title: Protective effect of soy isoflavone genistein on ischemia-reperfusion in the rat small intestine.
abstract: Ischemia-reperfusion (I/R) injury of the intestine is an important factor associated with high rates of morbidity and mortality. Intestinal I/R is a common clinical problem in the settings of severe burns, circulatory shock and strangulation ileus. Intestinal I/R damages remote organs and promotes multi-organ failure. It has been shown that enteral feeding before ischemic insults is beneficial for reducing organ injury and improving survival after intestinal I/R. In that study, the authors used a standard complex enteral diet and they suggested that it is important to find new nutrient formulas. Since reactive oxygen species are responsible for intestinal I/R injury, we focused on a dietary polyphenol, the soy isoflavone genistein. Genistein has a wide spectrum of biochemical and pharmacological activities. However, the possibility of a protective effect of genistein as enteral nutrition on I/R injury has not been investigated. We therefore investigated the protective effect of genistein on oxidative injury using intestinal I/R model rats. We found that genistein, which has combined antioxidant activity from radical scavenging, xanthine oxidase inhibition and chain-breaking effects, exhibits a protective effect on intestinal I/R injury. The results suggest that genistein, a soy isoflavone, has the possibility as a new nutrient formula of enteral feeding.
authors: Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, Japan.
authors: Yuki
authors: Y
authors: Sato
authors: Shirou
authors: S
authors: Itagaki
authors: Setsu
authors: S
authors: Oikawa
authors: Jiro
authors: J
authors: Ogura
authors: Masaki
authors: M
authors: Kobayashi
authors: Takeshi
authors: T
authors: Hirano
authors: Mitsuru
authors: M
authors: Sugawara
authors: Ken
authors: K
authors: Iseki
mesh_terms: D000818:Animals; D019540:Area Under Curve; D001896:Boron Compounds / Q000037:antagonists & inhibitors / Q000378:metabolism; D016166:Free Radical Scavengers / Q000494:pharmacology*; D019833:Genistein / Q000494:pharmacology*; D007421:Intestine, Small / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D049449:Luminescence; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism; D015427:Reperfusion Injury / Q000378:metabolism / Q000517:prevention & control*
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D016166:Free Radical Scavengers; D017382:Reactive Oxygen Species; D019833:Genistein