title: Papaya epicarp extract protects against hydrogen peroxide-induced oxidative stress in human SH-SY5Y neuronal cells.
abstract: Recent studies indicated that regular consumption of antioxidant-rich foods reduces cellular oxidative stress and protects against health-related problems. This study aimed to assess the in vitro antioxidant properties of the papaya epicarp extract against hydrogen peroxide (H(2)O(2))-induced oxidative stress in human SH-SY5Y neuronal cells. Our study revealed that papaya epicarp extract acted as a potent free radical scavenger and provided neuroprotection against H(2)O(2)-induced oxidative stress. Papaya epicarp extract ameliorated glutathione depletion, restored total antioxidant capacity and augmented the inhibition of antioxidant enzymes (catalase, glutathione peroxidases and superoxide dismutase). In conclusion, papaya epicarp extract can be used as a functional dietary ingredient that might help in reducing the neurological health problems associated with various oxidative stress insults.
authors: Department of Food Science and Nutrition, College of Agricultural and Marine Sciences, Sultan Qaboos University, Muscat,  Sultanate of Oman.
authors: Nejib
authors: N
authors: Guizani
authors: Mostafa I
authors: MI
authors: Waly
authors: Amanat
authors: A
authors: Ali
authors: Ghalib
authors: G
authors: Al-Saidi
authors: Vendita
authors: V
authors: Singh
authors: Neeru
authors: N
authors: Bhatt
authors: Mohammad Shafiur
authors: MS
authors: Rahman
mesh_terms: D000975:Antioxidants / Q000494:pharmacology; D029441:Carica; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D016166:Free Radical Scavengers / Q000494:pharmacology; D005638:Fruit; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D009447:Neuroblastoma / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D018696:Neuroprotective Agents; D010936:Plant Extracts; D006861:Hydrogen Peroxide; D007770:L-Lactate Dehydrogenase