title: Sphingolipids and cardiovascular diseases: lipoprotein metabolism, atherosclerosis and cardiomyopathy.
abstract: Heart disease is widely believed to develop from two pathological processes. Circulating lipoproteins containing the nondegradable lipid, cholesterol, accumulate within the arterial wall and perhaps are oxidized to more toxic lipids. Both lipid accumulation and vascular reaction to the lipids lead to the gradual thickening of the vascular wall. A second major process that in some circumstances is a primary event is the development of a local inflammatory reaction. This might be a reaction to vessel wall injury that accompanies infections, immune disease, and perhaps diabetes and renal failure. In this chapter, we will focus on the relationship between de novo synthesis of sphingolipids and lipid metabolism, atherosclerosis, and cardiomyopathy.
authors: Department of Cell Biology, Downstate Medical Center, State University of New York, Brooklyn, New York, USA. xian-cheng.jiang@downstate.edu
authors: Xian-Cheng
authors: XC
authors: Jiang
authors: Ira J
authors: IJ
authors: Goldberg
authors: Tae-Sik
authors: TS
authors: Park
mesh_terms: D000818:Animals; D017209:Apoptosis; D050197:Atherosclerosis / Q000378:metabolism*; D009202:Cardiomyopathies / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000378:metabolism* / Q000473:pathology; D002784:Cholesterol / Q000378:metabolism; D003327:Coronary Disease / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology; D005227:Fatty Acids / Q000378:metabolism; D005229:Fatty Acids, Monounsaturated / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation; D008074:Lipoproteins / Q000378:metabolism*; D020935:MAP Kinase Signaling System; D008955:Models, Cardiovascular; D051102:Serine C-Palmitoyltransferase / Q000037:antagonists & inhibitors / Q000378:metabolism; D013107:Sphingolipids / Q000378:metabolism*; D017855:Transferases (Other Substituted Phosphate Groups) / Q000378:metabolism
chemical_list: D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D008074:Lipoproteins; D013107:Sphingolipids; D002784:Cholesterol; D051102:Serine C-Palmitoyltransferase; D017855:Transferases (Other Substituted Phosphate Groups); C070186:phosphatidylcholine-ceramide phosphocholine transferase; C001996:thermozymocidin