title: Synthesis and pharmacological evaluation of some quinoline derivatives as potential cognition enhancers.
abstract: The present paper describes the synthesis of a series of substituted 6-amino (1a-c) and 8-aminoquinoline derivatives (2b-c) and the evaluation of their ability to prevent the memory decline using a behavioural model, i.e. the elevated plus maze test. The effect of the candidate drugs on the activity of acetylcholinesterase was studied using the enzyme source from the mouse brain. The structures of the synthesized compounds were confirmed by UV, IR, 1H-NMR and elemental analysis. The 6-aminoquinoline derivative [6-(4-pyridyl)methylaminoquinoline] (1c) oxalate showed maximum % retention (50% at 5 mg/kg and 75% at 10 mg/kg) in the elevated plus maze test and maximum % inhibition (71% at 25 microM) of AChE on biochemical evaluation.
authors: University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India. ppvohra28in@yahoo.co.in
authors: Poonam
authors: P
authors: Piplani
authors: Anita
authors: A
authors: Rani
authors: Ruchika
authors: R
authors: Saihgal
authors: Meenakshi
authors: M
authors: Sharma
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000447:Aldehydes / Q000737:chemistry; D000647:Amnesia / Q000188:drug therapy / Q000523:psychology; D000818:Animals; D001007:Anxiety / Q000188:drug therapy / Q000523:psychology; D001923:Brain Chemistry / Q000187:drug effects; D003071:Cognition / Q000187:drug effects*; D005260:Female; D007202:Indicators and Reagents; D007274:Injections, Intraperitoneal; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D009419:Nerve Tissue Proteins / Q000096:biosynthesis; D018697:Nootropic Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics* / Q000494:pharmacology*; D011804:Quinolines / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D012015:Reference Standards; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship
chemical_list: D000447:Aldehydes; D007202:Indicators and Reagents; D009419:Nerve Tissue Proteins; D018697:Nootropic Agents; D011804:Quinolines; D000110:Acetylcholinesterase