title: Novel susceptibility locus at 22q11 for diabetic nephropathy in type 1 diabetes.
abstract: BACKGROUND
  Diabetic nephropathy (DN) affects about 30% of patients with type 1 diabetes (T1D) and contributes to serious morbidity and mortality. So far only the 3q21-q25 region has repeatedly been indicated as a susceptibility region for DN. The aim of this study was to search for new DN susceptibility loci in Finnish, Danish and French T1D families.
  
  
  RESULTS
  We performed a genome-wide linkage study using 384 microsatellite markers. A total of 175 T1D families were studied, of which 94 originated from Finland, 46 from Denmark and 35 from France. The whole sample set consisted of 556 individuals including 42 sib-pairs concordant and 84 sib-pairs discordant for DN. Two-point and multi-point non-parametric linkage analyses were performed using the Analyze package and the MERLIN software. A novel DN locus on 22q11 was identified in the joint analysis of the Finnish, Danish and French families by genome-wide multipoint non-parametric linkage analysis using the Kong and Cox linear model (NPL(pairs) LOD score 3.58). Nominal or suggestive evidence of linkage to this locus was also detected when the three populations were analyzed separately. Suggestive evidence of linkage was found to six additional loci in the Finnish and French sample sets.
  
  
  CONCLUSIONS
  This study identified a novel DN locus at chromosome 22q11 with significant evidence of linkage to DN. Our results suggest that this locus may be of importance in European populations. In addition, this study supports previously indicated DN loci on 3q21-q25 and 19q13.
authors: Folkhälsan Research Center, Folkhälsan Institute of Genetics, Biomedicum Helsinki, Helsinki, Finland. maija.wessman@helsinki.fi
authors: Maija
authors: M
authors: Wessman
authors: Carol
authors: C
authors: Forsblom
authors: Mari A
authors: MA
authors: Kaunisto
authors: Jenny
authors: J
authors: Söderlund
authors: Jorma
authors: J
authors: Ilonen
authors: Riitta
authors: R
authors: Sallinen
authors: Tero
authors: T
authors: Hiekkalinna
authors: Maija
authors: M
authors: Parkkonen
authors: Alexander P
authors: AP
authors: Maxwell
authors: Lise
authors: L
authors: Tarnow
authors: Hans-Henrik
authors: HH
authors: Parving
authors: Samy
authors: S
authors: Hadjadj
authors: Michel
authors: M
authors: Marre
authors: Leena
authors: L
authors: Peltonen
authors: Per-Henrik
authors: PH
authors: Groop
mesh_terms: D000328:Adult; D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D003718:Denmark; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology; D003928:Diabetic Nephropathies / Q000235:genetics* / Q000276:immunology; D005190:Family; D005260:Female; D005387:Finland; D005602:France; D008040:Genetic Linkage; D056426:Genetic Loci / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008297:Male; D035781:Siblings
chemical_list: D006680:HLA Antigens