title: Anti-cancer activity of a novel palladium(II) complex on human breast cancer cells in vitro and in vivo.
abstract: Anti-cancer effects of a newly-synthesized palladium(II) complex, [Pd(sac)(terpy)](sac)·4H(2)O (sac = saccharinate, and terpy = 2,2':6',2''-terpyridine), were tested against human breast cancer cell lines, MCF-7 and MDA-MB-231. The Pd complex had a strong anti-growth effect in a dose- and time-dependent manner in vitro. This effect was also confirmed by the experiment performed on Balb/c mice in vivo. The IC(50) values were 0.09 μM for MDA-MB-231 and 3.05 μM for MCF-7. It was also very effective in disrupting the formation of MDA-MB-231 tubules on matrigel, indicative of a putative anti-invasive activity. It induced apoptosis via the cell death genes of DR4 and DR5. In conclusion, this newly-synthesized Pd (II) complex represents a potentially active novel drug for the breast cancer treatment.
authors: Uludag University, Medical School, Department of Medical Biochemistry, Bursa, Turkey. eulukaya@uludag.edu.tr
authors: Engin
authors: E
authors: Ulukaya
authors: Ferda
authors: F
authors: Ari
authors: Konstantinos
authors: K
authors: Dimas
authors: Elif Ilkay
authors: EI
authors: Ikitimur
authors: Emel
authors: E
authors: Guney
authors: Veysel T
authors: VT
authors: Yilmaz
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D010165:Palladium / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D010165:Palladium