title: Ras, ROS and proteotoxic stress: a delicate balance.
abstract: Ras-deregulated cells require reactive oxygen species for proliferation. They survive the resultant proteotoxic stress by maintaining sufficient levels of reduced glutathione and optimally functioning stress response machinery. In this issue of Cancer Cell, De Raedt et al. identify a novel strategy that utilizes this dependency to cause cell death.
authors: Urologic Oncology Branch, National Cancer Institute, Center for Cancer Research, Bethesda, MD 20892, USA.
authors: Wanping
authors: W
authors: Xu
authors: Jane
authors: J
authors: Trepel
authors: Len
authors: L
authors: Neckers