title: IL28B polymorphisms are not associated with the response to interferon-β in multiple sclerosis.
abstract: Recent studies have revealed an association between interleukin 28B (IL28B) and response to IFN-alpha treatment in hepatitis C patients. Here we investigated the influence of IL28B polymorphisms in the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. We genotyped two SNPs of the IL28B gene (rs8099917 and rs12979860) in 588 MS patients classified into responders (n=281) and non-responders (n=307) to IFNβ. Combined analysis of the study cohorts showed no significant associations between SNPs rs8099917 and rs12979860 and the response to treatment. These findings do not support a role of IL28B polymorphisms in the response to IFNβ in MS patients.
authors: Centre d'Esclerosi Múltiple de Catalunya, CEM-Cat, Unitat de Neuroimmunologia Clínica, Hospital Universitari Vall d'Hebron, Passeig Vall d'Hebron 119-129, Barcelona, Spain.
authors: S
authors: S
authors: Malhotra
authors: C
authors: C
authors: Morcillo-Suárez
authors: D
authors: D
authors: Brassat
authors: R
authors: R
authors: Goertsches
authors: J
authors: J
authors: Lechner-Scott
authors: E
authors: E
authors: Urcelay
authors: O
authors: O
authors: Fernández
authors: J
authors: J
authors: Drulovic
authors: A
authors: A
authors: García-Merino
authors: F
authors: F
authors: Martinelli Boneschi
authors: A
authors: A
authors: Chan
authors: K
authors: K
authors: Vandenbroeck
authors: A
authors: A
authors: Navarro
authors: M F
authors: MF
authors: Bustamante
authors: J
authors: J
authors: Río
authors: D A
authors: DA
authors: Akkad
authors: G
authors: G
authors: Giacalone
authors: A J
authors: AJ
authors: Sánchez
authors: L
authors: L
authors: Leyva
authors: R
authors: R
authors: Alvarez-Lafuente
authors: U K
authors: UK
authors: Zettl
authors: J
authors: J
authors: Oksenberg
authors: X
authors: X
authors: Montalban
authors: M
authors: M
authors: Comabella
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D006801:Humans; D016899:Interferon-beta / Q000502:physiology* / Q000627:therapeutic use; D007372:Interferons; D007378:Interleukins / Q000235:genetics*; D008297:Male; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000235:genetics / Q000276:immunology*; D020641:Polymorphism, Single Nucleotide; D000095022:Interferon Lambda
chemical_list: D016899:Interferon-beta; D007372:Interferons; D007378:Interleukins; C000624353:interferon-lambda, human; D000095022:Interferon Lambda