title: Large-scale brain networks and psychopathology: a unifying triple network model.
abstract: The science of large-scale brain networks offers a powerful paradigm for investigating cognitive and affective dysfunction in psychiatric and neurological disorders. This review examines recent conceptual and methodological developments which are contributing to a paradigm shift in the study of psychopathology. I summarize methods for characterizing aberrant brain networks and demonstrate how network analysis provides novel insights into dysfunctional brain architecture. Deficits in access, engagement and disengagement of large-scale neurocognitive networks are shown to play a prominent role in several disorders including schizophrenia, depression, anxiety, dementia and autism. Synthesizing recent research, I propose a triple network model of aberrant saliency mapping and cognitive dysfunction in psychopathology, emphasizing the surprising parallels that are beginning to emerge across psychiatric and neurological disorders.
authors: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanfod, CA 94305, USA. menon@stanford.edu
authors: Vinod
authors: V
authors: Menon
mesh_terms: D001921:Brain / Q000473:pathology*; D006801:Humans; D008959:Models, Neurological; D009415:Nerve Net / Q000473:pathology*; D011599:Psychopathology / Q000379:methods