title: Muscle type-specific expression of Zasp52 isoforms in Drosophila.
abstract: Zasp52 is a member of the PDZ-LIM domain protein family in Drosophila, which comprises Enigma, ENH, ZASP, Alp, CLP36, RIL, and Mystique in vertebrates. Drosophila Zasp52 colocalizes with integrins at myotendinous junctions and with α-actinin at Z-disks, and is required for muscle attachment as well as Z-disk assembly and maintenance. Here we document 13 Zasp52 splice variants giving rise to six different LIM domains. We demonstrate stage- and tissue-specific expression in different muscle types for Zasp52 isoforms encoding different LIM domains. In particular, LIM1b is expressed only in heart muscle and certain somatic muscles, implying muscle-specific functions in Z-disk assembly or maintenance.
authors.affiliation: Department of Biology, McGill University, 1205 Dr. Penfield Avenue, Montreal, Quebec, Canada H3A 1B1.
authors.forename: Anja
authors.initials: A
authors.lastname: Katzemich
authors.forename: Jenny Yanyan
authors.initials: JY
authors.lastname: Long
authors.forename: Klodiana
authors.initials: K
authors.lastname: Jani
authors.forename: Byeo Ri
authors.initials: BR
authors.lastname: Lee
authors.forename: Frieder
authors.initials: F
authors.lastname: Schöck
mesh_terms: D000185:Actinin / Q000096:biosynthesis; D000818:Animals; D002352:Carrier Proteins; D029721:Drosophila Proteins / Q000096:biosynthesis*; D004331:Drosophila melanogaster; D005786:Gene Expression Regulation / Q000502:physiology*; D060588:LIM Domain Proteins / Q000096:biosynthesis*; D009124:Muscle Proteins / Q000096:biosynthesis*; D009132:Muscles / Q000378:metabolism*; D009928:Organ Specificity / Q000502:physiology
chemical_list: D002352:Carrier Proteins; D029721:Drosophila Proteins; D060588:LIM Domain Proteins; D009124:Muscle Proteins; C526450:Zasp52 protein, Drosophila; D000185:Actinin