title: Beneficial nutraceutical modulation of cerebral erythropoietin expression and oxidative stress: an experimental study.
abstract: The main object of this study is to examine the effect of Klamin®, a nutraceutical containing phenylethylamine, phycocyanins, mycosporine-like aminoacids and aphanizomenon flos aquae-phytochrome on the learning and memory ability, the oxidative status and cerebral erythropoietin and its receptor EPO/EPOR system in prematurely senescent (PS) mice. A total of 28 PS mice, selected according to a prior T-maze test, and 26 non-prematurely senescent mice (NPS) mice were chosen. PS animals were divided into 3 groups and followed for 4 weeks: A) normal chow diet; B) added with Klamin® at 20 mg/kg/day (low dose); C) added with Klamin® at 100mg/kg/day (high dose). A further group of NPS mice given either normal food (group D) or high dose Klamin® (group E) was also considered. The behavioral procedures of spatial learning ability (Morris test) showed that PS mice had significantly longer learning time as compared to their NPS counterpart (p<0.01), but this effect was prevented especially in mice supplemented with high-dose Klamin® (p<0.05) which improved performances in NPS mice (p<0.05). High-dose Klamin® supplementation restored the depleted total thiol concentration in the brain observed in PS mice while normalizing their increased malonildialdehyde level (p<0.05). Moreover, the high-dosage only caused a significant upregulation of EPO/EPOR system both in PS and in NPS animals (p<0.05). Taken together, these data suggest that this specific alga Klamath extract has considerable antioxidant and adaptogenic properties, also through a stimulatory effect of cerebral EPO/EPO system.
authors: Bio-Cell Unit Lab and Analysis Center, Miyazaki, Japan.
authors: S
authors: S
authors: Sedriep
authors: X
authors: X
authors: Xia
authors: F
authors: F
authors: Marotta
authors: L
authors: L
authors: Zhou
authors: H
authors: H
authors: Yadav
authors: H
authors: H
authors: Yang
authors: V
authors: V
authors: Soresi
authors: R
authors: R
authors: Catanzaro
authors: K
authors: K
authors: Zhong
authors: A
authors: A
authors: Polimeni
authors: D H
authors: DH
authors: Chui
mesh_terms: D000284:Administration, Oral; D000375:Aging / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D015153:Blotting, Western; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D019587:Dietary Supplements; D004921:Erythropoietin / Q000096:biosynthesis* / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D018782:Maze Learning / Q000187:drug effects*; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D023421:Models, Animal; D018384:Oxidative Stress / Q000187:drug effects; D010627:Phenethylamines / Q000494:pharmacology; D010798:Phycocyanin / Q000494:pharmacology; D010834:Phytochrome / Q000494:pharmacology; D017467:Receptors, Erythropoietin / Q000032:analysis / Q000096:biosynthesis*; D013438:Sulfhydryl Compounds / Q000032:analysis; D015854:Up-Regulation
chemical_list: D000975:Antioxidants; D010627:Phenethylamines; D017467:Receptors, Erythropoietin; D013438:Sulfhydryl Compounds; D010798:Phycocyanin; D004921:Erythropoietin; D010834:Phytochrome; D008315:Malondialdehyde