title: DNA replication and repair bypass machines.
abstract: Maintenance of genetic stability is of crucial importance for any form of life. Before cell division in each mammalian cell, the process of DNA replication must faithfully duplicate three billion bases with an absolute minimum of mistakes. This is complicated by the fact that DNA itself is highly reactive and is constantly attacked by endogenous and exogenous factors leading to 50,000-100,000 different damages in the DNA of human cells every day. In this mini-review we will focus on lesion bypass by DNA polymerase machines either in replication or repair, with particular focus on the repair of oxidative lesions.
authors: Institute for Veterinary Biochemistry and Molecular Biology, University of Zürich-Irchel, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland. hubscher@vetbio.uzh.ch
authors: Ulrich
authors: U
authors: Hübscher
authors: Giovanni
authors: G
authors: Maga
mesh_terms: D000818:Animals; D002455:Cell Division; D004247:DNA / Q000737:chemistry / Q000235:genetics*; D004249:DNA Damage; D004260:DNA Repair; D004261:DNA Replication / Q000235:genetics*; D004259:DNA-Directed DNA Polymerase / Q000235:genetics / Q000378:metabolism*; D006147:Guanine / Q000031:analogs & derivatives / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism*; D016296:Mutagenesis; D009154:Mutation; D018384:Oxidative Stress; D018809:Proliferating Cell Nuclear Antigen / Q000235:genetics / Q000378:metabolism; D013379:Substrate Specificity
chemical_list: D007527:Isoenzymes; D018809:Proliferating Cell Nuclear Antigen; C024829:8-hydroxyguanine; D006147:Guanine; D004247:DNA; D004259:DNA-Directed DNA Polymerase