title: Bilateral somatosensory cortex disinhibition in complex regional pain syndrome type I.
abstract: OBJECTIVE
  In a previous study, we found bilateral disinhibition in the motor cortex of patients with complex regional pain syndrome (CRPS). This finding suggests a complex dysfunction of central motor-sensory circuits. The aim of our present study was to assess possible bilateral excitability changes in the somatosensory system of patients with CRPS.
  
  
  METHODS
  We measured paired-pulse suppression of somatosensory evoked potentials in 21 patients with unilateral CRPS I involving the hand. Eleven patients with upper limb pain of non-neuropathic origin and 21 healthy subjects served as controls. Innocuous paired-pulse stimulation of the median nerve was either performed at the affected and the unaffected hand, or at the dominant hand of healthy controls, respectively.
  
  
  RESULTS
  We found a significant reduction of paired-pulse suppression in both sides of patients with CRPS, compared with control patients and healthy control subjects.
  
  
  CONCLUSIONS
  These findings resemble our findings in the motor system and strongly support the hypothesis of a bilateral complex impairment of central motor-sensory circuits in CRPS I.
authors: Department of Neurology, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil GmbH, Ruhr-University Bochum, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany. melanie.lenz@rub.de
authors: M
authors: M
authors: Lenz
authors: O
authors: O
authors: Höffken
authors: P
authors: P
authors: Stude
authors: S
authors: S
authors: Lissek
authors: P
authors: P
authors: Schwenkreis
authors: A
authors: A
authors: Reinersmann
authors: J
authors: J
authors: Frettlöh
authors: H
authors: H
authors: Richter
authors: M
authors: M
authors: Tegenthoff
authors: C
authors: C
authors: Maier
mesh_terms: D000328:Adult; D000368:Aged; D004558:Electric Stimulation / Q000379:methods; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009433:Neural Inhibition / Q000502:physiology*; D012019:Reflex Sympathetic Dystrophy / Q000175:diagnosis / Q000503:physiopathology*; D013003:Somatosensory Cortex / Q000503:physiopathology*; D055815:Young Adult