title: HLA-B*27 allele associated to Behçet's disease and to anterior uveitis in Moroccan patients.
abstract: Human leukocyte antigen HLA-B51 is the most strongly associated gene with Behçet disease (BD) in different ethnic populations. We analyze the influence of HLA-B alleles in BD predisposition in Moroccan population and its association with clinical manifestations. The HLA-B phenotype frequencies were analyzed by serologic HLA class I typing and by polymerase chain reaction sequence-specific oligonucleotide (PCR-SSO) reverse dot blot hybridization in 120 unrelated Moroccan patients: all of whom fulfilled the international study group criteria for Behçet's disease, and in 112 ethnically matched healthy controls. Besides HLA-B*51 allele (20%), a significant increased frequency of the HLA-B*27 allele was found in Moroccans patients with Behçet's disease when compared to controls (13.3% of patients versus 2.7% of controls, chi square = 8.75, OR = 5.59, 95% IC [1.58-19.75] and particularly in the patients who presented an anterior uveitis (25% vs. 5.5%, p < 0.005).
authors: Laboratoire de physiologie et génétique moléculaire, Faculté des Sciences, Université Hassan II Aïn Chock, Maârif, Casablanca, Maroc.
authors: Asmaa
authors: A
authors: Radouane
authors: Mounia
authors: M
authors: Oudghiri
authors: Abdelfettah
authors: A
authors: Chakib
authors: Abdallah
authors: A
authors: Naya
authors: Abderrahman
authors: A
authors: Belhouari
authors: Abdelouhab
authors: A
authors: El Malki
authors: Siham
authors: S
authors: Bennani
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D001528:Behcet Syndrome / Q000235:genetics* / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D015796:HLA-B27 Antigen / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009018:Morocco; D010641:Phenotype; D016133:Polymerase Chain Reaction; D014606:Uveitis, Anterior / Q000235:genetics* / Q000276:immunology*
chemical_list: D015415:Biomarkers; D015796:HLA-B27 Antigen