title: Simultaneous arterial spin labeling cerebral blood flow and morphological assessments for detection of Alzheimer's disease.
abstract: OBJECTIVE
  The relative roles of arterial spin-labeling (ASL) perfusion imaging and magnetic resonance morphological assessment in diagnosing Alzheimer's disease (AD) have not been established. Our purposes were to directly compare the diagnostic performance of ASL regional cerebral blood flow (rCBF) measurement and that of morphological assessment, and to determine whether or not the combination of the two methods improves diagnostic performance.
  
  
  METHODS
  We analyzed 23 consecutive, retrospectively identified AD patients and 23 healthy control subjects. For each subject, both high-resolution T1-weighted images and ASL perfusion images were obtained. A linear discriminant analysis was performed to distinguish the AD patients from the control subjects based on the three imaging parameters: 1) globally normalized gray matter (GM) density determined by voxel-based morphometry (VBM) procedures, 2) normalized rCBF calculated from ASL data, and 3) the combination of the two. The discriminative abilities of these methods were evaluated by the area under the curve (AUC) derived from receiver-operating characteristics analysis.
  
  
  RESULTS
  The morphological assessment based on the globally normalized GM density resulted in an AUC of 0.779, whereas ASL-normalized rCBF analysis achieved better performance (AUC = 0.893). The combination of the two methods performed better (AUC = 0.919) than either method alone.
  
  
  CONCLUSIONS
  Normalized rCBF measurement by ASL may perform better than morphological analysis based on the VBM procedure in discriminating AD patients from healthy control subjects. The combination of the two approaches was more effective than either method alone.
authors: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
authors: Tuvshinjargal
authors: T
authors: Dashjamts
authors: Takashi
authors: T
authors: Yoshiura
authors: Akio
authors: A
authors: Hiwatashi
authors: Koji
authors: K
authors: Yamashita
authors: Akira
authors: A
authors: Monji
authors: Yasumasa
authors: Y
authors: Ohyagi
authors: Hironori
authors: H
authors: Kamano
authors: Toshiro
authors: T
authors: Kawashima
authors: Jun-Ichi
authors: J
authors: Kira
authors: Hiroshi
authors: H
authors: Honda
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012039:Regional Blood Flow; D012189:Retrospective Studies; D013113:Spin Labels
chemical_list: D013113:Spin Labels