title: MicroRNA-146a and hemopoietic disorders.
abstract: MicroRNAs (MiRNAs) are a class of small non-coding regulatory RNAs that repress protein expression at the posttranscriptional level and play important roles in hematopoiesis processes. MiR-146a is a miRNA that is thought to regulate physiological and pathophysiological pathways in hematopoietic cells. In this review, we focus on recent progress in analyzing the functional roles of miR-146a in normal hematopoiesis and hematopoietic disease. We suggest that manipulation of miR-146a expression may represent a potential new therapy for several hematopoietic diseases, and may further serve as a biomarker for diagnosis, prevention, and treatment of such disease.
authors: Department of Hematology, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, 200127, People's Republic of China.
authors: Zhong
authors: Z
authors: Hua
authors: Department of Hematology, Shanghai First People's Hospital, Shanghai Jiaotong University, Shanghai, 200080, People's Republic of China. wangchunMD@163.com.
authors: Wang
authors: W
authors: Chun
authors: Department of Hematology, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, 200127, People's Republic of China.
authors: Chen
authors: C
authors: Fang-Yuan
mesh_terms: D005786:Gene Expression Regulation; D016147:Genes, Tumor Suppressor; D006402:Hematologic Diseases / Q000235:genetics* / Q000378:metabolism; D019337:Hematologic Neoplasms / Q000235:genetics / Q000378:metabolism; D006410:Hematopoiesis / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009857:Oncogenes
chemical_list: C542542:MIRN146 microRNA, human; D035683:MicroRNAs