title: Refractory pediatric nonrhabdomyosarcoma soft tissue sarcoma associated with ectopic production of beta hCG and hypercalcemia induced by PTHrP.
abstract: A 3-month-old male with a mass on the right side of his back was admitted to our hospital. The tumor was a pathologically high-grade nonrhabdomyosarcoma soft tissue sarcoma (NRSTS). Treatment included subtotal tumor resection followed by chemotherapy. Elevation of serum beta hCG and hypercalcemia with detection of PTHrP was associated with tumor progression. The tumor was refractory to multiagent chemotherapy, and the patient died of the disease at 22 months of age. This case is novel in demonstrating a beta hCG secreting refractory NRSTS.
authors: Department of Pediatrics, Tokushima University Hospital, Tokushima, Japan.
authors: Nami
authors: N
authors: Inoue
authors: Hiroyoshi
authors: H
authors: Watanabe
authors: Hiroo
authors: H
authors: Takehara
authors: Minoru
authors: M
authors: Hamazaki
authors: Shoji
authors: S
authors: Kagami
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood*; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D007223:Infant; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D044162:Parathyroid Hormone-Related Protein / Q000097:blood*; D012509:Sarcoma / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D012983:Soft Tissue Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents; D018997:Chorionic Gonadotropin, beta Subunit, Human; D044162:Parathyroid Hormone-Related Protein