title: [Impact of herpesvirus infections on the level of proinflammatory cytokines in premature neonatal infants].
abstract: The aim of this study was to estimate the frequency of HSV and/or CMV among the pathogens causing intrauterine infections (IUI) and to investigate their impact on the level of proinflammatory cytokines in premature neonatal infants. Examinations were performed in 3 neonatal groups: 1) premature neonates with clinical manifestations of IUI; 2) those without IUI; 3) full-term newborns. In group 1, viral (HSV and/or CMV) and bacterial infections were detectable with the same frequency. Quantitative analysis of plasma IL-6 and IL-8 levels and the induced production of these cytokines by blood cells in vitro showed that in Group 1 neonates, IL-6 and IL-8 concentrations were substantially higher and the induced production of these cytokines was lowerthan those in Group 3. The detection of HSV and/or CMV markers in premature newborn infants was attended by a statistically significant rise in plasma IL-6 levels; the identification of the opportunistic bacterial microflora correlated with the higher concentration of IL-8. In Group 1, wiferon produced an immunomodulatory effect, by lowering IL-8 concentrations to the level observed in Group 3.
authors: R R
authors: RR
authors: Klimova
authors: V V
authors: VV
authors: Malinovskaia
authors: T S
authors: TS
authors: Guseva
authors: O V
authors: OV
authors: Parshina
authors: E G
authors: EG
authors: Getiia
authors: M V
authors: MV
authors: Degtiareva
authors: I G
authors: IG
authors: Soldatova
authors: N N
authors: NN
authors: Volodin
authors: Z S
authors: ZS
authors: Gadzhieva
authors: A S
authors: AS
authors: Tsibizov
authors: A A
authors: AA
authors: Kushch
mesh_terms: D015415:Biomarkers / Q000097:blood; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000276:immunology / Q000628:therapy; D006566:Herpesviridae Infections / Q000276:immunology / Q000628:therapy; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage / Q000627:therapeutic use*; D016899:Interferon-beta / Q000097:blood / Q000652:urine; D015850:Interleukin-6 / Q000097:blood / Q000652:urine; D016209:Interleukin-8 / Q000097:blood / Q000652:urine; D007962:Leukocytes / Q000276:immunology / Q000378:metabolism; D011994:Recombinant Proteins; D018139:Simplexvirus / Q000276:immunology; D013488:Suppositories / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D015415:Biomarkers; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D015850:Interleukin-6; D016209:Interleukin-8; D011994:Recombinant Proteins; D013488:Suppositories; D016899:Interferon-beta