title: Association of cognitive performance with interleukin-6 receptor Asp358Ala polymorphism in healthy adults.
abstract: Wechsler adult intelligence scale-revised was performed in 576 healthy adults to examine whether a functional polymorphism (Asp358Ala) of the IL-6 receptor (IL-6R) gene is associated with cognitive performance. Verbal intelligence quotient in Asp homozygotes was significantly higher compared to Ala carriers (P = 0.005). Compared to Ala carriers, Asp homozygotes performed better in the verbal subtests requiring long-term memory stores. Elevated IL-6 and soluble IL-6R levels in Ala carriers may have negative impact on acquiring verbal cognitive ability requiring long-term memory.
authors: Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawahigashi, Kodaira, Tokyo 187-8502, Japan. sasayama@shinshu-u.ac.jp
authors: Daimei
authors: D
authors: Sasayama
authors: Hiroaki
authors: H
authors: Hori
authors: Toshiya
authors: T
authors: Teraishi
authors: Kotaro
authors: K
authors: Hattori
authors: Miho
authors: M
authors: Ota
authors: Junko
authors: J
authors: Matsuo
authors: Yumiko
authors: Y
authors: Kawamoto
authors: Yukiko
authors: Y
authors: Kinoshita
authors: Naoji
authors: N
authors: Amano
authors: Hiroshi
authors: H
authors: Kunugi
mesh_terms: D000328:Adult; D000483:Alleles; D003071:Cognition / Q000502:physiology*; D005260:Female; D005838:Genotype; D006801:Humans; D007360:Intelligence / Q000235:genetics*; D007361:Intelligence Tests; D008297:Male; D008568:Memory / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D020641:Polymorphism, Single Nucleotide; D019947:Receptors, Interleukin-6 / Q000235:genetics*
chemical_list: D019947:Receptors, Interleukin-6; C113250:interleukin-6 receptor alpha