title: [Large cell calcifying Sertoli cell tumor of the testis: a clinicopathological observation].
abstract: OBJECTIVE
  To investigate the clinicopathological characteristics of large cell calcifying Sertoli cell tumor (LCCSCT) of the testis.
  
  
  METHODS
  We studied a case of LCCSCT by light microscopy, Western blotting and immunohistochemistry, reviewed relevant literature, and analyzed the clinical, morphological and immunohistochemical features, treatment and prognosis of the tumor.
  
  
  RESULTS
  The patient was a 25 years old man. Pathohistologically, the tumor was characterized by a mass of polygonal tumor cells in a tubular and trabecular growth pattern, with abundant acidophilic cytoplasm, enlarged vesicular nuclei, and extensive calcified debris in stroma. The tumor cells were positive for inhibin, S-100, vimentin and alcian blue, but negative for PLAP, SMA, CK, AFP and periodic acid-Schiff (PAS) reaction.
  
  
  CONCLUSIONS
  LCCSCT is a rare testicular sex cord stromal tumor. Its diagnosis is based on immunohistochemical staining, and it is to be differentiated from other lesions of the testis, including seminoma, Leydig cell tumor, Sertoli cell node, and androgen insensitivity syndrome. For the treatment of LCCSCT, surgical resection often has a good prognosis.
authors: Department of Pathology, General Hospital of Jinan Military Region, Jinan, Shandong 250031, China. zjfmsf@163.com
authors: Jin-Feng
authors: JF
authors: Zheng
authors: Tong-Da
authors: TD
authors: Cheng
authors: Xiao-Hong
authors: XH
authors: Liu
authors: Hong-Biao
authors: HB
authors: Jing
authors: Ming
authors: M
authors: Geng
authors: Yong-Cheng
authors: YC
authors: Cao
authors: Yi
authors: Y
authors: Liu
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D012707:Sertoli Cell Tumor / Q000473:pathology*; D018312:Sex Cord-Gonadal Stromal Tumors / Q000473:pathology*; D013736:Testicular Neoplasms / Q000473:pathology*; D013737:Testis / Q000473:pathology*