title: The challenges of assessing acute kidney injury in infants.
abstract: Definitions of pediatric acute kidney injury (AKI) use changes of serum creatinine. There is a paucity of well-designed studies in infants because of creatinine age-dependency. The emerging role of cystatin C as a superior marker of renal dysfunction led to a carefully conducted study on AKI in infants by Zappitelli et al. This Commentary calls for the development of age-independent serum creatinine and estimated glomerular filtration rate z scores.
authors: Department of Pediatrics, Schulich School of Medicine and Dentistry, London, Ontario, Canada. guido.filler@lhsc.on.ca
authors: Guido M
authors: GM
authors: Filler
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood* / Q000209:etiology*; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D055316:Cystatin C / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000097:blood* / Q000209:etiology*
chemical_list: C525030:CST3 protein, human; D055316:Cystatin C