title: Migraine: Role of the TRESK two-pore potassium channel.
abstract: Migraine is a severe episodic headache disorder affecting one in five people. Genetic studies have identified mutations in the CACNA1, ATP1A2 and SCN1A genes in the rare familial hemiplegic migraine. Recently, a mutation in the KCNK18 gene, encoding the TRESK two-pore domain potassium channel, was described in a large family with migraine with aura. This review will elaborate on the possible role of the TRESK channel in regulating neuronal excitability, its role in migraine pathogenesis, and on promising therapeutic opportunities targeting this channel.
authors.affiliation: Center of Excellence in Neuroscience of the Université de Montréal, Montreal, Quebec, Canada. Ronald.G.Lafreniere@gmail.com
authors.forename: Ronald G
authors.initials: RG
authors.lastname: Lafrenière
authors.forename: Guy A
authors.initials: GA
authors.lastname: Rouleau
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D019703:Calcineurin / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D004827:Epilepsy / Q000150:complications / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D016368:Frameshift Mutation; D015870:Gene Expression; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008881:Migraine Disorders / Q000150:complications / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism; D011188:Potassium / Q000378:metabolism*; D015221:Potassium Channels / Q000235:genetics* / Q000378:metabolism; D055503:Protein Multimerization; D017434:Protein Structure, Tertiary; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use; D014363:Tryptamines / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; C476574:KCNK18 protein, human; D009419:Nerve Tissue Proteins; D015221:Potassium Channels; D017366:Serotonin Receptor Agonists; D014363:Tryptamines; D019703:Calcineurin; D011188:Potassium; D002118:Calcium