title: mRNA expression levels of the biological factors uPAR, uPAR-del4/5, and rab31, displaying prognostic value in breast cancer, are not clinically relevant in advanced ovarian cancer.
abstract: High tumor tissue mRNA expression of the tumor biological factors uPAR, uPAR-del4/5, or rab31 is associated with shorter distant metastasis-free and overall survival in breast cancer patients. To evaluate whether these factors are also clinically relevant in ovarian cancer, we quantified the respective mRNA levels in primary tumor tissue of advanced ovarian cancer patients (n=103) and evaluated their association with clinicopathological parameters and patients' prognosis. mRNA expression levels of all three markers did not show any significant association with overall or progression-free survival, demonstrating that these factors have no prognostic value in advanced ovarian cancer.
authors.affiliation: Institut für Pathologie, Technische Universität Dresden, D-01307 Dresden, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Kotzsch
authors.forename: Julia
authors.initials: J
authors.lastname: Dorn
authors.forename: Kristina
authors.initials: K
authors.lastname: Doetzer
authors.forename: Barbara
authors.initials: B
authors.lastname: Schmalfeldt
authors.forename: Janna
authors.initials: J
authors.lastname: Krol
authors.forename: Gustavo
authors.initials: G
authors.lastname: Baretton
authors.forename: Marion
authors.initials: M
authors.lastname: Kiechle
authors.forename: Manfred
authors.initials: M
authors.lastname: Schmitt
authors.forename: Viktor
authors.initials: V
authors.lastname: Magdolen
mesh_terms: D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009154:Mutation; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D010053:Ovary / Q000378:metabolism / Q000473:pathology; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics*; D055293:Receptors, Urokinase Plasminogen Activator / Q000235:genetics*; D020691:rab GTP-Binding Proteins / Q000235:genetics*
chemical_list: C484190:RAB31 protein, human; D012333:RNA, Messenger; D055293:Receptors, Urokinase Plasminogen Activator; D020691:rab GTP-Binding Proteins