title: Visceral hypersensitivity in endometriosis: a new target for treatment?
abstract: OBJECTIVE
  In women presenting to gynaecological clinics with lower abdominal pain, the cause is frequently attributed to endometriosis irrespective of whether it is found to be minimal or extensive at laparoscopy. Irritable bowel syndrome (IBS) is also common in this setting, and it was speculated that the visceral hypersensitivity associated with this condition might be amplifying the symptoms of endometriosis.
  
  
  METHODS
  Visceral sensitivity to balloon distension, symptoms and psychological status were assessed following laparoscopy in 20 women with minimal to mild endometriosis, 20 with moderate to severe endometriosis, 20 with laparoscopy negative abdominal pain and 20 asymptomatic women undergoing laparoscopic sterilisation who acted as controls, and compared with 20 women with IBS.
  
  
  RESULTS
  Compared with controls, patients with minimal to mild and moderate to severe endometriosis had a higher prevalence of symptoms consistent with IBS (0% vs 65% and 50%, respectively, p<0.001) with significantly lower mean pain thresholds (39.5 mm Hg (95% CI 36.0 to 43.0) vs 28.1 mm Hg (95% CI 24.5 to 31.6), p=0.001 and 28.8 mm Hg (95% CI 24.9 to 32.6), p=0.002) not explained by differences in rectal compliance. Patients with laparoscopy negative pain had symptoms and visceral sensitivity similar to patients with IBS. Controls undergoing laparoscopy had normal sensitivity, indicating that the laparoscopic procedure was not inducing hypersensitivity.
  
  
  CONCLUSIONS
  Visceral hypersensitivity is extremely common in endometriosis and could be intensifying the pain. This finding might explain why mildly affected individuals often complain of severe symptoms out of proportion to the extent of their disease. This study has introduced a completely new concept into the understanding of pain in endometriosis and could open up new opportunities for treatment.
authors.affiliation: Department of Translational Medicine, University of Manchester, Manchester, UK.
authors.forename: B
authors.initials: B
authors.lastname: Issa
authors.forename: T S
authors.initials: TS
authors.lastname: Onon
authors.forename: A
authors.initials: A
authors.lastname: Agrawal
authors.forename: C
authors.initials: C
authors.lastname: Shekhar
authors.forename: J
authors.initials: J
authors.lastname: Morris
authors.forename: S
authors.initials: S
authors.lastname: Hamdy
authors.forename: P J
authors.initials: PJ
authors.lastname: Whorwell
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004106:Dilatation / Q000009:adverse effects; D004715:Endometriosis / Q000150:complications* / Q000523:psychology; D005260:Female; D006801:Humans; D006930:Hyperalgesia / Q000209:etiology* / Q000523:psychology; D043183:Irritable Bowel Syndrome / Q000150:complications; D010535:Laparoscopy / Q000009:adverse effects; D008875:Middle Aged; D010147:Pain Measurement / Q000379:methods; D017288:Pain Threshold; D012684:Sensory Thresholds; D014781:Viscera / Q000294:innervation*; D055815:Young Adult