title: The Zn(2+) complex of 1,4,7,10-tetraazacyclododecane as an artificial nucleobase.
abstract: {2-Deoxy-3-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5-O-(4,4'-dimethoxytrityl)-α-D- erythro-pentofuranosyl}-N-{2-[4,7,10-tris(2,2,2-trifluoroacetyl)-1,4,7,10-tetraazacyclododecan-1- yl]ethyl}acetamide (1) was prepared and incorporated into a 2'-O-methyl oligoribonucleotide. The hybridization of this oligonucleotide with complementary 2'-O-methyl oligoribonucleotides incorporating one to five uracil bases opposite to the azacrown structure was studied in the absence and presence of Zn(2+). Introduction of Zn(2+) moderately stabilized the duplex with U-bulged targets.
authors: Department of Chemistry, University of Turku, Turku, Finland.
authors: Maarit
authors: M
authors: Laine
authors: Maria
authors: M
authors: Aromaa
authors: Pasi
authors: P
authors: Virta
authors: Tuomas
authors: T
authors: Lönnberg
authors: Päivi
authors: P
authors: Poijärvi-Virta
authors: Harri
authors: H
authors: Lönnberg
mesh_terms: D056831:Coordination Complexes / Q000737:chemistry*; D000080027:Cyclams; D006571:Heterocyclic Compounds / Q000737:chemistry*; D009843:Oligoribonucleotides / Q000737:chemistry*; D014498:Uracil / Q000737:chemistry; D015032:Zinc / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D000080027:Cyclams; D006571:Heterocyclic Compounds; D009843:Oligoribonucleotides; D014498:Uracil; C038072:cyclen; D015032:Zinc