title: Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
abstract: Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 × 10(-8) to P = 2.3 × 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP.
authors: Department of Health Sciences, University of Leicester, Leicester, UK.
authors: Louise V
authors: LV
authors: Wain
authors: Germaine C
authors: GC
authors: Verwoert
authors: Paul F
authors: PF
authors: O'Reilly
authors: Gang
authors: G
authors: Shi
authors: Toby
authors: T
authors: Johnson
authors: Andrew D
authors: AD
authors: Johnson
authors: Murielle
authors: M
authors: Bochud
authors: Kenneth M
authors: KM
authors: Rice
authors: Peter
authors: P
authors: Henneman
authors: Albert V
authors: AV
authors: Smith
authors: Georg B
authors: GB
authors: Ehret
authors: Najaf
authors: N
authors: Amin
authors: Martin G
authors: MG
authors: Larson
authors: Vincent
authors: V
authors: Mooser
authors: David
authors: D
authors: Hadley
authors: Marcus
authors: M
authors: Dörr
authors: Joshua C
authors: JC
authors: Bis
authors: Thor
authors: T
authors: Aspelund
authors: Tõnu
authors: T
authors: Esko
authors: A Cecile J W
authors: AC
authors: Janssens
authors: Jing Hua
authors: JH
authors: Zhao
authors: Simon
authors: S
authors: Heath
authors: Maris
authors: M
authors: Laan
authors: Jingyuan
authors: J
authors: Fu
authors: Giorgio
authors: G
authors: Pistis
authors: Jian'an
authors: J
authors: Luan
authors: Pankaj
authors: P
authors: Arora
authors: Gavin
authors: G
authors: Lucas
authors: Nicola
authors: N
authors: Pirastu
authors: Irene
authors: I
authors: Pichler
authors: Anne U
authors: AU
authors: Jackson
authors: Rebecca J
authors: RJ
authors: Webster
authors: Feng
authors: F
authors: Zhang
authors: John F
authors: JF
authors: Peden
authors: Helena
authors: H
authors: Schmidt
authors: Toshiko
authors: T
authors: Tanaka
authors: Harry
authors: H
authors: Campbell
authors: Wilmar
authors: W
authors: Igl
authors: Yuri
authors: Y
authors: Milaneschi
authors: Jouke-Jan
authors: JJ
authors: Hottenga
authors: Veronique
authors: V
authors: Vitart
authors: Daniel I
authors: DI
authors: Chasman
authors: Stella
authors: S
authors: Trompet
authors: Jennifer L
authors: JL
authors: Bragg-Gresham
authors: Behrooz Z
authors: BZ
authors: Alizadeh
authors: John C
authors: JC
authors: Chambers
authors: Xiuqing
authors: X
authors: Guo
authors: Terho
authors: T
authors: Lehtimäki
authors: Brigitte
authors: B
authors: Kühnel
authors: Lorna M
authors: LM
authors: Lopez
authors: Ozren
authors: O
authors: Polašek
authors: Mladen
authors: M
authors: Boban
authors: Christopher P
authors: CP
authors: Nelson
authors: Alanna C
authors: AC
authors: Morrison
authors: Vasyl
authors: V
authors: Pihur
authors: Santhi K
authors: SK
authors: Ganesh
authors: Albert
authors: A
authors: Hofman
authors: Suman
authors: S
authors: Kundu
authors: Francesco U S
authors: FU
authors: Mattace-Raso
authors: Fernando
authors: F
authors: Rivadeneira
authors: Eric J G
authors: EJ
authors: Sijbrands
authors: Andre G
authors: AG
authors: Uitterlinden
authors: Shih-Jen
authors: SJ
authors: Hwang
authors: Ramachandran S
authors: RS
authors: Vasan
authors: Thomas J
authors: TJ
authors: Wang
authors: Sven
authors: S
authors: Bergmann
authors: Peter
authors: P
authors: Vollenweider
authors: Gérard
authors: G
authors: Waeber
authors: Jaana
authors: J
authors: Laitinen
authors: Anneli
authors: A
authors: Pouta
authors: Paavo
authors: P
authors: Zitting
authors: Wendy L
authors: WL
authors: McArdle
authors: Heyo K
authors: HK
authors: Kroemer
