title: Gastric tumours in hereditary cancer syndromes: clinical features, molecular biology and strategies for prevention.
abstract: Gastric cancer is the major cause of cancer-related deaths worldwide. The majority of them are classified as sporadic, whereas the remaining 10% exhibit familial clustering. Hereditary diffuse gastric cancer (HDGC) syndrome is the most important condition that leads to hereditary gastric cancer. However, other hereditary cancer syndromes, such as hereditary non-polyposis colorectal cancer, familial adenomatous polyposis, Peutz-Jeghers syndrome, Li-Fraumeni syndrome and hereditary breast and ovarian cancer, entail a higher risk compared to the general population for developing this kind of neoplasia. In this review, we describe briefly the most important aspects related to clinical features, molecular biology and strategies for prevention in hereditary gastric associated to different cancer syndromes.
authors.affiliation: Medical Oncology Department, Infanta Sofía University Hospital, San Sebastián de los Reyes, Madrid, Spain. mariasereno75@mail.com
authors.forename: María
authors.initials: M
authors.lastname: Sereno
authors.forename: Cristina
authors.initials: C
authors.lastname: Aguayo
authors.forename: Carmen
authors.initials: C
authors.lastname: Guillén Ponce
authors.forename: César
authors.initials: C
authors.lastname: Gómez-Raposo
authors.forename: Francisco
authors.initials: F
authors.lastname: Zambrana
authors.forename: Miriam
authors.initials: M
authors.lastname: Gómez-López
authors.forename: Enrique
authors.initials: E
authors.lastname: Casado
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000235:genetics / Q000473:pathology / Q000628:therapy; D002277:Carcinoma / Q000175:diagnosis / Q000235:genetics / Q000473:pathology / Q000517:prevention & control; D005817:Genetic Counseling / Q000379:methods; D020022:Genetic Predisposition to Disease; D006801:Humans; D008954:Models, Biological; D008967:Molecular Biology / Q000379:methods; D009386:Neoplastic Syndromes, Hereditary / Q000175:diagnosis / Q000235:genetics / Q000473:pathology / Q000517:prevention & control; D011315:Preventive Medicine / Q000379:methods*; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000473:pathology / Q000517:prevention & control