title: Atorvastatin ameliorates experimental autoimmune neuritis by decreased Th1/Th17 cytokines and up-regulated T regulatory cells.
abstract: Statins have anti-inflammatory and immune-regulating properties. To investigate the effects of atorvastatin on experimental autoimmune neuritis (EAN), an animal model of Guillain-Barré syndrome (GBS), atorvastatin was administered to Lewis rats immunized with bovine peripheral myelin in complete Freund's adjuvant. We found that atorvastatin ameliorated the clinical symptoms of EAN, decreased the numbers of inflammatory cells as well as IFN-γ(+) and IL-17(+) cells in sciatic nerves, decreased the CD80 expression and increased the number of CD25(+)Foxp3(+) cells in mononuclear cells (MNC), and decreased the levels of IFN-γ in MNC culture supernatants. These data provide strong evidence that atorvastatin can act as an inhibitor in EAN by inhibiting the immune response of Th1 and Th17, decreasing the expression of co-stimulatory molecule, and up-regulating the number of T regulatory cells. These data demonstrated that statins could be used as a therapeutic strategy in human GBS in future.
authors: Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, PR China.
authors: Xiao-Li
authors: XL
authors: Li
authors: Ying-Chun
authors: YC
authors: Dou
authors: Ying
authors: Y
authors: Liu
authors: Chang-Wen
authors: CW
authors: Shi
authors: Li-Li
authors: LL
authors: Cao
authors: Xiu-Qing
authors: XQ
authors: Zhang
authors: Jie
authors: J
authors: Zhu
authors: Rui-Sheng
authors: RS
authors: Duan
mesh_terms: D000818:Animals; D000069059:Atorvastatin; D002417:Cattle; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D020275:Guillain-Barre Syndrome / Q000188:drug therapy / Q000276:immunology; D006538:Heptanoic Acids / Q000494:pharmacology*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D007114:Immunization; D007371:Interferon-gamma / Q000378:metabolism; D020381:Interleukin-17 / Q000378:metabolism; D009186:Myelin Sheath / Q000276:immunology; D009444:Neuritis, Autoimmune, Experimental / Q000188:drug therapy* / Q000276:immunology* / Q000473:pathology; D011758:Pyrroles / Q000494:pharmacology*; D051381:Rats; D011917:Rats, Inbred Lew; D012584:Sciatic Nerve / Q000187:drug effects / Q000473:pathology; D016176:T-Lymphocyte Subsets / Q000187:drug effects* / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology; D018417:Th1 Cells / Q000187:drug effects / Q000276:immunology; D058504:Th17 Cells / Q000187:drug effects / Q000276:immunology
chemical_list: D016207:Cytokines; D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D020381:Interleukin-17; D011758:Pyrroles; D007371:Interferon-gamma; D000069059:Atorvastatin