title: The effect of resveratrol on blood pressure in a rat model of preeclampsia.
abstract: OBJECTIVE
  To examine the hypothesis that resveratrol administration could result in blood pressure and blood flow decrease in a rat preeclampsia model.
  
  
  METHODS
  Desoxycorticosterone acetate (DOCA) was used to produce hypertension. The Wistar albino rats were divided randomly into three groups: control (n = 12), DOCA injected (n = 11), and DOCA injected and resveratrol treated (n = 13). Rats were sacrificed on gestational day 16-20. The systolic blood pressure was measured by the tail-cuff method. Urine protein was expressed as protein/creatinine. Laser Doppler measurements of the blood flow were made in one placenta, the left kidney and both parietal lobes of brain. Placentas were examined by light microscopy.
  
  
  RESULTS
  DOCA injected group exhibited significant differences in blood pressure and protein/creatinine. Mean blood pressure in DOCA-treated rats was 130.1 ± 12.9 mmHg at baseline and 148.4 ± 20.1 mmHg at the time of euthanization (p = 0.044). Resveratrol did not significantly affect blood pressure, placental and renal blood flows. There were also no significant differences in placental pathology parameters among the three groups.
  
  
  CONCLUSIONS
  The present study demonstrated that resveratrol did not decrease blood pressure, and did not result in a significant response in blood flows and placental pathology parameters.
authors.affiliation: Zekai Tahir Burak Woman's Health Education and Research Hospital, Department of Perinatology, Ankara, Turkey. ozlem.moraloglu@hotmail.com
authors.forename: Ozlem
authors.initials: O
authors.lastname: Moraloglu
authors.forename: Yaprak
authors.initials: Y
authors.lastname: Engin-Ustun
authors.forename: Esra
authors.initials: E
authors.lastname: Tonguç
authors.forename: Turgut
authors.initials: T
authors.lastname: Var
authors.forename: Omer Lütfü
authors.initials: OL
authors.lastname: Tapisiz
authors.forename: Hakan
authors.initials: H
authors.lastname: Ergün
authors.forename: Tolga
authors.initials: T
authors.lastname: Guvenc
authors.forename: Ayhan
authors.initials: A
authors.lastname: Gacar
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects*; D004195:Disease Models, Animal; D015536:Down-Regulation / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D011225:Pre-Eclampsia / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012079:Renal Circulation / Q000187:drug effects; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000959:Antihypertensive Agents; D000975:Antioxidants; D013267:Stilbenes; D000077185:Resveratrol