title: Dielectric response of particles in flowing media: the effect of shear-induced rotation on the variation in particle polarizability.
abstract: When particles in liquid suspensions flow through channels and pipes in a laminar fashion, the resulting parabolic velocity profile gives rise to shear, which induces the particles to rotate. If flowing suspensions containing dielectric particles are immersed in an external electric field, the anisotropic polarization induced in rotating nonspherical particles will vary with the orientation of the particle with respect to the external field; what results is an uncertainty in experimental measurements that involve particle polarization. The present study establishes the limits of this uncertainty and shows that departure from spherical symmetry in individual particles can lead to a significant overlap in measurements attempting to discriminate between particle subpopulations in suspensions. For example, the uncertainty in signal amplitude for a population of activated T-lymphocytes can be as high as 20%. Such concerns arise in applications like field-flow fractionation, dielectrophoretic sorting of particles, flow impedance measurements and cytometry, and, most recently, isodielectric separation, all of which are used to separate particles in a flow based on their dielectric response. This paper considers axisymmetric particles as the first departure from the approximation of spherical symmetry, shows how to calculate an estimate of the size of the population overlap, and suggests possible strategies to minimize it.
authors.affiliation: Department of Electrical and Computer Engineering, University of Manitoba, E2-390 EITC, 75A Chancelor Circle, Winnipeg, Manitoba, Canada R3T 5V6.
authors.forename: Marija
authors.initials: M
authors.lastname: Nikolic-Jaric
authors.forename: Graham A
authors.initials: GA
authors.lastname: Ferrier
authors.forename: Douglas J
authors.initials: DJ
authors.lastname: Thomson
authors.forename: Greg E
authors.initials: GE
authors.lastname: Bridges
authors.forename: Mark R
authors.initials: MR
authors.lastname: Freeman
mesh_terms: D000465:Algorithms; D000818:Animals; D016880:Anisotropy; D001703:Biophysics / Q000379:methods*; D004566:Electrodes; D004574:Electromagnetic Fields; D006801:Humans; D007368:Interferometry / Q000379:methods; D044085:Microfluidics; D015233:Models, Statistical; D010316:Particle Size; D012399:Rotation; D033081:Shear Strength; D013314:Stress, Mechanical; D013601:T-Lymphocytes / Q000166:cytology* / Q000473:pathology