title: Antigen adsorbed calcium phosphate nanoparticles stimulate both innate and adaptive immune response in fish, Labeo rohita H.
abstract: Calcium phosphate nanoparticles as an antigen/protein delivery was explored in a fish model Labeo rohita H. S-layer protein (of Aeromonas hydrophila) adsorbed on nano sized calcium phosphate particles elicited both innate and adaptive immune parameters which persisted up to 63 days of post immunization through parenteral immunization and gave cross protections.
authors: Fish Health Management Division, Central Institute of Freshwater Aquaculture, Kausalyaganga, Bhubaneswar, Orissa, India.
authors: Truptimayee
authors: T
authors: Behera
authors: Priyabrat
authors: P
authors: Swain
mesh_terms: D056704:Adaptive Immunity; D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000327:Adsorption; D016980:Aeromonas hydrophila / Q000276:immunology* / Q000472:pathogenicity; D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage*; D001426:Bacterial Proteins / Q000008:administration & dosage / Q000276:immunology; D002130:Calcium Phosphates / Q000008:administration & dosage; D002347:Carps / Q000276:immunology* / Q000382:microbiology*; D005393:Fish Diseases / Q000276:immunology / Q000517:prevention & control; D016905:Gram-Negative Bacterial Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary; D007113:Immunity, Innate; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000008:administration & dosage / Q000648:ultrastructure; D014611:Vaccination / Q000662:veterinary*
chemical_list: D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D002130:Calcium Phosphates; C490389:S-layer-encoding structural protein, Aeromonas hydrophila; C020243:calcium phosphate