title: Fluid overload deteriorate chylothorax: evaluation in a canine model.
abstract: No conservative treatments for chylothorax have yet been established, and surgical ligation of the thoracic duct is required in many cases. In the present study, we investigated the management of body fluid in a canine chylothorax model. Twelve beagle dogs were divided evenly into three groups: A, B, and C. Under general anesthesia, the thoracic duct was cut and opened, and the amount of lymph fluid leakage was measured. Intravenous extracellular fluid infusion was started at 5mL/kg/h for the first 2h, and then between 2 and 4h, the infusion rate was increased to 10 mL/kg/h in group A and to 20mL/kg/h in group B. During the first 2h after cutting the thoracic duct, the mean lymph fluid leakage rates in groups A, B, and C were 0.466, 0.635, and 0.575 mL/kg/h, respectively. The rates of leakage did not differ significantly among the groups. Between 2 and 4h, the mean rates of leakage were 0.750, 1.43, and 0.544mL/kg/h, respectively, being significantly higher in groups A and B than in group C. The amount of lymph fluid ascending the thoracic duct correlates with the amount of intravenous fluid infusion. For the management of chylothorax, it is important to avoid fluid overload.
authors: Department of Bioartificial Organs, Institute for Frontier Medical Science, Kyoto University, Kyoto, Japan. mhonda@frontier.kyoto-u.ac.jp
authors: M
authors: M
authors: Honda
authors: Y
authors: Y
authors: Hori
authors: Y
authors: Y
authors: Shionoya
authors: K
authors: K
authors: Yamamoto
authors: F
authors: F
authors: Kojima
authors: T
authors: T
authors: Nakamura
mesh_terms: D000818:Animals; D002913:Chyle / Q000378:metabolism*; D002916:Chylothorax / Q000209:etiology; D004285:Dogs; D005440:Fluid Therapy / Q000009:adverse effects*; D007208:Indocyanine Green / Q000008:administration & dosage; D007262:Infusions, Intravenous; D023421:Models, Animal; D013897:Thoracic Duct / Q000378:metabolism
chemical_list: D007208:Indocyanine Green