title: [Fatty liver and hepatitis C virus infection].
abstract: Hepatitis C virus infection is a common liver disease worldwide, leading to the development of steatosis, cirrhosis and hepatocellular carcinoma. In patients with chronic hepatitis C virus infection the prevalence of steatosis has been estimated to be about 55%. Development of steatosis is due to both viral and metabolic factors. Hepatitis C virus proteins moderate a number of intracellular pathways, however, further studies are required to understand these mechanisms. Obesity and insulin resistance may allow the virus to resist antiviral treatment. This review discusses the relationship among steatosis, insulin resistance and the response to antiviral therapy.
authors: Semmelweis Egyetem, Általános Orvostudományi Kar Budapest.
authors: Marianna
authors: M
authors: Lakatos
authors: Krisztina
authors: K
authors: Hagymási
authors: Gabriella
authors: G
authors: Lengyel
mesh_terms: D052242:Adiponectin / Q000378:metabolism; D000998:Antiviral Agents / Q000627:therapeutic use*; D002352:Carrier Proteins / Q000378:metabolism; D018450:Disease Progression; D005234:Fatty Liver / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism* / Q000821:virology*; D019698:Hepatitis C, Chronic / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D007333:Insulin Resistance; D008113:Liver Neoplasms / Q000378:metabolism / Q000821:virology; D009765:Obesity / Q000150:complications* / Q000378:metabolism; D018384:Oxidative Stress; D047493:PPAR alpha / Q000378:metabolism; D015995:Prevalence; D011972:Receptor, Insulin / Q000378:metabolism; D047490:Retinoid X Receptor alpha / Q000378:metabolism; D012307:Risk Factors; D050826:Suppressor of Cytokine Signaling Proteins / Q000378:metabolism
chemical_list: D052242:Adiponectin; D000998:Antiviral Agents; D002352:Carrier Proteins; D047493:PPAR alpha; D047490:Retinoid X Receptor alpha; D050826:Suppressor of Cytokine Signaling Proteins; C106092:microsomal triglyceride transfer protein; D011972:Receptor, Insulin