title: Interleukin-8 derived from local tissue-resident stromal cells promotes tumor cell invasion.
abstract: The aim of this study is to evaluate the role of adipose tissue resident stromal cells on tumor cell invasion. Our data show that a subpopulation of adipose tissue derived stromal cells expressing Nestin, NG2, α-smooth muscle actin and PDGFR-α migrate toward the cancer cells. Microarray analysis revealed the upregulation of IL-8 in the migrated cells. We demonstrated that stromal cell derived IL-8 promote the invasion and the anchorage-independent growth of cancer cells. We conclude that human breast cancer cells attract a subpopulation of stromal cells that secrete IL-8 to promote tumor cell invasion in a paracrine fashion.
authors: Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
authors: Gabriel
authors: G
authors: Welte
authors: Eckhard
authors: E
authors: Alt
authors: Eswaran
authors: E
authors: Devarajan
authors: Srinivasalu
authors: S
authors: Krishnappa
authors: Constantin
authors: C
authors: Jotzu
authors: Yao-Hua
authors: YH
authors: Song
mesh_terms: D000273:Adipose Tissue / Q000166:cytology* / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D001943:Breast Neoplasms / Q000276:immunology* / Q000473:pathology; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D002478:Cells, Cultured; D018920:Coculture Techniques; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000235:genetics / Q000276:immunology*; D009361:Neoplasm Invasiveness / Q000276:immunology* / Q000473:pathology; D020411:Oligonucleotide Array Sequence Analysis; D017154:Stromal Cells / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D059016:Tumor Microenvironment; D015854:Up-Regulation
chemical_list: D016209:Interleukin-8