title: [Effects of exercise and nilestriol on bone size and bone mass in ovariectomized rats].
abstract: OBJECTIVE
  To investigate the influence of nilestriol (CCE3) and exercise on bone size and bone mass in ovariectomized (OVX) rats.
  
  
  METHODS
  Forty eight (48) female Sprague-Dawley (SD) rats were divided randomly into six groups: (1) Normal control group, (2) Sham OVX group, (3) OVX group, (4) OVX + CCE3 group, (5)) OVX + exercise group, (6) OVX + CCE3 + exercise group. CCE (0.5 mg/kg per week) was given to the rats in OVX + CCE3 group and OVX + CCE3 + exercise group from the 2nd day after the operation for 11 weeks. Exercise training was loaded to the rats in exercise groups from the 7th day after operation, each rat was subjected to running on 0 dig angle runway with the speed of 16 m per minute, 45 minutes per day, 5 days per week for 10 weeks.
  
  
  RESULTS
  The bone diameter, bone volume, bone wet weight, bone dry weight, bone ashes weight in the OVX group were lower than those in the sham OVX group (P < 0.01). All of these measurements were increased in OVX + CCE3 group and OVX + exercise group when compared with the OVX group, but were still lower than those in sham OVX group (P < 0.01). Exercise enhances the effect of CCE3 (P < 0.01).
  
  
  CONCLUSIONS
  Exercise enhances the effects of CCE3 on the improvement of both bone size and quantity in OVX rats.
authors.affiliation: Department of Biochemistry, Basic Education School of Zhanjiang Normal University, Zhanjiang 524037, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Song
authors.forename: Zhao-Qiang
authors.initials: ZQ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D015519:Bone Density; D001842:Bone and Bones / Q000033:anatomy & histology*; D003131:Combined Modality Therapy; D004964:Estriol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005260:Female; D010024:Osteoporosis / Q000209:etiology / Q000628:therapy*; D010052:Ovariectomy; D005082:Physical Exertion; D011800:Quinestrol / Q000031:analogs & derivatives; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: C010722:nylestriol; D004964:Estriol; D011800:Quinestrol