title: Incremental diagnostic value of regional myocardial blood flow quantification over relative perfusion imaging with generator-produced rubidium-82 PET.
abstract: BACKGROUND
  Myocardial blood flow (MBF) can be measured with positron emission tomography (PET) and its quantification should provide diagnostic information beyond that obtained through standard visual analysis. However, this possibility has not been fully studied with PET and generator-produced rubidium-82 (⁸²Rb). We evaluated regional MBF in segments with and without ischemia using ⁸²Rb PET in patients with coronary artery disease (CAD).
  
  
  RESULTS
  Rest and stress ⁸²Rb PET and coronary angiography were performed for 12 patients with CAD. Based on angiography and relative ⁸²Rb perfusion images, segments were classified into 4 groups (Group A: myocardial ischemia with >70% diameter stenosis; Group B: no ischemia with stenosis; Group C: no ischemia without stenosis; Group D: ischemia without stenosis). Rest MBF was similar among the 4 groups. Groups A and B showed reduced hyperemic MBF compared with Group C (P < 0.05 vs. Group C) [Group A (n=16) 1.28 ± 0.58 ml·min⁻¹·g⁻¹; Group B (n=11) 1.72 ± 0.64 ml·min⁻¹·g⁻¹; Group C (n=9) 2.60 ± 1.09 ml·min⁻¹·g⁻¹; Group D (n=2) 2.33 ml·min⁻¹·g⁻¹]. Coronary flow reserves were inversely correlated with percent diameter stenosis (r=0.76, P < 0.0001).
  
  
  CONCLUSIONS
  Segments with ischemia and coronary stenosis had reduced hyperemic MBF. Segments with coronary stenosis without ischemia also had reduced hyperemic MBF compared with non-stenotic segments. MBF quantification using ⁸²Rb PET may provide additional diagnostic information.
authors.affiliation: Department of Photobiology, Hokkaido University Graduate School of Medicine, Japan. kyoshi@med.hokudai.ac.jp
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Yoshinaga
authors.forename: Chietsugu
authors.initials: C
authors.lastname: Katoh
authors.forename: Osamu
authors.initials: O
authors.lastname: Manabe
authors.forename: Ran
authors.initials: R
authors.lastname: Klein
authors.forename: Masanao
authors.initials: M
authors.lastname: Naya
authors.forename: Mamoru
authors.initials: M
authors.lastname: Sakakibara
authors.forename: Shiro
authors.initials: S
authors.lastname: Yamada
authors.forename: Robert A
authors.initials: RA
authors.lastname: Dekemp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsutsui
authors.forename: Nagara
authors.initials: N
authors.lastname: Tamaki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000503:physiopathology; D003331:Coronary Vessels / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D009206:Myocardium; D049268:Positron-Emission Tomography / Q000379:methods*; D012039:Regional Blood Flow; D012414:Rubidium Radioisotopes
chemical_list: D012414:Rubidium Radioisotopes