title: Lack of correlation between first trimester maternal serum 25-hydroxyvitamin D levels and ultrasound measured crown-rump length and nuchal translucency.
abstract: BACKGROUND
  Vitamin D regulates the human genome and it is thought to influence the fetal growth and development, but its relation to early ultrasound fetal measures is still unknown.
  
  
  OBJECTIVE
  To assess first trimester 25-hydroxyvitamin D [25(OH)D] maternal serum status and correlate with ultrasound crown-rump length (CRL) and nuchal translucency (NT) measurements.
  
  
  METHODS
  In this cross-sectional study, women with singleton pregnancies undergoing the first trimester standard two-dimensional ultrasound scan for fetal anomalies were included: CRL (n = 498) and NT (n = 487). Concomitantly, maternal serum 25(OH)D levels were also measured.
  
  
  RESULTS
  Median serum 25(OH)D levels for the entire sample (n = 498) was 27.4 ng/mL (interquartile range 20.9-32.7). Serum 25(OH)D was adequate (≥ 30 ng/mL) in only 36.1% of gravids, whereas levels were found to be insufficient (20-29.99 ng/mL) in 41.2% and deficient (< 20 ng/mL) in 22.7%. No significant correlation was found between the serum 25(OH)D levels and the measured ultrasound parameters.
  
  
  CONCLUSIONS
  First trimester 25(OH)D levels did not correlate to fetal ultrasound measurements.
authors.affiliation: Departamento de Obstetricia y Ginecología, Hospital Torrecárdenas, Paraje Torrecárdenas s/n, 04009 Almeria, Spain. amfa257@yahoo.es
authors.forename: Ana M
authors.initials: AM
authors.lastname: Fernández-Alonso
authors.forename: Gabriel
authors.initials: G
authors.lastname: Fiol-Ruiz
authors.forename: Peter
authors.initials: P
authors.lastname: Chedraui
authors.forename: Faustino R
authors.initials: FR
authors.lastname: Pérez-López
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D018568:Crown-Rump Length; D005260:Female; D006801:Humans; D048208:Nuchal Translucency Measurement; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood*; D013223:Statistics as Topic; D016216:Ultrasonography, Prenatal; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D