title: Convergent intron loss of MRP1 in Drosophila and mosquito species.
abstract: Previous study revealed that the MRP1 gene ortholog DMRP1/CG6214 of Drosophila melanogaster contains 12 exons in the coding region. In the current study, the genes of DMRP1/CG6214 from D. melanogaster and Drosophila virilis were compared, and the result indicated that D. virilis had an extra intron located in exon 2, implying that intron loss or gain might have occurred at this locus. To track the evolution of the extra intron (Intron Z), orthologous nucleotide sequences of 37 arthropod species were cloned or annotated. Based on phylogenetic analysis, we found that Intron Z should present in the common ancestor of arthropod species, more than 420 Ma. In addition, we found that Sophophora subgenus species and mosquito (Culex pipiens) lost Intron Z independently, showing evolutionary convergence.
authors: Institute of Biochemistry, College of Life Sciences, Zhejiang University, People’s Republic of China.
authors: Lei-Lei
authors: LL
authors: Zhan
authors: Zhen
authors: Z
authors: Ding
authors: Yuan-Huai
authors: YH
authors: Qian
authors: Qing-Tao
authors: QT
authors: Zeng
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000818:Animals; D003465:Culex / Q000235:genetics*; D004330:Drosophila / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics*; D019143:Evolution, Molecular; D007438:Introns; D058977:Molecular Sequence Annotation; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D017384:Sequence Deletion
chemical_list: D018528:ATP-Binding Cassette Transporters; D029721:Drosophila Proteins; C495706:MRP protein, Drosophila