title: Pattern of MHC class I and immune proteasome expression in Walker 256 tumor during growth and regression in Brattleboro rats with the hereditary defect of arginine-vasopressin synthesis.
abstract: Dynamics of the expression of MHC class I, immune proteasomes and proteasome regulators 19S, PA28, total proteasome pool and proteasome chymotrypsin-like activity in Walker 256 tumor after implantation into Brattleboro rats with the hereditary defect of arginine-vasopressin synthesis was studied. The tumor growth and regression in Brattleboro rats were accompanied by changes in the proteasome subunit level unlike the tumor growth in WAG rats with normal expression of arginine-vasopressin gene. In the tumor implanted into Brattleboro rats the immune proteasome level was maximal between days 14 and 17, when the tumor underwent regression. Conversely, the expression of proteasome regulators tended to decrease during this period. Immune proteasomes are known to produce antigen epitopes for MHC class I to be presented to CD8+ T lymphocytes. Enhanced expression of immune proteasomes coincided with the recovery of MHC class I expression, suggesting the efficient presentation of tumor antigens in Brattleboro rats.
authors: NK Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia.
authors: Liudmila A
authors: LA
authors: Zakharova
authors: Igor I
authors: II
authors: Khegai
authors: Natalia P
authors: NP
authors: Sharova
authors: Victoria I
authors: VI
authors: Melnikova
authors: Yaroslava D
authors: YD
authors: Karpova
authors: Tatiana M
authors: TM
authors: Astakhova
authors: Nelly A
authors: NA
authors: Popova
authors: Liudmila N
authors: LN
authors: Ivanova
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D000951:Antigens, Neoplasm / Q000378:metabolism; D001127:Arginine Vasopressin / Q000096:biosynthesis / Q000235:genetics*; D002279:Carcinoma 256, Walker / Q000235:genetics* / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D002918:Chymotrypsin / Q000276:immunology / Q000378:metabolism; D003546:Cysteine Endopeptidases / Q000276:immunology / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D008297:Male; D009365:Neoplasm Regression, Spontaneous / Q000235:genetics / Q000276:immunology; D009368:Neoplasm Transplantation; D046988:Proteasome Endopeptidase Complex / Q000276:immunology* / Q000378:metabolism; D051381:Rats; D011910:Rats, Brattleboro
chemical_list: D000951:Antigens, Neoplasm; D015395:Histocompatibility Antigens Class I; D001127:Arginine Vasopressin; C071313:LMP-2 protein; D002918:Chymotrypsin; D003546:Cysteine Endopeptidases; C077436:LMP7 protein; D046988:Proteasome Endopeptidase Complex