title: Antioxidant and anti-inflammatory effects of Scoparia dulcis L.
abstract: Different extracts were obtained from Scoparia dulcis L. (Scrophulariaceae) by successive extraction with hexane, chloroform, and methanol. These extracts exhibited significant antioxidant capacity in various antioxidant models mediated (xantine oxidase and lipoxygenase) or not mediated (2,2-diphenyl-picrylhydrazyl, ferric-reducing antioxidant power, β-carotene bleaching, lipid peroxidation) by enzymes. The antioxidant activity of the extracts was related to their phytochemical composition in terms of polyphenol and carotenoid contents. The chloroform extract was richest in phytochemicals and had the highest antioxidant activity in the different antioxidant systems. All the extracts exhibited less than 50% inhibition on xanthine oxidase but more than 50% inhibition on lipid peroxidation and lipoxygenase. The extracts strongly inhibited lipid peroxidation mediated by lipoxygenase.
authors.affiliation: Laboratories of Biochemistry & Applied Chemistry (Labioca), University of Ouagadougou, Ouagadougou, Burkina Faso. coulahmede@yahoo.fr
authors.forename: Ahmed Y
authors.initials: AY
authors.lastname: Coulibaly
authors.forename: Martin
authors.initials: M
authors.lastname: Kiendrebeogo
authors.forename: Patrick G
authors.initials: PG
authors.lastname: Kehoe
authors.forename: Pierre A E D
authors.initials: PA
authors.lastname: Sombie
authors.forename: Charles E
authors.initials: CE
authors.lastname: Lamien
authors.forename: Jeanne F
authors.initials: JF
authors.lastname: Millogo
authors.forename: Odile G
authors.initials: OG
authors.lastname: Nacoulma
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D002338:Carotenoids / Q000032:analysis; D006586:Hexanes / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D016859:Lipoxygenase Inhibitors / Q000378:metabolism; D000077276:Lycopene; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D036721:Scoparia / Q000737:chemistry*; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors / Q000378:metabolism; D019207:beta Carotene / Q000032:analysis
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D006586:Hexanes; D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts; D019207:beta Carotene; C026385:n-hexane; D002338:Carotenoids; D014969:Xanthine Oxidase; D000077276:Lycopene