title: [First results of Ph-negative acute lymphoblastic leukemia therapy of adults according to the protocol of Research Group of Russian Hematological Centers ALL-2009].
abstract: OBJECTIVE
  To review results of 2-year experience in execution of the protocol on the treatment of adult acute Ph-negative lymphoblastic leukemia ALL-2009.
  
  
  METHODS
  Of 111 patients registered in the study from November 2008 to December 2010 the analysis covered 96 patients from 23 hematological centers in 18 towns of the RF.
  
  
  RESULTS
  Treatment according to the Protocol ALL-2009 resulted in achievement of a complete remission in 91.2% patients with low early lethality of 5.5%. Postremission lethality fell to 3.7% versus previous studies (22%). Overall 2-year survival and recurrence-free survival reached 77.6 and 78.4%, respectively. Detection of any chromosomic aberrations significantly affected recurrence-free survival: 74 vs 100% in patients with normal karyotype.
  
  
  CONCLUSIONS
  Protocol All-2009 demonstrates high efficacy in moderate toxicity and good reproducibility in any hematologic center.
authors: E N
authors: EN
authors: Parovichnikova
authors: G A
authors: GA
authors: Kliasova
authors: V G
authors: VG
authors: Isaev
authors: A N
authors: AN
authors: Sokolov
authors: A V
authors: AV
authors: Kokhno
authors: V V
authors: VV
authors: Troitskaia
authors: E V
authors: EV
authors: Mavrina
authors: E E
authors: EE
authors: Khodunova
authors: E N
authors: EN
authors: Ustinova
authors: E O
authors: EO
authors: Gribanova
authors: S K
authors: SK
authors: Kravchenko
authors: V V
authors: VV
authors: Ryzhko
authors: T S
authors: TS
authors: Kaporskaia
authors: O Iu
authors: OIu
authors: Baranova
authors: S N
authors: SN
authors: Bondarenkko
authors: A S
authors: AS
authors: Nizametdinova
authors: E V
authors: EV
authors: Kondakova
authors: T V
authors: TV
authors: Ryl'tsova
authors: A N
authors: AN
authors: Alufer'eva
authors: O S
authors: OS
authors: Samoĭlova
authors: O P
authors: OP
authors: Skamorina
authors: L V
authors: LV
authors: Gavrilova
authors: A S
authors: AS
authors: Pristupa
authors: N A
authors: NA
authors: Vopilina
authors: T S
authors: TS
authors: Konstantinova
authors: I V
authors: IV
authors: Kriuchkova
authors: L V
authors: LV
authors: Anchukova
authors: T S
authors: TS
authors: Tikunova
authors: K D
authors: KD
authors: Kaplanov
authors: V A
authors: VA
authors: Lapin
authors: V A
authors: VA
authors: Tumakov
authors: M N
authors: MN
authors: Kozmina
authors: S A
authors: SA
authors: Chernysh
authors: E I
authors: EI
authors: Podol'tseva
authors: S M
authors: SM
authors: Kulikov
authors: Iu R
authors: IuR
authors: Davidian
authors: V G
authors: VG
authors: Savchenko
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010677:Philadelphia Chromosome; D010865:Pilot Projects; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality; D012008:Recurrence; D012074:Remission Induction; D055815:Young Adult