title: [The search for a sensor of intracellular sodium involved in pathogenesis of hypertensive disease].
abstract: Na+,K+ ATPase plays the key role in regulation of intracellular concentration of monovalent cations and related functions essential for electrogenesis and the maintenance of cell volume. This review is focused on the new data showing that a long-term increase of the intracellular Na+ level induces expression of early response genes and genes involved in regulation of apoptosis. Results of the studies of the Na+ sensor and its role in pathogenesis of the salt-sensitive form of hypertensive disease are summarized.
authors: S N
authors: SN
authors: Orlov
authors: P
authors: P
authors: Hamet
mesh_terms: D017209:Apoptosis / Q000235:genetics; D048429:Cell Size; D002477:Cells / Q000378:metabolism / Q000473:pathology; D005786:Gene Expression Regulation; D006801:Humans; D006973:Hypertension / Q000378:metabolism / Q000473:pathology; D017136:Ion Transport / Q000235:genetics; D012045:Regulatory Sequences, Nucleic Acid; D015398:Signal Transduction / Q000235:genetics; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase; D014158:Transcription, Genetic
chemical_list: D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase