title: Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M.
abstract: Finding the target: activity-based proteomic profiling probes based on the depalmitoylation inhibitors palmostatin B and M have been synthesized and were found to target acyl protein thioesterase 1 (APT1) and 2 (APT2) in cells.
authors: Max-Planck-Institut für Molekulare Physiologie, Abt. Chemische Biologie, Dortmund, Germany.
authors: Marion
authors: M
authors: Rusch
authors: Tobias J
authors: TJ
authors: Zimmermann
authors: Marco
authors: M
authors: Bürger
authors: Frank J
authors: FJ
authors: Dekker
authors: Kristina
authors: K
authors: Görmer
authors: Gemma
authors: G
authors: Triola
authors: Andreas
authors: A
authors: Brockmeyer
authors: Petra
authors: P
authors: Janning
authors: Thomas
authors: T
authors: Böttcher
authors: Stephan A
authors: SA
authors: Sieber
authors: Ingrid R
authors: IR
authors: Vetter
authors: Christian
authors: C
authors: Hedberg
authors: Herbert
authors: H
authors: Waldmann
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D064429:Fatty Acid Synthases / Q000037:antagonists & inhibitors*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D010170:Palmitoyl-CoA Hydrolase / Q000037:antagonists & inhibitors*; D011420:Propiolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D020543:Proteome; D015398:Signal Transduction / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000737:chemistry / Q000494:pharmacology*; D013869:Thiolester Hydrolases / Q000037:antagonists & inhibitors*; D018631:ras Proteins / Q000378:metabolism*
chemical_list: D004791:Enzyme Inhibitors; D020543:Proteome; D013450:Sulfones; C578782:palmostatin B; C578783:palmostatin M; D011420:Propiolactone; D064429:Fatty Acid Synthases; D013869:Thiolester Hydrolases; C022738:thioesterase II; D010170:Palmitoyl-CoA Hydrolase; D018631:ras Proteins