title: Serial nerve conduction studies provide insight into the pathophysiology of Guillain-Barré and Fisher syndromes.
abstract: The electrodiagnosis of Guillain-Barré syndrome (GBS) can be broadly divided into acute inflammatory demyelinating polyneuropathy (AIDP) and acute motor axonal neuropathy (AMAN). Fisher syndrome (FS) is a variant of GBS, although the underlying neuropathy of FS has yet to be established. Serial nerve conduction studies (NCS) can provide further insight into the likely pathophysiology by further subtyping of GBS and FS. We present a patient with an initial diagnosis of AIDP in whom repeated NCS revealed the AMAN variant. This led us to investigate serial NCS in five patients with GBS, FS and FS/GBS overlap presenting over a period of a year. Three patients with AIDP showed a gradual increase in distal motor latencies during the acute phase of illness. NCS of two patients with FS and FS/GBS overlap showed no demyelinating features suggesting underlying axonal neuropathy in this group of patients. The importance of serial NCS in establishing the underlying pattern of neuropathy in GBS and FS is further emphasized in this study. Larger studies incorporating serial NCS are required to confirm the observations seen in our case series especially when pathological studies are often not justified in this group of patients.
authors.affiliation: Division of Neurology, Department of Medicine, University of Malaya, Malaysia. nortina@um.edu.my
authors.forename: Nortina
authors.initials: N
authors.lastname: Shahrizaila
authors.forename: Khean Jin
authors.initials: KJ
authors.lastname: Goh
authors.forename: Norito
authors.initials: N
authors.lastname: Kokubun
authors.forename: Suhailah
authors.initials: S
authors.lastname: Abdullah
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Yuki
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D020275:Guillain-Barre Syndrome / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019846:Miller Fisher Syndrome / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology*; D009046:Motor Neurons / Q000473:pathology / Q000502:physiology; D009431:Neural Conduction / Q000502:physiology*; D011984:Sensory Receptor Cells / Q000473:pathology / Q000502:physiology