title: Mycobacterium chelonae-abscessus complex associated with sinopulmonary disease, Northeastern USA.
abstract: Members of the Mycobacterium chelonae-abscessus complex represent Mycobacterium species that cause invasive infections in immunocompetent and immunocompromised hosts. We report the detection of a new pathogen that had been misidentified as M. chelonae with an atypical antimicrobial drug susceptibility profile. The discovery prompted a multicenter investigation of 26 patients. Almost all patients were from the northeastern United States, and most had underlying sinus or pulmonary disease. Infected patients had clinical features similar to those with M. abscessus infections. Taxonomically, the new pathogen shared molecular identity with members of the M. chelonae-abscessus complex. Multilocus DNA target sequencing, DNA-DNA hybridization, and deep multilocus sequencing (43 full-length genes) support a new taxon for these microorganisms. Because most isolates originated in Pennsylvania, we propose the name M. franklinii sp. nov. This investigation underscores the need for accurate identification of Mycobacterium spp. to detect new pathogens implicated in human disease.
authors: Associated Regional and University Pathologists Institute for Clinical and Experimental Pathology, Salt Lake City, UT 84108, USA. ke.monk@gmail.com
authors: Keith E
authors: KE
authors: Simmon
authors: Barbara A
authors: BA
authors: Brown-Elliott
authors: Perry G
authors: PG
authors: Ridge
authors: Jacob D
authors: JD
authors: Durtschi
authors: Linda Bridge
authors: LB
authors: Mann
authors: E Susan
authors: ES
authors: Slechta
authors: Arnold G
authors: AG
authors: Steigerwalt
authors: Benjamin D
authors: BD
authors: Moser
authors: Anne M
authors: AM
authors: Whitney
authors: June M
authors: JM
authors: Brown
authors: Karl V
authors: KV
authors: Voelkerding
authors: Karin L
authors: KL
authors: McGowan
authors: Anne F
authors: AF
authors: Reilly
authors: Thomas J
authors: TJ
authors: Kirn
authors: W Ray
authors: WR
authors: Butler
authors: Paul H
authors: PH
authors: Edelstein
authors: Richard J
authors: RJ
authors: Wallace
authors: Cathy A
authors: CA
authors: Petti
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics; D018834:Chaperonin 60 / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000235:genetics; D005260:Female; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D058885:Multilocus Sequence Typing; D009165:Mycobacterium Infections, Nontuberculous / Q000175:diagnosis / Q000382:microbiology*; D016926:Mycobacterium chelonae / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification; D009170:Nontuberculous Mycobacteria / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification*; D010414:Pennsylvania; D010802:Phylogeny; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D012141:Respiratory Tract Infections / Q000175:diagnosis / Q000382:microbiology*; D012852:Sinusitis / Q000175:diagnosis / Q000382:microbiology*; D013482:Superoxide Dismutase / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D018834:Chaperonin 60; D021903:DNA, Ribosomal Spacer; D012336:RNA, Ribosomal, 16S; C074119:heat-shock protein 65, Mycobacterium; C095500:SodA protein, Bacteria; D013482:Superoxide Dismutase