title: Increased frequency of first-episode poststroke depression after discontinuation of escitalopram.
abstract: OBJECTIVE
  The purpose of this study was to compare escitalopram, problem-solving therapy, and placebo to prevent poststroke depression during 6 months after discontinuation of treatment.
  
  
  METHODS
  We examined for depression 33 patients assigned to placebo, 34 to escitalopram, and 41 to problem-solving therapy.
  
  
  RESULTS
  After controlling for age, gender, prior mood disorder, and severity of stroke, new-onset major depression and Hamilton Depression scores were significantly higher 6 months after escitalopram was discontinued compared with the problem-solving therapy or placebo groups.
  
  
  CONCLUSIONS
  Discontinuation of escitalopram may increase poststroke depressive symptoms.
authors.affiliation: Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA. robert-robinson@uiowa.edu
authors.forename: Katsunaka
authors.initials: K
authors.lastname: Mikami
authors.forename: Ricardo E
authors.initials: RE
authors.lastname: Jorge
authors.forename: David J
authors.initials: DJ
authors.lastname: Moser
authors.forename: Stephan
authors.initials: S
authors.lastname: Arndt
authors.forename: Mijin
authors.initials: M
authors.lastname: Jang
authors.forename: Ana
authors.initials: A
authors.lastname: Solodkin
authors.forename: Steven L
authors.initials: SL
authors.lastname: Small
authors.forename: Pasquale
authors.initials: P
authors.lastname: Fonzetti
authors.forename: Mark T
authors.initials: MT
authors.lastname: Hegel
authors.forename: Robert G
authors.initials: RG
authors.lastname: Robinson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015283:Citalopram / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000453:epidemiology / Q000523:psychology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000188:drug therapy* / Q000453:epidemiology / Q000523:psychology*; D016896:Treatment Outcome
chemical_list: D015283:Citalopram