title: Optically stimulated luminescence in vivo dosimetry for radiotherapy: physical characterization and clinical measurements in (60)Co beams.
abstract: A commercial optically stimulated luminescence (OSL) dosimetry system was investigated for in vivo dosimetry in radiation therapy. Dosimetric characteristics of InLight dot dosimeters and a microStar reader (Landauer Inc.) were tested in (60)Co beams. The reading uncertainty of a single dosimeter was 0.6%. The reproducibility of a set of dosimeters after a single irradiation was 1.6%, while in repeated irradiations of the same dosimeters it was found to be 3.5%. When OSL dosimeters were optically bleached between exposures, the reproducibility of repeated measurements improved to 1.0%. Dosimeters were calibrated for the entrance dose measurements and a full set of correction factors was determined. A pilot patient study that followed phantom validation testing included more than 100 measured fields with a mean relative difference of the measured entrance dose from the expected dose of 0.8% and the standard deviation of 2.5%. In conclusion, these results demonstrate that OSL dot dosimeters represent a valid alternative to already established in vivo dosimetry systems.
authors.affiliation: Department of Oncology and Nuclear Medicine, University Hospital 'Sestre milosrdnice', Zagreb, Croatia. iva.mrcela@kbcsm.hr
authors.forename: I
authors.initials: I
authors.lastname: Mrčela
authors.forename: T
authors.initials: T
authors.lastname: Bokulić
authors.forename: J
authors.initials: J
authors.lastname: Izewska
authors.forename: M
authors.initials: M
authors.lastname: Budanec
authors.forename: A
authors.initials: A
authors.lastname: Fröbe
authors.forename: Z
authors.initials: Z
authors.lastname: Kusić
mesh_terms: D000537:Aluminum Oxide / Q000737:chemistry; D003037:Cobalt Radioisotopes / Q000627:therapeutic use*; D006801:Humans; D008163:Luminescent Measurements / Q000295:instrumentation* / Q000379:methods; D055096:Optical Devices; D011874:Radiometry / Q000295:instrumentation* / Q000379:methods; D011878:Radiotherapy / Q000295:instrumentation* / Q000379:methods; D011879:Radiotherapy Dosage; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods; D012680:Sensitivity and Specificity
chemical_list: D003037:Cobalt Radioisotopes; D000537:Aluminum Oxide