title: Studies on pectin coating of liposomes for drug delivery.
abstract: The present study investigated the surface coating of charged liposomes by three different types of pectin (LM, HM and amidated pectin) by particle size determinations and zeta potential measurements. The pectins and the pectin coated liposomes were visualized by atomic force microscopy. The adsorption of pectin onto positive liposomes yielded a reproducible increase in particle size and a shift of the zeta potential from positive to negative side for all three pectin types, whereas the adsorption of pectin onto negative liposomes did not render any significant changes probably due to electrostatic repulsion. The positive liposomes coated with HM-pectin gave the largest pectin coated particles with the least negative zeta potential, while the opposite was observed for the LM-pectin coated positive liposomes. Furthermore, results from dynamic light scattering revealed narrow size distributions, indicating that the degree of aggregation was low for the pectin coated liposomes. As liposomes are able to encapsulate drugs and pectin has been found to be mucoadhesive, these pectin coated liposomes may be potential drug delivery systems.
authors.affiliation: Department of Pharmacy, School of Pharmacy, University of Oslo, Oslo, Norway. s.h.nguyen@farmasi.uio.no
authors.forename: Sanko
authors.initials: S
authors.lastname: Nguyen
authors.forename: Siv Jorunn
authors.initials: SJ
authors.lastname: Alund
authors.forename: Marianne
authors.initials: M
authors.lastname: Hiorth
authors.forename: Anna-Lena
authors.initials: AL
authors.lastname: Kjøniksen
authors.forename: Gro
authors.initials: G
authors.lastname: Smistad
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods*; D008081:Liposomes / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D010368:Pectins / Q000737:chemistry*
chemical_list: D008081:Liposomes; D010368:Pectins