title: A study of anti-inflammatory and analgesic activity of new 2,4,6-trisubstituted pyrimidines.
abstract: Chalcone derivatives (3a-m) were prepared by condensing 4-aminoacetophenone with various substituted aromatic and hetero aromatic aldehydes according to Claisen-Schmidt condensation. These chalcones, on reaction with guanidine hydrochloride under basic alcoholic conditions gave 2,4,6-trisubstituted pyrimidines (5a-m) in quantitative yields. All the newly synthesized pyrimidines were characterized by means of IR, ¹H- and ¹³C-NMR, Electron Ionization (EI)-mass and elemental analyses and screened for anti-inflammatory and analgesic activities by in vivo. 2-amino-4-(4-aminophenyl)-6-(2,4-dichlorophenyl)pyrimidine (5b) and 2-amino-4-(4-aminophenyl)-6-(3-bromophenyl) pyrimidine (5d) were found to be the most potent anti-inflammatory and analgesic activity compared with ibuprofen, reference standard. And also it was found that compound 5b identified as lead structure among all in both the activities. Pyrimidines which showed good anti-inflammatory activity also displayed better analgesic activity.
authors: Pharmaceutical Chemistry Division, University College of Pharmaceutical Sciences, Andhra University, Andhra Pradesh, India.
authors: Rajendra Prasad
authors: RP
authors: Yejella
authors: Srinivasa Rao
authors: SR
authors: Atla
mesh_terms: D000284:Administration, Oral; D000700:Analgesics / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D002599:Chalcone / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D019791:Guanidine / Q000737:chemistry; D051379:Mice; D010146:Pain / Q000188:drug therapy; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: C568877:2-amino-4-(4-aminophenyl)-6-(2,4-dichlorophenyl)pyrimidine; C568878:2-amino-4-(4-aminophenyl)-6-(3-bromophenyl)pyrimidine; D000700:Analgesics; D000893:Anti-Inflammatory Agents; D011743:Pyrimidines; D002599:Chalcone; D019791:Guanidine; C030986:pyrimidine