title: Cu(II)-catalyzed intermolecular amidation of C-acylimine: a convenient access to gem-diamino acid derivatives.
abstract: C-Acylimines 1 undergo intermolecular amidation with amides 2 to produce monoacyl gem-diamino acid derivatives 3 upon treatment with Cu(OTf)(2) (20 mol%)/ PPh(3) (20 mol%) under mild conditions. This method provides an efficient access to gem-diamino acid equivalents with good to excellent yields.
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, No. 381, Wushan Road, Tianhe District, Guangzhou, PR China 510641.
authors.forename: Shujie
authors.initials: S
authors.lastname: Zhu
authors.forename: Jia
authors.initials: J
authors.lastname: Dong
authors.forename: Shaomin
authors.initials: S
authors.lastname: Fu
authors.forename: Huanfeng
authors.initials: H
authors.lastname: Jiang
authors.forename: Wei
authors.initials: W
authors.lastname: Zeng
mesh_terms: D000577:Amides / Q000737:chemistry*; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000577:Amides; D000596:Amino Acids; D007097:Imines; D009942:Organometallic Compounds; D003300:Copper