title: Consensus of the Spanish Society of Medical Oncology (SEOM) and Spanish Society of Pathology (SEAP) for HER2 testing in gastric carcinoma.
abstract: The identification of HER2 alterations in advanced gastric carcinomas is of critical importance in daily clinical practice as such neoplasms require specific treatment with trastuzumab. For these reasons, pathologists and oncologists with expertise in gastric carcinomas and HER2 testing from both organisations (SEAP and SEOM) have endeavoured to discuss and agree on national guidelines for HER2 testing in gastric carcinomas. These guidelines are based on the experience of those who participated in the discussions and also on experience published internationally. These agreed guidelines give the minimum requirements that a pathological anatomy laboratory must fulfil in order to guarantee adequate HER2 testing in daily practice. Any laboratories which do not meet the minimum standards set out in the guidelines must make every effort to achieve compliance.
authors.affiliation: GI Cancer Research Unit, Clinical Research Programme, National Cancer Research Centre, C/ Melchor Fernández Almagro 3, Madrid, Spain. cgomezm@cnio.es
authors.forename: Carlos
authors.initials: C
authors.lastname: Gómez-Martín
authors.forename: Angel
authors.initials: A
authors.lastname: Concha
authors.forename: José María
authors.initials: JM
authors.lastname: Corominas
authors.forename: Tomás
authors.initials: T
authors.lastname: García-Caballero
authors.forename: Elena
authors.initials: E
authors.lastname: García-García
authors.forename: Mar
authors.initials: M
authors.lastname: Iglesias
authors.forename: José Antonio
authors.initials: JA
authors.lastname: López
authors.forename: Santiago
authors.initials: S
authors.lastname: Ramón y Cajal
authors.forename: Federico
authors.initials: F
authors.lastname: Rojo
authors.forename: José
authors.initials: J
authors.lastname: Palacios
authors.forename: Francisco
authors.initials: F
authors.lastname: Vera-Sempere
authors.forename: Enrique
authors.initials: E
authors.lastname: Aranda
authors.forename: Ramon
authors.initials: R
authors.lastname: Colomer
authors.forename: Pilar
authors.initials: P
authors.lastname: García-Alfonso
authors.forename: Pilar
authors.initials: P
authors.lastname: Garrido
authors.forename: Fernando
authors.initials: F
authors.lastname: Rivera
authors.forename: Fernando
authors.initials: F
authors.lastname: López-Ríos
mesh_terms: D000465:Algorithms; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D002277:Carcinoma / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D019411:Clinical Laboratory Techniques / Q000379:methods; D002986:Clinical Trials as Topic; D018734:Genes, erbB-2 / Q000235:genetics; D005820:Genetic Testing / Q000379:methods* / Q000706:statistics & numerical data*; D006801:Humans; D008495:Medical Oncology / Q000331:legislation & jurisprudence / Q000379:methods / Q000458:organization & administration; D057089:Pathology, Molecular / Q000331:legislation & jurisprudence / Q000379:methods / Q000458:organization & administration; D017410:Practice Guidelines as Topic; D012955:Societies, Medical / Q000331:legislation & jurisprudence; D013030:Spain; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor