title: A status update of modified oligonucleotides for chemotherapeutics applications.
abstract: This unit presents an update of recent developments and clinical progress in chemically modified oliogonucleotides useful for therapeutic applications. During the last decade, the number of therapeutic oligonucleotides in clinical trials has nearly tripled. This is primarily due to advances in the synthesis protocols, better understanding of the biology, improved delivery, and better formulation technologies. Currently, over 100 clinical trials with oligonucleotide-based drugs are ongoing in the United States for potential treatment of a variety of life-threatening diseases. Among various oligonucleotides, antisense technology has been at the forefront, with one product on the market. Antisense technologies represent about half of the active clinical trials. Similarly, siRNA, aptamers, spiegelmers microRNA, shRNA, IMO, and CpG have been other active classes of oligonucleotides that are also undergoing clinical trials. This review attempts to summarize the current status of synthesis, chemical modifications, purification, and analysis in light of the rapid progress with multitude of oligonucleotides pursued as therapeutic modality.
authors: Rasayan Inc, Encinitas, California, USA.
authors: Yogesh S
authors: YS
authors: Sanghvi
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D018899:CpG Islands; D015195:Drug Design; D004345:Drug Industry; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000627:therapeutic use*; D016376:Oligonucleotides, Antisense / Q000627:therapeutic use; D034741:RNA, Small Interfering / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense; D034741:RNA, Small Interfering