title: Synthetic antitumor vaccines containing MUC1 glycopeptides with two immunodominant domains-induction of a strong immune response against breast tumor tissues.
abstract: A shot in the arm for cancer treatment: two MUC1 tetanus toxoid vaccines were synthesized and induced a strong immune response in mice. The antibodies elicited by the vaccines show a high selectivity for the tumor cells in mammary carcinoma tissues and also distinguish between tumor tissues at different stages.
authors: Johannes Gutenberg-Universität Mainz, Germany.
authors: Nikola
authors: N
authors: Gaidzik
authors: Anton
authors: A
authors: Kaiser
authors: Danuta
authors: D
authors: Kowalczyk
authors: Ulrika
authors: U
authors: Westerlind
authors: Bastian
authors: B
authors: Gerlitzki
authors: Hans Peter
authors: HP
authors: Sinn
authors: Edgar
authors: E
authors: Schmitt
authors: Horst
authors: H
authors: Kunz
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000276:immunology / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D019496:Cancer Vaccines / Q000138:chemical synthesis / Q000276:immunology / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006020:Glycopeptides / Q000737:chemistry / Q000276:immunology*; D061986:MCF-7 Cells; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008968:Molecular Conformation; D018396:Mucin-1 / Q000737:chemistry / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000737:chemistry / Q000276:immunology / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D019496:Cancer Vaccines; D006020:Glycopeptides; D018396:Mucin-1; D014614:Vaccines, Synthetic