title: Comparison of choroidal thickness among patients with healthy eyes, early age-related maculopathy, neovascular age-related macular degeneration, central serous chorioretinopathy, and polypoidal choroidal vasculopathy.
abstract: OBJECTIVE
  To compare choroidal thicknesses among eyes with early age-related maculopathy (ARM), neovascular age-related macular degeneration, polypoidal choroidal vasculopathy, and central serous chorioretinopathy.
  
  
  METHODS
  Patients with age-related maculopathy (37 eyes), neovascular age-related macular degeneration (24 eyes), polypoidal choroidal vasculopathy (12 eyes), and central serous chorioretinopathy (31 eyes) underwent spectral-domain optical coherence tomography evaluations using a choroid scanning protocol. A horizontal linear section comprising 50 averaged scans was obtained of each macula. The choroidal thickness was measured from the outer border of the retinal pigment epithelium to the inner scleral border. Twenty-nine subjects with healthy eyes served as a control group. Analysis of covariance tests were performed to evaluate the effects of various diagnoses on choroidal thickness after removal of variance (covariates = gender, age, and refractive error).
  
  
  RESULTS
  Among the different covariates, age was associated with choroidal thickness (fovea: F = 12.067, P = 0.001). After controlling for age differences, the choroid was thicker in polypoidal choroidal vasculopathy (319.92 ± 68.66 μm) and central serous chorioretinopathy (367.81 ± 105.56 μm) patients than in controls (241.97 ± 66.37 μm) and age-related maculopathy patients (186.62 ± 64.02 μm). However, there were no significant differences in mean choroidal thickness between neovascular age-related macular degeneration (226.46 ± 102.87 μm) and any of the other diagnoses.
  
  
  CONCLUSIONS
  The choroid was thicker in eyes with polypoidal choroidal vasculopathy or central serous chorioretinopathy than in control or age-related maculopathy groups.
authors: Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
authors: Seong-Woo
authors: SW
authors: Kim
authors: Jaeryung
authors: J
authors: Oh
authors: Soon-Sun
authors: SS
authors: Kwon
authors: Junho
authors: J
authors: Yoo
authors: Kuhl
authors: K
authors: Huh
mesh_terms: D000367:Age Factors; D000368:Aged; D056833:Central Serous Chorioretinopathy / Q000175:diagnosis*; D002829:Choroid / Q000033:anatomy & histology / Q000098:blood supply / Q000473:pathology*; D015862:Choroid Diseases / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000175:diagnosis*; D012016:Reference Values; D012189:Retrospective Studies; D012307:Risk Factors; D041623:Tomography, Optical Coherence; D057135:Wet Macular Degeneration / Q000175:diagnosis*