title: Linezolid and lactic acidosis: a role for lactate monitoring with long-term linezolid use in children.
abstract: Linezolid administration has been associated with lactic acidosis in adults; however, the same phenomenon has not been reported in children. Mitochondrial protein synthesis inhibition is a demonstrated mechanism for toxicity, which therefore may manifest as lactic acidosis. Three cases of linezolid-associated lactic acidosis in children are reported to reinforce the need for pediatric caregivers to be vigilant of this potential side effect.
authors.affiliation: Department of Pediatric Critical Care Medicine, Division of Infectious Disease, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA. suer4@upmc.edu
authors.forename: Erik
authors.initials: E
authors.lastname: Su
authors.forename: Kelli
authors.initials: K
authors.lastname: Crowley
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Carcillo
authors.forename: Marian G
authors.initials: MG
authors.lastname: Michaels
mesh_terms: D000081:Acetamides / Q000009:adverse effects* / Q000494:pharmacology; D000140:Acidosis, Lactic / Q000097:blood / Q000139:chemically induced*; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000494:pharmacology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007223:Infant; D019344:Lactic Acid / Q000097:blood*; D000069349:Linezolid; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D023303:Oxazolidinones / Q000009:adverse effects* / Q000494:pharmacology
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D019344:Lactic Acid; D000069349:Linezolid