title: Pretransplant serum ferritin has a prognostic influence on allogeneic transplant regardless of disease risk.
abstract: A multicenter retrospective analysis of the influence of pretransplant serum ferritin (SF) was performed in 261 adult recipients of allogeneic hematopoietic stem cell transplant (allo-HSCT), including 159 patients with acute myeloid leukemia (AML), 66 with acute lymphoid leukemia (ALL) and 36 with myelodysplastic syndrome (MDS). Patients were divided into subgroups according to the pretransplant SF level [< 1000 ng/mL (low) vs. ≥ 1000 ng/mL (high)] and disease status at transplant. A high SF level was significantly associated with high disease risk (p = 0.041), but pretransplant SF and disease risk were independent significant prognostic factors for overall survival (OS), disease-free survival (DFS) and non-relapse mortality rate (NRM) on multivariate analysis. The high-SF group showed a worse outcome than the low-SF group among both standard-risk patients (OS: 54% vs. 64%, p = 0.043; DFS: 46% vs. 57%, p = 0.031) and high-risk patients (OS: 16% vs. 35%, p = 0.001; DFS: 15% vs. 34%, p = 0.001). In conclusion, a high SF at transplant adversely influences the outcome of allo-HSCT regardless of disease risk in patients with acute leukemia and MDS.
authors: Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan. tcbnt@yokohama-cu.ac.jp
authors: Takayoshi
authors: T
authors: Tachibana
authors: Masatsugu
authors: M
authors: Tanaka
authors: Ayumi
authors: A
authors: Numata
authors: Hirotaka
authors: H
authors: Takasaki
authors: Satomi
authors: S
authors: Ito
authors: Rika
authors: R
authors: Ohshima
authors: Maki
authors: M
authors: Hagihara
authors: Etsuko
authors: E
authors: Yamazaki
authors: Naoto
authors: N
authors: Tomita
authors: Katsumichi
authors: K
authors: Fujimaki
authors: Jun
authors: J
authors: Taguchi
authors: Rika
authors: R
authors: Sakai
authors: Hiroyuki
authors: H
authors: Fujita
authors: Shin
authors: S
authors: Fujisawa
authors: Atsuo
authors: A
authors: Maruta
authors: Yoshiaki
authors: Y
authors: Ishigatsubo
authors: Heiwa
authors: H
authors: Kanamori
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D015415:Biomarkers; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D007938:Leukemia / Q000097:blood* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000097:blood* / Q000601:surgery; D009363:Neoplasm Proteins / Q000097:blood*; D011300:Preoperative Care; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D033581:Stem Cell Transplantation; D019172:Transplantation Conditioning / Q000379:methods; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015415:Biomarkers; D009363:Neoplasm Proteins; D005293:Ferritins