title: A novel compound, L34, induced apoptosis in human gastric cancer cells.
abstract: Selectively apoptosis-targeting compounds in gastrointestinal cancers attract broad interest. Here, we investigated a synthetic sulfonamide, 4-bromo-N-(5-ethyl-5H-pyrido[4,3-b]indol-8-yl)benzenesulfonamide (L34). It showed high activity against gastric cancer cells SGC-7901, causing apoptosis, which was associated with downregulation of caspase-3 and XIAP, upegulation of cleaved caspase-3, and cleavage of PARP. Hence, L34 might be a potent chemotherapeutic agent against human gastric cancer.
authors: Second Clinical Medical College, Zhejiang Chinese Medical University, China.
authors: Yuchen
authors: Y
authors: Lin
authors: Yangling
authors: Y
authors: Li
authors: Guiyuan
authors: G
authors: Lu
authors: Jing
authors: J
authors: Chen
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D053148:Caspase 3 / Q000235:genetics / Q000378:metabolism*; D002470:Cell Survival / Q000187:drug effects; D015536:Down-Regulation; D005434:Flow Cytometry; D015870:Gene Expression / Q000187:drug effects*; D006801:Humans; D020128:Inhibitory Concentration 50; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism; D011065:Poly(ADP-ribose) Polymerases / Q000235:genetics / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D013449:Sulfonamides / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D014407:Tumor Cells, Cultured; D051636:X-Linked Inhibitor of Apoptosis Protein / Q000235:genetics / Q000378:metabolism*; D000096926:Benzenesulfonamides
chemical_list: D000970:Antineoplastic Agents; D053148:Caspase 3; D009363:Neoplasm Proteins; D011065:Poly(ADP-ribose) Polymerases; D013449:Sulfonamides; D051636:X-Linked Inhibitor of Apoptosis Protein; C569261:4-bromo-N-(5-ethyl-5H-pyrido(4,3-b)indol-8-yl)benzenesulfonamide; D000096926:Benzenesulfonamides