title: Clinicopathologic variables predicting tumor response to neoadjuvant chemotherapy in patients with locally advanced gastric cancer.
abstract: OBJECTIVE
  To identify clinicopathologic variables that could predict pathologic tumor response to neoadjuvant chemotherapy for patients with locally advanced gastric cancer.
  
  
  METHODS
  The study enrolled 108 patients who underwent neoadjuvant chemotherapy followed by surgery between July 2004 and December 2010. Tumor responses to neoadjuvant chemotherapy were assessed in terms of tumor regression. Statistical analyses were performed to identify factors associated with pathologic tumor response.
  
  
  RESULTS
  Tumor regression was found in 22.2% (24/108) patients, patients with tumor regression observed better overall survival as compared to that of patients without tumor regression. Univariate and multivariate analyses observed that both tumor differentiation and tumor size were independent predictors of tumor regression.
  
  
  CONCLUSIONS
  This study suggests that both tumor differentiation and tumor size is the most important clinical predicator of pathologic tumor response, it may be of benefit in the selection of treatment options in locally advanced gastric cancer.
authors: Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University College of Medicine, Hangzhou, China.
authors: Lin Bo
authors: LB
authors: Wang
authors: Rong Yue
authors: RY
authors: Teng
authors: Zi Nong
authors: ZN
authors: Jiang
authors: Wen Xian
authors: WX
authors: Hu
authors: Min Jun
authors: MJ
authors: Dong
authors: Xiao Ming
authors: XM
authors: Yuan
authors: Wen Jun
authors: WJ
authors: Chen
authors: Mei
authors: M
authors: Jin
authors: Jian Guo
authors: JG
authors: Shen
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D000328:Adult; D000368:Aged; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009361:Neoplasm Invasiveness; D011379:Prognosis; D017678:Sex Distribution; D013274:Stomach Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy*