title: Myeloperoxidase, but not oxidized LDL, is associated with leisure-time physical activity: results from the MONICA/KORA Augsburg Studies 1984-1995.
abstract: OBJECTIVE
  Oxidative stress-induced cell damage contributes to several chronic conditions such as cardiovascular disease, but only very few population-based studies have examined the influence of regular physical activity (PA) on oxidative stress.
  
  
  METHODS
  1820 men and women aged 35-74 years were randomly drawn from three population-based MONICA/KORA Augsburg Studies conducted between 1984 and 1995. Geometric means of the oxidative stress markers myeloperoxidase (MPO) and oxidized LDL (ox-LDL) were calculated and multiple linear regression was performed to assess their associations with three self-reported PA domains, namely work, leisure-time or walking.
  
  
  RESULTS
  Mean MPO concentrations were lower for participants engaged in high leisure-time PA (124.2 μg/ml; 95%-CI, 116.8-132.0) compared to the inactive reference group (133.5 μg/ml; 95%-CI, 127.6-139.6) (P(trend) across PA levels: 0.007). No significant association between ox-LDL and PA domains was observed (P(trend) between 0.162 and 0.803).
  
  
  CONCLUSIONS
  These data indicate that regular leisure-time PA may reduce MPO concentrations.
authors: Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
authors: Christine S
authors: CS
authors: Autenrieth
authors: Rebecca T
authors: RT
authors: Emeny
authors: Christian
authors: C
authors: Herder
authors: Angela
authors: A
authors: Döring
authors: Annette
authors: A
authors: Peters
authors: Wolfgang
authors: W
authors: Koenig
authors: Barbara
authors: B
authors: Thorand
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D005260:Female; D005858:Germany; D006801:Humans; D007899:Leisure Activities; D016014:Linear Models; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D018384:Oxidative Stress; D009195:Peroxidase / Q000097:blood*; D057566:Self Report; D013997:Time Factors
chemical_list: D015415:Biomarkers; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D009195:Peroxidase