title: Recurrent intra-oral herpes simplex 1 infection.
abstract: Human herpes simplex 1 virus (HSV-1) is a DNA virus that has the ability to lie latent and be subsequently re-activated at any point during a patient's life. In the immunocompetent patient, resolution of clinical signs and symptoms usually occurs spontaneously after 14 days. In the immunocompromised patient, healing is often delayed and the effects are much more debilitating. Indications for therapeutic regimes of systemic antiviral treatment are discussed.
  
  
  CONCLUSIONS
  Recurrent oral ulceration caused by HSV-1 may be seen by the general dental practitioner and can cause significant morbidity.
authors: Newcastle Dental Hospital and School, Framlington Place, Newcastle upon Tyne, NE2 4BW, UK.
authors: Suzanne
authors: S
authors: Westley
authors: Robin
authors: R
authors: Seymour
authors: Konrad
authors: K
authors: Staines
mesh_terms: D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000276:immunology; D005260:Female; D018259:Herpesvirus 1, Human / Q000502:physiology*; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008727:Methotrexate / Q000627:therapeutic use; D019226:Oral Ulcer / Q000821:virology; D012008:Recurrence; D013283:Stomatitis, Herpetic / Q000175:diagnosis* / Q000188:drug therapy; D014775:Virus Activation / Q000502:physiology
chemical_list: D000998:Antiviral Agents; D007166:Immunosuppressive Agents; D008727:Methotrexate