title: Net benefits: a multicountry analysis of observational data examining associations between insecticide-treated mosquito nets and health outcomes.
abstract: BACKGROUND
  Several sub-Saharan African countries have rapidly scaled up the number of households that own insecticide-treated mosquito nets (ITNs). Although the efficacy of ITNs in trials has been shown, evidence on their impact under routine conditions is limited to a few countries and the extent to which the scale-up of ITNs has improved population health remains uncertain.
  
  
  RESULTS
  We used matched logistic regression to assess the individual-level association between household ITN ownership or use in children under 5 years of age and the prevalence of parasitemia among children using six malaria indicator surveys (MIS) and one demographic and health survey. We used Cox proportional hazards models to assess the relationship between ITN household ownership and child mortality using 29 demographic and health surveys. The pooled relative reduction in parasitemia prevalence from random effects meta-analysis associated with household ownership of at least one ITN was 20% (95% confidence interval [CI] 3%-35%; I² = 73.5%, p<0.01 for I² value). Sleeping under an ITN was associated with a pooled relative reduction in parasitemia prevalence in children of 24% (95% CI 1%-42%; I² = 79.5%, p<0.001 for I² value). Ownership of at least one ITN was associated with a pooled relative reduction in mortality between 1 month and 5 years of age of 23% (95% CI 13-31%; I² = 25.6%, p>0.05 for I² value).
  
  
  CONCLUSIONS
  Our findings across a number of sub-Saharan African countries were highly consistent with results from previous clinical trials. These findings suggest that the recent scale-up in ITN coverage has likely been accompanied by significant reductions in child mortality and that additional health gains could be achieved with further increases in ITN coverage in populations at risk of malaria. Please see later in the article for the Editors' Summary.
authors: Institute for Health Metrics and Evaluation, University of Washington, Seattle, Washington, United States of America. stevelim@u.washington.edu
authors: Stephen S
authors: SS
authors: Lim
authors: Nancy
authors: N
authors: Fullman
authors: Andrew
authors: A
authors: Stokes
authors: Nirmala
authors: N
authors: Ravishankar
authors: Felix
authors: F
authors: Masiye
authors: Christopher J L
authors: CJ
authors: Murray
authors: Emmanuela
authors: E
authors: Gakidou
mesh_terms: D017954:Africa South of the Sahara / Q000453:epidemiology; D002648:Child; D046688:Child Mortality; D002675:Child, Preschool; D005191:Family Characteristics; D006306:Health Surveys; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D057148:Insecticide-Treated Bednets / Q000706:statistics & numerical data*; D038622:Internationality; D016015:Logistic Models; D008288:Malaria / Q000453:epidemiology / Q000469:parasitology / Q000635:transmission; D017063:Outcome Assessment, Health Care; D010067:Ownership; D018512:Parasitemia / Q000453:epidemiology; D015995:Prevalence