title: Metabolic signature of pregnant women with neural tube defects in offspring.
abstract: Neural tube defects (NTDs) are one of the most common types of birth defects, affecting approximately 1 of every 1000 pregnancies in the United States and an estimated 300 000 newborns worldwide each year. The metabolic signature of pregnant women with NTDs in offspring has not previously been characterized. In this paper, we report a profiling study that characterized the serum metabolome of 101 pregnant women affected with NTDs in offspring in comparison with 143 pregnant women with normal pregnancy outcomes in Lvliang prefecture, the area with the highest birth prevalence of NTDs in China. A serum metabonomic study was also conducted to identify significantly altered metabolites associated with di-n-butyl phthalate (DBP)-induced teratogenesis in mice. The metabolic signature of NTD in pregnant women is characterized by the impaired mitochondrial respiration, neurotransmitter γ-aminobutyric acid, and methionine cycle. Of interest, consistent findings from DBP-induced teratogenesis in mice demonstrated increased succinate and decreased fumarate, suggesting an inhibited succinic dehydrogenase implicated in the defective mitochondria. The characteristic disruption of maternal metabolism offers important insights into metabolic mechanisms underlying human NTDs as well as potential preventive strategies.
authors: WHO Collaborating Center for Reproductive Health and Population Science, Beijing, PR China.
authors: Xiaoying
authors: X
authors: Zheng
authors: Mingming
authors: M
authors: Su
authors: Lijun
authors: L
authors: Pei
authors: Ting
authors: T
authors: Zhang
authors: Xu
authors: X
authors: Ma
authors: Yunping
authors: Y
authors: Qiu
authors: Hongfei
authors: H
authors: Xia
authors: Fang
authors: F
authors: Wang
authors: Xiaojiao
authors: X
authors: Zheng
authors: Xue
authors: X
authors: Gu
authors: Xinming
authors: X
authors: Song
authors: Xin
authors: X
authors: Li
authors: Xin
authors: X
authors: Qi
authors: Gong
authors: G
authors: Chen
authors: Yihua
authors: Y
authors: Bao
authors: Tianlu
authors: T
authors: Chen
authors: Yi
authors: Y
authors: Chi
authors: Aihua
authors: A
authors: Zhao
authors: Wei
authors: W
authors: Jia
mesh_terms: D000328:Adult; D000818:Animals; D002681:China; D003993:Dibutyl Phthalate; D005260:Female; D005492:Folic Acid / Q000378:metabolism; D005786:Gene Expression Regulation; D005865:Gestational Age; D006801:Humans; D007118:Immunoassay / Q000379:methods; D055432:Metabolomics / Q000379:methods; D051379:Mice; D008928:Mitochondria / Q000378:metabolism; D009436:Neural Tube Defects / Q000175:diagnosis* / Q000378:metabolism*; D011247:Pregnancy; D011270:Pregnancy, Animal; D014805:Vitamin B 12 / Q000378:metabolism
chemical_list: D003993:Dibutyl Phthalate; D005492:Folic Acid; D014805:Vitamin B 12