title: Chip-based drug screening for inhibiting α-glucosidase.
abstract: Intestinal α-glucosidase performs a physiologically vital function in the digestive process of dietary carbohydrates. Administration of an α-glucosidase inhibitor may retard the digestion and absorption of carbohydrates. Consequently, the rise in postprandial blood glucose could be suppressed. This study developed a novel technology, called "after flowing through immobilized receptor (AFTIR)," for targeting components in herbal medicines with α-glucosidase-suppressing capability. As a result, we reveal that the AFTIR system is a highly-efficient drug screening platform, capable of purifying and identifying active components with α-glucosidase-suppressing capability in herbal medicines.
authors: Linsen-Chinese Medicine Branch, Taipei City Hospital, Taipei, Taiwan.
authors: Chung-Chia
authors: CC
authors: Chen
authors: Ping-Hsien
authors: PH
authors: Chuang
authors: Yueh-Sheng
authors: YS
authors: Chen
authors: Chun-Hsu
authors: CH
authors: Yao
authors: Hueih-Min
authors: HM
authors: Chen
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D050260:Carbohydrate Metabolism / Q000187:drug effects*; D004040:Dietary Carbohydrates / Q000378:metabolism*; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors; D029001:Herbal Medicine; D007004:Hypoglycemic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D019518:Postprandial Period
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D010936:Plant Extracts