title: [Positive effect of cytoflavin on metabolic status changes in patients with burn disorder].
abstract: Complex clinical and laboratory examination of 60 patients with moderate level of burn damage included determination of the content of intermediate products of lipid peroxidation (LPO) (malonic dialdehyde, diene conjugate, SH groups and tocopherol) in blood and peripheral zone of the skin and hypodermic tissue. At the same time, the activity of superoxide distumase (SOD) and catalase was evaluated. This examination was performed on the first and third days after injury, in the period of burn shock. In the course of conventional therapy, burn shock was characterized by LPO intensification and insufficiency of the blood antioxidant system. Cytoflavin included into the conventional therapy produces improvement in metabolic changes due to the activation of blood SOD and catalase and an increase in tocopherol (vitaminE) content in the blood.
authors: N V
authors: NV
authors: Polutova
authors: N V
authors: NV
authors: Ostrovskiĭ
authors: M G
authors: MG
authors: Romantsov
authors: N P
authors: NP
authors: Chesnokova
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage* / Q000627:therapeutic use; D002056:Burns / Q000188:drug therapy* / Q000503:physiopathology; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood; D004338:Drug Combinations; D005260:Female; D005486:Flavin Mononucleotide / Q000008:administration & dosage* / Q000627:therapeutic use; D018869:Heat-Shock Response / Q000187:drug effects*; D006801:Humans; D007290:Inosine Diphosphate / Q000008:administration & dosage* / Q000627:therapeutic use; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D008875:Middle Aged; D009536:Niacinamide / Q000008:administration & dosage* / Q000627:therapeutic use; D013386:Succinates / Q000008:administration & dosage* / Q000627:therapeutic use; D013482:Superoxide Dismutase / Q000097:blood; D014810:Vitamin E / Q000097:blood
chemical_list: D000975:Antioxidants; D004338:Drug Combinations; D013386:Succinates; C507879:cytoflavin; D014810:Vitamin E; D009536:Niacinamide; D008315:Malondialdehyde; D005486:Flavin Mononucleotide; D007290:Inosine Diphosphate; D002374:Catalase; D013482:Superoxide Dismutase