title: Inclusion body myositis.
abstract: OBJECTIVE
  Sporadic inclusion body myositis (sIBM) is a poorly understood immune and degenerative disease of skeletal muscle. Here, current opinion of the nature of this disease is summarized.
  
  
  RESULTS
  Recent findings for sIBM include further characterization of muscle involvement through magnetic resonance imaging, the role of muscle as a host for immune cells, progress in the role of extranuclear TDP-43 in causing cellular injury, and the discovery of a new sIBM autoantibody.
  
  
  CONCLUSIONS
  sIBM understanding continues to advance, with progress regarding the mechanism of this disease.
authors: Division of Neuromuscular Disease, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. sagreenberg@partners.org
authors: Steven A
authors: SA
authors: Greenberg
mesh_terms: D001323:Autoantibodies / Q000097:blood; D001402:B-Lymphocytes / Q000276:immunology; D002467:Cell Nucleus / Q000473:pathology; D004268:DNA-Binding Proteins / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D018979:Myositis, Inclusion Body / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D001323:Autoantibodies; D004268:DNA-Binding Proteins