title: Effects of ranolazine on cardiovascular system.
abstract: Chronic stable angina affects 6-7 million Americans and contributes to a significant reduction in quality of life and life expectancy. Current pharmacotherapy for reducing episodes of exertional angina includes β-blockers, calcium channel blockers and long-acting nitrates. Patients may have contraindications to the use of one or more of these agents or be unable to tolerate initial or larger therapeutic doses. As a result of the inability of current management strategies to optimally control episodes of chronic angina, new therapies have been investigated that do not have some of the limitations of current therapies. New therapies for chronic stable angina are based on a mechanism involving membrane current such as the funny current and the late Na current. Ranolazine (Ran) is an antianginal drug acting on I(Na). After its current indication in the chronic stable angina, the role of this molecule is still being studied for prophylaxis of certain arrhythmias and treatment of heart failure. Moreover, have been recently developed new interesting patents of novel pharmaceutical effects and derivates of Ran.
authors.affiliation: Section of Cardiovascular diseases, Department of Experimental and Applied Medicine, University of Study of Brescia.
authors.forename: Ivano
authors.initials: I
authors.lastname: Bonadei
authors.forename: Enrico
authors.initials: E
authors.lastname: Vizzardi
authors.forename: Filippo
authors.initials: F
authors.lastname: Quinzani
authors.forename: Barbara
authors.initials: B
authors.lastname: Piovanelli
authors.forename: Riccardo
authors.initials: R
authors.lastname: Rovetta
authors.forename: Antonio
authors.initials: A
authors.lastname: D'Aloia
authors.forename: Livio D
authors.initials: LD
authors.lastname: Cas
mesh_terms: D000083:Acetanilides / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D000787:Angina Pectoris / Q000188:drug therapy* / Q000503:physiopathology; D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000503:physiopathology; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D010330:Patents as Topic; D010879:Piperazines / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D011788:Quality of Life; D000069458:Ranolazine; D014481:United States
chemical_list: D000083:Acetanilides; D004791:Enzyme Inhibitors; D010879:Piperazines; D000069458:Ranolazine