title: Minimum information about a bioactive entity (MIABE).
abstract: Bioactive molecules such as drugs, pesticides and food additives are produced in large numbers by many commercial and academic groups around the world. Enormous quantities of data are generated on the biological properties and quality of these molecules. Access to such data - both on licensed and commercially available compounds, and also on those that fail during development - is crucial for understanding how improved molecules could be developed. For example, computational analysis of aggregated data on molecules that are investigated in drug discovery programmes has led to a greater understanding of the properties of successful drugs. However, the information required to perform these analyses is rarely published, and when it is made available it is often missing crucial data or is in a format that is inappropriate for efficient data-mining. Here, we propose a solution: the definition of reporting guidelines for bioactive entities - the Minimum Information About a Bioactive Entity (MIABE) - which has been developed by representatives of pharmaceutical companies, data resource providers and academic groups.
authors: (EMBL)-European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK. orchard@ebi.ac.uk
authors: Sandra
authors: S
authors: Orchard
authors: Bissan
authors: B
authors: Al-Lazikani
authors: Steve
authors: S
authors: Bryant
authors: Dominic
authors: D
authors: Clark
authors: Elizabeth
authors: E
authors: Calder
authors: Ian
authors: I
authors: Dix
authors: Ola
authors: O
authors: Engkvist
authors: Mark
authors: M
authors: Forster
authors: Anna
authors: A
authors: Gaulton
authors: Michael
authors: M
authors: Gilson
authors: Robert
authors: R
authors: Glen
authors: Martin
authors: M
authors: Grigorov
authors: Kim
authors: K
authors: Hammond-Kosack
authors: Lee
authors: L
authors: Harland
authors: Andrew
authors: A
authors: Hopkins
authors: Christopher
authors: C
authors: Larminie
authors: Nick
authors: N
authors: Lynch
authors: Romeena K
authors: RK
authors: Mann
authors: Peter
authors: P
authors: Murray-Rust
authors: Elena
authors: E
authors: Lo Piparo
authors: Christopher
authors: C
authors: Southan
authors: Christoph
authors: C
authors: Steinbeck
authors: David
authors: D
authors: Wishart
authors: Henning
authors: H
authors: Hermjakob
authors: John
authors: J
authors: Overington
authors: Janet
authors: J
authors: Thornton
mesh_terms: D000818:Animals; D015415:Biomarkers; D002617:Chemical Industry / Q000592:standards*; D002627:Chemistry, Physical; D003142:Communication; D003625:Data Collection; D015195:Drug Design; D004345:Drug Industry / Q000592:standards*; D017408:Guidelines as Topic; D006801:Humans; D033181:Information Dissemination; D010575:Pesticides; D004364:Pharmaceutical Preparations; D010599:Pharmacokinetics; D009626:Terminology as Topic; D014116:Toxicology
chemical_list: D015415:Biomarkers; D010575:Pesticides; D004364:Pharmaceutical Preparations