title: Elevated adenosine deaminase activity in overweight and obese Indian subjects.
abstract: OBJECTIVE
  To determine adenosine deaminase activity in overweight and obese Indian subjects.
  
  
  METHODS
  This study comprised of 100 subjects. The body mass index (BMI) of subjects was calculated and adenosine deaminase activity was determined in their fasting blood sample. The study was divided into three groups depending upon BMI: Control (n = 40, BMI < 25 kg/m(2)), Overweight (n = 30, BMI 25-29.9 kg/m(2)) and Obese (n = 30, BMI ≥ 30 kg/m(2)).
  
  
  RESULTS
  The serum adenosine deaminase activity was significantly increased in overweight and obese subjects and as well as in combined overweight and obese group as compared to control (P < 0.0001).
  
  
  CONCLUSIONS
  Adenosine, an endogenous anti-inflammatory metabolite, is increased in response to inflammation produced by adipose tissue in obesity. However, adenosine deaminase acts on adenosine to convert it into inosine, thereby increasing adenosine deaminase activity in overweight and obese Indian subjects.
authors.affiliation: Department of Biochemistry, People's College of Medical Sciences and Research Center, Bhopal, Madhya Pradesh, India. drjadhavaa@yahoo.co.in
authors.forename: Ashish Anantrao
authors.initials: AA
authors.lastname: Jadhav
authors.forename: Anuradha
authors.initials: A
authors.lastname: Jain
mesh_terms: D000241:Adenosine / Q000097:blood*; D000243:Adenosine Deaminase / Q000097:blood*; D000273:Adipose Tissue / Q000378:metabolism / Q000503:physiopathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D001823:Body Composition; D015992:Body Mass Index; D005215:Fasting; D005260:Female; D006801:Humans; D007194:India; D007288:Inosine / Q000097:blood*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000201:enzymology* / Q000503:physiopathology
chemical_list: D007288:Inosine; D000243:Adenosine Deaminase; D000241:Adenosine