title: NMR imaging of chitosan and carboxymethyl starch tablets: swelling and hydration of the polyelectrolyte complex.
abstract: The hydration and swelling properties of the tablets made of chitosan, carboxymethyl starch, and a polyelectrolyte complex of these two polysaccharides have been studied by NMR imaging. We studied the effect of pH and ionic strength on the swelling of the tablets and on the diffusion of fluid into the tablets in water and simulated physiological fluids. The pH value of the fluids exerts a more significant effect than their ionic strengths on the swelling of the tablets. The tablets are compared also with those made of cross-linked high amylose starch. The formation of complex helps to keep the integrity of the tablets in various media and render a slow and restricted swelling similar to that of the tablets of the cross-linked high amylase starch, which is significantly lower than the swelling of chitosan and of carboxymethyl starch. The capacities to modulate the release rate of drugs in different media are discussed by comparing the matrices and evaluating the preparation process of the complex. A sustained release of less soluble drugs such as aspirin in gastrointestinal fluids can be provided by the complex, due to the ionic interaction and hydrogen bonding between the drug and the biopolymer complex.
authors.affiliation: Département de Chimie, Université de Montréal, CP 6128, Succ. Centre-ville, Montreal, QC, H3C 3J7, Canada.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Wang
authors.forename: E
authors.initials: E
authors.lastname: Assaad
authors.forename: P
authors.initials: P
authors.lastname: Ispas-Szabo
authors.forename: M A
authors.initials: MA
authors.lastname: Mateescu
authors.forename: X X
authors.initials: XX
authors.lastname: Zhu
mesh_terms: D000688:Amylose / Q000737:chemistry; D001241:Aspirin / Q000008:administration & dosage* / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D005750:Gastric Juice / Q000378:metabolism; D006860:Hydrogen Bonding; D006863:Hydrogen-Ion Concentration; D007419:Intestinal Secretions / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D009994:Osmolar Concentration; D012995:Solubility; D013213:Starch / Q000031:analogs & derivatives* / Q000737:chemistry; D013607:Tablets; D014867:Water / Q000737:chemistry
chemical_list: D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D013607:Tablets; D014867:Water; D013213:Starch; D000688:Amylose; D048271:Chitosan; C034848:carboxymethyl starch; D001241:Aspirin