title: Atherosclerosis and PTPN22: a study in coronary artery disease.
abstract: OBJECTIVE
  Recently, it has been shown that PTPN22 genetic polymorphism is associated with phenotypes related to the risk of atherosclerosis. In the present note, we have searched for a possible association of PTPN22 polymorphism with coronary artery disease (CAD).
  
  
  METHODS
  One hundred and thirty-four non-diabetic subjects admitted to hospital for CAD and 174 healthy subjects (blood donors) were studied. PTPN22 genotypes were determined by DNA analysis. Statistical analyses were performed by SPSS programs.
  
  
  RESULTS
  In CAD patients, the proportion of carriers of the *T allele of PTPN22 is significantly higher compared to healthy controls (OR 2.66; 95% CI 1.07-6.72).
  
  
  CONCLUSIONS
  The present observation confirms the association of PTPN22 phenotype with atherosclerosis and suggests a role of immune mechanism in the pathogenesis of CAD.
authors.affiliation: Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Rome, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Saccucci
authors.forename: M
authors.initials: M
authors.lastname: Banci
authors.forename: E
authors.initials: E
authors.lastname: Cozzoli
authors.forename: A
authors.initials: A
authors.lastname: Neri
authors.forename: A
authors.initials: A
authors.lastname: Magrini
authors.forename: E
authors.initials: E
authors.lastname: Bottini
authors.forename: F
authors.initials: F
authors.lastname: Gloria-Bottini
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22 / Q000235:genetics*
chemical_list: C516765:PTPN22 protein, human; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22