title: Metal ion mediated self-assembly directed formation of protein arrays.
abstract: Self-assembled inorganic-protein arrays with well-defined and controllable size and structure were obtained through the Fe(II) complexation of protein-conjugated terpyridine units (ligand). The atom-level control of the ligand is obtained through residue-specific conjugation between the complexing unit (terpy) containing an activity-based probe and a corresponding active enzyme (papain). The Fe(II)-based self-assembly performed on this unique building block (ligand) leads to chemical species of unprecedented constitution. The first example presented herein opens the way to a shape and size regime usually reserved to polymers.
authors.affiliation: Department of Chemistry, Technical University München, 4 Lichtenberg str, 85748 Garching, Germany.
authors.forename: Niculina D
authors.initials: ND
authors.lastname: Bogdan
authors.forename: Mihaela
authors.initials: M
authors.lastname: Matache
authors.forename: Gheorghe-Doru
authors.initials: GD
authors.lastname: Roiban
authors.forename: Cristian
authors.initials: C
authors.lastname: Dobrotă
authors.forename: Veronika M
authors.initials: VM
authors.lastname: Meier
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Funeriu
mesh_terms: D001709:Biotechnology / Q000379:methods*; D004591:Electrophoresis, Polyacrylamide Gel; D005296:Ferrous Compounds / Q000737:chemistry; D007477:Ions / Q000737:chemistry* / Q000378:metabolism; D008024:Ligands; D008670:Metals / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D015394:Molecular Structure; D010206:Papain / Q000737:chemistry / Q000378:metabolism*; D040081:Protein Array Analysis / Q000379:methods*; D011725:Pyridines / Q000737:chemistry* / Q000378:metabolism
chemical_list: D005296:Ferrous Compounds; D007477:Ions; D008024:Ligands; D008670:Metals; D011725:Pyridines; D010206:Papain