title: Protein export at the ER: loading big collagens into COPII carriers.
abstract: COPII vesicles mediate the export of secretory cargo from endoplasmic reticulum (ER) exit sites. However, of 60-90 nm diameter COPII vesicles are too small to accommodate secreted molecules such as the collagens. The ER exit site-located proteins TANGO1 and cTAGE5 are required for the transport of collagens and therefore provide a means to understand the export of big cargo and the mechanism of COPII carrier size regulation commensurate with cargo dimensions.
authors: ICREA, Barcelona, Spain. vivek.malhotra@crg.eu
authors: Vivek
authors: V
authors: Malhotra
authors: Patrik
authors: P
authors: Erlmann
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000378:metabolism; D051784:Aryl Hydrocarbon Receptor Nuclear Translocator / Q000378:metabolism; D022181:COP-Coated Vesicles / Q000378:metabolism*; D003094:Collagen / Q000378:metabolism*; D004330:Drosophila / Q000378:metabolism; D029721:Drosophila Proteins / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism; D006801:Humans; D051379:Mice; D009363:Neoplasm Proteins / Q000378:metabolism; D021381:Protein Transport / Q000502:physiology
chemical_list: D000951:Antigens, Neoplasm; D029721:Drosophila Proteins; C109278:MIA2 protein, human; D009363:Neoplasm Proteins; C109766:tgo protein, Drosophila; D051784:Aryl Hydrocarbon Receptor Nuclear Translocator; D003094:Collagen