title: The chemistry and biology of syringolins, glidobactins and cepafungins (syrbactins).
abstract: Syrbactin is a subordinate term for the syringolin, glidobactin and cepafungin natural product families. Their grouping is based on their related molecular frameworks, similar biosynthesis pathways and, most importantly, identical modes-of-action, being irreversible proteasome inhibition. With this report, we aim to review their chemical biology, describing their common, but also differential characteristics.
authors: Zentrum für Medizinische Biotechnologie, Universität Duisburg-Essen, Germany.
authors: Daniel
authors: D
authors: Krahn
authors: Christian
authors: C
authors: Ottmann
authors: Markus
authors: M
authors: Kaiser
mesh_terms: D001688:Biological Products / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D061988:Proteasome Inhibitors; D014508:Urea / Q000031:analogs & derivatives
chemical_list: D001688:Biological Products; D010456:Peptides, Cyclic; D061988:Proteasome Inhibitors; C407267:syringolin A; C540864:syringolin B; C057878:glidobactin A; D014508:Urea