title: Measurements of immune responses for establishing correlates of vaccine protection against HIV.
abstract: Well-defined correlates of protective immunity are an essential component of rational vaccine development. Despite years of basic science and three HIV vaccine efficacy trials, correlates of immunological protection from HIV infection remain undefined. In December 2010, a meeting of scientists engaged in basic and translational work toward developing HIV-1 vaccines was convened. The goal of this meeting was to discuss current opportunities and optimal approaches for defining correlates of protection, both for ongoing and future HIV-1 vaccine candidates; specific efforts were made to engage young scientists. We discuss here the highlights from the meeting regarding the progress made and the way forward for a protective HIV-1 vaccine.
authors.affiliation: Institute of Infectious Diseases and Molecular Medicine and Division of Medical Virology, University of Cape Town, Cape Town, South Africa.
authors.forename: Wendy A
authors.initials: WA
authors.lastname: Burgers
authors.forename: Amapola
authors.initials: A
authors.lastname: Manrique
authors.forename: David
authors.initials: D
authors.lastname: Masopust
authors.forename: Lyle R
authors.initials: LR
authors.lastname: McKinnon
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Reynolds
authors.forename: Morgane
authors.initials: M
authors.lastname: Rolland
authors.forename: Catherine
authors.initials: C
authors.lastname: Blish
authors.forename: Gerald K
authors.initials: GK
authors.lastname: Chege
authors.forename: Rhonda
authors.initials: R
authors.lastname: Curran
authors.forename: William
authors.initials: W
authors.lastname: Fischer
authors.forename: Carolina
authors.initials: C
authors.lastname: Herrera
authors.forename: D Noah
authors.initials: DN
authors.lastname: Sather
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology; D005260:Female; D005822:Genetic Vectors; D006679:HIV Seropositivity / Q000188:drug therapy / Q000276:immunology*; D015497:HIV-1 / Q000187:drug effects / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D018928:Immunity, Mucosal / Q000187:drug effects; D007156:Immunologic Memory; D008297:Male; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology
chemical_list: D016915:AIDS Vaccines; D014614:Vaccines, Synthetic