title: Effect of omega-3 fatty acids on serum concentrations of adipokines in healthy cats.
abstract: OBJECTIVE
  To determine associations between serum concentrations of omega-3 polyunsaturated fatty acids and concentrations of adiponectin, leptin, and insulin in healthy cats.
  
  
  METHODS
  56 healthy adult client-owned cats.
  
  
  METHODS
  Body condition score (BCS) was determined, and blood samples were collected after food was withheld for 12 hours. Serum was harvested for fatty acid analysis and measurement of serum concentrations of adiponectin, leptin, insulin, glucose, triglyceride, and cholesterol.
  
  
  RESULTS
  1 cat was removed because of hyperglycemia. Significant interaction effects between BCS and serum concentrations of eicosapentaenoic acid (EPA) were detected for the analyses of associations between EPA and serum concentrations of adiponectin, insulin, and triglyceride. Cats were categorized into nonobese (BCS, 4 to 6 [n = 34 cats]) and obese (BCS, 7 to 8 [21]) groups; serum concentrations of EPA were directly associated with concentrations of adiponectin and inversely associated with concentrations of insulin and triglyceride in obese cats and were directly associated with concentrations of leptin and inversely associated with concentrations of adiponectin in nonobese cats. Additionally, serum concentrations of docosahexaenoic acid were directly associated with concentrations of adiponectin in obese cats. No significant associations between serum concentrations of docosahexaenoic acid or α-linolenic acid were detected in the analyses for all cats. Female cats had higher serum concentrations of adiponectin and lower concentrations of glucose than did male cats. Increased age was associated with a small increase in serum concentrations of leptin.
  
  
  CONCLUSIONS
  EPA may ameliorate the decrease in adiponectin and the increase in insulin and triglyceride concentrations in obese cats.
authors: Department of Pathobiology and Diagnostic Investigation, Diagnostic Center for Population and Animal Health, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA. mazaki-tovi@dcpah.msu.edu
authors: Michal
authors: M
authors: Mazaki-Tovi
authors: Sarah K
authors: SK
authors: Abood
authors: Patricia A
authors: PA
authors: Schenck
mesh_terms: D052242:Adiponectin / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001823:Body Composition; D002371:Cat Diseases / Q000097:blood*; D002415:Cats / Q000097:blood* / Q000502:physiology; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D004281:Docosahexaenoic Acids / Q000097:blood; D015118:Eicosapentaenoic Acid / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D015525:Fatty Acids, Omega-3 / Q000097:blood* / Q000737:chemistry; D005260:Female; D007328:Insulin / Q000097:blood*; D020738:Leptin / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood / Q000662:veterinary*; D012727:Sex Characteristics; D014280:Triglycerides / Q000097:blood; D017962:alpha-Linolenic Acid / Q000097:blood
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D015525:Fatty Acids, Omega-3; D007328:Insulin; D020738:Leptin; D014280:Triglycerides; D017962:alpha-Linolenic Acid; D004281:Docosahexaenoic Acids; D002784:Cholesterol; D015118:Eicosapentaenoic Acid