title: Arterial ischemic stroke in an adolescent with presumed perinatal ischemic stroke.
abstract: The risk of recurrent ischemic stroke after presumed perinatal stroke and the risk factors for such recurrence are rarely reported. Here, we present an adolescent with a history of presumed perinatal stroke who presented with arterial ischemic stroke recurrence at the age of 15 years. Hereditary thrombophilia screening performed at the time of his stroke recurrence demonstrated protein S deficiency. No evidence-based consensus guidelines on thrombophilia screening in children with presumed perinatal stroke exist, nor has the role of secondary prophylaxis been addressed. There is a risk of stroke recurrence after presumed perinatal stroke, and routine thrombophilia screening may identify those children who are at higher risk for recurrence and who might therefore benefit from secondary prophylaxis. Clear guidelines should be developed to standardize investigations and management of children with presumed perinatal ischemic stroke.
authors.affiliation: Section of Pediatric Neurology, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada.
authors.forename: Kristin
authors.initials: K
authors.lastname: Hamilton
authors.forename: Michael S
authors.initials: MS
authors.lastname: Salman
authors.forename: Ilan
authors.initials: I
authors.lastname: Schwartz
authors.forename: Patricia J
authors.initials: PJ
authors.lastname: McCusker
authors.forename: Jens
authors.initials: J
authors.lastname: Wrogemann
authors.forename: Mubeen F
authors.initials: MF
authors.lastname: Rafay
mesh_terms: D000293:Adolescent; D002533:Cerebral Angiography; D005165:Factor V / Q000235:genetics; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000150:complications* / Q000235:genetics; D008297:Male; D009154:Mutation / Q000235:genetics; D020521:Stroke / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: C095381:factor V Leiden; D005165:Factor V