title: Impact of scar, viable myocardium, and epicardial fat on substrate identification of ventricular tachycardia in a case with nonischemic cardiomyopathy.
abstract: A 56-year-old man with nonischemic cardiomyopathy underwent orthotopic cardiac transplantation after endocardial and epicardial radiofrequency catheter ablation for pleomorphic ventricular tachycardia. The myocardial substrate and epicardial fat were comprehensively analyzed with three-dimensional electroanatomic maps, late gadolinium enhanced ex-vivo cardiac magnetic resonance, and histological examination. The association of scar, viable myocardium, and epicardial fat with endocardial and epicardial electrogram voltage and duration was quantitatively defined. This case provides a unique opportunity to explore the reliability of electrical surrogates of scar in nonischemic cardiomyopathy.
authors: Medicine/Cardiology Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. tsasaki1@jhu.edu
authors: Takeshi
authors: T
authors: Sasaki
authors: James
authors: J
authors: Mudd
authors: Charles
authors: C
authors: Steenbergen
authors: Menekhem M
authors: MM
authors: Zviman
authors: Christopher F
authors: CF
authors: Miller
authors: Saman
authors: S
authors: Nazarian
mesh_terms: D000273:Adipose Tissue; D018780:Body Surface Potential Mapping; D009202:Cardiomyopathies / Q000503:physiopathology / Q000601:surgery*; D017115:Catheter Ablation / Q000379:methods*; D002921:Cicatrix / Q000503:physiopathology / Q000601:surgery*; D003287:Contrast Media; D004562:Electrocardiography; D016027:Heart Transplantation; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010496:Pericardium / Q000503:physiopathology / Q000601:surgery*; D017180:Tachycardia, Ventricular / Q000503:physiopathology / Q000601:surgery*
chemical_list: D003287:Contrast Media