title: Methylenetetrahydrofolate reductase gene polymorphisms in children with attention deficit hyperactivity disorder.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the relationship between 5,10- methylenetetrahydrofolate reductase (MTHFR) polymorphisms and Attention Deficit Hyperactivity Disorder (ADHD) in a sample of Turkish children.
  
  
  METHODS
  MTHFR gene polymorphisms were assessed in 40 patients with ADHD and 30 healty controls. Two mutations in the MTHFR gene were investigated using polymerase chain reactions and restriction fragment length polymorphisms.
  
  
  RESULTS
  Although there were no statistically significant differences in genotype distributions of the C677T alleles between the ADHD and the control groups (p=0,678) but the genotypic pattern of the distributions of the A1298C alleles was different between the ADHD patients and the controls (p=0,033).
  
  
  CONCLUSIONS
  Preliminary data imply a possible relationship between A1298C MTHFR polymorphisms and the ADHD.
authors: Department of Child and Adolescent Psychiatry, Medicine Faculty of Gaziantep University, Gaziantep, Turkey. cemgokcen@gantep.edu.tr
authors: Cem
authors: C
authors: Gokcen
authors: Nadir
authors: N
authors: Kocak
authors: Ahmet
authors: A
authors: Pekgor
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000453:epidemiology / Q000235:genetics*; D002648:Child; D005260:Female; D005492:Folic Acid / Q000097:blood; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007175:Impulsive Behavior / Q000235:genetics; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D018401:Sample Size; D014421:Turkey / Q000453:epidemiology
chemical_list: D005492:Folic Acid; D042965:Methylenetetrahydrofolate Reductase (NADPH2)