title: Relationship between the structures of flavonoids and their NF-κB-dependent transcriptional activities.
abstract: It has been previously shown that some flavonoids inhibit NF-κB; however, the structure-activity relationships between chalcone, flavanone, flavone, and isoflavone derivatives and their TNFα induced NF-κB inhibitory effects on HCT116 human colon cancer cells have not yet been reported. Therefore, in this study, the effects of flavonoid structure on inhibition of NF-κB were investigated. Based on the combined results of this study, the structure of the flavonoids was shown to affect NF-κB activation.
authors: Department of Biomedical Science and Technology, SMART-Institute of Advanced Biomedical Science, RCTC, Konkuk University, Seoul 143-701, Republic of Korea.
authors: Soon Young
authors: SY
authors: Shin
authors: Yoonkyung
authors: Y
authors: Woo
authors: Jiye
authors: J
authors: Hyun
authors: Yeonjoong
authors: Y
authors: Yong
authors: Dongsoo
authors: D
authors: Koh
authors: Young Han
authors: YH
authors: Lee
authors: Yoongho
authors: Y
authors: Lim
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000188:drug therapy; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008958:Models, Molecular; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000276:immunology; D013329:Structure-Activity Relationship; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D005419:Flavonoids; D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha