title: Incidentally discovered osseous metaplasia within high-grade urothelial carcinoma of the bladder.
abstract: A 66-year-old male presented with gross hematuria and acute renal failure secondary to bilateral ureteral obstruction. Further work-up revealed muscle invasive urothelial carcinoma. Pathologic examination following radical cystoprostatectomy revealed high grade urothelial carcinoma with focal tumor-associated stromal osseous metaplasia. Reactive bone formation within urothelial carcinoma is a very rare clinical entity. Although typically benign, the presence of mature bone elements warrants thorough examination for sarcomatoid components.
authors.affiliation: Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. dudleyag@upmc.edu
authors.forename: Anne G
authors.initials: AG
authors.lastname: Dudley
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Tomaszewski
authors.forename: Amber H
authors.initials: AH
authors.lastname: Hughes
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Davies
mesh_terms: D000368:Aged; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D033162:Incidental Findings; D008297:Male; D008679:Metaplasia; D009361:Neoplasm Invasiveness; D014057:Tomography, X-Ray Computed; D014517:Ureteral Obstruction / Q000209:etiology; D001749:Urinary Bladder Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D019459:Urothelium / Q000473:pathology