title: Apoptosis of HL-60 leukemia cells induced by carbazole alkaloids isolated from Murraya euchrestifolia.
abstract: We carried out primary screening of 13 carbazole alkaloids isolated from the plant species Murraya euchrestifolia (Rutaceae) on cell growth inhibition of the human leukemia cell line HL-60. Among them, murrayafoline-A (1) and murrayazolinine (7) exhibited significant growth suppression due to apoptosis mediated by the activation of the caspase-9/caspase-3 pathway.
authors: Department of Medicinal Chemistry, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan.
authors: Chihiro
authors: C
authors: Ito
authors: Masataka
authors: M
authors: Itoigawa
authors: Keisuke
authors: K
authors: Nakao
authors: Tomiyasu
authors: T
authors: Murata
authors: Norio
authors: N
authors: Kaneda
authors: Hiroshi
authors: H
authors: Furukawa
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002227:Carbazoles / Q000737:chemistry / Q000494:pharmacology; D053148:Caspase 3 / Q000378:metabolism; D053453:Caspase 9 / Q000378:metabolism; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D032101:Murraya / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D002227:Carbazoles; D010936:Plant Extracts; C041514:carbazole; D053148:Caspase 3; D053453:Caspase 9