title: High shear stress at the surface of enhancing plaque in the systolic phase is related to the symptom presentation of severe M1 stenosis.
abstract: The computational fluid dynamics methods for the limited flow rate and the small dimensions of an intracranial artery stenosis may help demonstrate the stroke mechanism in intracranial atherosclerosis. We have modeled the high wall shear stress (WSS) in a severe M1 stenosis. The high WSS in the systolic phase of the cardiac cycle was well-correlated with a thick fibrous cap atheroma with enhancement, as was determined using high-resolution plaque imaging techniques in a severe stenosis of the middle cerebral artery.
authors.affiliation: Department of Radiology and the Research Institute of Radiology, University of Ulsan, College of Medicine, Asan Medical Center, 86 Asanbyeongwon-gil, Songpa-gu, Seoul, Korea. dcsuh@amc.seoul.kr
authors.forename: Dae Chul
authors.initials: DC
authors.lastname: Suh
authors.forename: Sung-Tae
authors.initials: ST
authors.lastname: Park
authors.forename: Tack Sun
authors.initials: TS
authors.lastname: Oh
authors.forename: Sang-Ok
authors.initials: SO
authors.lastname: Park
authors.forename: Ok Kyun
authors.initials: OK
authors.lastname: Lim
authors.forename: Soonchan
authors.initials: S
authors.lastname: Park
authors.forename: Chang Woo
authors.initials: CW
authors.lastname: Ryu
authors.forename: Deok Hee
authors.initials: DH
authors.lastname: Lee
authors.forename: Young Bae
authors.initials: YB
authors.lastname: Ko
authors.forename: Sang-Wook
authors.initials: SW
authors.lastname: Lee
authors.forename: Kyunghwan
authors.initials: K
authors.lastname: Yoon
authors.forename: Jong Sung
authors.initials: JS
authors.lastname: Kim
mesh_terms: D001783:Blood Flow Velocity; D002533:Cerebral Angiography; D002560:Cerebrovascular Circulation; D019295:Computational Biology; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D021621:Imaging, Three-Dimensional; D002537:Intracranial Arteriosclerosis / Q000175:diagnosis*; D018810:Magnetic Resonance Angiography; D033081:Shear Strength; D012984:Software; D013599:Systole