title: Genetic Association Analysis of NOS3 and Methamphetamine-Induced Psychosis Among Japanese.
abstract: Endothelial nitric oxide synthase (NOS3) is one of the enzymes influencing nitric oxide (NO) function in the human brain. NO is a gaseous neurotransmitter that is involved in a variety of mechanisms in the central nervous system, such as N-methyl-D-aspartate receptor activation and oxidative stress. The evidence from animal pharmacological studies and postmortem studies supports an association between NO and psychotic disorders. Methamphetamine (METH) use disorder is a known psychotic disorder, and we therefore conducted a gene-based case-control study between tagging single nucleotide polymorphisms (SNPs) (rs2070744, rs1799983) in NOS3 and METH-induced psychosis in Japanese subjects (183 with METH-induced psychosis and 267 controls). Written informed consent was obtained from each subject. No significant association was found between any tagging SNP in NOS3 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, we suggest that NOS3 might not contribute to the risk of METH-induced psychosis in the Japanese population.
authors: Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan.
authors: T
authors: T
authors: Okochi
authors: T
authors: T
authors: Kishi
authors: M
authors: M
authors: Ikeda
authors: T
authors: T
authors: Kitajima
authors: Y
authors: Y
authors: Kinoshita
authors: K
authors: K
authors: Kawashima
authors: T
authors: T
authors: Okumura
authors: T
authors: T
authors: Tsunoka
authors: Y
authors: Y
authors: Fukuo
authors: T
authors: T
authors: Inada
authors: M
authors: M
authors: Yamada
authors: N
authors: N
authors: Uchimura
authors: M
authors: M
authors: Iyo
authors: I
authors: I
authors: Sora
authors: N
authors: N
authors: Ozaki
authors: H
authors: H
authors: Ujike
authors: N
authors: N
authors: Iwata