title: Marine collagen peptides protect against early alcoholic liver injury in rats.
abstract: Marine collagen peptides (MCP) have been reported to exhibit antioxidative activity, which is the common property of numerous hepatoprotective agents. Previous studies have shown that MCP have biological functions including anti-hypertension, anti-ulcer, anti-skin ageing and extending the life span. However, its role in alcoholic liver injury remains unknown. The present study aimed to investigate the effects of MCP on early alcoholic liver injury in rats. Rats were administered with alcohol at a dose of 6 g/kg body weight intragastrically per d to induce early liver injury, which was then evaluated by serum markers and histopathological examination. Treatment with MCP could reverse the increased level of serum aminotransferase and reduce hepatic histological damage. In addition, MCP attenuated the alteration in serum superoxide dismutase and malondialdehyde levels. MCP also counteracted the increased levels of total cholesterol and TAG. However, no significant difference was observed in the contents of alcohol dehydrogenase both in liver and serum protein of rats. These findings suggest that MCP have a protective effect on early alcoholic liver injury in rats by their antioxidative activity and improving lipid metabolism.
authors: Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, People's Republic of China.
authors: Bing
authors: B
authors: Lin
authors: Feng
authors: F
authors: Zhang
authors: Yongchao
authors: Y
authors: Yu
authors: Qinghao
authors: Q
authors: Jiang
authors: Zhaofeng
authors: Z
authors: Zhang
authors: Junbo
authors: J
authors: Wang
authors: Yong
authors: Y
authors: Li
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000426:Alcohol Dehydrogenase / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000302:isolation & purification; D001219:Aspartate Aminotransferases / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D003094:Collagen / Q000008:administration & dosage* / Q000302:isolation & purification; D004195:Disease Models, Animal; D005260:Female; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008108:Liver Diseases, Alcoholic / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D008315:Malondialdehyde / Q000097:blood; D017685:Oncorhynchus keta; D010455:Peptides / Q000008:administration & dosage* / Q000302:isolation & purification; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000975:Antioxidants; D001798:Blood Proteins; D008055:Lipids; D010455:Peptides; D008315:Malondialdehyde; D003094:Collagen; D002784:Cholesterol; D000426:Alcohol Dehydrogenase; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase