title: Posterior reversible encephalopathy syndrome complicating intracranial hemorrhage after phenylpropanolamine exposure.
abstract: A 57-year-old woman suffered sudden onset of thunderclap headache after exposure to phenylpropanolamine (PPA), and subsequently developed posterior reversible encephalopathy syndrome (PRES) complicated by occipital intracranial hemorrhage (ICH) with cerebral vasoconstriction. PPA is well known to be associated with ICH and vasoconstriction, but this case illustrates the association with PRES. The danger of exposure to PPA and subsequent adverse events is quite low at present, but we must consider the possibility of exposure to medical agents in patients with repeated severe headache who have no organic disorder.
authors.affiliation: Department of Neurology, Juntendo University Urayasu Hospital, Urayasu, Chiba, Japan.
authors.forename: Tadaaki
authors.initials: T
authors.lastname: Kawanabe
authors.forename: Ryota
authors.initials: R
authors.lastname: Tanaka
authors.forename: Yohei
authors.initials: Y
authors.lastname: Sakaguchi
authors.forename: Osamu
authors.initials: O
authors.lastname: Akiyama
authors.forename: Hideki
authors.initials: H
authors.lastname: Shimura
authors.forename: Yukimasa
authors.initials: Y
authors.lastname: Yasumoto
authors.forename: Masanori
authors.initials: M
authors.lastname: Ito
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Hattori
authors.forename: Shigeki
authors.initials: S
authors.lastname: Tanaka
mesh_terms: D002543:Cerebral Hemorrhage / Q000139:chemically induced* / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000009:adverse effects; D010665:Phenylpropanolamine / Q000009:adverse effects*; D020769:Posterior Cerebral Artery / Q000187:drug effects / Q000473:pathology; D054038:Posterior Leukoencephalopathy Syndrome / Q000139:chemically induced* / Q000150:complications / Q000473:pathology; D013566:Sympathomimetics / Q000009:adverse effects*
chemical_list: D009883:Ophthalmic Solutions; D013566:Sympathomimetics; D010665:Phenylpropanolamine