title: There is no association of CCR6 polymorphisms with susceptibility to Behcet's disease in two Chinese Han populations.
abstract: BACKGROUND
  Polymorphisms of CC chemokine receptor 6 (CCR6) genes have recently been reported to be associated with the susceptibility to several immune-related diseases. This study was conducted to examine the association of CCR6 with Behçet's disease (BD) in two Chinese Han populations.
  
  
  METHODS
  A total of 473 patients with BD and 725 healthy controls from two Chinese Han populations were genotyped by the PCR-restriction fragment length polymorphism method. Hardy-Weinberg equilibrium was tested using the χ(2) test. Genotype frequencies were estimated by direct counting. Allele and genotype frequencies were compared between patients and controls using the χ(2) test.
  
  
  RESULTS
  The genotype and allele frequencies of rs3093024, rs6902119, rs3093023 and rs2301436 were not different between patients with BD and healthy controls. Analysis according to gender and clinical findings including oral ulcer, genital ulcer, skin lesions and arthritis did not show any association of the four tested polymorphisms with these parameters.
  
  
  CONCLUSIONS
  The tested CCR6 gene polymorphisms are not associated with the susceptibility to BD in the tested Chinese Han populations.
authors.affiliation: The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, Chongqing, China.
authors.forename: Xianglong
authors.initials: X
authors.lastname: Yi
authors.forename: Peizeng
authors.initials: P
authors.lastname: Yang
authors.forename: Liping
authors.initials: L
authors.lastname: Du
authors.forename: Zhenxuan
authors.initials: Z
authors.lastname: Jiang
authors.forename: Fuzhen
authors.initials: F
authors.lastname: Li
mesh_terms: D000328:Adult; D017677:Age Distribution; D001528:Behcet Syndrome / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D054399:Receptors, CCR6 / Q000235:genetics*; D017678:Sex Distribution; D055815:Young Adult
chemical_list: C106311:CCR6 protein, human; D054399:Receptors, CCR6