title: Interleukin-10 but not interleukin-18 may be associated with the immune response against well-differentiated thyroid cancer.
abstract: OBJECTIVE
  The aim of this study was to investigate the role of the interleukin-18 +105A/C and interleukin-10 -1082A/G germline polymorphisms in the development and outcome of differentiated thyroid carcinoma associated or not with concurrent thyroiditis.
  
  
  METHODS
  We studied 346 patients with differentiated thyroid carcinomas, comprising 292 papillary carcinomas and 54 follicular carcinomas, who were followed up for 12-298 months (mean 76.10 ± 68.23 months) according to a standard protocol. We genotyped 200 patients and 144 control individuals for the interleukin-18 +105A/C polymorphism, and we genotyped 183 patients and 137 controls for the interleukin-10 -1082A/G polymorphism.
  
  
  RESULTS
  Interleukin-18 polymorphisms were not associated with chronic lymphocytic thyroiditis or any clinical or pathological feature of tumor aggressiveness. However, there was an association between the presence of interleukin-10 variants and chronic lymphocytic thyroiditis. Chronic lymphocytic thyroiditis was present in 21.74% of differentiated thyroid carcinoma patients, most frequently affecting women previously diagnosed with Hashimoto's thyroiditis who had received a lower 131I cumulative dose and did not present lymph node metastases.
  
  
  CONCLUSIONS
  We conclude that the inheritance of a G allele at the interleukin-10 -1082A/G polymorphism may favor a concurrent thyroid autoimmunity in differentiated thyroid carcinoma patients, and this autoimmunity may favor a better prognosis for these patients.
authors.affiliation: Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences, University of Campinas, Campinas, SP, Brazil. lucasleitecunha@gmail.com
authors.forename: Lucas Leite
authors.initials: LL
authors.lastname: Cunha
authors.forename: Alfio Jose
authors.initials: AJ
authors.lastname: Tincani
authors.forename: Ligia Vera Montalli da
authors.initials: LV
authors.lastname: Assumpção
authors.forename: Fernando Augusto
authors.initials: FA
authors.lastname: Soares
authors.forename: José
authors.initials: J
authors.lastname: Vassallo
authors.forename: Laura Sterian
authors.initials: LS
authors.lastname: Ward
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002277:Carcinoma / Q000235:genetics* / Q000276:immunology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D050031:Hashimoto Disease / Q000235:genetics / Q000276:immunology; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics* / Q000276:immunology; D020382:Interleukin-18 / Q000235:genetics* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D018709:Statistics, Nonparametric; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000276:immunology; D055815:Young Adult
chemical_list: D020382:Interleukin-18; D016753:Interleukin-10