title: Acute response of plasma markers of bone turnover to a single bout of resistance training or plyometrics.
abstract: The time course of changes in plasma bone turnover markers following an acute bout of resistance training (RT) or plyometrics (PLY) has not been well characterized. This study is the first to compare the acute response of bone formation and resorption markers to a single bout of RT or PLY. Using a partially randomized, cross-over study design, 12 recreationally active men, aged 43 ± 5 yr, each completed four exercise trials: RT (Fed/Fasted) and PLY (Fed/Fasted). In addition to the RT and PLY trials, 5 of the original 12 participants also completed a fasted, no-exercise control trial to examine time-of-day variation. For each trial, blood was drawn immediately before exercise (PRE), immediately following exercise, and 15 min, 30 min, 1 h, 2 h, and 24 h following PRE for determination of plasma bone-specific alkaline phosphatase (BAP), osteocalcin (OC), tartrate-resistant acid phosphatase 5b (TRAP5b), COOH-terminal telopeptide of type I collagen (CTX), testosterone, parathyroid hormone, and cortisol. A one-factor repeated-measures ANOVA was performed for each trial to detect changes in bone markers during the 2 h following RT or PLY. TRAP5b transiently decreased during the 2 h following all exercise trials (main effect for time, P < 0.05), but returned to PRE concentrations 2 h postexercise. BAP, CTX, and OC remained unchanged, except for reductions in BAP and CTX following PLY-Fasted and PLY-Fed, respectively. During the control trial, BAP decreased, while TRAP5b, CTX, and OC remained unchanged. In general, plasma hormone concentrations decreased during the 2 h following PLY or RT, and cumulative decreases in TRAP5b during the 2 h following exercise were positively correlated with cumulative decreases in parathyroid hormone. The results of the present study suggest that the timing of the measurement of bone turnover markers relative to the last exercise bout is important for detection of exercise-associated changes in bone turnover markers, as the markers returned to preexercise values within 2 h of RT or PLY.
authors.affiliation: Dept. of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri 65211, USA. hintonp@missouri.edu
authors.forename: Robert S
authors.initials: RS
authors.lastname: Rogers
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Dawson
authors.forename: Ze
authors.initials: Z
authors.lastname: Wang
authors.forename: John P
authors.initials: JP
authors.lastname: Thyfault
authors.forename: Pamela S
authors.initials: PS
authors.lastname: Hinton
mesh_terms: D000135:Acid Phosphatase / Q000097:blood; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016723:Bone Remodeling / Q000502:physiology*; D001862:Bone Resorption / Q000097:blood* / Q000503:physiopathology; D024042:Collagen Type I / Q000097:blood; D018592:Cross-Over Studies; D015444:Exercise / Q000502:physiology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007527:Isoenzymes / Q000097:blood; D008297:Male; D015675:Osteocalcin / Q000097:blood; D010012:Osteogenesis / Q000502:physiology*; D010281:Parathyroid Hormone / Q000097:blood; D059385:Plyometric Exercise / Q000379:methods; D055070:Resistance Training / Q000379:methods*; D000071681:Tartrate-Resistant Acid Phosphatase; D013739:Testosterone / Q000097:blood
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D007527:Isoenzymes; D010281:Parathyroid Hormone; D015675:Osteocalcin; D013739:Testosterone; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase; D006854:Hydrocortisone