title: Anatomic and electro-physiologic connectivity of the language system: a combined DTI-CCEP study.
abstract: Here we present a novel multimodal analysis of network connectivity in the language system. We assessed connectivity of Broca's area using tractography with diffusion tensor imaging (DTI), and with cortico-cortical evoked potentials (CCEPs) to measure the spread of artificial currents applied directly to human cortex. We found that both the amplitude and latency of CCEP currents significantly correlates (r(2)=0.41, p<10(-16)) with the number of DTI pathways connecting the stimulation and recording loci. This strategy of relating electrical information flow with the neural architecture will likely yield new insights into cognitive processes.
authors.affiliation: Vivian L. Smith Department of Neurosurgery, University of Texas Medical School at Houston, USA.
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Conner
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Ellmore
authors.forename: Michael A
authors.initials: MA
authors.lastname: DiSano
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Pieters
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Potter
authors.forename: Nitin
authors.initials: N
authors.lastname: Tandon
mesh_terms: D000328:Adult; D056324:Diffusion Tensor Imaging / Q000295:instrumentation / Q000379:methods*; D004567:Electrodes, Implanted; D004827:Epilepsy / Q000503:physiopathology / Q000601:surgery; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D005625:Frontal Lobe / Q000033:anatomy & histology / Q000502:physiology*; D006801:Humans; D007802:Language; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000502:physiology; D012044:Regression Analysis