title: Point of care technology or standard laboratory service in an emergency department: is there a difference in time to action? A randomised trial.
abstract: BACKGROUND
  Emergency Departments (ED) have a high flow of patients and time is often crucial. New technologies for laboratory analysis have been developed, including Point of Care Technologies (POCT), which can reduce the transport time and time of analysis significantly compared with central laboratory services. However, the question is if the time to clinical action is also reduced if a decisive laboratory answer is available during the first contact between the patient and doctor. The present study addresses this question: Does a laboratory answer, provided by POCT to the doctor who first attends the patient on admission, change the time to clinical decision in commonly occurring diseases in an ED compared with the traditional service from a central laboratory?
  
  
  METHODS
  We performed a randomised clinical trial with parallel design and allocation ratio 1:1. The eligibility Criteria were: All patients referred from General Practitioner or another referring doctor suspected for a deep venous thrombosis (DVT), acute coronary syndrome (ACS), acute appendicitis (AA) or acute infection (ABI). The outcome measure was the time spend from the blood sample was taken to a clinical decision was made.
  
  
  RESULTS
  The study period took place in October--November 2009 and from February to April 2010. 239 patients were eligible for the study. There was no difference between the groups suspected for DVT, ACS and AA, but a significant reduction in time for the ABI group (p:0.009), where the median time to decision was reduced from 7 hours and 33 minutes to 4 hours and 38 minutes when POCT was used. Only in the confirmation of ABI the time to action was significantly shorter.
  
  
  CONCLUSIONS
  Fast laboratory answers by POCT in an ED reduce the time to clinical decision significantly for bacterial infections. We suggest further studies which include a sufficient number of patients on deep venous thrombosis, acute appendicitis and acute coronary syndrome.
authors: Akutafdelingen, Kolding Sygehus, Kolding, Danmark. christian.backer.mogensen@slb.regionsyddanmark.dk
authors: Christian B
authors: CB
authors: Mogensen
authors: Anders
authors: A
authors: Borch
authors: Ivan
authors: I
authors: Brandslund
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis*; D001064:Appendicitis / Q000175:diagnosis*; D015415:Biomarkers / Q000032:analysis; D003718:Denmark; D004636:Emergency Service, Hospital / Q000458:organization & administration*; D006801:Humans; D007239:Infections / Q000175:diagnosis*; D007755:Laboratories, Hospital / Q000458:organization & administration*; D019095:Point-of-Care Systems / Q000458:organization & administration*; D012017:Referral and Consultation; D018709:Statistics, Nonparametric; D013997:Time Factors; D020246:Venous Thrombosis / Q000175:diagnosis*
chemical_list: D015415:Biomarkers