title: Demonstration of safety in Alzheimer's patients for intervention with an anti-hypertensive drug Nilvadipine: results from a 6-week open label study.
abstract: BACKGROUND
  Nilvadipine may lower rates of conversion from mild-cognitive impairment to Alzheimer's disease (AD), in hypertensive patients. However, it remains to be determined whether treatment with nilvadipine is safe in AD patients, given the higher incidence of orthostatic hypotension (OH) in this population, who may be more likely to suffer from symptoms associated with the further exaggeration of a drop in BP.
  
  
  OBJECTIVE
  The aim of this study was to investigate the safety and tolerability of nilvadipine in AD patients.
  
  
  METHODS
  AD patients in the intervention group (n = 56) received nilvadipine 8  mg daily over 6-weeks, compared to the control group (n = 30) who received no intervention. Differences in systolic (SBP) and diastolic (DBP) blood pressure, before and after intervention, was assessed using automated sphygmomanometer readings and ambulatory BP monitors (ABP), and change in OH using a finometer. Reporting of adverse events was monitored throughout the study.
  
  
  RESULTS
  There was a significant reduction in the SBP of treated patients compared to non-treated patients but no significant change in DBP. Individuals with higher initial blood pressure (BP) had greater reduction in BP but individuals with normal BP did not experience much change in their BP. While OH was present in 84% of the patients, there was no further drop in BP recorded on active stand studies. There were no significant differences in adverse event reporting between groups.
  
  
  CONCLUSIONS
  Nilvadipine was well tolerated by patients with AD. This study supports further investigation of its efficacy as a potential treatment for AD.
authors: St. James Hospital, Dublin, Ireland. skennelly1976@hotmail.com
authors: S P
authors: SP
authors: Kennelly
authors: L
authors: L
authors: Abdullah
authors: D
authors: D
authors: Paris
authors: J
authors: J
authors: Parish
authors: V
authors: V
authors: Mathura
authors: M
authors: M
authors: Mullan
authors: F
authors: F
authors: Crawford
authors: B A
authors: BA
authors: Lawlor
authors: R A
authors: RA
authors: Kenny
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000188:drug therapy*; D000959:Antihypertensive Agents / Q000009:adverse effects*; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D000959:Antihypertensive Agents; C035100:nilvadipine; D009543:Nifedipine