title: Simultaneous determination of ionic and neutral preservatives by inline dialysis-ion chromatography coupled with a hydrophobic-ion exchange mixed mode column.
abstract: A quantitative analysis was developed for eight acidic and neutral preservatives in foods and daily necessities using the inline dialysis-IC combined with hydrophobic anion-exchange separation. The eight preservatives were dialyzed by inline dialysis and separated on a hydrophobic anion exchange column. Under the optimized separation conditions, the detection limits (S/N = 3) for the eight preservatives were from 0.08 to 0.66 mg L(-1), moreover, a good linearity (R(2) > 0.998) for each preservative was obtained in the range to 100 mg L(-1). Although the dialysis rate of the neutral preservatives was not so high, a good repeatability (RSD, n = 8) of less than 1.5% for the eight preservatives was obtained. The inline dialysis-IC method was applied to the determination of the preservatives in foods and daily necessities. The preservatives were quantified without any interference. The proposed method will be useful for the determination of the preservatives in foods and daily necessities containing high concentration matrices.
authors: Metrohm Japan Ltd., 18-7-2 Ikenohata, Taitoh, Tokyo 110-0008, Japan. nakashima1855@metrohm.co.jp
authors: Yasuo
authors: Y
authors: Nakashima
authors: Seiichi
authors: S
authors: Suzuki
authors: Makiko
authors: M
authors: Yamazaki
authors: Yoshinori
authors: Y
authors: Inoue
authors: Yuta
authors: Y
authors: Fukatsu
authors: Atsushi
authors: A
authors: Yamamoto
mesh_terms: D002021:Buffers; D002852:Chromatography, Ion Exchange / Q000295:instrumentation / Q000379:methods*; D005520:Food Preservatives / Q000032:analysis* / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D007477:Ions / Q000737:chemistry; D057230:Limit of Detection; D015203:Reproducibility of Results; D012997:Solvents / Q000737:chemistry; D013997:Time Factors
chemical_list: D002021:Buffers; D005520:Food Preservatives; D007477:Ions; D012997:Solvents