title: Insertion of arynes into thioureas: a new amidine synthesis.
abstract: Arynes, generated from trimethylsilyl phenyltriflate precursors, have been found to react with thioureas via a formal π-insertion into the C═S bond. The reaction contrasts with that of ureas, which proceeds via benzyne σ-insertion into the C-N bond, and represents a new, operationally simple route to functionalized amidines.
authors.affiliation: School of Chemistry, University of Edinburgh, Joseph Black Building, King's Buildings, West Mains Rd., Edinburgh EH9 3JJ, UK.
authors.forename: Kallolmay
authors.initials: K
authors.lastname: Biswas
authors.forename: Michael F
authors.initials: MF
authors.lastname: Greaney
mesh_terms: D000578:Amidines / Q000138:chemical synthesis* / Q000737:chemistry; D001555:Benzene Derivatives / Q000737:chemistry*; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry*
chemical_list: D000578:Amidines; D001555:Benzene Derivatives; C524146:benzyne; D013890:Thiourea