title: The role of p23, Hop, immunophilins, and other co-chaperones in regulating Hsp90 function.
abstract: Molecular chaperones are a diverse group of highly conserved proteins that transiently interact with partially folded polypeptide chains during normal cellular processes, such as protein translation, translocation, and disassembly of protein complexes (1). Prior to folding or after denaturation, hydrophobic residues that are normally sequestered within a folded protein are exposed to the aqueous environment and are prone to aggregation or misfolding. Multiple classes of molecular chaperones, such as Hsp70s and Hsp40s, recognize and transiently bind polypeptides with exposed hydrophobic stretches in order to prevent misfolding. Other types of chaperones, such as Hsp90, have more specialized functions in that they appear to interact with only a subset of cellular proteins. This chapter focuses on the role of Hsp90 and partner co-chaperones in promoting the folding and activation of a diverse group of proteins with critical roles in cellular signaling and function.
authors: Department of Biological Sciences, University of Texas at El Paso, El Paso, TX, USA.
authors: Marc B
authors: MB
authors: Cox
authors: Jill L
authors: JL
authors: Johnson
mesh_terms: D000818:Animals; D018841:HSP90 Heat-Shock Proteins / Q000737:chemistry / Q000378:metabolism*; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D020104:Immunophilins / Q000235:genetics / Q000378:metabolism; D019746:Intramolecular Oxidoreductases / Q000235:genetics / Q000378:metabolism; D051379:Mice; D018832:Molecular Chaperones / Q000235:genetics / Q000378:metabolism*; D000071876:Prostaglandin-E Synthases; D017510:Protein Folding; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D018841:HSP90 Heat-Shock Proteins; D018398:Homeodomain Proteins; C466740:Hop protein, mouse; D018832:Molecular Chaperones; D029701:Saccharomyces cerevisiae Proteins; D020104:Immunophilins; D019746:Intramolecular Oxidoreductases; D000071876:Prostaglandin-E Synthases