title: Rye bran alkylresorcinols suppress adipocyte lipolysis and hormone-sensitive lipase activity.
abstract: The effects of alkylresorcinols (ARs) isolated from rye bran on adipocyte lipolysis, hormone-sensitive lipase activity and phosphorylation and on phosphorylation of protein kinase A substrates were studied. Preincubation with ARs for 18 h suppressed catecholamine-stimulated lipolysis in 3T3-L1 adipocytes. Furthermore, phosphorylation of hormone-sensitive lipase (HSL), a key lipase responsible for stimulated lipolysis, and phosphorylation of protein kinase A substrates, were diminished after preincubation with ARs, whereas HSL protein expression was unaltered. ARs were also shown to inhibit HSL activity in an in vitro assay.
authors: Department of Experimental Medical Science, Lund University, Lund, Sweden. ulrika.andersson@med.lu.se
authors: Ulrika
authors: U
authors: Andersson
authors: Estera S
authors: ES
authors: Dey
authors: Cecilia
authors: C
authors: Holm
authors: Eva
authors: E
authors: Degerman
mesh_terms: D041721:3T3-L1 Cells; D017667:Adipocytes / Q000187:drug effects* / Q000378:metabolism*; D000818:Animals; D002395:Catecholamines / Q000494:pharmacology; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D007545:Isoproterenol / Q000494:pharmacology; D008066:Lipolysis / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D010766:Phosphorylation; D012118:Resorcinols / Q000494:pharmacology*; D012434:Secale / Q000737:chemistry*; D002787:Sterol Esterase / Q000378:metabolism*
chemical_list: D002395:Catecholamines; D012118:Resorcinols; D017868:Cyclic AMP-Dependent Protein Kinases; D002787:Sterol Esterase; D007545:Isoproterenol; C031389:resorcinol