title: A novel pH-sensitive (±)-α-tocopherol-5-fluorouracil adduct with antioxidant and anticancer properties.
abstract: A novel pH-sensitive (±)-α-tocopherol-5-fluorouracil (VE-5-FU) adduct with antioxidant and anticancer properties for antioxidant-based cancer chemoprevention was synthesized and utilized for selective drug release in the stomach.
authors: State Key Laboratory of Virology, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, PR China.
authors: Dong-Wei
authors: DW
authors: Li
authors: Fang-Fang
authors: FF
authors: Tian
authors: Yu-Shu
authors: YS
authors: Ge
authors: Xin-Liang
authors: XL
authors: Ding
authors: Jia-Han
authors: JH
authors: Li
authors: Zi-Qiang
authors: ZQ
authors: Xu
authors: Mei-Fang
authors: MF
authors: Zhang
authors: Xiao-Le
authors: XL
authors: Han
authors: Ran
authors: R
authors: Li
authors: Feng-Lei
authors: FL
authors: Jiang
authors: Yi
authors: Y
authors: Liu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D001665:Binding Sites; D049109:Cell Proliferation / Q000187:drug effects; D018890:Chemoprevention; D003198:Computer Simulation; D005472:Fluorouracil / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use / Q000633:toxicity; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009369:Neoplasms / Q000188:drug therapy; D012709:Serum Albumin / Q000737:chemistry; D013237:Stereoisomerism; D024505:Tocopherols / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D012709:Serum Albumin; C569354:alpha-tocopherol-5-fluorouracil; D024505:Tocopherols; D005472:Fluorouracil