title: Preoperative assessment and preparation of patients with diseases affecting the central nervous system.
abstract: OBJECTIVE
  This review will examine the most important issues of preoperative evaluation and preparation in relation to patients with deseases affecting the central nervous system. Those patients may undergo various forms of surgery unrelated to the central nervous system disease. We discuss the effect of physiologic and pharmacological factors on cerebral autoregulation and control of intracranial pressure alongside its clinical relevance with the help of new evidence.
  
  
  RESULTS
  Regardless of the reason for surgery, coexisting diseases of brain often have important implications when selecting anesthetic drugs, procedures and monitoring techniques. Suppression of cerebral metabolic rate is not the sole mechanism for the neuroprotective effect of anaesthetic agents. There are certain general principles, but also some specific circumstances, when we are talking about optimal anesthetic procedure for a patient with coexisting brain disease. Intravenous anesthesia, such as combination of propofol and remifentanil, provides best preservation of autoregulation. Among inhaled agents isoflurane and sevoflurane appear to preserve autoregulation at all doses, whereas with other agents autoregulation is impaired in a dose-related manner. During maintenance of anesthesia the patient is ventilated by intermittent positive pressure ventilation, at intermediate hyperventilation (PaCO2 25-30 mmHg).
  
  
  CONCLUSIONS
  Intraoperative cerebral autoregulation monitoring is an important consideration for the patients with coexisting neurological disease. Transcranial Doppler based static autoregulation measurements appears to be the most robust bedside method for this purpose.
authors: University of Belgrade, School of Medicine, Belgrade, Serbia.
authors: Branko
authors: B
authors: Milaković
authors: Ivan
authors: I
authors: Dimitrijević
authors: Vesna
authors: V
authors: Malenković
authors: Dejan
authors: D
authors: Marković
authors: Vesna
authors: V
authors: Pantić-Palibrk
authors: Ljiljana
authors: L
authors: Gvozdenović
mesh_terms: D000758:Anesthesia / Q000009:adverse effects / Q000379:methods; D001927:Brain Diseases / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D002560:Cerebrovascular Circulation; D006801:Humans; D007427:Intracranial Pressure; D016343:Monitoring, Intraoperative; D011300:Preoperative Care