title: Cutaneous accumulation of plasmacytoid dendritic cells associated with acute myeloid leukemia: a rare condition distinct from blastic plasmacytoid dendritic cell neoplasm.
abstract: A cutaneous infiltrate composed of plasmacytoid dendritic cells may occasionally occur in a patient suffering from a myeloid neoplasm. To date, the clinical and pathological features associated with this event remains poorly characterized. Herein, we report a patient with acute myeloid leukemia who developed pruritic papules or erythematous plaques scattered on the skin. Microscopic examination showed a dermal infiltrate rich in plasmacytoid dendritic cells expressing CD4, CD43, CD68, granzyme B, CD123, CD303 [blood dendritic cell antigen 2 (BDCA-2)], CD2-associated protein (CD2AP) and T-cell leukemia/lymphoma oncogene 1 (TCL1). Our observation illustrates further that cutaneous lesions associated with some myeloid neoplasms, especially those featuring a monocytic component, may be composed of plasmacytoid dendritic cells. Because of differences in clinical, pathological and genetic features, this rare condition should be distinguished from blastic plasmacytoid dendritic cell neoplasm.
authors: Institut de Pathologie et de Génétique (IPG), Gosselies, Belgium. jldargent@hotmail.com
authors: Jean-Louis
authors: JL
authors: Dargent
authors: André
authors: A
authors: Delannoy
authors: Philippe
authors: P
authors: Pieron
authors: Bernard
authors: B
authors: Husson
authors: Caroline
authors: C
authors: Debecker
authors: Tony
authors: T
authors: Petrella
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D003713:Dendritic Cells / Q000378:metabolism / Q000473:pathology*; D020405:Dermis / Q000378:metabolism / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000378:metabolism; D008297:Male; D010950:Plasma Cells / Q000378:metabolism / Q000473:pathology*; D010954:Plasmacytoma / Q000175:diagnosis* / Q000378:metabolism; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor