title: Diversity of HIV type 1 envelope (V3-V5) sequence in HIV type 1-infected Indian children.
abstract: Abstract   We assessed the viral envelope (V3-V5 region) sequence diversity from 13 HIV-1-infected Indian children from north India. All of the 13 children were found to be infected with subtype C viruses. One of the viral sequences exhibited usage of the CXCR4 coreceptor predicted by Web PSSM and Geno2pheno tools. This virus also had a longer V3 sequence with 37 amino acids, a GRGQ motif, and a methionine residue before it (AIIMS_307). A unique finding was the complete deletion of the V4 region of another virus (AIIMS_363). High sequence diversity was observed in the envelope of the HIV-1-infected Indian children.
authors: Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
authors: Somi Sankaran
authors: SS
authors: Prakash
authors: Rajesh
authors: R
authors: Kalra
authors: Rakesh
authors: R
authors: Lodha
authors: Sushil K
authors: SK
authors: Kabra
authors: Kalpana
authors: K
authors: Luthra
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D014644:Genetic Variation; D015699:HIV Envelope Protein gp120 / Q000235:genetics*; D006679:HIV Seropositivity / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007194:India; D007223:Infant; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D019713:Receptors, CCR5 / Q000235:genetics; D019718:Receptors, CXCR4 / Q000235:genetics
chemical_list: D015699:HIV Envelope Protein gp120; D019713:Receptors, CCR5; D019718:Receptors, CXCR4