title: Minimal impact of excess iodate intake on thyroid hormones and selenium status in older New Zealanders.
abstract: OBJECTIVE
  Iodine deficiency has re-emerged in New Zealand, while selenium status has improved. The aim of this study was to investigate the effects of excess iodine intake as iodate on thyroid and selenium status.
  
  
  METHODS
  In a randomized controlled trial on older people (mean±s.d. 73±4.8 years; n=143), two groups received >50  mg iodine as iodate/day for 8 weeks because of supplement formulation error, either with 100  μg selenium (Se+highI) or without selenium (highI). Four other groups received 80  μg iodine as iodate/day with selenium (Se+lowI) or without selenium (lowI), selenium alone (Se+), or placebo. Thyroid hormones, selenium status, and median urinary iodine concentration (MUIC) were compared at weeks 0, 8, and 4 weeks post-supplementation.
  
  
  RESULTS
  MUIC increased nine- and six-fold in Se+highI and highI groups, decreasing to baseline by week 12. Plasma selenium increased in selenium-supplemented groups (P<0.001). The level of increase in whole blood glutathione peroxidase (WBGPx) in the Se+highI group was smaller than Se+ (P=0.020) and Se+lowI (P=0.007) groups. The decrease in WBGPX in the highI group was greater than other non-selenium-supplemented groups, but differences were not significant. Ten of 43 participants exposed to excess iodate showed elevated TSH (hypothyroidism) at week 8. In all but two, TSH had returned to normal by week 12. In three participants, TSH decreased to <0.10  mIU/l (hyperthyroidism) at week 8, remaining low at week 12.
  
  
  CONCLUSIONS
  Excess iodate induced hypothyroidism in some participants and hyperthyroidism in others. Most abnormalities disappeared after 4 weeks. Excess iodate reduced WBGPx activity and resulted in smaller increases in WBGPx after selenium supplementation.
authors: Department of Human Nutrition, University of Otago, PO Box 56, Dunedin, New Zealand. christine.thomson@otago.ac.nz
authors: Christine D
authors: CD
authors: Thomson
authors: Jennifer M
authors: JM
authors: Campbell
authors: Jody
authors: J
authors: Miller
authors: Sheila A
authors: SA
authors: Skeaff
mesh_terms: D000367:Age Factors; D000368:Aged; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D007452:Iodates / Q000008:administration & dosage*; D007455:Iodine / Q000652:urine*; D008297:Male; D009520:New Zealand / Q000453:epidemiology; D012643:Selenium / Q000097:blood*; D013963:Thyroid Hormones / Q000097:blood*
chemical_list: D007452:Iodates; D013963:Thyroid Hormones; D007455:Iodine; D005979:Glutathione Peroxidase; D012643:Selenium