title: Effect of dobutamine combined with intra-aortic balloon counterpulsation on left ventricular function early after acute myocardial infarction: experimental study.
abstract: Acute myocardial infarction (AMI) causes left ventricular (LV) remodeling, which forms the substrate for its early and late complications. The purpose of this study was to compare the acute effect of dobutamine or intra-aortic balloon pumping (IABP), alone or in combination, on LV function in the early phase of an experimental AMI. In 18 pigs, AMI was induced by ligation of the left anterior descending artery (LAD). IABP or dobutamine infusion at a rate of 5 µg/kg/min, or a combination of the two, was applied immediately after ligation of the LAD. Echocardiographic measurements of the long and short LV axes were obtained before (baseline) and post LAD ligation and at the end of each intervention for 5, 15, and 30 min. The fractional shortening (FS) of both axes, as well as the ejection fraction (EF), was calculated. The combination of dobutamine with IABP increased the EF significantly after the AMI in comparison to dobutamine or IABP alone, and improved the stroke volume, cardiac output, and long axis FS in comparison to IABP alone. Dobutamine alone produced a significantly higher increase of EF in comparison to IABP alone. These results indicate that the combination of dobutamine with IABP may be useful during AMI.
authors: Department of Clinical Therapeutics, Medical School, University of Athens, "Alexandra" Hospital, Athens, Greece. stouman@otenet.gr
authors: Savvas Th
authors: ST
authors: Toumanidis
authors: Nikolaos Tsirikos
authors: NT
authors: Karapanos
authors: George
authors: G
authors: Kottis
authors: Anna
authors: A
authors: Kaladaridou
authors: Dimitrios
authors: D
authors: Bramos
authors: Chrysanthi O
authors: CO
authors: Trikka
authors: Nikolaos
authors: N
authors: Vasiladiotis
authors: Nikolaos
authors: N
authors: Zakopoulos
authors: Spyridon D
authors: SD
authors: Moulopoulos
mesh_terms: D000818:Animals; D002302:Cardiac Output / Q000187:drug effects / Q000502:physiology; D002316:Cardiotonic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004280:Dobutamine / Q000494:pharmacology / Q000627:therapeutic use*; D006352:Heart Ventricles / Q000187:drug effects / Q000503:physiopathology* / Q000601:surgery; D007423:Intra-Aortic Balloon Pumping; D009203:Myocardial Infarction / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*; D013318:Stroke Volume / Q000187:drug effects / Q000502:physiology; D013552:Swine; D016896:Treatment Outcome; D016277:Ventricular Function, Left / Q000187:drug effects / Q000502:physiology
chemical_list: D002316:Cardiotonic Agents; D004280:Dobutamine