title: Prognostic implication of types of tumor-associated macrophages in Hodgkin lymphoma.
abstract: To evaluate roles of tumor-associated macrophages (TAMs) for prognosis of classical Hodgkin lymphoma (CHL). Expression of markers for TAMs, CD68, HLA-DR, CD163, HLA-DR/CD68 (M1), and CD163/CD68 (M2) was immunohistochemically examined in 82 cases with CHL. Positively stained cells were counted and correlation of number of TAMs and patients' survival time was analyzed. Number of CD163+ cells and M2 cells was significantly correlated with shorter overall survival (P < 0.05), while it was marginally significant for CD68+ cells (P = 0.0827). HLA-DR + cells and M1 cells showed no significant correlation with overall survival. When confined to mixed cellularity subtype, number of M1 cells was correlated with favorable prognosis (P < 0.05), while M2 did not (P = 0.7). Older age and male sex were unfavorable factors for prognosis. At multivariate analysis, number of CD163+ cells, M2+ cells, and age were independent factors for poor overall survival (P = 0.03, 0.02, and 0.01, respectively). CD163+ cells and M2 cells might work to be tumor promotive in CHL. M1 cells might be tumor suppressive in mixed cellularity type.
authors.affiliation: Department of Pathology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
authors.forename: Mona A A
authors.initials: MA
authors.lastname: Zaki
authors.forename: Naoki
authors.initials: N
authors.lastname: Wada
authors.forename: Junichiro
authors.initials: J
authors.lastname: Ikeda
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Shibayama
authors.forename: Koji
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Yamagami
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Tatsumi
authors.forename: Machiko
authors.initials: M
authors.lastname: Tsukaguchi
authors.forename: Hironori
authors.initials: H
authors.lastname: Take
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Tsudo
authors.forename: Eiichi
authors.initials: E
authors.lastname: Morii
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Aozasa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006689:Hodgkin Disease / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D055815:Young Adult