title: Optimal duration of a sustained inflation recruitment maneuver in ARDS patients.
abstract: OBJECTIVE
  To measure the dynamics of recruitment and the hemodynamic status during a sustained inflation recruitment maneuver (RM) in order to determine the optimal duration of RM in acute respiratory distress syndrome (ARDS) patients.
  
  
  METHODS
  This prospective study was conducted in a 12-bed intensive care unit (ICU) in a general hospital. A 40 cmH(2)O sustained inflation RM maintained for 30 s was performed in 50 sedated ventilated patients within the first 24 h of meeting ARDS criteria. Invasive arterial pressures, heart rate, and SpO(2) were measured at 10-s intervals during the RM. The volume increase during the RM was measured by integration of the flow required to maintain the pressure at 40 cmH(2)O, which provides an estimation of the volume recruited during the RM. Raw data were corrected for gas consumption and fitted with an exponential curve in order to determine an individual time constant for the volume increase.
  
  
  RESULTS
  The average volume increase and time constant were 210 ± 198 mL and 2.3 ± 1.3 s, respectively. Heart rate, diastolic arterial pressure, and SpO(2) did not change during or after the RM. Systolic and mean arterial pressures were maintained at 10 s, decreased significantly at 20 and 30 s during the RM, and recovered to the pre-RM value 30 s after the end of the RM (ANOVA, p < 0.01).
  
  
  CONCLUSIONS
  In early-onset ARDS patients, most of the recruitment occurs during the first 10 s of a sustained inflation RM. However, hemodynamic impairment is significant after the tenth second of RM.
authors.affiliation: Service de Réanimation Polyvalente, Hôpital Font Pré, 1208 Avenue du Colonel Picot, 83100 Toulon, France. jean-michel@arnal.org
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Arnal
authors.forename: Jérémie
authors.initials: J
authors.lastname: Paquet
authors.forename: Marc
authors.initials: M
authors.lastname: Wysocki
authors.forename: Didier
authors.initials: D
authors.lastname: Demory
authors.forename: Stéphane
authors.initials: S
authors.lastname: Donati
authors.forename: Isabelle
authors.initials: I
authors.lastname: Granier
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Corno
authors.forename: Jacques
authors.initials: J
authors.lastname: Durand-Gasselin
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011175:Positive-Pressure Respiration / Q000379:methods*; D011446:Prospective Studies; D012128:Respiratory Distress Syndrome / Q000503:physiopathology / Q000628:therapy*; D012129:Respiratory Function Tests; D013997:Time Factors