title: Hyaline glomerulopathy with tubulo-fibrillary deposits in young ddY mice.
abstract: Hyaline glomerulopathy with tubulo-fibrillary deposits was observed in two young female ddY mice. One of the mice showed gross systemic edema and bilateral enlargement and pale color of the kidneys, whereas no significant gross findings were noted in the other mouse. Microscopically, a large number of the glomeruli in both mice were enlarged because of diffuse and global deposition of amorphous eosinophilic materials. The deposits were negatively stained with Congo red and positively stained with IgG, IgM, IgA, C3, and periodic acid-Schiff. Electron microscopic examination revealed microtubular and fibrillary deposits with diameters of 80-100 and 9-16 nm, respectively, in the subendothelial space of the glomeruli. These features are histopathologically similar to immunotactoid glomerulopathy or fibrillary glomerulonephritis according to the classification of human glomerular lesions. Understanding of these characteristics of hyaline glomerulopathy in ddY mice is essential when evaluating pharmacological, pharmacokinetic, and toxicological studies using this mouse strain.
authors: Safety Research Laboratories, Dainippon Sumitomo Pharma Co Ltd, Osaka, Japan.
authors: Mami
authors: M
authors: Kouchi
authors: Kaoru
authors: K
authors: Toyosawa
authors: Izumi
authors: I
authors: Matsumoto
authors: Yoshiko
authors: Y
authors: Michimae
authors: Tomoaki
authors: T
authors: Tochitani
authors: Takatoshi
authors: T
authors: Koujitani
authors: Kazuo
authors: K
authors: Okimoto
authors: Hitoshi
authors: H
authors: Funabashi
authors: Takaki
authors: T
authors: Seki
mesh_terms: D000818:Animals; D005260:Female; D005921:Glomerulonephritis / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D006818:Hyalin / Q000378:metabolism*; D007150:Immunohistochemistry; D007678:Kidney Glomerulus / Q000473:pathology* / Q000648:ultrastructure*; D051379:Mice; D008815:Mice, Inbred Strains