title: Regulation of interleukin-10 and interleukin-22 expression in T helper cells.
abstract: Interleukin (IL)-10 and IL-22 are crucial regulators of inflammation during immune responses. While IL-10 functions to prevent excessive inflammation by acting on immune cells, IL-22 elicits innate responses from tissue epithelia and promotes wound healing. Although T helper (Th) cells are a major source for both cytokines, IL-10 and IL-22 are rarely co-expressed at high levels in the same cells. Here we discuss a number of common aspects as well as crucial differences in the molecular regulation of both cytokines that might explain their broad, but distinct expression among Th cell subsets.
authors.affiliation: Department of Immunology, Genentech, South San Francisco, CA 94080, USA. saschar@gene.com
authors.forename: Sascha
authors.initials: S
authors.lastname: Rutz
authors.forename: Wenjun
authors.initials: W
authors.lastname: Ouyang
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology; D007371:Interferon-gamma / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D016753:Interleukin-10 / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D007376:Interleukin-2 / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D007378:Interleukins / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D009928:Organ Specificity; D051880:Receptors, Notch / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D050791:STAT Transcription Factors / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D018417:Th1 Cells / Q000276:immunology* / Q000378:metabolism; D058504:Th17 Cells / Q000276:immunology* / Q000378:metabolism; D018418:Th2 Cells / Q000276:immunology* / Q000378:metabolism; D014945:Wound Healing / Q000276:immunology; D000097043:Interleukin-22
chemical_list: D007371:Interferon-gamma; D016753:Interleukin-10; D007376:Interleukin-2; D007378:Interleukins; D051880:Receptors, Notch; D050791:STAT Transcription Factors; D000097043:Interleukin-22