title: Antidepressant-like effect of riparin II from Aniba riparia in mice: evidence for the involvement of the monoaminergic system.
abstract: In a previous study conducted by our group, riparin II (ripII) isolated from the green fruit of Aniba riparia presented antianxiety effects in mice. This study investigates a possible antidepressant activity of rip II using two predictive tests for antidepressant activity in rodents: the forced swimming test (FST) and tail suspension test (TST). Additionally, the mechanisms involved in the antidepressant-like effect in mice were also assessed. Rip II was acute administered by intraperitoneal (i.p.) and oral (p.o) routes to male mice at doses of 25 and 50 mg/kg. Results showed that ripII at both tested doses and administration routes produced a significant decrease of immobility time in FST and TST. The pretreatment of mice with prazosin (1 mg/kg, i.p., an α1-adrenoceptor antagonist), SCH23390 (15 μg/kg, i.p., a dopamine D1 receptor antagonist), sulpiride (50 mg/kg, i.p., a dopamine D2 receptor antagonist), p-chlorophenylalanine (100 mg/kg, an inhibitor of serotonin synthesis), or NAN-190 (0.5 mg/kg, a serotonin 5-HT1A receptor antagonist) completely blocked the anti-immobility effects elicited by riparin II (50 mg/kg, p.o.) in the FST. This study indicates that riparin II produces significant antidepressant-like activity in the forced swimming and TSTs, and this effect seems to be dependent on its interaction with noradrenergic, dopaminergic, and serotonergic systems.
authors.affiliation: Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará: Rua Cel. Nunes de Melo 1127, 60430-270 Fortaleza, Brazil.
authors.forename: Caroline Porto Leite
authors.initials: CP
authors.lastname: Teixeira
authors.forename: Carla Thiciane Vasconcelos
authors.initials: CT
authors.lastname: de Melo
authors.forename: Fernando Luiz Oliveira
authors.initials: FL
authors.lastname: de Araújo
authors.forename: Allyne Mara Rodrigues
authors.initials: AM
authors.lastname: de Carvalho
authors.forename: Maria Izabel Gomes
authors.initials: MI
authors.lastname: Silva
authors.forename: José Maria
authors.initials: JM
authors.lastname: Barbosa-Filho
authors.forename: Danielle Silveira
authors.initials: DS
authors.lastname: Macêdo
authors.forename: Glauce Socorro
authors.initials: GS
authors.lastname: de Barros Viana
authors.forename: Francisca Cléa Florenço
authors.initials: FC
authors.lastname: de Sousa
mesh_terms: D059331:Adrenergic Neurons / Q000187:drug effects*; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D001549:Benzamides / Q000494:pharmacology*; D015259:Dopamine Agents / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D019417:Hindlimb Suspension; D046353:Immobility Response, Tonic / Q000187:drug effects; D019770:Lauraceae / Q000737:chemistry; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D018490:Serotonin Agents / Q000494:pharmacology*; D013550:Swimming; D014439:Tyramine / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000928:Antidepressive Agents; D001549:Benzamides; D015259:Dopamine Agents; C521850:N-(2-hydroxybenzoyl)tyramine; D018490:Serotonin Agents; D014439:Tyramine