title: Induction the cornification of squamous cancerous cells to eliminate tumor cells by promotion cell differentiation and stratum.
abstract: Cornification is a kind of apoptosis of squamous epithelial cell in the upper layer of the epithelial tissue. The basal cells away from cell-cycle embark on terminal differentiation, stratum, then die by apoptosis. The critical elements interference from the normal differentiation of squamous cells will lead to cell malignant transformation. We would like to put forward a hypothesis that initiation the cornification of squamous cancerous cells by promotion cell differentiation and stratum can promote squamous carcinoma cells death. Attempts of induction squamous cancerous cells terminal differentiation will add to our understanding of the connection between keratinocytes cornification and the death of squamous-cell carcinoma.
authors.affiliation: Department of Gynecology and Obstetrics, Qilu Hospital Affiliated to Shandong University, Shandong 250012, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhou
authors.forename: Yong
authors.initials: Y
authors.lastname: Cheng
authors.forename: Dingqing
authors.initials: D
authors.lastname: Feng
authors.forename: Bin
authors.initials: B
authors.lastname: Ling
authors.forename: Peishu
authors.initials: P
authors.lastname: Liu
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002454:Cell Differentiation; D006801:Humans