title: [Fetal and neonatal alloimmune thrombocytopenia].
abstract: Fetal and neonatal alloimmune thrombocytopenia (FNAIT) may lead to intracranial haemorrhage (ICH) resulting in neurological damage or death. In FNAIT, transplacental maternal antibodies cause destruction of fetal platelets. Maternal immunisation occurs to fetal human platelet antigens (HPAs) inherited from the father. In the absence of screening the diagnosis often relies on a serious incident in a previous pregnancy or in a newborn sibling. Thus, a future reduction in the risk of ICH depends on prospective large trials to evaluate different diagnostic, treatment, and prevention strategies.
authors.affiliation: Klinisk Immunologisk Afdeling, Vævstypelaboratoriet, Rigshospitalet, Tagensvej 20, 2200 København N, Denmark. ellen.morling.taaning@rh.regionh.dk
authors.forename: Ellen Birkerod Morling
authors.initials: EB
authors.lastname: Taaning
authors.forename: Jens
authors.initials: J
authors.lastname: Kjeldsen-Kragh
authors.forename: Morten
authors.initials: M
authors.lastname: Hedegaard
authors.forename: Hanne Kristine
authors.initials: HK
authors.lastname: Hegaard
authors.forename: Tine Brink
authors.initials: TB
authors.lastname: Henriksen
authors.forename: Anne-Mette
authors.initials: AM
authors.lastname: Hvas
authors.forename: Hanne
authors.initials: H
authors.lastname: Kjærgaard
authors.forename: Ole Bredahl
authors.initials: OB
authors.lastname: Rasmussen
mesh_terms: D005260:Female; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D020300:Intracranial Hemorrhages / Q000209:etiology / Q000517:prevention & control; D015997:Neonatal Screening; D011247:Pregnancy; D011295:Prenatal Care; D011296:Prenatal Diagnosis; D011379:Prognosis; D054098:Thrombocytopenia, Neonatal Alloimmune / Q000175:diagnosis / Q000196:embryology / Q000401:mortality / Q000628:therapy