title: Renal toxicity of lisinopril and rosuvastatin, alone and in combination, in Wistar rats.
abstract: The aim of study was to evaluate the effect of commonly used lisinopril, rosuvastatin and their combined action on site-specific nephrotoxicity in rats using clusterin and microalbumin nephrotoxic biomarkers and other related parameters using oral gavage. Rosuvastatin at 2 different doses showed increase in urinary microalbumin levels whereas lisinopril and its combination with rosuvastatin at 2 different doses did not show urinary microalbumin excretion indicating beneficial effects of lisinopril in terms of reducing microalbumin. Urinary clusterin levels significantly increased in high-dose treated animals of lisinopril and rosuvastatin. The use of lisinopril plus rosuvastatin at low dose also led to worsened renal function by raising urinary clusterin levels (217 ± 4.6 ng/ml) when compared with the control (143 ± 3.3 ng/ml). Renal histopathology showed multifocal regeneration of tubules indicating proximal tubule damaged. These results indicate that lisinopril (50 mg/kg), rosuvastatin (100 mg/kg), lisinopril+rosuvastatin (20+40 mg/kg) and lisinopril+rosuvastatin (50+100 mg/kg) showed toxicity only on proximal tubules.
authors: Department of Pharmacology, L. M. College of Pharmacy, Navarangpura, Ahmedabad, India.
authors: Hardik
authors: H
authors: Dodiya
authors: Mukul
authors: M
authors: Jain
authors: Sunita S
authors: SS
authors: Goswami
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000473:pathology; D000419:Albuminuria; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000633:toxicity*; D000818:Animals; D015415:Biomarkers; D051152:Clusterin / Q000187:drug effects / Q000652:urine; D004338:Drug Combinations; D005260:Female; D005464:Fluorobenzenes / Q000633:toxicity*; D007687:Kidney Tubules, Proximal / Q000187:drug effects / Q000473:pathology; D017706:Lisinopril / Q000633:toxicity*; D011743:Pyrimidines / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D000068718:Rosuvastatin Calcium; D013449:Sulfonamides / Q000633:toxicity*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D015415:Biomarkers; D051152:Clusterin; D004338:Drug Combinations; D005464:Fluorobenzenes; D011743:Pyrimidines; D013449:Sulfonamides; D000068718:Rosuvastatin Calcium; D017706:Lisinopril