title: Reduction in serum high mobility group box-1 level by polymyxin B-immobilized fiber column in patients with idiopathic pulmonary fibrosis with acute exacerbation.
abstract: OBJECTIVE
  Recent reports suggest that polymyxin B (PMX)-immobilized fiber may have beneficial effects in idiopathic pulmonary fibrosis (IPF) with acute exacerbation (AE). High mobility group box-1 (HMGB-1) is an important pro-inflammatory mediator that contributes to acute lung inflammation. This study was aimed to investigate whether PMX treatment affects serum HMGB-1 levels and oxygenation in IPF patients with AE.
  
  
  METHODS
  Twenty IPF patients with AE were treated by PMX. PMX treatment was carried out once daily for 2 successive days. Serum HMGB-1 levels were measured before and after PMX treatment. We also monitored arterial oxygen tension (PaO(2))/inspiratory oxygen fraction (FiO(2)) (P/F) ratio. PMX fiber columns were analyzed to examine whether HMGB-1 was absorbed by PMX.
  
  
  RESULTS
  PMX treatment significantly improved both the serum HMGB-1 level and P/F ratio. HMGB-1 was detected in washing medium from the PMX column.
  
  
  CONCLUSIONS
  PMX treatment may reduce serum HMGB-1 and improve oxygenation in patients with IPF with AE.
authors: Department of Pulmonary Medicine/Infection and Oncology, Internal Medicine, Nippon Medical School, Tokyo, Japan. sabe @ nms.ac.jp
authors: Shinji
authors: S
authors: Abe
authors: Hiroki
authors: H
authors: Hayashi
authors: Yoshitsugu
authors: Y
authors: Seo
authors: Kuniko
authors: K
authors: Matsuda
authors: Koichiro
authors: K
authors: Kamio
authors: Yoshinobu
authors: Y
authors: Saito
authors: Jiro
authors: J
authors: Usuki
authors: Arata
authors: A
authors: Azuma
authors: Shoji
authors: S
authors: Kudo
authors: Akihiko
authors: A
authors: Gemma
mesh_terms: D000368:Aged; D005260:Female; D024243:HMGB1 Protein / Q000097:blood*; D006464:Hemoperfusion / Q000379:methods; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000097:blood* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000032:analysis; D011112:Polymyxin B / Q000737:chemistry / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D024243:HMGB1 Protein; D011112:Polymyxin B; D010100:Oxygen