title: Central giant cell lesion.
abstract: A classic case of central giant cell lesion (CGCL) is presented with emphasis on clinical, radiologic, and histologic features. The differential is discussed including peripheral giant cell granuloma, brown tumor of hyperparathyroidism, and giant cell tumor of bone. The molecular pathway of osteoclastogenesis is selectively reviewed and applied to suggest possible etiologies of the giant cell lesions. CGCL syndromes and treatment are also discussed.
authors: Department of Anatomic Pathology, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA 92134-5000, USA. james.valentine@med.navy.mil
authors: James C
authors: JC
authors: Valentine
authors: Brenda L
authors: BL
authors: Nelson
mesh_terms: D002454:Cell Differentiation; D003937:Diagnosis, Differential; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology*; D015726:Giant Cells / Q000473:pathology*; D006101:Granuloma, Giant Cell / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D006961:Hyperparathyroidism / Q000175:diagnosis / Q000473:pathology; D008339:Mandibular Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology*; D010010:Osteoclasts / Q000473:pathology; D011859:Radiography; D055815:Young Adult