title: The strategy of antibiotic use in critically ill neutropenic patients.
abstract: Suspicion of sepsis in neutropenic patients requires immediate antimicrobial treatment. The initial regimen in critically ill patients should cover both Gram-positive and Gram-negative pathogens, including Pseudomonas aeruginosa. However, the risk of selecting multidrug-resistant pathogens should be considered when using broad-spectrum antibiotics for a prolonged period of time. The choice of the first-line empirical drugs should take into account the underlying malignancy, local bacterial ecology, clinical presentation and severity of acute illness. This review provides an up-to-date guide that will assist physicians in choosing the best strategy regarding the use of antibiotics in neutropenic patients, with a special focus on critically ill patients, based on the above-mentioned considerations and on the most recent international guidelines and literature.
authors: Department of Intensive Care and Infectious Diseases, Institut Gustave Roussy, 39, rue Camille Desmoulins, 94805 Villejuif cedex, France. gachot@igr.fr.
authors: Matthieu
authors: M
authors: Legrand
authors: Adeline
authors: A
authors: Max
authors: Benoît
authors: B
authors: Schlemmer
authors: Elie
authors: E
authors: Azoulay
authors: Bertrand
authors: B
authors: Gachot