title: Effects of parenteral amoxicillin on recovery rates and new infection rates for contagious ovine digital dermatitis in sheep.
abstract: The present study is a randomised split-flock treatment trial, which compared the effect of foot bathing in a 1 per cent solution of chlortetracycline alone with a treatment protocol that added a single injection of a long-acting amoxicillin. Overall, the prevalence of contagious ovine digital dermatitis in the examined flock was 22 per cent, while 45.7 per cent of affected sheep had infections in two or more feet. Parenteral antibiotic treatment increased the odds of a recovery by 3.8 times (95 per cent confidence interval 1.05 to 14.0) (P=0.008). Moreover, the amoxicillin injection may also have had a preventative effect, reducing the rate of establishment of new infections from 2.5 per cent for foot bathing alone compared with 1.0 per cent with the addition of parenteral amoxicillin.
authors: School of Veterinary Science, University of Liverpool, Leahurst Campus, Neston, Wirral, Cheshire CH64 7TE, UK. jsduncan@liverpool.ac.uk
authors: J S
authors: JS
authors: Duncan
authors: D
authors: D
authors: Grove-White
authors: J W H
authors: JW
authors: Oultram
authors: C J
authors: CJ
authors: Phythian
authors: J V
authors: JV
authors: Dijk
authors: S D
authors: SD
authors: Carter
authors: P J
authors: PJ
authors: Cripps
authors: H J
authors: HJ
authors: Williams
mesh_terms: D000658:Amoxicillin / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001494:Baths / Q000662:veterinary; D058066:Digital Dermatitis / Q000188:drug therapy* / Q000453:epidemiology / Q000517:prevention & control; D005260:Female; D006724:Hoof and Claw / Q000473:pathology; D007263:Infusions, Parenteral / Q000662:veterinary; D008297:Male; D015995:Prevalence; D012008:Recurrence; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy* / Q000453:epidemiology / Q000517:prevention & control; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000658:Amoxicillin