title: Controlled drug release characteristics and enhanced antibacterial effect of graphene nanosheets containing gentamicin sulfate.
abstract: A novel methanol derived graphene (MDG) and gentamicin sulfate nanohybrid was prepared, and the loading and release behaviour of gentamicin on MDG is investigated. An efficient drug loading of 2.57 mg mg(-1) was obtained at pH 7. By applying release kinetic models, the mechanism of release of the drug from the MDG matrix was found to be following the Korsmeyer-Peppas model. However, the diffusional release exponent (n) value lies below 0.5 demonstrating that the mechanism controlling the drug release is the Fickian diffusion.
authors: Department of Pharmaceutical Science, Faculty of Health, Medical Sciences, Indigenous & Alternative Systems of Medicine, Sam Higginbottom Institute of Agriculture, Technology and Sciences, Allahabad 211007, India. himanshu.nac@gmail.com
authors: Himanshu
authors: H
authors: Pandey
authors: Vyom
authors: V
authors: Parashar
authors: Rashmi
authors: R
authors: Parashar
authors: Rajiv
authors: R
authors: Prakash
authors: Promod W
authors: PW
authors: Ramteke
authors: Avinash C
authors: AC
authors: Pandey
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D005839:Gentamicins / Q000737:chemistry* / Q000494:pharmacology; D006108:Graphite / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D049329:Nanostructures / Q000737:chemistry*; D013818:Thermogravimetry
chemical_list: D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D005839:Gentamicins; D006108:Graphite