title: Caucasicosides E-M, furostanol glycosides from Helleborus caucasicus.
abstract: Nine furostanol glycosides, namely caucasicosides E-M, were isolated from the MeOH extract of the leaves of Helleborus caucasicus, along with 11 known compounds including nine furostanol glycosides, a bufadienolide and an ecdysteroid. Their structures were established by the extensive use of 1D and 2D NMR experiments along with ESIMS(n) analyses. The steroidal composition of leaves of H. caucasicus shows as particular feature the occurrence of steroidal compounds belonging to the 5β series, unusual for Helleborus species, and in particular, caucasicosides F-H are based on a 5β-polyhydroxylated steroidal aglycon never reported before.
authors: Institute of Pharmacochemistry, P. Sarajishvili Street 36, 0159 Tbilisi, Georgia.
authors: Tamar
authors: T
authors: Muzashvili
authors: Angela
authors: A
authors: Perrone
authors: Assunta
authors: A
authors: Napolitano
authors: Ether
authors: E
authors: Kemertelidze
authors: Cosimo
authors: C
authors: Pizza
authors: Sonia
authors: S
authors: Piacente
mesh_terms: D002018:Bufanolides / Q000737:chemistry / Q000302:isolation & purification; D026461:Ecdysteroids / Q000737:chemistry / Q000302:isolation & purification; D006027:Glycosides / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification; D039322:Helleborus / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D013261:Sterols / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D002018:Bufanolides; D026461:Ecdysteroids; D006027:Glycosides; D010936:Plant Extracts; D013261:Sterols; C571140:caucasicoside