title: Epithelioid solitary fibrous tumor of the central nervous system.
abstract: Epithelioid solitary fibrous tumor (SFT) has recently been reported and is an extremely rare soft-tissue neoplasm. Herein we present an epithelioid SFT attached to the falx cerebri occurring in a Chinese woman. This patient underwent gross-total tumor resection at the age of 30 years and recurred 68 months following the initial total resection. Histologically, the initial lesion exhibited features of classic spindle cell SFT. In contrast, the recurrent tumor demonstrated exclusively epithelioid morphology with significant atypia. Both the original and recurrent lesions showed positivity for vimentin, CD34, Bcl-2, and CD99, whereas were negative for all the remaining antibodies. The epithelioid feature in SFT seems to be associated with a more aggressive clinical behavior in this case and more cases are awaited to verify this possibility. To the best of authors' knowledge, the present case is the first published example of SFT with epithelioid feature in the central nervous system.
authors: Department of Pathology, West China Hospital, Sichuan University, Guo Xue Xiang 37, 610041 Chengdu, Sichuan, China.
authors: Jing
authors: J
authors: Fu
authors: Rui
authors: R
authors: Zhang
authors: Hongying
authors: H
authors: Zhang
authors: Hong
authors: H
authors: Bu
authors: Huijiao
authors: H
authors: Chen
authors: Xiangli
authors: X
authors: Yin
authors: Zhang
authors: Z
authors: Zhang
authors: Bing
authors: B
authors: Wei
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000473:pathology* / Q000601:surgery; D015622:Epithelioid Cells / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D009364:Neoplasm Recurrence, Local; D019635:Neurosurgical Procedures; D054364:Solitary Fibrous Tumors / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor