title: Gold-catalyzed 1,2-difunctionalizations of aminoalkynes using only N- and O-containing oxidants.
abstract: We report two viable routes for the 1,2-difunctionalization of aminoalkynes using only oxidants. In the presence of a gold catalyst, nitrones enable the oxoamination of aminoalkynes 1 to form 2-aminoamides 2. With a suitable gold catalyst, nitrosobenzenes implement an alkyne/nitroso metathesis of the same substrates to give 2-oxoiminylamides 3. These two novel oxidations also provide 1,2-aminoalcohols with opposite regioselectivity via NaBH(4) reduction in situ.
authors: Department of Chemistry, National Tsing-Hua University, Hsinchu, Taiwan 30043, ROC.
authors: Anupam
authors: A
authors: Mukherjee
authors: Ramesh B
authors: RB
authors: Dateer
authors: Rupsha
authors: R
authors: Chaudhuri
authors: Sabyasachi
authors: S
authors: Bhunia
authors: Somnath Narayan
authors: SN
authors: Karad
authors: Rai-Shung
authors: RS
authors: Liu