title: Actin stress fiber retraction and aggresome formation is a common cellular response to actin toxins.
abstract: F-actin-stabilizing drugs induce actin aggresome formation. In this study, we found that an actin-depolymerizing drug, latrunculin A (LatA), induced actin aggresomes. Actin stress fibers were retracted and disappeared in minutes, but a large aggresome formed in consequence of LatA treatment. Because cytochalasin D and mycalolide also induced aggresome formation, these results suggest that actin aggresome formation is a common cellular response to actin toxins.
authors: Chemical Library Validation Team, Chemical Biology Core Facility, RIKEN Advanced Science Institute, Saitama.
authors: Sayaka
authors: S
authors: Kazami
authors: Takeo
authors: T
authors: Usui
authors: Hiroyuki
authors: H
authors: Osada
mesh_terms: D000199:Actins / Q000378:metabolism*; D000818:Animals; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000009:adverse effects / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D015638:Cytochalasin D / Q000009:adverse effects / Q000494:pharmacology; D005347:Fibroblasts / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology*; D005354:Fibrosarcoma / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008387:Marine Toxins / Q000009:adverse effects / Q000494:pharmacology; D008856:Microscopy, Fluorescence; D018715:Microscopy, Video; D017510:Protein Folding / Q000187:drug effects*; D051381:Rats; D022502:Stress Fibers / Q000187:drug effects*; D013312:Stress, Physiological; D053778:Thiazolidines / Q000009:adverse effects / Q000494:pharmacology
chemical_list: D000199:Actins; D019086:Bridged Bicyclo Compounds, Heterocyclic; D008387:Marine Toxins; D053778:Thiazolidines; D015638:Cytochalasin D; C037067:latrunculin A