title: Mitochondria-targeting single-walled carbon nanotubes for cancer photothermal therapy.
abstract: Nanomaterials have recently attracted much attention as efficient transducers for cancer photothermal therapy, based on their intrinsic absorption properties in the near-infrared region. This study explores a novel therapy model with mitochondria-targeting single-walled carbon nanotubes (SWNTs), which act efficiently to convert 980-nm laser energy into heat and selectively destroy the target mitochondria, thereby inducing mitochondrial depolarization, cytochrome c release, and caspase 3 activation. The laser+SWNTs process affords remarkable efficacy in suppressing tumor growth in a breast cancer model, and results in complete tumor regression in some cases. Laser+SWNTs could prove to be a promising selective local treatment modality, while minimizing adverse side effects.
authors.affiliation: MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.
authors.forename: Feifan
authors.initials: F
authors.lastname: Zhou
authors.forename: Shengnan
authors.initials: S
authors.lastname: Wu
authors.forename: Baoyan
authors.initials: B
authors.lastname: Wu
authors.forename: Wei R
authors.initials: WR
authors.lastname: Chen
authors.forename: Da
authors.initials: D
authors.lastname: Xing
mesh_terms: D000818:Animals; D016923:Cell Death; D045744:Cell Line, Tumor; D004847:Epithelial Cells / Q000378:metabolism; D005260:Female; D006979:Hyperthermia, Induced; D007834:Lasers; D051379:Mice; D008807:Mice, Inbred BALB C; D008928:Mitochondria / Q000378:metabolism*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D009369:Neoplasms / Q000378:metabolism / Q000628:therapy*; D010789:Phototherapy; D011092:Polyethylene Glycols / Q000737:chemistry
chemical_list: D037742:Nanotubes, Carbon; D011092:Polyethylene Glycols