title: The efficacy of multimodal high-volume wound infiltration in primary total hip replacement.
abstract: Multimodal wound infiltration with local anesthetics, adrenaline, and nonsteroidal anti-inflammatory agents can lower the opiate intake, reduce the length of stay, and enhance early mobilization after total hip arthroplasty (THA). A retrospective review of 204 patients undergoing primary THA was undertaken. One hundred two patients had their wounds infiltrated with ropivacaine, adrenaline, and ketorolac by the operating surgeon intraoperatively. Subsequently, a 19-gauge wound catheter was inserted percutaneously into the hip joint. Patients received 2 further top-up doses of 20 mL of ropivacaine (7.5 mg/mL) at 10 and 20 hours postoperatively. These patients were compared to a control group of 102 patients who received no local infiltration. Both groups were comparable in terms of body mass index and age. Opiate consumption in the first 48 hours after surgery and length of hospital stay were recorded. The mean consumption of morphine in the treatment group was 42.3 mg (standard deviation [SD], 31.2 mg) compared to 60.9 mg (SD, 33.8 mg) in the control group (P<.0001). The mean length of stay was significantly reduced from 5.2 days (SD, 1.6 days) in the control group to 4 days (SD, 1.3 days) in the treatment group (P<.0001). The time needed by the patients to walk for 3 meters after surgery was significantly reduced in the treatment group (median, 25 vs 46.1 hours; interquartile range, 20.7- 45.1 vs 27.2- 50.9; P<.0001). This is the largest series to demonstrate that a multimodal perioperative wound infiltration technique in primary THA surgery leads to early attainment of immediate postoperative rehabilitation milestones and reduced length of stay along with reduction in postoperative opiate consumption.
authors: Epsom General Hospital, London, United Kingdom.
authors: Purnajyoti
authors: P
authors: Banerjee
authors: Christopher
authors: C
authors: McLean
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000577:Amides / Q000008:administration & dosage*; D000701:Analgesics, Opioid / Q000008:administration & dosage; D000779:Anesthetics, Local / Q000008:administration & dosage*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects / Q000379:methods*; D004359:Drug Therapy, Combination; D004837:Epinephrine / Q000008:administration & dosage; D005260:Female; D006621:Hip Joint / Q000187:drug effects / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D007270:Injections, Intra-Articular; D007432:Intraoperative Period; D020910:Ketorolac / Q000008:administration & dosage; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D011183:Postoperative Complications; D016059:Range of Motion, Articular; D012189:Retrospective Studies; D000077212:Ropivacaine; D055815:Young Adult
chemical_list: D000577:Amides; D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000077212:Ropivacaine; D004837:Epinephrine; D020910:Ketorolac