title: Synthesis of 2,4,6-trisubstituted pyridines via an olefin cross-metathesis/Heck-cyclisation-elimination sequence.
abstract: Heck reactions were performed on α,β-unsaturated-δ-sulfonamido intermediates, derived from cross metathesis, to allow the instalment of substituents at the β position. Subsequent one-pot cyclisation/elimination provides an operationally simple, catalytic and convergent synthesis of 2,4,6-trisubstituted pyridines.
authors.affiliation: Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK. timothy.donohoe@chem.ox.ac.uk
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Donohoe
authors.forename: John F
authors.initials: JF
authors.lastname: Bower
authors.forename: David B
authors.initials: DB
authors.lastname: Baker
authors.forename: José A
authors.initials: JA
authors.lastname: Basutto
authors.forename: Louis K M
authors.initials: LK
authors.lastname: Chan
authors.forename: Peter
authors.initials: P
authors.lastname: Gallagher
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry*; D028561:Transition Elements / Q000737:chemistry
chemical_list: D000475:Alkenes; D011725:Pyridines; D028561:Transition Elements