title: Small peripheral lung carcinomas with five-year post-surgical follow-up: assessment by semi-automated volumetric measurement of tumour size, CT value and growth rate on TSCT.
abstract: OBJECTIVE
  To retrospectively assess the utility of semi-automated measurements by stratification of CT values of tumour size, CT value and doubling time (DT) using thin-section computed tomography (CT) images. The post-surgical outcomes of favourable and problematic tumours (more advanced p stage than IA, post-surgical recurrence or mortality from lung cancer) were compared using the measured values. The computed DTs were compared with manually measured values.
  
  
  METHODS
  The study subjects comprised 85 patients (aged 33-80 years, 48 women, 37 men), followed-up for more than 5 years postoperatively, with 89 lung lesions, including 17 atypical adenomatous hyperplasias and 72 lung cancers. DTs were determined in 45 lesions.
  
  
  RESULTS
  For problematic lesions, whole tumour diameter and density were >18 mm and >-400 HU, respectively. The respective values for the tumour core (with CT values of -350 to 150 HU) were >15 mm and >-70 HU. Analysis of tumour core DTs showed interval tumour progression even if little progress was seen by standard tumour volume DT (TVDT).
  
  
  CONCLUSIONS
  Software-based volumetric measurements by stratification of CT values provide valuable information on tumour core and help estimate tumour aggressiveness and interval tumour progression better than standard manually measured 2D-VDTs.
authors.affiliation: JA Nagano Azumi General Hospital, Ikeda, Nagano, Japan. shu_sones_37@ybb.ne.jp
authors.forename: Shusuke
authors.initials: S
authors.lastname: Sone
authors.forename: Takaomi
authors.initials: T
authors.lastname: Hanaoka
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ogata
authors.forename: Fumiyoshi
authors.initials: F
authors.lastname: Takayama
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Watanabe
authors.forename: Masayuki
authors.initials: M
authors.lastname: Haniuda
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kaneko
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Kondo
authors.forename: Kazuo
authors.initials: K
authors.lastname: Yoshida
authors.forename: Takayuki
authors.initials: T
authors.lastname: Honda
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000401:mortality / Q000473:pathology*; D000077192:Adenocarcinoma of Lung; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011829:Radiation Dosage; D011856:Radiographic Image Enhancement; D013902:Radiography, Thoracic; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012907:Smoking / Q000009:adverse effects; D013908:Thoracotomy / Q000401:mortality; D014057:Tomography, X-Ray Computed; D047368:Tumor Burden