title: Bioactive A-type proanthocyanidins from Cinnamomum cassia.
abstract: Two trimeric proanthocyanidins, cinnamtannin B-1 (1) and cinnamtannin D-1 (2), have been isolated from the bark of Cinnamomum cassia along with the known tetramer parameritannin A-1 (3) and a previously unreported tetramer, named cassiatannin A (4). The structures of 1-4 were elucidated on the basis of 1D and 2D NMR, MS, and CD analyses and compared to the reported data. Proanthocyanidins (1-4) possess significant in vitro inhibitory activity against cyclooxygenase-2 (COX-2) at micromolar concentrations.
authors.affiliation: Bruker Biospin Corporation, Billerica, Massachusetts 01821, United States.
authors.forename: K Brian
authors.initials: KB
authors.lastname: Killday
authors.forename: Matthew H
authors.initials: MH
authors.lastname: Davey
authors.forename: Jan A
authors.initials: JA
authors.lastname: Glinski
authors.forename: Penggao
authors.initials: P
authors.lastname: Duan
authors.forename: Ravikanth
authors.initials: R
authors.lastname: Veluri
authors.forename: Gloria
authors.initials: G
authors.lastname: Proni
authors.forename: F Joseph
authors.initials: FJ
authors.lastname: Daugherty
authors.forename: Michael S
authors.initials: MS
authors.lastname: Tempesta
mesh_terms: D032904:Cinnamomum aromaticum / Q000737:chemistry*; D052246:Cyclooxygenase 2 Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D044945:Proanthocyanidins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D044945:Proanthocyanidins; C517872:cinnamtannin B-1