title: Neurobiology of bipolar disorder - lessons from migraine disorders.
abstract: Treatment for Bipolar Affective Disorder is at present largely empirical, in the lack of a definitive understanding of the biological basis of the condition. Many theories have been proposed regarding the underlying neurobiology. These have included aetiologies relating to altered neurotrophic factor expression, mitochondrial endoplasmic reticulum dysfunction with related calcium changes, and loss of inhibitory interneurons. Here an attempt is made to integrate such current understanding, in part by considering the changes observed in migraine - a condition which has a number of similarities with bipolar disorder.
authors: University of Cambridge School of Clinical Medicine, UK.
authors: Janathon
authors: J
authors: Holland
authors: Mark
authors: M
authors: Agius
mesh_terms: D000818:Animals; D001714:Bipolar Disorder / Q000235:genetics / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology; D006801:Humans; D008881:Migraine Disorders / Q000235:genetics / Q000503:physiopathology*; D009446:Neurobiology