title: Dental implications of osteogenesis imperfecta: treatment with IV bisphosphonate: report of a case.
abstract: Osteogenesis imperfect (OI) is a group of genetically diverse connective tissue disorders. Bisphosphonates therapy to manage bone fragility, a now common medical therapy for OI, can increase the risk of bisphosphonate-associated osteonecrosis of the jaws. In this report, a 6 ½ year child, who was receiving bisphosphonate therapy for OI, underwent full mouth dental rehabilitation in the operating room while under general anesthesia. The child had numerous teeth restored and multiple primary molar extractions. The patient, who received prophylactic antibiotics intraoperatively, demonstrated no clinical signs of bisphosphonate-associated osteonecrosis when seen at follow-up. Although bisphosphonate osteonecrosis is a possible sequel in children who receive multiple extractions, no clinical signs were manifested in our patient, who required multiple primary tooth extractions along with restorative treatment under general anesthesia. While no dental guidelines have been developed to manage OI children having been treated with bisphosphonates, consent for extractions should include the risk of bone necrosis and careful post-operative observation to monitor wound healing.
authors: Associate clinical professor and graduate program director, University of North Carolina, Chapel Hill, NC, USA. Michael_Milano@dentistry.unc.edu
authors: Michael
authors: M
authors: Milano
authors: Timothy
authors: T
authors: Wright
authors: Karen J
authors: KJ
authors: Loechner
mesh_terms: D050071:Bone Density Conservation Agents / Q000008:administration & dosage*; D002675:Child, Preschool; D003793:Dental Restoration, Permanent; D004164:Diphosphonates / Q000008:administration & dosage*; D006801:Humans; D007275:Injections, Intravenous; D007571:Jaw Diseases / Q000139:chemically induced; D008297:Male; D010013:Osteogenesis Imperfecta / Q000188:drug therapy*; D010020:Osteonecrosis / Q000139:chemically induced; D000077268:Pamidronate; D012307:Risk Factors; D014081:Tooth Extraction
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D000077268:Pamidronate