title: Tumour in solitary kidney: laparoscopic partial nephrectomy vs laparoscopic cryoablation.
abstract: OBJECTIVE
  We compare perioperative, functional and intermediate-term oncological outcomes of laparoscopic partial nephrectomy (LPN) vs laparoscopic cryoablation (LCA) for small renal tumour in patients with a solitary kidney. A treatment algorithm is also proposed.
  
  
  METHODS
  Over a 10-year period (02/1998-09/2008), 78 patients with a small tumour in a functionally solitary kidney underwent LPN (n = 48) or LCA (n = 30). Baseline, perioperative, and follow-up data were collected prospectively and analyzed retrospectively.
  
  
  RESULTS
  Demographic data were similar between the LPN and LCA groups. Tumours were somewhat larger (3.2 vs 2.6 cm) in the LPN group. LPN was associated with greater blood loss (391 vs 162 mL; P = 0.003), and trended towards more post-operative complications (22.9% vs 6.7%; P = 0.07). By 3 months post-operative, eGFR decreased by 14.5% and 7.3% after LPN and LCA, respectively (P = 0.02). Post-operative temporary dialysis was required after 3 LPN (6.2% vs 0%, P = 0.16). Median follow-up time for LPN and LCA was 42.7 and 60.2 months, respectively. Local recurrence was detected in 4 (13.3%) LCA patients only (P = 0.02). Overall survival was comparable between LPN and LCA at 3 and 5 years, respectively (P = 0.74). The LPN group had superior cancer-specific and recurrence-free survival at 3 and 5 years compared to the LCA group (P < 0.05, for all comparisons).
  
  
  CONCLUSIONS
  Given adequate technical expertise, both LPN and LCA are viable nephron-sparing options for patients with tumour in a solitary kidney. Although LCA is technically easier and has superior functional outcomes, oncologic outcomes are superior after LPN.
authors: Section of Laparoscopic and Robotic Surgery, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH 44195, USA. Haberg2@ccf.org
authors: Georges-Pascal
authors: GP
authors: Haber
authors: Michael C
authors: MC
authors: Lee
authors: Sebastien
authors: S
authors: Crouzet
authors: Kazumi
authors: K
authors: Kamoi
authors: Inderbir S
authors: IS
authors: Gill
mesh_terms: D017115:Catheter Ablation / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D009367:Neoplasm Staging; D009392:Nephrectomy / Q000379:methods*; D011446:Prospective Studies; D012720:Severity of Illness Index; D015996:Survival Rate; D013997:Time Factors; D014481:United States / Q000453:epidemiology