title: Behavior of serous borderline ovarian tumors with and without micropapillary patterns: results of a French multicenter study.
abstract: BACKGROUND
  Behavior of serous borderline ovarian tumors with micropapillary patterns (MP-SBOT) is thought to be worse than those without micropapillary patterns, but few cohort studies have compared epidemiological characteristics, surgical management, and recurrence rates between these two groups.
  
  
  METHODS
  In a French retrospective multicenter study of 475 borderline ovarian tumors (BOT) treated from 1990 to 2009, we studied patients with a serous BOT and treated after 2000 including 20 patients with and 77 patients without micropapillary patterns.
  
  
  RESULTS
  Patients with MP-SBOT were younger (P = 0.01), often asymptomatic (P = 0.04), and with abnormal CA 125 serum levels (P = 0.04). Peritoneal implants were more frequently observed in these patients (P = 0.01); also, they underwent conservative treatment more frequently (P = 0.002), had a higher risk of misdiagnosis with invasive carcinoma by intraoperative histology (P < 0.05), and had more frequent restaging surgery (P = 0.001). No difference in recurrence was noted between the groups. No disease-related mortality was observed.
  
  
  CONCLUSIONS
  Patients with MP-SBOT represent a heterogeneous population in terms of presence of invasive peritoneal implants. Conservative surgery could be a suitable option for MP-SBOT patients without implants and who wish to conserve childbearing potential, without increasing the risk of recurrence.
authors: Department of Gynecology and Obstetrics, University Hospital of Amiens, University of Picardie, Jules Verne, Amiens, France. fauvet.raffaele@chu-amiens.fr
authors: R
authors: R
authors: Fauvet
authors: E
authors: E
authors: Demblocque
authors: P
authors: P
authors: Morice
authors: D
authors: D
authors: Querleu
authors: E
authors: E
authors: Daraï
mesh_terms: D000328:Adult; D018394:CA-125 Antigen / Q000032:analysis; D018284:Cystadenocarcinoma, Serous / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000601:surgery
chemical_list: D018394:CA-125 Antigen