title: Protective effect of Panax ginseng against serum biochemical changes and apoptosis in liver of rats treated with carbon tetrachloride (CCl4).
abstract: The purpose of this study was to investigate possible beneficial effects of Panax ginseng (PG) on carbon tetrachloride (CCl(4))-induced acute hepatotoxicity in rats. CCl(4) challenge elevated serum enzyme activities of liver and some biochemical parameters, but these effects were prevented by the pretreatment of rats with PG. Histologically, a great amount of mononuclear cells infiltration, necrotic cells and few fibroblasts were observed in liver of CCl(4) group. Also, CD68(+) and caspase-3 staining cells were diffused in both lobular and portal areas. However, PG pretreatment had a little influence on the number of caspase-3 immunopositive staining cells in the liver, but CD68(+) staining areas were significantly decreased in the PG+CCl(4) when compared to CCl(4) group. We conclude that PG treatment may play a protective role by enhancing liver enzyme activities and recovering biochemical parameters, and improving the changes in histological structure against CCl(4)-induced liver damages in rats.
authors: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Atatürk, 25240, Erzurum, Turkey.
authors: Emre
authors: E
authors: Karakus
authors: Ali
authors: A
authors: Karadeniz
authors: Nejdet
authors: N
authors: Simsek
authors: Ismail
authors: I
authors: Can
authors: Adem
authors: A
authors: Kara
authors: Serap
authors: S
authors: Yildirim
authors: Yildiray
authors: Y
authors: Kalkan
authors: Fikrullah
authors: F
authors: Kisa
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002251:Carbon Tetrachloride / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D007150:Immunohistochemistry; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D008297:Male; D005894:Panax; D051381:Rats; D017208:Rats, Wistar; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D002251:Carbon Tetrachloride; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase