title: Replication of a genome-wide association study of birth weight in preterm neonates.
abstract: OBJECTIVE
  To examine associations between rs9883204 in ADCY5 and rs900400 near LEKR1 and CCNL1 with birth weight in a preterm population. Both markers were associated with birth weight in a term population in a recent genome-wide association study of Freathy et al.
  
  
  METHODS
  A meta-analysis of mother and infant samples was performed for associations of rs900400 and rs9883204 with birth weight in 393 families from the US, 265 families from Argentina, and 735 mother-infant pairs from Denmark. Z-scores adjusted for infant sex and gestational age were generated for each population separately and regressed on allele counts. Association evidence was combined across sites by inverse-variance weighted meta-analysis.
  
  
  RESULTS
  Each additional C allele of rs900400 (LEKR1/CCNL1) in infants was marginally associated with a 0.069 SD lower birth weight (95% CI, -0.159 to 0.022; P = .068). This result was slightly more pronounced after adjusting for smoking (P = .036). No significant associations were identified with rs9883204 or in maternal samples.
  
  
  CONCLUSIONS
  These results indicate the potential importance of this marker on birth weight regardless of gestational age.
authors: Department of Pediatrics, University of Iowa, Iowa City, IA, USA.
authors: Kelli K
authors: KK
authors: Ryckman
authors: Bjarke
authors: B
authors: Feenstra
authors: John R
authors: JR
authors: Shaffer
authors: Elise N A
authors: EN
authors: Bream
authors: Frank
authors: F
authors: Geller
authors: Eleanor
authors: E
authors: Feingold
authors: Daniel E
authors: DE
authors: Weeks
authors: Enrique
authors: E
authors: Gadow
authors: Viviana
authors: V
authors: Cosentino
authors: Cesar
authors: C
authors: Saleme
authors: Hyagriv N
authors: HN
authors: Simhan
authors: David
authors: D
authors: Merrill
authors: Chin-To
authors: CT
authors: Fong
authors: Tamara
authors: T
authors: Busch
authors: Susan K
authors: SK
authors: Berends
authors: Belen
authors: B
authors: Comas
authors: Jorge L
authors: JL
authors: Camelo
authors: Heather
authors: H
authors: Boyd
authors: Cathy C
authors: CC
authors: Laurie
authors: David
authors: D
authors: Crosslin
authors: Qi
authors: Q
authors: Zhang
authors: Kimberly F
authors: KF
authors: Doheny
authors: Elizabeth
authors: E
authors: Pugh
authors: Mads
authors: M
authors: Melbye
authors: Mary L
authors: ML
authors: Marazita
authors: John M
authors: JM
authors: Dagle
authors: Jeffrey C
authors: JC
authors: Murray
mesh_terms: D001724:Birth Weight / Q000235:genetics*; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male