title: Two new cytotoxic phenylallylflavanones from Mexican propolis.
abstract: Two new phenylallylflavanones, (2R,3R)-6-[1-(4'-hydroxy-3'-methoxyphenyl)prop-2-en-1-yl]pinobanksin (1) and (2R,3R)-6-[1-(4'-hydroxy-3'-methoxyphenyl)prop-2-en-1-yl]pinobanksin 3-acetate (2) were isolated from a methanolic extract of Mexican propolis. Their structures were elucidated with spectroscopic analysis. Both compounds (1, 2) exhibited preferential cytotoxic activity against PANC-1 human pancreatic cancer cells in a nutrient-deprived medium with the concentration at which 50% cells died preferentially in NDM (PC₅₀) values of 17.9 μM and 9.1 μM, respectively.
authors: Institute of Natural Medicine, University of Toyama, Japan.
authors: Feng
authors: F
authors: Li
authors: Yu-Min
authors: YM
authors: He
authors: Suresh
authors: S
authors: Awale
authors: Shigetoshi
authors: S
authors: Kadota
authors: Yasuhiro
authors: Y
authors: Tezuka
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D044950:Flavanones / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008800:Mexico; D008968:Molecular Conformation; D011429:Propolis / Q000737:chemistry*
chemical_list: C568913:(2R,3R)-6-(1-(4'-hydroxy-3'-methoxyphenyl)prop-2-en-1-yl)pinobanksin; C568914:(2R,3R)-6-(1-(4'-hydroxy-3'-methoxyphenyl)prop-2-en-1-yl)pinobanksin 3-acetate; D000970:Antineoplastic Agents; D044950:Flavanones; D011429:Propolis