title: Presence of endothelial colony-forming cells is associated with reduced microvascular obstruction limiting infarct size and left ventricular remodelling in patients with acute myocardial infarction.
abstract: Endothelial colony-forming cells (ECFCs) are known to increase after acute myocardial infarction (AMI). We examined whether the presence of ECFCs is associated with preserved microvascular integrity in the myocardium at risk by reducing microvascular obstruction (MVO). We enrolled 88 patients with a first ST elevation AMI. ECFC colonies and circulating progenitor cells were characterized at admission. MVO was evaluated at 5 days and infarct size at 5 days and at 6-month follow-up by magnetic resonance imaging. ECFC colonies were detected in 40 patients (ECFC(pos) patients). At 5 days, MVO was of greater magnitude in ECFC(neg) versus ECFC(pos) patients (7.7 ± 5.3 vs. 3.2 ± 5%, p = 0.0002). At 6 months, in ECFC(pos) patients, there was a greater reduction in infarct size (-32.4 ± 33 vs. -12.8 ± 24%; p = 0.003) and a significant improvement in left ventricular (LV) volumes and ejection fraction. Level of circulating CD34+/VEGF-R2+ cells was correlated with the number of ECFC colonies (r = 0.54, p < 0.001) and relative change in infarct size (r = 0.71, p < 0.0001). The results showed that the presence of ECFC colonies is associated with reduced MVO after AMI, leading to reduced infarct size and less LV remodelling and can be considered a marker of preserved microvascular integrity in AMI patients.
authors: Service de Cardiologie, CHU Besançon, IFR 133, EA 3920, University of Franche-Comté, Besançon, France. nicolas.meneveau@univ-fcomte.fr
authors: Nicolas
authors: N
authors: Meneveau
authors: Frédéric
authors: F
authors: Deschaseaux
authors: Marie-France
authors: MF
authors: Séronde
authors: Romain
authors: R
authors: Chopard
authors: François
authors: F
authors: Schiele
authors: Jérome
authors: J
authors: Jehl
authors: Pierre
authors: P
authors: Tiberghien
authors: Jean-Pierre
authors: JP
authors: Bassand
authors: Jean-Pierre
authors: JP
authors: Kantelip
authors: Siamak
authors: S
authors: Davani
mesh_terms: D003331:Coronary Vessels / Q000166:cytology / Q000473:pathology; D042783:Endothelial Cells / Q000166:cytology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D055806:Microvessels / Q000166:cytology; D008875:Middle Aged; D009203:Myocardial Infarction / Q000473:pathology*; D018919:Neovascularization, Physiologic / Q000502:physiology*; D010641:Phenotype; D013234:Stem Cells / Q000166:cytology*; D020257:Ventricular Remodeling / Q000502:physiology*