title: Iodine-catalyzed amination of benzoxazoles: a metal-free route to 2-aminobenzoxazoles under mild conditions.
abstract: A facile metal-free route of oxidative amination of benzoxazole by activation of C-H bonds with secondary or primary amines in the presence of catalytic iodine in aqueous tert-butyl hydroperoxide proceeds smoothly at ambient temperature under neat reaction condition to furnish the high yield of the aminated product. This user-friendly method to form C-N bonds produces tertiary butanol and water as the byproduct, which are environmentally benign. The application of the methodology is demonstrated by synthesizing therapeutically active benzoxazoles.
authors.affiliation: Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, Karnataka, India.
authors.forename: Manjunath
authors.initials: M
authors.lastname: Lamani
authors.forename: Kandikere Ramaiah
authors.initials: KR
authors.lastname: Prabhu
mesh_terms: D000085:Acetates / Q000737:chemistry; D000586:Amination; D001583:Benzoxazoles / Q000737:chemistry*; D002384:Catalysis; D055772:Green Chemistry Technology / Q000379:methods*; D007455:Iodine / Q000737:chemistry*
chemical_list: D000085:Acetates; D001583:Benzoxazoles; D007455:Iodine