title: Molecular mechanisms of liver metastasis.
abstract: Colorectal cancer is the second most common cancer, and is the third leading cause of cancer-related death in Japan. The majority of these deaths is attributable to liver metastasis. Recent studies have provided increasing evidence that the chemokine-chemokine receptor system is a potential mechanism of tumor metastasis via multiple complementary actions: (a) by promoting cancer cell migration, invasion, survival and angiogenesis; and (b) by recruiting distal stromal cells (i.e., myeloid bone marrow-derived cells) to indirectly facilitate tumor invasion and metastasis. Here, we discuss recent preclinical and clinical data supporting the view that chemokine pathways are potential therapeutic targets for liver metastasis of colorectal cancer.
authors.affiliation: Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawara-cho, Sakyo-ku, Kyoto, 606-8507, Japan. kkawada@kuhp.kyoto-u.ac.jp
authors.forename: Kenji
authors.initials: K
authors.lastname: Kawada
authors.forename: Suguru
authors.initials: S
authors.lastname: Hasegawa
authors.forename: Teppei
authors.initials: T
authors.lastname: Murakami
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Itatani
authors.forename: Hisahiro
authors.initials: H
authors.lastname: Hosogi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sonoshita
authors.forename: Takanori
authors.initials: T
authors.lastname: Kitamura
authors.forename: Teruaki
authors.initials: T
authors.lastname: Fujishita
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Iwamoto
authors.forename: Takuya
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Ryo
authors.initials: R
authors.lastname: Matsusue
authors.forename: Koya
authors.initials: K
authors.lastname: Hida
authors.forename: Gaku
authors.initials: G
authors.lastname: Akiyama
authors.forename: Kae
authors.initials: K
authors.lastname: Okoshi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yamada
authors.forename: Junichiro
authors.initials: J
authors.lastname: Kawamura
authors.forename: Makoto Mark
authors.initials: MM
authors.lastname: Taketo
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Sakai
mesh_terms: D002465:Cell Movement / Q000235:genetics; D018925:Chemokines / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000473:pathology*; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000556:secondary*; D058990:Molecular Targeted Therapy; D022423:Myeloid Cells / Q000378:metabolism / Q000473:pathology; D009361:Neoplasm Invasiveness; D009389:Neovascularization, Pathologic / Q000378:metabolism; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D059016:Tumor Microenvironment
chemical_list: D018925:Chemokines; D019707:Receptors, Chemokine