title: Comparison of in vitro breast cancer visibility in analyser-based computed tomography with histopathology, mammography, computed tomography and magnetic resonance imaging.
abstract: High-resolution analyser-based X-ray imaging computed tomography (HR ABI-CT) findings on in vitro human breast cancer are compared with histopathology, mammography, computed tomography (CT) and magnetic resonance imaging. The HR ABI-CT images provided significantly better low-contrast visibility compared with the standard radiological images. Fine cancer structures indistinguishable and superimposed in mammograms were seen, and could be matched with the histopathological results. The mean glandular dose was less than 1 mGy in mammography and 12-13 mGy in CT and ABI-CT. The excellent visibility of in vitro breast cancer suggests that HR ABI-CT may have a valuable role in the future as an adjunct or even alternative to current breast diagnostics, when radiation dose is further decreased, and compact synchrotron radiation sources become available.
authors.affiliation: Department of Physics, HUCH Cancer Center, Helsinki University Central Hospital, Helsinki, Finland. jani.keyrilainen@hus.fi
authors.forename: Jani
authors.initials: J
authors.lastname: Keyriläinen
authors.forename: Manuel
authors.initials: M
authors.lastname: Fernández
authors.forename: Alberto
authors.initials: A
authors.lastname: Bravin
authors.forename: Marja Liisa
authors.initials: ML
authors.lastname: Karjalainen-Lindsberg
authors.forename: Marjut
authors.initials: M
authors.lastname: Leidenius
authors.forename: Karl
authors.initials: K
authors.lastname: von Smitten
authors.forename: Mikko
authors.initials: M
authors.lastname: Tenhunen
authors.forename: Aki
authors.initials: A
authors.lastname: Kangasmäki
authors.forename: Petri
authors.initials: P
authors.lastname: Sipilä
authors.forename: Christian
authors.initials: C
authors.lastname: Nemoz
authors.forename: Pekka
authors.initials: P
authors.lastname: Virkkunen
authors.forename: Pekka
authors.initials: P
authors.lastname: Suortti
mesh_terms: D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging / Q000473:pathology; D018275:Carcinoma, Lobular / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008327:Mammography / Q000379:methods*; D011829:Radiation Dosage; D017356:Synchrotrons; D014057:Tomography, X-Ray Computed / Q000379:methods*