title: Enantioselective α-arylation of carbonyls via Cu(I)-bisoxazoline catalysis.
abstract: The enantioselective α-arylation of both lactones and acyl oxazolidones has been accomplished using a combination of diaryliodonium salts and copper catalysis. These mild catalytic conditions provide a new strategy for the enantioselective construction and retention of enolizable α-carbonyl benzylic stereocenters, a valuable synthon for the production of medicinal agents.
authors.affiliation: Merck Center for Catalysis at Princeton University, New Jersey 08544, United States.
authors.forename: James S
authors.initials: JS
authors.lastname: Harvey
authors.forename: Scott P
authors.initials: SP
authors.lastname: Simonovich
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Jamison
authors.forename: David W C
authors.initials: DW
authors.lastname: MacMillan
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry*; D010080:Oxazoles / Q000737:chemistry*; D023303:Oxazolidinones / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D006841:Hydrocarbons, Aromatic; D007783:Lactones; D010080:Oxazoles; D023303:Oxazolidinones; D003300:Copper