title: Comparative clinical study of coronally advanced flap with and without use of plasma rich in growth factors in the treatment of gingival recession.
abstract: OBJECTIVE
  To evaluate the clinical efficiency of the coronally advanced flap (CAF) with and without plasma rich in growth factors (PRGF) in the management of gingival recession defects.
  
  
  METHODS
  20 bilateral similar recession defects in six healthy non-smoker subjects were included in the present study. The test sites received PRGF as an adjunct to the coronally advanced flap (CAF) while the control sites were treated with CAF only. The clinical parameters including recession depth (RD), percentage of root coverage (RC), recession width (RW), mucogingival junction position (MGJ), width of keratinized tissue (WKT), clinical attachment level (CAL), and probing depth (PD) were measured at the baseline, 1, and 3 months post-operatively. The data were analyzed using Wilcoxon signed rank and Mann-Whitney U tests.
  
  
  RESULTS
  After 3 months, the mean root coverage was 43 +/- 34.9% in the CAF group and 61 +/- 23.5%) in the CAF + PRGF. Both treatment protocols led to a significant improvement in all measured variables compared to the baseline values, except the width of keratinized tissue. While PRGF enhanced the outcomes of CAF especially throughout the first month post-operatively, it offered no clinical advantage over CAF alone during the subsequent 2 months.
authors.affiliation: Department of Periodontics, Tabriz University of Medical Science, Tabriz, Iran.
authors.forename: Ardeshir
authors.initials: A
authors.lastname: Lafzi
authors.forename: Mohammad Taghi
authors.initials: MT
authors.lastname: Chitsazi
authors.forename: Ramin Mostofi Zadeh
authors.initials: RM
authors.lastname: Farahani
authors.forename: Masoumeh
authors.initials: M
authors.lastname: Faramarzi
mesh_terms: D000328:Adult; D003774:Dental Plaque Index; D005260:Female; D005500:Follow-Up Studies; D005881:Gingiva / Q000473:pathology; D005889:Gingival Recession / Q000145:classification / Q000473:pathology / Q000601:surgery*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000145:classification / Q000601:surgery; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000145:classification / Q000601:surgery; D053657:Platelet-Rich Plasma; D016037:Single-Blind Method; D013524:Surgical Flaps / Q000145:classification*; D014092:Tooth Root / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D036341:Intercellular Signaling Peptides and Proteins