title: Systematic prediction of gene function in Arabidopsis thaliana using a probabilistic functional gene network.
abstract: AraNet is a functional gene network for the reference plant Arabidopsis and has been constructed in order to identify new genes associated with plant traits. It is highly predictive for diverse biological pathways and can be used to prioritize genes for functional screens. Moreover, AraNet provides a web-based tool with which plant biologists can efficiently discover novel functions of Arabidopsis genes (http://www.functionalnet.org/aranet/). This protocol explains how to conduct network-based prediction of gene functions using AraNet and how to interpret the prediction results. Functional discovery in plant biology is facilitated by combining candidate prioritization by AraNet with focused experimental tests.
authors: Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea.
authors: Sohyun
authors: S
authors: Hwang
authors: Seung Y
authors: SY
authors: Rhee
authors: Edward M
authors: EM
authors: Marcotte
authors: Insuk
authors: I
authors: Lee
mesh_terms: D017360:Arabidopsis / Q000235:genetics*; D029681:Arabidopsis Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D053263:Gene Regulatory Networks; D017343:Genes, Plant / Q000502:physiology*; D018745:Genome, Plant; D023281:Genomics / Q000379:methods; D020407:Internet; D012984:Software
chemical_list: D029681:Arabidopsis Proteins