title: [Synthesis and antitumor activity of betulin, erythrodiol and uvaol aminopropoxy derivatives].
abstract: The synthesis of aminopropoxy derivatives of betulin, erythrodiol, uvaol and oleantriol via cyanoethylation of triterpenoids hydroxyl groups and subsequent reduction of cyanoethyl fragments is described. High and specific in vitro antitumor activity (cytotoxicity) of 3beta,28-di-O-[3-(aminopropoxy)]lupa-20(29)-ene and 3beta-O-hydroxy-28-O-[3-(aminopropoxy)]olean-12-ene towards a wide range of human tumor cell lines is discovered. The aminopropoxy group is shown to be a new perspective pharmacophor group for design of anticancer agents on the basis of triterpenoids.
authors: O B
authors: OB
authors: Kazakova
authors: G V
authors: GV
authors: Giniiatullina
authors: G A
authors: GA
authors: Tolstikov
authors: I P
authors: IP
authors: Baĭkova
authors: L
authors: L
authors: Zaprutko
authors: G N
authors: GN
authors: Apryshko
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D014315:Triterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000094062:Betulinic Acid
chemical_list: D000970:Antineoplastic Agents; D009828:Oleanolic Acid; D014315:Triterpenes; C077953:erythrodiol; C002503:betulin; D000094062:Betulinic Acid; C013330:uvaol