title: Fibroblast growth factor-23 and phosphorus metabolism.
abstract: The understanding of phosphorus metabolism has expanded considerably over the last decade. Recent studies have identified a novel bone-kidney endocrine axis that maintains phosphate homeostasis. When phosphate is in excess, FGF-23 is secreted from bone and acts on the kidney to promote phosphate excretion into urine and to suppress vitamin D synthesis, thereby inducing negative phosphate balance. This review summarizes the role of the FGF-23 axis on phosphorus metabolism, and presents the clinical entities that arise from activation or inactivation of the FGF-23 axis.
authors.affiliation: Pediatric Endocrinology, Meyer Children's Hospital, Rambam Medical Center, Rappaport Family Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
authors.forename: Dov
authors.initials: D
authors.lastname: Tiosano
mesh_terms: D000818:Animals; D053098:Familial Hypophosphatemic Rickets / Q000209:etiology / Q000235:genetics / Q000378:metabolism; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000150:complications / Q000235:genetics / Q000378:metabolism; D010011:Osteocytes / Q000378:metabolism / Q000502:physiology; D010758:Phosphorus / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D050608:Sodium-Phosphate Cotransporter Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology
chemical_list: C000717427:FGF23 protein, human; D050608:Sodium-Phosphate Cotransporter Proteins; D010758:Phosphorus; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23