title: [Relationship between magnesium concentration in cerebrospinal fluid and delayed cerebral ischemia in patients with aneurysmal subarachnoid hemorrhage].
abstract: BACKGROUND
  The present study was conducted to determine the relationship between magnesium concentration in cerebrospinal fluid (CSF) and delayed cerebral ischemia (DCI) in patients with subarachnoid hemorrhage (SAH).
  
  
  METHODS
  We studied 39 consecutive patients undergoing surgery after SAH. A spinal drainage catheter was inserted into the lower lumbar vertebrae before surgery. CSF was then sampled and the magnesium concentration measured. General clinical data, Hunt-Hess (H-H) grade and Fisher grade, aneurysm size and site, intracerebral and intraventricular hemorrhage, and blood glucose levels were all recorded on admission. At the same time, the Glasgow coma scale (GCS) score was calculated. Outcomes were assessed using the Glasgow outcome scale at discharge. DCI was defined as a two-point decrease in the GCS score and/or focal deficit, and was confirmed by cerebral angiography. The recorded values were expressed as the median (interquartile range).
  
  
  RESULTS
  Of the 39 patients, 23 (59%) had DCI. The magnesium concentration in the DCI cases was 2.8 (2.7 and 2.9) mg x dl(-1), which was significantly lower than that in the non-DCI cases, i. e., 2.9 (2.8 and 3.0) mg x dl(-1) (P < 0.05). There were no significant differences in the other factors.
  
  
  CONCLUSIONS
  The results indicate that preoperative hypomagnesemia within the CSF might play a role in the development of DCI in patients with SAH; however, further studies will be necessary to confirm this observation.
authors.affiliation: Department of Anesthesia, Nagasaki Rosai Hospital, Nagasaki 857-0134.
authors.forename: Taiga
authors.initials: T
authors.lastname: Ichinomiya
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Terao
authors.forename: Tomomi
authors.initials: T
authors.lastname: Tanise
authors.forename: Ushio
authors.initials: U
authors.lastname: Higashijima
authors.forename: Kosuke
authors.initials: K
authors.lastname: Miura
authors.forename: Makoto
authors.initials: M
authors.lastname: Fukusaki
authors.forename: Koji
authors.initials: K
authors.lastname: Sumikawa
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000134:cerebrospinal fluid; D002545:Brain Ischemia / Q000209:etiology*; D005260:Female; D006801:Humans; D053565:Hypercalciuria / Q000150:complications* / Q000175:diagnosis*; D008274:Magnesium / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D009397:Nephrocalcinosis / Q000150:complications* / Q000175:diagnosis*; D057234:Preoperative Period; D015499:Renal Tubular Transport, Inborn Errors / Q000150:complications* / Q000175:diagnosis*; D013345:Subarachnoid Hemorrhage / Q000150:complications* / Q000601:surgery
chemical_list: D015415:Biomarkers; D008274:Magnesium