title: The IL-10 promoter polymorphism at position -592 is correlated with susceptibility to occult HBV infection.
abstract: Occult hepatitis B infection (OBI) is characterized as a form of hepatitis in which detectable amounts of HBV-DNA can be monitored in the peripheral blood of patients whereas the hepatitis B surface antigen is undetectable. The main aim of this study was to investigate whether there is a relationship between OBI and single nucleotide polymorphisms in the -592 region of the IL-10 gene. In this study, the polymorphism at position -592 of the IL-10 promoter of 57 OBI cases was compared and correlated to that of 100 healthy controls by PCR-RFLP techniques. Our results showed that patient and control groups had significant differences regarding genotypes and alleles of the -592 polymorphism in the IL-10 gene. Based on our results, it can be concluded that the -592 polymorphism within the promoter of the IL-10 gene is associated with OBI.
authors: Molecular-Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors: Behzad Nasiri
authors: BN
authors: Ahmadabadi
authors: Gholamhossein
authors: G
authors: Hassanshahi
authors: Mohammad Kazemi
authors: MK
authors: Arababadi
authors: Cristiana
authors: C
authors: Leanza
authors: Derek
authors: D
authors: Kennedy
mesh_terms: D004279:DNA, Viral / Q000097:blood; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006509:Hepatitis B / Q000235:genetics* / Q000821:virology; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006515:Hepatitis B virus / Q000302:isolation & purification; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic
chemical_list: D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D016753:Interleukin-10