title: Amenorrhea complicating endoscopic third ventriculostomy in the pediatric age group.
abstract: Endoscopic third ventriculostomy (ETV) is an accepted option in the treatment of obstructive hydrocephalus in children and is considered by many pediatric neurosurgeons to be the treatment of choice in this population. The procedure involves perforation of the floor of the third ventricle, specifically, the tuber cinereum, which is part of the hypothalamic-pituitary axis of cerebral endocrine regulation. Endocrine dysfunction, such as amenorrhea, weight gain, and precocious puberty, which are recognized only months to years after the procedure, may be underreported because patients and physicians may not relate the endocrine sequelae to the ETV. Few detailed reports of endocrine-related complications following ETV exist to better understand these issues. In this study, the authors add to the literature with case descriptions of and correlative laboratory findings in 2 adolescent girls who underwent ETV for obstructive hydrocephalus and in whom amenorrhea subsequently developed.
authors: Division of Pediatric Neurosurgery, Texas Children's Hospital, Department of Neurosurgery, Baylor College of Medicine, Houston, Texas 77030, USA.
authors: Steven W
authors: SW
authors: Hwang
authors: George
authors: G
authors: Al-Shamy
authors: William E
authors: WE
authors: Whitehead
authors: Daniel J
authors: DJ
authors: Curry
authors: Robert
authors: R
authors: Dauser
authors: Thomas G
authors: TG
authors: Luerssen
authors: Andrew
authors: A
authors: Jea
mesh_terms: D000293:Adolescent; D000568:Amenorrhea / Q000209:etiology*; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000473:pathology / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D044583:Neuroendoscopy; D011183:Postoperative Complications / Q000209:etiology*; D020542:Third Ventricle / Q000601:surgery; D014696:Ventriculostomy / Q000009:adverse effects*