title: The decrease of serum MMP-2 activity corresponds to alcoholic cirrhosis stage.
abstract: Because of numerous limitations for liver biopsy, a noninvasive marker of liver cirrhosis is sought. Promising indicators seem to be matrix metalloproteinases (MMPs) that are responsible for degradation of extracellular matrix. The aim of the study was to evaluate the gelatinase activities (MMP-2 and MMP-9) in patients with different stages of alcoholic cirrhosis. Sixty-seven outpatients who presented various stages of alcoholic cirrhosis according to Child-Turcotte-Pugh criteria and 26 healthy control subjects were enrolled. Blood samples were collected for MMP-2 and MMP-9 activities. A significant decrease of serum MMP-2 activity was noted in stages B and C of cirrhosis in comparison with control. Serum MMP-9 activity did not depend on the stage of cirrhosis. The MMP-2 levels, but not those of MMP-9, may be of value in understanding the pathogenesis and progression of alcoholic cirrhosis.
authors: Department of Gastroenterology with Endoscopic Unit, Medical University of Lublin, Lublin, Poland. agnieszka.madro@wp.pl
authors: Agnieszka
authors: A
authors: Madro
authors: Grazyna
authors: G
authors: Czechowska
authors: Maria
authors: M
authors: Slomka
authors: Krzysztof
authors: K
authors: Celinski
authors: Stanislawa
authors: S
authors: Szymonik-Lesiuk
authors: Jacek
authors: J
authors: Kurzepa
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D018450:Disease Progression; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood* / Q000201:enzymology; D020778:Matrix Metalloproteinase 2 / Q000097:blood*; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9