title: Advances in the understanding of the structure and function of ER-α36,a novel variant of human estrogen receptor-alpha.
abstract: Estrogen receptors (ERs) belong to the nuclear receptor superfamily, whose members include ER-α66, ER-α36, ER-α46 and ER-β. Each receptor performs specific functions through binding with a specific ligand, such as estrogen. Recently, ER-α36, a novel variant of human estrogen receptor-alpha (ER-α), was identified and cloned. ER-α36 inhibits, in a dominant-negative manner, the transactivation of both the wild-type ER-α (ER-α66) and ER-β. As a predominantly membrane-based ER, ER-α36 mediates nongenomic estrogen signaling and is involved in the resistance of breast cancer to endocrine therapy, i.e., tamoxifen. This review summarizes recent studies on the structure and function of ER-α36 and the relationship of ER-α36 with cancer, with special emphasis on its function in the resistance of breast cancer to endocrine therapy.
authors: Department of Biochemistry and Molecular Biology, Third Military Medical University, Chongqing 400038, China.
authors: Jun
authors: J
authors: Rao
authors: Xiaomei
authors: X
authors: Jiang
authors: Yang
authors: Y
authors: Wang
authors: Bin
authors: B
authors: Chen
mesh_terms: D000595:Amino Acid Sequence; D001943:Breast Neoplasms / Q000378:metabolism; D047628:Estrogen Receptor alpha / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D004967:Estrogens / Q000378:metabolism; D005260:Female; D006801:Humans; D008969:Molecular Sequence Data; D015398:Signal Transduction; D013329:Structure-Activity Relationship
chemical_list: C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D004967:Estrogens