title: Diffuse periventricular leukomalacia in preterm children: assessment of grey matter changes by MRI.
abstract: BACKGROUND
  Preterm children may have cognitive deficits and behavioural disorders suggestive of grey matter (GM) injury. The prevalence is higher in preterm children with diffuse periventricular leukomalacia (dPVL).
  
  
  OBJECTIVE
  Evaluate changes in the volume of 116 GM areas in preterm children with dPVL.
  
  
  METHODS
  Eleven preterm children with dPVL, gestational age 32.8 ± 2.6 weeks, examined at corrected age 22.0 ± 18.2 months and 33 matched preterm controls with normal brain MRI were studied. Volumes of 116 individual GM areas, and white matter/cerebrospinal fluid (WM/CSF) ratio were calculated on T1-weighted high-resolution images after segmentation.
  
  
  RESULTS
  Relative to controls, children with dPVL had decreased GM volume of the hippocampus, amygdala, and frontal lobes and temporal middle gyrus (P < 0.05); increased GM volume of the putamen, thalamus, globus pallidum, superior temporal gyrus and of the parietal and occipital lobes (P < 0.05) and lower WM volume/higher CSF volume (P < 0.05). WM/CSF ratios also differed (P < 0.05).
  
  
  CONCLUSIONS
  Preterm children with dPVL have increased regional GM volume in some areas probably related with a process of brain plasticity-regeneration and reduced GM volume in areas associated with cognition and memory.
authors: Department of Radiology, Medical School, University of Ioannina, 45110 Ioannina, Greece.
authors: L C
authors: LC
authors: Tzarouchi
authors: V
authors: V
authors: Xydis
authors: A K
authors: AK
authors: Zikou
authors: A
authors: A
authors: Drougia
authors: L G
authors: LG
authors: Astrakas
authors: M
authors: M
authors: Papastefanaki
authors: S
authors: S
authors: Andronikou
authors: Maria I
authors: MI
authors: Argyropoulou
mesh_terms: D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007969:Leukomalacia, Periventricular / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009474:Neurons / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity