title: Asymmetric construction of trifluoromethylated pyrrolidines via Cu(I)-catalyzed 1,3-dipolar cycloaddition of azomethine ylides with 4,4,4-trifluorocrotonates.
abstract: Trifluoromethylated pyrrolidines have been synthesized via catalytic asymmetric 1,3-dipolar cycloaddition with excellent stereoselectivity for the first time. Epimerization of the endo-pyrrolidines obtained from cis-4,4,4-trifluorocrotonate into the exo-pyrrolidines was also revealed.
authors: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China.
authors: Qing-Hua
authors: QH
authors: Li
authors: Min-Chao
authors: MC
authors: Tong
authors: Jun
authors: J
authors: Li
authors: Hai-Yan
authors: HY
authors: Tao
authors: Chun-Jiang
authors: CJ
authors: Wang
mesh_terms: D001391:Azo Compounds / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003437:Crotonates / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D011759:Pyrrolidines / Q000737:chemistry*; D013882:Thiosemicarbazones / Q000737:chemistry*
chemical_list: D001391:Azo Compounds; D003437:Crotonates; D011759:Pyrrolidines; D013882:Thiosemicarbazones; C512188:azomethine; D003300:Copper