title: Increased longevity of some C. elegans mitochondrial mutants explained by activation of an alternative energy-producing pathway.
abstract: The Caenorhabditis elegans misc-1 gene encodes a mitochondrial carrier with a role in oxidative stress response. The knock-out mutant has no lifespan phenotype and fails to upregulate the gei-7-mediated glyoxylate shunt, an extra-mitochondrial pathway of energy production. We show that gei-7 is required for the longevity of the mitochondrial mutant clk-1. Our data suggest that only mitochondrial mutants that upregulate gei-7 can achieve longevity.
authors: Department of Medical Genetics, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada. mgallo@msl.ubc.ca
authors: Marco
authors: M
authors: Gallo
authors: Donha
authors: D
authors: Park
authors: Donald L
authors: DL
authors: Riddle
mesh_terms: D000818:Animals; D027321:Anion Transport Proteins / Q000235:genetics / Q000378:metabolism; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism; D004734:Energy Metabolism / Q000235:genetics; D055785:Gene Knockdown Techniques; D055786:Gene Knockout Techniques; D017238:Genes, Helminth; D050259:Genes, Mitochondrial; D008136:Longevity / Q000235:genetics* / Q000502:physiology*; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism; D024101:Mitochondrial Proteins; D009154:Mutation; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D027321:Anion Transport Proteins; D029742:Caenorhabditis elegans Proteins; C559122:MISC-1 protein, C elegans; D024101:Mitochondrial Proteins; D017382:Reactive Oxygen Species