title: HIV Therapy Simulator: a graphical user interface for comparing the effectiveness of novel therapy regimens.
abstract: Computer simulation models can be useful in exploring the efficacy of HIV therapy regimens in preventing the evolution of drug-resistant viruses. Current modeling programs, however, were designed by researchers with expertise in computational biology, limiting their accessibility to those who might lack such a background. We have developed a user-friendly graphical program, HIV Therapy Simulator (HIVSIM), that is accessible to non-technical users. The program allows clinicians and researchers to explore the effectiveness of various therapeutic strategies, such as structured treatment interruptions, booster therapies and induction-maintenance therapies. We anticipate that HIVSIM will be useful for evaluating novel drug-based treatment concepts in clinical research, and as an educational tool.
  
  
  BACKGROUND
  HIV Therapy Simulator is freely available for Mac OS and Windows at http://sites.google.com/site/hivsimulator/.
  
  
  BACKGROUND
  jmittler@uw.edu.
  
  
  BACKGROUND
  Supplementary data are available at Bioinformatics online.
authors: Department of Microbiology, University of Washington, Seattle, WA 98195, USA.
authors: Huat Chye
authors: HC
authors: Lim
authors: Marcel E
authors: ME
authors: Curlin
authors: John E
authors: JE
authors: Mittler
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D003196:Computer Graphics; D003198:Computer Simulation; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D008954:Models, Biological; D019829:Nevirapine / Q000627:therapeutic use; D012984:Software; D014584:User-Computer Interface
chemical_list: D019380:Anti-HIV Agents; D019829:Nevirapine