title: Vascular endothelial growth factor gene polymorphisms in spontaneously aborted fetuses.
abstract: OBJECTIVE
  The VEGF-1154G>A polymorphism has been reported to be a genetic risk factor for recurrent spontaneous abortion in various studies; however, these studies have focused on genetic analyses of pregnant women rather than aborted fetuses. To evaluate and confirm the association between the VEGF-1154G>A polymorphism and spontaneous abortion, we focused on the relationship between four polymorphisms in the VEGF gene (-2578C>A, -1154G>A, -634G>C, and 936C>T) and spontaneously aborted fetuses (SAFs).
  
  
  METHODS
  The subjects included 118 SAFs at <20 weeks gestation and 380 normal controls consisting of children and adults. The polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism analysis.
  
  
  RESULTS
  Spontaneously aborted fetuses exhibited significantly different frequencies of the -2578CA+AA/-634CC and -1154GA+AA/-634CC combined genotypes compared with control subjects. The frequency of the -2578A/-1154A/-634C/936C haplotype was significantly higher in SAFs.
  
  
  CONCLUSIONS
  VEGF genes -2578CA+AA/-634CC and -1154GA+AA/-634CC in the fetus are possible risk factors for spontaneous abortion.
authors: Institute for Clinical Research, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.
authors: Young Joo
authors: YJ
authors: Jeon
authors: Ji Hyang
authors: JH
authors: Kim
authors: HyungChul
authors: H
authors: Rah
authors: Su Yeoun
authors: SY
authors: Kim
authors: Tae Ki
authors: TK
authors: Yoon
authors: Dong Hee
authors: DH
authors: Choi
authors: Sun Hee
authors: SH
authors: Cha
authors: Sung Han
authors: SH
authors: Shim
authors: Nam Keun
authors: NK
authors: Kim
mesh_terms: D037881:Aborted Fetus; D000022:Abortion, Spontaneous / Q000235:genetics*; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D011247:Pregnancy; D012307:Risk Factors; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: D042461:Vascular Endothelial Growth Factor A