title: Canine parvovirus-2b-associated erythema multiforme in a litter of English Setter dogs.
abstract: Erythema multiforme (EM) was diagnosed in a litter of English Setter puppies. The puppies developed erythematous cutaneous lesions at the age of 2 weeks. Microscopically, there was individual keratinocyte apoptosis associated with lymphocyte exocytosis in all layers of the epidermis. Intranuclear viral inclusions were seen in multiple tissues and organs. Tissues from the tongue, lymph node, spleen, skin, and small intestine were positive for Canine parvovirus-2 (CPV-2) and negative for Canine distemper virus (CDV) and Canid herpesvirus 1 by fluorescent antibody test. Negative-staining electron microscopy detected parvovirus particles in the intestinal contents. The skin and small intestine were positive for CPV-2b and negative for CDV by polymerase chain reaction. The mucocutaneous junctions and small intestines stained positive for CPV by immunohistochemistry. The present report documents CPV-2b-associated EM in a litter of English Setters and substantiates the single previous report associating EM with CPV-2. The finding suggests that CPV should be considered as a possible cause of EM in dogs.
authors: The University of Georgia, College of Veterinary Medicine, Department of Pathology, Tifton Veterinary Diagnostic and Investigational Laboratory, 43 Brighton Road, Tifton, GA 31793, USA. mwoldem@uga.edu
authors: Moges
authors: M
authors: Woldemeskel
authors: Alan
authors: A
authors: Liggett
authors: Marcia
authors: M
authors: Ilha
authors: Jeremiah T
authors: JT
authors: Saliki
authors: Leslie P
authors: LP
authors: Johnson
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000821:virology; D004283:Dog Diseases / Q000175:diagnosis / Q000473:pathology / Q000821:virology*; D004285:Dogs / Q000821:virology; D004892:Erythema Multiforme / Q000209:etiology / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D005260:Female; D005455:Fluorescent Antibody Technique / Q000662:veterinary; D008297:Male; D008854:Microscopy, Electron / Q000662:veterinary; D010322:Parvoviridae Infections / Q000150:complications / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D017993:Parvovirus, Canine; D016133:Polymerase Chain Reaction / Q000662:veterinary; D012867:Skin / Q000473:pathology