title: IL-9 contributes to immunosuppression mediated by regulatory T cells and mast cells in B-cell non-hodgkin's lymphoma.
abstract: It has been known that regulatory T (Treg) cells and mast cells (MCs) are involved in tumor immunity regulation, but the exact roles and mechanisms of Treg cells and MCs in B-cell non-Hodgkin's lymphoma (NHL) are incompletely defined. In the present study, we found that the number of Foxp3(+) Treg cells and CD117(+) MCs increased in B-cell NHL patients. Concomitantly, a high level of interleukin (IL)-9 was observed in the sera from B-cell NHL patients. Neutralizing IL-9 significantly inhibited tumor growth in the lymphoma model of murine, and this process was associated with down-regulation of Treg cells and MCs. Furthermore, IL-9 was also demonstrated to induce expression of MC-related genes and proliferation of MCs from the bone marrow stem cells. Collectively, our results indicate that Treg cell and MCs are involved in immunosuppression in B-cell NHL, and IL-9 is a key mediator of Treg cells and MCs in that process. These findings provide novel insight for the pathogenesis and possible therapeutic strategy of B-cell NHL.
authors: Department of Hematology, Provincial Hospital Affiliated to Shandong University, No. 324 Jingwu Weiqi Road, Jinan, Shandong, 250021, People's Republic of China.
authors: Li-Li
authors: LL
authors: Feng
authors: Jun-Ming
authors: JM
authors: Gao
authors: Pei-Pei
authors: PP
authors: Li
authors: Xin
authors: X
authors: Wang
mesh_terms: D000818:Animals; D019138:Antibodies, Blocking / Q000008:administration & dosage; D001402:B-Lymphocytes / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D002478:Cells, Cultured; D051858:Forkhead Transcription Factors / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D007165:Immunosuppression Therapy; D016906:Interleukin-9 / Q000096:biosynthesis* / Q000097:blood / Q000235:genetics / Q000276:immunology; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D047368:Tumor Burden / Q000187:drug effects
chemical_list: D019138:Antibodies, Blocking; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D016906:Interleukin-9; D019009:Proto-Oncogene Proteins c-kit