title: How do I transfuse platelets (PLTs) to reverse anti-PLT drug effect?
abstract: Antiplatelet agents (APAs) are commonly used in clinical practice to either treat or prevent arterial thrombotic disorders in patients at high risk. The newer APAs are more potent with higher bleeding risk profiles. Patients who present with serious bleeds or need urgent surgical interventions while on APAs may require reversal of these agents' effect on PLTs. Currently, there are no guidelines for management of such patients. This article describes my approach to PLT transfusion or use of pharmacologic agents in such clinical scenarios based solely on personal experience and very limited published data.
authors.affiliation: Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9073, USA. ravi.sarode@utsouthwestern.edu
authors.forename: Ravi
authors.initials: R
authors.lastname: Sarode
mesh_terms: D001792:Blood Platelets / Q000502:physiology; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors; D017713:Platelet Transfusion; D058921:Purinergic P2Y Receptor Antagonists / Q000494:pharmacology
chemical_list: D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D058921:Purinergic P2Y Receptor Antagonists