title: Diffusion-tensor imaging assessment of white matter maturation in childhood and adolescence.
abstract: OBJECTIVE
  The purpose of this study was to test a first hypothesis that fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values continue to change in late childhood and adolescence and a second hypothesis that less mature white matter (WM) regions have a higher rate of change than WM regions that are relatively more mature.
  
  
  METHODS
  Eighty-seven healthy children (50 girls, 37 boys; mean age, 11.2 ± 3.6 years; range, 4.2-17.7 years) underwent six-direction diffusion-tensor imaging with a 3-T MRI system. Three neuroradiologists independently drew regions of interest in 10 WM regions and measured FA and ADC values. To test the first hypothesis, we correlated these values with subject age by linear regression analysis (p < 0.05). To test the second hypothesis, we determined whether regions with lower FA and higher ADC in the 4- to 7-year old group had a higher slope of FA increase and ADC decrease over the entire age range. For this assessment, we used linear regression analysis (p < 0.05) and curve fitting.
  
  
  RESULTS
  In the test of the first hypothesis, increases in FA with age were noted in all WM regions and were statistically significant in six regions. Decreases in ADC values with age were noted in all brain regions except the genu of the corpus callosum. In all other regions except the splenium of the corpus callosum, the decreases were statistically significant. In the test of the second hypothesis, the relation between FA in the 4- to 7-year-old subjects and the FA increase in the entire sample was best described with a linear equation. The rate of age-related FA increase tended to be greater with lower initial FA (r = -0.384, p = 0.271). The relation between ADC in the 4- to 7-year-old subjects and ADC decrease in the entire population was best described with a second-order equation. The rate of age-related ADC decrease tended to be greater with higher initial ADC (r = 0.846, p = 0.001). For ADC values of 100 or less at age 4-7 years, the rate of ADC change with age tended to be decrease as initial ADC increased.
  
  
  CONCLUSIONS
  In general, both hypotheses were verified. Overall, FA values continue to increase and ADC values continue to decrease during childhood and adolescence. The most rapid changes were found in WM regions that were least mature in the first few years of the study period.
authors.affiliation: Department of Radiology, Konkuk University School of Medicine, Konkuk University Medical Center, Seoul, South Korea.
authors.forename: Won-Jin
authors.initials: WJ
authors.lastname: Moon
authors.forename: James M
authors.initials: JM
authors.lastname: Provenzale
authors.forename: Basar
authors.initials: B
authors.lastname: Sarikaya
authors.forename: Yon Kwon
authors.initials: YK
authors.lastname: Ihn
authors.forename: John
authors.initials: J
authors.lastname: Morlese
authors.forename: Steven
authors.initials: S
authors.lastname: Chen
authors.forename: Michael D
authors.initials: MD
authors.lastname: DeBellis
mesh_terms: D000293:Adolescent; D000367:Age Factors; D016880:Anisotropy; D001921:Brain / Q000254:growth & development*; D001931:Brain Mapping / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000502:physiology*; D011446:Prospective Studies; D018709:Statistics, Nonparametric