title: Low-grade chronic inflammation in the peripheral blood and ovaries of women with polycystic ovarian syndrome.
abstract: The purpose of this study was to investigate chronic inflammation in the peripheral blood and ovaries of patients with polycystic ovary syndrome (PCOS). 86 PCOS patients and 50 controls were randomly enrolled in the study. Serum follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), blood routine test, lipid metabolism index, inflammation cytokines were detected. Ovary samples from PCOS group and control group were collected for macrophage and lymphocyte immunohistochemistry staining. Patients with PCOS showed significantly higher serum CRP, lymphocytes, monocytes, eosinophilic granulocytes, as well as higher triglycerides (TG), TNF-α and IL-6. PCOS ovary had greater number of macrophages and lymphocytes immersed throughout. In conclusion, PCOS patients exhibited hypertriglyceridemia and chronic inflammation, with elevated peripheral lymphocytes, monocytes, and eosinophilic granulocytes. In addition, their ovaries showed persistent chronic inflammation with a larger number of inflammatory cells immersed.
authors: Centre of Reproductive Medicine, Zhuhai Women and Children's Hospital and Health Institute, Zhuhai 519000, People's Republic of China.
authors: Yong-lao
authors: YL
authors: Xiong
authors: Xiao-yan
authors: XY
authors: Liang
authors: Xing
authors: X
authors: Yang
authors: Yi
authors: Y
authors: Li
authors: Li-na
authors: LN
authors: Wei
mesh_terms: D000328:Adult; D017252:CD3 Complex / Q000378:metabolism; D005260:Female; D005498:Follicular Phase / Q000097:blood; D006098:Granulocytes / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D006801:Humans; D015228:Hypertriglyceridemia / Q000209:etiology; D007150:Immunohistochemistry; D018836:Inflammation Mediators / Q000097:blood*; D007958:Leukocyte Count; D018950:Lipopolysaccharide Receptors / Q000378:metabolism; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D008264:Macrophages / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D009000:Monocytes / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D010053:Ovary / Q000276:immunology* / Q000473:pathology; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D055815:Young Adult
chemical_list: D017252:CD3 Complex; D018836:Inflammation Mediators; D018950:Lipopolysaccharide Receptors