title: Bacterial L-arabinose isomerases: industrial application for D-tagatose production.
abstract: D-tagatose is a natural monosaccharide with a low caloric value and has an anti-hyperglycemiant effect. This hexose has potential applications both in pharmaceutical and agro-food industries. However, the use of D-tagatose remains limited by its production cost. Many production procedures including chemical and biological processes were developed and patented. The most profitable production way is based on the use of L-arabinose isomerase which allows the manufacture of D-tagatose with an attractive rate. Future developments are focused on the generation of L-arabinose isomerases having biochemical properties satisfying the industrial applications. This report provides a brief review of the most recent patents that have been published relating to this area.
authors.affiliation: Laboratory for Biocrystallography and Structural Biology of Therapeutical Targets, BMSSI- Institut de Biologie et Chimie des Proteines, UMR 5086-CNRS/Universite de Lyon, FR3302 BioSciences Gerland - Lyon Sud, F-69367 Lyon cedex 07, France.
authors.forename: Samira
authors.initials: S
authors.lastname: Boudebbouze
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Maguin
authors.forename: Moez
authors.initials: M
authors.lastname: Rhimi
mesh_terms: D019747:Aldose-Ketose Isomerases / Q000737:chemistry; D001426:Bacterial Proteins / Q000096:biosynthesis* / Q000235:genetics; D001709:Biotechnology / Q000331:legislation & jurisprudence* / Q000379:methods; D006601:Hexoses / Q000096:biosynthesis*; D007218:Industrial Microbiology / Q000331:legislation & jurisprudence* / Q000379:methods; D010330:Patents as Topic; D015202:Protein Engineering / Q000331:legislation & jurisprudence / Q000379:methods; D014481:United States
chemical_list: D001426:Bacterial Proteins; D006601:Hexoses; D019747:Aldose-Ketose Isomerases; C019715:L-arabinose isomerase; C030192:tagatose