title: An SNP within the angiotensin-converting enzyme distinguishes between sprint and distance performing Alaskan sled dogs in a candidate gene analysis.
abstract: The Alaskan sled dog offers a unique mechanism for studying the genetics of elite athletic performance. They are a group of mixed breed dogs, comprised of multiple common breeds, and a unique breed entity seen only as a part of the sled dog mix. Alaskan sled dogs are divided into 2 primary groups as determined by their racing skills. Distance dogs are capable of running over 1000 miles in 10 days, whereas sprint dogs run much shorter distances, approximately 30 miles, but in faster times, that is, 18-25 mph. Finding the genes that distinguish these 2 types of performers is likely to illuminate genetic contributors to human athletic performance. In this study, we tested for association between polymorphisms in 2 candidate genes; angiotensin-converting enzyme (ACE) and myostatin (MSTN) and enhanced speed and endurance performance in 174 Alaskan sled dogs. We observed 81 novel genetic variants within the ACE gene and 4 within the MSTN gene, including a polymorphism within the ACE gene that significantly (P value 2.38 × 10(-5)) distinguished the sprint versus distance populations.
authors.affiliation: Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Heather J
authors.initials: HJ
authors.lastname: Huson
authors.forename: Alexandra M
authors.initials: AM
authors.lastname: Byers
authors.forename: Jonathan
authors.initials: J
authors.lastname: Runstadler
authors.forename: Elaine A
authors.initials: EA
authors.lastname: Ostrander
mesh_terms: D000413:Alaska; D000818:Animals; D001483:Base Sequence; D004285:Dogs / Q000235:genetics*; D015810:Linkage Disequilibrium; D008969:Molecular Sequence Data; D055435:Myostatin / Q000235:genetics; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D010807:Physical Endurance / Q000235:genetics* / Q000502:physiology; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012420:Running / Q000502:physiology*; D017422:Sequence Analysis, DNA
chemical_list: D055435:Myostatin; D007703:Peptidyl-Dipeptidase A