title: Changes in serum obestatin, preptin and ghrelins in patients with Gestational Diabetes Mellitus.
abstract: OBJECTIVE
  The present study aims to establish the levels of acylated ghrelin, desacylated ghrelin, obestatin and preptin, during pregnancy and the postpartum period in pregnant women with Gestational Diabetes Mellitus (GDM) and healthy pregnancy women.
  
  
  METHODS
  The study registered 20 pregnant women with GDM and 20 healthy pregnant women. Fasting venous blood samples were collected from all cases between weeks 24 and 28 of pregnancy and after 24h postpartum. Hormones were analyzed using ELISA method.
  
  
  RESULTS
  Serum acylated ghrelin (p:0.001), desacylated ghrelin (p:0.001), obestatin (p:0.006) and preptin (p:0.001) levels were all found statistically higher in both groups during the postpartum period, when compared to the pregnancy period. A positive correlation was established between desacylated ghrelin and acylated ghrelin (p:0.008), desacylated ghrelin and preptin (p:0.012) and preptin and insulin (p:0.039) in the GDM group during pregnancy.
  
  
  CONCLUSIONS
  The studied hormones (especially desacylated ghrelin and obestatin) are critical in GDM pathophysiology based on the comparison of measure after and before the delivery.
authors: Department of Obstetrics and Gynecology, Firat University Hospital, Elazig, Turkey.
authors: Yakup
authors: Y
authors: Baykus
authors: Bilgin
authors: B
authors: Gurates
authors: Suleyman
authors: S
authors: Aydin
authors: Husnu
authors: H
authors: Celik
authors: Burcin
authors: B
authors: Kavak
authors: Aziz
authors: A
authors: Aksoy
authors: Ibrahim
authors: I
authors: Sahin
authors: Rulin
authors: R
authors: Deniz
authors: Sami
authors: S
authors: Gungor
authors: Saadet P
authors: SP
authors: Guzel
authors: Yagmur
authors: Y
authors: Minareci
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003710:Demography; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D007335:Insulin-Like Growth Factor II; D010446:Peptide Fragments / Q000097:blood*; D011247:Pregnancy
chemical_list: D054439:Ghrelin; D010446:Peptide Fragments; C422650:ghrelin, des-n-octanoyl; C443100:preptin; D007335:Insulin-Like Growth Factor II