title: Ischemia-induced neural stem/progenitor cells express pyramidal cell markers.
abstract: Adult brain-derived neural stem cells have acquired a lot of interest as an endurable neuronal cell source that can be used for central nervous system repair in a wide range of neurological disorders such as ischemic stroke. Recently, we identified injury-induced neural stem/progenitor cells in the poststroke murine cerebral cortex. In this study, we show that, after differentiation in vitro, injury-induced neural stem/progenitor cells express pyramidal cell markers Emx1 and CaMKIIα, as well as mature neuron markers MAP2 and Tuj1. 5-bromo-2-deoxyuridinine-positive neurons in the peristroke cortex also express such pyramidal markers. The presence of newly regenerated pyramidal neurons in the poststroke brain might provide a noninvasive therapeutic strategy for stroke treatment with functional recovery.
authors.affiliation: Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
authors.forename: Martijn
authors.initials: M
authors.lastname: Clausen
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nakagomi
authors.forename: Akiko
authors.initials: A
authors.lastname: Nakano-Doi
authors.forename: Orie
authors.initials: O
authors.lastname: Saino
authors.forename: Masashi
authors.initials: M
authors.lastname: Takata
authors.forename: Akihiko
authors.initials: A
authors.lastname: Taguchi
authors.forename: Paul
authors.initials: P
authors.lastname: Luiten
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Matsuyama
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002545:Brain Ischemia / Q000378:metabolism* / Q000473:pathology; D002540:Cerebral Cortex / Q000378:metabolism* / Q000473:pathology; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D016513:Mice, SCID; D058953:Neural Stem Cells / Q000378:metabolism* / Q000473:pathology; D055495:Neurogenesis / Q000502:physiology*; D061251:Primary Cell Culture; D017966:Pyramidal Cells / Q000378:metabolism* / Q000473:pathology
chemical_list: D015415:Biomarkers