title: Nanosuspensions as advanced printing ink for accurate dosing of poorly soluble drugs in personalized medicines.
abstract: Folic acid was used as a model drug to demonstrate the advantages of formulating poorly soluble drugs as nanosuspensions and their use in an inkjet-type printing technique to produce personalized medicines. 10% folic acid nanosuspensions stabilized with Tween 20, a stabilizer showing the best wetting potential for folic acid, were prepared via high pressure homogenization. The particle size of the folic acid nanosuspension was well below 5 μm being a prerequisite for inkjet type printing technique. A good reproducibility of the particle size of folic acid nanosuspension prepared via high pressure homogenization was found. As indicated by the zeta potential the formulation showed a good storage stability. High pressure homogenization had no influence on the crystalline state of folic acid. An increase in the saturation solubility by 53.7% was found reducing the particle size from the micrometer range to the nanometer range. The dissolution velocity of the folic acid nanosuspension was significantly enhanced compared to a folic acid suspension, i.e. after 5 min 78.6% of the folic acid was dissolved from the nanosuspension and only 6.2% from the suspension. Moreover, the printing of 10% folic acid nanosuspension could be successfully demonstrated.
authors: Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology, Karl-Franzens Universität Graz, Universitätsplatz 1, 8010 Graz, Austria. jana.pardeike@uni-graz.at
authors: Jana
authors: J
authors: Pardeike
authors: Daniela M
authors: DM
authors: Strohmeier
authors: Nina
authors: N
authors: Schrödl
authors: Christine
authors: C
authors: Voura
authors: Michael
authors: M
authors: Gruber
authors: Johannes G
authors: JG
authors: Khinast
authors: Andreas
authors: A
authors: Zimmer
mesh_terms: D000284:Administration, Oral; D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D004304:Dosage Forms; D004339:Drug Compounding; D054796:Drug Dosage Calculations; D004355:Drug Stability; D005079:Excipients / Q000737:chemistry; D005492:Folic Acid / Q000008:administration & dosage / Q000737:chemistry*; D006801:Humans; D007700:Kinetics; D053758:Nanoparticles; D036103:Nanotechnology; D011136:Polysorbates / Q000737:chemistry; D057285:Precision Medicine / Q000379:methods*; D011312:Pressure; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods*; D014906:Wetting Agents / Q000737:chemistry
chemical_list: D004304:Dosage Forms; D005079:Excipients; D011136:Polysorbates; D014906:Wetting Agents; D005492:Folic Acid