title: Toxocara canis myelitis: clinical features, magnetic resonance imaging (MRI) findings, and treatment outcome in 17 patients.
abstract: Toxocara myelitis is a rare disease. Few cases have been reported in the literature. Patients present with myelopathy, occasional eosinophilia in blood and cerebrospinal fluid (CSF), with abnormal signals on magnetic resonance imaging (MRI). In the current study we report 17 cases of isolated Toxocara myelitis from a single tertiary referral center in Lebanon, with description of the clinical presentation, laboratory data, MRI findings, and response to antihelminthic treatment. Clinical and laboratory data were collected for 17 patients who presented with evidence of spinal cord disease. The clinical presentation included sensory, motor, and autonomic dysfunction, predominantly in the lower extremities. Patients exhibited a subacute or chronic course; this was either slowly progressive or remitting-relapsing with mild to moderate disability. The patients underwent extensive blood and CSF workup as well as MRI of the spinal cord and brain. Only 2 patients had a high eosinophil count in the CSF, although blood eosinophilia was seen in 6 patients. All patients tested positive for Toxocara canis antibodies in the blood and CSF. MRI of the spinal cord revealed a single characteristic lesion in the spinal cord with fusiform enlargement that was isointense on T1-weighted images and hyperintense on T2-weighted images. Nodular enhancement was seen after gadolinium injection. Treatment with albendazole, with or without steroids, resulted in marked neurologic improvement and normalization of the MRI in all patients.The finding of a single inflammatory MRI lesion in the spinal cord with positive Toxocara canis serology in the blood and CSF in cases of subacute or chronic myelitis suggests the diagnosis of Toxocara myelitis, irrespective of the presence of eosinophilia. Antihelminthic treatment is associated with a good outcome.
authors.affiliation: From Neurology Division (RAJ), University of Balamand, Neurology at St George Hospital University Medical Center, Beirut; Infectious Diseases Division (SSK, GNA), Neurology Division (RAS, SFA), and Radiology Department (MHH), American University of Beirut Medical Center, Beirut, Lebanon.
authors.forename: Rosette A
authors.initials: RA
authors.lastname: Jabbour
authors.forename: Souha S
authors.initials: SS
authors.lastname: Kanj
authors.forename: Raja A
authors.initials: RA
authors.lastname: Sawaya
authors.forename: Ghassan N
authors.initials: GN
authors.lastname: Awar
authors.forename: Mukbil H
authors.initials: MH
authors.lastname: Hourani
authors.forename: Samir F
authors.initials: SF
authors.lastname: Atweh
mesh_terms: D000328:Adult; D015766:Albendazole / Q000627:therapeutic use*; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009187:Myelitis / Q000175:diagnosis* / Q000188:drug therapy / Q000469:parasitology; D012189:Retrospective Studies; D017166:Toxocara canis / Q000302:isolation & purification*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000871:Anthelmintics; D005938:Glucocorticoids; D015766:Albendazole