title: Laryngeal and respiratory patterns in patients with paradoxical vocal fold motion.
abstract: The purposes of this study were to determine the differences in spirometric measures obtained from patients with endoscopically-documented paradoxical vocal fold motion (PVFM) and to compare them to a group of normal subjects without endoscopically-documented paradoxical vocal fold motion during non-provocative breathing and following speech. Thirty eight subjects with documented paradoxical vocal fold motion using transnasal flexible laryngoscopy (TFL) and no history of asthma and 21 normal subjects with documented normal breathing patterns and normal findings on endoscopy underwent flow-volume loop studies. Endoscopic judgments of vocal fold motion from three breathing conditions were made by two observers. The results of the endoscopic judgments indicate that paradoxical motion occurs whether breathing through the nose or mouth in the PVFM subjects, mainly after speaking and inhalation. In addition, the spirometry results indicated that the inspiratory measure of FIVC%, FVC% and FIV(0.5)/FIVC were significantly lower in the PVFM group compared to the normal subjects. The data supports the hypothesis that in patients with PVFM, inspiratory spirometric values play a role in identifying patients with PVFM. The finding of vocal fold closure following a speech utterance in the majority of the PVFM subjects but not in the normal control group warrants further investigation.
authors: Department of Otolaryngology-Head and Neck Surgery, Weill Cornell Medical College, New York, NY 1002, USA. thm7001@med.cornell.edu
authors: Thomas
authors: T
authors: Murry
authors: Sabrina
authors: S
authors: Cukier-Blaj
authors: Alison
authors: A
authors: Kelleher
authors: Khalid H
authors: KH
authors: Malki
mesh_terms: D000328:Adult; D000368:Aged; D001945:Breathing Exercises; D005260:Female; D006801:Humans; D007818:Laryngeal Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D007828:Laryngoscopy; D008297:Male; D008875:Middle Aged; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D012189:Retrospective Studies; D013060:Speech; D013065:Speech Intelligibility; D016896:Treatment Outcome; D014827:Vocal Cords / Q000002:abnormalities / Q000503:physiopathology*
chemical_list: D054328:Proton Pump Inhibitors