title: Heterogeneous catalytic hydrogenation of unprotected indoles in water: a green solution to a long-standing challenge.
abstract: An environmentally benign procedure for the hydrogenation of unprotected indoles is described. The hydrogenation reaction is catalyzed by Pt/C and activated by p-toluenesulfonic acid in water as a solvent. The efficacy of the method is illustrated by the hydrogenation of a variety of substituted indoles to their corresponding indolines which were obtained in excellent yields.
authors: Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, Massachusetts 02125, USA.
authors: Aditya
authors: A
authors: Kulkarni
authors: Weihong
authors: W
authors: Zhou
authors: Béla
authors: B
authors: Török
mesh_terms: D001557:Benzenesulfonates / Q000737:chemistry; D002384:Catalysis; D006865:Hydrogenation; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D012997:Solvents; D014867:Water / Q000737:chemistry*
chemical_list: D001557:Benzenesulfonates; D007211:Indoles; D012997:Solvents; D014867:Water; C029501:4-toluenesulfonic acid