title: Fatal diffuse alveolar damage associated with oxaliplatin administration.
abstract: Oxaliplatin-based chemotherapy regimens are currently a standard of care for the treatment of colorectal cancer in both the adjuvant and metastatic disease settings. Significant improvements in survival have resulted from the use of oxaliplatin-based combinations. This article describes the use of oxaliplatin-based chemotherapy in a patient with stage III colon cancer who developed fatal diffuse alveolar damage during his adjuvant therapy. Other cases of pulmonary toxicity associated with oxaliplatin use are presented and the proposed pathophysiology of this rare occurrence is discussed.
authors.affiliation: Division of Pharmacy, The University of Texas MD Anderson Cancer Center, Houston, USA.
authors.forename: Jack
authors.initials: J
authors.lastname: Watkins
authors.forename: Julian H
authors.initials: JH
authors.lastname: Slade
authors.forename: Alex
authors.initials: A
authors.lastname: Phan
authors.forename: Cathy
authors.initials: C
authors.lastname: Eng
authors.forename: Annikka
authors.initials: A
authors.lastname: Weissferdt
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Overman
mesh_terms: D055371:Acute Lung Injury / Q000139:chemically induced*; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D003110:Colonic Neoplasms / Q000188:drug therapy*; D017809:Fatal Outcome; D005472:Fluorouracil / Q000009:adverse effects; D006801:Humans; D002955:Leucovorin / Q000009:adverse effects; D008297:Male; D009944:Organoplatinum Compounds / Q000009:adverse effects; D011650:Pulmonary Alveoli / Q000187:drug effects* / Q000473:pathology*; D012131:Respiratory Insufficiency / Q000139:chemically induced*
chemical_list: D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil