title: Hematological abnormalities in HIV-infected patients.
abstract: BACKGROUND
  Anemia, neutropenia, and thrombocytopenia are commonly observed in HIV-infected patients. This study was undertaken to evaluate the prevalence of cytopenias and their association with CD4 count. Furthermore, the association of hemoglobin concentration with mortality was also investigated.
  
  
  METHODS
  We reviewed the data of 701 HIV-infected patients followed at our institution. Blood cell counts, hemoglobin concentration, CD4 count, and viral load were recorded. We also recorded the mortality rate after 1 year in the groups with CD4 <200/μl and ≥ 200/μl according to hemoglobin concentration.
  
  
  RESULTS
  Of the total patients, 37.5% had anemia; 61.1% (110/180) were in the low CD4 group and 29.4% (153/521) were in the high CD4 group (p<0.01). Mean neutrophil counts were 2.610 × 10(9)/l and 3.204 × 10(9)/l in the low CD4 and high CD4 groups, respectively (p<0.01); mean platelet counts were 218.639 × 10(9)/l and 234.807 × 10(9)/l for the low CD4 and the high CD4 groups, respectively (p=0.03). Patients whose hemoglobin concentration was below the median value had a higher death rate in both the low CD4 (14 vs. 4 deaths, p=0.013) and high CD4 (8 vs. 1 death, p=0.0158) groups.
  
  
  CONCLUSIONS
  We found an association between CD4 count and hemoglobin level, neutrophil count, and platelet count, and that anemia was independently associated with a higher mortality.
authors: Center for Cell Based Therapy, Medical School of Ribeirão Preto, University of São Paulo, Rua Tenente Catão Roxo, 2501, Campus Universitário, CEP 14051-140, Ribeirão Preto, SP, Brazil. gil@hemocentro.fmrp.usp.br
authors: Gil Cunha
authors: GC
authors: De Santis
authors: Denise Menezes
authors: DM
authors: Brunetta
authors: Fernando Crivelenti
authors: FC
authors: Vilar
authors: Renata Amorim
authors: RA
authors: Brandão
authors: Renata Zomer
authors: RZ
authors: de Albernaz Muniz
authors: Geovana Momo Nogueira
authors: GM
authors: de Lima
authors: Manuela Emiliana
authors: ME
authors: Amorelli-Chacel
authors: Dimas Tadeu
authors: DT
authors: Covas
authors: Alcyone Artioli
authors: AA
authors: Machado
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000740:Anemia / Q000150:complications / Q000453:epidemiology; D019380:Anti-HIV Agents / Q000494:pharmacology; D001772:Blood Cell Count; D001938:Brazil / Q000453:epidemiology; D018791:CD4 Lymphocyte Count; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D015497:HIV-1 / Q000235:genetics / Q000302:isolation & purification*; D006402:Hematologic Diseases / Q000150:complications / Q000453:epidemiology*; D006454:Hemoglobins / Q000032:analysis / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000150:complications / Q000453:epidemiology; D012367:RNA, Viral / Q000097:blood; D012189:Retrospective Studies; D013921:Thrombocytopenia / Q000150:complications / Q000453:epidemiology; D019562:Viral Load; D055815:Young Adult; D015215:Zidovudine / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D006454:Hemoglobins; D012367:RNA, Viral; D015215:Zidovudine