title: Challenges in antimalarial drug discovery.
abstract: Malaria is one of the most devastating diseases in the world, affecting almost 225 million people a year, and causing over 780,000 deaths, most of which are children under the age of 5 years. Following the recent call for the eradication of the disease, supported by the WHO, there has been increasing investment into antimalarial drug-discovery projects. These activities are aimed at generating the next generation of molecules focused on the treatment and transmission-blocking of Plasmodium falciparum and Plasmodium vivax endo- and exo-erythrocytic stages of the parasite. This article summarizes the current top-level thinking regarding the prosecution of such endeavors and the disease-specific considerations in project planning.
authors: Medicines for Malaria Venture, Route de Pré-Bois 20, PO Box 1826, 1215 Geneva 15, Switzerland. burrowsj@mmv.org
authors: Jeremy N
authors: JN
authors: Burrows
authors: Didier
authors: D
authors: Leroy
authors: Julie
authors: J
authors: Lotharius
authors: David
authors: D
authors: Waterson
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D002626:Chemistry, Pharmaceutical; D055808:Drug Discovery / Q000379:methods* / Q000458:organization & administration / Q000639:trends; D006801:Humans; D008288:Malaria / Q000097:blood / Q000188:drug therapy* / Q000635:transmission; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials