title: Measurement of phase synchrony of coupled segmentation clocks.
abstract: The temporal behavior of segmentation clock oscillations shows phase synchrony via mean field like coupling of delta protein restricting to nearest neighbors only, in a configuration of cells arranged in a regular three dimensional array. We found the increase of amplitudes of oscillating dynamical variables of the cells as the activation rate of delta-notch signaling is increased, however, the frequencies of oscillations are decreased correspondingly. Our results show the phase transition from desynchronized to synchronized behavior by identifying three regimes, namely, desynchronized, transition and synchronized regimes supported by various qualitative and quantitative measurements.
authors.affiliation: Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India.
authors.forename: Md Jahoor
authors.initials: MJ
authors.lastname: Alam
authors.forename: Latika
authors.initials: L
authors.lastname: Bhayana
authors.forename: Gurumayum Reenaroy
authors.initials: GR
authors.lastname: Devi
authors.forename: Heisnam Dinachandra
authors.initials: HD
authors.lastname: Singh
authors.forename: R K Brojen
authors.initials: RK
authors.lastname: Singh
authors.forename: B Indrajit
authors.initials: BI
authors.lastname: Sharma
mesh_terms: D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D002468:Cell Physiological Phenomena; D019295:Computational Biology; D003198:Computer Simulation; D018507:Gene Expression Regulation, Developmental; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D008954:Models, Biological; D051880:Receptors, Notch / Q000378:metabolism; D012815:Signal Processing, Computer-Assisted; D015398:Signal Transduction; D014714:Vertebrates
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D051880:Receptors, Notch; C064045:delta protein