title: Anti-aquaporin-4 antibody-positive familial neuromyelitis optica in mother and daughter.
abstract: BACKGROUND
  Cases of anti-aquaporin (AQP)-4 antibody-positive familial neuromyelitis optica (NMO) in mothers and daughters are described.
  
  
  METHODS
  The demographic, clinical, neuroimaging, and anti-AQP-4 antibody status were investigated in four patients from two Asian families with anti-AQP-4 antibody-positive NMO.
  
  
  METHODS
  NMO was diagnosed in both mothers and daughters using the latest diagnostic criteria. All patients were anti-AQP-4 antibody-positive, and only one had an autoimmune background. The Japanese family presented with a poor visual outcome due to multiple occurrences of optic neuritis, whereas the Korean family presented with a good visual outcome. Disease onset occurred at different ages, even within the same family.
  
  
  CONCLUSIONS
  These cases may enhance the understanding of the genetic contribution to NMO. Our findings suggest that familial history must be carefully examined in patients with NMO.
authors: Department of Ophthalmology, Jikei University School of Medicine, 3-25-8 Nishishimbashi, Minato-ku, Tokyo 105-8461, Japan.
authors: Shoyo
authors: S
authors: Yoshimine
authors: Tsutomu
authors: T
authors: Sakai
authors: Mikihide
authors: M
authors: Ogasawara
authors: Keigo
authors: K
authors: Shikishima
authors: Hiroshi
authors: H
authors: Tsuneoka
authors: Keiko
authors: K
authors: Tanaka
mesh_terms: D000328:Adult; D000368:Aged; D051401:Aquaporin 4 / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002574:Cervical Vertebrae / Q000473:pathology; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008279:Magnetic Resonance Imaging; D009035:Mothers; D009471:Neuromyelitis Optica / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology*; D009679:Nuclear Family; D010375:Pedigree; D010956:Plasmapheresis; D014792:Visual Acuity
chemical_list: C496030:AQP4 protein, human; D051401:Aquaporin 4; D001323:Autoantibodies; D015415:Biomarkers; D005938:Glucocorticoids; D007074:Immunoglobulin G