title: Association between preterm delivery and subsequent C-reactive protein: a retrospective cohort study.
abstract: OBJECTIVE
  We sought to determine whether giving birth preterm is associated with raised maternal C-reactive protein (CRP) in later life and whether the association is specific to indicated or spontaneous delivery.
  
  
  METHODS
  This was a Scotland-wide retrospective cohort study of 1124 women who had a first pregnancy resulting in a singleton, liveborn infant delivered between 24-43 weeks' gestation. Linear regression analysis was used to examine the association between preterm delivery and subsequent CRP concentration.
  
  
  RESULTS
  The difference in CRP between women who delivered term and preterm was nonsignificant on univariate analysis (beta coefficient 0.04, P = .18) but was statistically significant following adjustment for potential confounders (beta coefficient 0.05, P < .05). On subgroup analysis the association was specific to women who had had indicated preterm delivery (unadjusted beta coefficient 0.09, P < .01; adjusted beta coefficient 0.09, P < .01).
  
  
  CONCLUSIONS
  Women who undergo indicated preterm delivery are at increased risk of raised CRP in later life.
authors: British Heart Foundation Cardiovascular Research Center, University of Glasgow, Glasgow, Scotland, United Kingdom.
authors: Claire E
authors: CE
authors: Hastie
authors: Gordon C S
authors: GC
authors: Smith
authors: Daniel F
authors: DF
authors: Mackay
authors: Jill P
authors: JP
authors: Pell
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology; D000293:Adolescent; D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D015331:Cohort Studies; D036861:Delivery, Obstetric / Q000706:statistics & numerical data; D005260:Female; D006306:Health Surveys / Q000706:statistics & numerical data; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D007249:Inflammation / Q000097:blood* / Q000453:epidemiology* / Q000276:immunology; D008875:Middle Aged; D011225:Pre-Eclampsia / Q000453:epidemiology; D011247:Pregnancy; D047928:Premature Birth / Q000097:blood* / Q000453:epidemiology* / Q000276:immunology; D011297:Prenatal Exposure Delayed Effects / Q000097:blood / Q000453:epidemiology / Q000276:immunology; D012189:Retrospective Studies; D012307:Risk Factors; D012606:Scotland / Q000453:epidemiology; D055815:Young Adult
chemical_list: D002097:C-Reactive Protein