title: Prognostic value of serum CD44, intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 levels in patients with indolent non-Hodgkin lymphomas.
abstract: Elevated serum CD44, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) have been linked to poor prognosis in aggressive lymphomas, but their utility in low grade lymphomas remains undefined. We evaluated serum CD44, VCAM-1 and ICAM-1 levels in 100 patients with newly diagnosed indolent NHL. The median pre-treatment values of the markers were as follows: CD44 540 ng/mL (range 156-1201), ICAM-1 311 ng/mL (range 102-1222) and VCAM-1 1165 ng/mL (range 248-4779). On univariate analysis, elevated sCD44, sICAM-1 and sVCAM-1 were significantly associated with worse overall (OS) and progression-free survival (PFS). In a subset analysis of patients with stage IV disease, the effects of sCD44 and sICAM-1 on OS persisted (p<0.05), as did the effect of sCD44 on PFS (p<0.01). In a multivariate analysis that included conventional prognostic factors and the Follicular Lymphoma International Prognostic Index (FLIPI) model, sICAM-1 demonstrated prognostic value for OS and PFS. We conclude that serum CD44, ICAM-1 and VCAM-1 can potentially be prognostic in patients with indolent NHL. Though the FLIPI model remains the gold standard for prognosis, these quantitative serologic markers may be useful as adjunct tools in assessing disease risk.
authors: University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA.
authors: Nina
authors: N
authors: Shah
authors: Fernando
authors: F
authors: Cabanillas
authors: Bradley
authors: B
authors: McIntyre
authors: Lei
authors: L
authors: Feng
authors: Peter
authors: P
authors: McLaughlin
authors: Maria A
authors: MA
authors: Rodriguez
authors: Jorge
authors: J
authors: Romaguera
authors: Anas
authors: A
authors: Younes
authors: Fredrick B
authors: FB
authors: Hagemeister
authors: Larry
authors: L
authors: Kwak
authors: Luis
authors: L
authors: Fayad
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000097:blood*; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D053208:Kaplan-Meier Estimate; D008228:Lymphoma, Non-Hodgkin / Q000097:blood* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D018960:Hyaluronan Receptors; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1