title: Rattle-type hollow CaWO4:Tb(3+)@SiO2 nanocapsules as carriers for drug delivery.
abstract: Rattle-type hollow nanocapsules are among of the most promising candidates as drug carriers owing to their huge inner space and multifunctional material combination. In this paper, rattle-type hollow CaWO(4):Tb(3+)@SiO(2) nanocapsules with a diameter of 100-110 nm and a wall thickness around 10 nm were fabricated. The hollow silica nanospheres were used as nano-reactors and the luminescent core of CaWO(4):Tb(3+) was post-filled into the nano-reactors by a vacuum nano-casting route combined with a Pechini-type sol-gel method. Subsequently, doxorubicin hydrochloride (DOX), a model of an anti-cancer drug, is loaded into the CaWO(4):Tb(3+)@SiO(2) nanocapsules and their cell cytotoxicity, cancer cell uptake and drug release behavior are investigated in vitro. The prepared multifunctional inorganic nanocapsules show a loading capacity for DOX as high as 124 mg g(-1) and sustained-release properties. The release profile of the drug from DOX-loaded nanocapsules can last over five days. Besides, the blank CaWO(4):Tb(3+)@SiO(2) shows very low cytotoxicity against cancer cell lines (HeLa cell) while the DOX-loaded nanocapsules exhibit relatively high efficiency for killing of HeLa cells. The rapid cancer cell uptake process is observed by confocal laser scanning microscopy. The results indicate that a rattle-type hollow CaWO(4):Tb(3+)@SiO(2) nanocapsule has the potential to be used as drug carrier in therapy. Moreover, it is possible to extend the synthetic strategy in this study to other rattle-type multifunctional composites to meet various demands.
authors: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, PR China.
authors: Xuefeng
authors: X
authors: Zhai
authors: Min
authors: M
authors: Yu
authors: Ziyong
authors: Z
authors: Cheng
authors: Zhiyao
authors: Z
authors: Hou
authors: Ping'an
authors: P
authors: Ma
authors: Dongmei
authors: D
authors: Yang
authors: Xiaojiao
authors: X
authors: Kang
authors: Yunlu
authors: Y
authors: Dai
authors: Dong
authors: D
authors: Wang
authors: Jun
authors: J
authors: Lin
mesh_terms: D017610:Calcium Compounds / Q000737:chemistry*; D002470:Cell Survival; D004317:Doxorubicin / Q000633:toxicity; D016503:Drug Delivery Systems; D006367:HeLa Cells; D006801:Humans; D018613:Microscopy, Confocal; D053769:Nanocapsules / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D013725:Terbium / Q000737:chemistry*; D017973:Tungsten Compounds / Q000737:chemistry*
chemical_list: D017610:Calcium Compounds; D053769:Nanocapsules; D017973:Tungsten Compounds; D013725:Terbium; D012822:Silicon Dioxide; D004317:Doxorubicin; C018858:calcium tungstate