title: Nickel-catalyzed sp2 C-H bonds arylation of N-aromatic heterocycles with Grignard reagents at room temperature.
abstract: A novel protocol for nickel-catalyzed direct sp(2) C-H bond arylation of purines has been developed. This new reaction proceeded efficiently at room temperature using Grignard reagent as the coupling partner within 5 hours in good to high yields. This approach provides a new access to a variety of C8-arylpurines which are potentially of great importance in medicinal chemistry.
authors: College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University, Xinxiang 453007, Henan, China. quguir@sina.com
authors: Gui-Rong
authors: GR
authors: Qu
authors: Peng-Yang
authors: PY
authors: Xin
authors: Hong-Ying
authors: HY
authors: Niu
authors: Dong-Chao
authors: DC
authors: Wang
authors: Rui-Fang
authors: RF
authors: Ding
authors: Hai-Ming
authors: HM
authors: Guo
mesh_terms: D002384:Catalysis; D007202:Indicators and Reagents / Q000737:chemistry; D008274:Magnesium / Q000737:chemistry*; D009532:Nickel / Q000737:chemistry*; D011687:Purines / Q000737:chemistry*; D013696:Temperature
chemical_list: D007202:Indicators and Reagents; D011687:Purines; D009532:Nickel; D008274:Magnesium