title: A model for dynamics of primer extension by eukaryotic DNA primase.
abstract: A mathematical model is proposed for processive primer extension by eukaryotic DNA primase. The model uses available experimental data to predict rate constants for the dynamic behavior of primase activity as a function of NTP concentration. The model also predicts some data such as the binding affinities of the primase for the DNA template and for the RNA primer.
authors: Key Laboratory of Soft Matter Physics and Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China. pxie@aphy.iphy.ac.cn
authors: Ping
authors: P
authors: Xie
mesh_terms: D004247:DNA / Q000235:genetics / Q000378:metabolism; D019915:DNA Primase / Q000378:metabolism*; D056890:Eukaryota / Q000201:enzymology*; D008954:Models, Biological; D009711:Nucleotides / Q000378:metabolism; D021122:Protein Subunits / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism
chemical_list: D009711:Nucleotides; D021122:Protein Subunits; C034477:RNA primers; D012313:RNA; D004247:DNA; D019915:DNA Primase