title: Comparison of edge vascular response after sirolimus- and paclitaxel-eluting stent implantation.
abstract: BACKGROUND
  To compare the edges vascular response, we analyzed the intravascular ultrasound (IVUS) parameters after implantation of the sirolimus-eluting stent (SES) or the paclitaxel-eluting stent (PES).
  
  
  METHODS
  Two hundred-two angina patients (123 men; 61.5 ± 9.2 years of age, SES: n = 91, PES: n=111) were enrolled. Both edge segments of the stent were analyzed. The change (Δ) of each parameter at follow-up was calculated.
  
  
  RESULTS
  The edge restenosis rate was higher in the PES group. However, the Δ Vessel, Δ Plaque and Δ Lumen volume at 5mm edge segments were not different between the two groups except the Δ Plaque volume at the distal segment, higher in the PES than the SES group (6.6 ± 15.7 vs. 1.0 ± 13.1mm(3), P=.016). In the PES group, lumen area at the both 1mm edge segments decreased because of plaque progression (proximal, 1.9 ± 1.5 to 2.2 ± 2.0mm(2), P=.095; distal, 0.6 ± 1.1 to 1.0 ± 1.4mm(2), P=.018) with negative remodeling (proximal, 9.9 ± 2.4 to 9.4 ± 2.6mm(2), P=.004; distal, 7.6 ± 2.4 to 7.2 ± 2.4mm(2), P=.052). Conversely, lumen area at these segments increased due to plaque regression (proximal, 3.2 ± 1.8 to 2.1 ± 1.6mm(2), P=.000; distal, 1.5 ± 1.4 to 0.9 ± 1.3mm(2), P=.000) even though there was negative remodeling in the SES group (proximal, 10.1 ± 2.4 to 9.6 ± 2.3mm(2), P=.019; distal, 7.8 ± 2.3 to 7.5 ± 2.3mm(2), P=.074). The Δ Plaque and Δ Lumen area at the both 1mm edge segments were more prominent in the PES group.
  
  
  CONCLUSIONS
  Compared to SES, PES was associated with luminal reduction accompanied by plaque progression with negative remodeling at edge segments.
authors: Department of Cardiology, Gil University, Gachon University of Medicine and Science, Incheon, Republic of Korea. kangwch@gilhospital.com
authors: Woong Chol
authors: WC
authors: Kang
authors: Yae Min
authors: YM
authors: Park
authors: Kwen Chul
authors: KC
authors: Shin
authors: Chan Il
authors: CI
authors: Moon
authors: Kyounghoon
authors: K
authors: Lee
authors: Seung Hwan
authors: SH
authors: Han
authors: Mi Seung
authors: MS
authors: Shin
authors: Jeonggeun
authors: J
authors: Moon
authors: Taehoon
authors: T
authors: Ahn
authors: Eak Kyun
authors: EK
authors: Shin
mesh_terms: D000368:Aged; D023903:Coronary Restenosis / Q000000981:diagnostic imaging* / Q000517:prevention & control; D054855:Drug-Eluting Stents / Q000639:trends; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage* / Q000009:adverse effects; D062645:Percutaneous Coronary Intervention / Q000639:trends; D011446:Prospective Studies; D020123:Sirolimus / Q000008:administration & dosage* / Q000009:adverse effects; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional / Q000379:methods
chemical_list: D017239:Paclitaxel; D020123:Sirolimus