title: Effect of training on airways inflammatory response and remodeling in a rat model.
abstract: Training has many beneficial effects, however few studies report its effects on the lungs. The aim of this study was to assess the effects of acute exercise and exercise training on inflammatory responses and remodeling in central and peripheral airways. Sixteen Sprague-Dawley rats trained for 10 weeks, while 14 rats served as controls. Before sacrifice, 8 trained (TR(AC)) and 8 untrained control (CON(AC)) rats underwent a single acute exercise bout, while 8 trained (TR) and 6 untrained control (CON) rats were sacrificed without acute exercise. The central and peripheral airways were morphologically examined for inflammatory cells and immunostained for decorin, collagen I, α-smooth muscle actin. No significant differences were found for morphometric analysis in central and peripheral airways, however CON(AC) showed a significant increase in polymorphonuclear cells in the central airways compared to CON. In contrast, TR(AC) did not show an inflammatory response different from TR. A similar trend was present in peripheral airways. Training did not induce differences in airways inflammation and remodeling as compared to CON. However, training seemed to limit the inflammatory response induced by acute exercise in the central airways.
authors.affiliation: Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy. pini@med.unibs.it
authors.forename: Laura
authors.initials: L
authors.lastname: Pini
authors.forename: Mauro
authors.initials: M
authors.lastname: Novali
authors.forename: Denise
authors.initials: D
authors.lastname: Modina
authors.forename: Chiara
authors.initials: C
authors.lastname: Torregiani
authors.forename: Mara S
authors.initials: MS
authors.lastname: Ludwig
authors.forename: Arsenio
authors.initials: A
authors.lastname: Veicsteinas
authors.forename: Fabio
authors.initials: F
authors.lastname: Esposito
mesh_terms: D056151:Airway Remodeling / Q000502:physiology*; D000818:Animals; D008297:Male; D010805:Physical Conditioning, Animal / Q000502:physiology*; D011014:Pneumonia / Q000276:immunology* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley