title: Regio- and enantioselective hydroamination of dienes by gold(I)/menthol cooperative catalysis.
abstract: Alcohol is key: regio- and enantioselective hydroamination of 1,3-dienes has been achieved with the dinuclear catalyst (R)-DTBM-SEGPHOS. The rate and selectivity of the reaction are enhanced by alcohol additives like menthol, which coordinates the cationic gold(I) to generate a Brønsted acid that can participate in catalysis. Mbs=p-methoxybenzenesulfonyl.
authors: Department of Chemistry, University of California Berkeley, 94720, USA.
authors: Osamu
authors: O
authors: Kanno
authors: Wataru
authors: W
authors: Kuriyama
authors: Z Jane
authors: ZJ
authors: Wang
authors: F Dean
authors: FD
authors: Toste
mesh_terms: D000466:Alkadienes / Q000737:chemistry*; D000586:Amination; D002384:Catalysis; D006046:Gold / Q000737:chemistry*; D008610:Menthol / Q000737:chemistry*; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000466:Alkadienes; D010880:Piperidines; D011759:Pyrrolidines; D008610:Menthol; C032727:piperidine; D006046:Gold; C032519:pyrrolidine