title: [Inflammatory factors promote the development of colorectal cancer].
abstract: OBJECTIVE
  To study the change of inflammatory factors at different stages of colorectal cancer (CRC).
  
  
  METHODS
  Thirty normal subjects, 30 patients with colorectal adenomatous polyps and 120 CRC patients at different stages were enrolled. IgG, IgM, and IgA levels, the inflammatory cytokines IL-2, 4, 6, 10, and 12 and the expression of TGF-β 1 and VEGF in the serum were analyzed by ELISA or immunoturbidimetry.
  
  
  RESULTS
  The serum concentrations of IL-12, TGF-β 1, and IL-6 in the CRC patients were statistically different compared with the normal and adenomatous polyps, and increased as the disease progressed (P<0.05). IL-6 reached the highest level in C phase of CRC.The serum concentrations of IL-2, IL-4, and IL-10 were significantly different among the groups. VEGF serum levels in CRC Phase A and Phase B compared with other groups were statistically different, but other serum concentrations had no significant difference (P>0.05). The serum level of IgG, IgM, and IgA in the 3 groups showed no significant difference (P>0.05).
  
  
  CONCLUSIONS
  The serum level of inflammatory cytokines TGF-β 1, IL-6, and IL-12 increases gradually with the development of CRC, which may change the microcirculation of patients with CRC, and promote the development of CRC.
authors.affiliation: Department of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Guo
authors.forename: Shourong
authors.initials: S
authors.lastname: Shen
authors.forename: Xiayu
authors.initials: X
authors.lastname: Li
authors.forename: Ke
authors.initials: K
authors.lastname: Tang
authors.forename: Weiwei
authors.initials: W
authors.lastname: Zhou
mesh_terms: D018256:Adenomatous Polyps / Q000097:blood; D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000097:blood* / Q000276:immunology; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000097:blood*; D007249:Inflammation; D018664:Interleukin-12 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D053773:Transforming Growth Factor beta1 / Q000097:blood
chemical_list: D016207:Cytokines; D007136:Immunoglobulins; D015850:Interleukin-6; D053773:Transforming Growth Factor beta1; D018664:Interleukin-12