title: Enhanced effect of platelet-rich plasma containing a new carrier on hair growth.
abstract: BACKGROUND
  Treatments for alopecia are in high demand, but not all are safe and reliable. Dalteparin and protamine microparticles (D/P MPs) can effectively carry growth factors (GFs) in platelet-rich plasma (PRP).
  
  
  OBJECTIVE
  To identify the effects of PRP-containing D/P MPs (PRP&D/P MPs) on hair growth.
  
  
  METHODS
  Participants were 26 volunteers with thin hair who received five local treatments of 3 mL of PRP&D/P MPs (13 participants) or PRP and saline (control, 13 participants) at 2- to 3-week intervals and were evaluated for 12 weeks. Injected areas comprised frontal or parietal sites with lanugo-like hair. Experimental and control areas were photographed. Consenting participants underwent biopsies for histologic examination.
  
  
  RESULTS
  D/P MPs bind to various GFs contained in PRP. Significant differences were seen in hair cross-section but not in hair numbers in PRP and PRP&D/P MP injections. The addition of D/P MPs to PRP resulted in significant stimulation in hair cross-section. Microscopic findings showed thickened epithelium, proliferation of collagen fibers and fibroblasts, and increased vessels around follicles.
  
  
  CONCLUSIONS
  PRP&D/P MPs and PRP facilitated hair growth but D/P MPs provided additional hair growth. The authors have indicated no significant interest with commercial supporters.
authors: Department of Plastic Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan.
authors: Megumi
authors: M
authors: Takikawa
authors: Shinichiro
authors: S
authors: Nakamura
authors: Shingo
authors: S
authors: Nakamura
authors: Masayuki
authors: M
authors: Ishirara
authors: Satoko
authors: S
authors: Kishimoto
authors: Kaoru
authors: K
authors: Sasaki
authors: Satoshi
authors: S
authors: Yanagibayashi
authors: Ryuichi
authors: R
authors: Azuma
authors: Naoto
authors: N
authors: Yamamoto
authors: Tomoharu
authors: T
authors: Kiyosawa
mesh_terms: D000328:Adult; D017985:Dalteparin / Q000008:administration & dosage*; D005260:Female; D006197:Hair / Q000254:growth & development*; D006801:Humans; D007279:Injections, Subcutaneous; D036341:Intercellular Signaling Peptides and Proteins / Q000032:analysis / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D053657:Platelet-Rich Plasma / Q000737:chemistry; D011479:Protamines / Q000008:administration & dosage*; D011485:Protein Binding; D012535:Scalp
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D011479:Protamines; D017985:Dalteparin