title: Genetic variants in MARCO are associated with the susceptibility to pulmonary tuberculosis in Chinese Han population.
abstract: BACKGROUND
  Susceptibility to tuberculosis is not only determined by Mycobacterium tuberculosis infection, but also by the genetic component of the host. Macrophage receptor with a collagenous structure (MARCO) is essential components required for toll like receptor-signaling in macrophage response to Mycobacterium tuberculosis, which may contribute to tuberculosis risk.
  
  
  RESULTS
  To specifically investigated whether single nucleotide polymorphisms (SNPs) in MARCO gene are associated with pulmonary tuberculosis in Chinese Han population. By selecting tagging SNPs in MARCO gene, 17 tag SNPs were identified and genotyped in 923 pulmonary tuberculosis patients and 1033 healthy control subjects using a hospital based case-control association study. Single-point and haplotype analysis revealed an association in intron and exon region of MARCO gene. One SNP (rs17009726) was associated with susceptibility to pulmonary tuberculosis, where the carriers of the G allele had a 1.65 fold (95% CI = 1.32-2.05, p(corrected) = 9.27E-5) increased risk of pulmonary tuberculosis. Haplotype analysis revealed that haplotype GC containing G allele of 17009726 and haplotype TGCC (rs17795618T/A, rs1371562G/T, rs6761637T/C, rs2011839C/T) were also associated with susceptibility to pulmonary tuberculosis (p(corrected) = 0.0001 and 0.029, respectively).
  
  
  CONCLUSIONS
  Our study suggested that genetic variants in MARCO gene were associated with pulmonary tuberculosis susceptibility in Chinese Han population, and the findings emphasize the importance of MARCO mediated immune responses in the pathogenesis of tuberculosis.
authors: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, People's Republic of China.
authors: Mai-Juan
authors: MJ
authors: Ma
authors: Hai-Bing
authors: HB
authors: Wang
authors: Hao
authors: H
authors: Li
authors: Jun-Hai
authors: JH
authors: Yang
authors: Yan
authors: Y
authors: Yan
authors: Lan-Pin
authors: LP
authors: Xie
authors: Ying-Cheng
authors: YC
authors: Qi
authors: Jun-Lian
authors: JL
authors: Li
authors: Mei-Juan
authors: MJ
authors: Chen
authors: Wei
authors: W
authors: Liu
authors: Wu-Chun
authors: WC
authors: Cao
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology / Q000208:ethnology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis; D020641:Polymorphism, Single Nucleotide; D011971:Receptors, Immunologic / Q000235:genetics*; D012307:Risk Factors; D051193:Toll-Like Receptors; D014397:Tuberculosis, Pulmonary / Q000235:genetics*; D055815:Young Adult
chemical_list: C490460:MARCO protein, human; D011971:Receptors, Immunologic; D051193:Toll-Like Receptors