title: Molecularly imprinted hydroxyapatite thin film for bilirubin recognition.
abstract: A novel piezoelectric sensor has been developed for bilirubin (BR) detection, based on the modification of molecularly imprinted hydroxyapatite (HAP) film onto a quartz crystal by molecular imprinting and surface sol-gel technique. The performance of the developed BR biosensor was evaluated and the results indicated that a sensitive BR biosensor could be fabricated. The obtained BR biosensor presents high-selectivity monitoring of BR, better reproducibility, shorter response time (37 min), wider linear range (0.05-80μM) and lower detection limit (0.01μM). The analytical application of the BR biosensor confirms the feasibility of BR detection in serum sample.
authors.affiliation: Institute of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo 454000, China. zhengpengyang@yahoo.com.cn
authors.forename: Zhengpeng
authors.initials: Z
authors.lastname: Yang
authors.forename: Chunjing
authors.initials: C
authors.lastname: Zhang
mesh_terms: D001663:Bilirubin / Q000032:analysis* / Q000097:blood; D015374:Biosensing Techniques / Q000379:methods* / Q000706:statistics & numerical data; D017886:Durapatite; D006801:Humans; D057230:Limit of Detection; D008855:Microscopy, Electron, Scanning; D054802:Molecular Imprinting; D044367:Phase Transition; D058525:Quartz Crystal Microbalance Techniques / Q000379:methods
chemical_list: D017886:Durapatite; D001663:Bilirubin