title: Prooxidant-anti-oxidant balance is not associated with extent of coronary artery disease.
abstract: OBJECTIVE
  We have measured the pro-oxidant-antioxidant-balance (PAB) levels in patients with defined coronary artery disease (CAD) and compared them with concentrations in healthy subjects.
  
  
  METHODS
  Based on angiography results, 400 patients with stable CAD were divided into CAD- and CAD+, this being further subcategorized into groups with single-, double- and triple-vessel disease (VD).
  
  
  RESULTS
  The mean PAB values in the healthy subjects, was significantly lower than for other groups (P<0.001). In CAD- patients, PAB levels were 123.2 ± 43.9, which was not statistically different compared to groups with SVD, 2VD and 3VD (P>0.05). In the CAD+ group, PAB values in 1VD, 2VD and 3VD were not significantly different among patients with SVD, 2VD and 3VD (P>0.05).
  
  
  CONCLUSIONS
  In conclusion, we found higher levels of oxidative stress in CAD+ patients compared to healthy subjects. The oxidation level was not related to measures of the extent of CAD such as number of stenosed vessels.
authors: Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
authors: Amir Ali
authors: AA
authors: Rahsepar
authors: Hossein
authors: H
authors: Pourghadamyari
authors: Mohsen
authors: M
authors: Moohebati
authors: Seyyed Mohammad Reza
authors: SM
authors: Parizadeh
authors: Shima
authors: S
authors: Tavallaie
authors: Roghayeh
authors: R
authors: Paydar
authors: Homa
authors: H
authors: Falsoleiman
authors: Mashalla
authors: M
authors: Dehghani
authors: Afsoon
authors: A
authors: Fazlinezhad
authors: Maral
authors: M
authors: Amini
authors: Fatemeh
authors: F
authors: Khorashadizadeh
authors: Majid
authors: M
authors: Ghayour-Mobarhan
authors: Gordon A
authors: GA
authors: Ferns
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000097:blood*
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species