title: Differential susceptibility to adolescent externalizing trajectories: examining the interplay between CHRM2 and peer group antisocial behavior.
abstract: The present study characterized prototypical patterns of development in self-reported externalizing behavior, between 12 and 22 years of age, within a community sample of 452 genotyped individuals. A Caucasian subset (n = 378) was then examined to determine whether their probabilities of displaying discrete trajectories were differentially associated with CHRM2, a gene implicated in self-regulatory processes across a range of externalizing behaviors, and if affiliating with antisocial peers moderated these associations. Findings indicate that relative to a normative "lower risk" externalizing trajectory, likelihood of membership in two "higher risk" trajectories increased with each additional copy of the minor allelic variant at CHRM2, and that this association was exacerbated among those exposed to higher levels of peer group antisocial behavior.
authors: Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, PO Box 980126, Richmond, VA 23298-0126, USA. slatendresse@vcu.edu
authors: Shawn J
authors: SJ
authors: Latendresse
authors: John E
authors: JE
authors: Bates
authors: Jackson A
authors: JA
authors: Goodnight
authors: Jennifer E
authors: JE
authors: Lansford
authors: John P
authors: JP
authors: Budde
authors: Alison
authors: A
authors: Goate
authors: Kenneth A
authors: KA
authors: Dodge
authors: Gregory S
authors: GS
authors: Pettit
authors: Danielle M
authors: DM
authors: Dick
mesh_terms: D000293:Adolescent; D000483:Alleles; D000987:Antisocial Personality Disorder / Q000235:genetics*; D002648:Child; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D006801:Humans; D007389:Internal-External Control; D008297:Male; D010379:Peer Group; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D043585:Receptor, Muscarinic M2 / Q000235:genetics*; D012932:Social Facilitation; D012933:Social Identification; D055815:Young Adult
chemical_list: C487078:CHRM2 protein, human; D043585:Receptor, Muscarinic M2