title: Acute kidney injury in a girl with ulcerative colitis and cytomegalovirus-induced focal segmental glomerular sclerosis.
abstract: BACKGROUND
  Mesalamine or 5-aminosalicylic acid (5-ASA) has proven efficacy in treating patients with ulcerative colitis (UC). Although mesalamine is considered safe, it has been associated with acute interstitial nephritis and renal failure.
  
  
  METHODS
  Herein we present a case of a child with UC who developed acute renal failure on mesalamine therapy.
  
  
  RESULTS
  A 15-year-old African-American girl with well-controlled UC presented to the Johns Hopkins Hospital with a four-day history of high fever, malaise, generalized body aches, and productive non-bloody cough. Over the next three days, she developed acute renal failure with fluid retention, and elevated serum creatinine and blood urea nitrogen. A kidney biopsy showed drug induced acute interstitial nephritis and focal segmental glomerulosclerosis with viral inclusion bodies likely secondary to cytomegalovirus.
  
  
  CONCLUSIONS
  When treating UC patients with a history of underlying renal disease, it is advised to carefully monitor renal function while on mesalamine therapy.
authors.affiliation: Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Sankar R
authors.initials: SR
authors.lastname: Chirumamilla
authors.forename: Chun
authors.initials: C
authors.lastname: He
authors.forename: Lorraine C
authors.initials: LC
authors.lastname: Racusen
authors.forename: Ann O
authors.initials: AO
authors.lastname: Scheimann
authors.forename: Carmen
authors.initials: C
authors.lastname: Cuffari
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D000293:Adolescent; D003093:Colitis, Ulcerative / Q000150:complications*; D003586:Cytomegalovirus Infections / Q000150:complications*; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications* / Q000821:virology*; D006801:Humans