title: Comparing central retinal thickness in diabetic macular edema measured by two different spectral-domain optical coherence tomography devices.
abstract: OBJECTIVE
  We evaluated central retinal thickness (CRT) in diabetic macular edema (DME) using two different spectral-domain (SD) optical coherence tomography (OCT) instruments: the Cirrus and Spectralis OCTs.
  
  
  METHODS
  CRT was measured in 63 eyes of 32 patients with DME using both instruments on the same day.
  
  
  RESULTS
  CRT measurements were significantly greater for the Spectralis than the Cirrus (p < 0.0003, n = 63, paired t test); mean CRT values were 382 ± 136 μm with the Cirrus and 394 ± 139 μm with the Spectralis. In eyes with poor best-corrected visual acuity (BCVA) (<20/40), mean CRT was 378 ± 130 μm with the Cirrus and 395 ± 139 μm with the Spectralis (p < 0.007, n = 29). In eyes with good acuity (equal to or better than 20/40), the mean CRT was 385 ± 142 μm with the Cirrus and 393 ± 140 μm with the Spectralis (p < 0.005, n = 34).
  
  
  CONCLUSIONS
  Foveal retinal thickness measurements may vary among SD-OCT devices. The differences between instruments could affect the results of a multicenter study.
authors: Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan. suzuma@nagasaki-u.ac.jp
authors: Kiyoshi
authors: K
authors: Suzuma
authors: Yoshihisa
authors: Y
authors: Yamada
authors: Michi
authors: M
authors: Liu
authors: Eiko
authors: E
authors: Tsuiki
authors: Azusa
authors: A
authors: Fujikawa
authors: Takashi
authors: T
authors: Kitaoka
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003930:Diabetic Retinopathy / Q000175:diagnosis*; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D008269:Macular Edema / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D012160:Retina / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000295:instrumentation*; D014792:Visual Acuity / Q000502:physiology