title: Design and synthesis of a novel triptycene-based ligand for modeling carboxylate-bridged diiron enzyme active sites.
abstract: A novel triptycene-based ligand with a preorganized framework was designed to model carboxylate-bridged diiron active sites in bacterial multicomponent monooxygenase (BMM) hydroxylase enzymes. The synthesis of the bis(benzoxazole)-appended ligand L1 depicted was accomplished in 11 steps. Reaction of L1 with iron(II) triflate and a carboxylate source afforded the desired diiron(II) complex [Fe(2)L1(μ-OH)(μ-O(2)CAr(Tol))(OTf)(2)].
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Rui
authors.initials: R
authors.lastname: Cao
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Lippard
mesh_terms: D000873:Anthracenes / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D020134:Catalytic Domain; D018360:Crystallography, X-Ray; D007501:Iron / Q000737:chemistry* / Q000378:metabolism; D008024:Ligands; D010105:Oxygenases / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000873:Anthracenes; D002264:Carboxylic Acids; D008024:Ligands; C520712:triptycene; D007501:Iron; D010105:Oxygenases; C021555:methane monooxygenase