title: Salivary cortisol and soluble tumor necrosis factor-α receptor II responses to multiple experimental modalities of acute pain.
abstract: The present study compared cortisol and soluble tumor necrosis factor-α receptor II (sTNFαRII) responses provoked by cold pressor, hot water, ischemic, and neutral water (i.e., room temperature) modalities. Oral fluid samples were collected before, immediately after, and during recovery to assess physiological responses. From baseline, the cold pressor, but not hot water or ischemic modalities, produced a significant time-dependent elevation in cortisol, whereas cortisol significantly decreased for the neutral water task. When compared to baseline, the cold pressor, hot water, and ischemic modalities were associated with decreased sTNFαRII responses over time. The sTNFαRII response to neutral water initially decreased but returned to approximate baseline levels. Pain ratings were positively associated with cortisol increase from baseline and the overall cortisol response was negatively associated with the overall sTNFαRII response.
authors: University of Florida College of Dentistry, Gainesville, Florida 32610, USA. bgoodin1@ufl.edu
authors: Burel R
authors: BR
authors: Goodin
authors: Noel B
authors: NB
authors: Quinn
authors: Christopher D
authors: CD
authors: King
authors: Gayle G
authors: GG
authors: Page
authors: Jennifer A
authors: JA
authors: Haythornthwaite
authors: Robert R
authors: RR
authors: Edwards
authors: Laura
authors: L
authors: Stapleton
authors: Lynanne
authors: L
authors: McGuire
mesh_terms: D059787:Acute Pain / Q000276:immunology*; D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000276:immunology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000276:immunology / Q000378:metabolism*; D012463:Saliva / Q000276:immunology; D013696:Temperature; D014867:Water
chemical_list: D047889:Receptors, Tumor Necrosis Factor, Type II; D014867:Water; D006854:Hydrocortisone