title: Panton-Valentine leukocidin-producing Staphylococcal aureus: report of four siblings.
abstract: Panton-Valentine leukocidin (PVL)-producing Staphylococcus aureus results in leukocyte destruction and tissue necrosis (Pediatric Dermatology 2007;24:401). It can be associated with a spectrum of clinical manifestations that range from localized staphylococcal skin infections to sometimes severe necrotizing pneumonia (Clin Infect Dis 1999;29:1128). We report a case of four siblings, three brothers whose atopic dermatitis was complicated by cutaneous lesions and furunculosis, while their 21-month-old sister had a fatal PVL positive staphylococcal pneumonia.
authors: Department of Dermatology, Galway University Hospital, Galway, Ireland. karaheelan@yahoo.com
authors: Kara
authors: K
authors: Heelan
authors: Annette
authors: A
authors: Murphy
authors: Lesley-Ann
authors: LA
authors: Murphy
mesh_terms: D001427:Bacterial Toxins / Q000096:biosynthesis*; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D004359:Drug Therapy, Combination; D004917:Erythromycin / Q000627:therapeutic use; D005098:Exotoxins / Q000096:biosynthesis*; D017809:Fatal Outcome; D005260:Female; D005436:Floxacillin / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D007494:Ireland; D007956:Leukocidins / Q000096:biosynthesis*; D008297:Male; D016712:Mupirocin / Q000627:therapeutic use; D009549:Nigeria; D011023:Pneumonia, Staphylococcal / Q000175:diagnosis* / Q000188:drug therapy; D012973:Sodium Hypochlorite / Q000627:therapeutic use; D013207:Staphylococcal Skin Infections / Q000175:diagnosis* / Q000188:drug therapy; D013211:Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification* / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin; D005436:Floxacillin; D004917:Erythromycin; D016712:Mupirocin; D012973:Sodium Hypochlorite