title: The metabolic syndrome of fructose-fed rats: effects of long-chain polyunsaturated ω3 and ω6 fatty acids. I. Intraperitoneal glucose tolerance test.
abstract: The present series of experiments aim mainly at investigating the possible             influence of changes in the com-position of dietary lipids (sunflower oil, salmon             oil, safflower oil) upon the metabolic syndrome found in rats exposed to a fructose-rich             diet. For purpose of comparison, a control group of rats received the sunflower             oil diet with substitution of fructose by starch. An intraperitoneal glucose tolerance             test, performed after overnight starvation fifty days after the start of the experiments             at the 6th week after birth, indicated, as expected, impaired tolerance to glucose             and deterioration of insulin sensitivity (HOMA index), without changes in the             insulinogenic index, when comparing the fructose-fed rats to the starch-fed rats             both exposed to the sunflower oil diet. In the fructose-fed rats, enrichment of             the diet by long-chain polyunsaturated ω3 fatty acids supplied by salmon oil,             a modest improvement of insulin sensitivity was opposed, in term of glucose homeostasis,             by a decreased secretory response to glucose of insulin-producing cells. Last,             in the fructose-fed rats, the partial substitution of sunflower oil by safflower             oil rich in long-chain polyunsaturated ω6 fatty acids further deteriorated glucose             homeostasis, with a higher mean HOMA index and a severe decrease of the insulinogenic             index. These findings justify further investigations on such items as the time             course for changes in metabolic and hormonal variables and both the metabolic             and secretory responses of isolated pancreatic islets to selected nutrient secretagogues.
authors.affiliation: Department of Biology, Es-Sénia University, Oran, Algeria.
authors.forename: Zoheir
authors.initials: Z
authors.lastname: Mellouk
authors.forename: Tarek
authors.initials: T
authors.lastname: Hachimi Idrissi
authors.forename: Karim
authors.initials: K
authors.lastname: Louchami
authors.forename: Emeline
authors.initials: E
authors.lastname: Hupkens
authors.forename: Willy J
authors.initials: WJ
authors.lastname: Malaisse
authors.forename: Dalila
authors.initials: D
authors.lastname: Ait Yahia
authors.forename: Abdullah
authors.initials: A
authors.lastname: Sener
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004041:Dietary Fats / Q000378:metabolism*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage* / Q000378:metabolism; D043371:Fatty Acids, Omega-6 / Q000008:administration & dosage* / Q000378:metabolism; D005260:Female; D005395:Fish Oils / Q000378:metabolism; D005632:Fructose / Q000009:adverse effects / Q000378:metabolism*; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells / Q000378:metabolism; D024821:Metabolic Syndrome / Q000139:chemically induced / Q000378:metabolism*; D010938:Plant Oils / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012450:Safflower Oil / Q000378:metabolism; D000074242:Sunflower Oil; D014280:Triglycerides / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005395:Fish Oils; D007328:Insulin; D010938:Plant Oils; D000074242:Sunflower Oil; D014280:Triglycerides; D005632:Fructose; C030341:salmon oil; D012450:Safflower Oil