title: Examination of the performance of different pointwise linear regression progression criteria to detect glaucomatous visual field change.
abstract: BACKGROUND
  We aimed to investigate the performance of five different trend analysis criteria for the detection of glaucomatous progression and to determine the most frequently and rapidly progressing locations of the visual field.
  
  
  METHODS
  Retrospective cohort.
  
  
  METHODS
  Treated glaucoma patients with ≥ 8 Swedish Interactive Thresholding Algorithm (SITA)-standard 24-2 visual field tests.
  
  
  METHODS
  Progression was determined using trend analysis. Five different criteria were used: (A) ≥ 1 significantly progressing point; (B) ≥ 2 significantly progressing points; (C) ≥ 2 progressing points located in the same hemifield; (D) at least two adjacent progressing points located in the same hemifield; (E) ≥ 2 progressing points in the same Garway-Heath map sector.
  
  
  METHODS
  Number of progressing eyes and false-positive results.
  
  
  RESULTS
  We included 587 patients. The number of eyes reaching a progression end-point using each criterion was: A = 300 (51%); B = 212 (36%); C = 194 (33%); D = 170 (29%); and E = 186 (31%) (P ≤ 0.03). The numbers of eyes with positive slopes were: A = 13 (4.3%); B = 3 (1.4%); C = 3 (1.5%); D = 2 (1.1%); and E = 3 (1.6%) (P = 0.06). The global slopes for progressing eyes were more negative in Groups B, C and D than in Group A (P = 0.004). The visual field locations that progressed more often were those in the nasal field adjacent to the horizontal midline.
  
  
  CONCLUSIONS
  Pointwise linear regression criteria that take into account the retinal nerve fibre layer anatomy enhances the specificity of trend analysis for the detection glaucomatous visual field progression.
authors: Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, NY 10003, USA. demoraesmd@gmail.com
authors: Carlos G
authors: CG
authors: De Moraes
authors: Craig A
authors: CA
authors: Liebmann
authors: Remo
authors: R
authors: Susanna
authors: Robert
authors: R
authors: Ritch
authors: Jeffrey M
authors: JM
authors: Liebmann
mesh_terms: D000368:Aged; D000465:Algorithms; D018450:Disease Progression; D005189:False Positive Reactions; D005260:Female; D005901:Glaucoma / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D016014:Linear Models; D008297:Male; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D014786:Vision Disorders / Q000175:diagnosis* / Q000503:physiopathology; D014794:Visual Fields