title: Light-induced cytotoxicity of a photochromic spiropyran.
abstract: In this work we present a novel water soluble spiropyran photoswitch that can be photonically activated inside live cells from a form that has no significant effect on the cellular survival to a form that induces a dramatic toxic response.
authors: Department of Chemical and Biological Engineering, Physical Chemistry, Chalmers University of Technology, Göteborg, 412 96, Sweden.
authors: Jesper R
authors: JR
authors: Nilsson
authors: Shiming
authors: S
authors: Li
authors: Björn
authors: B
authors: Önfelt
authors: Joakim
authors: J
authors: Andréasson
mesh_terms: D001578:Benzopyrans / Q000378:metabolism / Q000494:pharmacology*; D001692:Biological Transport; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D003116:Color; D057809:HEK293 Cells; D006801:Humans; D007211:Indoles / Q000378:metabolism / Q000494:pharmacology*; D008027:Light; D009574:Nitro Compounds / Q000378:metabolism / Q000494:pharmacology*; D017319:Photosensitizing Agents / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D001578:Benzopyrans; D007211:Indoles; D009574:Nitro Compounds; D017319:Photosensitizing Agents; C088184:spiropyran