title: Preventive strategies for central line-associated bloodstream infections in pediatric hematopoietic stem cell transplant recipients.
abstract: BACKGROUND
  Few studies have described preventive strategies for central line-associated bloodstream infections (CLABSIs) in pediatric hematopoietic stem cell transplantation (HSCT) recipients.
  
  
  METHODS
  We performed a pilot intervention study in our pediatric HSCT population in 2006-2008 and compared CLABSI rates before and after implementation of preventive strategies (ie, training staff and caregivers in procedures for dressing changes and drawing blood) in the inpatient, outpatient, and non-health care (ie, home) settings. We also studied the pathogens associated with hospital-onset versus community-onset CLABSIs.
  
  
  RESULTS
  During the study period, 90 children (median age, 10 years) underwent HSCT. Fifty-nine children (66%) developed a CLABSI; 18 in the hospital, 27 in the community, and 14 in both settings. After implementation of central line (CL) maintenance care strategies, the overall CLABSI rate declined from 10.03 to 3.00 CLABSIs per 1,000 CL-days (rate ratio, 0.3; 95% confidence interval, 0.2-0.5, P < .0001) and rates declined for both hospital- and community-onset CLABSIs. Gram negative pathogens caused more community-onset (45/65, 69%) than hospital-onset (22/46, 48%) CLABSIs (odds ratio, 2.5; 95% confidence interval, 1.1-5.4; P = .02).
  
  
  CONCLUSIONS
  Standardization of care practices for CL maintenance was associated with a reduction of CLABSIs in our pediatric HSCT population. A multicenter study is needed to confirm these observations.
authors: Department of Nursing, Morgan Stanley Children's Hospital of New York-Presbyterian, New York-Presbyterian Hospital, New York, NY, USA.
authors: Catherine
authors: C
authors: Barrell
authors: Lisa
authors: L
authors: Covington
authors: Monica
authors: M
authors: Bhatia
authors: Jeff
authors: J
authors: Robison
authors: Sangita
authors: S
authors: Patel
authors: Judith S
authors: JS
authors: Jacobson
authors: Amanda
authors: A
authors: Buet
authors: Philip L
authors: PL
authors: Graham
authors: Lisa
authors: L
authors: Saiman
mesh_terms: D000293:Adolescent; D055499:Catheter-Related Infections / Q000517:prevention & control*; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D007223:Infant; D017053:Infection Control / Q000379:methods*; D008297:Male; D010865:Pilot Projects; D018805:Sepsis / Q000517:prevention & control*