title: Impact of clinical status and salivary conditions on xerostomia and oral health-related quality of life of adolescents with type 1 diabetes mellitus.
abstract: OBJECTIVE
  To investigate the influence of clinical status and salivary conditions on the presence of xerostomia on adolescents with and without type 1 diabetes mellitus (DM1), and further to investigate the influence of clinical status, salivary conditions and xerostomia on oral health-related quality of life (OHQoL) of those with DM1.
  
  
  METHODS
  A cross-sectional study was performed on 102 adolescents, 51 with DM1 and 51 nondiabetics. Xerostomia was detected by asking a question about the sensation of having 'dry mouth', and Oral Health Impact Profile-14 was used to measure the impact of xerostomia on OHQoL. The clinical status was assessed by using decayed, missing or filled and Community Periodontal indices, and by evaluating oral manifestations; and the following salivary conditions were evaluated: stimulated salivary flow, pH, buffer capacity, total protein, amylase, urea, calcium, and glucose salivary concentrations. Multiple logistic regression analysis was used to evaluate the influence of clinical status and salivary conditions on xerostomia and the impact of xerostomia on the OHQoL of adolescents with DM1.
  
  
  RESULTS
  Clinical status and salivary conditions was shown to have no influence on the presence of xerostomia. Bivariate (P = 0.00) and logistic regression (P = 0.01) analysis showed a significant association between DM1 and xerostomia. Logistic regression analysis showed association between xerostomia (P = 0.00) and OHQoL, and caries experience (P = 0.03) and OHQoL.
  
  
  CONCLUSIONS
  DM1 showed to be predictive of a high prevalence of xerostomia in adolescents. Caries experience and xerostomia showed to have a negative impact on the OHQoL of adolescents with DM1.
authors: Department of Stomatology, Pontifical Catholic University of Paraná, Curitiba, Brazil. ivanabusato@brturbo.com.br
authors: Ivana Maria Saes
authors: IM
authors: Busato
authors: Sérgio Aparecido
authors: SA
authors: Ignácio
authors: João Armando
authors: JA
authors: Brancher
authors: Simone Tetu
authors: ST
authors: Moysés
authors: Luciana Reis
authors: LR
authors: Azevedo-Alanis
mesh_terms: D000293:Adolescent; D003430:Cross-Sectional Studies; D004245:DMF Index; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000523:psychology; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D009909:Oral Health; D011788:Quality of Life / Q000523:psychology*; D012472:Salivation; D018709:Statistics, Nonparametric; D014987:Xerostomia / Q000150:complications* / Q000523:psychology