title: Carboxymethyl flavonoids and a monoterpene glucoside from Selaginella moellendorffii.
abstract: A new dihydroflavone, 5-carboxymethyl-7,4'-dihydroxyflavonone (1), and its glucoside 5-carboxymethyl-7,4'-dihydroxyflavonone-7-O-β-D: -glucopyranoside (2), and one new monoterpene glucoside, (4Z,6E)-2,7-dimethyl-8-hydroxyocta-4,6-dienoic acid 8-O-β-D: -glucopyranoside (3), were isolated from the whole plants of Selaginella moellendorffii. Their structures were determined by spectroscopic methods and chemical transformation. Compound 2 was evaluated for the ability to enhance glucose consumption in normal and insulin-resistant L6 muscle cells induced by high concentrations of insulin and glucose. Glucose consumption in insulin-resistant cells (but not in normal cells) was increased 15.2 ± 3.3% (p < 0.01) by compound 2 at a concentration of 0.1 μM in the presence of insulin (1 nM).
authors: Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
authors: Hong-Sheng
authors: HS
authors: Wang
authors: Ling
authors: L
authors: Sun
authors: Yue-Hu
authors: YH
authors: Wang
authors: Ya-Na
authors: YN
authors: Shi
authors: Gui-Hua
authors: GH
authors: Tang
authors: Fu-Wei
authors: FW
authors: Zhao
authors: Hong-Mei
authors: HM
authors: Niu
authors: Chun-Lin
authors: CL
authors: Long
authors: Ling
authors: L
authors: Li
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007333:Insulin Resistance / Q000502:physiology; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry; D032446:Myoblasts / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D032503:Selaginellaceae / Q000737:chemistry*
chemical_list: C552458:5-carboxymethyl-4',7-dihydroxyflavone; C570592:5-carboxymethyl-7,4'-dihydroxyflavonone-7-O-glucopyranoside; D004365:Drugs, Chinese Herbal; D044950:Flavanones; D047309:Flavones; D005419:Flavonoids; D005960:Glucosides; D039821:Monoterpenes; D010936:Plant Extracts; D005947:Glucose