title: [Research progress of new antibacterial drugs that target bacterial quorum sensing systems].
abstract: In recent years, antibiotic resistance of bacteria has become a global health crisis. Especially, the new class of "superbug" was found in South Asia, which is resistant to almost known antibiotics and causes worldwide alarm. Through the underlying mechanisms of bacterial pathogenecity, the expression of many pathogen virulence factors is regulated by the process of quorum sensing. Screening efficient quorum sensing inhibitors is an especially compelling approach to the future treatment of bacterial infections and antibiotic resistance. This article focuses on bacterial quorum sensing system, quorum sensing screening model for in vitro and evaluation of animal models in vivo, recent research of quorum sensing inhibitors and so on.
authors: Key Laboratory of Marine Drugs, Ministry of Education, College of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
authors: Shou-Liang
authors: SL
authors: Yin
authors: Ya-Jing
authors: YJ
authors: Chang
authors: Su-Ping
authors: SP
authors: Deng
authors: Qing-Chi
authors: QC
authors: Wang
authors: Wen-Gong
authors: WG
authors: Yu
authors: Qian-Hong
authors: QH
authors: Gong
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy; D004195:Disease Models, Animal; D024881:Drug Resistance, Bacterial; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D006801:Humans; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000472:pathogenicity / Q000502:physiology*; D053038:Quorum Sensing / Q000187:drug effects* / Q000502:physiology; D014774:Virulence / Q000187:drug effects; D037521:Virulence Factors / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D004365:Drugs, Chinese Herbal; D037521:Virulence Factors