title: Solalyratins A and B, new anti-inflammatory metabolites from Solanum lyratum.
abstract: A new coumestan (solalyratin A, 1) and a novel cyclic eight-membered α,β-unsaturated ketone (solalyratin B, 3), together with three known compounds, puerariafuran (2), coumestrol (4) and 9-hydroxy-2',2'-dimethylpyrano[5',6':2,3]-coumestan (5), were isolated from the whole plant of Solanum lyratum. Their structures were elucidated on the basis of spectroscopic analyses. In vitro, compounds 1-5 showed anti-inflammatory activities, with IC(50) values in the range 6.3-9.1 μM.
authors: School of Pharmaceutical Science, Yantai University, 264005 Yantai, People's Republic of China.
authors: De-Wu
authors: DW
authors: Zhang
authors: Yan
authors: Y
authors: Yang
authors: Fang
authors: F
authors: Yao
authors: Qun-Ying
authors: QY
authors: Yu
authors: Sheng-Jun
authors: SJ
authors: Dai
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology*; D003374:Coumarins / Q000737:chemistry* / Q000494:pharmacology*; D007659:Ketones / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D032322:Solanum
chemical_list: D000893:Anti-Inflammatory Agents; D003374:Coumarins; D007659:Ketones; D010936:Plant Extracts; C505898:coumestan