title: Short report: A calcified Taenia solium granuloma associated with recurrent perilesional edema causing refractory seizures: histopathological features.
abstract: We describe the first detailed histological description of an excised calcified Taenia solium granuloma from a patient who developed recurrent seizures associated with perilesional edema surrounding a calcified cysticercus (PEC). The capsule, around a degenerated cysticercus, contained marked mononuclear infiltrates that extended to adjacent brain, which showed marked astrocytosis, microgliosis, and inflammatory perivascular infiltrates. The presence of large numbers of mononuclear cells supports an inflammatory cause of PEC. Immunosuppression or anti-inflammatory measures may be able to treat and prevent PEC and recurrent seizures.
authors: Department of Infectious Diseases, Lahey Clinic, Burlington, Massachusetts, USA.
authors: Winnie W
authors: WW
authors: Ooi
authors: Subhashie
authors: S
authors: Wijemanne
authors: Christine B
authors: CB
authors: Thomas
authors: Martha
authors: M
authors: Quezado
authors: Charles R
authors: CR
authors: Brown
authors: Theodore E
authors: TE
authors: Nash
mesh_terms: D015766:Albendazole / Q000627:therapeutic use; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use; D000927:Anticonvulsants / Q000627:therapeutic use; D002114:Calcinosis / Q000150:complications / Q000469:parasitology* / Q000473:pathology; D004487:Edema / Q000209:etiology* / Q000473:pathology; D006099:Granuloma / Q000150:complications / Q000469:parasitology* / Q000473:pathology; D006801:Humans; D000077287:Levetiracetam; D008297:Male; D020019:Neurocysticercosis / Q000150:complications / Q000469:parasitology* / Q000473:pathology; D010889:Piracetam / Q000031:analogs & derivatives / Q000627:therapeutic use; D012640:Seizures / Q000188:drug therapy / Q000209:etiology*; D041201:Taenia solium; D014635:Valproic Acid / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000871:Anthelmintics; D000927:Anticonvulsants; D000077287:Levetiracetam; D014635:Valproic Acid; D015766:Albendazole; D010889:Piracetam