title: Haemophilus influenzae infections in the H. influenzae type b conjugate vaccine era.
abstract: The widespread use of Haemophilus influenzae type b (Hib) conjugate vaccines has nearly eradicated invasive Hib disease where the vaccines are used. This success was accompanied by a shift in capsular serotypes of invasive H. influenzae disease, with nontypeable strains replacing type b strains as the most common bloodstream isolate, but there is no convincing evidence of a true increase in the incidence of non-serotype b invasive infections. H. influenzae causes predominantly mucosal infections. The introduction of vaccines for otitis media and global shifts in antimicrobial susceptibility emphasize the importance of continued surveillance of H. influenzae colonization and disease patterns.
authors: Division of Infectious Diseases, Department of Medicine, University at Buffalo, State University of New York, Buffalo, NY 14203, USA.
authors: Aarti
authors: A
authors: Agrawal
authors: Timothy F
authors: TF
authors: Murphy
mesh_terms: D006192:Haemophilus Infections / Q000453:epidemiology* / Q000382:microbiology* / Q000517:prevention & control; D018073:Haemophilus Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006193:Haemophilus influenzae / Q000145:classification* / Q000302:isolation & purification*; D006801:Humans; D015994:Incidence; D010033:Otitis Media / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control; D012703:Serotyping; D018074:Vaccines, Conjugate / Q000008:administration & dosage / Q000276:immunology
chemical_list: D018073:Haemophilus Vaccines; D018074:Vaccines, Conjugate