title: Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims.
abstract: Teenage suicide is a major public health concern, but its neurobiology is not well understood. Proinflammatory cytokines play an important role in stress and in the pathophysiology of depression-two major risk factors for suicide. Cytokines are increased in the serum of patients with depression and suicidal behavior; however, it is not clear if similar abnormality in cytokines occurs in brains of suicide victims. We therefore measured the gene and protein expression levels of proinflammatory cytokines interleukin (IL)-1β, IL-6, and tissue necrosis factor (TNF)-α in the prefrontal cortex (PFC) of 24 teenage suicide victims and 24 matched normal control subjects. Our results show that the mRNA and protein expression levels of IL-1β, IL-6, and TNF-α were significantly increased in Brodmann area 10 (BA-10) of suicide victims compared with normal control subjects. These results suggest an important role for IL-1β, IL-6, and TNF-α in the pathophysiology of suicidal behavior and that proinflammatory cytokines may be an appropriate target for developing therapeutic agents.
authors: Department of Psychiatry, University of Illinois at Chicago, 1601 W. Taylor Street, Chicago, IL 60612, USA. Gnpandey@psych.uic.edu
authors: Ghanshyam N
authors: GN
authors: Pandey
authors: Hooriyah S
authors: HS
authors: Rizavi
authors: Xinguo
authors: X
authors: Ren
authors: Jawed
authors: J
authors: Fareed
authors: Debra A
authors: DA
authors: Hoppensteadt
authors: Rosalinda C
authors: RC
authors: Roberts
authors: Robert R
authors: RR
authors: Conley
authors: Yogesh
authors: Y
authors: Dwivedi
mesh_terms: D000293:Adolescent; D002648:Child; D016207:Cytokines / Q000235:genetics / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D008297:Male; D011180:Postmortem Changes; D017397:Prefrontal Cortex / Q000378:metabolism* / Q000473:pathology*; D012333:RNA, Messenger / Q000378:metabolism; D013405:Suicide; D055815:Young Adult
chemical_list: D016207:Cytokines; D012333:RNA, Messenger