title: Clinical applications of dynamic susceptibility contrast perfusion-weighted MR imaging in brain tumours.
abstract: Magnetic resonance imaging (MRI) with a dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI) sequence to study brain tumours provides information on the haemodynamic characteristics of the neoplastic tissue. Brain perfusion maps and calculation of perfusion parameters, such as relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV) and mean transit time (MTT) allow assessment of vascularity and angiogenesis within tumours of the central nervous system (CNS), thus providing additional information to conventional MRI sequences. Although DSC-PWI has long been used, its clinical use in the study of brain tumours in daily clinical practice is still to be defined. The aim of this review was to analyse the application of perfusion MRI in the study of brain tumours by summarising our personal experience and the main results reported in the literature.
authors: NESMOS Department, Neuroradiology Faculty, Sant' Andrea Hospital, La Sapienza University, Via di Grottarossa 1035, 00189, Rome, Italy.
authors: A
authors: A
authors: Romano
authors: M C
authors: MC
authors: Rossi Espagnet
authors: L F
authors: LF
authors: Calabria
authors: V
authors: V
authors: Coppola
authors: L
authors: L
authors: Figà Talamanca
authors: V
authors: V
authors: Cipriani
authors: G
authors: G
authors: Minniti
authors: A
authors: A
authors: Pierallini
authors: L M
authors: LM
authors: Fantozzi
authors: A
authors: A
authors: Bozzao
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology* / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D003287:Contrast Media; D006439:Hemodynamics; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D010477:Perfusion
chemical_list: D003287:Contrast Media