title: Synthesis of 6-substituted-4-hydroxy-2-pyridinones via intramolecular ketene trapping of functionalized enamine-dioxinones.
abstract: The synthesis of various 6-substituted-4-hydroxy-2-pyridinones is reported. The functionalized keto-dioxinones were constructed via a diethylzinc mediated crossed Claisen condensation reaction and subsequent enamine formation, thermolysis, and cyclization-aromatization providing the pyridinone unit.
authors: Department of Chemistry, Imperial College, London SW7 2AZ, UK.
authors: Bhavesh H
authors: BH
authors: Patel
authors: Andrew M
authors: AM
authors: Mason
authors: Anthony G M
authors: AG
authors: Barrett
mesh_terms: D003500:Cyclization; D005030:Ethylenes / Q000737:chemistry*; D006900:Hydroxylation; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D015125:Oxyquinoline / Q000737:chemistry*; D011728:Pyridones / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D005030:Ethylenes; D007659:Ketones; D011728:Pyridones; D015125:Oxyquinoline; C008223:ketene