title: Role of Chlamydia trachomatis in miscarriage.
abstract: To determine the role of Chlamydia trachomatis in miscarriage, we prospectively collected serum, cervicovaginal swab specimens, and placental samples from 386 women with and without miscarriage. Prevalence of immunoglobulin G against C. trachomatis was higher in the miscarriage group than in the control group (15.2% vs. 7.3%; p = 0.018). Association between C. trachomatis-positive serologic results and miscarriage remained significant after adjustment for age, origin, education, and number of sex partners (odds ratio 2.3, 95% confidence interval 1.1-4.9). C. trachomatis DNA was more frequently amplified from products of conception or placenta from women who had a miscarriage (4%) than from controls (0.7%; p = 0.026). Immunohistochemical analysis confirmed C. trachomatis in placenta from 5 of 7 patients with positive PCR results, whereas results of immunohistochemical analysis were negative in placenta samples from all 8 negative controls tested. Associations between miscarriage and serologic/molecular evidence of C. trachomatis infection support its role in miscarriage.
authors: University Hospital of Lausanne, Lausanne, Switzerland.
authors: David
authors: D
authors: Baud
authors: Genevieve
authors: G
authors: Goy
authors: Katia
authors: K
authors: Jaton
authors: Maria-Chiara
authors: MC
authors: Osterheld
authors: Serafin
authors: S
authors: Blumer
authors: Nicole
authors: N
authors: Borel
authors: Yvan
authors: Y
authors: Vial
authors: Patrick
authors: P
authors: Hohlfeld
authors: Andreas
authors: A
authors: Pospischil
authors: Gilbert
authors: G
authors: Greub
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology / Q000276:immunology / Q000382:microbiology*; D000328:Adult; D002690:Chlamydia Infections / Q000150:complications*; D002692:Chlamydia trachomatis / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D004269:DNA, Bacterial / Q000032:analysis; D005260:Female; D006801:Humans; D015999:Multivariate Analysis; D010920:Placenta / Q000382:microbiology; D011247:Pregnancy; D011446:Prospective Studies; D012044:Regression Analysis
chemical_list: D004269:DNA, Bacterial