title: Serous adenocarcinoma of the uterine cervix: a clinicopathological study of 12 cases and a review of the literature.
abstract: OBJECTIVE
  To determine the clinicopathological characteristics and potentially associated outcomes in patients diagnosed with serous adenocarcinoma of the uterine cervix.
  
  
  METHODS
  The records of surgically-treated patients with pathological stage pT1b-2b serous adenocarcinoma were reviewed.
  
  
  RESULTS
  Of 12 patients with serous adenocarcinoma who underwent radical hysterectomy, five had pT1b1N0 disease, two pT1b1N1, two pT1b2N0, and three pT2bN1. The 5-year overall survival rate for patients with or without parametrial involvement (pT2b vs. pT1b) was 0 and 89%, respectively. The 3-year recurrence-free survival rate for those with or without parametrial involvement was 33 and 89%, respectively. Four patients suffered recurrence, namely one of those who had pT1b (1/9, 11%) and 3 of those who had pT2b disease (100%). The sites of recurrence of pT2b disease were outside the pelvis in all 3 patients. Of these, 2 (67%) had peritoneal spread and 1 distant node metastasis.
  
  
  CONCLUSIONS
  While patients with pathological stage pT1b disease may have a relatively favorable outcome after radical surgery, those with more advanced disease have a poor prognosis because of extra-pelvic recurrence.
authors.affiliation: Division of Gynecology, National Cancer Center Hospital, Tokyo, Japan. stogami@ncc.go.jp
authors.forename: Shinichi
authors.initials: S
authors.lastname: Togami
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kasamatsu
authors.forename: Yuko
authors.initials: Y
authors.lastname: Sasajima
authors.forename: Takashi
authors.initials: T
authors.lastname: Onda
authors.forename: Mitsuya
authors.initials: M
authors.lastname: Ishikawa
authors.forename: Shun-ichi
authors.initials: S
authors.lastname: Ikeda
authors.forename: Tomoyasu
authors.initials: T
authors.lastname: Kato
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Tsuda
mesh_terms: D000328:Adult; D000368:Aged; D018284:Cystadenocarcinoma, Serous / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy; D008207:Lymphatic Metastasis; D008875:Middle Aged; D060787:Neoplasm Grading; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D002583:Uterine Cervical Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery