title: Platelet satellitism and dual surface immunoglobulin light-chain expression in circulating splenic marginal zone lymphoma cells.
abstract: Platelet satellitism is believed to be an in vitro phenomenon induced at room temperature in ethylenediamine tetraacetic acid-anticoagulated blood. Most reports involve neutrophils; involvement with circulating lymphoma cells are exceedingly rare. Normally, mature B cells exhibit allelic exclusion in which a single class of surface immunoglobulin light chains (either κ or λ) is expressed. The simultaneous expression of both κ and λ immunoglobulin light chains is rare. Herein, we report the unusual case of a patient with splenic marginal zone lymphoma in which circulating lymphoma cells express dual surface immunoglobulin light chains and exhibit platelet satellitism. In addition to clinical findings, a comprehensive analysis of the peripheral blood including correlated light and electron microscopy as well as flow cytometry are described.
authors: Department of Pathology, Jackson Memorial Hospital/University of Miami Miller School of Medicine, FL 33136, USA. nmontague@med.miami.edu
authors: Naomi
authors: N
authors: Montague
authors: Patricia
authors: P
authors: Blackwelder
authors: Husain
authors: H
authors: Alsayegh
authors: Roberto
authors: R
authors: Ochoa
authors: Ximena
authors: X
authors: Vial
authors: Gerald E
authors: GE
authors: Byrne
mesh_terms: D000369:Aged, 80 and over; D001792:Blood Platelets / Q000473:pathology* / Q000648:ultrastructure; D002448:Cell Adhesion; D017809:Fatal Outcome; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000378:metabolism*; D007146:Immunoglobulin lambda-Chains / Q000378:metabolism*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D009504:Neutrophils / Q000473:pathology* / Q000648:ultrastructure; D013160:Splenic Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure
chemical_list: D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains