title: Safety and efficacy of exercise training in patients with an idiopathic inflammatory myopathy--a systematic review.
abstract: OBJECTIVE
  Idiopathic inflammatory myopathies (IIMs) are a group of rare heterogeneous autoimmune skeletal muscle disorders characterized by muscle weakness, excessive muscle fatigue and diminished aerobic fitness. Exercise training could be one way to prevent or delay the negative effects of the disease and the impairments seen in patients with an IIM. The objective was to examine whether exercise training is safe and effective in patients with an IIM.
  
  
  METHODS
  All experimental studies that assessed the safety and/or efficacy of an exercise training programme in patients with an IIM except for case studies were reviewed. Pre-MEDLINE, MEDLINE and EMBASE database searching was done up to November 2010. Information was extracted on the number of participants, characteristics of participants, type of intervention, type of outcome measure, type of study design, report characteristics, geographical origin and risk of bias within studies. The change (percentage and significance) in group mean or median for each outcome measure in each study was determined as well.
  
  
  RESULTS
  Two randomized controlled trials, one non-randomized controlled trial and nine uncontrolled trials were included. No studies in children were found. Safety measures did not worsen and efficacy measures improved or did not change. Most of the included studies had a high selection and/or allocation bias.
  
  
  CONCLUSIONS
  In conclusion, it appears that exercise training is safe and effective in adult patients with active as well as inactive stable IIMs. However, more studies with a well-controlled design are needed. In addition, studies in children with an IIM are indicated.
authors: Child Development and Exercise Center, Wilhelmina Children's Hospital, University Medical Center Utrecht, Room KB2.056.0, PO Box 85090, 3508 AB Utrecht, The Netherlands.
authors: Gerarda E A
authors: GE
authors: Habers
authors: Tim
authors: T
authors: Takken
mesh_terms: D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy / Q000009:adverse effects* / Q000379:methods* / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008297:Male; D009220:Myositis / Q000503:physiopathology / Q000534:rehabilitation / Q000628:therapy*; D010809:Physical Fitness; D016032:Randomized Controlled Trials as Topic; D012107:Research Design; D015983:Selection Bias; D016896:Treatment Outcome