title: Aluminum chloride hexahydrate in a salicylic acid gel base: a case series of combination therapy with botulinum toxin type A for moderate to severe hyperhidrosis.
abstract: Hyperhidrosis is a common condition that has a tremendous impact on the quality of life of patients. For moderate to severe hyperhidrosis, topical aluminum chloride hexahydrate (AC), iontophoresis, and botulinum toxin type A injections are first-line therapies. Botulinum toxin type A has been a useful addition to the hyperhidrosis armamentarium and typically is utilized when topical therapy or iontophoresis have failed. Although highly effective for most patients, there remains a subset of patients who do not completely respond to botulinum toxin type A injections. For these patients, combination therapy with AC can greatly improve patient response. We present a case series of 10 patients with hyperhidrosis and a history of partial response to botulinum toxin type A monotherapy. With the addition of AC 15% in a salicylic acid 2% gel base, 5 patients achieved 75% to 100% reduction in sweating and 5 patients achieved 100% reduction in sweating. Aluminum chloride hexahydrate in a salicylic acid gel base offers a novel and effective topical therapy in combination with botulinum toxin type A for patients with moderate to severe hyperhidrosis.
authors.affiliation: University of Miami, Department of Dermatology and Cutaneous Surgery, University of Miami Cosmetic Medicine and Research Institute, Miami Beach, FL 33140, USA. woolerylloyd@yahoo.com
authors.forename: Heather
authors.initials: H
authors.lastname: Woolery-Lloyd
authors.forename: Whitney
authors.initials: W
authors.lastname: Valins
mesh_terms: D000328:Adult; D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000008:administration & dosage*; D001252:Astringents / Q000008:administration & dosage*; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage*; D002712:Chlorides / Q000008:administration & dosage*; D015331:Cohort Studies; D004359:Drug Therapy, Combination; D005782:Gels; D006801:Humans; D006945:Hyperhidrosis / Q000188:drug therapy*; D007641:Keratolytic Agents / Q000008:administration & dosage; D008875:Middle Aged; D009498:Neurotoxins / Q000008:administration & dosage*; D020156:Salicylic Acid / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D017607:Aluminum Compounds; D001252:Astringents; D002712:Chlorides; D005782:Gels; D007641:Keratolytic Agents; D009498:Neurotoxins; D000077410:Aluminum Chloride; D019274:Botulinum Toxins, Type A; D020156:Salicylic Acid