title: CSF Aβ₁₋₄₂ levels and glucose metabolism in Alzheimer's disease.
abstract: Glucose dysmetabolism has been consistently associated with an increased risk of cognitive disorders, and brain insulin resistance could play a role in Alzheimer's disease (AD) pathogenesis. Recent evidence suggests that cerebrospinal fluid (CSF) biomarkers may reflect the brain pathology in AD. We have investigated the relationship between CSF concentrations of amyloid-β peptide 1-42 (Aβ₁₋₄₂), total tau, and phosphorylated tau (ptau-181) and plasma and CSF glucose levels in a cohort of 94 newly diagnosed non-diabetics AD patients. We report that CSF Aβ₁₋₄₂ level was inversely associated with CSF to plasma glucose ratio (Spearman's coefficient = -0.27, p = 0.008). This relationship remained after adjustment for age, gender, body mass index, hypertension, and MMSE score (β [SE] of linear regression = -0.93 [0.37], p = 0.01). In stratified analysis, this relationship was observed only in patients who did not carry the apolipoprotein E4 allele. No significant relationship was found between glucose levels and total tau or phosphorylated tau 181. These results support the idea that a link between glucose dysmetabolism and the amyloid pathway may exist in the pathogenesis of AD.
authors: Centre Mémoire de Ressources et de Recherche Paris Nord Ile-de-France, Lariboisière - Fernand Widal Hospital, APHP, University Paris 7-Denis Diderot, Paris, France. julien.dumurgier@lrb.aphp.fr
authors: Julien
authors: J
authors: Dumurgier
authors: Claire
authors: C
authors: Paquet
authors: Katell
authors: K
authors: Peoc'h
authors: Pauline
authors: P
authors: Lapalus
authors: François
authors: F
authors: Mouton-Liger
authors: Sarah
authors: S
authors: Benisty
authors: Stéphanie
authors: S
authors: Chasseigneaux
authors: Hughes
authors: H
authors: Chabriat
authors: Jacques
authors: J
authors: Hugon
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000150:complications*; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000134:cerebrospinal fluid; D044882:Glucose Metabolism Disorders / Q000097:blood / Q000134:cerebrospinal fluid / Q000209:etiology*; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D010446:Peptide Fragments / Q000134:cerebrospinal fluid*; D012044:Regression Analysis; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D016875:tau Proteins / Q000134:cerebrospinal fluid
chemical_list: D016229:Amyloid beta-Peptides; D001786:Blood Glucose; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D016875:tau Proteins; D005947:Glucose