title: Stevens-Johnson syndrome associated with cytomegalovirus infection in a child with ependymoma.
abstract: BACKGROUND
  Stevens-Johnson syndrome is an uncommon, acute life-threatening disease characterized by extensive epidermal sloughing and mucositis. In childhood, as in adulthood, this condition is mostly related to drugs, in particular antibiotics. Only a few cases reported were firmly attributed to infectious agents, mainly Mycoplasma pneumonia but the causative role of infectious microorganisms seems particularly relevant in pediatric patients. The seriousness of this condition imposes a prompt recognition and the early withdrawal of the potential causative drugs or the institution of directed measures against infectious agents (depending on the suspected etiology), as well as a supportive and more specific therapy. Some treatments claim to halt the progression of skin detachment, but remain of unproven benefit due to the lack of prospective, well controlled, randomized clinical trials.
  
  
  METHODS
  We report a case of a 2-year-old boy admitted in our hospital for the treatment of an ependymoma of the posterior fossa, who developed a Stevens-Johnson syndrome associated most probably with a cytomegalovirus infection. He was successfully treated with high dose intravenous immunoglobulin and gancyclovir.
  
  
  CONCLUSIONS
  To the best of our knowledge, this is the first case of SJS associated with CMV infection.
authors: Department of Dermatology and Venereology, Hospital de São João, Porto, Portugal.
authors: Maria João
authors: MJ
authors: Cruz
authors: Alberto
authors: A
authors: Mota
authors: Teresa
authors: T
authors: Baudrier
authors: Maria João
authors: MJ
authors: Gil-da-Costa
authors: Filomena
authors: F
authors: Azevedo