title: Nitrite exhaled breath condensate study in patients undergoing cardiopulmonary bypass cardiac surgery.
abstract: BACKGROUND
  There is a relative lack of studies on postoperative changes in nitrite (NO2 - ) concentrations, a marker of injury, following cardiac surgery. In this context, investigations on how exhaled NO concentrations vary in the postoperative period of cardiac surgery will certainly contribute to new clinical findings.
  
  
  OBJECTIVE
  The objective of this study was to compare the EBC NO levels in both the pre and postoperative (24 hours) periods of cardiac surgery.
  
  
  METHODS
  Twenty - eight individuals were divided into three groups: 1) control, 2) coronary artery bypass grafting, and 3) valve surgery. The nitrite (NO2 - ) levels were measured by chemiluminescence in blood samples and exhaled breath condensate (EBC). Data were analyzed by the Mann - Whitney and Wilcoxon tests.
  
  
  RESULTS
  1) Preoperatively, the EBC NO2 - levels from groups 2 and 3 patients were higher than control individuals; 2) The postoperative (24 hours) NO2 - levels in the EBC from group 3 patients were lower compared with preoperative values; 3) The NO2 - levels in the plasma from group 2 patients were lower in the preoperative compared with the postoperative (24h) values and; 4) Preoperatively, there was no difference between groups 2 and 3 in terms of plasma NO2 - concentrations.
  
  
  CONCLUSIONS
  These data suggest that NO measurement in EBC is feasible in cardiac surgery patients.
authors: Programa de Aprimoramento em Fisioterapia Divisão de Cirurgia Cardiotorácica, Hospital das Clínicas de Ribeirão Preto, FMRP, USP.
authors: Viviane Dos Santos
authors: Vdos S
authors: Augusto
authors: Graziela Saraiva
authors: GS
authors: Reis
authors: Verena Kise
authors: VK
authors: Capellini
authors: Andrea Carla
authors: AC
authors: Celotto
authors: Alfredo José
authors: AJ
authors: Rodrigues
authors: Paulo Roberto Barbosa
authors: PR
authors: Evora
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D001944:Breath Tests / Q000379:methods*; D016022:Case-Control Studies; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D045853:Exhalation; D005260:Female; D006351:Heart Valves / Q000601:surgery*; D006801:Humans; D055370:Lung Injury / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009573:Nitrites / Q000032:analysis*; D011184:Postoperative Period; D057234:Preoperative Period; D011446:Prospective Studies; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; D009573:Nitrites