title: DePICTing p53 activation: a new nucleolar link to cancer.
abstract: p53 activation by ribosomal biogenesis stress is important for tumor suppression. In the August issue of Nature Medicine, Sasaki et al. identify PICT1 as a regulator of this process. PICT1 sequesters ribosomal protein RPL11 in the nucleolus, attenuating p53 induction. Excessive PICT1 may dampen the p53 response and promote cancer.
authors: Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel.
authors: Lior
authors: L
authors: Golomb
authors: Moshe
authors: M
authors: Oren