title: Serum screening for detection of high-risk group for early-stage diffuse type gastric cancer in Japanese.
abstract: OBJECTIVE
  Serum screening systems are beneficial for gastric cancer mass surveys; however, the marker for diffuse type gastric cancer (DGC) is not defined. We attempted to define the high-risk group for DGC by using serum markers of anti-Helicobacter pylori antibody and pepsinogens (PG).
  
  
  METHODS
  Forty-two patients in the early stage of DGC and 511 controls were enrolled. Fasting serum samples were collected, and anti-H. pylori antibody and PG were evaluated. The risk for DGC was calculated.
  
  
  RESULTS
  The prevalence of DGC was higher in H. pylori-positive patients (odds ratio [OR] = 4.3 in men, 9.6 in women). DGC prevalence was significantly higher in the PG1+ group in women (OR = 10.7); however, it was lower in the PG3+ group in both men and women. Patients with PG II ≥ 30 revealed a significantly higher risk for DGC. By combining factors, higher OR (OR = 12.5 in men, 42.7 in women) were obtained when we defined the risk group as H. pylori-positive, PG-negative, and having PG II ≥ 30.
  
  
  CONCLUSIONS
  The risk group for DGC can be defined by evaluating ordinary serum gastritis markers.
authors: Department of Gastroenterology and Metabolism, Hiroshima University, Hiroshima, Japan. maito@hiroshima-u.ac.jp
authors: Masanori
authors: M
authors: Ito
authors: Masaharu
authors: M
authors: Yoshihara
authors: Shunsuke
authors: S
authors: Takata
authors: Yoshihiro
authors: Y
authors: Wada
authors: Taiji
authors: T
authors: Matsuo
authors: Tomoyuki
authors: T
authors: Boda
authors: Shinji
authors: S
authors: Tanaka
authors: Kazuaki
authors: K
authors: Chayama
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D016481:Helicobacter Infections / Q000276:immunology*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020115:Pepsinogen C / Q000097:blood*; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000097:blood* / Q000175:diagnosis
chemical_list: D000907:Antibodies, Bacterial; D014408:Biomarkers, Tumor; D020115:Pepsinogen C