title: Seven-pass transmembrane cadherins: roles and emerging mechanisms in axonal and dendritic patterning.
abstract: The Flamingo/Celsr seven-transmembrane cadherins represent a conserved subgroup of the cadherin superfamily involved in multiple aspects of development. In the developing nervous system, Fmi/Celsr control axonal blueprint and dendritic morphogenesis from invertebrates to mammals. As expected from their molecular structure, seven-transmembrane cadherins can induce cell-cell homophilic interactions but also intracellular signaling. Fmi/Celsr is known to regulate planar cell polarity (PCP) through interactions with PCP proteins. In the nervous system, Fmi/Celsr can function in collaboration with or independently of other PCP genes. Here, we focus on recent studies which show that seven-transmembrane cadherins use distinct molecular mechanisms to achieve diverse functions in the development of the nervous system.
authors: Research Group Axon Guidance and Neuronal Connectivity, Max Planck Institute of Neurobiology, Am Kolpferspitz 18, 82152 Martinsried, Germany.
authors: Sandra
authors: S
authors: Berger-Müller
authors: Takashi
authors: T
authors: Suzuki
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology* / Q000648:ultrastructure; D015820:Cadherins / Q000737:chemistry* / Q000378:metabolism*; D016764:Cell Polarity; D003712:Dendrites / Q000502:physiology* / Q000648:ultrastructure; D018507:Gene Expression Regulation, Developmental; D009024:Morphogenesis; D009420:Nervous System / Q000033:anatomy & histology / Q000378:metabolism; D011487:Protein Conformation; D015398:Signal Transduction
chemical_list: D015820:Cadherins