title: Correlation between tumor measurement on Computed Tomography and resected specimen size in lung adenocarcinomas.
abstract: OBJECTIVE
  To compare preoperative size of stage I and stage II lung adenocarcinoma as measured by Computed Tomography (CT) and as assessed on gross pathology specimens.
  
  
  METHODS
  47 patients diagnosed with stage I or II lung adenocarcinoma were evaluated. Institutional Review Board permission was obtained. Tumor contours were delineated using a semi-automated segmentation algorithm and adjusted based on a radiologist's input. Based on the tumor perimeter, maximal in-plane tumor diameter was calculated automatically. The largest single diameter from the pathology gross report was utilized. A paired t-test was used to examine the measurement difference between CT and pathology.
  
  
  RESULTS
  The mean largest diameter of the tumors at CT and pathology was 29.53 mm and 24.04 mm, respectively. There was a statistically significant difference between the mean CT measurement and mean pathology measurement of 5.49 mm (standard deviation 9.08 mm, p<0.001). The percent relative difference between the two measurements was 18.3% (standard deviation 28.2%).
  
  
  CONCLUSIONS
  There is a statistically significant difference between the tumor diameter as measured by CT and on pathology gross specimen. These differences could have implications in the treatment and prognosis of patients with early stage lung adenocarcinoma.
authors: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
authors: Katharine
authors: K
authors: Lampen-Sachar
authors: Binsheng
authors: B
authors: Zhao
authors: Junting
authors: J
authors: Zheng
authors: Chaya S
authors: CS
authors: Moskowitz
authors: Lawrence H
authors: LH
authors: Schwartz
authors: Maureen F
authors: MF
authors: Zakowski
authors: Naiyer A
authors: NA
authors: Rizvi
authors: Mark G
authors: MG
authors: Kris
authors: Michelle S
authors: MS
authors: Ginsberg
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D000077192:Adenocarcinoma of Lung; D000465:Algorithms; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D009367:Neoplasm Staging; D014057:Tomography, X-Ray Computed