title: Fabrication of doxorubicin functionalized gold nanorod probes for combined cancer imaging and drug delivery.
abstract: A novel strategy was utilized to develop a stable probe based on thiolated poly(ethylene glycol) (SH-PEG) and polyacrylic acid (PAA) functionalized gold nanorods (GNRs), following the attachment of an anti-cancer drug, doxorubicin (DOX), to obtain PAA-PEG-GNRs@DOX assemblies. Importantly, the obtained probe as a novel drug-delivery and fluorescent imaging agent for simultaneous imaging of and drug delivery to prostate cancer cells has also been demonstrated. In addition to designing PAA-PEG-GNRs that passively target tumor cells for cancer-fighting drug therapy, GNRs are also regarded as hyperthermia agents for photokilling cancer cells, so that the tumor would be attacked on two fronts simultaneously.
authors: School of Chemistry, Northeast Normal University, Changchun, PR China.
authors: Tingting
authors: T
authors: Wang
authors: Xuli
authors: X
authors: Zhang
authors: Ying
authors: Y
authors: Pan
authors: Xiumin
authors: X
authors: Miao
authors: Zhongmin
authors: Z
authors: Su
authors: Chungang
authors: C
authors: Wang
authors: Xiaomeng
authors: X
authors: Li
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000737:chemistry; D016503:Drug Delivery Systems; D004354:Drug Screening Assays, Antitumor; D006046:Gold / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging; D043942:Nanotubes / Q000737:chemistry; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy*; D011092:Polyethylene Glycols / Q000737:chemistry; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000180:Acrylic Resins; D000970:Antineoplastic Agents; D011092:Polyethylene Glycols; C006903:carbopol 940; D006046:Gold; D004317:Doxorubicin