title: A highly efficient deprotection of the 2,2,2-trichloroethyl group at the anomeric oxygen of carbohydrates.
abstract: Commercially available zinc dust in the presence of ammonium chloride in acetonitrile at reflux removes the 2,2,2-trichloroethyl (TCE) group at anomeric centers with excellent yields (>95%) in short reaction times. This present method is easily implemented on substrates containing acyl and benzyl groups and large-scale reactions also proceed in high yield.
authors: Department of Chemistry, East China Normal University, Shanghai 200062, China. jbzhang@chem.ecnu.edu.cn
authors: Jianbo
authors: J
authors: Zhang
authors: Jie
authors: J
authors: Fu
authors: Wenshuai
authors: W
authors: Si
authors: Xiaohu
authors: X
authors: Wang
authors: Zhongfu
authors: Z
authors: Wang
authors: Jie
authors: J
authors: Tang
mesh_terms: D002241:Carbohydrates / Q000737:chemistry*; D007536:Isomerism; D007700:Kinetics; D010100:Oxygen / Q000737:chemistry*
chemical_list: D002241:Carbohydrates; D010100:Oxygen