title: Interkinetic nuclear movement in the ventricular zone of the cortex.
abstract: The nuclei of neuroepithelial cells move along the apicobasal axis in synchronization with their cell cycle status. This motility is known as interkinetic nuclear movement. We discuss here the importance of cytoskeleton organization, the centrosome, molecular motors, cell polarity proteins, and their regulators in controlling and maintaining this typical behavior. Furthermore, due to the tight linkage between cell proliferation, cell cycle, and nuclear motility, we speculate that interkinetic nuclear movement is likely to be affected in the pathophysiology of microcephaly, where the brain size is markedly reduced.
authors: Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel. orly.reiner@weizmann.ac.il
authors: Orly
authors: O
authors: Reiner
authors: Tamar
authors: T
authors: Sapir
authors: Gabi
authors: G
authors: Gerlitz
mesh_terms: D000818:Animals; D002455:Cell Division / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D002467:Cell Nucleus / Q000502:physiology*; D018385:Centrosome / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology*; D006801:Humans; D008831:Microcephaly / Q000473:pathology / Q000503:physiopathology; D020409:Molecular Motor Proteins / Q000235:genetics / Q000502:physiology; D046569:Neuroepithelial Cells / Q000166:cytology* / Q000502:physiology*
chemical_list: D020409:Molecular Motor Proteins