title: Expression patterns of the tumor suppressor PDCD4 and correlation with             β-catenin expression in gastric cancers.
abstract: The expression patterns of PDCD4, a tumor suppressor, and β-catenin were             immunohistologically investigated in gastric carcinoma tissues. In normal gastric             tissues, PDCD4 was strongly expressed in the cell nuclei, but weakly expressed             in the cytoplasm. In gastric adenocarcinoma tissues, nuclear PDCD4 expression             was decreased, while cytoplasmic PDCD4 expression was unchanged or somewhat increased.             In gastric signet ring cell carcinoma tissues, PDCD4 expression patterns were             different from the expression patterns of the adenocarcinoma tissues, and PDCD4             was localized in the nuclei of the carcinoma cells as a belt in the middle of             the epithelial layer. The nuclear localization of PDCD4 in the adenocarcinoma             tissues was correlated with the membrane localization of β-catenin, the activation             of which stimulates invasion of colon cancer cells. PDCD4 expression was correlated             with β-catenin expression in gastric carcinoma cell lines, but not with E-cadherin,             as the binding partner in the cell membrane.
authors: Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan.
authors: Takashi
authors: T
authors: Kakimoto
authors: Ryosuke
authors: R
authors: Shiraishi
authors: Ryuichi
authors: R
authors: Iwakiri
authors: Kazuma
authors: K
authors: Fujimoto
authors: Hirokazu
authors: H
authors: Takahashi
authors: Hiroshi
authors: H
authors: Hamajima
authors: Toshihiko
authors: T
authors: Mizuta
authors: Hiroyuki
authors: H
authors: Ideguchi
authors: Shuji
authors: S
authors: Toda
authors: Yoshihiko
authors: Y
authors: Kitajima
authors: Iwata
authors: I
authors: Ozaki
authors: Sachiko
authors: S
authors: Matsuhashi
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D051017:Apoptosis Regulatory Proteins / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D002462:Cell Membrane / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism*
chemical_list: D051017:Apoptosis Regulatory Proteins; C114487:PDCD4 protein, human; D016601:RNA-Binding Proteins; D051176:beta Catenin