title: High-sensitivity cardiac troponin T in essential hypertension.
abstract: BACKGROUND
  Myocyte injury might be involved in the progression of essential hypertension (EHT) toward heart failure (HF). However, in the absence of high-sensitivity (hs) assay, cardiac troponin T (TnT) in EHT has not been measurable.
  
  
  RESULTS
  We studied 236 consecutive ambulatory patients (mean age=65.5 years; 110 men) with treated EHT (mean systolic blood pressure=134.3 mmHg, mean serum N-terminal pro-B-type natriuretic peptide=86.6 pg/ml) for mean 65.6 months. Patients with a history of HF were excluded. Single and multiple variable analyses were performed in search of clinical correlates of elevated hs-TnT (≥0.003 ng/ml). Serum concentration of hs-TnT was ≥0.003 ng/ml (mean=0.008 ng/ml) in 184 patients. By single variable analysis, age, uric acid, log-transformed N-terminal pro-B-type natriuretic peptide, brachial-ankle pulse wave velocity, Cornell electrocardiographic (ECG) voltage, and number of antihypertensive medications were associated with log-transformed hs-TnT, while hemoglobin and estimated glomerular filtration rate (eGFR) were inversely correlated with log-transformed hs-TnT. By multivariate analysis, age, eGFR and Cornell voltage were independent correlates of log-transformed hs-TnT, even after adjustment for clinical backgrounds including known prognostic biomarkers of EHT.
  
  
  CONCLUSIONS
  hs-TnT was ≥0.003 ng/ml in 78% of patients presenting with treated EHT and independently correlated with age, renal function, and ECG voltage of hypertrophy.
authors: Division of Cardiology, Hyogo Prefecture Amagasaki Hospital, Higashidaimotsucho 1-1-1, Amagasaki, Hyogo 660-0828, Japan. cardioys@kuhp.kyoto-u.ac.jp
authors: Yukihito
authors: Y
authors: Sato
authors: Erika
authors: E
authors: Yamamoto
authors: Takuma
authors: T
authors: Sawa
authors: Keizo
authors: K
authors: Toda
authors: Tomoko
authors: T
authors: Hara
authors: Toshiaki
authors: T
authors: Iwasaki
authors: Hisayoshi
authors: H
authors: Fujiwara
authors: Yoshiki
authors: Y
authors: Takatsu
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D004562:Electrocardiography; D005260:Female; D005919:Glomerular Filtration Rate; D006333:Heart Failure / Q000175:diagnosis; D006801:Humans; D006973:Hypertension / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012680:Sensitivity and Specificity; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D020107:Troponin T