title: Tritoniopsins A-D, cladiellane-based diterpenes from the South China Sea nudibranch Tritoniopsis elegans and its prey Cladiella krempfi.
abstract: Four diterpenes, tritoniopsins A-D (1-4), have been isolated from the South China Sea nudibranch Tritoniopsis elegans and its prey, the soft coral Cladiella krempfi. They display an unprecedented pyran ring in the cladiellane framework, thus representing a novel cladiellane-based diterpene family. Their structures have been mainly characterized by NMR and mass spectrometric techniques, whereas the relative configuration of compound 1 was secured by X-ray analysis. Antiproliferative assays on tumor and nontumor cell lines have been carried out for the main metabolite, tritoniopsin B (2).
authors.affiliation: Istituto di Chimica Biomolecolare (ICB-CNR), Via Campi Flegrei, 34-80078 I Pozzuoli, Napoli, Italy. lciavatta@icb.cnr.it
authors.forename: Maria Letizia
authors.initials: ML
authors.lastname: Ciavatta
authors.forename: Emiliano
authors.initials: E
authors.lastname: Manzo
authors.forename: Ernesto
authors.initials: E
authors.lastname: Mollo
authors.forename: Carlo Andrea
authors.initials: CA
authors.lastname: Mattia
authors.forename: Consiglia
authors.initials: C
authors.lastname: Tedesco
authors.forename: Carlo
authors.initials: C
authors.lastname: Irace
authors.forename: Yue-Wei
authors.initials: YW
authors.lastname: Guo
authors.forename: Xiu-Bao
authors.initials: XB
authors.lastname: Li
authors.forename: Guido
authors.initials: G
authors.lastname: Cimino
authors.forename: Margherita
authors.initials: M
authors.lastname: Gavagnin
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D049851:Gastropoda / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes; C562292:tritoniopsin B