title: [Correction of the alkylnitrite method for the detection of ethanol in blood taking into account toxico-kinetic and anthropometric data].
abstract: The correction coefficient for the systemic inaccuracy arising during determination of blood ethanol by alkylnitrite gas chromatography and concomitant calibration of aqueous solutions was estimated to equal 0.82; this finding was confirmed by the results of the toxico-kinetic assay for the measurement of total body water (TBW) from the kinetic curve characterizing the time dependence of ethanol concentration in the exhaled air, saliva, capillary and venous blood in combination with 4 anthropometric methods and (in several cases) direct physical detection of TBW. When detecting the blood ethanol level with a correction coefficient of 0.82, the mutual position of the kinetic curves for ethanol concentrations in the blood and the exhaled air (recalculated for the blood level with a coefficient of 2100) as well as in the blood and saliva agreed with that reported in the available literature; it significantly differed from the position of the curves obtained with a correction coefficient of 0.95. The causes accounting for the systematic inaccuracy and erroneous values of the correction coefficients in earlier studies are discussed.
authors.forename: T O
authors.initials: TO
authors.lastname: Barinskaia
authors.forename: E M
authors.initials: EM
authors.lastname: Salomatin
authors.forename: A V
authors.initials: AV
authors.lastname: Smirnov
mesh_terms: D000328:Adult; D001774:Blood Chemical Analysis / Q000592:standards*; D001834:Body Water; D002138:Calibration; D002849:Chromatography, Gas / Q000592:standards*; D000431:Ethanol / Q000097:blood / Q000493:pharmacokinetics / Q000592:standards; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012015:Reference Standards; D012107:Research Design; D012463:Saliva; D012737:Sex Factors; D013048:Specimen Handling / Q000592:standards; D015813:Substance Abuse Detection / Q000379:methods / Q000592:standards; D013997:Time Factors
chemical_list: D000431:Ethanol