title: [Translational research in head and neck cancer. Biological characteristics and general aspects].
abstract: Translational research in head and neck oncology is subject to the same laws as all other solid tumors. It is based on the one hand on a solid framework of well prepared clinical studies and / or workflows according to consensus criteria with comparable documentation of clinical outcomes, while on the other on methodolgically solid and reproducible laboratory research within an effeciently interacting network. Translationally applicable single molecular markers from basic research [with the exception of p16(INK4a) as a surrogate marker for human papillomavirus (HPV)] have not found their way into clinical routine in head and neck squamous cell carcinoma (HNSCC). "Correlated gene sets" and "metagenes", including genetic profiling (omics) within clinically characterized patient groups, play an increasing role in the translational research of HNSCC. Although methodological problems currently hinder clinical oncological research, increasing focus on translational research can be observed.
authors.affiliation: Klinik und Poliklinik für HNO-Erkrankungen, Universitätsklinikum Leipzig, Liebigstr. 10-14, 04103, Leipzig, Deutschland. andreas.dietz@medizin.uni-leipzig.de
authors.forename: A
authors.initials: A
authors.lastname: Dietz
authors.forename: G
authors.initials: G
authors.lastname: Wichmann
mesh_terms: D018070:Biological Specimen Banks; D015415:Biomarkers; D014408:Biomarkers, Tumor / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology; D059186:Chemoradiotherapy, Adjuvant; D002872:Chromosome Deletion; D003131:Combined Modality Therapy; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000235:genetics; D018572:Disease-Free Survival; D066246:ErbB Receptors / Q000235:genetics; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D009367:Neoplasm Staging; D010039:Otorhinolaryngologic Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D030361:Papillomavirus Infections / Q000235:genetics / Q000473:pathology; D011379:Prognosis; D015398:Signal Transduction / Q000235:genetics; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D058570:TOR Serine-Threonine Kinases / Q000235:genetics; D057170:Translational Research, Biomedical; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
chemical_list: D015415:Biomarkers; D014408:Biomarkers, Tumor; D019941:Cyclin-Dependent Kinase Inhibitor p16; D016159:Tumor Suppressor Protein p53; C546842:MTOR protein, human; C512478:EGFR protein, human; D066246:ErbB Receptors; D058570:TOR Serine-Threonine Kinases