title: The first dominant co-circulation of both dengue and chikungunya viruses during the post-monsoon period of 2010 in Delhi, India.
abstract: Independent outbreaks of dengue virus (DENV) infection and sporadic cases of chikungunya virus (CHIKV) have been recorded in the metropolitan city of Delhi on several occasions in the past. However, during a recent 2010 arboviral outbreak in Delhi many cases turned negative for DENV. This prompted us to use duplex reverse transcriptase-polymerase chain reaction (D-RT-PCR) to establish the aetiology of dengue/chikungunya through sequencing of CprM and E1 genes of dengue and chikungunya viruses. Interestingly, for the first time, both DENV and CHIKV co-circulated simultaneously and in equally dominant proportion during the post-monsoon period of 2010. DENV-1 genotype III and the East Central South African genotype of CHIKV were associated with post-monsoon spread of these viruses.
authors: Division of Biochemistry & Biotechnology, National Centre for Disease Control 22, Sham Nath Marg, Delhi, India.
authors: P
authors: P
authors: Singh
authors: V
authors: V
authors: Mittal
authors: M M A
authors: MM
authors: Rizvi
authors: M
authors: M
authors: Chhabra
authors: P
authors: P
authors: Sharma
authors: D S
authors: DS
authors: Rawat
authors: D
authors: D
authors: Bhattacharya
authors: L S
authors: LS
authors: Chauhan
authors: A
authors: A
authors: Rai
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018354:Alphavirus Infections / Q000453:epidemiology* / Q000821:virology; D065632:Chikungunya Fever; D002646:Chikungunya virus / Q000302:isolation & purification*; D002648:Child; D002980:Climate; D003715:Dengue / Q000453:epidemiology* / Q000821:virology; D003716:Dengue Virus / Q000302:isolation & purification*; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D060885:Multiplex Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012621:Seasons; D017422:Sequence Analysis, DNA; D014764:Viral Proteins / Q000235:genetics; D055815:Young Adult
chemical_list: D014764:Viral Proteins