title: Anti-VEGF and beyond: shaping a new generation of anti-angiogenic therapies for cancer.
abstract: The anti-angiogenic class of drugs is one of the few where representatives have gained international approval for clinical use in oncology during the past decade. Most of the biological and clinical activity of the currently available generation of anti-angiogenic drugs targets vascular endothelial growth factor (VEGF) and its related pathways. However, the clinical benefits associated with the use of these drugs have, so far, been limited. There is, therefore, an unmet need for biomarkers that can be used to identify patients who are most likely to benefit therapeutically and also to predict the best schedule and dosage for these drugs. Here, we discuss some of the emerging new combination strategies involving the approved anti-angiogenic drugs, some of the emerging targets associated with neoplastic angiogenesis and some novel agents used as a paradigm of the next generation of anti-angiogenic drugs.
authors.affiliation: Laboratory of Hematology-Oncology and Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy. francesco.bertolini@ieo.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Bertolini
authors.forename: Paola
authors.initials: P
authors.lastname: Marighetti
authors.forename: Ines
authors.initials: I
authors.lastname: Martin-Padura
authors.forename: Patrizia
authors.initials: P
authors.lastname: Mancuso
authors.forename: Dana D
authors.initials: DD
authors.lastname: Hu-Lowe
authors.forename: Yuval
authors.initials: Y
authors.lastname: Shaked
authors.forename: Alberto
authors.initials: A
authors.lastname: D'Onofrio
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000098:blood supply* / Q000188:drug therapy* / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000188:drug therapy; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D042461:Vascular Endothelial Growth Factor A