title: Molecular mechanism of protein folding in the cell.
abstract: F.-Ulrich Hartl and Arthur Horwich will share this year's Lasker Basic Medical Science Award for the discovery of the cell's protein-folding machinery, exemplified by cage-like structures that convert newly synthesized proteins into their biologically active forms. Their fundamental findings reveal mechanisms that operate in normal physiologic processes and help to explain the problems that arise in diseases of protein folding.
authors: Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520-8002, USA. james.rothman@yale.edu
authors: James E
authors: JE
authors: Rothman
authors: Randy
authors: R
authors: Schekman
mesh_terms: D000818:Animals; D001363:Awards and Prizes; D001695:Biology / Q000266:history*; D004926:Escherichia coli / Q000378:metabolism; D050884:HSP72 Heat-Shock Proteins / Q000378:metabolism; D049673:History, 20th Century; D006801:Humans; D008958:Models, Molecular; D018832:Molecular Chaperones / Q000378:metabolism; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D014481:United States
chemical_list: D050884:HSP72 Heat-Shock Proteins; D018832:Molecular Chaperones; D011506:Proteins