title: Management and outcomes of three cases of rhinocerebral mucormycosis.
abstract: Mucormycosis is a rare opportunistic infection caused by fungi belonging to Mucorales order. The infection usually starts in the middle or inferior nasal meatus and then spreads to the paranasal sinuses and the orbit. Then it reaches the brain through the ethmoid and the orbit apex and can lead to lethargy, paralysis, and death. The majority of cases of rhinocerebral mucormycosis are diagnosed in patients with immunologic and metabolic disorders. Early diagnosis is fundamental, and so is medical therapy with amphotericin B along with surgical toilet of the compromised tissues. This article presents and discusses the management of 3 cases of rhinocerebral mucormycosis with different onsets, progressions, and outcomes.
authors.affiliation: Division of Maxillofacial Surgery, Head and Neck Department, San Giovanni Battista Hospital, University of Turin, Turin, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Viterbo
authors.forename: Massimo
authors.initials: M
authors.lastname: Fasolis
authors.forename: Paolo
authors.initials: P
authors.lastname: Garzino-Demo
authors.forename: Alessandro
authors.initials: A
authors.lastname: Griffa
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffano
authors.forename: Caterina
authors.initials: C
authors.lastname: Iaquinta
authors.forename: Giulia
authors.initials: G
authors.lastname: Tanteri
authors.forename: Remo
authors.initials: R
authors.lastname: Modica
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D001927:Brain Diseases / Q000382:microbiology* / Q000628:therapy; D020314:Central Nervous System Fungal Infections / Q000628:therapy*; D004724:Endoscopy / Q000379:methods; D005094:Exophthalmos / Q000382:microbiology; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000628:therapy*; D009187:Myelitis / Q000382:microbiology; D009668:Nose Diseases / Q000382:microbiology*; D009894:Opportunistic Infections / Q000382:microbiology; D019226:Oral Ulcer / Q000382:microbiology; D010254:Paranasal Sinus Diseases / Q000382:microbiology* / Q000628:therapy; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000935:Antifungal Agents