title: [Polymorphisms of 2B-adrenergic receptor and endothelial NO-Synthase genes in genesis of the hereditary sick sinus node syndrome].
abstract: In this work we have demonstrated for the first time on the clinico-genetic material association between hereditary sick sinus node syndrome (SSNS) ADRA2B and eNOS genes polymorphisms. We have established predominance of homozygote genotype of more rare DD allele in patients with SSNS (28%) compared with subjects of control group (8.99%). We have found predominance of heterozygote genotype 4a/4b in patients with SSNS compared with subjects of control group (41.8 and 25.39%, respectively). The data obtained allow to suggest that eNOS gene polymorphism might be associated with SSNS.
authors: A A
authors: AA
authors: Chernova
authors: S Iu
authors: SIu
authors: Nikulina
authors: V A
authors: VA
authors: Shul'man
authors: T S
authors: TS
authors: Kukushkina
authors: M I
authors: MI
authors: Voevoda
authors: V N
authors: VN
authors: Maksimov
mesh_terms: D000328:Adult; D000483:Alleles; D004562:Electrocardiography; D005260:Female; D020022:Genetic Predisposition to Disease; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D011110:Polymorphism, Genetic; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*; D012804:Sick Sinus Syndrome / Q000175:diagnosis / Q000235:genetics*; D012849:Sinoatrial Node / Q000002:abnormalities*
chemical_list: C547771:ADRA2B protein, human; D018341:Receptors, Adrenergic, alpha-2; C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III