title: Estrogen carcinogenesis in breast cancer.
abstract: Many studies have reported a correlation between elevated estrogen blood levels and breast cancer and this observation has raised controversy concerning the long-term use of hormonal replacement therapy. This review will not address further this controversial topic; but rather, this review focuses on the role of estrogen signaling in first, the normal development of the breast and second, how alterations of this signaling pathway contribute to breast cancer.
authors: Division of Hematology/Oncology, Department of Medicine, Tisch Cancer Insitute, Mount Sinai School of Medicine, One New York, NY 10029, USA. doris.germain@mssm.edu
authors: Doris
authors: D
authors: Germain
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D002277:Carcinoma / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D004967:Estrogens / Q000009:adverse effects / Q000378:metabolism / Q000502:physiology*; D005260:Female; D006801:Humans; D051379:Mice; D009376:Neoplasms, Hormone-Dependent / Q000209:etiology / Q000235:genetics; D011960:Receptors, Estrogen / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology
chemical_list: D004967:Estrogens; D011960:Receptors, Estrogen