title: In Vitro and In Vivo Effects of Natural Putative Secretagogues of Glucagon-Like Peptide-1 (GLP-1).
abstract: Glucagon-like peptide-1 (GLP-1) is an intestinal hormone with well-established glucose-lowering activity. The in vitro and in vivo actions of natural putative secretagogues of GLP-1 were investigated. The acute GLP-1 releasing activity of olive leaf extract (OLE), glutamine (GLN), alpha casein (ACAS), beta casein (BCAS) and chlorogenic acid (CGA) were assessed in STC-1 cells and C57BL/6 mice. All compounds except ACAS significantly increased acute in vitro GLP-1 secretion (66-386%; P<0.05-0.001). Oral gavage of OLE and GLN modestly increased plasma GLP-1 concentrations (48% and 41%, respectively), but did not lower glycaemic excursions. OLE and GLN are potent stimulators of GLP-1 secretion both in vitro and in vivo and chronic studies should assess their suitability as nutritional therapies for type 2 diabetes.
authors: School of Biological Sciences, Queen's University Belfast, BT9 5AG, Northern Ireland, United Kingdom.
authors: Eamon P
authors: EP
authors: Rafferty
authors: Alastair R
authors: AR
authors: Wylie
authors: Chris T
authors: CT
authors: Elliott
authors: Olivier P
authors: OP
authors: Chevallier
authors: David J
authors: DJ
authors: Grieve
authors: Brian D
authors: BD
authors: Green