title: A review of oxidative stress related genes and new antioxidant therapy in diabetic nephropathy.
abstract: A genetic component of diabetes and its complications (including diabetic nephropathy (DN)) is obvious, but the causative genes and mechanisms have not yet been satisfactorily identified. Oxidative stress is a single mechanism relating all major pathways responsible for diabetic damage. Numerous oxidative stress-related genes are positional candidates (determined by GWAS) and candidate genes studies confirm the association of their polymorphisms with DN. We present here their overview and connection to the "new antioxidant" therapy principle.
authors: Slovenj Gradec General Hospital, Department of Internal Medicine, Slovenj Gradec, Slovenia.
authors: Jana
authors: J
authors: Makuc
authors: Danijel
authors: D
authors: Petrovič
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D003928:Diabetic Nephropathies / Q000188:drug therapy* / Q000235:genetics*; D055106:Genome-Wide Association Study; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects*
chemical_list: D000975:Antioxidants