title: Studies on oxidative stress induced nerve conduction deficits in cigarette smokers.
abstract: An important role of oxidative stress for the development of vascular and neurological complications has encouraged us to undertake a study to assess the oxidative stress induced nerve conduction deficits among cigarette smokers. Eighteen regular male cigarette smokers and twenty nine male non-smokers were diagnosed for clinical neuro-physiological tests viz., motor and sensory nerve conduction velocity (MNCV and SNCV) and redox status. Significant depletion of reduced glutathione (GSH) level (p < 0.05) and significant increase in malondialdehyde (MDA) level (p < 0.01) was found in smokers compared to non-smokers. Motor and sensory nerve conduction velocity showed no significant difference among smokers compared to non-smokers. The present study shows that smoking can induce oxidative stress among smokers but could not exacerbate to nerve conduction deficits.
authors: Analytical Toxicology, Indian Institute of Toxicology Research, Lucknow 226 001, India.
authors: Vipul Kumar
authors: VK
authors: Singh
authors: Manoj Kumar
authors: MK
authors: Pathak
authors: Vipin
authors: V
authors: Bihari
authors: Jyoti
authors: Devendra Kumar
authors: DK
authors: Patel
authors: Neeraj
authors: N
authors: Mathur
authors: C N
authors: CN
authors: Kesavachandran
authors: Mohd Kaleem Javed
authors: MK
authors: Siddiqui
mesh_terms: D000328:Adult; D005260:Female; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009431:Neural Conduction; D018384:Oxidative Stress; D012907:Smoking / Q000378:metabolism / Q000503:physiopathology*; D014026:Nicotiana
chemical_list: D008315:Malondialdehyde; D005978:Glutathione