title: Androgen receptor-driven chromatin looping in prostate cancer.
abstract: The androgen receptor (AR) is important for prostate cancer development and progression. Genome-wide mapping of AR binding sites in prostate cancer has found that the majority of AR binding sites are located within non-promoter regions. These distal AR binding regions regulate AR target genes (e.g. UBE2C) involved in prostate cancer growth through chromatin looping. In addition to long-distance gene regulation, looping has been shown to induce spatial proximity of two genes otherwise located far away along the genomic sequence and the formation of double-strand DNA breaks, resulting in aberrant gene fusions (e.g. TMPRSS2-ERG) that also contribute to prostate tumorigenesis. Elucidating the mechanisms of AR-driven chromatin looping will increase our understanding of prostate carcinogenesis and may lead to the identification of new therapeutic targets.
authors: Department of Molecular and Cellular Biochemistry and the Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH 43210, USA.
authors: Dayong
authors: D
authors: Wu
authors: Chunpeng
authors: C
authors: Zhang
authors: Yanping
authors: Y
authors: Shen
authors: Kenneth P
authors: KP
authors: Nephew
authors: Qianben
authors: Q
authors: Wang
mesh_terms: D000728:Androgens / Q000009:adverse effects / Q000378:metabolism*; D000818:Animals; D002273:Carcinogens / Q000378:metabolism / Q000633:toxicity; D042002:Chromatin Assembly and Disassembly; D050939:Gene Fusion / Q000187:drug effects; D006801:Humans; D008297:Male; D058990:Molecular Targeted Therapy; D050506:Mutant Chimeric Proteins / Q000235:genetics / Q000378:metabolism; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000139:chemically induced / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D011944:Receptors, Androgen / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000728:Androgens; D002273:Carcinogens; D050506:Mutant Chimeric Proteins; D009363:Neoplasm Proteins; D011944:Receptors, Androgen