title: Retrospective hemolysis comparison between patients with centrifugal biventricular assist and left ventricular assist devices.
abstract: Little is known about the hemolysis rate in the case of concomitant implantation of two continuous flow pumps for the treatment of biventricular heart failure. We present a retrospective study comparing the hemolysis parameters in patients supported with one implantable centrifugal pump of the type HeartWare HVAD used as a left ventricular assist device (LVAD) and with two pumps as a biventricular assist device (BiVAD). A total of 20 consecutive patients who received HeartWare BiVAD (n = 10) and LVAD (n = 10) support at our institution between September 2009 and September 2010 were examined. Hemolysis- and anemia-related parameters were analyzed after 2 weeks, 5 weeks, 3 months, and 6 months of support. Preoperative levels of hemoglobin, lactate dehydrogenase (LDH), and total bilirubin were similar in both groups. There were no differences in LDH, plasma-free hemoglobin (fHB), or total bilirubin levels postoperatively for up to 6 months. Only the haptoglobin level was lower in BiVAD recipients up to 3 months after surgery: 2nd week (63.5 [range: 8-237] mg/dl vs. 151 [range: 11-263] mg/dl, p = 0.05), 5th week (67 [range: 8-196] mg/dl vs. 215 [range: 56-292] mg/dl, p = 0.046), and after 3rd month (42 [range: 8-205] mg/dl vs. 220 [range: 157-256] mg/dl, p = 0.048). Our retrospective analysis of BiVAD HeartWare and LVAD HeartWare recipients showed a lack of a clinically important degree of hemolysis when two centrifugal HeartWare pumps are used for biventricular support.
authors.affiliation: Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin, Germany. stepanenko@dhzb.de
authors.forename: Alexander
authors.initials: A
authors.lastname: Stepanenko
authors.forename: Thomas
authors.initials: T
authors.lastname: Krabatsch
authors.forename: Ewald
authors.initials: E
authors.lastname: Hennig
authors.forename: Friedrich
authors.initials: F
authors.lastname: Kaufmann
authors.forename: Beate
authors.initials: B
authors.lastname: Jurmann
authors.forename: Nikolay
authors.initials: N
authors.lastname: Dranishnikov
authors.forename: Hans B
authors.initials: HB
authors.lastname: Lehmkuhl
authors.forename: Miralem
authors.initials: M
authors.lastname: Pasic
authors.forename: Yuguo
authors.initials: Y
authors.lastname: Weng
authors.forename: Roland
authors.initials: R
authors.lastname: Hetzer
authors.forename: Evgenij V
authors.initials: EV
authors.lastname: Potapov
mesh_terms: D000328:Adult; D000368:Aged; D000740:Anemia / Q000473:pathology; D000925:Anticoagulants / Q000737:chemistry; D004867:Equipment Design; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000601:surgery*; D006353:Heart-Assist Devices; D006454:Hemoglobins / Q000737:chemistry / Q000378:metabolism; D006461:Hemolysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D012189:Retrospective Studies; D016896:Treatment Outcome; D016277:Ventricular Function, Left
chemical_list: D000925:Anticoagulants; D006454:Hemoglobins