title: [Restless legs syndrome and depression].
abstract: Epidemiological studies report an odds ratio of 2-4 for major depression among patients with restless legs syndrome (RLS) compared with healthy controls. Also a high prevalence of RLS in populations of depressed patients is seen. Several possible explanations are proposed, such as dopamine dysfunction, sleep disturbances, shared diagnostic criteria and adverse effects of antidepressive treatment. There is a low degree of evidence for a treatment strategy when depression and RLS coexist. Furthermore, it is important to realize, that some antidepressants can induce or worsen RLS.
authors: Center for Psykiatrisk Forskning, Aarhus Universitetshospital, Risskov, Skovagervej 2, 8240 Risskov, Denmark. johannes.rasmussen@gmail.com
authors: Johannes
authors: J
authors: Rasmussen
authors: Poul
authors: P
authors: Videbech
mesh_terms: D000928:Antidepressive Agents / Q000009:adverse effects; D003865:Major Depressive Disorder / Q000150:complications* / Q000188:drug therapy; D018491:Dopamine Agonists / Q000009:adverse effects / Q000627:therapeutic use; D018492:Dopamine Antagonists / Q000009:adverse effects; D019317:Evidence-Based Medicine; D006801:Humans; D017286:Polysomnography; D012148:Restless Legs Syndrome / Q000139:chemically induced / Q000150:complications* / Q000188:drug therapy
chemical_list: D000928:Antidepressive Agents; D018491:Dopamine Agonists; D018492:Dopamine Antagonists