title: Termination of protein synthesis in mammalian mitochondria.
abstract: All mechanisms of protein synthesis can be considered in four stages: initiation, elongation, termination, and ribosome recycling. Remarkable progress has been made in understanding how these processes are mediated in the cytosol of many species; however, details of organellar protein synthesis remain sketchy. This is an important omission, as defects in human mitochondrial translation are known to cause disease and may contribute to the aging process itself. In this minireview, we focus on the recent advances that have been made in understanding how one of these processes, translation termination, occurs in the human mitochondrion.
authors.affiliation: Mitochondrial Research Group, Institute for Ageing and Health, Newcastle University, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom.
authors.forename: Zofia M A
authors.initials: ZM
authors.lastname: Chrzanowska-Lightowlers
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Pajak
authors.forename: Robert N
authors.initials: RN
authors.lastname: Lightowlers
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism; D003062:Codon; D018388:Codon, Terminator; D019295:Computational Biology / Q000379:methods; D005656:Fungal Proteins / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D008954:Models, Biological; D008957:Models, Genetic; D016366:Open Reading Frames; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000378:metabolism; D012270:Ribosomes / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D003062:Codon; D018388:Codon, Terminator; D005656:Fungal Proteins; D012333:RNA, Messenger