title: Mechanical cavopulmonary assistance of a patient-specific Fontan physiology: numerical simulations, lumped parameter modeling, and suction experiments.
abstract: This study investigated the performance of a magnetically levitated, intravascular axial flow blood pump for mechanical circulatory support of the thousands of Fontan patients in desperate need of a therapeutic alternative. Four models of the extracardiac, total cavopulmonary connection (TCPC) Fontan configuration were evaluated to formulate numerical predictions: an idealized TCPC, a patient-specific TCPC per magnetic resonance imaging data, and each of these two models having a blood pump in the inferior vena cava (IVC). A lumped parameter model of the Fontan physiology was used to specify boundary conditions. Pressure-flow characteristics, energy gain calculations, scalar stress levels, and blood damage estimations were executed for each model. Suction limitation experiments using the Sylgard elastomer tubing were also conducted. The pump produced pressures of 1-16 mm Hg for 2000-6000 rpm and flow rates of 0.5-4.5 L/min. The pump inlet or IVC pressure was found to decrease at higher rotational speeds. Maximum scalar stress estimations were 3 Pa for the nonpump models and 290 Pa for the pump-supported cases. The blood residence times for the pump-supported cases were shorter (0.9 s) as compared with the nonsupported configurations (2.5 s). However, the blood damage indices were higher (1.5%) for the anatomic model with pump support. The pump successfully augmented pressure in the TCPC junction and increased the hydraulic energy of the TCPC as a function of flow rate and rotational speed. The suction experiments revealed minimal deformation (<3%) at 9000 rpm. The findings of this study support the continued design and development of this blood pump.
authors: Department of Mechanical Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA, USA. althrock@vcu.edu
authors: Amy L
authors: AL
authors: Throckmorton
authors: James P
authors: JP
authors: Carr
authors: Sharjeel A
authors: SA
authors: Tahir
authors: Ryan
authors: R
authors: Tate
authors: Emily A
authors: EA
authors: Downs
authors: Sonya S
authors: SS
authors: Bhavsar
authors: Yi
authors: Y
authors: Wu
authors: John D
authors: JD
authors: Grizzard
authors: William B
authors: WB
authors: Moskowitz
mesh_terms: D001243:Assisted Circulation / Q000295:instrumentation* / Q000379:methods; D003198:Computer Simulation; D004867:Equipment Design; D018729:Fontan Procedure / Q000295:instrumentation* / Q000379:methods; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D013396:Suction / Q000295:instrumentation; D014682:Vena Cava, Inferior / Q000601:surgery*