title: Investigative clinical pharmacology.
abstract: Clinical pharmacology is an essential discipline in the development of new medicines, but the closely specified requirements of pharmaceutical industry protocols and regulatory reviewers have limited the opportunities for curiosity-driven research. Realization is growing that there is so much that is not known about the mechanisms underlying human disease and the actions of medicines on them that research of a more exploratory kind, namely, investigative clinical pharmacology, is a priority.
authors.affiliation: GlaxoSmithKline R&D, Stevenage, UK. colin.dollery@gsk.com
authors.forename: C
authors.initials: C
authors.lastname: Dollery
mesh_terms: D000485:Allergens / Q000276:immunology*; D001095:Arachidonic Acids / Q000378:metabolism*; D001249:Asthma / Q000276:immunology*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D063385:Cannabinoid Receptor Modulators / Q000378:metabolism*; D063388:Endocannabinoids; D006801:Humans; D053284:Polyunsaturated Alkamides / Q000378:metabolism*; D043885:Receptor, Cannabinoid, CB2 / Q000378:metabolism*
chemical_list: D000485:Allergens; D001095:Arachidonic Acids; D063385:Cannabinoid Receptor Modulators; D063388:Endocannabinoids; D053284:Polyunsaturated Alkamides; D043885:Receptor, Cannabinoid, CB2; C078814:anandamide