title: Exercise as migraine prophylaxis: a randomized study using relaxation and topiramate as controls.
abstract: OBJECTIVE
  Scientific evidence regarding exercise in migraine prophylaxis is required. Therefore this study aimed to evaluate the effects of exercise in migraine prevention.
  
  
  METHODS
  In a randomized, controlled trial of adults with migraine, exercising for 40 minutes three times a week was compared to relaxation according to a recorded programme or daily topiramate use, which was slowly increased to the individual's highest tolerable dose (maximum 200 mg/day). The treatment period lasted for 3 months, and migraine status, quality of life, level of physical activity, and oxygen uptake were evaluated. The primary efficacy variable was the mean reduction of the frequency of migraine attacks during the final month of treatment compared with the baseline.
  
  
  RESULTS
  Ninety-one patients were randomized and included in the intention-to-treat analysis. The primary efficacy variable showed a mean reduction of 0.93 (95% confidence interval (CI) 0.31-1.54) attacks in the exercise group, 0.83 (95% CI 0.22-1.45) attacks in the relaxation group, and 0.97 (95% CI 0.36-1.58) attacks in the topiramate group. No significant difference was observed between the groups (p = 0.95).
  
  
  CONCLUSIONS
  Exercise may be an option for the prophylactic treatment of migraine in patients who do not benefit from or do not want to take daily medication.
authors: University of Gothenburg, Sweden. emma.varkey@neuro.gu.se
authors: Emma
authors: E
authors: Varkey
authors: Asa
authors: A
authors: Cider
authors: Jane
authors: J
authors: Carlsson
authors: Mattias
authors: M
authors: Linde
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D005632:Fructose / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy / Q000517:prevention & control*; D009043:Motor Activity / Q000502:physiology; D010100:Oxygen / Q000378:metabolism; D011446:Prospective Studies; D011788:Quality of Life; D012064:Relaxation Therapy / Q000379:methods*; D000077236:Topiramate; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose; D010100:Oxygen