title: Cohesin: a critical chromatin organizer in mammalian gene regulation.
abstract: Cohesins are evolutionarily conserved essential multi-protein complexes that are important for higher-order chromatin organization. They play pivotal roles in the maintenance of genome integrity through mitotic chromosome regulation, DNA repair and replication, as well as gene regulation critical for proper development and cellular differentiation. In this review, we will discuss the multifaceted functions of mammalian cohesins and their apparent functional hierarchy in the cell, with particular focus on their actions in gene regulation and their relevance to human developmental disorders.
authors.affiliation: Department of Biological Chemistry, School of Medicine, University of California, Irvine, California 92697-1700, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Chien
authors.forename: Weihua
authors.initials: W
authors.lastname: Zeng
authors.forename: Alexander R
authors.initials: AR
authors.lastname: Ball
authors.forename: Kyoko
authors.initials: K
authors.lastname: Yokomori
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism* / Q000494:pharmacology; D002843:Chromatin / Q000737:chemistry / Q000378:metabolism*; D042002:Chromatin Assembly and Disassembly / Q000187:drug effects*; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism* / Q000494:pharmacology; D005786:Gene Expression Regulation; D006801:Humans; D000097722:Cohesins
chemical_list: D018797:Cell Cycle Proteins; D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D000097722:Cohesins