title: Thioredoxin 1 overexpression extends mainly the earlier part of life span in mice.
abstract: We examined the effects of increased levels of thioredoxin 1 (Trx1) on resistance to oxidative stress and aging in transgenic mice overexpressing Trx1 [Tg(TRX1)(+/0)]. The Tg(TRX1)(+/0) mice showed significantly higher Trx1 protein levels in all the tissues examined compared with the wild-type littermates. Oxidative damage to proteins and levels of lipid peroxidation were significantly lower in the livers of Tg(TRX1)(+/0) mice compared with wild-type littermates. The survival study demonstrated that male Tg(TRX1)(+/0) mice significantly extended the earlier part of life span compared with wild-type littermates, but no significant life extension was observed in females. Neither male nor female Tg(TRX1)(+/0) mice showed changes in maximum life span. Our findings suggested that the increased levels of Trx1 in the Tg(TRX1)(+/0) mice were correlated to increased resistance to oxidative stress, which could be beneficial in the earlier part of life span but not the maximum life span in the C57BL/6 mice.
authors.affiliation: Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, TX 78245-3207, USA.
authors.forename: Viviana I
authors.initials: VI
authors.lastname: Pérez
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Cortez
authors.forename: Christie M
authors.initials: CM
authors.lastname: Lew
authors.forename: Marisela
authors.initials: M
authors.lastname: Rodriguez
authors.forename: Celeste R
authors.initials: CR
authors.lastname: Webb
authors.forename: Holly
authors.initials: H
authors.lastname: Van Remmen
authors.forename: Asish
authors.initials: A
authors.lastname: Chaudhuri
authors.forename: Wenbo
authors.initials: W
authors.lastname: Qi
authors.forename: Shuko
authors.initials: S
authors.lastname: Lee
authors.forename: Alex
authors.initials: A
authors.lastname: Bokov
authors.forename: Wilson
authors.initials: W
authors.lastname: Fok
authors.forename: Dean
authors.initials: D
authors.lastname: Jones
authors.forename: Arlan
authors.initials: A
authors.lastname: Richardson
authors.forename: Junji
authors.initials: J
authors.lastname: Yodoi
authors.forename: Yiqiang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Kaoru
authors.initials: K
authors.lastname: Tominaga
authors.forename: Gene B
authors.initials: GB
authors.lastname: Hubbard
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ikeno
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000375:Aging / Q000235:genetics / Q000473:pathology / Q000502:physiology; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000378:metabolism; D004178:Diquat / Q000633:toxicity; D005260:Female; D054477:Glutaredoxins / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism; D008136:Longevity / Q000235:genetics* / Q000502:physiology*; D048848:MAP Kinase Kinase Kinase 5 / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D008954:Models, Biological; D016328:NF-kappa B / Q000235:genetics; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D012727:Sex Characteristics; D013879:Thioredoxins / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D015854:Up-Regulation
chemical_list: D000975:Antioxidants; C516006:Glrx protein, mouse; D054477:Glutaredoxins; D016328:NF-kappa B; C515559:Txn1 protein, mouse; C516112:Txn2 protein, mouse; D013879:Thioredoxins; D000080242:8-Hydroxy-2'-Deoxyguanosine; D004178:Diquat; D048848:MAP Kinase Kinase Kinase 5; C482859:Map3k5 protein, mouse; D003849:Deoxyguanosine; D005978:Glutathione