title: Synthesis of quinolin-2-one alkaloid derivatives and their inhibitory activities against HIV-1 reverse transcriptase.
abstract: Based on an established common pharmacophore of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNTTIs), a series of quinolin-2-one derivatives were synthesized and assayed for their in vitro activities against HIV-1 reverse transcriptase (RT) for the first time. Some of the tested compounds were active against HIV-1 RT. Compounds 4a2 and 4d2 showed inhibitory activities with IC(50) values of 0.21 and 0.15 mM, respectively, with a mode of interaction with RT residues of the allosteric pocket similar to that of efavirenz.
authors: National Research Center of Engineering Technology For Utilization of Functional Ingredients From Botanicals, College of Horticulture and Landscape Architecture, Hunan Agricultural University, Changsha 410128, Hunan, China. picheng55@126.com
authors: Pi
authors: P
authors: Cheng
authors: Qiong
authors: Q
authors: Gu
authors: Wei
authors: W
authors: Liu
authors: Jian-Feng
authors: JF
authors: Zou
authors: Yang-Yong
authors: YY
authors: Ou
authors: Zhong-Yong
authors: ZY
authors: Luo
authors: Jian-Guo
authors: JG
authors: Zeng
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D000495:Allosteric Site; D020816:Amino Acid Motifs; D003198:Computer Simulation; D057075:Enzyme Assays; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D015497:HIV-1 / Q000201:enzymology*; D057927:Hydrophobic and Hydrophilic Interactions; D008958:Models, Molecular; D008968:Molecular Conformation; D011485:Protein Binding; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000470:Alkaloids; D015363:Quinolones; D054303:HIV Reverse Transcriptase