title: Molecular mechanisms of l-DOPA-induced dyskinesia.
abstract: Parkinson's disease (PD), a common neurodegenerative disorder caused by the loss of the dopaminergic input to the basal ganglia, is commonly treated with l-DOPA. Use of this drug, however, is severely limited by the development of dystonic and choreic motor complications, or dyskinesia. This chapter describes the molecular mechanisms implicated in the emergence and manifestation of l-DOPA-induced dyskinesia (LID). Particular emphasis is given to the role played in this condition by abnormalities in signal transduction at the level of the medium spiny neurons (MSNs) of the striatum, which are the principal target of l-DOPA. Recent evidence pointing to pre-synaptic dysregulation is also discussed.
authors: Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.
authors: Gilberto
authors: G
authors: Fisone
authors: Erwan
authors: E
authors: Bezard
mesh_terms: D000547:Amantadine / Q000627:therapeutic use; D000818:Animals; D000978:Antiparkinson Agents / Q000009:adverse effects*; D001479:Basal Ganglia / Q000473:pathology; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics* / Q000473:pathology; D017781:Genes, Immediate-Early / Q000502:physiology; D006801:Humans; D007980:Levodopa / Q000009:adverse effects*; D009474:Neurons / Q000473:pathology / Q000648:ultrastructure; D010300:Parkinson Disease / Q000188:drug therapy; D043884:Receptor, Cannabinoid, CB1 / Q000235:genetics / Q000378:metabolism; D011954:Receptors, Dopamine / Q000235:genetics / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics / Q000378:metabolism; D011985:Receptors, Serotonin / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D020123:Sirolimus / Q000378:metabolism
chemical_list: D000978:Antiparkinson Agents; D043884:Receptor, Cannabinoid, CB1; D011954:Receptors, Dopamine; D016194:Receptors, N-Methyl-D-Aspartate; D011985:Receptors, Serotonin; D007980:Levodopa; D000547:Amantadine; D020123:Sirolimus