title: Elevated E-selectin and diastolic blood pressure in diabetic children.
abstract: BACKGROUND
  Cardiovascular risk markers are related to micro-angiopathy in children with type 1 diabetes (T1DM), but there is no information about their relationship with blood pressure (BP) and endothelial function.
  
  
  METHODS
  This was a case-control study including 29 children with T1DM (mean age 10·5 ± 2·7 years, disease duration: 3·8 ± 2·2 years) and 39 healthy controls (mean age: 9·8 ± 2·7 years). We assessed 24-h ambulatory BP, vascular function and serum level of lipids, vascular cell adhesion molecule-1 (VCAM-1; ICAM) and selectins (E-selectin; P-selectin).
  
  
  RESULTS
  The subject groups had similar physical characteristics and lipids level, except body mass index (BMI) which was higher in T1DM than in healthy children (18·6 ± 2·6 vs. 16·7 ± 2·5 kg/m(2), P = 0·003). Children with T1DM had increased 24 h diastolic BP z-score (0·62 ± 0·9 vs. -0·65 ± 0·8, P < 0·001), even after adjustment for BMI, as well as higher VCAM-1 concentration (492 ± 346 vs. 340 ± 225 ng/mL, P = 0·039) compared to healthy subjects. Diastolic BP z-scores were associated with disease duration, E-selectin and triglyceride levels in the T1DM group (P < 0·05). E-selectin was also related to triglycerides, otherwise there were no relationships between vascular function, markers and BP.
  
  
  CONCLUSIONS
  E-selectin, an early atherosclerosis biomarker, is positively associated with diastolic BP values in children with T1DM, despite relatively short disease duration.
authors: Paediatric Cardiology Unit, Department of Child and Adolescent, University Hospitals of Geneva, Rue Willy-Donzé, Geneva, Switzerland. albane.maggio@hcuge.ch
authors: Albane B R
authors: AB
authors: Maggio
authors: Nathalie J
authors: NJ
authors: Farpour-Lambert
authors: Fabrizio
authors: F
authors: Montecucco
authors: Graziano
authors: G
authors: Pelli
authors: Laetitia M
authors: LM
authors: Marchand
authors: Valérie
authors: V
authors: Schwitzgebel
authors: François
authors: F
authors: Mach
authors: Yacine
authors: Y
authors: Aggoun
authors: Maurice
authors: M
authors: Beghetti
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology*; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood* / Q000150:complications; D016022:Case-Control Studies; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications; D019040:E-Selectin / Q000097:blood*; D004730:Endothelium, Vascular / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000378:metabolism; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008297:Male; D012307:Risk Factors; D013997:Time Factors; D014280:Triglycerides / Q000097:blood / Q000378:metabolism; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
chemical_list: D015415:Biomarkers; D019040:E-Selectin; D014280:Triglycerides; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1