title: Neurolymphomatosis in a dog with B-cell lymphoma.
abstract: Lymphoma in the left femoral nerve of a 10-year-old English Cocker Spaniel caused complete paralysis of the affected limb. Neoplastic cells were immunopositive for CD79a and Pax5 and negative for CD3. Neoplastic cells were in multiple lymph nodes and one kidney but spared bone marrow. The clinical and histologic features in this case resemble those of the rare human condition of neurolymphomatosis.
authors: Colorado State University, Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, CO 80523-1644, USA. aluapa@gmail.com
authors: P A
authors: PA
authors: Schaffer
authors: J B
authors: JB
authors: Charles
authors: L
authors: L
authors: Tzipory
authors: J E
authors: JE
authors: Ficociello
authors: S J
authors: SJ
authors: Marvel
authors: J
authors: J
authors: Barrera
authors: T R
authors: TR
authors: Spraker
authors: E J
authors: EJ
authors: Ehrhart
mesh_terms: D000818:Animals; D051925:CD79 Antigens / Q000276:immunology; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D004285:Dogs; D005121:Extremities / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D005263:Femoral Artery / Q000473:pathology; D005267:Femoral Nerve / Q000473:pathology*; D007150:Immunohistochemistry / Q000662:veterinary; D016130:Immunophenotyping / Q000662:veterinary; D007668:Kidney / Q000473:pathology; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D009360:Neoplastic Cells, Circulating / Q000473:pathology; D051757:PAX5 Transcription Factor / Q000276:immunology; D010243:Paralysis; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis / Q000276:immunology / Q000473:pathology / Q000662:veterinary*
chemical_list: D051925:CD79 Antigens; D051757:PAX5 Transcription Factor