title: Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria.
abstract: Natural killer T cells (NKT cells) recognize glycolipid antigens presented by CD1d. These cells express an evolutionarily conserved, invariant T cell antigen receptor (TCR), but the forces that drive TCR conservation have remained uncertain. Here we show that NKT cells recognized diacylglycerol-containing glycolipids from Streptococcus pneumoniae, the leading cause of community-acquired pneumonia, and group B Streptococcus, which causes neonatal sepsis and meningitis. Furthermore, CD1d-dependent responses by NKT cells were required for activation and host protection. The glycolipid response was dependent on vaccenic acid, which is present in low concentrations in mammalian cells. Our results show how microbial lipids position the sugar for recognition by the invariant TCR and, most notably, extend the range of microbes recognized by this conserved TCR to several clinically important bacteria.
authors: Division of Developmental Immunology, La Jolla Institute for Allergy & Immunology, La Jolla, California, USA.
authors: Yuki
authors: Y
authors: Kinjo
authors: Petr
authors: P
authors: Illarionov
authors: José Luis
authors: JL
authors: Vela
authors: Bo
authors: B
authors: Pei
authors: Enrico
authors: E
authors: Girardi
authors: Xiangming
authors: X
authors: Li
authors: Yali
authors: Y
authors: Li
authors: Masakazu
authors: M
authors: Imamura
authors: Yukihiro
authors: Y
authors: Kaneko
authors: Akiko
authors: A
authors: Okawara
authors: Yoshitsugu
authors: Y
authors: Miyazaki
authors: Anaximandro
authors: A
authors: Gómez-Velasco
authors: Paul
authors: P
authors: Rogers
authors: Samira
authors: S
authors: Dahesh
authors: Satoshi
authors: S
authors: Uchiyama
authors: Archana
authors: A
authors: Khurana
authors: Kazuyoshi
authors: K
authors: Kawahara
authors: Hasan
authors: H
authors: Yesilkaya
authors: Peter W
authors: PW
authors: Andrew
authors: Chi-Huey
authors: CH
authors: Wong
authors: Kazuyoshi
authors: K
authors: Kawakami
authors: Victor
authors: V
authors: Nizet
authors: Gurdyal S
authors: GS
authors: Besra
authors: Moriya
authors: M
authors: Tsuji
authors: Dirk M
authors: DM
authors: Zajonc
authors: Mitchell
authors: M
authors: Kronenberg
mesh_terms: D000818:Animals; D055610:Antigens, CD1d / Q000737:chemistry / Q000502:physiology; D002460:Cell Line; D006017:Glycolipids / Q000737:chemistry / Q000276:immunology*; D006094:Gram-Positive Bacteria / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D051379:Mice; D008810:Mice, Inbred C57BL; D055611:Natural Killer T-Cells / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism
chemical_list: D055610:Antigens, CD1d; D006017:Glycolipids; D011948:Receptors, Antigen, T-Cell; D007371:Interferon-gamma