title: Lipid arrays identify myelin-derived lipids and lipid complexes as prominent targets for oligoclonal band antibodies in multiple sclerosis.
abstract: The presence of oligoclonal bands of IgG (OCB) in cerebrospinal fluid (CSF) is used to establish a diagnosis of multiple sclerosis (MS), but their specificity has remained an enigma since its first description over forty years ago. We now report that the use of lipid arrays identifies heteromeric complexes of myelin derived lipids as a prominent target for this intrathecal B cell response.
authors.affiliation: Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, G12 8TA, UK.
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: Brennan
authors.forename: Francesc
authors.initials: F
authors.lastname: Galban-Horcajo
authors.forename: Simon
authors.initials: S
authors.lastname: Rinaldi
authors.forename: Colin P
authors.initials: CP
authors.lastname: O'Leary
authors.forename: Carl S
authors.initials: CS
authors.lastname: Goodyear
authors.forename: Gabriela
authors.initials: G
authors.lastname: Kalna
authors.forename: Ariel
authors.initials: A
authors.lastname: Arthur
authors.forename: Christina
authors.initials: C
authors.lastname: Elliot
authors.forename: Sue
authors.initials: S
authors.lastname: Barnett
authors.forename: Christopher
authors.initials: C
authors.lastname: Linington
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Bennett
authors.forename: Gregory P
authors.initials: GP
authors.lastname: Owens
authors.forename: Hugh J
authors.initials: HJ
authors.lastname: Willison
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism; D002478:Cells, Cultured; D004622:Embryo, Mammalian; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid*; D050356:Lipid Metabolism; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000276:immunology / Q000473:pathology; D004676:Myelin Basic Protein / Q000378:metabolism; D009186:Myelin Sheath / Q000276:immunology / Q000378:metabolism*; D019081:O Antigens / Q000378:metabolism; D043025:Oligoclonal Bands / Q000276:immunology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000166:cytology
chemical_list: D007074:Immunoglobulin G; D004676:Myelin Basic Protein; D019081:O Antigens; D043025:Oligoclonal Bands