title: Inhibition of intercellular adhesion in herpex simplex virus infection by glycyrrhizin.
abstract: Herpes simplex virus (HSV) is one of the most common viruses infecting humans and animals. Cellular adhesion is increased in HSV and plays a role in pathogenesis of inflammatory response during this viral infection. In our study, we studied a potential role of glycyrrhizin in disrupting cellular adhesion in HSV. We isolated rat cerebral capillary vessel endothelial cells (CCECs) and polymorphonuclear leukocytes (PMN) and evaluated intercellular adhesion between these cells by micropipette aspiration technique. The adhesion force and stress between CCEC and PMN were significantly (P < 0.01) increased in HSV infection. Glycyrrhizin perfusion significantly (P < 0.01) reduced adhesion force and stress between CCEC and PMN. In conclusion, glycyrrhizin may attenuate inflammatory responses in HSV by inhibition of adhesion between CCEC and PMN.
authors.affiliation: Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, People's Republic of China.
authors.forename: Wen
authors.initials: W
authors.lastname: Huang
authors.forename: Xiao
authors.initials: X
authors.lastname: Chen
authors.forename: Qi
authors.initials: Q
authors.lastname: Li
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.forename: Gaonian
authors.initials: G
authors.lastname: Zhao
authors.forename: Mingming
authors.initials: M
authors.lastname: Xu
authors.forename: Peng
authors.initials: P
authors.lastname: Xie
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D004730:Endothelium, Vascular / Q000473:pathology; D019695:Glycyrrhizic Acid / Q000494:pharmacology*; D006561:Herpes Simplex / Q000473:pathology*; D008297:Male; D009504:Neutrophils / Q000166:cytology / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D018139:Simplexvirus / Q000502:physiology
chemical_list: D000893:Anti-Inflammatory Agents; D019695:Glycyrrhizic Acid