title: Myelin regeneration in multiple sclerosis: targeting endogenous stem cells.
abstract: Regeneration of myelin sheaths (remyelination) after central nervous system demyelination is important to restore saltatory conduction and to prevent axonal loss. In multiple sclerosis, the insufficiency of remyelination leads to the irreversible degeneration of axons and correlated clinical decline. Therefore, a regenerative strategy to encourage remyelination may protect axons and improve symptoms in multiple sclerosis. We highlight recent studies on factors that influence endogenous remyelination and potential promising pharmacological targets that may be considered for enhancing central nervous system remyelination.
authors: MRC Cambridge Centre for Stem Cell Biology and Regenerative Medicine, and Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, United Kingdom.
authors: Jeffrey K
authors: JK
authors: Huang
authors: Stephen P J
authors: SP
authors: Fancy
authors: Chao
authors: C
authors: Zhao
authors: David H
authors: DH
authors: Rowitch
authors: Charles
authors: C
authors: Ffrench-Constant
authors: Robin J M
authors: RJ
authors: Franklin
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000166:cytology / Q000378:metabolism; D006801:Humans; D009103:Multiple Sclerosis / Q000503:physiopathology* / Q000628:therapy*; D009186:Myelin Sheath / Q000378:metabolism*; D009416:Nerve Regeneration / Q000187:drug effects / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology*