title: Antifungal activity of a series of 1,2-benzisothiazol-3(2H)-one derivatives.
abstract: A series of broad-spectrum antifungal agents based on the 1,2-benzisothiazol-3(2H)-one scaffold is reported. Preliminary structure-activity relationship studies have established the importance of the presence of the heterocyclic ring, a methyl group, and a phenyl ring for optimal manifestation of antifungal activity.
authors: Department of Chemistry, Wichita State University, Wichita, KS 67260, USA.
authors: Dengfeng
authors: D
authors: Dou
authors: Deepu
authors: D
authors: Alex
authors: Bingfan
authors: B
authors: Du
authors: Kok-Chuan
authors: KC
authors: Tiew
authors: Sridhar
authors: S
authors: Aravapalli
authors: Sivakoteswara Rao
authors: SR
authors: Mandadapu
authors: Richard
authors: R
authors: Calderone
authors: William C
authors: WC
authors: Groutas
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects*; D006571:Heterocyclic Compounds / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D006571:Heterocyclic Compounds; D013844:Thiazoles; C015699:1,2-benzisothiazoline-3-one