title: Enantioselective α-arylation of N-acyloxazolidinones with copper(II)-bisoxazoline catalysts and diaryliodonium salts.
abstract: A new strategy for the catalytic enantioselective α-arylation of N-acyloxazolidinones with chiral copper(II)-bisoxazoline complexes and diaryliodonium salts is described. The mild catalytic conditions are operationally simple, produce valuable synthetic building blocks in excellent yields and enantioselectivities, and can be applied to the synthesis of important nonsteroidal anti-inflammatory agents and their analogues.
authors.affiliation: Department of Chemistry, University of Cambridge, United Kingdom.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Bigot
authors.forename: Alice E
authors.initials: AE
authors.lastname: Williamson
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Gaunt
mesh_terms: D001713:Biphenyl Compounds / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D009861:Onium Compounds / Q000737:chemistry*; D023303:Oxazolidinones / Q000737:chemistry*; D012492:Salts / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001713:Biphenyl Compounds; D006841:Hydrocarbons, Aromatic; D009861:Onium Compounds; D023303:Oxazolidinones; D012492:Salts; C031291:diphenyliodonium; D003300:Copper