title: Outcome of surgical complications following simultaneous pancreas-kidney transplantation.
abstract: BACKGROUND
  Simultaneous pancreas-kidney (SPK) transplantation carries a higher risk of surgical complications than kidney transplantation alone. We aimed to establish the incidence of surgical complications after SPK transplantation and determine the effect on graft and patient survival.
  
  
  METHODS
  Outcomes of all SPK transplants performed at our centre were compared between patients who experienced a surgical complication (SC group) and those who did not (NSC group).
  
  
  RESULTS
  Our centre performed 193 SPK transplants in a 15-year period; 44 patients (23%) experienced a surgical complication. One-year and 5-year pancreatic graft survival was 89 and 80%, respectively; this was lower in the SC group. There was no significant difference in patient or kidney graft survival between the SC and NSC groups at 5 years (92 and 83%, respectively.)
  
  
  CONCLUSIONS
  Surgical complications following SPK transplantation can cause significant morbidity and adversely affect pancreas graft survival, but do not affect long-term kidney or patient survival.
authors: Department of Transplantation, Guys and St Thomas’ NHS Foundation Trust, London, UK.
authors: Neal
authors: N
authors: Banga
authors: Vassilis G
authors: VG
authors: Hadjianastassiou
authors: Nizam
authors: N
authors: Mamode
authors: Francis
authors: F
authors: Calder
authors: Jonathon
authors: J
authors: Olsburgh
authors: Martin
authors: M
authors: Drage
authors: Cinzia
authors: C
authors: Sammartino
authors: Geoff
authors: G
authors: Koffman
authors: John
authors: J
authors: Taylor
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000453:epidemiology* / Q000209:etiology; D006085:Graft Survival; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation / Q000009:adverse effects* / Q000401:mortality; D011183:Postoperative Complications; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D006113:United Kingdom / Q000453:epidemiology; D055815:Young Adult