title: Biliary excretion of essential trace elements in rats under oxidative stress caused by selenium deficiency.
abstract: The excretion of essential trace elements, namely, Se, Sr, As, Mn, Co, V, Fe, and Zn into the bile of Se-deficient (SeD) Wistar male rats was studied using the multitracer (MT) technique, and instrumental neutron activation analysis (INAA). Normal and Se-control (SeC) rat groups were used as reference groups to compare the effects of Se levels on the behaviors of the essential trace elements. The excretion (% dose) of Se, Sr, As, Mn, Co, and V increased with Se levels in the liver. The biliary excretion of Mn and As dramatically enhanced for SeC rats compared with SeD rats, while that of V accelerated a little for SeC rats. The radioactivity levels of (59)Fe and (65)Zn in the MT tracer solution were insufficient to measure their excretion into bile. The role of glutathione and bilirubin for biliary excretion of the metals was discussed in relation to Se levels in rat liver.
authors.affiliation: School of Agriculture, Meiji University, 1-1-1 Higashi-Mita, Tama-ku, Kawasaki, Kanagawa 214-8571, Japan.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Yamasaki
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Sakuma
authors.forename: Junya
authors.initials: J
authors.lastname: Sasaki
authors.forename: Ken-ichiro
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Kazunori
authors.initials: K
authors.lastname: Anzai
authors.forename: Keisuke
authors.initials: K
authors.lastname: Matsuoka
authors.forename: Chikako
authors.initials: C
authors.lastname: Honda
authors.forename: Masamichi
authors.initials: M
authors.lastname: Tsukada
authors.forename: Kazutoyo
authors.initials: K
authors.lastname: Endo
authors.forename: Shuichi
authors.initials: S
authors.lastname: Enomoto
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism*; D005260:Female; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009501:Neutron Activation Analysis; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000378:metabolism*; D014131:Trace Elements / Q000378:metabolism*
chemical_list: D014131:Trace Elements; D005978:Glutathione; D012643:Selenium