title: Induction of regulatory Tr1 cells and inhibition of T(H)17 cells by IL-27.
abstract: Accumulating evidence indicates that IL-27, a member of the IL-12 family of cytokines, alleviates the severity of autoimmune diseases in both mice and men. The IL-27-induced activation of signal transducer and activator of transcription (Stat)1 and Stat3 promotes the generation of IL-10- producing type 1 regulatory T (Tr1) cells that inhibit effector T cells. In addition, IL-27 also suppresses the development of pathogenic IL-17-producing CD4(+) T cells (T(H)17) cells suggesting that pharmacological manipulations of IL-27 signaling pathway could be exploited therapeutically in regulating tissue inflammation. Here, we review how IL-27 controls inflammation through the regulation of Tr1 and T(H)17 responses.
authors: Department of Pathology and Immunology, University of Geneva, Switzerland.
authors: Caroline
authors: C
authors: Pot
authors: Lionel
authors: L
authors: Apetoh
authors: Amit
authors: A
authors: Awasthi
authors: Vijay K
authors: VK
authors: Kuchroo
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D006801:Humans; D016753:Interleukin-10 / Q000096:biosynthesis* / Q000276:immunology; D007378:Interleukins / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D058504:Th17 Cells / Q000276:immunology*
chemical_list: D007378:Interleukins; D016753:Interleukin-10