title: [Value of HPV (hybrid capture 2) testing for assessing the effectiveness of conservative surgical treatment in CIN2-3/carcinoma in situ and microinvasive cervical cancer].
abstract: The prospective study in 525 patients with CIN2-3/CIS and microinvasive cervical cancer showed the association of epithelial lesions with HPV HR in almost all cases. This allowed using HPV-testing for conservative surgical treatment (ablation, LEEP/ LLETZ, conization) efficacy assessment and patient follow-up. The value of HPV-testing for residual disease and recurrence detection was higher that of cytology and colposcopy. HPV-testing showed 100% sensitivity and negative predictive value. Hybrid Capture 2 test was more useful for residual disease and recurrence detection than PCR, showed higher specificity (96% vs. 79,2%) and positive predictive value (44.8% vs. 13.4%). After conservative surgical treatment of CIN2-3/carcinoma in situ and microinvasive cervical cancer Hybride Capture 2 is to become negative thus confirming the adequacy of neoplastic tissue excision.
authors: L I
authors: LI
authors: Korolenkova
mesh_terms: D000328:Adult; D052685:Alphapapillomavirus / Q000302:isolation & purification*; D003127:Colposcopy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009693:Nucleic Acid Hybridization / Q000379:methods; D030361:Papillomavirus Infections / Q000150:complications; D016133:Polymerase Chain Reaction; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D014412:Tumor Virus Infections / Q000150:complications; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery* / Q000821:virology; D002578:Uterine Cervical Dysplasia / Q000473:pathology* / Q000601:surgery* / Q000821:virology