title: Consensus statement on the diagnosis, management, and treatment of angioedema mediated by bradykinin. Part I. Classification, epidemiology, pathophysiology, genetics, clinical symptoms, and diagnosis.
abstract: BACKGROUND
  There are no Spanish guidelines or consensus statement on bradykinin-induced angioedema.
  
  
  OBJECTIVE
  To review the pathophysiology, genetics, and clinical symptoms of the different types of bradykinin-induced angioedema and to draft a consensus statement in light of currently available scientific evidence and the experience of experts. This statement will serve as a guideline to health professionals.
  
  
  METHODS
  The consensus was led by the Spanish Study Group on Bradykinin-Induced Angioedema (SGBA), a working group of the Spanish Society of Allergology and Clinical Immunology. A review was conducted of scientific papers on different types of bradykinin-induced angioedema (hereditary and acquired angioedema due to C1 inhibitor deficiency, hereditary angioedema related to estrogens, angioedema induced by angiotensin-converting enzyme inhibitors). Several discussion meetings of the SGBA were held in Madrid to reach the consensus.
  
  
  RESULTS
  The pathophysiology, genetics, and clinical symptoms of the different types of angioedema are reviewed. Diagnostic approaches are discussed and the consensus reached is described.
  
  
  CONCLUSIONS
  A review of bradykinin-induced angioedema and a consensus on diagnosis are presented.
authors: Servicio de Alergia, Hospital La Paz Health Research Institute (IdiPaz), Madrid, Spain. tcaballero.hulp@salud.madrid.org
authors: T
authors: T
authors: Caballero
authors: M L
authors: ML
authors: Baeza
authors: R
authors: R
authors: Cabañas
authors: A
authors: A
authors: Campos
authors: S
authors: S
authors: Cimbollek
authors: C
authors: C
authors: Gómez-Traseira
authors: T
authors: T
authors: González-Quevedo
authors: M
authors: M
authors: Guilarte
authors: G J
authors: GJ
authors: Jurado-Palomo
authors: J I
authors: JI
authors: Larco
authors: M C
authors: MC
authors: López-Serrano
authors: M
authors: M
authors: López-Trascasa
authors: C
authors: C
authors: Marcos
authors: J M
authors: JM
authors: Muñoz-Caro
authors: M
authors: M
authors: Pedrosa
authors: N
authors: N
authors: Prior
authors: M
authors: M
authors: Rubio
authors: A
authors: A
authors: Sala-Cunill
mesh_terms: D000799:Angioedema / Q000145:classification; D001920:Bradykinin / Q000009:adverse effects* / Q000627:therapeutic use; D003329:Coronary Vasospasm / Q000188:drug therapy*; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology*; D004632:Emergency Medical Services; D019317:Evidence-Based Medicine; D005104:Expert Testimony; D006801:Humans; D017410:Practice Guidelines as Topic; D012307:Risk Factors; D013030:Spain; D014665:Vasodilator Agents / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D014665:Vasodilator Agents; D001920:Bradykinin