title: A practical, one-pot synthesis of highly substituted thiophenes and benzo[b]thiophenes from bromoenynes and o-alkynylbromobenzenes.
abstract: An efficient synthesis of thiophenes and benzo[b]thiophenes has been developed from easily available bromoenynes and o-alkynylbromobenzene derivatives. This novel one-pot procedure involves a Pd-catalyzed C-S bond formation using a hydrogen sulfide surrogate followed by a heterocyclization reaction. Moreover, in situ functionalization with selected electrophiles further expands the potential of this methodology to the preparation of the corresponding highly substituted sulfur heterocycles.
authors: Departamento de Química, Área de Química Orgánica, Facultad de Ciencias, Universidad de Burgos, Pza. Misael Bañuelos s/n, 09001-Burgos, Spain.
authors: Verónica
authors: V
authors: Guilarte
authors: Manuel A
authors: MA
authors: Fernández-Rodríguez
authors: Patricia
authors: P
authors: García-García
authors: Elsa
authors: E
authors: Hernando
authors: Roberto
authors: R
authors: Sanz
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D001969:Bromobenzenes / Q000737:chemistry*; D015394:Molecular Structure; D013876:Thiophenes / Q000138:chemical synthesis*
chemical_list: D000475:Alkenes; D000480:Alkynes; D001969:Bromobenzenes; D013876:Thiophenes; C088015:benzothiophene; C032036:bromobenzene