title: Association between uterus uni/bicornis in pregnant women and postural deformities in their offspring.
abstract: OBJECTIVE
  The objective of the investigation was to study the possible association between uterus uni- or bicornis in pregnant women and structural birth defects (ie, congenital abnormalities) in their offspring.
  
  
  METHODS
  There were 22,843 cases with congenital abnormality recorded in the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1996. These subjects were matched to 38,151 controls without any defect. Prevalence of medically recorded uterus uni/bicornis in the prenatal maternity logbook in the mothers of subjects with different congenital abnormalities and of their matched controls without any defect were compared.
  
  
  RESULTS
  Fifty-seven (0.25%) subjects and 67 (0.18%) controls had mothers with uterus uni/bicornis. There was a significant association of uterus uni/bicornis in pregnant women with a higher risk of total group of congenital abnormalities (adjusted odds ratio, 1.5; 95% confidence interval, 1.1-2.2) explained mainly by a significantly higher risk of clubfoot and particularly postural deformity association in their children (adjusted odds ratio, 4.7; 95% confidence interval, 2.4-9.1).
  
  
  CONCLUSIONS
  Pregnant women with a uni/bicornis uterus have a significantly higher risk of clubfoot and postural deformity association.
authors: Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary. czeizel@interware.hu
authors: Andrew E
authors: AE
authors: Czeizel
authors: Erzsébet H
authors: EH
authors: Puhó
authors: Abdallah
authors: A
authors: Dakhlaoiu
authors: Ferenc
authors: F
authors: Bánhidy
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003025:Clubfoot / Q000453:epidemiology*; D000013:Congenital Abnormalities / Q000453:epidemiology*; D005260:Female; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D015994:Incidence; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D011187:Posture; D011247:Pregnancy; D047928:Premature Birth / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors; D014591:Uterine Diseases / Q000453:epidemiology* / Q000473:pathology; D014599:Uterus / Q000002:abnormalities*; D055815:Young Adult