title: Seroepidemiologic study of pandemic (H1N1) 2009 during outbreak in boarding school, England.
abstract: We conducted a seroepidemiologic study during an outbreak of pandemic (H1N1) 2009 in a boarding school in England. Overall, 353 (17%) of students and staff completed a questionnaire and provided a serum sample. The attack rate was 40.5% and 34.1% for self-reported acute respiratory infection (ARI). Staff were less likely to be seropositive than students 13-15 years of age (staff 20-49 years, adjusted odds ratio [AOR] 0.30; >50 years AOR 0.20). Teachers were more likely to be seropositive than other staff (AOR 7.47, 95% confidence interval [CI] 2.31-24.2). Of seropositive persons, 44.6% (95% CI 36.2%-53.3%) did not report ARI. Conversely, of 141 with ARI and 63 with influenza-like illness, 45.8% (95% CI 37.0%-54.0%) and 30.2% (95% CI 19.2%-43.0%) had negative test results, respectively. A weak association was found between seropositivity and a prophylactic dose of antiviral agents (AOR 0.55, 95% CI 0.30-0.99); prophylactic antiviral agents lowered the odds of ARI by 50%.
authors: Health Protection Agency, London, UK.
authors: Sandra
authors: S
authors: Johnson
authors: Chikwe
authors: C
authors: Ihekweazu
authors: Pia
authors: P
authors: Hardelid
authors: Nika
authors: N
authors: Raphaely
authors: Katja
authors: K
authors: Hoschler
authors: Alison
authors: A
authors: Bermingham
authors: Muhammad
authors: M
authors: Abid
authors: Richard
authors: R
authors: Pebody
authors: Graham
authors: G
authors: Bickler
authors: John
authors: J
authors: Watson
authors: Eamonn
authors: E
authors: O'Moore
mesh_terms: D000293:Adolescent; D000328:Adult; D004196:Disease Outbreaks; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000453:epidemiology* / Q000821:virology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D058873:Pandemics; D015995:Prevalence; D012574:Schools; D057566:Self Report; D016036:Seroepidemiologic Studies; D055815:Young Adult