title: Fertility, infertility and thrombophilia.
abstract: Hypercoagulation has been reported in some studies to be associated with reproductive failures, such as unexplained infertility, IVF implantation failure and recurrent fetal losses. Many pregnancy-related disorders have been interpreted as consequences of impaired microvascular function and might be viewed as a mild form of venous thromboembolic disease. In the absence of clinical guidelines, there is a need for an evidence base regarding thrombophilic screening and antithrombotic therapy in cases of reproductive failure. This article will focus on the controversial effect of congenital and acquired thrombophilia on human fertility, and will review the English literature for relevant studies identified by searching PubMed(®) results between January 1966-November 2010 using the key words: 'thrombophilia', 'fertility' and 'infertility'.
authors: The Ruth & Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel. amir.kuperman@naharia.health.gov.il
authors: Amir
authors: A
authors: Kuperman
authors: Pierpaolo
authors: P
authors: Di Micco
authors: Benjamin
authors: B
authors: Brenner
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D000925:Anticoagulants / Q000008:administration & dosage; D005260:Female; D005298:Fertility; D005307:Fertilization in Vitro; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D007246:Infertility / Q000151:congenital* / Q000209:etiology*; D011247:Pregnancy; D016032:Randomized Controlled Trials as Topic; D019851:Thrombophilia / Q000150:complications* / Q000151:congenital; D017211:Treatment Failure
chemical_list: D000925:Anticoagulants; D006493:Heparin