title: Cytosine-phosphodiester-guanine oligodeoxynucleotide (CpG ODN)-capped hollow mesoporous silica particles for enzyme-triggered drug delivery.
abstract: We designed, for the first time, an enzyme-triggered drug delivery system that is based on cytosine-phosphodiester-guanine oligodeoxynucleotide (CpG ODN)-capped hollow mesoporous silica (HMS) particles as carriers. Fluorescein dye was used as a model drug, and the fluorescein loading, amino-grafting and CpG ODN capping were evaluated by UV/Vis analysis, zeta potential and N(2) adsorption-desorption measurements and gel electrophoresis. The fluorescein loading capacity and CpG ODN capping amount were 37.7 and 39.6 μg mg(-1), respectively at the weight ratio of 10 Dye/HMS-NH(2)/CpG ODN. Importantly, fluorescein release can be triggered by the addition of deoxyribonuclease I (DNase I) for CpG ODN degradation, and the release rate can also be controlled by changing the DNase I concentration. Therefore, it might be a promising controlled drug delivery system for application in the field of biomedicine and cancer therapy.
authors: School of Materials Science and Engineering, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai, 200093, PR China. zjf2412@163.com
authors: Yufang
authors: Y
authors: Zhu
authors: Wenjun
authors: W
authors: Meng
authors: Nobutaka
authors: N
authors: Hanagata
mesh_terms: D018899:CpG Islands; D003850:Deoxyribonuclease I / Q000378:metabolism*; D004337:Drug Carriers / Q000737:chemistry*; D019793:Fluorescein / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry; D009838:Oligodeoxyribonucleotides / Q000737:chemistry* / Q000378:metabolism; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D009838:Oligodeoxyribonucleotides; D012822:Silicon Dioxide; D003850:Deoxyribonuclease I; D019793:Fluorescein