title: Efficacy of paroxetine in primary palmoplantar hyperhidrosis occurring with juvenile myoclonic epilepsy.
abstract: Primary palmoplantar hyperhidrosis (PPH) is believed to be a dysfunction of emotional sweating, with an estimated prevalence of around 3%. Several treatment options including topical antiperspirants, tap water iontophoresis, botulinum toxin injections, oral anticholinergics, and tricyclic antidepressants are available, each with a significant adverse event profile. For the first time, we report a PPH patient with comorbid juvenile myoclonic epilepsy (JME) treated successfully with a combination of paroxetine and divalproex sodium. Paroxetine resulted in improvement in PPH, possibly through its anticholinergic and/or noradrenergic actions. Though the occurrence of PPH and JME together seems to be a chance association, some common frontal lobe mechanisms may be involved that need to be explored further.
authors.affiliation: School of Psychology, Bangor University, Bangor, UK. drziaulhaq @ gmail.com
authors.forename: Mohammad Zia Ul Haq
authors.initials: MZ
authors.lastname: Katshu
authors.forename: Arnab
authors.initials: A
authors.lastname: Bhattacharya
authors.forename: S Haque
authors.initials: SH
authors.lastname: Nizamie
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006225:Hand; D006801:Humans; D006945:Hyperhidrosis / Q000188:drug therapy*; D020190:Myoclonic Epilepsy, Juvenile / Q000188:drug therapy*; D017374:Paroxetine / Q000627:therapeutic use*; D011788:Quality of Life; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D016896:Treatment Outcome; D014635:Valproic Acid / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors; D014635:Valproic Acid