title: Could Helicobacter pylori play a role in the aetiopathogenesis of tympanosclerosis?
abstract: OBJECTIVE
  The aetiology of tympanosclerosis is not yet clear. This prospective, controlled, clinical study investigated the relationship between Helicobacter pylori and tympanosclerosis aetiology.
  
  
  METHODS
  The study included 14 patients with tympanosclerosis and 26 with other forms of chronic otitis media. All patients underwent surgery for chronic otitis media. Mucosal biopsies were taken, and examined for H pylori using the Campylobacter-Like Organism (CLO) test.
  
  
  RESULTS
  Tympanoplasty was performed in 29 patients (72.5 per cent), radical mastoidectomy in eight (20 per cent) and myringoplasty in three (7.5 per cent). The presence of H pylori was tested in all tympanosclerosis biopsies, but in only 26.9 per cent of biopsies from other forms of chronic otitis media. A statistically significant difference in H pylori presence was found (p ≤ 0.01).
  
  
  CONCLUSIONS
  This study represents a preliminary investigation of the association between H pylori and tympanosclerosis development.
authors: Third Otorhinolaryngology Clinic, Numune Education and Research Hospital, Ankara, Turkey. ayseiriz@gmail.com
authors: A
authors: A
authors: Iriz
authors: A
authors: A
authors: Eryilmaz
authors: C
authors: C
authors: Gocer
authors: A
authors: A
authors: Acar
authors: S
authors: S
authors: Boynuegri
authors: E
authors: E
authors: Dursun
mesh_terms: D000328:Adult; D001706:Biopsy; D002908:Chronic Disease; D004432:Ear, Middle / Q000382:microbiology* / Q000473:pathology; D005260:Female; D005764:Gastroesophageal Reflux / Q000453:epidemiology; D016481:Helicobacter Infections / Q000150:complications* / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D008416:Mastoid / Q000601:surgery; D009092:Mucous Membrane; D009225:Myringoplasty; D010033:Otitis Media / Q000382:microbiology* / Q000473:pathology / Q000601:surgery; D011446:Prospective Studies; D012598:Sclerosis; D014432:Tympanic Membrane / Q000382:microbiology / Q000473:pathology* / Q000601:surgery; D014433:Tympanoplasty