title: MiR-483-5p controls angiogenesis in vitro and targets serum response factor.
abstract: Angiogenesis, a key factor in ischemic heart disease, is rapidly initiated in response to hypoxic or ischemic conditions. MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs that regulate gene expression at post-transcriptional level. The recent discovery of the involvement of these RNAs in the control of angiogenesis renders them very attractive in the development of new approaches for restoring the angiogenic balance. In the present study, we explored that miR-483-5p, a microRNA embedded in the intron of insulin-like growth factor 2 (Igf2), acts as an endogenous angiogenesis-inhibiting factor. We identified that serum response factor (SRF) is one of miR-483-5p target genes. These findings indicated that the miR-483-5p-SRF pathway may offer a novel strategy for treatment with angiogenesis in ischemic heart disease patients.
authors: Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.
authors: Yu
authors: Y
authors: Qiao
authors: Ning
authors: N
authors: Ma
authors: Xidi
authors: X
authors: Wang
authors: Yang
authors: Y
authors: Hui
authors: Fuyuan
authors: F
authors: Li
authors: Ying
authors: Y
authors: Xiang
authors: Jianying
authors: J
authors: Zhou
authors: Chaoxia
authors: C
authors: Zou
authors: Jianfeng
authors: J
authors: Jin
authors: Guixiang
authors: G
authors: Lv
authors: Hongbo
authors: H
authors: Jin
authors: Xu
authors: X
authors: Gao
mesh_terms: D020413:3' Untranslated Regions; D002460:Cell Line; D042783:Endothelial Cells / Q000166:cytology / Q000502:physiology; D005786:Gene Expression Regulation; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000235:genetics / Q000378:metabolism; D007438:Introns; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D018919:Neovascularization, Physiologic / Q000502:physiology*; D026362:Serum Response Factor / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D020413:3' Untranslated Regions; C548912:MIRN483 microRNA, human; D035683:MicroRNAs; D026362:Serum Response Factor; D007335:Insulin-Like Growth Factor II