title: Association between Ω3 and Ω6 fatty acid intakes and serum inflammatory markers in COPD.
abstract: Dietary intake of polyunsaturated fatty acids, including omega-3 and omega-6, could modulate chronic obstructive pulmonary disease (COPD) persistent inflammation. We aimed to assess the relationship between dietary intake of omega-3 and omega-6 fatty acids and serum inflammatory markers in COPD. A total of 250 clinically stable COPD patients were included. Dietary data of the last 2 years were assessed using a validated food frequency questionnaire (122 items), which provided levels of three omega-3 fatty acids: docosahexaenoic acid, eicosapentaenoic acid and α-linolenic acid (ALA); and two omega-6 fatty acids: linoleic acid and arachidonic acid (AA). Inflammatory markers [C-reactive protein (CRP), interleukin (IL)-6, IL-8 and tumor necrosis factor alpha (TNFα)] were measured in serum. Fatty acids and inflammatory markers were dichotomised according to their median values, and their association was assessed using multivariate logistic regression. Higher intake of ALA (an anti-inflammatory omega-3 fatty acid) was associated with lower TNFα concentrations [adjusted odds ratio (OR)=0.46; P=.049]. Higher AA intake (a proinflammatory omega-6 fatty acid) was related to higher IL-6 (OR=1.96; P=.034) and CRP (OR=1.95; P=.039) concentrations. Therefore, this study provides the first evidence of an association between dietary intake of omega-3 and omega-6 fatty acids and serum inflammatory markers in COPD patients.
authors: Centre for Research in Environmental Epidemiology-CREAL, Barcelona, Spain.
authors: Jordi
authors: J
authors: de Batlle
authors: Jaume
authors: J
authors: Sauleda
authors: Eva
authors: E
authors: Balcells
authors: Federico P
authors: FP
authors: Gómez
authors: Michelle
authors: M
authors: Méndez
authors: Esther
authors: E
authors: Rodriguez
authors: Esther
authors: E
authors: Barreiro
authors: Jaume J
authors: JJ
authors: Ferrer
authors: Isabelle
authors: I
authors: Romieu
authors: Joaquim
authors: J
authors: Gea
authors: Josep M
authors: JM
authors: Antó
authors: Judith
authors: J
authors: Garcia-Aymerich
mesh_terms: D000368:Aged; D016718:Arachidonic Acid / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D003430:Cross-Sectional Studies; D004041:Dietary Fats / Q000008:administration & dosage*; D004281:Docosahexaenoic Acids / Q000097:blood; D015118:Eicosapentaenoic Acid / Q000097:blood; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D019787:Linoleic Acid / Q000097:blood; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood*; D011795:Surveys and Questionnaires; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D017962:alpha-Linolenic Acid / Q000097:blood
chemical_list: D015415:Biomarkers; D004041:Dietary Fats; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D017962:alpha-Linolenic Acid; D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid; D002097:C-Reactive Protein; D019787:Linoleic Acid; D015118:Eicosapentaenoic Acid