title: Inhibition of mitochondrial respiratory chain is involved in triptolide-induced liver injury.
abstract: Triptolide, a diterpenoid epoxide, is one of the major active ingredients of Tripterygium wilfordii Hook F, a woody vine plant called lei gong teng in China, which is used in traditional Chinese Medicine (TCM) for treating many diseases. In this paper, we investigate the relation between inhibition of mitochondrial respiratory chain and liver injury induced by triptolide. Results indicate that the secondary β-oxidation impairment caused by inhibition of mitochondrial respiratory chain is involved in triptolide-induced liver injury, which featured by microvesicular steatosis, hyperlactacidemia and enhanced oxidant stress, although other mechanisms of triptolide-induced liver injury may also exist.
authors: Jiangsu Center for Drug Screening, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.
authors: Qiang
authors: Q
authors: Fu
authors: Xiao
authors: X
authors: Huang
authors: Bin
authors: B
authors: Shu
authors: Mei
authors: M
authors: Xue
authors: Pinghu
authors: P
authors: Zhang
authors: Tao
authors: T
authors: Wang
authors: Li
authors: L
authors: Liu
authors: Zhenzhou
authors: Z
authors: Jiang
authors: Luyong
authors: L
authors: Zhang
mesh_terms: D000818:Animals; D019069:Cell Respiration / Q000187:drug effects*; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000378:metabolism*; D004224:Diterpenes / Q000009:adverse effects*; D004852:Epoxy Compounds / Q000009:adverse effects; D005234:Fatty Liver / Q000139:chemically induced; D005260:Female; D019344:Lactic Acid / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D051336:Mitochondrial Membranes / Q000187:drug effects* / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects; D010616:Phenanthrenes / Q000009:adverse effects*; D010936:Plant Extracts / Q000009:adverse effects* / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D029757:Tripterygium / Q000009:adverse effects* / Q000737:chemistry
chemical_list: D004224:Diterpenes; D004852:Epoxy Compounds; D010616:Phenanthrenes; D010936:Plant Extracts; C041579:lei gong teng; C001899:triptolide; D019344:Lactic Acid