title: A simple and efficient route to the FKBP-binding domain from rapamycin.
abstract: A simple and highly efficient route to the FKBP-binding domain (FKBD) from the natural product rapamycin has been developed, which entails a sequence of ozonolysis/Baeyer-Villiger/Wittig reactions. The newly synthesized FKBD may serve as a core to assemble hybrid macrocyclic libraries for the discovery of novel probes of protein function and to synthesize new ligands for the FKBP family of proteins.
authors: Department of Pharmacology, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205.
authors: Wei
authors: W
authors: Li
authors: Shridhar
authors: S
authors: Bhat
authors: Jun O
authors: JO
authors: Liu