title: Alkoxyamine-derived formamidines: configurational control and molecular folding.
abstract: N,N'-Disubstituted formamidines, and amidines in general, have very rich configurational, conformational, and tautomeric diversities. As part of an effort to incorporate alkoxyamine-derived formamidine units into foldamers, the first evidence for the isolation of the up-to-now unknown E isomer, the conditions for its exclusive formation, its stability and self-assembly properties, and its configurational isomerization to its much more common Z counterpart are reported. Considering the distinctly different H-bonding patterns displayed by both E and Z isomers, such configurational control may find applications in self-assembly, molecular recognition, and biomimetic systems.
authors.affiliation: Department of Chemistry, Queen's University, 90 Bader Lane, Kingston, Ontario K7L 3N6, Canada.
authors.forename: Weiwen
authors.initials: W
authors.lastname: Zhao
authors.forename: Ruiyao
authors.initials: R
authors.lastname: Wang
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Mosey
authors.forename: Anne
authors.initials: A
authors.lastname: Petitjean
mesh_terms: D000578:Amidines / Q000138:chemical synthesis*; D000588:Amines / Q000737:chemistry*; D007536:Isomerism; D007700:Kinetics; D008958:Models, Molecular; D008968:Molecular Conformation
chemical_list: D000578:Amidines; D000588:Amines; C077922:formamidine