title: Maternal preeclampsia is associated with an increased risk of retinopathy of prematurity.
abstract: To determine the effect of maternal preeclampsia on development and severity of retinopathy of prematurity (ROP) in preterm infants.
  
  
  
  This prospective study consisted of two groups: the study group, which is composed of preterm infants (≤32 weeks) born to a mother with preeclampsia, and the comparison group, which is composed of preterm infants (≤32 gestational age) born to normotensive mothers. We used the International Classification of Retinopathy of Prematurity Revisited for classifying ROP. The first eye examination was performed at postnatal age of 4 weeks.
  
  
  
  A total of 385 infants were included in the study. ROP was diagnosed in 109 infants (28%). The incidence of ROP in infants born to preeclamptic mothers (40.5%) was significantly higher compared with those born to normotensive mothers (22.4%) (P<0.05). The number of infants with stage 1, 2, and 3 ROP was significantly higher in infants born to preeclamptic mothers compared with the control group (P<0.05). In multiple logistic regression model, preeclampsia was found to predict ROP (odds ratio 1.78, 95% confidence interval 0.66-1.90).
  
  
  
  Maternal preeclampsia was found to be associated with increased ROP development risk in premature infants. ROP was also more severe in infants born to pre-eclamptic mothers. The role of maternal preeclampsia in the occurrence and severity of ROP remains to be elucidated.
authors: Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Uludag University, Bursa, Turkey.
authors: Hilal
authors: H
authors: Ozkan
authors: Merih
authors: M
authors: Cetinkaya
authors: Nilgun
authors: N
authors: Koksal
authors: Ahmet
authors: A
authors: Ozmen
authors: Meral
authors: M
authors: Yıldız
mesh_terms: D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D061212:Memory, Episodic; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy; D012178:Retinopathy of Prematurity / Q000145:classification / Q000453:epidemiology / Q000209:etiology*; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology