title: Toxicology and risk assessment of acrolein in food.
abstract: Acrolein is an α,β-unsaturated aldehyde formed by thermal treatment of animal and vegetable fats, carbohydrates and amino acids. In addition it is generated endogenously. As an electrophile, acrolein forms adducts with gluthathione and other cellular components and is therefore cytotoxic. Mutagenicity was shown in some in vitro tests. Acrolein forms different DNA adducts in vivo, but mutagenic and cancerogenous effects have not been demonstrated for oral exposure. In subchronic oral studies, local lesions were detected in the stomach of rats. Systemic effects have not been reported from basic studies. A WHO working group established a tolerable oral acrolein intake of 7.5 μg/kg body weight/day. Acrolein exposure via food cannot be assessed due to analytical difficulties and the lack of reliable content measurements. Human biomonitoring of an acrolein urinary metabolite allows rough estimates of acrolein exposure in the range of a few μg/kg body weight/day. High exposure could be ten times higher after the consumption of certain foods. Although the estimation of the dietary acrolein exposure is associated with uncertainties, it is concluded that a health risk seems to be unlikely.
authors: Federal Institute for Risk Assessment (BfR), Berlin, Germany.
authors: Klaus
authors: K
authors: Abraham
authors: Susanne
authors: S
authors: Andres
authors: Richard
authors: R
authors: Palavinskas
authors: Katharina
authors: K
authors: Berg
authors: Klaus E
authors: KE
authors: Appel
authors: Alfonso
authors: A
authors: Lampen
mesh_terms: D000171:Acrolein / Q000493:pharmacokinetics* / Q000633:toxicity* / Q000652:urine; D000284:Administration, Oral; D000818:Animals; D015197:Carcinogenicity Tests; D018736:DNA Adducts; D004285:Dogs; D005502:Food / Q000633:toxicity*; D005504:Food Analysis / Q000379:methods; D005858:Germany; D006801:Humans; D009152:Mutagenicity Tests; D051381:Rats; D018570:Risk Assessment; D011198:Solanum tuberosum / Q000737:chemistry; D018675:Toxicity Tests; D023382:Toxicity Tests, Acute; D036401:Toxicity Tests, Chronic; D059550:Toxicity Tests, Subchronic
chemical_list: D018736:DNA Adducts; D000171:Acrolein