title: From Notch signaling to fine-grained patterning: Modeling meets experiments.
abstract: Notch signaling is the canonical signaling pathway between neighboring cells. It plays an important role in fine-grained patterning processes such as the formation of checkerboard-like differentiation patterns and sharp boundaries between developing tissues. While detailed information about many of the genes and proteins involved have been identified, we still lack a quantitative mechanistic understanding of these processes. Here we discuss several recent studies that provide novel insights into Notch-dependent patterning by combining mathematical models with quantitative experimental results. Such approaches allow identification of mechanisms and design principles controlling how patterns are generated in a reproducible and robust manner.
authors.affiliation: Department of Biochemistry & Molecular Biology, George S. Wise Faculty of Life Science, Tel-Aviv University, Ramat-Aviv 69978, Israel.
authors.forename: O
authors.initials: O
authors.lastname: Shaya
authors.forename: D
authors.initials: D
authors.lastname: Sprinzak
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000235:genetics*; D002454:Cell Differentiation / Q000235:genetics; D004330:Drosophila / Q000196:embryology / Q000235:genetics / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D008954:Models, Biological; D011499:Protein Processing, Post-Translational; D051880:Receptors, Notch / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D051880:Receptors, Notch