title: Early syphilis in a man with a negative Treponema pallidum enzyme immunoassay-IgM.
abstract: Most serological tests for syphilis rely on an individual's ability to produce antibodies. A single screening test may be unreliable for screening in those with primary immunodeficiency. We present the first reported case of primary and secondary syphilis with negative Treponema pallidum enzyme immunoassay-IgM and Venereal Disease Research Laboratory tests in a man with common variable immunodeficiency.
authors: Department of Genitourinary Medicine, Royal Victoria Hospital, Belfast, UK. ej_mccarty@hotmail.com
authors: E J
authors: EJ
authors: McCarty
authors: H
authors: H
authors: Keane
authors: K
authors: K
authors: Quinn
authors: W W
authors: WW
authors: Dinsmore
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D017074:Common Variable Immunodeficiency / Q000150:complications*; D006801:Humans; D007124:Immunoenzyme Techniques / Q000379:methods*; D007075:Immunoglobulin M / Q000097:blood*; D008297:Male; D013587:Syphilis / Q000175:diagnosis / Q000503:physiopathology*; D013588:Syphilis Serodiagnosis; D014210:Treponema pallidum / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D007075:Immunoglobulin M