title: [Vasoplegic syndrome and its treatment with vasopressin during cardiac surgery with cardiopulmonary bypass].
abstract: Cardiac surgery with cardiopulmonary bypass is associated with systemic inflammatory response. In some cases this clinical condition is characterized by severe hypotension due to low systemic vascular resistance during and after cardiopulmonary bypass. A few of these cases do not respond to volume or catecholamines. This condition is known as vasoplegic syndrome. Its etiology is not fully understood today and carries associated morbidity and mortality In this syndrome, vasopressin levels are reduced, as in septic and hypovolemic shock. Supplementary vasopressin improves blood pressure and might be considered as an alternative treatment. Several reports have shown benefits when used alone or in combination with catecholamines. However, further studies are necessary to find the most appropriate use of the drug for vasoplegic syndrome.
authors: División de Anestesiología, Pontificia Universidad Católica de Chile, Santiago, Chile. macarena@gilbert.net
authors: Macarena
authors: M
authors: Gilbert
authors: Guillermo
authors: G
authors: Lema
mesh_terms: D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D006801:Humans; D011183:Postoperative Complications; D012307:Risk Factors; D013577:Syndrome; D014662:Vasoconstrictor Agents / Q000627:therapeutic use*; D056987:Vasoplegia / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D014667:Vasopressins / Q000627:therapeutic use*
chemical_list: D014662:Vasoconstrictor Agents; D014667:Vasopressins