title: Evaluation of glomerular filtration rate by use of dynamic computed tomography and Patlak analysis in clinically normal cats.
abstract: OBJECTIVE
  To obtain quantitative variables of the abdominal aorta and both kidneys on the basis of time-attenuation curves (TACs) and to measure glomerular filtration rate (GFR) for each kidney and the global GFR in clinically normal cats by use of dynamic computed tomography (CT) and Patlak analysis.
  
  
  METHODS
  9 healthy cats.
  
  
  METHODS
  All the cats were anesthetized with propofol. Anesthesia was maintained by administration of isoflurane, and CT examination was performed in the anesthetized cats. The TACs and renal volume were measured by use of the baseline precontrast and single-slice dynamic scans. The CT-GFR of each kidney and the global CT-GFRs were calculated via Patlak plot analysis.
  
  
  RESULTS
  CT-GFR results from 7 cats were valid. Peak aortic enhancement was detected between 9.0 and 14.0 seconds after iohexol injection, and the initial peak time of renal parenchymal enhancement was 15 to 24 seconds after iohexol injection. Mean ± SD global GFR was 2.06 ± 0.62 mL/min/kg. Mean ± SD CT-GFR of the right and left kidneys was 0.97 ± 0.32 mL/min/kg and 1.05 ± 0.31 mL/min/kg, respectively.
  
  
  CONCLUSIONS
  The CT-GFR method can be rapidly and conveniently performed in clinically normal cats. This combined structural-functional approach provided physiologic and morphological information on the kidneys of cats.
authors: Department of Diagnostic Imaging, College of Veterinary Medicine, Chungnam National University, Daejeon, 305-764, South Korea.
authors: Jinhwa
authors: J
authors: Chang
authors: Sejoon
authors: S
authors: Ahn
authors: Sooyoung
authors: S
authors: Choi
authors: Heechun
authors: H
authors: Lee
authors: Dongwoo
authors: D
authors: Chang
authors: Hojung
authors: H
authors: Choi
authors: Youngwon
authors: Y
authors: Lee
mesh_terms: D000768:Anesthesia, General / Q000662:veterinary; D000818:Animals; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging* / Q000502:physiology; D002415:Cats / Q000502:physiology*; D003287:Contrast Media / Q000493:pharmacokinetics; D005919:Glomerular Filtration Rate / Q000662:veterinary*; D007472:Iohexol / Q000493:pharmacokinetics; D007668:Kidney / Q000000981:diagnostic imaging* / Q000502:physiology; D016014:Linear Models; D015742:Propofol / Q000494:pharmacology; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed / Q000379:methods* / Q000662:veterinary
chemical_list: D003287:Contrast Media; D007472:Iohexol; D015742:Propofol