title: [Perimenarchial growth spurt of the bone].
abstract: Peak bone mass negatively predicts the lifetime cumulative incidence of osteoporosis and fractures. Osteoporosis is a highly prevalent disease and fractures at an advanced age worsen life expectancy. It is therefore important to prevent progression of this disease. However, curbing the loss of already osteoporotic bone is not an easy task. Adolescence is a critical period for bone acquisition. Maximizing peak bone mass during puberty will ultimately guard against osteoporosis. In this review, we focus on the hormonal effects of puberty on bone growth and the importance of appropriate exercise and nutrition to optimize bone accrual.
authors: Department of Pediatrics, Osaka University Graduate School of Medicine, Japan.
authors: Noriyuki
authors: N
authors: Namba
authors: Keiichi
authors: K
authors: Ozono
mesh_terms: D000293:Adolescent; D017195:Adolescent Nutritional Physiological Phenomena / Q000502:physiology; D000728:Androgens / Q000502:physiology*; D001846:Bone Development; D004967:Estrogens / Q000502:physiology*; D015444:Exercise / Q000502:physiology; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D007335:Insulin-Like Growth Factor II / Q000502:physiology*; D010024:Osteoporosis / Q000209:etiology / Q000517:prevention & control; D011627:Puberty / Q000502:physiology*; D012727:Sex Characteristics
chemical_list: D000728:Androgens; D004967:Estrogens; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II