title: Critical insights into cardiovascular disease from basic research on the oxidation of phospholipids: the γ-hydroxyalkenal phospholipid hypothesis.
abstract: Basic research, exploring the hypothesis that γ-hydroxyalkenal phospholipids are generated in vivo through oxidative cleavage of polyunsaturated phospholipids, is delivering a bonanza of molecular mechanistic insights into cardiovascular disease. Rather than targeting a specific pathology, these studies were predicated on the presumption that a fundamental understanding of lipid oxidation is likely to provide critical insights into disease processes. This investigational approach, from the chemistry of biomolecules to disease phenotype, that complements the more common opposite paradigm, is proving remarkably productive.
authors.affiliation: Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106-7078, USA. rgs@case.edu
authors.forename: Robert G
authors.initials: RG
authors.lastname: Salomon
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Gu
mesh_terms: D000447:Aldehydes / Q000009:adverse effects / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D018955:CD36 Antigens / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D003331:Coronary Vessels / Q000378:metabolism* / Q000503:physiopathology; D005609:Free Radicals / Q000009:adverse effects / Q000378:metabolism; D006321:Heart / Q000503:physiopathology*; D022781:Hepatocytes / Q000166:cytology / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism; D008244:Lysophosphatidylcholines / Q000737:chemistry / Q000378:metabolism*; D051379:Mice; D009000:Monocytes / Q000166:cytology / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000378:metabolism; D010084:Oxidation-Reduction; D010587:Phagocytosis; D011499:Protein Processing, Post-Translational; D051122:Scavenger Receptors, Class B / Q000378:metabolism; D021241:Spectrometry, Mass, Electrospray Ionization; D013927:Thrombosis / Q000378:metabolism; D051195:Toll-Like Receptor 2 / Q000378:metabolism
chemical_list: D000447:Aldehydes; D018955:CD36 Antigens; D005609:Free Radicals; D008077:Lipoproteins, LDL; D008244:Lysophosphatidylcholines; C495124:SCARB1 protein, human; D051122:Scavenger Receptors, Class B; C495342:TLR2 protein, human; D051195:Toll-Like Receptor 2; C027576:4-hydroxy-2-nonenal