title: Structure-based drug design of a new chemical class of small molecules active against influenza A nucleoprotein in vitro and in vivo.
abstract: We report preliminary results and a summary of a bottom-up approach to identify new, active, nontoxic, small-molecule antivirals designed to have а novel mechanism of action. We employed the procedure to identify 3-mercapto-1,2,4-triazoles derivatives as potential NP inhibitors in silico and subsequently demonstrated the in vitro efficacy of the molecules against various strains of the influenza A virus. The most efficacious compounds were successfully tested in an in vivo influenza challenge experiment.
authors: Chief Scientific Officer, Quantum Pharmaceuticals; Pharmacology, Biotechnology, Molecular biology, Molecular oncology; Researcher, Quantum Pharmaceuticals Moscow; Quantum Pharmaceuticals, Researcher, Software Developer and CEO, Quantum Pharmaceticals Moscow.
authors: Peter
authors: P
authors: Fedichev
authors: Roman
authors: R
authors: Timakhov
authors: Tim
authors: T
authors: Pyrkov
authors: Evgeny
authors: E
authors: Getmantsev
authors: Andrey
authors: A
authors: Vinnik