title: Multiple adaptive substitutions during evolution in novel environments.
abstract: We consider an asexual population under strong selection-weak mutation conditions evolving on rugged fitness landscapes with many local fitness peaks. Unlike the previous studies in which the initial fitness of the population is assumed to be high, here we start the adaptation process with a low fitness corresponding to a population in a stressful novel environment. For generic fitness distributions, using an analytic argument we find that the average number of steps to a local optimum varies logarithmically with the genotype sequence length and increases as the correlations among genotypic fitnesses increase. When the fitnesses are exponentially or uniformly distributed, using an evolution equation for the distribution of population fitness, we analytically calculate the fitness distribution of fixed beneficial mutations and the walk length distribution.
authors: Theoretical Sciences Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India. jain@jncasr.ac.in
authors: Kavita
authors: K
authors: Jain
authors: Sarada
authors: S
authors: Seetharaman
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics*; D004777:Environment; D019143:Evolution, Molecular; D056084:Genetic Fitness / Q000235:genetics; D008957:Models, Genetic; D009154:Mutation; D012641:Selection, Genetic