title: PLP-dependent enzymes as potential drug targets for protozoan diseases.
abstract: The chemical properties of the B(6) vitamers are uniquely suited for wide use as cofactors in essential reactions, such as decarboxylations and transaminations. This review addresses current efforts to explore vitamin B(6) dependent enzymatic reactions as drug targets. Several current targets are described that are found amongst these enzymes. The focus is set on diseases caused by protozoan parasites. Comparison across a range of these organisms allows insight into the distribution of potential targets, many of which may be of interest in the development of broad range anti-protozoan drugs. This article is part of a Special Issue entitled: Pyridoxal Phosphate Enzymology.
authors: University Hospital Heidelberg, Department of Infectious Diseases, Parasitology, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany.
authors: Barbara
authors: B
authors: Kappes
authors: Ivo
authors: I
authors: Tews
authors: Alexandra
authors: A
authors: Binter
authors: Peter
authors: P
authors: Macheroux
mesh_terms: D000818:Animals; D001219:Aspartate Aminotransferases / Q000187:drug effects / Q000378:metabolism; D013437:Carbon-Sulfur Lyases / Q000187:drug effects / Q000378:metabolism; D003547:Cysteine Synthase / Q000187:drug effects / Q000378:metabolism; D004798:Enzymes / Q000378:metabolism*; D012696:Glycine Hydroxymethyltransferase / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D006867:Hydrolases / Q000187:drug effects / Q000378:metabolism; D009955:Ornithine Decarboxylase / Q000187:drug effects / Q000378:metabolism; D011528:Protozoan Infections / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism; D011732:Pyridoxal Phosphate / Q000378:metabolism*; D014349:Trypanosoma cruzi / Q000201:enzymology
chemical_list: D004798:Enzymes; D011732:Pyridoxal Phosphate; D012696:Glycine Hydroxymethyltransferase; D003547:Cysteine Synthase; D001219:Aspartate Aminotransferases; D006867:Hydrolases; C021480:kynureninase; D009955:Ornithine Decarboxylase; D013437:Carbon-Sulfur Lyases; C080546:cysteine desulfurase; C021558:L-methionine gamma-lyase