title: Bioactive dammarane-type saponins from Operculina turpethum.
abstract: Four new dammarane-type saponins, operculinosides A-D (1-4), were isolated from the aerial parts of Operculina turpethum, of which 1 and 2 are the first two dammarane-type triterpenoids having an oxymethyl group at C-24. Their structures were determined by spectroscopic analysis and acid hydrolysis. The absolute configuration of operculinoside A (1) was confirmed by X-ray crystallography. Compounds 1 and 3 showed significant protective activities against d-galactosamine-induced toxicity in L-02 human hepatic cells.
authors.affiliation: Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Xingke Road 723, Tianhe District, Guangzhou 510650, People's Republic of China.
authors.forename: Wenbing
authors.initials: W
authors.lastname: Ding
authors.forename: Fanli
authors.initials: F
authors.lastname: Zeng
authors.forename: Liangxiong
authors.initials: L
authors.lastname: Xu
authors.forename: Yunyun
authors.initials: Y
authors.lastname: Chen
authors.forename: Yifei
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Wei
mesh_terms: D027722:Convolvulaceae / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005688:Galactosamine / Q000633:toxicity; D022781:Hepatocytes / Q000187:drug effects; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000097669:Dammaranes
chemical_list: D004365:Drugs, Chinese Herbal; D005688:Galactosamine; D012503:Saponins; D014315:Triterpenes; D000097669:Dammaranes