title: Exploring the potential of the β-thiolactones in bioorganic chemistry.
abstract: A series of novel peptide-based β-thiolactones were synthesized and assayed for cytotoxicity against several human cancer cell lines, where they showed greater activity than the corresponding β-lactones and β-lactams. Several of the β-thiolactones prepared showed strong inhibitory activity in vitro against human cathepsins B and L.
authors: Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, 1 Avenue de la Terrasse, 91190, Gif-sur-Yvette, France.
authors: Sylvain
authors: S
authors: Aubry
authors: Kaname
authors: K
authors: Sasaki
authors: Laure
authors: L
authors: Eloy
authors: Geneviève
authors: G
authors: Aubert
authors: Pascal
authors: P
authors: Retailleau
authors: Thierry
authors: T
authors: Cresteil
authors: David
authors: D
authors: Crich
mesh_terms: D007783:Lactones / Q000737:chemistry*; D015394:Molecular Structure; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D007783:Lactones; D013438:Sulfhydryl Compounds