title: K-acetylation and its enzymes: overview and new developments.
abstract: Lysine (K) acetylation refers to transfer of the acetyl moiety from acetyl-CoA to the ε-amino group of a lysine residue. This is posttranslational and reversible, with its level dynamically maintained by lysine acetyltransferases (KATs) and deacetylases (KDACs). Traditionally, eukaryotic KDACs have been referred to as HDACs (histone deacetylases). Recent proteomic studies have revealed that hundreds of bacterial proteins and thousands of eukaryotic proteins contain acetyl-lysine (AcK) residues, indicating that K-acetylomes are comparable to phosphoproteomes. The current challenges are to assign enzymes that execute specific acetylation events, to determine the impact of these events, and to relate this modification to other posttranslational modifications, cell signaling networks, and pathophysiology under different cellular and developmental contexts. In this chapter, we provide a brief overview about the acetylomes, KATs, HDACs, AcK-recognizing protein domains, and acetylation-modulating therapeutics, and emphasize the latest developments in related areas. The remaining chapters of the book focus on and cover various aspects of HDACs (both the Rpd3/Hda1 and sirtuin families), which shall provide novel insights into how to utilize these enzymes for developing a new generation of HDAC-related therapeutics.
authors: The Rosalind & Morris Goodman Cancer Research Center, McGill University, Montréal, QC, Canada.
authors: Juliette Adjo
authors: JA
authors: Aka
authors: Go-Woon
authors: GW
authors: Kim
authors: Xiang-Jiao
authors: XJ
authors: Yang
mesh_terms: D000107:Acetylation; D000123:Acetyltransferases / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology; D006655:Histone Deacetylases / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008239:Lysine; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational; D013234:Stem Cells / Q000187:drug effects / Q000201:enzymology; D013329:Structure-Activity Relationship
chemical_list: D056572:Histone Deacetylase Inhibitors; D000123:Acetyltransferases; C084723:acetyl-CoA - lysine N6-acetyltransferase; D006655:Histone Deacetylases; D008239:Lysine