title: Exogenous oxytocin reverses the decrease of colonic smooth muscle contraction in antenatal maternal hypoxia mice via ganglia.
abstract: Oxytocin (OT) has been reported to have a potential protective effect on stress-induced functional gastrointestinal disorders. This study determined whether colonic contraction in adults was affected by antenatal maternal hypoxia, and whether OT is involved in antenatal maternal hypoxia induced colonic contraction disorder. Isometric spontaneous contractions were recorded in colonic longitudinal muscle strips in order to investigate colonic contractions and the effects of exogenous OT on the contraction in antenatal maternal hypoxia and control mice. Both high potassium and carbachol-induced contractions of proximal colon but not distal colon were reduced in antenatal maternal hypoxia mice. Exogenous OT decreased the contractions of proximal colonic smooth muscle strips in control mice, while it increased contractions in antenatal maternal hypoxia mice. OT increased the contractions of distal colonic smooth muscle strips in both antenatal maternal hypoxia and control mice. Hexamethonium blocked the OT-induced potentiation of proximal colon but not distal colon in antenatal maternal hypoxia mice. These results suggest that exogenous oxytocin reverses the decrease of proximal colonic smooth muscle contraction in antenatal maternal hypoxia mice via ganglia.
authors: Department of Physiology, Tongji University School of Medicine, Shanghai, 200092, PR China. xiedping@tongji.edu.cn
authors: Dong-Ping
authors: DP
authors: Xie
authors: Xiao
authors: X
authors: Yang
authors: Chun-Yan
authors: CY
authors: Cao
authors: Hai-Hong
authors: HH
authors: Wang
authors: Yu-Xian
authors: YX
authors: Li
authors: Ying
authors: Y
authors: Qin
authors: Jie-Ping
authors: JP
authors: Zhang
authors: Xin-Wen
authors: XW
authors: Chang
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D003106:Colon / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology*; D005260:Female; D005724:Ganglia / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D005769:Gastrointestinal Motility / Q000187:drug effects / Q000502:physiology; D000860:Hypoxia / Q000503:physiopathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000166:cytology / Q000187:drug effects*; D010121:Oxytocin / Q000494:pharmacology*; D011247:Pregnancy
chemical_list: D010121:Oxytocin