title: Antiviral activity of Distictella elongata (Vahl) Urb. (Bignoniaceae), a potentially useful source of anti-dengue drugs from the state of Minas Gerais, Brazil.
abstract: OBJECTIVE
  To investigate the in vitro antiviral activity of Distictella elongata (Vahl) Urb. ethanol extracts from leaves (LEE), fruits (FEE), stems and their main components.
  
  
  RESULTS
  The antiviral activity was evaluated against human herpesvirus type 1 (HSV-1), murine encephalomyocarditis virus (EMCV), vaccinia virus Western Reserve (VACV-WR) and dengue virus 2 (DENV-2) by the 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric assay. LEE presented anti-HSV-1 [EC(50) 142.8 ± 5.3 μg ml(-1); selectivity index (SI) 2.0] and anti-DENV-2 activity (EC(50) 9.8 ± 1.3 μg ml(-1) ; SI 1.5). The pectolinarin (1) isolated from LEE was less active against HSV-1 and DENV-2. A mixture of the triterpenoids ursolic, pomolic and oleanolic acids was also obtained. Ursolic and oleanolic acids have shown antiviral activity against HSV-1. A mixture of pectolinarin (1) and acacetin-7-O-rutinoside (2) was isolated from FEE and has presented anti-DENV-2 activity (EC(50) 11.1 ± 1.6 μg ml(-1) ; SI > 45). Besides the antiviral activity, D. elongata has disclosed antioxidant effect.
  
  
  CONCLUSIONS
  These data shows that D. elongata has antiviral activity mainly against HSV-1 and DENV-2, besides antioxidant activity. These effects might be principally attributed to flavonoids isolated.
  
  
  CONCLUSIONS
  Distictella elongata might be considered a promising source of anti-dengue fever phytochemicals.
authors: Faculty of Pharmacy, Department of Pharmaceutical Products, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors: L R
authors: LR
authors: Simões
authors: G M
authors: GM
authors: Maciel
authors: G C
authors: GC
authors: Brandão
authors: E G
authors: EG
authors: Kroon
authors: R O
authors: RO
authors: Castilho
authors: A B
authors: AB
authors: Oliveira
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D029402:Bignoniaceae / Q000737:chemistry*; D001938:Brazil; D003715:Dengue / Q000188:drug therapy; D003716:Dengue Virus / Q000187:drug effects*; D006801:Humans; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D014780:Viruses / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D010936:Plant Extracts