title: Sensing damage by the NLRP3 inflammasome.
abstract: The NLRP3 inflammasome is activated in response to a variety of signals that are indicative of damage to the host including tissue damage, metabolic stress, and infection. Upon activation, the NLRP3 inflammasome serves as a platform for activation of the cysteine protease caspase-1, which leads to the processing and secretion of the proinflammatory cytokines interleukin-1β (IL-1β) and IL-18. Dysregulated NLRP3 inflammasome activation is associated with both heritable and acquired inflammatory diseases. Here, we review new insights into the mechanism of NLRP3 inflammasome activation and its role in disease pathogenesis.
authors: Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors: Jaklien C
authors: JC
authors: Leemans
authors: Suzanne L
authors: SL
authors: Cassel
authors: Fayyaz S
authors: FS
authors: Sutterwala
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D002352:Carrier Proteins / Q000276:immunology*; D020169:Caspases / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D007239:Infections / Q000276:immunology*; D058847:Inflammasomes / Q000276:immunology*; D007249:Inflammation; D020382:Interleukin-18 / Q000276:immunology; D053583:Interleukin-1beta / Q000276:immunology*; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D013312:Stress, Physiological / Q000276:immunology
chemical_list: D002352:Carrier Proteins; D058847:Inflammasomes; D020382:Interleukin-18; D053583:Interleukin-1beta; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human; D020169:Caspases