title: Neuroendocrine carcinoma of the apocrine glands of the anal sac in a dog.
abstract: A perianal subcutaneous tumor involving the anal sac developed in an 8-year-old male mixed Labrador Retriever dog. Histologically, this tumor showed typical features of the solid-type carcinoma of the apocrine glands of the anal sac. However, neoplastic cells were immunoreactive for cytokeratin 8, chromogranin A, vasoactive intestinal peptide, neuron-specific enolase, and synaptophysin, and negative for S-100 protein, α-smooth muscle actin, vimentin, glucagon, insulin, somatostatin, carcinoembryonic antigen, serotonin, and parathyroid hormone-related protein. Considering the distribution of chromogranin A-positive cells within the anal sac apocrine glands, this tumor was diagnosed as neuroendocrine carcinoma originating from the apocrine glands of the anal sac.
authors: Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan.
authors: Bunichiro
authors: B
authors: Ogawa
authors: Eriko
authors: E
authors: Taniai
authors: Hitomi
authors: H
authors: Hayashi
authors: Masako
authors: M
authors: Imaoka
authors: Noboru
authors: N
authors: Machida
authors: Kunitoshi
authors: K
authors: Mitsumori
authors: Makoto
authors: M
authors: Shibutani
mesh_terms: D000695:Anal Sacs / Q000473:pathology*; D000818:Animals; D001050:Apocrine Glands / Q000473:pathology*; D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000175:diagnosis / Q000473:pathology*; D004285:Dogs; D008297:Male; D012983:Soft Tissue Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*