title: [Blood pressure lowering efficacy of beta-blockers added to monotherapy with a thiazid or a calcium antagonist--a survey of a Cochrane review].
abstract: A blood pressure fall of 6-8/4-6 mmHg is seen when a beta-blocker is added to a thiazid or a calcium antagonist. Due to less protection against cardiovascular complications, most likely explained by an insufficient reduction in the central aortic blood pressure profile betablockers, especially atenolol, is no longer first choice treatment for hypertension, unless ischaemic heart disease or heart failure is present.
authors: Medicinsk Afdeling, Holbæk Sygehus, 4300 Holbæk, Denmark. hib@regionsjaelland.dk
authors: Hans
authors: H
authors: Ibsen
authors: Tage Lysbo
authors: TL
authors: Svendsen
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D019317:Evidence-Based Medicine; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D049993:Sodium Chloride Symporter Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D049993:Sodium Chloride Symporter Inhibitors