title: Late-onset OCD as presenting manifestation of semantic dementia.
abstract: Semantic dementia (SD) is a neurodegenerative disease belonging to the spectrum of frontotemporal dementia that presents with loss of memory for words and prevalent left temporal pole atrophy. Behavioral disorders, particularly obsessive-compulsive symptoms, are frequent during the course of the disease. We describe a patient presenting with late-onset typical obsessive-compulsive disorder (OCD) that lasted for 10 years as an isolated condition before developing clinical and neuroimaging features of SD. This case alerts clinicians that late-onset OCD may be a psychiatric presentation of a neurodegenerative disorder such as frontotemporal dementia and requires an accurate diagnostic work-up.
authors: Department of Neurosciences, University of Padova, 35128 Padova, Italy.
authors: Sara
authors: S
authors: Pompanin
authors: Giulia
authors: G
authors: Perini
authors: Tommaso
authors: T
authors: Toffanin
authors: Francesca
authors: F
authors: Gnoato
authors: Diego
authors: D
authors: Cecchin
authors: Renzo
authors: R
authors: Manara
authors: Annachiara
authors: A
authors: Cagnin
mesh_terms: D017668:Age of Onset; D057174:Frontotemporal Lobar Degeneration / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis* / Q000503:physiopathology; D011859:Radiography