title: Effect of pamamycin-607 on secondary metabolite production by Streptomyces spp.
abstract: The effect of the aerial mycelium-inducing compound, pamamycin-607, on antibiotic production by several Streptomyces spp. was examined. Exposure to 6.6 µM pamamycin-607 stimulated by 2.7 fold the puromycin production by Streptomyces alboniger NBRC 12738, in which pamamycin-607 had first been isolated, and restored aerial mycelium formation. Pamamycin-607 also stimulated the respective production of streptomycin by S. griseus NBRC 12875 and that of cinerubins A and B by S. tauricus JCM 4837 by approximately 1.5, 1.7 and 1.9 fold. The antibiotic produced by Streptomyces sp. 91-a was identified as virginiamycin M(1), and its synthesis was enhanced 2.6 fold by pamamycin-607. These results demonstrate that pamamycin-607 not only restored or stimulated aerial mycelium formation, but also stimulated secondary metabolite production.
authors: Department of Plant Production, United Graduate School of Agricultural Sciences, Tokyo University of Agriculture and Technology.
authors: Makoto
authors: M
authors: Hashimoto
authors: Hirotaka
authors: H
authors: Katsura
authors: Risako
authors: R
authors: Kato
authors: Hiroshi
authors: H
authors: Kawaide
authors: Masahiro
authors: M
authors: Natsume
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid; D018942:Macrolides / Q000494:pharmacology*; D025282:Mycelium / Q000187:drug effects / Q000502:physiology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013302:Streptomyces / Q000187:drug effects / Q000502:physiology; D013307:Streptomycin / Q000096:biosynthesis* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; C470905:pamamycin-607; D013307:Streptomycin