title: A new endotoxin adsorber in septic shock: observational case series.
abstract: OBJECTIVE
  Effects of a new endotoxin adsorber on the length of noradrenaline (NA) treatment, LPS (lipopolysaccharide) levels and SOFA (sequential organ failure assessment) scores in septic shock were evaluated.
  
  
  METHODS
  Two-hour hemoperfusion with LPS adsorber was initiated in patients with septic shock and endotoxemia. Controls were matched for age, focus and severity of illness.
  
  
  RESULTS
  Adsorption treatment (n = 9) exhibited a significant decrease in EAA (endotoxin activity assay) activity (0.55 [0.44-0.68] vs. 0.25 [0.13-0.41], p = 0.019) and NA infusion rate (0.217 μg/kg/min [0.119-0.0508] vs. 0 μg/kg/min [0-0.09], p = 0.026) from pretreatment to 24 h post-treatment. The median decrease in SOFA scores from pretreatment to 24 h was 3.0 points (1.5-4.5), p = 0.002. Duration of NA infusion was significantly shorter compared to controls (39 h [31-48] vs. 54 h [43-151], p = 0.03).
  
  
  CONCLUSIONS
  LPS adsorber treatment was associated with a decrease in NA dose, decrease in SOFA scores and LPS concentrations.
authors: Division of Intensive Care Medicine, Department of Anaesthesiology, Oulu University Hospital, Finland. tak @ cc.oulu.fi
authors: T I
authors: TI
authors: Ala-Kokko
authors: J
authors: J
authors: Laurila
authors: J
authors: J
authors: Koskenkari
mesh_terms: D000327:Adsorption; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D019446:Endotoxemia / Q000628:therapy; D004731:Endotoxins / Q000097:blood*; D005260:Female; D006464:Hemoperfusion / Q000379:methods; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D008070:Lipopolysaccharides / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012772:Shock, Septic / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D004731:Endotoxins; D008070:Lipopolysaccharides; D019344:Lactic Acid