title: The LOX-1 3'UTR188CT polymorphism and coronary artery disease in Turkish patients.
abstract: In coronary artery disease (CAD), a potentially reversible factor leading to cardiac death is left ventricular hypertrophy (LVH). The 3'untranslated region (3'UTR) 188CT polymorphism of lectin-like oxidized low-density lipoproteins receptor-1 (LOX-1) gene has been associated with an increased risk for CAD. We aim to investigate, in a Turkish population, whether 3'UTR188CT variation could affect the development of LVH in CAD patients. In a population-based case-control study, we compared 83 cases with CAD and 99 healthy controls for this polymorphism. The LOX-1 3'UTR188CT genotypes were determined by PCR-RFLP technique. LOX-1 3'UTR188 TT genotype was associated with significantly increased systolic blood pressure (P = 0.047) and risk of LVH (P = 0.014, OR: 3.541) when compared with the C allele carriers. In addition, the TT genotype was positively associated with decreased levels of HDL-cholesterol in the control subjects (P = 0.031) and increased levels of VLDL-C in the patient group (P = 0.009). The LOX-1 3'UTR188CT gene polymorphism may predispose to the development of LVH in CAD patients, dependent on blood pressure.
authors: Department of Molecular Medicine, The Institute of Experimental Medicine, Istanbul University, Capa, 34390, Istanbul, Turkey.
authors: Ozlem
authors: O
authors: Kurnaz
authors: A Başak
authors: AB
authors: Akadam-Teker
authors: Hülya
authors: H
authors: Yilmaz-Aydoğan
authors: Atike
authors: A
authors: Tekeli
authors: Turgay
authors: T
authors: Isbir
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics*; D000483:Alleles; D001794:Blood Pressure / Q000235:genetics; D015992:Body Mass Index; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications / Q000235:genetics; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D051127:Scavenger Receptors, Class E / Q000235:genetics*; D014421:Turkey
chemical_list: D020413:3' Untranslated Regions; D008074:Lipoproteins; C495137:OLR1 protein, human; D051127:Scavenger Receptors, Class E