title: The impact of age at transfer from pediatric to adult-oriented care on renal allograft survival.
abstract: Immaturity among individuals transferred from pediatric to adult-oriented care at a young age may leave them vulnerable to higher graft failure risks than in individuals transferred older. We sought to determine the impact of age at transfer on renal allograft failure rates. We evaluated graft failure rates among 440 kidney recipients recorded in the UNOS database (1987-2007), who had been transferred from pediatric to adult care. Transfers were identified using the center codes recorded at yearly data collection. Failure rates for those transferred early (<21 yr old) were compared with rates for those transferred late (≥21 yr old); time-dependent Cox models were used to estimate the additional risk of graft failure associated with early vs. late transfer. The age-standardized failure rate was 12.9 per 100 person-years among those transferred early, and 8.7 per 100 person-years among those transferred late. Compared with individuals the same age who had transferred late, graft failure rates were 58% higher ([95% confidence interval: 7%, 134%], p = 0.02) among those who had transferred early. Younger age at transfer to adult care is associated with higher graft failure rates. Transfer to adult-oriented care at <21 yr of age should be undertaken with caution.
authors: Department of Pediatrics, Division of Nephrology, McGill University Faculty of Medicine, Montreal, QC, Canada. beth.foster@muhc.mcgill.ca
authors: Bethany J
authors: BJ
authors: Foster
authors: Robert W
authors: RW
authors: Platt
authors: Mourad
authors: M
authors: Dahhou
authors: Xun
authors: X
authors: Zhang
authors: Lorraine E
authors: LE
authors: Bell
authors: James A
authors: JA
authors: Hanley
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D015331:Cohort Studies; D016208:Databases, Factual; D005260:Female; D005919:Glomerular Filtration Rate; D006084:Graft Rejection; D006801:Humans; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012306:Risk; D014184:Transplantation, Homologous / Q000379:methods*