title: Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery.
abstract: OBJECTIVE
  To assess the effect of intravenous tranexamic acid on blood loss during and after cesarean delivery.
  
  
  METHODS
  One hundred pregnant women were randomized to receive either 10 mg/kg of tranexamic acid or placebo intravenously 20 minutes before incision in a double-blind controlled study. Postplacental delivery blood loss, postoperative hemorrhage 2 hours after surgery, and oxytocin administration were recorded.
  
  
  RESULTS
  The patients' mean age, weight, and duration of surgery were similar between the 2 groups. Mean blood loss was significantly less in the tranexamic acid group compared with the control group for both intraoperative bleeding (262.5 ± 39.6 vs 404.7 ± 94.4 mL) and postoperative bleeding (67.1 ± 6.5 vs 141.0 ± 33.9 mL; P<0.001), respectively. Oxytocin administration was significantly less in the tranexamic acid group compared with the control group (39 ± 5.8 vs 43 ± 5.4 units; P=0.001).
  
  
  CONCLUSIONS
  Intravenous tranexamic acid decreased intra- and postoperative blood loss and oxytocin administered in patients delivered by cesarean.
authors.affiliation: Anesthesia and Analgesia Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Movafegh
authors.forename: Laleh
authors.initials: L
authors.lastname: Eslamian
authors.forename: Azita
authors.initials: A
authors.lastname: Dorabadi
mesh_terms: D000328:Adult; D000933:Antifibrinolytic Agents / Q000627:therapeutic use*; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D002585:Cesarean Section / Q000009:adverse effects / Q000379:methods; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D010120:Oxytocics / Q000008:administration & dosage; D010121:Oxytocin / Q000008:administration & dosage; D006473:Postpartum Hemorrhage / Q000209:etiology / Q000517:prevention & control; D014148:Tranexamic Acid / Q000627:therapeutic use*; D014592:Uterine Hemorrhage / Q000209:etiology / Q000517:prevention & control*; D055815:Young Adult
chemical_list: D000933:Antifibrinolytic Agents; D010120:Oxytocics; D010121:Oxytocin; D014148:Tranexamic Acid