title: Allograft bone matrix versus synthetic bone graft substitutes.
abstract: Autologous bone is used very often in the treatment of fresh fractures, delayed unions and non-unions. Alternatives have included allografts and in recent years also demineralized bone matrix. The growing availability of good synthetic bone grafts and their advantages in safety and avoiding donor-site morbidity are the reasons that these products are being used more and more. There are on the market a wide variety of substitutes with different capabilities. Nevertheless autologous bone graft is still considered as the gold standard and will be discussed here in that context. Osteoconductive, osteogenic and osteoinductive products will also be classified and their advantages and disadvantages described.
authors: Theresienkrankenhaus Mannheim, Department of Trauma and Orthopaedic Surgery, University of Heidelberg, Germany. g.zimmermann@theresienkrankenhaus.de
authors: Gerald
authors: G
authors: Zimmermann
authors: Arash
authors: A
authors: Moghaddam
mesh_terms: D001672:Biocompatible Materials; D001843:Bone Cements / Q000627:therapeutic use*; D001857:Bone Matrix / Q000637:transplantation*; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use; D001861:Bone Regeneration / Q000187:drug effects / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000379:methods* / Q000639:trends; D002130:Calcium Phosphates / Q000627:therapeutic use; D002516:Ceramics / Q000627:therapeutic use; D017886:Durapatite / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010012:Osteogenesis / Q000187:drug effects; D013997:Time Factors; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D019485:Bone Morphogenetic Proteins; D018786:Bone Substitutes; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate; D017886:Durapatite