title: Effects of daintain/AIF-1 on β cell dysfunction in INS-1 cells.
abstract: We investigated the effects of daintain/AIF-1, a novel inflammatory cytokine, on INS-1β cells. Cells incubated with daintain/AIF-1 showed decreased cell viability and glucose-stimulated insulin secretion, as well as upregulated apoptosis and NO production. These deleterious effects of daintain/AIF-1 indicate that daintain/AIF-1 plays important roles in the dysfunction of pancreatic β cells in type-1 diabetes.
authors: Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, China.
authors: Xinyuan
authors: X
authors: Huang
authors: Yanying
authors: Y
authors: Zhao
authors: Shaohui
authors: S
authors: Jia
authors: Dongjing
authors: D
authors: Yan
authors: Zhengwang
authors: Z
authors: Chen
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D002135:Calcium-Binding Proteins; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004268:DNA-Binding Proteins / Q000009:adverse effects* / Q000235:genetics / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D005434:Flow Cytometry; D005947:Glucose / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000187:drug effects* / Q000378:metabolism; D008840:Microfilament Proteins; D009569:Nitric Oxide / Q000096:biosynthesis; D011994:Recombinant Proteins / Q000009:adverse effects* / Q000235:genetics / Q000378:metabolism
chemical_list: C112986:AIF1 protein, human; D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; D007328:Insulin; D008840:Microfilament Proteins; D011994:Recombinant Proteins; D009569:Nitric Oxide; D005947:Glucose