title: Light-controlled DNA binding of bisbenzamidines.
abstract: Caging of the amidinium moieties of two representative bisbenzamidine DNA binders with suitable photoresponsive protecting groups suppresses their DNA-binding, which can then be fully recovered upon irradiation with UV light that removes the caging groups, regenerating the parent compounds. Moreover, a caged aza-pentamidine (©1a) is inert against Candida albicans, but displays a potent growth inhibitory activity after irradiation with UV light.
authors: Departamento de Química Orgánica y Centro Singular de Investigación en Química Biológica y Materiales Moleculares, Unidad Asociada al CSIC, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
authors: Mateo I
authors: MI
authors: Sánchez
authors: Olalla
authors: O
authors: Vázquez
authors: M Eugenio
authors: ME
authors: Vázquez
authors: José L
authors: JL
authors: Mascareñas
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D006690:Bisbenzimidazole / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D008027:Light; D055668:Photochemical Processes
chemical_list: D000935:Antifungal Agents; D004247:DNA; D006690:Bisbenzimidazole