title: The effects of a single nucleotide polymorphism in SLCO1B1 on the pharmacodynamics of pravastatin.
abstract: OBJECTIVE
  To determine whether the SNP rs4149056 in SLCO1B1 alters the pharmacodynamics of pravastatin.
  
  
  METHODS
  rs4149056 was genotyped in 626 pravastatin-treated participants in the WOSCOPS trial and the response after 1 year of treatment was compared between the different genotypes.
  
  
  RESULTS
  Pravastatin reduced serum LDL cholesterol by 22.2% in TT homozygotes, by 22.2% in TC heterozygotes and by 17.7% in CC homozygotes (TT + TC vs. CC P value 0.33). There were no significant differences in the response of total cholesterol, LDL, HDL, triglycerides or CRP to pravastatin between the genotypes.
  
  
  CONCLUSIONS
  The rs4149056 SNP did not significantly affect the pharmacodynamics of pravastatin.
authors.affiliation: Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, The Royal Free and University College London Medical School, London, UK.
authors.forename: Nicholas G
authors.initials: NG
authors.lastname: Martin
authors.forename: Ka Wah
authors.initials: KW
authors.lastname: Li
authors.forename: Heather
authors.initials: H
authors.lastname: Murray
authors.forename: Wendy
authors.initials: W
authors.lastname: Putt
authors.forename: Chris J
authors.initials: CJ
authors.lastname: Packard
authors.forename: Steve E
authors.initials: SE
authors.lastname: Humphries
mesh_terms: D000704:Analysis of Variance; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood / Q000235:genetics; D006801:Humans; D027381:Liver-Specific Organic Anion Transporter 1; D008297:Male; D008875:Middle Aged; D027361:Organic Anion Transporters / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D017035:Pravastatin / Q000494:pharmacology*; D012606:Scotland; D013997:Time Factors
chemical_list: D000924:Anticholesteremic Agents; D027381:Liver-Specific Organic Anion Transporter 1; D027361:Organic Anion Transporters; C503999:SLCO1B1 protein, human; D002784:Cholesterol; D017035:Pravastatin