title: Protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis.
abstract: Chikungunya virus (CHIKV) is associated with outbreaks of infectious rheumatic disease in humans. Using a mouse model of CHIKV arthritis and myositis, we show that tumor necrosis factor-α, interferon-γ, and monocyte chemotactic protein 1 (MCP-1) were dramatically induced in tissues from infected mice. The same factors were detected in the serum of patients with CHIKV-induced polyarthralgia and polyarthritis, with MCP-1 levels being particularly elevated. Bindarit (MCP inhibitor) treatment ameliorated CHIKV disease in mice. Histological analysis of muscle and joint tissues showed a reduction in inflammatory infiltrate in infected mice treated with bindarit. These results suggest that bindarit may be useful in treating CHIKV-induced arthritides in humans.
authors: Emerging Viruses and Inflammation Research Group, Institute for Glycomics, Griffith University, Gold Coast, Southport, Australia.
authors: Nestor E
authors: NE
authors: Rulli
authors: Michael S
authors: MS
authors: Rolph
authors: Anon
authors: A
authors: Srikiatkhachorn
authors: Surapee
authors: S
authors: Anantapreecha
authors: Angelo
authors: A
authors: Guglielmotti
authors: Suresh
authors: S
authors: Mahalingam
mesh_terms: D018354:Alphavirus Infections / Q000097:blood / Q000188:drug therapy*; D000818:Animals; D001170:Arthritis, Infectious / Q000473:pathology / Q000517:prevention & control* / Q000821:virology; D018932:Chemokine CCL2 / Q000037:antagonists & inhibitors* / Q000187:drug effects / Q000378:metabolism; D065632:Chikungunya Fever; D002646:Chikungunya virus; D006801:Humans; D007191:Indazoles / Q000494:pharmacology / Q000627:therapeutic use*; D007371:Interferon-gamma / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D023421:Models, Animal; D009220:Myositis / Q000473:pathology / Q000517:prevention & control* / Q000821:virology; D011422:Propionates / Q000494:pharmacology / Q000627:therapeutic use*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D019562:Viral Load / Q000187:drug effects
chemical_list: D018932:Chemokine CCL2; D007191:Indazoles; D011422:Propionates; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma; C079489:bindarit