title: Effect of salicylate on potassium currents in inner hair cells isolated from guinea-pig cochlea.
abstract: Although salicylate is one of the most widely used nonsteroidal anti-inflammatory drugs, it causes moderate hearing loss and tinnitus at high-dose levels. In the present study, salicylate effects on the K currents in inner hair cells were examined. Salicylate reversibly reduced the outward K currents (I(K,f)), but did not affect the inward current (I(K,n)). Salicylate blocked the outward K currents in a concentration-dependent manner according to Hill equation with a half-blocking concentration of 1.66mM, and the Hill coefficient of 1.86.
authors: Department of Otolaryngology, Graduate School of Medical Sciences, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higasi-Ku, Fukuoka 812-8582, Japan. kimitaka@qent.med.kyushu-u.ac.jp
authors: Takashi
authors: T
authors: Kimitsuki
authors: Mitsuru
authors: M
authors: Ohashi
authors: Yoshihiro
authors: Y
authors: Umeno
authors: Takamasa
authors: T
authors: Yoshida
authors: Noritaka
authors: N
authors: Komune
authors: Teppei
authors: T
authors: Noda
authors: Shizuo
authors: S
authors: Komune
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D003051:Cochlea / Q000187:drug effects* / Q000502:physiology; D006168:Guinea Pigs; D006199:Hair Cells, Auditory, Inner / Q000187:drug effects* / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D018408:Patch-Clamp Techniques; D015221:Potassium Channels / Q000187:drug effects* / Q000502:physiology; D012980:Sodium Salicylate / Q000494:pharmacology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D015221:Potassium Channels; D012980:Sodium Salicylate