title: Evaluation of morbidity and mortality after anastomotic leakage following elective colorectal surgery in patients treated with or without mechanical bowel preparation.
abstract: BACKGROUND
  A previous multicenter randomized trial demonstrated that mechanical bowel preparation (MBP) does not guard against anastomotic leakage in elective colorectal surgery. The aim of this complementary study was to evaluate the effects of MBP on morbidity and mortality after anastomotic leakage in elective colorectal surgery.
  
  
  METHODS
  A subgroup analysis was performed of a randomized trial comparing the incidence of anastomotic leakage and septic complications with and without MBP in patients undergoing elective colorectal surgery.
  
  
  RESULTS
  Elective colorectal surgery was performed in 1,433 patients with primary anastomoses, of whom 63 patients developed anastomotic leakage. Twenty-eight patients (44%) received MBP and 35 patients (56%) did not. Mortality rate, initial need for surgical reintervention, and extent of bowel contamination did not differ between groups (29% vs 40%; P = .497, P = .667, and P = .998, respectively).
  
  
  CONCLUSIONS
  No benefit of MBP was found regarding morbidity and mortality after anastomotic leakage in elective colorectal surgery.
authors.affiliation: Department of Surgery, Ikazia Hospital, Rotterdam, The Netherlands. hpieter44@hotmail.com
authors.forename: Hans Pieter
authors.initials: HP
authors.lastname: van't Sant
authors.forename: Wibo F
authors.initials: WF
authors.lastname: Weidema
authors.forename: Wim C J
authors.initials: WC
authors.lastname: Hop
authors.forename: Johan F
authors.initials: JF
authors.lastname: Lange
authors.forename: Caroline M E
authors.initials: CM
authors.lastname: Contant
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D057868:Anastomotic Leak / Q000209:etiology / Q000401:mortality*; D002316:Cardiotonic Agents / Q000008:administration & dosage; D002400:Cathartics / Q000008:administration & dosage*; D003108:Colonic Diseases / Q000601:surgery*; D015179:Colorectal Neoplasms / Q000601:surgery; D013505:Digestive System Surgical Procedures / Q000009:adverse effects* / Q000401:mortality*; D017558:Elective Surgical Procedures; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D043183:Irritable Bowel Syndrome / Q000601:surgery; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D012002:Rectal Diseases / Q000601:surgery*; D012086:Reoperation / Q000706:statistics & numerical data; D012121:Respiration, Artificial; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D002316:Cardiotonic Agents; D002400:Cathartics