title: Goblet cell carcinoid of the rectum with lymph node metastasis: report of a case.
abstract: We report an unusual case of goblet cell carcinoid (GCC) of the rectum. A 75-year-old man was admitted to our hospital with anal bleeding, and a hard tumor was felt on the anterior wall of the lower rectum during rectal examination. We performed colonoscopy, and found a 30-mm type 2 tumor in the lower rectum and anal canal. Histological examination of biopsies revealed rectal adenocarcinoma. Based on these findings, we diagnosed rectal adenocarcinoma and performed Miles' operation with lymph node dissection. Histological examination revealed an invasive lesion composed of signet-ring-like cells. Seven regional lymph node metastases were seen microscopically. The tumor produced copious mucin, which was stained with Alcian blue. Immunohistochemistry was positive for synaptophysin, chromogranin A, CD56, carcinoembryonic antigen, p53, Ki-67, E-cadherin, and cytokeratin 20. The final diagnosis was GCC of the rectum.
authors.affiliation: Department of Surgery, Kushiro Red Cross Hospital, 21-14 Shinei-cho, Kushiro, Hokkaido, 085-8512, Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Yamabuki
authors.forename: Makoto
authors.initials: M
authors.lastname: Omi
authors.forename: Atsuya
authors.initials: A
authors.lastname: Yonemori
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hayama
authors.forename: Soichi
authors.initials: S
authors.lastname: Murakami
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Inomata
authors.forename: Michio
authors.initials: M
authors.lastname: Mori
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Nihei
mesh_terms: D000368:Aged; D002276:Carcinoid Tumor / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009077:Mucins / Q000378:metabolism; D012004:Rectal Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D009077:Mucins