title: An anisotropic microsphere-based approach for fiber orientation adaptation in soft tissue.
abstract: Evolutionary processes in biological tissue, such as adaptation or remodeling, represent an enterprising area of research. In this paper, we present a multiscale model for the remodeling of fibered structures, such as bundles of collagen fibrils. With this aim, we introduce a von Mises statistical distribution function to account for the directional dispersion of the fibrils, and we remodel the underlying fibrils by changing their orientation. To numerically compute this process, we make use of the microsphere approach, which provides a useful multiscale tool for homogenizing the microstructure behavior, related to the fibrils of the bundle, in the macroscale of the problem. The results show how the fibrils respond to the stimulus by reorientation of their structure. This process leads to a stiffer material eventually reaching a stationary state. These results are in agreement with those reported in the literature, and they characterize the adaptation of biological tissue to external stimuli.
authors: Group of Structural Mechanics and Materials Modeling, Aragón Institute of Engineering Research (I3A), Universidad de Zaragoza, Zaragoza 50010, Spain. psaez@unizar.es
authors: Pablo
authors: P
authors: Sáez
authors: Estefanía
authors: E
authors: Peña
authors: Manuel
authors: M
authors: Doblaré
authors: Miguel Ángel
authors: MÁ
authors: Martínez
mesh_terms: D016880:Anisotropy; D001696:Biomechanical Phenomena; D003094:Collagen / Q000737:chemistry* / Q000648:ultrastructure; D004548:Elasticity; D008863:Microspheres; D008954:Models, Biological
chemical_list: D003094:Collagen