title: Loss of 6q or 8p23 is associated with the total number of DNA copy number             aberrations in adenoid cystic carcinoma.
abstract: We analyzed 10 adenoid cystic carcinomas (ACCs) of the salivary glands by             array-based comparative genomic hybridization (a-CGH) using DNA chips spotted             with 4,030 bacterial artificial chromosome clones. After the data smoothing procedure             was applied, a total of 88 DNA copy number aberrations (DCNAs) were detected.             The frequent (≥30%) DCNAs were loss of 6q23-27 and 8p23, and gains of 6p, 6q23,             8p23 and 22q13. High-level gains were detected on 12q15, including MDM2 in two             cases. These two cases showed an immunohistochemically high-level (>50%) expression             of MDM2 and a low-level expression of p53 (<20%). Furthermore, the total number             of DCNAs was significantly greater in ACCs with loss of 6q compared to other ACCs,             and in ACCs without the loss of 8p23 compared to other ACCs, respectively. Although             limitations exist, a-CGH detected several candidate chromosomal imbalances associated             with accumulation of DCNAs in ACCs.
authors: Department of Pathology, Yamaguchi University School of Medicine, Minami-Kogushi 1-1-1, Ube-shi, Yamaguchi 755-8505, Japan. oga@yamaguchi-u.ac.jp
authors: Atsunori
authors: A
authors: Oga
authors: Kenichiro
authors: K
authors: Uchida
authors: Motonao
authors: M
authors: Nakao
authors: Shigeto
authors: S
authors: Kawauchi
authors: Tomoko
authors: T
authors: Furuya
authors: Yasuyo
authors: Y
authors: Chochi
authors: Kenzo
authors: K
authors: Ikemoto
authors: Takae
authors: T
authors: Okada
authors: Yoshiya
authors: Y
authors: Ueyama
authors: Kohsuke
authors: K
authors: Sasaki
authors: Fatemeh
authors: F
authors: Yousefpour
mesh_terms: D000368:Aged; D003528:Carcinoma, Adenoid Cystic / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002872:Chromosome Deletion; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8; D055028:Comparative Genomic Hybridization; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000378:metabolism; D056915:DNA Copy Number Variations; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D009006:Monosomy; D051736:Proto-Oncogene Proteins c-mdm2 / Q000378:metabolism; D012468:Salivary Gland Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D050759:Cyclin-Dependent Kinase Inhibitor p21; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2