title: Effect of mangiferin, a naturally occurring glucoxylxanthone, on fear memory in rats.
abstract: Mangiferin (1,3,6,7-tetrahydroxy-2-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] -xanthen-9-one, CAS 4773-96-0), a naturally occurring glucosylxanthone, is widely distributed in higher plants and a constituent of folk medicine. In the present study the effect of systemic administration of mangiferin on behavioural outcomes of neurological function in normal rats was investigated. A single intraperitoneal injection of mangiferin (10, 50 and 100 mg/kg body weight) immediately post-training produced an impairment of long-term memory for aversive training and a reduced freezing in a dose independent manner, when given immediately post-training. The administration of mangiferin 6 h post-training did not affect fear memory. The results indicate that mangiferin might induce deficits of emotionally motivated memory.
authors: Centro de Estudio para las Investigaciones y Evaluaciones Biológicas, Instituto de Farmacia y Alimentos, Universidad de La Habana, Cuba. gilbertopardo@infomed.sld.cu
authors: Gilberto L Pardo
authors: GL
authors: Andreu
authors: Natasha
authors: N
authors: Maurmann
authors: Gustavo Kellermann
authors: GK
authors: Reolon
authors: Caroline Brunetto
authors: CB
authors: de Farias
authors: René
authors: R
authors: Delgado
authors: Rafael
authors: R
authors: Roesler
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003672:Defecation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects; D005239:Fear / Q000187:drug effects* / Q000523:psychology*; D007202:Indicators and Reagents; D007274:Injections, Intraperitoneal; D008297:Male; D008568:Memory / Q000187:drug effects*; D009042:Motivation / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D044004:Xanthones / Q000494:pharmacology*
chemical_list: D007202:Indicators and Reagents; D044004:Xanthones; C013592:mangiferin