title: [An extremely high serum methotrexate concentration associated with acute renal failure in a patient with acute lymphoblastic leukemia after conduction of high dose consolidation].
abstract: Acute renal failure (ARF) is one of rare and severe methotrexate (MT)-induced complications in patients with acute lymphoblastic leukemia. A case of MT-induced renal dysfunction with an extremely high serum MT concentration is reported. This toxicity required conduction of hemodiafiltration for extracorporeal MT elimination. The presence of homozygous mutation of methylene-tetrahydrofolate reductase reflects an individual metabolism of MT and its renal clearance.
authors: M A
authors: MA
authors: Pimenova
authors: A N
authors: AN
authors: Sokolov
authors: L S
authors: LS
authors: Biriukova
authors: E N
authors: EN
authors: Ustinova
authors: I I
authors: II
authors: Shaforostova
authors: I A
authors: IA
authors: Donskova
authors: R F
authors: RF
authors: Bogdanov
authors: E N
authors: EN
authors: Parovichnikova
authors: V G
authors: VG
authors: Savchenko
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000175:diagnosis / Q000517:prevention & control; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007677:Kidney Function Tests; D002955:Leucovorin / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008727:Methotrexate / Q000009:adverse effects / Q000097:blood* / Q000627:therapeutic use; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000188:drug therapy*; D012074:Remission Induction
chemical_list: D002955:Leucovorin; D008727:Methotrexate