title: Blastic plasmacytoid dendritic cell neoplasm with leukemic presentation, lacking cutaneous involvement: Case series and literature review.
abstract: The diagnosis of blastic plasmacytoid dendritic cell neoplasm (BPDCN) can be challenging, owing to the absence of traditional lineage-specific markers, but is facilitated by CD4/CD56 co-expression and frequent skin involvement. Herein, we present our collective experiences with three BPDCN cases lacking cutaneous presentation and the inherent diagnostic pitfalls. Taken in context of similar historical cases, we suggest that BPDCN with "leukemic" presentation (L-BPDCN) otherwise presents no major distinguishing features and is at least as aggressive as its cutaneous-involved BPDCN counterpart.
authors: Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, ON, Canada.
authors: Michael J
authors: MJ
authors: Rauh
authors: Fazlur
authors: F
authors: Rahman
authors: David
authors: D
authors: Good
authors: Jeffrey
authors: J
authors: Silverman
authors: Michael K
authors: MK
authors: Brennan
authors: Nikolay
authors: N
authors: Dimov
authors: Jane
authors: J
authors: Liesveld
authors: Daniel H
authors: DH
authors: Ryan
authors: W Richard
authors: WR
authors: Burack
authors: John M
authors: JM
authors: Bennett
mesh_terms: D003713:Dendritic Cells / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D016130:Immunophenotyping; D015470:Leukemia, Myeloid, Acute / Q000145:classification / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000150:complications / Q000175:diagnosis / Q000473:pathology*