title: Acellular dermal matrix in breast reconstruction in the setting of radiotherapy.
abstract: Acellular dermal matrices (ADM) are becoming an integral component of immediate implant-based breast reconstruction, providing inferolateral coverage and support of the implant. Currently, five ADM products are available on the market for this purpose. Although their application has resulted in improved aesthetic results with low complication rates, the clinical performance of ADM when radiotherapy is a component of breast cancer treatment has yet to be defined. In this article, we present a thorough review of the current literature on the performance of ADM in the setting of radiotherapy from both animal and human studies, including our own experience with two proprietary ADM products. The other three products have little literature documenting their application for this type of reconstruction, and further studies specifically evaluating the performance of all ADM formulations in the setting of radiotherapy are still needed.
authors: Division of Plastic Surgery, Department of Surgery, Hofstra University School of Medicine, in partnership with North Shore-LIJ Health System, Hempstead, New York, USA. risraeli@bodyplasticsurgery.com
authors: Ron
authors: R
authors: Israeli
authors: Randall S
authors: RS
authors: Feingold
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use; D019928:Breast Implantation / Q000379:methods*; D018427:Breast Implants; D001943:Breast Neoplasms / Q000532:radiotherapy / Q000601:surgery*; D003094:Collagen / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D016462:Mammaplasty / Q000379:methods; D018714:Radiotherapy, Adjuvant / Q000379:methods
chemical_list: C440568:Alloderm; D001672:Biocompatible Materials; C568444:strattice; D003094:Collagen