title: Synthesis of well-dispersed layered double hydroxide core@ordered mesoporous silica shell nanostructure (LDH@mSiO₂) and its application in drug delivery.
abstract: We demonstrate an efficient synthesis of novel layered double hydroxide mesoporous silica core-shell nanostructures (LDH@mSiO(2)) that have a hexagonal MgAl-LDH nanoplate core and an ordered mesoporous silica shell with perpendicularly oriented channels via a surfactant-templating method. Transmission electron microscopy, X-ray diffraction and N(2) sorption analyses confirmed that the obtained nanostructures have uniform accessible mesopores (∼2.2 nm), high surface area (∼430 m(2) g(-1)), and large pore volume (∼0.22 cm(3) g(-1)). Investigations of drug release and bio-imaging showed that this material has a slow release effect of ibuprofen and good biocompatibility. This work provides an economical approach to fabricate LDH@mSiO(2) core-shell nanostructures, which may have great potential in broad drug delivery and hyperthermia therapy applications.
authors.affiliation: College of Materials, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, Zhejiang 310036, P. R. China.
authors.forename: Haifeng
authors.initials: H
authors.lastname: Bao
authors.forename: Jianping
authors.initials: J
authors.lastname: Yang
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.forename: Zhi Ping
authors.initials: ZP
authors.lastname: Xu
authors.forename: Na
authors.initials: N
authors.lastname: Hao
authors.forename: Zhangxiong
authors.initials: Z
authors.lastname: Wu
authors.forename: Gao Qing Max
authors.initials: GQ
authors.lastname: Lu
authors.forename: Dongyuan
authors.initials: D
authors.lastname: Zhao
mesh_terms: D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D006878:Hydroxides / Q000737:chemistry*; D018613:Microscopy, Confocal; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D004337:Drug Carriers; D006878:Hydroxides; D013501:Surface-Active Agents; D012822:Silicon Dioxide