title: Focal navigated laser photocoagulation in retinovascular disease: clinical results in initial case series.
abstract: OBJECTIVE
  To evaluate clinical results after the use of a novel integrated imaging and laser device to perform focal retinal navigated laser photocoagulation in perifoveal abnormalities and retinovascular disease.
  
  
  METHODS
  Interventional case series of 25 consecutive eyes with perifoveal and retinovascular diseases treated with a navigated laser photocoagulator Navilas (OD-OS, Berlin, Germany). We treated eyes with perifoveal telangiectasia (n = 3), central serous chorioretinopathy (n = 2), and diabetic macular edema with focal leakage (n = 20).
  
  
  RESULTS
  The treatments were performed without a contact lens and without topical anesthesia. There was no inadvertent photocoagulation of the fovea, and all laser applications accurately hit the preplanned points. Mean and median (± standard deviation) foveal thickness at baseline was 535 ± 171 μm and 402 ± 152 μm, respectively. Mean and median (± standard deviation) foveal thickness at 6 months was 318 ± 112 μm and 221 ± 127 μm, respectively. This represents a statistically significant decrease in foveal thickness (P = 0.003). Mean and median visual acuity at baseline was 20/80 and 20/50, respectively. Mean and median visual acuity at 6 months was 20/50 and 20/40, respectively, which represents a significant improvement (P = 0.011).
  
  
  CONCLUSIONS
  Precise retinal targeting with a navigated laser photocoagulator resulted in highly accurate perifoveal laser application and no foveal damage. At 6 months after the treatment, significant decreases in central foveal thickness and significant improvements in visual acuity were identified.
authors: Department of Ophthalmology, Jacobs Retina Center, Shiley Eye Center, University of California San Diego, La Jolla, California 92037, USA.
authors: Igor
authors: I
authors: Kozak
authors: Jae Suk
authors: JS
authors: Kim
authors: Stephen F
authors: SF
authors: Oster
authors: Jay
authors: J
authors: Chhablani
authors: William R
authors: WR
authors: Freeman
mesh_terms: D000328:Adult; D002199:Capillary Permeability; D056833:Central Serous Chorioretinopathy / Q000601:surgery*; D003930:Diabetic Retinopathy / Q000601:surgery*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D017075:Laser Coagulation; D008269:Macular Edema / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D058456:Retinal Telangiectasis / Q000601:surgery*; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology