title: Histomorphometric evaluation of calcium phosphate bone grafts on bone repair.
abstract: Because of its biocompatibility and osteoconductive properties, calcium-phosphate cement has been used as bone surrogate.
  
  
  OBJECTIVE
  The purpose of this study was to do a histomorphometric comparison of bone regeneration using hydroxyapatite biphasic ceramic, calcium-phosphate cement and autogenous bone graft.
  
  
  METHODS
  Prospective and laboratorial experiment.
  
  
  METHODS
  Two 5mm in diameter cavities (left and right--test and control) were made in the parietal bone of 72 rats. The GI, GII, GIII and GIV test cavities were filled with calcium-phosphate cement, biphasic ceramic hydroxyapatite, autogenous bone graft and blood. The animals were killed at 30, 60 and 90 days and the specimens underwent histomorphometric analysis.
  
  
  RESULTS
  The results showed that autogenous bone graft treated defects had significantly more new bone at 30 days compared to other test groups. Within 60 and 90 days, bone formation was more significant in the test groups GI, GII and GIII; GI and GII encompassed larger areas. Throughout the evaluation periods, GII tests showed more bone formation when compared to GI.
  
  
  CONCLUSIONS
  Biomaterials depicted a significantly increase in bone content, when compared to autogenous bone graft, concerning bone regeneration.
authors.affiliation: MSc in Dentistry - PUCRS; Graduate Student in Dentistry - University of Pernambuco in Maxillofacial Surgery and Traumatology, PhD. FOP/UPE; Assistant Professor of the Health and Education Center - Federal University of Grande - CES/UFCG. Electronic address: karisguimaraes@yahoo.com.br.
authors.forename: Karis Barbosa
authors.initials: KB
authors.lastname: Guimarães
authors.affiliation: PhD; Adjunct Professor and Coordinator - Graduate Program in Dentistry - University of Pernambuco. Maxillofacial surgery and Traumatology - FOP/UPE.
authors.forename: Belmiro Cavalcanti
authors.initials: BC
authors.lastname: do Egito Vasconcelos
authors.affiliation: PhD. Adjunct Professor of the Graduate Program in Dentistry - Federal University of Paraíba - Oral Diagnosis - UFPB.
authors.forename: Francisco
authors.initials: F
authors.lastname: de Assis Limeira Júnior
authors.affiliation: PhD. Adjunct Professor of the Graduate Program in Dentistry - Federal University of Paraíba - Oral Diagnosis - UFPB.
authors.forename: Frederico Barbosa
authors.initials: FB
authors.lastname: de Sousa
authors.affiliation: PhD; Adjunct Professor of the Graduate Program in Dentistry - University of Pernambuco, in Maxillofacial Surgery and Trauma - FOP/UPE.
authors.forename: Emanuel Sávio
authors.initials: ES
authors.lastname: de Souza Andrade
authors.affiliation: PhD; Adjunct Professor of the Graduate Program in Dentistry - University of Pernambuco, in Maxillofacial Surgery and Trauma - FOP/UPE. Electronic address: ricardoholanda@bol.com.br.
authors.forename: Ricardo José
authors.initials: RJ
authors.lastname: de Holanda Vasconcellos
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D001843:Bone Cements / Q000627:therapeutic use*; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation; D002130:Calcium Phosphates / Q000627:therapeutic use*; D002516:Ceramics / Q000627:therapeutic use; D017886:Durapatite / Q000627:therapeutic use*; D008297:Male; D010294:Parietal Bone / Q000601:surgery; D011446:Prospective Studies; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D018786:Bone Substitutes; D002130:Calcium Phosphates; D017886:Durapatite; C020243:calcium phosphate