title: Factors and outcomes of decision making for cancer clinical trial participation.
abstract: OBJECTIVE
  To describe factors and outcomes related to the decision-making process regarding participation in a cancer clinical trial.
  
  
  METHODS
  Cross-sectional, descriptive.
  
  
  METHODS
  Urban, academic, National Cancer Institute-designated comprehensive cancer center in the mid-Atlantic United States.
  
  
  METHODS
  197 patients with advanced gastrointestinal cancer.
  
  
  METHODS
  Mailed survey using one investigator-developed instrument, eight instruments used in published research, and a medical record review.
  
  
  METHODS
  
  
  
  METHODS
  disease context, sociodemographics, hope, quality of life, trust in healthcare system, trust in health professional, preference for research decision control, understanding risks, and information.
  
  
  METHODS
  decision to accept or decline research participation and satisfaction with this decision.
  
  
  RESULTS
  All of the factors within the Research Decision Making Model together predicted cancer clinical trial participation and satisfaction with this decision. The most frequently preferred decision-making style for research participation was shared (collaborative) (83%).
  
  
  CONCLUSIONS
  Multiple factors affect decision making for cancer clinical trial participation and satisfaction with this decision. Shared decision making previously was an unrecognized factor and requires further investigation.
  
  
  CONCLUSIONS
  Enhancing the process of research decision making may facilitate an increase in cancer clinical trial enrollment rates. Oncology nurses have unique opportunities as educators and researchers to support shared decision making by those who prefer this method for deciding whether to accept or decline cancer clinical trial participation.
authors.affiliation: Skip Viragh Center for Pancreas Cancer Clinical Research and Patient Care, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins, Baltimore, MD, USA. NPBiedrzycki@aol.com
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Biedrzycki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002986:Clinical Trials as Topic; D003430:Cross-Sectional Studies; D003657:Decision Making; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010358:Patient Participation / Q000523:psychology* / Q000706:statistics & numerical data; D017060:Patient Satisfaction / Q000706:statistics & numerical data