title: Novel taxa-4(20),12-diene and 2(3→20)abeotaxane from needles of Taxus canadensis.
abstract: A novel 6/8/6-membered taxane with a rare C-12(13)-double bond and rare 2(3→20)abeotaxane were isolated from the needles of Taxus canadensis. Their structures were characterized as 7β,9α,10β-triacetoxytaxa-4(20),12-diene-2α,5α,11β-triol (1) and 2α,7β,10β-triacetoxy-5α-hydroxy-2(3→20)abeotaxa-4(20),11-diene-9,13-dione (2) on the basis of 1D and 2D spectroscopic data. 1 is the first example of a natural taxane without substitution at both C-13 and C-14.
authors: College of Basic Medicine, Hebei Medical University, China.
authors: Zhi-Yu
authors: ZY
authors: Ni
authors: Yi-Bing
authors: YB
authors: Wu
authors: Man-Li
authors: ML
authors: Zhang
authors: Yu-Fang
authors: YF
authors: Wang
authors: Mei
authors: M
authors: Dong
authors: Françoise
authors: F
authors: Sauriol
authors: Chang-Hong
authors: CH
authors: Huo
authors: Qing-Wen
authors: QW
authors: Shi
authors: Yu-Cheng
authors: YC
authors: Gu
authors: Hiromasa
authors: H
authors: Kiyota
authors: Bin
authors: B
authors: Cong
mesh_terms: D000970:Antineoplastic Agents / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015394:Molecular Structure; D010936:Plant Extracts / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000473:pathology; D043823:Taxoids / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D020946:Taxus / Q000737:chemistry*; D017211:Treatment Failure; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D010936:Plant Extracts; D043823:Taxoids