title: Preparation and characterization of nano-hydroxyapatite/poly(vinyl alcohol) composite membranes for guided bone regeneration.
abstract: In this study, nano-hydroxyapatite/poly(vinyl alcohol) (n-HA/PVA) composite membranes were prepared by solvent casting and evaporation method. The morphology, mechanical properties, water absorption behavior, contact angle measurement and biocompatibility of these membranes were examined by SEM, FTIR, XRD, MTT assay and etc. The results demonstrate that the surface of composite membranes is suitable for the adhesion and proliferation of osteogenic cells, and that n-HA and PVA are in uniform distribution when the content of n-HA is less than 20 wt%. Tests of swelling behavior and water contact angle show that the incorporation of n-HA into PVA matrix significantly reduces its hydrophilicity. Mechanical tests reveal that the addition of n-HA nanoparticles reduces tensile strength and elongation rate but increases Young's modulus of composite membranes. Cell attachment test and MTT assay prove that n-HA/PVA composite membranes have good biocompatibility. Therefore, the n-HA/PVA composite membranes possess potential application for guided bone regeneration (GBR).
authors.affiliation: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, P R. China.
authors.forename: Shi
authors.initials: S
authors.lastname: Zeng
authors.forename: Shaozhi
authors.initials: S
authors.lastname: Fu
authors.forename: Gang
authors.initials: G
authors.lastname: Guo
authors.forename: Hang
authors.initials: H
authors.lastname: Liang
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Qian
authors.forename: Xiaohai
authors.initials: X
authors.lastname: Tang
authors.forename: Feng
authors.initials: F
authors.lastname: Luo
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D002448:Cell Adhesion; D002460:Cell Line; D049109:Cell Proliferation; D017886:Durapatite / Q000737:chemistry*; D055119:Elastic Modulus; D048091:Guided Tissue Regeneration / Q000379:methods*; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology; D010006:Osteoblasts / Q000166:cytology / Q000502:physiology; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D051381:Rats; D013718:Tensile Strength
chemical_list: D011142:Polyvinyl Alcohol; D017886:Durapatite