title: The effects of anesthetic preconditioning with sevoflurane in an experimental lung autotransplant model in pigs.
abstract: BACKGROUND
  Ischemia-reperfusion lung injury is doubly important in thoracic surgery because of the associated ventilation damage to 1 lung. In this study we evaluated the cytoprotective effects of sevoflurane in a pulmonary autotransplant model in pigs.
  
  
  METHODS
  Twenty Large White pigs undergoing pneumonectomy plus lung autotransplant were divided into 2 10-member groups on the basis of the anesthetic received (propofol or sevoflurane). Proinflammatory mediators, oxidative stress, nitric oxide metabolism, and hemodynamic and blood variables were measured at 5 different time points.
  
  
  RESULTS
  There was an increase of oxidative stress markers and proinflammatory mediators in the propofol group, whereas the hemodynamic variables were similar in both groups.
  
  
  CONCLUSIONS
  We demonstrated that sevoflurane decreased the inflammatory response and oxidative stress in a live ischemia-reperfusion lung model.
authors: Department of Anesthesiology, Gregorio Maranon University General Hospital, c/querol 5,3°c, Madrid, 28033, Spain. Kassss1@yahoo.es
authors: Javier
authors: J
authors: Casanova
authors: Ignacio
authors: I
authors: Garutti
authors: Carlos
authors: C
authors: Simon
authors: Ana
authors: A
authors: Giraldez
authors: Beatriz
authors: B
authors: Martin
authors: Guillermo
authors: G
authors: Gonzalez
authors: Leire
authors: L
authors: Azcarate
authors: Cruz
authors: C
authors: Garcia
authors: Elena
authors: E
authors: Vara
mesh_terms: D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D000975:Antioxidants / Q000008:administration & dosage*; D015415:Biomarkers / Q000378:metabolism; D019610:Cytoprotection; D006439:Hemodynamics / Q000187:drug effects; D018836:Inflammation Mediators / Q000378:metabolism; D053583:Interleukin-1beta / Q000378:metabolism; D055370:Lung Injury / Q000209:etiology / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D016040:Lung Transplantation / Q000009:adverse effects*; D008738:Methyl Ethers / Q000008:administration & dosage*; D009569:Nitric Oxide / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D009195:Peroxidase / Q000378:metabolism; D011013:Pneumonectomy; D011654:Pulmonary Edema / Q000209:etiology / Q000517:prevention & control; D015427:Reperfusion Injury / Q000209:etiology / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D000077149:Sevoflurane; D013552:Swine; D013997:Time Factors; D014182:Transplantation, Autologous; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D018685:Anesthetics, Inhalation; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D015415:Biomarkers; D018836:Inflammation Mediators; D053583:Interleukin-1beta; D008738:Methyl Ethers; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide; D000077149:Sevoflurane; D009195:Peroxidase; D019001:Nitric Oxide Synthase