title: Effects of Roux-en-Y operations on glucose homeostasis in obese GK rats.
abstract: OBJECTIVE
  To investigate the therapeutic effects of different styles of gastric bypass surgery on type 2 diabetes mellitus (T2DM) GK rats.
  
  
  METHODS
  Twenty 6-8-week-old male GK rats were randomly divided into four groups: group A was operated by Roux-en-Y gastrojejunostomy with duodenum exclusion and stomach capacity maintenance, group B was operated by loop-type gastrojejunostomy with duodenum exclusion and stomach capacity maintenance, group C was operated by Roux-en-Y gastrojejunostomy with partial gastrectomy, and group D was operated by loop-type gastrojejunostomy with partial gastrectomy. Changes of fasting blood glucose, oral glucose tolerance test (OGTT), and insulin tolerance test (ITT) in different operations were detected.
  
  
  RESULTS
  The operations exerted good effects on controlling blood glucose in groups A, B, C, and D. There was no significant difference between groups A and C (P > 0.05) or between groups B and D (P > 0.05), while operations in groups A and C were more effective than groups B and D (P < 0.05). On the 21st day after surgery, OGTT in animals of groups A and C was significantly improved, as indicated by a 34% reduction in the area under the curve (AUC) for blood glucose (P < 0.05 versus groups B and D); pregavage insulin levels (ng/ml) were significantly decreased in groups A and C (P < 0.05 versus groups B and D). The insulin tolerance test (ITT) confirmed impaired insulin sensitivity in groups B and D, compared with groups A and C.
  
  
  CONCLUSIONS
  Gastric bypass surgery might be effective to treat type 2 diabetes mellitus (T2DM), and Roux-en-Y gastrojejunostomy might be more effective than other operative styles.
authors.affiliation: Department of General Surgery, Central Hospital of Fengxian District, 9588 Nan Feng Road, Shanghai 201400, China. zhangxueli_2010@sina.cn
authors.forename: Xueli
authors.initials: X
authors.lastname: Zhang
authors.forename: Wenhai
authors.initials: W
authors.lastname: Huang
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Wenhua
authors.initials: W
authors.lastname: Zhou
authors.forename: Lianming
authors.initials: L
authors.lastname: Zhou
authors.forename: Zhongming
authors.initials: Z
authors.lastname: Huang
authors.forename: Jun
authors.initials: J
authors.lastname: Qu
authors.forename: Ganglong
authors.initials: G
authors.lastname: Gao
authors.forename: Shoujun
authors.initials: S
authors.lastname: Huo
authors.forename: Fanzhi
authors.initials: F
authors.lastname: Kong
authors.forename: Ji-Fa
authors.initials: JF
authors.lastname: Zhang
mesh_terms: D000713:Anastomosis, Roux-en-Y; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000150:complications; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D004386:Duodenum / Q000601:surgery; D015390:Gastric Bypass; D015309:Glucose Clamp Technique; D005951:Glucose Tolerance Test; D007333:Insulin Resistance; D008297:Male; D009765:Obesity / Q000150:complications / Q000601:surgery*; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000601:surgery
chemical_list: D001786:Blood Glucose