title: Synthesis and characterization of novel amphiphilic copolymer stearic acid-coupled F127 nanoparticles for nano-technology based drug delivery system.
abstract: Pluronic, F127, amphiphilic block copolymers, are used for several applications, including drug delivery systems. The critical micelle concentration (CMC) of F127 is about 0.26-0.8 wt% so that the utility of F127 in nano-technology based drug delivery system is limited since the nano-sized micelles could dissociate upon dilution. Herein, stearic acid (SA) was simply coupled to F127 between the carboxyl group of SA and the hydroxyl group of F127, which formed a novel copolymer named as SA-coupled F127, with significantly lower CMC. Above the CMC 6.9 × 10(-5)wt%, SA-coupled F127 self-assembled stable nanoparticles with Zeta potential -36 mV. Doxorubicin (DOX)-loaded nanoparticles were made, with drug loading (DL) 5.7 wt% and Zeta potential -36 to -39 mV, and the nanoparticles exhibited distinct shape with the size distribution from 20 to 50 nm. DOX-loaded nanoparticles were relatively stable and exhibited DOX dependant cytotoxicity toward MCF-7 cells in vitro. These results suggest that SA-coupled F127 potentially could be applied as a nano-technology based drug delivery method.
authors: Southeast University, School of Chemistry and Chemical Engineering, Nanjing 210000, China.
authors: Qihe
authors: Q
authors: Gao
authors: Qing
authors: Q
authors: Liang
authors: Fei
authors: F
authors: Yu
authors: Jian
authors: J
authors: Xu
authors: Qihua
authors: Q
authors: Zhao
authors: Baiwang
authors: B
authors: Sun
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D011108:Polymers / Q000737:chemistry*; D013229:Stearic Acids / Q000737:chemistry*
chemical_list: D011108:Polymers; D013229:Stearic Acids; C031183:stearic acid