title: Lipid nanoparticles as carrier for octyl-methoxycinnamate: in vitro percutaneous absorption and photostability studies.
abstract: The aim of the present study was the evaluation of lipid nanoparticles (solid lipid nanoparticles, SLN, and nanostructured lipid carriers, NLC) as potential carriers for octyl-methoxycinnamate (OMC). The release pattern of OMC from SLN and NLC was evaluated in vitro, determining its percutaneous absorption through excised human skin. Additional in vitro studies were performed in order to evaluate, after UVA radiation treatment, the spectral stability of OMC-loaded lipid nanoparticles. From the obtained results, ultrasonication method yielded both SLN and NLC in the nanometer range with a high active loading and a particle shape close to spherical. Differential scanning calorimetry data pointed out the key role of the inner oil phase of NLC in stabilizing the particle architecture and in increasing the solubility of OMC as compared with SLN. In vitro results showed that OMC, when incorporated in viscosized NLC dispersions (OMC-NLC), exhibited a lower flux with respect to viscosized SLN dispersions (OMC-SLN) and two reference formulations: a microemulsion (OMC-ME) and a hydroalcoholic gel (OMC-GEL). Photostability studies revealed that viscosized NLC dispersions were the most efficient at preserving OMC from ultraviolet-mediated photodegradation.
authors: Dipartimento di Scienze del Farmaco, Facoltà di Farmacia, Università di Catania, 95125 Catania, Italy. capuglia@unict.it
authors: Carmelo
authors: C
authors: Puglia
authors: Francesco
authors: F
authors: Bonina
authors: Luisa
authors: L
authors: Rizza
authors: Paolo
authors: P
authors: Blasi
authors: Aurelie
authors: A
authors: Schoubben
authors: Rosario
authors: R
authors: Perrotta
authors: Maria Stella
authors: MS
authors: Tarico
authors: Elisabetta
authors: E
authors: Damiani
mesh_terms: D000328:Adult; D002152:Calorimetry, Differential Scanning / Q000379:methods; D002626:Chemistry, Pharmaceutical / Q000379:methods; D002934:Cinnamates / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D004655:Emulsions / Q000737:chemistry; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D009821:Oils / Q000737:chemistry; D010316:Particle Size; D010539:Permeability; D055668:Photochemical Processes; D012867:Skin / Q000187:drug effects; D012869:Skin Absorption
chemical_list: D002934:Cinnamates; D004337:Drug Carriers; D004655:Emulsions; D008055:Lipids; D009821:Oils; C118580:octylmethoxycinnamate