title: Synthesis of Diarylpyrazoles Containing a Phenylsulphone or Carbonitrile Moiety and their Chalcones as Possible Anti-Inflammatory Agents.
abstract: A series of chalcone-based diarylpyrazoles containing a phenylsulphone or carbonitrile moiety was synthesized. Thus, 3-acetylpyrazoles 6a-c and 10a-c were used as useful substrates in facile synthesis of functional pyrazoles 7a-f and 11a-f, respectively. The anti-inflammatory activity and ulcerogenic effect were evaluated and some of the obtained products possessed a significant anti-inflammatory activity. 1-[1-(3-Methylphenyl)-5-phenyl-4-(phenylsulfonyl)-1H-pyrazol-3-yl]ethanone (6b) showed a high activity when compared with indomethacin as reference drug with lower gastrointestinal (GI) profile. Furthermore, molecular docking studies were performed in order to rationalize the obtained biological results.
authors: Department of Chemistry, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt.
authors: Ekhlass
authors: E
authors: Nassar
authors: Hatem A
authors: HA
authors: Abdel-Aziz
authors: Hany S
authors: HS
authors: Ibrahim
authors: Ahmed M
authors: AM
authors: Mansour