title: Evaluation of trabecular bone formation in a canine model surrounding a dental implant fixture immobilized with an antimicrobial peptide derived from histatin.
abstract: JH8194 induces osteoblast differentiation, although it was originally designed to improve antifungal activity. This suggests that JH8194 is useful for implant treatment. Therefore, the aim of this study was to evaluate the osseointegration capacity of JH8194-modified titanium dental implant fixtures (JH8194-Fi). The implants were randomly implanted into the edentulous ridge of dog mandibles. Healing abutments were inserted immediately after implant placement. Three weeks later, peri-implant bone levels, the first bone-to-implant contact points, and trabecular bone formation surrounding the implants were assessed by histological and digital image analyses based on microcomputed tomography (microCT). The histological analysis revealed an enhancement of mature trabecular bone around the JH8194-Fi compared with untreated fixtures (control-Fi). Similarly, microCT combined with analysis by Zed View™ also showed increased trabecular bone formation surrounding the JH8194-Fi compared with the control-Fi (Student's t-test, P < 0.05). JH8194 may offer an alternative biological modification of titanium surfaces to enhance trabecular bone formation around dental implants, which may contribute to the transient acquirement of osseointegration and the long-term success of implant therapy.
authors: Department of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan. makihira@dent.kyushu-u.ac.jp
authors: Seicho
authors: S
authors: Makihira
authors: Hiroki
authors: H
authors: Nikawa
authors: Takahiro
authors: T
authors: Shuto
authors: Masahiro
authors: M
authors: Nishimura
authors: Yuichi
authors: Y
authors: Mine
authors: Koichiro
authors: K
authors: Tsuji
authors: Keishi
authors: K
authors: Okamoto
authors: Yuhiro
authors: Y
authors: Sakai
authors: Masanori
authors: M
authors: Sakai
authors: Naoya
authors: N
authors: Imari
authors: Satoshi
authors: S
authors: Iwata
authors: Mika
authors: M
authors: Takeda
authors: Fumio
authors: F
authors: Suehiro
mesh_terms: D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000008:administration & dosage*; D001842:Bone and Bones / Q000473:pathology / Q000502:physiology*; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D004285:Dogs; D054808:Histatins / Q000008:administration & dosage* / Q000737:chemistry; D008334:Mandible / Q000473:pathology; D016348:Osseointegration; D010006:Osteoblasts / Q000166:cytology; D019736:Prostheses and Implants; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*; D014057:Tomography, X-Ray Computed; D055114:X-Ray Microtomography
chemical_list: D023181:Antimicrobial Cationic Peptides; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D054808:Histatins; D014025:Titanium