title: Natriuretic peptides in therapy for decompensated heart failure.
abstract: Congestive heart failure (CHF) is the most frequent cause of hospitalization for patients >65 years of age and continues to be a major public health burden among the ageing population. Unlike therapy for chronic CHF, there has been only modest progress in medical treatment for acutely decompensated CHF over the past several decades. Moreover, current treatment-consisting generally of diuretic, inotropic, and vasodilatory agents-is associated with many limitations in clinical practice. Natriuretic peptides provide a promising mechanism of action in the pathophysiologic background for CHF treatment based on their vasodilatory and diuretic properties and effective inhibition of the renin-angiotensin-aldosterone system, which is activated early in the course of CHF. Nesiritide (Natrecor® or Noratak®) is a recombinant natriuretic peptide that has the same 32 amino-acid sequence as human B-type natriuretic peptide. Nesiritide has been shown to improve dyspnea and hemodynamic parameters in patients with decompensated heart failure. Ularitide is a synthetic form of urodilatin, a natriuretic peptide hormone secreted by the kidney. Recent clinical studies suggest that ularitide may play a role in managing decompensated heart failure. This review provides an update on natriuretic peptides and their therapeutic potential in advanced CHF.
authors: Department of Internal Medicine III, University of Cologne, Cologne, Germany. Natig.Gassanov@uk-koeln.de
authors: Natig
authors: N
authors: Gassanov
authors: Esther
authors: E
authors: Biesenbach
authors: Evren
authors: E
authors: Caglayan
authors: Amir
authors: A
authors: Nia
authors: Uwe
authors: U
authors: Fuhr
authors: Fikret
authors: F
authors: Er
mesh_terms: D006333:Heart Failure / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D045283:Natriuretic Agents / Q000627:therapeutic use*; D045265:Natriuretic Peptides / Q000378:metabolism / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000627:therapeutic use; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D045283:Natriuretic Agents; D045265:Natriuretic Peptides; D011994:Recombinant Proteins; D014665:Vasodilator Agents