title: PGC1α gene Gly482Ser polymorphism predicts improved metabolic, inflammatory and vascular outcomes following bariatric surgery.
abstract: OBJECTIVE
  Bariatric surgery is currently employed as an effective approach to treat class III obesity and class II obesity with co-morbidities. Unfortunately, the general anthropometric and metabolic outcomes of the surgery are not homogeneous, and defining the eligibility criteria that allow for a more precise prediction of the outcomes of this invasive procedure will refine the selection of patients. Here we tested the hypothesis that the Gly482Ser polymorphism of the ppargc1a gene would predict different outcomes following bariatric surgery.
  
  
  METHODS
  Fifty-five patients (26 Gly/Gly and 29 Gly/Ser+Ser/Ser) selected for the Roux-en-Y gastric bypass according to the National Institutes of Health Consensus Statement criteria were followed up for 1 year, monitoring their anthropometric, metabolic and inflammatory parameters.
  
  
  RESULTS
  Patients with the Gly482Ser polymorphism had significantly improved reductions in the waist/hip ratio, fasting blood glucose, C-reactive protein, blood leukocyte count, serum interleukin-6 and intima-media thickness of the carotid artery, as compared with Gly/Gly patients.
  
  
  CONCLUSIONS
  Thus, the Gly482Ser polymorphism may predict a more favorable metabolic and inflammatory outcome for obese patients submitted to bariatric surgery, leading to a reduced atherosclerotic risk.
authors: Laboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, Brazil.
authors: S R
authors: SR
authors: Geloneze
authors: B
authors: B
authors: Geloneze
authors: J
authors: J
authors: Morari
authors: J R
authors: JR
authors: Matos-Souza
authors: M M
authors: MM
authors: Lima
authors: E A
authors: EA
authors: Chaim
authors: J C
authors: JC
authors: Pareja
authors: L A
authors: LA
authors: Velloso
mesh_terms: D000293:Adolescent; D000328:Adult; D001938:Brazil / Q000453:epidemiology; D002097:C-Reactive Protein / Q000235:genetics; D059168:Carotid Intima-Media Thickness; D015897:Comorbidity; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D015390:Gastric Bypass / Q000379:methods; D005998:Glycine; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000453:epidemiology / Q000235:genetics* / Q000601:surgery*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D012694:Serine; D016896:Treatment Outcome; D015431:Weight Loss; D055815:Young Adult
chemical_list: D015850:Interleukin-6; D012694:Serine; D002097:C-Reactive Protein; D005998:Glycine