title: Ovarian gonadoblastoma with dysgerminoma in a 15-year-old girl with 46, XX karyotype: case report and review of the literature.
abstract: OBJECTIVE
  To present a challenging case of hCG positivity in a young patient and to review similar cases reported in the literature.
  
  
  METHODS
  Literature search of gonadoblastoma cases with pure 46, XX karyotype using PubMed database.
  
  
  RESULTS
  A 15-year-old girl with hCG positivity was investigated for the source and the initial diagnosis was an ectopic pregnancy. An ovarian tumor was identified after failed methotrexate therapy and the pathological diagnosis was gonadoblastoma with dysgerminoma. To the best of our knowledge, the case was unique in the literature for having the smallest diameter of a gonadoblastoma tumor with 46, XX karyotype.
  
  
  CONCLUSIONS
  Differential diagnosis of perimenarcheal vaginal bleeding may be challenging for the clinician. Rare causes such as pregnancy both intrauterine and extrauterine and hormone producing tumors should be kept in mind.
authors: Department of Obstetrics and Gynecology, Sami Ulus Maternity and Children's Hospital, 42. Cadde, 18/9 Cukurambar, Ankara, Turkey. sertacesin@gmail.com
authors: Sertac
authors: S
authors: Esin
authors: Eralp
authors: E
authors: Baser
authors: Tuncay
authors: T
authors: Kucukozkan
authors: Hasim Ata
authors: HA
authors: Magden
mesh_terms: D000293:Adolescent; D006063:Chorionic Gonadotropin / Q000097:blood*; D003937:Diagnosis, Differential; D004407:Dysgerminoma / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D005260:Female; D018238:Gonadoblastoma / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D059785:Karyotype; D010051:Ovarian Neoplasms / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000175:diagnosis*; D014592:Uterine Hemorrhage / Q000209:etiology
chemical_list: D006063:Chorionic Gonadotropin