title: Influence of chitosan coating on the liposomal surface on physicochemical properties and the release profile of nanocarrier systems.
abstract: Chitosan-coated nanoliposomes containing etofenprox or alpha-cypermethrin prepared by ultrasonic homogenization maintained a size distribution in the nanometre range. Nanoliposomes were constructed using different types and concentrations of chitosan to regulate the mean size and surface charge. As the chitosan concentration (0.1-0.5%, w/v) and the degree of deacetylation increased, surface charge also increased. The encapsulation efficiency and release profile were measured by gas chromatography. Encapsulation efficiency decreased slightly as chitosan concentration increased (0.1-0.5%, w/v). As the intrinsic surface charge or concentration of the coating material increased, the release period of the entrapped core material was extended (chitosans A and B; 0.1 and 0.3%, w/v). The results indicate that diverse preparation conditions could affect the physicochemical properties and release profile of the resulting nanocarrier systems.
authors.affiliation: School of Life Sciences and Biotechnology, Korea University, Seoul, South Korea.
authors.forename: S H
authors.initials: SH
authors.lastname: Bang
authors.forename: I C
authors.initials: IC
authors.lastname: Hwang
authors.forename: Y M
authors.initials: YM
authors.lastname: Yu
authors.forename: H R
authors.initials: HR
authors.lastname: Kwon
authors.forename: D H
authors.initials: DH
authors.lastname: Kim
authors.forename: H J
authors.initials: HJ
authors.lastname: Park
mesh_terms: D000107:Acetylation; D048271:Chitosan / Q000737:chemistry*; D002849:Chromatography, Gas; D003692:Delayed-Action Preparations; D004339:Drug Compounding / Q000379:methods*; D008081:Liposomes / Q000737:chemistry*; D008863:Microspheres; D053769:Nanocapsules / Q000737:chemistry*; D010316:Particle Size; D010713:Phosphatidylcholines / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D003692:Delayed-Action Preparations; D008081:Liposomes; D053769:Nanocapsules; D010713:Phosphatidylcholines; D048271:Chitosan