title: Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules.
abstract: Glyco (randomization/diversification) is a term that encompasses strategies to diversify a core drug scaffold via enzymatic glycosylation to provide sets of analogs wherein the sole diversity element is a carbohydrate. This review covers the influence of glycosylation upon various drug properties, the classes of glycosyl-conjugating enzymes amenable to glyco(randomization/diversification) schemes, approaches to the synthesis of required substrates and specific examples of glycorandomized libraries utilizing both wild-type and engineered enzymes.
authors: Pharmaceutical Sciences Division, School of Pharmacy, Wisconsin Center for Natural Products Research, University of Wisconsin-Madison, USA.
authors: Richard W
authors: RW
authors: Gantt
authors: Pauline
authors: P
authors: Peltier-Pain
authors: Jon S
authors: JS
authors: Thorson
mesh_terms: D001688:Biological Products / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D002241:Carbohydrates / Q000737:chemistry* / Q000493:pharmacokinetics; D055808:Drug Discovery; D006031:Glycosylation; D015394:Molecular Structure
chemical_list: D001688:Biological Products; D002241:Carbohydrates