title: Dual modal in vivo imaging using upconversion luminescence and enhanced computed tomography properties.
abstract: In vivo upconversion luminescence (UCL) imaging, exhibiting favorable characteristics such as high photostability, no blinking, sharp emission lines, and long lifetimes, is recognized as the excellent and significant photoluminescence imaging for the future. To develop the imaging system with high visual sensitivity and tissue penetration, the functional molecules with X-ray computed tomography (CT) contrast were grafted onto upconversion nanoparticles to obtain β-NaYF(4):18% Yb(3+),2%Er(3+)@SiO(2)-I/PEG (UCNPs@SiO(2)-I/PEG) nanoprobes. These nanoprobes are water-soluble, have low cytotoxicity, and possess excellent UCL and remarkable CT contrast. Of particular note is that, besides the element iodine, rare earth elements (Y, Yb, and Er) present in the nanoprobes also show CT contrast. Moreover, no background autofluorescence signal is found in in vivo UCL images. We believe that these nanoprobes with dual modal in vivo imaging of UCL and CT can serve as a promising platform for clinical diagnosis or biomedical studies.
authors: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, P. R. China.
authors: Guo
authors: G
authors: Zhang
authors: Yanlan
authors: Y
authors: Liu
authors: Qinghai
authors: Q
authors: Yuan
authors: Chenghua
authors: C
authors: Zong
authors: Jianhua
authors: J
authors: Liu
authors: Lehui
authors: L
authors: Lu
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D004871:Erbium / Q000737:chemistry; D005459:Fluorides / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure; D012822:Silicon Dioxide / Q000737:chemistry; D014057:Tomography, X-Ray Computed; D015018:Ytterbium / Q000737:chemistry; D015019:Yttrium / Q000737:chemistry
chemical_list: D003287:Contrast Media; C525362:sodium yttriumtetrafluoride; D015019:Yttrium; D012822:Silicon Dioxide; D004871:Erbium; D015018:Ytterbium; D005459:Fluorides