title: Synthesis of the ABH rings of ecteinascidin 597 using a connective Pummerer-type cyclisation.
abstract: A connective Pummerer-type cyclisation involving a cysteine derivative and an N-benzyl glyoxamide 3 has been applied in an asymmetric synthesis of the protected ABH rings 2 of the antitumour and antimicrobial natural product ecteinascidin 597.
authors.affiliation: School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
authors.forename: Laura H S
authors.initials: LH
authors.lastname: Smith
authors.forename: Trung Thanh
authors.initials: TT
authors.lastname: Nguyen
authors.forename: Helen F
authors.initials: HF
authors.lastname: Sneddon
authors.forename: David J
authors.initials: DJ
authors.lastname: Procter
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D003545:Cysteine / Q000737:chemistry; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry; D013453:Sulfonylurea Compounds / Q000737:chemistry; D014561:Urochordata / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D007546:Isoquinolines; D013438:Sulfhydryl Compounds; D013453:Sulfonylurea Compounds; C517484:ecteinascidin 597; C032160:glyoxamide; D003545:Cysteine