title: [Determination of pindone in agricultural products by LC-MS/MS].
abstract: A sensitive and selective analytical method for the determination of pindone in agricultural products by LC-MS/MS was developed. Pindone was extracted with acetone, and an aliquot of the crude extract was re-extracted with hexane. For lipid-rich samples, the crude extract was further cleaned up by acetonitrile-hexane partitioning. The extract was cleaned up on a tandem graphitized carbon-silica gel column. For brown rice, soybean, and tea, PSA column cleanup was added prior to LC-MS/MS determination. Average recoveries of pindone from brown rice, soybean, potato, spinach, cabbage, apple, orange, tomato, cucumber, and tea fortified at 0.001 mg/kg were 81-93%, and the relative standard deviations were 2-7%. The limit of quantitation (S/N ≥ 10) of the developed method was 0.001 mg/kg for all the tested agricultural products.
authors.affiliation: National Institute of Health Sciences, Tokyo. shizsaito@nihs.go.jp
authors.forename: Shizuka
authors.initials: S
authors.lastname: Saito
authors.forename: Satoru
authors.initials: S
authors.lastname: Nemoto
authors.forename: Rieko
authors.initials: R
authors.lastname: Matsuda
mesh_terms: D002853:Chromatography, Liquid / Q000379:methods*; D018556:Crops, Agricultural / Q000737:chemistry*; D007189:Indans / Q000032:analysis*; D012378:Rodenticides / Q000032:analysis*; D053719:Tandem Mass Spectrometry / Q000379:methods*
chemical_list: D007189:Indans; D012378:Rodenticides; C014152:pindone