title: Acyl hydrazides as peptoid sub-monomers.
abstract: The use of acyl hydrazides as peptoid sub-monomers is investigated. We demonstrate here that azapeptoids derived entirely from acyl hydrazides can be made conveniently and efficiently using standard peptoid sub-monomer chemistry. Structural studies reveal that the main chain amide bond in these molecules predominantly adopts a trans conformation. A high-quality one bead one compound library of tetramers was made by split and pool synthesis and we found that the identity of the molecule on a single bead could be determined by tandem MALDI mass spectrometry.
authors: Department of Chemistry, Scripps Research Institute, Scripps Florida, 130 Scripps Way, #3A2, Jupiter, FL 33458, USA.
authors: Bani Kanta
authors: BK
authors: Sarma
authors: Muhammed
authors: M
authors: Yousufuddin
authors: Thomas
authors: T
authors: Kodadek
mesh_terms: D001372:Aza Compounds / Q000737:chemistry; D006834:Hydrazines / Q000737:chemistry*; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D008995:Monoamine Oxidase / Q000737:chemistry / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000737:chemistry; D034444:Peptoids / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D001372:Aza Compounds; D006834:Hydrazines; D008996:Monoamine Oxidase Inhibitors; D034444:Peptoids; C029424:hydrazine; D008995:Monoamine Oxidase