title: When T cells run out of breath: the HIF-1α story.
abstract: In this issue, Dang et al. (2011) report a role for the hypoxia-induced transcription factor HIF-1α in regulating the differentiation of T cell subsets that impact both inflammation and its resolution. Their findings illustrate how metabolic signals can alter the balance between inflammation and tolerance and present a potential therapeutic opportunity for the treatment of diseases associated with chronic inflammation.
authors: Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors: Katherine
authors: K
authors: Nutsch
authors: Chyi
authors: C
authors: Hsieh