title: Altered patterns of brain activity during transient sadness in children at familial risk for major depression.
abstract: BACKGROUND
  We used functional magnetic resonance imaging (fMRI) to investigate the neural correlates of sadness, the prevailing mood in major depression (MD), in a prospective, well-documented community sample followed since birth.
  
  
  METHODS
  The children, comprising 136 children (65 boys and 71 girls) of mothers with varying levels of depressive symptomatology, were scanned - using a 1.5-Tesla system - while they watched 5 blocks of both sad and neutral film excerpts. Following scanning, they rated the emotions they experienced, and if they identified sadness, they were also asked to rate its intensity.
  
  
  RESULTS
  In children whose mothers exhibited higher depressive symptomatology, compared to children whose mothers displayed lower depressive symptomatology, altered neural responses to sad film excerpts were noted in brain regions known to be involved in sadness and MD, notably the insula, anterior cingulate cortex and caudate nucleus, even though the children did not differ in current mood.
  
  
  CONCLUSIONS
  Whether this represents genetic vulnerability or a consequence of exposure to maternal depressive symptoms at a young age is unknown.
  
  
  CONCLUSIONS
  The results are consistent with the results of studies in healthy adults and MD patients. The present study suggests that an altered pattern of regional brain responses to sad stimuli, is already present in childhood and might represent vulnerability for MD later in life.
authors: CHU Sainte-Justine Research Centre, Montreal, Canada.
authors: Mélissa L
authors: ML
authors: Lévesque
authors: Mario
authors: M
authors: Beauregard
authors: Koen W
authors: KW
authors: Ottenhof
authors: Emilie
authors: E
authors: Fortier
authors: Richard E
authors: RE
authors: Tremblay
authors: Mara
authors: M
authors: Brendgen
authors: Daniel
authors: D
authors: Pérusse
authors: Ginette
authors: G
authors: Dionne
authors: Philippe
authors: P
authors: Robaey
authors: Frank
authors: F
authors: Vitaro
authors: Michel
authors: M
authors: Boivin
authors: Linda
authors: L
authors: Booij
mesh_terms: D000293:Adolescent; D000328:Adult; D000339:Affect / Q000502:physiology; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D003863:Depression; D003866:Depressive Disorder / Q000175:diagnosis / Q000523:psychology; D003865:Major Depressive Disorder / Q000235:genetics* / Q000503:physiopathology* / Q000523:psychology; D004644:Emotions / Q000502:physiology*; D005260:Female; D020022:Genetic Predisposition to Disease; D006179:Gyrus Cinguli / Q000503:physiopathology; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D011446:Prospective Studies; D055815:Young Adult