title: Osteosarcoma of the jaw in children and young adults.
abstract: BACKGROUND
  Pediatric jaw osteosarcoma is uncommon, and data are scarce regarding clinical presentation, prognostic factors, and outcome.
  
  
  METHODS
  A single-institution medical record review from 1983 to 2008 for 12 patients age ≤ 21 years was undertaken for this study.
  
  
  RESULTS
  Median diagnosis age was 16.3 years (range, 6.3-21.9). Nine patients had mandible tumors. Osteoblastic subtype was most common (4 patients). Most tumors were large (ie, T2; n = 8) and high-grade (n = 8). Treatment characteristics were varied. Median follow-up was 27.1 months (range, 8-252 months). Five patients had tumor necrosis <80% after chemotherapy. No deaths were observed.
  
  
  CONCLUSIONS
  Jaw osteosarcoma outcome is better compared to extremity osteosarcoma, but further study is required regarding clinical prognostic factors.
authors.affiliation: Division of Pediatrics, Children's Cancer Hospital of The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. whuh@mdanderson.org
authors.forename: Winston W
authors.initials: WW
authors.lastname: Huh
authors.forename: F Christopher
authors.initials: FC
authors.lastname: Holsinger
authors.forename: Alejandro
authors.initials: A
authors.lastname: Levy
authors.forename: F Shana L
authors.initials: FS
authors.lastname: Palla
authors.forename: Peter M
authors.initials: PM
authors.lastname: Anderson
mesh_terms: D000293:Adolescent; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007573:Jaw Neoplasms / Q000473:pathology / Q000628:therapy*; D008297:Male; D060787:Neoplasm Grading; D012516:Osteosarcoma / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D016896:Treatment Outcome; D055815:Young Adult