title: Effect of aerobic exercise on insulin, insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in overweight and obese postmenopausal women.
abstract: OBJECTIVE
  The purpose of presented study was to verify the influence of aerobic physical activity program on the serum insulin, insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) concentrations in overweight and obese postmenopausal women.
  
  
  METHODS
  Somatic parameters and serum concentrations of insulin, IGF-1 and IGFBP-3 were measured in 21 overweight and obese women, before and after 8-week cycloergometer physical workout and 16 age-matched, controls. Age of all studied women ranged from 54 to 78 years.
  
  
  RESULTS
  The comparative analysis of biochemical indices measured before and after the training program showed that the systematic exercise cause the significant decrease in insulin (P<0.05) and IGF-1 concentrations (P<0.05). There were no differences in these parameters in controls over the studied period. The level of IGFBP-3 was not significantly changed in both investigated groups. In women participating in the training program the positive correlation (P<0.05) between changes in IGF-1 levels (Δ) and changes in insulin concentrations (Δ) within two terms of the study were found. The magnitude of changes (Δ) in insulin and IGF-1 levels over the study period correlated with their concentrations measured before the training program (P<0.01).
  
  
  CONCLUSIONS
  Results of the present study indicate that regular aerobic physical activity decreases serum insulin and IGF-1 levels in postmenopausal women. The magnitude of insulin and IGF-1 concentration changes depend on their initial levels. Changes of IGF-1 levels are associated with insulin concentration modifications.
authors: Biochemistry and Hygiene, University School of Physical Education, Poznań, Poland.
authors: A
authors: A
authors: Wieczorek-Baranowska
authors: A
authors: A
authors: Nowak
authors: E
authors: E
authors: Michalak
authors: J
authors: J
authors: Karolkiewicz
authors: B
authors: B
authors: Pospieszna
authors: R
authors: R
authors: Rutkowski
authors: M
authors: M
authors: Laurentowska
authors: L
authors: L
authors: Pilaczyńska-Szcześniak
mesh_terms: D000368:Aged; D015992:Body Mass Index; D016022:Case-Control Studies; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000503:physiopathology; D050177:Overweight / Q000097:blood* / Q000503:physiopathology; D017698:Postmenopause / Q000097:blood* / Q000502:physiology; D018709:Statistics, Nonparametric
chemical_list: D007328:Insulin; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I