title: Relationship between chemical structure and biological activity of alkali metal o-, m- and p-anisates. FT-IR and microbiological studies.
abstract: In this work we investigated relationship between molecular structure of alkali metal o-, m-, p-anisate molecules and their antimicrobial activity. For this purpose FT-IR spectra for lithium, sodium, potassium, rubidium and caesium anisates in solid state and solution were recorded, assigned and analysed. Microbial activity of studied compounds was tested against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Proteus vulgaris. In order to evaluate the dependency between chemical structure and biological activity of alkali metal anisates the statistical analysis (multidimensional regression and principal component) was performed for selected wavenumbers from FT-IR spectra and parameters that describe microbial activity of anisates. The obtained statistical equations show the existence of correlation between molecular structure of anisates and their biological properties.
authors.affiliation: Division of Chemistry, Białystok University of Technology, Zamenhofa 29, 15-435 Białystok, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Kalinowska
authors.forename: J
authors.initials: J
authors.lastname: Piekut
authors.forename: W
authors.initials: W
authors.lastname: Lewandowski
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology; D001565:Benzoates / Q000737:chemistry; D004926:Escherichia coli / Q000378:metabolism; D007477:Ions; D008670:Metals / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D015394:Molecular Structure; D025341:Principal Component Analysis; D011514:Proteus vulgaris / Q000378:metabolism; D011550:Pseudomonas aeruginosa / Q000378:metabolism; D012044:Regression Analysis; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*; D013211:Staphylococcus aureus / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D001565:Benzoates; D007477:Ions; D008670:Metals