title: Urinary monocyte chemoattractant protein-1 in renal disease.
abstract: Monocyte chemoattractant protein-1 (MCP-1/CCL2) has a critical role in the development of various renal diseases. Data from disease specific experimental animal models and clinical studies confirm that MCP-1 plays an important part in the pathogenesis of renal diseases. The action of MCP-1 in these studies has been shown to be more complex than the traditional concept of monocyte/macrophage recruitment to the inflammatory site. MCP-1 is expressed in renal tissues and it is detectable in urine of patients with a variety of renal diseases. Measurement of urinary levels of MCP-1 can provide valuable information not only for the diagnosis of active renal disease, but also for monitoring of response to therapy. Urinary MCP-1 measurement can provide help with evaluation of the prognosis in various renal diseases. Furthermore, selective targeting of MCP-1 could be an effective treatment in suppressing a number of renal diseases as blocking MCP-1 has already been shown to ameliorate renal diseases in experimental animal models. The advantage of measuring urinary MCP-1 rather than the conventional markers must now be validated using a larger cohort of patients in different renal diseases. Also the therapeutic potential of MCP-1 targeting agents needs to be investigated in clinical studies.
authors.affiliation: Imperial College Kidney and Transplant Institute, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom.
authors.forename: Min Jeong
authors.initials: MJ
authors.lastname: Kim
authors.forename: Frederick W K
authors.initials: FW
authors.lastname: Tam
mesh_terms: D000818:Animals; D018932:Chemokine CCL2 / Q000502:physiology / Q000652:urine*; D006801:Humans; D007674:Kidney Diseases / Q000652:urine*
chemical_list: D018932:Chemokine CCL2