title: Comparison of peripheral neuropathy induced by standard and nanoparticle albumin-bound paclitaxel in rats.
abstract: Nanoparticle albumin-bound paclitaxel (nab-paclitaxel) is delivered to tumors and increases antitumor activity compared with solvent-based paclitaxel. However, in a clinical trial, higher and lower rates of peripheral neuropathy and neutropenia were observed. In this study, we compared the effects of nab-paclitaxel and standard paclitaxel on pain behaviors in rats. Repeated administration of nab-paclitaxel dose-dependently induced both mechanical and cold allodynia, and the effects of nab-paclitaxel on pain behaviors tended to be stronger than that of standard paclitaxel at the doses used clinically. These results suggest that closer attention must be paid to the neuropathy when administering nab-paclitaxel in clinical settings.
authors: Department of Pharmacy, Kyushu University Hospital, Higashi-ku, Fukuoka 812-8582, Japan.
authors: Yuji
authors: Y
authors: Yamashita
authors: Nobuaki
authors: N
authors: Egashira
authors: Ken
authors: K
authors: Masuguchi
authors: Soichiro
authors: S
authors: Ushio
authors: Takehiro
authors: T
authors: Kawashiri
authors: Ryozo
authors: R
authors: Oishi
mesh_terms: D000418:Albumins / Q000009:adverse effects*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects*; D003080:Cold Temperature; D004305:Dose-Response Relationship, Drug; D018737:Hand Strength; D006930:Hyperalgesia / Q000139:chemically induced*; D008297:Male; D009048:Motor Skills / Q000187:drug effects; D053758:Nanoparticles / Q000009:adverse effects*; D017239:Paclitaxel / Q000009:adverse effects*; D010146:Pain / Q000139:chemically induced*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: C520255:130-nm albumin-bound paclitaxel; D000418:Albumins; D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel