title: Therapeutic plasma exchange in amitriptyline intoxication: case report and review of the literature.
abstract: Severe amitriptyline poisoning results in cardiac and neurological toxicity and continues to be a leading cause of significant morbidity and mortality both in children and adults. We present a case of severe amitriptyline poisoning successfully treated with plasma exchange. Due to high plasma protein binding property of amitriptyline, plasma exchange therapy should be considered in cases of severe amitriptyline intoxication as a life saving therapeutic modality.
authors.affiliation: Pamukkale University, Faculty of Medicine, Department of Hematology, Therapeutic Apheresis Unit, Denizli, Turkey. hisari@gmail.com
authors.forename: Ismail
authors.initials: I
authors.lastname: Sari
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Turkcuer
authors.forename: Tuba
authors.initials: T
authors.lastname: Erurker
authors.forename: Mustafa
authors.initials: M
authors.lastname: Serinken
authors.forename: Murat
authors.initials: M
authors.lastname: Seyit
authors.forename: Ali
authors.initials: A
authors.lastname: Keskin
mesh_terms: D000293:Adolescent; D000328:Adult; D000639:Amitriptyline / Q000506:poisoning*; D000929:Antidepressive Agents, Tricyclic / Q000506:poisoning*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D010951:Plasma Exchange / Q000379:methods*; D010956:Plasmapheresis; D055815:Young Adult
chemical_list: D000929:Antidepressive Agents, Tricyclic; D000639:Amitriptyline