title: Comparison of injuring effects of vesicant, irritant, and nonvesicant anticancer drugs on endothelial cells.
abstract: Anticancer drugs are classified as vesicant, irritant, and nonvesicant drugs on the basis of frequency of their vascular disorder. In this study, we compared the injuring effects of three typical anticancer drugs of each class on porcine aorta endothelial cells (PAECs). The concentration inducing 50% cell viability inhibition was lower in the order of vesicant, irritant, and nonvesicant drugs. These results suggest that injuring effects of anticancer drugs on PAECs may be relevant as an indicator of frequency of their vascular disorder, and that this experimental model may be useful for the study of vascular disorder.
authors: Department of Pharmacy, Kyushu University Hospital, Higashi-ku, Fukuoka 812-8582, Japan.
authors: Takaaki
authors: T
authors: Yamada
authors: Nobuaki
authors: N
authors: Egashira
authors: Maiko
authors: M
authors: Imuta
authors: Ayami
authors: A
authors: Bando
authors: Takahisa
authors: T
authors: Yano
authors: Mami
authors: M
authors: Saito
authors: Ryozo
authors: R
authors: Oishi
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000633:toxicity*; D001011:Aorta / Q000166:cytology; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D042783:Endothelial Cells / Q000187:drug effects*; D007509:Irritants / Q000633:toxicity*; D013552:Swine
chemical_list: D016588:Anticarcinogenic Agents; D007509:Irritants