title: Pseudoguaianolides and guaianolides from Inula hupehensis as potential anti-inflammatory agents.
abstract: Eight new pseudoguaianolides (1-8), two new guaianolides (9 and 10), and 14 known sesquiterpenes were isolated from the aerial parts of Inula hupehensis. The structures were elucidated using spectroscopic methods and circular dichroism analysis. All compounds were tested for inhibitory activities against LPS-induced nitric oxide production in RAW264.7 macrophages. Compounds 13 and 22 were found to inhibit nitric oxide production potently, with IC50 values of 0.9 and 0.6 μM, respectively. Preliminary structure-activity relationships for these compounds are proposed.
authors: School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.
authors: Jiang-Jiang
authors: JJ
authors: Qin
authors: Jia-Xian
authors: JX
authors: Zhu
authors: Qi
authors: Q
authors: Zeng
authors: Xiang-Rong
authors: XR
authors: Cheng
authors: Yan
authors: Y
authors: Zhu
authors: Shou-De
authors: SD
authors: Zhang
authors: Lei
authors: L
authors: Shan
authors: Hui-Zi
authors: HZ
authors: Jin
authors: Wei-Dong
authors: WD
authors: Zhang
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D038143:Inula / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D045789:Sesquiterpenes, Guaiane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: C562146:2alpha-acetoxy-4alpha,6alpha-dihydroxy-1beta,5alphaH-guai-9(10),11(13)-dien-12,8alpha-olide; C562145:4beta,10alpha-dihydroxy-5alphaH-guai-1(2),11(13)-dien-12,8alpha-olide; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; D008070:Lipopolysaccharides; D045789:Sesquiterpenes, Guaiane; D009569:Nitric Oxide