title: The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology and treatment: a critical review.
abstract: The endogenous opioid system has been implicated in the pathophysiology of alcoholism as it modulates the neurobehavioral effects of alcohol. A variant in the mu opioid receptor gene (OPRM1), the Asn40Asp polymorphism, has received attention as a functional variant that may influence a host of behavioral phenotypes for alcoholism as well as clinical response to opioid antagonists. This paper will review converging lines of evidence on the effect of the Asn40Asp SNP on alcoholism phenotypes, including: (i) genetic association studies; (ii) behavioral studies of alcoholism; (iii) neuroimaging studies; (iv) pharmacogenetic studies and clinical trials; and (v) preclinical animal studies. Together, these lines of research seek to elucidate the effects of this functional polymorphism on alcoholism etiology and treatment response.
authors: Department of Psychology, University of California, Los Angeles, California 90095-1563, USA. lararay@psych.ucla.edu
authors: Lara A
authors: LA
authors: Ray
authors: Christina S
authors: CS
authors: Barr
authors: Julie A
authors: JA
authors: Blendy
authors: David
authors: D
authors: Oslin
authors: David
authors: D
authors: Goldman
authors: Raymond F
authors: RF
authors: Anton
mesh_terms: D000437:Alcoholism / Q000188:drug therapy* / Q000235:genetics* / Q000523:psychology; D000818:Animals; D016739:Behavior, Addictive / Q000235:genetics; D002986:Clinical Trials as Topic; D056726:Genetic Association Studies; D006801:Humans; D009292:Narcotic Antagonists / Q000627:therapeutic use*; D059906:Neuroimaging / Q000379:methods / Q000523:psychology; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D017450:Receptors, Opioid, mu / Q000235:genetics*
chemical_list: D009292:Narcotic Antagonists; C485764:OPRM1 protein, human; D017450:Receptors, Opioid, mu