title: [Lynch syndrome: when pathologist and clinician have the opportunity to reduce the risk of developing cancer].
abstract: Lynch syndrome is an autosomal dominant disease associated with an important risk of cancer, mainly endometrial and colorectal-cancer. This risk can be efficiently lessen by an appropriate screening as far as the mutations carriers are identified. As current clinicopathological recommendations lack sensitivity, a systematic pre-screening of every patient with a colorectal or endometrial cancer can be proposed. Oncogenetic units of the HUG in Geneva and ICHV in Valais have set up a population-based study to evaluate the efficacy of such a strategy. Whatever the approach, the pathologist is directly implicated as Lynch syndrome harbors specific histological aspects that can help to its identification, but also as pre-screening tests are directly realized on tumor-tissue.
authors: Service de pathologie clinique, Département de médecine génétique et de laboratoire, HUG, Genève. Muriel.Genevay@hcuge.ch
authors: M
authors: M
authors: Genevay
authors: P R
authors: PR
authors: Benusiglio
authors: P
authors: P
authors: Hutter
authors: P O
authors: PO
authors: Chappuis
mesh_terms: D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis* / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000517:prevention & control*