title: Hangover sensitivity after controlled alcohol administration as predictor of post-college drinking.
abstract: Predicting continued problematic levels of drinking after the early 20's could help with early identification of persons at risk. This study investigated whether hangover insensitivity could predict postcollege drinking and problems beyond the variance due to drinking patterns. In a preliminary study, 134 college seniors from a laboratory study of hangover (Time 1) were contacted and assessed 1-4 years (M = 2.3) later (Time 2). Hangover severity was studied after controlled alcohol administration to a specific dose while controlling sleep and environmental influences. Hangover severity at Time 1 was used to predict Time 2 drinking volume and problems while controlling for relevant demographics and Time 1 drinking volume. Hangover insensitivity at Time 1 tended to predict a clinical level of alcohol problems with a large statistical effect size. Hangover sensitivity also correlated positively with sensitivity to alcohol intoxication. Hangover severity did not predict future drinking volume. Hangover insensitivity correlates with insensitivity to intoxication and might predict more serious alcohol problems in the future, suggesting that a future larger study is warranted. Hangover insensitivity could result from physiological factors underlying low sensitivity to alcohol or risk for alcoholism.
authors.affiliation: Center for Alcohol and Addiction Studies, Brown University Box G-S121-5, Providence, RI 02912, USA. Damaris_Rohsenow@brown.edu
authors.forename: Damaris J
authors.initials: DJ
authors.lastname: Rohsenow
authors.forename: Jonathan
authors.initials: J
authors.lastname: Howland
authors.forename: Michael
authors.initials: M
authors.lastname: Winter
authors.forename: Caleb A
authors.initials: CA
authors.lastname: Bliss
authors.forename: Caroline A
authors.initials: CA
authors.lastname: Littlefield
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Heeren
authors.forename: Tamara V
authors.initials: TV
authors.lastname: Calise
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects* / Q000453:epidemiology*; D019973:Alcohol-Related Disorders / Q000453:epidemiology*; D000431:Ethanol / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D013334:Students; D055815:Young Adult
chemical_list: D000431:Ethanol