title: Neurological manifestations of coinfection with HIV and human T-lymphotropic virus type 1.
abstract: HIV-individuals are at risk for human T-lymphotropic virus (HTLV) coinfection and neurological diseases. Little is known about the impact of HAART among coinfected patients. In this study, 47 out of 428 HIV individuals were coinfected with HTLV (10.9%). Coinfection was an independent variable associated with neurological outcome (odds ratio 8.73). Coinfection was associated with myelopathy [chi square (X(2)) = 93, P < 0.001], peripheral neuropathy (X(2) = 6.5, P = 0.01), and hepatitis C virus infection (X(2) = 36.5, P < 0.001). HAART did not appear to protect against neurological diseases and had no impact on HTLV proviral load.
authors: Laboratório de Pesquisa Clínica em Neuroinfecção, Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil. marcustulius@ipec.fiocruz.br
authors: Marcus T T
authors: MT
authors: Silva
authors: Elizabeth S
authors: ES
authors: Neves
authors: Beatriz
authors: B
authors: Grinsztejn
authors: Otávio
authors: O
authors: de Melo Espíndola
authors: Doris
authors: D
authors: Schor
authors: Abelardo
authors: A
authors: Araújo
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D060085:Coinfection; D015480:Deltaretrovirus Antibodies / Q000097:blood*; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000503:physiopathology*; D015491:HTLV-II Infections / Q000150:complications / Q000503:physiopathology*; D018937:Hepatitis C Antibodies / Q000097:blood; D015368:Human T-lymphotropic virus 1 / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010523:Peripheral Nervous System Diseases / Q000503:physiopathology / Q000821:virology*; D013118:Spinal Cord Diseases / Q000821:virology; D019562:Viral Load
chemical_list: D015480:Deltaretrovirus Antibodies; D018937:Hepatitis C Antibodies