title: Self-reported adverse reactions in 4337 healthcare workers immunizations against novel H1N1 influenza.
abstract: OBJECTIVE
  The use of the 2009 H1N1 vaccine has generated much debate concerning safety issues among the general population and physicians. It was questioned if this is a safe vaccine. Therefore, we investigated the safety of an inactivated monovalent H1N1 pandemic influenza vaccine
  
  
  METHODS
  We focused on the H1N1 pandemic influenza vaccine Pandemrix® and applied a self reporting questionnaire in a population of healthcare workers (HCWs) and medical students at a major university hospital.
  
  
  RESULTS
  In total, 4337 individuals were vaccinated, consisting of 3808 HCWs and 529 medical students. The vaccination rate of the employees was higher than 40%. The majority of individuals were vaccinated in November 2009. In total, 291 of the 4337 vaccinations were reported to lead to one or more adverse reactions (6.7%). Local reactions were reported in 3.8%, myalgia and arthralgia in 3.7%, fatigue in 3.7%, headache in 3.1%.
  
  
  CONCLUSIONS
  Our data together with available data from several national and international institutions points to a safe pandemic influenza vaccine.
authors.affiliation: Institute of Occupational Medicine, Social Medicine and Environmental Medicine, Johann Wolfgang Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany. arbsozmed@uni-frankfurt.de.
authors.forename: Harald
authors.initials: H
authors.lastname: Bias
authors.forename: David
authors.initials: D
authors.lastname: Quarcoo
authors.forename: Claus
authors.initials: C
authors.lastname: Meier-Wronski
authors.forename: Sabine
authors.initials: S
authors.lastname: Wicker
authors.forename: Joachim
authors.initials: J
authors.lastname: Seybold
authors.forename: Albert
authors.initials: A
authors.lastname: Nienhaus
authors.forename: David A
authors.initials: DA
authors.lastname: Groneberg
authors.forename: Andres de
authors.initials: Ad
authors.lastname: Roux