title: Genetic mouse models relevant to schizophrenia: taking stock and looking forward.
abstract: Genetic mouse models relevant to schizophrenia complement, and have to a large extent supplanted, pharmacological and lesion-based rat models. The main attraction is that they potentially have greater construct validity; however, they share the fundamental limitations of all animal models of psychiatric disorder, and must also be viewed in the context of the uncertain and complex genetic architecture of psychosis. Some of the key issues, including the choice of gene to target, the manner of its manipulation, gene-gene and gene-environment interactions, and phenotypic characterization, are briefly considered in this commentary, illustrated by the relevant papers reported in this special issue.
authors.affiliation: Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK. paul.harrison@psych.ox.ac.uk
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Harrison
authors.forename: David
authors.initials: D
authors.lastname: Pritchett
authors.forename: Katharina
authors.initials: K
authors.lastname: Stumpenhorst
authors.forename: Jill F
authors.initials: JF
authors.lastname: Betts
authors.forename: Wiebke
authors.initials: W
authors.lastname: Nissen
authors.forename: Judith
authors.initials: J
authors.lastname: Schweimer
authors.forename: Tracy
authors.initials: T
authors.lastname: Lane
authors.forename: Philip W J
authors.initials: PW
authors.lastname: Burnet
authors.forename: Karri P
authors.initials: KP
authors.lastname: Lamsa
authors.forename: Trevor
authors.initials: T
authors.lastname: Sharp
authors.forename: David M
authors.initials: DM
authors.lastname: Bannerman
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Tunbridge
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D006801:Humans; D051379:Mice; D012559:Schizophrenia / Q000209:etiology / Q000235:genetics*