title: Fenoterol did not enhance glucocorticoid-induced skeletal changes in male rats.
abstract: Glucocorticoids and β(2)-adrenergic receptor agonists are the most commonly used drugs in the treatment of asthma. Both therapies are potentially dangerous to the skeletal system. The aim of the present study was to investigate the effects of fenoterol, a β(2)-receptor agonist, on the development of bone changes induced by glucocorticoid (prednisolone) administration in mature male rats. The experiments were carried out on 24-week-old male Wistar rats. The effects of prednisolone 21-hemisuccinate sodium salt (7 mg/kg s.c. daily) or/and fenoterol hydrobromide (1.4 mg/kg i.p. daily), administered for 4 weeks, on the skeletal system were studied. Bone turnover markers, geometric parameters, mass, mass of bone mineral in the tibia, femur and L-4 vertebra, bone histomorphometric parameters and mechanical properties of tibial metaphysis, femoral diaphysis and femoral neck were determined. Both prednisolone and fenoterol had damaging effects on the skeletal system of mature male rats. However, concurrent administration of fenoterol and prednisolone did not result in the intensification of the deleterious skeletal effect of either drug administered separately.
authors: Department of Pharmacology, Medical University of Silesia, Katowice, Sosnowiec, Poland. jfolwarczna@sum.edu.pl
authors: Joanna
authors: J
authors: Folwarczna
authors: Barbara
authors: B
authors: Nowińska
authors: Leszek
authors: L
authors: Śliwiński
authors: Maria
authors: M
authors: Pytlik
authors: Urszula
authors: U
authors: Cegieła
authors: Anna
authors: A
authors: Betka
mesh_terms: D000135:Acid Phosphatase / Q000097:blood; D058666:Adrenergic beta-2 Receptor Agonists / Q000494:pharmacology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects*; D002113:Calcification, Physiologic / Q000187:drug effects; D018483:Diaphyses / Q000187:drug effects; D004347:Drug Interactions; D005269:Femur / Q000187:drug effects; D005280:Fenoterol / Q000009:adverse effects* / Q000494:pharmacology*; D005938:Glucocorticoids / Q000494:pharmacology*; D007527:Isoenzymes / Q000097:blood; D008297:Male; D011239:Prednisolone / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D000071681:Tartrate-Resistant Acid Phosphatase; D013977:Tibia / Q000187:drug effects
chemical_list: D058666:Adrenergic beta-2 Receptor Agonists; D005938:Glucocorticoids; D007527:Isoenzymes; D005280:Fenoterol; D011239:Prednisolone; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase