title: Malignant potential of oral and labial chronic discoid lupus erythematosus: a clinicopathological study of 87 cases.
abstract: OBJECTIVE
  To investigate clinicopathological features and identify clinicopathological risk factors for the malignant transformation of oral and labial chronic discoid lupus erythematosus (DLE) in a relatively large number of patients from China.
  
  
  RESULTS
  A total of 87 patients with clinical and histopathological diagnosis of DLE between 1993 and 2009 were reviewed retrospectively in our hospital. The average age at diagnosis was 51.7 years, with a male:female ratio of 1:1.8. The lower lip was the most common site (71.3%). We documented six DLE patients with malignant transformation. On univariate analysis, patients with high-risk dysplasia (P = 0.002) or aged >60 (P = 0.045) were associated with DLE malignant transformation, but gender, lesion site, smoking and alcohol intake were not risk factors. On multivariate analysis, high-risk dysplasia was a significant indicator for DLE malignant transformation. High-risk dysplasia was associated with a 14.24-fold [95% confidence interval (95% CI), 1.97-102.88; P = 0.008] increased risk of malignant transformation, compared with non/low-risk dysplasia.
  
  
  CONCLUSIONS
  The utilization of high-risk dysplasia as a significant indicator for evaluating malignant transformation risk in patients with DLE is suggested, which may be helpful to guide treatment selection.
authors: Shanghai Key Laboratory of Stomatology, Department of Oral Mucosal Diseases, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, China. liuweb@hotmail.com
authors: Wei
authors: W
authors: Liu
authors: Zheng-Yu
authors: ZY
authors: Shen
authors: Li-Jia
authors: LJ
authors: Wang
authors: Yu-Hua
authors: YH
authors: Hu
authors: Xue-Ming
authors: XM
authors: Shen
authors: Zeng-Tong
authors: ZT
authors: Zhou
authors: Jiang
authors: J
authors: Li
mesh_terms: D002471:Cell Transformation, Neoplastic; D005260:Female; D006801:Humans; D008046:Lip / Q000473:pathology*; D008179:Lupus Erythematosus, Discoid / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000209:etiology / Q000473:pathology*; D011230:Precancerous Conditions / Q000209:etiology / Q000473:pathology*; D012189:Retrospective Studies