title: Comparison of bioassays with different exposure time patterns: the added value of dynamic modelling in predictive ecotoxicology.
abstract: The purpose of this study was to compare Daphnia magna responses to cadmium between two toxicity experiments performed in static and flow-through conditions. As a consequence of how water was renewed, the two experiments were characterised by two different exposure time patterns for daphnids, time-varying and constant, respectively. Basing on survival, growth and reproduction, we addressed the questions of organism development and sensitivity to cadmium. Classical analysis methods are not designed to deal with the time dimension and therefore not suitable to compare effects of different exposure time patterns. We used instead a dynamic modelling framework taking all timepoints and the time course of exposure into account, making comparable the results obtained from our two experiments. This modelling framework enabled us to detect an improvement of organism development in flow-through conditions compared to static ones and infer similar sensitivity to cadmium for both exposure time patterns.
authors: Pôle de Recherche ROVALTAIN en Toxicologie Environnementale et Ecotoxicologie, Valence Cedex 9, France. elise.billoir@univ-lyon1.fr
authors: Elise
authors: E
authors: Billoir
authors: Hèlène
authors: H
authors: Delhaye
authors: Carole
authors: C
authors: Forfait
authors: Bernard
authors: B
authors: Clément
authors: Gaëlle
authors: G
authors: Triffault-Bouchet
authors: Sandrine
authors: S
authors: Charles
authors: Marie Laure
authors: ML
authors: Delignette-Muller
mesh_terms: D000818:Animals; D001681:Biological Assay / Q000379:methods*; D002104:Cadmium / Q000633:toxicity; D003621:Daphnia / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D054750:Ecotoxicology; D008954:Models, Biological; D012098:Reproduction / Q000187:drug effects; D012680:Sensitivity and Specificity; D014874:Water Pollutants, Chemical / Q000633:toxicity
chemical_list: D014874:Water Pollutants, Chemical; D002104:Cadmium