title: Tissue distribution of Dechlorane Plus and its dechlorinated analogs in contaminated fish: high affinity to the brain for anti-DP.
abstract: Information on tissue distribution of Dechlorane Plus (DP) and its dechlorinated analogs in wildlife is scarce. DP isomers and two dechlorinated compounds, anti-Cl(11)-DP and anti-Cl(10)-DP, were examined in the muscle, liver, and brain tissues of two bottom fish species collected from an electronic waste recycling site, South China. The median levels of syn-, anti-, and anti-Cl(11)-DP isomers in the tissues ranged 0.18-39.1, 0.22-52.9, and 0.01-5.63 ng/g wet wt, respectively. Anti-Cl(10)-DP was only detected in one muscle sample of mud carp (0.01 ng/g wet wt), although it was consistently detected in the sediments (0.42-0.83 ng/g dry wt). Preferential distribution in liver relative to muscle was observed for syn-DP and anti-Cl(11)-DP. However, a high persistent retention in the brain compared to the liver was observed for anti-DP, suggesting that this isomer can across the blood-brain barrier of fish, and may cause adverse effects to the nervous system in the exposed biota.
authors.affiliation: State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jiang-Ping
authors.initials: JP
authors.lastname: Wu
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Luo
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: She-Jun
authors.initials: SJ
authors.lastname: Chen
authors.forename: Bi-Xian
authors.initials: BX
authors.lastname: Mai
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D001923:Brain Chemistry; D005399:Fishes / Q000378:metabolism*; D005506:Food Contamination / Q000032:analysis*; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry / Q000493:pharmacokinetics*; D007536:Isomerism; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D015394:Molecular Structure; D009132:Muscles / Q000737:chemistry / Q000378:metabolism; D009928:Organ Specificity; D011083:Polycyclic Compounds / Q000737:chemistry / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D006843:Hydrocarbons, Chlorinated; D011083:Polycyclic Compounds; C526360:dechlorane plus