title: High prevalence of human bocavirus 2 and its role in childhood acute gastroenteritis in China.
abstract: BACKGROUND
  Acute gastroenteritis (AGE) is one of the leading causes of death in children worldwide. Human bocavirus 2 (HBoV2) was recently identified in stool samples and is involved in the pathogenesis of AGE, but the current data were too limited to clarify this issue.
  
  
  OBJECTIVE
  We conducted a case-control study on 632 children with diarrhea and 162 healthy controls in Lanzhou, China, to assess the role of HBoV2 in gastroenteritis.
  
  
  METHODS
  Viruses known or suspected to be agents of AGE, including RV, HucV, AdV, AstV, and HBoVs, were detected. Viral loads of HBoV2 were quantified by Real-time PCR.
  
  
  RESULTS
  HBoV2 was detected in 129 (20.4%) and 20 (12.3%) of the gastroenteritis and control samples, respectively. The association between HBoV2 and gastroenteritis was weaker (OR = 1.269, CI= 0.704-2.288) than that between gastroenteritis and RV, HucV, AdV, or AstV, as determined by multivariate logistic regression analysis. The data also suggested that infection with HBoV2 did not exacerbate the clinical symptoms of gastroenteritis. Mean HBoV2 viral load in the case and control groups was fewer than 55 copies/ml extract.
  
  
  CONCLUSIONS
  HBoV2 exhibit different epidemiological features from HBoV1 and HBoV3. The data presented herein do not support a causative role for HBoV2 in AGE, despite its high prevalence in stool samples.
authors: Nanjing Children's Hospital, Medical School of Nanjing University, Nanjing 210008, China.
authors: Yu
authors: Y
authors: Jin
authors: Wei-Xia
authors: WX
authors: Cheng
authors: Zi-Qian
authors: ZQ
authors: Xu
authors: Na
authors: N
authors: Liu
authors: Jie-Mei
authors: JM
authors: Yu
authors: Hui-Ying
authors: HY
authors: Li
authors: Miao
authors: M
authors: Jin
authors: Dan-di
authors: DD
authors: Li
authors: Qing
authors: Q
authors: Zhang
authors: Zhao-Jun
authors: ZJ
authors: Duan
mesh_terms: D016022:Case-Control Studies; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics; D005243:Feces / Q000821:virology; D005260:Female; D005759:Gastroenteritis / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D056661:Human bocavirus / Q000145:classification / Q000302:isolation & purification* / Q000472:pathogenicity; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010322:Parvoviridae Infections / Q000175:diagnosis / Q000453:epidemiology / Q000821:virology*; D019562:Viral Load
chemical_list: D004279:DNA, Viral