title: Protection of selenium on hepatic mitochondrial respiratory control ratio and respiratory chain complex activities in ducklings intoxicated with aflatoxin B₁.
abstract: To investigate the protection of selenium on hepatic mitochondrial functions, 90 7-day-old ducklings were randomly divided into three groups (groups I-III). Group I was used as a blank control. Group II was administered with aflatoxin B(1) (0.1 mg/kg body weight). Group III was administered with aflatoxin B(1) (0.1 mg/kg body weight) plus selenium (sodium selenite, 1 mg/kg body weight). All treatments were given once daily for 21 days. The results showed that the activities of hepatic mitochondrial complexes I-IV in group II ducklings significantly decreased when compared with group I (P < 0.01). Furthermore, the activities of hepatic mitochondrial complexes I-IV in group III significantly increased when compared with group II (P < 0.05). The hepatic mitochondrial respiratory control ratio (RCR) in group II ducklings significantly decreased when compared with group I (P < 0.01). In addition, the hepatic mitochondrial RCR in group III significantly increased when compared with group II (P < 0.05). These results revealed that the aflatoxin B(1) significantly induced hepatic mitochondrial dysfunction in the activities of hepatic mitochondrial respiratory chain complexes I-IV and the RCR in ducklings. However, sodium selenite could significantly ameliorate the negative effect induced by aflatoxin B(1).
authors: College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
authors: Dayou
authors: D
authors: Shi
authors: Shining
authors: S
authors: Guo
authors: Shenquan
authors: S
authors: Liao
authors: Rongsheng
authors: R
authors: Su
authors: Mingsheng
authors: M
authors: Guo
authors: Nian
authors: N
authors: Liu
authors: Pengfei
authors: P
authors: Li
authors: Zhaoxin
authors: Z
authors: Tang
mesh_terms: D016604:Aflatoxin B1 / Q000506:poisoning* / Q000633:toxicity; D000818:Animals; D004372:Ducks; D004579:Electron Transport; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D010101:Oxygen Consumption; D012119:Respiration / Q000187:drug effects*; D012643:Selenium / Q000494:pharmacology*
chemical_list: D016604:Aflatoxin B1; D012643:Selenium