title: Anti-hepatitis B virus and cytotoxic diterpenoids from Isodon lophanthoides var. gerardianus.
abstract: Four new diterpenoides, isolophanthins A-D (1-4) together with seven known abietane diterpenoides (5-11), have been isolated from Isodon lophanthoides var. gerardianus. The new diterpenoides were elucidated by spectroscopic analysis. Some of them showed significant activities against HBsAg and HBeAg of hepatitis B virus in Hep G 2.2.15 cells, as well as the human tumor cell lines, HL-60, A-549, MOLT-4, and BEL-7402.
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences.
authors: Li-bin
authors: LB
authors: Yang
authors: Lin
authors: L
authors: Li
authors: Sheng-xiong
authors: SX
authors: Huang
authors: Jian-xin
authors: JX
authors: Pu
authors: Yong
authors: Y
authors: Zhao
authors: Yun-bao
authors: YB
authors: Ma
authors: Ji-jun
authors: JJ
authors: Chen
authors: Chun-hong
authors: CH
authors: Leng
authors: Zheng-ming
authors: ZM
authors: Tao
authors: Han-dong
authors: HD
authors: Sun
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D004354:Drug Screening Assays, Antitumor; D006514:Hepatitis B Surface Antigens / Q000187:drug effects; D006513:Hepatitis B e Antigens / Q000187:drug effects; D006515:Hepatitis B virus / Q000187:drug effects*; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D035261:Plant Components, Aerial / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000998:Antiviral Agents; D004224:Diterpenes; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens