title: Hydrazidomycins, cytotoxic alkylhydrazides from Streptomycesatratus.
abstract: Three unusual alkyhydrazide natural products, named hydrazidomycin A (1), B (2) and C (3), were isolated from the chloroform extract of a Streptomycesatratus culture, and their structures were elucidated by MS and NMR techniques. Hydrazidomycins A-C exhibited moderate to strong cytotoxic activities in a panel of 42 cell lines, with hydrazidomycin A being the most potent compound (mean IC(50)=0.37 μM).
authors.affiliation: Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstr, 11a, D-07745 Jena, Germany.
authors.forename: Nico
authors.initials: N
authors.lastname: Ueberschaar
authors.forename: Basile Le Sage Tchize
authors.initials: Ble S
authors.lastname: Ndejouong
authors.forename: Ling
authors.initials: L
authors.lastname: Ding
authors.forename: Armin
authors.initials: A
authors.lastname: Maier
authors.forename: Heinz-Herbert
authors.initials: HH
authors.lastname: Fiebig
authors.forename: Christian
authors.initials: C
authors.lastname: Hertweck
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D055808:Drug Discovery; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D006834:Hydrazines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008297:Male; D015394:Molecular Structure; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000903:Antibiotics, Antineoplastic; D006834:Hydrazines; C571359:hydrazidomycin A