title: Visualizing gene-set enrichment results using the Cytoscape plug-in enrichment map.
abstract: Gene-set enrichment analysis finds functionally coherent gene-sets, such as pathways, that are statistically overrepresented in a given gene list. Ideally, the number of resulting sets is smaller than the number of genes in the list, thus simplifying interpretation. However, the increasing number and redundancy of -gene-sets used by many current enrichment analysis resources work against this ideal. "Enrichment Map" is a Cytoscape plug-in that helps overcome gene-set redundancy and aids in the interpretation of enrichment results. Gene-sets are organized in a network, where each set is a node and links represent gene overlap between sets. Automated network layout groups related gene-sets into -network clusters, enabling the user to quickly identify the major enriched functional themes and more easily interpret enrichment results.
authors.affiliation: Banting and Best Department of Medical Research, Centre for Cellular and Biomolecular Research (CCBR), Toronto, ON, Canada.
authors.forename: Daniele
authors.initials: D
authors.lastname: Merico
authors.forename: Ruth
authors.initials: R
authors.lastname: Isserlin
authors.forename: Gary D
authors.initials: GD
authors.lastname: Bader
mesh_terms: D019295:Computational Biology / Q000379:methods*; D030541:Databases, Genetic; D053263:Gene Regulatory Networks; D012984:Software