title: Efficacy and safety of desmopressin for treatment of nocturia: a systematic review and meta-analysis of double-blinded trials.
abstract: OBJECTIVE
  The purpose of this analysis was to evaluate the efficacy and safety of desmopressin for the treatment of nocturia.
  
  
  METHODS
  Databases including MEDLINE, EMBASE, ISI web of knowledge, the Cochrane Controlled Trial Register of Controlled Trials and Chinese Biological Medical Database were searched to identify randomized controlled trials (RCTs) that referred to the efficacy and safety of desmopressin for the treatment of nocturia. A systematic review and meta-analysis were conducted.
  
  
  RESULTS
  Five studies involving 619 participants were included for the meta-analysis, and 8 RCTs of cross-over design were also identified for the systematic review. The analysis revealed that desmopressin might significantly decrease the frequency of nocturnal voids, nocturnal urine volume and nocturnal diuresis, potentially resulting in an extended duration of the first sleep period and improved sleep quality. The adverse effects of desmopressin were similar to those observed in the placebo group.
  
  
  CONCLUSIONS
  Administered desmopressin was an effective and well-tolerated treatment for nocturia.
authors: Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gong Ti Nan Road (or Beijing Worker Stadium South Road), Chao Yang District, Beijing 100020, China.
authors: Huantao
authors: H
authors: Zong
authors: Chenchen
authors: C
authors: Yang
authors: Xiaoxia
authors: X
authors: Peng
authors: Yong
authors: Y
authors: Zhang
mesh_terms: D050034:Antidiuretic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D053158:Nocturia / Q000188:drug therapy* / Q000503:physiopathology; D016896:Treatment Outcome; D014554:Urination / Q000187:drug effects
chemical_list: D050034:Antidiuretic Agents; D003894:Deamino Arginine Vasopressin