title: A brief survey of mRNA surveillance.
abstract: Defective mRNAs are degraded more rapidly than normal mRNAs in a process called mRNA surveillance. Eukaryotic cells use a variety of mechanisms to detect aberrations in mRNAs and a variety of enzymes to preferentially degrade them. Recent advances in the field of RNA surveillance have provided new information regarding how cells determine which mRNA species should be subject to destruction and novel mechanisms by which a cell tags an mRNA once such a decision has been reached. In this review, we highlight recent progress in our understanding of these processes.
authors: Department of Microbiology and Molecular Genetics, University of Texas Health Science Center-Houston, 6431 Fannin Street, Houston, TX 77030, USA. ambro.van.hoof@uth.tmc.edu
authors: Ambro
authors: A
authors: van Hoof
authors: Eric J
authors: EJ
authors: Wagner
mesh_terms: D000818:Animals; D006801:Humans; D020871:RNA Stability; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger