title: Prevalence of etravirine-associated mutations in clinical samples with genotypic resistance to nevirapine and efavirenz in Brazilian clinics.
abstract: Nonnucleoside reverse transcriptase inhibitors (NNRTIs) are potent and well tolerated. In Brazil, the first-generation NNRTI efavirenz is included in the majority of first-line antiretroviral treatment regimens. In this study, we evaluated the effectiveness of etravirine, a new second-generation NNRTI, among patients failing antiretroviral regimens containing first-generation NNRTIs. We assessed single resistance mutations to etravirine as well as complex resistance mutations profile and discuss the potential of introducing etravirine as salvage therapy.
authors.affiliation: Laboratório de Virologia Molecular, Department of Genetics, Federal University of Rio de Janeiro, Rio de Janiero, Brazil.
authors.forename: Angelica N
authors.initials: AN
authors.lastname: Martins
authors.forename: Monica B
authors.initials: MB
authors.lastname: Arruda
authors.forename: Agdemir W
authors.initials: AW
authors.lastname: Aleixo
authors.forename: Ana F
authors.initials: AF
authors.lastname: Pires
authors.forename: Dirceu B
authors.initials: DB
authors.lastname: Greco
authors.forename: Rodrigo
authors.initials: R
authors.lastname: de M Brindeiro
authors.forename: Amilcar
authors.initials: A
authors.lastname: Tanuri
mesh_terms: D000480:Alkynes; D019380:Anti-HIV Agents / Q000494:pharmacology*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D048588:Benzoxazines / Q000494:pharmacology*; D001938:Brazil; D003521:Cyclopropanes; D024882:Drug Resistance, Viral; D006678:HIV / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D006801:Humans; D020125:Mutation, Missense; D019829:Nevirapine / Q000494:pharmacology*; D009570:Nitriles; D015995:Prevalence; D011724:Pyridazines / Q000494:pharmacology*; D011743:Pyrimidines
chemical_list: D000480:Alkynes; D019380:Anti-HIV Agents; D048588:Benzoxazines; D003521:Cyclopropanes; D009570:Nitriles; D011724:Pyridazines; D011743:Pyrimidines; C451734:etravirine; D019829:Nevirapine; C098320:efavirenz