title: Synthesis and antiplasmodial activity of streptocyanine/peroxide and streptocyanine/4-aminoquinoline hybrid dyes.
abstract: Two series of streptocyanine dyes incorporating cyclic peroxide or 4-aminoquinoline moieties are prepared and X-ray diffraction structures for three compounds are determined. All hybrid dyes show good antiplasmodial activity (0.06 to 0.66 μM) and are not or are slightly cytotoxic, except 10a.
authors: Laboratoire de Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique (UMR 5068), Université de Toulouse (Université Paul Sabatier), 31062 Toulouse Cedex 9, France.
authors: Marie-Pierre
authors: MP
authors: Maether
authors: Virginie
authors: V
authors: Bernat
authors: Marie
authors: M
authors: Maturano
authors: Christiane
authors: C
authors: André-Barrès
authors: Sonia
authors: S
authors: Ladeira
authors: Alexis
authors: A
authors: Valentin
authors: Henri
authors: H
authors: Vial
authors: Corinne
authors: C
authors: Payrastre
mesh_terms: D000634:Aminoquinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002232:Carbocyanines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D010545:Peroxides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*; D013237:Stereoisomerism; D014709:Vero Cells
chemical_list: D000634:Aminoquinolines; D000962:Antimalarials; D002232:Carbocyanines; D010545:Peroxides; C001920:4-aminoquinoline