title: How practice and science are balanced and blended in the NIDA Clinical Trials Network: the bidirectional process in the development of the STAGE-12 protocol as an example.
abstract: BACKGROUND
  Bidirectional, collaborative partnerships between academic researchers and practitioners have been a fundamental vehicle to achieve the National Institute on Drug Abuse (NIDA) Clinical Trials Network (CTN) goal of improving outcomes of community-based drug treatment. These partnerships blend clinical perspectives of practitioners and methodological expertise of researchers working together to address clinically meaningful issues through randomized clinical trials conducted in community treatment settings.
  
  
  OBJECTIVE
  Bidirectionality is a guiding principle of the CTN, but its operationlization at the practical level in protocol development and implementation has not been articulated. This descriptive article presents the development of one protocol as an example and model of this bidirectional, collaborative, iterative partnership between researchers and practitioners.
  
  
  METHODS
  This article illuminates several specific issues encountered while developing STAGE-12, a behavioral intervention to facilitate 12-step mutual support group involvement, as well as the rationale for decisions taken to resolve each.
  
  
  RESULTS
  The STAGE-12 protocol was successfully developed through a series of decisions taking into account both design factors and clinical practice needs and realities, thus maintaining a balance between methodological rigor and generalizability.
  
  
  CONCLUSIONS
  The review demonstrates the process by which research and practice have been blended in protocol development, exemplifying the underlying principle of bidirectionality, a key element in the success of the NIDA CTN.
  
  
  CONCLUSIONS
  Bidirectional partnerships as derived in the CTN, employing a hybrid model of efficacy-effectiveness research, are capable of designing and implementing protocols that are both methodologically rigorous and clinically meaningful, thus increasing likelihood of adoption and eventual improvement in public health.
authors.affiliation: Alcohol & Drug Abuse Institute, University of Washington, Seattle, 98105-4631, USA. ddonovan@u.washington.edu
authors.forename: Dennis M
authors.initials: DM
authors.lastname: Donovan
authors.forename: Dennis C
authors.initials: DC
authors.lastname: Daley
authors.forename: Gregory S
authors.initials: GS
authors.lastname: Brigham
authors.forename: Candace C
authors.initials: CC
authors.lastname: Hodgkins
authors.forename: Harold I
authors.initials: HI
authors.lastname: Perl
authors.forename: Anthony S
authors.initials: AS
authors.lastname: Floyd
mesh_terms: D002985:Clinical Protocols; D003153:Community Health Services / Q000379:methods*; D003299:Cooperative Behavior; D003657:Decision Making; D006801:Humans; D054577:National Institute on Drug Abuse (U.S.); D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D012107:Research Design; D012657:Self-Help Groups / Q000458:organization & administration; D019966:Substance-Related Disorders / Q000534:rehabilitation*; D014481:United States