title: Human epicardial fat: what is new and what is missing?
abstract: 1. Putative physiological functions of human epicardial adipose tissue (EAT) include: (i) lipid storage for the energy needs of the myocardium; (ii) thermoregulation, whereby brown fat components of EAT generate heat by non-shivering thermogenesis in response to core cooling; (iii) neuroprotection of the cardiac autonomic ganglia and nerves; and (iv) regulation of vasomotion and luminal size of the coronary arteries. Under pathophysiological circumstances, EAT may play an adverse paracrine role in cardiac arrhythmias and in lipotoxic cardiomyopathy, but of major current interest is its hypothetical role as an immunological organ contributing to inflammation around coronary artery disease (CAD). 2. The amount of EAT measured either by echocardiographic thickness over the free wall of the right ventricle or as volume by computed tomography expands in patients with obesity both without and with CAD. The mechanisms other than obesity governing the increase in EAT volume in CAD are unknown, but EAT around CAD is infiltrated by chronic inflammatory cells and overexpresses genes for adipokines that have pro- or anti-inflammatory actions and regulate oxidative stress plus angiogenesis. 3. Many cross-sectional studies have shown positive associations between increased EAT mass and stable CAD burden. One prospective population-based epidemiological study suggested that EAT volume at baseline is a predictor of acute myocardial infarction, but was without significant incremental predictive value after adjustment for established cardiovascular risk factors. However, strategies are needed to obtain robust epidemiological, interventional and experimental evidence to prove or disprove the hypothesis that EAT is a cardiovascular risk factor locally contributing to CAD.
authors: Endocrinology and Diabetes Division 111D, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA. hsacks@hotmail.com
authors: Harold S
authors: HS
authors: Sacks
authors: John N
authors: JN
authors: Fain
mesh_terms: D054392:Adipokines / Q000378:metabolism; D000273:Adipose Tissue / Q000000981:diagnostic imaging / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D001833:Body Temperature Regulation / Q000502:physiology; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D003331:Coronary Vessels / Q000276:immunology / Q000378:metabolism / Q000502:physiology; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging / Q000294:innervation / Q000502:physiology; D006801:Humans; D008297:Male; D051379:Mice; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology; D010496:Pericardium / Q000000981:diagnostic imaging / Q000378:metabolism / Q000502:physiology*; D011859:Radiography; D051381:Rats; D015431:Weight Loss / Q000502:physiology
chemical_list: D054392:Adipokines