title: Tropheryma whipplei aortic valve endocarditis without systemic Whipple's disease.
abstract: Culture-negative endocarditis is most often the result of prior antimicrobial therapy. Tropheryma whipplei is the etiologic agent of Whipple's disease, which is typically characterized by diarrhea, weight loss, and intra-abdominal lymphadenopathy. We present the case of a 48-year-old male with Whipple's endocarditis of the aortic valve who did not develop signs of systemic Whipple's disease. Our patient was treated with a regimen that included ceftriaxone for 6 weeks prior to his cardiac surgery, yet valve pathology demonstrated abundant T. whipplei, suggesting that a prolonged antibiotic course is necessary for the treatment of Whipple's endocarditis.
authors: Division of Cardiac Surgery, The University of Ottawa Heart Institute, University of Ottawa, 40 Ruskin Street, Suite H3402, Ottawa, Ontario K1Y4W7, Canada.
authors: Vincent
authors: V
authors: Chan
authors: Bing
authors: B
authors: Wang
authors: John P
authors: JP
authors: Veinot
authors: Kathryn N
authors: KN
authors: Suh
authors: Gregory
authors: G
authors: Rose
authors: Marc
authors: M
authors: Desjardins
authors: Thierry G
authors: TG
authors: Mesana
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001021:Aortic Valve / Q000473:pathology; D002443:Ceftriaxone / Q000008:administration & dosage / Q000627:therapeutic use*; D004697:Endocarditis, Bacterial / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control; D006349:Heart Valve Diseases / Q000175:diagnosis*; D006801:Humans; D008206:Lymphatic Diseases / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D054851:Tropheryma / Q000187:drug effects / Q000302:isolation & purification*; D008061:Whipple Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control
chemical_list: D000900:Anti-Bacterial Agents; D002443:Ceftriaxone