title: Improving the yield of mono-DNA-functionalized gold nanoparticles through dual steric hindrance.
abstract: A novel strategy of dual steric hindrance, which was obtained by Janus modification of gold nanoparticles (Au NPs) and volume exclusion of DNA, was adopted to prepare mono-DNA-modified Au NPs. The yield of mono-DNA-functionalized Au NPs significantly improved from 44 to 70% in the reaction between Au NPs and thiolated DNA. Furthermore, the specificity of mono-DNA-functionalized Au NPs was enhanced from 57 to 95%. The as-prepared Au NPs without postsynthetic treatment showed good controllability in self-assembly fabrication of complex nanostructures.
authors: Key Laboratory of Standardization and Measurement for Nanotechnology, National Center for Nanoscience and Technology, No. 11 Zhongguancun Beiyitiao, Beijing 100190, PR China.
authors: Zhengtao
authors: Z
authors: Li
authors: Enjun
authors: E
authors: Cheng
authors: Wenxiao
authors: W
authors: Huang
authors: Tao
authors: T
authors: Zhang
authors: Zhongqiang
authors: Z
authors: Yang
authors: Dongsheng
authors: D
authors: Liu
authors: Zhiyong
authors: Z
authors: Tang
mesh_terms: D004247:DNA / Q000737:chemistry*; D018076:DNA, Complementary / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*
chemical_list: D018076:DNA, Complementary; D006046:Gold; D004247:DNA