title: Estimation of aneurysm wall stresses created by treatment with a shape memory polymer foam device.
abstract: In this study, compliant latex thin-walled aneurysm models are fabricated to investigate the effects of expansion of shape memory polymer foam. A simplified cylindrical model is selected for the in-vitro aneurysm, which is a simplification of a real, saccular aneurysm. The studies are performed by crimping shape memory polymer foams, originally 6 and 8 mm in diameter, and monitoring the resulting deformation when deployed into 4-mm-diameter thin-walled latex tubes. The deformations of the latex tubes are used as inputs to physical, analytical, and computational models to estimate the circumferential stresses. Using the results of the stress analysis in the latex aneurysm model, a computational model of the human aneurysm is developed by changing the geometry and material properties. The model is then used to predict the stresses that would develop in a human aneurysm. The experimental, simulation, and analytical results suggest that shape memory polymer foams have potential of being a safe treatment for intracranial saccular aneurysms. In particular, this work suggests oversized shape memory foams may be used to better fill the entire aneurysm cavity while generating stresses below the aneurysm wall breaking stresses.
authors: Department of Biomedical Engineering, Texas A&M University, MS 3120, 5045 Emerging Technologies Building, College Station, TX 77843-3120, USA.
authors: Wonjun
authors: W
authors: Hwang
authors: Brent L
authors: BL
authors: Volk
authors: Farida
authors: F
authors: Akberali
authors: Pooja
authors: P
authors: Singhal
authors: John C
authors: JC
authors: Criscione
authors: Duncan J
authors: DJ
authors: Maitland
mesh_terms: D000783:Aneurysm / Q000503:physiopathology*; D006801:Humans; D007840:Latex; D008962:Models, Theoretical; D011108:Polymers; D013312:Stress, Physiological
chemical_list: D007840:Latex; D011108:Polymers