title: Association of -55CT polymorphism of UCP3 gene with fat distribution, cardiovascular risk factors and adipocytokines in patients with Type 2 diabetes mellitus.
abstract: OBJECTIVE
  Some studies have pointed to a role of uncoupling protein 3 (UCP3) in the regulation of fat distribution. The aim of our study was to investigate the influence of -55CT polymorphism of UCP3 gene on fat mass and adipocytokines in naïve patients with Type 2 diabetes mellitus.
  
  
  METHODS
  A population of 57 patients with Type 2 diabetes mellitus and obesity was analyzed in a cross-sectional study. Genotype of UCP3 gene -55CT was studied.
  
  
  RESULTS
  Forty-six patients (80.7%) had the 55CC genotype and 11 patients (19.3%) the 55CT genotype. Fat mass (39.1±15.4 vs 53.3±16.8 kg; p<0.05), weight (92.6±17.7 vs 106.3±17.3 kg; p<0.05), body mass index (36.2±6.5 vs 42.8±5.2 kg/m²; p<0.05), waist circumference (112.8±13.6 vs 127.9±12.3 cm; p<0.05), waist-to-hip ratio (0.96±0.1 vs 1.1±0.2; p<0.05), C reactive protein (6.1±5.1 vs 12.4±6.1 mg/dl; p<0.05) and leptin (92.8±86 vs 114±89 ng/ml; p<0.05) were higher in patients with mutant genotype than in those with wild genotype.
  
  
  CONCLUSIONS
  C reactive protein and fat mass were higher in the mutant group of -55 CT UCP3 gene diabetic patients than in wild type patients.
authors: Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain. dadluis@yahoo.es
authors: D A
authors: DA
authors: de Luis
authors: R
authors: R
authors: Aller
authors: O
authors: O
authors: Izaola
authors: M
authors: M
authors: González Sagrado
authors: R
authors: R
authors: Conde
mesh_terms: D050154:Adiposity; D000368:Aged; D050218:Body Fat Distribution; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D007473:Ion Channels / Q000235:genetics* / Q000378:metabolism; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D024101:Mitochondrial Proteins / Q000235:genetics* / Q000378:metabolism; D009154:Mutation; D009765:Obesity / Q000150:complications / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D000071247:Uncoupling Protein 3
chemical_list: D007473:Ion Channels; D020738:Leptin; D024101:Mitochondrial Proteins; C000604392:UCP3 protein, human; D000071247:Uncoupling Protein 3; D002097:C-Reactive Protein