title: Synthesis of methylenebis(phosphonate) analogues of 2-, 4-, and 6-pyridones of nicotinamide adenine dinucleotide.
abstract: The synthesis of metabolically stable methylenebis(phosphonate) analogues of 2-, 4-, and 6-pyridones of nicotinamide adenine dinucleotide (NAD) is reported. In contrast to natural pyrophosphates, these NAD analogues are able to penetrate the cell membrane and can be used as probes in cellular assays.
authors: Center for Drug Design, University of Minnesota, Minneapolis, Minnesota 55455, USA.
authors: Krzysztof
authors: K
authors: Felczak
authors: Krzysztof W
authors: KW
authors: Pankiewicz
mesh_terms: D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D004164:Diphosphonates / Q000138:chemical synthesis* / Q000737:chemistry; D009243:NAD / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D011728:Pyridones / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D004164:Diphosphonates; D011728:Pyridones; D009243:NAD; C027474:methylene diphosphonate