title: No association of polymorphisms in the CDK5, NDEL1, and LIS1 with autism in Chinese Han population.
abstract: Autism is a pervasive neurodevelopmental disorder. CDK5 (cyclin-dependent kinase 5) and its interacting molecules are involved in neurodevelopment. We performed a family-based association analysis between CDK5, NDEL1, and LIS1 polymorphisms and autism in a Chinese Han population. Our study did not detect a significant association. It indicated that common genetic variations in these genes might not play a role in the genetic predisposition to autism.
authors: Key Laboratory for Mental Health, Ministry of Health, Beijing, People's Republic of China.
authors: Lifang
authors: L
authors: Wang
authors: Jun
authors: J
authors: Li
authors: Meixiang
authors: M
authors: Jia
authors: Weihua
authors: W
authors: Yue
authors: Yanyan
authors: Y
authors: Ruan
authors: Tianlan
authors: T
authors: Lu
authors: Jishui
authors: J
authors: Zhang
authors: Jing
authors: J
authors: Liu
authors: Dai
authors: D
authors: Zhang
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000235:genetics*; D000293:Adolescent; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D001321:Autistic Disorder / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology / Q000208:ethnology; D051360:Cyclin-Dependent Kinase 5 / Q000235:genetics*; D005192:Family Health; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008869:Microtubule-Associated Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D002352:Carrier Proteins; D008869:Microtubule-Associated Proteins; C421108:NDEL1 protein, human; D051360:Cyclin-Dependent Kinase 5; C495905:CDK5 protein, human; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; C084102:PAFAH1B1 protein, human