title: Proton pump inhibitors--uncommon adverse effects.
abstract: BACKGROUND
  Proton pump inhibitors (PPIs) are one of the most popularly prescribed drugs in Australia for conditions such as gastro-oesophageal reflux disease, peptic ulcer disease and functional dyspepsia. Despite their good safety profile, PPIs have potential adverse effects, yet they are often overprescribed and without a clear indication.
  
  
  OBJECTIVE
  This article reviews the uncommon adverse effects of PPIs and provides recommendations for managing patients receiving this therapy.
  
  
  CONCLUSIONS
  Uncommon adverse effects include rebound acid hypersecretion syndrome, fragility fractures, interstitial nephritis, electrolyte derangements, pneumonia, enteric infection and vitamin B12 deficiency. General practitioners should be aware of these potential adverse effects and ensure that PPIs are used appropriately and where benefit clearly outweighs any harmful effects.
authors: Royal North Shore Hospital, Sydney, New South Wales. oys120_@hotmail.com
authors: Stephen
authors: S
authors: Oh
mesh_terms: D001315:Australia; D005767:Gastrointestinal Diseases / Q000188:drug therapy; D006801:Humans; D054328:Proton Pump Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D054328:Proton Pump Inhibitors