title: Variations in the fat mass and obesity-associated (FTO) gene are related to glucose levels and higher lipid accumulation product in postmenopausal women from southern Brazil.
abstract: OBJECTIVE
  To test the association between polymorphisms rs9939609 T>A and rs8050136 A>C of the fat mass and obesity-associated (FTO) gene and metabolic and cardiovascular variables in postmenopause.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  A total of 135 postmenopausal women (mean age 52 ± 4 years).
  
  
  METHODS
  Anthropometric measurements and collection of blood samples.
  
  
  METHODS
  Blood pressure, metabolic variables, and FTO genotype.
  
  
  RESULTS
  The frequency of polymorphism rs9939609 was 43.7% for the wild TT genotype, 43.0% for TA, and 13.3% for AA. The frequency of the rs8050136 polymorphism was 12.6% for the wild AA genotype, 39.3% for AC, and 48.1% for CC. The polymorphic AA genotype of the SNP rs9939609 was associated with higher glucose levels and lipid accumulation product (LAP) index, whereas the wild AA genotype of the SNP rs8050136 was associated with higher LAP.
  
  
  CONCLUSIONS
  The rs9939609 polymorphism in the FTO gene is related to abnormal glucose levels and with LAP, a surrogate marker of diabetes and cardiovascular risk in postmenopause. Further studies are needed in different ethnic backgrounds to confirm the clinical relevance of these associations.
authors.affiliation: Gynecologic Endocrinology Unit, Division of Endocrinology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Ramon Bossardi
authors.initials: RB
authors.lastname: Ramos
authors.forename: Gislaine Krolow
authors.initials: GK
authors.lastname: Casanova
authors.forename: Maria Augusta
authors.initials: MA
authors.lastname: Maturana
authors.forename: Poli Mara
authors.initials: PM
authors.lastname: Spritzer
mesh_terms: D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D000886:Anthropometry / Q000379:methods; D001786:Blood Glucose / Q000235:genetics* / Q000378:metabolism*; D050218:Body Fat Distribution / Q000379:methods; D001938:Brazil / Q000208:ethnology; D003430:Cross-Sectional Studies; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D009765:Obesity; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D017698:Postmenopause / Q000097:blood* / Q000208:ethnology / Q000235:genetics*; D011506:Proteins / Q000235:genetics*
chemical_list: D001786:Blood Glucose; D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human