title: Neuroprotective cadinane sesquiterpenes from the resinous exudates of Commiphora myrrha.
abstract: Three new cadinane sesquiterpenes, commiterpenes A-C, were isolated from the resinous exudates of Commiphora myrrha. Their structures and relative configurations were elucidated by spectroscopic methods (IR, ESIMS, HRESIMS, 1D and 2D NMR). All the isolated sesquiterpenes showed neuroprotective effects against MPP+-induced neuronal cell death in SH-SY5Y cells.
authors.affiliation: College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Yuanqiang
authors.initials: Y
authors.lastname: Guo
authors.forename: Peng
authors.initials: P
authors.lastname: Zhao
authors.forename: Chunfeng
authors.initials: C
authors.lastname: Xie
authors.forename: Da-qing
authors.initials: DQ
authors.lastname: Jin
authors.forename: Wenbin
authors.initials: W
authors.lastname: Hou
authors.forename: Tiejun
authors.initials: T
authors.lastname: Zhang
mesh_terms: D016923:Cell Death / Q000187:drug effects; D002460:Cell Line; D029744:Commiphora / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D009474:Neurons / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D053147:Plant Exudates / Q000737:chemistry / Q000494:pharmacology; D012116:Resins, Plant; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D018696:Neuroprotective Agents; D010936:Plant Extracts; D053147:Plant Exudates; D012116:Resins, Plant; D012717:Sesquiterpenes; C571573:commiterpene A; C571574:commiterpene B; C571575:commiterpene C