title: Application of ring-closing metathesis for the synthesis of benzo[3,4]azepino[1,2-b]isoquinolin-9-ones.
abstract: Cycloaddition reaction between toluamides and benzonitriles was applied to prepare the 3-arylisoquinolines, and their chemical transformation to the dienes 4 was performed. The ring-closing metathesis (RCM) reaction afforded the desired heterocyclic compounds, benzo[3,4]azepino[1,2-b]isoquinolinones 5 in good yield.
authors: College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, Korea.
authors: Hue Thi My
authors: HT
authors: Van
authors: Daulat Bikram
authors: DB
authors: Khadka
authors: Thanh Nguyen
authors: TN
authors: Le
authors: Su Hui
authors: SH
authors: Yang
authors: Won-Jea
authors: WJ
authors: Cho
mesh_terms: D000577:Amides / Q000737:chemistry; D001552:Benzazepines / Q000138:chemical synthesis* / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D007546:Isoquinolines / Q000138:chemical synthesis / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009570:Nitriles / Q000737:chemistry
chemical_list: D000577:Amides; D001552:Benzazepines; D006571:Heterocyclic Compounds; D007546:Isoquinolines; D009570:Nitriles; C569165:benzo(3,4)azepino(1,2-b)-isoquinolinone; C014356:benzonitrile