title: Acquired haemophilia A in a woman with autoimmune hepatitis and systemic lupus erythematosus:  review of literature.
abstract: Acquired haemophilia A, secondary to systemic lupus erythematosus (SLE), is a rare bleeding diathesis. Here we report a 37-year-old woman with autoimmune hepatitis who developed SLE and acquired haemophilia caused by factor VIII (fVIII) inhibitors. She presented with spontaneous ecchymosis and haematuria. There were a prolongation of the activated partial thromboplastin time, reduced fVIII activity and a high titre of fVIII inhibitors. Therapeutic regimen was started with intravenous methylprednisolone pulse, continued with prednisolone, intravenous pulse cyclophosphamide and fresh frozen plasma. After 8 weeks, fVIII inhibitor assay was negative.
authors: Rheumatic Disease Research Center, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Zahra
authors: Z
authors: Rezaieyazdi
authors: Davood
authors: D
authors: Sharifi-Doloui
authors: Kamila
authors: K
authors: Hashemzadeh
authors: Abbas
authors: A
authors: Shirdel
authors: Hassan
authors: H
authors: Mansouritorghabeh
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D003520:Cyclophosphamide / Q000009:adverse effects; D004438:Ecchymosis / Q000097:blood / Q000150:complications; D005169:Factor VIII / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005260:Female; D006417:Hematuria / Q000097:blood / Q000150:complications; D006467:Hemophilia A / Q000097:blood* / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D019693:Hepatitis, Autoimmune / Q000097:blood* / Q000150:complications / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007275:Injections, Intravenous; D007492:Iran; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D008775:Methylprednisolone / Q000009:adverse effects; D010314:Partial Thromboplastin Time; D010949:Plasma / Q000276:immunology; D011239:Prednisolone / Q000009:adverse effects
chemical_list: D001323:Autoantibodies; D003520:Cyclophosphamide; D005169:Factor VIII; D011239:Prednisolone; D008775:Methylprednisolone