title: Antimicrobial susceptibility of Arcanobacterium pyogenes isolated from the lungs of white-tailed deer (Odocoileus virginianus) with pneumonia.
abstract: In vitro susceptibilities of 29 strains of Arcanobacterium pyogenes isolated from lung lesions of white-tailed deer (Odocoileus virginianus) with pneumonia were determined using the broth microdilution method to ascertain efficacious treatment options for pneumonic white-tailed deer. All 29 A. pyogenes strains tested were susceptible to ceftiofur, spectinomycin, tiamulin, and trimethoprim-sulfamethoxazole but were resistant to both danofloxacin and sulfadimethoxine. Likewise, all 29 isolates were either fully susceptible or intermediately susceptible to gentamicin (25 susceptible; 4 intermediate) and tulathromycin (25 susceptible; 4 intermediate). At least one isolate of A. pyogenes tested was resistant to ampicillin, chlortetracycline, clindamycin, enrofloxacin, florfenicol, oxytetracycline, penicillin, and tilmicosin suggesting their ineffectiveness in treating A. pyogenes-associated lung infections in white-tailed deer. Minimum inhibitory concentration (MIC) data for tylosin and neomycin could not be interpreted due to unavailability of Clinical and Laboratory Standards Institute (CLSI)-approved breakpoints for these 2 agents. In summary, based on MIC values, ceftiofur, spectinomycin, tiamulin, and trimethoprim-sulfamethoxazole are more efficacious than other antimicrobial agents for treating A. pyogenes-related pneumonia in white-tailed deer. However, ceftiofur may be preferred over the other 4 drugs as it is being widely used to treat respiratory disease in cattle and other animal species, as well as is available for single dose parenteral administration.
authors: Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA.
authors: Lisa A
authors: LA
authors: Tell
authors: Jason W
authors: JW
authors: Brooks
authors: Valerie
authors: V
authors: Lintner
authors: Tammy
authors: T
authors: Matthews
authors: Subhashinie
authors: S
authors: Kariyawasam
mesh_terms: D000193:Actinomycetales Infections / Q000453:epidemiology / Q000382:microbiology / Q000662:veterinary*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D055667:Arcanobacterium / Q000187:drug effects* / Q000302:isolation & purification*; D003670:Deer; D024881:Drug Resistance, Bacterial; D005260:Female; D008168:Lung / Q000382:microbiology*; D008297:Male; D018410:Pneumonia, Bacterial / Q000453:epidemiology / Q000382:microbiology / Q000662:veterinary*; D014481:United States / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents