title: The effect of a single high dose of PGF2α administered to dairy cattle 3.5 days after ovulation on luteal function, morphology, and follicular dynamics.
abstract: A single treatment with PGF2α is assumed to have no luteolytic effect on cows with corpora lutea < 5 days old. The objective of this study was to determine the effect of a single high dose of PGF2α administered to dairy cattle on the morphology and function of the early CL. The study followed a crossover design with a treatment cycle in which 50 mg of dinoprost were administered 3.5 days postovulation and a control untreated cycle. Ultrasound examination and blood samples were performed during the two consecutive cycles. Corpus luteum (CL) diameter, progesterone concentration, and follicular dynamics characteristics were compared between control and treated cycles. Two of nine cows (22%) developed full luteolysis. The remaining seven cows (78%) had partial luteolysis with a decrease (P < 0.05) in progesterone concentration and CL diameter for two and 12 days post-treatment, respectively. The interovulatory interval of treated cycles (19.7 ± 2.4 days) was not different (P > 0.05) from that of controls (23.8 ± 0.9 days). The transient reduction in progesterone of cows with partial luteolysis had no effect on the proportion of cows with two or three follicular waves, follicle growth rate, or preovulatory diameter (P > 0.05). Two cows developed ovarian cystic degeneration during the PGF2α-induced cycle. In conclusion, the treatment of cows with a high dose of PGF2α 3.5 days postovulation induced some degree of luteolysis in all treated cows. This resulted in partial luteolysis in 78% of treated animals and in full luteolysis in the remaining 22%.
authors.affiliation: Departamento de Medicina y Cirugía Animal, Facultad de Veterinaria, Universidad CEU Cardenal Herrera, Moncada, Spain. juan.cuervo@uch.ceu.es
authors.forename: J
authors.initials: J
authors.lastname: Cuervo-Arango
authors.forename: E
authors.initials: E
authors.lastname: García-Roselló
authors.forename: A
authors.initials: A
authors.lastname: García-Muñoz
authors.forename: X
authors.initials: X
authors.lastname: Valldecabres-Torres
authors.forename: P
authors.initials: P
authors.lastname: Martínez-Ros
authors.forename: A
authors.initials: A
authors.lastname: González-Bulnes
mesh_terms: D000818:Animals; D000858:Anovulation / Q000453:epidemiology / Q000662:veterinary; D002417:Cattle / Q000502:physiology*; D003338:Corpus Luteum / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000187:drug effects*; D018592:Cross-Over Studies; D015237:Dinoprost / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D015994:Incidence; D003341:Luteolysis / Q000187:drug effects; D006080:Ovarian Follicle / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000502:physiology; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D013997:Time Factors; D014463:Ultrasonography
chemical_list: D011374:Progesterone; D015237:Dinoprost