title: Pd-catalyzed C4-olefination of oxazoles via C-H bond activation: divergent synthesis of functionalized amino alcohol and amino acid derivatives.
abstract: A Pd-catalyzed C4-olefination of oxazoles via C-H bond activation under mild conditions was achieved. The reaction was shown to be general over a range of substrates. New protocols for the divergent transformation of these products to provide functionalized amino alcohol and amino acid derivatives have also been established.
authors.affiliation: Department of Chemistry, University of South Florida, 4202 East Fowler Avenue, Tampa, Florida 33620, USA.
authors.forename: Sunliang
authors.initials: S
authors.lastname: Cui
authors.forename: Lukasz
authors.initials: L
authors.lastname: Wojtas
authors.forename: Jon C
authors.initials: JC
authors.lastname: Antilla
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000596:Amino Acids / Q000138:chemical synthesis*; D000605:Amino Alcohols / Q000138:chemical synthesis*; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D000475:Alkenes; D000596:Amino Acids; D000605:Amino Alcohols; D010080:Oxazoles; D010165:Palladium; D002244:Carbon; D006859:Hydrogen