title: An eye on RNAi in nematode parasites.
abstract: RNA interference (RNAi) has revolutionised approaches to gene function determination. From a parasitology perspective, gene function studies have the added dimension of providing validation data, increasingly deemed essential to the initial phases of drug target selection, pre-screen development. Notionally advantageous to those working on nematode parasites is the fact that Caenorhabditis elegans research spawned RNAi discovery and continues to seed our understanding of its fundamentals. Unfortunately, RNAi data for nematode parasites illustrate variable and inconsistent susceptibilities which undermine confidence and exploitation. Now well-ensconced in an era of nematode parasite genomics, we can begin to unscramble this variation.
authors: Molecular Bioscience-Parasitology, Institute of Agri-Food and Land Use, School of Biological Sciences, Queen's University Belfast, Belfast BT9 7BL, UK. a.maule@qub.ac.uk
authors: Aaron G
authors: AG
authors: Maule
authors: Paul
authors: P
authors: McVeigh
authors: Johnathan J
authors: JJ
authors: Dalzell
authors: Louise
authors: L
authors: Atkinson
authors: Angela
authors: A
authors: Mousley
authors: Nikki J
authors: NJ
authors: Marks
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics; D017238:Genes, Helminth / Q000235:genetics; D023281:Genomics; D006801:Humans; D009348:Nematoda / Q000235:genetics*; D010641:Phenotype; D010944:Plants / Q000469:parasitology; D034622:RNA Interference; D012330:RNA, Double-Stranded / Q000235:genetics; D018510:RNA, Helminth / Q000235:genetics / Q000378:metabolism; D015203:Reproducibility of Results
chemical_list: D012330:RNA, Double-Stranded; D018510:RNA, Helminth