title: New insights into p53 based therapy.
abstract: A common step in human cancer is the inactivation of the p53 tumor suppressor pathway. This occurs either by mutations in the coding region of the p53 gene itself, or equally commonly, by inactivation of pathways that are required for p53 to exert its cellular function. Dramatic new results from animal models and the widespread availability of p53 activating small molecules are yielding important new insights into the therapeutic and toxic effects of p53 and how these can be exploited for improving therapy of cancer and other diseases.
authors: p53 Laboratory, A*STAR, and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors: David P
authors: DP
authors: Lane
authors: Christopher John
authors: CJ
authors: Brown
authors: Chandra
authors: C
authors: Verma
authors: Chit Fang
authors: CF
authors: Cheok
mesh_terms: D000818:Animals; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
chemical_list: D016159:Tumor Suppressor Protein p53