title: Treatment duration of febrile urinary tract infections.
abstract: Although febrile urinary tract infections (UTIs) are relatively common in adults, data on optimal treatment duration are limited. Randomized controlled trials specifically addressing the elderly and patients with comorbidities have not been performed. This review highlights current available evidence. Premenopausal, non-pregnant women without comorbidities can be treated with a 5-7 day regimen of fluoroquinolones in countries with low levels of fluoroquinolone resistance, or, if proven susceptible, with 14 days of trimethoprim-sulfamethoxazole. Oral β-lactams are less effective compared with fluoroquinolones and trimethoprim-sulfamethoxazole. In men with mild to moderate febrile UTI, a 2-week regimen of an oral fluoroquinolone is likely sufficient. Although data are limited, this possibly holds even in the elderly patients with comorbidities or bacteremia.
authors: Department of Infectious Diseases, Leiden University Medical Center, Postbox 9600, 2300 RC, Leiden, the Netherlands, w.e.van_der_starre@lumc.nl.
authors: Willize E
authors: WE
authors: van der Starre
authors: Jaap T
authors: JT
authors: van Dissel
authors: Cees
authors: C
authors: van Nieuwkoop