title: Local use-dependent sleep; synthesis of the new paradigm.
abstract: The logic and potential mechanisms for a new paradigm, the local use-dependent view of sleep as a distributed dynamic process in brain, are presented. This new paradigm is needed because the current dominant top-down imposition of sleep on the brain by sleep regulatory centers is either silent or is of inadequate explanatory value for many well-known sleep phenomena, e.g. sleep inertia. Two mechanistic falsifiable hypotheses linking sleep to cell use and the emergence of sleep/wake states are presented. These hypotheses are not mutually exclusive and both firmly link sleep to activity-dependent epigenetic brain plasticity and the need to integrate and balance waking activity induced-network connectivity changes. The views presented herein emphasize the inseparability of sleep mechanisms from a connectivity sleep function.
authors: WWAMI Medical Education Program and the Sleep and Performance Research Center, Washington State University, Spokane, WA 99210-1495, USA. krueger@vetmed.wsu.edu
authors: James M
authors: JM
authors: Krueger
authors: Giulio
authors: G
authors: Tononi
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000502:physiology*; D006801:Humans; D008959:Models, Neurological; D012890:Sleep / Q000502:physiology*