title: Role and treatment of mitochondrial DNA-related mitochondrial dysfunction in sporadic neurodegenerative diseases.
abstract: Several sporadic neurodegenerative diseases display phenomena that directly or indirectly relate to mitochondrial function. Data suggesting altered mitochondrial function in these diseases could arise from mitochondrial DNA (mtDNA) are reviewed. Approaches for manipulating mitochondrial function and minimizing the downstream consequences of mitochondrial dysfunction are discussed.
authors: Department of Neurology, University of Kansas School of Medicine, Kansas City, 66160, USA. rswerdlow@kumc.edu
authors: Russell H
authors: RH
authors: Swerdlow
mesh_terms: D004272:DNA, Mitochondrial / Q000235:genetics*; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D006801:Humans; D008928:Mitochondria / Q000235:genetics* / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000188:drug therapy* / Q000378:metabolism*
chemical_list: D004272:DNA, Mitochondrial