title: New synthesis of spirocycles by utilizing in situ forming hypervalent iodine species.
abstract: A very effective spirocyclization procedure for installing nucleophiles (Nu = N(3), NO(2), SCN, SO(2)Tol, and halogens) via iodonium(III) salts has been developed using the combination of iodoarene and mCPBA. The high-yielding syntheses of the cyclohexadienone-type spirocyclic compounds 2 having varied functionalities in the skeletons have been achieved from the aryl alkynes 1 with the optimized bis(iodoarene) 3h.
authors: College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan.
authors: Toshifumi
authors: T
authors: Dohi
authors: Tomofumi
authors: T
authors: Nakae
authors: Yohei
authors: Y
authors: Ishikado
authors: Daishi
authors: D
authors: Kato
authors: Yasuyuki
authors: Y
authors: Kita
mesh_terms: D001386:Azides / Q000737:chemistry; D003500:Cyclization; D007455:Iodine / Q000737:chemistry*; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis*
chemical_list: D001386:Azides; D013141:Spiro Compounds; D007455:Iodine