title: Palladium-catalyzed reaction of 2-alkynylhalobenzene with 2-alkynylbenzamide: an efficient approach to indeno[1,2-c]azepin-3(2H)-ones.
abstract: A novel and efficient route for rapid access to indeno[1,2-c]azepin-3(2H)-ones is described, which proceeds through a palladium-catalyzed tandem reaction of 2-alkynylhalobenzene with 2-alkynylbenzamide in the presence of PPh(3) or PCy(3). The indeno[1,2-c]azepin-3(2H)-ones which incorporate both indene and unsaturated seven-membered ring lactam skeletons are obtained in good to excellent yields.
authors: Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China.
authors: Yong
authors: Y
authors: Luo
authors: Jie
authors: J
authors: Wu
mesh_terms: D001381:Azepines / Q000737:chemistry*; D001549:Benzamides / Q000737:chemistry*; D001554:Benzene / Q000737:chemistry*; D002384:Catalysis; D010165:Palladium / Q000737:chemistry*
chemical_list: D001381:Azepines; D001549:Benzamides; D010165:Palladium; D001554:Benzene