title: Synthesis and cytotoxicity evaluation of novel podophyllotoxin derivatives.
abstract: Seven benzylamino derivatives of podophyllotoxin 8a-8g were synthesized and their chemical structures were confirmed by IR, ¹H-NMR, (13)C-NMR and ESI-MS spectral analyses. Their abilities to inhibit the growth of cancer cells A549, HCT-116 and HepG2, were investigated by MTT assay. Compound 8b possessed the highest cytotoxicity on cancer cell lines with average IC(50) values of 3.8 µM. All we synthetic compounds were cytotoxic against three cancer cell lines at the micromolar range, indicating podophyllotoxin derivatives with structural modification of benzylamino possess potent antitumor activity.
authors: Institute of Nautical Medicine, Nantong University, Nantong, P.R. China.
authors: Wang
authors: W
authors: Chengniu
authors: Wu
authors: W
authors: Zhonghua
authors: Zhao
authors: Z
authors: Yu
authors: Ni
authors: N
authors: Chunyan
authors: Zhao
authors: Z
authors: Xiaodong
authors: Zhu
authors: Z
authors: Li
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D045325:HCT116 Cells; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D011034:Podophyllotoxin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D011034:Podophyllotoxin