title: TBX22 and tongue-tie.
abstract: OBJECTIVE
  To resolve if TBX22 mutations cause isolated tongue-tie in the Finnish population.
  
  
  METHODS
  Mutation analysis of the coding region of the TBX22 gene in 50 Finnish isolated tongue-tie patients and 61 control samples.
  
  
  RESULTS
  One putative sequence variation was identified from two male patients, but whether this represents a polymorphism or causative mutation remains unknown.
  
  
  CONCLUSIONS
  Mutations in the coding region of the TBX22 gene are not a major cause of ankyloglossia in the Finnish population and do not explain the sex difference or inheritance of tongue-tie.
authors: Department of Otorhinolaryngology, Helsinki University Central Hospital, PL 220, FIN-00029 HUS, Finland. tuomas.klockars@fimnet.fi
authors: Tuomas
authors: T
authors: Klockars
authors: Suvi
authors: S
authors: Kyttänen
authors: Pekka
authors: P
authors: Ellonen
mesh_terms: D000072676:Ankyloglossia; D004252:DNA Mutational Analysis; D005260:Female; D005387:Finland; D006801:Humans; D008297:Male; D009056:Mouth Abnormalities / Q000235:genetics*; D009154:Mutation / Q000235:genetics; D012737:Sex Factors; D020825:T-Box Domain Proteins / Q000235:genetics*
chemical_list: D020825:T-Box Domain Proteins; C416943:TBX22 protein, human