title: Hepatocellular carcinoma: clinical and radiological findings in patients with chronic B viral hepatitis and chronic C viral hepatitis.
abstract: OBJECTIVE
  To compare clinical and radiological findings of newly diagnosed hepatocellular carcinomas (HCCs) in patients with chronic hepatitis B virus (HBV) and chronic hepatitis C virus (HCV) infections.
  
  
  METHODS
  Dynamic contrast-enhanced CT images in 532 patients with newly diagnosed HCC were retrospectively reviewed. Of these patients, 418 had chronic HBV infections and 114 had chronic HCV infections. The number, size, shape (nodular vs. non-nodular) and enhancement pattern (typical vs. atypical) of hepatic lesions were assessed. The presence of portal vein thrombosis and bile duct invasion were determined.
  
  
  RESULTS
  The mean age of the HBV group (54.31 [range 27-85], median 54) was younger than that of the HCV group (64.21 [range 30-86], median 64) (P < 0.001). Lesions in patients with HBV were more likely to be multifocal (>5; P < 0.001); larger than 5 cm (P = 0.023); non-nodular shape (P < 0.001); atypical enhancement pattern (P = 0.047), association with portal vein thrombosis (P = 0.004); association with bile duct invasion (P < 0.001).
  
  
  CONCLUSIONS
  Clinical and radiological findings of HCC differ between patients with HBV and HCV infections.
authors: Department of Radiology, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors: Kyung Eun
authors: KE
authors: Kim
authors: Mi-Suk
authors: MS
authors: Park
authors: Stuart
authors: S
authors: Bentley-Hibbert
authors: Song-Ee
authors: SE
authors: Baek
authors: Young Chul
authors: YC
authors: Kim
authors: Myeong-Jin
authors: MJ
authors: Kim
authors: Ki Whang
authors: KW
authors: Kim
authors: Yong H
authors: YH
authors: Auh
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001652:Bile Ducts / Q000473:pathology; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications*; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D011859:Radiography; D012189:Retrospective Studies