title: Progression of low-grade dysplasia in ulcerative colitis: effect of colonic location.
abstract: BACKGROUND
  Emerging evidence suggests that the biology of sporadic colorectal neoplasia may differ between the proximal and distal colon. Whether such a difference exists in colitis-associated colorectal neoplasia is unknown.
  
  
  OBJECTIVE
  To compare the rate of progression to advanced neoplasia (AN) between proximal and distal dysplasia in patients with ulcerative colitis (UC).
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Tertiary medical center.
  
  
  METHODS
  From an institutional database of more than 700 patients with UC who underwent 2 or more surveillance colonoscopies between 1994 and 2006, we identified patients with extensive UC and low-grade dysplasia (LGD). Neoplasia proximal to the splenic flexure was considered proximal.
  
  
  METHODS
  Progression to AN, defined as high-grade dysplasia (HGD) or colorectal cancer (CRC).
  
  
  RESULTS
  Among 121 patients with LGD, all 7 who progressed to CRC and 6 of 8 who progressed to HGD had distal LGD initially. Subjects with distal LGD had a significantly shorter time to progression than those with proximal LGD (P = .019); 5-year AN-free survivals for distal and proximal LGD were 75 ± 7% and 95 ± 3%, respectively (hazard ratio [HR] 5.0; 95% CI, 1.1-22.0). Additionally, flat LGD was significantly more likely to progress than raised LGD on univariate testing (HR 3.6; 95% CI, 1.3-10.1). Neither morphology nor sidedness remained significant in multivariable testing, although there was little change in the HRs (HR 2.4; 95% CI, 0.8-7.1 for morphology; HR 3.5; 95% CI, 0.7-16.8 for sidedness) in proportional hazards modeling.
  
  
  CONCLUSIONS
  Nonrandomized, retrospective trial and low incidence of AN.
  
  
  CONCLUSIONS
  In patients with long-standing, extensive UC, distal LGD is more common and progresses more rapidly to AN than proximal LGD.
authors: The Dr. Henry D. Janowitz Division of Gastroenterology, The Mount Sinai School of Medicine, New York, New York 10029, USA.
authors: Robert
authors: R
authors: Goldstone
authors: Steven
authors: S
authors: Itzkowitz
authors: Noam
authors: N
authors: Harpaz
authors: Thomas
authors: T
authors: Ullman
mesh_terms: D000328:Adult; D003093:Colitis, Ulcerative / Q000150:complications* / Q000473:pathology*; D003110:Colonic Neoplasms / Q000209:etiology* / Q000473:pathology*; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D013997:Time Factors