title: Non-invasive and high-sensitivity scanning detection of magnetic nanoparticles in animals using high-Tc scanning superconducting-quantum-interference-device biosusceptometry.
abstract: Although magnetic nanoparticles (MNPs) have been widely applied to animals in biomedicine, MNPs within animals should be examined in real time, in vivo, and without bio-damaged possibility to evaluate whether the bio-function of MNPs is valid or to further controls the biomedicinal process because of accompanying complex problems such as MNPs distribution and MNPs biodegradation. The non-invasive and high-sensitivity scanning detection of MNPs in animals using ac susceptometry based on a high-T(c) superconducting quantum interference device (SQUID) is presented. The non-invasive results and biopsy results show good agreement, and two gold-standard biomedicine methods, Prussian blue stain and inductively coupled plasma, prove the magnetic results. This confirms that the future clinical diagnosis of bio-functional MNPs could be operated by using scanning SQUID biosusceptometry as conveniently as an ultrasonic probe.
authors: Institute of Electro-Optical Science and Technology, National Taiwan Normal University, Taipei, Taiwan. jjchieh@ntnu.edu.tw
authors: J J
authors: JJ
authors: Chieh
authors: C Y
authors: CY
authors: Hong
mesh_terms: D000818:Animals; D006358:Hot Temperature; D008099:Liver / Q000737:chemistry / Q000166:cytology; D060306:Magnetometry / Q000295:instrumentation*; D059346:Magnets / Q000032:analysis*; D008297:Male; D053758:Nanoparticles / Q000032:analysis*; D051381:Rats