title: Comparative pharmacokinetics of perfluorohexanesulfonate (PFHxS) in rats, mice, and monkeys.
abstract: Perfluorohexanesulfonate (PFHxS) has been found in biological samples from wildlife and humans. The human geometric mean serum PFHxS elimination half-life has been estimated to be 2665days. A series of studies was undertaken to establish pharmacokinetic parameters for PFHxS in rats, mice, and monkeys after single administration with pharmacokinetic parameters determined by WinNonlin(®) software. Rats and mice appeared to be more effective at eliminating PFHxS than monkeys. With the exception of female rats, which had serum PFHxS elimination half-life of approximately 2 days, the serum elimination half-lives in the rodent species and monkeys approximated 1month and 4months, respectively, when followed over extended time periods (10-24weeks). Collectively, these studies provide valuable insight for human health risk assessment regarding the potential for accumulation of PFHxS in humans.
authors.affiliation: Environmental Chemistry Unit, Department of Materials and Environmental Chemistry, Stockholm University, SE-106 91 Stockholm, Sweden. Electronic address: maria.sundstrom@mmk.su.se.
authors.forename: Maria
authors.initials: M
authors.lastname: Sundström
authors.affiliation: Medical Department, 3M Company, St. Paul, MN 55144 United States. Electronic address: s.chang@mmm.com.
authors.forename: Shu-Ching
authors.initials: SC
authors.lastname: Chang
authors.affiliation: Southern Research Institute, Birmingham, AL 35255 United States. Electronic address: noker@southernresearch.org.
authors.forename: Patricia E
authors.initials: PE
authors.lastname: Noker
authors.affiliation: Southern Research Institute, Birmingham, AL 35255 United States; Samford University, Birmingham, AL 35229 United States. Electronic address: ggorman@samford.edu.
authors.forename: Gregory S
authors.initials: GS
authors.lastname: Gorman
authors.affiliation: Medical Department, 3M Company, St. Paul, MN 55144 United States. Electronic address: jahart@mmm.com.
authors.forename: Jill A
authors.initials: JA
authors.lastname: Hart
authors.affiliation: Medical Department, 3M Company, St. Paul, MN 55144 United States. Electronic address: djehresman@mmm.com.
authors.forename: David J
authors.initials: DJ
authors.lastname: Ehresman
authors.affiliation: Environmental Chemistry Unit, Department of Materials and Environmental Chemistry, Stockholm University, SE-106 91 Stockholm, Sweden. Electronic address: ake.bergman@mmk.su.se.
authors.forename: Åke
authors.initials: Å
authors.lastname: Bergman
authors.affiliation: Medical Department, 3M Company, St. Paul, MN 55144 United States. Electronic address: jlbutenhoff@mmm.com.
authors.forename: John L
authors.initials: JL
authors.lastname: Butenhoff
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004785:Environmental Pollutants / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D005243:Feces / Q000737:chemistry; D005260:Female; D005466:Fluorocarbons; D006207:Half-Life; D007275:Injections, Intravenous; D008099:Liver / Q000378:metabolism; D008252:Macaca fascicularis; D008297:Male; D008657:Metabolic Clearance Rate; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D017207:Rats, Sprague-Dawley; D012737:Sex Factors; D013045:Species Specificity; D013451:Sulfonic Acids / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D014018:Tissue Distribution
chemical_list: D004785:Environmental Pollutants; D005466:Fluorocarbons; D013451:Sulfonic Acids; C471071:perfluorohexanesulfonic acid