title: Effects of Passiflora edulis (yellow passion) on serum lipids and oxidative stress status of Wistar rats.
abstract: The aim of this study was to evaluate the effects of Passiflora edulis f. flavicarpa Degener (yellow passion) juice on the lipid profile and oxidative stress status of Wistar rats. Adult male Wistar rats were divided in two groups (n=8 animals per group): the control group, which received water, and the treated group, which was given P. edulis juice (1,000 mg/kg). Both groups received by gavage treatment twice a day for 28 days. The treated group showed an increased high-density lipoprotein-cholesterol level and decreased low-density lipoprotein-cholesterol and free fatty acid levels compared with the control group. Levels of triglycerides and and very low-density lipoprotein-cholesterol, superoxide dismutase activity, and total glutathione concentration were not statistically different between the two groups, but the thiobarbituric acid-reactive substances concentration (indicating lipid peroxidation) decreased in the treated group. These findings suggests that P. edulis juice in the experimental conditions used showed beneficial effects on lipid profile and improved lipid peroxidation in Wistar rats.
authors: Department of Pharmacology, School of Medicine and Health Sciences, University of Marília, Marília, São Paulo, Brazil. maricelma.soares.souza@gmail.com
authors: Maricelma da Silva Soares
authors: Mda S
authors: de Souza
authors: Sandra Maria
authors: SM
authors: Barbalho
authors: Débora Cristina
authors: DC
authors: Damasceno
authors: Marilza Vieira Cunha
authors: MV
authors: Rudge
authors: Kleber Eduardo
authors: KE
authors: de Campos
authors: Ana Carolina Goyos
authors: AC
authors: Madi
authors: Bruno Ribeiro
authors: BR
authors: Coelho
authors: Rodrigo César
authors: RC
authors: Oliveira
authors: Rodrigo Cartaxo
authors: RC
authors: de Melo
authors: Vinícius Castrequini
authors: VC
authors: Donda
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D005978:Glutathione / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects*; D008055:Lipids / Q000097:blood*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D029598:Passiflora; D028321:Plant Preparations / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D008055:Lipids; D028321:Plant Preparations; D013482:Superoxide Dismutase; D005978:Glutathione