title: [Allergic contact dermatitis and atopy].
abstract: Retrospective studies demonstrate that the prevalence of skin sensitization does not significantly differ between atopic and non-atopic patients. In children and adolescents the risk for sensitization seems to occur independently from AD. According to the results of a recent study, AD patients are overrepresented in the group of polysensitized patients. IgE-mediated sensitization as well as an early onset of AD and duration of the disease have been identified as possible risk factors for skin sensitization to contact allergens. A defective permeability barrier with increased epidermal water loss is a hallmark of AD and contributes to sensitization against common allergens. A highly significant association between FLG mutations and the risk of early onset, severe, persistent AD and an increased risk for asthma has been shown in several studies. A more recent study revealed an association between FLG mutations and increased nickel sensitization, but not other contact allergens. However, further large prospective studies with well-characterized patients are necessary to clarify the correlation between impaired skin barrier, atopic dermatitis and allergic contact dermatitis.
authors: Klinik für Dermatologie, Allergologie und Venerologie, Medizinische Hochschule Hannover. niebuhr.margarete@mh-hannover.de
authors: M
authors: M
authors: Niebuhr
authors: A
authors: A
authors: Kapp
authors: T
authors: T
authors: Werfel
authors: A
authors: A
authors: Heratizadeh
mesh_terms: D000293:Adolescent; D000328:Adult; D000369:Aged, 80 and over; D000485:Allergens / Q000276:immunology; D001249:Asthma / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D002648:Child; D004252:DNA Mutational Analysis; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D000091344:Filaggrin Proteins; D006801:Humans; D055261:Immunogenetic Phenomena / Q000235:genetics / Q000276:immunology; D007073:Immunoglobulin E / Q000097:blood; D010328:Patch Tests; D012307:Risk Factors; D012867:Skin / Q000276:immunology
chemical_list: D000485:Allergens; C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007073:Immunoglobulin E