title: Alternative splicings on p53, BRCA1 and PTEN genes involved in breast cancer.
abstract: Alternative splicing is a major contributor to transcriptome and proteome diversity, which can lead to the deregulation of crucial cellular processes and have been associated with a variety of human diseases including cancer. As p53, BRCA1, and PTEN proteins have a key role in preventing breast cancer formation, cancer-associated splicing variants of these tumor suppressor genes are potential molecular markers and may contribute to the development of diagnostic and prognostic methods. In the present review, we summarize these tumor suppressor genes at a viewpoint of alternative splicing involved in breast cancer.
authors: Department of Environmental Health Science, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, Japan.
authors: Naoko
authors: N
authors: Okumura
authors: Hitomi
authors: H
authors: Yoshida
authors: Yasuko
authors: Y
authors: Kitagishi
authors: Yuri
authors: Y
authors: Nishimura
authors: Satoru
authors: S
authors: Matsuda
mesh_terms: D017398:Alternative Splicing; D019313:BRCA1 Protein / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051059:PTEN Phosphohydrolase / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D011487:Protein Conformation; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism
chemical_list: D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D020033:Protein Isoforms; D016159:Tumor Suppressor Protein p53; D051059:PTEN Phosphohydrolase