title: Clinical outcome of non-hCG-primed oocyte in vitro maturation treatment in patients with polycystic ovaries and polycystic ovary syndrome.
abstract: OBJECTIVE
  To compare clinical outcomes of fresh embryo transfer (ET) and vitrified-warmed ET in an artificial endometrial priming cycle in patients with polycystic ovaries (PCO) or polycystic ovary syndrome (PCOS) who underwent oocyte in vitro maturation (IVM) in non-hCG-primed cycles.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  University-based tertiary referral center.
  
  
  METHODS
  Thirty-nine consecutive patients <37 years old with PCO or PCOS, who underwent 73 cycles of immature oocyte retrieval.
  
  
  METHODS
  Immature oocyte collection after ovarian stimulation with a cumulative dose of 450 IU uFSH or highly purified hMG, but without hCG priming. IVM of oocytes followed by ET if endometrium thickness ≥ 6 mm. Embryo vitrification at the cleavage stage. ET in an artificial cycle.
  
  
  METHODS
  Implantation rate (IR) and clinical pregnancy rate (CPR).
  
  
  RESULTS
  Fresh ET after IVM resulted in an IR of 6.9% (5/72) per ET and a CPR of 9.4% (5/53). ET of vitrified-warmed IVM embryos in an artificial cycle resulted in significantly better outcomes (IR 21.9% [7/32] and CPR 31.8% [7/22] per ET).
  
  
  CONCLUSIONS
  A non-hCG-primed IVM system in PCO or PCOS performs poorly when embryos are transfered in a fresh cycle. Transfer of vitrified-warmed IVM embryos in an artificial cycle leads to significantly improved clinical outcomes. These data illustrate that IVM embryos in PCO or PCOS have good survival rates and suggest that hCG may be needed to support endometrial receptivity in the fresh IVM cycle.
authors.affiliation: Center for Reproductive Medicine, Universitair Ziekenhuis Brussel, Brussels, Belgium. mdv@uzbrussel.be
authors.forename: Michel
authors.initials: M
authors.lastname: De Vos
authors.forename: Carolina
authors.initials: C
authors.lastname: Ortega-Hrepich
authors.forename: Firas K
authors.initials: FK
authors.lastname: Albuz
authors.forename: Luis
authors.initials: L
authors.lastname: Guzman
authors.forename: Nikolaos P
authors.initials: NP
authors.lastname: Polyzos
authors.forename: Johan
authors.initials: J
authors.lastname: Smitz
authors.forename: Paul
authors.initials: P
authors.lastname: Devroey
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin; D015331:Cohort Studies; D005260:Female; D006801:Humans; D054315:Oocyte Retrieval / Q000379:methods*; D009865:Oocytes / Q000254:growth & development*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000503:physiopathology*; D011247:Pregnancy; D018873:Pregnancy Rate / Q000639:trends; D011446:Prospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D006063:Chorionic Gonadotropin