title: Performances on the CogState and standard neuropsychological batteries among HIV patients without dementia.
abstract: HIV-associated neurocognitive disorders remain prevalent but challenging to diagnose particularly among non-demented individuals. To determine whether a brief computerized battery correlates with formal neurocognitive testing, we identified 46 HIV-infected persons who had undergone both formal neurocognitive testing and a brief computerized battery. Simple detection tests correlated best with formal neuropsychological testing. By multivariable regression model, 53% of the variance in the composite Global Deficit Score was accounted for by elements from the brief computerized tool (P < 0.01). These data confirm previous correlation data with the computerized battery. Using the five significant parameters from the regression model in a Receiver Operating Characteristic curve, 90% of persons were accurately classified as being cognitively impaired or not. The test battery requires additional evaluation, specifically for identifying persons with mild impairment, a state upon which interventions may be effective.
authors.affiliation: Washington University School of Medicine, St Louis, MO, USA. toverton@dom.wustl.edu
authors.forename: Edgar Turner
authors.initials: ET
authors.lastname: Overton
authors.forename: John S K
authors.initials: JS
authors.lastname: Kauwe
authors.forename: Robert
authors.initials: R
authors.lastname: Paul
authors.forename: Karen
authors.initials: K
authors.lastname: Tashima
authors.forename: David F
authors.initials: DF
authors.lastname: Tate
authors.forename: Pragna
authors.initials: P
authors.lastname: Patel
authors.forename: Charles C J
authors.initials: CC
authors.lastname: Carpenter
authors.forename: David
authors.initials: D
authors.lastname: Patty
authors.forename: John T
authors.initials: JT
authors.lastname: Brooks
authors.forename: David B
authors.initials: DB
authors.lastname: Clifford
mesh_terms: D000328:Adult; D018791:CD4 Lymphocyte Count; D003072:Cognition Disorders / Q000175:diagnosis* / Q000523:psychology; D015331:Cohort Studies; D003704:Dementia / Q000523:psychology; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D011594:Psychometrics; D012372:ROC Curve; D012044:Regression Analysis; D015203:Reproducibility of Results; D012959:Socioeconomic Factors; D019562:Viral Load; D055815:Young Adult