title: [Human amniotic membrane in the management of chronic venous leg ulcers].
abstract: BACKGROUND
  The aim of our paper is to examine changes in the use of human amniotic membrane for venous leg ulcers through clinical studies and to present different models of tissue engineering employing human amniotic membrane for the purpose of future therapeutic use in wound healing.
  
  
  METHODS
  This review is based on information obtained from a PubMed search using the following keywords "Amnion"[Mesh] AND "Leg Ulcer"[Mesh]; "Amnion"[Mesh] AND "Dermatology"[Mesh]. The selected articles are in English or French and deal with the sole use of human amniotic membrane in venous leg ulcers alone.
  
  
  RESULTS
  Human amniotic membrane has a positive impact on chronic venous leg ulcers by promoting granulation tissue formation, reducing fibrosis and inducing re-epithelialisation. Nevertheless, further randomized clinical studies are needed. At the same time, tissue engineering models using human amniotic membrane may help to reduce wound healing time, thereby creating renewed interest in the use of human amniotic membrane.
  
  
  CONCLUSIONS
  Considering its properties and the clinical studies analysed, human amniotic membrane could be useful in venous leg ulcer care.
authors: UMR 645, IFR 133, faculté de médecine, 19, rue Ambroise-Paré, 25000 Besançon, France.
authors: H
authors: H
authors: Tauzin
authors: P
authors: P
authors: Humbert
authors: C
authors: C
authors: Viennet
authors: P
authors: P
authors: Saas
authors: P
authors: P
authors: Muret
mesh_terms: D000650:Amnion; D001684:Biological Dressings / Q000639:trends; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D015331:Cohort Studies; D005544:Forecasting; D006097:Granulation Tissue / Q000502:physiology; D006801:Humans; D007871:Leg Ulcer / Q000628:therapy*; D012189:Retrospective Studies; D023822:Tissue Engineering / Q000639:trends; D014021:Tissue Preservation / Q000379:methods; D014945:Wound Healing