title: pH-responsive self-duplex of (Py)A-substituted oligodeoxyadenylate in graphene oxide solution as a molecular switch.
abstract: In this paper, we demonstrated a highly discriminated and reliable molecular switch based on the interaction between the self-duplex of (Py)A-substituted oligodeoxyadenylate and graphene oxide in aqueous solution. This system showed a clear on/off state through the association and dissociation of (Py)A-modified oligodeoxynucleotide with graphene oxide in manipulated pH conditions, high amplitude efficiency for at least 50 cycles, and rapid response within seconds. Our molecular switch system has high reproducibility and simple operation by using pH stimulus.
authors: Laboratory for Modified Nucleic Acid Systems, Department of Chemistry, Division of IBB, Pohang University of Science and Technology, Pohang, South Korea.
authors: Jeong Wu
authors: JW
authors: Yi
authors: Jaesung
authors: J
authors: Park
authors: Kwang S
authors: KS
authors: Kim
authors: Byeang Hyean
authors: BH
authors: Kim
mesh_terms: D003839:Deoxyadenosines / Q000737:chemistry*; D005453:Fluorescence; D006108:Graphite / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D010087:Oxides / Q000737:chemistry*; D011721:Pyrenes / Q000737:chemistry*; D012996:Solutions; D014867:Water / Q000737:chemistry
chemical_list: D003839:Deoxyadenosines; D010087:Oxides; D011721:Pyrenes; D012996:Solutions; D014867:Water; D006108:Graphite; C030984:pyrene