title: Disruption of xCT inhibits cell growth via the ROS/autophagy pathway in hepatocellular carcinoma.
abstract: xCT, the functional subunit of the system x(c)(-) which plays an important role in maintaining intracellular glutathione (GSH) levels, is expressed in various malignant tumors. Here, we demonstrated that xCT expression is often elevated in HCC and is associated with poor prognosis in HCC patients; moreover, disruption of xCT suppressed HCC cell growth both in vitro and in vivo. xCT dysfunction has also been shown to increase intracellular reactive oxygen species (ROS) levels, thus in turn led to autophagic cell death of HCC cells. Taken together, these findings suggest that xCT may be a promising therapeutic target for human HCC.
authors: Shanghai Medical College, Fudan University, Shanghai 200032, China. guoweijie1986@hotmail.com
authors: Weijie
authors: W
authors: Guo
authors: Yingjun
authors: Y
authors: Zhao
authors: Zhenfeng
authors: Z
authors: Zhang
authors: Ning
authors: N
authors: Tan
authors: Fangyu
authors: F
authors: Zhao
authors: Chao
authors: C
authors: Ge
authors: Linhui
authors: L
authors: Liang
authors: Deshui
authors: D
authors: Jia
authors: Taoyang
authors: T
authors: Chen
authors: Ming
authors: M
authors: Yao
authors: Jinjun
authors: J
authors: Li
authors: Xianghuo
authors: X
authors: He
mesh_terms: D027182:Amino Acid Transport System y+ / Q000037:antagonists & inhibitors* / Q000096:biosynthesis* / Q000172:deficiency / Q000235:genetics; D000818:Animals; D001343:Autophagy / Q000502:physiology*; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D048708:Cell Growth Processes / Q000502:physiology; D045744:Cell Line, Tumor; D005260:Female; D055785:Gene Knockdown Techniques; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012460:Sulfasalazine / Q000494:pharmacology; D014162:Transfection; D023041:Xenograft Model Antitumor Assays
chemical_list: D027182:Amino Acid Transport System y+; D012333:RNA, Messenger; D017382:Reactive Oxygen Species; C118895:SLC7A11 protein, human; D012460:Sulfasalazine; D005978:Glutathione