title: Successful amelioration of tinnitus in a stroke patient by low-dose gabapentin.
abstract: Bilaterally progressive tinnitus and hearing impairment occurred in a hypertensive patient shortly after an episode of right ganglionic hemorrhage. Audiometric tests showed a mixed sensorineural and conduction hearing loss. When low-dose gabapentin was administrated for the pre-existing postherpetic thoracic neuralgia, the tinnitus dramatically improved but recurred after discontinuation of the drug. Hearing function did not change. In view of a controversy of gabapentin and tinnitus in previous trials, the findings in this patient support that low-dose gabapentin benefits the subgroup of tinnitus patients with secondary contributing factors, such as stroke.
authors: Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, and College of Medicine, Chang Gung University, Kaohsiung, Taiwan.
authors: Wei-Hsi
authors: WH
authors: Chen
authors: Hsin-Ling
authors: HL
authors: Yin
mesh_terms: D000588:Amines / Q000008:administration & dosage*; D001301:Audiometry, Pure-Tone; D020145:Basal Ganglia Hemorrhage / Q000150:complications* / Q000175:diagnosis; D002533:Cerebral Angiography / Q000379:methods; D003509:Cyclohexanecarboxylic Acids / Q000008:administration & dosage*; D018691:Excitatory Amino Acid Antagonists / Q000008:administration & dosage*; D000077206:Gabapentin; D046089:Hearing Loss, Mixed Conductive-Sensorineural / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D051474:Neuralgia, Postherpetic / Q000150:complications / Q000188:drug therapy*; D020521:Stroke / Q000150:complications* / Q000175:diagnosis; D014012:Tinnitus / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage*
chemical_list: D000588:Amines; D003509:Cyclohexanecarboxylic Acids; D018691:Excitatory Amino Acid Antagonists; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin