title: [Brain tumor (germinoma) diagnosed after assessment for male late-onset hypogonadism syndrome: a case report].
abstract: A 44-year-old man suffered from sleep disturbance, headache, lack of energy and appetite loss. His local doctor recommended he consult our clinic for further examination of late-onset hypogonadism. His aging males' symptoms (AMS) and international index of erectile function (IIEF-5) scores were 62 and 1, respectively. His biochemistry revealed 0.29 mIU/ml luteinizing hormone (LH), 1.36 mIU/ml follicular stimulating hormone (FSH), 0.16 ng/ml total testosterone (TT) and＜0.6 pg/ml free testosterone (FT). Male hypogonadotropic hypogonadism was suspected from these results, He was then referred to a neurosurgeon for discrimination of intracranial disease where magnetic resonance imaging (MRI) revealed multiple intracranial tumors. An open brain biopsy was performed, and germinoma was diagnosed. After 4 courses of anti-cancer chemotherapy, complete remission was achieved. He was followed up endocrinologically by administration of testosterone injections along with other endocrinology replacement treatments. However, MRI 3 months later revealed tumor recurrence in the left lateral ventricle, and he has been receiving radiation therapy.
authors: The Department of Urology, Nagano Red Cross Hospital.
authors: Toshiyasu
authors: T
authors: Amano
authors: Masaya
authors: M
authors: Seki
authors: Tetsuya
authors: T
authors: Imao
authors: Katsuro
authors: K
authors: Takemae
authors: Akihiko
authors: A
authors: Kurashima
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis*; D018237:Germinoma / Q000175:diagnosis*; D006801:Humans; D007006:Hypogonadism / Q000150:complications*; D008297:Male; D013577:Syndrome