title: Nanoparticles targeting the infarcted heart.
abstract: We report a nanoparticulate system capable of targeting the heart after myocardial infarction (MI). Targeting is based on overexpression of angiotensin II type 1 (AT1) receptor in the infarcted heart. Liposomes 142 nm in diameter were conjugated with a ligand specific to AT1. The nanoparticles were able to specifically target cardiac cells in vitro, and in the infarcted heart after intravenous injection in vivo. This system may be useful for delivering therapeutic agents specifically to the infarcted heart.
authors: Department of Chemical Engineering, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.
authors: Tal
authors: T
authors: Dvir
authors: Michael
authors: M
authors: Bauer
authors: Avi
authors: A
authors: Schroeder
authors: Jonathan H
authors: JH
authors: Tsui
authors: Daniel G
authors: DG
authors: Anderson
authors: Robert
authors: R
authors: Langer
authors: Ronglih
authors: R
authors: Liao
authors: Daniel S
authors: DS
authors: Kohane
mesh_terms: D000818:Animals; D002317:Cardiovascular Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D016503:Drug Delivery Systems; D006801:Humans; D008081:Liposomes; D009203:Myocardial Infarction / Q000188:drug therapy*; D053758:Nanoparticles; D051381:Rats
chemical_list: D002317:Cardiovascular Agents; D008081:Liposomes