title: Clinical value of FDG PET or PET/CT in urinary bladder cancer: a systemic review and meta-analysis.
abstract: OBJECTIVE
  The purpose of the current study was to conduct a systemic review and meta-analysis of the published literature to evaluate the diagnostic accuracy of FDG PET or PET/CT in urinary bladder cancer.
  
  
  METHODS
  The authors conducted a systematic MEDLINE search of articles published between January 2000 and December 2010. Two reviewers independently assessed the methodological quality of each study. We conducted a meta-analysis of pooled sensitivity and specificity in detecting primary and metastatic lesions of bladder cancer.
  
  
  RESULTS
  Six studies met the inclusion criteria. The pooled sensitivity and specificity of PET/CT for primary lesion detection of bladder cancer were 0.90 (95% CI: 0.70-0.99) and 1.00 (95% CI: 0.74-1.00), respectively. The pooled sensitivity and specificity of FDG PET or PET/CT for staging or restaging (metastatic lesions) of bladder cancer were 0.82 (95% CI: 0.72-0.89) and 0.89 (95% CI: 0.81-0.95), respectively.
  
  
  CONCLUSIONS
  The diagnostic accuracy of FDG PET or PET/CT is good in metastatic lesions of urinary bladder cancer. Due to the small number of patients and limited number of studies analyzed, the diagnostic capability of FDG PET or PET/CT in detection of primary bladder wall lesions could not be assessed.
authors: Department of Nuclear Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
authors: Yu-Yu
authors: YY
authors: Lu
authors: Jin-Hua
authors: JH
authors: Chen
authors: Ji-An
authors: JA
authors: Liang
authors: Hsin-Yi
authors: HY
authors: Wang
authors: Cheng-Chieh
authors: CC
authors: Lin
authors: Wan-Yu
authors: WY
authors: Lin
authors: Chia-Hung
authors: CH
authors: Kao
mesh_terms: D019788:Fluorodeoxyglucose F18; D006801:Humans; D064847:Multimodal Imaging / Q000379:methods*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18