title: High HPA-axis activation disrupts the link between liking and wanting with liking and wanting related brain signaling.
abstract: BACKGROUND
  Eating behavior changes under stress, i.e. during high HPA-axis activation.
  
  
  OBJECTIVE
  Assessment of effects of high versus low HPA-axis activation on liking and wanting related brain signaling in relevant regions.
  
  
  METHODS
  15 female subjects (21.5±0.4 years, BMI=22.2±0.4) completed fMRI scans on 2 days, in a fasted as well as a satiated condition on each day. The days were sorted by HPA-axis activation, resulting in two sufficiently separated HPA-axis states which were statistically confirmed (p<.05). During scans, subjects rated liking and wanting for food images; wanting indicated food choice for the subsequent meal. Energy-intake, hunger and fullness were additionally recorded.
  
  
  RESULTS
  Hunger changed significantly over the meal (p<.001). Energy intake was lower during the second meal (p<.001). Behavioral wanting was lower after breakfast (p<.01), behavioral liking did not change. During low HPA-activation, liking task related signaling (TRS) pre-meal in the anterior insula predicted behavioral liking, wanting TRS in the anterior insula, nucleus accumbens and thalamus predicted behavioral wanting. During high HPA-activation, these relationships were not present pre-meal, but post-meal behavioral liking was predicted in the nucleus accumbens and wanting in the caudate.
  
  
  CONCLUSIONS
  High HPA-axis activation disrupted and redirected the connection of behavioral liking/wanting with the specifically associated brain signaling in relevant regions.
authors: Top Institute Food and Nutrition, Wageningen, The Netherlands. j.born@maastrichtuniversity.nl
authors: Jurriaan M
authors: JM
authors: Born
authors: Mieke J I
authors: MJ
authors: Martens
authors: Femke
authors: F
authors: Rutters
authors: Sofie G T
authors: SG
authors: Lemmens
authors: Rainer
authors: R
authors: Goebel
authors: Margriet S
authors: MS
authors: Westerterp-Plantenga
mesh_terms: D000704:Analysis of Variance; D001921:Brain / Q000098:blood supply / Q000502:physiology*; D002755:Choice Behavior / Q000502:physiology; D004435:Eating; D004644:Emotions / Q000502:physiology*; D002149:Energy Intake / Q000502:physiology; D005215:Fasting / Q000502:physiology*; D005260:Female; D005518:Food Preferences / Q000502:physiology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007091:Image Processing, Computer-Assisted; D016014:Linear Models; D008279:Magnetic Resonance Imaging / Q000379:methods; D009042:Motivation / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D015398:Signal Transduction; D055815:Young Adult
chemical_list: D010100:Oxygen; D006854:Hydrocortisone