title: High pentraxin 3 level predicts septic shock and bacteremia at the onset of febrile neutropenia after intensive chemotherapy of hematologic patients.
abstract: We evaluated pentraxin 3 as a marker for complications of neutropenic fever in 100 hematologic patients receiving intensive chemotherapy. Pentraxin 3 and C-reactive protein were measured at fever onset and then daily to day 3. Bacteremia was observed in 19 patients and septic shock in 5 patients (three deaths). In comparison to C-reactive protein, pentraxin 3 achieved its maximum more rapidly. Pentraxin 3 correlated not only with the same day C-reactive protein but also with the next day C-reactive protein. High pentraxin 3 on day 0 was associated with the development of septic shock (P=0.009) and bacteremia (P=0.046). The non-survivors had constantly high pentraxin 3 levels. To conclude, pentraxin 3 is an early predictor of complications in hematologic patients with neutropenic fever. High level of pentraxin 3 predicts septic shock and bacteremia already at the onset of febrile neutropenia. (ClinicalTrials.gov Identifier: NCT00781040.).
authors: Department of Medicine, Kuopio University Hospital, Kuopio, Finland.
authors: Matti
authors: M
authors: Vänskä
authors: Irma
authors: I
authors: Koivula
authors: Sari
authors: S
authors: Hämäläinen
authors: Kari
authors: K
authors: Pulkki
authors: Tapio
authors: T
authors: Nousiainen
authors: Esa
authors: E
authors: Jantunen
authors: Auni
authors: A
authors: Juutilainen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016470:Bacteremia / Q000175:diagnosis* / Q000209:etiology; D015415:Biomarkers / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced / Q000150:complications*; D011379:Prognosis; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D012772:Shock, Septic / Q000175:diagnosis* / Q000209:etiology; D014182:Transplantation, Autologous; D055815:Young Adult; D000099153:Pentraxins
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins