title: Diverse metabolic profiles of a Streptomyces strain isolated from a hyper-arid environment.
abstract: The metabolic profile of Streptomyces sp. strain C34, isolated from the Chilean hyper-arid Atacama Desert soil, is dependent on the culture media used for its growth. The application of an OSMAC approach on this strain using a range of cultivation media resulted in the isolation and identification of three new compounds from the rare class of 22-membered macrolactone polyketides, named chaxalactins A-C (1-3). In addition, the known compounds deferroxamine E (4), hygromycin A (5), and 5″-dihydrohygromycin A (6) were detected. The isolated compounds were characterized by NMR spectroscopy and accurate mass spectrometric analysis. Compounds 1-3 displayed strong activity against Gram-positive but weak activity Gram-negative strains tested.
authors: Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Meston Walk, Aberdeen AB24 3UE, Scotland, UK.
authors: Mostafa E
authors: ME
authors: Rateb
authors: Wael E
authors: WE
authors: Houssen
authors: William T A
authors: WT
authors: Harrison
authors: Hai
authors: H
authors: Deng
authors: Chinyere K
authors: CK
authors: Okoro
authors: Juan A
authors: JA
authors: Asenjo
authors: Barbara A
authors: BA
authors: Andrews
authors: Alan T
authors: AT
authors: Bull
authors: Michael
authors: M
authors: Goodfellow
authors: Rainer
authors: R
authors: Ebel
authors: Marcel
authors: M
authors: Jaspars
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D002934:Cinnamates / Q000737:chemistry / Q000302:isolation & purification; D004926:Escherichia coli / Q000187:drug effects; D006921:Hygromycin B / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification; D008089:Listeria monocytogenes / Q000187:drug effects; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D055442:Metabolome; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects; D013302:Streptomyces / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D014733:Vibrio / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D002934:Cinnamates; D018942:Macrolides; C567950:chaxalactin A; C567951:chaxalactin B; C567952:chaxalactin C; D006921:Hygromycin B; C026273:hygromycin A