title: [Is bone biopsy necessary for the diagnosis of metabolic bone diseases? Necessity of bone biopsy].
abstract: Histological analysis of undecalcified bone biopsy specimens is a valuable clinical and research tool for studying the etiology, pathogenesis and treatment of metabolic bone diseases. In case of osteoporosis, bone biopsy is not usually required for the diagnosis ; however, bone histomorphometry may be useful in rare cases with unusual skeletal fragility. Bone histomorphometry also provides valuable information on the mechanism of action, safety and efficacy of new anti-osteoporosis drugs. Bone histomorphometry is useful for the diagnosis and the assessment of treatment response in rickets/osteomalacia and in CKD-MBD (chronic kidney disease-mineral and bone disorders) . In Japan, bone biopsy is often performed to establish the diagnosis of Paget's disease of bone, especially to differentiate it from metastatic bone disease.
authors: Ito Bone Histomorphometry Institute, Japan.
authors: Akemi
authors: A
authors: Ito
authors: Aiji
authors: A
authors: Yajima
mesh_terms: D001706:Biopsy; D001851:Bone Diseases, Metabolic / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D001842:Bone and Bones / Q000473:pathology*; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000175:diagnosis; D003937:Diagnosis, Differential; D006801:Humans; D010001:Osteitis Deformans / Q000175:diagnosis; D010018:Osteomalacia / Q000175:diagnosis; D010024:Osteoporosis / Q000175:diagnosis