title: Design and synthesis of C35-fluorinated solamins and their growth inhibitory activities against human cancer cell lines.
abstract: The convergent synthesis of C35-fluorinated analogues of solamin, a mono-THF Annonaceous acetogenin, has been achieved by the Sonogashira coupling of the THF ring fragment and the fluorinated γ-lactone fragment. It was revealed that the number of fluorine atoms on the γ-lactone moiety affects the growth inhibitory activities against human cancer cell lines.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. kojima@phs.osaka-u.ac.jp
authors.forename: Naoto
authors.initials: N
authors.lastname: Kojima
authors.forename: Yuki
authors.initials: Y
authors.lastname: Suga
authors.forename: Hiromi
authors.initials: H
authors.lastname: Hayashi
authors.forename: Takao
authors.initials: T
authors.lastname: Yamori
authors.forename: Takehiko
authors.initials: T
authors.lastname: Yoshimitsu
authors.forename: Tetsuaki
authors.initials: T
authors.lastname: Tanaka
mesh_terms: D054378:Acetogenins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006131:Growth Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D054879:Halogenation; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D054378:Acetogenins; D000970:Antineoplastic Agents; D006131:Growth Inhibitors