title: Multifocal oligodendroglioma in three dogs.
abstract: This report describes the clinical, histopathologic, and imaging findings of multifocal oligodendrogliomas from three canine patients. Clinical history varied but included seizure activity and behavior changes. Neurologic examination abnormalities included ataxia, proprioceptive deficits, cranial nerve deficits, and changes in mentation. MRI in one patient revealed multifocal brain lesions; however, the MRI was normal in another one of the patients. Histopathologic evaluation identified multifocal neoplastic infiltrates in all three patients involving the cerebral cortex, brainstem, and spinal cord, with leptomeningeal extension in two of the three patients. All three patients were euthanized due to progression of their neurologic condition and/or complications due to aspiration pneumonia. Oligodendrogliomas should be considered a differential diagnosis for patients with multifocal brain disease.
authors: Department of Clinical Studies, Internal Medicine Section, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
authors: Michael W
authors: MW
authors: Koch
authors: Melissa D
authors: MD
authors: Sánchez
authors: Sam
authors: S
authors: Long
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000175:diagnosis / Q000662:veterinary*; D001933:Brain Stem; D002540:Cerebral Cortex; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000473:pathology; D004285:Dogs; D005260:Female; D008279:Magnetic Resonance Imaging / Q000662:veterinary; D008297:Male; D009460:Neurologic Examination / Q000662:veterinary; D009837:Oligodendroglioma / Q000175:diagnosis / Q000662:veterinary*; D013120:Spinal Cord Neoplasms / Q000175:diagnosis / Q000662:veterinary*