title: [Synthesis and antiviral activities of geldanamycin analog TC-GM in vitro].
abstract: In order to find antiviral compounds with novel structures, geldanamycin and lamivudine with different antiviral mechanisms were conjunctively synthesized to acquire a new compound TC-GM, and the antiviral activity of TC-GM was measured. The antiviral activity against HIV-1 was examined by p24 antigen ELISA kit. The activity against HBV was examined by dotblot. The activity against HSV and CoxB virus was examined by CPE. TC-GM exhibited broad-spectrum antiviral activities similarly like geldanamycin. TC-GM inhibited the replication of different viruses, including HIV-1, HBV, HSV 1 and 2, CoxB6. TC-GM showed more potent inhibitory activity against HIV-1 and HBV than other detected virus.
authors: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
authors: Chun-Xin
authors: CX
authors: Li
authors: Guang-Zhi
authors: GZ
authors: Shan
authors: Bo
authors: B
authors: Fan
authors: Pei-Zhen
authors: PZ
authors: Tao
authors: Li-Xun
authors: LX
authors: Zhao
authors: Jian-Dong
authors: JD
authors: Jiang
authors: Yu-Huan
authors: YH
authors: Li
authors: Zhuo-Rong
authors: ZR
authors: Li
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D016227:Benzoquinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002522:Chlorocebus aethiops; D029822:Enterovirus B, Human / Q000187:drug effects / Q000502:physiology; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology; D056945:Hep G2 Cells; D006515:Hepatitis B virus / Q000187:drug effects / Q000502:physiology; D018259:Herpesvirus 1, Human / Q000187:drug effects / Q000502:physiology; D018258:Herpesvirus 2, Human / Q000187:drug effects / Q000502:physiology; D006801:Humans; D047029:Lactams, Macrocyclic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D019259:Lamivudine / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D061985:Madin Darby Canine Kidney Cells; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology / Q000821:virology; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D019380:Anti-HIV Agents; D000998:Antiviral Agents; D016227:Benzoquinones; D047029:Lactams, Macrocyclic; D019259:Lamivudine; C001277:geldanamycin