title: First description of pseudohypoparathyroidism with frontal lobe calcification and normal serum calcium at the initial manifestation in an otherwise healthy seven-year-old girl.
abstract: Pseudohypoparathyroidism (PHP) is characterized by resistance to the peripheral action of parathyroid hormone. We present a case of a seven-year-old girl who was admitted at the service of Instituto Materno Infantil de Pernambuco, IMIP, with motor episodes affecting the arms. Her calcium level was normal. Computed tomography showed calcifications in frontal lobes and basal ganglia. After six years: calcium was 5.5 mg/dL; phosphorus, 8.3 mg/dL and serum parathyroid hormone was 1,318 pg/mL. Pseudohypoparathyroidism diagnosis was considered. This is the first description of a case of pseudohypoparathyroidism without Albright's stigma, with cerebral calcification, and no calcium abnormalities at the initial clinical manifestation.
authors: Universidade Federal de Pernambuco, Recife, PE, Brazil. anacarlapmontenegro@hotmail.com
authors: Ana Carla
authors: AC
authors: Montenegro
authors: Thais
authors: T
authors: Gelenske
authors: Erico Higino
authors: EH
authors: Carvalho
authors: Francisco
authors: F
authors: Bandeira
authors: Everton
authors: E
authors: Sougey
mesh_terms: D001927:Brain Diseases / Q000175:diagnosis*; D002114:Calcinosis / Q000175:diagnosis* / Q000473:pathology; D002118:Calcium / Q000097:blood*; D002648:Child; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007011:Hypoparathyroidism / Q000175:diagnosis*; D010758:Phosphorus / Q000032:analysis; D011859:Radiography; D012016:Reference Values
chemical_list: D010758:Phosphorus; D002118:Calcium