title: Subsequent alterations in the contractile property of the vas deferens according to duration of spermatic cord torsion.
abstract: OBJECTIVE
  To determine whether twisting of the ipsilateral vas deferens results in alteration of its contractility.
  
  
  METHODS
  Experimental study.
  
  
  METHODS
  University animal lab.
  
  
  METHODS
  24 male Wistar rats.
  
  
  METHODS
  All the rats in the experimental groups underwent spermatic cord torsion. Durations of torsion were 45 minutes, 3 hours, and 24 hours in groups 2, 3, and 4, respectively. In groups 2 and 3, subgroups b were created to evaluate late effects using in vitro pharmacological techniques.
  
  
  METHODS
  The contractility of the vas deferens was evaluated in groups 1, 2a, 3a, and 4 right after and in groups 2b and 3b 48 hours after the initial operation.
  
  
  RESULTS
  Group 4 and subgroups 2b and 3a had significantly diminished responses compared with the control group, whereas in subgroups 2a and 3b, the responses to noradrenaline and to single-pulse field stimulation were not significantly different.
  
  
  CONCLUSIONS
  The impairment of contractility with the twisting of the vas deferens might be another factor responsible for subfertility, particularly that related to sperm transport. The unfavorable late change in short duration of torsion may be the result of either ischemia and reperfusion injury or sympathetic overactivation in the acute period of torsion.
authors: Yeditepe University Faculty of Medicine, Department of Pediatric Surgery and Pediatric Urology, Istanbul, Turkey. safakkaracay@gmail.com
authors: Safak
authors: S
authors: Karacay
authors: Selami
authors: S
authors: Sözübir
authors: Sırrı S
authors: SS
authors: Bilge
authors: Elif
authors: E
authors: Aksoz
authors: Gulsen
authors: G
authors: Ekingen
authors: Bekir H
authors: BH
authors: Guvenç
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D005298:Fertility; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013086:Spermatic Cord Torsion / Q000503:physiopathology*; D013997:Time Factors; D014649:Vas Deferens / Q000187:drug effects / Q000294:innervation / Q000503:physiopathology*
chemical_list: D009638:Norepinephrine