title: [Study on contamimation of endocrine disrupting chemicals in aquatic environment of Qiantang River].
abstract: OBJECTIVE
  To study contamination of endocrine disrupting chemicals (EDCs) in aquatic environment of Qiantang River.
  
  
  METHODS
  Carp vitellogenin (VTG) content in serum and ethoxyresorufin-o-deethylase (EROD) activity in liver of wild crucian, pesticide content including organic cholorine, organic phosphorus and pyrethroid in its muscle from 7 monitoring sites including Zhangtan (ZT), Jiekou (JK), Jiangjunyan (JJY), Yandongguan (YDG), Tonglu (TL), Fuyang (FY) and Yuanpu (YP) in Qiantang river were detected. And chemical analysis of water quality was carried on in four sites.
  
  
  RESULTS
  EROD activity in crucian from ZT, JJY, FY and YP [(23.51 +/- 4.17), (16.79 +/- 7.39), (18.74 +/- 5.16), (18.65 +/- 8.86) nmol x g(-1) pro x min(-1), respectively] was significantly higher than that of control ((7.84 +/- 2.42) nmol x g(-1) pro x min(-1)), and VTG content in wild crucian from ZT, TL, FY and YP [(1.536 +/- 0.521), (16.404 +/- 13.579), (19.672 +/- 16.354) and (17.079 +/- 18.397)] microg/ml, respectively) was significantly higher than that of control [(0.400 +/- 0.099) (microg/ ml]. No significantly difference in biomarkers was observed between other site and control. From high to low, in total organophosphorus, it was followed as: TL, YDG, YP, FY, QZ, JK, JJY (EPN was up to 2695.64, 611.96 microg/kg in TL and YDG, respectively). In total organochlorine: TL, YP, YDG, FY, QZ, JK and JJY (tetradifon content in muscle of wild crucian from TL was up to 3962.17 microg/kg). For pyrethroid pesticides: TL, YDG, YP, ZT, JK, FY and JJY (alpha-tetramethrin and alpha-phenothrin was comparatively high in TL and YDG, up to 371.54, 239.62 microg/kg in the former, 416.23, 189.15 microg/kg in the latter, respectively).
  
  
  CONCLUSIONS
  Aquatic environment of these sites including ZT, TL, FY and YP in Qiantang river received comparatively high EDCs, whose effects may be mainly due to pesticide pollution. Obvious organic contamination occurred in these sites including ZT, JJY, FY and YP. Changes of chemicals in water and EROD activity in fish test result are consistent with the actual contamination, while agricultural effluent discharges only affect the local River in the downstream. High PAH contamination in these sites such as ZT maybe lead to underestimation of estrogen effects, which was neglected easily, need be paid more attention to.
authors.affiliation: Zhejiang Center for Disease Control and Prevention, Hangzhou 310051, China. dlcai@cdc.zj.cn
authors.forename: Delei
authors.initials: D
authors.lastname: Cai
authors.forename: Jiang
authors.initials: J
authors.lastname: Chen
authors.forename: Jianyun
authors.initials: J
authors.lastname: Fu
authors.forename: Yunyan
authors.initials: Y
authors.lastname: Zheng
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Song
authors.forename: Jun
authors.initials: J
authors.lastname: Yan
authors.forename: Gangqiang
authors.initials: G
authors.lastname: Ding
mesh_terms: D000818:Animals; D002347:Carps / Q000378:metabolism; D002681:China; D019363:Cytochrome P-450 CYP1A1 / Q000378:metabolism; D052244:Endocrine Disruptors / Q000032:analysis*; D004784:Environmental Monitoring; D010575:Pesticides / Q000378:metabolism; D045483:Rivers; D014819:Vitellogenins / Q000097:blood; D014874:Water Pollutants, Chemical / Q000032:analysis*
chemical_list: D052244:Endocrine Disruptors; D010575:Pesticides; D014819:Vitellogenins; D014874:Water Pollutants, Chemical; D019363:Cytochrome P-450 CYP1A1