title: Chemerin levels are positively correlated with abdominal visceral fat accumulation.
abstract: OBJECTIVE
  Chemerin, a recently discovered adipocytokine, may be linked to obesity and obesity-associated metabolic complications. However, the relationship between visceral fat accumulation and chemerin is still unknown. Therefore, we investigated the relationship between serum chemerin levels and body composition as measured by computed tomography (CT).
  
  
  METHODS
  We recruited 173 men and women without histories of diabetes or cardiovascular disease.
  
  
  METHODS
  Biomarkers of metabolic risk factors and body composition by computed tomography were assessed. Serum chemerin levels were measured by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Chemerin levels correlated with body mass index (BMI), waist circumference, abdominal visceral fat area, blood pressure, fasting insulin, homoeostasis model of assessment-insulin resistance, total cholesterol, triglyceride, creatinine, aspartate aminotransferase and alanine aminotransferase. By stepwise multiple regression analysis, abdominal visceral fat area, blood pressure and total cholesterol levels independently affected chemerin levels.
  
  
  CONCLUSIONS
  Abdominal visceral fat accumulation, blood pressure and lipid profile were significantly associated with serum chemerin levels. Our findings suggest that chemerin may be a mediator that links visceral obesity to cardiovascular risk factors.
authors: Department of Family Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors: Hyun-Young
authors: HY
authors: Shin
authors: Duk C
authors: DC
authors: Lee
authors: Sang H
authors: SH
authors: Chu
authors: Justin Y
authors: JY
authors: Jeon
authors: Mi K
authors: MK
authors: Lee
authors: Jee A
authors: JA
authors: Im
authors: Ji W
authors: JW
authors: Lee
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D001823:Body Composition / Q000502:physiology; D002318:Cardiovascular Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology; D018925:Chemokines / Q000032:analysis / Q000097:blood*; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging; D011859:Radiography; D012307:Risk Factors; D015898:Tomography Scanners, X-Ray Computed; D055815:Young Adult
chemical_list: D015415:Biomarkers; D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human