title: The p75 receptor mediates axon growth inhibition through an association with PIR-B.
abstract: The Nogo receptor and paired immunoglobulin-like receptor B (PIR-B) are receptors for three myelin-derived axon-growth inhibitors, including myelin-associated glycoprotein (MAG). In this study, we report that the p75 receptor is required for the signal transduction of PIR-B, which interacted with p75 upon ligand binding. In addition, p75 was required for activation of Src homology 2-containing protein tyrosine phosphatase (SHP), which is induced by MAG binding to PIR-B. Mice carrying a mutation in the p75 gene showed promotion of axonal regeneration after optic nerve injury. Thus, our results indicate that p75 has a critical role in axon growth inhibition in specific neuronal tracts.
authors: Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors: Y
authors: Y
authors: Fujita
authors: R
authors: R
authors: Takashima
authors: S
authors: S
authors: Endo
authors: T
authors: T
authors: Takai
authors: T
authors: T
authors: Yamashita
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D019556:COS Cells; D002522:Chlorocebus aethiops; D051379:Mice; D008810:Mice, Inbred C57BL; D009154:Mutation; D018992:Myelin-Associated Glycoprotein / Q000378:metabolism; D011485:Protein Binding; D017027:Protein Tyrosine Phosphatases / Q000737:chemistry / Q000378:metabolism; D020800:Receptor, Nerve Growth Factor / Q000235:genetics / Q000378:metabolism*; D020813:Receptor, trkB / Q000378:metabolism; D011971:Receptors, Immunologic / Q000378:metabolism*; D015398:Signal Transduction; D018909:src Homology Domains
chemical_list: D018992:Myelin-Associated Glycoprotein; C105949:Pirb protein, mouse; D020800:Receptor, Nerve Growth Factor; D011971:Receptors, Immunologic; D020813:Receptor, trkB; D017027:Protein Tyrosine Phosphatases