title: B7-H6/NKp30 interaction: a mechanism of alerting NK cells against tumors.
abstract: Natural killer (NK) cells are lymphocytes of the innate immune system that sense target cells through a panel of activating and inhibitory receptors. Together with NKG2D, the natural cytotoxicity receptors (NCRs) are major activating receptors involved in tumor cell detection. Although numerous NKG2D ligands have been identified, characterization of the molecules interacting with the NCRs is still incomplete. The identification of B7-H6 as a counter structure of the NCR NKp30 shed light on the molecular basis of NK cell immunosurveillance. We review here the current knowledge on NKp30 and B7-H6, and we discuss their potential role in anti-tumor immunity.
authors.affiliation: Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai Minato-ku, Tokyo, Japan.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Kaifu
authors.forename: Bertrand
authors.initials: B
authors.lastname: Escalière
authors.forename: Louis N
authors.initials: LN
authors.lastname: Gastinel
authors.forename: Eric
authors.initials: E
authors.lastname: Vivier
authors.forename: Myriam
authors.initials: M
authors.lastname: Baratin
mesh_terms: D060887:B7 Antigens / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism*; D015166:Monitoring, Immunologic; D055628:Natural Cytotoxicity Triggering Receptor 3 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism*; D025941:Protein Interaction Mapping
chemical_list: D060887:B7 Antigens; C431710:NCR3 protein, human; C542363:NCR3LG1 protein, human; D055628:Natural Cytotoxicity Triggering Receptor 3