title: Synthesis and evaluation of antioxidant, anti-inflammatory and antiulcer activity of conjugates of amino acids with nifedipine.
abstract: A new series of novel (2S)-2-({2-[1,4-dihydro-3,5-bis(methoxycarbonyl)-2,6-dimethyl-4-(2-nitrophenyl)pyridin-1-yl]-2-oxoethyl}amino)-3-(4-hydroxyphenyl) propanoic acid (3a) and its analogues 3b-j has been synthesized. These compounds were evaluated for their in vitro antioxidant activity, anti-inflammatory activity and antiulcer activity. Compounds 3b and f exhibited significant antioxidant action comparable with that of standard. Efficacy against inflammation and ulceration was also found to be significant. The chemical structures of these compounds were confirmed on the basis of spectral data.
authors: School of Pharmaceutical Sciences, Siksha O Anusandhan University, Bhubaneshwar, Orissa, India. bharatbhusans@gmail.com
authors: Bharat Bhusan
authors: BB
authors: Subudhi
authors: Shakti Prasanna
authors: SP
authors: Sahoo
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002087:Butyrates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009543:Nifedipine / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: C568882:(2R)-2-(3-(3,5-bis(methoxycarbonyl)-2,6-dimethyl-4-(2-nitrophenyl)- pyridine-1(4H)-3-oxoacetyl)amino)-4-(methylthio)butanoic Acid; D000596:Amino Acids; D000893:Anti-Inflammatory Agents; D000897:Anti-Ulcer Agents; D000975:Antioxidants; D002087:Butyrates; D011725:Pyridines; D009543:Nifedipine