title: Association of survivin gene polymorphism with endometrial cancer.
abstract: OBJECTIVE
  Survivin is an inhibitor of apoptosis protein, which is up-regulated in endometrial cancer (EC). A promoter region polymorphism (-31G/C) in the survivin gene has been reported as a modulator of gene expression. The aim of this study was to explore the frequency of survivin -31G/C polymorphism in tumor tissues from patients with EC in an Iranian population compared to that of healthy controls.
  
  
  METHODS
  Paraffin-embedded tissue sections from patients diagnosed with EC (n = 31) and healthy controls (n = 30) were examined. Genotyping for survivin -31G/C polymorphism was performed using polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP).
  
  
  RESULTS
  The presence of allele C was found to be significantly increased in EC tissues compared to the healthy tissues (GG vs GC + CC, P = 0. 01; OR, 3.6; 95% CI, 1.1-11.9).
  
  
  CONCLUSIONS
  Our data are in keeping with a previous finding regarding the role of survivin gene polymorphism in malignancies. This finding highlights the role of survivin in pathogenesis of various carcinomas, which might have therapeutic implications.
authors: Endocrinology and Metabolism Research Centre, Tehran, Iran.
authors: Parisa
authors: P
authors: Zahedi
authors: Soheila
authors: S
authors: Aminimoghaddam
authors: Forough A
authors: FA
authors: Sayahpour
authors: Vahid
authors: V
authors: Haghpanah
authors: Parvin
authors: P
authors: Amiri
authors: Forozandeh
authors: F
authors: Fereidoni
authors: Elnaz
authors: E
authors: Mahrampour
authors: Bagher
authors: B
authors: Larijani
authors: Javad
authors: J
authors: Tavakkoly-Bazzaz
authors: Mahsa M
authors: MM
authors: Amoli
mesh_terms: D000368:Aged; D054458:Amplified Fragment Length Polymorphism Analysis; D014408:Biomarkers, Tumor / Q000235:genetics*; D016022:Case-Control Studies; D016889:Endometrial Neoplasms / Q000235:genetics*; D005260:Female; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000235:genetics*; D007492:Iran; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D000077022:Survivin
chemical_list: C107489:BIRC5 protein, human; D014408:Biomarkers, Tumor; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin