title: Erythrocyte deformability and oxidative stress in inflammatory bowel disease.
abstract: BACKGROUND
  Oxidative stress and reduced microvascular flow are important factors in the pathogenesis of inflammatory bowel disease (IBD). The increased oxidative stress reduces the erythrocyte deformability. However, in IBD, there are no studies in the literature which evaluate erythrocyte deformability.
  
  
  OBJECTIVE
  In our study, we investigated the effect of oxidative stress and erythrocyte deformability in IBD.
  
  
  METHODS
  Forty-three patients with active IBD, 48 patients with inactive IBD and 45 healthy controls were included. The erytrocyte deformability, malonyldialdehyde levels, glutation peroxidase and sulfhydryl levels were measured in peripheral venous blood samples.
  
  
  RESULTS
  Erytrocyte malonyldialdehyde levels in both active and inactive IBD were significantly increased compared with control groups. Plasma glutation peroxidase levels did not show statistically significant difference between all groups. The decreased plasma sulfhydryl levels in active IBD were statistically significant compared with both the inactive IBD and the control group, but plasma sulfhydryl levels in inactive IBD group did not show statistically significant differences when compared with the control group. Elongation index values in both active and inactive IBD increased significantly compared with the control group. Statistically significant correlations were not found between the elongation index and glutation peroxidase, malonyldialdehyde, sulfhydryl levels in all groups.
  
  
  CONCLUSIONS
  Our study is the first to evaluate the erythrocyte deformability in IBD. In our study, increased erytrocyte malonyldialdehyde levels and decreased plasma sulfhydryl levels manifested the role of oxidative stress in the pathogenesis of the disease. It is thought that the increased erythrocyte malonyldialdehyde values cause the reduction in erythrocyte deformability.
authors: Department of Internal Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey. tulaytuzel@gmail.com
authors: Tulay
authors: T
authors: Akman
authors: Mesut
authors: M
authors: Akarsu
authors: Hale
authors: H
authors: Akpinar
authors: Halil
authors: H
authors: Resmi
authors: Ebru
authors: E
authors: Taylan
authors: Ebru
authors: E
authors: Sezer
mesh_terms: D000328:Adult; D004907:Erythrocyte Deformability / Q000502:physiology*; D004912:Erythrocytes / Q000737:chemistry; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000378:metabolism / Q000503:physiopathology*; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D018384:Oxidative Stress / Q000502:physiology*; D011446:Prospective Studies
chemical_list: D008315:Malondialdehyde