title: Cellular oncomiR orthologue in EBV oncogenesis.
abstract: MicroRNAs are small non-coding RNAs that regulate gene expression at multiple levels. The discovery of virally encoded miRNAs attracted immense attention towards their role in viral replication and pathogenesis. Kaposi's-sarcoma-associated herpes virus encodes miRNA that functions as an orthologue of human cellular miRNA, i.e., hsa-miR-155. Keeping the same view we extended the miRNA-homology search between the miRNAs of humans and Epstein-Barr virus. The In silico analyses shows that EBV encoded miR-BART-5 has a significant 'seed' sequence homology to hsa-miR-18 of humans. Further, the mRNA transcripts of the human genes involved in cellular growth could potentially be targeted by both viral as well as human miRNAs. The known etiological role of hsa-miR-18 as an oncomiR suggests that miR-BART-5 may function as viral oncomiR as observed in EBV-positive gastric carcinoma patients.
authors: Department of Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh, India. sunil_gos@yahoo.com
authors: Sunil G
authors: SG
authors: Babu
authors: Sanket Singh
authors: SS
authors: Ponia
authors: Dinesh
authors: D
authors: Kumar
authors: Sangeeta
authors: S
authors: Saxena
mesh_terms: D001483:Base Sequence; D002472:Cell Transformation, Viral / Q000235:genetics*; D003198:Computer Simulation; D017124:Conserved Sequence; D044127:Epigenesis, Genetic; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D008957:Models, Genetic; D008969:Molecular Sequence Data; D009857:Oncogenes; D012367:RNA, Viral / Q000235:genetics* / Q000378:metabolism; D011965:Receptors, Glucocorticoid / Q000235:genetics; D016415:Sequence Alignment; D013274:Stomach Neoplasms / Q000235:genetics / Q000821:virology; D044763:Ubiquitin-Conjugating Enzymes / Q000235:genetics
chemical_list: C524942:MIRN155 microRNA, human; D035683:MicroRNAs; C497713:NR3C1 protein, human; D012367:RNA, Viral; D011965:Receptors, Glucocorticoid; C525243:UBE2Z protein, human; D044763:Ubiquitin-Conjugating Enzymes