title: Animal tumor models for PET in drug development.
abstract: Positron emission tomography (PET) is being increasingly applied to animal tumor models due to the need for proof-of-concept testing and preclinical efficacy studies of anticancer agents. Regardless of the nature of an experiment, investigators should carefully select a suitable animal tumor model as part of the experimental design. This review introduces sources of information and the guiding principles regarding applicability of various animal tumor models for PET in anticancer agent development especially for small animals.
authors: Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1-1 Naka, Itabashi, Tokyo 173-0022, Japan. toyohara@pet.tmig.or.jp
authors: Jun
authors: J
authors: Toyohara
authors: Kiichi
authors: K
authors: Ishiwata
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D055808:Drug Discovery / Q000379:methods*; D004703:Endocrine System / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D049268:Positron-Emission Tomography / Q000379:methods*; D011849:Radioactive Tracers
chemical_list: D011849:Radioactive Tracers