title: In vitro and in vivo investigation of drug-eluting implants for the treatment of periodontal disease.
abstract: This paper developed solvent-free drug-eluting implants for metronidazole delivery for the treatment of periodontal disease and investigated the characteristics of the drug's release from the implants, both in vitro and in vivo, using an HPLC assay. The metronidazole exhibited a two-stage release behavior in vitro with an initial burst release followed by a diffusion-controlled release and then a secondary burst release. The accumulated drug release reached 100% on the 18th day, and the drug-eluting implant was totally dissolved on the same day. Additionally, the drug-eluting disks were implanted within the sub-gingival space of both lower incisors of six rabbits. The curve of in vivo drug release was smoother and showed a predominantly diffusion-controlled release. The implants were totally dissolved at 2 weeks after implantation. The concentration of metronidazole remained above the MIC(90) during the entire investigation.
authors: Department of Periodontics, Division of Dentistry, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
authors: Fu-Ying
authors: FY
authors: Lee
authors: Dave W
authors: DW
authors: Chen
authors: Chih-Chien
authors: CC
authors: Hu
authors: Yu-Te
authors: YT
authors: Hsieh
authors: Shih-Jung
authors: SJ
authors: Liu
authors: Err-Cheng
authors: EC
authors: Chan
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D020099:Coated Materials, Biocompatible; D004058:Diffusion; D004337:Drug Carriers; D004339:Drug Compounding; D019344:Lactic Acid / Q000737:chemistry*; D008795:Metronidazole / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D008826:Microbial Sensitivity Tests; D010510:Periodontal Diseases / Q000188:drug therapy*; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011474:Prosthesis Design; D011817:Rabbits; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D000890:Anti-Infective Agents; D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D008795:Metronidazole; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid