title: Effects of Pinus massoniana bark extract on the adhesion and migration capabilities of HeLa cells.
abstract: Pinus massoniana Lamb is a Chinese red pine species used in traditional medicine for the treatment of a variety of human health disorders. Recent studies have shown that P. massoniana bark extract (PMBE) has an anti-proliferation effect on cancer cells. However, it is not clear if PMBE affects cancer cell migration and/or invasion. We tested the effect of PMBE, which has B-type procyanidin as its main constituent, on the adhesion and migration capabilities of HeLa cells, a human cervical cancer cell line, cultured in vitro. Our results showed that PMBE has no significant effect on the adhesion capability of HeLa cells, but strongly inhibits their migration. This finding suggests that PMBE could be a potential therapeutic agent for metastatic cancer.
authors: Department of Regenerative Medicine, Tongji University School of Medicine, Shanghai 200092, China.
authors: Dan-Chen
authors: DC
authors: Wu
authors: Shuai
authors: S
authors: Li
authors: Da-Qing
authors: DQ
authors: Yang
authors: Ying-Yu
authors: YY
authors: Cui
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology / Q000627:therapeutic use*; D044946:Biflavonoids / Q000494:pharmacology / Q000627:therapeutic use*; D002392:Catechin / Q000494:pharmacology / Q000627:therapeutic use*; D002448:Cell Adhesion / Q000187:drug effects*; D002465:Cell Movement / Q000187:drug effects*; D005260:Female; D006367:HeLa Cells; D006801:Humans; D009362:Neoplasm Metastasis / Q000517:prevention & control; D008517:Phytotherapy; D028223:Pinus / Q000737:chemistry*; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D044945:Proanthocyanidins / Q000494:pharmacology / Q000627:therapeutic use*; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D044946:Biflavonoids; D010936:Plant Extracts; D044945:Proanthocyanidins; C479578:procyanidin B; D002392:Catechin