title: Lower production of IL-17A and increased susceptibility to Mycobacterium bovis in mice coinfected with Strongyloides venezuelensis.
abstract: The presence of intestinal helminths can down-regulate the immune response required to control mycobacterial infection. BALB/c mice infected with Mycobacterium bovis following an infection with the intestinal helminth Strongyloides venezuelensis showed reduced interleukin-17A production by lung cells and increased bacterial burden. Also, small granulomas and a high accumulation of cells expressing the inhibitory molecule CTLA-4 were observed in the lung. These data suggest that intestinal helminth infection could have a detrimental effect on the control of tuberculosis (TB) and render coinfected individuals more susceptible to the development of TB.
authors: Departamento de Parasitologia, Microbiologia e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brasil, 36036-330.
authors: Alyria Teixeira
authors: AT
authors: Dias
authors: Sandra Bertelli Ribeiro
authors: SB
authors: de Castro
authors: Caio César Souza
authors: CC
authors: Alves
authors: Alice Belleigoli
authors: AB
authors: Rezende
authors: Michele Fernandes
authors: MF
authors: Rodrigues
authors: Rachel Rocha Pinheiro
authors: RR
authors: Machado
authors: Adriana
authors: A
authors: Fernandes
authors: Deborah
authors: D
authors: Negrão-Corrêa
authors: Henrique Couto
authors: HC
authors: Teixeira
authors: Ana Paula
authors: AP
authors: Ferreira
mesh_terms: D000818:Animals; D058491:Bacterial Load / Q000379:methods; D060085:Coinfection / Q000150:complications / Q000276:immunology / Q000473:pathology; D004198:Disease Susceptibility; D020381:Interleukin-17 / Q000096:biosynthesis*; D007411:Intestinal Diseases, Parasitic / Q000150:complications / Q000276:immunology* / Q000473:pathology; D008168:Lung / Q000382:microbiology / Q000469:parasitology; D051379:Mice; D008807:Mice, Inbred BALB C; D009164:Mycobacterium Infections / Q000150:complications / Q000276:immunology* / Q000473:pathology; D009163:Mycobacterium bovis / Q000276:immunology*; D013321:Strongyloides / Q000276:immunology*; D013322:Strongyloidiasis / Q000150:complications / Q000276:immunology* / Q000473:pathology
chemical_list: D020381:Interleukin-17