title: MT1-MMP expression in the odontogenic region of rat incisors undergoing interrupted eruption.
abstract: MT1-MMP (membrane type matrix metalloproteinase-1) has been considered an important membrane-type matrix metalloproteinase involved in the remodeling process in tissue and organ development, including the processes of the tooth and root growth and dental eruption. Therefore, the aims of this study were to evaluate MT1-MMP expression in the odontogenic region, as well as the eruption rate and morphology of the lower-left rat incisor, where the eruption process was interrupted for 14 days by a steel wire attached from the center of the incisor labial face and braced to the first molar. In the interrupted eruption group, the eruption rate was significantly reduced, producing drastic morphological alterations in the tooth germ and socket area. The MT1-MMP expression was widespread in the dental follicle, in both groups studied (normal and interrupted eruption groups); however a significant decrease in immunostaining was observed in the interrupted eruption group. Results indicate that MT1-MMP may have an important role in the process of dental eruption.
authors: Department of Morphology, Faculty Odontology of Piracicaba, State University of Campinas, Piracicaba, SP, Brazil. odonto_nadia@yahoo.com.br
authors: Nádia Fayez
authors: NF
authors: Omar
authors: José Rosa
authors: JR
authors: Gomes
authors: Juliana dos Santos
authors: Jdos S
authors: Neves
authors: Cristiane Ribeiro
authors: CR
authors: Salmon
authors: Pedro Duarte
authors: PD
authors: Novaes
mesh_terms: D000818:Animals; D003795:Dental Sac / Q000166:cytology / Q000254:growth & development; D007180:Incisor / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D008297:Male; D053511:Matrix Metalloproteinase 14 / Q000096:biosynthesis* / Q000235:genetics; D009805:Odontogenesis / Q000235:genetics*; D051381:Rats; D011917:Rats, Inbred Lew; D014078:Tooth Eruption / Q000235:genetics / Q000502:physiology*; D014083:Tooth Germ / Q000166:cytology / Q000254:growth & development
chemical_list: D053511:Matrix Metalloproteinase 14