title: Estimating effect of antiviral drug use during pandemic (H1N1) 2009 outbreak, United States.
abstract: From April 2009 through March 2010, during the pandemic (H1N1) 2009 outbreak, ≈8.2 million prescriptions for influenza neuraminidase-inhibiting antiviral drugs were filled in the United States. We estimated the number of hospitalizations likely averted due to use of these antiviral medications. After adjusting for prescriptions that were used for prophylaxis and personal stockpiles, as well as for patients who did not complete their drug regimen, we estimated the filled prescriptions prevented ≈8,400-12,600 hospitalizations (on the basis of median values). Approximately 60% of these prevented hospitalizations were among adults 18-64 years of age, with the remainder almost equally divided between children 0-17 years of age and adults >65 years of age. Public health officials should consider these estimates an indication of success of treating patients during the 2009 pandemic and a warning of the need for renewed planning to cope with the next pandemic.
authors: Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
authors: Charisma Y
authors: CY
authors: Atkins
authors: Anita
authors: A
authors: Patel
authors: Thomas H
authors: TH
authors: Taylor
authors: Matthew
authors: M
authors: Biggerstaff
authors: Toby L
authors: TL
authors: Merlin
authors: Stephanie M
authors: SM
authors: Dulin
authors: Benjamin A
authors: BA
authors: Erickson
authors: Rebekah H
authors: RH
authors: Borse
authors: Robert
authors: R
authors: Hunkler
authors: Martin I
authors: MI
authors: Meltzer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000188:drug therapy* / Q000453:epidemiology / Q000821:virology; D008875:Middle Aged; D053139:Oseltamivir / Q000627:therapeutic use; D058873:Pandemics; D055553:Prescription Drugs / Q000627:therapeutic use*; D014481:United States / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D055553:Prescription Drugs; D053139:Oseltamivir