title: Human papillomavirus type-specific risk of cervical cancer in a population with high human immunodeficiency virus prevalence: case-control study.
abstract: There are limited data on human papillomavirus (HPV) type-specific cervical cancer risk among human immunodeficiency virus (HIV)-positive women. Previous studies have suggested that HPV 16 would be relatively less important as a causative agent among HIV-positive compared with HIV-negative women. This study investigates HPV type-specific cervical cancer risk in a population in which HIV is endemic. At the Central Hospital, Maputo, Mozambique, 221 cervical cancer cases and 203 hospital-based controls were consecutively enrolled. HPV typing from cervical samples, HIV testing and recording of socio-demographic factors were performed. Logistic regression modelling was used to assess HPV type-specific risk and effect modification between HIV and HPV infection. Infection with HPV 16, 18 and 'high-risk non-HPV 16/18 types' (HPV 31, 33, 35, 39, 45, 51, 52, 56, 58 and 59) was associated with cervical cancer in both crude and adjusted analyses. HPV 16 and 18 were the most common types detected in cancer biopsies among both HIV-negative and HIV-positive women. There was no significant evidence of effect modification between any HPV type and HIV infection, and there were no significant differences in the HPV type-specific prevalence when cervical cancers among HIV-positive and HIV-negative women were compared. Within the limitations of the study, the relative importance of different HPV types in cervical carcinogenesis appears not to be modified greatly by HIV infection, suggesting that HPV vaccines might not need to be type-specifically modified to be suitable for populations where HIV is endemic.
authors: Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
authors: Pontus
authors: P
authors: Naucler
authors: Department of Obstetrics and Gynecology, Central Hospital, Maputo, Mozambique.
authors: Flora
authors: F
authors: Mabota da Costa
authors: Department of Otolaryngology, Central Hospital Maputo, Mozambique.
authors: Joao Leopoldo
authors: JL
authors: da Costa
authors: Department of Pathology, University Hospital Malmö, Lund University, Sweden.
authors: Otto
authors: O
authors: Ljungberg
authors: Department of Obstetrics and Gynecology, Central Hospital, Maputo, Mozambique.
authors: Antonio
authors: A
authors: Bugalho
authors: Department of Medical Microbiology, Malmö University Hospital, Lund University and Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
authors: Joakim
authors: J
authors: Dillner
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002584:Cervix Uteri / Q000737:chemistry / Q000821:virology; D004279:DNA, Viral; D005260:Female; D006678:HIV / Q000378:metabolism / Q000472:pathogenicity; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology*; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D009073:Mozambique / Q000453:epidemiology; D015999:Multivariate Analysis; D027383:Papillomaviridae / Q000235:genetics*; D030361:Papillomavirus Infections / Q000150:complications / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors; D012959:Socioeconomic Factors; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000821:virology*
chemical_list: D004279:DNA, Viral