title: Impact of lipophilic antioxidants and level of antibodies against oxidized low-density lipoprotein in Polish children with phenylketonuria.
abstract: The treatment of phenylketonuria (PKU) patients constitutes a phenylalanine (Phe) intake restriction in their diet, which is achieved by adding a special Phe-free amino acid mixture to the diet. It has been reported that this diet could have some micronutrient deficiency. Several authors have also reported an increased oxidative stress or impaired antioxidant status in human and experimental PKU. Our project assessed the concentrations of retinol, alpha-tocopherol, coenzyme Q10, and anti-oxidized low-density lipoprotein (ox-LDL) antibodies in PKU children's plasma. It was found that retinol concentration in PKU children remains within the norm despite a low intake. The lower plasma alpha-tocopherol concentration in PKU children compared with normal children was associated with the lower level of antibodies against ox-LDL. This raises the question whether higher than observed circulatory alpha-tocopherol is indeed beneficial to lower plasma ox-LDL levels. Further studies are needed to explain the genetic factor in PKU patients (e.g., CD36/FAT polymorphism gene). The open clinical question is whether daily supplementation of alpha-tocopherol changes the PKU patients' level of antibodies against ox-LDL.
authors: Department of Pediatrics and Developmental Disorders in Children and Adolescents, Medical University of Bialystok, Poland. radek@hoga.pl
authors: Bozena
authors: B
authors: Mikoluc
authors: Radoslaw
authors: R
authors: Motkowski
authors: Joanna
authors: J
authors: Karpinska
authors: Jolanta
authors: J
authors: Amilkiewicz
authors: Bozena
authors: B
authors: Didycz
authors: Maria
authors: M
authors: Gizewska
authors: Agata
authors: A
authors: Lange
authors: Andrzej
authors: A
authors: Milanowski
authors: Maria
authors: M
authors: Nowacka
authors: Dorota
authors: D
authors: Sands
authors: Barbara
authors: B
authors: Schneiberg
authors: Ewa
authors: E
authors: Starostecka
authors: Iwona
authors: I
authors: Wojcicka-Bartlomiejczyk
authors: Janina
authors: J
authors: Piotrowska-Jastrzebska
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D001323:Autoantibodies / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008077:Lipoproteins, LDL / Q000276:immunology*; D008297:Male; D010661:Phenylketonurias / Q000097:blood*
chemical_list: D000975:Antioxidants; D001323:Autoantibodies; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein