title: Recombination gives a new insight in the effective population size and the history of the old world human populations.
abstract: The information left by recombination in our genomes can be used to make inferences on our recent evolutionary history. Specifically, the number of past recombination events in a population sample is a function of its effective population size (Ne). We have applied a method, Identifying Recombination in Sequences (IRiS), to detect specific past recombination events in 30 Old World populations to infer their Ne. We have found that sub-Saharan African populations have an Ne that is approximately four times greater than those of non-African populations and that outside of Africa, South Asian populations had the largest Ne. We also observe that the patterns of recombinational diversity of these populations correlate with distance out of Africa if that distance is measured along a path crossing South Arabia. No such correlation is found through a Sinai route, suggesting that anatomically modern humans first left Africa through the Bab-el-Mandeb strait rather than through present Egypt.
authors: Marta
authors: M
authors: Melé
authors: Asif
authors: A
authors: Javed
authors: Marc
authors: M
authors: Pybus
authors: Pierre
authors: P
authors: Zalloua
authors: Marc
authors: M
authors: Haber
authors: David
authors: D
authors: Comas
authors: Mihai G
authors: MG
authors: Netea
authors: Oleg
authors: O
authors: Balanovsky
authors: Elena
authors: E
authors: Balanovska
authors: Li
authors: L
authors: Jin
authors: Yajun
authors: Y
authors: Yang
authors: R M
authors: RM
authors: Pitchappan
authors: G
authors: G
authors: Arunkumar
authors: Laxmi
authors: L
authors: Parida
authors: Francesc
authors: F
authors: Calafell
authors: Jaume
authors: J
authors: Bertranpetit
mesh_terms: D000349:Africa; D001208:Asia; D030541:Databases, Genetic; D005060:Europe; D019143:Evolution, Molecular; D049690:History, Ancient; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011156:Population Density; D044469:Racial Groups / Q000235:genetics* / Q000266:history*; D011995:Recombination, Genetic; D018709:Statistics, Nonparametric