title: Use of ovotransferrin as an antimicrobial in turkeys naturally infected with Chlamydia psittaci, avian metapneumovirus and Ornithobacterium rhinotracheale.
abstract: Respiratory pathogens are difficult to control in large-scale turkey production. This report describes a clinical trial of antimicrobial ovoTF aerosol on a large Belgian turkey farm. ovoTF was administered to reduce Chlamydia psittaci (C. psittaci) infections and to study the impact of this action on the occurrence of Ornithobacterium rhinotracheale (O. rhinotracheale) and avian metapneumovirus (aMPV) infections. Two subsequent broods were included; (i) a control brood receiving no ovoTF and (ii) an ovoTF brood receiving ovoTF aerosol (5mg/animal) at the age of 2 weeks, continuing daily for 12 days. Twenty-four one-day-old toms of the control and ovoTF brood were tagged and monitored for 15 weeks. The control brood experienced two periods of respiratory disease, the first (2-3 weeks of age) due to C. psittaci and the second (8-17 weeks of age) in the presence of C. psittaci, O. rhinotracheale and maybe aMPV. Extensive antibiotic treatment was needed in 2, 8 and 9 week-old toms. In the ovoTF brood, toms stayed healthy until the age of 9 weeks, whereafter respiratory disease occurred in the presence of C. psittaci, O rhinotracheale and aMPV. OvoTF administration: (i) reduced the amount of C. psittaci in the air as demonstrated by bioaerosol monitoring, (ii) prevented respiratory disease during the first half of the brood period, (iii) was associated with 46% reduction of mortality, and (iv) reduced the antibiotic cost. Our results justify additional clinical trials to explore the use of this innovative antimicrobial strategy for poultry.
authors: Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, BE-9000 Ghent, Belgium.
authors: Caroline
authors: C
authors: Van Droogenbroeck
authors: Liesbeth
authors: L
authors: Dossche
authors: Toon
authors: T
authors: Wauman
authors: Sarah
authors: S
authors: Van Lent
authors: Thao T T
authors: TT
authors: Phan
authors: Delphine S A
authors: DS
authors: Beeckman
authors: Daisy
authors: D
authors: Vanrompay
mesh_terms: D000293:Adolescent; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002691:Chlamydophila psittaci; D003207:Conalbumin / Q000627:therapeutic use*; D005260:Female; D045826:Flavobacteriaceae Infections / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D006801:Humans; D008297:Male; D029121:Metapneumovirus; D045246:Ornithobacterium; D018184:Paramyxoviridae Infections / Q000150:complications / Q000662:veterinary*; D011201:Poultry Diseases / Q000188:drug therapy*; D009956:Psittacosis / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D012140:Respiratory Tract Diseases / Q000188:drug therapy*; D014422:Turkeys
chemical_list: D000900:Anti-Bacterial Agents; D003207:Conalbumin