title: Vitamin E decreased the activity of acetylcholinesterase and level of lipid peroxidation in brain of rats exposed to aged and diluted sidestream smoke.
abstract: BACKGROUND
  The biological systems of both smoker and passive smoking suffer changes caused by toxic compounds from cigarette smoke such as inflammation, lipid peroxidation, and deficiency of vitamin E. The aim of the present study was to evaluate the effect of vitamin E on acetylcholinesterase (AChE) activity and the lipid peroxidation level in the brain of rats in the model of exposure to aged and diluted sidestream smoke (ADSS).
  
  
  METHODS
  Adult male Wistar rats (200-300 g) were exposed to ADSS for 4 weeks and treated with vitamin E (50 mg/kg/day) loaded by gavage. In the first, second, third, and fourth weeks, animals were concomitantly exposed to the smoke of 1, 2, 3, and 4 cigarettes/day, respectively. The duration of each exposure was 15 min, daily.
  
  
  RESULTS
  For rats exposed to ADSS, the AChE activity and lipid peroxidation level increased in the striatum, cerebral cortex, and cerebellum. In contrast, the activity of AChE and the level of lipid peroxidation decreased in the smoke group treated with vitamin E.
  
  
  CONCLUSIONS
  The results suggest that the rats exposed to ADSS and treated with vitamin E significantly reduced the raised activity of AChE and level lipid peroxidation from the brain structures studied. The study, therefore, concludes that vitamin E could be considered as a therapeutic agent in this type of exposure.
authors: Department of Chemistry, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria-RS, Brazil.
authors: Gustavo Roberto
authors: GR
authors: Thomé
authors: Rosélia Maria
authors: RM
authors: Spanevello
authors: Alexandre
authors: A
authors: Mazzanti
authors: Amanda Maino
authors: AM
authors: Fiorenza
authors: Marta Maria Medeiros Frescura
authors: MM
authors: Duarte
authors: Sônia Cristina Almeida
authors: SC
authors: da Luz
authors: Maria Ester
authors: ME
authors: Pereira
authors: Vera Maria
authors: VM
authors: Morsch
authors: Maria Rosa Chitolina
authors: MR
authors: Schetinger
authors: Cinthia Melazzo
authors: CM
authors: Mazzanti
mesh_terms: D000110:Acetylcholinesterase / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D003367:Cotinine / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects*; D008168:Lung / Q000473:pathology; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D014028:Tobacco Smoke Pollution; D014810:Vitamin E; D000110:Acetylcholinesterase; D003367:Cotinine