title: 15 years of antibiotic stewardship policy in the Nancy Teaching Hospital.
abstract: OBJECTIVE
  The authors report the results of a 15-year antibiotic stewardship policy in the Nancy Teaching Hospital and assess the impact of reinforcing this policy on antibiotic consumption.
  
  
  METHODS
  Antibiotic stewardship policy was initiated in the mid 90s and then reinforced from 2006 onwards. It was completed by prescription guidelines, nominative prescription of antibiotics, and an operational infectious diseases team (OIDT). The objectives were to promote antibiotic stewardship and decrease the use of extended broad spectrum or costly molecules and intravenous administration. Antibiotics consumption, as defined daily dose per 1000 patient days (DDD/1000PD) and in euros, was monitored from 2005 onwards.
  
  
  RESULTS
  Between 2005 and 2008, overall yearly cost of antibiotics dropped by 34% (-€1,308,902) and consumption in DDD/1000PD by 10%. This drop in consumption concerned all antibiotic classes. Teicoplanin prescription dropped by more than 50% and use of fluoroquinolone IV decreased by 15% in 3years. The operational team's interventions were effective since nearly 80% of suggested prescription amendments were accepted by prescribers.
  
  
  CONCLUSIONS
  This experiment shows that it is possible to implement antibiotic stewardship policy. Our results prove a significant decrease in overall consumption of antibiotic, a change in prescribing patterns, with a shift towards the use of cheaper antibiotics.
authors: Service des maladies infectieuses et tropicales, CHU Nancy, hôpitaux de Brabois, bâtiment P. Canton, rue du Morvan, Vandœuvre-Lès-Nancy, Nancy, France. s.bevilacqua@chu-nancy.fr
authors: S
authors: S
authors: Bevilacqua
authors: B
authors: B
authors: Demoré
authors: E
authors: E
authors: Boschetti
authors: T
authors: T
authors: Doco-Lecompte
authors: I
authors: I
authors: May
authors: T
authors: T
authors: May
authors: C
authors: C
authors: Rabaud
authors: N
authors: N
authors: Thilly
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004363:Drug Utilization / Q000592:standards; D004335:Drug and Narcotic Control; D005602:France; D006784:Hospitals, Teaching; D006801:Humans; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents