title: Nodular skin reactions in eyebrow permanent makeup: two case reports and an infection by Mycobacterium haemophilum.
abstract: BACKGROUND
  Permanent makeup is becoming more and more popular. The procedures, however, bear some medical risks.
  
  
  OBJECTIVE
  We will describe possible adverse effects of the procedure.
  
  
  METHODS
  This is a report of clinical observations.
  
  
  RESULTS
  We report about two women aged 26 and 47 years, who developed nodules with some delay after permanent tattooing the eyebrows. Clinical, histologic, and laboratory investigations revealed a noninfectious granulomatous reaction not responding to topical calcineurin inhibitor but corticosteroids in the younger patient. In the other woman, an infection by Mycobacterium haemophilum could be identified. A triple combination of clarithromycin, ciprofloxacin, and rifampicin succeeded in clearance of the lesions.
  
  
  CONCLUSIONS
  Adverse reactions after permanent makeup need a medical evaluation to identify health risks and initiate early treatment.
authors: Uwe
authors: U
authors: Wollina
mesh_terms: D000328:Adult; D005138:Eyebrows / Q000382:microbiology* / Q000473:pathology*; D005260:Female; D015745:Granuloma, Foreign-Body / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D009164:Mycobacterium Infections / Q000188:drug therapy*; D018393:Mycobacterium haemophilum; D013653:Tattooing / Q000009:adverse effects*