title: Fifteen years of large scale metabolic modeling of yeast: developments and impacts.
abstract: Since the first large-scale reconstruction of the Saccharomyces cerevisiae metabolic network 15 years ago the development of yeast metabolic models has progressed rapidly, resulting in no less than nine different yeast genome-scale metabolic models. Here we review the historical development of large-scale mathematical modeling of yeast metabolism and the growing scope and impact of applications of these models in four different areas: as guide for metabolic engineering and strain improvement, as a tool for biological interpretation and discovery, applications of novel computational framework and for evolutionary studies.
authors.affiliation: Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden.
authors.forename: Tobias
authors.initials: T
authors.lastname: Osterlund
authors.forename: Intawat
authors.initials: I
authors.lastname: Nookaew
authors.forename: Jens
authors.initials: J
authors.lastname: Nielsen
mesh_terms: D016681:Genome, Fungal / Q000235:genetics; D060847:Metabolic Engineering / Q000379:methods*; D053858:Metabolic Networks and Pathways; D008954:Models, Biological; D015003:Yeasts / Q000235:genetics / Q000378:metabolism*