title: Successful treatment of HTLV-1-related overlap syndrome using tacrolimus.
abstract: A 56-year-old HTLV-I-positive woman, initially diagnosed as having Sjögren's syndrome, presented with muscle weakness, myalgia, face erythema and leg edema. Based on the presence of various autoantibodies, the diagnosis of overlap syndrome (dermatomyositis/Sjögren's syndrome) was made. Treatment with high-dose corticosteroid plus cyclosporine improved her symptoms. However, three months after the start of these treatments, exacerbation of myositis occurred. A muscle biopsy revealed prominent perivascular accumulation of mononuclear cells with perifascicular atrophy, which were consistent with dermatomyositis. Tacrolimus, which was substituted for cyclosporine led to marked improvement of the myositis symptoms.
authors: Department of General Internal Medicine and Rheumatology, NHO National Nagasaki Medical Center, Japan. yizumi@nmc.hosp.go.jp
authors: Yasumori
authors: Y
authors: Izumi
authors: Hiroshi
authors: H
authors: Kojima
authors: Yasushi
authors: Y
authors: Koga
authors: Kazuaki
authors: K
authors: Yokota
authors: Hideki
authors: H
authors: Mori
authors: Tadayoshi
authors: T
authors: Ohno
authors: Taiichiro
authors: T
authors: Miyashita
authors: Masahiro
authors: M
authors: Ito
authors: Masakatsu
authors: M
authors: Motomura
authors: Masanobu
authors: M
authors: Mine
authors: Hironori
authors: H
authors: Ezaki
authors: Yuka
authors: Y
authors: Jiuchi
authors: Daisuke
authors: D
authors: Niino
authors: Kouichi
authors: K
authors: Ohshima
authors: Kiyoshi
authors: K
authors: Migita
mesh_terms: D003882:Dermatomyositis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D015490:HTLV-I Infections / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D015368:Human T-lymphotropic virus 1 / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D016559:Tacrolimus / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D016559:Tacrolimus