title: Species assignment and antifungal susceptibilities of black aspergilli recovered from otomycosis cases in Iran.
abstract: Black aspergilli are among the main causative agents of otomycosis worldwide. In this study, the species assignment of black aspergilli isolated from otomycosis cases in Iran was carried out using sequence analysis of part of the calmodulin gene. The results indicate that Aspergillus niger is not the only black Aspergillus species involved in otomycosis cases in Iran: Aspergillus awamori and Aspergillus tubingensis are also able to cause ear infections. Antifungal susceptibility tests were carried out against five antifungal drugs including amphotericin B, fluconazole, itraconazole, ketoconazole and terbinafine. All isolates were highly susceptible to terbinafine, while they exhibited moderate susceptibilities against amphotericin B, fluconazole and ketoconazole. Aspergillus niger and A. awamori were found to have higher minimal inhibitory concentrations for azoles than A. tubingensis, in accordance with previous findings.
authors: Department of Microbiology, Faculty of Science & Informatics, University of Szeged, Szeged, Hungary.
authors: Gyöngyi
authors: G
authors: Szigeti
authors: Ebrahim
authors: E
authors: Sedaghati
authors: Ali Zarei
authors: AZ
authors: Mahmoudabadi
authors: Ali
authors: A
authors: Naseri
authors: Sándor
authors: S
authors: Kocsubé
authors: Csaba
authors: C
authors: Vágvölgyi
authors: János
authors: J
authors: Varga
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000494:pharmacology; D001228:Aspergillosis / Q000382:microbiology*; D001234:Aspergillus niger / Q000145:classification* / Q000187:drug effects* / Q000302:isolation & purification; D002147:Calmodulin / Q000235:genetics; D005260:Female; D005656:Fungal Proteins / Q000235:genetics; D006801:Humans; D007492:Iran; D008297:Male; D008826:Microbial Sensitivity Tests; D059249:Otomycosis / Q000382:microbiology*; D010802:Phylogeny
chemical_list: D000935:Antifungal Agents; D002147:Calmodulin; D005656:Fungal Proteins