authors: Uwe
authors: U
authors: Völker
authors: Henry
authors: H
authors: Völzke
authors: Nicole L
authors: NL
authors: Glazer
authors: Kent D
authors: KD
authors: Taylor
authors: Tamara B
authors: TB
authors: Harris
authors: Helene
authors: H
authors: Alavere
authors: Toomas
authors: T
authors: Haller
authors: Aime
authors: A
authors: Keis
authors: Mari-Liis
authors: ML
authors: Tammesoo
authors: Yurii
authors: Y
authors: Aulchenko
authors: Inês
authors: I
authors: Barroso
authors: Kay-Tee
authors: KT
authors: Khaw
authors: Pilar
authors: P
authors: Galan
authors: Serge
authors: S
authors: Hercberg
authors: Mark
authors: M
authors: Lathrop
authors: Susana
authors: S
authors: Eyheramendy
authors: Elin
authors: E
authors: Org
authors: Siim
authors: S
authors: Sõber
authors: Xiaowen
authors: X
authors: Lu
authors: Ilja M
authors: IM
authors: Nolte
authors: Brenda W
authors: BW
authors: Penninx
authors: Tanguy
authors: T
authors: Corre
authors: Corrado
authors: C
authors: Masciullo
authors: Cinzia
authors: C
authors: Sala
authors: Leif
authors: L
authors: Groop
authors: Benjamin F
authors: BF
authors: Voight
authors: Olle
authors: O
authors: Melander
authors: Christopher J
authors: CJ
authors: O'Donnell
authors: Veikko
authors: V
authors: Salomaa
authors: Adamo Pio
authors: AP
authors: d'Adamo
authors: Antonella
authors: A
authors: Fabretto
authors: Flavio
authors: F
authors: Faletra
authors: Sheila
authors: S
authors: Ulivi
authors: Fabiola  M
authors: F
authors: Del Greco
authors: Maurizio
authors: M
authors: Facheris
authors: Francis S
authors: FS
authors: Collins
authors: Richard N
authors: RN
authors: Bergman
authors: John P
authors: JP
authors: Beilby
authors: Joseph
authors: J
authors: Hung
authors: A William
authors: AW
authors: Musk
authors: Massimo
authors: M
authors: Mangino
authors: So-Youn
authors: SY
authors: Shin
authors: Nicole
authors: N
authors: Soranzo
authors: Hugh
authors: H
authors: Watkins
authors: Anuj
authors: A
authors: Goel
authors: Anders
authors: A
authors: Hamsten
authors: Pierre
authors: P
authors: Gider
authors: Marisa
authors: M
authors: Loitfelder
authors: Marion
authors: M
authors: Zeginigg
authors: Dena
authors: D
authors: Hernandez
authors: Samer S
authors: SS
authors: Najjar
authors: Pau
authors: P
authors: Navarro
authors: Sarah H
authors: SH
authors: Wild
authors: Anna Maria
authors: AM
authors: Corsi
authors: Andrew
authors: A
authors: Singleton
authors: Eco J C
authors: EJ
authors: de Geus
authors: Gonneke
authors: G
authors: Willemsen
authors: Alex N
authors: AN
authors: Parker
authors: Lynda M
authors: LM
authors: Rose
authors: Brendan
authors: B
authors: Buckley
authors: David
authors: D
authors: Stott
authors: Marco
authors: M
authors: Orru
authors: Manuela
authors: M
authors: Uda
authors: Melanie M
authors: MM
authors: van der Klauw
authors: Weihua
authors: W
authors: Zhang
authors: Xinzhong
authors: X
authors: Li
authors: James
authors: J
authors: Scott
authors: Yii-Der Ida
authors: YD
authors: Chen
authors: Gregory L
authors: GL
authors: Burke
authors: Mika
authors: M
authors: Kähönen
authors: Jorma
authors: J
authors: Viikari
authors: Angela
authors: A
authors: Döring
authors: Thomas
authors: T
authors: Meitinger
authors: Gail
authors: G
authors: Davies
authors: John M
authors: JM
authors: Starr
authors: Valur
authors: V
authors: Emilsson
authors: Andrew
authors: A
authors: Plump
authors: Jan H
authors: JH
authors: Lindeman
authors: Peter A C 't
authors: PA
authors: Hoen
authors: Inke R
authors: IR
authors: König
authors: Janine F
authors: JF
