title: Novel estimation of the electrical bioimpedance using the local polynomial method. Application to in vivo real-time myocardium tissue impedance characterization during the cardiac cycle.
abstract: Classical measurements of myocardium tissue electrical impedance for characterizing the morphology of myocardium cells, as well as cell membranes integrity and intra/extra cellular spaces, are based on the frequency-sweep electrical impedance spectroscopy (EIS) technique. In contrast to the frequency-sweep EIS approach, measuring with broadband signals, i.e., multisine excitations, enables to collect, simultaneously, multiple myocardium tissue impedance data in a short measuring time. However, reducing the measuring time makes the measurements to be prone to the influence of the transients introduced by noise and the dynamic time-varying properties of tissue. This paper presents a novel approach for the impedance-frequency-response estimation based on the local polynomial method (LPM). The fast LPM version presented rejects the leakage error's influence on the impedance frequency response when measuring electrical bioimpedance in a short time. The theory is supported by a set of validation measurements. Novel preliminary experimental results obtained from real-time in vivo healthy myocardium tissue impedance characterization within the cardiac cycle using multisine excitation are reported.
authors: Department of Electronic Engineering, Technical University of Catalonia, Barcelona 08034, Spain. benjamin.sanchez@upc.edu
authors: Benjamin
authors: B
authors: Sanchez
authors: Johan
authors: J
authors: Schoukens
authors: Ramon
authors: R
authors: Bragos
authors: Gerd
authors: G
authors: Vandersteen
mesh_terms: D000818:Animals; D058266:Dielectric Spectroscopy / Q000379:methods*; D005260:Female; D006321:Heart / Q000502:physiology*; D008955:Models, Cardiovascular; D012044:Regression Analysis; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted; D059629:Signal-To-Noise Ratio; D013552:Swine