title: A new biphenyl and antimicrobial activity of extracts and compounds from Clusia burlemarxii.
abstract: Phytochemical investigation on Clusia burlemarxii (Clusiaceae) led to isolation and identification of nine compounds. Were isolated from leaves 3-O-α-L- rhamnopyranosylquercetin, 3-O-α-L-rhamnopyranosylkaempferol, 4-hydroxy-5,5-dimethyldihydrofuran-2-one, 2Z-δ-tocotrienoloic acid and friedelin and were isolated from trunk betulinic acid, protocatechuic acid, lyoniresinol, and a new biphenyl 2,2-dimethyl-3,5-dihydroxy-7-(4-hydroxyphenyl)chromane. The structures were determined by ¹H, ¹³C-NMR, DEPT, HMBC, HMQC, HRESIMS. The Minimal Inhibitory Concentration against Streptococcus mutans, Staphylococcus aureus, Bacillus subtilis, Micrococcus luteus, Escherichia coli, Salmonella choleraesuis, Pseudomonas aeruginosa, Aspergillus niger and Cladosporium cladosporioides was also determined. Extracts and compounds showed significant activity against tested Gram-positive bacteria, none activity against tested Gram-negative bacteria and fungi.
authors: Grupo de Estudos de Substâncias Naturais Orgânicas (GESNAT), Instituto de Química, Universidade Federal da Bahia, Campus Universitário de Ondina, 40170-290, Salvador, Bahia, Brazil.
authors: Paulo R
authors: PR
authors: Ribeiro
authors: Caline G
authors: CG
authors: Ferraz
authors: Maria L S
authors: ML
authors: Guedes
authors: Dirceu
authors: D
authors: Martins
authors: Frederico G
authors: FG
authors: Cruz
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000302:isolation & purification / Q000494:pharmacology*; D031251:Clusia / Q000737:chemistry*; D005658:Fungi / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves; D018547:Plant Stems
chemical_list: C571581:2,2-dimethyl-3,5-dihydroxy-7-(4-hydroxyphenyl)chromane; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001713:Biphenyl Compounds; D010936:Plant Extracts