title: Prognostic tissue markers in melanoma.
abstract: Prognostic tissue markers in melanoma Prognosis for patients diagnosed with cutaneous melanoma is currently based upon histopathological features alone, although tumours which are morphologically similar can behave differently. Numerous putative biomarkers have been identified in an attempt to aid prognostication for primary melanoma, using methods which include immunhistochemistry, polymerase chain reaction (PCR), array comparative genomic hybridization (CGH) and gene expression arrays. Despite this wide body of research, no biomarkers for prognosis in melanoma have been translated or are close to translation into clinical practice. In this review selected prognostic biomarkers are evaluated and the factors influencing successful biomarker translation, including phases of biomarker development and study design, are explored in an attempt to highlight the current gap between prognostic melanoma biomarker research and clinical translation.
authors: Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK. dam18@le.ac.uk
authors: David A
authors: DA
authors: Moore
authors: J Howard
authors: JH
authors: Pringle
authors: Gerald S
authors: GS
authors: Saldanha
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D055028:Comparative Genomic Hybridization; D020869:Gene Expression Profiling; D005819:Genetic Markers; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008545:Melanoma / Q000235:genetics / Q000378:metabolism*; D016133:Polymerase Chain Reaction; D011379:Prognosis; D012878:Skin Neoplasms / Q000235:genetics / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D005819:Genetic Markers