title: Fuscoside E: a strong anti-inflammatory diterpene from Caribbean octocoral Eunicea fusca.
abstract: The screen of 10 soft coral extracts collected from the Colombian Caribbean Sea in the TPA-induced ear edema model allowed us to identify Eunicea fusca extract among others as an interesting source of active compounds. The new diterpene, fuscoside E (1), along with the known fuscoside B (2), fuscol (3), (+)-germacrene D (4) and a mixture of six sterols (5-10), were isolated from this soft coral. Their structures were elucidated by 1D and 2D NMR spectroscopy techniques. Fuscoside E (1) absolute stereochemistry was determined by chiroptical methods. Fuscoside E (1) and B (2) showed strong anti-inflammatory in the above mentioned bioassay. Additionally, fuscoside E (1) and the sterol mixture (5-10) presented antifouling activity against bacterial strains involved in surface colonization.
authors.affiliation: Departamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia, Bogotá AA 14490, Colombia.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Reina
authors.forename: Carlos
authors.initials: C
authors.lastname: Puentes
authors.forename: Juan
authors.initials: J
authors.lastname: Rojas
authors.forename: Josué
authors.initials: J
authors.lastname: García
authors.forename: Freddy A
authors.initials: FA
authors.lastname: Ramos
authors.forename: Leonardo
authors.initials: L
authors.lastname: Castellanos
authors.forename: Marcela
authors.initials: M
authors.lastname: Aragón
authors.forename: Luis F
authors.initials: LF
authors.lastname: Ospina
mesh_terms: D000818:Animals; D037421:Anthozoa; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001407:Bacillus / Q000187:drug effects; D001681:Biological Assay; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D017691:Caribbean Region; D004195:Disease Models, Animal; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D055808:Drug Discovery; D004353:Drug Evaluation, Preclinical; D004423:Ear; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D013237:Stereoisomerism; D014733:Vibrio / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001688:Biological Products; D004224:Diterpenes; D006027:Glycosides; C571362:fuscoside E