title: Is joint hypermobility associated with vesico-ureteral reflux? An assessment of 50 patients.
abstract: OBJECTIVE
  To assess whether there is an increased prevalence of joint hypermobility in patients with vesico-ureteric reflux (VUR).
  
  
  METHODS
  We studied 50 patients with primary VUR and matched controls drawn from a reference population. Joint mobility was assessed using the Bulbena hypermobility score.
  
  
  RESULTS
  We identified significantly more patients with VUR with generalized joint hypermobility than controls (24% vs 6.7%, P= 0.007).
  
  
  CONCLUSIONS
  Our findings confirm our clinical observation of an increased rate of joint hypermobility in patients with VUR. We speculate that an altered composition of the connective tissue may contribute to the severity of the (pre-existing) VUR phenotype.
authors: Departments of Medical Genetics, University Medical Centre Utrecht, The Netherlands. a.vaneerde@umcutrecht.nl
authors: Albertien M
authors: AM
authors: van Eerde
authors: Virginie J M
authors: VJ
authors: Verhoeven
authors: Tom P V M
authors: TP
authors: de Jong
authors: Elise M
authors: EM
authors: van de Putte
authors: Jacques C
authors: JC
authors: Giltay
authors: Raoul H H
authors: RH
authors: Engelbert
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D015994:Incidence; D007593:Joint Instability / Q000150:complications* / Q000453:epidemiology; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D015995:Prevalence; D012372:ROC Curve; D018570:Risk Assessment; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014718:Vesico-Ureteral Reflux / Q000453:epidemiology / Q000209:etiology*