title: Structures of giant icosahedral eukaryotic dsDNA viruses.
abstract: In the last twenty years, numerous giant, dsDNA, icosahedral viruses have been discovered and assigned to the nucleocytoplasmic large dsDNA virus (NCLDV) clade. The major capsid proteins of these viruses consist of two consecutive jelly-roll domains, assembled into trimers, with pseudo 6-fold symmetry. The capsomers are assembled into arrays that have either p6 (as in Paramecium bursaria Chlorella virus-1) or p3 symmetry (as in Mimivirus). Most of the NCLDV viruses have a membrane that separates the nucleocapsid from the external capsid.
authors: Department of Chemistry, University of Texas at El Paso, 79968, USA.
authors: Chuan
authors: C
authors: Xiao
authors: Michael G
authors: MG
authors: Rossmann
mesh_terms: D000818:Animals; D036022:Capsid Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D004266:DNA Virus Infections / Q000821:virology*; D004267:DNA Viruses / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D056890:Eukaryota / Q000821:virology*; D006801:Humans; D014771:Virion / Q000737:chemistry / Q000235:genetics / Q000502:physiology
chemical_list: D036022:Capsid Proteins