title: Body iron stores as predictors of insulin resistance in apparently healthy urban Colombian men.
abstract: The aim of this study was to evaluate body iron stores as predictors of insulin resistance. We developed a cross-sectional study among 123 men, 25-64 years of age and determined fasting plasma glucose, insulin, serum ferritin, and C-reactive protein levels. A survey was performed to record personal antecedents and family history of non-transmissible chronic diseases. Log-transformed ferritin levels was an independent predictor for log-transformed insulin resistance index assessed by homeostatic model assessment when body mass index or waist circumference were not included in multiple linear regression models. Sedentarism, heart attack family history, and log-C reactive protein levels were also significant predictors for insulin resistance. In conclusion, documented anthropometric predictors affect the significance of ferritin as a potential prediction variable for insulin resistance. Mechanisms of how body fat could influence ferritin levels should be evaluated. To our knowledge, this is the first evaluation of the relationship between body iron stores and insulin resistance in a Latin American population.
authors: Department of Physiological Sciences, Universidad del Valle, Cali, Colombia. fabian.suarezuv@gmail.com
authors: Milton Fabian
authors: MF
authors: Suárez-Ortegón
authors: Alejandra
authors: A
authors: Arbeláez
authors: Mildrey
authors: M
authors: Mosquera
authors: Fabián
authors: F
authors: Méndez
authors: Cecilia
authors: C
authors: Aguilar-de Plata
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001822:Body Burden; D002097:C-Reactive Protein / Q000378:metabolism; D003105:Colombia; D005293:Ferritins / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D007501:Iron / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D014505:Urban Population
chemical_list: D001786:Blood Glucose; D007328:Insulin; D002097:C-Reactive Protein; D005293:Ferritins; D007501:Iron