title: Evaluation of a completely automated tissue-sectioning machine for paraffin blocks.
abstract: Tissue-sectioning automation can be a resourceful tool in processing anatomical pathology specimens. The advantages of an automated system compared with traditional manual sectioning are the invariable thickness, uniform orientation and fewer tissue-sectioning artefacts. This short report presents the design of an automated tissue-sectioning device and compares the sectioned specimens with normal manual tissue sectioning performed by an experienced histology technician. The automated system was easy to use, safe and the sectioned material showed acceptable quality with well-preserved morphology and tissue antigenicity. It is expected that the turnaround time will be improved in the near future.
authors: Pathology Information and Communication Technology (PICT) Laboratory, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA. likaono@gmail.com
authors: Maristela L
authors: ML
authors: Onozato
authors: Stephen
authors: S
authors: Hammond
authors: Mark
authors: M
authors: Merren
authors: Yukako
authors: Y
authors: Yagi
mesh_terms: D016477:Artifacts; D057205:Automation, Laboratory; D015415:Biomarkers / Q000032:analysis; D004867:Equipment Design; D006801:Humans; D007150:Immunohistochemistry; D008422:Materials Testing; D008867:Microtomy / Q000295:instrumentation*; D016612:Paraffin Embedding; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012371:Robotics; D016707:Tissue Fixation
chemical_list: D015415:Biomarkers