title: The vasculature in chagas disease.
abstract: The cardiovascular manifestations of Chagas disease are well known. However, the contribution of the vasculature and specifically the microvasculature has received little attention. This chapter reviews the evidence supporting the notion that alterations in the microvasculature especially in the heart contribute to the pathogenesis of chagasic cardiomyopathy. These data may also be important in understanding the contributions of the microvasculature in the aetiologies of other cardiomyopathies. The role of endothelin-1 and of thromboxane A(2) vascular spasm and platelet aggregation is also discussed. Further, these observations may provide target(s) for intervention.
authors: Department of Pathology, Laboratory of Cellular and Molecular Cardiology, University of São Paulo, Ribeirão Preto, Brazil.
authors: Cibele M
authors: CM
authors: Prado
authors: Linda A
authors: LA
authors: Jelicks
authors: Louis M
authors: LM
authors: Weiss
authors: Stephen M
authors: SM
authors: Factor
authors: Herbert B
authors: HB
authors: Tanowitz
authors: Marcos A
authors: MA
authors: Rossi
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000469:parasitology* / Q000473:pathology*; D002598:Chagas Cardiomyopathy / Q000469:parasitology* / Q000473:pathology*; D004285:Dogs; D019332:Endothelin-1 / Q000378:metabolism; D006801:Humans; D051379:Mice; D010974:Platelet Aggregation; D013928:Thromboxane A2 / Q000378:metabolism
chemical_list: D019332:Endothelin-1; D013928:Thromboxane A2