title: Physical illnesses, developmental risk factors and psychiatric diagnoses among subjects at risk of psychosis.
abstract: BACKGROUND
  Subjects with psychoses have significantly increased rates of physical illnesses, but the nature of the relationship remains largely unknown.
  
  
  METHODS
  The present study is part of the European Prediction of Psychosis Study (EPOS). Data were collected from 245 help-seeking individuals from six European centers (age 16-35) who met criteria for ultra-high risk of psychosis criteria. This paper seeks to investigate self-reported physical ill health and its associations with psychiatric symptoms and disorders, risk factors, and onset of psychosis during 48 months of follow-up.
  
  
  RESULTS
  In multivariate analysis, lifetime panic disorder (OR=2.43, 95%CI: 1.03-5.73), known complications during pregnancy and delivery (OR=2.81, 95%CI: 1.10-7.15), female gender (OR=2.88, 95%CI: 1.16-7.17), family history of psychosis (OR=3.08, 95%CI: 1.18-8.07), and having a relationship (OR=3.44, 95%CI: 1.33-8.94) were significantly associated with self-reported physician-diagnosed illness. In the Cox proportional hazard model we found no significant differences between those who had undergone a transition to psychosis and those who had not.
  
  
  CONCLUSIONS
  The physical health of patients defined to be at ultra-high risk of psychosis seems to be commonly impaired and associated with female gender, marital status, complications during pregnancy and birth, lifetime panic disorder, and genetic risk of psychosis.
authors: Department of Psychiatry, University of Turku, Turku University Central Hospital, Kunnallissairaalantie 20, 20700 Turku, Finland; Harjavalta Hospital, Satakunta Health District, Finland. jyrkor@utu.fi
authors: J
authors: J
authors: Korkeila
authors: R K R
authors: RK
authors: Salokangas
authors: M
authors: M
authors: Heinimaaa
authors: T
authors: T
authors: Svirskis
authors: T
authors: T
authors: Laine
authors: S
authors: S
authors: Ruhrmann
authors: H
authors: H
authors: von Reventlow
authors: G
authors: G
authors: Juckel
authors: D
authors: D
authors: Linszen
authors: M
authors: M
authors: Birchwood
authors: J
authors: J
authors: Klosterkötter
mesh_terms: D000293:Adolescent; D000328:Adult; D004194:Disease / Q000523:psychology; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D017533:Marital Status; D015999:Multivariate Analysis; D016584:Panic Disorder / Q000150:complications; D011247:Pregnancy; D011248:Pregnancy Complications / Q000523:psychology; D016016:Proportional Hazards Models; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000209:etiology* / Q000235:genetics; D012307:Risk Factors; D012737:Sex Factors; D055815:Young Adult