title: [Development of aseptic osteonecrosis during the treatment of acute lymphoblastic leukemia: review of the literature and author's own data].
abstract: We report a case of aceptic osteonecrosis (AON) of the left hymerus epiphysis in programmed treatment of a male patient with lymphoblastic lymphoma to illustrate clinical, laboratory, epidemiological, pathogenetic, diagnostic and therapeutic aspects of AON in programmed therapy of acute lymphoblastic leukemia (ALL). We believe that AON is a rather frequent but often missed for early diagnosis complication of ALL treatment. Even a weak pain in bones and joints under mechanical load in patients on long-term treatment with glucocorticosteroids is an alarming symptom which may indicate a risk of an osteodestructive process and relevant diagnostic and therapeutic measures may be needed.
authors: O Iu
authors: OIu
authors: Baranova
authors: A D
authors: AD
authors: Shirin
authors: N A
authors: NA
authors: Falaleeva
authors: D Sh
authors: DSh
authors: Osmanov
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010020:Osteonecrosis / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000209:etiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D011859:Radiography; D012307:Risk Factors