title: Major histocompatibility complex class I-restricted cytotoxic T lymphocyte responses during primary simian immunodeficiency virus infection in Burmese rhesus macaques.
abstract: Major histocompatibility complex class I (MHC-I)-restricted CD8(+)  cytotoxic T lymphocyte (CTL) responses are crucial for the control of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replication. In particular, Gag-specific CTL responses have been shown to exert strong suppressive pressure on HIV/SIV replication. Additionally, association of Vif-specific CTL frequencies with in vitro anti-SIV efficacy has been suggested recently. Host MHC-I genotypes could affect the immunodominance patterns of these potent CTL responses. Here, Gag- and Vif-specific CTL responses during primary SIVmac239 infection were examined in three groups of Burmese rhesus macaques, each group having a different MHC-I haplotype. The first group of four macaques, which possessed the MHC-I haplotype 90-010-Ie, did not show Gag- or Vif-specific CTL responses. However, Nef-specific CTL responses were elicited, suggesting that primary SIV infection does not induce predominant CTL responses specific for Gag/Vif epitopes restricted by 90-010-Ie-derived MHC-I molecules. In contrast, Gag- and Vif-specific CTL responses were induced in the second group of two 89-075-Iw-positive animals and the third group of two 91-010-Is-positive animals. Considering the potential of prophylactic vaccination to affect CTL immunodominance post-viral exposure, these groups of macaques would be useful for evaluation of vaccine antigen-specific CTL efficacy against SIV infection.
authors: Division for AIDS Vaccine Development, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
authors: Midori
authors: M
authors: Nakamura
authors: Yusuke
authors: Y
authors: Takahara
authors: Hiroshi
authors: H
authors: Ishii
authors: Hiromi
authors: H
authors: Sakawaki
authors: Mariko
authors: M
authors: Horiike
authors: Tomoyuki
authors: T
authors: Miura
authors: Tatsuhiko
authors: T
authors: Igarashi
authors: Taeko K
authors: TK
authors: Naruse
authors: Akinori
authors: A
authors: Kimura
authors: Tetsuro
authors: T
authors: Matano
authors: Saori
authors: S
authors: Matsuoka
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D015683:Gene Products, gag / Q000276:immunology; D016346:Gene Products, vif / Q000276:immunology; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*; D008253:Macaca mulatta; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
chemical_list: D015683:Gene Products, gag; D016346:Gene Products, vif; D015395:Histocompatibility Antigens Class I