significant difference in the frequency of the primary, secondary and complete palate clefts. The age of mothers was not identified as a risk factor for the occurrence of cleft lip and palate.
  
  
  CONCLUSIONS
  In the studied period, 43 children were born with the cleft lip and/or palate, equally in boys as in girls. The secondary palate clefts were most frequent. The season and order of birth had no statistical influence on the occurrence of this anomaly.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Mitić
authors.forename: Marina
authors.initials: M
authors.lastname: Jonović
authors.forename: Nadica
authors.initials: N
authors.lastname: Mitić
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Mitić
authors.forename: Dejan
authors.initials: D
authors.lastname: Mitić
authors.forename: Mariola
authors.initials: M
authors.lastname: Stojanović
authors.forename: Predrag
authors.initials: P
authors.lastname: Kovačević
mesh_terms: D000328:Adult; D001722:Birth Order; D002971:Cleft Lip / Q000150:complications / Q000453:epidemiology* / Q000473:pathology; D002972:Cleft Palate / Q000150:complications / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D008297:Male; D008423:Maternal Age; D055771:Serbia / Q000453:epidemiology