title: Modulating impact of human chorionic gonadotropin hormone on the maturation and function of hematopoietic cells.
abstract: hCG hormone is a naturally occurring, immune-modulating agent, which is highly expressed during pregnancy and causes improvements of some autoimmune diseases such as multiple sclerosis and Crohn's disease. Little is known about its immune-modulating effects. This study in MNCs of women who received hCG as preconditioning prior to IVF demonstrates that hCG increases anti-inflammatory IL-27 expression and reduces inflammatory IL-17 expression. In addition, we found increased IL-10 levels and elevated numbers of Tregs in peripheral blood of women after hCG application. Rejection of allogeneic skin grafts was delayed in female mice receiving hCG. We conclude that hCG may be useful for the induction of immune tolerance in solid organ transplantation.
authors: Department of Bone Marrow Transplantation, West German Cancer Center, Medical School of University of Duisburg-Essen, University Hospital of Duisburg-Essen, Essen, Germany. michael.koldehoff@uni-duisburg-essen.de
authors: Michael
authors: M
authors: Koldehoff
authors: Thomas
authors: T
authors: Katzorke
authors: Natalie C
authors: NC
authors: Wisbrun
authors: Dirk
authors: D
authors: Propping
authors: Susanne
authors: S
authors: Wohlers
authors: Peter
authors: P
authors: Bielfeld
authors: Nina K
authors: NK
authors: Steckel
authors: Dietrich W
authors: DW
authors: Beelen
authors: Ahmet H
authors: AH
authors: Elmaagacli
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D015536:Down-Regulation / Q000187:drug effects; D005260:Female; D005307:Fertilization in Vitro; D006084:Graft Rejection / Q000517:prevention & control*; D006410:Hematopoiesis / Q000187:drug effects; D006801:Humans; D007108:Immune Tolerance; D056747:Immunomodulation; D016753:Interleukin-10 / Q000096:biosynthesis; D020381:Interleukin-17 / Q000096:biosynthesis; D051379:Mice; D012102:Reproductive Control Agents / Q000494:pharmacology*; D016038:Skin Transplantation / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology*; D014184:Transplantation, Homologous; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D006063:Chorionic Gonadotropin; D020381:Interleukin-17; D012102:Reproductive Control Agents; D016753:Interleukin-10