title: The oxidative potential and biological effects induced by PM10 obtained in Mexico City and at a receptor site during the MILAGRO Campaign.
abstract: As part of a field campaign that studied the impact of Mexico City pollution plume at the local, sub-regional and regional levels, we studied transport-related changes in PM(10) composition, oxidative potential and in vitro toxicological patterns (hemolysis, DNA degradation). We collected PM(10) in Mexico City (T(0)) and at a suburban-receptor site (T(1)), pooled according to two observed ventilation patterns (T(0) → T(1) influence and non-influence). T(0) samples contained more Cu, Zn, and carbon whereas; T(1) samples contained more of Al, Si, P, S, and K (p < 0.05). Only SO(4)(-2) increased in T(1) during the influence periods. Oxidative potential correlated with Cu/Zn content (r = 0.74; p < 0.05) but not with biological effects. T(1) PM(10) induced greater hemolysis and T(0) PM(10) induced greater DNA degradation. Influence/non-influence did not affect oxidative potential nor biological effects. Results indicate that ventilation patterns had little effect on intrinsic PM(10) composition and toxicological potential, which suggests a significant involvement of local sources.
authors: Instituto Nacional de Cancerología, Mexico City, Mexico.
authors: Raul
authors: R
authors: Quintana
authors: Jesús
authors: J
authors: Serrano
authors: Virginia
authors: V
authors: Gómez
authors: Benjamin
authors: B
authors: de Foy
authors: Javier
authors: J
authors: Miranda
authors: Claudia
authors: C
authors: Garcia-Cuellar
authors: Elizabeth
authors: E
authors: Vega
authors: Inés
authors: I
authors: Vázquez-López
authors: Luisa T
authors: LT
authors: Molina
authors: Natalia
authors: N
authors: Manzano-León
authors: Irma
authors: I
authors: Rosas
authors: Alvaro R
authors: AR
authors: Osornio-Vargas
mesh_terms: D016475:3T3 Cells; D000393:Air Pollutants / Q000737:chemistry* / Q000633:toxicity*; D000397:Air Pollution; D000818:Animals; D002947:Cities; D004249:DNA Damage / Q000187:drug effects; D004784:Environmental Monitoring; D004912:Erythrocytes / Q000187:drug effects; D006293:Health Promotion; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D008800:Mexico; D051379:Mice; D010084:Oxidation-Reduction; D010316:Particle Size; D052638:Particulate Matter / Q000737:chemistry* / Q000633:toxicity*
chemical_list: D000393:Air Pollutants; D052638:Particulate Matter