title: Influence of female bodyweight on IVF outcome: a longitudinal multicentre cohort study of 487 infertile couples.
abstract: This study investigated the impact of women's body mass index (BMI) on the outcome after consecutive IVF/intracytoplasmic sperm injection cycles in 487 patients initiating treatment with 5-year follow-up. The total number of cycles was 1417. In total 103 (21.1%) were overweight (BMI 25-29.9 kg/m²) and 59 (12.1%) were obese (BMI ≥ 30 kg/m²). Number of initiated cycles/woman (P=0.01), number of cancelled cycles/woman (P < 0.01) and the total dose of gonadotrophin used/cycle (P < 0.01) rose with increasing BMI. A negative linear association between BMI and the number of retrieved oocytes (B=-0.243, P < 0.001) and an inverse U-shaped relationship between BMI and the number of developed embryos was seen, with less embryos available among underweight and obese women (P=0.03). The number with positive serum human chorionic gonadotrophin/cycle decreased significantly with increasing BMI (P < 0.01). The ongoing pregnancy rate/cycle among the obese women was lower (20.8% versus 28.3% in normal-weight women; P=0.04). Live-birth rate per cycle was 15.2% versus 21.5%. Multiple logistic regression analysis showed that the only independent predictors of live birth were women's age (P=0.037), women's BMI (P=0.034) and men's age (P=0.040).
authors.affiliation: Fertility Clinic, The Juliane Marie Center, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark. pinborg@nru.dk
authors.forename: A
authors.initials: A
authors.lastname: Pinborg
authors.forename: C
authors.initials: C
authors.lastname: Gaarslev
authors.forename: C O
authors.initials: CO
authors.lastname: Hougaard
authors.forename: A
authors.initials: A
authors.lastname: Nyboe Andersen
authors.forename: P K
authors.initials: PK
authors.lastname: Andersen
authors.forename: J
authors.initials: J
authors.lastname: Boivin
authors.forename: L
authors.initials: L
authors.lastname: Schmidt
mesh_terms: D000328:Adult; D000367:Age Factors; D015992:Body Mass Index; D001835:Body Weight; D006063:Chorionic Gonadotropin / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D005500:Follow-Up Studies; D006801:Humans; D007246:Infertility / Q000209:etiology / Q000628:therapy*; D050498:Live Birth; D008297:Male; D009765:Obesity / Q000150:complications; D054315:Oocyte Retrieval; D050177:Overweight / Q000150:complications; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D020554:Sperm Injections, Intracytoplasmic
chemical_list: D006063:Chorionic Gonadotropin