title: Enhanced guided bone regeneration by asymmetrically porous PCL/pluronic F127 membrane and ultrasound stimulation.
abstract: Recently, we developed a novel method for fabricating a guided bone regeneration (GBR) membrane with an asymmetrical pore structure and hydrophilicity by an immersion precipitation method. Results from an animal study, in a cranial defect model in rats, indicated that the unique asymmetrically porous GBR membrane would provide a good environment for bone regeneration. In the present study, we applied low intensity pulsed ultrasound as a simple and non-invasive stimulus to an asymmetrically porous polycaprolactone (PCL)/Pluronic F127 GBR membrane-implanted site transcutaneously in rats to investigate the feasibility of using ultrasound to stimulate enhanced bone regeneration through the membrane. It was observed that the ultrasound-stimulated PCL/F127 GBR membrane group had much faster bone regeneration behavior than a PCL/F127 membrane group w/o ultrasound or a control group (w/o membrane and ultrasound). The greater bone regeneration behavior in the GBR membrane/ultrasound group may be caused by a synergistic effect of the asymmetrically porous PCL/F127 membrane with unique properties (selective permeability, hydrophilicity and osteoconductivity), and the stimulatory effect of ultrasound (induction of angiogenesis and osteogenesis of cells).
authors: a Department of Advanced Materials , Hannam University , 461-6 Jeonmin Dong , Yuseong Gu , Daejeon , 305-811 , South Korea.
authors: Se Heang
authors: SH
authors: Oh
authors: Tae Ho
authors: TH
authors: Kim
authors: So Young
authors: SY
authors: Chun
authors: Eui Kyun
authors: EK
authors: Park
authors: Jin Ho
authors: JH
authors: Lee
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000737:chemistry; D002113:Calcification, Physiologic; D004195:Disease Models, Animal; D005240:Feasibility Studies; D048091:Guided Tissue Regeneration / Q000295:instrumentation / Q000379:methods*; D008422:Materials Testing; D008567:Membranes, Artificial; D020442:Poloxamer / Q000737:chemistry; D011091:Polyesters / Q000737:chemistry; D016062:Porosity; D017207:Rats, Sprague-Dawley; D012886:Skull / Q000000981:diagnostic imaging / Q000293:injuries / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome; D014464:Ultrasonic Therapy / Q000379:methods*; D014463:Ultrasonography
chemical_list: D018786:Bone Substitutes; D008567:Membranes, Artificial; D011091:Polyesters; D020442:Poloxamer; C016240:polycaprolactone