title: Association analysis of the adenosine A1 receptor gene polymorphisms in patients with methamphetamine dependence/psychosis.
abstract: Several lines of evidence suggest that the dopaminergic nervous system contributes to methamphetamine (METH) dependence, and there is increasing evidence of antagonistic interactions between dopamine and adenosine receptors in METH abusers. We therefore hypothesized that variations in the A1 adenosine receptor (ADORA1) gene modify genetic susceptibility to METH dependence/psychosis. In this study, we identified 7 single nucleotide polymorphisms (SNPs) in exons and exon-intron boundaries of the ADORA1 gene in a Japanese population. A total of 171 patients and 229 controls were used for an association analysis between these SNPs and METH dependence/psychosis. No significant differences were observed in either the genotypic or allelic frequencies between METH dependent/psychotic patients and controls. A global test of differentiation among samples based on haplotype frequencies showed no significant association. In the clinical feature analyses, no significant associations were observed among latency of psychosis, prognosis of psychosis, and spontaneous relapse. These results suggest that the ADORA1 gene variants may make little or no contribution to vulnerability to METH dependence/psychosis.
authors: Department of Biological Psychiatry, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.
authors: Hideaki
authors: H
authors: Kobayashi
authors: Hiroshi
authors: H
authors: Ujike
authors: Nakao
authors: N
authors: Iwata
authors: Toshiya
authors: T
authors: Inada
authors: Mitsuhiko
authors: M
authors: Yamada
authors: Yoshimoto
authors: Y
authors: Sekine
authors: Naohisa
authors: N
authors: Uchimura
authors: Masaomi
authors: M
authors: Iyo
authors: Norio
authors: N
authors: Ozaki
authors: Masanari
authors: M
authors: Itokawa
authors: Ichiro
authors: I
authors: Sora