title: Determination of whether the association between serum albumin and activities of daily living in frail elderly people is causal.
abstract: OBJECTIVE
  Serum albumin and activities of daily living (ADL) are associated with each other, but whether the association is causal is not known. The purpose of this study was to determine whether a causal association exists between serum albumin and ADL levels.
  
  
  METHODS
  The subjects were 116 frail elderly individuals (34 men and 82 women; mean age 83.0 years). Demographic characteristics, serum albumin, ADL, and handgrip strength were measured at a baseline examination and at a follow-up examination 2 years later. Levels of ADL were assessed with the Barthel Index. Pearson's correlation coefficients were calculated for serum albumin, ADL, and handgrip strength for baseline values and for their 2-year changes (Δ).
  
  
  RESULTS
  At baseline, the mean serum albumin concentration was 4.0 g/dL and the total score of the Barthel Index (baseline Barthel Index) was 71.1. The baseline serum albumin level correlated significantly with the baseline Barthel Index (r = 0.287) and baseline handgrip strength (r = 0.315), but not with Δ Barthel Index (r = 0.096) or Δ handgrip strength (r = - 0.058). The Δ serum albumin correlated significantly with Δ Barthel Index (r = 0.296), but not with Δ handgrip strength (r = 0.182), baseline Barthel Index (r = - 0.044), or baseline handgrip strength (r = 0.047).
  
  
  CONCLUSIONS
  This 2-year cohort study has demonstrated that a decrease in serum albumin levels is associated with a decrease in ADL levels. A third factor may play a role in adversely affecting both serum albumin and ADL levels in frail elderly people.
authors.affiliation: Department of Nursing, Niigata University of Health and Welfare, 1398 Shimami-cho, Kita-ku, Niigata 951-3198, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Kitamura
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Nakamura
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nishiwaki
authors.forename: Kimiko
authors.initials: K
authors.lastname: Ueno
authors.forename: Akemi
authors.initials: A
authors.lastname: Nakazawa
authors.forename: Mariko
authors.initials: M
authors.lastname: Hasegawa
mesh_terms: D000203:Activities of Daily Living; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D016330:Frail Elderly; D015577:Geriatric Assessment; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D053580:Muscle Strength; D012307:Risk Factors; D012709:Serum Albumin / Q000032:analysis*
chemical_list: D012709:Serum Albumin