title: Risk factors for mortality in patients with Burkholderia cepacia complex bacteraemia.
abstract: BACKGROUND
  Over the last 2 decades, Burkholderia cepacia complex has emerged as a serious human pathogen, especially in critically ill patients. B. cepacia complex has been associated with increased morbidity and mortality in intensive care unit patients. However, in our literature search, we could not find studies on risk factors for mortality in patients with B. cepacia complex bacteraemia. Therefore, we investigated risk factors for mortality in B. cepacia complex bacteraemia.
  
  
  METHODS
  Clinical characteristics and laboratory parameters of 27 patients with 1 or more blood cultures positive for B. cepacia complex from January 2006 to October 2010 in Severance Hospital, Yonsei University College of Medicine, Korea were retrospectively analyzed. The main outcome measure was overall 28-day mortality. Appropriate initial empirical antimicrobial use was defined as administration of agent(s) to which the organism was susceptible within 24 h of obtaining blood for culture.
  
  
  RESULTS
  The overall 28-day mortality rate was 41% (11/27). In univariate analysis, underlying diabetes mellitus (p = 0.033), inappropriate initial empirical antimicrobial therapy (p = 0.033), and an elevated Sequential Organ Failure Assessment (SOFA) score (p = 0.002) were significantly associated with mortality. In multivariate analysis, inappropriate initial empirical antimicrobial therapy and an elevated SOFA score were independent risk factors for increased mortality (p = 0.032 and p = 0.028, respectively).
  
  
  CONCLUSIONS
  An elevated SOFA score and inappropriate initial empirical antimicrobial therapy were significantly associated with adverse outcome in patients with B. cepacia complex bacteraemia.
authors: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors: Nam Su
authors: NS
authors: Ku
authors: Sang Hoon
authors: SH
authors: Han
authors: Chang Oh
authors: CO
authors: Kim
authors: Ji-Hyeon
authors: JH
authors: Baek
authors: Su Jin
authors: SJ
authors: Jeong
authors: Sung Joon
authors: SJ
authors: Jin
authors: Jun Yong
authors: JY
authors: Choi
authors: Young Goo
authors: YG
authors: Song
authors: June Myung
authors: JM
authors: Kim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000382:microbiology / Q000401:mortality*; D019121:Burkholderia Infections / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality*; D042602:Burkholderia cepacia complex; D003920:Diabetes Mellitus / Q000382:microbiology; D005260:Female; D006761:Hospitals; D006801:Humans; D008297:Male; D008875:Middle Aged; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D000900:Anti-Bacterial Agents