title: Diffuse myelitis after treatment of cerebral aspergillosis in an immune competent patient.
abstract: Presentation of an unusual case of cerebral aspergillosis in an immune competent patient who was treated successfully but symptoms and signs of a demyelinating process following initial recovery has been occurred. A 29-year-old male with focal seizure. Brain MRI revealed small multiple hemispheric and dural lesions. An open biopsy was conducted. Histological evaluation revealed hyphe-like structure in the necrotic area, within vessel walls, and lumina, suggestive aspergillus fumigatus . Furthermore, brancheal hyphae in potassium hydrxide 15% and colonies on sabourud dextrose agar were observed. Based of the above findings the patient underwent anti fungal therapy. The patient recovered and continued a normal life however a follow up MRI was performed after 3 months from recovery. No significant abnormality was observed from the MRI procedure. One month later the patient developed signs and symptoms of spinal cord involvement which seemed to be the result of myelitis. A brain MR showed no abnormalities .Therefore it seemed reasonable to administer corticosteroid as a treatment for suspected active demyelinating process. During the above treatment, signs and symptoms of myelopathy disappeared and a whole spine MRI showed remarkable improvement.
authors.affiliation: Department of Neurosurgery, Firoozgar Hospital, Tehran University of Medical Science, Tehran, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Mollahoseini
authors.forename: Mahdi
authors.initials: M
authors.lastname: Nikoobakht
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D001232:Aspergillus fumigatus / Q000302:isolation & purification*; D001706:Biopsy; D001927:Brain Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009187:Myelitis / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D020953:Neuroaspergillosis / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D012640:Seizures / Q000382:microbiology; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000935:Antifungal Agents