title: Progressive growth in epibulbar complex choristomas: report of 2 cases and review of literature.
abstract: OBJECTIVE
  To report 2 patients with progressive complex choristomas and to review the literature on this subject.
  
  
  METHODS
  Interventional case reports.
  
  
  METHODS
  Clinical and pathologic correlation was performed on 2 patients with progressive epibulbar choristomas. PubMed database was searched to identify all the previously reported cases of progressive epibulbar choristomas (using key words choristoma, dermoid, growth, progression, and evolution).
  
  
  RESULTS
  Growth of the epibulbar choristomas was noted in infancy in 1 patient with oculoectodermal syndrome and in puberty in another otherwise healthy patient. Both lesions were identified histopathologically as complex choristomas. In addition to the characteristic choristomatous tissues, both lesions demonstrated increased vascularity, inflammatory infiltrate, and fibroblast proliferation within myxomatous stroma. Review of the literature identified 4 patients with progressive complex choristomas, 1 of whom demonstrated histopathologic findings similar to those of the 2 cases reported here.
  
  
  CONCLUSIONS
  Epibulbar choristomas rarely enlarge, likely secondary to reactive changes within the tissue manifested by increased vascularity, inflammatory cell infiltration, and fibroblast proliferation with deposition of myxomatous stroma.
authors: Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, NY 10003, USA.
authors: Valerie
authors: V
authors: Trubnik
authors: Ryan
authors: R
authors: Conley
authors: David C
authors: DC
authors: Ritterband
authors: Ira
authors: I
authors: Udell
authors: Glenn
authors: G
authors: Thompson
authors: Carolyn
authors: C
authors: Shih
authors: Steven A
authors: SA
authors: McCormick
authors: Tatyana
authors: T
authors: Milman
mesh_terms: D000273:Adipose Tissue; D000293:Adolescent; D002828:Choristoma / Q000473:pathology* / Q000601:surgery; D003094:Collagen; D005123:Eye; D006801:Humans; D007231:Infant, Newborn; D007765:Lacrimal Apparatus; D008297:Male; D009130:Muscle, Smooth; D009916:Orbital Diseases / Q000473:pathology* / Q000601:surgery
chemical_list: D003094:Collagen