title: Genetic disparities in the development of type 2 diabetes among African Americans.
abstract: OBJECTIVE
  The purpose of this paper is to discover whether biological and genetic differences play an important role in the pathogenesis of developing type 2 diabetes in the African-American population
  
  
  METHODS
  Review of original studies and meta-analyses from Medline, PubMed, CINAHL, Scopus
  
  
  CONCLUSIONS
  It is now well established that the development of type 2 diabetes results from the interaction between the individuals' biological and genetic makeup and their environment. Even though some genetic variants have been found, the full genetic landscape of type 2 diabetes, especially among African-Americans, is not yet discovered. Further researches or studies on pathophysiology and genetic susceptibility to diabetes may suggest new therapeutic targets for the treatment and prevention of insulin resistance.
  
  
  CONCLUSIONS
  Considering genetics as a potential cause of type 2 diabetes may suggest new therapeutic targets for the treatment and prevention, and new detecting tools for the undiagnosed patients. Nurse practitioners may gain a better understanding of the particular genetic defect influencing individual health and create the appropriate care plan to achieve an optimal health outcome for a patient.
authors: School of Nursing, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Kanokwan.seeleang@jefferson.edu
authors: Kanokwan
authors: K
authors: Seeleang
mesh_terms: D050154:Adiposity; D001741:Black or African American / Q000706:statistics & numerical data*; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics* / Q000451:nursing; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D054624:Health Status Disparities; D006801:Humans; D007333:Insulin Resistance; D010597:Pharmacogenetics; D010641:Phenotype; D012307:Risk Factors; D014481:United States / Q000453:epidemiology