title: Efficacy of antiplaque mouthwashes: a five-day clinical trial.
abstract: The aim of this study was to evaluate and compare the efficacy of antiplaque mouthwashes. Plaque levels were determined by applying a plaque-disclosing solution using the Turesky et al modification of the Quigley Hein plaque index. The control group (n = 6) brushed twice per day with fluoride toothpaste for one minute and rinsed with water, while the study groups (n = 6) brushed once per day with fluoride toothpaste for one minute, followed by rinsing with 5.0 mL of mouthwash diluted with 10.0 mL of water for 30 seconds. The control group brushed and rinsed with water twice per day. The results indicated that cetylpyridinium chloride in combination with sodium fluoride offered maximum plaque inhibition, followed by chlorhexidine gluconate and sodium monofluorophosphate, while plaque levels increased in the control group and with the combination of chlorhexidine gluconate and sodium fluoride. The only antiplaque agents to demonstrate a statistically significant difference from the control were cetylpyridinium chloride in combination with sodium fluoride, and chlorhexidine gluconate. Increasing the fluoride concentration had no impact on antiplaque activity.
authors: Department of Periodontology, Liaquat College of Medicine & Dentistry, Karachi, Pakistan.
authors: Muhammad Wasif
authors: MW
authors: Haq
authors: Mehwish
authors: M
authors: Batool
authors: Syed Hammad
authors: SH
authors: Ahsan
authors: Gaurav
authors: G
authors: Sharma
mesh_terms: D000293:Adolescent; D000328:Adult; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D002327:Cariostatic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002594:Cetylpyridinium / Q000008:administration & dosage / Q000627:therapeutic use; D002710:Chlorhexidine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D004396:Coloring Agents; D003773:Dental Plaque / Q000145:classification / Q000517:prevention & control*; D003774:Dental Plaque Index; D005459:Fluorides / Q000008:administration & dosage / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009067:Mouthwashes / Q000627:therapeutic use*; D010710:Phosphates / Q000008:administration & dosage / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000627:therapeutic use; D014100:Toothpastes / Q000627:therapeutic use; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000891:Anti-Infective Agents, Local; D002327:Cariostatic Agents; D004396:Coloring Agents; D009067:Mouthwashes; D010710:Phosphates; D014100:Toothpastes; C012980:fluorophosphate; D012969:Sodium Fluoride; D002594:Cetylpyridinium; C010882:chlorhexidine gluconate; D005459:Fluorides; D002710:Chlorhexidine