title: RIG-I-like receptors: cytoplasmic sensors for non-self RNA.
abstract: Viral infection results in the generation of non-self RNA species in the cells, which is recognized by retinoic acid inducible gene-I-like receptors (RLRs), and initiates innate antiviral responses, including the production of proinflammatory cytokines and type I interferon. In this review, we summarize reports on virus-specificity of RLRs, structures of non-self RNA patterns, structural biology of RLRs, and the signaling adapter molecules involved in antiviral innate immunity.
authors: Laboratory of Molecular Genetics, Institute for Virus, Research, Kyoto University, Sakyo-ku, Kyoto, Japan.
authors: Hiroki
authors: H
authors: Kato
authors: Kiyohiro
authors: K
authors: Takahasi
authors: Takashi
authors: T
authors: Fujita
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000276:immunology*; D000818:Animals; D000956:Antigens, Viral / Q000737:chemistry / Q000276:immunology; D003593:Cytoplasm / Q000276:immunology; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D018836:Inflammation Mediators / Q000276:immunology; D007370:Interferon Type I / Q000276:immunology*; D015394:Molecular Structure; D012367:RNA, Viral / Q000737:chemistry / Q000276:immunology; D051192:Receptors, Pattern Recognition / Q000276:immunology*; D018168:Receptors, Retinoic Acid / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology* / Q000821:virology
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000956:Antigens, Viral; D018836:Inflammation Mediators; D007370:Interferon Type I; C437968:PLAAT4 protein, human; D012367:RNA, Viral; D051192:Receptors, Pattern Recognition; D018168:Receptors, Retinoic Acid