title: A pilot study of the epidemiology and associations of pulse pressure variation among non-cardiac surgery critically ill patients.
abstract: BACKGROUND
  A pulse pressure variation (PPV) ≥ 13% of mean arterial pressure (MAP) is an accepted marker of a fluid-responsive state. However, there is no study of its epidemiology and associations among non-cardiac critically ill patients.
  
  
  OBJECTIVE
  To conduct a pilot study of the epidemiology and associations of a PPV ≥ 13% among non-cardiac critically ill patients.
  
  
  METHODS
  Prospective observational study.
  
  
  METHODS
  Intensive care unit of a university hospital.
  
  
  METHODS
  Cohort of 37 sedated critically ill patients undergoing mandatory ventilation.
  
  
  METHODS
  PPV values, tidal volume and peak airway pressure, MAP, heart rate (HR) and central venous pressure (CVP) collected every 15 minutes; fluid balance collected hourly; correlation between PPV and these variables.
  
  
  RESULTS
  450 PPV measurements were collated. The PPV value was ≥ 13% in 86 (19%) measurements and was observed in two consecutive measurements in 68 (15%) of cases. On multivariable analysis, mean PPV was significantly correlated with CVP (P=0.04), HR (P<0.001) and peak airway pressure (P=0.001), but not fluid balance (P=0.3).
  
  
  CONCLUSIONS
  Among non-cardiac surgery mechanically ventilated patients, a PPV in the fluid-responsive range was present in one-fifth of measurements and showed logical correlations with relevant haemodynamic and mechanical ventilation-related variables. Our results provide a rationale for a more comprehensive evaluation of PPV measurement in suitable critically ill patients.
authors: Department of Emergency Medicine, Kwan Dong University, Seoul, Korea.
authors: In Byung
authors: IB
authors: Kim
authors: Nigel
authors: N
authors: Fealy
authors: Ian
authors: I
authors: Baldwin
authors: Rinaldo
authors: R
authors: Bellomo
mesh_terms: D000328:Adult; D001795:Blood Pressure Determination; D016638:Critical Illness / Q000453:epidemiology / Q000628:therapy; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D012121:Respiration, Artificial; D013514:Surgical Procedures, Operative