title: Prognostic values of serum IP-10 and IL-17 in patients with pulmonary tuberculosis.
abstract: OBJECTIVE
  To identify patients at high risk of relapse after anti-tuberculosis (TB) therapy or with poor long-term outcomes.
  
  
  METHODS
  Fifty-one patients with pulmonary TB: 7 were classified as high association with both cavitations on initial chest radiography and positive sputum smear/cultures after two months of anti-TB treatment (HA group); 19 medium association (MA, one risk alone); and 25 low association (LA, neither risk). Serum interferon (IFN)-γ-inducible protein 10 (IP-10), interleukin-17 (IL-17), and C-reactive protein levels were investigated.
  
  
  RESULTS
  There was a trend towards higher serum IP-10 levels (p=0.042) for HA patients throughout the 6-month treatment period. Month-2 IP-10 levels were higher in the HA than in the MA/LA group (656.2 ± 234.4 vs. 307.6 ± 258.5 pg/ml, adjusted p =0.005). Receiver operating characteristic curves showed that the risk of relapse was well-captured by month-2 IP-10 levels at a cut-off value of 431 pg/ml (AUC=0.857, 95% CI 0.75-0.97, p =0.003). Month-2 serum IL-17 levels were lower in non-survivors than survivors (15.7 ± 2.9 pg/ml vs. 24.6 ± 8.2 pg/ml, p=0.001). Multivariate analysis demonstrated that a month-2 serum IL-17 level of ⩽ 17 pg/ml (p =0.026) was independently associated with all-cause mortality.
  
  
  CONCLUSIONS
  Serum IP-10 and IL-17 levels after 2 months of anti-TB treatment may be biomarkers for estimating risk of both cavitation and delayed sputum conversion, and for predicting long-term mortality, respectively.
authors: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
authors: Yung-Che
authors: YC
authors: Chen
authors: Chien-Hung
authors: CH
authors: Chin
authors: Shih-Feng
authors: SF
authors: Liu
authors: Chao-Chien
authors: CC
authors: Wu
authors: Chia-Cheng
authors: CC
authors: Tsen
authors: Yi-Hsi
authors: YH
authors: Wang
authors: Tung-Ying
authors: TY
authors: Chao
authors: Chien-Hao
authors: CH
authors: Lie
authors: Chung-Jen
authors: CJ
authors: Chen
authors: Chin-Chou
authors: CC
authors: Wang
authors: Meng-Chih
authors: MC
authors: Lin
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D054357:Chemokine CXCL10 / Q000097:blood*; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014397:Tuberculosis, Pulmonary / Q000097:blood* / Q000188:drug therapy* / Q000401:mortality
chemical_list: D015415:Biomarkers; C114753:CXCL10 protein, human; D054357:Chemokine CXCL10; D020381:Interleukin-17