title: Enantioselective total synthesis of the potent anti-HIV nucleoside EFdA.
abstract: A concise enantioselective total synthesis of 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA), an extremely potent anti-HIV agent, has been accomplished from (R)-glyceraldehyde acetonide in 18% overall yield by a 12-step sequence involving a highly diastereoselective ethynylation of an α-alkoxy ketone intermediate.
authors: Laboratory of Applied Bioorganic Chemistry, Graduate School of Agricultural Science, Tohoku University, Tsutsumidori-Amamiyamachi, Sendai 981-8555, Japan.
authors: Masayuki
authors: M
authors: Kageyama
authors: Tomohiro
authors: T
authors: Nagasawa
authors: Mayumi
authors: M
authors: Yoshida
authors: Hiroshi
authors: H
authors: Ohrui
authors: Shigefumi
authors: S
authors: Kuwahara
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis*; D003839:Deoxyadenosines / Q000138:chemical synthesis*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D019380:Anti-HIV Agents; D003839:Deoxyadenosines; C558823:islatravir