title: Methyltransferase activity of an iridium center with methylpyridinium as methylene source.
abstract: Hop on, hop off: an iridium center transfers a methyl group from pyridinium to an aryl unit, using exclusively the pyridine-bound methyl group as a mild methylene source. The reaction also involves cleavage of an unactivated C(aryl)-H bond and nitrile solvent activation. The process is reminiscent of DNA methylation and entails the formation of two new C(sp(2))-C(sp(3)) bonds within the metal coordination sphere.
authors: School of Chemistry & Chemical Biology, University College Dublin, Belfield, Ireland.
authors: Ralte
authors: R
authors: Lalrempuia
authors: Helge
authors: H
authors: Müller-Bunz
authors: Martin
authors: M
authors: Albrecht
mesh_terms: D007495:Iridium / Q000737:chemistry / Q000378:metabolism*; D008780:Methyltransferases / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D011726:Pyridinium Compounds / Q000737:chemistry / Q000378:metabolism*
chemical_list: D009942:Organometallic Compounds; D011726:Pyridinium Compounds; D007495:Iridium; D008780:Methyltransferases