title: Fetal MRI for prediction of neonatal mortality following preterm premature rupture of the fetal membranes.
abstract: BACKGROUND
  Lung MRI volumetrics may be valuable for fetal assessment following early preterm premature rupture of the foetal membranes (pPROM).
  
  
  OBJECTIVE
  To evaluate the predictive value of MRI lung volumetrics after pPROM.
  
  
  METHODS
  Retrospective cohort study of 40 fetuses after pPROM in a large, tertiary, perinatal referral center. Fetuses underwent MRI lung volumetrics. Estimated lung volume was expressed as percentage of expected lung volume (our own normal references). Primary outcome was neonatal mortality due to respiratory distress before discharge from hospital.
  
  
  RESULTS
  Gestational age range was 16-27 weeks. Estimated-to-expected lung volume was 73% in non-survivors and 102% in survivors (P < 0.05). There were no survivors with a lung volume less than 60% of expected. By logistic regression, mortality could be predicted with a sensitivity of 80%, specificity of 86% and accuracy of 85%.
  
  
  CONCLUSIONS
  Fetal MR lung volumetrics may be useful for predicting mortality due to respiratory distress in children with early gestational pPROM.
authors: Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria. agnes.messerschmidt@meduniwien.ac.at
authors: Agnes
authors: A
authors: Messerschmidt
authors: Anna
authors: A
authors: Pataraia
authors: Hanns
authors: H
authors: Helmer
authors: Gregor
authors: G
authors: Kasprian
authors: Alexandra
authors: A
authors: Sauer
authors: Peter C
authors: PC
authors: Brugger
authors: Arnold
authors: A
authors: Pollak
authors: Michael
authors: M
authors: Weber
authors: Daniela
authors: D
authors: Prayer
mesh_terms: D000328:Adult; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000401:mortality* / Q000473:pathology*; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D008168:Lung / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009929:Organ Size; D011237:Predictive Value of Tests; D011247:Pregnancy; D011248:Pregnancy Complications / Q000473:pathology*; D012189:Retrospective Studies