title: Towards a scheme of toxic equivalency factors (TEFs) for the acute toxicity of PAHs in sediment.
abstract: Toxic equivalency factors/quotients (TEF/TEQs) express the toxicity of complex mixtures. For PAHs, TEF values are available for assessing their carcinogenic potential and are expressed as benzo[a]pyrene equivalents. This study develops a similar approach for their acute toxicity in sediments. Acute toxicity (10 day EC₅₀) values were generated using the marine amphipod Corophium volutator bioassay for twelve low molecular weight PAHs. The results ranged from 24 to > 1000 mg/Kg sediment dry weight for 4-methyldibenzothiophene and anthracene, respectively. Phenanthrene was used as the reference compound (TEF=1) and so the TEQ values derived are expressed as phenanthrene equivalents. In order to illustrate the applicability of this approach to the development of marine indicators we plotted TEQ values for acute toxicity to UK environmental monitoring data. Further work is required to validate the TEF values produced and to extend the TEQ approach to include a wider range of low molecular weight PAHs.
authors: The Centre for Environment, Fisheries and Aquaculture Science, Cefas Lowestoft Laboratory, Pakefield Road, Lowestoft, Suffolk NR330HT, UK. tom.fisher@cefas.co.uk
authors: Tom T
authors: TT
authors: Fisher
authors: Robin J
authors: RJ
authors: Law
authors: Heather S
authors: HS
authors: Rumney
authors: Mark F
authors: MF
authors: Kirby
authors: Carole
authors: C
authors: Kelly
mesh_terms: D033304:Amphipoda / Q000187:drug effects; D000818:Animals; D001564:Benzo(a)pyrene / Q000633:toxicity; D001681:Biological Assay; D002273:Carcinogens / Q000633:toxicity; D004784:Environmental Monitoring / Q000379:methods* / Q000592:standards; D019015:Geologic Sediments / Q000737:chemistry*; D010616:Phenanthrenes / Q000633:toxicity; D011084:Polycyclic Aromatic Hydrocarbons / Q000592:standards / Q000633:toxicity*; D018570:Risk Assessment; D018675:Toxicity Tests / Q000379:methods* / Q000592:standards; D014874:Water Pollutants, Chemical / Q000592:standards / Q000633:toxicity*
chemical_list: D002273:Carcinogens; D010616:Phenanthrenes; D011084:Polycyclic Aromatic Hydrocarbons; D014874:Water Pollutants, Chemical; D001564:Benzo(a)pyrene; C031181:phenanthrene