title: miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity.
abstract: Using quantitative analyses, we identified microRNAs (miRNAs) that were abundantly expressed in visual cortex and that responded to dark rearing and/or monocular deprivation. The most substantially altered miRNA, miR-132, was rapidly upregulated after eye opening and was delayed by dark rearing. In vivo inhibition of miR-132 in mice prevented ocular dominance plasticity in identified neurons following monocular deprivation and affected the maturation of dendritic spines, demonstrating its critical role in the plasticity of visual cortex circuits.
authors: Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
authors: Nikolaos
authors: N
authors: Mellios
authors: Hiroki
authors: H
authors: Sugihara
authors: Jorge
authors: J
authors: Castro
authors: Abhishek
authors: A
authors: Banerjee
authors: Chuong
authors: C
authors: Le
authors: Arooshi
authors: A
authors: Kumar
authors: Benjamin
authors: B
authors: Crawford
authors: Julia
authors: J
authors: Strathmann
authors: Daniela
authors: D
authors: Tropea
authors: Stuart S
authors: SS
authors: Levine
authors: Dieter
authors: D
authors: Edbauer
authors: Mriganka
authors: M
authors: Sur
mesh_terms: D000367:Age Factors; D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D002118:Calcium / Q000378:metabolism; D003423:Critical Period, Psychological; D003624:Darkness; D049229:Dendritic Spines / Q000378:metabolism; D023882:Dominance, Ocular; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects / Q000235:genetics; D020869:Gene Expression Profiling / Q000379:methods; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D008164:Luminescent Proteins / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D035683:MicroRNAs / Q000737:chemistry / Q000235:genetics / Q000494:pharmacology / Q000502:physiology*; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009473:Neuronal Plasticity / Q000235:genetics / Q000502:physiology*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D018408:Patch-Clamp Techniques; D010775:Photic Stimulation / Q000379:methods; D017966:Pyramidal Cells / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D012683:Sensory Deprivation; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics; D014793:Visual Cortex / Q000166:cytology* / Q000502:physiology
chemical_list: D008164:Luminescent Proteins; C546976:MIRN132 microRNA, mouse; D035683:MicroRNAs; D009419:Nerve Tissue Proteins; D002118:Calcium