title: Gynecologic clostridial toxic shock in women of reproductive age.
abstract: Clostridial toxic shock, caused by Clostridium sordellii or Clostridium perfringens, is a rare and largely fatal syndrome among reproductive-aged women with genital tract infection, and may occur following various pregnancy outcomes or without pregnancy. Clinicians should be aware of common clinical features of this very rapidly-progressing syndrome including abdominal pain, tachycardia, hypotension, third-space fluid accumulations, hemoconcentration, and marked leukemoid response, often with lack of fever. In this review, we summarize known cases through mid-2011 and information on clinical presentation, diagnosis, treatment, and results of recent investigations regarding pathogenesis, including germination, toxins, and host response that may have important implications for development of preventive or therapeutic interventions.
authors: Division of Reproductive Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, NE, Mailstop K-23, Atlanta, GA, 30341, USA, saz3@cdc.gov.
authors: Suzanne
authors: S
authors: Zane
authors: Jeannette
authors: J
authors: Guarner