title: The re-infection rate of high-risk HPV and the recurrence rate of vulvar intraepithelial neoplasia (VIN) usual type after surgical treatment.
abstract: BACKGROUND
  VIN usual type appears to be related to the HPV's oncogenic types. The aim of this prospective multicenter study was to evaluate the re-infection rate of high-risk HPV and the recurrence rate of VIN usual type after surgical treatment.
  
  
  METHODS
  The study enrolled 103 women affected by VIN usual type. They underwent wide local excision by CO2 laser. The patients were investigated by clinical evaluation and HPV DNA test 6 months after surgical treatment, and then were followed-up at 12, 18, 24, and 36 months. The recurrences were treated with re-excision.
  
  
  RESULTS
  The rate of HPV infection after surgical treatment was 34% at 6 months, 36.9% at 12 months, 40% at 18 months, 41.7% at 24 months and 44.7% at 36 months. The mean time from HPV infection to the development of VIN was 18.8 months.
  
  
  CONCLUSIONS
  HPV testing in the follow-up of VIN usual type patients might be useful for identifying those patients with a higher risk of recurrence after surgical treatment, although more studies are needed. These preliminary data suggest that the test, in addition to clinical examination, can improve the efficacy of the follow-up.
authors.affiliation: Department of Woman's Health and Territorial Medicine, Faculty of Medicine and Psychology Sapienza University of Rome, Rome, Italy. a.frega@tin.it
authors.forename: Antonio
authors.initials: A
authors.lastname: Frega
authors.forename: Francesco
authors.initials: F
authors.lastname: Sopracordevole
authors.forename: Paolo
authors.initials: P
authors.lastname: Scirpa
authors.forename: Alberto
authors.initials: A
authors.lastname: Biamonti
authors.forename: Laura
authors.initials: L
authors.lastname: Lorenzon
authors.forename: Simona
authors.initials: S
authors.lastname: Scarani
authors.forename: Luana
authors.initials: L
authors.lastname: De Sanctis
authors.forename: Arianna
authors.initials: A
authors.lastname: Pacchiarotti
authors.forename: Massimo
authors.initials: M
authors.lastname: Moscarini
authors.forename: Deborah
authors.initials: D
authors.lastname: French
mesh_terms: D000328:Adult; D002278:Carcinoma in Situ / Q000453:epidemiology / Q000601:surgery* / Q000821:virology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008875:Middle Aged; D027383:Papillomaviridae / Q000502:physiology*; D030361:Papillomavirus Infections / Q000601:surgery* / Q000821:virology*; D012008:Recurrence; D012307:Risk Factors; D014846:Vulvar Neoplasms / Q000453:epidemiology / Q000601:surgery* / Q000821:virology*; D055815:Young Adult