title: Understanding the enemy.
abstract: In this issue of Science Translational Medicine, Tanas and colleagues describe a disease-defining genetic alteration for the vascular cancer epithelioid hemangioendothelioma (EHE). The resulting EHE-associated fusion gene encodes an aberrantly expressed putative transcription factor. This molecular information is the latest in a series of genetic discoveries that aid in cancer diagnosis and may pave the way to targeted therapeutic agents.
authors: Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21287, USA. velculescu@jhmi.edu
authors: Victor E
authors: VE
authors: Velculescu
authors: Luis A
authors: LA
authors: Diaz
mesh_terms: D050939:Gene Fusion / Q000235:genetics*; D018323:Hemangioendothelioma, Epithelioid / Q000235:genetics*; D006801:Humans