title: Sequence variants in the bovine nucleophosmin 1 gene, their linkage and their associations with body weight in native cattle breeds in China.
abstract: The nucleophosmin (nucleolar phosphoprotein B23, numatrin) gene (NPM1, previously known as nucleophosmin/nucleoplasmin family, member 1) encodes a multifunctional nucleolar phosphoprotein that plays a crucial role in cell growth and homeostasis. Seven sequence variants (SVs) were identified in the coding region of bovine NPM1, five of which were in complete linkage disequilibrium. Eight different haplotypes were identified, of which two major haplotypes have a frequency of 23.2% and 20.4%. Three SVs were significantly associated with body weight in the Nanyang population as analysed at different ages. No significant association was detected between 18 combined genotypes and body weight at five different ages. Our results suggest that some polymorphisms in NPM1 are associated with body weight at some ages and may be used as candidates for marker-assisted selection and management in beef cattle breeding programmes.
authors: College of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling, Shaanxi 712100, China.
authors: Y Z
authors: YZ
authors: Huang
authors: H
authors: H
authors: He
authors: J
authors: J
authors: Wang
authors: Z J
authors: ZJ
authors: Li
authors: X Y
authors: XY
authors: Lan
authors: C Z
authors: CZ
authors: Lei
authors: E P
authors: EP
authors: Zhang
authors: C L
authors: CL
authors: Zhang
authors: J Q
authors: JQ
authors: Wang
authors: Q W
authors: QW
authors: Shen
authors: H
authors: H
authors: Chen
mesh_terms: D000818:Animals; D001835:Body Weight / Q000235:genetics*; D002417:Cattle / Q000235:genetics*; D002681:China; D056726:Genetic Association Studies; D006239:Haplotypes; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism*; D000090243:Nucleophosmin
chemical_list: D009687:Nuclear Proteins; D000090243:Nucleophosmin