title: Clinical implication of coronary tortuosity in patients with coronary artery disease.
abstract: BACKGROUND
  Coronary tortuosity (CT) is a common coronary angiography finding. The exact pathogenesis, clinical implication and long-term prognosis of CT are not fully understood. The purpose of this study is to investigate the clinical characteristics of CT in patients with suspected coronary artery disease (CAD) in a Chinese population.
  
  
  METHODS
  A total of 1010 consecutive patients underwent coronary angiography with complaints of chest pain or related symptoms were included in the present study (544 male, mean age: 64±11 years). CT was defined by the finding of ≥3 bends (defined as ≥45° change in vessel direction) along main trunk of at least one artery in systole and in diastole. Patients with or without CAD were further divided into CT-positive and CT-negative groups, all patients were followed up for the incidence of major adverse cardiovascular events (MACE) for 2 to 4 years.
  
  
  RESULTS
  The prevalence of CT was 39.1% in this patient cohort and incidence of CT was significantly higher in female patients than that in male patients (OR = 2.603, 95%CI 1.897, 3.607, P<0.001). CT was positively correlated with essential hypertension (OR = 1.533, 95%CI 1.131, 2.076, P = 0.006) and negatively correlated with CAD (OR = 0.755, 95%CI 0.574, 0.994, P = 0.045). MACE during follow up was similar between CAD patients with or without CT.
  
  
  CONCLUSIONS
  CT is more often seen in females and positively correlated with hypertension and negatively correlated with coronary atherosclerosis.
authors: Department of Cardiology, Zhongda Hospital, Southeast University, Nanjing, China.
authors: Yang
authors: Y
authors: Li
authors: Chengxing
authors: C
authors: Shen
authors: Yanan
authors: Y
authors: Ji
authors: Yi
authors: Y
authors: Feng
authors: Genshan
authors: G
authors: Ma
authors: Naifeng
authors: N
authors: Liu
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging*; D003327:Coronary Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012737:Sex Factors