title: [Effect of anabolic preparation fenobolin on blood, reproductive system and hormone levels in blood serum of fractionally irradiated male rats].
abstract: Influence of anabolic drug (phenobolin) injection at a dose of 2.5 mg/kg on some indexes of blood, reproductive system, the level of thyroid hormones, corticosterone and testosterone in blood serum of the male rats exposed to a fractional irradiation at the total dose of 2.0 Gy have been studied. A significant decrease in the quantity of leucocytes and lymphocytes after a fractional irradiation without and with phenobolin introduction was determined. Introduction of anabolic drug resulted in a significant drop of relative mass of testes and, particularly, epididymes, and also in a sharp decrease of the number of mature germ cells isolated from epididymes. A combined action of phenobolin and fractional irradiation (2.0 Gy) led to a significant reduction (3-5 times) in the quantity of mature germ cells in an epididymis. In some cases phenobolin influenced the level of testosterone in blood serum of the intact and irradiated animals. The anabolic steroid drug affects negatively the state of reproductive system of male rats.
authors.forename: G G
authors.initials: GG
authors.lastname: Vereshchako
authors.forename: G A
authors.initials: GA
authors.lastname: Gorokh
authors.forename: O L
authors.initials: OL
authors.lastname: Fedosenko
authors.forename: N V
authors.initials: NV
authors.lastname: Gun'kova
authors.forename: D L
authors.initials: DL
authors.lastname: Iakushev
authors.forename: E F
authors.initials: EF
authors.lastname: Konoplia
mesh_terms: D045930:Anabolic Agents / Q000009:adverse effects*; D000818:Animals; D001772:Blood Cell Count; D003345:Corticosterone / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D004822:Epididymis / Q000187:drug effects / Q000528:radiation effects; D005720:Gamma Rays / Q000009:adverse effects*; D005837:Genitalia, Male / Q000187:drug effects / Q000528:radiation effects; D006728:Hormones / Q000097:blood*; D008297:Male; D009277:Nandrolone / Q000009:adverse effects / Q000031:analogs & derivatives*; D051381:Rats; D013091:Spermatogenesis / Q000187:drug effects / Q000528:radiation effects; D013737:Testis / Q000187:drug effects / Q000528:radiation effects; D013739:Testosterone / Q000097:blood; D013963:Thyroid Hormones / Q000097:blood
chemical_list: D045930:Anabolic Agents; D006728:Hormones; D013963:Thyroid Hormones; D013739:Testosterone; D009277:Nandrolone; C008580:nandrolone phenpropionate; D003345:Corticosterone