title: High fat diet induces formation of spontaneous liposarcoma in mouse adipose tissue with overexpression of interleukin 22.
abstract: Interleukin 22 (IL-22) is a T-cell secreted cytokine that modulates inflammatory response in nonhematopoietic tissues such as epithelium and liver. The function of IL-22 in adipose tissue is currently unknown. We generated a transgenic mouse model with overexpression of IL-22 specifically in adipose tissue. The IL-22 transgenic mice had no apparent changes in obesity and insulin resistance after feeding with high fat diet (HFD). Unexpectedly, all the IL-22 transgenic mice fed with HFD for four months developed spontaneous tumors in epididymal adipose tissue. Histological analysis indicated that the tumors were well-differentiated liposarcomas with infiltration of inflammatory cells. IL-22 overexpression promotes production of inflammatory cytokines such as IL-1β and IL-10 and stimulates ERK phosphorylation in adipose tissue. Furthermore, IL-22 treatment in differentiated 3T3-L1 adipocytes could induce IL-1β and IL-10 expression, together with stimulation of ERK phosphorylation. Taken together, our study not only established a novel mouse model with spontaneous liposarcoma, but also revealed that IL-22 overexpression may collaborate with diet-induced obesity to impact on tumor development in mouse.
authors: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China.
authors: Zheng
authors: Z
authors: Wang
authors: Ling
authors: L
authors: Yang
authors: Yuhui
authors: Y
authors: Jiang
authors: Zhi-Qiang
authors: ZQ
authors: Ling
authors: Zhigang
authors: Z
authors: Li
authors: Yuan
authors: Y
authors: Cheng
authors: Heng
authors: H
authors: Huang
authors: Lingdi
authors: L
authors: Wang
authors: Yi
authors: Y
authors: Pan
authors: Zhenzhen
authors: Z
authors: Wang
authors: Xiaoqiang
authors: X
authors: Yan
authors: Yan
authors: Y
authors: Chen
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D016207:Cytokines / Q000096:biosynthesis; D059305:Diet, High-Fat / Q000009:adverse effects*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D015870:Gene Expression; D007378:Interleukins / Q000235:genetics*; D008080:Liposarcoma / Q000209:etiology / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D010766:Phosphorylation / Q000235:genetics; D000097043:Interleukin-22
chemical_list: D016207:Cytokines; D048049:Extracellular Signal-Regulated MAP Kinases; D007378:Interleukins; D000097043:Interleukin-22