title: Effect of various anticoagulant agents on large-volume leukocytapheresis using new Cellsorba CS-180S Filter.
abstract: We conducted a study to evaluate the effect of various anticoagulant agents on large-volume leukocytapheresis using the new Cellsorba CS-180S Filter filled with a changed solution of sodium pyrosulfite and sodium carbonate. We conducted the study on a total of 12 cases of rheumatoid arthritis. As the anticoagulant agents we used sodium citrate, nafamostat mesilate and low molecular weight heparin. The new Cellsorba CS-180S was safely used with the various blood anticoagulant agents. Also, through adjustment of the sodium citrate percentage to the blood flow volume, it is hypothesized that it is possible to increase the neutrophil removal rate.
authors: Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan. katsura@juntendo.ac.jp
authors: Katsura
authors: K
authors: Hohtatsu
authors: Ken
authors: K
authors: Yamaji
authors: Risa
authors: R
authors: Yamada
authors: Keisuke
authors: K
authors: Oda
authors: Michiaki
authors: M
authors: Kageyama
authors: Makio
authors: M
authors: Kusaoi
authors: Shin
authors: S
authors: Onuma
authors: Toshio
authors: T
authors: Kawamoto
authors: Kaoru
authors: K
authors: Sugimoto
authors: Fumio
authors: F
authors: Sekiya
authors: Takayuki
authors: T
authors: Kon
authors: Michihiro
authors: M
authors: Ogasawara
authors: Kazuo
authors: K
authors: Kempe
authors: Hiroshi
authors: H
authors: Tsuda
authors: Yoshinari
authors: Y
authors: Takasaki
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage*; D001172:Arthritis, Rheumatoid / Q000628:therapy; D001550:Benzamidines; D002254:Carbonates / Q000737:chemistry; D002951:Citrates / Q000008:administration & dosage*; D005374:Filtration / Q000295:instrumentation; D006146:Guanidines / Q000008:administration & dosage*; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage*; D006801:Humans; D007937:Leukapheresis / Q000295:instrumentation / Q000379:methods*; D009504:Neutrophils / Q000378:metabolism; D000077559:Sodium Citrate; D013447:Sulfites / Q000737:chemistry
chemical_list: D000925:Anticoagulants; D001550:Benzamidines; D002254:Carbonates; D002951:Citrates; D006146:Guanidines; D006495:Heparin, Low-Molecular-Weight; D013447:Sulfites; D000077559:Sodium Citrate; C005686:sodium carbonate; C005200:sodium metabisulfite; C032855:nafamostat