title: [Bone and calcium metabolism in menopause transition].
abstract: Menopause, or estrogen deficiency, predispose women towards fragility fractures resulting from impaired bone strength, as the composite consequence of : (1) increased bone resorption caused by proliferation and activation of osteoclasts ; (2) dissociation of coupling bone formation with resorption ; (3) deterioration of bone quality ; (4) decreased calcium absorption from intestines and resorption from renal tubules. The current explanation of each phenomenon is described in this article, although the exact mechanisms have not been unanimously defined.
authors: Tokyo Medical and Dental University, Department of Obstetrics and Gynecology, Japan.
authors: Masakazu
authors: M
authors: Terauchi
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000209:etiology; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D049109:Cell Proliferation; D016207:Cytokines / Q000502:physiology; D004967:Estrogens / Q000172:deficiency / Q000502:physiology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000502:physiology; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology; D007408:Intestinal Absorption; D007684:Kidney Tubules / Q000378:metabolism; D008593:Menopause / Q000378:metabolism* / Q000502:physiology*; D051379:Mice; D010010:Osteoclasts / Q000166:cytology; D010012:Osteogenesis / Q000502:physiology; D058866:Osteoporotic Fractures / Q000209:etiology* / Q000517:prevention & control
chemical_list: D016207:Cytokines; D004967:Estrogens; D018836:Inflammation Mediators; D005640:Follicle Stimulating Hormone; D002118:Calcium