title: Infrared multiphoton dissociation tandem charge detection-mass spectrometry of single megadalton electrosprayed ions.
abstract: This work presents the implementation of tandem mass spectrometry for experiments on single electrosprayed ions from compounds of megadalton (MDa) molecular weight, using two charge detection devices. The first mass spectrometry stage (first charge detection device) combined with an ion gate allows both mass-to-charge ratio and charge selections of the megadalton ion of interest. The second stage is based on an electrostatic ion trap and consists of an image charge detection tube mounted between two ion mirrors. Single MDa ions can be stored for several dozen milliseconds. During the trapping time, single ions can be irradiated by a continuous wavelength CO(2) laser. We observe stepwise changes in the charge of a single trapped ion owing to multiphoton activation. Illustration of infrared multiphoton dissociation tandem mass spectrometry are given for single megadalton ions of poly(ethylene oxide)s and DNAs.
authors: Université de Lyon, Lyon, France.
authors: Tristan
authors: T
authors: Doussineau
authors: Cong Yu
authors: CY
authors: Bao
authors: Christian
authors: C
authors: Clavier
authors: Xavier
authors: X
authors: Dagany
authors: Michel
authors: M
authors: Kerleroux
authors: Rodolphe
authors: R
authors: Antoine
authors: Philippe
authors: P
authors: Dugourd