title: Increasing incidence of invasive Haemophilus influenzae disease in adults, Utah, USA.
abstract: Since the introduction of the Haemophilus influenzae type b vaccine, the incidence of invasive H. influenzae type b disease among children has fallen dramatically, but the effect on invasive H. influenzae disease among adults may be more complex. In this population-based study we examined the epidemiology and outcomes of invasive disease caused by typeable and nontypeable H. influenzae among Utah adults during 1998-2008. The overall incidence increased over the study period from 0.14/100,000 person-years in 1998 to 1.61/100,000 person-years in 2008. The average incidence in persons >65 years old was 2.74/100,000 person-years, accounting for 51% of cases and 67% of deaths. The incidence was highest for nontypeable H. influenzae (0.23/100,000 person-years), followed by H. influenzae type f (0.14/100,000 person-years). The case-fatality rate was 22%. The incidence of invasive H. influenzae in Utah adults appears to be increasing. Invasive H. influenzae infection disproportionately affected the elderly and was associated with a high mortality rate.
authors: University of Utah, Salt Lake City, Utah, USA. matthew.rubach@duke.edu
authors: Matthew P
authors: MP
authors: Rubach
authors: Jeffrey M
authors: JM
authors: Bender
authors: Susan
authors: S
authors: Mottice
authors: Kimberly
authors: K
authors: Hanson
authors: Hsin Y C
authors: HY
authors: Weng
authors: Kent
authors: K
authors: Korgenski
authors: Judy A
authors: JA
authors: Daly
authors: Andrew T
authors: AT
authors: Pavia
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016470:Bacteremia / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D006192:Haemophilus Infections / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D006193:Haemophilus influenzae / Q000145:classification / Q000472:pathogenicity*; D006801:Humans; D015994:Incidence; D008583:Meningitis, Haemophilus / Q000453:epidemiology / Q000382:microbiology / Q000401:mortality; D008875:Middle Aged; D012703:Serotyping; D014589:Utah / Q000453:epidemiology; D055815:Young Adult