title: Factors associated with oxidative stress in women with breast cancer.
abstract: OBJECTIVE
  To assess the association between physiological, physical, lifestyle and nutritional variables and oxidative stress biomarkers in women with breast cancer.
  
  
  METHODS
  This cross-sectional study was conducted on 55 women newly diagnosed with breast cancer. The extent of oxidative stress was analyzed by the measurement of plasma lipid hydroperoxides (LH), thiobarbituric acid reactive substances (TBARS), protein carbonyl, whole blood reduced glutathione (GSH) and serum antioxidant capacity (AC). Diet data were obtained from food frequency questionnaire. Linear regression was used to determine the association between the variables studied and oxidative stress biomarkers. The protein carbonyl data was not included in the linear regression analyses since the data did not show a normal distribution, even after logarithmic and other transformations.
  
  
  RESULTS
  After adjusting for energy intake, the intake of chicken and high-fat dairy products was associated with increased levels of LH, while vitamin E intake was associated with decreased LH levels (R² = 23.8%). Intake of oils was associated with increased levels of TBARS (R² = 6.82%). Positive axillary lymph node status was associated with decreased levels of GSH (R² = 9.31%). Increasing age was directly associated with levels of AC, while animal fat, dairy product, and sweet food intakes were associated with low levels of AC (R² = 41.42%).
  
  
  CONCLUSIONS
  Intake of chicken, vitamin E, dairy products (particularly high-fat dairy products), oils, animal fat, and sweet foods, along with axillary lymph node status and age, may be important determinants of oxidative stress in women with breast cancer.
authors: Post-Graduate Program in Nutrition, Santa Catarina Federal Universiy, Florianopolis, SC, Brazil.
authors: F G K
authors: FG
authors: Vieira
authors: P F
authors: PF
authors: Di Pietro
authors: B C B
authors: BC
authors: Boaventura
authors: C
authors: C
authors: Ambrosi
authors: G
authors: G
authors: Rockenbach
authors: Ma A
authors: MA
authors: Fausto
authors: C G
authors: CG
authors: Crippa
authors: E L
authors: EL
authors: Da Silva
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers; D001943:Breast Neoplasms / Q000378:metabolism*; D003430:Cross-Sectional Studies; D004032:Diet; D005260:Female; D006801:Humans; D007202:Indicators and Reagents; D008019:Life Style; D016014:Linear Models; D015227:Lipid Peroxidation / Q000502:physiology; D008054:Lipid Peroxides / Q000378:metabolism; D008875:Middle Aged; D009043:Motor Activity; D009752:Nutritional Status; D018384:Oxidative Stress / Q000502:physiology*; D050050:Protein Carbonylation
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D007202:Indicators and Reagents; D008054:Lipid Peroxides