title: KRAS-induced actin-interacting protein: a potent target for obesity, diabetes and cancer.
abstract: KRAS-induced actin-interacting protein (KRAP) was originally identified as one of the genes deregulated in colorectal cancer. KRAP encodes a cytoplasmic protein associated with filamentous-actin (F-actin), and the amino acid sequences are highly conserved among KRAP orthologues from fish to mammalian species. We demonstrated that KRAP-deficient mice show altered whole-body energy metabolism and resistance to diet-induced obesity and diabetes. Although the precise mechanisms underlying the metabolic phenotypes in the KRAP-deficient mice remain unclear, KRAP is considered to be a target for metabolism-related diseases. Furthermore, several groups have reported that KRAP is a cancer-associated gene. Further studies on the molecular functions of KRAP in physiological tissues could provide a better understanding of various diseases, and opportunities for intervention in various human diseases. In this review, we summarize the current understanding of KRAP and the roles that it plays in a variety of diseases.
authors.affiliation: Department of Cell Biology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Fujimoto
authors.forename: Senji
authors.initials: S
authors.lastname: Shirasawa
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D045744:Cell Line, Tumor; D015179:Colorectal Neoplasms / Q000473:pathology; D003920:Diabetes Mellitus / Q000188:drug therapy*; D004734:Energy Metabolism / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008565:Membrane Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D051379:Mice; D008840:Microfilament Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy*; D009765:Obesity / Q000188:drug therapy* / Q000517:prevention & control; D009928:Organ Specificity; D010641:Phenotype; D010802:Phylogeny; D011518:Proto-Oncogene Proteins / Q000502:physiology; D016283:Proto-Oncogene Proteins p21(ras); D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D013851:Thinness / Q000235:genetics; D018631:ras Proteins / Q000502:physiology
chemical_list: C482653:ITPRID2 protein, human; C557477:KRAP protein, mouse; C117307:KRAS protein, human; D008565:Membrane Proteins; D008840:Microfilament Proteins; D011518:Proto-Oncogene Proteins; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins