title: Synthesis of amino-benzothiaoxazepine-1,1-dioxides utilizing a microwave-assisted, S(N)Ar protocol.
abstract: The development of a microwave-assisted, intermolecular S(N)Ar protocol for the synthesis of a 126-member benzothiaoxazepine-1,1-dioxide library is reported. Diversification of 12 benzothiaoxazepine-1,1-dioxides was achieved in rapid fashion utilizing a variety of 2° amines and amino alcohols to generate an 80-member library. A second 48-member library was subsequently generated via a two-step alkylation, intermolecular S(N)Ar diversification protocol.
authors: Department of Chemistry, University of Kansas, Lawrence, United States.
authors: Alan
authors: A
authors: Rolfe
authors: Farman
authors: F
authors: Ullah
authors: Thiwanka B
authors: TB
authors: Samarakoon
authors: Ryan D
authors: RD
authors: Kurtz
authors: Patrick
authors: P
authors: Porubsky
authors: Benjamin
authors: B
authors: Neuenswander
authors: Gerald H
authors: GH
authors: Lushington
authors: Conrad
authors: C
authors: Santini
authors: Michael G
authors: MG
authors: Organ
authors: Paul R
authors: PR
authors: Hanson
mesh_terms: D000478:Alkylation; D000605:Amino Alcohols / Q000737:chemistry; D001581:Benzothiadiazines / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D008872:Microwaves; D008956:Models, Chemical; D010077:Oxazepines / Q000138:chemical synthesis* / Q000737:chemistry; D010087:Oxides / Q000138:chemical synthesis* / Q000737:chemistry; D013449:Sulfonamides / Q000737:chemistry
chemical_list: D000605:Amino Alcohols; D001581:Benzothiadiazines; D010077:Oxazepines; D010087:Oxides; D013449:Sulfonamides