title: Transmission of dapsone-resistant leprosy detected by molecular epidemiological approaches.
abstract: Drug resistance surveillance identified six untreated leprosy patients in the Philippines with Mycobacterium leprae folP1 mutations which confer dapsone resistance. Five patients share a village of residence; four who carried the mutation, Thr53Val, were also linked by M. leprae variable-number tandem repeat (VNTR) strain types. In India, folP1 mutations were detected in two relapse patients with a history of dapsone treatment. Mutations were not found in the rifampin target gene rpoB. These findings indicate that dapsone resistance is being transmitted.
authors.affiliation: Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Rama M
authors.initials: RM
authors.lastname: Sakamuri
authors.forename: Danielle E
authors.initials: DE
authors.lastname: Lyons
authors.forename: Florenda M
authors.initials: FM
authors.lastname: Orcullo
authors.forename: Vidyagouri
authors.initials: V
authors.lastname: Shinde
authors.forename: Edred Lao
authors.initials: EL
authors.lastname: Dela Pena
authors.forename: Armi A
authors.initials: AA
authors.lastname: Maghanoy
authors.forename: Irene B
authors.initials: IB
authors.lastname: Mallari
authors.forename: Esterlina V
authors.initials: EV
authors.lastname: Tan
authors.forename: Indira
authors.initials: I
authors.lastname: Nath
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Brennan
authors.forename: Marivic
authors.initials: M
authors.lastname: Balagon
authors.forename: Varalakshmi
authors.initials: V
authors.lastname: Vissa
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics; D003622:Dapsone / Q000627:therapeutic use*; D006801:Humans; D007194:India; D007917:Leprostatic Agents / Q000627:therapeutic use*; D007918:Leprosy / Q000188:drug therapy* / Q000235:genetics / Q000635:transmission*; D017720:Molecular Epidemiology / Q000379:methods*; D009154:Mutation; D009166:Mycobacterium leprae / Q000187:drug effects* / Q000235:genetics / Q000472:pathogenicity*; D010679:Philippines; D012293:Rifampin / Q000627:therapeutic use
chemical_list: D001426:Bacterial Proteins; D007917:Leprostatic Agents; D003622:Dapsone; D012293:Rifampin