title: Immobilized unfolded cytochrome c acts as a catalyst for dioxygen reduction.
abstract: Unfolding turns immobilized cytochrome c into a His-His ligated form endowed with catalytic activity towards O(2), which is absent in the native protein. Dioxygen could be used by naturally occurring unfolded cytochrome c as a substrate for the production of partially reduced oxygen species (PROS) contributing to the cell oxidative stress.
authors: Department of Chemistry, University of Trieste, via Giorgieri 1, I-34127 Trieste, Italy.
authors: Claudio
authors: C
authors: Tavagnacco
authors: Stefano
authors: S
authors: Monari
authors: Antonio
authors: A
authors: Ranieri
authors: Carlo Augusto
authors: CA
authors: Bortolotti
authors: Silvia
authors: S
authors: Peressini
authors: Marco
authors: M
authors: Borsari
mesh_terms: D055162:Biocatalysis; D045304:Cytochromes c / Q000737:chemistry* / Q000378:metabolism*; D004563:Electrochemistry; D004566:Electrodes; D004800:Enzymes, Immobilized / Q000737:chemistry* / Q000378:metabolism*; D005227:Fatty Acids / Q000737:chemistry; D005233:Fatty Alcohols / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*; D058767:Protein Unfolding; D013438:Sulfhydryl Compounds / Q000737:chemistry
chemical_list: C505222:11-mercaptoundecanoic acid; C521238:11-mercaptoundecanol; D004800:Enzymes, Immobilized; D005227:Fatty Acids; D005233:Fatty Alcohols; D013438:Sulfhydryl Compounds; D006046:Gold; D045304:Cytochromes c; D010100:Oxygen