title: [Intrafamilial transmission of Staphylococcus aureus Panton-Valentine leukocidin responsible for two cases of neonatal necrotizing pneumonia].
abstract: Necrotizing Staphylococcus aureus Panton-Valentine leukocidin (SA-PLV+) accounts for less than 1% of community-acquired lung diseases in children and young adults. Neonatal cases are exceptional. We report the observations of two newborn female twins, who were not breastfed, presenting a necrotizing lung disease due to the same strain of SA-PVL+ despite nasal decolonization measures taken. These two cases are informative and bring to light (1) the possibility of severe SA-PVL+ lung infections in young infants and (2) their strictly intrafamilial mode of transmission for which eradication measures were ineffective.
authors: Service de pédiatrie, pneumologie, allergologie, mucoviscidose, hôpital Femme-Mère-Enfant, hospices civils de Lyon, 59, boulevard Pinel, 69677 Bron, France.
authors: G
authors: G
authors: Catho
authors: Y
authors: Y
authors: Gillet
authors: O
authors: O
authors: Dumitrescu
authors: G
authors: G
authors: Lina
authors: G
authors: G
authors: Labbé
authors: G
authors: G
authors: Bellon
authors: P
authors: P
authors: Reix
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001427:Bacterial Toxins / Q000378:metabolism*; D017714:Community-Acquired Infections / Q000517:prevention & control; D005098:Exotoxins / Q000378:metabolism*; D005190:Family; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007956:Leukocidins / Q000378:metabolism*; D008826:Microbial Sensitivity Tests; D009336:Necrosis; D011023:Pneumonia, Staphylococcal / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology / Q000635:transmission*; D011859:Radiography; D013211:Staphylococcus aureus / Q000378:metabolism* / Q000472:pathogenicity; D016896:Treatment Outcome; D014430:Twins, Monozygotic
chemical_list: D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin