title: Oxytocin in the rat caudate nucleus influences pain modulation.
abstract: Our previous studies have demonstrated that oxytocin (OXT) in the central nervous system plays a role in pain modulation. Many studies have found that caudate nucleus (CdN) enriches OXT and OXT receptors by the methods of historadioautograph and gene expression. The communication was designed to investigate OXT effect in the rat CdN on pain modulation. The results showed that (1) intra-CdN microinjection of OXT receptor antagonist, desGly-NH(2), d(CH(2))(5)[D-Tyr(2), Thr-sup-4]OVT decreased the pain threshold, whereas the local administration of OXT increased the pain threshold in a dose-dependent manner; (2) OXT receptor antagonist can attenuate the analgesic role induced intra-CdN administration of OXT; and (3) pain stimulation could increase OXT concentration in the CdN perfusion liquid. The data suggested that OXT in the CdN was involved in this pain process via OXT receptors.
authors: College of Pharmacy, Xinxiang Medical University, Xixiang, Henan, China. bcd2009@126.com
authors: Jun
authors: J
authors: Yang
authors: Yan-Juan
authors: YJ
authors: Pan
authors: Ying
authors: Y
authors: Zhao
authors: Pei-Yong
authors: PY
authors: Qiu
authors: Lu
authors: L
authors: Lu
authors: Peng
authors: P
authors: Li
authors: Feng
authors: F
authors: Chen
authors: Xi-Qing
authors: XQ
authors: Yan
authors: Da-Xin
authors: DX
authors: Wang
mesh_terms: D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008845:Microinjections; D010121:Oxytocin / Q000494:pharmacology*; D010146:Pain / Q000378:metabolism*; D010147:Pain Measurement; D017288:Pain Threshold / Q000187:drug effects*; D011863:Radioimmunoassay; D051381:Rats; D017207:Rats, Sprague-Dawley; D018045:Receptors, Oxytocin / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D000700:Analgesics; D018045:Receptors, Oxytocin; D010121:Oxytocin