title: The Rh allele frequencies in Gaza city in Palestine.
abstract: BACKGROUND
  The Rh blood group system is the second most clinically significant blood group system. It includes 49 antigens, but only five (D, C, E, c and e) are the most routinely identified due to their unique relation to hemolytic disease of the newborn (HDN) and transfusion reactions. Frequency of the Rh alleles showed variation, with regard to race and ethnic.
  
  
  OBJECTIVE
  The purpose of the study was to document the Rh alleles' frequencies amongst males (M) and females (F) in Gaza city in Palestine.
  
  
  METHODS
  Two hundred and thirty-two blood samples (110 M and 122 F) were tested against monoclonal IgM anti-C,anti-c, anti-E, anti-e and a blend of monoclonal/polyclonal IgM/IgG anti-D. The expected Rh phenotypes were calculated using gene counting method.
  
  
  RESULTS
  The most frequent Rh antigen in the total sample was e, while the least frequent was E.The order of the combined Rh allele frequencies in both M and F was CDe > cDe > cde > CdE > cDE > Cde > CDE. A significant difference was reported between M and F regarding the phenotypic frequencies (P < 0.05). However, no significance (P > 0.05) was reported with reference to the observed and expected Rh phenotypic frequencies in either M or F students.
  
  
  CONCLUSIONS
  It was concluded that the Rh antigens, alleles and phenotypes in Gaza city have unique frequencies, which may be of importance to the Blood Transfusion Center in Gaza city and anthropology.
authors: Department of Laboratory Medicine, Faculty of Applied Medical Sciences,Al-Azhar University-Gaza, PO Box (1277), Gaza, Palestine.
authors: Younis Abed
authors: YA
authors: El-Wahhab Skaik