title: Factors associated with recurrence within 2 years after curative surgery for gastric adenocarcinoma.
abstract: BACKGROUND
  Despite curative surgery for gastric cancer, many patients die of recurrent cancer. Few studies have investigated the time to recurrence after curative resection for gastric cancer.
  
  
  METHODS
  Data were collected prospectively between December 1987 and December 2006. A total of 1,549 patients underwent curative resection of adenocarcinoma of the stomach at Taipei Veterans General Hospital. Among them, 419 patients had recurrence; they were divided into early recurrence (<2 years) and late recurrence (≥2 years). The clinicopathological characteristics, survival time after recurrence, and recurrence patterns were compared between the two groups.
  
  
  RESULTS
  Multivariate analysis showed that stage III gastric cancer patients with early recurrence had larger tumors and more lymph node metastasis than patients with late recurrence, while no difference between early and late recurrence was observed in stage I and II patients. Early recurrence was associated with more distant metastasis than was late recurrence. Patients with advanced TNM stage tended to die within 2 years after recurrence.
  
  
  CONCLUSIONS
  Gastric cancer patients with larger tumors and more lymph node metastasis tended to have early recurrence, especially stage III patients. Advanced TNM stage was associated with early cancer death after recurrence.
authors: Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, 201 Section 2 Shih-Pai Road, Taipei, 11217, Taiwan.
authors: Cheng-Yu
authors: CY
authors: Chiang
authors: Kuo-Hung
authors: KH
authors: Huang
authors: Wen-Liang
authors: WL
authors: Fang
authors: Chew-Wun
authors: CW
authors: Wu
authors: Jen-Hao
authors: JH
authors: Chen
authors: Su-Shin
authors: SS
authors: Lo
authors: Mao-Chih
authors: MC
authors: Hsieh
authors: King-Han
authors: KH
authors: Shen
authors: Anna Fen-Yau
authors: AF
authors: Li
authors: Dau-Ming
authors: DM
authors: Niu
authors: Shih-Hwa
authors: SH
authors: Chiou
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000401:mortality; D009367:Neoplasm Staging; D011446:Prospective Studies; D012008:Recurrence; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D013997:Time Factors