title: Ocular surface squamous neoplasia in a young adult - its nature and unusual course.
abstract: BACKGROUND
  We describe a case of a recurrent ocular surface squamous neoplasia (OSSN) in a 37-year-old male with a mass at the infero-temporal quadrant along with an isolated primary lesion at the upper nasal quadrant for the last five months with a past history of surgical excision 7 years ago for a nodular mass in the same eye. The mass showed delayed response to Mitomycin C (MMC) therapy and finally developed limbal stem cell deficiency.
  
  
  METHODS
  A 37-year-old male presented with a five-month history of foreign body sensation and localized conjunctival hyperemia and two progressively enlarging bumps over the limbus in the left eye. The past history stated a surgical excision , done 7 years ago, for a nodular mass cytology. The patient received initial treatment with 0.02% MMC, but did not show any improvement even after 3 cycles, but later showed marked chemoreduction with 0.04% MMC on two cycles and a complete resolution of the neoplasia after two more cycles. Impression cytology at six months revealed no abnormality. But at the 10-month follow-up. limbal stem cell deficiency was observed.
  
  
  CONCLUSIONS
  While examining, managing and follow-up of a case of OSSN, one needs to know the atypical nature and response of the tumour. Long-term follow-up in these cases is mandatory.
authors.affiliation: Dr RP Center for Ophthalmic Sciences, AIIMS, New Delhi, India.
authors.forename: A
authors.initials: A
authors.lastname: Panda
authors.forename: N K
authors.initials: NK
authors.lastname: Sasikala
mesh_terms: D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D018450:Disease Progression; D005134:Eye Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D006801:Humans; D016850:Limbus Corneae / Q000473:pathology* / Q000601:surgery; D008297:Male; D016685:Mitomycin / Q000627:therapeutic use; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D013234:Stem Cells / Q000473:pathology
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin