title: Palliative excisional surgery for primary colorectal cancer in patients with incurable metastatic disease. Is there a survival benefit? A systematic review.
abstract: OBJECTIVE
  Patients with stage IV colorectal cancer with unresectable metastases can either receive chemotherapy or palliative resection of the primary lesion. In the absence of any randomized data the choice of initial treatment in stage IV colorectal cancer is not based on firm evidence.
  
  
  METHODS
  A search of MEDLINE, Pubmed, Embase and the Cochrane Library database was performed from 1980 to 2010 for studies comparing palliative resection in stage IV colorectal cancer with other treatment modalities. Audits and observational studies were excluded. Median survival was the primary outcome measure. The morbidity and mortality of surgical and nonsurgical treatments were compared.
  
  
  RESULTS
  Twenty-one studies (no randomized controlled trials) were identified. Most demonstrated a survival benefit for patients who underwent palliative resection. Multivariate analysis indicates that tumour burden and performance status are both major independent prognostic variables. Selection bias, incomplete follow up and nonstandardized reporting of complications make the data difficult to interpret.
  
  
  CONCLUSIONS
  The studies indicate that there may be a survival benefit for primary resection of colorectal cancer in stage IV disease. The findings suggest that resection of the primary tumour should be based on tumour burden and performance status rather than on the presence or absence of symptoms alone.
authors: Department of Colorectal Surgery, Calderdale and Huddersfield NHS Trust, Huddersfield, UK. suanwar@btinternnet.com
authors: S
authors: S
authors: Anwar
authors: M B
authors: MB
authors: Peter
authors: J
authors: J
authors: Dent
authors: N A
authors: NA
authors: Scott
mesh_terms: D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D006801:Humans; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D010166:Palliative Care; D016019:Survival Analysis; D047368:Tumor Burden