title: Nonalcoholic fatty liver disease: pharmacologic and surgical options.
abstract: The last decade has seen many studies examining the prevalence and natural history of NAFLD in the United States and it is clear that this disease is likely to be an important cause of liver-related morbidity in the future. Several pharmacologic therapies have shown some promise; currently, vitamin E and insulin-sensitizing agents such as pioglitazone can be considered in appropriate cases. Conservative measures to promote weight loss still have a role to play, but the obesity epidemic in the Western World has reached such proportions that bariatric surgery is proving to be an attractive option for patients with a BMI greater than 35 to 40 kg/m2. Well-designed prospective studies are required to ensure that all of these therapies are safe and effective in the long term. Newer agents will likely be investigated as the pathogenesis of NAFLD and fibrosis progression in NASH are further elucidated.
authors: Division of Internal Medicine, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, NY 10029, USA.
authors: Neil
authors: N
authors: Parikh
authors: Jawad
authors: J
authors: Ahmad
mesh_terms: D000924:Anticholesteremic Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D050110:Bariatric Surgery; D002756:Cholagogues and Choleretics / Q000627:therapeutic use; D005234:Fatty Liver / Q000150:complications / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008082:Lipotropic Agents / Q000627:therapeutic use; D016031:Liver Transplantation; D065626:Non-alcoholic Fatty Liver Disease; D009765:Obesity / Q000150:complications / Q000628:therapy; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use; D045162:Thiazolidinediones / Q000627:therapeutic use
chemical_list: D000924:Anticholesteremic Agents; D000975:Antioxidants; D002756:Cholagogues and Choleretics; D007004:Hypoglycemic Agents; D008082:Lipotropic Agents; D010726:Phosphodiesterase Inhibitors; D045162:Thiazolidinediones