title: [Alzheimer's disease, amyloid peptide and synaptic dysfunction].
abstract: Alzheimer's disease (AD) is the first cause of dementia that leads to insidious and progressive loss of memory and cognitive functions. In the early stages of AD, there is a strong correlation between memory impairment and cortical levels of soluble amyloid-β peptide oligomers (Aβ). It has become clear that Aβ disrupt glutamatergic synaptic function, which in turn may lead to the characteristic cognitive deficits. Conversely, experiments in rodents have conforted the notion that Aβo impairs synaptic transmission and plasticity, and that mouse models with increased production of these oligomers display cognitive impairment. Many studies have attempted to determine the mechanisms by which Aβo disrupt synaptic plasticity and mediate their detrimental effect, but the actual pathways are still poorly understood. Here we review this thriving area of research which aims at understanding the mechanisms of synaptic dysfunction in the early phase of AD, and its consequences on the activity of neural circuits.
authors: Institut interdisciplinaire de neurosciences, Université de Bordeaux, Bordeaux Cedex, France. ahemar@u-bordeaux2.fr
authors: Agnès
authors: A
authors: Hémar
authors: Christophe
authors: C
authors: Mulle
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D053829:Amyloid Precursor Protein Secretases / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000235:genetics / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D000818:Animals; D018698:Glutamic Acid / Q000502:physiology; D006801:Humans; D018782:Maze Learning; D008569:Memory Disorders / Q000209:etiology / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D008959:Models, Neurological; D009473:Neuronal Plasticity; D011499:Protein Processing, Post-Translational; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D013569:Synapses / Q000502:physiology*
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D016194:Receptors, N-Methyl-D-Aspartate; D018698:Glutamic Acid; D053829:Amyloid Precursor Protein Secretases