title: Is the treatment of CIN 2 always necessary in women under 25 years old?
abstract: OBJECTIVE
  The purpose of this study was to review the outcome of conservatively managed cervical intraepithelial neoplasia (CIN) 2 in women <25 years old.
  
  
  METHODS
  This was a retrospective review that included women who were <25 years old with biopsy proven CIN2 between 2005 and 2009. Analysis was performed that compared women who had immediate treatment with women whose treatment was deferred >4 months. The primary outcome measure was spontaneous regression of CIN2. Secondary outcomes were treatment rates and loss to follow-up evaluation.
  
  
  RESULTS
  Of the 452 women who were identified, 256 women (57%) received immediate treatment; 157 women (35%) met the definition for conservative management, and 39 women (9%) had unknown subsequent management. Of the 157 women who were managed conservatively, 98 women (62%) showed spontaneous regression, with a median of 8 months observation. No conservatively managed women progressed to cancer.
  
  
  CONCLUSIONS
  Based on the 62% regression rate in this study, routine treatment may not be necessary for all women with CIN2 who are <25 years old.
authors.affiliation: Department of Obstetrics and Gynecology, Christchurch School of Medicine, University of Otago, Christchurch, New Zealand. mcabr965@student.otago.ac.nz
authors.forename: Bree
authors.initials: B
authors.lastname: McAllum
authors.forename: Peter H H
authors.initials: PH
authors.lastname: Sykes
authors.forename: Lynn
authors.initials: L
authors.lastname: Sadler
authors.forename: Helene
authors.initials: H
authors.lastname: Macnab
authors.forename: Bryony J
authors.initials: BJ
authors.lastname: Simcock
authors.forename: Adel K
authors.initials: AK
authors.lastname: Mekhail
mesh_terms: D000328:Adult; D000367:Age Factors; D003127:Colposcopy; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D012189:Retrospective Studies; D002578:Uterine Cervical Dysplasia / Q000473:pathology / Q000628:therapy*; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000628:therapy*; D014626:Vaginal Smears; D055815:Young Adult