title: [Changes of MMP-9 and TIMP-1 levels in gingival crevicular fluid during orthodontic tooth movement under orthodontic forces].
abstract: OBJECTIVE
  To investigate the dynamic changes of MMP-9 and TIMP-1 levels in gingival crevicular fluid during orthodontic tooth movement under orthodontic forces.
  
  
  METHODS
  select 20 cases which fit experiment condition. The cases divided randomly into 2 groups, 1- cases for each group. The distal forces of 100g and 250 g were exerted to the canine on the one side of two groups separately. The GCF were taken before activation and at 1, 2, 3, 4, 5, 6, 7 week respectively after initiation of the experiment. The levels of MMP-9 and TIMP-1 in GCF were determined by ELISA.
  
  
  RESULTS
  The levels of MMP-9 in A group began to increase at 1 week and reached to its peak value at 3 week after initiation of the experiment, but the level returned to baseline at 7 week. The levels of TIMP-1 in A group began to increase at 1, 2, 3 week and decreased at 4 week after initiation of the experiment, but the level at 6,7 week was higher than that before initiation of the experiment. The level of MMP-9 in A group was higher than that in B group at all times and the level of TIMP-1 in A group was lower than that in B group.
  
  
  CONCLUSIONS
  The level of MMP-9 and TIMP-1 in GCF may play an importance role in maintaining the health, the regular remodeling of the periodontium and the fast-moving of orthodontic tooth.
authors: Department of Stomatology in 184th Peole's Liberation Army Hospital, Yingtan 335000, China.
authors: Zhi-yu
authors: ZY
authors: Zhou
authors: Jiang-jun
authors: JJ
authors: Zhou
authors: Jiang-jun
authors: JJ
authors: Zhou
mesh_terms: D000293:Adolescent; D000328:Adult; D019245:Compressive Strength; D003799:Dental Stress Analysis; D005260:Female; D005883:Gingival Crevicular Fluid / Q000201:enzymology*; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis / Q000378:metabolism*; D009967:Orthodontic Appliances; D013314:Stress, Mechanical; D013718:Tensile Strength; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000096:biosynthesis / Q000378:metabolism*; D014087:Tooth Movement Techniques
chemical_list: D019715:Tissue Inhibitor of Metalloproteinase-1; D020780:Matrix Metalloproteinase 9