title: Dissection of human MiRNA regulatory influence to subpathway.
abstract: The global insight into the relationships between miRNAs and their regulatory influences remains poorly understood. And most of complex diseases may be attributed to certain local areas of pathway (subpathway) instead of the entire pathway. Here, we reviewed the studies on miRNA regulations to pathways and constructed a bipartite miRNAs and subpathways network for systematic analyzing the miRNA regulatory influences to subpathways. We found that a small fraction of miRNAs were global regulators, environmental information processing pathways were preferentially regulated by miRNAs, and miRNAs had synergistic effect on regulating group of subpathways with similar function. Integrating the disease states of miRNAs, we also found that disease miRNAs regulated more subpathways than nondisease miRNAs, and for all miRNAs, the number of regulated subpathways was not in proportion to the number of the related diseases. Therefore, the study not only provided a global view on the relationships among disease, miRNA and subpathway, but also uncovered the function aspects of miRNA regulations and potential pathogenesis of complex diseases. A web server to query, visualize and download for all the data can be freely accessed at http://bioinfo.hrbmu.edu.cn/miR2Subpath.
authors: College of Bioinformatics Science and Technology and Bio-pharmaceutical Key Laboratory of Heilongjiang Province, Harbin Medical University, Harbin 150081, P. R. China. lixia@hrbmu.edu.cn
authors: Xia
authors: X
authors: Li
authors: Wei
authors: W
authors: Jiang
authors: Wei
authors: W
authors: Li
authors: Baofeng
authors: B
authors: Lian
authors: Shuyuan
authors: S
authors: Wang
authors: Mingzhi
authors: M
authors: Liao
authors: Xiaowen
authors: X
authors: Chen
authors: Yanqiu
authors: Y
authors: Wang
authors: Yingli
authors: Y
authors: Lv
authors: Shiyuan
authors: S
authors: Wang
authors: Lei
authors: L
authors: Yang
mesh_terms: D000465:Algorithms; D030541:Databases, Genetic; D053263:Gene Regulatory Networks; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics
chemical_list: D035683:MicroRNAs; D014157:Transcription Factors