title: Leukotriene synthesis inhibitor decreases vasopressin release in the early phase of sepsis.
abstract: The aim was to analyze the effect of leukotriene synthesis inhibitor administered intraperitoneally in vasopressin release during sepsis. Male Wistar rats received injections of MK-886 (1.0, 2.0 or 4.0 mg/kg) or vehicle (DMSO 5%) 1 h before cecal ligation and puncture. There was some variation on the survival rate depending on the dose used but the drug did not modify the hematocrit, osmolality, serum sodium and nitrate, plasma protein, and neutrophil recruitment, in any dose. Nevertheless, vasopressin (AVP) release decreased in a dose-response manner in the early phase of sepsis. These results support the suggestion that leukotrienes (LTs) are involved in AVP release during sepsis.
authors: Departamento de Morfologia, Estomatologia e Fisiologia, Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo, Avenida do Café s/n, CEP 14040-900, Ribeirão Preto, SP, Brazil.
authors: Thalita Freitas
authors: TF
authors: Martins
authors: Carlos Artério
authors: CA
authors: Sorgi
authors: Lúcia Helena
authors: LH
authors: Faccioli
authors: Maria José Alves
authors: MJ
authors: Rocha
mesh_terms: D000818:Animals; D002432:Cecum / Q000601:surgery; D002465:Cell Movement / Q000187:drug effects / Q000502:physiology; D004195:Disease Models, Animal; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D006400:Hematocrit / Q000379:methods; D007211:Indoles / Q000627:therapeutic use*; D015289:Leukotrienes / Q000378:metabolism; D008026:Ligation / Q000379:methods; D016859:Lipoxygenase Inhibitors / Q000633:toxicity; D008297:Male; D009504:Neutrophils / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D009566:Nitrates / Q000097:blood; D009994:Osmolar Concentration; D010529:Peritoneal Cavity / Q000473:pathology; D011506:Proteins / Q000378:metabolism; D011677:Punctures / Q000009:adverse effects; D011863:Radioimmunoassay; D051381:Rats; D017208:Rats, Wistar; D018805:Sepsis / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D012964:Sodium / Q000097:blood; D014667:Vasopressins / Q000378:metabolism*; D002722:Chlorobenzenes
chemical_list: D004791:Enzyme Inhibitors; D007211:Indoles; D015289:Leukotrienes; D016859:Lipoxygenase Inhibitors; D009566:Nitrates; D011506:Proteins; D012964:Sodium; D014667:Vasopressins; C060893:MK-886; D002722:Chlorobenzenes