title: Hospital course and short-term outcomes of term and late preterm neonates following exposure to prolonged rupture of membranes and/or chorioamnionitis.
abstract: Our objective was to characterize the hospital course and short-term outcomes of neonates exposed to prolonged rupture of membranes (PROM), chorioamnionitis (CH), or both PROM and CH. Outcomes were positive blood culture and/or clinical signs of infection (+BC/CSI) prompting >4 days of antibiotics. Six neonates had a positive BC, 2 (0.6%) in the CH group and 4 (2.7%) in the PROM + CH group (P = 0.05); none of the neonates exposed to PROM alone had a +BC. These results support our current approach of withholding routine antibiotic therapy in neonates exposed to PROM alone.
authors.affiliation: Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. greg.jackson@utsouthwestern.edu
authors.forename: Gregory L
authors.initials: GL
authors.lastname: Jackson
authors.forename: Patricia
authors.initials: P
authors.lastname: Rawiki
authors.forename: Dorothy
authors.initials: D
authors.lastname: Sendelbach
authors.forename: M Denise
authors.initials: MD
authors.lastname: Manning
authors.forename: William D
authors.initials: WD
authors.lastname: Engle
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001769:Blood / Q000382:microbiology; D002821:Chorioamnionitis / Q000188:drug therapy*; D003470:Culture Media; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy*; D007902:Length of Stay; D018743:Perinatal Care / Q000379:methods*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D012307:Risk Factors; D018805:Sepsis / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media