title: Intramolecular aryne-ene reaction: synthetic and mechanistic studies.
abstract: Although the chemistry of arynes is well developed, some challenges still remain. The ene reaction of arynes has not gained widespread use in synthesis as a result of poor yields and selectivity. A general, high yielding and selective intramolecular aryne-ene reaction is described providing various benzofused carbo- and heterocycles. Mechanistic data is presented, and a rationale for the resulting stereochemistry is discussed.
authors.affiliation: Department of Chemistry, University of Toronto, 80 Saint George Street, Toronto, Ontario M5S 3H6, Canada.
authors.forename: David A
authors.initials: DA
authors.lastname: Candito
authors.forename: Jane
authors.initials: J
authors.lastname: Panteleev
authors.forename: Mark
authors.initials: M
authors.lastname: Lautens
mesh_terms: D009930:Organic Chemicals / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009930:Organic Chemicals