title: Anthropogenic and naturally occurring polybrominated phenolic compounds in the blood of cetaceans stranded along Japanese coastal waters.
abstract: We determined the residue levels and patterns of hydroxylated polybrominated diphenyl ethers (OH-PBDEs), and related compounds, such as PBDEs, methoxylated PBDEs (MeO-PBDEs), and bromophenols (BPhs) in the blood of eleven cetacean species stranded along the Japanese coasts. The dominant OH- and MeO-PBDE isomers found in all cetaceans were 6OH-BDE47 and 6MeO-BDE47. Additionally, 2,4,6-triBPh was dominant isomer in all cetaceans. In contrast, specific differences in the distribution of para- and meta- OH-PBDE isomers and some BPhs (potential PBDEs metabolites) were found among the cetaceans. Residue levels of ΣMeO-PBDEs and 6OH-BDE47 + 2'OH-BDE68, and 2,4,6-triBPh and 6OH-BDE47 + 2'OH-BDE68 showed a significant positive correlation. These results may suggest that the large percentages of OH-PBDEs, MeO-PBDEs and 2,4,6-triBPh might share common source (i.e. biosynthesis by marine organisms), or metabolic pathway in cetacean species. Significant correlations were found between the concentrations of BDE99 and 2,4,5-triBPh. This result suggested that 2,4,5-triBPh in cetaceans could be a metabolite of BDE99.
authors: Center for Marine Environmental Studies, Ehime University, Bunkyo-cho 2-5, Matsuyama 790-8577, Japan. keinomi@agr.ehime-u.ac.jp
authors: Kei
authors: K
authors: Nomiyama
authors: Akifumi
authors: A
authors: Eguchi
authors: Hazuki
authors: H
authors: Mizukawa
authors: Mari
authors: M
authors: Ochiai
authors: Satoko
authors: S
authors: Murata
authors: Masayuki
authors: M
authors: Someya
authors: Tomohiko
authors: T
authors: Isobe
authors: Tadasu K
authors: TK
authors: Yamada
authors: Shinsuke
authors: S
authors: Tanabe
mesh_terms: D000818:Animals; D002591:Cetacea / Q000097:blood*; D004784:Environmental Monitoring; D005260:Female; D055768:Halogenated Diphenyl Ethers / Q000097:blood* / Q000737:chemistry; D007536:Isomerism; D007564:Japan; D008297:Male; D012623:Seawater / Q000737:chemistry*; D014874:Water Pollutants, Chemical / Q000097:blood* / Q000737:chemistry; D014877:Water Pollution, Chemical
chemical_list: D055768:Halogenated Diphenyl Ethers; D014874:Water Pollutants, Chemical