title: [Neonatal intoxication with pyrimethamine: risk due to the absence of pediatric formulation?].
abstract: Curative treatment of congenital toxoplasmosis is based on the association of pyrimethamine and sulfonamide. There is currently no pediatric galenic formulation. We report the case of a newborn child affected by asymptomatic congenital toxoplasmosis who received an overdose of pyrimethamine. The patient received a dose of pyrimethamine 4 times, equal to 100 times the recommended dose, due to an error in the prescription. He had partial seizures 48 h after the last medicinal absorption. We noted a lack of appetite and vomiting, with a favorable progression in 5 days. Blood analysis showed isolated, spontaneously regressive moderate cholestasis. We propose a pharmacological clarification on the treatment of congenital toxoplasmosis.
authors: Service de néonatologie, hôpital Armand-Trousseau, faculté de médecine, AP-HP, université Pierre-et-Marie-Curie, 26, avenue du Dr-Arnold-Netter, 75571 Paris cedex 12, France.
authors: M
authors: M
authors: Genuini
authors: C
authors: C
authors: Freihuber
authors: I
authors: I
authors: Girard
authors: I
authors: I
authors: de Montgolfier
authors: F
authors: F
authors: Kieffer
authors: D
authors: D
authors: Mitanchez
mesh_terms: D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000009:adverse effects*; D062787:Drug Overdose; D006801:Humans; D007231:Infant, Newborn; D008508:Medication Errors / Q000009:adverse effects; D011379:Prognosis; D011739:Pyrimethamine / Q000008:administration & dosage / Q000009:adverse effects*; D012640:Seizures / Q000139:chemically induced*; D014125:Toxoplasmosis, Congenital / Q000188:drug therapy*
chemical_list: D000981:Antiprotozoal Agents; D011739:Pyrimethamine