title: Phospholipase A2 group IIA expression correlates with prolonged survival in gastric cancer.
abstract: OBJECTIVE
  The secreted phospholipase A2 type IIA (PLA2G2A) gene has been identified as a modifier of intestinal adenoma multiplicity in Apc(Min/+) mice. The aim of the present study was to analyse the clinical significance of PLA2G2A expression in human gastric cancer.
  
  
  RESULTS
  Using immunohistochemistry, cytoplasmic immunoreactivity of PLA2G2A was observed in 27% (40 of 149) of gastric cancer tissues compared with negative staining in normal mucosa. The PLA2G2A expression rate in well-differentiated carcinoma was elevated significantly compared with that in poorly differentiated carcinoma (46% versus 19%, P = 0.001). Statistical analysis also revealed that PLA2G2A expression correlated negatively with depth of mural invasion, lymph node metastasis and tumour-node-metastasis (TNM) stage (P < 0.05). Patients with positive PLA2G2A expression showed higher 5-year overall survival than those with negative expression (P = 0.0004). In intestinal metaplasia, PLA2G2A was found to be abundant in Paneth cells. The coexistence of PLA2G2A and lysozyme was observed in Paneth cell-rich gastric cancer (P < 0.0001).
  
  
  CONCLUSIONS
  PLA2G2A may predict survival and might be a potential biomarker for early detection and individualized therapy.
authors: Department of Surgery, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China.
authors: Xiao-Fang
authors: XF
authors: Xing
authors: Hong
authors: H
authors: Li
authors: Xi-Yao
authors: XY
authors: Zhong
authors: Lian-Hai
authors: LH
authors: Zhang
authors: Xiao-Hong
authors: XH
authors: Wang
authors: Yi-Qiang
authors: YQ
authors: Liu
authors: Shu-Qin
authors: SQ
authors: Jia
authors: Tao
authors: T
authors: Shi
authors: Zhao-Jian
authors: ZJ
authors: Niu
authors: Yong
authors: Y
authors: Peng
authors: Hong
authors: H
authors: Du
authors: Gui-Guo
authors: GG
authors: Zhang
authors: Ying
authors: Y
authors: Hu
authors: Ai-Ping
authors: AP
authors: Lu
authors: Ji-You
authors: JY
authors: Li
authors: She
authors: S
authors: Chen
authors: Jia-Fu
authors: JF
authors: Ji
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology* / Q000401:mortality / Q000556:secondary; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D002681:China / Q000453:epidemiology; D005260:Female; D054501:Group II Phospholipases A2 / Q000378:metabolism*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009113:Muramidase / Q000378:metabolism; D009361:Neoplasm Invasiveness; D019879:Paneth Cells / Q000201:enzymology / Q000473:pathology; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D054501:Group II Phospholipases A2; D009113:Muramidase