title: Platelet vesicular monoamine transporter 2 density in the disruptive behavior disorders.
abstract: In a former study, we reported decreased platelet vesicular monoamine transporter 2 (VMAT2) density (Bmax) in patients with ADHD. The current study aimed at measuring platelet VMAT2 in the disruptive behavior disorders (DBDs) to assess whether this finding is specific to ADHD or generalizable to the broader DBD concept. The study included 13 patients with DBDs aged 10-12 years and 16 healthy volunteers aged 8-17 years. All participants underwent a thorough clinical evaluation using Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version for diagnosis, the Nisonger Child Behavior Rating Form, the Clinical Global Impressions Scale-Severity version, and the DSM-IV ADHD Scale (DAS). The study group's DAS scores did not differ from those of the control group. There was no significant difference between the patients with DBDs and the control group either in VMAT2 density (Bmax) or affinity (Kd) as measured by high-affinity [(3)H]TBZOH binding. We conclude that the formerly reported decreased platelet VMAT2 Bmax in patients with ADHD may be specific to ADHD and not present in DBDs. Larger-scale replication is needed.
authors.affiliation: Geha Mental Health Center, Petach Tiqva, Israel. zalsman@post.tau.ac.il
authors.forename: Gil
authors.initials: G
authors.lastname: Zalsman
authors.forename: Dorit
authors.initials: D
authors.lastname: Aslanov-Farbstein
authors.forename: Moshe
authors.initials: M
authors.lastname: Rehavi
authors.forename: Netta
authors.initials: N
authors.lastname: Roz
authors.forename: Robert
authors.initials: R
authors.lastname: Vermeiren
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Laor
authors.forename: Abraham
authors.initials: A
authors.lastname: Weizman
authors.forename: Paz
authors.initials: P
authors.lastname: Toren
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000453:epidemiology* / Q000378:metabolism*; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000453:epidemiology* / Q000378:metabolism*; D001792:Blood Platelets / Q000378:metabolism; D002648:Child; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D011869:Radioligand Assay; D013747:Tetrabenazine / Q000031:analogs & derivatives; D050493:Vesicular Monoamine Transport Proteins / Q000097:blood* / Q000378:metabolism
chemical_list: D050493:Vesicular Monoamine Transport Proteins; C032811:dihydrotetrabenazine; D013747:Tetrabenazine