title: Associations of HLA-DP variants with hepatitis B virus infection in southern and northern Han Chinese populations: a multicenter case-control study.
abstract: BACKGROUND
  Human leukocyte antigen DP (HLA-DP) locus has been reported to be associated with hepatitis B virus (HBV) infection in populations of Japan and Thailand. We aimed to examine whether the association can be replicated in Han Chinese populations.
  
  
  RESULTS
  Two HLA-DP variants rs2395309 and rs9277535 (the most strongly associated SNPs from each HLA-DP locus) were genotyped in three independent Han cohorts consisting of 2 805 cases and 1 796 controls. By using logistic regression analysis, these two SNPs in the HLA-DPA1 and HLA-DPB1 genes were significantly associated with HBV infection in Han Chinese populations (P = 0.021∼3.36×10(-8) at rs2395309; P = 8.37×10(-3)∼2.68×10(-10) at rs9277535). In addition, the genotype distributions of both sites (rs2395309 and rs9277535) were clearly different between southern and northern Chinese population (P = 8.95×10(-5) at rs2395309; P = 1.64×10(-9) at rs9277535). By using asymptomatic HBV carrier as control group, our study showed that there were no associations of two HLA-DP variants with HBV progression (P = 0.305∼0.822 and 0.163∼0.881 in southern Chinese population, respectively; P = 0.097∼0.697 and 0.198∼0.615 in northern Chinese population, respectively).
  
  
  CONCLUSIONS
  Our results confirmed that two SNPs (rs2395309 and rs9277535) in the HLA-DP loci were strongly associated with HBV infection in southern and northern Han Chinese populations, but not with HBV progression.
authors: Institute of Liver Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
authors: Jin
authors: J
authors: Li
authors: Daguo
authors: D
authors: Yang
authors: Yongwen
authors: Y
authors: He
authors: Mengyi
authors: M
authors: Wang
authors: Zirong
authors: Z
authors: Wen
authors: Lifeng
authors: L
authors: Liu
authors: Jinjian
authors: J
authors: Yao
authors: Koichi
authors: K
authors: Matsuda
authors: Yusuke
authors: Y
authors: Nakamura
authors: Jinling
authors: J
authors: Yu
authors: Xiaorui
authors: X
authors: Jiang
authors: Shuzhen
authors: S
authors: Sun
authors: Qing
authors: Q
authors: Liu
authors: Xiang
authors: X
authors: Jiang
authors: Qilong
authors: Q
authors: Song
authors: Man
authors: M
authors: Chen
authors: Hong
authors: H
authors: Yang
authors: Feng
authors: F
authors: Tang
authors: Xiaowen
authors: X
authors: Hu
authors: Jing
authors: J
authors: Wang
authors: Ying
authors: Y
authors: Chang
authors: Xingxing
authors: X
authors: He
authors: Yuan
authors: Y
authors: Chen
authors: Jusheng
authors: J
authors: Lin
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D006682:HLA-DP Antigens / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006509:Hepatitis B / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
chemical_list: D006682:HLA-DP Antigens