title: Functional modulation of the metastatic suppressor Nm23-H1 by oncogenic viruses.
abstract: Evidence over the last two decades from a number of disciplines has solidified some fundamental concepts in metastasis, a major contributor to cancer associated deaths. However, significant advances have been made in controlling this critical cellular process by focusing on targeted therapy. A key set of factors associated with this invasive phenotype is the nm23 family of over twenty metastasis-associated genes. Among the eight known isoforms, Nm23-H1 is the most studied potential anti-metastatic factor associated with human cancers. Importantly, a growing body of work has clearly suggested a critical role for Nm23-H1 in limiting tumor cell motility and progression induced by several tumor viruses, including Epstein-Barr virus (EBV), Kaposi's sarcoma associated herpes virus (KSHV) and human papilloma virus (HPV). A more in depth understanding of the interactions between tumor viruses encoded antigens and Nm23-H1 will facilitate the elucidation of underlying mechanism(s) which contribute to virus-associated cancers. Here, we review recent studies to explore the molecular links between human oncogenic viruses and progression of metastasis, in particular the deregulation of Nm23-H1 mediated suppression.
authors.affiliation: Department of Microbiology and Tumor Virology Program, Abramson Comprehensive Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Abhik
authors.initials: A
authors.lastname: Saha
authors.forename: Erle S
authors.initials: ES
authors.lastname: Robertson
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000235:genetics / Q000378:metabolism*; D000956:Antigens, Viral / Q000235:genetics / Q000378:metabolism*; D002465:Cell Movement; D006801:Humans; D054778:NM23 Nucleoside Diphosphate Kinases / Q000235:genetics / Q000378:metabolism*; D009362:Neoplasm Metastasis; D009858:Oncogenic Viruses / Q000235:genetics / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism*; D014412:Tumor Virus Infections / Q000201:enzymology* / Q000235:genetics / Q000473:pathology
chemical_list: D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D054778:NM23 Nucleoside Diphosphate Kinases; D025521:Tumor Suppressor Proteins; C517938:NME1 protein, human