title: [Inhalation of aerosolized perfluorocarbon combined with tetramethylpyrazine ameliorates hemodynamics and pulmonary histopathology in a porcine model of acute lung injury].
abstract: OBJECTIVE
  To observe the effect of inhalation of aerosolized perfluorocarbon combined with tetramethylpyrazine on the hemodynamics and histopathology in a porcine model of acute lung injury.
  
  
  METHODS
  Normal adult pigs were subjected to saline lavage of the bilateral lungs to induce acute lung injury and randomized subsequently into 3 groups for treatment with inhalation of perfluorocarbon, combined inhalation of perfluorocarbon and tetramethylpyrazine, or inhalation of tetramethylpyrazine. The changes of mean arterial pressure (MAP), PetCO(2), mPAP, CVP and PAWP were recorded at different time points following the lung injury, and the lung tissues were sampled for histological observations.
  
  
  RESULTS
  The MAP, mPAP, CVP and PAWP all increased significantly in the 3 groups after acute lung injury. Interventions with combined tetramethylpyrazine and perfluorocarbon inhalation significantly improved these indices as compared with inhalation of tetramethylpyrazine or perfluorocarbon alone (P<0.05). The pulmonary pathology was the mildest in the combined inhalation group, and the most severe in tetramethylpyrazine group.
  
  
  CONCLUSIONS
  Combined inhalation of perfluorocarbon and tetramethylpyrazine can effectively improve the oxygenation, reduce pulmonary arterial pressure?and ameliorate lung pathology in pigs with acute lung injury.
authors.affiliation: Department of Anesthesia, First Affiliated Hospital of Jinan University, Guangzhou, China.
authors.forename: Xue-mei
authors.initials: XM
authors.lastname: Peng
authors.forename: Juan-hua
authors.initials: JH
authors.lastname: Xie
authors.forename: Bing
authors.initials: B
authors.lastname: Shuai
authors.forename: Yan-lan
authors.initials: YL
authors.lastname: Li
authors.forename: Zhong-hong
authors.initials: ZH
authors.lastname: Wang
authors.forename: Hua-dong
authors.initials: HD
authors.lastname: Wang
authors.forename: Yan-ping
authors.initials: YP
authors.lastname: Wang
mesh_terms: D055371:Acute Lung Injury / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D000280:Administration, Inhalation; D000818:Animals; D004359:Drug Therapy, Combination; D005466:Fluorocarbons / Q000008:administration & dosage*; D006439:Hemodynamics / Q000187:drug effects*; D008168:Lung / Q000473:pathology*; D008517:Phytotherapy; D011719:Pyrazines / Q000008:administration & dosage*; D013552:Swine
chemical_list: D005466:Fluorocarbons; D011719:Pyrazines; C017953:tetramethylpyrazine