title: Polyester polymer alloy as a high-performance membrane.
abstract: Polyester polymer alloy (PEPA) membrane is developed as a synthetic polymermembrane. It consists of two polymers - polyethersulfone (PES) and polyarylate (PAR).The pore size in membrane can be controlled by a blend ratio of PES and PAR. One unique characteristic is that PEPA membrane has three layers of a skin layer on the inner surface, a porous layer in the membrane, and a skin layer on the outer surface, respectively. The permeability of water and substances is controlled by the skin layer on the inner surface. PEPA membrane dialyzer can be adequately considered as a high-performance dialyzer. Furthermore, the skin layer on the outer surface can block endotoxin from the dialysis fluid side. PEPA membrane can therefore be used as an endotoxin-retentive filter. The other unique characteristic is that each amount of albumin loss or β2-microglobulin removal can be controlled by an additive amount of polyvinylpyrrolidone. This means that the PEPA dialyzer can be clinically used to meet the conditions of the patient.
authors.forename: Tadaaki
authors.initials: T
authors.lastname: Igoshi
authors.forename: Narumi
authors.initials: N
authors.lastname: Tomisawa
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Hori
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Jinbo
mesh_terms: D000327:Adsorption; D001672:Biocompatible Materials; D001798:Blood Proteins / Q000378:metabolism; D004058:Diffusion; D004731:Endotoxins / Q000097:blood; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008422:Materials Testing; D008567:Membranes, Artificial; D015394:Molecular Structure; D008970:Molecular Weight; D010539:Permeability; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry; D011205:Povidone; D006435:Renal Dialysis / Q000295:instrumentation*; D012709:Serum Albumin / Q000378:metabolism; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000138:chemical synthesis / Q000737:chemistry; D016896:Treatment Outcome; D014511:Uremia / Q000378:metabolism / Q000628:therapy; D001613:beta 2-Microglobulin / Q000097:blood
chemical_list: D001672:Biocompatible Materials; D001798:Blood Proteins; D004731:Endotoxins; D008567:Membranes, Artificial; D011091:Polyesters; D011108:Polymers; D012709:Serum Albumin; D013450:Sulfones; D001613:beta 2-Microglobulin; C022840:polyether sulfone; D011205:Povidone