title: [The clinical significance of S100β protein in cerebrospinal fluid and serum from the patients with cerebral hemorrhage].
abstract: OBJECTIVE
  To observe the change and the clinical significance of S100β protein level in cerebrospinal fluid and serum from the patients with cerebral hemorrhage (CH).
  
  
  METHODS
  ELISA was used to detect the expression of S100β protein in CSF and serum from CH patients control with Inguinal Hernia or great saphenous varix patients. Meanwhile, rabbit CH model at 6 h, 12 h, 24 h, 48 h, 72 h and 96 h .
  
  
  RESULTS
  The levels of CSF S100β protein at acute stage of CH patients increased significantly compared with those at recovery stage of CH patients and control group(P<0.01). The levels of S100β protein in CSF from CH patients increased significantly compared with those in serum (P<0.01).The levels of S100β protein in CSF of rabbit experimental group increased significantly compared with those of sham operation group at different time points(P<0.01).
  
  
  CONCLUSIONS
  The level of S100β protein in CSF from CH patients increases. It may be a biomarker as reflecting degree of pathogenetic and predicting outcome in the CH patients.
authors: Department of Pathogenic Organism and Immunology, Medical College, Northwest University for Nationalities, Lanzhou 730030, China.
authors: Li
authors: L
authors: Sheng
authors: Li-Feng
authors: LF
authors: An
authors: Sheng-Xiang
authors: SX
authors: Wu
authors: Yi-Long
authors: YL
authors: Yin
authors: You-Jun
authors: YJ
authors: Mi
authors: Cai-Hong
authors: CH
authors: Ci
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D002543:Cerebral Hemorrhage / Q000175:diagnosis*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood* / Q000134:cerebrospinal fluid*; D011379:Prognosis; D011817:Rabbits; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood* / Q000134:cerebrospinal fluid*; D013997:Time Factors
chemical_list: D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins