title: Whole grain products, fish and bilberries alter glucose and lipid metabolism in a randomized, controlled trial: the Sysdimet study.
abstract: BACKGROUND
  Due to the growing prevalence of type 2 diabetes, new dietary solutions are needed to help improve glucose and lipid metabolism in persons at high risk of developing the disease. Herein we investigated the effects of low-insulin-response grain products, fatty fish, and berries on glucose metabolism and plasma lipidomic profiles in persons with impaired glucose metabolism.
  
  
  RESULTS
  Altogether 106 men and women with impaired glucose metabolism and with at least two other features of the metabolic syndrome were included in a 12-week parallel dietary intervention. The participants were randomized into three diet intervention groups: (1) whole grain and low postprandial insulin response grain products, fatty fish three times a week, and bilberries three portions per day (HealthyDiet group), (2) Whole grain enriched diet (WGED) group, which includes principally the same grain products as group (1), but with no change in fish or berry consumption, and (3) refined wheat breads (Control). Oral glucose tolerance, plasma fatty acids and lipidomic profiles were measured before and after the intervention. Self-reported compliance with the diets was good and the body weight remained constant. Within the HealthyDiet group two hour glucose concentration and area-under-the-curve for glucose decreased and plasma proportion of (n-3) long-chain PUFAs increased (False Discovery Rate p-values <0.05). Increases in eicosapentaenoic acid and docosahexaenoic acid associated curvilinearly with the improved insulin secretion and glucose disposal. Among the 364 characterized lipids, 25 changed significantly in the HealthyDiet group, including multiple triglycerides incorporating the long chain (n-3) PUFA.
  
  
  CONCLUSIONS
  The results suggest that the diet rich in whole grain and low insulin response grain products, bilberries, and fatty fish improve glucose metabolism and alter the lipidomic profile. Therefore, such a diet may have a beneficial effect in the efforts to prevent type 2 diabetes in high risk persons.
  
  
  BACKGROUND
  ClinicalTrials.gov NCT00573781.
authors: VTT Technical Research Centre of Finland, Kuopio, Finland. Maria.Lankinen@vtt.fi
authors: Maria
authors: M
authors: Lankinen
authors: Ursula
authors: U
authors: Schwab
authors: Marjukka
authors: M
authors: Kolehmainen
authors: Jussi
authors: J
authors: Paananen
authors: Kaisa
authors: K
authors: Poutanen
authors: Hannu
authors: H
authors: Mykkänen
authors: Tuulikki
authors: T
authors: Seppänen-Laakso
authors: Helena
authors: H
authors: Gylling
authors: Matti
authors: M
authors: Uusitupa
authors: Matej
authors: M
authors: Orešič
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control; D002523:Edible Grain; D015525:Fatty Acids, Omega-3; D005260:Female; D005396:Fish Products; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D029800:Vaccinium myrtillus
chemical_list: D001786:Blood Glucose; D015525:Fatty Acids, Omega-3