title: Backbone resonances assignment of 19 kDa CD1 domain of human mitotic checkpoint serine/threonine-protein kinase, Bub1.
abstract: Bub1 is an evolutionarily conserved mitotic checkpoint control protein that is present in diverse organisms including yeast and humans. Bub1 is a serine/threonine protein kinase and is required for recruitment of Mad1, Mad2, Bub3, and CENP-E to kinetochores (Sharp-Baker and Chen in J Cell Biol 153:1239-1250, 2001). The evolutionarily conserved amino acid region in the N-terminus has been called as the CD1 domain. To clarify the action mechanism of Bub1 in controlling check point signals, we initiated an NMR structure determination of the Bub1 CD1 domain. Here, we report the sequence-specific backbone resonance assignments of CD1 domain of human Bub1 (hBub1CD1).
authors: College of Pharmacy, Gachon University of Medicine and Science, 534-2 Yeonsu 3-dong, Yeonsu-gu, Incheon 406-799, Korea.
authors: Sung Jean
authors: SJ
authors: Park
authors: Hyun-Hwi
authors: HH
authors: Kim
authors: Yu-Sun
authors: YS
authors: Jung
authors: Su-Jin
authors: SJ
authors: Kang
authors: Hae-Kap
authors: HK
authors: Cheong
authors: Hyun-Kyu
authors: HK
authors: Song
authors: Bong-Jin
authors: BJ
authors: Lee
mesh_terms: D017124:Conserved Sequence; D006801:Humans; D008970:Molecular Weight; D019906:Nuclear Magnetic Resonance, Biomolecular; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry*; D017434:Protein Structure, Tertiary
chemical_list: C584277:BUB1 protein, human; C090464:Bub1 spindle checkpoint protein; D017346:Protein Serine-Threonine Kinases