title: Effect of narrow band ultraviolet B on survivin in psoriatic skin lesions.
abstract: BACKGROUND
  Suppression of apoptosis is responsible for epidermal thickness in psoriasis. Survivin is an anti-apoptotic protein that can be modulated by ultraviolet B (UVB).
  
  
  OBJECTIVE
  Our aim was to investigate the role of survivin in psoriasis and to evaluate the effect of narrow band (NB)-UVB on the survivin levels in psoriatic lesions.
  
  
  METHODS
  This study included 20 psoriatic patients and 20 healthy controls. Patients were treated with 24 sessions of NB-UVB. Skin biopsies were taken from the affected skin of each patient before and after treatment, and from the controls, to examine survivin levels by ELISA.
  
  
  RESULTS
  Survivin was significantly upregulated in psoriasis compared to controls (p&#60;0.001). We found significant positive correlations between survivin levels before therapy and the extent of body involvement (r=0.675, p=0.002), as well as the PASI score (r=0.67, p=0.001). A significant decrease in survivin levels was observed post treatment compared to baseline levels (p&#60;0.001).
  
  
  CONCLUSIONS
  We found increased survivin levels in psoriasis and a significant reduction following NB-UVB induced clinical improvement of psoriasis.
authors.affiliation: Department of Dermatology, Cairo University Faculty of Medicine, Egypt.
authors.forename: Noha Abdel Rehim
authors.initials: NA
authors.lastname: Nagui
authors.forename: Rania Mounir
authors.initials: RM
authors.lastname: Abdel Hay
authors.forename: Laila Ahmed
authors.initials: LA
authors.lastname: Rashed
mesh_terms: D000293:Adolescent; D000328:Adult; D017209:Apoptosis / Q000502:physiology; D005260:Female; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism* / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000378:metabolism* / Q000532:radiotherapy*; D000077022:Survivin; D014467:Ultraviolet Therapy; D055815:Young Adult
chemical_list: C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin