title: Synthesis and antigastric ulcer activity of novel 5-isoproyl-3,8-dimethylazulene derivatives.
abstract: 5-Isoproyl-3,8-dimethylazulene derivatives were synthesized and evaluated for antigastric ulcer activity in vivo. Some of them possess the best activity against gastric ulcer with ulcer index values lower than the drug reference (omeprazole). The structure-activity relationship (SAR) shows that the lipophilic flat structure contributes to quite potent antigastric ulcer activity.
authors: School of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, Si Chuan Province, China.
authors: Lu-Yun
authors: LY
authors: Zhang
authors: Fang
authors: F
authors: Yang
authors: Wan-Qi
authors: WQ
authors: Shi
authors: Ping
authors: P
authors: Zhang
authors: Ying
authors: Y
authors: Li
authors: Shu-Fan
authors: SF
authors: Yin
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D052176:Azulenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D055808:Drug Discovery; D004353:Drug Evaluation, Preclinical; D051379:Mice; D015394:Molecular Structure; D013276:Stomach Ulcer / Q000188:drug therapy; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000897:Anti-Ulcer Agents; D052176:Azulenes; D013449:Sulfonamides