title: Serum intestinal fatty acid binding protein and phosphate levels in the diagnosis of acute intestinal ischemia: an experimental study in rabbits.
abstract: BACKGROUND
  Acute intestinal ischemia is a serious clinical disorder with mesenteric infarction, which has high mortality. It is important to establish a biochemical marker for the early diagnosis of acute intestinal ischemia.
  
  
  OBJECTIVE
  The aim of this experimental study was to assess the changes in the serum levels of intestinal fatty acid binding protein (IFABP) and phosphate by time using the acute intestinal ischemia model in rabbits.
  
  
  METHODS
  In this study, 21 New Zealand rabbits were randomly divided into three groups. Blood samples were obtained at 0, 1, 3, and 6 h in the control group. Blood samples were obtained at 0, 1, 3, and 6 h in the sham group after simple laparotomy. Blood samples were obtained at the same hours in the ischemia group after simple laparotomy and ligation of the superior mesenteric artery.
  
  
  RESULTS
  There was no significant difference between the control, the sham, and the ischemia groups in terms of serum IFABP levels at any time (p > 0.05). Serum phosphate levels significantly increased in the ischemia group (p < 0.001). Studies on IFABP have begun emerging in the literature, and there is no standard approach for the technique to measure the IFABP level. No studies on IFABP were found in the literature on rabbits.
  
  
  CONCLUSIONS
  Based on our results, the role that IFABP levels play in the diagnosis of acute intestinal ischemia is unclear at this time. Serum phosphate levels continued to rise as the duration of ischemia was prolonged. These findings support the suggestion that serum phosphate levels are valuable for the diagnosis of acute intestinal ischemia.
authors.affiliation: Department of Emergency Medicine, Konya Training and Research Hospital, Konya, Turkey.
authors.forename: Zerrin Defne
authors.initials: ZD
authors.lastname: Dundar
authors.forename: Basar
authors.initials: B
authors.lastname: Cander
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gul
authors.forename: Keziban Ucar
authors.initials: KU
authors.lastname: Karabulut
authors.forename: Sedat
authors.initials: S
authors.lastname: Kocak
authors.forename: Sadik
authors.initials: S
authors.lastname: Girisgin
authors.forename: Idris
authors.initials: I
authors.lastname: Mehmetoglu
authors.forename: Hatice
authors.initials: H
authors.lastname: Toy
mesh_terms: D000208:Acute Disease; D000818:Animals; D015415:Biomarkers / Q000097:blood; D004195:Disease Models, Animal; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D007511:Ischemia / Q000175:diagnosis*; D008641:Mesenteric Vascular Occlusion / Q000097:blood*; D010710:Phosphates / Q000097:blood*; D011817:Rabbits
chemical_list: D015415:Biomarkers; D050556:Fatty Acid-Binding Proteins; D010710:Phosphates