title: Chemoresistance of Plasmodium falciparum and Plasmodium vivax parasites in Brazil: consequences on disease morbidity and control.
abstract: In Brazil, malaria still remains a clinically important febrile syndrome for local populations and travelers, occurring mostly in the Amazon Basin. This review aims to report the main efforts employed to control this disease since the 1940s and the emergence of Plasmodium falciparum and Plasmodium vivax chemoresistance to chloroquine and sulphadoxine-pyrimethamine among other drugs. Additionally, in vivo, in vitro and molecular studies as well as malaria chemoresistance consequences on disease morbidity and policy treatment guidelines were commented.
authors: Centro de Pesquisa em Malária, Centro de Pesquisa, Diagnóstico e Treinamento em Malária, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, Brasil.
authors: Bianca Ervatti
authors: BE
authors: Gama
authors: Marcus Vinicius Guimarães
authors: MV
authors: Lacerda
authors: Cláudio Tadeu
authors: CT
authors: Daniel-Ribeiro
authors: Maria de Fátima
authors: Mde F
authors: Ferreira-da-Cruz
mesh_terms: D000962:Antimalarials / Q000494:pharmacology* / Q000627:therapeutic use; D001938:Brazil; D004351:Drug Resistance; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000469:parasitology / Q000517:prevention & control*; D016780:Malaria, Vivax / Q000188:drug therapy / Q000469:parasitology / Q000517:prevention & control*; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000235:genetics; D010966:Plasmodium vivax / Q000187:drug effects* / Q000235:genetics
chemical_list: D000962:Antimalarials