title: [Somatostatin in breast cancer].
abstract: In man, somatostatin is a hormone mostly produced by hypothalamus. It plays different parts in hormonal regulation through many specific receptors in human body. It has also two interesting actions such as an anti-secretory activity, mostly on the gastrointestinal system and an antiproliferative action on tumor cells. Many synthetic somatostatin analogues, more stable than the natural one, have been developed and are already used in digestive surgery to treat postoperative digestive fistula. Also, the development of specific polyclonal antibodies allowed the identification of five specific somatostatin receptors and their localization in different cell species. The presence of the five receptors in breast cancer cells has than been demonstrated. The purpose of this literature review is to clarify the potential antitumor effect of somatastatin analogues in breast cancer; its use as a preventive agent on lymphorrhea after breast surgery and its employment in imaging for early breast cancer detection.
authors: Service de gynécologie obstétrique, Hôpital Tenon, APHP, Paris, France.
authors: Albane
authors: A
authors: Frati
authors: Martine
authors: M
authors: Antoine
authors: Anita
authors: A
authors: Rodenas
authors: Joseph
authors: J
authors: Gligorov
authors: Roman
authors: R
authors: Rouzier
authors: Elisabeth
authors: E
authors: Chéreau
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D008197:Lymph Node Excision / Q000009:adverse effects; D008209:Lymphedema / Q000209:etiology / Q000517:prevention & control*; D008408:Mastectomy / Q000009:adverse effects; D013004:Somatostatin / Q000031:analogs & derivatives*; D016896:Treatment Outcome
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013004:Somatostatin