title: Laser ablation of placental vessels in twin-to-twin transfusion syndrome: a paradigm for endoscopic fetal surgery.
abstract: Endoscopic fetal surgery is most commonly used for the treatment of twin-to-twin transfusion syndrome (TTTS), but the surgical techniques can be applied to other forms of fetal surgery. We present our experience with endoscopic fetal surgery over the past 10 years. From 2000 to 2010, 70 endoscopic laser ablations of placental vessels for TTTS were performed. Median number of placental vessels ablated was four. The incidence of preterm rupture of membranes (PROM) was 6%. Overall survival was 70%, with at least one twin surviving in 82%. Tocolysis was used in 73% of patients for a median of 12 hours. The combination of an open surgical approach, Seldinger technique, and uterine plugging led to outcomes similar to other reports, with a significantly lower PROM rate. Although TTTS is the most common application of endoscopic fetal surgery, this approach is applicable for other indications. Insertion and removal of tracheal occlusion balloons for severe congenital diaphragmatic hernia are currently being performed at our institution.
authors.affiliation: Division of Pediatric Surgery, Alpert Medical School of Brown University, Providence, Rhode Island, USA.
authors.forename: Michele L
authors.initials: ML
authors.lastname: Lombardo
authors.forename: Debra J
authors.initials: DJ
authors.lastname: Watson-Smith
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Muratore
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Carr
authors.forename: Barbara M
authors.initials: BM
authors.lastname: O'Brien
authors.forename: François I
authors.initials: FI
authors.lastname: Luks
mesh_terms: D005260:Female; D005313:Fetal Death / Q000209:etiology; D005322:Premature Rupture of Fetal Membranes / Q000209:etiology; D005330:Fetofetal Transfusion / Q000601:surgery*; D005332:Fetoscopy / Q000379:methods*; D005333:Fetus / Q000601:surgery; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D010920:Placenta / Q000098:blood supply*; D011247:Pregnancy