title: [Consensus guidelines for diagnosis, treatment and follow-up of patients with gastrointestinal stromal tumors].
abstract: Gastrointestinal stromal tumors are the most common mesenchymal tumors in gastrointestinal tract. They are often asymptomatic and discovered incidentally during endoscopic or barium studies. About 80% GISTs have a KIT (CD 117 antigen) gene mutation. Most affect exon 11, less commonly exon 9,13 or 17, that results in uncontrolled KIT signaling. This led to effective systemic therapies in the form of small molecule inhibitors of the receptor tyrosine kinase such as imatinib mesylat. With the purpose of providing standardized approach to rational and effective diagnostic and treatment algorithm in Croatia, a multidisciplinary session was organized. Results of the session are given in the form of Consensus guidelines.
authors: Zavod za gastroenterologiju i hepatologiju, Klinika za unutarnje bolesti, Medicinski fakultet, Sveuriliite u Zagreb. nadan.rustemovic@zg.t-com.hr
authors: Nadan
authors: N
authors: Rustemović
authors: Jasminka
authors: J
authors: Jakić-Razumović
authors: Borislav
authors: B
authors: Belev
authors: Branka
authors: B
authors: Petricević
authors: Mate
authors: M
authors: Skegro
authors: Emil
authors: E
authors: Kinda
authors: Goran
authors: G
authors: Augustin
authors: Irena
authors: I
authors: Hrstić
authors: Rajko
authors: R
authors: Ostojić
authors: Ranka
authors: R
authors: Stern-Padovan
authors: Damir
authors: D
authors: Vrbanec
mesh_terms: D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D017410:Practice Guidelines as Topic