title: 'On periodical depressions and their pathogenesis' by Carl Lange (1886).
abstract: Carl Lange was the founding father of neurology in Denmark, authoring several pioneering works within this field; however, these remained largely unknown internationally as he did not have them translated into a major language. He became a pioneer of psychophysiology with his contribution to the so-called James-Lange theory of emotion. His treatise on'periodical depressions' ('the Lange theory of depressions', 1886), is not only an early historical landmark but also a masterly 'modern' description concerning the nosology and nosography of recurrent depressions. Moreover, it is a landmark in the early history of lithium therapy, sadly ignored by Lange's contemporaries, but which little more than half a century later, with Cade's rediscovery of lithium's therapeutic effect in mood disorders in 1949, ushered in modern psychopharmacology.
authors: Johann
authors: J
authors: Schioldann
mesh_terms: D000928:Antidepressive Agents / Q000266:history*; D001714:Bipolar Disorder / Q000266:history*; D003718:Denmark; D003866:Depressive Disorder / Q000266:history*; D004644:Emotions; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D016651:Lithium Carbonate / Q000266:history*; D009462:Neurology / Q000266:history*; D010507:Periodicity; D011603:Psychophysiology / Q000266:history*
chemical_list: D000928:Antidepressive Agents; D016651:Lithium Carbonate