title: Pancreatic anticancer activity of a novel geranylgeranylated coumarin derivative.
abstract: A series of hydroxycoumarin derivatives has been synthesized and evaluated against human pancreatic PANC-1 cancer cells under nutrient-deprived conditions. Several compounds exhibited 100% preferential cytotoxicity at low micromolar concentrations under nutrition starvation, and showed no cytotoxicity under nutrient-rich conditions. In this study, a novel geranylgeranylated ether coumarin derivative 9 was found to exhibit the highest cytotoxic activity of 6.25 μM within 24h. The preferential anti-tumor activity exhibited by compound 9 against PANC-1 under low oxygen and nutrient environment illustrates its great potential as a promising lead structure for the development of novel agents to combat pancreatic cancer.
authors: Department of Chemistry, Wellesley College, Wellesley, MA 02481, USA.
authors: Tehsina
authors: T
authors: Devji
authors: Claire
authors: C
authors: Reddy
authors: Christina
authors: C
authors: Woo
authors: Suresh
authors: S
authors: Awale
authors: Shigetoshi
authors: S
authors: Kadota
authors: Dora
authors: D
authors: Carrico-Moniz
mesh_terms: D000478:Alkylation; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D010179:Pancreas / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D054876:Prenylation
chemical_list: D000970:Antineoplastic Agents; D003374:Coumarins