title: Impairment of odor recognition and odor-induced emotions in type 1 myotonic dystrophy.
abstract: This study aimed to test whether type 1 myotonic dystrophy (DM1) patients who have a lower sensitivity to emotional facial expressions have an abnormal olfactory threshold or recognition level. We measured DM1 patients' performances in an olfactory acuity test and respiratory responses to odor stimuli, and compared their results to those of healthy controls (HCs). We found that DM1 patients exhibited a significantly reduced odor detection sensitivity compared with that in HCs. Three out of seven DM1 patients exhibited impaired odor recognition, while other four patients had significantly lower odor recognition compared with HCs. Even when patients were able to identify the type of odor, the levels of pleasantness they reported experiencing in response to a pleasant odor were significantly lower than those reported by HCs. These subjective data in DM1 patients were reflected in the respiratory responses (RRs). In the current study, one patient showed impairments in both odor detection and odor recognition. Abnormalities of the olfactory limbic areas might have been the cause of the olfactory impairments observed in the DM1 patients.
authors: Department of Physiology II, Showa University School of Medicine, Japan.
authors: Yuri
authors: Y
authors: Masaoka
authors: Mitsuru
authors: M
authors: Kawamura
authors: Akitoshi
authors: A
authors: Takeda
authors: Mutsutaka
authors: M
authors: Kobayakawa
authors: Takeshi
authors: T
authors: Kuroda
authors: Hideyo
authors: H
authors: Kasai
authors: Natsuko
authors: N
authors: Tsuruya
authors: Akinori
authors: A
authors: Futamura
authors: Ikuo
authors: I
authors: Homma
mesh_terms: D000328:Adult; D000368:Aged; D000679:Amygdala / Q000502:physiology; D004522:Educational Status; D004644:Emotions / Q000502:physiology*; D018728:Entorhinal Cortex / Q000502:physiology; D005260:Female; D006624:Hippocampus / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009223:Myotonic Dystrophy / Q000523:psychology*; D009483:Neuropsychological Tests; D009812:Odorants; D021641:Recognition, Psychology / Q000502:physiology*; D015656:Respiratory Mechanics / Q000502:physiology; D012684:Sensory Thresholds / Q000502:physiology