title: The single source architecture x4T to connect medical documentation and clinical research.
abstract: Clinical trials often require large and redundant documentation efforts, because information systems in patient care and research are separated. In two clinical trials we have assessed the number of study items available in the clinical information system for re-use in clinical research. We have analysed common standards such as HL7, IHE RFD and CDISC ODM, regulatory constraints and the documentation process. Based on this analysis we have designed and implemented an architecture for an integrated clinical trial documentation workflow. Key aspects are the re-use of existing medical routine data and the integration into current documentation workflows.
authors: Department of Medical Informatics, University of Münster, Germany. philipp.dziuballe@ukmuenster.de
authors: Philipp
authors: P
authors: Dziuballe
authors: Christian
authors: C
authors: Forster
authors: Bernhard
authors: B
authors: Breil
authors: Volker
authors: V
authors: Thiemann
authors: Fleur
authors: F
authors: Fritz
authors: Jens
authors: J
authors: Lechtenbörger
authors: Gottfried
authors: G
authors: Vossen
authors: Martin
authors: M
authors: Dugas
mesh_terms: D035843:Biomedical Research; D004282:Documentation; D057208:Health Level Seven; D006751:Hospital Information Systems; D006801:Humans; D007256:Information Systems; D008490:Medical Informatics / Q000379:methods*; D016347:Medical Records Systems, Computerized / Q000592:standards; D015337:Multicenter Studies as Topic; D016730:Program Development; D015397:Program Evaluation; D015203:Reproducibility of Results; D012107:Research Design; D012984:Software; D018511:Systems Integration