title: ACGT: advancing clinico-genomic trials on cancer - four years of experience.
abstract: The challenges regarding seamless integration of distributed, heterogeneous and multilevel data arising in the context of contemporary, post-genomic clinical trials cannot be effectively addressed with current methodologies. An urgent need exists to access data in a uniform manner, to share information among different clinical and research centers, and to store data in secure repositories assuring the privacy of patients. Advancing Clinico-Genomic Trials (ACGT) was a European Commission funded Integrated Project that aimed at providing tools and methods to enhance the efficiency of clinical trials in the -omics era. The project, now completed after four years of work, involved the development of both a set of methodological approaches as well as tools and services and its testing in the context of real-world clinico-genomic scenarios. This paper describes the main experiences using the ACGT platform and its tools within one such scenario and highlights the very promising results obtained.
authors: Biomedical Informatics Group, Universidad Politécnica de Madrid, Spain. lmartin@infomed.dia.fi.upm.es
authors: Luis
authors: L
authors: Martin
authors: Alberto
authors: A
authors: Anguita
authors: Norbert
authors: N
authors: Graf
authors: Manolis
authors: M
authors: Tsiknakis
authors: Mathias
authors: M
authors: Brochhausen
authors: Stefan
authors: S
authors: Rüping
authors: Anca
authors: A
authors: Bucur
authors: Stelios
authors: S
authors: Sfakianakis
authors: Thierry
authors: T
authors: Sengstag
authors: Francesca
authors: F
authors: Buffa
authors: Holger
authors: H
authors: Stenzhorn
mesh_terms: D035843:Biomedical Research; D002986:Clinical Trials as Topic; D019295:Computational Biology / Q000458:organization & administration*; D003199:Computer Systems; D003201:Computers; D005060:Europe; D023281:Genomics; D006801:Humans; D008490:Medical Informatics / Q000458:organization & administration*; D009369:Neoplasms / Q000235:genetics; D016730:Program Development; D014584:User-Computer Interface; D057188:Workflow