title: A double-blind evaluation of alprazolam and imipramine in the treatment of major depression.
abstract: This report describes the results of a multicentre collaborative study comparing the safety and efficacy of alprazolam with imipramine in patients suffering from major depressive disorder. Two hundred and eight patients diagnosed as major depression as per DSM-III criteria were randomly allocated to alprazolam (N= 105) or imipramine (N = 103) in a double-blind fashion. Detailed assessments were carried out for a period of six weeks. Results revealed that alprazolam was as effective as imipramine as an antidepressant. Side effects were less frequently reported with alprazolam.
authors: Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bangalore 560029.
authors: R S
authors: RS
authors: Murthy
authors: S
authors: S
authors: Chatterjee
authors: T G
authors: TG
authors: Sriram
authors: L P
authors: LP
authors: Shah
authors: R
authors: R
authors: Parikh
authors: S
authors: S
authors: Elavia
authors: G C
authors: GC
authors: Munjal
authors: R
authors: R
authors: Nehru
authors: V
authors: V
authors: Ramachandran
authors: G
authors: G
authors: Nirmala
authors: K S
authors: KS
authors: Raghavan
authors: V
authors: V
authors: Kumar