title: Isolated compounds from Sorghum bicolor L. inhibit the classical pathway of the complement.
abstract: The present study evaluated the anticomplement effects from isolated compounds of Sorghum bicolor in classical pathway complement system. Using column chromatograph, three compounds; Sorgoleone-362 (1), Sorgoleone-360 (2) and Sorgoleone-386 (3) were isolated and evaluated for in vitro anticomplement activity. Sorgoleone-386 showed inhibitory activity against complement system with 50% inhibitory concentrations (IC(50)) values of 148.3μg/ml. This is the first report of anticomplement activity of isolated compounds from Sorghum bicolor.
authors.affiliation: Department of Medicinal Biotechnology, College of Natural Resources and Life Science, Dong-A University, Busan 604-714, South Korea.
authors.forename: Hyung-In
authors.initials: HI
authors.lastname: Moon
authors.forename: Young-Choon
authors.initials: YC
authors.lastname: Lee
authors.forename: Jai-Heon
authors.initials: JH
authors.lastname: Lee
mesh_terms: D000818:Animals; D016227:Benzoquinones / Q000302:isolation & purification / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D002934:Cinnamates / Q000494:pharmacology; D051056:Complement Inactivating Agents / Q000302:isolation & purification / Q000494:pharmacology*; D003171:Complement Pathway, Classical / Q000187:drug effects*; D053630:Depsides / Q000494:pharmacology; D005419:Flavonoids / Q000494:pharmacology; D006461:Hemolysis / Q000276:immunology; D020128:Inhibitory Concentration 50; D008055:Lipids / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D011817:Rabbits; D012756:Sheep; D045868:Sorghum / Q000737:chemistry*; D000097123:Rosmarinic Acid
chemical_list: D016227:Benzoquinones; D002934:Cinnamates; D051056:Complement Inactivating Agents; D053630:Depsides; D005419:Flavonoids; D008055:Lipids; D010936:Plant Extracts; D000097123:Rosmarinic Acid; C113738:sorgoleone; C052083:tiliroside