title: Synthesis of (-)-arctigenin derivatives and their anticancer activity.
abstract: The natural dibenzylbutyrolactone type lignanolide (-)-arctigenin, which was prepared from fructus arctii, showed obvious anticancer activity. The synthesis of four new (-)-arctigenin derivatives and their anticancer bioactivities were examined. The structures of the four new synthetic derivatives were elucidated.
authors.affiliation: College of pharmacy, Liaoning University of Traditional Chinese Medicine, 77 Life one Road, DD port, Dalian 116600, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Gui-Rong
authors.forename: Cai
authors.initials: C
authors.lastname: Li-Ping
authors.forename: Dou
authors.initials: D
authors.lastname: De-Qiang
authors.forename: Kang
authors.initials: K
authors.lastname: Ting-Guo
authors.forename: Li
authors.initials: L
authors.lastname: Hong-Fu
authors.forename: Li
authors.initials: L
authors.lastname: Fu-Rui
authors.forename: Jiang
authors.initials: J
authors.lastname: Ning
mesh_terms: D000478:Alkylation; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D031170:Arctium / Q000737:chemistry*; D002082:Butylamines / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005021:Ethylamines / Q000737:chemistry; D005638:Fruit / Q000737:chemistry*; D005663:Furans / Q000032:analysis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D017705:Lignans / Q000032:analysis* / Q000737:chemistry / Q000494:pharmacology; D008744:Methylamines / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D002082:Butylamines; D005021:Ethylamines; D005663:Furans; D017705:Lignans; D008744:Methylamines; C027451:methylamine; C071942:arctigenin; C041564:ethylamine