title: Angustilobine and andranginine type indole alkaloids and an uleine-secovallesamine bisindole alkaloid from Alstonia angustiloba.
abstract: A total of 20 alkaloids were isolated from the leaf and stem-bark extracts of Alstonia angustiloba, of which two are hitherto unknown. One is an alkaloid of the angustilobine type (angustilobine C), while the other is a bisindole alkaloid angustiphylline, derived from the union of uleine and secovallesamine moieties. The structures of these alkaloids were established using NMR and MS analysis. Angustilobine C showed moderate cytotoxicity towards KB cells.
authors: Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors: Wai-Foong
authors: WF
authors: Ku
authors: Shin-Jowl
authors: SJ
authors: Tan
authors: Yun-Yee
authors: YY
authors: Low
authors: Kanki
authors: K
authors: Komiyama
authors: Toh-Seok
authors: TS
authors: Kam
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification; D031051:Alstonia / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D026121:Indole Alkaloids; D010936:Plant Extracts; C571139:andranginine; C571138:angustilobine C