title: Serum osteocalcin levels in patients with nonalcoholic fatty liver disease: association with ballooning degeneration.
abstract: Our aim was to examine the relation of serum osteocalcin (OCN) levels with the clinical, biochemical, and histological characteristics of patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD). We carried out a case-control study including 99 patients with biopsy-proven NAFLD and 75 age- and sex-matched controls. Concentrations of OCN were measured in aprotinin-treated serum samples using a solid-phase enzyme amplified sensitivity immunoassay. Serum OCN levels were significantly lower in patients with NAFLD than in healthy controls. In patients with NAFLD, serum OCN levels were inversely associated with ALT (r = -0.36, p < 0.001), AST (r =-0.39, p < 0.001), HOMA-IR (r = -0.30, p < 0.01) and the degree of hepatocyte ballooning (r =-0.20, p < 0.05). Serum OCN was the only independent predictor of the degree of hepatocyte ballooning in NAFLD patients (β = -0.24; t = -2.146, p < 0.05). Compared with controls, NAFLD patients have a decrease in serum OCN concentrations, which is significantly associated with serum transaminases and the extent of hepatocyte ballooning.
authors.affiliation: Department of Gastroenterology, Marmara University, School of Medicine, Istanbul. yusufyilmaz@uludag.edu.tr
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Yilmaz
authors.forename: Ramazan
authors.initials: R
authors.lastname: Kurt
authors.forename: Fatih
authors.initials: F
authors.lastname: Eren
authors.forename: Nese
authors.initials: N
authors.lastname: Imeryuz
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood*; D007611:Aprotinin / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D016022:Case-Control Studies; D005234:Fatty Liver / Q000097:blood* / Q000201:enzymology* / Q000473:pathology; D005260:Female; D022781:Hepatocytes / Q000201:enzymology* / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D007118:Immunoassay; D008099:Liver / Q000201:enzymology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease; D015675:Osteocalcin / Q000097:blood*; D014421:Turkey
chemical_list: D015415:Biomarkers; D015675:Osteocalcin; D007611:Aprotinin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase