title: Clinical and molecular genetic factors affecting postoperative seizure control of 183 Chinese adult patients with low-grade gliomas.
abstract: OBJECTIVE
  Seizures are a common symptom of patients with primary brain tumors, particularly low-grade gliomas (LGGs). Poor seizure control after surgery has a great adverse impact on quality of life in these patients. The present study aimed to identify clinical and molecular genetic factors that influence postoperative seizure control.
  
  
  METHODS
  A series of 183 LGGs were analyzed by denaturing high-performance liquid chromatography (DHPLC) for 1p and 19q status and by immunohistochemical staining for expression of several molecular markers (P53, Ki-67, MMP-9 and MGMT), with particular emphasis on correlations with postoperative seizure control. Univariate and multivariate logistic regression analyses were used for statistic analysis.
  
  
  RESULTS
  Of the 183 patients, 134 (73.2%) patients presented with seizures. Most of oligodendrogliomas and oligoastrocytomas had LOH 1p and LOH 19q, which were rarely seen in combination in astrocytomas (P<0.001). Oligodendroglial tumors were more likely to locate in frontal lobe (P=0.011) and present calcification on MRI (P=0.024). Temporal location (P=0.014), and high expression of mutated P53 (P=0.011) were associated with astrocytomas. Patients achieved much better seizure control after gross-total resection (P<0.001) than after subtotal resection. Patients without LOH 19q were more likely to have poor seizure control (P=0.004) than those with this alteration. Ki-67 was an independent molecular marker predicting poor seizure control (P=0.016) if over expressed.
  
  
  CONCLUSIONS
  Gross total resection of the tumor, LOH 19q and low Ki-67 expression were associated with favorable seizure control after surgery for the patients with LGGs. The possible involvement of other factors should be investigated further.
authors: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors: G
authors: G
authors: You
authors: L
authors: L
authors: Huang
authors: P
authors: P
authors: Yang
authors: W
authors: W
authors: Zhang
authors: W
authors: W
authors: Yan
authors: Y
authors: Y
authors: Wang
authors: Z
authors: Z
authors: Bao
authors: S
authors: S
authors: Li
authors: S
authors: S
authors: Li
authors: G
authors: G
authors: Li
authors: T
authors: T
authors: Jiang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D001932:Brain Neoplasms / Q000150:complications / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D002878:Chromosomes, Human, Pair 1; D002888:Chromosomes, Human, Pair 19; D005260:Female; D005910:Glioma / Q000150:complications / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D006801:Humans; D019656:Loss of Heterozygosity; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012640:Seizures / Q000209:etiology / Q000235:genetics* / Q000473:pathology / Q000601:surgery