title: Direct functionalization of (un)protected tetrahydroisoquinoline and isochroman under iron and copper catalysis: two metals, two mechanisms.
abstract: A highly facile, straightforward synthesis of 1-(3-indolyl)-tetrahydroisoquinolines was developed using either simple copper or iron catalysts. N-protected and unprotected tetrahydroisoquinolines (THIQ) could be used as starting materials. Extension of the substrate scope of the pronucleophile from indoles to pyrroles and electron-rich arenes was realized. Additionally, methoxyphenylation is not limited to THIQ but can be carried out on isochroman as well, again employing iron and copper catalysis.
authors: Institute of Applied Synthetic Chemistry, Vienna University of Technology, 1060 Vienna, Austria.
authors: Michael
authors: M
authors: Ghobrial
authors: Michael
authors: M
authors: Schnürch
authors: Marko D
authors: MD
authors: Mihovilovic
mesh_terms: D002384:Catalysis; D002839:Chromans / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D008024:Ligands; D008670:Metals / Q000737:chemistry; D015394:Molecular Structure; D044005:Tetrahydroisoquinolines / Q000737:chemistry*
chemical_list: D002839:Chromans; D008024:Ligands; D008670:Metals; D044005:Tetrahydroisoquinolines; D003300:Copper; D007501:Iron