title: [Bioinformatics analysis of the structure and function correlated to interferon sensitivity of HCV core protein].
abstract: OBJECTIVE
  To analyze and predict the structure and function correlated to interferon sensitivity of HCV Core protein in different genotypes.
  
  
  METHODS
  Using different bioinformafics software respectively to comparatively analyze and predict the secondary structure, tertiary structure, modification site and main functional motifs of HCV Core protein.
  
  
  RESULTS
  There were diversities in secondary structure and tertiary structure of different genotypes. HCV Core protein would exist some modification sites about amidation, cAMP, PKC, TYR, and interact with amphiphysin SH3 domain, ERK, PKC.
  
  
  CONCLUSIONS
  Differences in structure and function of HCV Core protein of different genotypes affected interferon sensitivity.
authors.affiliation: PLA Institute of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Cheng
authors.forename: Yan
authors.initials: Y
authors.lastname: Guo
authors.forename: Guo-hu
authors.initials: GH
authors.lastname: Hong
authors.forename: Qing
authors.initials: Q
authors.lastname: Mao
mesh_terms: D000595:Amino Acid Sequence; D019295:Computational Biology; D016174:Hepacivirus / Q000737:chemistry / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D006526:Hepatitis C / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D007372:Interferons / Q000627:therapeutic use*; D008969:Molecular Sequence Data; D011487:Protein Conformation; D014758:Viral Core Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*
chemical_list: D014758:Viral Core Proteins; C069130:nucleocapsid protein, Hepatitis C virus; D007372:Interferons