title: Changes in pro/antioxidant balance in smoking and non-smoking pregnant women with intrauterine growth restriction.
abstract: The aim of this study was to investigate the influence of cigarette smoking on the pro/antioxidant balance in pregnant women with intrauterine growth restriction (IUGR). The studies have shown a 2-fold increase of Cd concentration in blood of women with IUGR in labour and a 10-fold increase in smoking pregnant women with IUGR. The increase of malondialdehyde concentration in plasma and 8-hydroxydeoxyguanosine in serum and Cu/Zn superoxide dismutase activity in erythrocyte lysate of pregnants with IUGR, reinforced by smoking, was revealed. We observed a decrease in the concentration of glutathione in blood and glutathione peroxidase activity in plasma and in erythrocyte lysate. A 4-fold higher metallothionein concentration in the plasma of women with IUGR in labour suggests that metallothionein may be one of the IUGR markers. Metallothionein concentration was intensified by smoking up to 7-fold in comparison to the controls. The pro/antioxidant balance during pregnancy is significantly affected by smoking.
authors: Department of Biomedical and Environmental Analysis, Wroclaw Medical University, Grunwaldzka 2, 50-355 Wrocław, Poland.
authors: Anna
authors: A
authors: Bizoń
authors: Ewa
authors: E
authors: Milnerowicz-Nabzdyk
authors: Marta
authors: M
authors: Zalewska
authors: Mariusz
authors: M
authors: Zimmer
authors: Halina
authors: H
authors: Milnerowicz
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D000975:Antioxidants / Q000032:analysis; D002104:Cadmium / Q000097:blood; D003300:Copper / Q000097:blood; D003367:Cotinine / Q000097:blood; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000097:blood; D004785:Environmental Pollutants / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005317:Fetal Growth Retardation / Q000097:blood*; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D007854:Lead / Q000097:blood; D008315:Malondialdehyde / Q000097:blood; D008668:Metallothionein / Q000097:blood; D011247:Pregnancy / Q000097:blood*; D012907:Smoking / Q000097:blood*; D013482:Superoxide Dismutase / Q000097:blood; D055815:Young Adult; D015032:Zinc / Q000097:blood
chemical_list: D000975:Antioxidants; D004785:Environmental Pollutants; D002104:Cadmium; D007854:Lead; D008315:Malondialdehyde; D003300:Copper; D000080242:8-Hydroxy-2'-Deoxyguanosine; D008668:Metallothionein; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D003849:Deoxyguanosine; D005978:Glutathione; D015032:Zinc; D003367:Cotinine