title: Novel thiophenyl C-aryl glucoside SGLT2 inhibitors as potential antidiabetic agents.
abstract: Novel thiophene C-aryl glucoside SGLT2 inhibitors were designed and synthesized. Two different types of thiophene derivatives were readily prepared. Among the compounds tested, ethylphenyl at the distal ring 71p showed the best in vitro inhibitory activity in this series to date (IC(50)=4.47 nM) against SGLT2.
authors: Research Center, Green Cross Corporation, 303 Bojeong-Dong, Giheung-Gu, Yongin, Gyeonggi-Do 446-770, Republic of Korea.
authors: Suk Ho
authors: SH
authors: Lee
authors: Kwang-Seop
authors: KS
authors: Song
authors: Jong Yup
authors: JY
authors: Kim
authors: Misuk
authors: M
authors: Kang
authors: Jun Sung
authors: JS
authors: Lee
authors: Seung-Hwan
authors: SH
authors: Cho
authors: Hyun-Ju
authors: HJ
authors: Park
authors: Jeongmin
authors: J
authors: Kim
authors: Jinhwa
authors: J
authors: Lee
mesh_terms: D001559:Benzhydryl Compounds; D005960:Glucosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D051297:Sodium-Glucose Transporter 2 / Q000378:metabolism; D000077203:Sodium-Glucose Transporter 2 Inhibitors; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: C569062:(2R,3R,4S,5S,6R)-2-(5-chloro-4-(4-ethylbenzyl)thiophen-2-yl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol; D001559:Benzhydryl Compounds; D005960:Glucosides; D007004:Hypoglycemic Agents; D051297:Sodium-Glucose Transporter 2; D000077203:Sodium-Glucose Transporter 2 Inhibitors; D013876:Thiophenes; C529054:dapagliflozin