title: Perspectives of biotechnological production of L-ribose and its purification.
abstract: L-ribose is a non-natural and expensive sugar that can be used as an important intermediate for the synthesis of L-nucleoside analogues, which are used as antiviral drugs. In contrast to chemical production, biotechnological methods can produce L-ribose from biomass under environmentally friendly conditions. In this mini-review, various strategies for synthesizing L-ribose by applying microorganisms and their enzymes are discussed, including microbial biotransformation and biocatalysis by engineering bacteria. Furthermore, subsequent isolation-and-purification techniques, as an integral step in the whole process, are accordingly described, containing the special introduction of a promising strategy of L-ribose separation. Particularly, further researches and outlook for the improvement of L-ribose preparation was solely stressed. Compared with each method, this mini-review provides a panorama of respective advantages and disadvantages existing in them.
authors.affiliation: School of Chemistry and Bioengineering, Suzhou University of Science and Technology, Suzhou, 215011, People's Republic of China.
authors.forename: Chao
authors.initials: C
authors.lastname: Hu
authors.forename: Liangzhi
authors.initials: L
authors.lastname: Li
authors.forename: Yayue
authors.initials: Y
authors.lastname: Zheng
authors.forename: Lilian
authors.initials: L
authors.lastname: Rui
authors.forename: Cuiying
authors.initials: C
authors.lastname: Hu
mesh_terms: D055162:Biocatalysis; D001709:Biotechnology / Q000379:methods*; D001711:Biotransformation; D005285:Fermentation; D007218:Industrial Microbiology / Q000379:methods*; D060847:Metabolic Engineering; D012266:Ribose / Q000378:metabolism*
chemical_list: D012266:Ribose