title: Basaloid squamous cell carcinoma of the larynx--A systematic review.
abstract: OBJECTIVE
  This study pools all the cases of Basaloid squamous cell carcinoma of the larynx in the English literature to investigate the clinical course of this rare clinico-pathological disease entity.
  
  
  METHODS
  We found and analyzed 100 cases with individual patient data from 36 publications spanning 20 years.
  
  
  RESULTS
  It is a rare disease of the elderly with strong male predominance and more common in the supraglottis. Patients typically present with locoregionally advanced stage. Surgery alone or combined with radiotherapy is commonly reported. It has a worse survival outcome when compared to laryngeal cancers in general. Twenty-two percent eventually develop distant metastases with the lung being the predominant site.
  
  
  CONCLUSIONS
  Given the rarity of this clinical condition and the lack of data from studies with adequate number of cases, this systematic literature analysis provides the best possible relevant evidence.
authors.affiliation: Head and Neck Institute, Amrita Institute of Medical Sciences, Kochi, 682041, India. drkrishnakumart@yahoo.co.in
authors.forename: Krishnakumar
authors.initials: K
authors.lastname: Thankappan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality* / Q000628:therapy*; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D011878:Radiotherapy
chemical_list: D000970:Antineoplastic Agents