title: Cognitive function in prepubertal children with obstructive sleep apnea: a modifying role for NADPH oxidase p22 subunit gene polymorphisms?
abstract: Pediatric obstructive sleep apnea (OSA) may lead to neurocognitive dysfunction, but not in everyone affected. The frequencies of NADPH oxidase (NOX) polymorphisms in the p22phox subunit were similar between children with OSA and controls, except for rs6520785 and rs4673, the latter being significantly more frequent among the OSA children without deficits than with deficits (p<0.02). Similarly, 8-hydroxydeoxyguanine urine levels and NOX activity were lower among children without cognitive deficits and particularly among those with the rs4673 polymorphism. Thus, polymorphisms within the NOX gene or its functional subunits may account for important components of the variance in cognitive function deficits associated with OSA in children.
authors: Section of Pediatric Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Illinois, USA. dgozal@peds.bsd.uchicago.edu
authors: David
authors: D
authors: Gozal
authors: Abdelnaby
authors: A
authors: Khalyfa
authors: Oscar Sans
authors: OS
authors: Capdevila
authors: Leila
authors: L
authors: Kheirandish-Gozal
authors: Ahamed A
authors: AA
authors: Khalyfa
authors: Jinkwan
authors: J
authors: Kim
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D016022:Case-Control Studies; D002648:Child; D003071:Cognition; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D019255:NADPH Oxidases / Q000235:genetics*; D011110:Polymorphism, Genetic; D011627:Puberty; D060888:Real-Time Polymerase Chain Reaction; D020181:Sleep Apnea, Obstructive / Q000201:enzymology / Q000235:genetics / Q000503:physiopathology*
chemical_list: D000080242:8-Hydroxy-2'-Deoxyguanosine; D019255:NADPH Oxidases; D003849:Deoxyguanosine