title: Impact of prohepcidin levels and iron parameters on early post-transplantation toxicities.
abstract: OBJECTIVE
  Recent reports show the adverse impact of pre-transplantation iron overload on the outcome of haematopoietic stem cell transplantation (HSCT). We studied the pre-transplantation serum iron (SI) parameters including prohepcidin levels - a regulatory peptide of systemic iron homeostasis - and their role in early post-transplantation toxicities in allogeneic HSCT recipients.
  
  
  METHODS
  One hundred consecutive patients [36 women and 64 men; median age 27·5 years (range 16-63 years)] who underwent allogeneic HSCT between September 2003 and October 2007 at Gazi University were included in the study.
  
  
  RESULTS
  Pre-transplantation serum prohepcidin levels did not show correlation with SI parameters and interleukin-6 levels (P>0·05). Prohepcidin levels were inversely correlated with the National Cancer Institute grade of mucositis (P=0·060), neutropenic fever (P<0·001), and the number of days with febrile neutropenia (P=0·003). SI levels were correlated with the severity of hepatotoxicity (P=0·015) while pre-transplantation transferrin saturation levels were positively correlated with the severity of hepatotoxicity (P=0·055), pulmonary toxicity (P=0·032), and sinusoidal obstruction syndrome (P=0·049). Pre-transplantation serum ferritin levels were positively correlated with the development of sinusoidal obstruction syndrome (P=0·010) and inversely correlated with the day of neutrophil engraftment (P=0·012). Overall survival was 41·26% with a median follow-up time of 13 months (range 0·0-60 months). Pre-transplantation serum prohepcidin levels and iron overload were not associated with survival in Cox regression analysis.
  
  
  CONCLUSIONS
  Our results suggest that pre-transplantation iron parameters and prohepcidin levels might predict some of the early post-transplantation toxicities, however, without an impact on overall survival.
authors: Department of Hematology, Faculty of Medicine, Gazi University, Bilkent-1 C, Ankara, Turkey. aysucak@gazi.edu.tr
authors: Sahika Zeynep
authors: SZ
authors: Akı
authors: Hatice
authors: H
authors: Paşaoğlu
authors: Zeynep Arzu
authors: ZA
authors: Yeğin
authors: Elif
authors: E
authors: Suyanı
authors: Canan Yılmaz
authors: CY
authors: Demirtaş
authors: Zübeyde Nur
authors: ZN
authors: Ozkurt
authors: Münci
authors: M
authors: Yağcı
authors: Gülsan Türköz
authors: GT
authors: Sucak
mesh_terms: D000293:Adolescent; D000328:Adult; D023181:Antimicrobial Cationic Peptides / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D005293:Ferritins / Q000097:blood; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000401:mortality; D064451:Hepcidins; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D007501:Iron / Q000097:blood*; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011498:Protein Precursors / Q000097:blood*; D014184:Transplantation, Homologous; D055815:Young Adult
chemical_list: D023181:Antimicrobial Cationic Peptides; D064451:Hepcidins; D015850:Interleukin-6; D011498:Protein Precursors; D002097:C-Reactive Protein; D005293:Ferritins; D007501:Iron