title: Are immunoglobulin A anti-gliadin antibodies helpful in diagnosing coeliac disease in children younger than 2 years?
abstract: The usefulness of immumoglobulin (Ig) A antibodies to gliadin (AGA-IgA) in addition to IgA anti-endomysium and tissue transglutaminase antibodies was evaluated in 4122 children younger than 2 years with a suspicion of coeliac disease (CD). Eight percent (312/4122) displayed IgA anti-endomysium and/or IgA anti-tissue transglutaminase, whereas 2.1% (85/4122) displayed only AGA-IgA. Clinical data were obtained for 62 of 85 children with isolated AGA-IgA, and 33 children underwent a duodenal biopsy. Histologically proven CD was established for 5 patients, whereas 57 children were diagnosed to experience other diseases. The systematic detection of AGA-IgA using native gliadin conferred no additional diagnostic benefit for the diagnosis of CD in children younger than 2 years of age, except for rare cases.
authors.affiliation: Department of Immunology, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Inserm U851, Pierre-Benite, France.
authors.forename: Barbara
authors.initials: B
authors.lastname: Foucher
authors.forename: Catherine
authors.initials: C
authors.lastname: Johanet
authors.forename: Sophie
authors.initials: S
authors.lastname: Jégo-Desplat
authors.forename: Marielle
authors.initials: M
authors.lastname: Sanmarco
authors.forename: Sylvain
authors.initials: S
authors.lastname: Dubucquoi
authors.forename: Sandrine
authors.initials: S
authors.lastname: Fily-Nalewajk
authors.forename: Nils-Olivier
authors.initials: NO
authors.lastname: Olsson
authors.forename: Daniela
authors.initials: D
authors.lastname: Lakomy
authors.forename: Andrée
authors.initials: A
authors.lastname: Escande
authors.forename: Pascale
authors.initials: P
authors.lastname: Chrétien
authors.forename: Françoise
authors.initials: F
authors.lastname: Fortenfant
authors.forename: Alain
authors.initials: A
authors.lastname: Chevailler
authors.forename: Chantal
authors.initials: C
authors.lastname: André
authors.forename: Joëlle
authors.initials: J
authors.lastname: Goetz
authors.forename: René-Louis
authors.initials: RL
authors.lastname: Humbel
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Monier
authors.forename: Jean
authors.initials: J
authors.lastname: Sibilia
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Taillefer
authors.forename: Isabelle
authors.initials: I
authors.lastname: Abreu
authors.forename: Nicole
authors.initials: N
authors.lastname: Fabien
mesh_terms: D000888:Antibodies, Anti-Idiotypic / Q000097:blood*; D001706:Biopsy; D002446:Celiac Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D002675:Child, Preschool; D004386:Duodenum / Q000473:pathology; D005260:Female; D005903:Gliadin / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D015994:Incidence; D007223:Infant; D008297:Male; D011503:Transglutaminases / Q000276:immunology*
chemical_list: D000888:Antibodies, Anti-Idiotypic; D007070:Immunoglobulin A; C049937:anti-IgA; D005903:Gliadin; D011503:Transglutaminases