title: Memory rescue and enhanced neurogenesis following electrical stimulation of the anterior thalamus in rats treated with corticosterone.
abstract: Deep brain stimulation has been investigated as a treatment for memory disturbance but its mechanisms remain elusive. We show that anterior thalamic nucleus (ATN) stimulation administered to corticosterone-treated rats one month prior to testing improved performance on a delayed non-matching to sample task and increased hippocampal neurogenesis. In contrast, no behavioral changes were observed in animals that were tested a few days after surgery. Results of this study suggests that the behavioral effects of ATN stimulation in corticosterone-treated animals was likely dependent on long-term plastic changes, including the development of newly borne dentate gyrus cells of sufficient functional maturity.
authors: Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Canada. Clement.Hamani@uhn.on.ca
authors: Clement
authors: C
authors: Hamani
authors: Scellig S
authors: SS
authors: Stone
authors: Ariel
authors: A
authors: Garten
authors: Andres M
authors: AM
authors: Lozano
authors: Gordon
authors: G
authors: Winocur
mesh_terms: D000818:Animals; D020643:Anterior Thalamic Nuclei; D003345:Corticosterone / Q000494:pharmacology*; D046690:Deep Brain Stimulation; D004558:Electric Stimulation; D006624:Hippocampus / Q000166:cytology* / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects; D055495:Neurogenesis / Q000187:drug effects; D009483:Neuropsychological Tests; D051381:Rats; D020318:Rats, Long-Evans
chemical_list: D003345:Corticosterone