title: Fragrance material review on 3-phenyl-1-propanol.
abstract: A toxicologic and dermatologic review of 3-phenyl-1-propanol when used as a fragrance ingredient is presented. 3-Phenyl-1-propanol is a member of the fragrance structural group cinnamyl phenylpropyl compounds. The common characteristic structural element of cinnamyl phenylpropyl materials is an aryl substituted primary alcohol/aldehyde/ester. They are simple aromatic compounds with saturated propyl or unsaturated propenyl side chains containing a primary oxygenated functional group which has little toxic potential. 3-Phenyl-1-propyl derivatives participate in the same beta-oxidation pathways as do their parent cinnamic acid derivatives. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 3-phenyl-1-propanol was evaluated then summarized and includes physical properties, acute toxicity, skin irritation, skin sensitization, in vitro skin absorption and mutagenicity. A safety assessment of all cinnamyl phenylpropyl compounds will be published simultaneously with this document; please refer to Belsito et al. (2011) for an overall assessment of the safe use of this material and all cinnamyl phenylpropyl materials in fragrances (Belsito, D., Bickers, D., Bruze, M., Dagli, M.L., Fryer, A., Greim, H., Miyachi, Y., Saurat, J.H., Sipes, I.G., 2011. A toxicologic and dermatologic assessment of cinnamyl phenylpropyl compounds when used as fragrance ingredients.).
authors.affiliation: Research Institute for Fragrance Materials Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA. sbhatia@rifm.org
authors.forename: S P
authors.initials: SP
authors.lastname: Bhatia
authors.forename: G A
authors.initials: GA
authors.lastname: Wellington
authors.forename: J
authors.initials: J
authors.lastname: Cocchiara
authors.forename: J
authors.initials: J
authors.lastname: Lalko
authors.forename: C S
authors.initials: CS
authors.lastname: Letizia
authors.forename: A M
authors.initials: AM
authors.lastname: Api
mesh_terms: D000818:Animals; D002934:Cinnamates / Q000737:chemistry / Q000633:toxicity; D004249:DNA Damage / Q000187:drug effects; D017449:Dermatitis, Allergic Contact / Q000473:pathology; D017484:Dermatitis, Phototoxic / Q000473:pathology; D005131:Eye Injuries / Q000139:chemically induced / Q000473:pathology; D006801:Humans; D009092:Mucous Membrane / Q000187:drug effects / Q000473:pathology; D009812:Odorants; D010476:Perfume / Q000737:chemistry* / Q000633:toxicity*; D020005:Propanols / Q000737:chemistry* / Q000633:toxicity*; D012867:Skin / Q000187:drug effects / Q000473:pathology; D018675:Toxicity Tests / Q000379:methods
chemical_list: D002934:Cinnamates; D010476:Perfume; D020005:Propanols; C016655:3-phenylpropanol-1