title: Elective partial nephrectomy is equivalent to radical nephrectomy in patients with clinical T1 renal cell carcinoma: results of a retrospective, comparative, multi-institutional study.
abstract: OBJECTIVE
  To compare the oncological outcomes of patients who underwent elective partial nephrectomy (PN) or radical nephrectomy (RN) for clinically organ-confined renal masses ≤7 cm in size (cT1).
  
  
  METHODS
  The records of 3480 patients with cT1N0M0 disease were extracted from a multi-institutional database and analyzed retrospectively.
  
  
  RESULTS
  In patients who underwent PN, the risk of clinical understaging was 3.2% in cT1a cases and 10.6% in cT1b cases. With regard to the cT1a patients, the 5- and 10-year cancer-specific survival (CSS) estimates were 94.7% and 90.4%, respectively, after RN and 96.1% and 94.9%, respectively, after PN (log-rank test: P = 0.01). With regard to cT1b patients, the 5-year CSS probabilities were 92.6% after RN and 90% after PN, respectively (log-rank test: P = 0.89). Surgical treatment failed to be an independent predictor of CSS on multivariable analysis, both for cT1a and cT1b patients. Interestingly, PN was oncologically equivalent to RN also in patients with pT3a tumours (log-rank test: P = 0.91).
  
  
  CONCLUSIONS
  Elective PN is not associated with an increased risk of recurrence and cancer-specific mortality in both cT1a and cT1b tumours. Data from the present study strongly support the use of partial nephrectomy in patients with clinically T1 tumours, according to the current recommendations of the international guidelines.
authors: University of Brescia, Brescia, Italy.
authors: Alessandro
authors: A
authors: Antonelli
authors: Vincenzo
authors: V
authors: Ficarra
authors: Roberto
authors: R
authors: Bertini
authors: Marco
authors: M
authors: Carini
authors: Giorgio
authors: G
authors: Carmignani
authors: Serena
authors: S
authors: Corti
authors: Nicola
authors: N
authors: Longo
authors: Giuseppe
authors: G
authors: Martorana
authors: Andrea
authors: A
authors: Minervini
authors: Vincenzo
authors: V
authors: Mirone
authors: Giacomo
authors: G
authors: Novara
authors: Sergio
authors: S
authors: Serni
authors: Claudio
authors: C
authors: Simeone
authors: Alchiede
authors: A
authors: Simonato
authors: Salvatore
authors: S
authors: Siracusano
authors: Alessandro
authors: A
authors: Volpe
authors: Filiberto
authors: F
authors: Zattoni
authors: Sergio Cosciani
authors: SC
authors: Cunico
mesh_terms: D002292:Carcinoma, Renal Cell / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D017558:Elective Surgical Procedures; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000379:methods; D015996:Survival Rate