title: Chitosan and silver nanoparticles as pudding with raisins with antimicrobial properties.
abstract: Chitosan nanoparticles (CS-NP) containing small silver nanoparticles are reported (Ag@CS-NP). CS-NP was synthesized using tripolyphosphate (TPP) as a polyanionic template. TPP also served to electrostatically attract Ag(+) inside CS-NP, where it was reduced by the terminal glucosamine units of the biopolymer. This procedure is environmental friendly, inexpensive, and permits the synthesis of very small AgNP (0.93-1.7 nm), with only a discrete dependence from the amount of silver nitrate used (5-200mg). The obtained hybrid nanocomposites Ag@CS-NP were characterized by DLS, HRTEM, and HAADF-STEM presenting a mean hydrodynamic diameter of 78 nm. The antimicrobial activity of Ag@CS-NP against Candida glabrata, Sacharomyces cerevisiae, Escherichia coli, Klebsiella pneumoniae, Salmonella, Staphylococcus aureus, and Bacillus cereus corresponded to MIC values lower than for AgNO(3).
authors: Departamento de Química Inorgánica, Universidade de Vigo, 36310 Vigo, Spain.
authors: M Carmen
authors: MC
authors: Rodríguez-Argüelles
authors: Carmen
authors: C
authors: Sieiro
authors: Roberto
authors: R
authors: Cao
authors: Lucia
authors: L
authors: Nasi
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001409:Bacillus cereus / Q000187:drug effects; D041221:Candida glabrata / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects; D007711:Klebsiella pneumoniae / Q000187:drug effects; D053768:Metal Nanoparticles / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011122:Polyphosphates / Q000737:chemistry; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D012475:Salmonella / Q000187:drug effects; D012834:Silver / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D027843:Vitis / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D009942:Organometallic Compounds; D011122:Polyphosphates; D012834:Silver; D048271:Chitosan; C005692:triphosphoric acid