title: Bone substitute biomedical material of multi-(amino acid) copolymer: in vitro degradation and biocompatibility.
abstract: Degradable polymers with good mechanical strength as bone repair biomaterials have been paid more attention in biomedical application. In this study, a multi-(amino acid) copolymer consisting of 6-aminocaproic acid and five natural amino acids was prepared by a reaction of acid-catalyzed condensation. The results revealed that the copolymer could be slowly degradable in Tris-HCl solution, and lost its initial weight of 31.9 wt% after immersion for 12 weeks, and the changes of pH value of Tris-HCl solution were in range from 6.9 to 7.4 during soaking. The compressive strength of the copolymer decreased from 107 to 68 MPa after immersion for 12 weeks. The proliferation and differentiation of MG-63 cells on the copolymer significantly increased with time, and the cells with normal phenotype extended and spread well on the copolymer surfaces. When the copolymer was implanted in muscle and bone defects of femoral cortex of dogs for 12 weeks, the histological evaluation confirmed that the copolymer exhibited excellent biocompatibility and more effective osteogenesis in vivo. When implanted into cortical bone defects of dogs, the copolymer could be combined directly with the natural bone without fibrous capsule tissue between implants and host bone. The results indicated that the multi-(amino acid) copolymer with sufficient strength, good biocompatibility and osteoconductivity had clinical potential for load-bearing bone repair or substitution.
authors: School of Physical Science and Technology, Sichuan University, Chengdu 610064, People's Republic of China.
authors: Hong
authors: H
authors: Li
authors: Yonggang
authors: Y
authors: Yan
authors: Jie
authors: J
authors: Wei
authors: Jian
authors: J
authors: Ma
authors: Min
authors: M
authors: Gong
authors: Xiaoman
authors: X
authors: Luo
authors: Yunfei
authors: Y
authors: Zhang
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials; D018786:Bone Substitutes / Q000009:adverse effects / Q000737:chemistry*; D002460:Cell Line; D049109:Cell Proliferation; D019245:Compressive Strength; D004285:Dogs; D006863:Hydrogen-Ion Concentration; D008297:Male; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D018482:Muscle, Skeletal; D009135:Muscular Diseases / Q000209:etiology; D011108:Polymers / Q000737:chemistry*; D013499:Surface Properties; D015431:Weight Loss
chemical_list: D000596:Amino Acids; D001672:Biocompatible Materials; D018786:Bone Substitutes; D011108:Polymers