title: Injection-site reactions upon Kineret (anakinra) administration: experiences and explanations.
abstract: Anakinra (Kineret), a recombinant form of human interleukin-1 (IL-1) receptor antagonist, is approved for the treatment of rheumatoid arthritis (RA) in combination with methotrexate. Kineret is self-administered by daily subcutaneous injections in patients with active RA. The mechanism of action of anakinra is to competitively inhibit the local inflammatory effects of IL-1. Kineret is generally safe and well tolerated and the only major treatment-related side effects that appear are skin reactions at the injection site. Due to the relatively short half-life of anakinra, daily injection of the drug is required. This, in combination with the comparably high rates of injection-site reactions (ISRs) associated with the drug, can become a problem for the patient. The present review summarises published data concerning ISRs associated with Kineret and provides some explanations as to their cause. The objective is also to present some clinical experiences of how the ISRs can be managed.
authors: Swedish Orphan Biovitrum AB, 11276 Stockholm, Sweden. Christina.Kaiser@sobi.com
authors: Christina
authors: C
authors: Kaiser
authors: Ann
authors: A
authors: Knight
authors: Dan
authors: D
authors: Nordström
authors: Tom
authors: T
authors: Pettersson
authors: Jonas
authors: J
authors: Fransson
authors: Ebba
authors: E
authors: Florin-Robertsson
authors: Björn
authors: B
authors: Pilström
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D003875:Drug Eruptions / Q000188:drug therapy / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D007279:Injections, Subcutaneous / Q000009:adverse effects / Q000379:methods / Q000592:standards; D053590:Interleukin 1 Receptor Antagonist Protein / Q000008:administration & dosage* / Q000009:adverse effects*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D053590:Interleukin 1 Receptor Antagonist Protein