title: The mitochondrial cascade hypothesis for Parkinson's disease.
abstract: During the past decades, we have witnessed significant advances in our understanding of the molecular etiology of Parkinson's disease (PD). The unearthing of the causative genes for hereditary PD accelerated not only the studies of the molecular mechanisms underlying this pathology, but also set mitochondria at the center of PD pathology. In this review we revisit mitochondrial key role and propose a hypothesis for PD, that allows the unification of both sporadic and familial PD forms. In light of this we also discuss new promising disease-modified therapies.
authors: Center for Neuroscience and Cell Biology, University of Coimbra, Portugal. smacardoso@yahoo.com
authors: Sandra M
authors: SM
authors: Cardoso
mesh_terms: D002491:Central Nervous System Agents / Q000627:therapeutic use; D004272:DNA, Mitochondrial / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D010300:Parkinson Disease / Q000188:drug therapy / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D002491:Central Nervous System Agents; D004272:DNA, Mitochondrial