title: HLA-dependent hypersensitivity reaction to nevirapine in Chinese Han HIV-infected patients.
abstract: In this study, one hundred and three HIV-positive Chinese Han patients treated with a nevirapine (NVP)-based regimens were investigated for the association between nevirapine hypersensitivity reaction (NVP HSR) and human leukocyte antigen (HLA) allele. HLA-Cw, -DRB1 alleles were determined in 32 NVP HSR cases and 71 NVP-tolerant patients. We found that considerable overlap was observed for the clinical and demographic characteristics of the 32 hypersensitive patients and 71 tolerant patients. Twelve out of 32 NVP HSR cases developed allergic hepatotoxicity. More HLA-Cw*04 alleles were observed in NVP HSR cases than in NVP-tolerant cases (p=0.029). The frequency of HLA-DRB1*15 in NVP-tolerant cases was significant higher than that in NVP HSR cases ( p=0.018). Multivariate logistic regression identified that HLA-Cw*04 presence was a risk factor related to NVP HSR (p=0.030, OR=3.611, 95% CI of OR: 1.135-11.489). To clearly understanding its value in clinical practice, further studies involving larger cohorts of patients from different races with different levels of immune suppression are needed.
authors: Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
authors: Shicheng
authors: S
authors: Gao
authors: Xi-En
authors: XE
authors: Gui
authors: Ke
authors: K
authors: Liang
authors: Zhang
authors: Z
authors: Liu
authors: Jinzhi
authors: J
authors: Hu
authors: Bo
authors: B
authors: Dong
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics / Q000276:immunology*; D000328:Adult; D000483:Alleles; D019380:Anti-HIV Agents / Q000009:adverse effects*; D044466:Asian People / Q000235:genetics; D018791:CD4 Lymphocyte Count; D004342:Drug Hypersensitivity / Q000453:epidemiology / Q000235:genetics / Q000276:immunology*; D005260:Female; D020022:Genetic Predisposition to Disease; D015236:HLA-C Antigens / Q000235:genetics / Q000276:immunology*; D059811:HLA-DRB1 Chains / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008297:Male; D019829:Nevirapine / Q000009:adverse effects* / Q000276:immunology; D015995:Prevalence; D012307:Risk Factors
chemical_list: D019380:Anti-HIV Agents; D015236:HLA-C Antigens; D059811:HLA-DRB1 Chains; D019829:Nevirapine