title: Image reconstruction from limited angle projections collected by multisource interior x-ray imaging systems.
abstract: A multisource x-ray interior imaging system with limited angle scanning is investigated to study the possibility of building an ultrafast micro-CT for dynamic small animal imaging, and two methods are employed to perform interior reconstruction from a limited number of projections collected by the multisource interior x-ray system. The first is total variation minimization with the steepest descent search (TVM-SD) and the second is total difference minimization with soft-threshold filtering (TDM-STF). Comprehensive numerical simulations and animal studies are performed to validate the associated reconstructed methods and demonstrate the feasibility and application of the proposed system configuration. The image reconstruction results show that both of the two reconstruction methods can significantly improve the image quality and the TDM-SFT is slightly superior to the TVM-SD. Finally, quantitative image analysis shows that it is possible to make an ultrafast micro-CT using a multisource interior x-ray system scheme combined with the state-of-the-art interior tomography.
authors: Department of Radiology, Division of Radiologic Sciences, Wake Forest University Health Sciences, Winston-Salem, NC, 27157, USA.
authors: Baodong
authors: B
authors: Liu
authors: Ge
authors: G
authors: Wang
authors: Erik L
authors: EL
authors: Ritman
authors: Guohua
authors: G
authors: Cao
authors: Jianping
authors: J
authors: Lu
authors: Otto
authors: O
authors: Zhou
authors: Li
authors: L
authors: Zeng
authors: Hengyong
authors: H
authors: Yu
mesh_terms: D000818:Animals; D005240:Feasibility Studies; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D051379:Mice; D009716:Numerical Analysis, Computer-Assisted; D019047:Phantoms, Imaging; D016012:Poisson Distribution; D013997:Time Factors; D055114:X-Ray Microtomography / Q000379:methods*