title: Is rheumatoid arthritis a risk factor for oral bisphosphonate-induced osteonecrosis of the jaws?
abstract: Bisphosphonate-related osteonecrosis of the jaws is a relevant side-effect of these drugs that has been generating a great concern through increasing reports, worldwide, of this bone necrosis. Among several BRONJ hypothetical co-factors that could play a role in BRONJ pathogenesis, rheumatoid arthritis (RA) has been included as a relevant risk factor for BRONJ; however, until now the relationship between these diseases has not been fully explained. Thus, the purpose of this paper is to establish hypothetical factors that could link these two diseases, considering mainly inflammatory components and the organism effects of medicines used to treat RA, particularly steroids and methotrexate (MTX).
authors: UNESP-Univ. of Estadual Paulista, Araraquara Dental School, Department of Periodontology, Araraquara, São Paulo, Brazil. conteneto@hotmail.com
authors: Nicolau
authors: N
authors: Conte Neto
authors: Alliny de Souza
authors: AS
authors: Bastos
authors: Rosemary Adriana
authors: RA
authors: Chierici-Marcantonio
authors: Elcio
authors: E
authors: Marcantonio
mesh_terms: D000284:Administration, Oral; D001172:Arthritis, Rheumatoid / Q000150:complications*; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000150:complications*; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008962:Models, Theoretical; D012307:Risk Factors
chemical_list: D050071:Bone Density Conservation Agents