title: A three-component reaction forming naphthyridones--synthesis of lophocladine analogs.
abstract: A three-component reaction forming dihydro 2,7-naphthyridine-1-ones has been developed. These unstable dihydro intermediates can be either oxidized or reduced to form naphthyridones or tetrahydro naphthyridones, respectively. The reaction tolerates a large variety of aldehydes and amines, and the produced compounds are analogs of the natural product lophocladine A.
authors: Umeå University, Department of Chemistry, SE-90187, Umeå, Sweden.
authors: Magnus
authors: M
authors: Sellstedt
authors: Fredrik
authors: F
authors: Almqvist
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D015394:Molecular Structure; D009287:Naphthyridines / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction
chemical_list: D000447:Aldehydes; D000588:Amines; D009287:Naphthyridines; C510708:lophocladine A