title: Radioelectric brain stimulation in the treatment of generalized anxiety disorder with comorbid major depression in a psychiatric hospital: a pilot study.
abstract: BACKGROUND
  Generalized anxiety disorder (GAD) is often presented with major depression (MD). GAD-MD can be a chronic and disabling condition, and patients suffering from this disorder often respond poorly to psychopharmacological treatment and experience side effects with medication. Therefore, there is a high demand for effective nonpharmacological therapy for GAD-MD patients. The current study explores the use of a radioelectric asymmetric conveyer (REAC) device in the treatment of GAD-MD.
  
  
  METHODS
  Participants were 24 patients diagnosed with GAD-MD being treated at a public psychiatric center. All patients were dissatisfied with their current pharmacological treatment. Patients were evaluated using the 21-item Hamilton Depression (HAM-D) rating scale and the Symptom Check List-90-Revised (SCL-90R) before and after REAC brain stimulation treatment cycles.
  
  
  RESULTS
  After REAC brain stimulation treatment, all patients experienced a significant reduction in anxiety and depression. These results were confirmed by physician examination, HAM-D scores, and SCL-90R total scores.
  
  
  CONCLUSIONS
  These results indicate a role for REAC brain stimulation in the management of psychiatric conditions, specifically, GAD-MD comorbidity. REAC treatments are synergistic to drug therapy and appear to be helpful in reducing the side effects of medication. Future studies should evaluate the long-term effects of REAC treatment.
authors.affiliation: Healthcare enterprise Hospital Trust S Croce and Carle Complex Structure of Psychiatry, Cuneo, Italy;
authors.forename: Elisabetta Bourget
authors.initials: EB
authors.lastname: Olivieri
authors.forename: Caterina
authors.initials: C
authors.lastname: Vecchiato
authors.forename: Nunziatina
authors.initials: N
authors.lastname: Ignaccolo
authors.forename: Piero
authors.initials: P
authors.lastname: Mannu
authors.forename: Alessandro
authors.initials: A
authors.lastname: Castagna
authors.forename: Lucia
authors.initials: L
authors.lastname: Aravagli
authors.forename: Vania
authors.initials: V
authors.lastname: Fontani
authors.forename: Salvatore
authors.initials: S
authors.lastname: Rinaldi