title: Regioselectivity in the ring opening of non-activated aziridines.
abstract: In this critical review, the ring opening of non-activated 2-substituted aziridines via intermediate aziridinium salts will be dealt with. Emphasis will be put on the relationship between the observed regioselectivity and inherent structural features such as the nature of the C2 aziridine substituent and the nature of the electrophile and the nucleophile. This overview should allow chemists to gain insight into the factors governing the regioselectivity in aziridinium ring openings (81 references).
authors: Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium.
authors: Sonja
authors: S
authors: Stanković
authors: Matthias
authors: M
authors: D'hooghe
authors: Saron
authors: S
authors: Catak
authors: Heesung
authors: H
authors: Eum
authors: Michel
authors: M
authors: Waroquier
authors: Veronique
authors: V
authors: Van Speybroeck
authors: Norbert
authors: N
authors: De Kimpe
authors: Hyun-Joon
authors: HJ
authors: Ha
mesh_terms: D000478:Alkylation; D001388:Aziridines / Q000737:chemistry*; D058116:Lewis Acids / Q000737:chemistry; D011522:Protons; D013237:Stereoisomerism
chemical_list: D001388:Aziridines; D058116:Lewis Acids; D011522:Protons