title: Inflammation-inducing Th1 and Th17 cells differ in their expression patterns of apoptosis-related molecules.
abstract: Th1 cells are remarkably more susceptible to activation induced cell death than Th17. Here, we compared cultures of these two cell subpopulations for their expression of apoptosis-related molecules when re-exposed to their specific antigen. We also compared the expression of apoptosis-related molecules in the mouse eye with inflammation induced by Th1 or Th17 cells. Using qPCR we found that the mRNA transcript levels of the majority of tested apoptosis-related molecules were higher in the Th1 cultures, and in eyes with Th1-induced inflammation. Apoptotic intrinsic pathway molecules played minor roles in the processes in vitro or in vivo, whereas extrinsic pathway molecules, as well as PD-1, its ligands and Tim3, were heavily involved.
authors: Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892-1857, USA.
authors: Cuiyan
authors: C
authors: Tan
authors: Madhu
authors: M
authors: Ramaswamy
authors: Guangpu
authors: G
authors: Shi
authors: Barbara P
authors: BP
authors: Vistica
authors: Richard M
authors: RM
authors: Siegel
authors: Igal
authors: I
authors: Gery
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D002460:Cell Line; D005128:Eye Diseases / Q000209:etiology / Q000276:immunology; D007249:Inflammation / Q000209:etiology / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D008822:Mice, Transgenic; D018417:Th1 Cells / Q000276:immunology* / Q000378:metabolism*; D058504:Th17 Cells / Q000276:immunology* / Q000378:metabolism*