title: Identification of new CRF51_01B in Singapore using full genome analysis of three HIV type 1 isolates.
abstract: A recent HIV-1 molecular epidemiology survey in Singapore identified a novel CRF01_AE/B recombinant form, which accounted for 13 (11.9%) of 109 patient samples. Peripheral blood mononuclear cell DNA from three of these 13 patients was used to generate near full-length sequences to characterize the novel CRF01_AE/B recombinant form. The three isolates had a recombinant structure composed of CRF01_AE and subtype B, and shared identical breakpoints. As the three patients were not epidemiologically linked, this recombinant form has been designated CRF51_01B. Identification of the novel recombinant forms indicates ongoing active HIV-1 transmission in Singapore.
authors: Johns Hopkins School of Medicine, Johns Hopkins Medical Institution, Baltimore, MD, USA. oong@jhsph.edu
authors: Oon Tek
authors: OT
authors: Ng
authors: Lindsay M
authors: LM
authors: Eyzaguirre
authors: Jean K
authors: JK
authors: Carr
authors: Kuan Kiat
authors: KK
authors: Chew
authors: Li
authors: L
authors: Lin
authors: Arlene
authors: A
authors: Chua
authors: Yee Sin
authors: YS
authors: Leo
authors: Andrew D
authors: AD
authors: Redd
authors: Thomas C
authors: TC
authors: Quinn
authors: Oliver
authors: O
authors: Laeyendecker
mesh_terms: D000328:Adult; D001483:Base Sequence; D005838:Genotype; D006679:HIV Seropositivity / Q000453:epidemiology / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010802:Phylogeny; D012846:Singapore / Q000453:epidemiology