title: [Genome: does a paucity of initiation events lead to fragility?].
authors: Anne
authors: A
authors: Letessier
authors: Daniel
authors: D
authors: Birnbaum
authors: Michelle
authors: M
authors: Debatisse
authors: Max
authors: M
authors: Chaffanet
mesh_terms: D017766:Acid Anhydride Hydrolases / Q000235:genetics; D016590:Aphidicolin / Q000494:pharmacology; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D019457:Chromosome Breakage; D043283:Chromosome Fragile Sites / Q000187:drug effects / Q000235:genetics*; D004261:DNA Replication; D015894:Genome, Human; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism / Q000648:ultrastructure; D008938:Mitosis; D008957:Models, Genetic; D009363:Neoplasm Proteins / Q000235:genetics; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics; D009690:Nucleic Acid Conformation; D013314:Stress, Mechanical; D000099170:Bis(5'-adenosyl)triphosphatase
chemical_list: D017766:Acid Anhydride Hydrolases; D016590:Aphidicolin; D009363:Neoplasm Proteins; D000099170:Bis(5'-adenosyl)triphosphatase