title: Volumetric feedback ablation of uterine fibroids using magnetic resonance-guided high intensity focused ultrasound therapy.
abstract: OBJECTIVE
  The purpose of this prospective multicenter study was to assess the safety and technical feasibility of volumetric Magnetic Resonance-guided High Intensity Focused Ultrasound (MR-HIFU) ablation for treatment of patients with symptomatic uterine fibroids.
  
  
  METHODS
  Thirty-three patients with 36 fibroids were treated with volumetric MR-HIFU ablation. Treatment capability and technical feasibility were assessed by comparison of the Non-Perfused Volumes (NPVs) with MR thermal dose predicted treatment volumes. Safety was determined by evaluation of complications or adverse events and unintended lesions. Secondary endpoints were pain and discomfort scores, recovery time and length of hospital stay.
  
  
  RESULTS
  The mean NPV calculated as a percentage of the total fibroid volume was 21.7%. Correlation between the predicted treatment volumes and NPVs was found to be very strong, with a correlation coefficient r of 0.87. All patients tolerated the treatment well and were treated on an outpatient basis. No serious adverse events were reported and recovery time to normal activities was 2.3 ± 1.8 days.
  
  
  CONCLUSIONS
  This prospective multicenter study proved that volumetric MR-HIFU is safe and technically feasible for the treatment of symptomatic uterine fibroids.
  
  
  CONCLUSIONS
  • Magnetic-resonance-guided high intensity focused ultrasound allows non-invasive treatment of uterine fibroids. • Volumetric feedback ablation is a novel technology that allows larger treatment volumes • MR-guided ultrasound ablation of uterine fibroids appears safe using volumetric feedback.
authors: Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 GX, Utrecht, The Netherlands.
authors: M J
authors: MJ
authors: Voogt
authors: H
authors: H
authors: Trillaud
authors: Y S
authors: YS
authors: Kim
authors: W P Th M
authors: WP
authors: Mali
authors: J
authors: J
authors: Barkhausen
authors: L W
authors: LW
authors: Bartels
authors: R
authors: R
authors: Deckers
authors: N
authors: N
authors: Frulio
authors: H
authors: H
authors: Rhim
authors: H K
authors: HK
authors: Lim
authors: T
authors: T
authors: Eckey
authors: H J
authors: HJ
authors: Nieminen
authors: C
authors: C
authors: Mougenot
authors: B
authors: B
authors: Keserci
authors: J
authors: J
authors: Soini
authors: T
authors: T
authors: Vaara
authors: M O
authors: MO
authors: Köhler
authors: S
authors: S
authors: Sokka
authors: Maurice A A J
authors: MA
authors: van den Bosch
mesh_terms: D000293:Adolescent; D000328:Adult; D004867:Equipment Design; D005060:Europe; D005260:Female; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D006801:Humans; D007889:Leiomyoma / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy*; D007902:Length of Stay; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053783:Magnetic Resonance Imaging, Interventional / Q000379:methods*; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors; D014464:Ultrasonic Therapy / Q000379:methods*; D014465:Ultrasonics; D014463:Ultrasonography; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy*