title: Does oxidative stress play a role in altered plasma protein homeostasis in pregnancy-induced hypertension?
abstract: BACKGROUND
  Pregnancy-induced hypertension (PIH) is associated with oxidative stress and low plasma proteins. This study explored the effect of oxidative stress on plasma protein level in PIH.
  
  
  METHODS
  Serum total proteins (TP), albumin, globulin, malondialdehyde, protein carbonyls (PC) and protein bound sialic acid (PBSA) were measured in gestational hypertensive, pre-eclamptic, eclamptic and healthy pregnant women (n=20/group). Serum proteins were separated by electrophoresis for assessing protein damage.
  
  
  RESULTS
  Serum TP and albumin decreased and malondialdehyde, PC & PBSA increased significantly in all PIH subgroups as compared to healthy pregnant subjects. Serum globulin levels decreased only in eclampsia. Malondialdehyde and PC negatively correlated with albumin level. Protein fragmentation and aggregation in eclampsia were evident from electrophoretogram.
  
  
  CONCLUSIONS
  We conclude that oxidative damages to proteins contribute to decreased serum protein levels in PIH and hypersialylation of plasma proteins is probably body’s protective mechanism to combat oxidative protein damage in PIH.
authors: Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education & Research Institute, Puducherry, India.
authors: S
authors: S
authors: Asmathulla
authors: Bidhan Chandra
authors: BC
authors: Koner
authors: D
authors: D
authors: Papa
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001798:Blood Proteins / Q000378:metabolism*; D016022:Case-Control Studies; D004461:Eclampsia / Q000097:blood; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006706:Homeostasis; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood*; D007194:India; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000097:blood; D011247:Pregnancy; D050050:Protein Carbonylation; D012709:Serum Albumin / Q000378:metabolism; D012712:Serum Globulins / Q000378:metabolism; D055815:Young Adult
chemical_list: D001798:Blood Proteins; D012709:Serum Albumin; D012712:Serum Globulins; D008315:Malondialdehyde