title: Independent association of joint space narrowing and osteophyte formation at the knee with health-related quality of life in Japan: a cross-sectional study.
abstract: OBJECTIVE
  To clarify the individual associations of joint space narrowing (JSN) and osteophytosis at the knee with quality of life (QOL) in Japanese men and women using a large-scale population-based cohort from the Research on Osteoarthritis Against Disability (ROAD) study.
  
  
  METHODS
  The associations of minimum joint space width (JSW) and osteophyte area in the medial compartment of the knee with QOL parameters, such as the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), were examined. Minimum JSW and osteophyte area in the medial compartment of the knee were measured using a computer-aided system for the diagnosis of knee osteoarthritis.
  
  
  RESULTS
  Of the 3,040 participants in the ROAD study, the present study included 2,039 participants age 40 years or older who completed the questionnaires (741 men and 1,298 women with a mean ± SD age of 68.6 ± 10.9 years). Multiple regression analysis after adjustment for age and body mass index showed that minimum JSW was significantly associated with scores on the pain domains of the WOMAC in men and women, while osteophyte area was significantly associated with scores on the physical function domains of the WOMAC in men and women.
  
  
  CONCLUSIONS
  The findings of this cross-sectional study using a large-scale population from the ROAD study indicate that JSN and osteophytosis are independently associated with QOL.
authors: Department of Clinical Motor System Medicine, 22nd Century Medical and Research Center, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan. murakis-ort@h.u-tokyo.ac.jp
authors: Shigeyuki
authors: S
authors: Muraki
authors: Hiroyuki
authors: H
authors: Oka
authors: Toru
authors: T
authors: Akune
authors: Yoshio
authors: Y
authors: En-yo
authors: Munehito
authors: M
authors: Yoshida
authors: Takao
authors: T
authors: Suzuki
authors: Hideyo
authors: H
authors: Yoshida
authors: Hideaki
authors: H
authors: Ishibashi
authors: Fumiaki
authors: F
authors: Tokimura
authors: Seizo
authors: S
authors: Yamamoto
authors: Kozo
authors: K
authors: Nakamura
authors: Hiroshi
authors: H
authors: Kawaguchi
authors: Noriko
authors: N
authors: Yoshimura
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003936:Diagnosis, Computer-Assisted; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007719:Knee Joint / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000208:ethnology*; D054850:Osteophyte / Q000000981:diagnostic imaging*; D011788:Quality of Life; D011859:Radiography; D012044:Regression Analysis