title: Short and long-term outcome of patients with severe acute kidney injury requiring renal replacement therapy.
abstract: BACKGROUND
  Severe acute kidney injury (AKI) occurs in 2-7% of all hospital admissions and is an independent poor prognostic marker. Nevertheless, information on the long-term outcome of AKI and the factors influencing this is limited.
  
  
  OBJECTIVE
  To describe the short- and long-term outcome of patients requiring renal replacement therapy (RRT) for severe AKI and to examine factors affecting patient survival and renal recovery.
  
  
  METHODS
  Single centre retrospective analysis of 481 consecutive patients over a period of 39 months.
  
  
  RESULTS
  12 months.
  
  
  METHODS
  overall mortality and RRT dependency at 30 days, 90 days and 1 year.
  
  
  RESULTS
  Survival at 30 days, 90 days and 1 year was 54.4, 47.2 and 37.6%, respectively. RRT independency at 30 days, 90 days and 1 year was 35.2, 27.2 and 25.8%, respectively. Of those RRT independent at 90 days, 55% had ongoing chronic kidney disease. There were two distinct groups of patients: Group A (haemofiltration in ITU) and Group B (intermittent haemodialysis in the renal unit). Patient survival was worse in Group A while RRT independence was higher. Independent predictors of survival included renal cause of AKI and lower CI score in Group A and renal or post-renal cause of AKI, younger age and the absence of malignancy in Group B. Independent predictors of renal recovery included the presence of sepsis in Group A and pre- or post-renal cause of AKI in Group B.
  
  
  CONCLUSIONS
  The short- and long-term survival outcome of severe AKI requiring RRT remains poor. Among those who survive, a significant number either continue to require RRT or have residual renal impairment necessitating ongoing follow-up.
authors.affiliation: Renal Department, Birmingham Heartlands Hospital, Heart of England NHS Foundation Trust, Birmingham, UK. khaiping@doctors.org.uk
authors.forename: K P
authors.initials: KP
authors.lastname: Ng
authors.forename: D
authors.initials: D
authors.lastname: Chanouzas
authors.forename: B
authors.initials: B
authors.lastname: Fallouh
authors.forename: J
authors.initials: J
authors.lastname: Baharani
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000401:mortality / Q000628:therapy*; D000368:Aged; D000369:Aged, 80 and over; D042241:Early Diagnosis; D005919:Glomerular Filtration Rate; D006801:Humans; D008875:Middle Aged; D017582:Renal Replacement Therapy / Q000379:methods* / Q000401:mortality; D012189:Retrospective Studies; D012307:Risk Factors; D018805:Sepsis / Q000150:complications; D012737:Sex Factors; D016019:Survival Analysis; D016896:Treatment Outcome