title: Total synthesis of pacidamycin D by Cu(I)-catalyzed oxy enamide formation.
abstract: The first total synthesis of pacidamycin D, which is expected to be a good candidate as an antibacterial agent against P. aeruginosa, is described. The key elements of our approach feature an efficient and stereocontrolled construction of the Z-oxyvinyl iodide and copper-catalyzed cross-coupling with the tetrapeptide carboxamide.
authors: Shionogi Innovation Center for Drug Discovery, Shionogi & Co., Ltd., Kita-21 Nishi-11, Sapporo 001-0021, Japan.
authors: Kazuya
authors: K
authors: Okamoto
authors: Masahiro
authors: M
authors: Sakagami
authors: Fei
authors: F
authors: Feng
authors: Hiroko
authors: H
authors: Togame
authors: Hiroshi
authors: H
authors: Takemoto
authors: Satoshi
authors: S
authors: Ichikawa
authors: Akira
authors: A
authors: Matsuda
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*; D011741:Pyrimidine Nucleosides / Q000737:chemistry*
chemical_list: D010455:Peptides; D011741:Pyrimidine Nucleosides; C059936:pacidamycin 1; D003300:Copper