title: A new look at electrolyte transport in the distal tubule.
abstract: The distal nephron plays a critical role in the renal control of homeostasis. Until very recently most studies focused on the control of Na(+), K(+), and water balance by principal cells of the collecting duct and the regulation of solute and water by hormones from the renin-angiotensin-aldosterone system and by antidiuretic hormone. However, recent studies have revealed the unexpected importance of renal intercalated cells, a subtype of cells present in the connecting tubule and collecting ducts. Such cells were thought initially to be involved exclusively in acid-base regulation. However, it is clear now that intercalated cells absorb NaCl and K(+) and hence may participate in the regulation of blood pressure and potassium balance. The second paradigm-challenging concept we highlight is the emerging importance of local paracrine factors that play a critical role in the renal control of water and electrolyte balance.
authors: Centre de Recherche des Cordeliers, Université Paris Descartes, INSERM UMRS 872, Equipe 3, F-75006, Paris, France. dominique.eladari@crc.jussieu.fr
authors: Dominique
authors: D
authors: Eladari
authors: Régine
authors: R
authors: Chambrey
authors: Janos
authors: J
authors: Peti-Peterdi
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001692:Biological Transport / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D002712:Chlorides / Q000378:metabolism; D003106:Colon / Q000378:metabolism; D004232:Diuretics / Q000494:pharmacology; D004573:Electrolytes / Q000378:metabolism*; D017506:H(+)-K(+)-Exchanging ATPase / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007610:Kallikreins / Q000378:metabolism / Q000502:physiology; D007686:Kidney Tubules, Distal / Q000166:cytology / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism; D012084:Renin-Angiotensin System / Q000502:physiology; D015222:Sodium Channels / Q000502:physiology; D012965:Sodium Chloride / Q000378:metabolism; D049971:Thiazides / Q000494:pharmacology
chemical_list: D002712:Chlorides; D004232:Diuretics; D004573:Electrolytes; D015222:Sodium Channels; D049971:Thiazides; D012965:Sodium Chloride; D000255:Adenosine Triphosphate; D007610:Kallikreins; D017506:H(+)-K(+)-Exchanging ATPase; D011188:Potassium