title: Metastatic lung adenocarcinoma to the iris mimicking Cogan-Reese syndrome.
abstract: OBJECTIVE
  Case report of metastatic lung cancer to the iris mimicking Cogan-Reese syndrome.
  
  
  METHODS
  A 61-year-old female with a history of non-small cell lung cancer presented with unilateral elevated intraocular pressure (IOP) and multiple hyperpigmented iris nodules associated with an anterior iris membrane. The patient's IOP could not be controlled medically, so she underwent trabeculectomy with simultaneous iris biopsy.
  
  
  RESULTS
  Histopathology revealed proliferation of glandular epithelium on the iris surface consistent with metastatic lung adenocarcinoma.
  
  
  CONCLUSIONS
  Iris metastases have varied presentations, and one must consider metastatic disease in any patient with a history of cancer presenting with iris lesions. The formation of an iris membrane and nodules by metastatic adenocarcinoma to the iris may mimic Cogan-Reese syndrome.
authors: Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma College of Medicine, Oklahoma City, OK 73104, USA.
authors: Ben J
authors: BJ
authors: Harvey
authors: Hans E
authors: HE
authors: Grossniklaus
authors: Matthew P
authors: MP
authors: Traynor
authors: Steven R
authors: SR
authors: Sarkisian
authors: Donald U
authors: DU
authors: Stone
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary* / Q000601:surgery; D014408:Biomarkers, Tumor / Q000378:metabolism; D003316:Corneal Diseases / Q000175:diagnosis*; D003886:Descemet Membrane / Q000473:pathology*; D003937:Diagnosis, Differential; D004728:Endothelium, Corneal / Q000473:pathology*; D005260:Female; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D032801:Iridectomy; D015811:Iris Neoplasms / Q000556:secondary* / Q000601:surgery; D008175:Lung Neoplasms / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D013577:Syndrome; D014130:Trabeculectomy; D014792:Visual Acuity / Q000502:physiology
chemical_list: D014408:Biomarkers, Tumor