title: Oxaliplatin for metastatic colon cancer in a patient with renal failure.
abstract: OBJECTIVE
  Oxaliplatin, a key part of the standard regimen for colorectal cancer in Western countries, has become available in Japan. In a hemodialysis patient with cecal cancer, we investigated the efficacy, safety, pharmacokinetics, and dialysability of oxaliplatin.
  
  
  METHODS
  A 65-year-old man who had cecal cancer was treated with oxaliplatin (40 mg/m(2)) and l-leucovorin(l-LV) (200 mg/m(2)), which were administered simultaneously over 120 min via the side and main arms of a Y-tube, respectively. Then 5-FU (400 mg/m(2)) was administered rapidly via the side tube, followed by 5-FU (2,000 mg/m(2)) over 46 hours via the main tube. The patient had chronic renal failure due to diabetic nephropathy and hemodialysis was performed 3 times a week. Blood samples were collected from the dialyzer before and after each hemodialysis session to examine platinum clearance.
  
  
  RESULTS
  The patient received 3 courses of oxaliplatin before he died of cancer. During hemodialysis, the platinum level fell from 0.32 μg/mL to 0.15 μg/mL.
  
  
  CONCLUSIONS
  Since patients with renal failure have various associated disorders and oxaliplatin has a long half-life, it is necessary to obtain more pharmacokinetic data to investigate its accumulation and dialysability during long-term treatment. Such data will assist in treating the rapidly increasing number of hemodialysis patients with colorectal cancer.
authors: Third Department of Surgery, Tokyo Medical University, 6-7-1, Nishi-Shinjuku, Shinjuku, Tokyo, Japan 160-0023.
authors: Kenji
authors: K
authors: Katsumata
authors: Tetsuo
authors: T
authors: Sumi
authors: Tatehiko
authors: T
authors: Wada
authors: Yasuharu
authors: Y
authors: Mori
authors: Masayuki
authors: M
authors: Hisada
authors: Hideaki
authors: H
authors: Kawakita
authors: Masanori
authors: M
authors: Enomoto
authors: Shoji
authors: S
authors: Suzuki
authors: Daisuke
authors: D
authors: Matsuda
authors: Akihiko
authors: A
authors: Tsuchida
authors: Tatsuya
authors: T
authors: Aoki