title: Effects of diet on high-density lipoprotein cholesterol.
abstract: Multiple dietary factors have been shown to increase high-density lipoprotein cholesterol (HDL-C) concentrations, and HDL-C has been inversely associated with coronary heart disease (CHD) risk. Replacement of dietary carbohydrate with polyunsaturated, monounsaturated and saturated fat has been associated with progressively greater increases in HDL-C (7-12%) in addition to other lipid changes. Added sugars, but not high glycemic carbohydrates, have been associated with decreased HDL-C. Alcohol consumption has been associated with increased HDL-C (9.2%) independent of changes in other measured lipids. Modest effects on HDL-C (~4-5%) among other lipid and non-lipid CHD risk factors have also been observed with weight loss by dieting, omega-3 fatty acids, and a Mediterranean diet pattern. The CHD benefit of increasing HDL-C is unclear given the inconsistent evidence from HDL-raising pharmacologic trials. Furthermore, pleiotropic effects of diet preclude attribution of CHD benefit specifically to HDL-C. Investigation into functional or other properties of HDL may lend further insight.
authors: Atherosclerosis Research, Children's Hospital Oakland Research Institute, 5700 Martin Luther King Junior Way, Oakland, CA 94609, USA. psiri@chori.org
authors: Patty W
authors: PW
authors: Siri-Tarino
mesh_terms: D000428:Alcohol Drinking; D008076:Cholesterol, HDL / Q000097:blood*; D003327:Coronary Disease / Q000097:blood; D004032:Diet; D050528:Diet, Carbohydrate-Restricted; D038441:Diet, Mediterranean; D004038:Diet, Reducing; D004041:Dietary Fats; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology; D006801:Humans; D024821:Metabolic Syndrome / Q000097:blood; D012307:Risk Factors; D015431:Weight Loss
chemical_list: D008076:Cholesterol, HDL; D004041:Dietary Fats; D015525:Fatty Acids, Omega-3