title: Clinicopathological Role of Serum-Derived Hyaluronan-Associated Protein (SHAP)-Hyaluronan Complex in Endometrial Cancer.
abstract: The role of hyaluronan (HA), serum-derived HA-associated protein (SHAP)-HA complex and hyaluronan synthase (HAS) in endometrial carcinomas was investigated. The relationship of metalloproteinase (MMP) and its inhibitor (TIMP) with HA and the SHAP-HA complex was also examined. The expression of HAS1 was related to the depth of myometrial invasion and lymph-vascular space involvement. The serum levels of HA, SHAP-HA complex, MMP-9, and TIMP-1 were increased in related with the depth of myometrial invasion, histological grade and lymph-vascular space involvement. They were also higher in the HAS1-positive group compared to -negative group. The serum concentrations of HA and SHAP-HA complex had a significant correlation with the MMP-9 and TIMP-1. The patients with elevated SHAP-HA complex had the shorter disease-free survival. The multivariate analysis revealed that the SHAP-HA complex was the independent variable for disease-free survival of endometrial cancer patients. In conclusion, the elevation of serum SHAP-HA complex depended on the HAS1 expression and the SHAP-HA complex is a useful marker to predict disease recurrence in endometrial cancer patients. The SHAP-HA complex may promote the lymph-vascular space involvement and the synthesis and activation of MMP-9 and TIMP-1 in the progression of endometrial cancer.
authors: Department of Obstetrics and Gynecology, School of Medicine, Aichi Medical University, Nagakute-cho, Aichi 480-1195, Japan.
authors: Hiromitsu
authors: H
authors: Yabushita
authors: Keita
authors: K
authors: Iwasaki
authors: Kouhei
authors: K
authors: Kanyama
authors: Yukihiko
authors: Y
authors: Obayashi
authors: Lisheng
authors: L
authors: Zhuo
authors: Naoki
authors: N
authors: Itano
authors: Koji
authors: K
authors: Kimata
authors: Akihiko
authors: A
authors: Wakatsuki