title: Reinvestigation of the C5-acetamide sialic acid donor for α-selective sialylation: practical procedure under microfluidic conditions.
abstract: Despite the previous literature describing the "low-to-modest" efficiency, the readily available C5-acetamide donor was reinvestigated for its use in α-sialylation under microfluidic conditions. The N-phenyltrifluoroacetimidate donor was efficiently mixed with an appropriate amount of TMSOTf to produce the α(2-6) and α(2-3)-sialylation products of galactose and glucosamine acceptors in excellent yields and with nearly perfect α-selectivity.
authors: Department of Chemistry, Graduate School of Science, Osaka University, Osaka, 560-0043, Japan.
authors: Yosuke
authors: Y
authors: Uchinashi
authors: Masahiro
authors: M
authors: Nagasaki
authors: Jiazhou
authors: J
authors: Zhou
authors: Katsunori
authors: K
authors: Tanaka
authors: Koichi
authors: K
authors: Fukase
mesh_terms: D005690:Galactose / Q000737:chemistry; D005944:Glucosamine / Q000737:chemistry; D006900:Hydroxylation; D046210:Microfluidic Analytical Techniques; D015394:Molecular Structure; D019158:N-Acetylneuraminic Acid / Q000737:chemistry*
chemical_list: D019158:N-Acetylneuraminic Acid; D005944:Glucosamine; D005690:Galactose