title: Investigation of antidepressant medication usage after bariatric surgery.
abstract: BACKGROUND
  Many patients seeking bariatric surgery have a history of mood disorders and are actively prescribed antidepressants. While extensive documentation exists on the impact of weight loss surgery on reductions in cardiac, diabetic, and hypertensive medications, little is known about the impact of bariatric surgery on the use of antidepressant medications.
  
  
  METHODS
  A retrospective study of 439 patients who had undergone Roux-en-Y gastric bypass (RYGB) from January 2001 to November 2004 was examined for postoperative changes in the use of antidepressant medications.
  
  
  RESULTS
  After RYGB, 23% of the patients had an increase in their antidepressant use, 40% continued to require the same antidepressant, 18% had a change in antidepressant medication, and only 16% had a decrease or discontinued their antidepressant.
  
  
  CONCLUSIONS
  Unlike most medications, antidepressant usage did not decrease in the majority of patients after RYGB. These results highlight the prevalence of antidepressant prescription use in patients before and after RYGB and support the need for the careful monitoring of depressive symptoms.
authors: Department of Pharmacy, Mayo Clinic, Rochester, MN, USA. cunningham.julie2@mayo.edu
authors: Julie L
authors: JL
authors: Cunningham
authors: Cory C
authors: CC
authors: Merrell
authors: Michael
authors: M
authors: Sarr
authors: Kristin J
authors: KJ
authors: Somers
authors: Donald
authors: D
authors: McAlpine
authors: Michael
authors: M
authors: Reese
authors: Susanna R
authors: SR
authors: Stevens
authors: Matthew M
authors: MM
authors: Clark
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D015897:Comorbidity; D003863:Depression / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology; D011307:Drug Prescriptions / Q000706:statistics & numerical data*; D005260:Female; D005500:Follow-Up Studies; D015390:Gastric Bypass / Q000523:psychology* / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000150:complications / Q000188:drug therapy*; D009767:Obesity, Morbid / Q000453:epidemiology / Q000523:psychology* / Q000601:surgery; D011184:Postoperative Period; D012189:Retrospective Studies; D014481:United States / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents