title: Denture stomatitis treated with photodynamic therapy: five cases.
abstract: OBJECTIVE
  Photodynamic therapy (PDT) is an effective method for Candida spp. inactivation in vitro and in vivo, but as yet, no clinical trial has been conducted. This report describes 5 cases of denture stomatitis (DS) treated with PDT.
  
  
  METHODS
  Five subjects with clinical and microbiologic diagnosis of DS were submitted to 6 sessions of PDT 3 times a week for 15 days. In each session, patients' dentures and palates were sprayed with 500 mg/L Photogem, and, after 30 minutes of incubation, irradiated by light-emitting diode light source at 455 nm (37.5 and 122 J/cm(2), respectively). Cultures of Candida spp. from dentures and palates and standard photographs of the palates were taken at baseline (day 0), at the end of the treatment (day 15), and at follow-up time intervals (days 30 and 60).
  
  
  RESULTS
  Four patients showed clinical resolution of DS (no inflammation) after PDT sessions, and only 1 subject demonstrated reduction in palatal inflammation. Recurrence of DS was observed in 2 patients during the follow-up period.
  
  
  CONCLUSIONS
  PDT appears to be an alternative treatment for DS.
authors.affiliation: Dentistry School, São Francisco University, Bragança Paulista, São Paulo, Brazil.
authors.forename: Ewerton Garcia de Oliveira
authors.initials: EG
authors.lastname: Mima
authors.forename: Ana Cláudia
authors.initials: AC
authors.lastname: Pavarina
authors.forename: Mariana Montenegro
authors.initials: MM
authors.lastname: Silva
authors.forename: Daniela Garcia
authors.initials: DG
authors.lastname: Ribeiro
authors.forename: Carlos Eduardo
authors.initials: CE
authors.lastname: Vergani
authors.forename: Cristina
authors.initials: C
authors.lastname: Kurachi
authors.forename: Vanderlei Salvador
authors.initials: VS
authors.lastname: Bagnato
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002175:Candida / Q000528:radiation effects*; D003827:Denture, Complete, Upper / Q000009:adverse effects* / Q000382:microbiology; D005260:Female; D005500:Follow-Up Studies; D006414:Hematoporphyrin Photoradiation / Q000379:methods*; D006415:Hematoporphyrins / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010159:Palate / Q000382:microbiology / Q000528:radiation effects; D017319:Photosensitizing Agents / Q000627:therapeutic use; D013282:Stomatitis, Denture / Q000188:drug therapy* / Q000382:microbiology; D016896:Treatment Outcome
chemical_list: D006415:Hematoporphyrins; D017319:Photosensitizing Agents