title: No genetic association between SLC7A10 and Japanese patients with schizophrenia.
abstract: Disrupted glutamatergic neurotransmission may be a pathophysiological feature in the brains from patients with schizophrenia, and glutamatergic amino acids including D-serine have been found to be involved in pathophysiology. Endogenous and exogenous D-serine have shown potential as biological markers for the pathophysiology of schizophrenia and especially as a therapeutic strategy in treatment-resistant schizophrenia (TRS). This is the first study investigating whether SLC7A10, a d-serine transporter gene, is associated with schizophrenia in Japanese patients. We investigated the association between schizophrenia in Japanese patients with SLC7A10 using six tag single nucleotide polymorphisms (SNPs). Results failed to show any association between Japanese schizophrenia and each individual SNP or with two-, three-, or four-window haplotype analyses. We also investigated whether SLC7A10 contributes to TRS in Japanese participants. Results showed no association. In conclusion, SLC7A10 had no apparent degree of association with schizophrenia as a candidate susceptibility gene in the disease per se.
authors: Juntendo University Schizophrenia Projects (JUSP), Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan.
authors: Yuto
authors: Y
authors: Takebayashi
authors: Tohru
authors: T
authors: Ohnuma
authors: Ryo
authors: R
authors: Hanzawa
authors: Nobuto
authors: N
authors: Shibata
authors: Hitoshi
authors: H
authors: Maeshima
authors: Hajime
authors: H
authors: Baba
authors: Tokiko
authors: T
authors: Hatano
authors: Yuri
authors: Y
authors: Hotta
authors: Maiko
authors: M
authors: Kitazawa
authors: Motoyuki
authors: M
authors: Higa
authors: Heii
authors: H
authors: Arai
mesh_terms: D000328:Adult; D000368:Aged; D027182:Amino Acid Transport System y+ / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007564:Japan; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D027182:Amino Acid Transport System y+; C498799:SLC7A10 protein, human