title: Mesothelioma of tunica vaginalis of "uncertain malignant potential" - an evolving concept: case report and review of the literature.
abstract: Mesothelioma of tunica vaginalis is a rare neoplasm, typically demonstrating frankly malignant morphology and aggressive behavior. Rare cases of well-differentiated papillary mesotheliomas have also been reported, which, in contrast, demonstrate indolent behavior. There are, however, cases which do not fit into the well-differentiated or diffuse malignant mesothelioma categories and can be considered mesothelioma of tunica vaginalis of "uncertain malignant potential", which is an emerging diagnostic category. A 57-year-old man presented with a neoplasm in a hydrocele sac. The neoplasm was non-invasive, but showed focal complex and solid growth and it was difficult to categorize either as well-differentiated papillary mesotheliomas or malignant mesothelioma. After the initial limited resection, the patient underwent radical orchiectomy with hemiscrotectomy and is alive and without disease progression after 6 years. Documentation of these rare tumors will allow their distinction from true malignant mesotheliomas and will facilitate the development of specific treatment recommendations.
authors.affiliation: Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Rockyview General Hospital, 7007 14 st, Calgary, T2V 1P9, Alberta, Canada. kiril.trpkov@cls.ab.ca
authors.forename: Kiril
authors.initials: K
authors.lastname: Trpkov
authors.forename: Richard
authors.initials: R
authors.lastname: Barr
authors.forename: Andrew
authors.initials: A
authors.lastname: Kulaga
authors.forename: Asli
authors.initials: A
authors.lastname: Yilmaz
mesh_terms: D001706:Biopsy; D002454:Cell Differentiation; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008654:Mesothelioma / Q000145:classification / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009919:Orchiectomy; D009626:Terminology as Topic; D006848:Testicular Hydrocele / Q000473:pathology* / Q000601:surgery; D013736:Testicular Neoplasms / Q000145:classification / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome