title: Plasma fibrinogen levels and restenosis after primary percutaneous coronary intervention.
abstract: Plasma fibrinogen levels influence restenosis following elective percutaneous coronary intervention (PCI) for stable angina. It is unknown whether the same is true in the setting of primary PCI. The aim of the study was therefore to assess whether fibrinogen levels were associated to 6-month in-stent restenosis (ISR) in STEMI patients undergoing successful primary PCI. From January 2003 to October 2004, 267 patients were admitted to our Institution for STEMI and treated by primary PCI. Of these, 171 patients met the inclusion criteria and were enrolled in our study. Fibrinogen levels were assessed at admission, 12 h, 24 h, 48 h, 72 h following PCI and at discharge. Six-month angiographic follow-up was 100% complete. Subjects with 6-month ISR showed higher fibrinogen levels than patients without ISR. Patients in the upper fibrinogen tertile showed a higher 6-month incidence of symptoms and/or inducible myocardial ischemia (27.1% vs. 7.1%, P = 0.006) and a larger late lumen loss (1.3 ± 0.8 vs. 1.0 ± 0.9 mm, P = 0.049). Logistic regression analysis demonstrated a significant and independent association between fibrinogen levels and ISR. Our study suggests that increased plasma fibrinogen levels are related to ISR in STEMI patients undergoing primary PCI. Larger studies are warranted to assess the prognostic value of fibrinogen over harder end-points.
authors: Cardiologia Ospedaliera, Ospedale Maggiore della Carità, Corso Mazzini 18, Novara, Italy. lupialessandro1@tin.it
authors: Alessandro
authors: A
authors: Lupi
authors: Gioel Gabrio
authors: GG
authors: Secco
authors: Andrea
authors: A
authors: Rognoni
authors: Lidia
authors: L
authors: Rossi
authors: Maurizio
authors: M
authors: Lazzero
authors: Federico
authors: F
authors: Nardi
authors: Roberta
authors: R
authors: Rolla
authors: Giorgio
authors: G
authors: Bellomo
authors: Angelo Sante
authors: AS
authors: Bongo
authors: Carlo
authors: C
authors: Di Mario
mesh_terms: D000368:Aged; D060050:Angina, Stable / Q000097:blood* / Q000000981:diagnostic imaging; D006328:Cardiac Catheterization; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000097:blood* / Q000000981:diagnostic imaging; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D005340:Fibrinogen