title: Salivary endothelin-1 potential for detecting oral cancer in patients with oral lichen planus or oral cancer in remission.
abstract: Endothelin-1 (ET-1) is a potent vasoconstrictor involved not only in vascular biology but also in carcinogenesis. Results of a study in 2007 suggested salivary ET-1 as a potential biomarker for oral squamous cell carcinoma (OSCC), but a later study showed conflicting results. The purpose of our pilot study was to investigate feasibility of using salivary ET-1 as a biomarker for OSCC in two groups: oral lichen planus (OLP) patients and patients with OSCC in remission. Saliva samples were collected from five groups of subjects: patients with newly diagnosed, active OSCC (Group A); patients with OSCC in remission (Group B); patients with active OLP lesions (Group C); patients with OLP in remission (Group D); and normal controls (Group E). Salivary ET-1 levels were determined by enzyme-linked immunosorbent assay, and the results were analyzed by the Mann-Whitney U test. The mean salivary ET-1 level in Group A was significantly higher than that found in Group C (p=0.001), Group D (p=0.015) or Group E (p=0.004). There were no significant differences (p>0.05) in the mean salivary ET-1 levels between Groups A and B; Groups B and C; Groups B and D; Groups B and E; Groups C and D; Groups C and E; or Groups D and E. Salivary ET-1 could be a good biomarker for OSCC development in OLP patients regardless of the degree of OLP disease activity. However, it appeared not to be a good biomarker for detecting recurrence of OSCC in patients in remission.
authors.affiliation: Department of Diagnostic Sciences, Texas A&M Health Science Center, Baylor College of Dentistry, Dallas, TX, USA. ycheng@bcd.tamhsc.edu
authors.forename: Yi-Shing Lisa
authors.initials: YS
authors.lastname: Cheng
authors.forename: Terry
authors.initials: T
authors.lastname: Rees
authors.forename: Lee
authors.initials: L
authors.lastname: Jordan
authors.forename: Lance
authors.initials: L
authors.lastname: Oxford
authors.forename: John
authors.initials: J
authors.lastname: O'Brien
authors.forename: Huey-Shys
authors.initials: HS
authors.lastname: Chen
authors.forename: David
authors.initials: D
authors.lastname: Wong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000378:metabolism; D016022:Case-Control Studies; D019332:Endothelin-1 / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D017676:Lichen Planus, Oral / Q000175:diagnosis* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000378:metabolism; D010865:Pilot Projects; D012463:Saliva / Q000737:chemistry*
chemical_list: D015415:Biomarkers; D019332:Endothelin-1