title: Tolerogenic dendritic cells and rheumatoid arthritis: current status and perspectives.
abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the influxation of synovia and synovial compartments with immune cells including dendritic cells (DCs). DCs that induce autoimmune tolerance are called tolerogenic DCs (tolDCs). As a promising immunotherapeutic strategy for RA, tolDCs have received increasing attention. In this review, we first introduce the significant role of tolDCs in autoimmune regulation and then describe the manipulation strategies to generate tolDCs; next, we summarize recent progress in the experimental application of tolDCs for RA therapy, and finally we discuss the perspectives of tolerogenic vaccination for the treatment for RA in clinic.
authors: Shandong University, Jinan, Shandong, China.
authors: Yunpeng
authors: Y
authors: Zhao
authors: Aijun
authors: A
authors: Zhang
authors: Hongxia
authors: H
authors: Du
authors: Shuya
authors: S
authors: Guo
authors: Bin
authors: B
authors: Ning
authors: Shangyou
authors: S
authors: Yang
mesh_terms: D001172:Arthritis, Rheumatoid / Q000276:immunology*; D015551:Autoimmunity / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology