title: [Endothelial injury and erectile dysfunction].
abstract: The endothelium plays an important role in maintaining vascular homeostasis, regulating vascular tone and blood flow, and preserving a non-thrombogenic blood-tissue interface, and the normal function of the vascular endothelium is essential for penile erection. In most cases, erectile dysfunction (ED) is accompanied by endothelial dysfunction, and endothelial injury is a major pathological basis of ED, which can be induced by bad lifestyles, cardiovascular diseases, reactive oxygen species, and inflammatory mediators. The vascular endothelium is capable of self-repairing, and endothelial injury results from the unbalanced factors of injury and repair. This review focuses on the mechanism and repair of endothelial injury and the relationship of endothelial injury with ED.
authors: PLA Research Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China.
authors: Jie-Hua
authors: JH
authors: Ma
authors: Tong-Da
authors: TD
authors: Cheng
authors: Lian-Jun
authors: LJ
authors: Pan
authors: Yu-Feng
authors: YF
authors: Huang
mesh_terms: D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology; D007172:Erectile Dysfunction / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male