title: Thiolato gold(I) complexes containing water-soluble phosphane ligands: a characterization of their chemical and biological properties.
abstract: A series of thiolate gold(I) derivatives bearing water soluble phosphanes--namely sodium triphenylphosphane monosulfonate (TPPMS), sodium triphenylphosphane trisulfonate (TPPTS), 1,3,5-triaza-7-phosphaadamantane (PTA) and 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane (DAPTA)--is reported and the compounds studied for their luminescence properties in the solid state. Two of these derivatives, [Au(SMe(2)pyrim)(PTA)] and [Au(SBenzoxazole)(DAPTA)], are also structurally characterized by X-ray diffraction analysis. Strong antiproliferative effects are observed for most of the compounds in the human ovarian carcinoma cell lines (A2780/S) and its cisplatin-resistant variant (A2780/R), which depend on both the type of thiolate and phosphane ligands. ICP-MS studies were also performed to evaluate the influence of the gold uptake on the cytotoxic potency of the compounds.
authors: Departamento de Química Inorgánica, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH)-C.S.I.C, Universidad de Zaragoza, 50009, Zaragoza, Spain.
authors: Elena
authors: E
authors: Vergara
authors: Elena
authors: E
authors: Cerrada
authors: Catherine
authors: C
authors: Clavel
authors: Angela
authors: A
authors: Casini
authors: Mariano
authors: M
authors: Laguna
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D019008:Drug Resistance, Neoplasm; D005260:Female; D006046:Gold / Q000737:chemistry*; D006801:Humans; D008024:Ligands; D008968:Molecular Conformation; D010051:Ovarian Neoplasms; D010720:Phosphines / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D008024:Ligands; D010720:Phosphines; D014867:Water; D006046:Gold; C044646:phosphine; D002945:Cisplatin