title: [Nosocomial transmission of hepatitis C associated with anesthesia procedures: a case-control study].
abstract: OBJECTIVE
  Nosocomial transmission of hepatitis C virus (HCV) infection had been related with anesthesia procedures. The study aim was to measure the association between anesthesia procedures in cases with previous surgery and HCV infection.
  
  
  METHODS
  In a case-control study were included subjects that attended to the Central Blood Bank of the West Medical National Center, Mexican Institute of the Social Security in Guadalajara, Jalisco between july 2005 and september 2007. Cases were patients with positive hepatitis C antibody (anti-HCV) confirmed by recombinant immunoblot assay (RIBA) and/or nucleic acid test (HCV RNA); the control group was blood donors with negative antibody. An exhaustive questionnaire about risk factors for hepatitis C, was applied. The risk of HCV infection was determined with the Odds Ratio (OR) and multivariate analysis was made by logistic regression.
  
  
  RESULTS
  We included 362 subjects, 211 cases and 151 controls; in 70 (33.2%) cases were found significant association between the anesthesia procedures and HCV infection in patients with previous surgery (OR adjusted 2.44, CI 95% 1.44 - 4.11)
  
  
  CONCLUSIONS
  This is the first study in México that demonstrate association between history of anesthesia procedures and HCV infection in cases with previous surgery.
authors.affiliation: Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, México. acontreras53@hotmail.com
authors.forename: Ana M
authors.initials: AM
authors.lastname: Contreras
authors.forename: Marcela
authors.initials: M
authors.lastname: Sotelo
authors.forename: Alfredo
authors.initials: A
authors.lastname: Celis
authors.forename: Diana B
authors.initials: DB
authors.lastname: Villalobos
authors.forename: Oscar
authors.initials: O
authors.lastname: Ancona-Piste
authors.forename: Rodolfo J
authors.initials: RJ
authors.lastname: Ochoa-Jiménez
authors.forename: Karina
authors.initials: K
authors.lastname: López-Ramírez
mesh_terms: D000758:Anesthesia / Q000706:statistics & numerical data; D018686:Anesthetics, Intravenous; D000779:Anesthetics, Local; D001803:Blood Transfusion / Q000706:statistics & numerical data; D016022:Case-Control Studies; D003428:Cross Infection / Q000453:epidemiology / Q000635:transmission*; D004340:Drug Contamination; D004349:Drug Packaging; D004866:Equipment Contamination; D017743:Equipment Reuse; D006526:Hepatitis C / Q000453:epidemiology / Q000635:transmission*; D006801:Humans; D008800:Mexico / Q000453:epidemiology; D012307:Risk Factors; D012965:Sodium Chloride; D015819:Substance Abuse, Intravenous / Q000453:epidemiology; D011795:Surveys and Questionnaires; D013594:Syringes / Q000009:adverse effects / Q000821:virology*; D065227:Transfusion Reaction; D014766:Viremia / Q000453:epidemiology
chemical_list: D018686:Anesthetics, Intravenous; D000779:Anesthetics, Local; D012965:Sodium Chloride