title: Bioactive glasses as potential radioisotope vectors for in situ cancer therapy: investigating the structural effects of yttrium.
abstract: The incorporation of yttrium in bioactive glasses (BGs) could lead to a new generation of radionuclide vectors for cancer therapy, with high biocompatibility, controlled biodegradability and the ability to enhance the growth of new healthy tissues after the treatment with radionuclides. It is essential to assess whether and to what extent yttrium incorporation affects the favourable properties of the BG matrix: ideally, one would like to combine the high surface reactivity typical of BGs with a slow release of radioactive yttrium. Molecular Dynamics simulations show that, compared to a BG composition with the same silica fraction, incorporation of yttrium results in two opposing effects on the glass durability: a more fragmented silicate network (leading to lower durability) and a stronger yttrium-mediated association between separate silicate fragments (leading to higher durability). The simulations also highlight a high site-selectivity and some clustering of yttrium cations, which are likely linked to the observed slow rate of yttrium released from related Y-BG compositions. Optimisation of yttrium BG compositions for radiotherapy applications thus depends on the delicate balance between these effects.
authors: Department of Chemistry and Thomas Young Centre, University College London, 20 Gordon Street, London, WC1H 0AJ, UK.
authors: Jamieson K
authors: JK
authors: Christie
authors: Jahangir
authors: J
authors: Malik
authors: Antonio
authors: A
authors: Tilocca
mesh_terms: D016503:Drug Delivery Systems; D005898:Glass / Q000737:chemistry*; D056004:Molecular Dynamics Simulation; D015394:Molecular Structure; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy; D011868:Radioisotopes / Q000737:chemistry*; D011877:Radionuclide Imaging; D015019:Yttrium / Q000737:chemistry*
chemical_list: D011868:Radioisotopes; C558454:bioactive SrO-SiO2 glass; D015019:Yttrium