title: Polymorphism associated with the Schistosoma mansoni tetraspanin-2 gene.
abstract: A vaccine against schistosomiasis would contribute significantly to reducing the 3-70 million disability-adjusted life years lost annually to the disease. Towards this end, inoculation with the large extracellular loop (EC-2) of Schistosoma mansoni tetraspanin-2 protein (Sm-TSP-2) has proved effective in reducing worm and egg burdens in S. mansoni-infected mice. The EC-2 loop of Schistosoma japonicum TSP-2, however, has been found to be highly polymorphic, perhaps diminishing the likelihood that this antigen can be used for vaccination against this species. Here, we examine polymorphism of the EC-2 of Sm-TSP-2 in genetically unique worms derived from six individuals from Kisumu, Kenya.
authors: Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA.
authors: Pauline M
authors: PM
authors: Cupit
authors: Michelle L
authors: ML
authors: Steinauer
authors: Bradley W
authors: BW
authors: Tonnessen
authors: L
authors: L
authors: Eric Agola
authors: Joseph M
authors: JM
authors: Kinuthia
authors: Ibrahim N
authors: IN
authors: Mwangi
authors: Martin W
authors: MW
authors: Mutuku
authors: Gerald M
authors: GM
authors: Mkoji
authors: Eric S
authors: ES
authors: Loker
authors: Charles
authors: C
authors: Cunningham
mesh_terms: D000483:Alleles; D000818:Animals; D000947:Antigens, Helminth / Q000235:genetics*; D006801:Humans; D007630:Kenya; D008297:Male; D020125:Mutation, Missense; D017354:Point Mutation; D011110:Polymorphism, Genetic; D012550:Schistosoma mansoni / Q000235:genetics*; D059470:Tetraspanins / Q000235:genetics*; D014612:Vaccines / Q000235:genetics / Q000276:immunology
chemical_list: D000947:Antigens, Helminth; D059470:Tetraspanins; D014612:Vaccines