title: Triple helical recognition of pyrimidine inversions in polypurine tracts of RNA by nucleobase-modified PNA.
abstract: Peptide nucleic acids containing 2-pyrimidinone (P) and 3-oxo-2,3-dihydropyridazine (E) heterocycles recognized C-G and U-A inversions in a polypurine tract of double helical RNA with high affinity and sequence selectivity at pH 6.25. E-modified PNA bound strongly to bacterial A-site RNA, while no binding was observed to the human A-site RNA.
authors: Department of Chemistry, Binghamton University, The State University of New York, Binghamton, New York 13902, USA.
authors: Pankaj
authors: P
authors: Gupta
authors: Thomas
authors: T
authors: Zengeya
authors: Eriks
authors: E
authors: Rozners
mesh_terms: D001483:Base Sequence; D006801:Humans; D055029:Inverted Repeat Sequences; D009690:Nucleic Acid Conformation; D020135:Peptide Nucleic Acids / Q000737:chemistry* / Q000378:metabolism*; D011687:Purines / Q000378:metabolism*; D011744:Pyrimidinones / Q000378:metabolism*; D012313:RNA / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D013379:Substrate Specificity
chemical_list: D020135:Peptide Nucleic Acids; D011687:Purines; D011744:Pyrimidinones; D012313:RNA