title: Cleavable linkers in chemical biology.
abstract: Interest in cleavable linkers is growing due to the rapid development and expansion of chemical biology. The chemical constrains imposed by the biological conditions cause significant challenges for organic chemists. In this review we will present an overview of the cleavable linkers used in chemical biology classified according to their cleavage conditions by enzymes, nucleophilic/basic reagents, reducing agents, photo-irradiation, electrophilic/acidic reagents, organometallic and metal reagents, oxidizing reagents.
authors: Laboratory of Functional Chemo-Systems UMR 7199, 74 Route du Rhin, 67401 Illkirch-Graffenstaden, France.
authors: Geoffray
authors: G
authors: Leriche
authors: Louise
authors: L
authors: Chisholm
authors: Alain
authors: A
authors: Wagner
mesh_terms: D003432:Cross-Linking Reagents / Q000737:chemistry*; D004798:Enzymes / Q000378:metabolism; D008670:Metals / Q000737:chemistry; D016877:Oxidants / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000737:chemistry; D055668:Photochemical Processes; D040901:Proteomics; D019163:Reducing Agents / Q000737:chemistry
chemical_list: D003432:Cross-Linking Reagents; D004798:Enzymes; D008670:Metals; D016877:Oxidants; D004364:Pharmaceutical Preparations; D019163:Reducing Agents