title: Glycoconjugate expression in adenoid cystic carcinoma of the salivary glands: up-regulation of L1 predicts fatal prognosis.
abstract: OBJECTIVE
  The up-regulation of the cell adhesion molecule L1 has been associated with impaired prognosis in several cancers. This study aimed to identify potential prognostic markers, including L1, in adenoid cystic carcinoma of the salivary glands (ACCs), which might give additional insight into the molecular mechanisms underlying malignant progression.
  
  
  RESULTS
  The expression of L1 was analysed in 34 primary ACCs (nine tubular, 15 cribriform, nine solid, one mixed) and correlated with recurrence, metastasis, overall survival and clinicopathological parameters. Independent of the histological subtype, intense L1 expression in the primary tumours was associated significantly with metastasis (P = 0.02) and death (P = 0.044). In the subgroup of cribriform ACCs, 10 of 15 tumours contained pseudocysts, which were associated with significantly lower recurrence rates (P = 0.003), lower metastasis rates (P = 0.009) and a prolonged overall survival (P =0.004).
  
  
  CONCLUSIONS
  Determination of L1 expression in primary ACCs improves risk estimations. As up-regulation of L1 expression predicts fatal prognosis, L1 might be involved functionally in growth and spread of ACC and might thus present a molecular target for future therapeutic strategies.
authors: Zentrum für Experimentelle Medizin, Institut für Anatomie II: Experimentelle Morphologie, Universitätsklinikum Hamburg Eppendorf, Hamburg, Germany.
authors: Anka
authors: A
authors: Dahl
authors: Janina
authors: J
authors: Teegen
authors: Peter
authors: P
authors: Altevogt
authors: Thomas
authors: T
authors: Löning
authors: Udo
authors: U
authors: Schumacher
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism; D003528:Carcinoma, Adenoid Cystic / Q000378:metabolism / Q000401:mortality / Q000556:secondary*; D015815:Cell Adhesion Molecules / Q000378:metabolism; D005260:Female; D006001:Glycoconjugates / Q000378:metabolism*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D039842:Neural Cell Adhesion Molecule L1 / Q000378:metabolism*; D011379:Prognosis; D012468:Salivary Gland Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D012470:Salivary Glands, Minor / Q000378:metabolism / Q000473:pathology; D015996:Survival Rate; D015854:Up-Regulation
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; C069847:CD66 antigens; D015815:Cell Adhesion Molecules; D006001:Glycoconjugates; D039842:Neural Cell Adhesion Molecule L1