title: Association of kisspeptin-10 levels with abortus imminens: a preliminary study.
abstract: OBJECTIVE
  To investigate the association between kisspeptin 10 (Kp-10) levels and early pregnancy bleeding and perinatal outcome.
  
  
  METHODS
  A total of 20 pregnant women with the complaint of vaginal bleeding during 7-18 gestational weeks and 20 healthy gestational week matched pregnant women were included in the study. Maternal plasma Kp-10 levels were measured with the enzyme immunoassay method. Adverse pregnancy outcomes like intrauterine growth restriction, preterm delivery, preeclampsia and low birth weight were evaluated in both groups.
  
  
  RESULTS
  Maternal plasma Kp-10 levels (p = 0.01) and birth weight (p = 0.06) were found to be lower in women with bleeding. Intrauterine growth restriction, preterm delivery and intrauterine exitus were noted more commonly in women with bleeding (10 vs. 0%, 25 vs. 15% and 20 vs. 0%, p = 0.08). Preeclampsia were developed in 5% of both groups. Kp-10 levels showed positive correlation with gestational week (p = 0.02) and ALT levels (p = 0.02).
  
  
  CONCLUSIONS
  [corrected] Kp-10 levels were found lower in women with early pregnancy bleeding.
authors.affiliation: Department of Obstetric and Gynecology, Firat Universitesi Hastanesi Kadin Dogum Anabilim Dali, 23119 Elazig, Turkey.
authors.forename: Serif
authors.initials: S
authors.lastname: Kavvasoglu
authors.forename: Zehra Sema
authors.initials: ZS
authors.lastname: Ozkan
authors.forename: Banu
authors.initials: B
authors.lastname: Kumbak
authors.forename: Mehmet
authors.initials: M
authors.lastname: Sımsek
authors.forename: Necip
authors.initials: N
authors.lastname: Ilhan
mesh_terms: D000033:Abortion, Threatened / Q000097:blood*; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D059648:Kisspeptins / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood; D011247:Pregnancy; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000097:blood; D014592:Uterine Hemorrhage / Q000097:blood; D055815:Young Adult
chemical_list: C106628:KISS1 protein, human; D059648:Kisspeptins; D000410:Alanine Transaminase