title: Microfluidic sensing: state of the art fabrication and detection techniques.
abstract: Here we introduce the existing fabrication techniques, detection methods, and related techniques for microfluidic sensing, with an emphasis on the detection techniques. A general survey and comparison of the fabrication techniques were given, including prototyping (hot embossing, inject molding, and soft lithography) and direct fabrication (laser micromachining, photolithography, lithography, and x-ray lithography) techniques. This is followed by an in-depth look at detection techniques: optical, electrochemical, mass spectrometry, as well as nuclear magnetic resonance spectroscopy-based sensing approaches and related techniques. In the end, we highlight several of the most important issues for future work on microfluidic sensing. This article aims at providing a tutorial review with both introductory materials and inspiring information on microfluidic fabrication and sensing for nonspecialists.
authors: Zhejiang University, State Key Lab of Modern Optical Instrumentation, Department of Optical Engineering, Institute of Advanced Nanophotonics, Zheda Road 38, Xihu District, Hangzhou, Zhejiang 310027, China. jingcindywu@126.com
authors: Jing
authors: J
authors: Wu
authors: Min
authors: M
authors: Gu
mesh_terms: D015374:Biosensing Techniques; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods* / Q000639:trends; D055616:Microtechnology; D011327:Printing