title: Infliximab in Crohn's disease-associated toxic megacolon.
abstract: Refractory medical treatment of Crohn disease-associated toxic megacolon usually requires surgery, which carries substantial morbidity and mortality. We report a case of a woman with steroid and antibiotic-refractory fulminant Crohn colitis and ileitis, complicated by a toxic megacolon, who was successfully treated with infliximab. Infliximab induced rapid clinical response and remission, thereby avoiding emergency (ileo) colectomy. This is the first report of treatment of Crohn disease-associated toxic megacolon with infliximab.
authors.affiliation: Department of Gastroenterology and Hepatology, Bronovo Teaching Hospital, The Hague. ejmvgeenen@bronovo.nl
authors.forename: Erwin-Jan M
authors.initials: EJ
authors.lastname: van Geenen
authors.forename: David B
authors.initials: DB
authors.lastname: Sachar
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D003424:Crohn Disease / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D000069285:Infliximab; D008532:Megacolon, Toxic / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D005765:Gastrointestinal Agents; D000069285:Infliximab