title: The effect of nicotine on the recovery of rats receiving anesthesia.
abstract: OBJECTIVE
  To determine the effect of intraperitoneal (ip) nicotine on the recovery of rats receiving general anesthesia compared with placebo.
  
  
  METHODS
  The placebo controlled experimental study was conducted in the Faculty of Medicine, Gazi University, Turkey, between April and May 2005. Twenty-one male and 21 female rats were randomly divided into 3 groups. Group C (n=14), comprising a female group CF (n=7), and male group CM (n=7) received ip 0.9% sodium chloride (NaCl), group P (n=14), comprising a female group PF (n=7), and male group PM (n=7) received ip propofol 150 mg/kg, and group NP (n=14), comprising a female group NPF (n=7), and male group NPM (n=7) received 0.4 mg/kg ip nicotine followed by 150 mg/kg propofol after 15 minutes. For the evaluation of recovery period, tail pinch test was used, and for cognitive performance, the radial arm maze test was used.
  
  
  RESULTS
  The number of entrances and exits decreased in group P significantly compared to group C (p<0.05), and the decrease in group PF was higher than it was in group PM. Entrance and exit in group NP increased significantly compared to group P (p<0.05). The increase in entrance and exit in group NPF was much higher compared to group NPM. The recovery period in group NP was significantly shorter than in group P (p<0.05).
  
  
  CONCLUSIONS
  The ip administration of nicotine in rats shortens the recovery from propofol anesthesia and improves cognitive performance.
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Gazi University, Ankara, Turkey.
authors.forename: Berrin
authors.initials: B
authors.lastname: Isik
authors.forename: Mustafa
authors.initials: M
authors.lastname: Arslan
authors.forename: Ozgur
authors.initials: O
authors.lastname: Ozsoylar
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Unal
authors.forename: Cengiz B
authors.initials: CB
authors.lastname: Demirel
authors.forename: Nedim
authors.initials: N
authors.lastname: Cekmen
authors.forename: Omer
authors.initials: O
authors.lastname: Kurtipek