title: [Research properties of the exogenous recombinant human heat shock protein HSP70 on test rodents].
abstract: Our research with Sprague-Dawley rats demonstrates protective properties of recombinant human heat shock protein 70 kDa (exogenous rhHSP70) as a prevent therapy agent for gram-positive sepsis. In this study we investigate acute toxicity of rhHSP70 on CD-1 mice and demonstrate very low dangerous of the substance.
authors: V F
authors: VF
authors: Ostrov
authors: M B
authors: MB
authors: Evgen'ev
authors: A N
authors: AN
authors: Murashev
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D018840:HSP70 Heat-Shock Proteins / Q000627:therapeutic use*; D006801:Humans; D008070:Lipopolysaccharides / Q000276:immunology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins / Q000627:therapeutic use*; D018805:Sepsis / Q000517:prevention & control*; D013211:Staphylococcus aureus / Q000276:immunology; D013682:Teichoic Acids / Q000276:immunology
chemical_list: D018840:HSP70 Heat-Shock Proteins; D008070:Lipopolysaccharides; D011994:Recombinant Proteins; D013682:Teichoic Acids; C009900:lipoteichoic acid