title: [Differentially expressed genes in asthenospermia: a bioinformatics-based study].
abstract: OBJECTIVE
  To study the differentially expressed genes in asthenospermia to gain a deeper insight into the molecular mechanisms of the disease.
  
  
  METHODS
  We analyzed the differentially expressed genes in asthenospermia using GATHER, PANTHER and ToppGene online bioinformatics tools.
  
  
  RESULTS
  Our bioinformatics mining and analyses revealed that the differentially expressed genes in asthenospermia played important roles in the cellular protein and macromolecular metabolism, protein modification, cell death, cell apoptosis and apoptosis induction.
  
  
  CONCLUSIONS
  Asthenospermia patients experience a decline in sperm activity and the basic life activities of sperm simultaneously, and are also prone to cell apoptosis or death. Such differentially expressed genes as KIF3B, MYO15A, KIF6, KIF26B, KIF3A, DNHD2, DMN, DYNC2H1, STARD9, MYOHD1, and TPM1, which are involved in cytoskeletal structure, microtubule movement and cell movement, may be associated with asthenospermia, and therefore deserve further studies.
authors: Department of Urology, Nanfang Hospital, Guangdong 510515, China. mxm@fimmu.com
authors: Xiang-Ming
authors: XM
authors: Mao
authors: Rong-Wei
authors: RW
authors: Xing
authors: Xiao-Wei
authors: XW
authors: Jing
authors: Qi-Zhao
authors: QZ
authors: Zhou
authors: Qing-Feng
authors: QF
authors: Yu
authors: Wen-Bin
authors: WB
authors: Guo
authors: Xiao-Qiang
authors: XQ
authors: Wu
authors: Qing-Jun
authors: QJ
authors: Chu
authors: Chun-Qiong
authors: CQ
authors: Feng
mesh_terms: D053627:Asthenozoospermia / Q000235:genetics* / Q000378:metabolism; D019295:Computational Biology; D030541:Databases, Genetic; D020869:Gene Expression Profiling; D006801:Humans; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D013094:Spermatozoa / Q000378:metabolism