title: MCP-1 and CCR2 gene variants in oral squamous cell carcinoma.
abstract: OBJECTIVE
  We aimed to investigate a possible association of the MCP-1 and CCR2 polymorphisms with the risk of developing oral squamous cell carcinoma (OSCC).
  
  
  METHODS
  MCP-1 A2518G and CCR2 V64I gene polymorphisms were performed by polymerase chain reaction and restriction fragment length polymorphism, in 129 patients with OSCC and 140 healthy control subjects.
  
  
  RESULTS
  Individuals who had G allele and GG genotype of MCP-1, and 64I allele and wt/64I genotype of CCR2 had increased risk for OSCC (P<0.05.) In contrast, individuals with CCR2 wt/wt genotype seem to be protected from OSCC (P < 0.01). Haplotype analysis revealed that MCP-1G: CCR2 64I haplotype frequencies were significantly higher in patients than those of controls (P = 0.001).
  
  
  CONCLUSIONS
  We can suggest that the G allele of MCP-1 and 64I allele of CCR2 may be risk factors for OSCC.
authors: Faculty of Dentistry, Department of Oral Surgery and Medicine, Istanbul University, Turkey.
authors: K
authors: K
authors: Bektas-Kayhan
authors: M
authors: M
authors: Unur
authors: Z
authors: Z
authors: Boy-Metin
authors: B
authors: B
authors: Cakmakoglu
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000235:genetics*; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic; D054390:Receptors, CCR2 / Q000235:genetics*; D012307:Risk Factors; D012907:Smoking
chemical_list: C515334:CCR2 protein, human; D018932:Chemokine CCL2; D054390:Receptors, CCR2