title: [Differential diagnosis of thymic hyperplasia and mediastinal tumor in patients with lymphogranulomatosis after chemotherapy].
abstract: OBJECTIVE
  To make differential diagnosis of thymic hyperplasia and mediastinal tumor after chemotherapy (CT) in patients with Hodgkin's disease (HD).
  
  
  METHODS
  The examination of 182 HD patients aged 16-71 years (median 28 years) included chest x-ray computed tomography (XCT) at baseline, during treatment, each 3 months, ultrasound investigation of the chest and abdominal cavity. All the patients received 6-8 courses of the treatment according to the program BEACOPP-14 followed by radiotherapy on the residual tumor in 137 patients, or not followed in 45patients.
  
  
  RESULTS
  Soft tissue tumor in the anterior mediastinum was detected in 14 (31%) from 45 unirradiated patients (age 19-31 years, median 24 years) 1 to 10 months (median 3.5 months) after chemotherapy. The analysis of the data of ultrasound investigation and tomography identified a mediastinal lesion as thymic hyperplasia. The patients are now in remission with follow-up median 21 months (13-36 months). No recurrence was registered.
  
  
  CONCLUSIONS
  Young HD patients with unirradiated mediastinum develop thymic hyperplasia in 31% cases within one year after chemotherapy. In view of this, detection of the lesion in the anterior mediastinum after CT demands complex examination for differential diagnosis of thymic hyperplasia with tumor recurrence to avoid unwanted intensification of the treatment.
authors: T N
authors: TN
authors: Moiseeva
authors: L S
authors: LS
authors: Al'-Radi
authors: I V
authors: IV
authors: Shitareva
authors: A A
authors: AA
authors: Shevelev
authors: I E
authors: IE
authors: Kostina
authors: S K
authors: SK
authors: Kravchenko
authors: A M
authors: AM
authors: Kremenetskaia
authors: N N
authors: NN
authors: Tsyba
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D018572:Disease-Free Survival; D005260:Female; D006689:Hodgkin Disease / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D008875:Middle Aged; D011859:Radiography; D013952:Thymus Hyperplasia / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D014463:Ultrasonography; D055815:Young Adult