title: Highly effective copper-catalyzed decarboxylative coupling of aryl halides with alkynyl carboxylic acids.
abstract: We have developed a highly effective copper-catalyzed decarboxylative coupling of alkynylcarboxylic acids with various aryl and alkyl halides at 2 mol% loading of copper. This method is simple, economical and practical for the synthesis of disubstituted alkyne compounds.
authors: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P. R. China.
authors: Xiaoming
authors: X
authors: Qu
authors: Tingyi
authors: T
authors: Li
authors: Peng
authors: P
authors: Sun
authors: Yan
authors: Y
authors: Zhu
authors: Hailong
authors: H
authors: Yang
authors: Jincheng
authors: J
authors: Mao
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003653:Decarboxylation; D006219:Halogens / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure
chemical_list: D000480:Alkynes; D002264:Carboxylic Acids; D006219:Halogens; D008024:Ligands; D003300:Copper