title: Unilateral GPi-DBS as a treatment for levodopa-induced respiratory dyskinesia in Parkinson disease.
abstract: BACKGROUND
  Respiratory dyskinesia is a rare but disabling complication of levodopa therapy for Parkinson disease; however, its treatment has been limited to medication optimization.
  
  
  METHODS
  A 72-year-old woman with a 6-year history of Parkinson disease presented with severe and debilitating levodopa-induced respiratory dyskinesia, which manifested with a short and shallow breathing pattern and panting. These symptoms were observed coincident with limb and truncal dyskinesias. Both respiratory and limb/trunk dyskinesias were addressed by the implantation of a unilateral globus pallidus interna deep brain stimulator (GPi-DBS).
  
  
  CONCLUSIONS
  Although the mechanism of involvement of the respiratory system in dyskinesia is unknown, GPi-DBS seems to be a potentially viable treatment option for these patients.
authors: Department of Neurology, University of Florida Movement Disorders Center, Gainesville, FL 32610, USA.
authors: Genko
authors: G
authors: Oyama
authors: Kelly D
authors: KD
authors: Foote
authors: Sanjay S
authors: SS
authors: Iyer
authors: Pamela
authors: P
authors: Zeilman
authors: Nelson
authors: N
authors: Hwynn
authors: Charles E
authors: CE
authors: Jacobson
authors: Irene A
authors: IA
authors: Malaty
authors: Hubert H
authors: HH
authors: Fernandez
authors: Ramon L
authors: RL
authors: Rodriguez
authors: Michael S
authors: MS
authors: Okun
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents; D046690:Deep Brain Stimulation / Q000379:methods*; D004409:Dyskinesia, Drug-Induced / Q000150:complications / Q000628:therapy*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D005917:Globus Pallidus / Q000502:physiology*; D006801:Humans; D007980:Levodopa / Q000009:adverse effects; D010300:Parkinson Disease / Q000188:drug therapy; D012120:Respiration Disorders / Q000139:chemically induced / Q000628:therapy*
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa