title: KIOM-79 inhibits aldose reductase activity and cataractogenesis in Zucker diabetic fatty rats.
abstract: OBJECTIVE
  KIOM-79, a combination of four plant extracts, has a preventive effect on diabetic nephropathy and retinopathy in diabetic animal models. In this study, we have investigated the inhibitory effects of KIOM-79 on diabetic cataractogenesis.
  
  
  METHODS
  We evaluated aldose reductase activity during cataractogenesis using Zucker diabetic fatty (ZDF) rat, an animal model of type 2 diabetes. ZDF rats were treated orally with KIOM-79 (50 mg/kg body weight) once a day for 13 weeks.
  
  
  RESULTS
  In vehicle-treated ZDF rats, lens opacity was increased, and lens fibre swelling and membrane rupture were observed. In addition, aldose reductase activity and aldose reductase protein expression in diabetic lens were markedly enhanced. However, the administration of KIOM-79 inhibited the development of diabetic cataract through the inhibition of aldose reductase activity and protein expression in diabetic lenses.
  
  
  CONCLUSIONS
  These observations suggested that KIOM-79 was useful against the treatment of diabetic cataractogenesis.
authors: Diabetic Complications Research Center, Division of Traditional Korean Medicine Integrated Research, Korea Institute of Oriental Medicine, Daejeon, South Korea.
authors: Junghyun
authors: J
authors: Kim
authors: Chan-Sik
authors: CS
authors: Kim
authors: Eunjin
authors: E
authors: Sohn
authors: Yun Mi
authors: YM
authors: Lee
authors: Jin Sook
authors: JS
authors: Kim
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D002386:Cataract / Q000517:prevention & control*; D003921:Diabetes Mellitus, Experimental / Q000150:complications*; D004487:Edema / Q000517:prevention & control; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D007908:Lens, Crystalline / Q000187:drug effects* / Q000473:pathology; D019684:Magnoliopsida; D008297:Male; D008566:Membranes / Q000187:drug effects / Q000473:pathology; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D011924:Rats, Zucker
chemical_list: D004791:Enzyme Inhibitors; C517978:KIOM 79; D010936:Plant Extracts; D000449:Aldehyde Reductase