title: Cancer in pregnancy. Part I: basic diagnostic and therapeutic principles and treatment of gynecological malignancies.
abstract: OBJECTIVE
  Cancer in pregnancy is a rare circumstance. However, the coincidence of pregnancy and malignancy is supposed to increase due to a general tendency of postponing childbearing to older age. To date, clinical guidelines are scarce and experience regarding therapeutic management is limited to case reports.
  
  
  METHODS
  This review focuses on general diagnostic and therapeutic principles including systemic therapy for malignancies in pregnancy.
  
  
  RESULTS
  In part I, we report on diagnosis and therapy of gynecological tumors.
  
  
  CONCLUSIONS
  The diagnosis of gestational cancer faces both oncologist and obstetrician to the dilemma of applying appropriate diagnostic techniques and adequate local and systemic therapy to an expectant mother without harming the fetus.
authors.affiliation: Department of Obstetrics and Gynecology, University Hospital of Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany. Friederike.Hoellen@uksh.de
authors.forename: Friederike
authors.initials: F
authors.lastname: Hoellen
authors.forename: Roland
authors.initials: R
authors.lastname: Reibke
authors.forename: Katrin
authors.initials: K
authors.lastname: Hornemann
authors.forename: Marc
authors.initials: M
authors.lastname: Thill
authors.forename: Doerte W
authors.initials: DW
authors.lastname: Luedders
authors.forename: Katharina
authors.initials: K
authors.lastname: Kelling
authors.forename: Amadeus
authors.initials: A
authors.lastname: Hornemann
authors.forename: Michael K
authors.initials: MK
authors.lastname: Bohlmann
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D005833:Genital Neoplasms, Female / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis* / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents