title: Control of host inflammatory responsiveness by indigenous microbiota reveals an adaptive component of the innate immune system.
abstract: We are not alone. The indigenous microbiota colonizes exposed surfaces and aids their hosts in several physiological activities. The transition between a non-colonized to a colonized state is associated with modification on the pattern of host inflammatory responsiveness. Therefore, innate immunity adapts to the colonized state of the host, suggesting that there is an acquired component in innate immune responses.
authors.affiliation: Immunopharmacology, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627 - Pampulha, 31270-901 Belo Horizonte, MG, Brazil.
authors.forename: Caio T
authors.initials: CT
authors.lastname: Fagundes
authors.forename: Danielle G
authors.initials: DG
authors.lastname: Souza
authors.forename: Jacques R
authors.initials: JR
authors.lastname: Nicoli
authors.forename: Mauro M
authors.initials: MM
authors.lastname: Teixeira
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D001419:Bacteria / Q000276:immunology*; D015373:Bacterial Typing Techniques; D016207:Cytokines / Q000276:immunology; D005856:Germ-Free Life / Q000276:immunology; D006801:Humans; D007107:Immune System / Q000382:microbiology* / Q000502:physiology; D007113:Immunity, Innate; D018928:Immunity, Mucosal; D007249:Inflammation / Q000276:immunology* / Q000382:microbiology; D007413:Intestinal Mucosa / Q000276:immunology / Q000382:microbiology; D054892:Metagenome; D051379:Mice; D013559:Symbiosis / Q000276:immunology*
chemical_list: D016207:Cytokines