title: A mathematical model of cell death in multiple sclerosis.
abstract: This paper imparts a mathematical model of multiple sclerosis (MS) that was created using Biochemical Systems Theory (BST). This method uses mechanisms and initial values from the literature to create a mathematical model of a disease. The model can then be used to test potential drug therapies and to detect possible trigger points for the disease. The focus of this MS model is mainly the action of reactive oxygen and nitrogen species (RONS), the permeability transition pore (PTP), apoptotic factors, and the eventual cell death in the oligodendrocyte. Several treatment methods were applied based on current therapies; however, one treatment, the prevention of the PTP from opening, is completely experimental and showed positive results based on this model. BST is an effective means of studying MS and can be beneficial in testing new therapy ideas.
authors.affiliation: Department of Chemistry Integrated Science Center, 540 Landrum Drive, The College of William and Mary, Williamsburg, VA 23187, USA.
authors.forename: Taylor M
authors.initials: TM
authors.lastname: Broome
authors.forename: Randolph A
authors.initials: RA
authors.lastname: Coleman
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D051017:Apoptosis Regulatory Proteins / Q000502:physiology; D016923:Cell Death / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000473:pathology; D033681:Mitochondrial Membrane Transport Proteins / Q000502:physiology; D000083162:Mitochondrial Permeability Transition Pore; D008959:Models, Neurological; D009103:Multiple Sclerosis / Q000378:metabolism / Q000473:pathology*; D009186:Myelin Sheath / Q000502:physiology; D009836:Oligodendroglia / Q000502:physiology; D018384:Oxidative Stress / Q000502:physiology*; D026361:Reactive Nitrogen Species / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: D051017:Apoptosis Regulatory Proteins; D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species