title: Investigation of pH-responsive properties of polymeric micelles with a core-forming block having pendant cyclic ketal groups.
abstract: In this study, three kinds of amphiphilic block copolymers, termed MPEG-block-PDMMA, MPEG-block-PCPMA, and MPEG-block-PMPMA, which were composed of one hydrophilic monomethoxy poly(ethylene glycol) (MPEG) block and one hydrophobic polyacrylate block bearing pendant six-member cyclic ketal groups, were synthesized by atom transfer radical polymerization (ATRP). These polymers can disperse in aqueous media to self-assemble into micellar aggregates with a spherical core-shell structure with mean diameter below 300 nm. The stimuli-responsiveness of polymeric micelles from MPEG-block-PDMMA was detected by fluorescence-probe technique at pH 3.5 and 37 °C. The effect of chemical architecture and composition of the polymers on the pH-responsive properties of polymeric micelles was also studied. A combination of pH and temperature to trigger release behavior of these polymeric micelles was discussed by comparing the encapsulated molecule release ability under various pH and temperature conditions and analyzing chemical structural changes of the polymer before and after the triggering.
authors: State Key Laboratory of Chemical Resource, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
authors: Shan
authors: S
authors: Jiang
authors: Yuan
authors: Y
authors: Yao
authors: Yanzhao
authors: Y
authors: Nie
authors: Junjiao
authors: J
authors: Yang
authors: Jing
authors: J
authors: Yang
mesh_terms: D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry*; D013141:Spiro Compounds / Q000737:chemistry*
chemical_list: D008823:Micelles; D011108:Polymers; D013141:Spiro Compounds