title: Most recent developments and modifications of 14-alkylamino and 14-alkoxy-4,5-epoxymorphinan derivatives.
abstract: The 14-position of natural opiates (e.g. morphine) are unsubstituted, however synthetic approaches have uncovered that functionalizing position 14 gives rise to a wide range of diverse activities. This review focuses on SAR of the position, with the aim of aiding in the search for opioid analgesics with improved clinical profiles.
authors.affiliation: Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.
authors.forename: L
authors.initials: L
authors.lastname: Stavitskaya
authors.forename: A
authors.initials: A
authors.lastname: Coop
mesh_terms: D000818:Animals; D006801:Humans; D009019:Morphinans / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D009292:Narcotic Antagonists; D010146:Pain / Q000188:drug therapy*; D011957:Receptors, Opioid / Q000819:agonists*; D013329:Structure-Activity Relationship
chemical_list: C496139:4,5-epoxymorphinan; D009019:Morphinans; D009292:Narcotic Antagonists; D011957:Receptors, Opioid