title: Selective and specific I(f) inhibition with ivabradine: new perspectives for the treatment of cardiovascular disease.
abstract: Heart rate is a major determinant of myocardial oxygen demand and supply, and increased heart rate adversely affects the pathophysiology of myocardial ischemia. High resting heart rate is a risk factor in cardiovascular disease. The development of the heart rate-lowering agent ivabradine showed that heart rate was also an important treatment target, notably in coronary artery disease and heart failure. Indeed, heart rate reduction with ivabradine, a selective and specific I(f) inhibitor, reduces myocardial oxygen demand, increases diastolic perfusion time and improves energetics in ischemic myocardium. Ivabradine protects the myocardium during ischemia, improves left ventricular function in heart failure and reduces remodeling following myocardial infarction. It improves prognosis in patients with coronary artery disease, left ventricular dysfunction and heart rate ≥70 beats per minute, as well as in patients with heart failure and left ventricular dysfunction. Ivabradine is safe, well tolerated and can be used in combination with the main drugs for cardiovascular disease.
authors: Department of Cardiology, University of Ferrara, Salvatore Maugeri Foundation, IRCCS, Lumezzane, Italy. fri@unife.it
authors: Roberto
authors: R
authors: Ferrari
authors: Claudio
authors: C
authors: Ceconi
mesh_terms: D000818:Animals; D001552:Benzazepines / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002316:Cardiotonic Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D054815:Cyclic Nucleotide-Gated Cation Channels / Q000037:antagonists & inhibitors*; D003864:Depression, Chemical; D004347:Drug Interactions; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D000077550:Ivabradine; D009200:Myocardial Contraction / Q000187:drug effects; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D001552:Benzazepines; D002316:Cardiotonic Agents; D054815:Cyclic Nucleotide-Gated Cation Channels; D000077550:Ivabradine