title: Levels of neutrophil gelatinase-associated lipocalin in 2 patients with crush syndrome after a mudslide.
abstract: Neutrophil gelatinase-associated lipocalin is one of the most promising biomarkers for the diagnosis of acute kidney injury. An increase in the level of neutrophil gelatinase-associated lipocalin is a good predictor of acute kidney injury and is associated with an increase in the serum level of creatinine. Two victims of a mudslide in Messina, Italy, initially had crush syndrome followed by development of acute kidney injury. The development of acute kidney injury is the second most common cause of death after large earthquakes and other natural disasters, but at the same time, crush-related acute kidney injury is one of the few life-threatening complications of crush injuries that can be reversed if diagnosed early and treated. In this case, measuring the level of neutrophil gelatinase-associated lipocalin enabled early diagnosis of acute kidney injury and anticipation of the changes in levels of conventional markers such as creatinine.
authors: Department of Internal Medicine at the University of Messina in Messina, Italy.
authors: Valentina
authors: V
authors: Donato
authors: Alberto
authors: A
authors: Noto
authors: Antonio
authors: A
authors: Lacquaniti
authors: Davide
authors: D
authors: Bolignano
authors: Antonio
authors: A
authors: Versaci
authors: Antonio
authors: A
authors: David
authors: Francesco
authors: F
authors: Spinelli
authors: Michele
authors: M
authors: Buemi
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis / Q000503:physiopathology; D000209:Acute-Phase Proteins; D000328:Adult; D015415:Biomarkers / Q000097:blood; D003444:Crush Syndrome / Q000503:physiopathology*; D005260:Female; D006760:Hospitalization; D006801:Humans; D007558:Italy; D055876:Landslides; D007902:Length of Stay; D000071068:Lipocalin-2; D054834:Lipocalins / Q000097:blood*; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000097:blood*
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins