title: [Ru(bpy)2(5-cyanouracil)2]2+ as a potential light-activated dual-action therapeutic agent.
abstract: The cation cis-[Ru(bpy)(2)(5CNU)(2)](2+) (bpy = 2,2'-bipyridine; 5CNU = 5-cyanouracil) was synthesized and investigated for use as a potential light-activated dual-action therapeutic agent. The complex undergoes efficient photoinduced 5CNU ligand exchange for solvent water molecules, thus simultaneously releasing biologically active 5CNU and generating [Ru(bpy)(2)(H(2)O)(2)](2+). The latter binds covalently to ds-DNA, such that photolysis results in the generation of 3 equiv of potential therapeutic agents from a single molecule.
authors: Department of Chemistry, The Ohio State University, Columbus, Ohio 43210, United States.
authors: Robert N
authors: RN
authors: Garner
authors: Judith C
authors: JC
authors: Gallucci
authors: Kim R
authors: KR
authors: Dunbar
authors: Claudia
authors: C
authors: Turro
mesh_terms: D015082:2,2'-Dipyridyl / Q000737:chemistry; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D056004:Molecular Dynamics Simulation; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D010782:Photolysis; D012428:Ruthenium / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D014498:Uracil / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D056831:Coordination Complexes; D009942:Organometallic Compounds; C056431:5-cyanouracil; D015082:2,2'-Dipyridyl; D014498:Uracil; D012428:Ruthenium; D004247:DNA