title: Dehydration of detomidine hydrochloride monohydrate.
abstract: The thermodynamic stability of detomidine hydrochloride monohydrate has been evaluated on the basis of phase transition kinetics in solid state. A method free of empirical models was used for the treatment of kinetic data, and compared to several known solid state kinetic data processing methods. Phase transitions were monitored by powder X-ray diffraction (PXRD) and thermal analysis. Full PXRD profiles were used for determining the phase content instead of single reflex intensity measurements, in order to minimize the influence of particle texture. We compared the applicability of isothermal and nonisothermal methods to our investigation of detomidine hydrochlorine monohydrate dehydration.
authors.affiliation: University of Latvia, Department of Chemistry, Rīga, Latvia. kaspars.veldre@inbox.lv
authors.forename: K
authors.initials: K
authors.lastname: Veldre
authors.forename: A
authors.initials: A
authors.lastname: Actiņš
authors.forename: J
authors.initials: J
authors.lastname: Jaunbergs
mesh_terms: D058647:Adrenergic alpha-2 Receptor Agonists / Q000737:chemistry*; D003890:Desiccation; D004055:Differential Thermal Analysis; D004355:Drug Stability; D007093:Imidazoles / Q000737:chemistry*; D007700:Kinetics; D008956:Models, Chemical; D044367:Phase Transition; D033362:Powder Diffraction; D013816:Thermodynamics; D014961:X-Ray Diffraction
chemical_list: D058647:Adrenergic alpha-2 Receptor Agonists; D007093:Imidazoles; C041255:detomidine