title: New epothilone congeners from Sorangium cellulosum strain So0157-2.
abstract: As a continuous work to find more epothilone congeners produced by the epothilones A and B producing Sorangium cellulosum strain So0157-2 in the large-scale fermentation (5000 L), we reinvestigated the chemical compositions of the fermentation broth. Consequently, two new epothilone variants (1-2) and one new natural epothilone derivative (3) were isolated from the fermentation broth. Their structures were established as 16-ethyl epothilone B (1), 6-desmethyl-16-hydroxymethyl epothilone C (2) and 20-ethyl epothilone A (3), respectively, by an extensive NMR analysis.
authors: Zhejiang Hisun Pharmaceutical Co., Ltd., Taizhou, Zhejiang, China.
authors: Ji-Dong
authors: JD
authors: Wang
authors: Nan
authors: N
authors: Jiang
authors: Hui
authors: H
authors: Zhang
authors: Lin-Ping
authors: LP
authors: Ying
authors: Chuan-Xi
authors: CX
authors: Wang
authors: Wen-Sheng
authors: WS
authors: Xiang
authors: Bo
authors: B
authors: Wu
authors: Hai-Bin
authors: HB
authors: Wang
authors: Hua
authors: H
authors: Bai
mesh_terms: D002851:Chromatography, High Pressure Liquid; D034261:Epothilones / Q000737:chemistry / Q000302:isolation & purification*; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009231:Myxococcales / Q000737:chemistry*
chemical_list: D034261:Epothilones