title: Estrogen-like response of perfluorooctyl iodide in male medaka (Oryzias latipes) based on hepatic vitellogenin induction.
abstract: Using the in vivo male medaka model, we investigated the estrogen-like response of perfluorooctyl iodide (PFOI) which is a potential source of perfluorinated carboxylic acids. Using real-time quantitative polymerase chain reaction, the expression levels of related estrogenic genes including estrogenic receptor α (ERα), ERβ, vitellogenin I (VTG I), and VTG II in the livers of male medaka exposed to PFOI were analyzed. The results showed that PFOI upregulated the expression levels of the tested genes in a dose-dependent manner. VTG protein levels increased in both dose- and time-dependent manners due to PFOI exposure. The results suggested that PFOI is a potential estrogenic compound.
authors: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, People's Republic of China.
authors: Yichen
authors: Y
authors: Wang
authors: Qunfang
authors: Q
authors: Zhou
authors: Chang
authors: C
authors: Wang
authors: Nuoya
authors: N
authors: Yin
authors: Zhuona
authors: Z
authors: Li
authors: Jiyan
authors: J
authors: Liu
authors: Guibin
authors: G
authors: Jiang
mesh_terms: D000818:Animals; D047628:Estrogen Receptor alpha / Q000235:genetics / Q000378:metabolism; D047629:Estrogen Receptor beta / Q000235:genetics / Q000378:metabolism; D004967:Estrogens / Q000633:toxicity*; D005466:Fluorocarbons / Q000633:toxicity*; D006842:Hydrocarbons, Brominated; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009990:Oryzias / Q000378:metabolism*; D015854:Up-Regulation; D014819:Vitellogenins / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D004967:Estrogens; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; D014819:Vitellogenins; C003072:perflubron