title: Rat hyperactivity by bisphenol A, but not by its derivatives, 3-hydroxybisphenol A or bisphenol A 3,4-quinone.
abstract: Detoxification in the central nervous system is largely unknown. The mechanism of neurotoxicity of bisphenol A, a toxic environmental chemical remains obscure. We examined the effects of bisphenol A, and its derivatives, 3-hydroxybisphenol A and bisphenol A 3,4-quinone on rat behavior as possible metabolites of bisphenol A. A single intracisternal administration of bisphenol A (20 μg equivalent to 87 nmol) into 5-day-old male Wistar rats caused significant hyperactivity at 4-5 weeks of age. It was about 1.3 fold more active in the nocturnal phase than control rats. However, neither 3-hydroxybisphenol A nor bisphenol A 3,4-quinone at the same amount (87 nmol) increased the spontaneous motor activity. Gas chromatographic-mass spectrometric (GC-MS) analyses of the treated brain revealed that 7% of the parent chemical resided in the brain at 8 weeks of age, but its derivatives were not found. This suggested a difference in metabolic turnover of these compounds or a difference in their stabilities. We conclude that bisphenol A per se caused hyperactivity in the rat, eliminating the possibility that possible metabolic forms of bisphenol A, 3-hydroxybisphenol A and bisphenol A 3,4-quinone have the ability to elicit rat hyperactivity, probably because of longer-lasting residence of the parent compound in the brain.
authors: Center for Environmental Risk Research, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba 305-8506, Japan. ishidou@nies.go.jp
authors: Masami
authors: M
authors: Ishido
authors: Yoshinori
authors: Y
authors: Masuo
authors: Masanori
authors: M
authors: Terasaki
authors: Masatoshi
authors: M
authors: Morita
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds; D016227:Benzoquinones / Q000633:toxicity*; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D010636:Phenols / Q000493:pharmacokinetics / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D016227:Benzoquinones; D010636:Phenols; C530259:3-hydroxybisphenol A; C487806:bisphenol A 3,4-quinone; D000098826:Bisphenol A Compounds; C006780:bisphenol A