title: An MR comparison study of cardiogenic and noncardiogenic pulmonary edema in animal models.
abstract: OBJECTIVE
  To apply magnetic resonance (MR) imaging to differential diagnosis of cardiogenic pulmonary edema (CPE) and noncardiogenic pulmonary edema (NCPE).
  
  
  METHODS
  In the CPE group, MR measurements were performed on 5 rats just before and 3 h after administration of 21 ± 2% body weight of normal saline. In the NCPE group, measurements were similarly performed on 5 animals just before and 48 h after 0.75 mg/body of lipopolysaccharide intratracheal administration. Animals were killed for bronchoalveolar lavage fluid (BALF) or pathological analysis after MR measurements.
  
  
  RESULTS
  The relation between signal intensity and the T(2)* value of MR imaging was different in the two groups. The T(2)* in the NCPE group was significantly longer than that in the CPE group at the same signal intensity level. The lactate levels measured by in vivo MR spectroscopy did not show a difference between the CPE and NCPE groups, although the lactate BALF levels of the two groups were significantly different.
  
  
  CONCLUSIONS
  The relation between signal intensity and T(2)* value was useful for the differentiation between these two pulmonary diseases. The measurable lactate level in pulmonary lesions suggests the applicability of MR spectroscopy to pulmonary disease.
authors.affiliation: Biomedical MR Science Center, Shiga University of Medical Science, Shiga, Japan. fujisan@belle.shiga-med.ac.jp
authors.forename: Sakae
authors.initials: S
authors.lastname: Fujimoto
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Morikawa
authors.forename: Toshiro
authors.initials: T
authors.lastname: Inubushi
mesh_terms: D000818:Animals; D001992:Bronchoalveolar Lavage Fluid; D004195:Disease Models, Animal; D005260:Female; D006331:Heart Diseases / Q000175:diagnosis* / Q000473:pathology; D008070:Lipopolysaccharides / Q000378:metabolism; D008171:Lung Diseases / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D011654:Pulmonary Edema / Q000175:diagnosis* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D012128:Respiratory Distress Syndrome / Q000175:diagnosis / Q000473:pathology; D013997:Time Factors
chemical_list: D008070:Lipopolysaccharides