title: [Application of coenzyme Q(10) in combination therapy of arterial hypertension].
abstract: We studied effect of coenzyme Q(10) on 24-hour blood pressure profile and function of vascular endothelium in patients with essential hypertension. Coenzyme Q(10) was used as a component of combination therapy comprising angiotensin converting enzyme inhibitor enalapril. Administration of coenzyme Q(10) in combination with traditional antihypertensive therapy promoted normalization of vascular endothelial function and more effective correction of 24-hour blood pressure profile. These findings allow to consider the use of coenzyme Q(10) as promising component of combination therapy of arterial hypertension.
authors: V P
authors: VP
authors: Mikhin
authors: A V
authors: AV
authors: Kharchenko
authors: E A
authors: EA
authors: Rosliakova
authors: M A
authors: MA
authors: Cherniatina
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage; D001794:Blood Pressure / Q000187:drug effects*; D016903:Drug Monitoring; D004359:Drug Therapy, Combination; D004656:Enalapril / Q000008:administration & dosage*; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism; D045462:Endothelium-Dependent Relaxing Factors / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D016896:Treatment Outcome; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014664:Vasodilation / Q000187:drug effects*; D014815:Vitamins
chemical_list: D000959:Antihypertensive Agents; D045462:Endothelium-Dependent Relaxing Factors; D014815:Vitamins; D014451:Ubiquinone; D004656:Enalapril; C024989:coenzyme Q10