title: Light-induced structural and functional plasticity in Drosophila larval visual system.
abstract: How to build and maintain a reliable yet flexible circuit is a fundamental question in neurobiology. The nervous system has the capacity for undergoing modifications to adapt to the changing environment while maintaining its stability through compensatory mechanisms, such as synaptic homeostasis. Here, we describe our findings in the Drosophila larval visual system, where the variation of sensory inputs induced substantial structural plasticity in dendritic arbors of the postsynaptic neuron and concomitant changes to its physiological output. Furthermore, our genetic analyses have identified the cyclic adenosine monophosphate (cAMP) pathway and a previously uncharacterized cell surface molecule as critical components in regulating experience-dependent modification of the postsynaptic dendrite morphology in Drosophila.
authors: Howard Hughes Medical Institute, Department of Physiology and Biochemistry, University of California, San Francisco, 1550 4th Street, San Francisco, CA 94158, USA.
authors: Quan
authors: Q
authors: Yuan
authors: Yang
authors: Y
authors: Xiang
authors: Zhiqiang
authors: Z
authors: Yan
authors: Chun
authors: C
authors: Han
authors: Lily Yeh
authors: LY
authors: Jan
authors: Yuh Nung
authors: YN
authors: Jan
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D000242:Cyclic AMP / Q000378:metabolism; D003624:Darkness; D003712:Dendrites / Q000502:physiology* / Q000648:ultrastructure; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D007814:Larva / Q000502:physiology; D008027:Light; D055537:Light Signal Transduction; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D009473:Neuronal Plasticity; D009474:Neurons / Q000502:physiology / Q000648:ultrastructure; D017956:Photoreceptor Cells, Invertebrate / Q000502:physiology* / Q000648:ultrastructure; D015398:Signal Transduction; D013569:Synapses / Q000502:physiology*; D014795:Visual Pathways
chemical_list: D029721:Drosophila Proteins; D008565:Membrane Proteins; C561197:babos protein, Drosophila; D000242:Cyclic AMP