title: Transcranial direct current stimulation in refractory continuous spikes and waves during slow sleep: a controlled study.
abstract: Cathodal transcranial direct current stimulation (tDCS) decreases cortical excitability. The purpose of the study was to investigate whether cathodal tDCS could interrupt the continuous epileptiform activity. Five patients with focal, refractory continuous spikes and waves during slow sleep were recruited. Cathodal tDCS and sham stimulation were applied to the epileptic focus, before sleep (1 mA; 20 min). Cathodal tDCS did not reduce the spike-index in any of the patients.
authors: Department of Neurophysiology, Danish Epilepsy Centre, Dianalund, Denmark.
authors: Edina T
authors: ET
authors: Varga
authors: Daniella
authors: D
authors: Terney
authors: Mary D
authors: MD
authors: Atkins
authors: Marina
authors: M
authors: Nikanorova
authors: Ditte S
authors: DS
authors: Jeppesen
authors: Peter
authors: P
authors: Uldall
authors: Helle
authors: H
authors: Hjalgrim
authors: Sándor
authors: S
authors: Beniczky
mesh_terms: D002540:Cerebral Cortex / Q000503:physiopathology; D002648:Child; D018592:Cross-Over Studies; D004569:Electroencephalography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012890:Sleep / Q000502:physiology*; D013226:Status Epilepticus / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy*; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D017211:Treatment Failure