title: Synthesis of various 5-alkoxymethyluracil analogues and structure-cytotoxic activity relationship study.
abstract: A number of 5-alkoxymethyluracil analogues were synthesized to evaluate their cytotoxic activity. 5-Alkoxymethyluracil derivatives 1 were prepared via known nucleophilic substitution of 5-chloromethyluracil 5 and subsequently transformed to their corresponding nucleosides 2. All prepared compounds were submitted to cytotoxic activity testing against drug sensitive and drug resistant leukaemia cells and solid tumour derived cell lines. In addition, the cytotoxic activity of 5-alkoxymethyluracil analogues 1 and 2 was compared with the previously published 5-[alkoxy(4-nitrophenyl)methyl]uracil analogues 3 and 4. Extensive structure-cytotoxic activity relationship studies are reported.
authors.affiliation: Department of Organic Chemistry, Faculty of Science, Palacký University, 17 Listopadu 12, Olomouc 771 46, Czech Republic.
authors.forename: Lucie
authors.initials: L
authors.lastname: Brulíková
authors.forename: Petr
authors.initials: P
authors.lastname: Džubák
authors.forename: Marián
authors.initials: M
authors.lastname: Hajdúch
authors.forename: Jan
authors.initials: J
authors.lastname: Hlaváč
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D013329:Structure-Activity Relationship; D014498:Uracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D014498:Uracil; C008378:6-methyluracil