title: Genetic variant of HTR2A associates with risk of impulse control and repetitive behaviors in Parkinson's disease.
abstract: OBJECTIVE
  To determine the role of a serotonin 2A receptor gene (=HTR2A) variant in the development of impulse control and repetitive behaviors in Parkinson's disease.
  
  
  METHODS
  We performed a genetic association analysis to a cohort of 404 Korean patients with Parkinson's disease who had been enrolled in a previous study. Presence of impulse control and repetitive behaviors was screened using modified version of Minnesota Impulsive Disorders Interview and genotyping for HTR2A c.102T > C was performed using the TaqMan assay.
  
  
  RESULTS
  The T allele, which is presumably linked to higher receptor expression, was marginally associated with impulse control and repetitive behaviors in Parkinson's disease; the genetic influence was significantly enhanced in the lower levodopa-equivalent-dose group, increasing the risk by 2.8 and 6.9 times in CT and TT carriers, respectively (p-trend = 0.011). There was no significant interaction between the c.102T > C variant and clinical risk variables such as sex, age at onset, total daily levodopa-equivalent-dose, use of dopamine agonist and daily dose of dopamine agonist.
  
  
  CONCLUSIONS
  Our data support a possible contribution of genetic variation in the HTR2A to the susceptibility to impulse control and repetitive behaviors in Parkinson's disease.
authors: Department of Neurology, College of Medicine, Seoul National University Boramae Hospital, Seoul, South Korea.
authors: Jee-Young
authors: JY
authors: Lee
authors: Beom S
authors: BS
authors: Jeon
authors: Han-Joon
authors: HJ
authors: Kim
authors: Sung-Sup
authors: SS
authors: Park
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D015331:Cohort Studies; D012090:Cumulative Trauma Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies / Q000379:methods; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D012307:Risk Factors
chemical_list: D044402:Receptor, Serotonin, 5-HT2A