title: Gene expression and behaviour in mouse models of HD.
abstract: Huntington's disease (HD) is an autosomal dominant neurodegenerative disease, resulting in expansion of the CAG repeat in exon 1 of the HTT gene. The resulting mutant huntingtin protein has been implicated in the disruption of a variety of cellular functions, including transcription. Mouse models of HD have been central to the development of our understanding of gene expression changes in this disease, and are now beginning to elucidate the relationship between gene expression and behaviour. Here, we review current mouse models of HD and their characterisation in terms of gene expression. In addition, we look at how this can inform behaviours observed in mouse models of disease. The relationship between gene expression and behaviour in mouse models of HD is important, as this will further our knowledge of disease progression and its underlying molecular events, highlight new treatment targets, and potentially provide new biomarkers for therapeutic trials.
authors.affiliation: Department of Psychological Medicine, MRC centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Wales, UK.
authors.forename: K R
authors.initials: KR
authors.lastname: Bowles
authors.forename: S P
authors.initials: SP
authors.lastname: Brooks
authors.forename: S B
authors.initials: SB
authors.lastname: Dunnett
authors.forename: L
authors.initials: L
authors.lastname: Jones
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D006801:Humans; D006816:Huntington Disease / Q000235:genetics*; D051379:Mice; D008822:Mice, Transgenic; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins; C493231:Slc6a4 protein, mouse