title: Vasogenic erectile dysfunction Topiramate-induced.
abstract: Reversible erectile dysfunction due to Topiramate has been linked to the effect of this antiepileptic drug on reproductive hormones levels. We described two epileptic male patients which experienced erectile dysfunction during Topiramate treatment. Serum sexual hormones were tested during treatment and at several time intervals following drug discontinuation. Topiramate did not seem to affect plasma levels of total, free and bioavailable testosterone and sex hormone-binding globulin. Since Topiramate erectile dysfunctions could not be related to changes in reproductive hormones levels, a vasogenic mechanism must be considered.
authors.affiliation: Department of Neurology, Università del Piemonte Orientale A. Avogadro, Novara, Italy. c civardi@yahoo.com
authors.forename: Carlo
authors.initials: C
authors.lastname: Civardi
authors.forename: Alessandra
authors.initials: A
authors.lastname: Collini
authors.forename: Paolo
authors.initials: P
authors.lastname: Gontero
authors.forename: Francesco
authors.initials: F
authors.lastname: Monaco
mesh_terms: D000328:Adult; D000728:Androgens / Q000097:blood; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D017029:Epilepsy, Complex Partial / Q000150:complications / Q000188:drug therapy; D004833:Epilepsy, Temporal Lobe / Q000150:complications / Q000188:drug therapy; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D018783:Impotence, Vasculogenic / Q000139:chemically induced* / Q000209:etiology; D007986:Luteinizing Hormone / Q000097:blood; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010413:Penis / Q000098:blood supply; D012039:Regional Blood Flow / Q000187:drug effects; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone / Q000097:blood; D000077236:Topiramate
chemical_list: D000728:Androgens; D000927:Anticonvulsants; D012739:Gonadal Steroid Hormones; D012738:Sex Hormone-Binding Globulin; D000077236:Topiramate; D005632:Fructose; D013739:Testosterone; D007986:Luteinizing Hormone