title: MiR-142-3p as a potential prognostic biomarker for esophageal squamous cell carcinoma.
abstract: OBJECTIVE
  microRNAs (miRNAs), small non-coding RNAs, are always aberrantly expressed in many diseases including human cancers. The aim of this study was to examine and determine the clinical significance of hsa-miR-31, hsa-miR-142-3p, hsa-miR-338-3p, and hsa-miR-1261 expression in esophageal squamous cell carcinoma (ESCC).
  
  
  METHODS
  Expression levels of four selected miRNAs, initially evaluated by microarray, were validated by qRT-PCR. Various statistical methods were used to analyze the relationship between miRNA expression and clinicopathologic features and prognosis in 91 patients with ESCC.
  
  
  RESULTS
  MiR-31 and miR-142-3p expression were correlated to histological differentiation in ESCC (P < 0.05, Student's t-test); high miR-142-3p expression was associated with a poor prognosis in all 91 ESCC patients (P = 0.014, log-rank) and identified as an independent prognostic factor in ESCC (P = 0.017, univariate Cox; P = 0.022, multivariate Cox). More importantly, stratified analysis indicated that high miR-142-3p expression was correlated to a poor prognosis within good-prognosis groups comprised of ESCC patients with small tumor size, negative lymph node metastasis, or early stage (all P < 0.05).
  
  
  CONCLUSIONS
  The main findings suggest that miR-142-3p is involved in the progression of ESCC and is a potential prognostic biomarker for ESCC.
authors: Department of Cardiothoracic Surgery, the First Affiliated Hospital, Medical College of Shantou University, Shantou, Guangdong, PR China.
authors: Rui-Jun
authors: RJ
authors: Lin
authors: Da-Wei
authors: DW
authors: Xiao
authors: Lian-Di
authors: LD
authors: Liao
authors: Tao
authors: T
authors: Chen
authors: Ze-Feng
authors: ZF
authors: Xie
authors: Wei-Zhe
authors: WZ
authors: Huang
authors: Wei-Sen
authors: WS
authors: Wang
authors: Tai-Feng
authors: TF
authors: Jiang
authors: Bing-Li
authors: BL
authors: Wu
authors: En-Min
authors: EM
authors: Li
authors: Li-Yan
authors: LY
authors: Xu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D004947:Esophagus / Q000378:metabolism / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D020411:Oligonucleotide Array Sequence Analysis; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; C555159:MIRN142 microRNA, human; D035683:MicroRNAs; D012333:RNA, Messenger