title: Neutrophilic dermatosis revisited: an initial presentation of lupus?
abstract: BACKGROUND
  We report 7 patients with a distinct and unusual eruption consisting of a neutrophilic dermatosis in conjunction with lupus erythematosus (LE). The significance of these findings and their relevance to LE are discussed.
  
  
  OBJECTIVE
  We aimed to evaluate the significance of eruptive neutrophilic dermatosis in conjunction with LE.
  
  
  METHODS
  Seven original cases were collected during 10 years at a tertiary referral center, and were reviewed by a single board-certified dermatopathologist. All patient demographics were tabulated and analyzed. Eleven articles reporting 15 similar cases were obtained from a literature review.
  
  
  RESULTS
  Of a total of 7 adult patients, 14% (1 of 7) had a history of LE, whereas 86% (6 of 7) exhibited synchronous initial presentation of neutrophilic dermatosis with LE. Of note, 100% (7 of 7) of the patients exhibited cutaneous lesions on sun-exposed sites.
  
  
  CONCLUSIONS
  Only 7 of 400,000 cases showed this phenomenon, giving rise to the idea this may be just by chance.
  
  
  CONCLUSIONS
  Our data and literature review suggest the existence of a neutrophilic dermatosis distinct from conventional Sweet syndrome that may herald conventional signs and symptoms or represent an initial presentation of cutaneous LE. This neutrophilic dermatosis may share a similar pathogenic mechanism related to ultraviolet exposure.
authors: Department of Pathology and Laboratory Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA.
authors: Peter
authors: P
authors: Pavlidakey
authors: Omie
authors: O
authors: Mills
authors: Sean
authors: S
authors: Bradley
authors: Joseph
authors: J
authors: Casey
authors: Michael B
authors: MB
authors: Morgan
mesh_terms: D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008178:Lupus Erythematosus, Cutaneous / Q000175:diagnosis / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000473:pathology*; D012867:Skin / Q000473:pathology*; D016463:Sweet Syndrome / Q000175:diagnosis* / Q000473:pathology