title: UBE3C genetic variations as potent markers of nasal polyps in Korean asthma patients.
abstract: The human ubiquitin protein ligase E3C (UBE3C) regulates airway inflammatory responses and is hypothesized to be associated with the presence of nasal polyps in asthma-related diseases. A total of 24 UBE3C single-nucleotide polymorphisms (SNPs) were genotyped in a 467 Korean asthma cohort that was stratified into more homogenous phenotypes of 114 aspirin-exacerbated respiratory disease subgroup and 353 aspirin-tolerant asthma (ATA) subjects. Association analysis revealed that 16 UBE3C SNPs were significantly associated with presence of nasal polyps in the overall asthma group (P=0.0008 and P(corr)=0.01; odds ratio (OR)=0.60). The strength of association from 10 polymorphisms was increased in the ATA subgroup (P=0.0002 and P(corr)=0.003; OR=0.49). In addition, UBE3C_ht1 was found to be consistently associated with nasal polyps in the overall asthmatics group (P=0.006) and the ATA phenotype (P=0.002; P(corr)=0.02) via a codominant mechanism. Our findings provide evidence that variations in UBE3C are potent genetic markers of nasal polyps development in Korean asthmatics and may contribute novel insights into the clinical relevance and potential involvement of UBE3C in respiratory deficiencies.
authors: Department of Life Science, Sogang University, Seoul, Republic of Korea.
authors: Charisse Flerida A
authors: CF
authors: Pasaje
authors: Jeong-Hyun
authors: JH
authors: Kim
authors: Byung-Lae
authors: BL
authors: Park
authors: Jong-Sook
authors: JS
authors: Park
authors: Soo-Taek
authors: ST
authors: Uh
authors: Mi-Kyeong
authors: MK
authors: Kim
authors: Choon-Sik
authors: CS
authors: Park
authors: Hyoung Doo
authors: HD
authors: Shin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D001249:Asthma / Q000150:complications*; D016022:Case-Control Studies; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000150:complications / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*; D055815:Young Adult
chemical_list: D005819:Genetic Markers; C555759:UBE3C protein, human; D044767:Ubiquitin-Protein Ligases