title: An efficient synthesis of hydropyrido[1,2-a]indole-6(7H)-ones via an In(III)-catalyzed tandem cyclopropane ring-opening/Friedel-Crafts alkylation sequence.
abstract: An efficient Lewis acid-catalyzed cyclopropane ring-opening/Friedel-Crafts alkylation sequence of methyl 1-(1H-indole-carbonyl)-1-cyclopropanecarboxylates is reported. The protocol affords functionalized hydropyrido[1,2-a]indole-6(7H)-ones in up to 99% yield.
authors.affiliation: School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.
authors.forename: Dadasaheb V
authors.initials: DV
authors.lastname: Patil
authors.forename: Marchello A
authors.initials: MA
authors.lastname: Cavitt
authors.forename: Paul
authors.initials: P
authors.lastname: Grzybowski
authors.forename: Stefan
authors.initials: S
authors.lastname: France
mesh_terms: D000478:Alkylation; D002384:Catalysis; D003500:Cyclization; D003521:Cyclopropanes / Q000737:chemistry*; D007204:Indium / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D058116:Lewis Acids / Q000737:chemistry
chemical_list: D003521:Cyclopropanes; D007211:Indoles; D058116:Lewis Acids; D007204:Indium; C030797:cyclopropane