title: Multiple eruptive clear cell acanthoma.
abstract: BACKGROUND
  Clear cell acanthoma is a rare solitary benign epidermal tumor of unknown etiology. The disease arises in the middle-age, with no sex predominance. It appears as a single reddish papule or papule-nodule and a peripheral scaling collarette is characteristic. Although solitary lesions are the rule, less than 30 cases of multiple Clear cell acanthoma have been described in the literature to date.
  
  
  METHODS
  We report an unusual case of a healthy 74-year-old male with multiple clear cell acanthoma on the lower extremities treated successfully with cryotherapy.
  
  
  CONCLUSIONS
  Despite significant progress in treatment of clear cell acanthoma, cryotherapy, based on liquid nitrogen, remains an important alternative in treating multiple clear cell acanthomas.
authors: Department of Dermatology, University of Brescia, Brescia, Italy.
authors: Paola
authors: P
authors: Monari
authors: Camillo
authors: C
authors: Farisoglio
authors: Giulio
authors: G
authors: Gualdi
authors: Giorgio
authors: G
authors: Botali
authors: Marco
authors: M
authors: Ungari
authors: Piergiacomo
authors: P
authors: Calzavara-Pinton