title: Kinetics of c-reactive protein (CRP) and serum amyloid A protein (SAA) in patients with community-acquired pneumonia (CAP), as presented with biologic half-life times.
abstract: Context: In management of community-acquired pneumonia (CAP), excellent biomarkers for inflammation would be helpful in our practice. Objectives: Kinetics of c-reactive protein (CRP) and serum amyloid A (SAA) was characterized, using their biologic half-life times. Materials and methods: Time course of CRP and SAA levels in the successfully treated 36 CAP patients were investigated and their half-life times were determined and compared. Results & Discussions: SAA and CRP declined in an exponential mean and the biologic half-life times of SAA levels was 34.9 ± 28.7 h, significantly shorter than that of CRP, 46.4 ± 21.7 h (p = 0.0014). Conclusion: The kinetic evidence, presented as biologic half-life times of CRP and SAA, helps us make a clinical assessment of CAP patients.
authors.affiliation: Department of Respiratory Medicine, Kyorin University School of Medicine , Mitaka, Tokyo , Japan.
authors.forename: Saori
authors.initials: S
authors.lastname: Takata
authors.forename: Hiroo
authors.initials: H
authors.lastname: Wada
authors.forename: Masaki
authors.initials: M
authors.lastname: Tamura
authors.forename: Takashi
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authors.lastname: Koide
authors.forename: Manabu
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authors.lastname: Higaki
authors.forename: Shin-Ichiro
authors.initials: SI
authors.lastname: Mikura
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Yasutake
authors.forename: Susumu
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authors.lastname: Hirao
authors.forename: Masuo
authors.initials: M
authors.lastname: Nakamura
authors.forename: Koujiro
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authors.lastname: Honda
authors.forename: Tomoko
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authors.lastname: Nagatomo
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Erei
authors.initials: E
authors.lastname: Sohara
authors.forename: Masato
authors.initials: M
authors.lastname: Watanabe
authors.forename: Takuma
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authors.lastname: Yokoyama
authors.forename: Takeshi
authors.initials: T
authors.lastname: Saraya
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kurai
authors.forename: Haruyuki
authors.initials: H
authors.lastname: Ishii
authors.forename: Hajime
authors.initials: H
authors.lastname: Goto