title: Patterns of herbal combination for the treatment of insomnia commonly employed by highly experienced Chinese medicine physicians.
abstract: OBJECTIVE
  To explore the most effective herbal combinations commonly used by highly experienced Chinese medicine (CM) physicians for the treatment of insomnia.
  
  
  METHODS
  We collected and analyzed data related to insomnia treatment from the clinics of 7 highly experienced CM physicians in Beijing. The sample included 162 patients and 460 consultations in total. Patient outcomes, such as sleep quality and sleep time per day, were manually collected from the medical records by trained CM clinicians. Three data mining methods, support vector machine (SVM), logistic regression and decision tree, and multifactor dimensionality reduction (MDR), were used to determine and confirm the herbal combinations that resulted in positive outcomes in patients suffering from insomnia.
  
  
  RESULTS
  Results show that MDR is the most efficient method to predict the effective herbal combinations. Using the MDR model, we identified several combinations of herbs with 100% positive outcomes, such as stir-fried spine date seed, Szechwan lovage rhizome, and prepared thinleaf milkwort root; white peony root, golden thread, and stir-fried spine date seed; and Asiatic cornelian cherry fruit with fresh rehmannia.
  
  
  CONCLUSIONS
  Results indicate that herbal combinations are effective treatments for patients with insomnia compared with individual herbs. It is also shown that MDR is a potent data mining method to identify the herbal combination with high rates of positive outcome.
authors: School of Computer and Information Technology, Beijing Jiaotong University, China.
authors: Xue-zhong
authors: XZ
authors: Zhou
authors: Run-shun
authors: RS
authors: Zhang
authors: Jatin
authors: J
authors: Shah
authors: Dimple
authors: D
authors: Rajgor
authors: Ying-hui
authors: YH
authors: Wang
authors: Ricardo
authors: R
authors: Pietrobon
authors: Bao-yan
authors: BY
authors: Liu
authors: Jie
authors: J
authors: Chen
authors: Jian-gui
authors: JG
authors: Zhu
authors: Rong-lin
authors: RL
authors: Gao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002983:Clinical Competence; D057225:Data Mining; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D010045:Outpatients; D010820:Physicians; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D004365:Drugs, Chinese Herbal