title: Factors related to pulse wave velocity and augmentation index in chronic hemodialysis patients.
abstract: BACKGROUND
  Augmentation index (AIx) and pulse wave velocity (PWV) are early markers of atherosclerotic vascular changes and also have been shown to be predictive of cardiovascular disease and total mortality. The aim of our study was to evaluate the relationship between PWV and AIx-HR75, which is the corrected form of AIx according to a heart rate of 75 beats/min, echocardiographic parameters and biochemical parameters in chronic hemodialysis (HD) patients.
  
  
  METHODS
  AIx-HR75 and PWV were measured in 556 HD patients by applanation tonometry using the SphygmoCor device.
  
  
  RESULTS
  The mean PWV and AIx-HR75 values of the study group were 10.2 ± 2.4 and 28.4 ± 10.2 m/s. A positive correlation was found between PWV and AIx-HR75 (r = 0.214, p = 0.000). AIx-HR75 correlated with age (r = 0.093, p = 0.028), body surface area (BSA) (r = -0.194, p = 0.000), mean arterial pressure (MAP) (r = 0.335, p = 0.000), pulse pressure (PP) (r = 0.212, p = 0.000), cardiothoracic index (r = 0.155, p = 0.016), and presence of left ventricular hypertrophy (r = 0.152, p = 0.001). PWV correlated with MAP (r = 0.208, p = 0.000), PP (r = 0.098, r = 0.021), left ventricular mass (r = 0.105, p = 0.023), and predialysis sodium level (r = -0.105, p = 0.023). In the multivariate analyses, PWV was associated with MAP (t = 3.78, p = 0.000), presence of diabetes (t = 3.20, p = 0.001), and predialysis sodium level (t = -2.06, p = 0.040), and AIx-HR75 was associated with age (t = 2.48, p = 0.014), female sex (t = 3.98, p = 0.000), BSA (t = -2.15, p = 0.033), and MAP (t = 7.02, p = 0.000).
  
  
  CONCLUSIONS
  There is a strong association between MAP and arterial stiffness parameters in HD patients. We feel that efficient control of blood pressure could lead to reduced arterial stiffness in HD patients.
authors: Department of Internal Medicine, Division of Nephrology, Selçuklu School of Medicine, Seluk University, Konya, Turkey. gulpericelik@gmail.com
authors: Gülperi
authors: G
authors: Celik
authors: Meltem Sezis
authors: MS
authors: Demirci
authors: Murat
authors: M
authors: Tumuklu
authors: Gulay
authors: G
authors: Ascı
authors: Savas
authors: S
authors: Sipahi
authors: Huseyin
authors: H
authors: Toz
authors: Ali
authors: A
authors: Bascı
authors: Ercan
authors: E
authors: Ok
mesh_terms: D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011674:Pulse; D006435:Renal Dialysis