title: Xanthoxyletin, a coumarin induces S phase arrest and apoptosis in human gastric adenocarcinoma SGC-7901 cells.
abstract: This study was conducted to explore the novel anticancer compounds from Chinese herbs. During the process of screening, to evaluate the potential chemopreventive effect of natural compounds, Xanthoxyletin was isolated from Erythrina variegata. It has been reported that Xanthoxyletin possesses antibacterial, fungicidal, and algicidal properties. In this study, we examined the antiproliferative effects of Xanthoxyletin against SGC-7901 cells and its ability to induce apoptosis and cell cycle arrest for the first time. We observed that its inhibitory effects on cells were associated with the DNA damage, apoptosis through mitochondrial dysfunction, and cell cycle arrest at S phase in a dose-dependent manner. Additionally, Xanthoxyletin also increased the production of reactive oxygen species in SGC-7901 cells. These results suggest that Xanthoxyletin may be promising anticancer agent and has worth for further mechanistic and therapeutic studies against gastric cancer.
authors.affiliation: Membrane Channel Research Laboratory, Institute of Genetics and Cytology, Northeast Normal University Jilin Province, China.
authors.forename: Azhar
authors.initials: A
authors.lastname: Rasul
authors.forename: Muhammad
authors.initials: M
authors.lastname: Khan
authors.forename: Bo
authors.initials: B
authors.lastname: Yu
authors.forename: Tonghui
authors.initials: T
authors.lastname: Ma
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003374:Coumarins / Q000494:pharmacology*; D004249:DNA Damage / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D004895:Erythrina; D006801:Humans; D008928:Mitochondria / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism; D059807:S Phase Cell Cycle Checkpoints / Q000187:drug effects*; D013274:Stomach Neoplasms / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents; D003374:Coumarins; D004365:Drugs, Chinese Herbal; D017382:Reactive Oxygen Species; C477468:xanthoxyletin