title: Randomized in situ clinical study comparing the ability of two new desensitizing toothpaste technologies to occlude patent dentin tubules.
abstract: OBJECTIVE
  To compare the ability of two new desensitizing toothpaste technologies (one a 5% NovaMin-based toothpaste and the other an 8% arginine-based toothpaste) to occlude patent dentin tubules in a clinical environment relative to a negative control of water and a control toothpaste after four days of twice-daily brushing and dietary acidic challenges.
  
  
  METHODS
  The study design was a single-center, single-blind, randomized, split-mouth, four-treatment, two-period, crossover, in situ clinical study. Healthy subjects wore two lower intra-oral appliances, retaining four dentin samples for four treatment days for each period of the clinical study. Samples were brushed twice daily with a test product (days 1-4), with an additional acidic challenge introduced on two selective days. Scanning electron microscopy (SEM) images were taken of the dentin surface, and dentinal tubule occlusion assessed using a categorical scale.
  
  
  RESULTS
  The results demonstrated that the 5% NovaMin toothpaste was statistically superior at occluding patent dentin tubules compared to water (p = 0.009) and the control toothpaste (p = 0.02) at day 4. In contrast, the treatment effect resulting from the 8% arginine toothpaste did not demonstrate the same degree of occlusive propensity, showing no significant difference to the water and control toothpaste at the day 4 time point.
  
  
  CONCLUSIONS
  Application of the 5% NovaMin toothpaste to dentin showed better dentin tubule occlusion and retention abilities in an oral environment under dietary acid challenge conditions, more so than the 8% arginine toothpaste technology. Given modern dietary habits and practices, these results highlight differences in the acid resistance properties of occlusion technologies, and a potential impact on clinical performance.
authors: Clinical Trials Unit, School of Oral and Dental Sciences University of Bristol, Bristol, UK. N.X.West@bristol.ac.uk
authors: N X
authors: NX
authors: West
authors: E L
authors: EL
authors: Macdonald
authors: S B
authors: SB
authors: Jones
authors: N C A
authors: NC
authors: Claydon
authors: N
authors: N
authors: Hughes
authors: P
authors: P
authors: Jeffery
mesh_terms: D000143:Acids; D000328:Adult; D001120:Arginine / Q000627:therapeutic use*; D001628:Beverages; D002119:Calcium Carbonate / Q000627:therapeutic use*; D032083:Citrus paradisi; D018592:Cross-Over Studies; D003804:Dentin / Q000187:drug effects* / Q000648:ultrastructure; D057133:Dentin Desensitizing Agents / Q000627:therapeutic use*; D005260:Female; D005459:Fluorides / Q000627:therapeutic use*; D005898:Glass; D006801:Humans; D008297:Male; D008855:Microscopy, Electron, Scanning; D010710:Phosphates / Q000627:therapeutic use*; D016037:Single-Blind Method; D013997:Time Factors; D014100:Toothpastes / Q000627:therapeutic use*; D014867:Water / Q000737:chemistry
chemical_list: D000143:Acids; D057133:Dentin Desensitizing Agents; C510984:NovaMin; D010710:Phosphates; D014100:Toothpastes; D014867:Water; C012980:fluorophosphate; D001120:Arginine; D002119:Calcium Carbonate; D005459:Fluorides