title: [Effects of resveratrol on lipid metabolism in C57BL/6J mice].
abstract: OBJECTIVE
  To investigate the effects of resveratrol on serum and liver lipids in C57BL/6J mice.
  
  
  METHODS
  30 male C57BL/6J mice were randomly assigned to the following three groups: control group given a normal diet, high-fat diet group and resveratrol group (22.5 mg/kg BW) were given high fat diet. the resveratrol were dissolved in 0.5% sodium carboxymethyl cellulose and were given to the Resveratrol group by intragastric administration. The levels of serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), the levels of TG and TC in liver, and the pathological changes of liver were measured after the treatment lasted for 8 weeks.
  
  
  RESULTS
  The serum TC, LDL-C, HDL-C levels of high-fat diet and resveratrol groups were higher than those of control group (P < 0.05), and the serum TC and LDL-C levels of high-fat diet were also higher than those of resveratrol group (P < 0. 05). But the serum TG levels of high-fat diet and resveratrol groups were lower than those of control group (P < 0.05). The TC content of liver in high-fat diet group were higher than those of control and resveratrol groups (P < 0.05).
  
  
  CONCLUSIONS
  The TC content in C57BL/6J mice can be decreased by resveratrol (22.5 mg/kg BW).
authors.affiliation: Department of Nutrition and Food hygiene, School of Public Health, China Medical University, Shenyang 110001, China. renyahao0512@sohu.com
authors.forename: Yahao
authors.initials: Y
authors.lastname: Ren
authors.forename: Yanxi
authors.initials: Y
authors.lastname: Li
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhao
authors.forename: Fei
authors.initials: F
authors.lastname: Yu
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Zhan
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yuan
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002784:Cholesterol / Q000032:analysis / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage; D006937:Hypercholesterolemia / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D050356:Lipid Metabolism / Q000187:drug effects*; D008099:Liver / Q000737:chemistry; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology* / Q000627:therapeutic use; D014280:Triglycerides / Q000032:analysis / Q000097:blood
chemical_list: D000924:Anticholesteremic Agents; D004041:Dietary Fats; D013267:Stilbenes; D014280:Triglycerides; D002784:Cholesterol; D000077185:Resveratrol