title: On cytoadhesion of Plasmodium vivax: raison d'être?
abstract: It is generally accepted that Plasmodium vivax, the most widely distributed human malaria parasite, causes mild disease and that this species does not sequester in the deep capillaries of internal organs. Recent evidence, however, has demonstrated that there is severe disease, sometimes resulting in death, exclusively associated with P. vivax and that P. vivax-infected reticulocytes are able to cytoadhere in vitro to different endothelial cells and placental cryosections. Here, we review the scarce and preliminary data on cytoadherence in P. vivax, reinforcing the importance of this phenomenon in this species and highlighting the avenues that it opens for our understanding of the pathology of this neglected human malaria parasite.
authors: Departamento de Genética, Evolução e Bioagentes, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brasil. costaftm@unicamp.br
authors: Fabio T M
authors: FT
authors: Costa
authors: Stefanie C P
authors: SC
authors: Lopes
authors: Mireia
authors: M
authors: Ferrer
authors: Juliana A
authors: JA
authors: Leite
authors: Lorena
authors: L
authors: Martin-Jaular
authors: Maria
authors: M
authors: Bernabeu
authors: Paulo A
authors: PA
authors: Nogueira
authors: Maria Paula G
authors: MP
authors: Mourão
authors: Carmen
authors: C
authors: Fernandez-Becerra
authors: Marcus V G
authors: MV
authors: Lacerda
authors: Hernando
authors: H
authors: del Portillo
mesh_terms: D002448:Cell Adhesion; D004912:Erythrocytes / Q000469:parasitology* / Q000502:physiology; D006801:Humans; D016780:Malaria, Vivax / Q000469:parasitology* / Q000473:pathology; D010966:Plasmodium vivax / Q000472:pathogenicity* / Q000502:physiology