title: A comparison of clinicopathological features and molecular markers in british and nigerian women with breast cancer.
abstract: BACKGROUND
  Some studies have suggested that breast cancer in black women is more aggressive than in white women. This study's aim was to look for evidence of differences in tumour biology between the two cohorts.
  
  
  METHODS
  This study compared the stage, grade and pathological expression of five immunohistochemical markers (oestrogen receptor [ER], progesterone receptor [PR], ERBB2, P53 and cyclin D1 [CCND1]) in tumour biopsies from age-matched cohorts of patients from Nigeria and England. Sixty-eight suitable samples from Nigerian (n = 34) and British (n = 34) breast cancer patients were retrieved from histology tissue banks.
  
  
  RESULTS
  There were significant differences between the two cohorts in the expression of ER and CCND1; and stark differences in the clinical stage at presentation. But no significant differences were observed for tumour grade.
  
  
  CONCLUSIONS
  There was a significantly, low ER expression in the Nigerian cases which also predicts a poor response to hormonal therapy as well as a poorer prognosis. Differences in clinical stage at presentation will most likely influence prognosis between Nigerian and British women with breast cancer.
authors: School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, NR47TJ, U.K.
authors: Isaac D
authors: ID
authors: Gukas
authors: Anne C
authors: AC
authors: Girling
authors: Barnabas M
authors: BM
authors: Mandong
authors: Wendy
authors: W
authors: Prime
authors: Barbara A
authors: BA
authors: Jennings
authors: Samuel J
authors: SJ
authors: Leinster