title: Oxytocin receptor gene (OXTR) is related to psychological resources.
abstract: Psychological resources--optimism, mastery, and self-esteem--buffer the deleterious effects of stress and are predictors of neurophysiological and psychological health-related outcomes. These resources have been shown to be highly heritable, yet the genetic basis for this heritability remains unknown. Here, we report a link between the oxytocin receptor (OXTR) SNP rs53576 and psychological resources, such that carriers of the "A" allele have lower levels of optimism, mastery, and self-esteem, relative to G/G homozygotes. OXTR was also associated with depressive symptomatology. Mediation analysis indicates that the effects of OXTR on depressive symptoms may be largely mediated by the influence of OXTR on psychological resources.
authors: Department of Psychology, University of California, Los Angeles, CA 90095, USA.
authors: Shimon
authors: S
authors: Saphire-Bernstein
authors: Baldwin M
authors: BM
authors: Way
authors: Heejung S
authors: HS
authors: Kim
authors: David K
authors: DK
authors: Sherman
authors: Shelley E
authors: SE
authors: Taylor
mesh_terms: D000293:Adolescent; D000328:Adult; D003863:Depression / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008606:Mental Processes; D008960:Models, Psychological; D018045:Receptors, Oxytocin / Q000235:genetics*; D055815:Young Adult
chemical_list: D018045:Receptors, Oxytocin