title: Comparative analysis of the nuclear presence of adhesion/growth-regulatory galectins and reactivity in the nuclei of interphasic and mitotic cells.
abstract: Nuclear galectins participate in splicing of pre-mRNA. In this study we detected galectins-1, -2, -3 and -7 and their glycoligands in three types of cells: fibroblasts, cancer epithelial cells and melanoma cells. The results demonstrated that the nuclear expression of distinct types of galectins and their ligands in interphasic nuclei is dependent on the cell type. The extensive binding of labelled galectins-1 and -2 to mitotic cells (around chromosomes, in mitotic spindle and in bridge connecting both daughter cells) suggests their role during the cell division.
authors: Institute of Anatomy, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
authors: O
authors: O
authors: Kodet
authors: B
authors: B
authors: Dvořánková
authors: L
authors: L
authors: Lacina
authors: S
authors: S
authors: André
authors: H
authors: H
authors: Kaltner
authors: H-J
authors: HJ
authors: Gabius
authors: K
authors: K
authors: Smetana
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism; D045744:Cell Line, Tumor; D002467:Cell Nucleus / Q000378:metabolism*; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D037483:Galectin 1; D037161:Galectins / Q000378:metabolism*; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D007399:Interphase / Q000502:physiology*; D008024:Ligands; D008544:Melanocytes / Q000166:cytology / Q000378:metabolism; D008545:Melanoma / Q000378:metabolism; D008938:Mitosis / Q000502:physiology*; D009369:Neoplasms / Q000378:metabolism
chemical_list: D015815:Cell Adhesion Molecules; D037483:Galectin 1; D037161:Galectins; D006133:Growth Substances; D008024:Ligands