title: Automated quantitative FLAIR analysis in hippocampal sclerosis.
abstract: OBJECTIVE
  To describe and evaluate a novel MRI post-processing technique for automated quantitative hippocampal FLAIR analysis in patients with hippocampal sclerosis (HS).
  
  
  METHODS
  Based on a method for FLAIR analysis presented by Focke et al. (2009), T1 and coregistered FLAIR scans of individual subjects were processed together in SPM5 to conduct both a spatial and an intensity normalization of the FLAIR scans. In a further development described here, the resulting normalized FLAIR images were thresholded and weighted by a probabilistic hippocampal mask to determine the average FLAIR intensities of left and right hippocampus. The method was applied to the MRI data of 103 HS patients and 131 controls. Using a 95% confidence region calculated from the FLAIR intensities of controls as threshold, the performance in discriminating both groups was assessed.
  
  
  RESULTS
  One hundred of 103 patients and among those all 23 patients with histologically confirmed HS fell outside the 95% confidence region, amounting to 97.1% sensitivity. All but 6 controls (=95.4%) were found within the confidence region, corresponding to the expected specificity. The method could also distinguish bilateral HS and visualize signal changes after status epilepticus.
  
  
  CONCLUSIONS
  Automated FLAIR analysis is a promising tool to quantify hippocampal signal alterations, to support the detection of HS, and to monitor the temporal evolution of the disease.
authors.affiliation: Swiss Epilepsy Centre, Bleulerstrasse 60, 8008 Zürich, Switzerland. hans-juergen.huppertz@swissepi.ch
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Huppertz
authors.forename: Jan
authors.initials: J
authors.lastname: Wagner
authors.forename: Bernd
authors.initials: B
authors.lastname: Weber
authors.forename: Patrick
authors.initials: P
authors.lastname: House
authors.forename: Horst
authors.initials: H
authors.lastname: Urbach
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D018450:Disease Progression; D004828:Epilepsies, Partial / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000592:standards*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012598:Sclerosis; D012680:Sensitivity and Specificity; D055815:Young Adult