title: Down-regulation of adiponectin in patients with familial Mediterranean fever during attack-free period.
abstract: To evaluate the circulating levels of adipokines (leptin and adiponectin) and ghrelin in patients with familial Mediterranean fever (FMF) and also to assess the relationships between these molecules and disease-related parameters. Forty-eight FMF patients in attack-free period (31 men, [M], 17 women, [F], mean age 35.8 ± 8.6 years, and a mean body mass index [BMI] of 24.7 ± 3.1) and 40 age-, sex-, and BMI-matched healthy controls (24 M, 16 F, mean age 35.5 ± 8.5 years, and a mean BMI of 24.5 ± 2.8) were included in the study. Patients and controls with a history of any other chronic diseases and obese or underweight subjects were excluded. High-sensitive C-reactive protein (hs-CRP), leptin, adiponectin, and total ghrelin concentrations were studied. Age, sex, BMI, waist circumference, and smoking status were similar between FMF patients and controls (P > 0.05). Adipose tissue-derived molecules including leptin, and adiponectin were lower than healthy controls but only adiponectin levels reached the statistically significance (16.7 ± 8.9 ng/ml vs. 27.7 ± 15.9 ng/ml, P < 0.001) and leptin concentrations just missed significance (25.2 ± 16.2 ng/ml vs. 34.9 ± 27.2 ng/ml, P = 0.051). Ghrelin concentrations were not different between the groups. Adiponectin levels were significantly and negatively correlated with hs-CRP (P < 0.05, r = -0.24). The results of this study suggest that low-grade chronic inflammation during attack-free period in FMF patients may suppress adiponectin production or low levels of adiponectin might contribute to subclinical inflammation in these patients.
authors.affiliation: Department of Rheumatology, Dokuz Eylul University School of Medicine, Tip Fakultesi, Ic Hastaliklari ABD, Romatoloji BD, 35340 Balcova, Izmir, Turkey.
authors.forename: Vedat
authors.initials: V
authors.lastname: Gerdan
authors.forename: Ismail
authors.initials: I
authors.lastname: Sari
authors.forename: Didem
authors.initials: D
authors.lastname: Kozacı
authors.forename: Fatos
authors.initials: F
authors.lastname: Önen
authors.forename: Feride
authors.initials: F
authors.lastname: Yüksel
authors.forename: Ozgül
authors.initials: O
authors.lastname: Soysal
authors.forename: Dilek
authors.initials: D
authors.lastname: Solmaz
authors.forename: Necati
authors.initials: N
authors.lastname: Günay
authors.forename: Nurullah
authors.initials: N
authors.lastname: Akkoc
authors.forename: Servet
authors.initials: S
authors.lastname: Akar
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D015536:Down-Regulation; D010505:Familial Mediterranean Fever / Q000097:blood*; D005260:Female; D054439:Ghrelin / Q000097:blood; D006801:Humans; D020738:Leptin / Q000097:blood; D008297:Male; D012075:Remission, Spontaneous; D014421:Turkey
chemical_list: D052242:Adiponectin; D054439:Ghrelin; D020738:Leptin; D002097:C-Reactive Protein