title: Microarray analysis of tonsils of IgA nephropathy patients.
abstract: IgA nephropathy (IgAN) is the most common primary glomerulonephritis. Its close relation with the tonsils is well known because tonsillitis sometimes causes aggravation of urinary findings or macrohematuria. However, the genes specific to the tonsils of IgAN patients are not clarified. To clarify the specific gene expression in the tonsils of IgAN patients, we performed tonsillectomy and corticosteroid IV therapy as a treatment of IgAN, analyzed the gene expression in the tonsils by microarray and compared it with that in tonsils from chronic tonsillitis patients. The upregulated genes seem to be categorized into two groups: muscle-related genes and immunerelated genes. The downregulated genes include the polymeric Ig receptor (pIgR) which was reportedly involved in single nucleotide polymorphism (SNP) of Japanese IgAN patients.
authors.affiliation: Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan. hiro@kid.med.osaka-u.ac.jp
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Iwatani
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Iio
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Nagasawa
authors.forename: Ryohei
authors.initials: R
authors.lastname: Yamamoto
authors.forename: Arata
authors.initials: A
authors.lastname: Horii
authors.forename: Daisuke
authors.initials: D
authors.lastname: Okuzaki
authors.forename: Hidenori
authors.initials: H
authors.lastname: Inohara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nojima
authors.forename: Enyu
authors.initials: E
authors.lastname: Imai
authors.forename: Hiromi
authors.initials: H
authors.lastname: Rakugi
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Isaka
mesh_terms: D000328:Adult; D064032:Calbindin 2; D054371:Chemokine CXCL11 / Q000096:biosynthesis / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D005922:Glomerulonephritis, IGA / Q000209:etiology / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018995:Myosin Heavy Chains / Q000096:biosynthesis / Q000235:genetics; D014066:Palatine Tonsil / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D010749:Phosphoprotein Phosphatases / Q000096:biosynthesis / Q000235:genetics; D016133:Polymerase Chain Reaction; D011379:Prognosis; D012313:RNA / Q000235:genetics*; D012189:Retrospective Studies; D064030:S100 Calcium Binding Protein G / Q000096:biosynthesis / Q000235:genetics; D046888:Tissue Array Analysis / Q000379:methods*; D014069:Tonsillitis / Q000150:complications / Q000235:genetics* / Q000378:metabolism; D055815:Young Adult
chemical_list: C515202:CXCL11 protein, human; D064032:Calbindin 2; D054371:Chemokine CXCL11; D064030:S100 Calcium Binding Protein G; D012313:RNA; D010749:Phosphoprotein Phosphatases; C522887:STYXL2 protein, human; D018995:Myosin Heavy Chains