title: Neoteric pharmacotherapeutic targets in fibromyalgia.
abstract: BACKGROUND
  Fibromyalgia is a debilitating, chronic pain disorder typically present with allodynia and hyperalgesia. Estimates from the USA suggest that fibromyalgia affects about 5% of women, and is the third most common rheumatic disorder after lower back pain and osteoarthritis. Recent research advances highlighted a role for aberrant central pain processing in fibromyalgia, and consistent with this, the first three drugs (pregabalin, duloxetine and milnacipran) approved by the FDA for fibromyalgia over the past 2 years have a predominantly central mode of action. Despite progress in understanding of fibromyalgia and the long-awaited introduction of three medications for treating it, fibromyalgia continues to pose a significantly unmet medical need, negatively affecting the lives of millions of individuals worldwide in all ethnic groups and all economic classes.
  
  
  METHODS
  Prevailing theories of pathogenesis of fibromyalgia, existing therapies and the potential of current research on novel targets.
  
  
  CONCLUSIONS
  Current research on novel sedative-hypnotics, anti-epileptic medications, various reuptake inhibitors, growth hormone agonists, canabinoid agonists, non-opiate analgesics and 5-HT3 antagonists offers hope for the the next generation of therapeutic options for fibromyalgia. With regards to the development of novel pharmacotherapies, there seem to be grounds for increased optimism regarding prospective treatments of the disorder.
authors: Panjab University, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study, Pharmacology Research Laboratory, Chandigarh-160014, India. dr_chopra_k@yahoo.com
authors: Kanwaljit
authors: K
authors: Chopra
authors: Anurag
authors: A
authors: Kuhad
authors: Vipin
authors: V
authors: Arora
mesh_terms: D000818:Animals; D003521:Cyclopropanes / Q000494:pharmacology / Q000627:therapeutic use; D017277:Drug Approval; D016503:Drug Delivery Systems; D015195:Drug Design; D000068736:Duloxetine Hydrochloride; D005260:Female; D005356:Fibromyalgia / Q000188:drug therapy* / Q000453:epidemiology / Q000503:physiopathology; D006801:Humans; D000078764:Milnacipran; D000069583:Pregabalin; D013876:Thiophenes / Q000494:pharmacology / Q000627:therapeutic use; D014481:United States / Q000453:epidemiology; D014486:United States Food and Drug Administration; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D003521:Cyclopropanes; D013876:Thiophenes; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid; D000068736:Duloxetine Hydrochloride; D000078764:Milnacipran