title: Comparative pharmacokinetics of perfluorooctanesulfonate (PFOS) in rats, mice, and monkeys.
abstract: Perfluorooctanesulfonate (PFOS) has been found in biological samples in wildlife and humans. The geometric mean half-life of serum elimination of PFOS in humans has been estimated to be 4.8 years (95% CI, 4.0-5.8). A series of studies was undertaken to establish pharmacokinetic parameters for PFOS in rats, mice, and monkeys after single oral and/or IV administration of K(+)PFOS. Animals were followed for up to 23 weeks, and pharmacokinetic parameters were determined by WinNonlin® software. Rats and mice appeared to be more effective at eliminating PFOS than monkeys. The serum elimination half-lives in the rodent species were on the order of 1-2 months; whereas, in monkeys, the serum elimination half lives approximated 4 months. Collectively, these studies provide valuable insight for human health risk assessment regarding the potential for accumulation of body burden in humans on repeated exposure to PFOS and PFOS-generating materials.
authors: Medical Department, 3M Company, 3M Center 220-06-W-08, St. Paul, MN 55144, United States. Electronic address: s.chang@mmm.com.
authors: Shu-Ching
authors: SC
authors: Chang
authors: Southern Research Institute, Birmingham, AL 35255, United States. Electronic address: noker@southernresearch.org.
authors: Patricia E
authors: PE
authors: Noker
authors: Southern Research Institute, Birmingham, AL 35255, United States; Samford University, Birmingham, AL 35229, United States. Electronic address: ggorman@samford.edu.
authors: Gregory S
authors: GS
authors: Gorman
authors: Medical Department, 3M Company, 3M Center 220-06-W-08, St. Paul, MN 55144, United States. Electronic address: sjgibson@mmm.com.
authors: Sheila J
authors: SJ
authors: Gibson
authors: Medical Department, 3M Company, 3M Center 220-06-W-08, St. Paul, MN 55144, United States. Electronic address: jahart@mmm.com.
authors: Jill A
authors: JA
authors: Hart
authors: Medical Department, 3M Company, 3M Center 220-06-W-08, St. Paul, MN 55144, United States. Electronic address: djehresman@mmm.com.
authors: David J
authors: DJ
authors: Ehresman
authors: Medical Department, 3M Company, 3M Center 220-06-W-08, St. Paul, MN 55144, United States. Electronic address: jlbutenhoff@mmm.com.
authors: John L
authors: JL
authors: Butenhoff
mesh_terms: D000284:Administration, Oral; D017738:Alkanesulfonic Acids / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D000818:Animals; D004785:Environmental Pollutants / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D005243:Feces / Q000737:chemistry; D005260:Female; D005466:Fluorocarbons / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D006207:Half-Life; D007275:Injections, Intravenous; D008099:Liver / Q000378:metabolism; D008252:Macaca fascicularis; D008297:Male; D008657:Metabolic Clearance Rate; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D017207:Rats, Sprague-Dawley; D013045:Species Specificity; D014018:Tissue Distribution
chemical_list: D017738:Alkanesulfonic Acids; D004785:Environmental Pollutants; D005466:Fluorocarbons; C076994:perfluorooctane sulfonic acid