title: [Regulation of glucose and fatty acid metabolism in skeletal muscle during contraction].
abstract: The glucose-fatty acid cycle explains the preference for fatty acid during moderate and long duration physical exercise. In contrast, there is a high glucose availability and oxidation rate in response to intense physical exercise. The reactive oxygen species (ROS) production during physical exercise suggests that the redox balance is important to regulate of lipids/carbohydrate metabolism. ROS reduces the activity of the Krebs cycle, and increases the activity of mitochondrial uncoupling proteins. The opposite effects happen during moderate physical activity. Thus, some issues is highlighted in the present review: Why does skeletal muscle prefer lipids in the basal and during moderate physical activity? Why does glucose-fatty acid fail to carry out their effects during intense physical exercise? How skeletal muscles regulate the lipids and carbohydrate metabolism during the contraction-relaxation cycle?
authors: Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, SP, Brasil. lrs@icb.usp.br
authors: Leonardo R
authors: LR
authors: Silveira
authors: Carlos Hermano da Justa
authors: CH
authors: Pinheiro
authors: Claudio C
authors: CC
authors: Zoppi
authors: Sandro M
authors: SM
authors: Hirabara
authors: Kaio F
authors: KF
authors: Vitzel
authors: Reinaldo A
authors: RA
authors: Bassit
authors: Marina R
authors: MR
authors: Barbosa
authors: Igor H
authors: IH
authors: Sampaio
authors: Iracema H P
authors: IH
authors: Melo
authors: Jarlei
authors: J
authors: Fiamoncini
authors: Everardo M
authors: EM
authors: Carneiro
authors: Rui
authors: R
authors: Curi
mesh_terms: D000818:Animals; D004040:Dietary Carbohydrates / Q000378:metabolism; D015444:Exercise / Q000502:physiology*; D005227:Fatty Acids / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D004040:Dietary Carbohydrates; D005227:Fatty Acids; D017382:Reactive Oxygen Species; D005947:Glucose