title: New imidazopyridopyrimidine:naphthyridine base-pairing motif, ImN(N):NaO(O), consisting of a DAAD:ADDA hydrogen bonding pattern, markedly stabilize DNA duplexes.
abstract: The new imidazopyridopyrimidine:naphthyridine base-pairing motifs, ImO(O):NaN(N) and ImN(N):NaO(O), were designed. Among the base pairs examined, DNA duplexes containing ImN(N):NaO(O) pair(s) consisting of a DAAD:ADDA hydrogen bonding pattern (D = donor, A = acceptor) were markedly stabilized thermally and thermodynamically.
authors.affiliation: Fuculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Sapporo 060-0812, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Kuramoto
authors.forename: Noriko
authors.initials: N
authors.lastname: Tarashima
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Hirama
authors.forename: Yusaku
authors.initials: Y
authors.lastname: Kikuchi
authors.forename: Noriaki
authors.initials: N
authors.lastname: Minakawa
authors.forename: Akira
authors.initials: A
authors.lastname: Matsuda
mesh_terms: D020029:Base Pairing; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D006860:Hydrogen Bonding; D007093:Imidazoles / Q000737:chemistry*; D009287:Naphthyridines / Q000737:chemistry*; D009693:Nucleic Acid Hybridization; D009838:Oligodeoxyribonucleotides / Q000737:chemistry / Q000378:metabolism; D011743:Pyrimidines / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D007093:Imidazoles; D009287:Naphthyridines; D009838:Oligodeoxyribonucleotides; D011743:Pyrimidines; D004247:DNA