title: Are Toll-like receptors and decoy receptors involved in the immunopathogenesis of systemic lupus erythematosus and lupus-like syndromes?
abstract: In this paper we focus our attention on the role of two families of receptors, Toll-like receptors (TLR) and decoy receptors (DcR) involved in the generation of systemic lupus erythematosus (SLE) and lupus-like syndromes in human and mouse models. To date, these molecules were described in several autoimmune disorders such as rheumatoid arthritis, antiphospholipids syndrome, bowel inflammation, and SLE. Here, we summarize the findings of recent investigations on TLR and DcR and their role in the immunopathogenesis of the SLE.
authors.affiliation: Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Università degli Studi di Palermo, DIBIMEF, Palermo, Italy.
authors.forename: Giuliana
authors.initials: G
authors.lastname: Guggino
authors.forename: Anna Rita
authors.initials: AR
authors.lastname: Giardina
authors.forename: Francesco
authors.initials: F
authors.lastname: Ciccia
authors.forename: Giovanni
authors.initials: G
authors.lastname: Triolo
authors.forename: Francesco
authors.initials: F
authors.lastname: Dieli
authors.forename: Guido
authors.initials: G
authors.lastname: Sireci
mesh_terms: D000818:Animals; D001324:Autoantigens / Q000276:immunology; D015551:Autoimmunity; D002450:Cell Communication; D018925:Chemokines / Q000276:immunology; D004195:Disease Models, Animal; D006801:Humans; D007113:Immunity, Innate; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D051379:Mice; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000276:immunology*; D053319:Tumor Necrosis Factor Decoy Receptors / Q000276:immunology*
chemical_list: D001324:Autoantigens; D018925:Chemokines; D051193:Toll-Like Receptors; D053319:Tumor Necrosis Factor Decoy Receptors