title: Gamete formation resets the aging clock in yeast.
abstract: Gametogenesis is a process whereby a germ cell differentiates into haploid gametes. We found that, in budding yeast, replicatively aged cells remove age-induced cellular damage during gametogenesis. Importantly, gametes of aged cells have the same replicative potential as those derived from young cells, indicating that life span resets during gametogenesis. Here, we explore the potential mechanisms responsible for gametogenesis-induced rejuvenation and discuss putative analogous mechanisms in higher eukaryotes.
authors: David H. Koch Institute for Integrative Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
authors: E
authors: E
authors: Ünal
authors: A
authors: A
authors: Amon
mesh_terms: D001683:Biological Clocks / Q000502:physiology*; D005854:Germ Cells / Q000254:growth & development*; D012441:Saccharomyces cerevisiae / Q000254:growth & development* / Q000502:physiology*; D013997:Time Factors