title: A melanin-inspired pro-oxidant system for dopa(mine) polymerization: mimicking the natural casing process.
abstract: An oxygen-dependent biomimetic system for DOPA, dopamine and norepinephrine polymerization exploiting the redox properties of a 5-S-cysteinylDOPA (CD)-melanin polymer is disclosed. Kinetic, chemical and scanning electron microscopy (SEM) evidence indicates conversion of DOPA into a black insoluble polymer encapsulating the active CD-melanin core.
authors.affiliation: Department of Organic Chemistry and Biochemistry, University of Naples Federico II, via Cinthia 4, I-80126, Naples, Italy.
authors.forename: Giorgia
authors.initials: G
authors.lastname: Greco
authors.forename: Lucia
authors.initials: L
authors.lastname: Panzella
authors.forename: Gennaro
authors.initials: G
authors.lastname: Gentile
authors.forename: Maria Emanuela
authors.initials: ME
authors.lastname: Errico
authors.forename: Cosimo
authors.initials: C
authors.lastname: Carfagna
authors.forename: Alessandra
authors.initials: A
authors.lastname: Napolitano
authors.forename: Marco
authors.initials: M
authors.lastname: d'Ischia
mesh_terms: D032701:Biomimetics; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives / Q000737:chemistry*; D004298:Dopamine / Q000737:chemistry* / Q000378:metabolism; D007700:Kinetics; D008543:Melanins / Q000737:chemistry* / Q000378:metabolism*; D020460:Melanosomes / Q000378:metabolism; D058105:Polymerization; D017382:Reactive Oxygen Species / Q000737:chemistry* / Q000378:metabolism
chemical_list: C092922:5-S-cysteinyl-3,4-dihydroxyphenylalanine; D008543:Melanins; D017382:Reactive Oxygen Species; D004295:Dihydroxyphenylalanine; D004298:Dopamine