title: CA-125 level is associated with right ventricular echocardiographic parameters in patients with COPD.
abstract: OBJECTIVE
  A few studies have shown that elevated CA-125 levels are associated with chronic obstructive pulmonary disease (COPD). However, there are no data concerning the associaton between serum CA-125 levels and right ventricular (RV) function in COPD patients. This study aimed to evaluate the relationship between CA-125 level and RV echocardiographic parameters in COPD patients.
  
  
  METHODS
  Fifty-two patients with COPD (39 male/13 female, mean age 68.9 ± 5.7 years) were studied. The control group consisted of 30 age-sex matched healthy volunteers (23 male/7 female, mean age 64.2 ± 6.3 years). Patients were divided into two subgroups: patients without pulmonary hypertension (group I, n = 25) and with pulmonary hypertension (group II, n = 27). Conventional echocardiographic parameters, tissue Doppler imaging (TDI) and CA-125 level measurements were performed in all subjects.
  
  
  RESULTS
  Patients in group II had significantly higher CA-125 levels than those in group I and controls (P < 0.01). CA-125 levels in group I were also higher than control group (P < 0.05). CA-125 levels were correlated with left ventricle E/A ratio, systolic pulmonary artery pressure (sPAP), RV myocardial performance index, and RV fractional area change (r = 0.37, 0.56, 0.34, and -0.42, respectively, all with P < 0.05). There was an independent correlation between CA-125 levels and sPAP values (β = 0.76, P < 0.001).
  
  
  CONCLUSIONS
  Our results show an independent correlation between CA-125 levels and systolic pulmonary artery pressure in COPD patients. The clinical utility of these results at this point in time is unknown and deserves future research.
authors: Department of Cardiology, GATA HEH Training Hospital, Istanbul, Turkey. homeruz@gmail.com
authors: Omer
authors: O
authors: Uz
authors: Ejder
authors: E
authors: Kardesoglu
authors: Dilaver
authors: D
authors: Tas
authors: Gurkan
authors: G
authors: Acar
authors: Zafer
authors: Z
authors: Isilak
authors: Omer
authors: O
authors: Yiginer
authors: Mustafa
authors: M
authors: Aparci
authors: Bekir Yilmaz
authors: BY
authors: Cingozbay
authors: Bekir Sitki
authors: BS
authors: Cebeci
mesh_terms: D015415:Biomarkers / Q000097:blood; D018394:CA-125 Antigen / Q000097:blood*; D018618:Echocardiography, Doppler, Color / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D009200:Myocardial Contraction; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D011669:Pulmonary Wedge Pressure; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013318:Stroke Volume; D013599:Systole; D016278:Ventricular Function, Right / Q000502:physiology*
chemical_list: D015415:Biomarkers; D018394:CA-125 Antigen