title: Genome-based versus gene-based theory of cancer: possible implications for clinical practice.
abstract: The current state in oncology research indicates that the attempts to explain such complex process as cancerogenesis by a single or several genetic mutations were not successful enough. On the other hand, chromosomal/genomic instability--almost universal features of malignant tumours which influence a global pattern of gene expression and, subsequently, many oncogenic pathways--were often disregarded and considered nonessential to clinical application. However, a new arising field of system biology including 'new forms' of genome diversity such as copy number variations (CNV) and high-throughput oncogene mutation profiling now reveal all the complexity of cancer and provide the final explanation of the oncogenic pathways, based on stochastic (onco)genomic variation rather than on (onco)genic concepts.
authors.affiliation: Department of Experimental Oncology, Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia. todorovicn@ncrc.ac.rs
authors.forename: Natasa
authors.initials: N
authors.lastname: Todorovic-Rakovic
mesh_terms: D000782:Aneuploidy; D055028:Comparative Genomic Hybridization; D056915:DNA Copy Number Variations; D057890:Epigenomics; D018628:Gene Dosage; D015972:Gene Expression Regulation, Neoplastic; D015894:Genome, Human; D042822:Genomic Instability; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D049490:Systems Biology