title: Spatial distribution of corneal light scattering after corneal collagen crosslinking.
abstract: OBJECTIVE
  To assess the spatial distribution and time course of increased corneal light scattering after corneal collagen crosslinking (CXL) with riboflavin and ultraviolet-A irradiation.
  
  
  METHODS
  Umeå University Hospital Eye Clinic, Umeå, Sweden.
  
  
  METHODS
  Case series.
  
  
  METHODS
  Eyes with keratoconus were examined with Scheimpflug photography before and 1 and 6 months after CXL. Corneal light scattering was quantified throughout the corneal thickness at 8 measurement points 0.0 to 3.0 mm from the central cornea.
  
  
  RESULTS
  The study comprised 11 eyes of 11 patients. Central corneal light scattering increased significantly 1 month after CXL (P<.001). At 6 months, it decreased (P = .002); however, it was still higher than pretreatment values (P<.001). Light scattering at 1 month was more pronounced in the superficial stroma, gradually diminishing to zero at 240 μm depth. It was greater at the corneal center than 1.0 to 3.0 mm from the center. At 6 months, a second peak of light scattering occurred between 240 μm and 340 μm depth. No increased light scattering deeper than 340 μm was seen at either time point.
  
  
  CONCLUSIONS
  Corneal light scattering after CXL showed distinctive spatial and temporal profiles. Analysis of corneal light scattering may give an impression of tissue changes, the depth of the CXL treatment effect, and the corneal response to the treatment. Scheimpflug photography appears to be useful for this purpose.
  
  
  BACKGROUND
  No author has a financial or proprietary interest in any material or method mentioned.
authors.affiliation: Department of Clinical Sciences/Ophthalmology, Umeå University, Umeå, Sweden.
authors.forename: Jeannette
authors.initials: J
authors.lastname: Beckman Rehnman
authors.forename: Chris C
authors.initials: CC
authors.lastname: Janbaz
authors.forename: Anders
authors.initials: A
authors.lastname: Behndig
authors.forename: Christina
authors.initials: C
authors.lastname: Lindén
mesh_terms: D000328:Adult; D003094:Collagen / Q000378:metabolism*; D003315:Cornea / Q000528:radiation effects*; D003319:Corneal Stroma / Q000378:metabolism*; D003432:Cross-Linking Reagents / Q000627:therapeutic use*; D006801:Humans; D007640:Keratoconus / Q000188:drug therapy* / Q000378:metabolism; D008027:Light; D008297:Male; D010778:Photochemotherapy; D010781:Photography; D017319:Photosensitizing Agents / Q000627:therapeutic use; D011446:Prospective Studies; D012256:Riboflavin / Q000627:therapeutic use; D012542:Scattering, Radiation; D055815:Young Adult
chemical_list: D003432:Cross-Linking Reagents; D017319:Photosensitizing Agents; D003094:Collagen; D012256:Riboflavin