title: Dihydrotestosterone-inducible IL-6 inhibits elongation of human hair shafts by suppressing matrix cell proliferation and promotes regression of hair follicles in mice.
abstract: Autocrine and paracrine factors are produced by balding dermal papilla (DP) cells following dihydrotestosterone (DHT)-driven alterations and are believed to be key factors involved in male pattern baldness. Herein we report that the IL-6 is upregulated in balding DP cells compared with non-balding DP cells. IL-6 was upregulated 3  hours after 10-100  nM DHT treatment, and ELISA showed that IL-6 was secreted from balding DP cells in response to DHT. IL-6 receptor (IL-6R) and glycoprotein 130 (gp130) were expressed in follicular keratinocytes, including matrix cells. Recombinant human IL-6 (rhIL-6) inhibited hair shaft elongation and suppressed proliferation of matrix cells in cultured human hair follicles. Moreover, rhIL-6 injection into the hypodermis of mice during anagen caused premature onset of catagen. Taken together, our data strongly suggest that DHT-inducible IL-6 inhibits hair growth as a paracrine mediator from the DP.
authors: Department of Immunology, Kyungpook National University School of Medicine, Daegu, Korea.
authors: Mi Hee
authors: MH
authors: Kwack
authors: Ji Sup
authors: JS
authors: Ahn
authors: Moon Kyu
authors: MK
authors: Kim
authors: Jung Chul
authors: JC
authors: Kim
authors: Young Kwan
authors: YK
authors: Sung
mesh_terms: D000505:Alopecia / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D000728:Androgens / Q000494:pharmacology; D000818:Animals; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D002478:Cells, Cultured; D050822:Cytokine Receptor gp130 / Q000502:physiology; D020405:Dermis / Q000166:cytology; D013196:Dihydrotestosterone / Q000494:pharmacology*; D005260:Female; D006197:Hair / Q000187:drug effects / Q000254:growth & development*; D018859:Hair Follicle / Q000187:drug effects* / Q000473:pathology* / Q000502:physiology; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D019899:Paracrine Communication / Q000187:drug effects / Q000502:physiology; D012333:RNA, Messenger / Q000378:metabolism; D012535:Scalp / Q000166:cytology; D015854:Up-Regulation / Q000187:drug effects / Q000502:physiology
chemical_list: D000728:Androgens; C508600:IL6 protein, human; D015850:Interleukin-6; D012333:RNA, Messenger; D013196:Dihydrotestosterone; D050822:Cytokine Receptor gp130