title: The emerging role of HLA-C in HIV-1 infection.
abstract: Recently, genome-wide association studies have identified the major histocompatibility complex class I protein HLA-C as an important molecule that affects HIV disease progression. The association between HLA-C and HIV disease outcome was originally determined through a single nucleotide polymorphism (SNP) 35 kb upstream of the HLA-C locus. More recent work has focused on elucidating the functional significance of the -35 SNP, and several groups now have demonstrated HLA-C surface expression to be a key element in control of HIV viral load, with higher surface expression associating with slower disease progression. Most recently, control of HLA-C surface expression has been correlated with the presence of microRNA binding sites that affect HLA-C expression and control of HIV disease. This review highlights these results and explores the ways in which HLA-C surface expression could affect immune system function in the setting of HIV disease.
authors: Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA. klcollin@med.umich.edu
authors: Deanna A
authors: DA
authors: Kulpa
authors: Kathleen L
authors: KL
authors: Collins
mesh_terms: D000595:Amino Acid Sequence; D018450:Disease Progression; D015658:HIV Infections / Q000235:genetics / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D015236:HLA-C Antigens / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D035683:MicroRNAs / Q000276:immunology; D008969:Molecular Sequence Data; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D054311:nef Gene Products, Human Immunodeficiency Virus / Q000276:immunology
chemical_list: D015236:HLA-C Antigens; D035683:MicroRNAs; D054311:nef Gene Products, Human Immunodeficiency Virus