title: Heart arachidonic acid is uniquely sensitive to dietary arachidonic acid and docosahexaenoic acid content in domestic piglets.
abstract: This study determined the sensitivity of heart and brain arachidonic acid (ARA) and docosahexaenoic acid (DHA) to the dietary ARA level in a dose-response design with constant, high DHA in neonatal piglets. On day 3 of age, pigs were assigned to 1 of 6 dietary formulas varying in ARA/DHA as follows (% fatty acid, FA/FA): (A1) 0.1/1.0; (A2) 0.53/1.0; (A3-D3) 0.69/1.0; (A4) 1.1/1.0; (D2) 0.67/0.62; and (D1) 0.66/0.33. At necropsy (day 28) higher levels of dietary ARA were associated with increased heart and liver ARA, while brain ARA remained unaffected. Dietary ARA had no effect on tissue DHA accretion. Heart was particularly sensitive, with pigs in the intermediate groups having different ARA (A2, 18.6±0.7%; A3, 19.4±1.0%) and a 0.17% increase in dietary ARA resulted in a 0.84% increase in heart ARA. Further investigations are warranted to determine the clinical significance of heart ARA status in developing neonates.
authors: Division of Nutritional Sciences, B38 Savage Hall, Cornell University, Ithaca, NY 14853, USA.
authors: Cynthia
authors: C
authors: Tyburczy
authors: Kumar S D
authors: KS
authors: Kothapalli
authors: Woo Jung
authors: WJ
authors: Park
authors: Bryant S
authors: BS
authors: Blank
authors: Kathryn L
authors: KL
authors: Bradford
authors: J Paul
authors: JP
authors: Zimmer
authors: Christopher M
authors: CM
authors: Butt
authors: Norman
authors: N
authors: Salem
authors: J Thomas
authors: JT
authors: Brenna
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D016718:Arachidonic Acid / Q000008:administration & dosage / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D004041:Dietary Fats / Q000008:administration & dosage / Q000378:metabolism*; D004281:Docosahexaenoic Acids / Q000008:administration & dosage / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D005526:Food, Formulated; D016014:Linear Models; D008099:Liver / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D011897:Random Allocation; D012160:Retina / Q000378:metabolism; D034421:Sus scrofa / Q000254:growth & development / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid