title: Gastric cancer: biology and clinical manifestations in Israel.
abstract: BACKGROUND
  Gastric cancer (GC) in Israel remains incompletely characterized. The aim of this study was to define the clinical and pathological characteristics of GC in Israel and to compare them to the general Western population.
  
  
  METHODS
  This is a retrospective analysis of 461 consecutive GC patients treated at a single institution between 1995 and 2007. Epidemiological and clinical-pathological data were retrieved from the patients' medical files and the institutional electronic database and analyzed using standard statistical methods.
  
  
  RESULTS
  Epidemiology, clinical manifestations, histopathological findings, clinical course, and prognostic factors for disease outcome were all similar to those reported in the Western literature. Findings unique to the Israeli population included: (1) rarity of GC-associated risk factors; (2) increased GC incidence in Ashkenazi Jews; (3) high incidence of second primary malignancy and family history of cancer; and (4) no dominancy of proximal GCs.
  
  
  CONCLUSIONS
  There do not appear to be any major differences in the biology or clinical manifestations of GC in Israel. Western recommendations for diagnosis and treatment of GC may therefore be applied to the Israeli patient population.
authors: Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors: Ayelet
authors: A
authors: Dreznik
authors: Ofer
authors: O
authors: Purim
authors: Efraim
authors: E
authors: Idelevich
authors: Yulia
authors: Y
authors: Kundel
authors: Jaqueline
authors: J
authors: Sulkes
authors: Aaron
authors: A
authors: Sulkes
authors: Baruch
authors: B
authors: Brenner
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D005743:Gastrectomy / Q000706:statistics & numerical data; D017219:Gastric Outlet Obstruction / Q000453:epidemiology; D020022:Genetic Predisposition to Disease; D006801:Humans; D007557:Israel / Q000453:epidemiology; D007585:Jews; D008039:Linitis Plastica / Q000453:epidemiology; D008197:Lymph Node Excision / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D016609:Neoplasms, Second Primary; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy; D055815:Young Adult