title: [Hypovitaminosis D in pediatric patients on renal replacement therapy].
abstract: BACKGROUND
  Hypovitaminosis D has a high prevalence among patients with chronic kidney disease (CKD).
  
  
  OBJECTIVE
  To determine the prevalence of 25 hydroxy vitamin D (25(OH) D) insufficiency and deficiency in pediatric patients on dialysis and kidney transplantation.
  
  
  METHODS
  Serum calcium and phosphorus, parathormone (PTH), alkaline phosphatases and 25 (OH)D were measured in 13 children on hemodialysis (HD), 18 on peritoneal dialysis (PD) and 53 that received an allograft (Tx), aged 9.8 ± 4.6 years (51% females).
  
  
  RESULTS
  Fifty four percent of patients had height Z score less than -1.88. Patients on HD had the lowest values. The average time of replacement therapy was 2.9 ± 2.8 years. Mean 25(OH)D levels in all was 18.7 ± 10.7ng/ml (HD: 21 ± 16.8, PD: 18.9 ± 8.5, Tx: 18.1 ± 9.72 ng/ml). Eighty eight percent of patients had levels below 30 ng/ml. Mean of serum calcium was 9.5 ± 0.64 mg/dl, serum phosphorus 5.03 ± 1.02 mg/dl, calcium-phosphorus product 48 ± 11.8 mg/dl and alkaline phosphatases 300.5 ± 171.3 IU/L. Average PTH values in dialyzed and Tx patients were 724.6 ± 640.5 and 107.7 ± 56.2 pg/ml, respectively (p < 0.001). A positive correlation between 25 (OH) D and calcium levels among PD patients was observed (r = 0.490, p = 0.04).
  
  
  CONCLUSIONS
  Hypovitaminosis D is highly prevalent among children on renal substitution therapy, regardless of the type of therapy used and the stage of renal failure.
authors: Departamento Pediatría y Cirugía Infantil Oriente, Universidad de Chile, Hospital Luis Calvo Mackenna, Santiago, Chile.
authors: Angela
authors: A
authors: Delucchi
authors: Claudia
authors: C
authors: Alarcón
authors: Francisco
authors: F
authors: Cano
authors: Ana María
authors: AM
authors: Lillo
authors: José Luis
authors: JL
authors: Guerrero
authors: Marta
authors: M
authors: Azócar
authors: Carolina
authors: C
authors: Abarzúa
authors: María José
authors: MJ
authors: Muñoz
authors: Germán
authors: G
authors: Iñiguez
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D002118:Calcium / Q000097:blood; D002648:Child; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications* / Q000628:therapy; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000097:blood; D015995:Prevalence; D017582:Renal Replacement Therapy; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000209:etiology*
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D; D010758:Phosphorus; C104450:25-hydroxyvitamin D; D000469:Alkaline Phosphatase; D002118:Calcium