title: [The Israeli recommendations for diagnosis, management, follow-up and prevention of colorectal cancer (CRC) in familial adenomatous polyposis].
abstract: Approximately 30% of colorectal cancers exhibit familial clustering. We recognize different types of polyps and polyposis syndromes that are classified according to the histological diagnosis. We differentiate between adenomas, hyperplastic, and hamartomatous polyps as well as between syndromes that are manifested by 10-100 or above 100 polyps. Only about 1% of colorectaL cancers (CRCs) are due to adenomatous polyposis syndrome. It is essential to distinguish between these syndromes as each has a different mode of presentation, spectrum of signs and symptoms and cancer risk. With the knowledge that is accumulating we now have the tools to lower the risk of cancer by performing specific screening programs that are tailored to each syndrome specifically. We present the Israeli guidelines for management of adenomatous polyposis, based on the American and European experience and consensus. We outline the importance of mutti-sectorial team work that includes the family practitioner, gastroenterologist, pathologist, genetic counselor, surgeon and social worker.
authors.affiliation: The Section of Gastrointestinal Oncology, the Israeli Gastroenterology Association.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Half
authors.forename: Yael
authors.initials: Y
authors.lastname: Goldberg
authors.forename: Revital
authors.initials: R
authors.lastname: Kariv
authors.forename: Alex
authors.initials: A
authors.lastname: Vilkin
authors.forename: Zohar
authors.initials: Z
authors.lastname: Levi
authors.forename: Menachem
authors.initials: M
authors.lastname: Moshkowitz
authors.forename: Yaron
authors.initials: Y
authors.lastname: Niv
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D003111:Colonic Polyps / Q000175:diagnosis / Q000473:pathology; D015179:Colorectal Neoplasms / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D006801:Humans; D007557:Israel; D008403:Mass Screening / Q000379:methods*; D010348:Patient Care Team / Q000458:organization & administration; D012306:Risk