title: Mid-regional pro atrial natriuretic peptide allows the accurate identification of patients with atrial fibrillation of short time of onset: a pilot study.
abstract: OBJECTIVE
  Atrial fibrillation (AF) is a common arrhythmia; its most prevalent and devastating complication is stroke. A delay of AF onset >48 h is believed to be clinically significant. Mid-regional pro A-type natriuretic peptide (MR-proANP) could be of interest in the identification of the time from onset of AF to presentation.
  
  
  METHODS
  We measured MR-proANP plasma concentration at presentation in consecutive patients in whom onset of AF was determined, without evidence of concomitant acute heart failure.
  
  
  RESULTS
  Forty-seven patients were included. Patients with an AF onset <48 h (n=19) had decreased MR-proANP concentrations versus patients with onset >48 h (144.0 [129.2-213.7] versus 321.7 [236.4-425.6] pmol/L, p<0.001); MR-proANP was the only independent variable associated with AF <48 h according to multivariate analysis. Area under the ROC curve for identify AF onset <48 h was 0.878 [95%CI 0.778-0.978].
  
  
  CONCLUSIONS
  MR-proANP concentration may reliably identify the time from onset of AF to presentation.
authors.affiliation: Université Paris Descartes, Département de Cardiologie, Groupe Hospitalier Cochin-Broca-Hôtel Dieu, Assistance Publique des Hôpitaux de Paris, 27 rue du Fbg St-Jacques, 75679 Paris Cedex 14, France. christophe.meune@cch.aphp.fr
authors.forename: Christophe
authors.initials: C
authors.lastname: Meune
authors.forename: Adeline
authors.initials: A
authors.lastname: Vermillet
authors.forename: Karim
authors.initials: K
authors.lastname: Wahbi
authors.forename: Sylvie
authors.initials: S
authors.lastname: Guerin
authors.forename: Hélène
authors.initials: H
authors.lastname: Aelion
authors.forename: Simon
authors.initials: S
authors.lastname: Weber
authors.forename: Camille
authors.initials: C
authors.lastname: Chenevier-Gobeaux
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000097:blood* / Q000175:diagnosis*; D009320:Atrial Natriuretic Factor / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006333:Heart Failure / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010865:Pilot Projects; D011237:Predictive Value of Tests; D020521:Stroke / Q000097:blood
chemical_list: D015415:Biomarkers; C552580:midregional pro-atrial natriuretic peptide, human; D009320:Atrial Natriuretic Factor