title: Interferon-β signaling contributes to Ras transformation.
abstract: Increasing evidence has pointed to activated type I interferon signaling in tumors. However, the molecular basis for such activation and its role in tumorigenesis remain unclear. In the current studies, we report that activation of type I interferon (IFN) signaling in tumor cells is primarily due to elevated secretion of the type I interferon, IFN-β. Studies in oncogene-transformed cells suggest that oncogenes such as Ras and Src can activate IFN-β signaling. Significantly, elevated IFN-β signaling in Ras-transformed mammary epithelial MCF-10A cells was shown to contribute to Ras transformation as evidenced by morphological changes, anchorage-independent growth, and migratory properties. Our results demonstrate for the first time that the type I IFN, IFN-β, contributes to Ras transformation and support the notion that oncogene-induced cytokines play important roles in oncogene transformation.
authors: Department of Pharmacology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America.
authors: Yu-Chen
authors: YC
authors: Tsai
authors: Sidney
authors: S
authors: Pestka
authors: Lu-Hai
authors: LH
authors: Wang
authors: Loren W
authors: LW
authors: Runnels
authors: Shan
authors: S
authors: Wan
authors: Yi Lisa
authors: YL
authors: Lyu
authors: Leroy F
authors: LF
authors: Liu
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002465:Cell Movement; D002471:Cell Transformation, Neoplastic; D016207:Cytokines / Q000378:metabolism; D058750:Epithelial-Mesenchymal Transition; D015972:Gene Expression Regulation, Neoplastic; D016391:Genes, src / Q000235:genetics; D006801:Humans; D016899:Interferon-beta / Q000378:metabolism*; D051379:Mice; D041681:NIH 3T3 Cells; D015689:Oncogene Protein p21(ras) / Q000378:metabolism*; D051381:Rats; D015398:Signal Transduction; D014452:Ubiquitins / Q000378:metabolism
chemical_list: D016207:Cytokines; D014452:Ubiquitins; C074034:ISG15 protein, human; D016899:Interferon-beta; D015689:Oncogene Protein p21(ras)