title: Malignant tumor-like gastric lesion due to Candida albicans in a diabetic patient treated with cyclosporin: a case report and review of the literature.
abstract: The gastrointestinal tract of healthy individuals is colonized by hundreds of saprophytes and mycetes, especially the Candida species, are habitual ones. Under certain conditions, the fungal flora may overgrow, resulting in lesions of the digestive mucosa which, rarely, can have a local diffusion and/or spread to the lympho-hematogenous system. Mycotic infections of the stomach can sometimes look like benign gastric ulcers. Here, we present the case report of a woman, aged 64, who presented with type II diabetes mellitus and psoriasis, on chronic treatment with cyclosporin A and with endoscopic evidence of an ulcerated, vegetating gastric lesion secondary to Candida albicans infection. Although strongly suggestive of malignancy, it completely healed after cyclosporin withdrawal and the administration of oral antifungal drugs.
authors: Internal Medicine, Department of Clinical Medicine and Emerging Diseases, University Hospital of Palermo, Via del Vespro, 141-90146, Palermo, Italy. pasquale.mansueto@unipa.it
authors: Pasquale
authors: P
authors: Mansueto
authors: Giuseppe
authors: G
authors: Pisciotta
authors: Giovanni
authors: G
authors: Tomasello
authors: Daniela
authors: D
authors: Cabibi
authors: Aurelio
authors: A
authors: Seidita
authors: Alberto
authors: A
authors: D'Alcamo
authors: Angelo Maria
authors: AM
authors: Patti
authors: Delia
authors: D
authors: Sprini
authors: Antonio
authors: A
authors: Carroccio
authors: Giovam Battista
authors: GB
authors: Rini
authors: Gaetana Di
authors: GD
authors: Fede
mesh_terms: D000935:Antifungal Agents / Q000009:adverse effects / Q000627:therapeutic use; D002176:Candida albicans / Q000302:isolation & purification / Q000472:pathogenicity*; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008875:Middle Aged; D013276:Stomach Ulcer / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D016572:Cyclosporine