title: A compound isolated from Schisandra chinensis induces apoptosis.
abstract: Schizandra chinensis has been known to have five predominant tastes: salty, sweet, sour, astringent, and bitter. It has also been shown to have various effects on the cardiovascular system, gastrointestinal system, anti-inflammatory, central nervous system, endocrine system, and stress protect. However, its anti-cancer activity on colon carcinoma HCT-116 cells has not been yet been examined. Thus, in this study, we attempted to isolate a compound from Schisandra chinensis that induced apoptosis in HCT-116 cells. An active compound was found and identified to be Gomisin A. It displayed apoptotic activity through caspase-7 cleavage in colon carcinoma HCT-116 cells. In addition, we further assessed the effects of this compound using long-term survival clonogenic assay with HCT116 cells.
authors: Division of Bioscience and Biotechnology, BMIC, Konkuk University, Seoul 143-701, Republic of Korea.
authors: Doseok
authors: D
authors: Hwang
authors: Soon Young
authors: SY
authors: Shin
authors: Younggiu
authors: Y
authors: Lee
authors: Jiye
authors: J
authors: Hyun
authors: Yeonjoong
authors: Y
authors: Yong
authors: Jun Cheol
authors: JC
authors: Park
authors: Young Han
authors: YH
authors: Lee
authors: Yoongho
authors: Y
authors: Lim
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D053179:Caspase 7 / Q000378:metabolism; D003110:Colonic Neoplasms / Q000188:drug therapy; D034242:Cyclooctanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004149:Dioxoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D045325:HCT116 Cells; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D032141:Schisandra / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D034242:Cyclooctanes; D004149:Dioxoles; D017705:Lignans; C033585:schizandrol B; D053179:Caspase 7