title: Fetal risks of maternal pharmacotherapy: identifying signals.
abstract: Pregnant women may be exposed to a variety of medications that may exert toxic or teratogenic effects on the fetus. Since the thalidomide disaster, physicians and pregnant women tend to withhold medications during pregnancy, although the risk of teratogenic effect from most drugs in therapeutic doses is nonexistent. This chapter will review the principles of teratology and the pharmacoepidemiological evidence for drug safety/risk in human gestation.
authors: The Motherisk Program, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto M5G 1X8, ON, Canada. gidiup_2000@yahoo.com
authors: Gideon
authors: G
authors: Koren
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000453:epidemiology*; D000028:Abortion, Induced; D015982:Bias; D016022:Case-Control Studies; D015986:Confounding Factors, Epidemiologic; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D005333:Fetus / Q000002:abnormalities / Q000187:drug effects; D006801:Humans; D008019:Life Style; D017891:Pharmacoepidemiology; D011247:Pregnancy; D011264:Pregnancy Trimesters; D011446:Prospective Studies; D012189:Retrospective Studies; D012306:Risk; D018401:Sample Size; D013723:Teratogens / Q000494:pharmacology; D018600:Teratology; D013997:Time Factors
chemical_list: D013723:Teratogens