title: T1rho MRI of menisci and cartilage in patients with osteoarthritis at 3T.
abstract: OBJECTIVE
  To assess and compare subregional and whole T1rho values (median±interquartile range) of femorotibial cartilage and menisci in patients with doubtful (Kellgren-Lawrence (KL) grade 1) to severe (KL4) osteoarthritis (OA) at 3T.
  
  
  METHODS
  30 subjects with varying degrees of OA (KL1-4, 13 females, 17 males, mean age±SD=63.9±13.1 years) were evaluated on a 3T MR scanner using a spin-lock-based 3D GRE sequence for T1rho mapping. Clinical proton density (PD)-weighted fast spin echo (FSE) images in sagittal (without fat saturation), axial, and coronal (fat-saturated) planes were acquired for cartilage and meniscus Whole-organ MR imaging score (WORMS) grading. Wilcoxon rank sum test was performed to determine whether there were any statistically significant differences between subregional and whole T1rho values of femorotibial cartilage and menisci in subjects with doubtful to severe OA.
  
  
  RESULTS
  Lateral (72±10 ms, median±interquartile range) and medial (65±10 ms) femoral anterior cartilage subregions in moderate-severe OA subjects had significantly higher T1rho values (P<0.05) than cartilage subregions and whole femorotibial cartilage in doubtful-minimal OA subjects. There were statistically significant differences in meniscus T1rho values of the medial posterior subregion of subjects with moderate-severe OA and T1rho values of all subregions and the whole meniscus in subjects with doubtful-minimal OA. When evaluated based on WORMS, statistically significant differences were identified in T1rho values between the lateral femoral anterior cartilage subregion in patients with WORMS5-6 (advanced degeneration) and whole femorotibial cartilage and all cartilage subregions in patients with WORMS0-1 (normal).
  
  
  CONCLUSIONS
  T1rho values are higher in specific meniscus and femorotibial cartilage subregions. These findings suggest that regional damage of both femorotibial hyaline cartilage and menisci may be associated with osteoarthritis.
authors: Quantitative Multinuclear Musculoskeletal Imaging Group (QMMIG), Department of Radiology, New York University Langone Medical Center, New York, NY 10016, USA. ligong.wang@nyumc.org
authors: Ligong
authors: L
authors: Wang
authors: Gregory
authors: G
authors: Chang
authors: Jian
authors: J
authors: Xu
authors: Renata L R
authors: RL
authors: Vieira
authors: Svetlana
authors: S
authors: Krasnokutsky
authors: Steven
authors: S
authors: Abramson
authors: Ravinder R
authors: RR
authors: Regatte
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002358:Cartilage, Articular / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008592:Menisci, Tibial / Q000473:pathology*; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity