title: [Antibiotics can ameliorate circulatory complications of liver cirrhosis].
abstract: Livercirrhosis can be complicated by a hyperdynamic circulatory syndrome. This is due to translocation of bacteria and bacterial product (bacterial DNA and endotoxins), which stimulate the splanchnic nitric oxide synthase and leads to splanchnic vasodilatation and haemodynamic derangement. This review focuses on how broad spectrum antibiotics can ameliorate the haemodynamic consequences of bacterial translocation. It is possible that the use of broad spectrum antibiotics in the future may be used to prevent other complications of liver cirrhosis than spontaneous bacterial peritonitis and infections after gastrointestinal bleeding.
authors: Medicinsk Gastroenterologisk Afdeling S, Odense Universitetshospital, Sdr. Boulevard 29, 5000 Odense, Denmark. ozomalo@hotmail.com
authors: Bjørn Stæhr
authors: BS
authors: Madsen
authors: Ove B
authors: OB
authors: Schaffalitzky de Muckadell
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D018988:Bacterial Translocation / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006975:Hypertension, Portal / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D019001:Nitric Oxide Synthase / Q000378:metabolism; D013152:Splanchnic Circulation / Q000502:physiology; D013577:Syndrome; D014664:Vasodilation / Q000502:physiology
chemical_list: D000900:Anti-Bacterial Agents; D019001:Nitric Oxide Synthase