title: Intergenerational anticipation of disease onset in people with multiple autoimmune syndrome.
abstract: We compared the intergenerational variations of the clinical phenotype between 30 patients affected with multiple autoimmune syndrome (MAS) and their affected first- and second-degree relatives. Mean age at onset was always significantly higher in the previous generation than in probands for all the considered diseases.
authors.affiliation: Department of Pediatrics, Federico II University, via S Pansini 5-80131, Naples, Italy.
authors.forename: Giuliana
authors.initials: G
authors.lastname: Giardino
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Aloj
authors.forename: Emilia
authors.initials: E
authors.lastname: Cirillo
authors.forename: Donatella
authors.initials: D
authors.lastname: Capalbo
authors.forename: Filomena
authors.initials: F
authors.lastname: Maio
authors.forename: Mariacarolina
authors.initials: M
authors.lastname: Salerno
authors.forename: Adriana
authors.initials: A
authors.lastname: Franzese
authors.forename: Claudio
authors.initials: C
authors.lastname: Pignata
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D002446:Celiac Disease / Q000453:epidemiology / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D040941:Heredity; D006801:Humans; D007558:Italy / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D008297:Male; D010375:Pedigree; D010641:Phenotype; D012189:Retrospective Studies; D013577:Syndrome; D013967:Thyroiditis, Autoimmune / Q000453:epidemiology / Q000235:genetics; D055815:Young Adult