title: Sertraline promotes hippocampus-derived neural stem cells differentiating into neurons but not glia and attenuates LPS-induced cellular damage.
abstract: Sertraline is one of the most commonly used antidepressants in clinic. Although it is well accepted that sertraline exerts its action through inhibition of the reuptake of serotonin at presynaptic site in the brain, its effect on the neural stem cells (NSCs) has not been well elucidated. In this study, we utilized NSCs separated from the hippocampus of fetal rat to investigate the effect of sertraline on the proliferation and differentiation of NSCs. The study demonstrated that sertraline had no effect on NSCs proliferation but it significantly promoted NSCs to differentiate into serotoninergic neurons other than glia cells. Furthermore, we found that sertraline protected NSCs against the lipopolysaccharide-induced cellular damage. These data indicate that sertraline can promote neurogenesis and protect the viability of neural stem cells.
authors: Department of Psychosomatic Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors: Zheng-Wu
authors: ZW
authors: Peng
authors: Yun-Yun
authors: YY
authors: Xue
authors: Hua-Ning
authors: HN
authors: Wang
authors: Huai-Hai
authors: HH
authors: Wang
authors: Fen
authors: F
authors: Xue
authors: Fang
authors: F
authors: Kuang
authors: Bai-Ren
authors: BR
authors: Wang
authors: Yun-Chun
authors: YC
authors: Chen
authors: Li-Yi
authors: LY
authors: Zhang
authors: Qing-Rong
authors: QR
authors: Tan
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D002454:Cell Differentiation / Q000187:drug effects* / Q000502:physiology; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D002478:Cells, Cultured; D005260:Female; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects* / Q000473:pathology; D008070:Lipopolysaccharides / Q000633:toxicity*; D058953:Neural Stem Cells / Q000187:drug effects* / Q000473:pathology; D055495:Neurogenesis / Q000187:drug effects / Q000502:physiology; D009457:Neuroglia / Q000187:drug effects* / Q000473:pathology; D009474:Neurons / Q000187:drug effects* / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D020280:Sertraline / Q000494:pharmacology*
chemical_list: D008070:Lipopolysaccharides; D018696:Neuroprotective Agents; D020280:Sertraline