title: Thymosin beta 4 is associated with collateral development in coronary artery disease.
abstract: OBJECTIVE
  Thymosin beta 4 (Tβ4) plays an essential role in cardiac vessel development and is currently being developed as a therapeutic agent for the treatment of coronary artery disease (CAD) in some experimental studies. Thus, we aimed to investigate the association of serum Tβ4 levels and collateral formation in patients presenting with severely stenotic CAD.
  
  
  METHODS
  Thirteen patients with poor collateral development and 16 age- and sex-matched patients with good collateral development who had ≥ 95% stenosis in at least one major coronary artery on coronary angiogram (CAG) were enrolled in the study. The Gensini score was calculated for each patient by using CAG results. Collateral development was classified according to the Cohen-Rentrop method. Serum Tβ4 levels were measured with enzyme-linked immune sorbent assay.
  
  
  RESULTS
  There were no statistically significant differences between the two groups in regard to clinical and laboratory characteristics of the patients except for Tβ4 levels. The Tβ4 levels in the well-collateralized study group were found to be significantly higher than those of the poorly collateralized study group and serum Tβ4 levels were positively correlated with the collateral development.
  
  
  CONCLUSIONS
  Our findings suggest that serum Tβ4 levels are significantly associated with the collateral development in severe CAD.
authors: Department of Cardiology, Harran University, Faculty of Medicine, Sanliurfa, Turkey.
authors: Asuman
authors: A
authors: Biçer
authors: Özlem
authors: Ö
authors: Karakurt
authors: Ramazan
authors: R
authors: Akdemir
authors: Gönül
authors: G
authors: Erden
authors: Ali
authors: A
authors: Yildiz
authors: Özge
authors: Ö
authors: Özcan
authors: Yusuf
authors: Y
authors: Sezen
authors: Sadik
authors: S
authors: Açikel
authors: Harun
authors: H
authors: Kiliç
authors: Recep
authors: R
authors: Demirbağ
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D003097:Collateral Circulation; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging; D023921:Coronary Stenosis / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging; D003331:Coronary Vessels / Q000378:metabolism* / Q000503:physiopathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015870:Gene Expression; D006801:Humans; D008297:Male; D008840:Microfilament Proteins / Q000097:blood* / Q000235:genetics; D008875:Middle Aged; D016017:Odds Ratio; D012107:Research Design; D013947:Thymosin / Q000097:blood* / Q000235:genetics; D014421:Turkey; D000099201:Thymosin beta(4)
chemical_list: D015415:Biomarkers; D008840:Microfilament Proteins; D013947:Thymosin; D000099201:Thymosin beta(4)