title: Antigenotoxic and antioxidant activities of palmarosa and citronella essential oils.
abstract: BACKGROUND
  Essential oils of palmarosa and citronella have been extensively used in ancient Indian and South-east Asian traditional medicines.
  
  
  OBJECTIVE
  These essential oils have been reported to exhibit antimicrobial, anti parasitic effects against bacteria, yeasts, filamentous fungi, and viruses. In the present study the oils were tested for their potential antigenotoxic and antioxidant properties in human lymphocyte cells.
  
  
  METHODS
  The antigenotoxic effect on human lymphocyte cells (measurement of cell viability, DNA damage) was studied using trypan blue dye exclusion test, plasmid pBR322 DNA strand scission, and comet assay. Anti-oxidant activity was evaluated by DPPH(+) free radical scavenging and lipid peroxidation assay.
  
  
  RESULTS
  The essential oils showed a good antigenotoxic activity against methyl methanesulphonate (MMS) and hydrogen peroxide. In addition, a significant dose dependent antioxidant activity was observed.
  
  
  CONCLUSIONS
  Our data provide evidence that support the usage of palmarosa and citronella essential oils in traditional herbal preparations. They can constitute a natural source of a new and safe antioxidant.
authors: Cell Biology and Genetic Toxicology Unit, Department of Botany, University of Calcutta, 35 Ballygunge Circular Road, Kolkata 700019, India. sonali.csir@gmail.com
authors: Sonali
authors: S
authors: Sinha
authors: Dhrubojyoti
authors: D
authors: Biswas
authors: Anita
authors: A
authors: Mukherjee
mesh_terms: D016587:Antimutagenic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D020552:Comet Assay; D031743:Cymbopogon / Q000737:chemistry; D004249:DNA Damage / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D008297:Male; D009153:Mutagens / Q000633:toxicity; D009822:Oils, Volatile / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D016877:Oxidants / Q000633:toxicity; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010938:Plant Oils / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D014466:Ultraviolet Rays; D055815:Young Adult
chemical_list: D016587:Antimutagenic Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D009153:Mutagens; D009822:Oils, Volatile; D016877:Oxidants; D010851:Picrates; D010936:Plant Extracts; D010938:Plant Oils; C004931:1,1-diphenyl-2-picrylhydrazyl; C076730:citronella oil