title: In vitro antiviral activities of extracts derived from Daucus maritimus seeds.
abstract: The antiviral activities of extracts from Daucus maritimus seeds were investigated against the reverse transcriptase of human immunodeficiency virus (HIV) type 1 and a panel of RNA-dependent RNA polymerases of dengue virus, West Nile virus (WNV) and hepatitis C virus (HCV). The extracts showed moderate to potent inhibition rates against the four viral polymerases. The ethyl acetate extract exhibited a potent inhibitory effect against WNV's RdRp, with an IC₅₀ value of 8 µg mL⁻¹. The F₂ fraction exhibited potent inhibitory activity against WNV and HCV's RdRps, with IC₅₀ values 1 and 5 µg mL⁻¹, respectively. The P₂ fraction also showed potent inhibitory effects on WNV and HCV's RdRps, with IC₅₀ values 2.7 and 4 µg mL⁻¹, respectively. The results suggest that these extracts are candidates for the development of new anti-WNV RpDp and anti-HCV RpDp agents.
authors: Laboratoire de Chimie des Substances Naturelles, Faculté des Sciences de Sfax- BP 1171, 3000 Sfax, Tunisia.
authors: S
authors: S
authors: Miladi
authors: N
authors: N
authors: Abid
authors: C
authors: C
authors: Debarnôt
authors: M
authors: M
authors: Damak
authors: B
authors: B
authors: Canard
authors: M
authors: M
authors: Aouni
authors: B
authors: B
authors: Selmi
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D019661:Apiaceae / Q000737:chemistry* / Q000196:embryology; D003716:Dengue Virus / Q000187:drug effects; D015497:HIV-1 / Q000187:drug effects; D016174:Hepacivirus / Q000187:drug effects; D066298:In Vitro Techniques; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry*; D014902:West Nile virus / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D010936:Plant Extracts