title: Effects of gastrodia elata bl on phencyclidine-induced schizophrenia-like psychosis in mice.
abstract: It has been demonstrated that 5-HT(1A) receptors play an important role in the pathophysiology of schizophrenia. Because Gastrodia elata Bl (GE) modulates the serotonergic system, we examined whether GE could affect phencyclidine (PCP)-induced abnormal behavior in mice. Repeated treatment with PCP increased immobility time, while it decreased social interaction time and recognition memory. PCP-induced abnormal behaviors were significantly attenuated by GE, and these effects were comparable to those of 8-OH-DPAT, a 5-HT(1A) receptor agonist. Furthermore, GE-mediated effects were counteracted by WAY 100635, a 5-HT(1A) receptor antagonist. Our results suggest that the antipsychotic effects of GE are, at least in part, mediated via activation of 5-HT(1A) in mice.
authors: Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon 200-701, South Korea.
authors: E-J
authors: EJ
authors: Shin
authors: J-M
authors: JM
authors: Kim
authors: X-K T
authors: XK
authors: Nguyen
authors: T-T L
authors: TT
authors: Nguyen
authors: S Y
authors: SY
authors: Lee
authors: J-H
authors: JH
authors: Jung
authors: M J
authors: MJ
authors: Kim
authors: W K
authors: WK
authors: Whang
authors: K
authors: K
authors: Yamada
authors: T
authors: T
authors: Nabeshima
authors: H-C
authors: HC
authors: Kim