title: Evidence that purifying selection acts on promoter sequences.
abstract: We tested whether functionally important sites in bacterial, yeast, and animal promoters are more conserved than their neighbors. We found that substitutions are predominantly seen in less important sites and that those that occurred tended to have less impact on gene expression than possible alternatives. These results suggest that purifying selection operates on promoter sequences.
authors: Department of Ecology and Evolution, Committee on Genetics, Genomics and Systems Biology, Institute for Genomics and Systems Biology, University of Chicago, Chicago, Illinois 60637, USA.
authors: Robert K
authors: RK
authors: Arthur
authors: Ilya
authors: I
authors: Ruvinsky
mesh_terms: D000818:Animals; D001419:Bacteria / Q000235:genetics; D019295:Computational Biology; D017124:Conserved Sequence; D019143:Evolution, Molecular; D009154:Mutation; D009711:Nucleotides / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012641:Selection, Genetic; D015003:Yeasts / Q000235:genetics
chemical_list: D009711:Nucleotides