title: First-in-human pilot study of a spatial frequency domain oxygenation imaging system.
abstract: Oxygenation measurements are widely used in patient care. However, most clinically available instruments currently consist of contact probes that only provide global monitoring of the patient (e.g., pulse oximetry probes) or local monitoring of small areas (e.g., spectroscopy-based probes). Visualization of oxygenation over large areas of tissue, without a priori knowledge of the location of defects, has the potential to improve patient management in many surgical and critical care applications. In this study, we present a clinically compatible multispectral spatial frequency domain imaging (SFDI) system optimized for surgical oxygenation imaging. This system was used to image tissue oxygenation over a large area (16×12 cm) and was validated during preclinical studies by comparing results obtained with an FDA-approved clinical oxygenation probe. Skin flap, bowel, and liver vascular occlusion experiments were performed on Yorkshire pigs and demonstrated that over the course of the experiment, relative changes in oxygen saturation measured using SFDI had an accuracy within 10% of those made using the FDA-approved device. Finally, the new SFDI system was translated to the clinic in a first-in-human pilot study that imaged skin flap oxygenation during reconstructive breast surgery. Overall, this study lays the foundation for clinical translation of endogenous contrast imaging using SFDI.
authors: Beth Israel Deaconess Medical Center, Division of Hematology∕Oncology, Department of Medicine, Boston, Massachusetts 02215, USA.
authors: Sylvain
authors: S
authors: Gioux
authors: Amaan
authors: A
authors: Mazhar
authors: Bernard T
authors: BT
authors: Lee
authors: Samuel J
authors: SJ
authors: Lin
authors: Adam M
authors: AM
authors: Tobias
authors: David J
authors: DJ
authors: Cuccia
authors: Alan
authors: A
authors: Stockdale
authors: Rafiou
authors: R
authors: Oketokoun
authors: Yoshitomo
authors: Y
authors: Ashitate
authors: Edward
authors: E
authors: Kelly
authors: Maxwell
authors: M
authors: Weinmann
authors: Nicholas J
authors: NJ
authors: Durr
authors: Lorissa A
authors: LA
authors: Moffitt
authors: Anthony J
authors: AJ
authors: Durkin
authors: Bruce J
authors: BJ
authors: Tromberg
authors: John V
authors: JV
authors: Frangioni
mesh_terms: D000818:Animals; D004867:Equipment Design; D005260:Female; D041981:Gastrointestinal Tract / Q000098:blood supply; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008099:Liver / Q000098:blood supply; D016462:Mammaplasty; D010092:Oximetry / Q000379:methods*; D010108:Oxyhemoglobins / Q000032:analysis; D010865:Pilot Projects; D015203:Reproducibility of Results; D019265:Spectroscopy, Near-Infrared / Q000295:instrumentation / Q000379:methods*; D025321:Surgery, Computer-Assisted / Q000379:methods*; D013524:Surgical Flaps / Q000098:blood supply; D013552:Swine
chemical_list: D006454:Hemoglobins; D010108:Oxyhemoglobins; C100003:deoxyhemoglobin