title: Barrett esophagus in long-term survivors of childhood solid tumors.
abstract: We report on 2 cases of long-term survivors of childhood solid tumors, who developed Barrett esophagus (BE) after treatment for neuroblastoma and Hodgkin lymphoma, respectively. Case 1: A stage 3 neuroblastoma was treated with surgery, carboplatin/etoposide chemotherapy, and supradiaphragmatic radiotherapy (30 Gy). Twelve years later, based on endoscopic and histologic findings, BE was diagnosed on the middle segment. Case 2: A stage IIIB Hodgkin lymphoma received mechloretamine, oncovin, procarbazine, prednisone/adriamycin, bleomycin, vinblastine, dacarbazine chemotherapy and supra/subdiaphragmatic radiotherapy (25 Gy). Nineteen years later, BE was diagnosed associated with an esophageal stricture. In long-term survivors of childhood tumors who had received chest/neck radiotherapy and chemotherapy, the risk of BE may be increased, therefore the diagnosis should be considered in the presence of gastroesophageal symptoms.
authors: Unit of Oncology, Department of Pediatrics, University of Rome Sapienza, Italy. amaliasc@tiscali.it
authors: Amalia
authors: A
authors: Schiavetti
authors: Giovanni
authors: G
authors: Di Nardo
authors: Annapaola
authors: A
authors: Ingrosso
authors: Damiano
authors: D
authors: Chiriacò
authors: Salvatore
authors: S
authors: Cucchiara
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D001471:Barrett Esophagus / Q000150:complications* / Q000628:therapy; D005260:Female; D006689:Hodgkin Disease / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D007223:Infant; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000175:diagnosis / Q000628:therapy*; D012307:Risk Factors; D017741:Survivors