title: [State of the endothelium and hemostasis in acute leukemia].
abstract: The review presents modern conceptions of disturbances in endothelial lining of the vessels and plasmic hemostasis in patients with acute leukemia; different mechanisms of coagulation disorders in acute leukemia: effects of leukemic cells containing procoagulants, fibrinolytic and antifibrinolytic substances, of intensive chemotherapy and inflammation. All these impacts impair endothelial cells and trigger plasmic coagulation cascade; the initiator of coagulation is a tissue factor. Mechanisms of this process and statistics of thrombohemorrhagic complications in different variants of acute leukemia are outlined.
authors: L N
authors: LN
authors: Tarasova
authors: O Iu
authors: OIu
authors: Skol'skaia
authors: S G
authors: SG
authors: Vladimirova
mesh_terms: D000208:Acute Disease; D004730:Endothelium, Vascular / Q000502:physiology*; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D007938:Leukemia / Q000097:blood* / Q000503:physiopathology*