title: Plasma klotho and cardiovascular disease in adults.
abstract: OBJECTIVE
  To determine whether plasma klotho, a recently discovered hormone that has been implicated in atherosclerosis, is related to prevalent cardiovascular disease (CVD) in adults.
  
  
  METHODS
  Cross-sectional.
  
  
  METHODS
  Population-based sample of adults residing in Tuscany, Italy.
  
  
  METHODS
  One thousand twenty-three men and women aged 24 to 102 participating in the Invecchiare in Chianti (InCHIANTI) study.
  
  
  METHODS
  Anthropometric measures, plasma klotho, fasting plasma total, high-density lipoprotein cholesterol (HDL-C), triglycerides, glucose, creatinine, C-reactive protein (CRP). Clinical measures: medical assessment, diabetes mellitus, hypertension, coronary heart disease, heart failure, stroke, peripheral artery disease, cancer, chronic kidney disease. Logistic regression models were used to examine the relationship between plasma klotho and prevalent CVD.
  
  
  RESULTS
  Of 1,023 participants, 259 (25.3%) had CVD. Median (25th, 75th percentile) plasma klotho concentrations were 676 pg/mL (530, 819 pg/mL). Plasma klotho was correlated with age (correlation coefficient (r) = -0.14, P < .001), HDL-C (r = 0.11, P<.001), and CRP (r = -0.10, P < .001) but not systolic blood pressure, fasting plasma glucose, or renal function. Plasma klotho age-adjusted geometric means were 626 pg/mL (95% confidence interval (CI) = 601-658 pg/mL) in participants with CVD and 671 pg/mL (95% CI = 652-692 pg/mL) in those without CVD (P = .001). Adjusting for traditional cardiovascular risk factors (age, sex, smoking, total cholesterol, HDL-C, systolic blood pressure, and diabetes mellitus), log plasma klotho was associated with prevalent CVD (odds ratio per 1 standard deviation increase = 0.85, 95% CI = 0.72-0.99).
  
  
  CONCLUSIONS
  In community-dwelling adults, higher plasma klotho concentrations are independently associated with a lower likelihood of having CVD.
authors: Department of Ophthalmology, School of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA. rdsemba@jhmi.edu
authors: Richard D
authors: RD
authors: Semba
authors: Anne R
authors: AR
authors: Cappola
authors: Kai
authors: K
authors: Sun
authors: Stefania
authors: S
authors: Bandinelli
authors: Mansi
authors: M
authors: Dalal
authors: Candace
authors: C
authors: Crasto
authors: Jack M
authors: JM
authors: Guralnik
authors: Luigi
authors: L
authors: Ferrucci
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D005260:Female; D005966:Glucuronidase / Q000097:blood*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D000090265:Klotho Proteins; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D055815:Young Adult
chemical_list: D015415:Biomarkers; D005966:Glucuronidase; D000090265:Klotho Proteins