title: Antitumor effects of α-bisabolol against pancreatic cancer.
abstract: In the present study, we investigated whether α-bisabolol, a sesquiterpene alcohol present in essential oils derived from a variety of plants, has antitumor effects against pancreatic cancer. α-Bisabolol induced a decrease in cell proliferation and viability in pancreatic cancer cell lines (KLM1, KP4, Panc1, MIA Paca2), but not in pancreatic epithelial cells (ACBRI515). α-Bisabolol treatment induced apoptosis and suppressed Akt activation in pancreatic cancer cell lines. Furthermore, α-bisabolol treatment induced the overexpression of early growth response-1 (EGR1), whereas EGR1 siRNA decreased the α-bisabolol-induced cell death of KLM1 cells. Tumor growth in both subcutaneous and peritoneal xenograft nude mouse models was significantly inhibited by intragastric administration of 1000 mg/kg of α-bisabolol, once a week for three weeks. The results indicate that α-bisabolol could be a novel therapeutic option for the treatment of pancreatic cancer.
authors: Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors: Takashi
authors: T
authors: Seki
authors: Toshio
authors: T
authors: Kokuryo
authors: Yukihiro
authors: Y
authors: Yokoyama
authors: Hisanori
authors: H
authors: Suzuki
authors: Keita
authors: K
authors: Itatsu
authors: Akifumi
authors: A
authors: Nakagawa
authors: Tetsushi
authors: T
authors: Mizutani
authors: Takashi
authors: T
authors: Miyake
authors: Masanori
authors: M
authors: Uno
authors: Kohei
authors: K
authors: Yamauchi
authors: Masato
authors: M
authors: Nagino
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D051766:Early Growth Response Protein 1 / Q000378:metabolism*; D004847:Epithelial Cells / Q000187:drug effects; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D000081222:Monocyclic Sesquiterpenes; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D034622:RNA Interference; D034741:RNA, Small Interfering; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000494:pharmacology*; D023041:Xenograft Model Antitumor Assays
chemical_list: C497325:EGR1 protein, human; D051766:Early Growth Response Protein 1; D000081222:Monocyclic Sesquiterpenes; D010938:Plant Oils; D034741:RNA, Small Interfering; D012717:Sesquiterpenes; C004497:bisabolol; D051057:Proto-Oncogene Proteins c-akt