title: [Stability study of paediatric extemporaneous parenteral nutrition with lipids].
abstract: Stability of extemporaneous parenteral nutrition is a critical aspect of these formulations, with impact in patient safety and quality of service. In lipid emulsions physical stability can be assessed by the increase in the number of lipid globules of size superior than 500 nm, generated by coalescence of small globules during time.
  
  
  OBJECTIVE
  To determine medium size of the lipid globules that compose the internal phase of TNA, in order to evaluate its stability and establish beyond-use date of the parenteral nutrition. To evaluate distribution profile of the lipid globules in the parenteral nutrition and compare it with this of the lipid emulsion used as raw material.
  
  
  METHODS
  Globule size assessment by dynamic light scattering in a paediatric extemporaneous parenteral nutrition formula of frequent use, stored in different periods of time and temperatures.
  
  
  RESULTS
  Medium globule size of the parenteral nutrition analyzed samples did not exceed the limit recommended by literature. Medium size and distribution of the lipid globules in the original lipid emulsion did not have significative changes after the compounding of the parenteral nutrition.
  
  
  CONCLUSIONS
  Obtained data allow to consider that the extemporaneous parenteral nutrition evaluated would have a beyond-use date superior than the one now in use. This research must be deepened by the study of other formulas of parenteral nutrition in order to optimize the setting of beyond-use date.
authors: Laboratorio de Terapia Intravenosa LATIVSA, Rosario, Argentina. federicotuan@hotmail.com
authors: F
authors: F
authors: Tuan
authors: M
authors: M
authors: Montalto
authors: Ma B
authors: MB
authors: Pell
authors: M
authors: M
authors: Bianchi
authors: S
authors: S
authors: Pendica
authors: Ma L
authors: ML
authors: Traverso
mesh_terms: D002648:Child; D004355:Drug Stability; D005217:Fat Emulsions, Intravenous / Q000737:chemistry*; D006801:Humans; D008027:Light; D010288:Parenteral Nutrition / Q000379:methods*; D010316:Particle Size; D012542:Scattering, Radiation; D013696:Temperature; D013997:Time Factors
chemical_list: D005217:Fat Emulsions, Intravenous