title: [Actiprotective and antihypoxic action of new heteroaromatic antioxidants].
abstract: Expernents with mice showed that most of 15 new heteroaromatic antioxidant compounds possess aciprotective and antixopixic properties. Based on results of treadmill and swimming tests, actiprotective action of IBKhF-1, 11 and 14 surpassed greatly bemythil and bromanthane in ordinary conditions. Inhibitor of gluconeogenase tryptophan cancelled largely the stimulatting action of highly effective and active IBKhF-1, 2 and 11 on physical performance during treadmill exercise. Consequently, gluconeogenesis activation is one of the major components of the actiprotective action of these antioxidants. In addition, IBKhF-1, 11 and 14 excelled bemythil and bromanthane in the extreme conditions of running in hyperthermia and swimming in acute hypoxia combined with hypercapnia. IBKhF-2 and 14 were better than amtisol (standard antihypoxic agent) and bemythil against acute hypoxia in pressure chamber, whereas IBKhF-4 and 14 excelled these agents in thermal chamber.
authors.forename: V V
authors.initials: VV
authors.lastname: Iasnetsov
authors.forename: E G
authors.initials: EG
authors.lastname: Tsublova
authors.forename: Vik V
authors.initials: VV
authors.lastname: Iasnetsov
authors.forename: S K
authors.initials: SK
authors.lastname: Karsanova
authors.forename: S Ia
authors.initials: SIa
authors.lastname: Skachilova
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004195:Disease Models, Animal; D006935:Hypercapnia / Q000378:metabolism / Q000517:prevention & control; D000860:Hypoxia / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D051379:Mice; D005082:Physical Exertion
chemical_list: D000975:Antioxidants