title: Elimination of adult-born neurons in the olfactory bulb is promoted during the postprandial period.
abstract: Granule cells (GCs) in the mouse olfactory bulb (OB) continue to be generated in adulthood, with nearly half incorporated and the remainder eliminated. Here, we show that elimination of adult-born GCs is promoted during a short time window in the postprandial period. Under restricted feeding, the number of apoptotic GCs specifically increased within a few hours after the start of feeding. This enhanced GC apoptosis occurred in association with postprandial behaviors that included grooming, resting, and sleeping, and was particularly correlated with the length of postprandial sleep. Further, deprivation of olfactory sensory experience in the local OB area potentiated the extent of GC elimination in that area during the postprandial period. Sensory experience-dependent enhancement of GC elimination also occurred during postprandial period under natural feeding condition. These results suggest that extensive structural reorganization of bulbar circuitry occurs during the postprandial period, reflecting sensory experience during preceding waking period.
authors: Department of Physiology, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan.
authors: Takeshi K
authors: TK
authors: Yokoyama
authors: Daisuke
authors: D
authors: Mochimaru
authors: Koshi
authors: K
authors: Murata
authors: Hiroyuki
authors: H
authors: Manabe
authors: Ko
authors: K
authors: Kobayakawa
authors: Reiko
authors: R
authors: Kobayakawa
authors: Hitoshi
authors: H
authors: Sakano
authors: Kensaku
authors: K
authors: Mori
authors: Masahiro
authors: M
authors: Yamaguchi
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D017209:Apoptosis / Q000502:physiology*; D001973:Bromodeoxyuridine / Q000378:metabolism; D053148:Caspase 3 / Q000378:metabolism; D002452:Cell Count / Q000379:methods; D002940:Circadian Rhythm; D000089622:Doublecortin Domain Proteins; D004327:Drinking Behavior / Q000502:physiology; D005106:Exploratory Behavior / Q000502:physiology; D005247:Feeding Behavior; D005508:Food Deprivation / Q000502:physiology; D006120:Grooming; D006624:Hippocampus / Q000166:cytology / Q000254:growth & development; D020287:In Situ Nick-End Labeling / Q000379:methods; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008954:Models, Biological; D055495:Neurogenesis / Q000502:physiology*; D009479:Neuropeptides / Q000378:metabolism; D009812:Odorants; D009830:Olfactory Bulb / Q000166:cytology* / Q000293:injuries; D018034:Olfactory Receptor Neurons / Q000502:physiology*; D019518:Postprandial Period / Q000502:physiology; D012683:Sensory Deprivation / Q000502:physiology; D013997:Time Factors
chemical_list: D000089622:Doublecortin Domain Proteins; D008869:Microtubule-Associated Proteins; D009479:Neuropeptides; D053148:Caspase 3; D001973:Bromodeoxyuridine