title: Epstein-Barr virus-associated smooth muscle tumor of the tonsil.
abstract: Smooth muscle tumors of the tonsil are rare. Recently, the occurrence of Epstein-Barr virus-associated smooth muscle tumor (EBV-SMT) has been increasingly recognized in immunocompromised patients, mainly post-transplantation and AIDS patients. The clinicopathologic features of EBV-SMT are different from conventional smooth muscle tumors. To the best of our knowledge, EBV-SMT involving the tonsil in an AIDS patient has not been reported. A 27-year-old man presented with a 2.2cm right tonsillar mass six months after AIDS diagnosis. The tumor was composed of a cellular proliferation of oval to spindle-shaped cells with mitotic count up to 10 in 10 high-power fields. The diagnosis of EBV-SMT was confirmed by in situ hybridization for EBV-encoded RNA (EBER) transcripts. Synchronous lesions were also detected in the liver and peritoneum by an abdominal computed tomographic scan. EBV-SMT should be included in the differential diagnoses of a mesenchymal tumor in immunocompromised patients, and in the differential diagnoses of a smooth muscle tumor occurring in uncommon sites including the tonsil.
authors: Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
authors: Songkiet
authors: S
authors: Suwansirikul
authors: Kornkanok
authors: K
authors: Sukpan
authors: Pichit
authors: P
authors: Sittitrai
authors: Supaporn
authors: S
authors: Suwiwat
authors: Surapan
authors: S
authors: Khunamornpong
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000328:Adult; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000276:immunology; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D018235:Smooth Muscle Tumor / Q000473:pathology / Q000821:virology*; D014067:Tonsillar Neoplasms / Q000473:pathology / Q000821:virology*