title: Effect of nasal mometasone furoate on the nasal and nasopharyngeal flora.
abstract: OBJECTIVE
  Mometasone furoate (MF) is one of the commonly used topical steroids, particularly for patients with allergic rhinitis. However, its effect on the colonization of bacteria that may cause superinfections by suppressing the local immunity is not known. Thus, we investigated the effect of MF use on the nasal and nasopharyngeal microbial flora.
  
  
  METHODS
  Swab samples were taken from 35 patients who required MF monotherapy, just before and after one month of the treatment. Samples were maintained in Stuart's medium. Each swab was transferred to 1ml of a sterile saline solution, then into the standard agar. After incubation under 5% carbon dioxide at 37°C, colony number was detected per ml.
  
  
  RESULTS
  Colony counts of nasal or nasopharyngeal microbial flora did not show any statistically significant alteration with one month use of MF. However, an increase in potential pathogens as well as normal flora bacteria was determined in five of the patients and six patients acquired new nasopharyngeal potential pathogens, mostly Moraxella catarrhalis, Pseudomonas aeruginosa and Staphylococcus aureus, following the use of MF.
  
  
  CONCLUSIONS
  The use of MF for one month did not statistically significantly change the nasal and nasopharyngeal flora. This study indicates that MF could be increase the colonization of the potential pathogens in some of the patients at the subclinical level particularly in the nasopharyngeal area.
authors: Bezmialem Vakıf University, Medical Faculty, Department of Otorhinolaryngology and Head and Neck Surgery, Istanbul, Turkey.
authors: Fadlullah
authors: F
authors: Aksoy
authors: Hasan
authors: H
authors: Demirhan
authors: Gülüm İvgin
authors: Gİ
authors: Bayraktar
authors: Yavuz Selim
authors: YS
authors: Yıldırım
authors: Orhan
authors: O
authors: Ozturan
authors: Nevriye
authors: N
authors: Gönüllü
authors: Burcu
authors: B
authors: Sapmaz
mesh_terms: D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D015169:Colony Count, Microbial; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D000068656:Mometasone Furoate; D009297:Nasal Mucosa / Q000187:drug effects* / Q000382:microbiology*; D009305:Nasopharynx / Q000187:drug effects* / Q000382:microbiology*; D011244:Pregnadienediols / Q000494:pharmacology*; D012220:Rhinitis / Q000382:microbiology; D012852:Sinusitis / Q000382:microbiology; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D011244:Pregnadienediols; D000068656:Mometasone Furoate