title: Lymphosarcoma associated with Heterobilharzia americana infection in a dog.
abstract: Hepatic T-cell lymphosarcoma with involvement of regional lymph nodes and concurrent schistosomiasis were diagnosed in an 11-year-old male neutered mixed-breed dog with a history of chronic weight loss, inappetence, vomiting, and diarrhea. Trematode ova present in the hepatic parenchyma and mesenteric node were surrounded by sheets of neoplastic lymphocytes while those in the intestinal wall were surrounded by large numbers of non-neoplastic lymphocytes. Immunohistochemistry revealed that both the neoplastic and hyperplastic populations were T lymphocytes. The ova were identified by fecal saline sedimentation as Heterobilharzia spp., and fecal ova shedding resolved after praziquantel anthelmintic treatment. The lymphoma progressed despite chemotherapy, and the dog was euthanized after developing neurologic signs and a necropsy was performed. A monomorphic population of neoplastic T cells expanded and replaced normal architecture in the liver and spleen, surrounded nerve roots within the cauda equina, and infiltrated the meninges of the brain. The presence of schistosome ova embedded within neoplastic T-cell infiltrates suggests that, as previously reported in human schistosomiasis, heterobilharziasis may be associated with neoplasia.
authors: Department of Small Animal Medicine, College of Veterinary Medicine, University of Georgia, 501 DW Brooks Drive, Athens, GA 30602, USA.
authors: Richard H
authors: RH
authors: Stone
authors: Karelma
authors: K
authors: Frontera-Acevedo
authors: Corey F
authors: CF
authors: Saba
authors: Dana
authors: D
authors: Ambrose
authors: Andrew R
authors: AR
authors: Moorhead
authors: Cathy A
authors: CA
authors: Brown
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D004283:Dog Diseases / Q000209:etiology / Q000473:pathology*; D004285:Dogs; D004317:Doxorubicin / Q000627:therapeutic use; D005243:Feces / Q000469:parasitology; D008113:Liver Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D014200:Trematoda / Q000145:classification; D014201:Trematode Infections / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone