title: Preventive effect of Kaempferia parviflora ethyl acetate extract and its major components polymethoxyflavonoid on metabolic diseases.
abstract: Previously, we reported that rhizome powder of Kaempferia parviflora Wall. Ex. Baker prevented obesity and a range of metabolic diseases. In this study, to clarify which molecular mechanisms and active ingredients of K. parviflora have an anti-obesity effect, we investigated the effect of ethyl acetate extract of K. parviflora (KPE) on TSOD mice, a spontaneously obese Type II diabetes model, and on pancreatic lipase. In the TSOD groups, KPE showed a suppressive effect on body weight increase and visceral fat accumulation and also showed preventive effects on symptoms related to insulin resistance, hypertension and fatty liver. In addition, KPE also suppressed body weight increase and food intake in TSNO mice groups, which served as reference animals, at an early stage of administration. Searching for the ingredients in KPE revealed that KPE contains at least 12 kinds of polymethoxyflavonoid (PMF). Furthermore, KPE and its component PMFs showed an inhibitory effect on pancreatic lipase. The above results suggest that KPE has a preventive effect on obesity and various metabolic diseases. The mechanisms of action probably involve inhibition of pancreatic lipase by the PMFs in KPE.
authors: Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20 Shinmachi Nishitokyo-shi, Tokyo 202-8585, Japan.
authors: Tsutomu
authors: T
authors: Shimada
authors: Takumi
authors: T
authors: Horikawa
authors: Yukinobu
authors: Y
authors: Ikeya
authors: Hirotaka
authors: H
authors: Matsuo
authors: Kaoru
authors: K
authors: Kinoshita
authors: Takaaki
authors: T
authors: Taguchi
authors: Koji
authors: K
authors: Ichinose
authors: Kunio
authors: K
authors: Takahashi
authors: Masaki
authors: M
authors: Aburada
mesh_terms: D000818:Animals; D019440:Anti-Obesity Agents / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D004195:Disease Models, Animal; D002149:Energy Intake / Q000187:drug effects; D005234:Fatty Liver / Q000209:etiology / Q000517:prevention & control*; D005419:Flavonoids / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use*; D006973:Hypertension / Q000209:etiology / Q000517:prevention & control*; D007333:Insulin Resistance; D050152:Intra-Abdominal Fat / Q000187:drug effects / Q000378:metabolism; D008049:Lipase / Q000037:antagonists & inhibitors; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008820:Mice, Obese; D009765:Obesity / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D027343:Rhizome; D015430:Weight Gain / Q000187:drug effects; D030521:Zingiberaceae / Q000737:chemistry*
chemical_list: D019440:Anti-Obesity Agents; D005419:Flavonoids; D010936:Plant Extracts; D008049:Lipase