title: Breaking the cell cycle of HSCs by p57 and friends.
abstract: The cell cycle regulators involved in maintaining the quiescence, and thereby the self-renewal capacity, of somatic stem cells have long been elusive. Two new Cell Stem Cell articles in this issue (Matsumoto et al., 2011; Zou et al., 2011) now show that the CDK inhibitor p57 is a crucial brake for cycling HSCs, and links self-renewal activity to cell cycle quiescence.
authors: Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
authors: Melania
authors: M
authors: Tesio
authors: Andreas
authors: A
authors: Trumpp
mesh_terms: D053687:Adult Stem Cells / Q000378:metabolism*; D000818:Animals; D002470:Cell Survival; D016922:Cellular Senescence; D019938:Cyclin D1 / Q000378:metabolism*; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000378:metabolism*; D050761:Cyclin-Dependent Kinase Inhibitor p57 / Q000378:metabolism*; D050883:HSC70 Heat-Shock Proteins / Q000378:metabolism*; D006412:Hematopoietic Stem Cells / Q000378:metabolism*
chemical_list: C493965:Cdkn1c protein, mouse; D050761:Cyclin-Dependent Kinase Inhibitor p57; D050883:HSC70 Heat-Shock Proteins; D019938:Cyclin D1; D050760:Cyclin-Dependent Kinase Inhibitor p27