title: Assessment of rewarding and reinforcing properties of biperiden in conditioned place preference in rats.
abstract: Biperiden is one of the most commonly abused anticholinergic drugs. This study assessed its motivational effects in the acquisition of conditioned place preference in rats. Biperiden neither produced place conditioning itself nor enhanced the rewarding effect of morphine. Furthermore, biperiden in combination with haloperidol also did not affect place preference. These findings suggest that biperiden seems devoid of abuse potential properties at least at the doses used.
authors.affiliation: Department of Pharmacology and Clinical Pharmacology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Oruc
authors.initials: O
authors.lastname: Allahverdiyev
authors.forename: Asiye
authors.initials: A
authors.lastname: Nurten
authors.forename: Nurhan
authors.initials: N
authors.lastname: Enginar
mesh_terms: D000818:Animals; D001712:Biperiden / Q000494:pharmacology*; D002755:Choice Behavior / Q000187:drug effects*; D003213:Conditioning, Psychological / Q000187:drug effects*; D004347:Drug Interactions; D058999:Drug-Seeking Behavior / Q000187:drug effects*; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D009020:Morphine / Q000494:pharmacology; D018727:Muscarinic Antagonists / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012054:Reinforcement, Psychology; D012201:Reward
chemical_list: D018727:Muscarinic Antagonists; D001712:Biperiden; D009020:Morphine; D006220:Haloperidol