title: In vivo remineralising effect of GC tooth mousse on early dental enamel lesions: SEM analysis.
abstract: OBJECTIVE
  Casein phosphopeptide-amorphous calcium phosphate nanocomplexes (CPP-ACP) exhibit anticariogenic potential in laboratory, animal and human experiments. The remineralising potential of synthetic CPPs on early enamel caries was investigated.
  
  
  METHODS
  In vivo study.
  
  
  METHODS
  University of Naples 'Federico II', School of Dentistry, Department of Paediatric Dentistry, 2010, Italy.
  
  
  METHODS
  40 volunteers (age range 10-16 years) were recruited and divided in two groups of 20 (Group A and B).
  
  
  METHODS
  In Group A subjects two demineralised enamel specimens were placed on the buccal surfaces of the first molars and subjects were instructed to apply a commercial product containing CPPs (GC Tooth Mousse) only on the right-sided specimen and a placebo mousse on the left, for 1 month. In Group B subjects two enamel specimens were similarly placed into the mouth and used as controls.
  
  
  RESULTS
  SEM analysis revealed a diffuse and homogeneous mineral coating, reducing the surface alterations only in the demineralised specimens treated with synthetic CPPs into the mouth.
  
  
  CONCLUSIONS
  Results demonstrate that CPPs are able to promote remineralisation of early enamel lesions.
authors.affiliation: Department of Paediatric Dentistry, School of Dentistry, University of Naples 'Federico II', Naples, Italy. gianmariafabrizio@yahoo.it
authors.forename: Gianmaria F
authors.initials: GF
authors.lastname: Ferrazzano
authors.forename: Ivana
authors.initials: I
authors.lastname: Amato
authors.forename: Tiziana
authors.initials: T
authors.lastname: Cantile
authors.forename: Giancarla
authors.initials: G
authors.lastname: Sangianantoni
authors.forename: Aniello
authors.initials: A
authors.lastname: Ingenito
mesh_terms: D000293:Adolescent; D002327:Cariostatic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002364:Caseins / Q000494:pharmacology* / Q000627:therapeutic use; D002648:Child; D003731:Dental Caries / Q000188:drug therapy*; D003743:Dental Enamel / Q000187:drug effects* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008297:Male; D008855:Microscopy, Electron, Scanning; D014089:Tooth Remineralization / Q000379:methods*
chemical_list: D002327:Cariostatic Agents; D002364:Caseins; C447032:casein phosphopeptide-amorphous calcium phosphate nanocomplex