title: In vitro and in vivo anticancer activity of (+)-spongistatin 1.
abstract: The marine natural product (+)-spongistatin 1 is an extremely potent growth inhibitory agent having activity against a wide variety of cancer cell lines, while exhibiting low cytotoxicity against quiescent human fibroblasts. Consistent with a microtubule-targeting mechanism of action, (+)-spongistatin 1 causes mitotic arrest in DU145 human prostate cancer cells. More importantly, (+)-spongistatin 1 exhibits significant in vivo antitumor activity in the LOX-IMVI human melanoma xenograft model. (+)-Spongistatin 1 is, thus, an important class of microtubule targeting anticancer agent that warrants further investigation.
authors.affiliation: Eisai Inc., 4 Corporate Drive, Andover, MA 01810, USA. qunli_xu@eisai.com
authors.forename: Qunli
authors.initials: Q
authors.lastname: Xu
authors.forename: Kuan-Chun
authors.initials: KC
authors.lastname: Huang
authors.forename: Karen
authors.initials: K
authors.lastname: Tendyke
authors.forename: Joanne
authors.initials: J
authors.lastname: Marsh
authors.forename: Junke
authors.initials: J
authors.lastname: Liu
authors.forename: Dayong
authors.initials: D
authors.lastname: Qiu
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Littlefield
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nomoto
authors.forename: Onur
authors.initials: O
authors.lastname: Atasoylu
authors.forename: Christina A
authors.initials: CA
authors.lastname: Risatti
authors.forename: Jeffrey B
authors.initials: JB
authors.lastname: Sperry
authors.forename: Amos B
authors.initials: AB
authors.lastname: Smith
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D000818:Animals; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D066298:In Vitro Techniques; D018942:Macrolides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D051379:Mice; D008856:Microscopy, Fluorescence; D013237:Stereoisomerism; D050257:Tubulin Modulators / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000095702:Polyether Toxins
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D018942:Macrolides; D050257:Tubulin Modulators; C083856:spongistatin 1; D000095702:Polyether Toxins