title: New cembranolides from the Dongsha Atoll soft coral Lobophytum durum.
abstract: Chemical investigations of the Dongsha Atoll soft coral Lobophytum durum resulted in the isolation of five new cembranolides, durumolides M-Q (1-5). The structures of compounds 1-5 were characterized by the interpretation of extensive spectroscopic analysis. Compound 4 exhibited cytotoxicity against P-388 (mouse lymphocytic leukemia) cell line with an ED₅₀ of 3.8 μg/mL. Moreover, compound 5 showed significant antiviral activity against human cytomegalovirus with an IC₅₀ of 5.2 μg/mL.
authors: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
authors: Shi-Yie
authors: SY
authors: Cheng
authors: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
authors: Pei-Wen
authors: PW
authors: Chen
authors: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
authors: Hwa-Pyng
authors: HP
authors: Chen
authors: Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
authors: Shang-Kwei
authors: SK
authors: Wang
authors: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.|Center for Asia-Pacific Ocean Research and Translational Biopharmaceuticals, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
authors: Chang-Yih
authors: CY
authors: Duh
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D045744:Cell Line, Tumor; D003587:Cytomegalovirus / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D051379:Mice
chemical_list: D004224:Diterpenes