title: Immune regulatory mechanisms in ANCA-associated vasculitides.
abstract: A group of primary vasculitides is associated with the presence of anti-neutrophil cytoplasmic autoantibodies (ANCA). In these diseases, the contribution of ANCA to disease pathogenesis has been studied extensively. Also, in patients with ANCA-associated vasculitides, the T lymphocyte compartment is dysregulated, as aberrant distribution and function of T cell subsets has been shown. In this review we will discuss the putative role of T lymphocytes in inflammation and granuloma formation, as well as the involvement of B cell compartments in the pathophysiology of ANCA-associated vasculitis.
authors.affiliation: Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, the Netherlands.
authors.forename: Nikola
authors.initials: N
authors.lastname: Lepse
authors.forename: Wayel H
authors.initials: WH
authors.lastname: Abdulahad
authors.forename: Cees G M
authors.initials: CG
authors.lastname: Kallenberg
authors.forename: Peter
authors.initials: P
authors.lastname: Heeringa
mesh_terms: D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000150:complications / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology / Q000378:metabolism*; D060151:B-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism; D000939:Epitopes; D006099:Granuloma / Q000150:complications / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D009504:Neutrophils / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D000939:Epitopes