title: Familial tumoral calcinosis in two Chinese patients: a case series.
abstract: BACKGROUND
  Tumoral calcinosis is a rare and benign condition characterized by massive subcutaneous soft tissue deposits of calcium phosphate predominantly around large joints.
  
  
  METHODS
  Familial tumoral calcinosis was present in two members of a Han Chinese family, namely, the son and daughter. The 14-year-old son had the first operation on his right sole of the foot at the age of six, and then experienced subsequent surgeries at a lesion in his right sole of the foot and left hip, respectively. The 16-year-old daughter underwent her first operation at the age of six in her left gluteal region, and subsequent surgeries were performed due to recurrence at the same lesion. Pathologic diagnoses of surgical specimens in both of the patients were reported as tumoral calcinosis. The laboratory results showed hyperphosphatemia with normal levels of serum calcium and alkaline phosphatase. Only surgical treatment was performed in both patients with satisfactory prognosis.
  
  
  CONCLUSIONS
  This is the first report of Chinese familial tumoral calcinosis. The etiopathogenisis and treatment are discussed.
authors.affiliation: Taihe Hospital affiliated to Hubei Medical University, No, 32 South People's Road, Shiyan, Hubei Province, 442000, P,R,China. xiongkui@csco.org.cn.
authors.forename: Che
authors.initials: C
authors.lastname: Zhang
authors.forename: Jiaowei
authors.initials: J
authors.lastname: Gu
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Cheng
authors.forename: Kui
authors.initials: K
authors.lastname: Xiong