title: Cross talk among TGF-β signaling pathways, integrins, and the extracellular matrix.
abstract: The growth factor TGF-β is secreted in a latent complex consisting of three proteins: TGF-β, an inhibitor (latency-associated protein, LAP, which is derived from the TGF-β propeptide) and an ECM-binding protein (one of the latent TGF-β binding proteins, or LTBPs). LTBPs interact with fibrillins and other ECM components and thus function to localize latent TGF-β in the ECM. LAP contains an integrin-binding site (RGD), and several RGD-binding integrins are able to activate latent TGF-β through binding this site. Mutant mice defective in integrin-mediated activators, and humans and mice with fibrillin gene mutations, show the critical role of ECM and integrins in regulating TGF-β signaling.
authors: Department of Medicine, New York University, New York, New York 10016, USA. john.munger@nyumc.org
authors: John S
authors: JS
authors: Munger
authors: Dean
authors: D
authors: Sheppard
mesh_terms: D000818:Animals; D005109:Extracellular Matrix / Q000378:metabolism*; D000071837:Fibrillins; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D053779:Latent TGF-beta Binding Proteins / Q000235:genetics / Q000378:metabolism; D008382:Marfan Syndrome / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008840:Microfilament Proteins / Q000378:metabolism; D008954:Models, Biological; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000378:metabolism*
chemical_list: D000071837:Fibrillins; D016023:Integrins; D053779:Latent TGF-beta Binding Proteins; D008840:Microfilament Proteins; D016212:Transforming Growth Factor beta