title: Preserved structural and functional characteristics of common carotid artery in properly treated normoglycemic women with gestational diabetes mellitus.
abstract: Women with gestational diabetes mellitus (GDM) are at high risk of subsequently developing type 2 diabetes mellitus which is an important cardiovascular risk factor. We have evaluated whether preclinical morphological and functional arterial changes are present in GDM. Diameter, intima-media thickness (IMT), intima-media cross-section area (IMCSA) and elasticity features (compliance, distensibility coefficient, circumferential strain, stiffness index (SI) α and β, incremental elastic modulus) of the common carotid arteries (CCA) were studied in the 3rd trimester in 25 women with GDM, and 17 normal pregnant women matched for age and body mass index using an ultrasonographic vessel wall-movement tracking system and applanation tonometry. Mean IMT, IMCSA and SI α tended to be larger, whereas compliance was smaller in women with GDM but none of these differences were significant. Serum glucose (4.99 ± 0.51 vs. 4.79 ± 0.61 mmol/L, p=0.37) and HbA1c (5.33 ± 0.27 vs. 5.36 ± 0.47 mmol/L, p=0.85) proved normoglycemia in both groups. In conclusion, by the combination of methods we applied in this case control study, neither morphological nor functional characteristics of large elastic arteries differ significantly between well-treated normoglycemic women with GDM and non-diabetic pregnant women in the 3rd trimester.
authors: Department of Neurology, Faculty of Medicine, Semmelweis University, Budapest, Hungary. ildiko@neur.sote.hu
authors: Ildikó
authors: I
authors: Vastagh
authors: T
authors: T
authors: Horváth
authors: Z
authors: Z
authors: Garamvölgyi
authors: K
authors: K
authors: Rosta
authors: A
authors: A
authors: Folyovich
authors: J
authors: J
authors: Rigó
authors: M
authors: M
authors: Kollai
authors: D
authors: D
authors: Bereczki
authors: A
authors: A
authors: Somogyi
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D001696:Biomechanical Phenomena; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology*; D016022:Case-Control Studies; D003187:Compliance; D016640:Diabetes, Gestational / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology* / Q000628:therapy; D055119:Elastic Modulus; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D006814:Hungary; D008365:Manometry; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011673:Pulsatile Flow; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology; D014463:Ultrasonography
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human