title: Systematic review of pancreaticoduodenectomy for locally advanced gastric cancer.
abstract: BACKGROUND
  The purpose of this study was to identify and synthesize findings from all articles on surgical and long-term outcomes in patients with gastric cancer undergoing gastrectomy combined with pancreaticoduodenectomy (PD).
  
  
  METHODS
  Electronic literature searches were conducted using Medline, EMBASE, and Cochrane databases from January 1, 1985, to December 31, 2009.
  
  
  RESULTS
  Eight retrospective case series were included, with 132 patients having PD combined with gastrectomy. PD was combined with total gastrectomy in 27 patients, and subtotal gastrectomy in 81 patients; 24 patients had undocumented gastric resection type. Clinical stage was available for 92 patients (4 stage I, 7 stage II, 26 stage III, and 55 stage IV). Five studies (98 patients having PD combined with gastrectomy) compared PD and gastrectomy to gastrectomy alone. In the four studies reporting morbidity, PD had a higher morbidity. The pooled pancreatic anastomotic leak rate was 24.5% for the seven studies in which complications were reported; however, there were no peri-operative deaths. Long-term survival (37.3% at 5 years) in gastric cancer patients with PD combined with gastrectomy was described; however, survival was poor in the setting of incurable factors. Due to heterogeneity of patients and staging techniques in the case series no recommendations can be made on the appropriate selection criteria for patients undergoing PD and gastrectomy.
  
  
  CONCLUSIONS
  PD for gastric cancer invading the pancreas is associated with a higher morbidity; given the heterogeneous data, defining exact selection criteria is difficult.
authors.affiliation: Division of General Surgery, University of Toronto, Toronto, Canada.
authors.forename: Patrick
authors.initials: P
authors.lastname: Roberts
authors.forename: Rajini
authors.initials: R
authors.lastname: Seevaratnam
authors.forename: Roberta
authors.initials: R
authors.lastname: Cardoso
authors.forename: Calvin
authors.initials: C
authors.lastname: Law
authors.forename: Lucy
authors.initials: L
authors.lastname: Helyer
authors.forename: Natalie
authors.initials: N
authors.lastname: Coburn
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods; D005743:Gastrectomy / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D009367:Neoplasm Staging; D016577:Pancreaticoduodenectomy / Q000009:adverse effects / Q000379:methods*; D018579:Patient Selection; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery*; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome