title: Coupling mitochondrial and cell division.
abstract: The mitochondrial network fragments during mitosis to allow proper segregation of the organelles between daughter cells. Two mitotic kinases, the cyclin B-CDK1 complex and Aurora A, are now shown to cooperate with the small G protein RALA and its effector RALBP1 to promote DRP1 phosphorylation and mitochondrial fission.
authors: Koji
authors: K
authors: Yamano
authors: Richard J
authors: RJ
authors: Youle
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D020690:GTPase-Activating Proteins / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D008938:Mitosis; D020725:ral GTP-Binding Proteins / Q000378:metabolism*
chemical_list: D018528:ATP-Binding Cassette Transporters; D020690:GTPase-Activating Proteins; C095637:RALBP1 protein, human; C492198:RALA protein, human; D020725:ral GTP-Binding Proteins