title: HDAC3 at the fulcrum of an epithelial-mesenchymal balance.
abstract: In this issue of Molecular Cell, Wu et al. (2011) reveal an essential role for a chromatin modifier, histone deacetylase 3 (HDAC3), in hypoxia-induced epithelial-mesenchymal transition (EMT); HIF-activated HDAC3 integrates with WDR5 to impose chromatin modifications that culminate in EMT.
authors: Department of Molecular Pathology, The Center for Stem Cell and Developmental Biology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. smani@mdanderson.org
authors: Sendurai A
authors: SA
authors: Mani
authors: Michelle Craig
authors: MC
authors: Barton