title: Lung cancer signatures in plasma based on proteome profiling of mouse tumor models.
abstract: We investigated the potential of in-depth quantitative proteomics to reveal plasma protein signatures that reflect lung tumor biology. We compared plasma protein profiles of four mouse models of lung cancer with profiles of models of pancreatic, ovarian, colon, prostate, and breast cancer and two models of inflammation. A protein signature for Titf1/Nkx2-1, a known lineage-survival oncogene in lung cancer, was found in plasmas of mouse models of lung adenocarcinoma. An EGFR signature was found in plasma of an EGFR mutant model, and a distinct plasma signature related to neuroendocrine development was uncovered in the small-cell lung cancer model. We demonstrate relevance to human lung cancer of the protein signatures identified on the basis of mouse models.
authors: Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
authors: Ayumu
authors: A
authors: Taguchi
authors: Katerina
authors: K
authors: Politi
authors: Sharon J
authors: SJ
authors: Pitteri
authors: William W
authors: WW
authors: Lockwood
authors: Vitor M
authors: VM
authors: Faça
authors: Karen
authors: K
authors: Kelly-Spratt
authors: Chee-Hong
authors: CH
authors: Wong
authors: Qing
authors: Q
authors: Zhang
authors: Alice
authors: A
authors: Chin
authors: Kwon-Sik
authors: KS
authors: Park
authors: Gary
authors: G
authors: Goodman
authors: Adi F
authors: AF
authors: Gazdar
authors: Julien
authors: J
authors: Sage
authors: Daniela M
authors: DM
authors: Dinulescu
authors: Raju
authors: R
authors: Kucherlapati
authors: Ronald A
authors: RA
authors: Depinho
authors: Christopher J
authors: CJ
authors: Kemp
authors: Harold E
authors: HE
authors: Varmus
authors: Samir M
authors: SM
authors: Hanash
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000188:drug therapy / Q000235:genetics; D000077192:Adenocarcinoma of Lung; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood*; D001798:Blood Proteins / Q000235:genetics; D045744:Cell Line, Tumor; D004797:Enzyme-Linked Immunosorbent Assay; D066246:ErbB Receptors / Q000097:blood* / Q000235:genetics; D000069347:Erlotinib Hydrochloride; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000188:drug therapy / Q000235:genetics; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D008875:Middle Aged; D008969:Molecular Sequence Data; D055099:Neuroendocrine Cells / Q000166:cytology; D009687:Nuclear Proteins / Q000097:blood* / Q000235:genetics; D011506:Proteins / Q000235:genetics; D020543:Proteome; D040901:Proteomics; D011799:Quinazolines / Q000008:administration & dosage / Q000627:therapeutic use; D034622:RNA Interference; D034741:RNA, Small Interfering; D055752:Small Cell Lung Carcinoma / Q000097:blood* / Q000188:drug therapy / Q000235:genetics; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors / Q000097:blood* / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D001798:Blood Proteins; C000614412:NKX2-1 protein, human; C000614414:Nkx2-1 protein, mouse; D009687:Nuclear Proteins; D011506:Proteins; D020543:Proteome; D011799:Quinazolines; D034741:RNA, Small Interfering; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors; D000069347:Erlotinib Hydrochloride; D066246:ErbB Receptors