title: The role of common variants of the cholesteryl ester transfer protein gene in left main coronary artery disease.
abstract: BACKGROUND
  The cholesteryl ester transfer protein (CETP) has a central role in the lipid metabolism and therefore may alter the susceptibility to atherosclerosis.
  
  
  METHODS
  The DNA of 471 subjects [133 subjects with angiographically documented left main coronary artery disease (LMCAD), 241 subjects with more peripheral coronary artery disease (MPCAD) and 97 subjects self reported healthy (Controls)] was analyzed for the frequency of TaqIB and I405V polymorphisms in the gene coding CETP.
  
  
  RESULTS
  There is no significant difference in CETP allele frequency or genotype distribution among LMCAD and MPCAD patients although there is statistical difference between LMCAD and Controls (p = 0.001). Specifically, patients with LMCAD and B1B1 genotype of TaqIB polymorphism were more frequent present compared to Controls (33.8% vs 22.9%, respectively). The frequency of B2B2 genotype was 3 times lower in the LMCAD group compared to Controls (10.5% vs 30.2%, respectively). In the LMCAD group the frequency of B1 allele compared to Controls was higher (62% vs 46%, respectively, p = 0.001). The relationship between TaqIB gene polymorphism and the LMCAD was independent of lipid profile, with the exception of apolipoprotein A.
  
  
  CONCLUSIONS
  These findings indicate that the TaqIB polymorphism may have potential importance in screening individuals at high risk for developing CAD. However, this polymorphism cannot distinguish between LMCAD and MPCAD. Further prospective investigations in larger populations are required to confirm these findings.
authors: 1st Cardiology Department, Onassis Cardiac Surgery Center 356, Sygrou Ave,, 176 74 Athens, Greece. genovefa@kolovou.com
authors: Genovefa
authors: G
authors: Kolovou
authors: Ioannis
authors: I
authors: Vasiliadis
authors: Vana
authors: V
authors: Kolovou
authors: Agathi
authors: A
authors: Karakosta
authors: Sophie
authors: S
authors: Mavrogeni
authors: Evaggelia
authors: E
authors: Papadopoulou
authors: Spiridon
authors: S
authors: Papamentzelopoulos
authors: Vasiliki
authors: V
authors: Giannakopoulou
authors: Apostolia
authors: A
authors: Marvaki
authors: Dimitrios
authors: D
authors: Degiannis
authors: Helen
authors: H
authors: Bilianou
mesh_terms: D000368:Aged; D000483:Alleles; D019943:Amino Acid Substitution; D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D003331:Coronary Vessels / Q000473:pathology*; D005091:Exons; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D006115:Greece; D006801:Humans; D007438:Introns; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
chemical_list: C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D008055:Lipids