title: [Hyperbaric oxygenation in the treatment of patients with interstitial cystitis: clinical and morphological rationale].
abstract: We studied efficacy of hyperbaric oxygenation (HBO) in 8 patients with interstitial cystitis/painful bladder syndrome (IC/PBS). Mean age of the patients was 53 years (35-72 years), mean duration of the disease 7.5 years (6-17 years). Ulcerative IC/PBS was diagnosed in 7 of 8 patients. The patients received combined treatment: surgical (hydrobouginage of the bladder, electrocoagulation of bladder ulcer) and a HBO course in the postoperative period. The efficacy was assessed by clinical and morphological criteria (estimation of histamine level in urethral smears, proliferative activity of bladder mucosa epithelial cells). A HBO course consisted of 10 sessions (40 min, 2 atm). The treatment reduced the number of voidings for 24 hours, increased mean effective bladder volume, lowered a total score by L. Parsons scale, histamine content in urethral smears, stimulated proliferative activity of bladder mucosa epithelium. Thus, HBO proved its safety and effectiveness in combined treatment of IC/PBS.
authors.forename: O B
authors.initials: OB
authors.lastname: Loran
authors.forename: L A
authors.initials: LA
authors.lastname: Siniakova
authors.forename: A V
authors.initials: AV
authors.lastname: Seregin
authors.forename: A A
authors.initials: AA
authors.lastname: Mitrokhin
authors.forename: A M
authors.initials: AM
authors.lastname: Plesovskiĭ
authors.forename: N A
authors.initials: NA
authors.lastname: Vinarova
mesh_terms: D000328:Adult; D000368:Aged; D018856:Cystitis, Interstitial / Q000473:pathology* / Q000628:therapy*; D005260:Female; D006801:Humans; D006931:Hyperbaric Oxygenation; D008875:Middle Aged; D012074:Remission Induction; D013997:Time Factors; D001743:Urinary Bladder / Q000473:pathology*