title: Synthesis of no-carrier-added 4-[18F]fluorophenol from 4-benzyloxyphenyl-(2-thienyl)iodonium bromide.
abstract: 4-[(18)F]Fluorophenol is a versatile synthon for the synthesis of more complex radiopharmaceuticals bearing a 4-[(18)F]fluorophenoxy moiety. In order to prepare 4-[(18)F]fluorophenol in no-carrier-added (n.c.a.) form only a nucleophilic labelling method starting from [(18)F]fluoride is suitable. In this paper a new, two step radiosynthesis starting from 4-benzyloxyphenyl-(2-thienyl)iodonium bromide and [(18)F]fluoride with subsequent deprotection is described, yielding n.c.a. [(18)F]fluorophenol in 34 to 36% radiochemical yield.
authors: Institute of Neuroscience and Medicine, INM-5: Nuclear Chemistry, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany.
authors: Tobias L
authors: TL
authors: Ross
authors: Johannes
authors: J
authors: Ermert
authors: Heinz H
authors: HH
authors: Coenen
mesh_terms: D005462:Fluorine Radioisotopes / Q000737:chemistry*; D009861:Onium Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010636:Phenols / Q000138:chemical synthesis*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C568719:4-benzyloxyphenyl-(2-thienyl)iodonium bromide; D005462:Fluorine Radioisotopes; D009861:Onium Compounds; D010636:Phenols; D019275:Radiopharmaceuticals; D013876:Thiophenes; C106880:4-fluorophenol