title: Low-molecular-weight methylcellulose-based thermo-reversible gel/pluronic micelle combination system for local and sustained docetaxel delivery.
abstract: OBJECTIVE
  To develop low-molecular-weight methylcellulose (LMw MC)-based gel/Pluronic F127 micelle combination system for local and sustained delivery of docetaxel (DTX).
  
  
  METHODS
  LMw MC and Pluronic F127 were used to formulate an injectable thermo-reversible gel/micelle combination system containing DTX. The DTX-loaded combination system was characterized and its therapeutic efficacy evaluated in a subcutaneous tumor model.
  
  
  RESULTS
  Mixtures of LMw MC, AS, and Pluronic F127 formed gel at ~15-40°C depending on AS concentration. The combination system released DTX for >30 days with a biphasic and sustained release pattern, and DTX stability was maintained during release. The combination system significantly enhanced anti-cancer effects of DTX and prolonged survival of the model mouse in comparison with free DTX.
  
  
  CONCLUSIONS
  The LMw MC gel/Pluronic F127 micelle combination system constitutes a promising tool for reducing tumor size and eradicating remaining tumor cells before and after surgery.
authors: Department of Bioengineering, Institute for Bioengineering & Biopharmaceutical Research Hanyang University, 17, Haengdang-dong, Seongdong-gu, Seoul, 133-791, Republic of Korea.
authors: Jang Kyoung
authors: JK
authors: Kim
authors: Young-Wook
authors: YW
authors: Won
authors: Kwang Suk
authors: KS
authors: Lim
authors: Yong-Hee
authors: YH
authors: Kim
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D003692:Delayed-Action Preparations / Q000737:chemistry*; D000077143:Docetaxel; D008297:Male; D008747:Methylcellulose / Q000737:chemistry*; D051379:Mice; D008810:Mice, Inbred C57BL; D008823:Micelles; D009369:Neoplasms / Q000188:drug therapy; D020442:Poloxamer / Q000737:chemistry*; D043823:Taxoids / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D008823:Micelles; D043823:Taxoids; D020442:Poloxamer; D000077143:Docetaxel; D008747:Methylcellulose