title: Clinical and experimental experiences of graft-induced dyskinesia.
abstract: Clinical trials evaluating transplantation of fetal tissue for the treatment of Parkinson's disease identified the unexpected side effect of abnormal movements in the 'off'l-DOPA state. Termed graft-induced dyskinesia (GID), various hypotheses have been put forward as to their cause but unfortunately the significant differences in clinical trial protocols and lack of a truly representative animal model has hindered the search for a conclusive basis for their appearance. Likely causative factors have been identified through careful examination of patient data and the use of amphetamine-induced dyskinesia in a rodent model of Parkinson's disease. New trials being planned in Europe hope to avoid GID, whilst maximizing on the functional benefit that can be afforded by this treatment approach but questions still remain as to the underlying mechanism.
authors: Welsh School of Pharmacy, Cardiff University, Cardiff CF10 3NB, UK.
authors: Emma L
authors: EL
authors: Lane
mesh_terms: D000818:Animals; D016380:Brain Tissue Transplantation / Q000009:adverse effects*; D004195:Disease Models, Animal; D020820:Dyskinesias / Q000209:etiology*; D006801:Humans; D016627:Oxidopamine / Q000633:toxicity; D010300:Parkinson Disease / Q000601:surgery; D019737:Transplants / Q000009:adverse effects*
chemical_list: D016627:Oxidopamine