title: Antithrombotic lipids from Semen Persicae.
abstract: Chemical investigation of Semen Persicae has led to the isolation of decane (1), triolein (2), nonacosanoic acid (3), oleic acid ethyl ester (4), palmitic acid (5), oleic acid (6) and 15,16-dihydroxy-9Z,12Z-octadecadienoic acid 2,3-dihydroxypropyl ester (7). Amongst these, compound 7 is a new lipid. Their structures were elucidated by chemical and extensive spectral analysis. Their anticoagulative activities were also evaluated in vitro, which showed that petroleum ether extract and compounds 5-6 could significantly prolong thrombin time while methanol extract could obviously inhibit platelet aggregation.
authors: Jiangsu Key Laboratory for TCM Formulae Research, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China.
authors: Nian-Yun
authors: NY
authors: Yang
authors: Li
authors: L
authors: Liu
authors: Wei-Wei
authors: WW
authors: Tao
authors: Jin-Ao
authors: JA
authors: Duan
authors: Xun-Hong
authors: XH
authors: Liu
authors: Su-Ping
authors: SP
authors: Huang
mesh_terms: D000473:Alkanes / Q000302:isolation & purification; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000302:isolation & purification; D005343:Fibrinolytic Agents / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology*; D008297:Male; D015394:Molecular Structure; D009391:Nephelometry and Turbidimetry; D009829:Oleic Acids / Q000302:isolation & purification; D019308:Palmitic Acid / Q000302:isolation & purification; D010975:Platelet Aggregation Inhibitors / Q000032:analysis / Q000302:isolation & purification*; D027861:Prunus / Q000737:chemistry*; D011817:Rabbits; D012639:Seeds / Q000737:chemistry*; D013918:Thrombin Time; D014304:Triolein / Q000302:isolation & purification
chemical_list: D000473:Alkanes; D004365:Drugs, Chinese Herbal; D005231:Fatty Acids, Unsaturated; D005343:Fibrinolytic Agents; D009829:Oleic Acids; D010975:Platelet Aggregation Inhibitors; D014304:Triolein; C027369:octadecadienoic acid; D019308:Palmitic Acid; C012867:decane