title: Increased microglial activation in the rat brain following neonatal exposure to a bacterial mimetic.
abstract: Neonatal lipopolysaccharide (LPS) exposure increases anxiety-like behaviour in adulthood. Our current aim was to examine whether neonatal LPS exposure is associated with changes in microglial activation, and whether these alterations correspond with alterations in behaviour. In adulthood, LPS-treated animals exhibited significantly increased anxiety-like behaviour and hippocampal microglial activation. The efficacy of the LPS challenge was confirmed by increased neonatal plasma corticosterone and tyrosine hydroxylase (TH) phosphorylation in the adrenal medulla. These findings suggest a neuroimmune pathway which may underpin the long-term behavioural and neuroendocrine changes following neonatal infection.
authors: Laboratory of Neuroimmunology, School of Psychology, The University of Newcastle, Australia. luba.sominsky@newcastle.edu.au
authors: L
authors: L
authors: Sominsky
authors: A K
authors: AK
authors: Walker
authors: L K
authors: LK
authors: Ong
authors: R J
authors: RJ
authors: Tynan
authors: F R
authors: FR
authors: Walker
authors: D M
authors: DM
authors: Hodgson
mesh_terms: D000313:Adrenal Medulla / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D001007:Anxiety / Q000139:chemically induced* / Q000276:immunology; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D003345:Corticosterone / Q000097:blood; D006624:Hippocampus / Q000187:drug effects* / Q000276:immunology; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D008070:Lipopolysaccharides / Q000494:pharmacology*; D017628:Microglia / Q000187:drug effects* / Q000276:immunology; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D051381:Rats; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D008070:Lipopolysaccharides; D014446:Tyrosine 3-Monooxygenase; D003345:Corticosterone