title: Prognostic value of proliferating cell nuclear antigen in parotid gland cancer.
abstract: Although cell proliferation is related to tumour aggressiveness and prognosis, there are few studies describing the expression of proliferative markers in salivary gland cancer. Our aim was to assess the long-term prognostic value of the proliferating cell nuclear antigen (PCNA) in a large group of histologically different salivary gland cancers. We analysed the expression of PCNA in 159 patients with parotid gland cancer by means of immunohistochemistry. The mean follow-up time was 56.6 months. A high expression of PCNA showed a significant correlation to the patients' pathological lymph node stage (p = 0.004). A high PCNA expression significantly indicated a poor 5-year disease-free (p = 0.046) and overall survival rate (p = 0.018). The PCNA expression was the only prognostic factor for a worse 5-year disease-free and overall survival in acinic cell carcinomas (p = 0.004, p = 0.022). The correlation between PCNA expression and survival probabilities of salivary gland cancer might make proliferation markers helpful tools in patient follow-up, prognosis and targeted therapy in salivary gland cancer in future.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Cologne, Kerpener Strasse 62, 50937 Cologne, Germany. markus.stenner@uk-koeln.de
authors.forename: Markus
authors.initials: M
authors.lastname: Stenner
authors.forename: Ariane
authors.initials: A
authors.lastname: Demgensky
authors.forename: Christoph
authors.initials: C
authors.lastname: Molls
authors.forename: Aline
authors.initials: A
authors.lastname: Hardt
authors.forename: Jan C
authors.initials: JC
authors.lastname: Luers
authors.forename: Maria
authors.initials: M
authors.lastname: Grosheva
authors.forename: Christian U
authors.initials: CU
authors.lastname: Huebbers
authors.forename: Jens P
authors.initials: JP
authors.lastname: Klussmann
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D018267:Carcinoma, Acinar Cell / Q000378:metabolism* / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010306:Parotid Gland / Q000737:chemistry* / Q000473:pathology; D010307:Parotid Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000401:mortality; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis*; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D018809:Proliferating Cell Nuclear Antigen