title: Modulation of liver fibrosis by adipokines.
abstract: Hepatic fibrosis is an integrated process triggered by chronic liver damage, leading to the accumulation of extracellular matrix. In patients with chronic liver disease, this process is favored by the presence of obesity or overweight, which are also relevant risk factors for the progression of nonalcoholic steatohepatitis. In this paper, we review the available evidence indicating the modulation of the fibrogenic process by adipokines, a group of cytokines secreted primarily by adipose tissue. In particular, we discuss in detail the role of leptin and adiponectin, which favor and limit the fibrogenic process, respectively. The possible involvement of other recently identified adipokines is also briefly outlined.
authors: Dipartimento di Medicina Interna, University of Florence, Italy. f.marra @ dmi.unifi.it
authors: Fabio
authors: F
authors: Marra
authors: Nadia
authors: N
authors: Navari
authors: Elisa
authors: E
authors: Vivoli
authors: Sara
authors: S
authors: Galastri
authors: Angela
authors: A
authors: Provenzano
mesh_terms: D054392:Adipokines / Q000378:metabolism*; D000273:Adipose Tissue / Q000378:metabolism / Q000473:pathology; D000818:Animals; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D008103:Liver Cirrhosis / Q000378:metabolism* / Q000473:pathology
chemical_list: D054392:Adipokines; D016207:Cytokines