title: Effects of photoacoustic imaging and photothermal ablation therapy mediated by targeted hollow gold nanospheres in an orthotopic mouse xenograft model of glioma.
abstract: Advancements in nanotechnology have made it possible to create multifunctional nanostructures that can be used simultaneously to image and treat cancers. For example, hollow gold nanospheres (HAuNS) have been shown to generate intense photoacoustic signals and induce efficient photothermal ablation (PTA) therapy. In this study, we used photoacoustic tomography, a hybrid imaging modality, to assess the intravenous delivery of HAuNS targeted to integrins that are overexpressed in both glioma and angiogenic blood vessels in a mouse model of glioma. Mice were then treated with near-infrared laser, which elevated tumor temperature by 20.7°C. We found that PTA treatment significantly prolonged the survival of tumor-bearing mice. Taken together, these results show the feasibility of using a single nanostructure for image-guided local tumor PTA therapy with photoacoustic molecular imaging.
authors.affiliation: Department of Experimental Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.forename: Marites P
authors.initials: MP
authors.lastname: Melancon
authors.forename: Chiyi
authors.initials: C
authors.lastname: Xiong
authors.forename: Qian
authors.initials: Q
authors.lastname: Huang
authors.forename: Andrew
authors.initials: A
authors.lastname: Elliott
authors.forename: Shaoli
authors.initials: S
authors.lastname: Song
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.forename: Leo G
authors.initials: LG
authors.lastname: Flores
authors.forename: Juri G
authors.initials: JG
authors.lastname: Gelovani
authors.forename: Lihong V
authors.initials: LV
authors.lastname: Wang
authors.forename: Geng
authors.initials: G
authors.lastname: Ku
authors.forename: R Jason
authors.initials: RJ
authors.lastname: Stafford
authors.forename: Chun
authors.initials: C
authors.lastname: Li
mesh_terms: D055011:Ablation Techniques / Q000379:methods*; D000818:Animals; D003952:Diagnostic Imaging / Q000379:methods*; D005910:Glioma / Q000473:pathology / Q000628:therapy*; D006046:Gold; D006801:Humans; D051379:Mice; D054118:Nanospheres; D009368:Neoplasm Transplantation; D010789:Phototherapy / Q000379:methods
chemical_list: D006046:Gold