title: Getting physical to fix pharma.
abstract: Powerful technologies allow the synthesis and testing of large numbers of new compounds, but the failure rate of pharmaceutical R&D remains very high. Greater understanding of the fundamental physical chemical behaviour of molecules could be the key to greatly enhancing the success rate of drug discovery.
authors.forename: Patrick R
authors.initials: PR
authors.lastname: Connelly
authors.forename: T Minh
authors.initials: TM
authors.lastname: Vuong
authors.forename: Mark A
authors.initials: MA
authors.lastname: Murcko
mesh_terms: D055598:Chemical Phenomena; D055808:Drug Discovery / Q000379:methods*; D004345:Drug Industry / Q000379:methods; D008024:Ligands; D008958:Models, Molecular; D004364:Pharmaceutical Preparations / Q000737:chemistry* / Q000378:metabolism; D011487:Protein Conformation; D012106:Research
chemical_list: D008024:Ligands; D004364:Pharmaceutical Preparations