title: Capsiate, a non-pungent capsaicin analog, reduces body fat without weight rebound like swimming exercise in mice.
abstract: Enhancement of energy expenditure and reducing energy intake are crucial for weight control. Capsiate, a non-pungent capsaicin analog, is known to suppress body fat accumulation and reduce body weight by enhancing of energy expenditure in both mice and humans. However, it is poorly understood whether suppressing body fat accumulation by capsiate administration is equal to exercise or not. The aim of this study is to compare the effects of repeated administration of capsiate and exercise and to investigate the weight rebound after repeated capsiate administration and/or exercise. In the present study, we report that 2 weeks treatment of capsiate and exercise increased energy metabolism and suppressed body fat accumulation during 4 more weeks of ad libitum feeding. The body weight in capsiate and exercise groups was significantly lower than that of control group. The oxygen consumption was significanlty increased in capsiate and exercise groups than in the vehicle administered mice. In addition, the abdominal adipose tissue weight in capsiate and exercise groups was significantly lower than that of control group. These results indicate that suppressing body fat accumulation by capsiate intake is beneficial for maintaining an ideal body weight as exercise.
authors: Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan.
authors: Satoshi
authors: S
authors: Haramizu
authors: Fuminori
authors: F
authors: Kawabata
authors: Koichiro
authors: K
authors: Ohnuki
authors: Naohiko
authors: N
authors: Inoue
authors: Tatsuo
authors: T
authors: Watanabe
authors: Susumu
authors: S
authors: Yazawa
authors: Tohru
authors: T
authors: Fushiki
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology / Q000187:drug effects*; D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D002211:Capsaicin / Q000031:analogs & derivatives* / Q000494:pharmacology; D002149:Energy Intake; D004734:Energy Metabolism / Q000187:drug effects*; D006801:Humans; D008297:Male; D051379:Mice; D009929:Organ Size; D010101:Oxygen Consumption / Q000187:drug effects; D013550:Swimming
chemical_list: C470213:capsiate; D002211:Capsaicin