title: Sample collection, biobanking, and analysis.
abstract: Pediatric pharmacokinetic studies require sampling of biofluids from neonates and children. Limitations on sampling frequency and sample volume complicate the design of these studies. In addition, strict guidelines, designed to guarantee patient safety, are in place. This chapter describes the practical implications of sample collection and their storage, with special focus on the selection of the appropriate type of biofluid and withdrawal technique. In addition, we describe appropriate measures for storage of these specimens, for example, in the context of biobanking, and the requirements on drug assay methods that they pose. Pharmacokinetic studies in children are possible, but they require careful selection of an appropriate sampling method, specimen volume, and assay method. The checklist provided could help prospective researchers with the design of an appropriate study protocol and infrastructure.
authors: Department of Clinical Pharmacy, Erasmus MC, Rotterdam, The Netherlands.
authors: Maurice J
authors: MJ
authors: Ahsman
authors: Dick
authors: D
authors: Tibboel
authors: Ron A A
authors: RA
authors: Mathot
authors: Saskia N
authors: SN
authors: de Wildt
mesh_terms: D001771:Blood Banks; D001944:Breath Tests; D005591:Chemical Fractionation / Q000379:methods; D006197:Hair / Q000737:chemistry; D006801:Humans; D007231:Infant, Newborn; D013058:Mass Spectrometry / Q000379:methods; D008470:Meconium / Q000737:chemistry; D010372:Pediatrics / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000032:analysis / Q000097:blood / Q000652:urine; D010599:Pharmacokinetics; D012463:Saliva / Q000737:chemistry; D013048:Specimen Handling / Q000379:methods*
chemical_list: D004364:Pharmaceutical Preparations