title: Role of exogenously supplied ferulic and p-coumaric acids in mimicking the mode of action of acetolactate synthase inhibiting herbicides.
abstract: Chlorsulfuron and imazethapyr (herbicides that inhibit acetolactate synthase; ALS, EC 4.1.3.18) produced a strong accumulation of hydroxycinnamic acids that was related to the induction of the first enzyme of the shikimate pathway, 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase (EC 2.5.2.54). The exogenous application of two hydroxycinnamic acids, ferulic and p-coumaric acids, to pea plants resulted in their internal accumulation, arrested growth, carbohydrate and quinate accumulation in the leaves, and the induction of ethanolic fermentation. These effects resemble some of the physiological effects detected after acetolactate synthase inhibition and suggest important roles for ferulic and p-coumaric acids in the mode of action of herbicides inhibiting the biosynthesis of branched chain amino acids.
authors.affiliation: Departamento de Ciencias del Medio Natural, Universidad Pública de Navarra, Campus Arrosadia, E-31006 Pamplona, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Orcaray
authors.forename: María
authors.initials: M
authors.lastname: Igal
authors.forename: Ana
authors.initials: A
authors.lastname: Zabalza
authors.forename: Mercedes
authors.initials: M
authors.lastname: Royuela
mesh_terms: D000095:Acetolactate Synthase / Q000037:antagonists & inhibitors*; D000597:Amino Acids, Branched-Chain / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D003373:Coumaric Acids / Q000032:analysis / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006540:Herbicides / Q000494:pharmacology*; D018532:Pisum sativum / Q000187:drug effects; D018515:Plant Leaves / Q000187:drug effects / Q000378:metabolism; D011422:Propionates
chemical_list: D000597:Amino Acids, Branched-Chain; D003373:Coumaric Acids; D004791:Enzyme Inhibitors; D006540:Herbicides; D011422:Propionates; C004999:ferulic acid; D000095:Acetolactate Synthase; C495469:p-coumaric acid