title: Identification of factors associated with good response to growth hormone therapy in children with short stature: results from the ANSWER Program®.
abstract: OBJECTIVE
  To identify factors associated with growth in children on growth hormone (GH) therapy using data from the American Norditropin Studies: Web-enabled Research (ANSWER) Program® registry.
  
  
  METHODS
  GH-naïve children with GH deficiency, multiple pituitary hormone deficiency, idiopathic short stature, Turner syndrome, or a history of small for gestational age were eligible (N = 1,002). Using a longitudinal statistical approach, predictive factors were identified in patients with GHD for change from baseline in height standard deviation score (ΔHSDS) following 2 years of treatment.
  
  
  RESULTS
  Gradual increases in ΔHSDS over time were observed for all diagnostic categories. Significant predictive factors of ΔHSDS, ranked by significance were: height velocity (HV) at 4 months > baseline age > baseline HSDS > baseline body mass index (BMI) SDS > baseline insulin-like growth factor I (IGF-I) SDS; gender was not significant. HV at 4 months and baseline BMI SDS were positively correlated, whereas baseline age, HSDS, and IGF-I SDS were negatively correlated with ΔHSDS.
  
  
  CONCLUSIONS
  These results may help guide GH therapy based on pretreatment characteristics and early growth response.
authors: Department of Pediatrics, Milton S, Hershey Medical Center, Penn State College of Medicine, Hershey, PA, USA. plee@psu.edu.
authors: Peter A
authors: PA
authors: Lee
authors: John
authors: J
authors: Germak
authors: Robert
authors: R
authors: Gut
authors: Naum
authors: N
authors: Khutoryansky
authors: Judith
authors: J
authors: Ross