title: IL28B polymorphism and the control of hepatitis C virus infection: ready for clinical use?
abstract: Polymorphisms in the region of the interleukin-28B (IL28B) gene have recently been associated with spontaneous and treatment induced clearance of hepatitis C virus infection. The specific mechanisms of how IL28B polymorphisms affect HCV suppression remain unknown. It is a matter of ongoing debate how to incorporate the IL28B data into the current treatment algorithms with pegylated interferon-alpha and ribavirin. The eventual role of the IL28B genotype in new therapeutic regimes with direct antiviral agents needs to be explored in the ongoing and future clinical studies with these agents.
authors.affiliation: Department of Gastroenterology and Hepatology, AZ St. Jan AV, Bruges, Belgium. Hans.Orlent@azbrugge.be
authors.forename: Hans
authors.initials: H
authors.lastname: Orlent
authors.forename: Hendrik
authors.initials: H
authors.lastname: Reynaert
authors.forename: Stefan
authors.initials: S
authors.lastname: Bourgeois
authors.forename: Vinciane
authors.initials: V
authors.lastname: Dideberg
authors.forename: Michael
authors.initials: M
authors.lastname: Adler
authors.forename: Isabelle
authors.initials: I
authors.lastname: Colle
authors.forename: Stéphane
authors.initials: S
authors.lastname: De Maeght
authors.forename: Wim
authors.initials: W
authors.lastname: Laleman
authors.forename: Peter
authors.initials: P
authors.lastname: Michielsen
authors.forename: Christophe
authors.initials: C
authors.lastname: Moreno
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Mulkay
authors.forename: Peter
authors.initials: P
authors.lastname: Stärkel
authors.forename: Jean
authors.initials: J
authors.lastname: Delwaide
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D004247:DNA / Q000235:genetics*; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics*; D006526:Hepatitis C / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007372:Interferons; D007378:Interleukins / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D000095022:Interferon Lambda
chemical_list: D000998:Antiviral Agents; D004247:DNA; D007372:Interferons; D007378:Interleukins; C000624353:interferon-lambda, human; D000095022:Interferon Lambda