title: Experience-dependent expression of miR-132 regulates ocular dominance plasticity.
abstract: miR-132 is a CREB-induced microRNA that is involved in dendritic spine plasticity. We found that visual experience regulated histone post-translational modifications at a CRE locus that is important for miR-212 and miR-132 cluster transcription, and regulated miR-132 expression in the visual cortex of juvenile mice. Monocular deprivation reduced miR-132 expression in the cortex contralateral to the deprived eye. Counteracting this miR-132 reduction with an infusion of chemically modified miR-132 mimic oligonucleotides completely blocked ocular dominance plasticity.
authors: Istituto di Neuroscienze Consiglio Nazionale delle Ricerche, Pisa, Italy. tommaso@in.cnr.it
authors: Paola
authors: P
authors: Tognini
authors: Elena
authors: E
authors: Putignano
authors: Alessandro
authors: A
authors: Coatti
authors: Tommaso
authors: T
authors: Pizzorusso
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000367:Age Factors; D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D050882:CREB-Binding Protein / Q000235:genetics / Q000378:metabolism; D047369:Chromatin Immunoprecipitation; D003423:Critical Period, Psychological; D023882:Dominance, Ocular / Q000187:drug effects / Q000502:physiology*; D005074:Evoked Potentials, Visual / Q000187:drug effects; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D049452:Green Fluorescent Proteins / Q000235:genetics; D006657:Histones / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D035683:MicroRNAs / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D041681:NIH 3T3 Cells; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009841:Oligonucleotides / Q000494:pharmacology; D010775:Photic Stimulation / Q000379:methods; D011499:Protein Processing, Post-Translational / Q000502:physiology; D012683:Sensory Deprivation; D014793:Visual Cortex / Q000166:cytology*
chemical_list: D006657:Histones; C546976:MIRN132 microRNA, mouse; C554518:MIRN212 microRNA, mouse; D035683:MicroRNAs; D009841:Oligonucleotides; D049452:Green Fluorescent Proteins; D050882:CREB-Binding Protein