title: Regulatory T cell: a protection for tumour cells.
abstract: Characterized by immunosuppression regulatory T cells (Tregs) play a key role in maintaining immune tolerance. A growing number of tumours have been found with Tregs accumulating in microenvironment and patients with high density of Tregs in tumour stroma get a worse prognosis, which suggests that Tregs may inhibit anti-tumour immunity in stroma, resulting in a poor prognosis. In this paper, we demonstrate the accumulation of Tregs in tumour stroma and the possible suppressive mechanisms. We also state the immunotherapy that has being used in animal and clinical trials.
authors: The Department of Gastroenterology of Zhongshan Hospital, Fudan University, Shanghai, China.
authors: Yi
authors: Y
authors: Wang
authors: Yushui
authors: Y
authors: Ma
authors: Ying
authors: Y
authors: Fang
authors: Shengdi
authors: S
authors: Wu
authors: Lili
authors: L
authors: Liu
authors: Da
authors: D
authors: Fu
authors: Xizhong
authors: X
authors: Shen
mesh_terms: D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology; D003713:Dendritic Cells / Q000276:immunology / Q000473:pathology; D006801:Humans; D007108:Immune Tolerance; D007167:Immunotherapy; D016753:Interleukin-10 / Q000276:immunology / Q000378:metabolism; D007694:Killer Cells, Natural / Q000276:immunology / Q000473:pathology; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D016212:Transforming Growth Factor beta / Q000276:immunology / Q000378:metabolism; D019139:Tumor Escape; D059016:Tumor Microenvironment / Q000276:immunology
chemical_list: D016212:Transforming Growth Factor beta; D016753:Interleukin-10