title: The schizophrenia risk gene ZNF804A influences the antipsychotic response of positive schizophrenia symptoms.
abstract: Genetic factors determining the response to antipsychotic treatment in schizophrenia are poorly understood. A new schizophrenia susceptibility gene, the zinc-finger gene ZNF804A, has recently been identified. To assess the pharmacogenetic importance of this gene, we treated 144 schizophrenia patients and assessed the response of positive and negative symptoms by PANSS. Patients homozygous for the ZNF804A risk allele for schizophrenia (rs1344706 AA) showed poorer improvement of positive symptoms (7.35 ± 0.46) compared to patients with a protective allele (9.41 ± 0.71, P = 0.022). This provides further evidence that ZNF804A is of functional relevance to schizophrenia and indicates that ZNF804A may be a novel target for pharmacological interventions.
authors: Department of Psychiatry and Psychotherapy, University of Bonn, Germany. rainald.moessner@ukb.uni-bonn.de
authors: Rainald
authors: R
authors: Mössner
authors: Anna
authors: A
authors: Schuhmacher
authors: Michael
authors: M
authors: Wagner
authors: Leonhard
authors: L
authors: Lennertz
authors: Anja
authors: A
authors: Steinbrecher
authors: Boris B
authors: BB
authors: Quednow
authors: Dan
authors: D
authors: Rujescu
authors: Marcella
authors: M
authors: Rietschel
authors: Wolfgang
authors: W
authors: Maier
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012559:Schizophrenia / Q000188:drug therapy* / Q000235:genetics*; D012737:Sex Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D051741:Kruppel-Like Transcription Factors; C540527:ZNF804A protein, human