title: [Endometrial microvessel density for assessing endometrial receptivity during the peri-implantation period].
abstract: OBJECTIVE
  To evaluate the value of endometrial microvessel density (MVD) in assessing the endometrial receptivity during the peri-implantation period.
  
  
  METHODS
  A total of 104 patients undergoing in vitro fertilization and embryo transfer (IVF-ET) treatment were analyzed retrospectively. The subjects were divided into clinical pregnancy group (50 cases) and nonpregnant group (54 cases) according to the IVF-ET outcome. Endometrial tissues were collected 7 days after the natural ovulation prior to IVF-ET for measurement of the endometrial MVD using electron microscopy, which was analyzed in relation to the clinical outcome of the treatment.
  
  
  RESULTS
  The endometrial MVD was significantly higher in the clinical pregnancy group than in the nonpregnant group [(4.12∓1.84)% vs (3.46∓1.26)%, t=-2.127, P=0.036). ROC curve analysis showed that the MVD had an area under the curve slightly over 0.5 (0.598) for predicting clinical pregnancy, suggesting a poor specificity in predicting the clinical outcome of the treatment.
  
  
  CONCLUSIONS
  In IVF-ET cycles, the endometrial MVD during the peri-implantation period is helpful for assessing the endometrial receptivity, but the specificity remains low.
authors.affiliation: Department of Obstetrics and Gynecology, Southern Medical University, Guangzhou, China. liqiuhua1320@yahoo.com.cn
authors.forename: Qiu-hua
authors.initials: QH
authors.lastname: Li
authors.forename: Min
authors.initials: M
authors.lastname: Yu
authors.forename: Lei-ning
authors.initials: LN
authors.lastname: Chen
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.forename: Chen
authors.initials: C
authors.lastname: Luo
authors.forename: Si-mei
authors.initials: SM
authors.lastname: Chen
authors.forename: Song
authors.initials: S
authors.lastname: Quan
mesh_terms: D000328:Adult; D010064:Embryo Implantation / Q000502:physiology*; D004624:Embryo Transfer; D004717:Endometrium / Q000098:blood supply* / Q000502:physiology; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy; D055806:Microvessels / Q000648:ultrastructure*; D012189:Retrospective Studies; D014463:Ultrasonography