title: Humanized mice for studying human leukocyte integrins in vivo.
abstract: Humanized mice have recently emerged as powerful translational animal models for studying human hematopoiesis, immune interactions, and diseases of the human immune system. Several important advances in the humanized mouse technology have been reported over the last few years, thereby resulting in improved engraftment, high levels of human chimerism, and sustained human hematopoiesis. This chapter describes the detailed procedures for generating various humanized mouse models including hu-PBL, hu-HSC, and BLT models and discusses considerations for choosing the appropriate model system.
authors: Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Reservoir Road NW, Washington, DC, USA.
authors: Sang-Soo
authors: SS
authors: Kim
authors: Priti
authors: P
authors: Kumar
authors: Chunting
authors: C
authors: Ye
authors: Premlata
authors: P
authors: Shankar
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006410:Hematopoiesis; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016023:Integrins / Q000235:genetics / Q000378:metabolism*; D007962:Leukocytes / Q000378:metabolism*; D008297:Male; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID
chemical_list: D016023:Integrins