title: Baicalin down-regulates the expression of macrophage migration inhibitory factor (MIF) effectively for rats with ulcerative colitis.
abstract: The purpose of this study was to investigate whether baicalin, a Chinese herbal extract, down-regulates the expression of macrophage migration inhibitory factor (MIF), an inflammatory factor that regulates the function of macrophages (MΦ), in rats with trinitrobenzene sulphonic acid (TNBS)-induced ulcerative colitis (UC). The results showed that baicalin simultaneously down-regulated the expression of MIF, the quantity of MΦs and the amount of MΦ-related cytokines, including macrophage chemotactic factor-1 (MCP-1, CCL2) and macrophage inflammatory protein-3α (MIP-3α, CCL20), in rats with UC. There was no statistical difference between baicailin and mesalazine in down-regulating the expression of MIF. Our study demonstrated that baicalin, an inexpensive but effective monomer, could be a new and alternative pharmaceutical for UC.
authors: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
authors: Shi-Xue
authors: SX
authors: Dai
authors: Ying
authors: Y
authors: Zou
authors: Yan-Ling
authors: YL
authors: Feng
authors: Hong-Bo
authors: HB
authors: Liu
authors: Xue-Bao
authors: XB
authors: Zheng
mesh_terms: D000818:Animals; D018932:Chemokine CCL2 / Q000378:metabolism; D054418:Chemokine CCL20 / Q000378:metabolism; D003093:Colitis, Ulcerative / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D005419:Flavonoids / Q000494:pharmacology*; D007150:Immunohistochemistry; D019746:Intramolecular Oxidoreductases / Q000378:metabolism*; D008263:Macrophage Migration-Inhibitory Factors / Q000378:metabolism*; D008264:Macrophages / Q000187:drug effects*; D019804:Mesalamine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014302:Trinitrobenzenesulfonic Acid / Q000009:adverse effects
chemical_list: C491766:Ccl2 protein, rat; C486997:Ccl20 protein, rat; D018932:Chemokine CCL2; D054418:Chemokine CCL20; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D008263:Macrophage Migration-Inhibitory Factors; C038044:baicalin; D019804:Mesalamine; D014302:Trinitrobenzenesulfonic Acid; D019746:Intramolecular Oxidoreductases; C515599:Mif protein, rat