title: Effect of the laxative magnesium oxide on gastrointestinal functional recovery in fast-track colonic resection: a double-blind, placebo-controlled randomized study.
abstract: OBJECTIVE
  A double-blind randomized controlled study was conducted to compare the effect of magnesium oxide (1 g 12-h) with placebo given within an evidence-based multimodal rehabilitation programme on gastrointestinal recovery, pain, mobilization and hospital stay after open colonic resection.
  
  
  METHODS
  Of 62 potentially eligible patients, 13 were excluded, leaving 22 in the magnesium oxide group and 27 in the placebo group. The main outcome measure was time to normalization of bowel function. Secondary outcome measures included postoperative nausea, vomiting, pain, fatigue, mobilization and length of postoperative hospital stay.
  
  
  RESULTS
  The median times to first flatus and defaecation in the laxative and placebo groups were 18.0 vs 14.0 h and 42 vs 50 h (P > 0.15). Early intake of liquids, protein drinks and solid food, nausea and vomiting, pain, fatigue and mobilization were similar in the groups (P > 0.3). The median postoperative hospital stay was 3 days in both groups (P > 0.65).
  
  
  CONCLUSIONS
  Magnesium oxide does not enhance the recovery of gastrointestinal function within the context of an evidence-based multimodal rehabilitation programme after open colonic surgery.
authors: Department of Surgical Gastroenterology, Hvidovre University Hospital, Copenhagen, Denmark. j.and@dadlnet.dk
authors: J
authors: J
authors: Andersen
authors: H
authors: H
authors: Christensen
authors: J H
authors: JH
authors: Pachler
authors: M
authors: M
authors: Hallin
authors: H V
authors: HV
authors: Thaysen
authors: H
authors: H
authors: Kehlet
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003106:Colon / Q000601:surgery*; D003672:Defecation / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D054368:Laxatives / Q000008:administration & dosage*; D007902:Length of Stay; D008277:Magnesium Oxide / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D020127:Recovery of Function; D018709:Statistics, Nonparametric; D013997:Time Factors
chemical_list: D054368:Laxatives; D008277:Magnesium Oxide