title: Polymeric systems containing dual biologically active ions.
abstract: This paper reports the synthesis and characterization of dual functional polymerizable salts containing quaternary ammonium cations ionically linked to non steroidal anti-inflammatory drugs (NSAIDs), and their polymers and copolymeric systems obtained with acrylic monomers of different hydrophilicity, e.g. methyl methacrylate and 2-hydroxyethyl methacrylate. NSAIDs used were meclofenamic acid, ketoprofen and ibuprofen. Sustained release of the NSAID from polymeric and copolymeric samples was observed over a period of 10 days and the hydrophobic/hydrophilic character of both the polymeric system and the drug played a role in the release behaviour. The antimicrobial activity of dual functional monomeric and polymeric derivatives was confirmed against Gram-positive and Gram-negative bacteria and polymeric compounds presented higher bactericidal action than the precursory monomers. The extracts of copolymeric samples had anti-inflammatory activity in a nitric oxide inhibitory assay on RAW 264.7 cells and they produced a NO inhibition around 80% within the first seven days.
authors: Institute of Polymer Science and Technology, CSIC, C/Juan de la Cierva 3, 28006 Madrid, Spain.
authors: Francisco
authors: F
authors: Parra-Ruiz
authors: Estefanía
authors: E
authors: Toledano
authors: Mar
authors: M
authors: Fernández-Gutiérrez
authors: Nina
authors: N
authors: Dinjaski
authors: María Auxiliadora
authors: MA
authors: Prieto
authors: Blanca
authors: B
authors: Vázquez-Lasa
authors: Julio
authors: J
authors: San Román
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D002460:Cell Line; D003692:Delayed-Action Preparations / Q000737:chemistry*; D008689:Methacrylates / Q000737:chemistry*; D020366:Methylmethacrylate / Q000737:chemistry*; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D008689:Methacrylates; D000644:Quaternary Ammonium Compounds; D020366:Methylmethacrylate; D009569:Nitric Oxide; C005044:hydroxyethyl methacrylate