title: Dynamic contrast-enhanced magnetic resonance imaging with Gd-EOB-DTPA for the evaluation of liver fibrosis in chronic hepatitis patients.
abstract: OBJECTIVE
  To develop a non-invasive MRI method for evaluation of liver fibrosis, with histological analysis as the reference standard.
  
  
  METHODS
  The study protocol was approved by the Institutional Review Board for Human Studies of our hospital, and written informed consent was obtained from all subjects. Seventy-nine subjects who received dynamic contrast-enhanced MRI (DCE-MRI) with Gd-EOB-DTPA were divided into three subgroups according to Metavir score: no fibrosis (n = 30), mild fibrosis (n = 34), and advanced fibrosis (n = 15). The DCE-MRI parameters were measured using two models: (1) dual-input single-compartment model for arterial blood flow (F (a)), portal venous blood flow, total liver blood flow, arterial fraction (ART), distribution volume, and mean transit time; and (2) curve analysis model for Peak, Slope, and AUC. Statistical analysis was performed with Student's t-test and the nonparametric Kruskal-Wallis test.
  
  
  RESULTS
  Slope and AUC were two best perfusion parameters to predict the severity of liver fibrosis (>F2 vs. ≦F2). Four significantly different variables were found between non-fibrotic versus mild-fibrotic subgroups: F (a), ART, Slope, and AUC; the best predictor for mild fibrosis was F (a) (AUROC:0.701).
  
  
  CONCLUSIONS
  DCE-MRI with Gd-EOB-DTPA is a noninvasive imaging, by which multiple perfusion parameters can be measured to evaluate the severity of liver fibrosis.
authors: Department of Radiology and Medical Imaging, National Taiwan University College of Medicine and Hospital, No. 7 Chung-Shan S. Rd, Taipei, Taiwan.
authors: Bang-Bin
authors: BB
authors: Chen
authors: Chao-Yu
authors: CY
authors: Hsu
authors: Chih-Wei
authors: CW
authors: Yu
authors: Shwu-Yuan
authors: SY
authors: Wei
authors: Jia-Horng
authors: JH
authors: Kao
authors: Hsuan-Shu
authors: HS
authors: Lee
authors: Tiffany Ting-Fang
authors: TT
authors: Shih
mesh_terms: D000328:Adult; D000465:Algorithms; D019540:Area Under Curve; D001783:Blood Flow Velocity; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006521:Hepatitis, Chronic / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008099:Liver / Q000098:blood supply* / Q000473:pathology; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D008111:Liver Function Tests; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D011446:Prospective Studies; D012372:ROC Curve; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
chemical_list: D003287:Contrast Media; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA