title: Kidney tubular toxicity of maintenance pemetrexed therapy.
abstract: Pemetrexed is an antifolate agent approved for the treatment of advanced lung cancer. Major side effects include myelosuppression and neutropenia. Three patients developed kidney disease while being treated with maintenance pemetrexed. Kidney biopsy specimens showed tubulointerstitial injury with tubular simplification, shrinkage, loss of brush border, and tubular atrophy in a more advanced case. Kidney function remained impaired, but stable, after discontinuation of pemetrexed therapy in all cases.
authors.affiliation: Renal Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. glezermi@mskcc.org
authors.forename: Ilya G
authors.initials: IG
authors.lastname: Glezerman
authors.forename: M Catherine
authors.initials: MC
authors.lastname: Pietanza
authors.forename: Vincent
authors.initials: V
authors.lastname: Miller
authors.forename: Surya V
authors.initials: SV
authors.lastname: Seshan
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D005260:Female; D005971:Glutamates / Q000009:adverse effects*; D006147:Guanine / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced*; D007684:Kidney Tubules; D008297:Male; D008875:Middle Aged; D000068437:Pemetrexed
chemical_list: D000964:Antimetabolites, Antineoplastic; D005971:Glutamates; D000068437:Pemetrexed; D006147:Guanine