title: Glomerular filtration rate in early diabetes: ongoing discussions of causes and mechanisms.
abstract: Glomerular hyperfiltration (>140 ml/min per 1.73 m2 body surface area) is found in early diabetes and is associated with a poor prognosis with respect to the development of diabetic kidney disease. This review addresses recent investigations and discussions of the following hypotheses behind diabetic hyperfiltration: Increased proximal tubular volume reabsorption results in a pressure drop in Bowman's capsule which increases glomerular filtration rate (GFR). Proximal tubular hyperreabsorption induces an increase in GFR mediated by tubuloglomerular feedback. Dietary NaCl restriction results in a paradoxically increased GFR and increased urine volume in diabetic animals.
authors: The Water and Salt Research Center, University of Aarhus, Aarhus C, Denmark. sfri@ana.au.dk
authors: Sebastian
authors: S
authors: Frische
mesh_terms: D000818:Animals; D003928:Diabetic Nephropathies / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D018450:Disease Progression; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000503:physiopathology*; D011379:Prognosis; D012307:Risk Factors; D017673:Sodium Chloride, Dietary / Q000378:metabolism; D013997:Time Factors
chemical_list: D017673:Sodium Chloride, Dietary