title: [Prevalence of bacterial infections and patterns of bacterial susceptibility among patients with fever, neutropenia, and hematological neoplasias].
abstract: Chemotherapy induces immunosuppression which is associated with a significant increase in the frequency and severity of infections. Neutropenia is the most important factor in determining susceptibility to bacterial infections. Our aim was to establish the prevalence of bacterial infections and bacterial susceptibility patterns in patients with fever, neutropenia and hematological neoplasias. Cultures were obtained prior empirical antimicrobial treatment. Susceptibility tests to antibiotics were performed for all microorganisms considered pathogens. Descriptive statistics were used for each variable. Differences between proportions were estimated by means of χ2 or Fisher's exact test. We included 85 patients.Primary bacteremia was the most frequent cause of fever (52%). Microorganisms most frequently isolated were:S. epidermidis (54.2%), E. coli (12.5%), S. aureus (8.3%). In susceptibility tests 88.5% of S. epidermidis strains were resistant to oxaciline (MIC > 8 μ/ml); E. coli was resistant to ceftazidime (50%) and trimethroprim/sulfamethoxazole (83%).In conclusion, gram-positive microorganisms are predominant in patients with fever and neutropenia followed by gram-negatives like E. coli. Predominance of gram-positives microorganism forces us to reconsider our current prophylactic and therapeutic antimicrobials regimens used in these patients.
authors: Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, México.
authors: Jesús
authors: J
authors: Gaytán-Martínez
authors: Maribel
authors: M
authors: Avila-Morán
authors: José Antonio
authors: JA
authors: Mata-Marín
authors: Eduardo
authors: E
authors: Mateos-García
authors: José Luis
authors: JL
authors: Fuentes-Allen
authors: Jorge
authors: J
authors: Vela-Ojeda
authors: Abraham
authors: A
authors: Majluf-Cruz
authors: Jaime
authors: J
authors: García-Chávez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology* / Q000209:etiology / Q000382:microbiology; D005334:Fever / Q000150:complications; D019337:Hematologic Neoplasms / Q000150:complications; D006801:Humans; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009503:Neutropenia / Q000150:complications; D015995:Prevalence; D011446:Prospective Studies