title: Generation and characterization of an Advillin-Cre driver mouse line.
abstract: Progress in the somatosensory field has been restricted by the limited number of genetic tools available to study gene function in peripheral sensory neurons. Here we generated a Cre-driver mouse line that expresses Cre-recombinase from the locus of the sensory neuron specific gene Advillin. These mice displayed almost exclusive Cre-mediated recombination in all peripheral sensory neurons. As such, the Advillin-Cre-driver line will be a powerful tool for targeting peripheral neurons in future investigations.
authors: Mouse Biology Unit, European Molecular Biology Laboratory, Via Ramarini 32, 00016 Monterotondo (Roma), Italy.
authors: Sandra
authors: S
authors: Zurborg
authors: Agnieszka
authors: A
authors: Piszczek
authors: Conception
authors: C
authors: Martínez
authors: Philip
authors: P
authors: Hublitz
authors: Mumna
authors: M
authors: Al Banchaabouchi
authors: Pedro
authors: P
authors: Moreira
authors: Emerald
authors: E
authors: Perlas
authors: Paul A
authors: PA
authors: Heppenstall
mesh_terms: D000375:Aging / Q000378:metabolism; D000818:Animals; D001522:Behavior, Animal; D004622:Embryo, Mammalian / Q000378:metabolism; D018628:Gene Dosage / Q000235:genetics; D005821:Genetic Techniques; D006930:Hyperalgesia / Q000473:pathology / Q000503:physiopathology; D019426:Integrases / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D008840:Microfilament Proteins / Q000378:metabolism*; D059225:Nociception / Q000502:physiology; D011984:Sensory Receptor Cells / Q000378:metabolism; D013194:Staining and Labeling; D001616:beta-Galactosidase / Q000378:metabolism
chemical_list: C113762:Avil protein, mouse; D008840:Microfilament Proteins; C045073:Cre recombinase; D019426:Integrases; D001616:beta-Galactosidase