title: Volumetry and other quantitative measurements to assess the rodent brain.
abstract: Morphometry is defined as studying variations in and changes of shapes. Evaluation of shape changes in the brain is a key step in the development of new mouse models, the monitoring of different pathologies, and measuring environmental influences. Traditional morphometry was performed by manual shape delineation, so-called volumetry. Currently, automated methods have been developed that can be roughly divided into three groups: voxel-based morphometry, deformation-based morphometry, and shape-based morphometry. In this chapter, we describe the different approaches for quantitative morphometry and how they can be applied to the quantitative analysis of the rodent brain.
authors.affiliation: Division of Image Processing, Department of Radiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands. a.scheenstra@nki.nl
authors.forename: Alize
authors.initials: A
authors.lastname: Scheenstra
authors.forename: Jouke
authors.initials: J
authors.lastname: Dijkstra
authors.forename: Louise
authors.initials: L
authors.lastname: van der Weerd
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D012377:Rodentia