title: Hepatitis C therapy: other players in the game.
abstract: Therapies in addition to the direct-acting antiviral agents (DAA) under evaluation for chronic hepatitis C include host targets such as cyclophilin inhibitors and immunomodulators. Both passive and therapeutic vaccines hold promise for the future. Although the numbers of drug categories and individual agents are increasing, only a handful of the non-DAAs seem to be ready to move on to phase III trials. New interferon agents are in development, and ribavirin variants are still under consideration. The role of the other players in the overall armamentarium against hepatitis C virus is still evolving.
authors.affiliation: Loyola University Medical Center, Maywood, IL 60153, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Ahn
authors.forename: Steven L
authors.initials: SL
authors.lastname: Flamm
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D021983:Cyclophilins / Q000037:antagonists & inhibitors; D055808:Drug Discovery; D006526:Hepatitis C / Q000188:drug therapy*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D014611:Vaccination
chemical_list: D000911:Antibodies, Monoclonal; D000998:Antiviral Agents; D007155:Immunologic Factors; D021983:Cyclophilins; C547825:bavituximab