title: A clinical analysis of primary testicular diffuse large B-cell lymphoma in China.
abstract: The objective of this study was to analyze the clinical behavior and treatment policy of patients with primary testicular diffuse large B-cell lymphoma by retrospective analysis of 32 patients at our institute. All patients underwent orchidectomy. Anthracycline-based chemotherapy was administered to 27 patients (84·38%), six of whom also received rituximab; prophylactic intrathecal chemotherapy was given to seven patients (21·88%); and eight patients (25%) received prophylactic scrotal radiotherapy. Thirteen patients had relapse, among whom 12 cases were extranodal recurrences. Seven patients had central nervous system involvement, and four patients relapsed in the contralateral testis. The presence of B symptoms, poor Eastern Cooperative Oncology Group performance status, left testicular involvement, central nervous system involvement, and first relapse within 1 year were associated with worse progression-free survival using univariate analysis. Poor Eastern Cooperative Oncology Group performance status, left testicular involvement, and surgery alone were negative prognostic factors for overall survival.
authors: Department of Medical Oncology,Fudan University Shanghai Cancer Center, 270 Dongan Road, Shanghai, China.
authors: Bing
authors: B
authors: Cao
authors: Dong-Mei
authors: DM
authors: Ji
authors: Xiao-Yan
authors: XY
authors: Zhou
authors: Ti-Ping
authors: TP
authors: Zhao
authors: Ye
authors: Y
authors: Guo
authors: Zhong-Hua
authors: ZH
authors: Wang
authors: Jun-Ning
authors: JN
authors: Cao
authors: Xi-Chun
authors: XC
authors: Hu
authors: Xiao-Nan
authors: XN
authors: Hong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002681:China; D003131:Combined Modality Therapy; D006801:Humans; D053208:Kaplan-Meier Estimate; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009919:Orchiectomy; D011379:Prognosis; D011878:Radiotherapy; D012008:Recurrence; D000069283:Rituximab; D013736:Testicular Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D055815:Young Adult
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; D000069283:Rituximab