title: Mechanistic mammalian target of rapamycin (MTOR) cell signaling: effects of select nutrients and secreted phosphoprotein 1 on development of mammalian conceptuses.
abstract: Morphological differentiation of uterine glands in mammals is a postnatal event vulnerable to adverse effects of endocrine disruptors. Exposure of ewe lambs to a progestin from birth to postnatal day 56 prevents development of uterine glands and, as adults, the ewes are unable to exhibit estrous cycles or maintain pregnancy. Uterine epithelia secrete proteins and transport nutrients into the uterine lumen necessary for conceptus development, pregnancy recognition signaling and implantation, including arginine and secreted phosphoprotein 1 (SPP1). Arginine can be metabolized to nitric oxide and to polyamines or act directly to activate MTOR cell signaling to stimulate proliferation, migration, and mRNA translation in trophectoderm cells. SPP1 binds αvβ3 and α5β1 integrins and induces focal adhesion assembly, adhesion and migration of conceptus trophectoderm cells during implantation. Thus, arginine and SPP1 mediate growth, migration, cytoskeletal remodeling and adhesion of trophectoderm essential for pregnancy recognition signaling and implantation.
authors: Center for Animal Biotechnology and Genomics and Department of Animal Science, Texas A&M University, College Station, TX, USA. fbazer@cvm.tamu.edu
authors: Fuller W
authors: FW
authors: Bazer
authors: Gwonhwa
authors: G
authors: Song
authors: Jinyoung
authors: J
authors: Kim
authors: David W
authors: DW
authors: Erikson
authors: Greg A
authors: GA
authors: Johnson
authors: Robert C
authors: RC
authors: Burghardt
authors: Haijun
authors: H
authors: Gao
authors: M
authors: M
authors: Carey Satterfield
authors: Thomas E
authors: TE
authors: Spencer
authors: Guoyao
authors: G
authors: Wu
mesh_terms: D000818:Animals; D047108:Embryonic Development; D005260:Female; D047109:Fetal Development; D006801:Humans; D007370:Interferon Type I / Q000378:metabolism / Q000502:physiology; D039382:Maternal Nutritional Physiological Phenomena; D053495:Osteopontin / Q000378:metabolism / Q000502:physiology*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism / Q000502:physiology*; D014599:Uterus / Q000254:growth & development / Q000378:metabolism / Q000502:physiology
chemical_list: D007370:Interferon Type I; D011257:Pregnancy Proteins; C020947:interferon tau; D053495:Osteopontin; D058570:TOR Serine-Threonine Kinases