title: Insight: prolonged vaginal bleeding during central precocious puberty therapy with a long-acting gonadotropin-releasing hormone agonist: a proposed mechanism and management plan.
abstract: We have previously described our data collected after administration of gonadotropin releasing hormone-agonist (GnRH-a) to delay sexual maturation, in premenarchal girls suffering from idiopathic central precocious puberty.(1) We have explained the recurrent episodes of bleeding due to discontinuation of the estrogen support of the proliferative and stable endometrium. The recognition in recent years of the extra-pituitary functions of GnRH-a, the ability of GnRH to stimulate prostaglandin production and the known role of prostaglandins in irregular vaginal bleeding prompted us to seek alternative explanations to our data. We suggest considering a potential clinical use of combination therapies of GnRH agonists and prostanoid receptor antagonists to treat central precocious puberty.
authors.affiliation: Pediatric Department, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Arieh
authors.initials: A
authors.lastname: Kauschansky
authors.forename: Raoul
authors.initials: R
authors.lastname: Orvieto
authors.forename: Arie
authors.initials: A
authors.lastname: Yeshaya
authors.forename: Boris
authors.initials: B
authors.lastname: Shterntal
authors.forename: Zvi
authors.initials: Z
authors.lastname: Naor
mesh_terms: D051546:Cyclooxygenase 2 / Q000378:metabolism; D015232:Dinoprostone / Q000378:metabolism; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists* / Q000378:metabolism; D006801:Humans; D011629:Puberty, Precocious / Q000188:drug therapy*; D011982:Receptors, Prostaglandin / Q000037:antagonists & inhibitors*; D015398:Signal Transduction; D014592:Uterine Hemorrhage / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D011982:Receptors, Prostaglandin; D007987:Gonadotropin-Releasing Hormone; D051546:Cyclooxygenase 2; D015232:Dinoprostone