title: Flavusides A and B, antibacterial cerebrosides from the marine-derived fungus Aspergillus flavus.
abstract: Flavusides A (1) and B (2), two new antibacterial cerebroside derivatives, and the previously described phomaligol A (3), kojic acid (4), methyl kojic acid (5), and dimethyl kojic acid (6) have been isolated from the extract of a marine isolate of the fungus Aspergillus flavus. The structure and absolute stereochemistry of two cerebrosides were assigned on the basis of NMR and Tandem FAB-MS/MS experiments. Compounds 1, 2, and 3 exhibited a mild antibacterial activity against Staphylococcus aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus. The minimum inhibitory concentration (MIC) values for each strain are as follows: compounds 1 and 2 showed 15.6 μg/ml for S. aureus and 31.2 μg/ml for methicillin-resistant S. aureus and multidrug-resistant S. aureus, and compound 3 exhibited 31.2 μg/ml for S. aureus and methicillin-resistant S. aureus and 62.5 μg/ml for multidrug-resistant S. aureus.
authors: Department of Chemistry, Pukyong National University, Busan 608-737, Korea.
authors: Guohua
authors: G
authors: Yang
authors: Louis
authors: L
authors: Sandjo
authors: Keumja
authors: K
authors: Yun
authors: Alain Simplice
authors: AS
authors: Leutou
authors: Gun-Do
authors: GD
authors: Kim
authors: Hong Dae
authors: HD
authors: Choi
authors: Jung Sook
authors: JS
authors: Kang
authors: Jongki
authors: J
authors: Hong
authors: Byeng Wha
authors: BW
authors: Son
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D059001:Aquatic Organisms / Q000382:microbiology; D001231:Aspergillus flavus / Q000737:chemistry*; D002554:Cerebrosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D006028:Glycosphingolipids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D013211:Staphylococcus aureus / Q000187:drug effects; D053719:Tandem Mass Spectrometry
chemical_list: D000900:Anti-Bacterial Agents; D002554:Cerebrosides; D006028:Glycosphingolipids; C568980:flavuside A; C568981:flavuside B