title: [Primary mediastinal (thymic) large B-cell lymphoma: review of the literature and author's own data].
abstract: OBJECTIVE
  To study morphoimmunological and clinical features of primary mediastinal large B-cell lymphoma (PMLBCL).
  
  
  METHODS
  We analysed the results of biopsy material study and treatment of 86 PMLBCL patients, effects of different factors on the disease prognosis, efficacy of some therapeutic programs and overall therapeutic efficacy.
  
  
  RESULTS
  PMLBCL manifests mainly with massive lesions of anterior upper mediastinum with involvement of adjacent organs and tissues, absence of bone marrow involvement, frequent affection of CNS. Many primary patients have resistance to treatment, sensitive patients have no late recurrences.
  
  
  CONCLUSIONS
  PMLBCL is an independent extranodal variant of non-Hodgkin's lymphoma with special clinical and morphoimmunological characteristics. Criteria are proposed for differential diagnosis of different variants of PMLBCL. New approaches to PMLBSL patients' management are outlined.
authors: M Iu
authors: MIu
authors: Kichigina
authors: G S
authors: GS
authors: Tumian
authors: A M
authors: AM
authors: Kovrigina
authors: O P
authors: OP
authors: Trofimova
authors: V B
authors: VB
authors: Larionova
authors: A A
authors: AA
authors: Chekan
authors: D A
authors: DA
authors: Bykov
authors: D Sh
authors: DSh
authors: Osmanov
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D008297:Male; D008479:Mediastinal Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D008875:Middle Aged; D013953:Thymus Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D055815:Young Adult