title: Intestinal stem cells in the adult Drosophila midgut.
abstract: Drosophila has long been an excellent model organism for studying stem cell biology. Notably, studies of Drosophila's germline stem cells have been instrumental in developing the stem cell niche concept. The recent discovery of somatic stem cells in adult Drosophila, particularly the intestinal stem cells (ISCs) of the midgut, has established Drosophila as an exciting model to study stem cell-mediated adult tissue homeostasis and regeneration. Here, we review the major signaling pathways that regulate the self-renewal, proliferation and differentiation of Drosophila ISCs, discussing how this regulation maintains midgut homeostasis and mediates regeneration of the intestinal epithelium after injury.
authors.affiliation: Department of Developmental Biology, UT Southwestern Medical Center, 6000 Harry Hines Blvd., Dallas, TX 75235, USA. Huaqi.Jiang@UTSouthwestern.edu
authors.forename: Huaqi
authors.initials: H
authors.lastname: Jiang
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Edgar
mesh_terms: D053687:Adult Stem Cells / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D004330:Drosophila / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D006706:Homeostasis / Q000235:genetics / Q000502:physiology; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000166:cytology* / Q000502:physiology; D008954:Models, Biological; D051880:Receptors, Notch / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D012038:Regeneration / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D051153:Wnt Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology
chemical_list: D051880:Receptors, Notch; D051153:Wnt Proteins