title: C868T single nucleotide polymorphism and HIV type 1 disease progression among postpartum women in Kenya.
abstract: The C868T single nucleotide polymorphism in the CD4 receptor encodes an amino acid substitution of tryptophan for arginine in the third domain. Previous studies suggest that C868T increases the risk of HIV-1 acquisition; however, the influence of this single nucleotide polymorphism (SNP) on disease progression has not been established. The presence of the C868T polymorphism was not statistically significantly associated with HIV-1 disease progression outcomes in a cohort of postpartum Kenyan women.
authors: Department of Medicine, University of Washington, Seattle, Washington 98104, USA. ryc@u.washington.edu
authors: Robert Y
authors: RY
authors: Choi
authors: Keith R
authors: KR
authors: Fowke
authors: Jennifer
authors: J
authors: Juno
authors: Barbara
authors: B
authors: Lohman-Payne
authors: Julius O
authors: JO
authors: Oyugi
authors: Elizabeth R
authors: ER
authors: Brown
authors: Rose
authors: R
authors: Bosire
authors: Grace
authors: G
authors: John-Stewart
authors: Carey
authors: C
authors: Farquhar
mesh_terms: D000328:Adult; D001120:Arginine; D015704:CD4 Antigens / Q000235:genetics*; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D007630:Kenya / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide; D049590:Postpartum Period / Q000235:genetics*; D011247:Pregnancy; D014364:Tryptophan; D019562:Viral Load; D015215:Zidovudine / Q000627:therapeutic use
chemical_list: D015704:CD4 Antigens; D015215:Zidovudine; D014364:Tryptophan; D001120:Arginine