title: Circulating tumor cell isolation and diagnostics: toward routine clinical use.
abstract: From February 7-11, 2011, the multidisciplinary Lorentz Workshop Circulating Tumor Cell (CTC) Isolation and Diagnostics: Toward Routine Clinical Use was held in Leiden (The Netherlands) to discuss progress and define challenges and potential solutions for development of clinically useful circulating tumor cell (CTC) diagnostics. CTCs, captured as "liquid biopsy" from blood, for counting and characterization using pathology and molecular assays, are expected to replace metastatic tissue biopsies to be used to predict drug response and resistance and to monitor therapy response and cancer recurrence. CTCs are highly heterogeneous; therefore, cancer type-specific isolation technologies, as well as complex clinical interpretation software, are required.
authors: Philips Research, Eindhoven, The Netherlands. anja.van.de.stolpe@philips.com
authors: Anja
authors: A
authors: van de Stolpe
authors: Klaus
authors: K
authors: Pantel
authors: Stefan
authors: S
authors: Sleijfer
authors: Leon W
authors: LW
authors: Terstappen
authors: Jaap M J
authors: JM
authors: den Toonder
mesh_terms: D006801:Humans; D009369:Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000473:pathology; D009360:Neoplastic Cells, Circulating / Q000473:pathology*