title: A preliminary model of gastrointestinal electromechanical coupling.
abstract: Gastrointestinal (GI) motility is coordinated by several cooperating mechanisms, including electrical slow wave activity, the enteric nervous system (ENS), and other factors. Slow waves generated in interstitial cells of Cajal (ICC) depolarize smooth muscle cells (SMC), generating basic GI contractions. This unique electrical coupling presents an added layer of complexity to GI electromechanical models, and a current barrier to further progress is the lack of a framework for ICC-SMC-contraction coupling. In this study, an initial framework for the electromechanical coupling was developed in a 2-D model. At each solution step, the slow wave propagation was solved first and  [Ca(2+)](i) in the SMC model was related to a  Ca(2+)-tension-extension relationship to simulate active contraction. With identification of more GI-specific constitutive laws and material parameters, the ICC-SMC-contraction approach may underpin future GI electromechanical models of health and disease states.
authors: Auckland Bioengineering Institute, The University of Auckland, Auckland 1010, New Zealand. peng.du@auckland.ac.nz
authors: Peng
authors: P
authors: Du
authors: Yong Cheng
authors: YC
authors: Poh
authors: Jee Lean
authors: JL
authors: Lim
authors: Viveka
authors: V
authors: Gajendiran
authors: Greg
authors: G
authors: O'Grady
authors: Martin L
authors: ML
authors: Buist
authors: Andrew J
authors: AJ
authors: Pullan
authors: Leo K
authors: LK
authors: Cheng
mesh_terms: D002118:Calcium / Q000378:metabolism; D055724:Electrophysiological Phenomena; D005769:Gastrointestinal Motility / Q000502:physiology*; D041981:Gastrointestinal Tract / Q000502:physiology*; D006801:Humans; D056885:Interstitial Cells of Cajal / Q000502:physiology; D040542:Mechanotransduction, Cellular / Q000502:physiology; D008954:Models, Biological; D009130:Muscle, Smooth / Q000502:physiology
chemical_list: D002118:Calcium