title: Pluripotent stem cells - a review of the current status in neural regeneration.
abstract: Pharmacological or neurosurgical therapies currently in practice to treat the damage in various neurodegenerative disorders are not efficient in preventing progression or cure of these progressive neurodegenerative processes. Recently, a new approach, cell therapy using stem cell, is being evaluated. However, the use of this therapy in the treatment of these neurological diseases is highly restricted, mainly owing to several technical difficulties and limitations. The strategy of isolation and characterization of neural stem cells from various sources will probably provide a major impetus and open up an interesting, novel therapeutic modality for several neurodegenerative disorders. The high regenerative potential of damaged neural tissues suggests that various embryonic/adult sources serve as a proxy for neural stem cells for cell-based therapy.
authors: Department of Neurosurgery, CARE The Institute of Medical Sciences, Hyderabad, Andhra Pradesh, India. syedpaspala@gmail.com
authors: Syed Ameer Basha
authors: SA
authors: Paspala
authors: T V R K
authors: TV
authors: Murthy
authors: V S
authors: VS
authors: Mahaboob
authors: M A
authors: MA
authors: Habeeb
mesh_terms: D000818:Animals; D064987:Cell- and Tissue-Based Therapy; D006801:Humans; D019636:Neurodegenerative Diseases / Q000601:surgery*; D039904:Pluripotent Stem Cells / Q000502:physiology* / Q000637:transplantation*; D044968:Regenerative Medicine / Q000379:methods*