title: Six-year prognosis of diabetic patients with coronary artery disease.
abstract: BACKGROUND
  Diabetes is associated with increased cardiovascular mortality. The aim of our study was to determine the prognostic factors for mortality in patients with type 2 diabetes (T2DM) and coronary artery disease (CAD) who underwent coronary angiography and percutaneous coronary intervention.
  
  
  METHODS
  Four hundred and forty-five consecutive T2DM patients with significant CAD (≥ 75% stenosis) were included in our analysis. All patients underwent standard clinical examination, laboratory tests and transthoracic echocardiography with measurement of the left ventricular ejection fraction. Severity of CAD at the coronary angiography was evaluated using the Gensini score. Clinical follow-up was completed at 1, 3 and 6 years.
  
  
  RESULTS
  During a mean follow-up of 73·3 ± 22·1 months, 109 patients died (24·5%). Significant determinants of an increased risk of death at multivariable analysis were age (p < 0·001), serum creatinine (p = 0·001), peripheral vascular disease (p = 0·002), serum glucose (p = 0·004), serum fibrinogen (p = 0·011) and history of heart failure (HF, p = 0·011). When all the variables were entered as categorical variables, with continuous variables split at their median value, only history of HF, estimated glomerular filtration rate, serum glucose, serum fibrinogen (all p < 0·0001) and beta-blocker therapy at discharge (p = 0·027) were selected.
  
  
  CONCLUSIONS
  Our study shows a relatively good prognosis of patients with T2DM. Comorbidities, namely HF and renal impairment, are main determinants of survival.
authors: Section of Cardiology, Department of Experimental and Applied Sciences, University of Brescia, Brescia, Italy.
authors: Savina
authors: S
authors: Nodari
authors: Alessandra
authors: A
authors: Manerba
authors: Alberto
authors: A
authors: Vaccari
authors: Giuseppe
authors: G
authors: Milesi
authors: Valentina
authors: V
authors: Carubelli
authors: Valentina
authors: V
authors: Lazzarini
authors: Carlo
authors: C
authors: Lombardi
authors: Federica
authors: F
authors: Ettori
authors: Marco
authors: M
authors: Metra
authors: Alessandra
authors: A
authors: Dei Cas
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012044:Regression Analysis; D012307:Risk Factors; D012720:Severity of Illness Index; D016019:Survival Analysis; D013997:Time Factors; D044465:White People