title: [Glossitis by mixed infection of cytomegalovirus and herpes simplex virus during therapy for pure red cell aplasia complicated with Good syndrome].
abstract: A 64-year-old man with a 10-year history of Good syndrome had been treated with periodic replacement of γ-globulin. He also had a 6-year history of lichen planus of the tongue. In 2009, the patient was diagnosed as having pure red cell aplasia (PRCA) based on bone marrow aspiration. Thymectomy was not effective. Then, immunosuppressive therapy with PSL and cyclosporine was initiated. Twenty days after treatment painful ulcer appeared on the left side of the tongue. Biopsy specimen of the ulcer demonstrated cells infected with cytomegalovirus and herpes simplex virus. Cytomegalovirus antigenemia was also positive. The tongue ulcer promptly improved after gancyclovir administration for a few weeks. Viral glossitis should be considered as part of the differential diagnoses of oral lesions not only in patients with HIV infection but also in those under immunosuppressive therapy.
authors: Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine.
authors: Hiroko
authors: H
authors: Koya
authors: Akihiko
authors: A
authors: Yokohama
authors: Ayaka
authors: A
authors: Miura
authors: Takumi
authors: T
authors: Hoshino
authors: Takeki
authors: T
authors: Mitsui
authors: Hiromi
authors: H
authors: Koiso
authors: Takayuki
authors: T
authors: Saitoh
authors: Hideki
authors: H
authors: Uchiumi
authors: Hiroshi
authors: H
authors: Handa
authors: Jyunko
authors: J
authors: Hirato
authors: Keijyu
authors: K
authors: Hiromura
authors: Masamitsu
authors: M
authors: Karasawa
authors: Hirokazu
authors: H
authors: Murakami
authors: Norifumi
authors: N
authors: Tsukamoto
authors: Yoshihisa
authors: Y
authors: Nojima
mesh_terms: D000361:Agammaglobulinemia / Q000188:drug therapy*; D000368:Aged; D060085:Coinfection; D016572:Cyclosporine / Q000627:therapeutic use; D003586:Cytomegalovirus Infections; D004359:Drug Therapy, Combination; D015774:Ganciclovir / Q000008:administration & dosage; D005928:Glossitis / Q000188:drug therapy / Q000821:virology*; D006561:Herpes Simplex; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D012010:Red-Cell Aplasia, Pure / Q000188:drug therapy*; D013577:Syndrome; D013945:Thymoma / Q000188:drug therapy*; D013953:Thymus Neoplasms / Q000188:drug therapy*; D005719:gamma-Globulins / Q000008:administration & dosage*
chemical_list: D007166:Immunosuppressive Agents; D005719:gamma-Globulins; D016572:Cyclosporine; D011239:Prednisolone; D015774:Ganciclovir