title: Noise amplification in human tumor suppression following gamma irradiation.
abstract: The influence of noise on oscillatory motion is a subject of permanent interest, both for fundamental and practical reasons. Cells respond properly to external stimuli by using noisy systems. We have clarified the effect of intrinsic noise on the dynamics in the human cancer cells following gamma irradiation. It is shown that the large amplification and increasing mutual information with delay are due to coherence resonance. Furthermore, frequency domain analysis is used to study the mechanisms.
authors.affiliation: Key Laboratory of Beam Technology and Material Modification of Ministry of Education, College of Nuclear Science and Technology, Beijing Normal University, Beijing, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.forename: Shiwei
authors.initials: S
authors.lastname: Yan
authors.forename: Xingfa
authors.initials: X
authors.lastname: Gao
mesh_terms: D045744:Cell Line, Tumor; D005583:Fourier Analysis; D005720:Gamma Rays; D006801:Humans; D008962:Models, Theoretical; D009622:Noise; D051736:Proto-Oncogene Proteins c-mdm2 / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D016159:Tumor Suppressor Protein p53; D051736:Proto-Oncogene Proteins c-mdm2