title: The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity.
abstract: Ever since the discovery of sirtuins a decade ago, interest in this family of NAD-dependent deacetylases has exploded, generating multiple lines of evidence implicating sirtuins as evolutionarily conserved regulators of lifespan. In mammals, it has been established that sirtuins regulate physiological responses to metabolism and stress, two key factors that affect the process of aging. Further investigation into the intimate connection among sirtuins, metabolism, and aging has implicated the activation of SIRT1 as both preventative and therapeutic measures against multiple age-associated disorders including type 2 diabetes and Alzheimer's disease. SIRT1 activation has clear potential to not only prevent age-associated diseases but also to extend healthspan and perhaps lifespan. Sirtuin activating compounds and NAD intermediates are two promising ways to achieve these elusive goals.
authors: Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors: Akiko
authors: A
authors: Satoh
authors: Liana
authors: L
authors: Stein
authors: Shin
authors: S
authors: Imai
mesh_terms: D000375:Aging / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D016922:Cellular Senescence / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects; D004789:Enzyme Activation; D020536:Enzyme Activators / Q000494:pharmacology; D006801:Humans; D008136:Longevity / Q000187:drug effects; D037761:Sirtuins / Q000378:metabolism*
chemical_list: D020536:Enzyme Activators; D037761:Sirtuins