title: Antiproliferative activity of some 1,4-dimethylcarbazoles on cells that express estrogen receptors: part I.
abstract: Several 9H-carbazole derivatives are used for various pharmacological applications. Many of these compounds demonstrated cytotoxic and anticancer activities. In this work, we have investigated the cytotoxic activity of some substituted carbazoles against cancer cell lines (MCF-7, and ISK). The derivative 2a showed the highest inhibitory activity against both cell lines.
authors: Department of Pharmaceutical Sciences, University of Calabria, Arcavacata di Rende (CS), Italy.
authors: Anna
authors: A
authors: Caruso
authors: Adele
authors: A
authors: Chimento
authors: Hussein
authors: H
authors: El-Kashef
authors: Jean-Charles
authors: JC
authors: Lancelot
authors: Antonella
authors: A
authors: Panno
authors: Vincenzo
authors: V
authors: Pezzi
authors: Carmela
authors: C
authors: Saturnino
authors: Maria Stefania
authors: MS
authors: Sinicropi
authors: Rosa
authors: R
authors: Sirianni
authors: Sylvain
authors: S
authors: Rault
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D002227:Carbazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D018269:Carcinoma, Endometrioid / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D016889:Endometrial Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D015394:Molecular Structure; D011960:Receptors, Estrogen / Q000378:metabolism*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D002227:Carbazoles; D011960:Receptors, Estrogen