title: The relationship between serial postinfarction T wave changes and infarct size and ventricular function as determined by cardiac magnetic resonance imaging.
abstract: BACKGROUND
  The value of sequential T wave changes on the electrocardiogram (ECG) has less well been described than ST-segment changes in the follow-up of patients with myocardial infarction (MI). We investigated whether the amplitude of T wave positivity correlates with infarct size (IS) and left ventricular ejection fraction (LVEF) measured using cardiac magnetic resonance imaging 3 months after reperfusion therapy.
  
  
  METHODS
  Fifty-five patients with a first acute MI referred for primary percutaneous coronary intervention were included. Electrocardiograms were analyzed within 4 hours after reperfusion and at 3 months, measuring T wave ampitudes in 2 contiguous infarct-related leads, summed up as one value called T wave amplitude. Cardiac magnetic resonance imaging was performed at 3 months of follow-up. Correlations between T wave amplitude, IS, and LVEF were tested with Pearson r correlation coefficient test. Subanalyses were performed using a 2-sample t test.
  
  
  RESULTS
  A good correlation was found between LVEF and IS (r = -0.7, P < .0001). Most of the patients had inferior MI location (69%). In this group, there were significant positive correlations between the amount of T wave positivity and both IS (r = -0.40, P = .012) and LVEF (r = 0.33, P = .043). Results were similar in patients with and without an increase in T wave amplitude during follow-up.
  
  
  CONCLUSIONS
  In this study of patients with reperfused MI, patients with inferior locations demonstrated a statistically significant relationship between the amount of positivity of T wave amplitude and both IS and LVEF measured at 3 months. Furthermore, these results were independent of whether the T wave positivity was persistent or evolutionary between the immediate postreperfusion and 3-month ECG recordings.
authors.affiliation: Department of Cardiology, Catharina Hospital Eindhoven, The Netherlands. meijs.loek@gmail.com
authors.forename: Loek P
authors.initials: LP
authors.lastname: Meijs
authors.forename: Anton P M
authors.initials: AP
authors.lastname: Gorgels
authors.forename: Sebastiaan C A
authors.initials: SC
authors.lastname: Bekkers
authors.forename: Charles C
authors.initials: CC
authors.lastname: Maynard
authors.forename: Miguel E
authors.initials: ME
authors.lastname: Lemmert
authors.forename: Galen S
authors.initials: GS
authors.lastname: Wagner
mesh_terms: D003287:Contrast Media; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000473:pathology* / Q000503:physiopathology* / Q000628:therapy; D015425:Myocardial Reperfusion / Q000379:methods; D012307:Risk Factors; D013318:Stroke Volume
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA