title: Allergy and the bone: unexpected relationships.
abstract: OBJECTIVE
  To examine the relationships between allergy and bone metabolism as represented by the effects of antihistamines and leukotriene modifiers on bone resorption and formation.
  
  
  METHODS
  The major databases MEDLINE and Scopus were searched using the keywords bone metabolism, bone resorption, bone formation, antihistamines, h1 antagonist, leukotriene antagonist, and leukotriene modifier.
  
  
  METHODS
  The studies were independently evaluated by all the coauthors, who judged their pertinence to this review.
  
  
  RESULTS
  Two of the most intriguing aspects in the field are the possible effects of leukotriene modifiers on fracture repair and the hypothesized role of antihistamines in contrasting osteoporosis. Another rapidly expanding field of research is that related to the immune-modulating effects of vitamin D because serum levels of vitamin D have been shown to correlate with pulmonary function, asthma onset, and the development of allergic diseases.
  
  
  CONCLUSIONS
  Although unexpected, data are now available suggesting a strict connection among allergy, its treatments, and bone metabolism.
authors.affiliation: Rheumatologic Department, University of Verona, Verona, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Gatti
authors.forename: Gianenrico
authors.initials: G
authors.lastname: Senna
authors.forename: Ombretta
authors.initials: O
authors.lastname: Viapiana
authors.forename: Maurizio
authors.initials: M
authors.lastname: Rossini
authors.forename: Giovanni
authors.initials: G
authors.lastname: Passalacqua
authors.forename: Silvano
authors.initials: S
authors.lastname: Adami
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000188:drug therapy; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism*; D005260:Female; D050723:Fractures, Bone / Q000188:drug therapy; D006633:Histamine Antagonists / Q000627:therapeutic use*; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy*; D020024:Leukotriene Antagonists / Q000494:pharmacology; D015289:Leukotrienes / Q000494:pharmacology; D008297:Male; D051379:Mice; D010012:Osteogenesis / Q000187:drug effects; D010024:Osteoporosis / Q000188:drug therapy; D051381:Rats; D014807:Vitamin D / Q000276:immunology / Q000378:metabolism
chemical_list: D006633:Histamine Antagonists; D020024:Leukotriene Antagonists; D015289:Leukotrienes; D014807:Vitamin D