title: Cognitive and affective empathy in depression linked to executive control.
abstract: Depression has been linked to executive dysfunction and emotion recognition impairments, associated with abnormalities in fronto-temporal and subcortical brain regions. Little is known about changes of different empathy subcomponents during depression, with potential impairments being related to the interpersonal difficulties of depressed patients. Twenty patients treated for an episode of unipolar depression and 20 matched healthy controls were assessed. Measures of dispositional and behavioural empathy components were administered along with tests of cognitive flexibility, response inhibition and working memory. Relative to controls, depressed patients showed higher self-reported dispositional empathy scores, mainly driven by increased personal distress scores. Patients and controls did not differ significantly in terms of behavioural cognitive empathy, empathic concern and personal affective involvement or in their executive function performance. In the patients, cognitive flexibility and response inhibition accuracy were associated with behavioural empathy. While an increased disposition towards feeling personal distress in response to other people's suffering seems to be in generally related to depressive symptoms, behavioural empathy might depend on the functional integrity of executive control during an episode of clinical depression. Impairments in this regard could contribute to the interpersonal difficulties depressed patients are frequently faced with which might have important implications for treatment.
authors.affiliation: Institute of Cognitive Neuroscience, Dept. of Neuropsychology, Ruhr-University Bochum, Germany. PatriIa.Thoma@rub.de
authors.forename: Patrizia
authors.initials: P
authors.lastname: Thoma
authors.forename: Iwona
authors.initials: I
authors.lastname: Zalewski
authors.forename: Heinrich Graf
authors.initials: HG
authors.lastname: von Reventlow
authors.forename: Christine
authors.initials: C
authors.lastname: Norra
authors.forename: Georg
authors.initials: G
authors.lastname: Juckel
authors.forename: Irene
authors.initials: I
authors.lastname: Daum
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D003072:Cognition Disorders / Q000209:etiology*; D003863:Depression / Q000150:complications* / Q000523:psychology*; D004645:Empathy; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D007360:Intelligence; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D057566:Self Report; D013223:Statistics as Topic