title: Review: milk fat globule-EGF factor 8 expression, function and plausible signal transduction in resolving inflammation.
abstract: Although the cloning and molecular characterization of MFG-E8 was first reported in the early 90s, breakthrough on MFG-E8 research came into light when it was explored as an outstanding factor for phagocytosis of apoptotic cells by professional macrophages in 2002. Since then numerous studies have been performed on MFG-E8 not only to demonstrate the role of phagocytic clearance of apoptotic cells, but also to focus on a wide range of aspects, even emphasizing on a direct link to innate-immune systems. In terms of its role as therapeutic potentials, our group, as well as others, has shown MFG-E8 to be an essential factor in attenuating inflammation and improving prognosis in several animal models of life threatening diseases. Considering these versatile functions of MFG-E8, several in vitro and in vivo studies were embarked on to explore the mechanistic pathways exerted by MFG-E8 during inflammation. With the relevant cumulative findings, herein we reviewed the potential roles of MFG-E8 in pathophysiological conditions by highlighting its plausible signal-transduction mechanisms.
authors: Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, 350 Community Dr, Manhasset, NY 11030, USA.
authors: Monowar
authors: M
authors: Aziz
authors: Asha
authors: A
authors: Jacob
authors: Akihisa
authors: A
authors: Matsuda
authors: Ping
authors: P
authors: Wang
mesh_terms: D000818:Animals; D000954:Antigens, Surface / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000494:pharmacology; D017209:Apoptosis / Q000276:immunology; D002460:Cell Line; D006017:Glycolipids / Q000737:chemistry*; D006023:Glycoproteins / Q000737:chemistry*; D024243:HMGB1 Protein / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D039302:Integrin alphaVbeta3 / Q000276:immunology / Q000378:metabolism; D066292:Lipid Droplets; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008894:Milk Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000494:pharmacology; D016328:NF-kappa B / Q000276:immunology / Q000378:metabolism; D010587:Phagocytosis / Q000187:drug effects* / Q000276:immunology; D010718:Phosphatidylserines / Q000378:metabolism; D051381:Rats; D050796:STAT3 Transcription Factor / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology*; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins / Q000276:immunology / Q000378:metabolism; D051197:Toll-Like Receptor 4 / Q000276:immunology / Q000378:metabolism
chemical_list: D000954:Antigens, Surface; D006017:Glycolipids; D006023:Glycoproteins; D024243:HMGB1 Protein; D039302:Integrin alphaVbeta3; C098942:MFGE8 protein, human; D008894:Milk Proteins; D016328:NF-kappa B; D010718:Phosphatidylserines; C106644:SOCS3 protein, human; D050796:STAT3 Transcription Factor; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4; C110367:milk fat globule