title: [Influence of diurnal variation in the size of acute myocardial infarction].
abstract: OBJECTIVE
  To evaluate whether the size of acute myocardial infarction (AMI) shows circadian variability.
  
  
  METHODS
  An observational, prospective study.
  
  
  METHODS
  A 12-bed coronary care unit.
  
  
  METHODS
  Consecutive patients diagnosed with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention.
  
  
  METHODS
  The patients were divided into two groups according to the time of onset of AMI symptoms (Group A: 0-12hours, Group B: 12-24hours).
  
  
  METHODS
  Age, sex, cardiovascular risk factors, coronary anatomy, left ventricular ejection fraction, infarct location, time from onset of symptoms to reperfusion, presence of heart failure upon admission, and peak troponin I value.
  
  
  RESULTS
  A total of 108 patients with a diagnosis of STEMI were included. Patients in group A showed a higher troponin I concentration compared to group B (troponin I: 70.85±16.38 versus 60.90±22.92ng / ml, p=0.003). In the multivariate analysis the onset of AMI between 0-12hours was identified as an independent predictor of infarct size (OR: 1.133, 95%CI 1.012-1.267, p=0.01).
  
  
  CONCLUSIONS
  An onset of AMI between 0-12hours results in a significantly larger final size of necrosis compared with any other time of presentation.
authors: Servicio de Cardiología, Hospital Universitario de Canarias, Tenerife, España.
authors: E
authors: E
authors: Arroyo Úcar
authors: A
authors: A
authors: Dominguez-Rodriguez
authors: P
authors: P
authors: Abreu-Gonzalez
mesh_terms: D000368:Aged; D015415:Biomarkers; D002784:Cholesterol / Q000097:blood; D002940:Circadian Rhythm; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000453:epidemiology / Q000473:pathology* / Q000503:physiopathology; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D011446:Prospective Studies; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D013318:Stroke Volume; D013997:Time Factors; D019210:Troponin I / Q000097:blood
chemical_list: D015415:Biomarkers; D019210:Troponin I; D002784:Cholesterol; D003404:Creatinine