title: Pharmacogenetics and pharmacogenomics of thienopyridines: clinically relevant?
abstract: Pharmacogenetics have been touted as the future of personalized medicine where genetic biomarkers will guide therapeutic approach. The currently approved thienopyridines, prasugrel and clopidogrel, are prodrugs requiring conversion to active metabolite through the cytochrome P450 system. Genetic variation has been associated with the pharmacokinetic, pharmacodynamic, and clinical response to clopidogrel, but not to prasugrel. This review aims to summarize the recent pharmacogenetic findings associated with the response to thienopyridine treatment. Additionally, considerations for the incorporation of genetic biomarkers into clinical practice will be discussed in the context of thienopyridines.
authors: Department of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN, USA. closekirkwoodconsulting@gmail.com
authors: Sandra L
authors: SL
authors: Close
mesh_terms: D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005819:Genetic Markers; D006801:Humans; D010597:Pharmacogenetics; D010975:Platelet Aggregation Inhibitors / Q000378:metabolism / Q000494:pharmacology*; D057285:Precision Medicine / Q000379:methods; D011355:Prodrugs; D058924:Thienopyridines / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D005819:Genetic Markers; D010975:Platelet Aggregation Inhibitors; D011355:Prodrugs; D058924:Thienopyridines; D003577:Cytochrome P-450 Enzyme System