title: Highly enantioselective γ-amination of α,β-unsaturated acyl chlorides with azodicarboxylates: efficient synthesis of chiral γ-amino acid derivatives.
abstract: The cinchona alkaloid-catalyzed γ-amination of α,β-unsaturated acyl chlorides with azodicarboxylates to give the corresponding dihydropyridazinones in good yields with high enantioselectivities has been developed. Reductive ring opening of the dihydropyridazinones afforded series of cyclic and acyclic γ-amino acid derivatives in good yields with high enantiopurity.
authors: Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors: Li-Tao
authors: LT
authors: Shen
authors: Li-Hui
authors: LH
authors: Sun
authors: Song
authors: S
authors: Ye
mesh_terms: D000586:Amination; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry*; D002930:Cinchona Alkaloids / Q000737:chemistry*; D011724:Pyridazines / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D002264:Carboxylic Acids; D002712:Chlorides; D002930:Cinchona Alkaloids; D011724:Pyridazines