title: The metabolic syndrome of fructose-fed rats: effects of long-chain polyunsaturated ω3 and ω6 fatty acids. II. Time course of changes in food intake, body weight, plasma glucose and insulin concentrations and insulin resistance.
abstract: The time course for changes in food intake, body weight, plasma glucose             and insulin concentrations and HOMA index was monitored over a period of 8 weeks             in rats exposed from the 8th week after birth to diets containing either starch             or fructose and sunflower oil. In two further groups of rats exposed to the fructose-rich             diet part of the sunflower oil was substituted by either salmon oil rich in long-chain             polyunsaturated ω3 fatty acids or safflower oil rich in long-chain polyunsaturated             ω6 fatty acids. Despite lower food intake, the gain in body weight was higher             in fructose-fed rats than in starch-fed rats. The supplementation of the fructose-rich             diet by either ω3 or ω6 fatty acids lowered both food intake and body weight gain.             The measurements of plasma glucose and insulin concentrations, HOMA index and             insulinogenic index performed after overnight starvation were in fair agreement             with those recorded at the occasion of an intraperitoneal glucose tolerance test,             with higher values for plasma glucose concentration and HOMA index in the fructose-fed             rats exposed to the sunflower oil (with or without enrichment with ω6 fatty acids)             than in the starch-fed rats exposed to the sunflower oil or fructose-fed rats             exposed to a diet enriched with ω3 fatty acids. Such was also the case for the             measurements of glycated albumin at sacrifice. Moreover, the insulinogenic index             was lower in the fructose-fed rats with or without dietary enrichment in ω6 fatty             acids than in the fructose-fed rats with dietary enrichment in ω3 fatty acids.             The elucidation of the biochemical determinants of the later difference requires             further investigations in isolated pancreatic islets.
authors: Department of Biology, Es-Sénia University, Oran, Algeria.
authors: Zoheir
authors: Z
authors: Mellouk
authors: Tarek
authors: T
authors: Hachimi Idrissi
authors: Karim
authors: K
authors: Louchami
authors: Emeline
authors: E
authors: Hupkens
authors: Abdullah
authors: A
authors: Sener
authors: Dalila Ait
authors: DA
authors: Yahia
authors: Willy J
authors: WJ
authors: Malaisse
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000502:physiology*; D001835:Body Weight / Q000502:physiology*; D004435:Eating / Q000502:physiology; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D043371:Fatty Acids, Omega-6 / Q000008:administration & dosage; D005632:Fructose / Q000008:administration & dosage*; D007328:Insulin / Q000097:blood / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology*; D024821:Metabolic Syndrome / Q000097:blood / Q000209:etiology / Q000378:metabolism*; D009928:Organ Specificity; D010938:Plant Oils / Q000008:administration & dosage; D051381:Rats; D000074242:Sunflower Oil
chemical_list: D001786:Blood Glucose; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D007328:Insulin; D010938:Plant Oils; D000074242:Sunflower Oil; D005632:Fructose