title: Synthesis and antibacterial activity of aromatic and heteroaromatic amino alcohols.
abstract: Two series of aromatic and heteroaromatic amino alcohols were synthesized from alcohols and aldehydes and evaluated for their antibacterial activities. All the octylated compounds displayed a better activity against the four bacteria tested when evaluated by the agar diffusion method and were selected for the evaluation of minimal inhibitory concentration. The best results were obtained for p-octyloxybenzyl derivatives against Staphylococcus epidermidis (minimal inhibitory concentrations = 32 μm).
authors: Departamento de Qumica, ICE, Universidade Federal de Juiz de Fora, 36036-330 Juiz de Fora, MG, Brazil.
authors: Camila G
authors: CG
authors: de Almeida
authors: Samira G
authors: SG
authors: Reis
authors: Angelina M
authors: AM
authors: de Almeida
authors: Claudio G
authors: CG
authors: Diniz
authors: Vânia L
authors: VL
authors: da Silva
authors: Mireille
authors: M
authors: Le Hyaric
mesh_terms: D000605:Amino Alcohols / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013212:Staphylococcus epidermidis / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000605:Amino Alcohols; D000900:Anti-Bacterial Agents