title: The relationship between serum uric acid and spirometric values in participants in a health check: the Takahata study.
abstract: BACKGROUND
  Tissue hypoxia induces the degradation of adenosine triphosphate, resulting in the production of uric acid (UA). Patients with chronic obstructive pulmonary disease (COPD) have been reported to have high serum levels of UA (sUA), compared with control subjects. However, the relationship between sUA levels and spirometric measures has not been investigated in detail in a general population.
  
  
  METHODS
  Subjects aged 40 years or older (n = 2,917), who had participated in a community-based annual health check in Takahata, Japan, in 2004 and 2005, were enrolled in the study. These subjects performed spirometry, their blood pressure was measured, and a blood sample was taken.
  
  
  RESULTS
  sUA levels were significantly higher in males than in females. Percent predicted forced vital capacity [FVC %predicted] (r = -0.13) and forced expiratory volume in 1 s [FEV(1) %predicted] (r = -0.118) were inversely correlated with sUA levels in females but not in males. Univariate regression analysis indicated that age, body mass index (BMI), ethanol intake, mean blood pressure (BP), and serum creatinine (sCr) were significantly associated with sUA levels in males. In females, age, BMI, mean BP, hemoglobin A1c, sCr, FVC %predicted, and FEV(1) %predicted were significantly associated with sUA levels. Multiple linear regression analysis showed that for both genders, FVC %predicted and FEV(1) %predicted were predictive for sUA levels, independently of the other clinical parameters. Subjects with lung restriction had higher sUA levels than subjects without lung restriction. In addition, subjects with moderate and severe airflow limitation had higher sUA levels than subjects without airflow limitation or those with mild airflow limitation.
  
  
  CONCLUSIONS
  FVC %predicted and FEV(1) %predicted were significantly associated with sUA levels in a general population.
authors.affiliation: Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan.
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Aida
authors.forename: Yoko
authors.initials: Y
authors.lastname: Shibata
authors.forename: Daisuke
authors.initials: D
authors.lastname: Osaka
authors.forename: Shuichi
authors.initials: S
authors.lastname: Abe
authors.forename: Sumito
authors.initials: S
authors.lastname: Inoue
authors.forename: Koji
authors.initials: K
authors.lastname: Fukuzaki
authors.forename: Yoshikane
authors.initials: Y
authors.lastname: Tokairin
authors.forename: Akira
authors.initials: A
authors.lastname: Igarashi
authors.forename: Keiko
authors.initials: K
authors.lastname: Yamauchi
authors.forename: Takako
authors.initials: T
authors.lastname: Nemoto
authors.forename: Keiko
authors.initials: K
authors.lastname: Nunomiya
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kishi
authors.forename: Masamichi
authors.initials: M
authors.lastname: Sato
authors.forename: Tetsu
authors.initials: T
authors.lastname: Watanabe
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Konta
authors.forename: Sumio
authors.initials: S
authors.lastname: Kawata
authors.forename: Takeo
authors.initials: T
authors.lastname: Kato
authors.forename: Isao
authors.initials: I
authors.lastname: Kubota
mesh_terms: D000368:Aged; D015992:Body Mass Index; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007564:Japan; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012129:Respiratory Function Tests; D012737:Sex Factors; D013147:Spirometry; D014527:Uric Acid / Q000097:blood*; D014797:Vital Capacity / Q000502:physiology*
chemical_list: D014527:Uric Acid; D003404:Creatinine