title: Characterization of cyclofructan-based chiral stationary phases by linear free energy relationship.
abstract: Cyclofructans (CFs), a new class of chiral selectors, have been recently introduced for application in liquid chromatography and capillary electrophoresis. So far, derivatized CFs have performed interesting separation possibilities for a variety of compounds. The current work is focused on characterization of three different CF-based chiral stationary phases (CF-based CSPs), i.e. isopropyl carbamate cyclofructan 6 (IP-CF6), R-naphthylethyl carbamate cyclofructan 6 (RN-CF6) and dimethylphenyl carbamate cyclofructan 7 (DMP-CF7). The linear free energy relationship (LFER) model was used to reveal the dominant interactions participating in the complex retention mechanism. A set of 44 different test solutes, with known solvation parameters, was used to determine the regression coefficients of the LFER equation under two mobile-phase compositions in normal separation mode. The LFER results showed that hydrogen bond acidity, hydrophobicity and dipolarity/polarizibility mostly affect the retention and separation process on the CF-based columns in the studied separation systems.
authors: Department of Analytical Chemistry, Faculty of Science, Charles University in Prague, Prague, Czech Republic.
authors: Lucie
authors: L
authors: Janečková
authors: Květa
authors: K
authors: Kalíková
authors: Jiří
authors: J
authors: Vozka
authors: Daniel W
authors: DW
authors: Armstrong
authors: Zuzana
authors: Z
authors: Bosáková
authors: Eva
authors: E
authors: Tesařová