title: Validation of candidate genes associated with cardiovascular risk factors in psychiatric patients.
abstract: The purpose of this study was to identify genetic variants predictive of cardiovascular risk factors in a psychiatric population treated with second generation antipsychotics (SGA). 924 patients undergoing treatment for severe mental illness at four US hospitals were genotyped at 1.2 million single nucleotide polymorphisms. Patients were assessed for fasting serum lipid (low density lipoprotein cholesterol [LDLc], high density lipoprotein cholesterol [HDLc], and triglycerides) and obesity phenotypes (body mass index, BMI). Thirteen candidate genes from previous studies of the same phenotypes in non-psychiatric populations were tested for association. We confirmed 8 of the 13 candidate genes at the 95% confidence level. An increased genetic effect size was observed for triglycerides in the psychiatric population compared to that in the cardiovascular population.
authors.affiliation: Genomas, Inc. and Genetics Research Center, Hartford Hospital, Hartford, CT 06106, USA.
authors.forename: Andreas
authors.initials: A
authors.lastname: Windemuth
authors.forename: Jose
authors.initials: J
authors.lastname: de Leon
authors.forename: John W
authors.initials: JW
authors.lastname: Goethe
authors.forename: Harold I
authors.initials: HI
authors.lastname: Schwartz
authors.forename: Stephen
authors.initials: S
authors.lastname: Woolley
authors.forename: Margaret
authors.initials: M
authors.lastname: Susce
authors.forename: Mohan
authors.initials: M
authors.lastname: Kocherla
authors.forename: Kali
authors.initials: K
authors.lastname: Bogaard
authors.forename: Theodore R
authors.initials: TR
authors.lastname: Holford
authors.forename: Richard L
authors.initials: RL
authors.lastname: Seip
authors.forename: Gualberto
authors.initials: G
authors.lastname: Ruaño
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000150:complications / Q000235:genetics*; D002784:Cholesterol / Q000097:blood; D005260:Female; D056726:Genetic Association Studies / Q000379:methods*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D014150:Antipsychotic Agents; D014280:Triglycerides; D002784:Cholesterol