title: Wnt/Myc interactions in intestinal cancer: partners in crime.
abstract: Loss of the APC (adenomatous polyposis coli) gene in colorectal cancer leads to a rapid deregulation of TCF/LEF target genes. Of all these target genes, the transcription factor c-MYC appears the most critical. In this review we will discuss the interplay of Wnt and c-MYC signaling during intestinal homeostasis and transformation. Furthermore, we will discuss recent data showing that further deregulation of c-MYC levels during colorectal carcinogenesis may drive tumor progression. Moreover, understanding these additional control mechanisms may allow targeting of c-MYC during colorectal carcinogenesis.
authors.affiliation: Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow, Scotland G61 1BD, UK.
authors.forename: Kevin
authors.initials: K
authors.lastname: Myant
authors.forename: Owen J
authors.initials: OJ
authors.lastname: Sansom
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000235:genetics* / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D004843:Epistasis, Genetic / Q000502:physiology*; D016259:Genes, myc; D006801:Humans; D007414:Intestinal Neoplasms / Q000235:genetics* / Q000378:metabolism; D008954:Models, Biological; D014925:Wit and Humor as Topic; D051153:Wnt Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D051153:Wnt Proteins