title: Synthesis, characterization and cytotoxicity of mixed-ligand complexes of palladium(II) with 2, 2'-biquinoline/1, 4-diaminobutane and 4-toluenesulfonyl-L-amino acid dianion.
abstract: Seven new palladium(II) complexes (1-7) with 4-toluenesulfonyl-L-amino acid dianion and 2, 2'-biquinoline (bqu)/1,4-diaminobutane (dab) have been synthesized and characterized by elemental analysis, IR, (1)H NMR, and mass spectra techniques. Crystal structure of the complex (7) has been determined by X-ray diffraction analysis. The cytotoxicity was tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and sulforhodamine B (SRB) assays. The results indicate that the complexes exert cytotoxic effects with selectivity against tested carcinoma cell lines, but their cytotoxicity is less than that of cisplatin. It suggests that all the amino acids, N-containing ligands and metal ions have important effect on cytotoxicity, but the IC(50) values do not show definite correlation with variation of amino acids, N-containing ligands and metal ions, the cytotoxicity of complexes is related to tumor cell species.
authors: College of Chemistry & Environmental Science, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding 071002, China. jczhang6970@yahoo.com.cn
authors: Jinchao
authors: J
authors: Zhang
authors: Luwei
authors: L
authors: Li
authors: Lili
authors: L
authors: Ma
authors: Fangfang
authors: F
authors: Zhang
authors: Zhilei
authors: Z
authors: Zhang
authors: Shuxiang
authors: S
authors: Wang
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002073:Butanes / Q000737:chemistry*; D045744:Cell Line, Tumor; D060326:Chemistry Techniques, Synthetic; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D010165:Palladium / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D000970:Antineoplastic Agents; D002073:Butanes; D008024:Ligands; D009942:Organometallic Compounds; D011804:Quinolines; D010165:Palladium