title: Catecholthioether derivatives: preliminary study of in-vitro antimicrobial and antioxidant activities.
abstract: In this research, synthesis, antimicrobial and antioxidant activities of a series of catecholthioethers having benzoxazole and tetrazole moieties are described. Antimicrobial activity was evaluated by minimum inhibitory concentration (MIC) assay. The synthesized compounds were tested in vitro against three Gram-positive bacteria including Staphylococcus aureus (clinical isolated), Staphylococcus aureus ATCC 25922, Enterococcus faecium (clinical isolated), and two Gram-negative bacteria including Klebsiella pneumoniae (clinical isolated) and Pseudomonas aeruginosa 27853 and the yeast Candida albicans in comparison with control drugs. Microbiological results indicated that the synthesized compounds possessed a broad spectrum of activity against the tested microorganisms at MIC values between 4-256 μg/ml. This shows compounds having tetrazole moiety were the most active against Gram-negative strains, whereas compounds having benzoxazole moiety were more active against Gram-positive ones. Also both of them showed significant antifungal activity against Candida albicans and had lower activity than the compared control drugs (Sulfamethoxazole and Fluconazole). The antioxidant activity was assessed using two methods, including, 1,1-biphenyl-2-picrylhydrazyl (DPPH) radical scavenging, and reducing power assays. Some of the catecholthioether derivatives showed antioxidant activity more than Trolox and butylated hydroxyanisole (BHA) as reference antioxidants.
authors: Department of Medicinal Chemistry, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Iran. hadibi@kums.ac.ir
authors: Hadi
authors: H
authors: Adibi
authors: Atefeh
authors: A
authors: Rashidi
authors: Mohammad Mehdi
authors: MM
authors: Khodaei
authors: Abdolhamid
authors: A
authors: Alizadeh
authors: Mohammad Bagher
authors: MB
authors: Majnooni
authors: Narges
authors: N
authors: Pakravan
authors: Ramin
authors: R
authors: Abiri
authors: Davood
authors: D
authors: Nematollahi
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001583:Benzoxazoles / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000737:chemistry; D002176:Candida albicans / Q000187:drug effects; D004987:Ethers / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010851:Picrates / Q000737:chemistry; D013777:Tetrazoles / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D001583:Benzoxazoles; D001713:Biphenyl Compounds; D004987:Ethers; D010851:Picrates; D013777:Tetrazoles; C004931:1,1-diphenyl-2-picrylhydrazyl