title: Cutting edge: virus selectively primes human langerhans cells for CD70 expression promoting CD8+ T cell responses.
abstract: The two outermost compartments of skin are populated by different Ag-presenting dendritic cell types. Epidermal Langerhans cells (LCs) are evolutionarily adapted to the continuous presence of harmless skin commensals by the selective lack of cell surface TLRs that sense bacteria. In this article, we analyze the ability of LCs and dermal dendritic cells (DDCs) to respond to virus infection. Live virus and intracellular TLR3-agonist dsRNA commit LCs more effectively than DDCs to stimulate naive CD8(+) T cell expansion and their differentiation into effector cells. This potent CD8(+) T cell-promoting capacity of LCs is causally related to high levels of virus-induced CD70 expression but not to IL-12 production. These data suggest a remarkable specialization of LCs in the induction of pathogen class-specific adaptive immunity. Whereas LCs ignore bacteria, they are superior to DDCs to initiate effective CD70-mediated CD8(+) T cells in response to virus stimulation.
authors: Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, 1105-AZ Amsterdam, The Netherlands.
authors: Angelic M G
authors: AM
authors: van der Aar
authors: Rosa
authors: R
authors: de Groot
authors: Marta
authors: M
authors: Sanchez-Hernandez
authors: Esther W M
authors: EW
authors: Taanman
authors: René A W
authors: RA
authors: van Lier
authors: Marcel B M
authors: MB
authors: Teunissen
authors: Esther C
authors: EC
authors: de Jong
authors: Martien L
authors: ML
authors: Kapsenberg
mesh_terms: D017951:Antigen Presentation / Q000276:immunology; D053282:CD27 Ligand / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D002469:Cell Separation; D003602:Cytotoxicity, Immunologic; D003713:Dendritic Cells / Q000276:immunology / Q000821:virology; D005434:Flow Cytometry; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007801:Langerhans Cells / Q000276:immunology* / Q000821:virology; D008213:Lymphocyte Activation / Q000276:immunology*; D012867:Skin / Q000166:cytology / Q000276:immunology
chemical_list: D053282:CD27 Ligand; C505771:CD70 protein, human