title: Recurrent torsades de pointes after catheter ablation of incessant ventricular bigeminy in combination with QT prolongation.
abstract: A 45-year-old woman, who had received a single-chamber implantable cardioverter defibrillator (ICD) due to ventricular fibrillation 5 years ago, was admitted for catheter ablation of incessant right ventricular outflow tract bigeminy. After successful ablation recurrent torsades de pointes associated with a prolonged corrected QT (QTc) interval were initiated by polymorphic premature ventricular complexes. Genetic testing revealed a heterozygous missense mutation in the SCN5A-gene (p.Arg190Gln, Exon 5), consistent with long QT-syndrome 3. DDDR pacing following implantation of an atrial lead prevented further ventricular tachyarrhythmias.
authors: Medizinische Klinik I, Klinikum München Pasing, Akademisches Lehrkrankenhaus der Universität München, Steinerweg 5, 81241 München, Germany. Christopher.Reithmann@kliniken-pasing-perlach.de
authors: Christopher
authors: C
authors: Reithmann
authors: Michael
authors: M
authors: Fiek
authors: Britt-Maria
authors: BM
authors: Beckmann
authors: Stefan
authors: S
authors: Kääb
mesh_terms: D017115:Catheter Ablation / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000209:etiology* / Q000517:prevention & control*; D008875:Middle Aged; D010138:Pacemaker, Artificial; D016171:Torsades de Pointes / Q000209:etiology* / Q000517:prevention & control*; D016896:Treatment Outcome; D014694:Ventricular Outflow Obstruction / Q000150:complications / Q000601:surgery*