title: Interferon regulatory factors: beyond the antiviral response and their link to the development of autoimmune pathology.
abstract: Abnormal production of interferon type I has been widely related to multiple autoimmune diseases, particularly systemic lupus erythematosus (SLE). It has been considered the molecular signature characterized by the overexpression of type I Interferon related genes in SLE patients. Among these, are the interferon regulatory factors (IRF). These transcription factors have been involved in the innate immune response, mainly the one related to the defense against viral infections; the development of immune cells and carcinogenesis. The role of IRF in autoimmune pathology has been addressed in diverse murine models. However, evidence in humans is quite scant. This review will focus on the evidence that supports the role of IRF in the development or susceptibility to autoimmune diseases. Specific emphasis will be made over the role of IRF-5 and IRF-7, since evidence of its association to the development of pathology, particularly systemic lupus erythematosus is the strongest.
authors.affiliation: Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Tlalpan, Mexico City, Mexico.
authors.forename: Karina
authors.initials: K
authors.lastname: Santana-de Anda
authors.forename: Diana
authors.initials: D
authors.lastname: Gómez-Martín
authors.forename: Mariana
authors.initials: M
authors.lastname: Díaz-Zamudio
authors.forename: Jorge
authors.initials: J
authors.lastname: Alcocer-Varela
mesh_terms: D000818:Animals; D015551:Autoimmunity / Q000235:genetics*; D002454:Cell Differentiation / Q000235:genetics / Q000276:immunology; D019070:Cell Lineage; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007113:Immunity, Innate; D050835:Interferon Regulatory Factors / Q000235:genetics / Q000276:immunology; D007370:Interferon Type I / Q000235:genetics / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology; D051379:Mice; D010802:Phylogeny; D011110:Polymorphism, Genetic; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology; D051193:Toll-Like Receptors / Q000235:genetics / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology* / Q000503:physiopathology / Q000821:virology; D014780:Viruses / Q000276:immunology
chemical_list: D050835:Interferon Regulatory Factors; D007370:Interferon Type I; D051193:Toll-Like Receptors