title: Hormonal mechanisms underlying the relationship between obesity and breast cancer.
abstract: Given the worldwide epidemic of obesity, it is inevitably an increasingly common comorbidity for women who develop breast cancer; therefore, it is critical to understand its impact on this disease. This review focuses on the influence of obesity on breast cancer development and progression and describes the hormonal factors that may underlie the observations, with particular emphasis on the roles of estrogen, insulin/insulin-like growth factor axis, and adipokines.
authors: School of Clinical Sciences, University of Bristol, Southmead Hospital, Bristol, UK. Claire.m.perks@bristol.ac.uk
authors: Claire M
authors: CM
authors: Perks
authors: Jeff M P
authors: JM
authors: Holly
mesh_terms: D054392:Adipokines / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D000818:Animals; D001943:Breast Neoplasms / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D005260:Female; D006801:Humans; D009765:Obesity / Q000150:complications* / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism; D020239:Receptor Cross-Talk / Q000502:physiology; D011960:Receptors, Estrogen / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D012307:Risk Factors; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D013002:Somatomedins / Q000235:genetics / Q000378:metabolism / Q000502:physiology
chemical_list: D054392:Adipokines; D011960:Receptors, Estrogen; D013002:Somatomedins