title: Systems biology of infectious diseases: a focus on fungal infections.
abstract: The study of infectious disease concerns the interaction between the host species and a pathogen organism. The analysis of such complex systems is improving with the evolution of high-throughput technologies and advanced computational resources. This article reviews integrative, systems-oriented approaches to understanding mechanisms underlying infection, immune response and inflammation to find biomarkers of disease and design new drugs. We focus on the systems biology process, especially the data gathering and analysis techniques rather than the experimental technologies or latest computational resources.
authors: Departamento de Informática y Automática, University of Salamanca, Salamanca, Spain. rodri@usal.es
authors: Rodrigo
authors: R
authors: Santamaría
authors: Lisa
authors: L
authors: Rizzetto
authors: Michael
authors: M
authors: Bromley
authors: Teresa
authors: T
authors: Zelante
authors: Wanseon
authors: W
authors: Lee
authors: Duccio
authors: D
authors: Cavalieri
authors: Luigina
authors: L
authors: Romani
authors: Brian
authors: B
authors: Miller
authors: Ivo
authors: I
authors: Gut
authors: Manuel
authors: M
authors: Santos
authors: Philippe
authors: P
authors: Pierre
authors: Paul
authors: P
authors: Bowyer
authors: Misha
authors: M
authors: Kapushesky
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use; D001232:Aspergillus fumigatus / Q000187:drug effects / Q000235:genetics / Q000276:immunology*; D015415:Biomarkers / Q000032:analysis; D002176:Candida albicans / Q000187:drug effects / Q000235:genetics / Q000276:immunology*; D003141:Communicable Diseases / Q000188:drug therapy / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D016207:Cytokines / Q000276:immunology; D015195:Drug Design; D014644:Genetic Variation; D016681:Genome, Fungal; D054884:Host-Pathogen Interactions / Q000187:drug effects / Q000276:immunology; D006801:Humans; D057131:Immune Evasion; D007108:Immune Tolerance; D046228:Microarray Analysis; D058990:Molecular Targeted Therapy; D009181:Mycoses / Q000188:drug therapy / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D040901:Proteomics / Q000379:methods*; D051192:Receptors, Pattern Recognition / Q000235:genetics / Q000276:immunology; D049490:Systems Biology / Q000379:methods*; D018417:Th1 Cells / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology
chemical_list: D000935:Antifungal Agents; D015415:Biomarkers; D016207:Cytokines; D051192:Receptors, Pattern Recognition