title: Engineering of microorganisms for the production of biofuels and perspectives based on systems metabolic engineering approaches.
abstract: The increasing oil price and environmental concerns caused by the use of fossil fuel have renewed our interest in utilizing biomass as a sustainable resource for the production of biofuel. It is however essential to develop high performance microbes that are capable of producing biofuels with very high efficiency in order to compete with the fossil fuel. Recently, the strategies for developing microbial strains by systems metabolic engineering, which can be considered as metabolic engineering integrated with systems biology and synthetic biology, have been developed. Systems metabolic engineering allows successful development of microbes that are capable of producing several different biofuels including bioethanol, biobutanol, alkane, and biodiesel, and even hydrogen. In this review, the approaches employed to develop efficient biofuel producers by metabolic engineering and systems metabolic engineering approaches are reviewed with relevant example cases. It is expected that systems metabolic engineering will be employed as an essential strategy for the development of microbial strains for industrial applications.
authors: Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 Program), BioProcess Engineering Research Center, Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, KAIST, Daejeon, Republic of Korea.
authors: Yu-Sin
authors: YS
authors: Jang
authors: Jong Myoung
authors: JM
authors: Park
authors: Sol
authors: S
authors: Choi
authors: Yong Jun
authors: YJ
authors: Choi
authors: Do Young
authors: do Y
authors: Seung
authors: Jung Hee
authors: JH
authors: Cho
authors: Sang Yup
authors: SY
authors: Lee
mesh_terms: D001419:Bacteria / Q000378:metabolism*; D056804:Biofuels / Q000382:microbiology*; D060847:Metabolic Engineering / Q000379:methods*; D049490:Systems Biology / Q000379:methods*
chemical_list: D056804:Biofuels