title: The use of the orthotopic model to validate antivascular therapies for cancer.
abstract: The orthotopic model reproduces aspects of the tumour microenvironment and emulates a number of important biological features of cancer progression, angiogenesis, metastasis and resistance. Due to its parallels with human cancer, the model can be used to evaluate therapeutic responses to various therapies. This review outlines the importance of using the orthotopic implantation of tumour cells in mice models for evaluating the effectiveness of antivascular therapies.
authors.affiliation: Laboratory of Oncology, G. Gaslini Children's Hospital, Genoa, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Loi
authors.forename: Daniela
authors.initials: D
authors.lastname: Di Paolo
authors.forename: Pamela
authors.initials: P
authors.lastname: Becherini
authors.forename: Alessia
authors.initials: A
authors.lastname: Zorzoli
authors.forename: Patrizia
authors.initials: P
authors.lastname: Perri
authors.forename: Roberta
authors.initials: R
authors.lastname: Carosio
authors.forename: Michele
authors.initials: M
authors.lastname: Cilli
authors.forename: Domenico
authors.initials: D
authors.lastname: Ribatti
authors.forename: Chiara
authors.initials: C
authors.lastname: Brignole
authors.forename: Gabriella
authors.initials: G
authors.lastname: Pagnan
authors.forename: Mirco
authors.initials: M
authors.lastname: Ponzoni
authors.forename: Fabio
authors.initials: F
authors.lastname: Pastorino
mesh_terms: D020533:Angiogenesis Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D009368:Neoplasm Transplantation / Q000379:methods; D009374:Neoplasms, Experimental / Q000098:blood supply* / Q000188:drug therapy*; D009389:Neovascularization, Pathologic / Q000628:therapy; D059016:Tumor Microenvironment; D023041:Xenograft Model Antitumor Assays
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents