title: High levels of circulating CD34+ cells at autologous stem cell collection are associated with favourable prognosis in multiple myeloma.
abstract: BACKGROUND
  High-dose chemotherapy with autologous stem cell transplantation is a cornerstone in the first-line treatment of multiple myeloma patients. However, only few factors have been identified affecting the outcome in such patients. We hypothesised that varying levels of mobilised CD34+ cells confer prognostic information in myeloma patients undergoing high-dose chemotherapy.
  
  
  METHODS
  We determined circulating CD34+ cells at the day of peripheral stem cell collection in 158 consecutive myeloma patients between January 2001 and August 2010. Patients were stratified into two groups (super vs normal mobilisers) with a cutoff of 100,000 peripheral CD34+ cells per ml.
  
  
  RESULTS
  We found that patients with more than 100,000 peripheral CD34+ cells per ml had a better overall survival (P=0.005) and a prolonged time to progression (P=0.0398) than patients with CD34+ cell counts below 100,000 CD34+ cells per ml. High levels of CD34+ cells were an independent marker for better overall survival and time to progression in a multivariate analysis that included disease stage, response at transplant, light-chain subtype, age, sex, and height.
  
  
  CONCLUSIONS
  Our results suggest that high levels of mobilised peripheral CD34+ cells are associated with favourable outcome in myeloma patients undergoing autologous transplantation.
authors: Department of Medical Oncology, University Hospital and University of Berne, Berne, Switzerland.
authors: J
authors: J
authors: Raschle
authors: D
authors: D
authors: Ratschiller
authors: S
authors: S
authors: Mans
authors: B U
authors: BU
authors: Mueller
authors: T
authors: T
authors: Pabst
mesh_terms: D000328:Adult; D018952:Antigens, CD34 / Q000097:blood*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood* / Q000401:mortality / Q000628:therapy*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D014182:Transplantation, Autologous
chemical_list: D018952:Antigens, CD34