title: Evidence for the use of l-methylfolate combined with antidepressants in MDD.
abstract: Helping patients with major depressive disorder achieve symptom-free remission with antidepressant therapy remains challenging. In this activity, 3 investigators discuss the results of a 2-trial, multicenter, randomized, double-blind, placebo-controlled study of adjunctive l-methylfolate, the bioavailable form of folate, in patients who had inadequately responded to an SSRI. The efficacy of doses of 7.5 mg/d versus 15 mg/d is examined, and the safety and tolerability of l-methylfolate are compared with those of other adjunctive treatments. Different types of folate are explained, and the characteristics of patients who might benefit from adjunctive l-methylfolate are proposed.
authors: From the Department of Psychiatry, Harvard Medical School and Massachusetts General Hospital, Boston, USA.
authors: Maurizio
authors: M
authors: Fava
authors: Richard C
authors: RC
authors: Shelton
authors: John M
authors: JM
authors: Zajecka
mesh_terms: D000928:Antidepressive Agents / Q000008:administration & dosage* / Q000737:chemistry; D003865:Major Depressive Disorder / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005492:Folic Acid / Q000008:administration & dosage* / Q000737:chemistry; D006801:Humans; D015337:Multicenter Studies as Topic; D018579:Patient Selection; D016032:Randomized Controlled Trials as Topic
chemical_list: D000928:Antidepressive Agents; D005492:Folic Acid