title: [Advances in the structure-activity relationship study of natural flavonoids and its derivatives].
abstract: Flavonoids are a large class of compounds widely distributed in nature. Many pharmacological activities of flavonoids have been reported such as anti-cancer, antioxidant, anti-inflammatory, hepatoprotective, antithrombotic, vasodilator, antiviral, antibacterial, antiallergic, and so on. In recent years, domestic and foreign research groups choose natural flavonoids and optimize their chemical structures in order to develop a number of new derivatives with stronger pharmacological activities. As part of the mechanisms are not clear, we need to strengthen in-depth research in the SAR (structure-activity relationship) study for targeted and efficient structure optimization. This paper systematically summarize current researches in the SAR studies of flavonoids and their derivatives, which can serve as a reference for synthesizing new flavonoid derivatives.
authors: College of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors: Jian-Qing
authors: JQ
authors: Zhong
authors: Bo
authors: B
authors: Li
authors: Qi
authors: Q
authors: Jia
authors: Yi-Ming
authors: YM
authors: Li
authors: Wei-Liang
authors: WL
authors: Zhu
authors: Kai-Xian
authors: KX
authors: Chen
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D000985:Antisepsis; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D005343:Fibrinolytic Agents / Q000737:chemistry / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D010946:Plants, Medicinal / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014665:Vasodilator Agents / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D000998:Antiviral Agents; D005343:Fibrinolytic Agents; D005419:Flavonoids; D014665:Vasodilator Agents