title: [From the flight of Iu. A. Gagarin to the contemporary piloted space flights and exploration missions].
abstract: The first human flight to space made by Yu. A. Gagarin on April 12, 1961 was a crucial event in the history of cosmonautics that had a tremendous effect on further progress of the human civilization. Gagarin's flight had been prefaced by long and purposeful biomedical researches with the use of diverse bio-objects flown aboard rockets and artificial satellites. Data of these researches drove to the conclusion on the possibility in principle for humans to fly to space. After a series of early flights and improvements in the medical support system space missions to the Salyut and Mir station gradually extended to record durations. The foundations of this extension were laid by systemic researches in the fields of space biomedicine and allied sciences. The current ISS system of crew medical care has been successful in maintaining health and performance of cosmonauts as well as in providing the conditions for implementation of flight duties and operations with a broad variety of payloads. The ISS abounds in opportunities of realistic trial of concepts and technologies in preparation for crewed exploration missions. At the same, ground-based simulation of a mission to Mars is a venue for realization of scientific and technological experiments in space biomedicine.
authors.forename: A I
authors.initials: AI
authors.lastname: Grigor'ev
authors.forename: A N
authors.initials: AN
authors.lastname: Potapov
mesh_terms: D000337:Aerospace Medicine / Q000266:history*; D049673:History, 20th Century; D006801:Humans; D013026:Space Flight / Q000266:history*; D014586:USSR