title: Surgical therapy of advanced ligature-induced peri-implantitis defects: cone-beam computed tomographic and histological analysis.
abstract: OBJECTIVE
  To evaluate radiological bone level (RBL) (i.e. cone-beam computed tomography) and histological bone levels (HBL) as well as re-osseointegration [bone-to-implant contact (BIC)] after surgical resective (i.e. implantoplasty) and/or regenerative therapy of advanced ligature-induced peri-implantitis in dogs.
  
  
  METHODS
  At all defect sites (n=6 dogs, n=48 implants), the intrabony component was filled with a particulate bovine-derived natural bone mineral (NBM). The supracrestal component was treated by either the application of an equine bone block (EB) or implantoplasty. In a split-mouth design, NBM and EB were soak-loaded with recombinant human bone morphogenetic protein (rhBMP)-2 or sterile saline. All sites were covered by a native collagen membrane and left to heal in a submerged position for 12 weeks.
  
  
  RESULTS
  A premature wound exposure was observed at nine defect sites. Mean RBL and HBL values were lowest in the P+rhBMP-2 group, reaching statistical significance when compared with the EB group. Mean BIC values were comparable in all groups. Within-group comparisons commonly revealed a close correlation between RBL and HBL values.
  
  
  CONCLUSIONS
  It was concluded that (i) in all groups the investigations failed to predictably obtain complete defect resolution, (ii) the surgical procedure was associated with high exposure rates, and (iii) RBL was closely correlated with HBL.
authors: Department of Oral Surgery, Heinrich Heine University, Düsseldorf, Germany. Frank.Schwarz@med.uni-dueseldorf.de
authors: Frank
authors: F
authors: Schwarz
authors: Narja
authors: N
authors: Sahm
authors: Ilja
authors: I
authors: Mihatovic
authors: Vladimir
authors: V
authors: Golubovic
authors: Jürgen
authors: J
authors: Becker
mesh_terms: D016301:Alveolar Bone Loss / Q000601:surgery*; D000818:Animals; D055396:Bone Morphogenetic Protein 2 / Q000627:therapeutic use; D001861:Bone Regeneration; D018786:Bone Substitutes; D016025:Bone Transplantation; D054893:Cone-Beam Computed Tomography / Q000379:methods*; D004285:Dogs; D008026:Ligation; D015588:Observer Variation; D016348:Osseointegration; D057873:Peri-Implantitis / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D011994:Recombinant Proteins / Q000627:therapeutic use; D019651:Plastic Surgery Procedures
chemical_list: D055396:Bone Morphogenetic Protein 2; D018786:Bone Substitutes; D011994:Recombinant Proteins