title: Enantioselective synthesis of dihydropyridinones via NHC-catalyzed aza-Claisen reaction.
abstract: N-Heterocyclic carbene catalyzed aza-Claisen annulations of enals or their α'-hydroxyenone surrogates with vinylogous amides afford dihydropyridinones. The reaction proceeds with a broad range of substrates, and no nitrogen protecting group is required.
authors: Laboratorium für Organische Chemie, ETH-Zürich, Zürich 8093, Switzerland.
authors: Benedikt
authors: B
authors: Wanner
authors: Jessada
authors: J
authors: Mahatthananchai
authors: Jeffrey W
authors: JW
authors: Bode
mesh_terms: D001372:Aza Compounds / Q000737:chemistry*; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006865:Hydrogenation; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D011728:Pyridones / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D001372:Aza Compounds; D006571:Heterocyclic Compounds; D011728:Pyridones; C030011:carbene; D008697:Methane