title: Aging--RNA in development and disease.
abstract: Given that RNA is involved in virtually all biological processes, it is perhaps not surprising that several RNA-binding proteins are associated with aging and with different age-related disorders. Other articles in this volume will discuss some specific examples of diseases where RNA plays a role that are also associated with aging, such as cancer and inflammation, so here I will discuss some general aspects of how RNA changes with the aging process. I will also discuss some specific examples of RNA-binding proteins that are associated with age-dependent neurological diseases as these provide an interesting framework to examine how lifetime mutations might lead to a late onset disease, although the answers to these questions are still not well understood.
authors: Cell Biology and Gene Expression Unit, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA. cookson@mail.nih.gov
authors: Mark R
authors: MR
authors: Cookson
mesh_terms: D000375:Aging / Q000235:genetics*; D000818:Animals; D006801:Humans; D009422:Nervous System Diseases / Q000235:genetics*; D012313:RNA / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics
chemical_list: D016601:RNA-Binding Proteins; D012313:RNA