title: Magnetic bioactive glass ceramic in the system CaO-P2O5-SiO2-MgO-CaF2-MnO2-Fe2O3 for hyperthermia treatment of bone tumor.
abstract: Magnetic bioactive glass ceramic (MG) in the system CaO-SiO(2)-P(2)O(5)-MgO-CaF(2)-MnO(2)-Fe(2)O(3) for hyperthermia treatment of bone tumor was synthesized. The phase composition was investigated by XRD. The magnetic property was measured by VSM. The in vitro bioactivity was investigated by simulated body fluid (SBF) soaking experiment. Cell growth on the surface of the material was evaluated by co-culturing osteoblast-like ROS17/2.8 cells with materials for 7 days. The results showed that MG contained CaSiO(3) and Ca(5)(PO(4))(3)F as the main phases, and MnFe(2)O(4) and Fe(3)O(4) as the magnetic phases. Under a magnetic field of 10,000 Oe, the saturation magnetization and coercive force of MG were 6.4 emu/g and 198 Oe, respectively. After soaking in SBF for 14 days, hydroxyapatite containing CO(3)(2-) was observed on the surface of MG. The experiment of co-culturing cells with material showed that cells could successfully attach and well proliferate on MG.
authors.affiliation: College of Medical Technology and Engineering, Henan University of Science and Technology, Luo Yang, 471003, Henan, People's Republic of China. scdxlgd@yahoo.cn
authors.forename: Guangda
authors.initials: G
authors.lastname: Li
authors.forename: Shuying
authors.initials: S
authors.lastname: Feng
authors.forename: Dali
authors.initials: D
authors.lastname: Zhou
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001859:Bone Neoplasms / Q000628:therapy*; D002118:Calcium / Q000737:chemistry; D018929:Cell Culture Techniques; D045744:Cell Line, Tumor; D002516:Ceramics / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry; D005898:Glass / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D006979:Hyperthermia, Induced; D007287:Inorganic Chemicals / Q000737:chemistry*; D008280:Magnetics; D017895:Manganese Compounds / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D010006:Osteoblasts; D010087:Oxides / Q000737:chemistry; D013997:Time Factors; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D005290:Ferric Compounds; D007287:Inorganic Chemicals; D017895:Manganese Compounds; D010087:Oxides; C000499:ferric oxide; C027424:manganese oxide; C023506:Glass ceramics; D002118:Calcium