title: Antiinflammatory activities of Hungarian Stachys species and their iridoids.
abstract: The antiinflammatory activities of aqueous extracts prepared from the aerial parts of ten Hungarian Stachys species were investigated in vivo in the carrageenan-induced paw oedema test after intraperitoneal and oral administration to rats. Some of the extracts were found to display significant antiphlogistic effects when administered intraperitoneally and orally; in particular, the extracts of S. alpina, S. germanica, S. officinalis and S. recta demonstrated high activity following intraperitoneal administration. At the same dose of 5.0 mg/kg, these extracts exhibited similar or greater potency than that of the positive control diclofenac-Na. The main iridoids present in the investigated extracts, ajugoside, aucubin, acetylharpagide, harpagide and harpagoside, were also assayed in the same test, and high dose-dependent antiphlogistic effects were recorded for aucubin and harpagoside. These results led to the conclusion that most probably iridoids are responsible for the antiinflammatory effect of Stachys species, but other active constituents or their synergism must also be implicated in the antiinflammatory effect.
authors: Department of Pharmacognosy, University of Szeged, Eötvös 6, H-6720, Szeged, Hungary. haznagy.radnai@pharm.u-szeged.hu
authors: Erzsébet
authors: E
authors: Háznagy-Radnai
authors: Ágnes
authors: Á
authors: Balogh
authors: Szilvia
authors: S
authors: Czigle
authors: Imre
authors: I
authors: Máthé
authors: Judit
authors: J
authors: Hohmann
authors: Gábor
authors: G
authors: Blazsó
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002351:Carrageenan / Q000009:adverse effects; D004008:Diclofenac / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D006027:Glycosides / Q000008:administration & dosage / Q000627:therapeutic use*; D007274:Injections, Intraperitoneal; D057888:Iridoid Glucosides / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008517:Phytotherapy; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D011714:Pyrans / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D031366:Stachys / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D006027:Glycosides; D057888:Iridoid Glucosides; D010936:Plant Extracts; D011714:Pyrans; D004008:Diclofenac; C006650:aucubin; C033249:harpagoside; D002351:Carrageenan