title: Study of the effect of iron overload on the function of endocrine glands in male thalassemia patients.
abstract: BACKGROUND
  Iron overload is an important issue in the state of thalassemic patients due to the harmful effect of high concentration of iron deposited in different tissues in human body including endocrine glands. In the present work, an attempt is carried out to estimate the effect of iron overload in thalassemic patients on the function of endocrine glands through the estimation of their ability to secrete adequate amounts of certain hormones.
  
  
  METHODS
  Seventy eight male children with beta-thalassemia, in the age-group of 4-11 years, were enrolled for this research. These children were being treated with frequent transfusions and long-term iron chelation therapy. Thirty age and sex matched children without thalassemia constituted the control group. Ferritin and different hormones were estimated by ELISA technique.
  
  
  RESULTS
  The results showed a mild reduction in the function of endocrine glands through the decrease in the level of some hormones. These changes due mainly to the hypoxia and precipitation of iron in certain glands and overlapping with the synthesis or secretion of the hormones.
  
  
  CONCLUSIONS
  There is a different hormonal disturbances in beta thalassemia patients. Reduction of total body iron store is an important goal of the treatment of thalassemia and measuring the hormones concentration is necessary for the follow up of the thalassemic patients especially during puberty.
authors: Departments of Internal Medicine, College of Medicine, Al-Kufa University, Iraq.
authors: Mohammed Saied
authors: MS
authors: Abdulzahra
authors: Hussein Kadhem
authors: HK
authors: Al-Hakeim
authors: Mahdi Muhammed
authors: MM
authors: Ridha