title: [Association between the polymorphisms of cluster of differentiation 14 gene promoters and the susceptibility of multiple organ dysfunction syndrome after severe chest trauma].
abstract: OBJECTIVE
  To investigate the polymorphisms of cluster of differentiation 14(CD14)gene promoters and explore whether such polymorphisms are associated with the susceptibility to multiple organ dysfunction syndrome(MODS) in Chongqing population.
  
  
  METHODS
  The single nucleotide polymorphisms of the promoter region of CD14 gene at position -1145 and -159 were detected using polymerase chain reaction-restriction fragment length polymorphism method in 106 patients with severe chest trauma, among whom 47 were with MODS.
  
  
  RESULTS
  Trauma patients carrying G allele tended to have a higher risk of MODS than those carrying A allele at position-1145, the MODS scores in trauma patients carrying G allele were significantly higher than those carrying A allele (P=0.217 for dominant effect and P=0.037 for recessive effect), and the MODS scores in trauma patients carrying T allele were significantly higher than those carrying C allele at position -159 (P=0.048 for dominant effect and P=0.198 for recessive effect). The genotypes of CD14 gene at positions -1145 and -159 were significantly correlated with the MODS scores (P=0.043,P=0.046). Compare with single-point mutation, simultaneous two-point mutation had significantly higher risk of MODS (Pü0.01), while the difference of MODS scores showed no statistical significance (P=0.239).
  
  
  CONCLUSIONS
  The polymorphisms of CD14 gene promoters are associated with MODS after severe chest trauma in Chongqing population.
authors: Department of Cardiothoracic Surgery, the First College of Clinical Medical Science, China.
authors: Yun
authors: Y
authors: Liu
authors: Ding-yuan
authors: DY
authors: Du
authors: Xu
authors: X
authors: Hu
authors: Xiao-yong
authors: XY
authors: Xiang
authors: Dao-kui
authors: DK
authors: Xia
authors: Wei
authors: W
authors: Gu
authors: Jian-xin
authors: JX
authors: Jiang
authors: Chao-bing
authors: CB
authors: Liu
authors: Wen-chao
authors: WC
authors: Qin
mesh_terms: D000328:Adult; D005260:Female; D005838:Genotype; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000235:genetics*; D008297:Male; D009102:Multiple Organ Failure / Q000209:etiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011401:Promoter Regions, Genetic; D013898:Thoracic Injuries / Q000150:complications
chemical_list: D018950:Lipopolysaccharide Receptors