title: Preferred performance of the high-performance membrane in the case of online hemodiafiltration.
abstract: High-performance membrane (HPM) dialyzers have become commonly used in online hemodiafiltration (ol-HDF). HPM dialyzers with a markedly improved function of removing high-molecular solutes have appeared, but excessive albumin loss often occurs using these. Higher albumin loss was observed when these protein-permeable dialyzers were used for post-dilution ol-HDF. When albumin loss is regarded as the criterion, dialyzers with a 0.5 g or lower albumin loss in the hemodialysis mode should be used for post-dilution HDF, whereas those with a 2 g or greater albumin loss should be selected for pre-dilution HDF. The performance of recent HPM dialyzers has been markedly developed, and equivalent removal efficiency can now be achieved with non-ol-HDF. To demonstrate the efficacy of ol-HDF, it is necessary to compare hemodialysis and ol-HDF using a type V dialyzer (β(2)-microglobulin clearance ≥70 ml/min) classified in Japan, and re-investigate the significance of removing high-molecular solutes larger than β(2)-microglobulin and protein-bound solutes.
authors.affiliation: Tsuchiya General Hospital, Hiroshima, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Kawanishi
mesh_terms: D001672:Biocompatible Materials; D001798:Blood Proteins / Q000378:metabolism; D017583:Hemodiafiltration / Q000295:instrumentation*; D006801:Humans; D007564:Japan; D008422:Materials Testing; D008567:Membranes, Artificial; D008970:Molecular Weight; D012709:Serum Albumin / Q000032:analysis; D014511:Uremia / Q000378:metabolism / Q000628:therapy; D001613:beta 2-Microglobulin / Q000032:analysis
chemical_list: D001672:Biocompatible Materials; D001798:Blood Proteins; D008567:Membranes, Artificial; D012709:Serum Albumin; D001613:beta 2-Microglobulin