title: Locally invasive lymphangiosarcoma in a young domestic shorthair.
abstract: A 2-year-old, female spayed, domestic shorthair cat presented to the University of Missouri-Veterinary Medical Teaching Hospital (UMC-VMTH) with an approximately 11-month history of fluid-draining pockets along her ventral thorax and axillae. The skin in these regions was erythematous, and multiple areas drained a serous to serosanguinous fluid. Fluid-filled, nodules formed along the ventrum, but these nodules disappeared as fluid drained spontaneously. Histologic assessment of skin biopsies revealed areas of vascular proliferation extending along the deep margin of the section and rare instances of invasion into the superficial dermis. These vascular channels were devoid of cells, lined by variably pleomorphic endothelial cells which had a low mitotic index. Based on the mild to moderate pleomorphism, positive staining with prospero-related homeobox gene-1 (PROX-1), and the locally aggressive nature of the tumor, a final diagnosis of lymphangiosarcoma was made.
authors: Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, USA. dej84@comcast.net
authors: Dorothy E
authors: DE
authors: Jackson
authors: Linda M
authors: LM
authors: Berent
authors: Leah A
authors: LA
authors: Cohn
authors: David A
authors: DA
authors: Senter
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D002415:Cats; D003937:Diagnosis, Differential; D005260:Female; D018398:Homeodomain Proteins / Q000276:immunology; D007150:Immunohistochemistry / Q000662:veterinary; D008204:Lymphangiosarcoma / Q000175:diagnosis / Q000662:veterinary*; D009361:Neoplasm Invasiveness; D011859:Radiography; D013899:Thoracic Neoplasms / Q000175:diagnosis / Q000662:veterinary*; D025521:Tumor Suppressor Proteins / Q000276:immunology; D000098551:Prospero-Related Homeobox 1 Protein
chemical_list: D018398:Homeodomain Proteins; D025521:Tumor Suppressor Proteins; D000098551:Prospero-Related Homeobox 1 Protein