title: Cardiac metastasis and hypertrophic osteoarthropathy in recurrent infantile fibrosarcoma.
abstract: Cardiac metastasis and hypertrophic osteoarthropathy are both quite rare. We describe a patient presenting with hypertrophic osteoarthropathy as the first symptom of recurrent infantile fibrosarcoma (IF). During surgical resection of lung metastasis, the patient suffered sudden cardiac arrest. Autopsy demonstrated a metastatic lesion in the intraventricular septum of the heart, which is previously undescribed in the literature. This case demonstrates that IF can be aggressive despite its more typical benign course.
authors.affiliation: Division of Pediatric Oncology, Department of Oncology, Johns Hopkins University, Baltimore, Maryland 21287, USA.
authors.forename: Nirali N
authors.initials: NN
authors.lastname: Shah
authors.forename: Mitchell R
authors.initials: MR
authors.lastname: Price
authors.forename: David M
authors.initials: DM
authors.lastname: Loeb
mesh_terms: D017809:Fatal Outcome; D005260:Female; D005354:Fibrosarcoma / Q000473:pathology* / Q000601:surgery; D006338:Heart Neoplasms / Q000473:pathology* / Q000556:secondary* / Q000601:surgery; D006801:Humans; D007223:Infant; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary / Q000601:surgery; D009362:Neoplasm Metastasis; D010004:Osteoarthropathy, Primary Hypertrophic / Q000150:complications* / Q000473:pathology* / Q000601:surgery