title: Reversible Symptomatic Myocarditis Induced by All-Trans Retinoic Acid Administration during Induction Treatment of Acute Promyelocytic Leukemia: Rare Cardiac Manifestation as a Retinoic Acid Syndrome.
abstract: Treatment by All-trans retinoic acid (ATRA) followed by anthracycline-AraC chemotherapy has improved the outcome of acute promyelocytic leukemia. ATRA is usually well tolerated, but a few major side effects can be observed. Retinoic acid syndrome (RAS) often occurs during the induction chemotherapy of acute promyelocytic leukemia. A pericardial effusion is a common cardiac manifestation but myocarditis has been rarely documented. Here we reports a very rare case of fully recovered myocarditis as a result of RAS related to ATRA administration during induction treatment of acute promyelocytic leukemia which documented by echocardiographic evidence.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
authors.forename: Seonghoon
authors.initials: S
authors.lastname: Choi
authors.forename: Hyeong-Su
authors.initials: HS
authors.lastname: Kim
authors.forename: Chang-Soo
authors.initials: CS
authors.lastname: Jung
authors.forename: Seong-Woong
authors.initials: SW
authors.lastname: Jung
authors.forename: Yun-Ja
authors.initials: YJ
authors.lastname: Lee
authors.forename: Jin-Kyeong
authors.initials: JK
authors.lastname: Rheu
authors.forename: Jung-Rae
authors.initials: JR
authors.lastname: Jo
authors.forename: Nam-Ho
authors.initials: NH
authors.lastname: Lee