title: [Massive pulmonary embolism treated with selective infusion of tenecteplase].
abstract: Massive pulmonary embolism (PE) is a cardiovascular emergency due to a substantial obstruction of the pulmonary vascular bed, resulting in rapid right heart failure with a potentially fatal outcome.We present the case of a 50-year-old woman with massive PE and recent trans-sphenoid surgery because of pituitary adenoma. An occluding embolus, arising from deep venous thrombosis of the lower limbs, was demonstrated in the right pulmonary artery with selective angiography and treated with selective loco-regional infusion of low-dose tenecteplase. To the best of our knowledge, this is the first case of selective administration of low-dose tenecteplase in the pulmonary artery with successful resolution of PE without the need for adjunctive interventional procedures.
authors: U.O. di Cadiologia-UTIC, Ospedale Sun Giovanni de Dio, Agrigento. salvatoredirosa@gmail.com
authors: Salvatore
authors: S
authors: Di Rosa
authors: Giuseppe
authors: G
authors: Caramanno
authors: Calogero
authors: C
authors: Catalano
authors: Giuseppe
authors: G
authors: Andò
authors: Piero
authors: P
authors: Innocente
authors: Angelo
authors: A
authors: Cutaia
authors: Gabriella
authors: G
authors: Carlino
authors: Giovanni
authors: G
authors: Vaccaro
authors: Ignazio
authors: I
authors: Vaccaro
mesh_terms: D000236:Adenoma / Q000150:complications / Q000601:surgery; D015992:Body Mass Index; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006801:Humans; D036502:Infusions, Intralesional / Q000379:methods; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D010911:Pituitary Neoplasms / Q000150:complications / Q000601:surgery; D011651:Pulmonary Artery / Q000000981:diagnostic imaging; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D011859:Radiography; D012307:Risk Factors; D000077785:Tenecteplase; D013927:Thrombosis / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator; D000077785:Tenecteplase