title: Eukaryotic gene prediction using GeneMark.hmm-E and GeneMark-ES.
abstract: This unit describes how to use the gene-finding programs GeneMark.hmm-E and GeneMark-ES for finding protein-coding genes in the genomic DNA of eukaryotic organisms. These bioinformatics tools have been demonstrated to have state-of-the-art accuracy for many fungal, plant, and animal genomes, and have frequently been used for gene annotation in novel genomic sequences. An additional advantage of GeneMark-ES is that the problem of algorithm parameterization is solved automatically, with parameters estimated by iterative self-training (unsupervised training).
authors: Georgia Institute of Technology, Atlanta, Georgia.
authors: Mark
authors: M
authors: Borodovsky
authors: Georgia Institute of Technology, Atlanta, Georgia.
authors: Alex
authors: A
authors: Lomsadze
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000379:methods*; D056890:Eukaryota / Q000235:genetics*; D005796:Genes / Q000235:genetics*; D016678:Genome / Q000235:genetics*; D020407:Internet; D008957:Models, Genetic; D012984:Software