title: One-dimensional deterministic transport in neurons measured by dispersion-relation phase spectroscopy.
abstract: We studied the active transport of intracellular components along neuron processes using a new method developed in our laboratory: dispersion-relation phase spectroscopy. This method is able to quantitatively map spatially the heterogeneous dynamics of the concentration field of the cargos at submicron resolution without the need for tracking individual components. The results in terms of density correlation function reveal that the decay rate is linear in wavenumber, which is consistent with a narrow Lorentzian distribution of cargo velocity.
authors.affiliation: Department of Mechanical Science and Engineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
authors.forename: Ru
authors.initials: R
authors.lastname: Wang
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Wang
authors.forename: Joe
authors.initials: J
authors.lastname: Leigh
authors.forename: Nahil
authors.initials: N
authors.lastname: Sobh
authors.forename: Larry
authors.initials: L
authors.lastname: Millet
authors.forename: Martha U
authors.initials: MU
authors.lastname: Gillette
authors.forename: Alex J
authors.initials: AJ
authors.lastname: Levine
authors.forename: Gabriel
authors.initials: G
authors.lastname: Popescu
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000502:physiology*; D002478:Cells, Cultured; D003198:Computer Simulation; D006801:Humans; D008857:Microscopy, Interference; D008858:Microscopy, Phase-Contrast; D008962:Models, Theoretical; D009474:Neurons / Q000166:cytology* / Q000378:metabolism* / Q000648:ultrastructure; D022161:Transport Vesicles / Q000378:metabolism*