title: [Changes of doxorubicin distribution in blood and plasma after its inclusion into nanophospholipd formulation].
abstract: The drug composition based on the plant phospholipids and the antitumor drug doxorubicin (particle size <30 nm) was obtained using original technology elaborated in the Institute of Biomedical Chemistry (Russian Academy of Medical Sciences). In in vitro experiments demonstrated decreased drug association with blood cells for this nanophospholipid form as compared with free doxorubicin. This was accompanied by a with corresponding increase in its plasma level ans also by drug redistribution from plasma protein fraction to high density lipoproteins. Significance of these changes for doxorubicin biodistributon and antitumor activity is discussed.
authors.forename: M A
authors.initials: MA
authors.lastname: Zyova
authors.forename: O M
authors.initials: OM
authors.lastname: Ipatova
authors.forename: V N
authors.initials: VN
authors.lastname: Prozorovskiĭ
authors.forename: N V
authors.initials: NV
authors.lastname: Medvedeva
authors.forename: A A
authors.initials: AA
authors.lastname: Voskresenskaia
authors.forename: T S
authors.initials: TS
authors.lastname: Zakharova
authors.forename: T I
authors.initials: TI
authors.lastname: Torkhovskaia
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology; D004317:Doxorubicin / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology; D004912:Erythrocytes / Q000378:metabolism; D008075:Lipoproteins, HDL / Q000378:metabolism; D008297:Male; D053758:Nanoparticles; D010743:Phospholipids / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000903:Antibiotics, Antineoplastic; D008075:Lipoproteins, HDL; D010743:Phospholipids; D004317:Doxorubicin