title: Comparison of newly diagnosed ocular hypertension and open-angle glaucoma: ocular variables, risk factors, and disease severity.
abstract: Purpose. To describe the distribution of ocular variables, risk factors, and disease severity in newly diagnosed ocular hypertension (OH) or open-angle glaucoma (OAG). Methods. Eligible subjects underwent a complete history and examination. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) obtained from multiple logistic regression models were used to compare OAG to OH and advanced to early/moderate OAG. Results. 405 subjects were enrolled: 292 (72.1%) with OAG and 113 (27.9%) with OH. 51.7% had early, 27.1% moderate, and 20.9% advanced OAG. The OR for OAG versus OH was 8.19 (P < 0.0001) for disc notch, 5.36 (P < 0.0001) for abnormal visual field, 1.45 (P = 0.001) for worsening mean deviation, 1.91 (P < 0.0001) for increased cupping, 1.03 for increased age (P = 0.030), and 0.36 (P = 0.010) for smoking. Conclusions. Increased age was a risk for OAG, and smoking decreased the risk of OAG compared to OH. Almost half of the OAG subjects had moderate/advanced disease at diagnosis.
authors.affiliation: Department of Ophthalmology, University of Toronto, 399 Bathurst Street, EW 6-405, Toronto, ON, M5T 2S8, Canada.
authors.forename: Yvonne M
authors.initials: YM
authors.lastname: Buys
authors.forename: Paul
authors.initials: P
authors.lastname: Harasymowycz
authors.forename: Rania
authors.initials: R
authors.lastname: Gaspo
authors.forename: Kenneth
authors.initials: K
authors.lastname: Kwok
authors.forename: Cindy M L
authors.initials: CM
authors.lastname: Hutnik
authors.forename: Pierre
authors.initials: P
authors.lastname: Blondeau
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Birt
authors.forename: Robert L G
authors.initials: RL
authors.lastname: Piemontesi
authors.forename: Lisa F
authors.initials: LF
authors.lastname: Gould
authors.forename: Mark R
authors.initials: MR
authors.lastname: Lesk
authors.forename: Iqbal K
authors.initials: IK
authors.lastname: Ahmed