title: Oral administration of oleic or linoleic acid accelerates the inflammatory phase of wound healing.
abstract: The effects of oral ingestion of oleic (OLA) and linoleic (LNA) acids on wound healing in rats were investigated. LNA increased the influx of inflammatory cells, the concentration of hydrogen peroxide (H(2)O(2)) and cytokine-induced neutrophil chemoattractant-2αβ (CINC-2αβ), and the activation of the transcription factor activator protein-1 (AP-1) in the wound at 1  hour post wounding. LNA decreased the number of inflammatory cells and IL-1, IL-6, and macrophage inflammatory protein-3 (MIP-3) concentrations, as well as NF-κB activation in the wound at 24  hours post wounding. LNA accelerated wound closure over a period of 7 days. OLA increased TNF-α concentration and NF-κB activation at 1  hour post wounding. A reduction of IL-1, IL-6, and MIP-3α concentrations, as well as NF-κB activation, was observed 24  hours post wounding in the OLA group. These data suggest that OLA and LNA accelerate the inflammatory phase of wound healing, but that they achieve this through different mechanisms.
authors: Department of Physiology and Biophysics, Institute of Biomedical Sciences, São Paulo University, São Paulo, Brazil. hosanagr@icb.usp.br
authors: Hosana G
authors: HG
authors: Rodrigues
authors: Marco Aurélio R
authors: MA
authors: Vinolo
authors: Juliana
authors: J
authors: Magdalon
authors: Kaio
authors: K
authors: Vitzel
authors: Renato T
authors: RT
authors: Nachbar
authors: Ana Flávia M
authors: AF
authors: Pessoa
authors: Marinilce F
authors: MF
authors: dos Santos
authors: Elaine
authors: E
authors: Hatanaka
authors: Philip C
authors: PC
authors: Calder
authors: Rui
authors: R
authors: Curi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D054418:Chemokine CCL20 / Q000235:genetics / Q000378:metabolism; D003872:Dermatitis / Q000276:immunology*; D053583:Interleukin-1beta / Q000235:genetics / Q000378:metabolism; D015850:Interleukin-6 / Q000235:genetics / Q000378:metabolism; D019787:Linoleic Acid / Q000494:pharmacology*; D008297:Male; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D019301:Oleic Acid / Q000494:pharmacology*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000276:immunology / Q000293:injuries*; D018808:Transcription Factor AP-1 / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism; D014945:Wound Healing / Q000187:drug effects* / Q000276:immunology*
chemical_list: C486997:Ccl20 protein, rat; D054418:Chemokine CCL20; D053583:Interleukin-1beta; D015850:Interleukin-6; D016328:NF-kappa B; D012333:RNA, Messenger; D018808:Transcription Factor AP-1; D014409:Tumor Necrosis Factor-alpha; D019301:Oleic Acid; D019787:Linoleic Acid