title: Hepatoprotective and Antioxidative Activities of Cornus officinalis against Acetaminophen-Induced Hepatotoxicity in Mice.
abstract: The fruit of Cornus officinalis Sieb. et Zucc. is commonly prescribed in Asian countries as a tonic formula. In this study, the hepatoprotective effect of ethanolic extracts of the fruit of C. officinalis (ECO) was investigated in a mouse model of acetaminophen- (APAP-) induced liver injury. Pretreatment of mice with ECO (100, 250, and 500 mg/kg for 7 days) significantly prevented the APAP (200 mg/kg) induced hepatic damage as indicated by the serum marker enzymes (AST, ALT, and LDH). Parallel to these changes, ECO treatment also prevented APAP-induced oxidative stress in the mice liver by inhibiting lipid peroxidation (MDA) and restoring the levels of antioxidant enzymes (SOD, CAT, and HO-1) and glutathione. Liver injury and collagen accumulation were assessed using histological studies by hematoxylin and eosin staining. Our results indicate that ECO can prevent hepatic injuries associated with APAP-induced hepatotoxicity by preventing or alleviating oxidative stress.
authors.affiliation: Herbal Medicine EBM Research Center, Korea Institute of Oriental Medicine, 483, Exporo, Yuseong-gu, Daejeon 305-811, Republic of Korea.
authors.forename: Nam-Hun
authors.initials: NH
authors.lastname: Lee
authors.forename: Chang-Seob
authors.initials: CS
authors.lastname: Seo
authors.forename: Ho-Young
authors.initials: HY
authors.lastname: Lee
authors.forename: Da-Young
authors.initials: DY
authors.lastname: Jung
authors.forename: Jun-Kyung
authors.initials: JK
authors.lastname: Lee
authors.forename: Jin-Ah
authors.initials: JA
authors.lastname: Lee
authors.forename: Kye Yong
authors.initials: KY
authors.lastname: Song
authors.forename: Hyeun-Kyoo
authors.initials: HK
authors.lastname: Shin
authors.forename: Mee-Young
authors.initials: MY
authors.lastname: Lee
authors.forename: Young Bae
authors.initials: YB
authors.lastname: Seo
authors.forename: Hokyoung
authors.initials: H
authors.lastname: Kim
authors.forename: Hyekyung
authors.initials: H
authors.lastname: Ha