title: Paraoxonase and arylesterase activity and total oxidative/anti-oxidative status in patients with chronic adenotonsillitis.
abstract: OBJECTIVE
  The aim of this study was to investigate serum paraoxonase, arylesterase activities along with determination of oxidative status via measurement of total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) in children with recurrent adenotonsillitis during pre- and post-adenotonsillectomy period and to compare results with data from healthy subjects.
  
  
  METHODS
  We performed a prospective controlled trial on adenoidectomy and/or tonsillectomy patients. A total of 47 subjects, including 22 patients with recurrent adenotonsillitis and 25 healthy controls were enrolled in this study. Peripheral venous blood samples were taken from patients before adenotonsillectomy and a second sample was obtained in first month postoperatively. In the control group, blood samples from healthy volunteers were collected for one time only. Serum paraoxonase, arylesterase activities, TOS, TAS and OSI levels were measured.
  
  
  RESULTS
  Paraoxonase, arylesterase activity, TAS and TOS levels were significantly higher in preoperative group compared to control group (P<0.001, P=0.003, 0.003 and 0.005, respectively). However, OSI level was similar in preoperative group compared to control group (P=0.25). In the post-operative group, paraoxonase, arylesterase activities, TAS and OSI levels were lower as compared to preoperative group but differences were statistically insignificant (P=0.483, 0.265, 0.149 and 0.090, respectively). TOS level in post-operative group was significantly lower than the preoperative group (P<0.001). In the post-operative group, paraoxonase and arylesterase activities were significantly higher as compared to control group (P=0.004 and 0.02, respectively). TOS and OSI levels were significantly lower in post-operative group compared to control group (P=0.001 and 0.02, respectively). However, TAS was similar between post-operative and control groups (P=0.464).
  
  
  CONCLUSIONS
  Based on data obtained from this study, we may state that paraoxonase, arylesterase activities with TAS, TOS and OSI levels of patients with chronic adenotonsillitis shows alterations due to oxidant/antioxidant imbalance induced by frequent infections.
authors: Gaziosmanpasa University, School of Medicine, Department of Otorhinolaryngology, Tokat, Turkey. drsemakoc@mynet.com
authors: Sema
authors: S
authors: Koc
authors: Nurten
authors: N
authors: Aksoy
authors: Hasan
authors: H
authors: Bilinc
authors: Fazilet
authors: F
authors: Duygu
authors: Ismail Önder
authors: IÖ
authors: Uysal
authors: Adnan
authors: A
authors: Ekinci
mesh_terms: D000233:Adenoidectomy / Q000379:methods; D000234:Adenoids / Q000503:physiopathology / Q000601:surgery; D000293:Adolescent; D043303:Aryldialkylphosphatase / Q000097:blood* / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D002265:Carboxylic Ester Hydrolases / Q000097:blood* / Q000378:metabolism; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009304:Nasopharyngitis / Q000175:diagnosis / Q000201:enzymology* / Q000601:surgery; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*; D011446:Prospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D014068:Tonsillectomy / Q000379:methods; D014069:Tonsillitis / Q000175:diagnosis / Q000201:enzymology* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase