title: Implication of CKD-EPI equation to estimate glomerular filtration rate in Chinese patients with chronic kidney disease.
abstract: OBJECTIVE
  To evaluate the applicability of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation to estimate glomerular filtration rate (GFR) in Chinese patients of different stages of CKD.
  
  
  METHODS
  The CKD-EPI equation estimated GFR (eGFR) was compared with body surface area standardized GFR (sGFR), which was measured by diethylenetriaminepentaacetic acid renal dynamic imaging method in 142 CKD cases.
  
  
  RESULTS
  eGFR was positively correlated with sGFR (r = 0.838, p < 0.001). eGFR of 15%, 30%, and 50% accuracy were 31.0%, 57.7%, and 76.8%, respectively. Average deviation of eGFR from sGFR was -0.92 ± 16.36 mL/min/1.73 m2 (p = 0.506). There was no significant deviation in the CKD from stages 2 to 5. However, in CKD stage 1, the deviation was increased with the value of 13.36 ± 18.44 mL/min/1.73 m(2) (p = 0.023).
  
  
  CONCLUSIONS
  CKD-EPI equation might be widely used in evaluation of Chinese CKD patients of different stages, with a less deviation and higher accuracy. However, in CKD stage 1, eGFR was higher than sGFR on average. It was suggested that eGFR might be overcorrected or overestimated. These results demonstrated that careful modification of CKD-EPI equation would be necessary in Chinese populations with CKD.
authors.affiliation: Department of Nephrology, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing, PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: Du
authors.forename: Bo
authors.initials: B
authors.lastname: Hu
authors.forename: Linglin
authors.initials: L
authors.lastname: Jiang
authors.forename: Xin
authors.initials: X
authors.lastname: Wan
authors.forename: Li
authors.initials: L
authors.lastname: Fan
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.forename: Changchun
authors.initials: C
authors.lastname: Cao
mesh_terms: D017677:Age Distribution; D000368:Aged; D001830:Body Surface Area; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis* / Q000453:epidemiology*; D018570:Risk Assessment; D012720:Severity of Illness Index; D017678:Sex Distribution