title: [Evaluation of antifungal effects of a traditional medicine containing 17 components on Trichophyton verrucosum and Malassezia pachydermatis by microdilution].
abstract: The minimum inhibitory concentration(MIC)of a traditional medicine containing 17 components against 9 strains of Trichophyton verrucosum and 13 strains of Malassezia pachydermatis was determined using a method recommended by the Clinical and Laboratory Standards Institute(CLSI). We also measured the MIC of each of the 17 components using the same method, and identified the main antifungal components.In order to evaluate MIC as a parameter of the antifungal effects using the microdilution method, we prepared 10% working solutions from 10% (w/v)medicines. The geometric mean MIC of the medicinal extract against T. verrucosum was 2.51%, and that against M. pachydermatis was 2.25%. The components that exhibited antifungal effects were Rheum palmatum, Glycyrrhiza uralensis, Magnolia obovata, Phellodendron amurense, and Geranium thunbergii.
authors: Miyazaki Prefectural Industrial Support Foundation.
authors: Naoko
authors: N
authors: Nishikata
authors: Kentaro
authors: K
authors: Nakamori
authors: Masuo
authors: M
authors: Sueyoshi
authors: Hideo
authors: H
authors: Takahashi
authors: Hiroyuki
authors: H
authors: Yuji
authors: Ayako
authors: A
authors: Sano
mesh_terms: D000818:Animals; D025141:Drug Resistance, Fungal; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology*; D008290:Malassezia / Q000187:drug effects*; D008826:Microbial Sensitivity Tests / Q000379:methods*; D014249:Trichophyton / Q000187:drug effects*
chemical_list: D004365:Drugs, Chinese Herbal