title: Plasma substance P level in patients with schizophrenia: a cross-sectional study.
abstract: Aspiration pneumonia is a serious health concern in older patients with schizophrenia. In this study, we examined clinical and demographic variables that could impact the plasma substance P level, which is a useful predictive biomarker of aspiration. Thirty-four patients were included (mean age ± SD: 70.9 ± 10.8 years). A greater number of cigarettes/day and a higher antipsychotic dosage were found to be associated with a lower plasma substance P level, while age showed a trend-level effect. This finding suggests the need for intensive observation for prevention of aspiration pneumonia in heavy smokers who are receiving a higher antipsychotic dose in this senior population.
authors.affiliation: Department of Psychiatry, Sakuragaoka Memorial Hospital, Tokyo, Japan. t_ishi_2750@yahoo.co.jp
authors.forename: Takuto
authors.initials: T
authors.lastname: Ishida
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Uchida
authors.forename: Takefumi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Nakajima
authors.forename: Koichiro
authors.initials: K
authors.lastname: Watanabe
authors.forename: Haruo
authors.initials: H
authors.lastname: Kashima
mesh_terms: D000368:Aged; D014150:Antipsychotic Agents / Q000494:pharmacology / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D004305:Dose-Response Relationship, Drug; D006801:Humans; D011015:Pneumonia, Aspiration / Q000517:prevention & control; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy; D012907:Smoking / Q000097:blood; D013373:Substance P / Q000097:blood*
chemical_list: D014150:Antipsychotic Agents; D015415:Biomarkers; D013373:Substance P