title: New insight into marine alkaloid metabolic pathways: revisiting oroidin biosynthesis.
abstract: Sponge natural product biosynthesis: A highly sensitive in vivo protocol based on (14)C radiolabeled precursors and beta-imager autoradiography allowed the unraveling of the origin of the pyrrole 2-aminoimidazole-containing key biosynthetic intermediate oroidin. Proline and lysine are now proposed as the early precursors of the pyrrole and the 2-aminoimidazole moieties of oroidin respectively.
authors: LCMBA UMR 6001 CNRS, Institut de Chimie de Nice, Université de Nice-Sophia Antipolis, Parc Valrose, 06108 Nice, France.
authors: Grégory
authors: G
authors: Genta-Jouve
authors: Nadja
authors: N
authors: Cachet
authors: Serge
authors: S
authors: Holderith
authors: François
authors: F
authors: Oberhänsli
authors: Jean-Louis
authors: JL
authors: Teyssié
authors: Ross
authors: R
authors: Jeffree
authors: Ali
authors: A
authors: Al Mourabit
authors: Olivier P
authors: OP
authors: Thomas
mesh_terms: D000470:Alkaloids / Q000378:metabolism*; D000818:Animals; D047089:Axinella / Q000378:metabolism*; D007093:Imidazoles / Q000378:metabolism; D008239:Lysine / Q000378:metabolism; D053858:Metabolic Networks and Pathways; D011392:Proline / Q000378:metabolism; D011758:Pyrroles / Q000378:metabolism*
chemical_list: D000470:Alkaloids; D007093:Imidazoles; D011758:Pyrroles; C552324:pyrrole-2-aminoimidazole; D011392:Proline; D008239:Lysine; C077209:oroidin