title: Antibacterial activity of Capsicum annuum extract and synthetic capsaicinoid derivatives against Streptococcus mutans.
abstract: The inhibitory effects of the ethyl acetate extract and capsaicin (1) and dihydrocapsaicin (2) isolated from fruits of Capsicum annuum chili pepper type, and synthetic capsaicinoid derivatives (N-(4-hydroxyphenylethyl)decamide (3), (E)-N-(4-hydroxy-3-methoxybenzyl)-3,7-dimethylocta- 2,6-dienamide (4), 4-hydroxy-3-methoxy-N-((E)-3, 7-dimethylocta-2,6-dienyl)benzamide (5) andN-(4-hydroxy- 3-methoxybenzyl)decamide (6) at different concentrations were evaluated against Streptococcus mutans. The minimum inhibitory concentration at which the ethyl acetate extract prevented the growth of S. mutans was 2.5 mg/mL; those of the isolated compounds 1 and 2 were 1.25 μg/mL, while 3 was 5.0 μg/mL, and 4, 5 and 6 were 2.5 μg/mL, respectively.
authors.affiliation: Laboratório de Tecnologia de Alimentos, UENF, Campos dos Goytacazes, Rio de Janeiro, RJ 28013-602, Brazil.
authors.forename: Moema Mocaiber Peralva
authors.initials: MM
authors.lastname: Santos
authors.forename: Olney
authors.initials: O
authors.lastname: Vieira-da-Motta
authors.forename: Ivo José Curcino
authors.initials: IJ
authors.lastname: Vieira
authors.forename: Raimundo
authors.initials: R
authors.lastname: Braz-Filho
authors.forename: Paula Santos
authors.initials: PS
authors.lastname: Gonçalves
authors.forename: Edmilsom José
authors.initials: EJ
authors.lastname: Maria
authors.forename: Wagner Silva
authors.initials: WS
authors.lastname: Terra
authors.forename: Rosana
authors.initials: R
authors.lastname: Rodrigues
authors.forename: Claudio Luiz Melo
authors.initials: CL
authors.lastname: Souza
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002211:Capsaicin / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D002212:Capsicum / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D013295:Streptococcus mutans / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D002211:Capsaicin; C012906:dihydrocapsaicin