authors: Felix
authors: Robert
authors: R
authors: Clarke
authors: Jemma C
authors: JC
authors: Hopewell
authors: Halit
authors: H
authors: Ongen
authors: Monique
authors: M
authors: Breteler
authors: Stéphanie
authors: S
authors: Debette
authors: Anita L
authors: AL
authors: Destefano
authors: Myriam
authors: M
authors: Fornage
authors: Gary F
authors: GF
authors: Mitchell
authors: Nicholas L
authors: NL
authors: Smith
authors: Hilma
authors: H
authors: Holm
authors: Kari
authors: K
authors: Stefansson
authors: Gudmar
authors: G
authors: Thorleifsson
authors: Unnur
authors: U
authors: Thorsteinsdottir
authors: Nilesh J
authors: NJ
authors: Samani
authors: Michael
authors: M
authors: Preuss
authors: Igor
authors: I
authors: Rudan
authors: Caroline
authors: C
authors: Hayward
authors: Ian J
authors: IJ
authors: Deary
authors: H-Erich
authors: HE
authors: Wichmann
authors: Olli T
authors: OT
authors: Raitakari
authors: Walter
authors: W
authors: Palmas
authors: Jaspal S
authors: JS
authors: Kooner
authors: Ronald P
authors: RP
authors: Stolk
authors: J Wouter
authors: JW
authors: Jukema
authors: Alan F
authors: AF
authors: Wright
authors: Dorret I
authors: DI
authors: Boomsma
authors: Stefania
authors: S
authors: Bandinelli
authors: Ulf B
authors: UB
authors: Gyllensten
authors: James F
authors: JF
authors: Wilson
authors: Luigi
authors: L
authors: Ferrucci
authors: Reinhold
authors: R
authors: Schmidt
authors: Martin
authors: M
authors: Farrall
authors: Tim D
authors: TD
authors: Spector
authors: Lyle J
authors: LJ
authors: Palmer
authors: Jaakko
authors: J
authors: Tuomilehto
authors: Arne
authors: A
authors: Pfeufer
authors: Paolo
authors: P
authors: Gasparini
authors: David
authors: D
authors: Siscovick
authors: David
authors: D
authors: Altshuler
authors: Ruth J F
authors: RJ
authors: Loos
authors: Daniela
authors: D
authors: Toniolo
authors: Harold
authors: H
authors: Snieder
authors: Christian
authors: C
authors: Gieger
authors: Pierre
authors: P
authors: Meneton
authors: Nicholas J
authors: NJ
authors: Wareham
authors: Ben A
authors: BA
authors: Oostra
authors: Andres
authors: A
authors: Metspalu
authors: Lenore
authors: L
authors: Launer
authors: Rainer
authors: R
authors: Rettig
authors: David P
authors: DP
authors: Strachan
authors: Jacques S
authors: JS
authors: Beckmann
authors: Jacqueline C M
authors: JC
authors: Witteman
authors: Jeanette
authors: J
authors: Erdmann
authors: Ko Willems
authors: KW
authors: van Dijk
authors: Eric
authors: E
authors: Boerwinkle
authors: Michael
authors: M
authors: Boehnke
authors: Paul M
authors: PM
authors: Ridker
authors: Marjo-Riitta
authors: MR
authors: Jarvelin
authors: Aravinda
authors: A
authors: Chakravarti
authors: Goncalo R
authors: GR
authors: Abecasis
authors: Vilmundur
authors: V
authors: Gudnason
authors: Christopher
authors: C
authors: Newton-Cheh
authors: Daniel
authors: D
authors: Levy
authors: Patricia B
authors: PB
authors: Munroe
authors: Bruce M
authors: BM
authors: Psaty
authors: Mark J
authors: MJ
authors: Caulfield
authors: Dabeeru C
authors: DC
authors: Rao
authors: Martin D
authors: MD
authors: Tobin
authors: Paul
authors: P
authors: Elliott
authors: Cornelia M
authors: CM
authors: van Duijn
mesh_terms: D001158:Arteries / Q000378:metabolism; D001794:Blood Pressure / Q000235:genetics*; D016022:Case-Control Studies; D005500:Follow-Up Studies; D056426:Genetic Loci; D055106:Genome-Wide Association Study; D006801:Humans; D006973:Hypertension / Q000235:genetics; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide