title: Correlation mapping method for generating microcirculation morphology from optical coherence tomography (OCT) intensity images.
abstract: Standard optical coherence tomography (OCT) in combination with software tools can be harnessed to generate vascular maps in vivo. In this study we have successfully combined a software algorithm based on correlation statistic to reveal microcirculation morphology on OCT intensity images of a mouse brain in vivo captured trans-cranially and through a cranial window. We were able to estimate vessel geometry at bifurcation as well as along vessel segments down-to mean diameters of about 24 μm. Our technique has potential applications in cardiovascular-related parameter measurements such as volumetric flow as well as in assessing vascular density of normal and diseased tissue.
authors: University of Limerick, Department of Physics, Castletroy, Limerick, Ireland. enock.jonathan@ul.ie
authors: Enock
authors: E
authors: Jonathan
authors: Joey
authors: J
authors: Enfield
authors: Martin J
authors: MJ
authors: Leahy
mesh_terms: D000465:Algorithms; D000818:Animals; D001921:Brain / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology*; D002319:Cardiovascular System / Q000378:metabolism / Q000473:pathology; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D051379:Mice; D008833:Microcirculation; D012680:Sensitivity and Specificity; D012984:Software; D041623:Tomography, Optical Coherence / Q000379:methods*