title: Roles of planar cell polarity pathways in the development of neural [correction of neutral] tube defects.
abstract: Neural tube defects (NTDs) are the second most common birth defect in humans. Despite many advances in the understanding of NTDs and the identification of many genes related to NTDs, the fundamental etiology for the majority of cases of NTDs remains unclear. Planar cell polarity (PCP) signaling pathway, which is important for polarized cell movement (such as cell migration) and organ morphogenesis through the activation of cytoskeletal pathways, has been shown to play multiple roles during neural tube closure. The disrupted function of PCP pathway is connected with some NTDs. Here, we summarize our current understanding of how PCP factors affect the pathogenesis of NTDs.
authors.affiliation: Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wu
authors.forename: Xupei
authors.initials: X
authors.lastname: Huang
authors.forename: Yimin
authors.initials: Y
authors.lastname: Hua
authors.forename: Dezhi
authors.initials: D
authors.lastname: Mu
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism; D015820:Cadherins / Q000235:genetics / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D016764:Cell Polarity / Q000235:genetics / Q000502:physiology*; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000378:metabolism; D000072261:Dishevelled Proteins; D051157:Frizzled Receptors / Q000235:genetics / Q000378:metabolism; D006801:Humans; D060588:LIM Domain Proteins / Q000235:genetics / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D009436:Neural Tube Defects / Q000196:embryology* / Q000209:etiology*; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D013045:Species Specificity; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism; D051153:Wnt Proteins / Q000378:metabolism
chemical_list: C464902:ANKRD6 protein, human; D048868:Adaptor Proteins, Signal Transducing; C454220:CELSR1 cadherin, human; D015820:Cadherins; D002352:Carrier Proteins; D003598:Cytoskeletal Proteins; D000072261:Dishevelled Proteins; D051157:Frizzled Receptors; D060588:LIM Domain Proteins; D008565:Membrane Proteins; C515173:PRICKLE1 protein, human; D010750:Phosphoproteins; D025521:Tumor Suppressor Proteins; C488287:VANGL1 protein, human; D051153:Wnt Proteins