title: [Robo1 expression in breast cancer and its relationship to brain metastasis].
abstract: OBJECTIVE
  To detect the expression of Robo1 in different breast tumors and its association with the breast cancer brain metastasis.
  
  
  METHODS
  Labelled streptavidin-biotin (LSAB) staining was used to examine the Robo1 expression in specimens from 24 cases of invasive ductal carcinoma (IDC) with brain metastasis, 71 cases of IDC without brain metastasis, 22 cases of ductal carcinoma in situ (DCIS) and 23 cases of fibroadenoma.
  
  
  RESULTS
  The expression pattern of Robo1 in DCIS (59.1%) and IDC (45.3%) was significantly lower than that in adenofibroma (87.0%, P < 0.05). The expression of Robo1 in IDC with brain metastasis (12.5%) was significantly lower than that in IDC without brain metastasis (56.3%, P < 0.05). The expression of Robo1 was much higher in more than 50 year-old-group (57.8%) than that in less than 50 year-old-group (34.0%) of IDC patients. The overall survival time in patients with the Robo1 negative expression was significantly shorter than those with positive expression (P < 0.05). No correlation was found between the Robo1 expression and the tumor size, lymph node metastasis, pathologic stage, histological grade and clinical stage (P > 0.05).
  
  
  CONCLUSIONS
  The Robo1 expression correlates negatively with IDC brain metastasis, and correlates positively with the age and prognosis of IDC patients. Robo1 may be applied as a marker in evaluation of the IDC prognosis and brain metastasis.
authors.affiliation: Central Laborarory, Tianjin Medical University Cancer Institute and Hospital, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Le
authors.initials: L
authors.lastname: Wang
authors.forename: Fang-fang
authors.initials: FF
authors.lastname: Liu
authors.forename: Yong-jie
authors.initials: YJ
authors.lastname: Ma
authors.forename: Li
authors.initials: L
authors.lastname: Fu
authors.forename: Wen-liang
authors.initials: WL
authors.lastname: Li
authors.forename: Feng
authors.initials: F
authors.lastname: Gu
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001932:Brain Neoplasms / Q000556:secondary*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000556:secondary / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000378:metabolism / Q000556:secondary / Q000601:surgery; D005260:Female; D018226:Fibroadenoma / Q000378:metabolism; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000378:metabolism*; D015996:Survival Rate; D000097905:Roundabout Proteins
chemical_list: D009419:Nerve Tissue Proteins; D011971:Receptors, Immunologic; D000097905:Roundabout Proteins