title: Appraising contemporary strategies to combat multidrug resistant gram-negative bacterial infections--proceedings and data from the Gram-Negative Resistance Summit.
abstract: The emerging problem of antibiotic resistance, especially among Gram-negative bacteria (GNB), has become a serious threat to global public health. Very few new antibacterial classes with activity against antibiotic-resistant GNB have been brought to market. Renewed and growing attention to the development of novel compounds targeting antibiotic-resistant GNB, as well as a better understanding of strategies aimed at preventing the spread of resistant bacterial strains and preserving the efficacy of existing antibiotic agents, has occurred. The Gram-Negative Resistance Summit convened national opinion leaders for the purpose of analyzing current literature, epidemiologic trends, clinical trial data, therapeutic options, and treatment guidelines related to the management of antibiotic-resistant GNB infections. After an in-depth analysis, the Summit investigators were surveyed with regard to 4 clinical practice statements. The results then were compared with the same survey completed by 138 infectious disease and critical care physicians and are the basis of this article.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, 660 South Euclid Ave, Campus Box 8052, St Louis, MO 63110, USA. mkollef@dom.wustl.edu
authors.forename: Marin H
authors.initials: MH
authors.lastname: Kollef
authors.forename: Yoav
authors.initials: Y
authors.lastname: Golan
authors.forename: Scott T
authors.initials: ST
authors.lastname: Micek
authors.forename: Andrew F
authors.initials: AF
authors.lastname: Shorr
authors.forename: Marcos I
authors.initials: MI
authors.lastname: Restrepo
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D024901:Drug Resistance, Multiple, Bacterial; D006090:Gram-Negative Bacteria; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'
chemical_list: D000900:Anti-Bacterial Agents