title: Hsp90 and client protein maturation.
abstract: Heat-shock protein 90 (Hsp90) is a molecular chaperone that assists in the maturation of a limited set of substrate proteins that are collectively referred to as clients. The majority of identified Hsp90 clients are involved in signal transduction, including many steroid hormone receptors and kinases. A handful of Hsp90 clients can be classified as nonsignal transduction proteins, including telomerase, cystic fibrosis transmembrane conductance regulator, and antigenic peptides destined for major histocompatibility complex. Because Hsp90 clients are causative agents in cancer and cystic fibrosis, research on Hsp90 has intensified in recent years. We review the historical path of Hsp90 research within each class of client (kinase, hormone receptor, and nonsignal transduction clients) and highlight current areas of active investigation.
authors: Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, MA, USA.
authors: Natalie
authors: N
authors: Wayne
authors: Parul
authors: P
authors: Mishra
authors: Daniel N
authors: DN
authors: Bolon
mesh_terms: D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000378:metabolism; D018841:HSP90 Heat-Shock Proteins / Q000235:genetics* / Q000378:metabolism*; D006728:Hormones / Q000378:metabolism; D006801:Humans; D011485:Protein Binding; D011494:Protein Kinases / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D011987:Receptors, Steroid / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D019098:Telomerase / Q000378:metabolism
chemical_list: D018841:HSP90 Heat-Shock Proteins; D006728:Hormones; D011956:Receptors, Cell Surface; D011987:Receptors, Steroid; D029701:Saccharomyces cerevisiae Proteins; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D011494:Protein Kinases; D019098:Telomerase