title: Short hairpin RNA screen reveals bromodomain proteins as novel targets in acute myeloid leukemia.
abstract: Targeting chromatin regulators for the treatment of malignancies has shown great promise, but also revealed significant challenges. By employing an elegant shRNA screen and a selective pharmacological inhibitor, a recent study published in Nature establishes the bromodomain protein Brd4 as novel target in acute myeloid leukemia (AML).
authors: Division of Hematology, The Children's Hospital of Philadelphia, PA 19104, USA.
authors: Gerd A
authors: GA
authors: Blobel
authors: Anna
authors: A
authors: Kalota
authors: Patricia V
authors: PV
authors: Sanchez
authors: Martin
authors: M
authors: Carroll