title: The ratio of serum leptin to adiponectin provides adjunctive information to the risk of metabolic syndrome beyond the homeostasis model assessment insulin resistance: the Korean Genomic Rural Cohort Study.
abstract: BACKGROUND
  Leptin and adiponectin are adipokines, shown to have opposing functions for fat metabolism and development of metabolic syndrome. We determined if the ratio of serum leptin to adiponectin (L/A ratio) adjunctively contributes to the risk of metabolic syndrome beyond the homeostasis model assessment of insulin resistance (HOMA-IR).
  
  
  METHODS
  This study included 1532 men and 1856 women, aged 40-70 y assessed in the Korean Genomic Rural Cohort Study from 2005 to 2008. The serum concentrations of adiponectin and leptin were measured by radioimmunoassay. Area under the receiver operating characteristic curve (AUROC) analyses were used to describe the ability of L/A ratio and HOMA-IR to differentiate between subjects with and without metabolic syndrome.
  
  
  RESULTS
  There were no significant differences in the ability of L/A ratio and HOMA-IR to predict metabolic syndrome (AUROC of L/A ratio vs. HOMA-IR, 0.771 vs. 0.774, p=0.8006 for men; 0.677 vs. 0.691, p=0.3088 for women). There was a significant adjunctive contribution by the L/A ratio, beyond that of HOMA-IR, to the risk of metabolic syndrome in men (p<0.0001 with 0.028 increased AUROC) and women (p=0.025 with 0.017 increased AUROC).
  
  
  CONCLUSIONS
  The L/A ratio provides significant adjunctive information to the risk of metabolic syndrome beyond HOMA-IR alone. The L/A ratio could be a good surrogate marker to assess metabolic syndrome.
authors.affiliation: Institute of Occupational and Environmental Medicine, Wonju College of Medicine, Yonsei University, Wonju 220-710, South Korea.
authors.forename: Jin-Ha
authors.initials: JH
authors.lastname: Yoon
authors.forename: Jong Ku
authors.initials: JK
authors.lastname: Park
authors.forename: Sung Soo
authors.initials: SS
authors.lastname: Oh
authors.forename: Ki-Hyun
authors.initials: KH
authors.lastname: Lee
authors.forename: Sung-Kyung
authors.initials: SK
authors.lastname: Kim
authors.forename: In-Jung
authors.initials: IJ
authors.lastname: Cho
authors.forename: Jong-Koo
authors.initials: JK
authors.lastname: Kim
authors.forename: Hee-Taik
authors.initials: HT
authors.lastname: Kang
authors.forename: Sung Gyun
authors.initials: SG
authors.lastname: Ahn
authors.forename: Jun-Won
authors.initials: JW
authors.lastname: Lee
authors.forename: Seung-Hwan
authors.initials: SH
authors.lastname: Lee
authors.forename: Aeyong
authors.initials: A
authors.lastname: Eom
authors.forename: Jang-Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Song Vogue
authors.initials: SV
authors.lastname: Ahn
authors.forename: Sang Baek
authors.initials: SB
authors.lastname: Koh
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D005260:Female; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D056910:Republic of Korea
chemical_list: D052242:Adiponectin; D020738:Leptin