title: Role of p53 gene polymorphism and bladder cancer predisposition in northern India.
abstract: p53 is a major orchestrator of cellular response to a broad array of stress types by regulating apoptosis, cell cycle arrest, etc. A few polymorphic sites, one at codon72 of exon4, intron3 16bpdel/ins, intron6G>A have been studied with regard to Bladder cancer (BC) risk in North Indians. Genotypes were assessed in hospital-based case-control study comprising of 200BC cases, 265healthy controls. After extraction of genomic DNA from blood, genotyping was done using PCR Restriction Fragment Length Polymorphism. Individuals with p53R72P G>C, CC genotype demonstrated marginally reduced risk of BC (p=0.053, OR=0.29, 95% 16bp-ins/del.
authors: Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Uttar Pradesh, India.
authors: Priyanka
authors: P
authors: Srivastava
authors: Praveen K
authors: PK
authors: Jaiswal
authors: Vibha
authors: V
authors: Singh
authors: Rama D
authors: RD
authors: Mittal
mesh_terms: D001500:BCG Vaccine / Q000627:therapeutic use; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D007167:Immunotherapy; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012907:Smoking / Q000235:genetics; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000628:therapy
chemical_list: D001500:BCG Vaccine