title: Obese adolescents with eating disorders: analysis of metabolic and inflammatory states.
abstract: OBJECTIVE
  The purpose of the present investigation was to compare the effect of interdisciplinary therapy on the physical and metabolic profiles, including body composition, insulin resistance and sensitivity as well as adiponectin and leptin concentrations, of obese adolescents with and without eating disorder symptoms.
  
  
  METHODS
  A total of 83 obese adolescents (28 with and 55 without eating disorder symptoms) were enrolled for 1 year of interdisciplinary weight-loss therapy (clinical, nutritional, exercise, physiotherapy and psychological). Bulimic and binge eating symptoms were measured by the Bulimic Investigatory Test, Edinburgh, and the Binge Eating Scale, respectively. Leptin and adiponectin concentrations were measured with enzyme-linked immunosorbent assay kits. Visceral and subcutaneous fat were assessed by ultrasonography.
  
  
  RESULTS
  Both groups demonstrated improved body mass, body mass index, body fat (%), lean mass, visceral fat, subcutaneous fat, homeostasis model assessment insulin-resistance index (HOMA-IR), quantitative insulin sensitivity check index, total cholesterol, LDL-cholesterol, VLDL, triglycerides, adiponectin and leptin concentrations after therapy. We found a positive correlation between leptin concentrations and subcutaneous fat in the control group and a negative correlation between adiponectin concentrations and HOMA-IR and fat mass (%). The prevalence of obese adolescents with eating disorders was reduced by 89% after 1 year of interdisciplinary therapy.
  
  
  CONCLUSIONS
  The eating disorder symptoms did not impair the metabolic state during weight loss therapy of obese adolescents. Additionally, long-term interdisciplinary therapy was effective in reducing the chances of developing several co-morbidities in both groups.
authors.affiliation: Post Graduate Program of Nutrition, São Paulo, Brazil. junecarnier@gmail.com
authors.forename: June
authors.initials: J
authors.lastname: Carnier
authors.forename: Priscila de Lima
authors.initials: Pde L
authors.lastname: Sanches
authors.forename: Patrícia Leão
authors.initials: PL
authors.lastname: da Silva
authors.forename: Aline
authors.initials: A
authors.lastname: de Piano
authors.forename: Lian
authors.initials: L
authors.lastname: Tock
authors.forename: Raquel M S
authors.initials: RM
authors.lastname: Campos
authors.forename: Flávia C
authors.initials: FC
authors.lastname: Corgosinho
authors.forename: Fabíola Alvise
authors.initials: FA
authors.lastname: Corrêa
authors.forename: Deborah
authors.initials: D
authors.lastname: Masquio
authors.forename: Claudia Maria Oller
authors.initials: CM
authors.lastname: do Nascimento
authors.forename: Lila Missae
authors.initials: LM
authors.lastname: Oyama
authors.forename: Regina H
authors.initials: RH
authors.lastname: Ernandes
authors.forename: Marco Túlio
authors.initials: MT
authors.lastname: de Mello
authors.forename: Sérgio
authors.initials: S
authors.lastname: Tufik
authors.forename: Ana R
authors.initials: AR
authors.lastname: Dâmaso
mesh_terms: D000273:Adipose Tissue; D000293:Adolescent; D000704:Analysis of Variance; D015992:Body Mass Index; D002784:Cholesterol; D001068:Feeding and Eating Disorders / Q000453:epidemiology / Q000378:metabolism* / Q000503:physiopathology* / Q000628:therapy; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism* / Q000628:therapy; D008297:Male; D009765:Obesity / Q000453:epidemiology / Q000378:metabolism* / Q000503:physiopathology* / Q000628:therapy; D026741:Physical Therapy Modalities; D011613:Psychotherapy; D014280:Triglycerides; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D014280:Triglycerides; D002784:Cholesterol