title: CD86 +1057G/A polymorphism and susceptibility to Ewing's sarcoma: a case-control study.
abstract: The development of Ewing's sarcoma (ES) is a complex process resulting from interplay between mutations in oncogenes and tumor suppressors, host susceptibility factors, and cellular context. CD86 (B7-2) may affect cancer susceptibility by modulating T cell response. CD86 +1057G/A polymorphism (rs1129055) has been reported to be associated with various diseases. Here, we investigated the association between CD86 +1057G/A polymorphism and the risk of ES in a Chinese population. The CD86 +1057G/A polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism in 158 ES cases and 212 age-matched healthy controls. Frequencies of CD86 +1057 AA genotype and +1057 A allele were significantly increased in patients with ES compared to healthy controls (odds ratio [OR]=2.12, 95% confidence interval [CI], 1.11-3.79, p=0.021; and OR=1.41, 95% CI, 1.10-1.91, p=0.018). Our data suggest that the +1057G/A polymorphism of the CD86 gene is associated with increased susceptibility to ES.
authors.affiliation: Department of Orthopedics, Shanghai Corps Hospital, Chinese People's Armed Police Forces, Changning, Shanghai, China. jianwang1962@126.com
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Yujia
authors.initials: Y
authors.lastname: Zhou
authors.forename: Dapeng
authors.initials: D
authors.lastname: Feng
authors.forename: Haitao
authors.initials: H
authors.lastname: Yang
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.forename: Qianlai
authors.initials: Q
authors.lastname: Cao
authors.forename: An
authors.initials: A
authors.lastname: Wang
authors.forename: Fei
authors.initials: F
authors.lastname: Xing
mesh_terms: D051940:B7-2 Antigen / Q000235:genetics*; D001859:Bone Neoplasms / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012512:Sarcoma, Ewing / Q000453:epidemiology / Q000235:genetics*
chemical_list: D051940:B7-2 Antigen; C497964:CD86 protein, human