title: Oral cholecalciferol versus ultraviolet radiation B: effect on vitamin D metabolites in patients with chronic pancreatitis and fat malabsorption - a randomized clinical trial.
abstract: BACKGROUND
  Patients with chronic pancreatitis (CP) often develop fat malabsorption and are susceptible to hypovitaminosis D.
  
  
  OBJECTIVE
  We wanted to evaluate the intestinal uptake of cholecalciferol in patients with CP and fat malabsorption.
  
  
  METHODS
  We did a prospective placebo-controlled study including patients with verified CP and fat malabsorption. They were randomized to 10 weeks of (A) ultraviolet radiation B (UVB) 6 min weekly in a commercial tanning bed, (B) vitamin D supplement 1,520 IU/daily, or (C) placebo. The vitamin D metabolites 25-hydroxyvitamin D (25OHD) and 1,25-dihydroxyvitamin D (calcitriol) were quantified at the start and end of the study.
  
  
  RESULTS
  In total 30 patients were randomized and 27 completed the study. Compliance to tablets and tanning sessions was >80%. The changes in 25OHD levels in group B (32.3 nmol/l; 95% CI 15-50) were significantly greater than changes in group A (p < 0.001) and group C (p < 0.001). Changes in group A (1.1 nmol/l) did not differ from the placebo group (p = 0.9). Changes in calcitriol levels were identical between groups.
  
  
  CONCLUSIONS
  Daily vitamin D supplements increased 25OHD in patients with CP compared to placebo whereas weekly tanning bed sessions did not.
authors: Department of Endocrinology, Hvidovre Hospital, Hvidovre, Denmark. ulrichbangbang@gmail.com
authors: Ulrich C
authors: UC
authors: Bang
authors: Peter
authors: P
authors: Matzen
authors: Thomas
authors: T
authors: Benfield
authors: Jens-Erik
authors: JE
authors: Beck Jensen
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D002762:Cholecalciferol / Q000008:administration & dosage* / Q000378:metabolism; D004041:Dietary Fats / Q000378:metabolism*; D010188:Exocrine Pancreatic Insufficiency / Q000378:metabolism / Q000628:therapy*; D005260:Female; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D050500:Pancreatitis, Chronic / Q000378:metabolism / Q000628:therapy*; D010349:Patient Compliance; D011878:Radiotherapy; D055108:Sunbathing; D014466:Ultraviolet Rays; D014467:Ultraviolet Therapy / Q000379:methods*; D014808:Vitamin D Deficiency / Q000378:metabolism / Q000628:therapy*; D014815:Vitamins / Q000008:administration & dosage* / Q000378:metabolism
chemical_list: D004041:Dietary Fats; D014815:Vitamins; D002762:Cholecalciferol