title: Enhanced transdermal delivery of indomethacin-loaded PLGA nanoparticles by iontophoresis.
abstract: Nanoparticles effectively deliver therapeutic agent by penetrating into the skin. Indomethacin (IM) and coumarin-6 were loaded in PLGA nanoparticles with an average diameter of 100 nm. IM and coumarin-6 were chosen as a model drug and as a fluorescent marker, respectively. The surfaces of the nanoparticles were negatively charged. Permeability of IM-loaded PLGA nanoparticles through rat skin was studied. Higher amount of IM was delivered through skin when IM was loaded in nanoparticles than IM was free molecules. Also, iontophoresis was applied to enhance the permeability of nanoparticles. When iontophoresis with 3 V/cm was applied, permeability of IM was much higher than that obtained by simple diffusion of nanoparticles through skin. The combination of charged nanoparticle system with iontophoresis is useful for effective transdermal delivery of therapeutic agents.
authors: Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki Noda Chiba 278-8510, Japan.
authors: Keishiro
authors: K
authors: Tomoda
authors: Hiroto
authors: H
authors: Terashima
authors: Kenichi
authors: K
authors: Suzuki
authors: Toshio
authors: T
authors: Inagi
authors: Hiroshi
authors: H
authors: Terada
authors: Kimiko
authors: K
authors: Makino
mesh_terms: D000818:Animals; D066298:In Vitro Techniques; D007213:Indomethacin / Q000008:administration & dosage* / Q000737:chemistry*; D007478:Iontophoresis / Q000379:methods*; D019344:Lactic Acid / Q000737:chemistry*; D008297:Male; D053758:Nanoparticles / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000378:metabolism*
chemical_list: D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D007213:Indomethacin