title: LIF, a Novel STAT5-Regulated Gene, Is Aberrantly Expressed in Myeloproliferative Neoplasms.
abstract: A search for genes potentially regulated by STAT5 identified leukemia inhibitory factor (LIF) as a good candidate. Using various experimental approaches, we have validated LIF as a direct transcriptional target of STAT5 in myeloid cell lines: STAT5 binds to LIF promoter, and LIF expression is increased after activation of the JAK2/STAT5 pathway. We also found that LIF expression is significantly increased in patients with chronic myeloproliferative neoplasms with and without activating mutations of the pathway, indicating that LIF might play an important role in STAT5-mediated oncogenesis.
authors: Department of Genetics, University of Navarra, Pamplona, Spain.
authors: Elisa M
authors: EM
authors: Salas
authors: María J
authors: MJ
authors: García-Barchino
authors: Sara
authors: S
authors: Labiano
authors: Mikhail
authors: M
authors: Shugay
authors: Manuel
authors: M
authors: Pérez-Encinas
authors: Celsa
authors: C
authors: Quinteiro
authors: Marina
authors: M
authors: García-Delgado
authors: José L
authors: JL
authors: Vizmanos
authors: Francisco J
authors: FJ
authors: Novo