title: Role of ischemia-modified albumin and total homocysteine in estimating symptomatic lacunar infarction in type 2 diabetic patients.
abstract: OBJECTIVE
  To investigate whether ischemia-modified albumin (IMA) is reliable for early diagnosing symptomatic lacunar infarction (SLI) in type 2 diabetics.
  
  
  METHODS
  Ninety-seven consecutive diabetic patients, 47 with SLI, and 45 healthy controls were enrolled. Serum IMA and plasma total homocysteine (tHcy) were measured on an autoanalyzer and evaluated in distinguishing SLI.
  
  
  RESULTS
  Serum IMA levels were 97.35 ± 5.25 U/L in the healthy control group, 103.26 ± 7.43 U/L in the non-SLI group, and 139.84 ± 20.00 U/L in the SLI group. Plasma tHcy levels were 8.08 ± 1.82 μmol/L, 11.31 ± 3.03 μmol/L, and 13.10 ± 3.67 μmol/L, respectively. The differences in IMA and tHcy levels were statistically significant for all groups (p<0.05). Receiver operating characteristic curve analyses revealed the areas under curve were 0.866 for IMA and 0.352 for tHcy.
  
  
  CONCLUSIONS
  This study indicates that IMA was significantly elevated in the acute phase of SLI and more sensitive than tHcy in distinguishing SLI.
authors: Department of Endocrinology and Metabolism, Affiliated Huai'an Hospital of Xuzhou Medical College, No. 62 Huaihai South Road, Huai'an 223002, China. mashaogang@163.com
authors: Shao-gang
authors: SG
authors: Ma
authors: Wei
authors: W
authors: Xu
authors: Chun-ling
authors: CL
authors: Wei
authors: Xiao-juan
authors: XJ
authors: Wu
authors: Bing
authors: B
authors: Hong
authors: Zeng-jun
authors: ZJ
authors: Wang
authors: Hai-rong
authors: HR
authors: Hao
authors: Hui-qin
authors: HQ
authors: Guo
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000175:diagnosis; D012372:ROC Curve; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D059409:Stroke, Lacunar / Q000097:blood* / Q000175:diagnosis
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; D006710:Homocysteine; D000075462:Serum Albumin, Human