title: An evaluation of the toxicity and bioaccumulation of cisplatin in the marine environment using the macroalga, Ulva lactuca.
abstract: The cytotoxic drug, cisplatin (cis-PtCl(2)(NH(3))(2)), has been added to cultures of the marine macroalga, Ulva lactuca, under various experimental conditions. Both accumulation and internalisation over a 48 h period was greater when cisplatin was added to coastal sea water (salinity = 33) from a distilled water solution than when added to either sea water or estuarine water (salinity = 16.5) from a saline solution. This effect is attributed to the greater abundance of the more reactive monoaqua complex (cis-PtCl(OH(2))(NH(3))(2)(+)) in the distilled water solution and kinetic constraints on its conversion back to cis-PtCl(2)(NH(3))(2) in sea water. Despite its mode of action at the cellular level, cisplatin added up to concentrations of 150 nM did not incur a measurable reduction in the efficiency of photochemical energy conversion under any of experimental conditions tested.
authors: School of Geography, Earth and Environmental Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK.
authors: Cecilia
authors: C
authors: Easton
authors: Andrew
authors: A
authors: Turner
authors: Graham
authors: G
authors: Sewell
mesh_terms: D000970:Antineoplastic Agents / Q000032:analysis / Q000378:metabolism* / Q000633:toxicity; D002945:Cisplatin / Q000032:analysis / Q000378:metabolism* / Q000633:toxicity; D004784:Environmental Monitoring / Q000379:methods*; D012623:Seawater / Q000032:analysis; D012624:Seaweed / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D044445:Ulva / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000378:metabolism* / Q000633:toxicity
chemical_list: D000970:Antineoplastic Agents; D014874:Water Pollutants, Chemical; D002945:Cisplatin