title: CD4 T cell dependent tumor immunity stimulated by dendritic cell based vaccine.
abstract: CD8 CTLs have been accountable for the major effector cells responsible for the rejection of tumor cells. And CD40 signaling and IL-12 have been shown to be the essential pathways involved in the activation process. Immunizing mice with dendritic cells transduced with an adenovirus expressing the human melanoma antigen gp 100, an immunization strategy of xenoimmunization, stimulated potent tumor protection dependent on effective CD4 T cells in the absence of CD8 T cells. Further studies revealed that neither CD40 signaling nor IL-12 was indispensable for the activation of dendritic and CD4 T cells in this model. Stimulation of effective antitumor immunity targeting the self-antigen did not elicit autoimmunity. The implications of this study were discussed.
authors: Department of Medical Oncology, Cancer Hospital of Fudan University, Shanghai, China. wozhangsheng@hotmail.com
authors: Sheng
authors: S
authors: Zhang
authors: Wenfeng
authors: W
authors: Li
authors: Zuguang
authors: Z
authors: Xia
authors: Yixiang
authors: Y
authors: Mao
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D019013:CD40 Antigens / Q000276:immunology; D019496:Cancer Vaccines / Q000235:genetics / Q000276:immunology* / Q000627:therapeutic use; D003713:Dendritic Cells / Q000276:immunology* / Q000637:transplantation; D018664:Interleukin-12 / Q000276:immunology; D008213:Lymphocyte Activation; D008546:Melanoma, Experimental / Q000276:immunology / Q000517:prevention & control*; D051379:Mice; D008810:Mice, Inbred C57BL; D023041:Xenograft Model Antitumor Assays; D058951:gp100 Melanoma Antigen / Q000235:genetics / Q000276:immunology*
chemical_list: D019013:CD40 Antigens; D019496:Cancer Vaccines; D058951:gp100 Melanoma Antigen; D018664:Interleukin-12