title: [The role of uric acid in heart failure].
abstract: Complications and mortality of heart failure are high, despite the availability of several forms of treatment. Uric acid, the end product of purine metabolism would actively participate in the pathophysiology of heart failure. However, there is no consensus about its action in cardiovascular disease. Serum uric acid would have a protective antioxidant activity. This action could help to reduce or counteract the processes that cause or appear as a result of heart failure. However, these protective properties would vanish in the intracellular environment or in highly hydrophobic areas such as atherosclerotic plaques and adipose tissue. This review discusses the paradoxical action of uric acid in the pathophysiology of heart failure.
authors: Escuela de Medicina, Campus San Felipe, Universidad de Valparaíso, San Felipe, Chile.
authors: Hernán
authors: H
authors: Alcaíno
authors: Douglas
authors: D
authors: Greig
authors: Pablo
authors: P
authors: Castro
authors: Hugo
authors: H
authors: Verdejo
authors: Rosemarie
authors: R
authors: Mellado
authors: Lorena
authors: L
authors: García
authors: Guillermo
authors: G
authors: Díaz-Araya
authors: Clara
authors: C
authors: Quiroga
authors: Mario
authors: M
authors: Chiong
authors: Sergio
authors: S
authors: Lavandero
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D006333:Heart Failure / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology*; D014527:Uric Acid / Q000097:blood*; D014969:Xanthine Oxidase / Q000502:physiology*
chemical_list: D015415:Biomarkers; D014527:Uric Acid; D014969:Xanthine Oxidase