title: Hemoglobin Lepore Hollandia in India.
abstract: BACKGROUND
  Hb Lepore is a structurally abnormal hemoglobin in which the abnormal globin chain is a hybrid or fused δβ globin chain. In the heterozygous condition, Hb Lepore produces the phenotype of heterozygous β thalassemia with slightly raised HbF levels.
  
  
  METHODS
  Using a combination of HPLC and DNA analysis, we have identified eight individuals with Hb Lepore Hollandia from three families including seven heterozygotes and one compound heterozygote with β thalassemia who presented with a severe clinical phenotype.
  
  
  RESULTS
  All the heterozygotes showed elevated levels of HbF with a mean of 3.2%. Hb Lepore Hollandia genes were associated with a single β globin cluster haplotype [- - - - - - +] indicating a common origin.
  
  
  CONCLUSIONS
  Hemoglobin Lepore Hollandia is a relatively uncommon variant in the Indian population and can be identified using a combination of chromatographic, electrophoretic, and molecular analysis.
authors: National Institute of Immunohaematology (ICMR), Parel, Mumbai, India. anitahnadkarni@yahoo.com
authors: A
authors: A
authors: Nadkarni
authors: K
authors: K
authors: Italia
authors: P
authors: P
authors: Sawant
authors: K
authors: K
authors: Ghosh
authors: R
authors: R
authors: Colah
mesh_terms: D005190:Family; D005319:Fetal Hemoglobin; D006453:Hemoglobinopathies / Q000453:epidemiology / Q000235:genetics; D006455:Hemoglobins, Abnormal; D006801:Humans; D007194:India / Q000453:epidemiology; D010641:Phenotype; D017086:beta-Thalassemia / Q000453:epidemiology / Q000235:genetics*
chemical_list: D006455:Hemoglobins, Abnormal; C477064:hemoglobin Lepore-Hollandia; D005319:Fetal Hemoglobin; C037659:hemoglobin Lepore