title: [Changes in the incidence of multiresistant pathogens and its consequences in the intensive care unit].
abstract: Incidence of nosocomial infections and antibiotics resistance in intensive care units is increasing worldwide. Blood-stream infections of Gram-negative non-fermentive bacteria are associated with higher mortality.
  
  
  OBJECTIVE
  The aim of this study was to compare the antibiotic sensitivity of nosocomial blood-stream infections between years 2008-2010.
  
  
  RESULTS
  There was no difference in the sensitivity of methycillin-resistant Staphylococcus aureus and extended-spectrum beta lactamase producing Klebsiella spp. and Escherichia coli infections between the two years examined. Antibiotic resistance of Acinetobacter baumannii and Pseudomonas infections showed a marked increase in 2010 when compared to that found in 2008: there was no multiresistant Acinetobacter infection in samples obtained in 2008, but all these infections were found to be sensitive only to colistin in samples investigated in 2010. Sensitivity of Pseudomonas infections to carbapenems and piperacillin/tazobactam decreased significantly during this time. In addition, the authors found that the mortality of multiresistant Gram-negative blood-stream infections was higher compared to that caused by non-multiresistant bacteria.
  
  
  CONCLUSIONS
  These results emphasize the importance of infection control, adequate dosing and timing of antibiotics, and an appropriate number of nurses in intensive care unit.
authors: Semmelweis Egyetem, Általános Orvostudományi Kar I. Sebészeti Klinika Budapest Üllői út 78. 1082. orsiszucs@freemail.hu
authors: Orsolya
authors: O
authors: Szucs
authors: Katalin
authors: K
authors: Kristóf
authors: Katalin
authors: K
authors: Darvas
authors: Akos
authors: A
authors: Csomós
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016470:Bacteremia / Q000188:drug therapy* / Q000382:microbiology* / Q000401:mortality; D002985:Clinical Protocols / Q000592:standards; D003428:Cross Infection / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology* / Q000401:mortality; D004352:Drug Resistance, Microbial; D024901:Drug Resistance, Multiple, Bacterial; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D015994:Incidence; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D008826:Microbial Sensitivity Tests; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents