title: Suzuki-Miyaura cross-coupling of heteroaryl halides and arylboronic acids in continuous flow.
abstract: General continuous-flow conditions for the Suzuki-Miyaura cross-coupling of heteroaryl halides and (hetero)arylboronic acids have been developed. A wide range of heterobiaryl products is obtained in excellent yields (20 examples) employing low catalyst loadings (0.05-1.5 mol % Pd).
authors: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. tnoel@mit.edu
authors: Timothy
authors: T
authors: Noël
authors: Andrew J
authors: AJ
authors: Musacchio
mesh_terms: D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D006219:Halogens / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry; D008024:Ligands; D015394:Molecular Structure
chemical_list: D001897:Boronic Acids; D006219:Halogens; D006571:Heterocyclic Compounds; D008024:Ligands