title: Magnetic field anisotropy based MR tractography.
abstract: Non-invasive measurements of structural orientation provide unique information regarding the connectivity and functionality of fiber materials. In the present study, we use a capillary model to demonstrate that the direction of fiber structure can be obtained from susceptibility-induced magnetic field anisotropy. The interference pattern between internal and external magnetic field gradients carries the signature of the underlying anisotropic structure and can be measured by MRI-based water diffusion measurements. Through both numerical simulation and experiments, we found that this technique can determine the capillary orientation within 3°. Therefore, susceptibility-induced magnetic field anisotropy may be useful for an alternative tractography method when diffusion anisotropy is small at higher magnetic field strength without the need to rotate the subject inside the scanner.
authors.affiliation: School of Nano-BioScience and Chemical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea.
authors.forename: S H
authors.initials: SH
authors.lastname: Han
authors.forename: Y K
authors.initials: YK
authors.lastname: Song
authors.forename: F H
authors.initials: FH
authors.lastname: Cho
authors.forename: S
authors.initials: S
authors.lastname: Ryu
authors.forename: G
authors.initials: G
authors.lastname: Cho
authors.forename: Y-Q
authors.initials: YQ
authors.lastname: Song
authors.forename: H
authors.initials: H
authors.lastname: Cho
mesh_terms: D000465:Algorithms; D016880:Anisotropy; D001921:Brain; D002196:Capillaries / Q000033:anatomy & histology; D003198:Computer Simulation; D056324:Diffusion Tensor Imaging / Q000379:methods*; D004574:Electromagnetic Fields; D007091:Image Processing, Computer-Assisted; D014867:Water / Q000737:chemistry
chemical_list: D014867:Water