title: Exercise improves lung function and habitual activity in children with cystic fibrosis.
abstract: BACKGROUND
  Cystic fibrosis (CF) lung disease leads to progressive deterioration in exercise capacity. Because physical activity has been shown to improve lung function and quality of life (QoL), developing routine exercise programs can benefit this patient population.
  
  
  METHODS
  Lung function, nutritional status, and exercise capacity and assessments of habitual activity and QoL were measured before and after a two-month, subject-designed exercise regimen based on self-reported activity assessment. Statistical analysis included Wilcoxon signed-rank, Wilcoxon rank sum, and Fisher's exact tests.
  
  
  RESULTS
  Subjects completing the study demonstrated significant improvement in exercise capacity and body image perception, a CF-specific QoL measure (p<0.001). In secondary analyses, subjects improving exercise capacity showed significant increases in lung function and self-reported habitual activity.
  
  
  CONCLUSIONS
  Increases in exercise capacity over a two-month period resulted in significantly improved lung function and self-reported habitual activity. Longer, controlled trials are needed to develop individualized exercise recommendations.
authors: Eudowood Division of Pediatric Respiratory Sciences, Department of Pediatrics, Johns Hopkins University, Baltimore, MD 21287, USA. sparanj1@jhmi.edu
authors: Shruti M
authors: SM
authors: Paranjape
authors: Laura A
authors: LA
authors: Barnes
authors: Kathryn A
authors: KA
authors: Carson
authors: Karen
authors: K
authors: von Berg
authors: Holly
authors: H
authors: Loosen
authors: Peter J
authors: PJ
authors: Mogayzel
mesh_terms: D000293:Adolescent; D002648:Child; D003550:Cystic Fibrosis / Q000503:physiopathology*; D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy; D017079:Exercise Tolerance; D005260:Female; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D009043:Motor Activity / Q000502:physiology; D009752:Nutritional Status; D011788:Quality of Life; D012129:Respiratory Function Tests