title: On acetyl-CoA as a gauge of cellular metabolic state.
abstract: Many activities within a cell must be intimately coordinated with its metabolic state. Understanding these connections to metabolism is critical to deciphering the regulation of a variety of cellular processes. However, despite intensive research in these areas, the precise mechanisms by which a cell monitors its metabolic state remain controversial and poorly understood. Herein, we discuss the thesis that intracellular levels of the metabolite acetyl-CoA represent a critical gauge of cellular metabolic state, which is cleverly monitored by the cell through dynamic acetylation modifications to direct a variety of outputs connected to energy metabolism, cell growth, and survival.
authors: Department of Biochemistry, UT Southwestern Medical Center, Dallas, Texas 75390-9038, USA.
authors: L
authors: L
authors: Cai
authors: B P
authors: BP
authors: Tu
mesh_terms: D000105:Acetyl Coenzyme A / Q000378:metabolism*; D000107:Acetylation; D000818:Animals; D002477:Cells / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D006657:Histones / Q000378:metabolism; D006801:Humans; D008322:Mammals / Q000378:metabolism
chemical_list: D006657:Histones; D000105:Acetyl Coenzyme A