title: The future of cell culture-based influenza vaccine production.
abstract: Influenza vaccines have been prepared in embryonated chicken eggs and used for more than 60 years. Although this older technology is adequate to produce hundreds of millions of doses per year, most viral vaccines are now being produced in cell culture platforms. The question of whether egg-based influenza vaccines will continue to serve the needs of the growing influenza vaccine market is considered here. In 2006, the US government committed to support the development of cell-based influenza vaccines by funding advanced development and expansion of domestic manufacturing infrastructure. Funding has also been provided for other recombinant DNA approaches that do not depend on growth of influenza viruses. As the influenza vaccine industry expands over the next 5-10 years, it will be interesting to follow which of these various technologies are able to best meet the needs of a growing influenza vaccine market.
authors.affiliation: Biomedical Advanced Research and Development Authority (BARDA), Department of Health and Human Services, Influenza Division, 330 Independence Avenue, SW RM G640, Washington DC, USA. michael.perdue@hhs.gov
authors.forename: Michael L
authors.initials: ML
authors.lastname: Perdue
authors.forename: Frank
authors.initials: F
authors.lastname: Arnold
authors.forename: Sheng
authors.initials: S
authors.lastname: Li
authors.forename: Armen
authors.initials: A
authors.lastname: Donabedian
authors.forename: Vittoria
authors.initials: V
authors.lastname: Cioce
authors.forename: Thomas
authors.initials: T
authors.lastname: Warf
authors.forename: Robert
authors.initials: R
authors.lastname: Huebner
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques / Q000191:economics / Q000379:methods*; D006801:Humans; D007252:Influenza Vaccines / Q000096:biosynthesis* / Q000191:economics / Q000276:immunology; D009975:Orthomyxoviridae / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000096:biosynthesis / Q000191:economics / Q000276:immunology; D014614:Vaccines, Synthetic / Q000096:biosynthesis / Q000191:economics / Q000276:immunology
chemical_list: D007252:Influenza Vaccines; D014613:Vaccines, Attenuated; D014614:Vaccines, Synthetic