title: Adiponectin is Associated with Impaired Fasting Glucose in the Non-Diabetic Population.
abstract: OBJECTIVE
  Adiponectin is strongly associated with diabetes in the Western population. However, whether adiponectin is independently associated with impaired fasting glucose (IFG) in the non-obese population is unknown.
  
  
  METHODS
  The serum adiponectin, insulin resistance (IR), and waist circumference (WC) of 27,549 healthy Koreans were measured. Individuals were then classified into tertile groups by gender. IFG was defined as a fasting serum glucose of 100-125 mg/dL without diabetes. IR was calculated using the homeostasis model assessment of insulin resistance (HOMA-IR). The association of adiponectin and IFG was determined using logistic regression analysis.
  
  
  RESULTS
  WC and adiponectin were associated with IFG in both men and women. However, the association of WC with IFG was attenuated in both men and women after adjustment for the HOMA-IR. Adiponectin was still associated with IFG after adjustment for and stratification by HOMA-IR in men and women. Strong combined associations of IR and adiponectin with IFG were observed in men and women. Multivariate adjusted odds ratios (ORs) (95% confidence interval [CI]) among those in the highest tertile of IR and the lowest tertile of adiponectin were 9.8 (7.96 to 12.07) for men and 24.1 (13.86 to 41.94) for women.
  
  
  CONCLUSIONS
  These results suggest that adiponectin is strongly associated with IFG, and point to adiponectin as an additional diagnostic biomarker of IFG in the non-diabetic population.
authors: Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea.
authors: Sang Yeun
authors: SY
authors: Kim
authors: Sun Ju
authors: SJ
authors: Lee
authors: Hyoun Kyoung
authors: HK
authors: Park
authors: Ji Eun
authors: JE
authors: Yun
authors: Myoungsook
authors: M
authors: Lee
authors: Jidong
authors: J
authors: Sung
authors: Sun Ha
authors: SH
authors: Jee