title: No significant association between SIRT1 gene and methamphetamine-induced psychosis in the Japanese population.
abstract: OBJECTIVE
  We previously showed that the sirtuin 1 gene (SIRT1 gene), one of the clock genes, was associated with schizophrenia in a Japanese patient population. Because the symptoms of methamphetamine (METH)-induced psychosis are similar to those of paranoid type schizophrenia and because not every METH user develops psychosis, it is conceivable that METH-induced psychosis and schizophrenia have common susceptibility genes. Therefore, we conducted an analysis of the association of SIRT1 gene with METH-induced psychosis, hypothesizing a significant relationship.
  
  
  METHODS
  This paper presents a case-control study of the SIRT1 gene in 515 Japanese individuals (197 with METH-induced psychosis and 318 age-matched and sex-matched controls) with four tagging single nucleotide polymorphisms (rs12778366, rs2273773, rs4746720, and rs10997875), selected a priori using the HapMap database.
  
  
  RESULTS
  rs10997875 (located in the 3' flanking region) was associated with METH-induced psychosis (unadjusted p(genotype)  = 0.0203). However, these results became non-significant after Bonferroni correction (corrected p(genotype)  = 0.0812). In the all-marker haplotype analysis, the SIRT1 gene was not associated with METH-induced psychosis (p = 0.146).
  
  
  CONCLUSIONS
  Our findings suggest that SIRT1 gene does not contribute to the development of METH-induced psychosis in the Japanese population. However, a replication study using larger samples should be conducted to obtain conclusive results.
authors: Department of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, New York 11004, USA. tarok@fujita-hu.ac.jp
authors: Taro
authors: T
authors: Kishi
authors: Yasuhisa
authors: Y
authors: Fukuo
authors: Tomo
authors: T
authors: Okochi
authors: Tsuyoshi
authors: T
authors: Kitajima
authors: Hiroshi
authors: H
authors: Ujike
authors: Toshiya
authors: T
authors: Inada
authors: Mitsuhiko
authors: M
authors: Yamada
authors: Naohisa
authors: N
authors: Uchimura
authors: Ichiro
authors: I
authors: Sora
authors: Masaomi
authors: M
authors: Iyo
authors: Norio
authors: N
authors: Ozaki
authors: Christoph U
authors: CU
authors: Correll
authors: Nakao
authors: N
authors: Iwata
mesh_terms: D000328:Adult; D044466:Asian People; D016022:Case-Control Studies; D000697:Central Nervous System Stimulants / Q000009:adverse effects*; D030541:Databases, Genetic; D006801:Humans; D007564:Japan; D015810:Linkage Disequilibrium; D008297:Male; D008694:Methamphetamine / Q000009:adverse effects*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011605:Psychoses, Substance-Induced / Q000209:etiology / Q000235:genetics*; D056564:Sirtuin 1 / Q000235:genetics*; D055815:Young Adult
chemical_list: D000697:Central Nervous System Stimulants; D008694:Methamphetamine; C447939:SIRT1 protein, human; D056564:Sirtuin 1