title: The high mitotic count detected by phospho-histone H3 immunostain does not alter the benign behavior of angiocentric glioma.
abstract: Angiocentric glioma (AG) has been formally codified in the revised 2007 WHO Classification of Tumours of the Central Nervous System. AGs characteristically exhibit mixed features of ependymal and diffuse astrocytic differentiation and low proliferation rates, with Ki-67 labeling indices ranging from less than 1 to 5%. A single case with anaplastic recurrence and a labeling index of 10% has been reported. In the present study, we report a series of three AGs (Case 1: 4-year-old girl at right frontal lobe; Case 2: 4-year-old boy at left frontal lobe; Case 3: 9-year-old boy at right temporal lobe). Case 1 with elevated proliferation index (~10%) and increased mitotic activity (six mitoses per 10 high-power fields) on phospho-histone H3 (pHH3) immunostain at presentation, nonetheless, has shown protracted recurrence-free survival after 6 years of follow-up. So far, this is the first report for evaluating the mitotic activity in AGs using pHH3 immunostain.
authors: Department of Pathology and Lab. Medicine, North Shore-Long Island Jewish Health System, Hofstra North Shore-LIJ School of Medicine, 6 Ohio Drive, Suite 202, Lake Success, NY, 11042, USA. jli2@nshs.edu
authors: Jian Yi
authors: JY
authors: Li
authors: Lauren A
authors: LA
authors: Langford
authors: Adekunle
authors: A
authors: Adesina
authors: Surender R
authors: SR
authors: Bodhireddy
authors: Min
authors: M
authors: Wang
authors: Gregory N
authors: GN
authors: Fuller
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D005910:Glioma / Q000473:pathology*; D006657:Histones / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008940:Mitotic Index; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D006657:Histones