title: Cascade reaction of isatins with heterocyclic ketene aminals: synthesis of imidazopyrroloquinoline derivatives.
abstract: A concise and efficient route for the synthesis of highly substituted imidazopyrroloquinoline derivatives by simply refluxing a reaction mixture of different types of isatins and heterocyclic ketene aminals (HKAs) by acetic acid was developed. This method is suitable for combinatorial and parallel syntheses in drug discovery; consequently, a library of highly substituted imidazopyrroloquinoline derivatives was rapidly constructed using the present protocol.
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resources (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, PR China.
authors.forename: Fuchao
authors.initials: F
authors.lastname: Yu
authors.forename: Shengjiao
authors.initials: S
authors.lastname: Yan
authors.forename: Ling
authors.initials: L
authors.lastname: Hu
authors.forename: Yongchao
authors.initials: Y
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
mesh_terms: D018360:Crystallography, X-Ray; D005030:Ethylenes / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D007510:Isatin / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D005030:Ethylenes; D006571:Heterocyclic Compounds; D007659:Ketones; D011804:Quinolines; D007510:Isatin; C008223:ketene