title: Alkaloids from Hippeastrum papilio.
abstract: Galanthamine, an acetylcholinesterase inhibitor marketed as a hydrobromide salt (Razadyne®, Reminyl®) for the treatment of Alzheimer's disease (AD), is obtained from Amaryllidaceae plants, especially those belonging to the genera Leucojum, Narcissus, Lycoris and Ungernia. The growing demand for galanthamine has prompted searches for new sources of this compound, as well as other bioactive alkaloids for the treatment of AD. In this paper we report the isolation of the new alkaloid 11β-hydroxygalanthamine, an epimer of the previously isolated alkaloid habranthine, which was identified using NMR techniques. It has been shown that 11β-hydroxygalanthamine has an important in vitro acetylcholinesterase inhibitory activity. Additionally, Hippeastrum papilio yielded substantial quantities of galanthamine.
authors.affiliation: Departament de Products Naturals, Biologia Vegetal i Edafologia, Facultat de Farmàcia, Universitat de Barcelona, Av. Joan XXIII s/n, E-08028 Barcelona, Spain.
authors.forename: Jean Paulo
authors.initials: JP
authors.lastname: de Andrade
authors.forename: Strahil
authors.initials: S
authors.lastname: Berkov
authors.forename: Francesc
authors.initials: F
authors.lastname: Viladomat
authors.forename: Carles
authors.initials: C
authors.lastname: Codina
authors.forename: José Angelo S
authors.initials: JA
authors.lastname: Zuanazzi
authors.forename: Jaume
authors.initials: J
authors.lastname: Bastida
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology; D000544:Alzheimer Disease / Q000188:drug therapy / Q000503:physiopathology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D002802:Cholinesterases / Q000378:metabolism*; D002855:Chromatography, Thin Layer; D005702:Galantamine / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D019668:Liliaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000032:analysis / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D000470:Alkaloids; D002800:Cholinesterase Inhibitors; D010936:Plant Extracts; D005702:Galantamine; D002802:Cholinesterases