title: Respiratory health and endotoxin: associations and modification by CD14/-260 genotype.
abstract: Exposure to endotoxin has been associated with increased respiratory symptoms and decrements in lung function in occupational settings but little is known about the health effects of domestic exposure in adults. Here, we describe the association of respiratory disease, immunoglobulin (Ig)E sensitisation, bronchial reactivity and lung function with mattress endotoxin levels in adults, and determine whether these associations are modified by polymorphisms in CD14. Endotoxin levels in mattress dust from a population-based sample of 972 adults were measured. Associations were examined using generalised linear mixed models, adjusting for individual and household confounders. Effect modification of these associations by CD14/-260 (rs2569190) was assessed. Mattress endotoxin levels varied from 0.1 to 402.6 EU · mg(-1). Although there was no overall association of lung function with endotoxin exposure, there was evidence that the association of forced expiratory volume in 1 s and forced vital capacity with endotoxin was modified by CD14/-260 genotype (p-value for interaction 0.005 and 0.013, respectively). There was no evidence that symptoms, IgE sensitisation or bronchial reactivity were associated with mattress endotoxin levels. In this large epidemiological study of adults, there was no evidence that mattress endotoxin level was associated with respiratory symptoms or IgE sensitisation but the association of lung function with endotoxin levels may be modified by CD14 genotype.
authors: Respiratory Epidemiology and Public Health Group National Heart and Lung Institute, Imperial College, Emmanuel Kaye Building, Manresa Road, London SW3 6LR, UK. i.bakolis@imperial.ac.uk
authors: I
authors: I
authors: Bakolis
authors: G
authors: G
authors: Doekes
authors: J
authors: J
authors: Heinrich
authors: J P
authors: JP
authors: Zock
authors: D
authors: D
authors: Heederik
authors: M
authors: M
authors: Kogevinas
authors: S
authors: S
authors: Guerra
authors: D
authors: D
authors: Norbäck
authors: A
authors: A
authors: Ramasamy
authors: A
authors: A
authors: Nevalainen
authors: C
authors: C
authors: Svanes
authors: C M
authors: CM
authors: Chen
authors: G
authors: G
authors: Verlato
authors: M
authors: M
authors: Olivieri
authors: F
authors: F
authors: Castro-Giner
authors: D
authors: D
authors: Jarvis
mesh_terms: D000328:Adult; D001249:Asthma / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology*; D001513:Beds / Q000009:adverse effects; D016535:Bronchial Hyperreactivity / Q000453:epidemiology / Q000235:genetics / Q000276:immunology*; D001985:Bronchial Provocation Tests; D004731:Endotoxins / Q000276:immunology*; D005260:Female; D005541:Forced Expiratory Volume / Q000235:genetics / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D018950:Lipopolysaccharide Receptors / Q000235:genetics* / Q000276:immunology; D008168:Lung / Q000276:immunology / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence
chemical_list: D004731:Endotoxins; D018950:Lipopolysaccharide Receptors; D007073:Immunoglobulin E