title: Coumarin-Cu(II) ensemble-based cyanide sensing chemodosimeter.
abstract: An "ensemble"-based chemodosimeter 1-Cu(II) for cyanide detection is reported. 1-Cu(II) can recognize a cyanide ion over other anionic species to show a marked fluorescence enhancement under aqueous conditions. "Off-on" fluorescence change of 1-Cu(II) is proceeded by addition of cyanide, which induces decomplexation of the Cu(II) ion from nonfluorescent 1 followed by hydrolytic cleavage of the resulted Schiff base to give a strongly fluorescent coumarinaldehyde (2). The selective detection of cyanide with 1-Cu(II) for biological application was also performed in HepG2 cells.
authors.affiliation: Department of Chemistry, Korea University, Seoul, 136-704, Korea.
authors.forename: Hyo Sung
authors.initials: HS
authors.lastname: Jung
authors.forename: Ji Hye
authors.initials: JH
authors.lastname: Han
authors.forename: Zee Hwan
authors.initials: ZH
authors.lastname: Kim
authors.forename: Chulhun
authors.initials: C
authors.lastname: Kang
authors.forename: Jong Seung
authors.initials: JS
authors.lastname: Kim
mesh_terms: D003300:Copper / Q000737:chemistry*; D003374:Coumarins / Q000032:analysis* / Q000737:chemistry; D003486:Cyanides / Q000032:analysis*; D005456:Fluorescent Dyes / Q000032:analysis* / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation
chemical_list: D003374:Coumarins; D003486:Cyanides; D005456:Fluorescent Dyes; D003300:Copper; C030123:coumarin