title: Nanoparticles in the treatment and diagnosis of neurological disorders: untamed dragon with fire power to heal.
abstract: The incidence of neurological diseases of unknown etiology is increasing, including well-studied diseases such as Alzhiemer's, Parkinson's, and multiple sclerosis. The blood-brain barrier provides protection for the brain but also hinders the treatment and diagnosis of these neurological diseases, because the drugs must cross the blood-brain barrier to reach the lesions. Thus, attention has turned to developing novel and effective delivery systems that are capable of carrying drug and that provide good bioavailability in the brain. Nanoneurotechnology, particularly application of nanoparticles in drug delivery, has provided promising answers to some of these issues in recent years. Here we review the recent advances in the understanding of several common forms of neurological diseases and particularly the applications of nanoparticles to treat and diagnose them. In addition, we discuss the integration of bioinformatics and modern genomic approaches in the development of nanoparticles.
  
  
  BACKGROUND
  In this review paper, applications of nanotechnology-based diagnostic methods and therapeutic modalities are discussed addressing a variety of neurological disorders, with special attention to blood-brain barrier delivery methods. These novel nanomedicine approaches are expected to revolutionize several aspects of clinical neurology.
authors: Laboratory of Immunology and Molecular Biomedical Research, Centre for Biotechnology and Interdisciplinary Biosciences (BioDeakin), Institute for Technology & Research Innovation, Deakin University, Geelong, Victoria, Australia. jagat.kanwar@deakin.edu.au
authors: Jagat R
authors: JR
authors: Kanwar
authors: Xueying
authors: X
authors: Sun
authors: Vasu
authors: V
authors: Punj
authors: Bhasker
authors: B
authors: Sriramoju
authors: Rajiv R
authors: RR
authors: Mohan
authors: Shu-Feng
authors: SF
authors: Zhou
authors: Ashok
authors: A
authors: Chauhan
authors: Rupinder K
authors: RK
authors: Kanwar
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism / Q000473:pathology; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D053758:Nanoparticles; D009422:Nervous System Diseases / Q000175:diagnosis* / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology