title: A single nucleotide polymorphism in the matrix metalloproteinase 2 promoter is closely associated with high risk of nasopharyngeal carcinoma in Cantonese from southern China.
abstract: Matrix metalloproteinase 2 (MMP2) has been shown to play an important role in several steps of cancer development. The -1306C/T polymorphism of the MMP2 gene displays a strikingly lower promoter activity than the T allele, and the CC genotype in the MMP2 promoter has been reported to associate with the development of several cancers. To assess the contribution of the MMP2 -1306C/T polymorphism to the risk of nasopharyngeal carcinoma (NPC), we conducted a case-control study and analyzed MMP2 genotypes in 370 patients with NPC and 390 frequency-matched controls using real-time PCR-based TaqMan allele analysis. We found that subjects with the CC genotype had an increased risk (OR = 1.55, 95% CI = 1.05-2.27) of developing NPC compared to those with the CT or TT genotypes. Furthermore, we found that the risk of NPC was markedly increased in subjects who were smokers (OR = 15.04, 95% CI = 6.65-33.99), heavy smokers who smoked ≥ 20 pack-years (OR = 18.66, 95% CI = 7.67-45.38), or young (<60 years) at diagnosis (OR = 1.52, 95% CI = 1.01-2.29). Our results provide molecular epidemiological evidence that the MMP2 -1306C/T promoter polymorphism is associated with NPC risk, and this association is especially noteworthy in heavy smokers.
authors: State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P. R. China. shaojy@sysucc.org.cn
authors: Jian-Yong
authors: JY
authors: Shao
authors: Yun
authors: Y
authors: Cao
authors: Xiao-Ping
authors: XP
authors: Miao
authors: Ma-Yan
authors: MY
authors: Huang
authors: Ling
authors: L
authors: Deng
authors: Jian-Jun
authors: JJ
authors: Hao
authors: Xiao-Man
authors: XM
authors: Liang
authors: Li-Fu
authors: LF
authors: Hu
authors: Ingemar
authors: I
authors: Ernberg
authors: Dong-Xin
authors: DX
authors: Lin
authors: Yi-Xin
authors: YX
authors: Zeng
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D002277:Carcinoma; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000235:genetics*; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D060888:Real-Time Polymerase Chain Reaction; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*
chemical_list: C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2