title: Fatal leptomeningeal melanoma in neurocutaneous melanosis.
abstract: We report an unusual occurrence of a primary dural-based malignant melanoma in a 13-year-old boy with neurocutaneous melanosis. The lesion presented with rapid-onset symptoms characterized by raised intracranial pressure and seizures, had an aggressive clinical course, and proved to be fatal despite two surgeries and adjuvant therapy. There should be a high index of suspicion for the occurrence of such a malignant leptomeningeal tumor in patients with congenital melanocytic nevi presenting with neurological symptoms of recent onset.
authors: Sri Sathya Sai Institute of Higher Medical Sciences, Bangalore, India. shireenseq@gmail.com
authors: Shireen
authors: S
authors: Furtado
authors: Sunil V
authors: SV
authors: Furtado
authors: Nandita
authors: N
authors: Ghosal
authors: Alangar S
authors: AS
authors: Hegde
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003606:Dacarbazine / Q000627:therapeutic use; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008545:Melanoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D008548:Melanosis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D008577:Meningeal Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D020752:Neurocutaneous Syndromes / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D011859:Radiography; D012640:Seizures / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D014750:Vincristine; D003606:Dacarbazine