title: Evaluation of antioxidant and neuroprotective effect of date palm (Phoenix dactylifera L.) against bilateral common carotid artery occlusion in rats.
abstract: The cerebral ischemia in rats was induced by occluding bilateral common carotid arteries (BCCAO) for 30 min., followed by 45 min reperfusion. BCCAO caused significant depletion in superoxide dismutase, catalase, glutathione, glutathione peroxidase, glutathione-S-transferase, glutathione reductase and significant increase in lipid peroxidation along with severe neuronal damage in the brain. All the alterations except depletion in glutathione peroxidase and glutathione-S-transferase levels induced by cerebral ischemia were significantly attenuated by 15 days pretreatment with methanolic extract of P. dactylifera fruits (100, 300 mg/kg), whereas 30 mg/kg dose was insignificant in this regard. These results suggest the possible use P. dactylifera against bilateral common carotid artery occlusion induced oxidative stress and neuronal damage.
authors.affiliation: Department of Pharmacology, AISSMS College of Pharmacy, Kennedy Road, Near RTO, Pune-411 001, India. rohinipujari@yahoo.com
authors.forename: Rohini R
authors.initials: RR
authors.lastname: Pujari
authors.forename: Neeraj S
authors.initials: NS
authors.lastname: Vyawahare
authors.forename: Virendra G
authors.initials: VG
authors.lastname: Kagathara
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000627:therapeutic use* / Q000633:toxicity; D028023:Arecaceae / Q000737:chemistry*; D002545:Brain Ischemia / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D017536:Carotid Artery, Common / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D016893:Carotid Stenosis / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005638:Fruit / Q000737:chemistry; D008297:Male; D051379:Mice; D018696:Neuroprotective Agents / Q000302:isolation & purification / Q000627:therapeutic use* / Q000633:toxicity; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D023382:Toxicity Tests, Acute
chemical_list: D000975:Antioxidants; D018696:Neuroprotective Agents; D010936:Plant Extracts