title: No Association Between GRM3 and Japanese Methamphetamine-Induced Psychosis.
abstract: Several investigations have suggested that abnormalities in glutamate neural transmission play a role in the pathophysiology of psychiatric disorders, including schizophrenia. The metabotropic glutamate 3 receptor (mGluR3) gene was reported to be associated with schizophrenia, and paranoid type schizophrenia has symptoms that are similar to those of methamphetamine-induced psychosis. This suggests that mGluR3 gene (GRM3) is a good candidate gene for the pathogenesis of methamphetamine-induced psychosis. To evaluate the association between GRM3 and methamphetamine-induced psychosis, we conducted a case-control study of Japanese samples (181 methamphetamine-induced psychosis and 232 controls).
  
  
  METHODS
  We selected one functional SNP (rs6465084), reported to be associated with prefrontal brain functioning, for an association analysis. Written informed consent was obtained from each subject. This study was approved by the ethics committees at Fujita Health University, Nagoya University Graduate School of Medicine and each participating member of the Institute of the Japanese Genetics Initiative for Drug Abuse (JGIDA).
  
  
  RESULTS
  We did not detect an association between rs6465084 in GRM3 and Japanese methamphetamine-induced psychosis.
  
  
  CONCLUSIONS
  Our findings suggest that rs6465084 in GRM3 does not play a major role in the pathophysiology of methamphetamine-induced psychosis in the Japanese population. However, because we did not perform an association analysis based on linkage disequilibrium (LD) or a mutation scan of GRM3, a replication study using a larger sample and based on LD may be required for conclusive results.
authors: Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan.
authors: Tomoko
authors: T
authors: Tsunoka
authors: Taro
authors: T
authors: Kishi
authors: Masashi
authors: M
authors: Ikeda
authors: Tsuyoshi
authors: T
authors: Kitajima
authors: Yoshio
authors: Y
authors: Yamanouchi
authors: Yoko
authors: Y
authors: Kinoshita
authors: Kunihiro
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authors: Kawashima
authors: Tomo
authors: T
authors: Okochi
authors: Takenori
authors: T
authors: Okumura
authors: Toshiya
authors: T
authors: Inada
authors: Hiroshi
authors: H
authors: Ujike
authors: Mitsuhiko
authors: M
authors: Yamada
authors: Naohisa
authors: N
authors: Uchimura
authors: Ichiro
authors: I
authors: Sora
authors: Masaomi
authors: M
authors: Iyo
authors: Norio
authors: N
authors: Ozaki
authors: Nakao
authors: N
authors: Iwata