title: Diverse organo-peptide macrocycles via a fast and catalyst-free oxime/intein-mediated dual ligation.
abstract: Macrocyclic Organo-Peptide Hybrids (MOrPHs) can be prepared from genetically encoded polypeptides via a chemoselective and catalyst-free reaction between a trifunctional oxyamino/amino-thiol synthetic precursor and an intein-fusion protein incorporating a bioorthogonal keto group.
authors: Department of Chemistry, University of Rochester, Rochester, NY, USA.
authors: Maragani
authors: M
authors: Satyanarayana
authors: Francesca
authors: F
authors: Vitali
authors: John R
authors: JR
authors: Frost
authors: Rudi
authors: R
authors: Fasan
mesh_terms: D047668:Inteins; D047028:Macrocyclic Compounds / Q000737:chemistry*; D015394:Molecular Structure; D010091:Oximes / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*
chemical_list: D047028:Macrocyclic Compounds; D010091:Oximes; D010455:Peptides