title: Chemical engineering of Mycobacterium tuberculosis dodecin hybrids.
abstract: The suitability for chemical engineering of the highly symmetrical Mycobacterium tuberculosis dodecin was investigated, its inner cavity providing a large compartment shields introduced compounds from bulk solvent. Hybrids were obtained by S-alkylation of cysteine mutants and characterized by spectroscopic methods, including the crystal structures of wild type and biohybrid dodecins.
authors: Philipps-Universität Marburg, Fachbereich Chemie, Hans-Meerwein-Strasse, 35032 Marburg, Germany.
authors: Xenia
authors: X
authors: Vinzenz
authors: Wolfgang
authors: W
authors: Grosse
authors: Uwe
authors: U
authors: Linne
authors: Britta
authors: B
authors: Meissner
authors: Lars-Oliver
authors: LO
authors: Essen
mesh_terms: D000478:Alkylation; D001426:Bacterial Proteins / Q000737:chemistry*; D015195:Drug Design; D005420:Flavoproteins / Q000737:chemistry*; D008958:Models, Molecular; D009169:Mycobacterium tuberculosis; D055503:Protein Multimerization; D020836:Protein Structure, Quaternary
chemical_list: D001426:Bacterial Proteins; D005420:Flavoproteins