title: Protective effects of selenium on acrylamide toxicity in the liver of the rat. Effects on the oxidative stress.
abstract: Acrylamide (AA), obtained for the first time by Moureu in Germany in 1893, is presently used as polyacrylamide in water treatment and wastewater treatment, paper and pulp processing, mineral processing, crude-oil production processes. Acrylamide is a chemical product formed when frying, roasting, grilling or baking carbohydrate-rich foods at temperatures above 120 degrees C. Acrylamide is thus found in a number of foods, such as bread, crisps, French fries and coffee. Tobacco smoking also generates substantial amounts of acrylamide. Acrylamide administration is associated with significant increase of oxidative stress parameters; acrylamide caused disturbances in the oxidative status and enzyme activities and the effect was pronounced with the high doses.
  
  
  METHODS
  This study investigates the effect of selenium (as sodium selenite and as a selenium dietary supplements--Celnium) on the oxidative stress in Wistar rats which received high doses of acrylamide.
  
  
  RESULTS
  The administration of sodium selenite and selenium dietary supplements (Celnium) significantly increased GSH and GPx levels and decreased MDA compared to group which received only acrylamide.
  
  
  CONCLUSIONS
  Our results show that sodium selenite and selenium dietary supplements (Celnium) can partially prevent the biochemical changes in the liver of the rats which received high doses of acrylamide.
authors.affiliation: Gr. T. Popa University of Medicine and Pharmacy Iaşi, School of Pharmacy, Department of Environmental and Food Chemistry.
authors.forename: V
authors.initials: V
authors.lastname: Teodor
authors.forename: Magdalena
authors.initials: M
authors.lastname: Cuciureanu
authors.forename: Cristiana
authors.initials: C
authors.lastname: Filip
authors.forename: Nina
authors.initials: N
authors.lastname: Zamosteanu
authors.forename: Rodica
authors.initials: R
authors.lastname: Cuciureanu
mesh_terms: D020106:Acrylamide; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000188:drug therapy*; D004195:Disease Models, Animal; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D020011:Protective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000008:administration & dosage / Q000494:pharmacology*; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D020011:Protective Agents; D020106:Acrylamide; D005979:Glutathione Peroxidase; D005978:Glutathione; D012643:Selenium