title: Serum pigment epithelium-derived factor levels are increased in patients with biopsy-proven nonalcoholic fatty liver disease and independently associated with liver steatosis.
abstract: BACKGROUND
  Increased serum concentrations of pigment epithelium-derived factor (PEDF) have been linked to the metabolic syndrome in the general population. However, the relationship between serum PEDF and nonalcoholic fatty liver disease (NAFLD), a hepatic manifestation of the metabolic syndrome, remains unknown.
  
  
  METHODS
  We assayed serum PEDF levels in 156 patients with biopsy-proven NAFLD and 103 nonsteatotic control subjects who were matched for age and sex. The association between levels of PEDF and clinical, biochemical, and histological phenotypes was examined.
  
  
  RESULTS
  NAFLD patients had significantly higher serum PEDF levels (1.97±0.50 μg/mL) than control subjects (1.51±0.49 μg/mL, Student's t test, P<0.001). Multivariable-adjusted stepwise regression analysis showed that PEDF ([beta]=0.32, t=3.13, P=0.002) and triglycerides ([beta]=0.22, t=2.23, P=0.02) were, in the order they entered into the model, the main independent predictors of steatosis scores in our patients with NAFLD.
  
  
  CONCLUSIONS
  Serum PEDF levels are significantly increased in patients with biopsy-proven NAFLD and are associated with liver steatosis independently of traditional risk factors.
authors: Department of Gastroenterology, Marmara University, School of Medicine, Pendik, 34899 Istanbul, Turkey. yusufyilmaz@uludag.edu.tr
authors: Yusuf
authors: Y
authors: Yilmaz
authors: Fatih
authors: F
authors: Eren
authors: Talat
authors: T
authors: Ayyildiz
authors: Yasar
authors: Y
authors: Colak
authors: Ramazan
authors: R
authors: Kurt
authors: Ebubekir
authors: E
authors: Senates
authors: Ilyas
authors: I
authors: Tuncer
authors: Enver
authors: E
authors: Dolar
authors: Nese
authors: N
authors: Imeryuz
mesh_terms: D000328:Adult; D001706:Biopsy; D005136:Eye Proteins / Q000097:blood*; D005234:Fatty Liver / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009414:Nerve Growth Factors / Q000097:blood*; D065626:Non-alcoholic Fatty Liver Disease; D015203:Reproducibility of Results; D015843:Serpins / Q000097:blood*; D000099174:Pigment Epithelium-Derived Factor
chemical_list: D005136:Eye Proteins; D009414:Nerve Growth Factors; D015843:Serpins; D000099174:Pigment Epithelium-Derived Factor