title: Metastatic mucinous adenocarcinoma of the ovary is characterized by advanced patient age, small tumor size, and elevated serum CA125.
abstract: OBJECTIVE
  An intraoperative diagnosis in cases with primary and metastatic ovarian carcinomas is important for adequate treatment. The aim of the present study was to find a reliable method to discriminate primary from metastatic mucinous adenocarcinomas (MACs) of the ovary intraoperatively.
  
  
  METHODS
  Clinical features of all primary and metastatic mucinous ovarian carcinomas diagnosed from 1994 to 2008 at the Osaka University and Osaka Rosai Hospitals, Osaka, Japan, were reviewed retrospectively.
  
  
  RESULTS
  Among the 73 MACs, 51 (70%) and 22 cases (30%) were diagnosed as primary and metastatic ovarian carcinomas, respectively. The distributions of tumor size, patient age, and serum CA125 level were significantly different between primary and metastatic cases. Our algorithm that categorizes patients ≥50 years whose tumor size was <10 cm into metastatic cases, and patients <50 years, or the ones whose tumor size was ≥10 cm, into primary tumors, provided an 84% accuracy in our population.
  
  
  CONCLUSIONS
  A more reliable method to discriminate primary from metastatic MACs of the ovary by patient age and serum tumor markers was derived from our study population.
authors: Departments of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, Japan.
authors: Makiko
authors: M
authors: Maeda-Taniguchi
authors: Yutaka
authors: Y
authors: Ueda
authors: Takahito
authors: T
authors: Miyake
authors: Takashi
authors: T
authors: Miyatake
authors: Toshihiro
authors: T
authors: Kimura
authors: Kiyoshi
authors: K
authors: Yoshino
authors: Masami
authors: M
authors: Fujita
authors: Tomoko
authors: T
authors: Wakasa
authors: Hiroshi
authors: H
authors: Ohashi
authors: Eiichi
authors: E
authors: Morii
authors: Takayuki
authors: T
authors: Enomoto
authors: Tadashi
authors: T
authors: Kimura
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000097:blood / Q000145:classification* / Q000473:pathology / Q000556:secondary; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D018394:CA-125 Antigen / Q000097:blood*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000097:blood / Q000145:classification* / Q000473:pathology / Q000556:secondary; D012189:Retrospective Studies
chemical_list: D018394:CA-125 Antigen