title: Surgical debulking combined with photodynamic therapy to manage residual extramedullary plasmacytoma of the nasopharynx.
abstract: Extramedullary plasmacytomas (EMP) are rare plasma cell neoplasms that are mostly located in the mucosal surfaces of the upper aerodigestive tract. The standard treatment is radiotherapy (RT), with surgical resection reserved as salvage procedure. In this report a patient with a EMP, located in the nasopharynx and refractory to curative RT. Because of the technical difficulty of a radical resection in the nasopharynx area the EMP is managed by endoscopic debulking and temoporfin mediated photodynamic therapy. The patient remains disease free since six years.
authors.affiliation: The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. b.karakullukcu@nki.nl
authors.forename: Baris
authors.initials: B
authors.lastname: Karakullukcu
authors.forename: Jan Paul
authors.initials: JP
authors.lastname: De Boer
authors.forename: Robert
authors.initials: R
authors.lastname: Van Veen
authors.forename: Jurgen
authors.initials: J
authors.lastname: Wegman
authors.forename: Bing
authors.initials: B
authors.lastname: Tan
mesh_terms: D018572:Disease-Free Survival; D004724:Endoscopy / Q000379:methods; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008652:Mesoporphyrins / Q000627:therapeutic use; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D020360:Neoadjuvant Therapy; D018365:Neoplasm, Residual / Q000188:drug therapy; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D010954:Plasmacytoma / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D011879:Radiotherapy Dosage; D012074:Remission Induction
chemical_list: D008652:Mesoporphyrins; D017319:Photosensitizing Agents; C072269:temoporfin