title: Nuclear barrier hypothesis of aging as mechanism for trade-off growth to survival.
abstract: When the aging-dependent cellular behaviors toward growth factors and toxic stress have been analyzed, the perinuclear accumulation of the activated signals, either mitogenic or apoptotic, has been observed, suggesting the aging-dependent inefficiency of the nucleocytoplasmic trafficking of the signals. Thereby, it would be natural to assume the operation of the functional nuclear barrier in aging-dependent manner, which would be designated as "Park and Lim's Barrier." And for the ultimate transcriptional factor for these aging-dependent changes of the functional nuclear barrier, Sp1 transcriptional factor has been suggested to be the most probable candidate. This novel mechanism of aging-dependent operation of the functional nuclear barrier is proposed as the ultimate checking mechanism for cellular protection against toxic environment and the general mechanism for the trade-off growth to survival in aging.
authors: Department of Biochemistry and Molecular Biology, Seoul National University Medical School, Seoul, South Korea. scpark@snu.ac.kr
authors: Sang Chul
authors: SC
authors: Park
mesh_terms: D021581:Active Transport, Cell Nucleus; D000818:Animals; D017209:Apoptosis; D002467:Cell Nucleus / Q000378:metabolism*; D049109:Cell Proliferation; D002470:Cell Survival; D016922:Cellular Senescence; D006801:Humans; D016329:Sp1 Transcription Factor / Q000502:physiology
chemical_list: D016329:Sp1 Transcription Factor