title: Novel roles for hERG K(+) channels in cell proliferation and apoptosis.
abstract: The human ether-a-go-go-related gene potassium channel (hERG, Kv11.1, KCNH2) has an essential role in cardiac action potential repolarization. Electrical dysfunction of the voltage-sensitive ion channel is associated with potentially lethal ventricular arrhythmias in humans. hERG K(+) channels are also expressed in a variety of cancer cells where they control cell proliferation and apoptosis. In this review, we discuss molecular mechanisms of hERG-associated cell cycle regulation and cell death. In addition, the significance of hERG K(+) channels as future drug target in anticancer therapy is highlighted.
authors.affiliation: Department of Cardiology, Medical University Hospital, Heidelberg, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Jehle
authors.forename: P A
authors.initials: PA
authors.lastname: Schweizer
authors.forename: H A
authors.initials: HA
authors.lastname: Katus
authors.forename: D
authors.initials: D
authors.lastname: Thomas
mesh_terms: D017209:Apoptosis; D049109:Cell Proliferation / Q000187:drug effects; D051638:Ether-A-Go-Go Potassium Channels / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism; D026902:Potassium Channel Blockers / Q000494:pharmacology
chemical_list: D051638:Ether-A-Go-Go Potassium Channels; D026902:Potassium Channel Blockers