title: Preimplantation exposure to bisphenol A (BPA) affects embryo transport, preimplantation embryo development, and uterine receptivity in mice.
abstract: To investigate the effects of bisphenol A (BPA) on embryo and uterine factors in embryo implantation, timed pregnant C57BL6 females were treated subcutaneously with 0, 0.025, 0.5, 10, 40, and 100mg/kg/day BPA from gestation days 0.5-3.5. In 100mg/kg/day BPA-treated females, no implantation sites were detected on day 4.5 but retention of embryos in the oviduct and delayed embryo development were detected on day 3.5. When untreated healthy embryos were transferred to pseudopregnant females treated with 100mg/kg/day BPA, no implantation sites were detected on day 4.5. In 40 mg/kg/day BPA-treated females, delayed implantation and increased perinatal lethality of their offspring were observed. Implantation seemed normal in the rest BPA-treated groups or the female offspring from 40 mg/kg/day BPA-treated group. These data demonstrate the adverse effects of high doses of BPA on processes critical for embryo implantation: embryo transport, preimplantation embryo development, and establishment of uterine receptivity.
authors: Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA. shuoxiao@uga.edu
authors: Shuo
authors: S
authors: Xiao
authors: Honglu
authors: H
authors: Diao
authors: Mary Alice
authors: MA
authors: Smith
authors: Xiao
authors: X
authors: Song
authors: Xiaoqin
authors: X
authors: Ye
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds; D001755:Blastocyst / Q000187:drug effects* / Q000502:physiology*; D010064:Embryo Implantation / Q000187:drug effects*; D004624:Embryo Transfer; D047108:Embryonic Development / Q000187:drug effects*; D004968:Estrogens, Non-Steroidal / Q000633:toxicity; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D010636:Phenols / Q000008:administration & dosage / Q000633:toxicity*; D011247:Pregnancy; D014599:Uterus / Q000187:drug effects* / Q000502:physiology; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004968:Estrogens, Non-Steroidal; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds