title: Optimization of topical gels with betamethasone dipropionate: selection of gel forming and optimal cosolvent system.
abstract: The purpose of these studies was to develop a 0.05% betamethasone gel characterized by physical-chemical stability and good release properties. The preliminary studies were designed to select the gel-forming agents and the excipients compatible with betamethasone dipropionate. In order to formulate a clear gel without particles of drug substances in suspension, a solvent system for the drug substance was selected. The content of drug substance released, the rheological and in vitro release tests were the tools used for the optimal formulation selection. A stable carbomer gel was obtained by solubilization of betamethasone dipropionate in a vehicle composed by 40% PEG 400, 10% ethanol and 5% Transcutol.
authors.affiliation: Research and Development Department, Antibiotice SA, Iaşi, Romania Gr. T. Popa University of Medicine and Pharmacy Iaşi School of Pharmacy.
authors.forename: Mariana
authors.initials: M
authors.lastname: Băiţan
authors.forename: Mihaela
authors.initials: M
authors.lastname: Lionte
authors.forename: Lăcrămioara
authors.initials: L
authors.lastname: Moisuc
authors.forename: Eliza
authors.initials: E
authors.lastname: Gafiţanu
mesh_terms: D000279:Administration, Cutaneous; D001623:Betamethasone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D004338:Drug Combinations; D000431:Ethanol / Q000138:chemical synthesis; D005026:Ethylene Glycols / Q000138:chemical synthesis; D005782:Gels / Q000138:chemical synthesis; D009824:Ointments / Q000008:administration & dosage / Q000138:chemical synthesis; D011092:Polyethylene Glycols / Q000138:chemical synthesis; D012997:Solvents / Q000138:chemical synthesis*
chemical_list: D003879:Dermatologic Agents; D004338:Drug Combinations; D005026:Ethylene Glycols; D005782:Gels; D009824:Ointments; D012997:Solvents; D000431:Ethanol; D011092:Polyethylene Glycols; C011175:betamethasone-17,21-dipropionate; D001623:Betamethasone; C010111:carbitol