title: New drug-eluting stent implantation for recalcitrant in-stent restenosis treated with drug-eluting stents. the Stent-in-Stent Cube (SIS³) registry.
abstract: The best management for patients with recurrent in-stent restenosis is still not clear. The aim of the present study was to describe the long-term clinical results of re-DES (drug-eluting stent) implantation in patients suffering recurrences after stenting with DES for in-BMS (bare metal stent) restenosis.
  
  
  METHODS
  All consecutive patients with in-BMS restenosis treated with DES and presenting with recurrent ISR (in-DES restenosis) treated with re-DES in 3 tertiary care centers were retrospectively selected and analyzed.
  
  
  RESULTS
  In the time period 2005-2009, 40 consecutive patients with recalcitrant ISR were selected. At a mean follow-up of 701 ± 570 days, no patient died. The incidence of target lesion revascularization (TLR) and target vessel revascularization (TVR) was 12.5% and 17.5%, respectively. Survival free from composite endpoint (any death + MI + TLR) was 82% at 2 years.
  
  
  CONCLUSIONS
  DES implantation for patients with recurrent ISR offers good clinical outcomes at long-term follow-up.
authors: Interventional Cardiology Unit, Mauriziano Hospital, Largo Filippo Turati 62, Turin, Italy. emeliga@gmail.com
authors: Emanuele
authors: E
authors: Meliga
authors: Mauro
authors: M
authors: De Benedictis
authors: Andrea
authors: A
authors: Gagnor
authors: Innocenzo
authors: I
authors: Scrocca
authors: Primiano
authors: P
authors: Lombardi
authors: Tiziana
authors: T
authors: Aranzulla
authors: Ferdinando
authors: F
authors: Varbella
authors: Maria Rosa
authors: MR
authors: Conte
mesh_terms: D000368:Aged; D023903:Coronary Restenosis / Q000401:mortality / Q000517:prevention & control / Q000628:therapy*; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D012008:Recurrence; D012042:Registries; D012189:Retrospective Studies; D013318:Stroke Volume; D017211:Treatment Failure; D016277:Ventricular Function, Left