title: Hyperhidrosis plantaris - a randomized, half-side trial for efficacy and safety of an antiperspirant containing different concentrations of aluminium chloride.
abstract: BACKGROUND
  Primary focal hyperhidrosis plantaris can cause impairment in social, physical, leisure and occupational activities. Topical treatment with aluminium chloride is the first-line treatment. The aim of this trial was to evaluate efficacy and safety of two different concentrations of aluminium chloride hexa-hydrate (12.5%, 30%) for 6 weeks.
  
  
  METHODS
  20 volunteers with hyperhidrosis plantaris were included. Efficacy was evaluated using a clinical rating scale of the hyperhidrosis level and qualitative assessments including Minor's (iodine-starch) test and a standardized sniff test. Furthermore a patient questionnaire and measurements of skin surface pH were done to evaluate the subjective assessments and side effects.
  
  
  RESULTS
  The hyperhidrosis level significantly decreased in both concentrations. There were no differences in tolerability regarding the skin surface pH and the patient questionnaires. In addition the hidrotic areas decreased after application of both products and the sniff test improved.
  
  
  CONCLUSIONS
  Topical application of an antiperspirant containing aluminium chloride reduced sweat production in plantar hyperhidrosis significantly. As both 12.5% and 30% were efficacious and safe, we would recommend 12.5% for outpatient treatment.
authors.affiliation: Cosmetic Science (FB 13), University of Hamburg, Germany.
authors.forename: Meike
authors.initials: M
authors.lastname: Streker
authors.forename: Tilmann
authors.initials: T
authors.lastname: Reuther
authors.forename: Linda
authors.initials: L
authors.lastname: Hagen
authors.forename: Martina
authors.initials: M
authors.lastname: Kerscher
mesh_terms: D000328:Adult; D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry; D051520:Antiperspirants / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D002712:Chlorides / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006945:Hyperhidrosis / Q000175:diagnosis* / Q000628:therapy*; D008297:Male; D016896:Treatment Outcome
chemical_list: D017607:Aluminum Compounds; D051520:Antiperspirants; D002712:Chlorides; D000077410:Aluminum Chloride