title: Eukaryotic origin of a metabolic pathway in virus by horizontal gene transfer.
abstract: Horizontal gene transfer, the movement of genetic materials across the normal mating barriers between organisms occurs frequently and contributes significantly to the evolution of both eukaryotic and prokaryotic genomes. However, few concurrent transfers of functionally related genes implemented in a pathway from eukaryotes to prokaryotes are observed. Here, we did phylogenetic analyses to support that the genes, i.e. dihydrofolate reductase, glycine hydroxymethyltransferase, and thymidylate synthase involved in thymidylate metabolism, in Hz-1 virus were obtained from insect genome recently by independent horizontal gene transfers. In addition, five other related genes in nucleotide metabolism show evidences of horizontal gene transfers. These genes demonstrate similar expression pattern, and they may have formatted a functionally related pathway (e.g. thymidylate synthesis, and DNA replication) in Hz-1 virus. In conclusion, we provide an example of horizontal gene transfer of functionally related genes in a pathway to prokaryote from eukaryote.
authors: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, China.
authors: Dong-Dong
authors: DD
authors: Wu
authors: Ya-Ping
authors: YP
authors: Zhang
mesh_terms: D000818:Animals; D012831:Bombyx / Q000235:genetics* / Q000821:virology; D004261:DNA Replication; D022761:Gene Transfer, Horizontal; D005814:Genes, Viral; D049750:Genome, Insect; D012696:Glycine Hydroxymethyltransferase / Q000235:genetics / Q000378:metabolism; D007304:Insect Viruses / Q000145:classification / Q000201:enzymology* / Q000235:genetics / Q000502:physiology; D053858:Metabolic Networks and Pathways; D010802:Phylogeny; D020539:Sequence Analysis, Protein; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics / Q000378:metabolism; D013940:Thymidylate Synthase / Q000235:genetics / Q000378:metabolism; D014779:Virus Replication
chemical_list: D013762:Tetrahydrofolate Dehydrogenase; D013940:Thymidylate Synthase; D012696:Glycine Hydroxymethyltransferase