title: Protective effects of apricot kernel oil on myocardium against ischemia-reperfusion injury in rats.
abstract: The present study was undertaken to evaluate the potential cardioprotective effects of apricot kernel oil (AO) on the myocardial ischemia-reperfusion (IR) of rat model in vivo. The rats were divided into five groups: sham-operated, IR, low dose AO-treated IR (LD-AO+IR), medium dose AO-treated IR (MD-AO+IR) and high dose AO-treated IR (HD-AO+IR). All rats were provided with food and water ad libitum. The LD-AO+IR, MD-AO+IR and HD-AO+IR groups were given a daily dose of 2, 6 and 10 ml kg(-1)BW(-1) of AO, respectively, for 14 days prior to the IR operation. Tetrazolium chloride staining revealed that infarct size and the ratio of infarct weight to the total heart weight were decreased significantly in the three AO-treated groups compared to the IR group. The serum creatine kinase and aspartate aminotransferase activities also demonstrated similar beneficial effects. Myocardial catalase, superoxide dismutase, glutathione peroxidase, and constitutive nitric oxide synthase activities, as well as NO concentrations, were all increased, whereas malondialdehyde content and inducible nitric oxide synthase were decreased in AO-treated rats. These findings suggest that apricot kernel oil has potent cardioprotective effects, and could be developed as a nutriment for the treatment and prevention of myocardial infarcts.
authors: Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Materials Science, Shaanxi Normal University, Xi'an 710062, China.
authors: Jing
authors: J
authors: Zhang
authors: Hong-Di
authors: HD
authors: Gu
authors: Li
authors: L
authors: Zhang
authors: Zhen-Jun
authors: ZJ
authors: Tian
authors: Zhi-Qi
authors: ZQ
authors: Zhang
authors: Xiu-Chao
authors: XC
authors: Shi
authors: Wen-Hong
authors: WH
authors: Ma
mesh_terms: D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002316:Cardiotonic Agents / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D003402:Creatine Kinase / Q000097:blood; D005979:Glutathione Peroxidase / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D023421:Models, Animal; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D010938:Plant Oils / Q000494:pharmacology*; D027861:Prunus / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D002316:Cardiotonic Agents; D010938:Plant Oils; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D052247:Nitric Oxide Synthase Type II; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase