title: Prevention of selenite-induced cataractogenesis by Origanum vulgare extract.
abstract: The present study sought to assess antioxidant effect of Origanum vulgare extract in preventing selenite-induced cataractogenesis. This study was performed on Young white rats received sodium selenite (30 nmol g(-1) birth weight) subcutaneously on day 13 post partum during two months in 2009. Cataract formation and intensity was detected and measured by slit-lamp. Origanum vulgare (Ov) extract (2 g kg(-1)) was given (1-2 times) intraperitoneal at different times with respect to the selenite administration lens opacification was analyzed in selenite, selenite-Ov, Ov and control groups on day 7 after selenite administration. Ov extract have revealed a significant protective effect against selenite induced cataract when injected 1 and 2 day (2 times) before selenite injection. There is a protective effect of Ov against selenite induced cataract formation. It is supposed that the anticataract effect of Ov extract could be based on direct or indirect antioxidant mechanisms.
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: K N
authors.initials: KN
authors.lastname: Dailami
authors.forename: M
authors.initials: M
authors.lastname: Azadbakht
authors.forename: Z R
authors.initials: ZR
authors.lastname: Pharm
authors.forename: M
authors.initials: M
authors.lastname: Lashgari
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D002386:Cataract / Q000139:chemically induced / Q000517:prevention & control*; D007908:Lens, Crystalline / Q000187:drug effects; D031341:Origanum / Q000737:chemistry*; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D018038:Sodium Selenite
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D018038:Sodium Selenite