title: Lipocalin 2 regulation and its complex role in inflammation and cancer.
abstract: Lipocalin 2 is a protein that has garnered a great deal of interest in multidisciplinary fields over the last two decades since its discovery. However, its exact function in metabolic processes remains to be completely characterized. More recently, it has come to light as a highly upregulated protein in the setting of injury and infection. This review focuses on lipocalin 2 regulation and its relationship to cytokine and endocrine signaling pathways.
authors.affiliation: Division of Pulmonary, Allergy & Critical Care Medicine, University of Pittsburgh, 3459 Fifth Avenue, NW 628 MUH, Pittsburgh, PA 15213, United States.
authors.forename: Chen
authors.initials: C
authors.lastname: Li
authors.forename: Yvonne R
authors.initials: YR
authors.lastname: Chan
mesh_terms: D000209:Acute-Phase Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D001483:Base Sequence; D004247:DNA; D018450:Disease Progression; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D000071068:Lipocalin-2; D054834:Lipocalins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000503:physiopathology*; D011401:Promoter Regions, Genetic; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D000209:Acute-Phase Proteins; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins; D004247:DNA