title: Development and prevention of morphologic and ultrastructural changes in uremia-induced hyperplastic parathyroid gland.
abstract: The detailed ultrastructural changes of uremia-induced hyperplastic parathyroid gland and the effects of current medical treatments for secondary hyperparathyroidism were investigated. Marked enlargement of parathyroid cell with accumulation of mitochondria and lipids and a significant increase in the thickness of the pericapillary area with increased fibrosis and appearance of fibroblast like cells were noted in the hyperplastic gland caused by uremia and phosphate retention. These ultrastructural changes and biochemical findings indicating hyperparathyroidism were significantly suppressed by all of the treatment using phosphate restriction, calcitriol, and cinacalcet. The characteristic ultrastructural changes, including the morphologic evidence of nodule formation, were indicated.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan. shiizaki@jichi.ac.jp
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Shiizaki
authors.forename: Ikuji
authors.initials: I
authors.lastname: Hatamura
authors.forename: Masao
authors.initials: M
authors.lastname: Mato
authors.forename: Eiko
authors.initials: E
authors.lastname: Nakazawa
authors.forename: Fumie
authors.initials: F
authors.lastname: Saji
authors.forename: Akira
authors.initials: A
authors.lastname: Onishi
authors.forename: Manabu
authors.initials: M
authors.lastname: Ogura
authors.forename: Yuko
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Eiji
authors.initials: E
authors.lastname: Kusano
mesh_terms: D000818:Animals; D002117:Calcitriol / Q000494:pharmacology; D002196:Capillaries / Q000648:ultrastructure; D000069449:Cinacalcet; D004195:Disease Models, Animal; D006962:Hyperparathyroidism, Secondary / Q000150:complications / Q000473:pathology* / Q000517:prevention & control; D006965:Hyperplasia; D008297:Male; D009281:Naphthalenes / Q000494:pharmacology; D009392:Nephrectomy; D015388:Organelles / Q000648:ultrastructure; D010280:Parathyroid Glands / Q000098:blood supply / Q000473:pathology* / Q000648:ultrastructure; D010758:Phosphorus / Q000172:deficiency; D016226:Phosphorus, Dietary / Q000008:administration & dosage; D051381:Rats; D017207:Rats, Sprague-Dawley; D014511:Uremia / Q000150:complications / Q000473:pathology* / Q000628:therapy
chemical_list: D009281:Naphthalenes; D016226:Phosphorus, Dietary; D010758:Phosphorus; D002117:Calcitriol; D000069449:Cinacalcet