title: Nanocomposite biomaterial mimicking aortic heart valve leaflet mechanical behaviour.
abstract: The main problem with polymeric heart valves (which are already biocompatible) is that they usually fail in the long term owing to tearing and calcification of the leaflets under high dynamic tensile bending stress and oxidative reactions with blood. To overcome this shortcoming, it is hypothesized that synthetic valve leaflets which mimic native valve leaflet structure fabricated from fibre-reinforced composite material will optimize leaflet stresses and decrease tears and perforations. The objective of this study is to develop a PVA-BC (polyvinyl alcohol-bacterial cellulose)-based hydrogel that mimics not only the non-linear mechanical properties displayed by porcine heart valves, but also their anisotropic behaviour. By applying a controlled strain to the PVA samples, while undergoing low-temperature thermal cycling, it was possible to create oriented mechanical properties in PVA hydrogels. The oriented stress-strain properties of porcine aortic valves were matched simultaneously by a PVA hydrogel (15 per cent PVA, 0.5 BC cycle 4, 75 per cent initial tensile strain). This novel technique allows the control of anisotropy to PVA hydrogel, and gives a broad range of control of its mechanical properties, for specific medical device applications.
authors.affiliation: The Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. hadim74@gmail.com
authors.forename: H
authors.initials: H
authors.lastname: Mohammadi
mesh_terms: D000818:Animals; D016880:Anisotropy; D001021:Aortic Valve / Q000502:physiology* / Q000601:surgery*; D001696:Biomechanical Phenomena; D001705:Bioprosthesis; D002482:Cellulose; D019544:Equipment Failure Analysis; D006350:Heart Valve Prosthesis; D006801:Humans; D008422:Materials Testing; D053761:Nanocomposites / Q000737:chemistry; D011142:Polyvinyl Alcohol; D013552:Swine; D013718:Tensile Strength
chemical_list: D011142:Polyvinyl Alcohol; D002482:Cellulose