title: Comparison of efficacy between continuous hemodiafiltration with a PMMA high-performance membrane dialyzer and a PAN membrane hemofilter in the treatment of septic shock patients with acute renal failure.
abstract: The aim of this study was to investigate whether continuous hemodiafiltration (CHDF) with a high-performance membrane dialyzer made of polymethylmethacrylate (PMMA-CHDF) in the treatment of septic shock patients with acute renal failure (ARF) is clinically relevant. 30 patients were treated with PMMA-CHDF. 13 patients treated with CHDF used a hemofilter made of polyacrylonitrile membrane (PAN-CHDF). Systolic blood pressure significantly increased in the PMMA-CHDF group following 24 h of treatment (p < 0.01), whereas it did not improve in the PAN-CHDF group. Urine volume significantly increased in the PMMA-CHDF group following 24 h of treatment which was more than in the PAN-CHDF group (p < 0.05). 28-day survival was 83.3% in the PMMA-CHDF group and 30.8% in the PAN-CHDF group, respectively (p < 0.01). We can assume that PMMA-CHDF in the treatment of septic shock patients with ARF is clinically relevant.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Matsuda
authors.forename: Takeshi
authors.initials: T
authors.lastname: Moriguchi
authors.forename: Norikazu
authors.initials: N
authors.lastname: Harii
authors.forename: Masahiko
authors.initials: M
authors.lastname: Yanagisawa
authors.forename: Daiki
authors.initials: D
authors.lastname: Harada
authors.forename: Hisanori
authors.initials: H
authors.lastname: Sugawara
mesh_terms: D000180:Acrylic Resins; D058186:Acute Kidney Injury / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*; D000327:Adsorption; D000368:Aged; D001834:Body Water / Q000378:metabolism; D003131:Combined Modality Therapy; D004232:Diuretics / Q000627:therapeutic use; D005260:Female; D005440:Fluid Therapy; D005665:Furosemide / Q000627:therapeutic use; D017583:Hemodiafiltration / Q000295:instrumentation / Q000379:methods*; D006440:Hemofiltration / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D007022:Hypotension / Q000209:etiology / Q000628:therapy; D018836:Inflammation Mediators / Q000097:blood; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D019904:Polymethyl Methacrylate; D012720:Severity of Illness Index; D012772:Shock, Septic / Q000150:complications* / Q000628:therapy; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D000180:Acrylic Resins; D004232:Diuretics; D018836:Inflammation Mediators; D008567:Membranes, Artificial; C010504:polyacrylonitrile; D005665:Furosemide; D019904:Polymethyl Methacrylate