title: Flouxetine treatment acts selectively increasing myocardial beta1-adrenoceptor mRNA expression in stress-induced depression.
abstract: Changes in gene expression of beta1- and beta2-adrenoceptors (beta1 - and beta2-AR) in right and left atria and ventricles after fluoxetine treatment in stress-induced depression of adult rat males were studied. Elevated beta1-AR mRNA levels in the left atria and significantly higher levels of beta2-AR mRNA in the left atria and ventricles were observed in stress-induced depression in comparison with those of unstressed controls. Fluoxetine treatment led to increasing expression of beta1-AR mRNA in the right atria and left ventricles, while the level of beta2-AR mRNA remained unchanged. These findings suggest that fluoxetine therapy plays an important role in cardiac beta-adrenergic subsensitivity and gene regulation of beta-AR in animals with heightened sympathetic nervous activity.
authors: Institute of Nuclear Sciences "Vinca", Laboratory of Molecular Biology and Endocrinology, Belgrade, Serbia.
authors: N
authors: N
authors: Spasojevic
authors: L
authors: L
authors: Gavrilovic
authors: P
authors: P
authors: Jovanovic
authors: S
authors: S
authors: Dronjak
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D018076:DNA, Complementary / Q000096:biosynthesis / Q000235:genetics; D003863:Depression / Q000209:etiology* / Q000378:metabolism*; D005473:Fluoxetine / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D018342:Receptors, Adrenergic, beta-1 / Q000096:biosynthesis*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D013315:Stress, Psychological / Q000150:complications* / Q000378:metabolism / Q000523:psychology
chemical_list: D018076:DNA, Complementary; D005473:Fluoxetine; D012333:RNA, Messenger; D018342:Receptors, Adrenergic, beta-1; D017367:Selective Serotonin Reuptake Inhibitors