title: Screening of immigrants in the UK for latent tuberculosis.
abstract: Evaluation of: Pareek M, Watson JP, Ormerod LP et al. Screening of immigrants in the UK for imported latent tuberculosis: a multicentre cohort study and cost-effectiveness analysis. Lancet Infect. Dis. 11(6), 435-444 (2011).Tuberculosis (TB) is a serious public health problem in the UK, and detection and prophylactic treatment of latent infection offers improved control. A recent study advocates the use of IFN-γ release assays to detect latent TB infection in immigrants to the UK under 35 years of age and suggests that such a program would be most cost effective if targeted at new entrants from high burden countries. We discuss these findings in the light of recently updated UK and European guidelines. We conclude that while action to contain TB in the UK is urgently needed, further evidence is required to assess the impact and cost-effectiveness of screening algorithms for latent infection.
authors.affiliation: Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK. ruth.mcnerney@lshtm.ac.uk
authors.forename: Ruth
authors.initials: R
authors.lastname: McNerney
authors.forename: Giovanni
authors.initials: G
authors.lastname: Ferrara
authors.forename: Justin
authors.initials: J
authors.lastname: O'Grady
authors.forename: Markus
authors.initials: M
authors.lastname: Maeurer
authors.forename: Alimuddin
authors.initials: A
authors.lastname: Zumla