title: Diffusion-weighted magnetic resonance imaging in patients selected for radical cystectomy: detection rate of pelvic lymph node metastases.
abstract: OBJECTIVE
  To evaluate whether DW-MRI improves the detection of pelvic lymph nodes metastates in patients with bladder cancer undergoing radical cystectomy.
  
  
  METHODS
  36 patients with CT scan negative for nodal metastates underwent DW-MRI before surgery. Diagnostic accuracy of DW-MRI was compared with histopathological findings.
  
  
  RESULTS
  Mean ADC value was 0.85 × 10(-3) mm(3)/s in the nodal metastatic group and 1 × 10(-3) mm(3)/s in the nodal non-metastatic group (P = 0.02). The ADC cut-off value, obtained by the ROC curve was 0.86 × 10(-3) mm(3)/s. Patient-based sensitivity, specificity and positive and negative predictive values were 76.4%, 89.4%, 26.6%, and 71.4%, respectively.
  
  
  CONCLUSIONS
  DW-MRI may be used to differentiate metastatic from non-metastatic lymph nodes in patients with high-grade bladder cancer.
authors: Radiology Department, University Campus Bio Medico, Rome, Italy. rocco.papalia@unicampus.it
authors: Rocco
authors: R
authors: Papalia
authors: Giuseppe
authors: G
authors: Simone
authors: Rosario
authors: R
authors: Grasso
authors: Raffaele
authors: R
authors: Augelli
authors: Eliodoro
authors: E
authors: Faiella
authors: Salvatore
authors: S
authors: Guaglianone
authors: Roberto
authors: R
authors: Cazzato
authors: Riccardo
authors: R
authors: Del Vescovo
authors: Mariaconsiglia
authors: M
authors: Ferriero
authors: Bruno
authors: B
authors: Zobel
authors: Michele
authors: M
authors: Gallucci
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015653:Cystectomy; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D010388:Pelvis; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*