title: Host response to the presence of Helicobacter spp. DNA in the liver of patients with chronic liver diseases.
abstract: Literature data indicate an association between the presence of Helicobacter spp. in the liver and the development of hepatocellular carcinoma (HCC). However, the role of H. pylori infections in chronic liver diseases (CLD) remains controversial. The aim of this study was to detect Helicobacter spp. DNA in patients with CLD, and to investigate the host response to the presence of the bacterium in the liver. Helicobacter spp. DNA was detected in 59% samples. H.pylori was the most prevalent species (94%). We estimated the expression level of IL-1 and IL-8 genes. The presence of Helicobacter spp. did not have a significant effect on the gene expression of IL-8 and IL-1.
authors: Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, Poland.
authors: Magda
authors: M
authors: Rybicka
authors: Joanna
authors: J
authors: Nakonieczna
authors: Piotr
authors: P
authors: Stalke
authors: Krzysztof Piotr
authors: KP
authors: Bielawski
mesh_terms: D001706:Biopsy; D006528:Carcinoma, Hepatocellular / Q000382:microbiology; D002908:Chronic Disease; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D016998:Helicobacter / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D016481:Helicobacter Infections / Q000453:epidemiology / Q000382:microbiology*; D016480:Helicobacter pylori / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D054884:Host-Pathogen Interactions; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics; D016209:Interleukin-8 / Q000235:genetics; D008107:Liver Diseases / Q000453:epidemiology / Q000382:microbiology*; D008113:Liver Neoplasms / Q000382:microbiology; D011044:Poland / Q000453:epidemiology; D016133:Polymerase Chain Reaction; D012313:RNA / Q000235:genetics; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D017422:Sequence Analysis, DNA
chemical_list: D004269:DNA, Bacterial; D004275:DNA, Ribosomal; D007375:Interleukin-1; D016209:Interleukin-8; D012336:RNA, Ribosomal, 16S; D012313:RNA