title: Clinical significance of elevated B-type natriuretic peptide in patients with acute lung injury with or without right ventricular dilatation: an observational cohort study.
abstract: BACKGROUND
  The primary objective of this study was to examine levels of B-type natriuretic peptide (BNP) in mechanically ventilated patients with acute lung injury and to test whether the level of BNP would be higher in patients with right ventricular dilatation and would predict mortality.
  
  
  METHODS
  This was a prospective, observational cohort study of 42 patients conducted in the intensive care unit of a tertiary care university hospital. BNP was measured and transthoracic echocardiography was performed within 48 hours of the onset of acute lung injury. The left ventricular systolic and diastolic function, right ventricular systolic function, and cardiac output were assessed. BNP was compared in patients with and without right ventricular dilatation, as well as in survivors versus nonsurvivors.
  
  
  RESULTS
  BNP was elevated in mechanically ventilated patients with acute lung injury (median 420 pg/ml; 25-75% interquartile range 156-728 pg/ml). There was no difference between patients with and without right ventricular dilatation (420 pg/ml, 119-858 pg/ml vs. 387 pg/ml, 156-725 pg/ml; p = 0.96). There was no difference in BNP levels between the patients who died and those who survived at 30 days (420 pg/ml, 120-728 pg/ml vs. 385 pg/ml, 159-1070 pg/ml; p = 0.71).
  
  
  CONCLUSIONS
  In patients with acute lung injury the level of BNP is increased, but there is no difference in the BNP level between patients with and without right ventricular dilatation. Furthermore, BNP level is not predictive of mortality in this population.
authors: Cardiovascular Research Institute, University of California, San Francisco, CA, 94143, USA. Kathleen.Liu@ucsf.edu.
authors: Magda
authors: M
authors: Cepkova
authors: Vineet
authors: V
authors: Kapur
authors: Xiushui
authors: X
authors: Ren
authors: Thomas
authors: T
authors: Quinn
authors: Hanjing
authors: H
authors: Zhuo
authors: Elyse
authors: E
authors: Foster
authors: Michael A
authors: MA
authors: Matthay
authors: Kathleen D
authors: KD
authors: Liu