title: Distribution of yeast species associated with oral lesions in HIV-infected patients in Southwest Uganda.
abstract: Oropharyngeal candidiasis remains a significant clinical problem in HIV-infected and AIDS patients in regions of Africa where anti-retroviral therapy isn't readily available. In this study we identified the yeast populations associated with oral lesions in HIV-infected patients in Southwest Uganda who were receiving treatment with nystatin and topical clotrimazole. Samples were taken from 605 patients and 316 (52%) of these yielded yeast growth following incubation on Sabouraud dextrose agar. Samples were subsequently re-plated on CHROMagar Candida medium to facilitate identification of the yeast species present. The majority (56%) of culture-positive samples yielded a mix of two or more species. Candida albicans was present in 87% (274/316) of patient samples and accounted for 87% (120/138) of single species samples. Candida glabrata, Candida tropicalis and Candida norvegensis were also found in cultures that yielded a single species. No Candida dubliniensis isolates were identified in this population.
authors: School of Allied Health Sciences, Kampala International University, Republic of Uganda.
authors: Ezera
authors: E
authors: Agwu
authors: John C
authors: JC
authors: Ihongbe
authors: Brenda A
authors: BA
authors: McManus
authors: Gary P
authors: GP
authors: Moran
authors: David C
authors: DC
authors: Coleman
authors: Derek J
authors: DJ
authors: Sullivan
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000382:microbiology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage; D002175:Candida / Q000145:classification* / Q000302:isolation & purification*; D002180:Candidiasis, Oral / Q000188:drug therapy / Q000382:microbiology*; D002648:Child; D003022:Clotrimazole / Q000008:administration & dosage; D003470:Culture Media / Q000737:chemistry; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008828:Microbiological Techniques / Q000379:methods; D008875:Middle Aged; D009172:Mycology / Q000379:methods; D009761:Nystatin / Q000008:administration & dosage; D014454:Uganda; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D003470:Culture Media; D009761:Nystatin; D003022:Clotrimazole