title: Influence of viscous Rhodella grisea (Rhodophyceae) proteoglycan on chemically induced cough reflex.
abstract: An algal extracellular biopolymer (over 8.5 × 10(5)Da) composed of carbohydrates (52%) and protein (∼13%) has been isolated from a red alga Rhodella grisea growing in natural conditions by concentration of water medium, alcohol precipitation, dialysis and freeze-drying. This mucilagineous biopolymer contained xylose and its 3-O- and 4-O-methyl derivatives (∼63%), galactose (∼12%), glucuronic acid (11-12%), glucose (∼5%), rhamnose (∼4%), fucose (∼3-4%) and low content of others accompaning sugars. When tested on the citric acid-induced cough and reactivity of airways smooth muscle in vivo in the test system guinea pigs, this biopolymer assigned a significant cough suppressing effect. The reactivity of airways smooth muscle was not affected indicating that expectoration effect was not suppressed by biopolymer application, which is important from the pharmacological point of view.
authors: Department of Pharmacology, Jessenius faculty of Medicine, Comenius University, Sklabinská 26, SK-036 01 Martin, Slovakia.
authors: G
authors: G
authors: Nosáľová
authors: P
authors: P
authors: Capek
authors: D
authors: D
authors: Flešková
authors: L
authors: L
authors: Jureček
authors: F
authors: F
authors: Hindák
authors: J
authors: J
authors: Lukavský
authors: V
authors: V
authors: Cepák
authors: B
authors: B
authors: Ray
authors: E
authors: E
authors: Breierová
authors: J
authors: J
authors: Turjan
mesh_terms: D000280:Administration, Inhalation; D000284:Administration, Oral; D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D000996:Antitussive Agents; D001704:Biopolymers / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification; D016535:Bronchial Hyperreactivity / Q000517:prevention & control*; D019343:Citric Acid / Q000009:adverse effects; D003371:Cough / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D005612:Freeze Drying; D020723:Glucuronic Acid / Q000737:chemistry; D006168:Guinea Pigs; D008297:Male; D009005:Monosaccharides / Q000737:chemistry; D009130:Muscle, Smooth / Q000187:drug effects / Q000503:physiopathology; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification; D010991:Plethysmography; D011509:Proteoglycans / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification; D012018:Reflex / Q000187:drug effects / Q000502:physiology; D012137:Respiratory System / Q000187:drug effects* / Q000503:physiopathology; D000461:Rhodophyta / Q000737:chemistry*; D014783:Viscosity
chemical_list: D000996:Antitussive Agents; D001704:Biopolymers; D009005:Monosaccharides; D010936:Plant Extracts; D011509:Proteoglycans; D019343:Citric Acid; D020723:Glucuronic Acid