title: The OMERACT Psoriatic Arthritis Magnetic Resonance Imaging Score (PsAMRIS) is reliable and sensitive to change: results from an OMERACT workshop.
abstract: OBJECTIVE
  The aim of this multireader exercise was to assess the reliability and sensitivity to change of the psoriatic arthritis magnetic resonance imaging score (PsAMRIS) in PsA patients followed for 1 year.
  
  
  METHODS
  MRI was acquired from 12 patients with PsA before initiation of treatment and after 12 months. MR images were scored according to PsAMRIS (for synovitis, tenosynovitis, periarticular inflammation, bone marrow edema, bone erosion, and bone proliferation) under standardized conditions, in unknown chronological order. Intraobserver/interobserver reliability was examined by intraclass correlation coefficients (ICC) and sensitivity to change by standardized response means (SRM).
  
  
  RESULTS
  The interobserver reliability of PsAMRIS was high for synovitis, tenosynovitis, periarticular inflammation, and bone edema status and change scores (interobserver ICC 0.87-0.97). The intraobserver reliability was moderate to high (ICC 0.60-0.98) for status and change scores, except for change in periarticular inflammation (ICC 0.33). PsAMRIS sensitivity to change was moderate for synovitis, tenosynovitis, and periarticular inflammation (SRM 0.5-0.8), while poor (SRM 0.1-0.3) for bone marrow edema, erosion, and bone proliferation. Rare occurrence and minimal change contributed to poor SRM and change-score ICC for bone parameters.
  
  
  CONCLUSIONS
  This multireader exercise, performed under standardized conditions, confirmed PsAMRIS to have high interobserver and intraobserver reliability for hand PsA. Measures of inflammation were sensitive to change, implying that PsAMRIS may be a valuable tool for monitoring change in inflammation during PsA clinical trials.
authors: Department of Rheumatology, Diakonhjemmet Hospital, Oslo,Norway. pernilleboyesen@gmail.com
authors: Pernille
authors: P
authors: Bøyesen
authors: Fiona M
authors: FM
authors: McQueen
authors: Frédérique
authors: F
authors: Gandjbakhch
authors: Siri
authors: S
authors: Lillegraven
authors: Laura
authors: L
authors: Coates
authors: Charlotte
authors: C
authors: Wiell
authors: Espen A
authors: EA
authors: Haavardsholm
authors: Philip G
authors: PG
authors: Conaghan
authors: Charles G
authors: CG
authors: Peterfy
authors: Paul
authors: P
authors: Bird
authors: Mikkel
authors: M
authors: Ostergaard
mesh_terms: D000328:Adult; D000368:Aged; D015535:Arthritis, Psoriatic / Q000175:diagnosis / Q000473:pathology*; D004493:Education / Q000592:standards; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000592:standards*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013585:Synovitis / Q000175:diagnosis / Q000473:pathology; D013717:Tenosynovitis / Q000175:diagnosis / Q000473:pathology