title: Early biological fixation of porous implant coated with paste-retaining recombinant bone morphogenetic protein 2.
abstract: The aim of this study was to evaluate the period required for stable initial bone-implant fixation with recombinant human bone morphogenetic protein 2 (rhBMP-2) in the bone marrow of a rabbit model. The porous implants being coated with β-tricalcium phosphate/polylactide-polyethylene glycol paste with 15, 30, or 60 μg of rhBMP-2 (n = 10) were implanted into animals in 3 experimental groups. In 2 control groups, the test implants were coated without rhBMP or no paste. In all groups, the implant was inserted for 3 and 6 weeks. At 3 weeks after implantation, the BMP-treated implants in the 2 lower dose groups had significantly more bone ingrowth to the implant surface than did the control groups, and the greatest effect occurred in the 30-μg rhBMP-2 group animals.
authors.affiliation: Department of Orthopaedic Surgery, Osaka City University Graduated School of Medicine, Osaka, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Fukunaga
authors.forename: Yukihide
authors.initials: Y
authors.lastname: Minoda
authors.forename: Kentaro
authors.initials: K
authors.lastname: Iwakiri
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Iwaki
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nakamura
authors.forename: Kunio
authors.initials: K
authors.lastname: Takaoka
mesh_terms: D000818:Animals; D001686:Biological Phenomena; D055396:Bone Morphogenetic Protein 2; D001842:Bone and Bones / Q000601:surgery*; D020099:Coated Materials, Biocompatible; D005260:Female; D020007:Implants, Experimental; D008422:Materials Testing; D016348:Osseointegration; D016062:Porosity; D011474:Prosthesis Design; D060489:Prosthesis Retention; D011817:Rabbits; D011994:Recombinant Proteins; D013997:Time Factors; D016212:Transforming Growth Factor beta
chemical_list: D055396:Bone Morphogenetic Protein 2; D020099:Coated Materials, Biocompatible; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2