title: Phosphorylimidazole derivatives: potentially biosignaling molecules.
abstract: The phosphorylation of imidazole by two activated phosphate diesters and a triester gives phosphorylimidazole derivatives that are stable enough in aqueous solution to be observed and identified by ESI-MS/MS and NMR. Half-lives ranging from hours to days (in the case of the monoethyl ester) show that it is possible to design molecules with variable half-lives with potential to be used for biological intervention experiments as possible inhibitors of biosignaling processes or as haptens for the generation of antibodies.
authors.affiliation: INCT-Catalise, Universidade Federal de Santa Catarina, Florianópolis, SC 88040-900, Brazil.
authors.forename: Elisa S
authors.initials: ES
authors.lastname: Orth
authors.forename: Eduardo H
authors.initials: EH
authors.lastname: Wanderlind
authors.forename: Michelle
authors.initials: M
authors.lastname: Medeiros
authors.forename: Pedro S M
authors.initials: PS
authors.lastname: Oliveira
authors.forename: Boniek G
authors.initials: BG
authors.lastname: Vaz
authors.forename: Marcos N
authors.initials: MN
authors.lastname: Eberlin
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Kirby
authors.forename: Faruk
authors.initials: F
authors.lastname: Nome
mesh_terms: D015195:Drug Design; D004952:Esters; D007093:Imidazoles / Q000737:chemistry* / Q000378:metabolism*; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D015398:Signal Transduction; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D004952:Esters; D007093:Imidazoles; C033780:phosphorylimidazole