title: Immunophenotyping of circulating T cells in a mucosal leishmaniasis patient coinfected with HIV.
abstract: HIV coinfection modifies the clinical course of leishmaniasis by promoting a Th2 pattern of cytokine production. However, little information is available regarding the lymphocytic response in untreated coinfected patients. This work presents the immunophenotyping of Leishmania-stimulated T cells from a treatment-naÏve HIV+ patient with ML. Leishmania braziliensis antigens induced CD69 expression on CD3+CD4+ and CD3+CD8+ cells. It also increased IL-4 intracellular staining on CD3+CD4+GATA3- population and decreased the percentage of CD3+CD4+IL-17+ cells. This suggests that modulations in the IL-4R/STAT6 pathway and the Th17 population may serve as parasitic evasion mechanisms in HIV/ML. Further studies are required to confirm these results.
authors.affiliation: Laboratório de Imunologia, Departamento de Ciências Biológicas, Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brasil. luciocastellano@ccs.ufpb.br
authors.forename: Lúcio Roberto
authors.initials: LR
authors.lastname: Castellano
authors.forename: Mauricio
authors.initials: M
authors.lastname: Llaguno
authors.forename: Marcos Vinícius
authors.initials: MV
authors.lastname: Silva
authors.forename: Juliana Reis
authors.initials: JR
authors.lastname: Machado
authors.forename: Dalmo
authors.initials: D
authors.lastname: Correia
authors.forename: Mario León
authors.initials: ML
authors.lastname: Silva-Vergara
authors.forename: Virmondes
authors.initials: V
authors.lastname: Rodrigues
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000276:immunology*; D000328:Adult; D006801:Humans; D016130:Immunophenotyping; D007892:Leishmania braziliensis / Q000276:immunology*; D007897:Leishmaniasis, Mucocutaneous / Q000276:immunology*; D008297:Male; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*