title: [Main pharmacokinetic parameters of p-tyrosol after intravenous injection in rats. Part III: Distribution of p-tyrosol in rat].
abstract: Distribution of p-tyrosol in organism was studied in rats after a single intravenous administration in a dose of 200 mg/kg. It was shown that p-tyrosol rapidly penetrates into well perfused organs (brain, heart, kidneys). The maximum concentration ofp-tyrosol in these organs was determined in 1 minute after administration, and the mean distribution constant was within 0.8-1.11. The albumin bound fraction ofp-tyrozol amounted to 0.26-0.30.
authors: G A
authors: GA
authors: Chernyshova
authors: M B
authors: MB
authors: Plotnikov
authors: V I
authors: VI
authors: Smol'iakova
authors: E A
authors: EA
authors: Krasnov
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D001682:Biological Availability; D001711:Biotransformation; D001923:Brain Chemistry; D006207:Half-Life; D007275:Injections, Intravenous; D007668:Kidney / Q000098:blood supply / Q000737:chemistry*; D009206:Myocardium / Q000737:chemistry*; D010626:Phenylethyl Alcohol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D011485:Protein Binding; D051381:Rats; D012709:Serum Albumin / Q000378:metabolism; D013050:Spectrometry, Fluorescence; D014018:Tissue Distribution
chemical_list: D000889:Anti-Arrhythmia Agents; D012709:Serum Albumin; C011867:4-hydroxyphenylethanol; D010626:Phenylethyl Alcohol