title: A new steroidal saponin with antiinflammatory and antiulcerogenic properties from the bulbs of Allium ampeloprasum var. porrum.
abstract: A new steroidal saponin was isolated from the bulbs of Allium ampeloprasum var. porrumL. On the basis of chemical evidence, comprehensive spectroscopic analyses and comparison of known compounds, its structure was established as (3β,5α,6β,25R)-6-[(β-D-glucopyranosyl)oxy]-spirostan-3-yl O-β-D-glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→3)]-β-D-galactopyranoside. Results of the present study indicated that the steroidal saponin showed haemolytic effects in the in vitro assays and demonstrated antiinflammatory activity and gastroprotective property using in vivo models.
authors.affiliation: Laboratório de Química de Plantas Medicinais, Núcleo de Pesquisas de Produtos Naturais, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, P.O. Box 68045, CEP 21941-971 Rio de Janeiro, Brazil.
authors.forename: Camila Rodrigues
authors.initials: CR
authors.lastname: Adão
authors.forename: Bernadete Pereira
authors.initials: BP
authors.lastname: da Silva
authors.forename: José Paz
authors.initials: JP
authors.lastname: Parente
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D000897:Anti-Ulcer Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D000431:Ethanol; D053878:Hemolytic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D015394:Molecular Structure; D019697:Onions / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018517:Plant Roots; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D013150:Spirostans / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy
chemical_list: C571569:(3beta,5alpha,6beta,25R)-6-((beta-D-glucopyranosyl)oxy)spirostan-3-yl O-beta-D-glucopyranosyl-(1-2)-O-(beta-D-glucopyranosyl-(1-3))beta-D-galactopyranoside; D000893:Anti-Inflammatory Agents; D000897:Anti-Ulcer Agents; D053878:Hemolytic Agents; D010936:Plant Extracts; D012503:Saponins; D013150:Spirostans; D000431:Ethanol; D002351:Carrageenan