title: Expression of frontotemporal dementia with parkinsonism associated to chromosome 17 tau induces specific degeneration of the ventral dentate gyrus and depressive-like behavior in mice.
abstract: When bearing certain frontotemporal dementia with parkinsonism (FTDP) mutations, overexpression of human tau resulted in a decrease of the dentate gyrus ventral blade, apparently due to a reduction in the proliferation of neuronal precursors and an increase in neuronal cell death. This degenerative process was accompanied by a dramatic increase in behavioral despair, as evident in the Porsolt swim test. Interestingly, we observed an increase in GABAergic innervation in the molecular layer of the dorsal dentate gyrus but not in the ventral domain. We suggest that this increase in GABAergic innervation reflects a compensatory neuroprotective response to the overexpression of toxic tau, which may prevent or delay degeneration in the dorsal blade of the dental gyrus. Finally, we suggest that this transgenic mouse, which overexpresses human FTPD tau, may serve as a useful model to study specific functions of the ventral dentate gyrus.
authors: Centro de Biología Molecular Severo Ochoa (CSIC-UAM), C/Nicolás Cabrera 1, Universidad Autónoma de Madrid, Campus Cantoblanco, 28049 Madrid, Spain.
authors: M
authors: M
authors: Llorens-Martin
authors: F
authors: F
authors: Hernandez
authors: J
authors: J
authors: Avila
mesh_terms: D000818:Animals; D001284:Atrophy / Q000235:genetics / Q000473:pathology; D002452:Cell Count / Q000379:methods / Q000706:statistics & numerical data; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D018891:Dentate Gyrus / Q000473:pathology* / Q000502:physiology; D003863:Depression / Q000235:genetics / Q000473:pathology* / Q000523:psychology*; D004195:Disease Models, Animal; D005260:Female; D057180:Frontotemporal Dementia / Q000235:genetics / Q000473:pathology* / Q000523:psychology*; D059330:GABAergic Neurons / Q000502:physiology; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D057054:Molecular Imaging / Q000379:methods; D009410:Nerve Degeneration / Q000235:genetics / Q000473:pathology*; D055495:Neurogenesis / Q000235:genetics / Q000502:physiology; D016875:tau Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology
chemical_list: D016875:tau Proteins