title: Matricellular proteins: new molecular targets to prevent heart failure.
abstract: Matricellular proteins are highly expressed in reparative responses to pressure and volume overload, ischemia, oxidative stress after myocardial injury, and modulate the inflammatory and fibrotic process in ventricular remodeling, which leads to cardiac dysfunction and eventually overt heart failure. Generally, matricellular proteins loosen strong adhesion of cardiomyocytes to extracellular matrix, which would help cells to move for rearrangement and allow inflammatory cells and capillary vessels to spread during tissue remodeling. Among matricellular proteins, osteopontin (OPN) and tenascin-C (TN-C) are de-adhesion proteins and upregulate the expression and activity of matrix metalloproteinases. These matricellular proteins could be key molecules to diagnose cardiac remodeling and also might be targets for the prevention of adverse ventricular remodeling. This review provides an overview of the role of matricellular proteins such as OPN and TN-C in cardiac function and remodeling, as determined by both in basic and in clinical studies.
authors: Department of Cardiovascular Medicine, Hokkaido Medical Center, Sapporo, Japan. okamotoh@ med.hokudai.ac.jp
authors: Hiroshi
authors: H
authors: Okamoto
authors: Kyoko
authors: K
authors: Imanaka-Yoshida
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D055511:CCN Intercellular Signaling Proteins / Q000378:metabolism; D002448:Cell Adhesion; D016326:Extracellular Matrix Proteins / Q000235:genetics / Q000378:metabolism*; D006331:Heart Diseases / Q000150:complications / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D006333:Heart Failure / Q000209:etiology / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D053495:Osteopontin / Q000378:metabolism; D011237:Predictive Value of Tests; D011379:Prognosis; D015398:Signal Transduction; D019063:Tenascin / Q000378:metabolism; D020257:Ventricular Remodeling
chemical_list: D015415:Biomarkers; D055511:CCN Intercellular Signaling Proteins; D016326:Extracellular Matrix Proteins; D019063:Tenascin; D053495:Osteopontin