title: [Expression and significance of P75 neurotrophin receptor in oral squamous cell carcinoma].
abstract: OBJECTIVE
  To investigate the expression of P75NTR in oral squamous cell carcinoma and evaluate the possibilities of P75NTR as a prognostic indicator of oral squamous cell carcinoma as well as a marker of cancer stem cell.
  
  
  METHODS
  SP immunohistochemical method was used to detect the expressions of tongue squamous cell carcinoma line Tca8113 and 43 surgically resected squamous cell carcinoma tissues. Five peri-carcinoma tissues and 8 normal tissues were selected as control. SPSS16.0 software package was applied for X(2) test.
  
  
  RESULTS
  P75NTR was positive in the Tca8113 cell line and located in the cell membrane. Thirty-three cases of the 43 OSCC patients showed positive expression of P75NTR. Para-carcinoma tissues and normal tissues showed negative expression of P75NTR. Positive P75NTR located in the cell membrane and dispersed in the cancer nest, and had a trend of cluster distribution. The expression of P75NTR had a relationship with tumor clinical stage(P<0.05) and lymph node metastasis(P<0.05).
  
  
  CONCLUSIONS
  The expression of P75NTR can predict the prognosis of oral squamous cell carcinoma, yet it can not be taken as a marker of cancer stem cell alone. Further study should be taken to investigate the role and mechanism of P75NTR in the development of tumor.
authors: Department of Oral and Maxillofacial Surgery, Shandong University, Jinan 250012, Shandong Province, China. fangxiang117@163.com
authors: Xiu-yin
authors: XY
authors: Wu
authors: Dong-dong
authors: DD
authors: Tong
authors: Feng-he
authors: FH
authors: Zhang
mesh_terms: D002294:Carcinoma, Squamous Cell; D006801:Humans; D008207:Lymphatic Metastasis; D009062:Mouth Neoplasms; D011379:Prognosis; D020800:Receptor, Nerve Growth Factor
chemical_list: D020800:Receptor, Nerve Growth Factor