title: Association between tryptophan hydroxylase-2 gene and late-onset depression.
abstract: OBJECTIVE
  The aim of this study was to examine the association between polymorphisms (SNP) in the tryptophan hydroxylase-2 (TPH2) gene and late-onset depression (LOD) in the Brazilian population.
  
  
  METHODS
  We genotyped 8 tag SNPs in the TPH2 gene in 84 outpatients with LOD and 79 individuals belonging to the comparison group to investigate an association between the TPH2 gene and LOD.
  
  
  RESULTS
  Our findings suggested an association between tag SNP rs4565946 heterozygous C/T (p = 0.034; χ2 = 6.7; df = 2) and decreased risk of LOD. The tag SNP rs11179000 ancestral homozygous A/A (p = 0.025; χ2 = 7.3; df = 2) and increase risk of LOD and allelic association of ancestral allele A and increase risk of LOD was demonstrated (p = 0.005; χ2 = 7.8; df = 1).
  
  
  CONCLUSIONS
  We found the statistically significant association between two tag SNPs and LOD. Our results support the hypothesis that the TPH2 gene is associated with LOD.
authors.affiliation: Laboratório de Neurociência, INCT-Instituto Nacional de Ciência e Tecnologia de Medicina Molecular, Faculdade de Medicina, Departamento de Saúde Mental, Universidade Federal de Minas Gerais (UFMG), Av Alfredo Balena, 190, Belo Horizonte-MG, 30130, Brazil. patriciabiomol@yahoo.com.br
authors.forename: Patricia de Araújo
authors.initials: Pde A
authors.lastname: Pereira
authors.forename: Marco Aurélio
authors.initials: MA
authors.lastname: Romano-Silva
authors.forename: Maria Aparecida Camargos
authors.initials: MA
authors.lastname: Bicalho
authors.forename: Luiz
authors.initials: L
authors.lastname: De Marco
authors.forename: Humberto
authors.initials: H
authors.lastname: Correa
authors.forename: Simone Becho
authors.initials: SB
authors.lastname: de Campos
authors.forename: Edgar Nunes
authors.initials: EN
authors.lastname: de Moraes
authors.forename: Karen Cecilia de Lima
authors.initials: KC
authors.lastname: Torres
authors.forename: Bruno Rezende
authors.initials: BR
authors.lastname: de Souza
authors.forename: Debora Marques
authors.initials: DM
authors.lastname: de Miranda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D016022:Case-Control Studies; D003863:Depression / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D014365:Tryptophan Hydroxylase / Q000235:genetics*
chemical_list: C494784:TPH2 protein, human; D014365:Tryptophan Hydroxylase