title: Correlations of trace element levels in the diet, blood, urine, and feces in the Chinese male.
abstract: In order to explore the associations between trace elements in dietary intake and the other three biological media (blood, urine, or feces) and inter-element interactions among the latter, we simultaneously collected 72-h diet duplicates, whole blood, and 72-h urine and feces from 120 free-living healthy males in China. Correlations among the toxic (cadmium [Cd], lead [Pb]), and nutritionally essential (zinc [Zn], copper [Cu], iron [Fe], manganese [Mn], selenium [Se], iodine [I]) elements were evaluated using Spearman rank correlation analysis based on analytical data determined by inductively coupled plasma-mass spectrometry. Dietary Cd intakes were highly correlated with the fecal Cd and blood Cd levels. Inverse correlations were found for Fe-Cd and Fe-Pb in both diet versus blood and diet versus feces. Cd-Zn and Cd-Se were significantly directly correlated in the urine and feces. Cd-Se and Pb-Se were negatively correlated in blood. In addition, there existed an extremely significant association between urinary Se and urinary I. Moreover, the other two highly direct correlations were found for Se-Fe and for I-Fe in urine. Improved knowledge regarding their mutual associations is considered to be of fundamental importance to understand more the complex interrelationships in trace element metabolism.
authors.affiliation: School of Public Health, Peking University, Beijing 100191, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Yang-Li
authors.initials: YL
authors.lastname: Ou
authors.forename: Ya-Qiong
authors.initials: YQ
authors.lastname: Liu
authors.forename: Qing
authors.initials: Q
authors.lastname: Xie
authors.forename: Qing-Fen
authors.initials: QF
authors.lastname: Liu
authors.forename: Quan
authors.initials: Q
authors.lastname: Wu
authors.forename: Ti-Qiang
authors.initials: TQ
authors.lastname: Fan
authors.forename: Lai-Lai
authors.initials: LL
authors.lastname: Yan
authors.forename: Jing-Yu
authors.initials: JY
authors.lastname: Wang
mesh_terms: D000328:Adult; D044466:Asian People; D002681:China; D004435:Eating; D005243:Feces; D005504:Food Analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014131:Trace Elements / Q000008:administration & dosage / Q000032:analysis / Q000097:blood / Q000652:urine
chemical_list: D014131:Trace Elements