title: [FABP2 gene polymorphism and metabolic disorder of lipids in the middle aged and aged population].
abstract: OBJECTIVE
  To learn the gene distribution of fatty acid binding protein gene (FABP2) and the mutation frequency of wild type A54T in FABP2 gene in the people with abnormal lipid metabolism to detect from molecular level the relationship between FABP2 gene polymorphism and metabolic disorder of lipids, and to investigate genetic factors and the pathogenesis of lipid metabolic disorders in the middle aged and aged people.
  
  
  METHODS
  The polymorphism of FABP2 gene was analyzed by RELP (Restriction fragment length polymorphism) technique. The relationship between FABP2 polymorphism and the risk of dyslipidemia in 410 middle aged and aged people was investigated.
  
  
  RESULTS
  Mutation frequency of FABP2 gene in the people with dyslipidemia was 71.9%, significantly higher than that in the people with normal blood lipids (P < 0.05). Compared with individuals with wild type homozygote (Ala54/Ala54), the serum TC and TG of individuals with mutational heterozygote (Ala54/Thr54) or mutational homozygote (Thr54/Thr54) were distinctly higher, and serum HDL-C of them were distinctly lower (P < 0.05).
  
  
  CONCLUSIONS
  FABP2 gene polymorphism might be one of factors for genetic susceptibility in metabolic disorder of lipids. The risk of occurring lipid metabolic disorders in individuals carrying mutational FABP2 gene (Ala54/Thr54, Thr54/Thr54) might be higher than those carrying wild type homozygote (Ala54/ Ala54) while exposed to the same environment.
authors.affiliation: School of Public Health, Southeast University, Nanjing 210009, China. liuyaqi7@gmail.com
authors.forename: Yaqi
authors.initials: Y
authors.lastname: Liu
authors.forename: Chengkai
authors.initials: C
authors.lastname: Zhai
authors.forename: Pei
authors.initials: P
authors.lastname: Cao
authors.forename: Yanze
authors.initials: Y
authors.lastname: Zheng
authors.forename: Siyu
authors.initials: S
authors.lastname: Zhou
authors.forename: Jing
authors.initials: J
authors.lastname: Chi
mesh_terms: D000368:Aged; D050171:Dyslipidemias / Q000235:genetics* / Q000503:physiopathology; D050556:Fatty Acid-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011110:Polymorphism, Genetic
chemical_list: C493404:FABP2 protein, human; D050556:Fatty Acid-Binding Proteins