title: miR-196a2 C allele is a low-penetrant risk factor for cancer development.
abstract: Published data on the association between miR-196a2 T/C polymorphism and cancer susceptibility are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 21 studies including 10,441 cases and 12,353 controls were involved in this meta-analysis. Overall, significantly elevated cancer risk was associated with miR-196a2 C allele when all studies were pooled into the meta-analysis (TC vs. TT: OR=1.23, 95% CI=1.11-1.36; CC vs. TT: OR=1.30, 95% CI=1.14-1.48; dominant model: OR=1.25, 95% CI=1.13-1.38). In the subgroup analysis by ethnicity, significantly increased risks were found in Asains (TC vs. TT: OR=1.24, 95% CI=1.10-1.40; CC vs. TT: OR=1.31, 95% CI=1.13-1.52; dominant model: OR=1.26, 95% CI=1.12-1.41) but with bordline statistical significance in Caucasians (TC vs. TT: OR=1.15, 95% CI=1.00-1.31). In the subgroup analysis by cancer type, statistically significantly increased risks were found for breast cancer (TC vs. TT: OR=1.15, 95% CI=1.01-1.31; CC vs. TT: OR=1.30, 95% CI=1.01-1.68; dominant model: OR=1.22, 95% CI=1.00-1.50; and recessive model: OR=1.11, 95% CI=1.01-1.23) and lung cancer (CC vs. TT: OR=1.30, 95% CI=1.10-1.54; and recessive model: OR=1.18, 95% CI=1.02-1.36). When stratified by study design, statistically significantly elevated risk was found in hospital-based studies (TC vs. TT: OR=1.30, 95% CI=1.13-1.49; CC vs. TT: OR=1.37, 95% CI=1.14-1.66; dominant model: OR=1.32, 95% CI=1.15-1.53) and population-based studies (CC vs. TT: OR=1.19, 95% CI=1.06-1.35; dominant model: OR=1.13, 95% CI=1.01-1.25). Despite some limitations, this meta-analysis suggests that the miR-196a2 C allele is a low-penetrant risk factor for cancer development.
authors: Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China. mdqiulixin@hotmail.com
authors: Li-Xin
authors: LX
authors: Qiu
authors: You
authors: Y
authors: Wang
authors: Zu-Guang
authors: ZG
authors: Xia
authors: Bo
authors: B
authors: Xi
authors: Chen
authors: C
authors: Mao
authors: Jia-Lei
authors: JL
authors: Wang
authors: Bi-Yun
authors: BY
authors: Wang
authors: Fang-Fang
authors: FF
authors: Lv
authors: Xiang-Hua
authors: XH
authors: Wu
authors: Ling-Qing
authors: LQ
authors: Hu
mesh_terms: D000483:Alleles; D020022:Genetic Predisposition to Disease; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D019683:Penetrance; D011230:Precancerous Conditions / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors
chemical_list: C542543:MIRN196 microRNA, human; D035683:MicroRNAs