title: Topiramate and visual loss in a patient carrying a Leber hereditary optic neuropathy mutation.
abstract: We describe a 43-year-old patient who experienced visual loss 4 years after beginning antiepileptic therapy with topiramate. Ophthalmological and neurological examinations led to a preliminary diagnosis of bilateral toxic optic neuritis. Mitochondrial genome sequence analysis detected a Leber hereditary optic neuropathy 11778G>A mutation. The possibility that topiramate might favor a conversion disease, alerts physicians to seek a history of blindness in patients undergoing chronic antiepileptic therapy.
authors: UOC Neurology and Neurophysiopathology, Ospedale Sandro Pertini, Via Monti Tiburtini 385, 00157 Rome, Italy. r.steno@libero.it
authors: Steno
authors: S
authors: Rinalduzzi
authors: Anna Maria
authors: AM
authors: Cipriani
authors: Neri
authors: N
authors: Accornero
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D001766:Blindness / Q000139:chemically induced* / Q000235:genetics; D004827:Epilepsy / Q000188:drug therapy / Q000235:genetics; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D009154:Mutation; D029242:Optic Atrophy, Hereditary, Leber / Q000150:complications* / Q000235:genetics; D000077236:Topiramate; D014794:Visual Fields / Q000187:drug effects
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose