title: [Guidelines for diagnosis, treatment, surveillance and prevention of cancer in patients with familial non-adenomatous polyposis].
abstract: Approximately 30% of colorectal cancers exhibit familial clustering. Currently, we recognize a number of different types of polyps and polyposis syndromes that are classified according to the histology of the typical polyp. We differentiate between adenomas, hyperplastic, and hamartomatous polyps as well as between syndromes that are manifested by 10-100 or above 100 polyps. It is essential to distinguish between these syndromes as each has a different mode of presentation, spectrum of signs and symptoms and cancer risk associated with them. With the knowledge accumulating, we now have the tools to lower the risk of cancer by performing specific screening programs that are tailored to each syndrome. In these guidelines we focus on the non-adenomatous polyps, hyperplastic and hamartomatous polyposis syndromes. We outline the importance of multi-sector team work that includes the family practitioner, gastroenterologist, pathologist, genetic counselor, surgeon, and social worker.
authors.affiliation: The Section of Gastrointestinal Oncology, the Israeli Gastroenterology Association.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Half
authors.forename: Yael
authors.initials: Y
authors.lastname: Goldberg
authors.forename: Revital
authors.initials: R
authors.lastname: Kariv
authors.forename: Ornit
authors.initials: O
authors.lastname: Cohen-Ezra
authors.forename: Alex
authors.initials: A
authors.lastname: Vilkin
authors.forename: Zohar
authors.initials: Z
authors.lastname: Levi
authors.forename: Menachem
authors.initials: M
authors.lastname: Moshkowitz
authors.forename: Yaron
authors.initials: Y
authors.lastname: Niv
mesh_terms: D003111:Colonic Polyps / Q000175:diagnosis / Q000473:pathology; D015179:Colorectal Neoplasms / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D006801:Humans; D006965:Hyperplasia; D044483:Intestinal Polyposis / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D007557:Israel; D008403:Mass Screening / Q000379:methods; D010348:Patient Care Team / Q000458:organization & administration; D010580:Peutz-Jeghers Syndrome / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D012306:Risk