title: Glucagonoma syndrome: a case report.
abstract: BACKGROUND
  Glucagonoma syndrome is a rare paraneoplastic phenomenon, with an estimated incidence of one in 20 million, characterized by necrolytic migratory erythema, hyperglucagonemia, diabetes mellitus, anemia, weight loss, glossitis, cheilitis, steatorrhea, diarrhea, venous thrombosis and neuropsychiatric disturbances in the setting of a glucagon-producing alpha-cell tumor of the pancreas. Necrolytic migratory erythema is the presenting manifestation in the majority of cases, so its early suspicion and correct diagnosis is a key factor in the management of the patient.
  
  
  METHODS
  We present the case of a 70-year-old Caucasian woman with glucagonoma syndrome due to an alpha-cell tumor located in the tail of the pancreas, successfully treated with surgical resection.
  
  
  CONCLUSIONS
  Clinicians should be aware of the unusual initial manifestations of glucagonoma. Early diagnosis allows complete surgical resection of the neoplasm and provides the only chance of a cure.
authors.affiliation: Department of General Surgery and Gastroenterology, Hospital Universitario Central de Asturias, Oviedo, Spain. pgranerocastro@aecirujanos.es.
authors.forename: Pablo Granero
authors.initials: PG
authors.lastname: Castro
authors.forename: Alberto Miyar
authors.initials: AM
authors.lastname: de León
authors.forename: Jose Granero
authors.initials: JG
authors.lastname: Trancón
authors.forename: Paloma Alvarez
authors.initials: PA
authors.lastname: Martínez
authors.forename: Jose A
authors.initials: JA
authors.lastname: Alvarez Pérez
authors.forename: Jose C
authors.initials: JC
authors.lastname: Fernández Fernández
authors.forename: Carmen M
authors.initials: CM
authors.lastname: García Bernardo
authors.forename: Luis Barneo
authors.initials: LB
authors.lastname: Serra
authors.forename: Juan J
authors.initials: JJ
authors.lastname: González González