title: Remarkable difference of somatic mutation patterns between oncogenes             and tumor suppressor genes.
abstract: Cancers arise owing to mutations that confer selective growth advantages on the cells in a subset of tumor suppressor and/or oncogenes. To understand oncogenesis and diagnose cancers, it is crucial to discriminate these two groups of genes by using the difference in their mutation patterns. Here, we investigated>120,000 mutation samples in 66 well-known tumor suppressor genes and oncogenes of the COSMIC database, and found a set of significant differences in mutation patterns (e.g., non-3n-indel, non-sense SNP and mutation hotspot) between them. By screening the best measurement, we developed indices to readily distinguish one from another and predict clearly the unknown oncogenesis genes as tumor suppressors (e.g., ASXL1, HNF1A and KDM6A) or oncogenes (e.g., FOXL2, MYD88 and TSHR). Based on our results, a third gene group can be classified, which has a mutational pattern between tumor suppressors and oncogenes. The concept of the third gene group could help to understand gene function in different cancers or individual patients and to know the exact function of genes in oncogenesis. In conclusion, our study provides further insights into cancer-related genes and identifies several potential therapeutic targets.
authors: State Key Laboratory of Pharmaceutical Biotechnology, Department of Biology, Nanjing University, Nanjing, PR China.
authors: Haoxuan
authors: H
authors: Liu
authors: Yuhang
authors: Y
authors: Xing
authors: Sihai
authors: S
authors: Yang
authors: Dacheng
authors: D
authors: Tian
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics; D016147:Genes, Tumor Suppressor; D006801:Humans; D008957:Models, Genetic; D009154:Mutation; D009363:Neoplasm Proteins / Q000145:classification / Q000235:genetics; D009369:Neoplasms / Q000235:genetics*; D009857:Oncogenes
chemical_list: D009363:Neoplasm Proteins