title: PET imaging predicts future body weight and cocaine preference.
abstract: Deficits in dopamine D2/D3 receptor (D2R/D3R) binding availability using PET imaging have been reported in obese humans and rodents. Similar deficits have been reported in cocaine-addicts and cocaine-exposed primates. We found that D2R/D3R binding availability negatively correlated with measures of body weight at the time of scan (ventral striatum), at 1 (ventral striatum) and 2 months (dorsal and ventral striatum) post scan in rats. Cocaine preference was negatively correlated with D2R/D3R binding availability 2 months (ventral striatum) post scan. Our findings suggest that inherent deficits in striatal D2R/D3R signaling are related to obesity and drug addiction susceptibility and that ventral and dorsal striatum serve dissociable roles in maintaining weight gain and cocaine preference. Measuring D2R/D3R binding availability provides a way for assessing susceptibility to weight gain and cocaine abuse in rodents and given the translational nature of PET imaging, potentially primates and humans.
authors: Behavioral Neuropharmacology Lab, Medical Department, Building 490, Brookhaven National Laboratory, Upton, NY 11973, USA.
authors: Michael
authors: M
authors: Michaelides
authors: Panayotis K
authors: PK
authors: Thanos
authors: Ronald
authors: R
authors: Kim
authors: Jacob
authors: J
authors: Cho
authors: Mala
authors: M
authors: Ananth
authors: Gene-Jack
authors: GJ
authors: Wang
authors: Nora D
authors: ND
authors: Volkow
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000502:physiology*; D003042:Cocaine / Q000008:administration & dosage*; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism*; D005518:Food Preferences / Q000502:physiology*; D008297:Male; D049268:Positron-Emission Tomography / Q000379:methods*; D020891:Raclopride / Q000493:pharmacokinetics*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D011954:Receptors, Dopamine / Q000378:metabolism*
chemical_list: D019275:Radiopharmaceuticals; D011954:Receptors, Dopamine; D020891:Raclopride; D003042:Cocaine