title: Overexpression of Y-box binding protein-1 in cervical cancer and its association with the pathological response rate to chemoradiotherapy.
abstract: The aim of this study was to evaluate the expression of Y-box binding protein-1 (YB-1) in nonneoplastic cervical tissue and cervical cancer tissue and to evaluate its relationship with chemoradiosensitivity in the cases of cervical cancer. We performed immunohistochemical studies to examine YB-1 expression among 59 patients with cervical cancer, 30 with cervical intraepithelial neoplasia (CIN), and 30 with cervicitis. The mean YB-1 histological score(HSCORE)values for cervicitis, cervical CIN, and cervical cancer tissues were 22.3, 39, and 84.4, respectively. The mean YB-1 HSCORE value was 80.0 for cervical cancer patients who showed complete pathological response to chemoradiotherapy and 144.3 for cervical cancer patients who showed partial pathological response. Our data showed that the YB-1 expression was the highest in cervical cancer tissue, followed by cervical CIN tissue, and then cervicitis tissues. High YB-1 expression resulted in a lower pathological response rate in patients of cervical cancer than low YB-1 expression did. Our results implied that YB-1 may play a role in the genesis of cervical cancer and that high YB-1 expression decreases the chemoradiosensitivity of cervical cancers.
authors: Department of Oncology, Mian Yang Central Hospital, Mian Yang, Sichuan 621000, People's Republic of China.
authors: Y
authors: Y
authors: Zhang
authors: S R
authors: SR
authors: Reng
authors: L
authors: L
authors: Wang
authors: L
authors: L
authors: Lu
authors: Z H
authors: ZH
authors: Zhao
authors: Z K
authors: ZK
authors: Zhang
authors: X D
authors: XD
authors: Feng
authors: X D
authors: XD
authors: Ding
authors: J
authors: J
authors: Wang
authors: G
authors: G
authors: Feng
authors: T Z
authors: TZ
authors: Dai
authors: J
authors: J
authors: Pu
authors: X B
authors: XB
authors: Du
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D059248:Chemoradiotherapy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009367:Neoplasm Staging; D015854:Up-Regulation; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000628:therapy; D002575:Uterine Cervicitis / Q000378:metabolism / Q000473:pathology; D051840:Y-Box-Binding Protein 1 / Q000032:analysis / Q000096:biosynthesis*; D002578:Uterine Cervical Dysplasia / Q000378:metabolism* / Q000473:pathology* / Q000628:therapy
chemical_list: D014408:Biomarkers, Tumor; D051840:Y-Box-Binding Protein 1; C070856:YBX1 protein, human