title: JC virus antibody and viremia as predictors of progressive multifocal leukoencephalopathy in human immunodeficiency virus-1-infected individuals.
abstract: We examined whether prediagnostic John Cunningham virus (JCV) antibodies and viremia are predictors of progressive multifocal leukoencephalopathy (PML) in 83 PML cases and 240 human immunodeficiency virus (HIV) disease-matched controls. JCV viremia was not predictive of PML, but some patients showed higher anti-JCV immunoglobulin G (IgG) responses 6 months prior to diagnosis.
authors.affiliation: Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. rviscid1@jhmi.edu
authors.forename: Raphael P
authors.initials: RP
authors.lastname: Viscidi
authors.forename: Nina
authors.initials: N
authors.lastname: Khanna
authors.forename: Chen S
authors.initials: CS
authors.lastname: Tan
authors.forename: Xiuhung
authors.initials: X
authors.lastname: Li
authors.forename: Lisa
authors.initials: L
authors.lastname: Jacobson
authors.forename: David B
authors.initials: DB
authors.lastname: Clifford
authors.forename: Avindra
authors.initials: A
authors.lastname: Nath
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Margolick
authors.forename: Keerti V
authors.initials: KV
authors.lastname: Shah
authors.forename: Hans H
authors.initials: HH
authors.lastname: Hirsch
authors.forename: Igor J
authors.initials: IJ
authors.lastname: Koralnik
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000821:virology; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007577:JC Virus / Q000276:immunology / Q000302:isolation & purification*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D014766:Viremia
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G