title: Systems biology: confronting the complexity of cancer.
abstract: The AACR-NCI Conference "Systems Biology: Confronting the Complexity of Cancer" took place from February 27 to March 2, 2011, in San Diego, CA. Several themes resonated during the meeting, notably (i) the need for better methods to distill insights from large-scale networks, (ii) the importance of integrating multiple data types in constructing more realistic models, (iii) challenges in translating insights about tumorigenic mechanisms into therapeutic interventions, and (iv) the role of the tumor microenvironment, at the physical, cellular, and molecular levels. The meeting highlighted concrete applications of systems biology to cancer, and the value of collaboration between interdisciplinary researchers in attacking formidable problems.
authors: Center for Cancer Systems Biology and Department of Radiology, School of Medicine, Stanford University, Stanford, California, USA. andrewg@stanford.edu
authors: Andrew J
authors: AJ
authors: Gentles
authors: Daniel
authors: D
authors: Gallahan
mesh_terms: D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D049490:Systems Biology / Q000379:methods*; D059016:Tumor Microenvironment