title: Inhibition of aminoglycoside-deactivating enzymes APH(3')-IIIa and AAC(6')-Ii by amphiphilic paromomycin O2''-ether analogues.
authors: Department of Chemistry, Université de Montréal, C. P. 6128, Succ. Centre-Ville, Montréal, QC, H3C 3J7, Canada.
authors: Janek
authors: J
authors: Szychowski
authors: Jiro
authors: J
authors: Kondo
authors: Omar
authors: O
authors: Zahr
authors: Karine
authors: K
authors: Auclair
authors: Eric
authors: E
authors: Westhof
authors: Stephen
authors: S
authors: Hanessian
authors: Jeffrey W
authors: JW
authors: Keillor
mesh_terms: D000123:Acetyltransferases / Q000037:antagonists & inhibitors; D040981:Acinetobacter baumannii / Q000187:drug effects; D000583:Amikacin / Q000378:metabolism; D000617:Aminoglycosides / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D019868:Kanamycin Kinase / Q000037:antagonists & inhibitors*; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010303:Paromomycin / Q000031:analogs & derivatives*; D012270:Ribosomes / Q000187:drug effects / Q000378:metabolism; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D010303:Paromomycin; D000583:Amikacin; D000123:Acetyltransferases; C056532:aminoglycoside N(6')-acetyltransferase; D019868:Kanamycin Kinase