title: Membrane lipidomics for the discovery of new antiparasitic drug targets.
abstract: Advances in lipid separation methods and mass spectrometry technologies allow the fine characterization of the lipidome of parasites, ranging from unicellular protists to worms, which cause threatening infections in vertebrates, including humans. Specific lipid structures or lipid metabolic pathways can inspire the development of novel antiparasitic drugs. Changes in the lipid balance in membranes of parasites can also provide clues on the dynamics of drugs and some mechanisms of drug resistance. This review highlights recent trends in parasite lipidomics, combined with functional analyses, for the discovery of novel targets and the development of novel drugs.
authors.affiliation: Laboratoire de Physiologie Cellulaire Végétale, UMR 5168, CNRS-CEA-INRA-Université Joseph Fourier, Institut de Recherches en Sciences et Technologies pour le Vivant, CEA Grenoble, 17 rue des Martyrs, Grenoble, France. eric.marechal@cea.fr
authors.forename: Eric
authors.initials: E
authors.lastname: Maréchal
authors.forename: Mickaël
authors.initials: M
authors.lastname: Riou
authors.forename: Dominique
authors.initials: D
authors.lastname: Kerboeuf
authors.forename: Frédéric
authors.initials: F
authors.lastname: Beugnet
authors.forename: Pierre
authors.initials: P
authors.lastname: Chaminade
authors.forename: Philippe M
authors.initials: PM
authors.lastname: Loiseau
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000494:pharmacology; D002462:Cell Membrane; D002853:Chromatography, Liquid / Q000379:methods*; D055808:Drug Discovery; D004351:Drug Resistance; D006801:Humans; D050356:Lipid Metabolism; D013058:Mass Spectrometry / Q000379:methods*; D008563:Membrane Lipids / Q000737:chemistry* / Q000302:isolation & purification*; D010271:Parasites / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*
chemical_list: D000977:Antiparasitic Agents; D008563:Membrane Lipids