title: Hypertension is an independent predictor of mean platelet volume in patients with acute ischaemic stroke.
abstract: BACKGROUND
  Mean platelet volume (MPV) was shown to be significantly increased in patients with acute ischaemic stroke, especially in non-lacunar strokes. Moreover, some studies concluded that increased MPV is related to poor functional outcome after ischaemic stroke, although this association is still controversial. However, the determinants of MPV in patients with acute ischaemic stroke have never been investigated.
  
  
  METHODS
  We recorded the main demographic, clinical and laboratory data of consecutive patients with acute (admitted within 24 h after stroke onset) ischaemic stroke admitted in our Neurology Service between January 2003 and December 2008. MPV was generated at admission by the Sysmex XE-2100 automated cell counter (Sysmex Corporation, Kobe, Japan) from ethylenediaminetetraacetic acid blood samples stored at room temperature until measurement. The association of these parameters with MPV was investigated in univariate and multivariate analysis.
  
  
  RESULTS
  A total of 636 patients was included in our study. The median MPV was 10.4 ± 0.82 fL. In univariate analysis, glucose (β= 0.03, P= 0.05), serum creatinine (β= 0.002, P= 0.02), haemoglobin (β= 0.009, P < 0.001), platelet count (β=-0.002, P < 0.001) and history of arterial hypertension (β= 0.21, P= 0.005) were found to be significantly associated with MPV. In multivariate robust regression analysis, only hypertension and platelet count remained as independent determinants of MPV.
  
  
  CONCLUSIONS
  In patients with acute ischaemic stroke, platelet count and history of hypertension are the only determinants of MPV.
authors: Neurology Service, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland. ntaiosgeorge@yahoo.gr
authors: G
authors: G
authors: Ntaios
authors: O
authors: O
authors: Gurer
authors: M
authors: M
authors: Faouzi
authors: C
authors: C
authors: Aubert
authors: P
authors: P
authors: Michel
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001792:Blood Platelets; D002545:Brain Ischemia / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D010976:Platelet Count / Q000379:methods; D011237:Predictive Value of Tests; D020521:Stroke / Q000097:blood* / Q000175:diagnosis / Q000209:etiology