title: Ionic liquid mediated Cu-catalyzed cascade oxa-Michael-oxidation: efficient synthesis of flavones under mild reaction conditions.
abstract: Flavonoids are a class of natural products, found in a wide range of vascular plants and dietary components. Their low toxicity and extensive biological activities, including anti-cancer and anti-bacterial, have made them attractive candidates to serve as therapeutic agents for many diseases. Herein, we disclose a highly efficient synthetic method of CuI-catalyzed cascade oxa-Michael-oxidation, using chalcones as substrates, mediated by the ionic liquid [bmim][NTf2] at a low temperature. This efficient synthetic method has demonstrated high synthetic utility and can afford flavones in good to high yields (up to 98%).
authors: Faculty of Engineering and Light Industry, Guang Dong University of Technology, Guang Dong, 510006, China.
authors: Zhiyun
authors: Z
authors: Du
authors: Huifen
authors: H
authors: Ng
authors: Kun
authors: K
authors: Zhang
authors: Huaqiang
authors: H
authors: Zeng
authors: Jian
authors: J
authors: Wang
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D047309:Flavones / Q000138:chemical synthesis*; D007454:Iodides / Q000737:chemistry*; D052578:Ionic Liquids / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D047309:Flavones; D007454:Iodides; D052578:Ionic Liquids; D003300:Copper; C073870:cuprous iodide