title: Decreased expression of ATP6V1H in type 2 diabetes: a pilot report on the diabetes risk study in Mexican Americans.
abstract: OBJECTIVE
  Previous studies in mice and humans observed down-regulation of the gene expression of ATP6V1H associated with type 2 diabetes. This study identified prospectively changes in ATP6V1H expression before and after overt diabetes.
  
  
  METHODS
  Expression of ATP6V1H in peripheral blood was compared pre and post development of diabetes in nine individuals.
  
  
  RESULTS
  Considerable variation of ATP6V1H mRNA levels was observed between different individuals. However, within each individual the decrease in expression of ATP6V1H with the development of diabetes was highly statistically significant.
  
  
  CONCLUSIONS
  ATP6V1H may represent a critical molecular mechanism involved in the development of type 2 diabetes and its compilations through its important regulatory effect on vacuolar-ATPase activity.
authors.affiliation: Division of Epidemiology, Human Genetics and Environmental Sciences, Brownsville Regional Campus, The University of Texas School of Public Health, Brownsville, TX, USA.
authors.forename: Melanie F
authors.initials: MF
authors.lastname: Molina
authors.forename: Hui-Qi
authors.initials: HQ
authors.lastname: Qu
authors.forename: Anne R
authors.initials: AR
authors.lastname: Rentfro
authors.forename: Saraswathy
authors.initials: S
authors.lastname: Nair
authors.forename: Yang
authors.initials: Y
authors.lastname: Lu
authors.forename: Craig L
authors.initials: CL
authors.lastname: Hanis
authors.forename: Joseph B
authors.initials: JB
authors.lastname: McCormick
authors.forename: Susan P
authors.initials: SP
authors.lastname: Fisher-Hoch
mesh_terms: D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics*; D015536:Down-Regulation; D006801:Humans; D008297:Male; D017058:Mexican Americans; D008875:Middle Aged; D010865:Pilot Projects; D012333:RNA, Messenger / Q000096:biosynthesis; D012306:Risk; D014018:Tissue Distribution; D059467:Transcriptome; D014481:United States / Q000453:epidemiology / Q000208:ethnology; D025262:Vacuolar Proton-Translocating ATPases / Q000097:blood / Q000235:genetics
chemical_list: D012333:RNA, Messenger; C567969:ATP6V1H protein, human; D025262:Vacuolar Proton-Translocating ATPases