title: Lactobacillus rhamnosus administration causes sepsis in a cardiosurgical patient--is the time right to revise probiotic safety guidelines?
abstract: A 24-year-old female patient developed sepsis resulting from preoperative administration of probiotics following an aortic valve replacement. Blood cultures revealed the causative agent to be the probiotic Lactobacillus rhamnosus, which has recently been implicated as an emerging aetiology of infection in those taking probiotics. In the past few years, probiotic use in hospitals has increased greatly. However, there is growing global evidence that the use of probiotics in patients with organ failure, immunocompromised status and dysfunctional gut barrier mechanisms can cause infections. This and other reports show the importance of establishing generally recognized safety guidelines.
authors.affiliation: Chair of Microbiology, Jagiellonian University Medical College in Cracow, Cracow, Poland. pkochan@cm-uj.krakow.pl
authors.forename: P
authors.initials: P
authors.lastname: Kochan
authors.forename: A
authors.initials: A
authors.lastname: Chmielarczyk
authors.forename: L
authors.initials: L
authors.lastname: Szymaniak
authors.forename: M
authors.initials: M
authors.lastname: Brykczynski
authors.forename: K
authors.initials: K
authors.lastname: Galant
authors.forename: A
authors.initials: A
authors.lastname: Zych
authors.forename: K
authors.initials: K
authors.lastname: Pakosz
authors.forename: S
authors.initials: S
authors.lastname: Giedrys-Kalemba
authors.forename: E
authors.initials: E
authors.lastname: Lenouvel
authors.forename: P B
authors.initials: PB
authors.lastname: Heczko
mesh_terms: D000328:Adult; D001021:Aortic Valve / Q000601:surgery*; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D005838:Genotype; D006761:Hospitals; D006801:Humans; D052201:Lacticaseibacillus rhamnosus / Q000472:pathogenicity*; D019936:Probiotics / Q000008:administration & dosage / Q000009:adverse effects* / Q000592:standards; D018805:Sepsis / Q000209:etiology* / Q000382:microbiology