title: Initial recovery and rebound of type f intestinal colonization botulism after administration of investigational heptavalent botulinum antitoxin.
abstract: Investigational heptavalent botulinum antitoxin (HBAT) is now the primary antitoxin for US noninfant botulism patients. HBAT consists of equine Fab/F(ab')2 IgG fragments, which are cleared from circulation faster than whole immunoglobulins. Rebound botulism after antitoxin administration is not previously documented but occurred in our patient 10 days after HBAT administration.
authors: Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA. fev3@cdc.gov
authors: Ryan P
authors: RP
authors: Fagan
authors: Karen P
authors: KP
authors: Neil
authors: Randy
authors: R
authors: Sasich
authors: Carolina
authors: C
authors: Luquez
authors: Hakam
authors: H
authors: Asaad
authors: Susan
authors: S
authors: Maslanka
authors: Wajahat
authors: W
authors: Khalil
mesh_terms: D000368:Aged; D001904:Botulinum Antitoxin / Q000008:administration & dosage*; D001906:Botulism / Q000188:drug therapy* / Q000473:pathology*; D005260:Female; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000008:administration & dosage; D007074:Immunoglobulin G / Q000008:administration & dosage; D008657:Metabolic Clearance Rate; D012008:Recurrence; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States
chemical_list: D001904:Botulinum Antitoxin; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G