title: Heterotopic ossification following musculoskeletal trauma: modeling stem and progenitor cells in their microenvironment.
abstract: Heterotopic ossification (HO), characterized by the formation of mature bone in the soft tissues, is a complication that can accompany musculoskeletal injury, and it is a frequent occurrence within the military population that has experienced orthopaedic combat trauma. The etiology of this disease is largely unknown. Our laboratory has developed strategies to investigate the cellular and molecular events leading to HO using clinical specimens that were obtained during irrigation and debridement of musculoskeletal injuries. Our approach enables to study (1) the cell types that are responsible for pathological transformation and ossification, (2) the cell- and tissue-level signaling that induces the pathologic transformation, and (3) the effect of extracellular matrix topography and force transduction on HO progression. In this review, we will report on our findings in each of these aspects of HO etiology and describe our efforts to recapitulate our findings in an animal model for traumatic HO.
authors: National Institutes of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
authors: Youngmi
authors: Y
authors: Ji
authors: Gregory T
authors: GT
authors: Christopherson
authors: Matthew W
authors: MW
authors: Kluk
authors: Orna
authors: O
authors: Amrani
authors: Wesley M
authors: WM
authors: Jackson
authors: Leon J
authors: LJ
authors: Nesti
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D044127:Epigenesis, Genetic; D020869:Gene Expression Profiling; D006801:Humans; D039902:Multipotent Stem Cells / Q000502:physiology; D009141:Musculoskeletal System / Q000293:injuries*; D009999:Ossification, Heterotopic / Q000209:etiology* / Q000473:pathology; D012038:Regeneration; D013234:Stem Cells / Q000502:physiology*; D014945:Wound Healing