title: [In vitro evaluation of the gels properties prepared on Pluronic F-127 as vehicles for administration prolactin by injection].
abstract: The aim of this study was to prepare a thermoresponsive formulations, which are a carrier for proteins--prolactin administered directly into solid tumor and which obtain sol-gel transitions at physiological ranges of temperature. Prolactin (PRL) is a hormone that in vivo and in vitro exhibits antiangiogenic properties. Application of this protein in the proposed formulations can be particularly advantageous because of its relatively low stability and limited ability to transmembrane penetration. The paper prepared thermoresponsive carriers, based on nonionic polymer Pluronic F-127 with selected excipients such as dextran 7000, PEG 400, Tween 20 and Tween 80. The sol-gel transition temperature of the formulations was investigated and their physicochemical properties such as pH, density, osmotic pressure were studied. In the remainder of the work carried out tests of prolactin release from the proposed media. The results obtained indicate that a significant influence on the theological parameters obtained carriers and the availability of pharmaceutical composition of prolactin was developed formulation.
authors.affiliation: Katedra i Zakład Technologii Postaci Leku Akademii Medycznej we Wrocławiu. bozkar@ktpl.am.wroc.pl
authors.forename: Bozena
authors.initials: B
authors.lastname: Karolewicz
authors.forename: Anna
authors.initials: A
authors.lastname: Pawlik-Gałczyńska
authors.forename: Janusz
authors.initials: J
authors.lastname: Pluta
authors.forename: Florian
authors.initials: F
authors.lastname: Ryszka
mesh_terms: D020533:Angiogenesis Inhibitors / Q000008:administration & dosage* / Q000737:chemistry; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D005079:Excipients / Q000008:administration & dosage / Q000737:chemistry; D005782:Gels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D015552:Injections, Intralesional; D014677:Pharmaceutical Vehicles / Q000737:chemistry*; D020442:Poloxamer / Q000737:chemistry*; D011388:Prolactin / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D012212:Rheology
chemical_list: D020533:Angiogenesis Inhibitors; D005079:Excipients; D005782:Gels; D014677:Pharmaceutical Vehicles; D020442:Poloxamer; D011388:Prolactin