title: [Antileukemic activity and development of resistance to cisplatin (CPT) and platinum (IV)-nitroxyl complex VS118].
abstract: Treatment with low doses (1/10 of LD50) of cisplatin and platinum (IV)-nitroxyl complex VS118 [e-ammin-d-(4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl)-a,f-bi s(acetate)-b,c-dichlorplatinum (IV)] was followed by a synergistic therapeutic effect (a 100% cure of animals) as compared with monotherapy with either drug. There was no synergistic increase in toxicity. The rates of resistance development decreased in the following order: P388/cPt+VS118, P388/cPt, P388/VS118. Resistant strains P388/cPt+VS18 and P388/VS118 were highly sensitive to doxorubicin, etoposide and cyclophoshamide. Further research in cPt+VS 118 combinations should be continued.
authors: S A
authors: SA
authors: Goncharova
authors: T A
authors: TA
authors: Raevskaia
authors: T N
authors: TN
authors: Iakushchenko
authors: S V
authors: SV
authors: Blokhina
authors: N P
authors: NP
authors: Konovalova
authors: V D
authors: VD
authors: Sen'
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm; D004357:Drug Synergism; D005047:Etoposide / Q000494:pharmacology; D007941:Leukemia P388 / Q000188:drug therapy*; D051379:Mice; D009589:Nitrogen Oxides / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D017671:Platinum Compounds / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D009589:Nitrogen Oxides; D009944:Organoplatinum Compounds; D017671:Platinum Compounds; C561326:VS118; D005047:Etoposide; D004317:Doxorubicin; D003520:Cyclophosphamide; C039900:nitroxyl; D002945:Cisplatin