title: Studies on the electrochemical behavior of thiazolidine and its applications using a flow-through chronoamperometric sensor based on a gold electrode.
abstract: The electrochemical behaviors of thiazolidine (tetrahydrothiazole) on gold and platinum electrodes were investigated in a Britton-Robinson buffer (pH 2.77-11.61), acetate buffer (pH 4.31), phosphate buffer solutions (pH 2.11 and 6.38) and methanol or acetonitrile containing various supporting electrolytes. Detection was based on a gold wire electrochemical signal obtained with a supporting electrolyte containing 20% methanol-1.0 mM of phosphate buffer (pH 6.87, potassium dihydrogen phosphate and dipotassium hydrogen phosphate) as the mobile phase. Comparison with results obtained with a commercial amperometric detector shows good agreement. Using the chronoamperometric sensor with the current at a constant potential, and measurements with suitable experimental parameters, a linear concentration from 0.05 to 16 mg L-1 was found. The limit of quantification (LOQ) of the method for thiazolidine was found to be 1 ng.
authors: Department of Medical Chemistry, Chia Nan University of Pharmacy and Science, 60 Erh-Jen Road, Section 1, Jen Te, Tainan 71743, Taiwan. e201466.wang@msa.hinet.net
authors: Lai-Hao
authors: LH
authors: Wang
authors: Wen-Jie
authors: WJ
authors: Li
mesh_terms: D002021:Buffers; D002138:Calibration; D002853:Chromatography, Liquid / Q000379:methods; D055664:Electrochemical Techniques / Q000295:instrumentation*; D004563:Electrochemistry; D004566:Electrodes; D004573:Electrolytes / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D010084:Oxidation-Reduction; D010984:Platinum / Q000737:chemistry; D053778:Thiazolidines / Q000737:chemistry*
chemical_list: D002021:Buffers; D004573:Electrolytes; D053778:Thiazolidines; D010984:Platinum; D006046:Gold