title: Blimp1 regulates the transition of neonatal to adult intestinal epithelium.
abstract: In many mammalian species, the intestinal epithelium undergoes major changes that allow a dietary transition from mother's milk to the adult diet at the end of the suckling period. These complex developmental changes are the result of a genetic programme intrinsic to the gut tube, but its regulators have not been identified. Here we show that transcriptional repressor B lymphocyte-induced maturation protein 1 (Blimp1) is highly expressed in the developing and postnatal intestinal epithelium until the suckling to weaning transition. Intestine-specific deletion of Blimp1 results in growth retardation and excessive neonatal mortality. Mutant mice lack all of the typical epithelial features of the suckling period and are born with features of an adult-like intestine. We conclude that the suckling to weaning transition is regulated by a single transcriptional repressor that delays epithelial maturation.
authors: Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands.
authors: Vanesa
authors: V
authors: Muncan
authors: Jarom
authors: J
authors: Heijmans
authors: Stephen D
authors: SD
authors: Krasinski
authors: Nikè V
authors: NV
authors: Büller
authors: Manon E
authors: ME
authors: Wildenberg
authors: Sander
authors: S
authors: Meisner
authors: Marijana
authors: M
authors: Radonjic
authors: Kelly A
authors: KA
authors: Stapleton
authors: Wout H
authors: WH
authors: Lamers
authors: Izak
authors: I
authors: Biemond
authors: Marius A
authors: MA
authors: van den Bergh Weerman
authors: Dónal
authors: D
authors: O'Carroll
authors: James C
authors: JC
authors: Hardwick
authors: Daniel W
authors: DW
authors: Hommes
authors: Gijs R
authors: GR
authors: van den Brink
mesh_terms: D000818:Animals; D005260:Female; D018507:Gene Expression Regulation, Developmental; D007413:Intestinal Mucosa / Q000254:growth & development* / Q000378:metabolism*; D008297:Male; D051379:Mice / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D018345:Mice, Knockout; D008822:Mice, Transgenic; D000074462:Positive Regulatory Domain I-Binding Factor 1; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: C513258:Prdm1 protein, mouse; D014157:Transcription Factors; D000074462:Positive Regulatory Domain I-Binding Factor 1