title: High p27 expression is associated with a better prognosis in East Asian non-small cell lung cancer patients.
abstract: BACKGROUND
  The role of the anti-apoptotic protein p27 in non-small cell lung cancer (NSCLC) remains controversial. To clarify its association with survival in NSCLC, we performed a systematic review of the literature with meta-analysis.
  
  
  METHODS
  Trials were selected for further analysis if they provided an independent assessment of p27 in NSCLC and reported the analysis of survival data based on p27 status. A total of 11 trials, which comprised 1646 patients, provided sufficient information for the meta-analysis. Sensitivity analyses were conducted using histology, disease stage and ethnicity.
  
  
  RESULTS
  The combined hazard ratio (HR) of 1.50 (95% CI=1.15-1.97; P<0.001 for heterogeneity) suggested that high p27 expression has a favorable impact on survival. When the studies were restricted to those of East Asian populations, patients that expressed high levels of p27 showed a better survival rate (HR 1.73, 95% CI=1.36-2.21; P=0.169 for heterogeneity) than those that did not express high levels of p27. In addition, the heterogeneity and publication bias disappeared.
  
  
  CONCLUSIONS
  In NSCLC, high p27 expression is associated with a better prognosis among East Asians.
authors: Department of Respiratory Medicine, the Affiliated DrumTower Hospital of Nanjing University Medical School, Nanjing, PR China.
authors: Yi
authors: Y
authors: Zhuang
authors: Hai-Tao
authors: HT
authors: Yin
authors: Xia-Li
authors: XL
authors: Yin
authors: Jing
authors: J
authors: Wang
authors: De-Ping
authors: DP
authors: Zhang
mesh_terms: D001208:Asia; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism* / Q000473:pathology; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D017594:Publication Bias; D016019:Survival Analysis
chemical_list: D050760:Cyclin-Dependent Kinase Inhibitor p27