title: RosettaRemodel: a generalized framework for flexible backbone protein design.
abstract: We describe RosettaRemodel, a generalized framework for flexible protein design that provides a versatile and convenient interface to the Rosetta modeling suite. RosettaRemodel employs a unified interface, called a blueprint, which allows detailed control over many aspects of flexible backbone protein design calculations. RosettaRemodel allows the construction and elaboration of customized protocols for a wide range of design problems ranging from loop insertion and deletion, disulfide engineering, domain assembly, loop remodeling, motif grafting, symmetrical units, to de novo structure modeling.
authors: Department of Biochemistry, University of Washington, Seattle, Washington, United States of America.
authors: Po-Ssu
authors: PS
authors: Huang
authors: Yih-En Andrew
authors: YE
authors: Ban
authors: Florian
authors: F
authors: Richter
authors: Ingemar
authors: I
authors: Andre
authors: Robert
authors: R
authors: Vernon
authors: William R
authors: WR
authors: Schief
authors: David
authors: D
authors: Baker
mesh_terms: D016000:Cluster Analysis; D019295:Computational Biology / Q000379:methods*; D004220:Disulfides / Q000378:metabolism; D008958:Models, Molecular; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*; D020539:Sequence Analysis, Protein; D012984:Software
chemical_list: D004220:Disulfides; D011506:Proteins