title: [Study of prognostic factors in the hepatectomy for metastases of colorectal carcinoma--analysis of two scores].
abstract: BACKGROUND
  Resection is the treatment of choice for colorectal cancer liver metastases.
  
  
  OBJECTIVE
  This is a retrospective, longitudinal, retrospective analysis of different prognostic factors for survival in a consecutive series of liver resection for metastatic colorectal carcinoma.
  
  
  METHODS
  Between October 1998 and November 2007, we performed 89 liver resections for colorectal metastases. A retrospective analysis from the liver resection database was performed and the variables analyzed were related to demography, primary tumor and surgical procedure. Survival analysis was performed according to the Fong and Basingstoke scores.
  
  
  RESULTS
  The mean age of patients was 60.5 years and 67.4% were men. The primary tumor was localized in the colon in 73% of cases. In 68.5% the metastases were metachronous. The right hemiliver was involved in 46 patients (52%). Major hepatectomy was performed in 36 (40.2%), minor in 55 (59.8%) and combined procedures in 14 (15.7%). Seventy-seven (86.5%) R0 resections were achieved. Morbidity was 32.6%, with no perioperative mortality. Average follow-up was 32.5 months (range 1 to 158 months), with a median of 25.5 months. Median overall survival was 69.7 months and mean disease-free survival 58.7 months. Multivariate analysis found statistical significance for blood product requirement and margin of resection. Thirty-four patients are alive at the end of this study (45.9%). The Basingstoke predictive index for postoperative variables showed significant differences that were not demonstrated by the Fong clinical score on prognostic factors.
  
  
  CONCLUSIONS
  The application of Basingstoke predictive index and Fong score with biomarkers may indicate the most appropriate therapeutic strategy in each patient with colorectal liver metastases.
authors: Unidad de Trasplante y Cirugía Hepática, Hospital Dr Cosme Argerich, Ciudad Autónoma de Buenos Aires, Argentina.
authors: Javier
authors: J
authors: Lendoire
authors: Gabriel
authors: G
authors: Raffin
authors: Fernando
authors: F
authors: Duek
authors: Pablo
authors: P
authors: Barros Schelotto
authors: Carlos
authors: C
authors: Quarin
authors: Verónica
authors: V
authors: Garay
authors: Luis
authors: L
authors: Gil
authors: Oscar
authors: O
authors: Imventarza
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms; D004812:Epidemiologic Methods; D005260:Female; D006498:Hepatectomy / Q000401:mortality*; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality* / Q000556:secondary / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis