title: Neuroadaptive changes in cerebellar neurons induced by chronic exposure to IL-6.
abstract: IL-6 is an important signaling molecule in the CNS. CNS neurons express IL-6 receptors and their signal transduction molecules, consistent with a role for IL-6 in neuronal physiology. Research indicates that IL-6 levels are low in the normal brain but can be significantly elevated in CNS injury and disease. Relatively little is known about how the elevated levels of IL-6 affect neurons. In the current study we show that under conditions of chronic exposure, IL-6 induces alterations in the level of protein expression in developing CNS cells. Such changes may play a role in the altered CNS function observed in CNS conditions associated with elevated levels of IL-6 in the CNS.
authors: Molecular and Integrative Neuroscience Department, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA. gruol@scripps.edu
authors: D L
authors: DL
authors: Gruol
authors: A
authors: A
authors: Puro
authors: C
authors: C
authors: Hao
authors: P
authors: P
authors: Blakely
authors: E
authors: E
authors: Janneke
authors: K
authors: K
authors: Vo
mesh_terms: D000222:Adaptation, Physiological / Q000276:immunology*; D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D002478:Cells, Cultured; D002525:Cerebellar Cortex / Q000166:cytology* / Q000276:immunology* / Q000378:metabolism; D005260:Female; D015850:Interleukin-6 / Q000096:biosynthesis / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009457:Neuroglia / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D014176:Protein Biosynthesis / Q000276:immunology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000494:pharmacology; D013997:Time Factors
chemical_list: D015850:Interleukin-6; D011994:Recombinant Proteins