title: Containment of an outbreak of KPC-3-producing Klebsiella pneumoniae in Italy.
abstract: From March 2009 to May 2009, 24 carbapenem-resistant Klebsiella pneumoniae isolates were recovered from 16 patients hospitalized in an Italian intensive care unit (ICU). All isolates contained KPC-3 carbapenemase and belonged to a single pulsed-field gel electrophoresis (PFGE) clone of multilocus sequence type 258 (designated as ST258). A multimodal infection control program was put into effect, and the spread of the KPC-3-producing K. pneumoniae clone was ultimately controlled without closing the ICU to new admissions. Reinforced infection control measures and strict monitoring of the staff adherence were necessary for the control of the outbreak.
authors: Department GF Ingrassia, University of Catania, Catania, Italy.
authors: Antonella
authors: A
authors: Agodi
authors: Evangelia
authors: E
authors: Voulgari
authors: Martina
authors: M
authors: Barchitta
authors: Leda
authors: L
authors: Politi
authors: Vasiliki
authors: V
authors: Koumaki
authors: Nicholas
authors: N
authors: Spanakis
authors: Loredana
authors: L
authors: Giaquinta
authors: Giovanna
authors: G
authors: Valenti
authors: Maria Antonietta
authors: MA
authors: Romeo
authors: Athanassios
authors: A
authors: Tsakris
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000378:metabolism*; D015780:Carbapenems / Q000494:pharmacology; D016000:Cluster Analysis; D003428:Cross Infection / Q000453:epidemiology* / Q000517:prevention & control; D004196:Disease Outbreaks; D016521:Electrophoresis, Gel, Pulsed-Field; D006801:Humans; D017053:Infection Control / Q000379:methods*; D007362:Intensive Care Units; D007558:Italy / Q000453:epidemiology; D007710:Klebsiella Infections / Q000453:epidemiology* / Q000517:prevention & control; D007711:Klebsiella pneumoniae / Q000145:classification / Q000187:drug effects / Q000201:enzymology* / Q000302:isolation & purification; D058889:Molecular Typing; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; D001618:beta-Lactamases; C495220:beta-lactamase KPC-3, Klebsiella pneumoniae