title: Nasal tumor with widespread cutaneous metastases in a Golden Retriever.
abstract: An intact, 8-year-old, male Golden Retriever dog was presented for evaluation of a nasal mass and approximately 30 firm, raised, variably ulcerated dermal and subcutaneous masses. Histopathology of both nasal and multiple skin masses revealed multiple nonencapsulated, infiltrative masses comprising clusters, anastomosing trabeculae, and packets of neoplastic, round to ovoid, hyperchromatic cells with marked nuclear molding. Surrounding the neoplastic cells was a marked stromal response in which many of the spindle-shaped cells expressed muscle-specific actin and had ultrastructural features consistent with myofibroblasts. A literature search indicates that this is the first report in a peer-reviewed journal of cutaneous metastasis of a nasal neuroendocrine tumor in any domestic animal species.
authors: Auburn University College of Veterinary Medicine, Department of Pathobiology, Auburn, Alabama, USA. jaw0007@auburn.edu
authors: J W
authors: JW
authors: Koehler
authors: R C
authors: RC
authors: Weiss
authors: O A
authors: OA
authors: Aubry
authors: A N
authors: AN
authors: Smith
authors: J T
authors: JT
authors: Hathcock
authors: W R
authors: WR
authors: Brawner
mesh_terms: D000818:Animals; D018278:Carcinoma, Neuroendocrine / Q000473:pathology / Q000556:secondary / Q000662:veterinary*; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D046529:Microscopy, Electron, Transmission / Q000662:veterinary; D009669:Nose Neoplasms / Q000473:pathology / Q000662:veterinary*; D012867:Skin / Q000473:pathology* / Q000648:ultrastructure; D012878:Skin Neoplasms / Q000473:pathology / Q000556:secondary / Q000662:veterinary*