title: [Comparative pharmacokinetics of antigrippin-maximum administered in capsules and powder for preparing solutions].
abstract: Comparative pharmacokinetics of anti-influenza drug composition Antigrippin-maximum administered in capsules and a powder for preparing solutions has been studied after single administraton in a group of 18 healthy volunteers. Both preparations [manufactured by the Antiviral Research and Production Corporation (St Petersbutg) contain 6 active components, including paracetamol, rimantadine, loratadine, ascorbic acid, calcium gluconate, and rutoside in equal amounts. The concentrations of unchanged paracetamol, rimantadine, and loratadine in the blood plasma were degtermined by HPLC with mass-spectrometric and UV detection. The pharmacokinetic parameters of allindicated active components exhibited no detectable distinctions, except for the time to attaining maximum concentration ofparacetamol and the value of the maximum concentration of loratadine.
authors: V G
authors: VG
authors: Belolipetskaia
authors: S V
authors: SV
authors: Blagodatskikh
authors: E A
authors: EA
authors: Zhabina
authors: D A
authors: DA
authors: Kibalchich
authors: D F
authors: DF
authors: Guranda
authors: N A
authors: NA
authors: Belolipetskiĭ
authors: L I
authors: LI
authors: Rudenko
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001682:Biological Availability; D002214:Capsules / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004338:Drug Combinations; D005260:Female; D006207:Half-Life; D006801:Humans; D007251:Influenza, Human / Q000188:drug therapy / Q000821:virology; D017336:Loratadine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D013058:Mass Spectrometry; D009975:Orthomyxoviridae / Q000187:drug effects; D011208:Powders / Q000737:chemistry*; D012299:Rimantadine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D012426:Russia; D012996:Solutions / Q000737:chemistry
chemical_list: D000998:Antiviral Agents; D002214:Capsules; D004338:Drug Combinations; D011208:Powders; D012996:Solutions; D012299:Rimantadine; D000082:Acetaminophen; D017336:Loratadine