title: [Expression of deleted in liver cancer 1 and phosphorelated focal adhesion kinase in breast cancer].
abstract: OBJECTIVE
  To analyze the expression of deleted in liver cancer 1 (DLC1) and phosphorelated focal adhesion kinase (p-FAK) in breast cancer tissue to further understand the molecular mechanisms of the carcinogenesis and metastasis of breast cancer.
  
  
  METHODS
  Immunohistochemistry was employed to determine the protein level of DLC1 and p-FAK in 61 breast cancer, 30 benign breast disease and the adjacent normal breast tissues.
  
  
  RESULTS
  The positivity rates of DLC1 differed significantly between breast cancer, benign and normal tissues (34.43%, 80.00% and 76.67%, respectively, P<0.001). The positivity rates of p-FAK in the 3 tissues were 77.05%, 33.33% and 26.67%, also showing significant differences (P<0.001). The aberrant expression of DLC1 showed an inverse correlation to p-FAK (κ=-0.4591). Both DLC1 and p-FAK were closely correlated to the carcinogenesis, clinical stage, PR and lymphatic metastasis of breast cancer (P<0.05), but not to the patients age, pathological subtype, familial history, ER or CerbB-2 (P>0.05).
  
  
  CONCLUSIONS
  The abnormal expression of DLC1 and p-FAK might participate in the carcinogenesis, progression, and metastasis of breast cancer. The role of DLC1 and p-FAK might be related to the regulation of progestone. DLC1 and p-FAK may serve as candidate markers for early diagnosis, prognostic evaluation and target treatment of breast cancer.
authors.affiliation: Department of Thyroid and Breast Surgery, Luoyang Central Hospital, Luoyang 471009, China. E-mail: fyfdm@tom.com.
authors.forename: Yun
authors.initials: Y
authors.lastname: Feng
authors.forename: Hui-xing
authors.initials: HX
authors.lastname: Zhou
authors.forename: Jun-hong
authors.initials: JH
authors.lastname: Li
authors.forename: Zhen-yu
authors.initials: ZY
authors.lastname: Li
authors.forename: Wei-gang
authors.initials: WG
authors.lastname: Cheng
authors.forename: Meng-lin
authors.initials: ML
authors.lastname: Jin
authors.forename: Liang
authors.initials: L
authors.lastname: He
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000473:pathology; D005260:Female; D051417:Focal Adhesion Kinase 1 / Q000378:metabolism*; D020690:GTPase-Activating Proteins / Q000378:metabolism*; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D010766:Phosphorylation; D011379:Prognosis; D011980:Receptors, Progesterone / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
chemical_list: C112352:DLC1 protein, human; D020690:GTPase-Activating Proteins; D011980:Receptors, Progesterone; D025521:Tumor Suppressor Proteins; D051417:Focal Adhesion Kinase 1; C496050:PTK2 protein, human