title: Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
abstract: To identify the genetic bases for nine metabolic traits, we conducted a meta-analysis combining Korean genome-wide association results from the KARE project (n = 8,842) and the HEXA shared control study (n = 3,703). We verified the associations of the loci selected from the discovery meta-analysis in the replication stage (30,395 individuals from the BioBank Japan genome-wide association study and individuals comprising the Health2 and Shanghai Jiao Tong University Diabetes cohorts). We identified ten genome-wide significant signals newly associated with traits from an overall meta-analysis. The most compelling associations involved 12q24.11 (near MYL2) and 12q24.13 (in C12orf51) for high-density lipoprotein cholesterol, 2p21 (near SIX2-SIX3) for fasting plasma glucose, 19q13.33 (in RPS11) and 6q22.33 (in RSPO3) for renal traits, and 12q24.11 (near MYL2), 12q24.13 (in C12orf51 and near OAS1), 4q31.22 (in ZNF827) and 7q11.23 (near TBL2-BCL7B) for hepatic traits. These findings highlight previously unknown biological pathways for metabolic traits investigated in this study.
authors: Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Korea.
authors: Young Jin
authors: YJ
authors: Kim
authors: Min Jin
authors: MJ
authors: Go
authors: Cheng
authors: C
authors: Hu
authors: Chang Bum
authors: CB
authors: Hong
authors: Yun Kyoung
authors: YK
authors: Kim
authors: Ji Young
authors: JY
authors: Lee
authors: Joo-Yeon
authors: JY
authors: Hwang
authors: Ji Hee
authors: JH
authors: Oh
authors: Dong-Joon
authors: DJ
authors: Kim
authors: Nam Hee
authors: NH
authors: Kim
authors: Soeui
authors: S
authors: Kim
authors: Eun Jung
authors: EJ
authors: Hong
authors: Ji-Hyun
authors: JH
authors: Kim
authors: Haesook
authors: H
authors: Min
authors: Yeonjung
authors: Y
authors: Kim
authors: Rong
authors: R
authors: Zhang
authors: Weiping
authors: W
authors: Jia
authors: Yukinori
authors: Y
authors: Okada
authors: Atsushi
authors: A
authors: Takahashi
authors: Michiaki
authors: M
authors: Kubo
authors: Toshihiro
authors: T
authors: Tanaka
authors: Naoyuki
authors: N
authors: Kamatani
authors: Koichi
authors: K
authors: Matsuda
authors: Taesung
authors: T
authors: Park
authors: Bermseok
authors: B
authors: Oh
authors: Kuchan
authors: K
authors: Kimm
authors: Daehee
authors: D
authors: Kang
authors: Chol
authors: C
authors: Shin
authors: Nam H
authors: NH
authors: Cho
authors: Hyung-Lae
authors: HL
authors: Kim
authors: Bok-Ghee
authors: BG
authors: Han
authors: Jong-Young
authors: JY
authors: Lee
authors: Yoon Shin
authors: YS
authors: Cho
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D001786:Blood Glucose / Q000032:analysis / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D008076:Cholesterol, HDL / Q000097:blood / Q000235:genetics; D008078:Cholesterol, LDL / Q000097:blood / Q000235:genetics; D015331:Cohort Studies; D005215:Fasting / Q000097:blood; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D055106:Genome-Wide Association Study; D060005:Genotyping Techniques; D006801:Humans; D007564:Japan; D015810:Linkage Disequilibrium; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D056910:Republic of Korea
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL