title: Imatinib-associated hyperpigmentation of the palate in post-HSCT patient.
abstract: Pigmentation of the oral mucosa can indicate a wide range of lesions or conditions. Some drugs are associated with pigmented lesions of oral cavity. Imatinib mesylate (Gleevec(®)) is a protein inhibitor used in the management of several hematological malignancies associated with dermatological side effects, like hyperpigmentation. We report the case of a 38-year-old male post-HSCT patient who had been using imatinib mesylate for over 5 years and presented with blue pigmentation on the hard palate, the left side of the nose and both ear lobes. The differential diagnosis of hyperpigmented lesions in the oral mucosa is also presented.
authors.affiliation: Department of Oral Surgery and Pathology, School of Dentistry (Prof. Evandro Abdo, Dean), Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627, Belo Horizonte-MG CEP 31270 901, Brazil.
authors.forename: Renata Gonçalves
authors.initials: RG
authors.lastname: Resende
authors.forename: Raissa Gabriela Lopes
authors.initials: RG
authors.lastname: Teixeira
authors.forename: Fabiana de Oliveira
authors.initials: Fde O
authors.lastname: Vasconcelos
authors.forename: Maria Elisa de Souza
authors.initials: ME
authors.lastname: Silva
authors.forename: Mauro Henrique Guimarães
authors.initials: MH
authors.lastname: Abreu
authors.forename: Ricardo Santiago
authors.initials: RS
authors.lastname: Gomez
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001549:Benzamides; D004427:Ear Diseases / Q000139:chemically induced; D004431:Ear, External / Q000187:drug effects; D005148:Facial Dermatoses / Q000139:chemically induced; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced*; D000068877:Imatinib Mesylate; D008297:Male; D008439:Maxillary Diseases / Q000139:chemically induced*; D016609:Neoplasms, Second Primary / Q000473:pathology; D009456:Neurofibromatosis 1 / Q000473:pathology; D009668:Nose Diseases / Q000139:chemically induced; D021362:Palate, Hard / Q000187:drug effects*; D010879:Piperazines / Q000009:adverse effects*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000601:surgery; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D011743:Pyrimidines / Q000009:adverse effects*; D014016:Tissue Conditioning, Dental
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D011505:Protein-Tyrosine Kinases