title: Effects of intravenous administration of lactated Ringer's solution on hematologic, serum biochemical, rheological, hemodynamic, and renal measurements in healthy isoflurane-anesthetized dogs.
abstract: OBJECTIVE
  To determine the hematologic, serum biochemical, rheological, hemodynamic, and renal effects of IV administration of lactated Ringer's solution (LRS) to healthy anesthetized dogs.
  
  
  METHODS
  4-period, 4-treatment cross-over study.
  
  
  METHODS
  8 healthy mixed-breed dogs.
  
  
  METHODS
  Each dog was anesthetized, mechanically ventilated, instrumented, and randomly assigned to receive LRS (0, 10, 20, or 30 mL/kg/h [0, 4.5, 9.1, or 13.6 mL/lb/h]), IV, on 4 occasions separated by at least 7 days. Blood hemoglobin concentration and serum total protein, albumin, lactate, and electrolyte concentrations; PCV; colloid osmotic pressure; arterial and venous pH and blood gases (Po2; Pco2); whole blood and plasma viscosity; arterial and venous blood pressures; cardiac output; results of urinalysis; urine production; glomerular filtration rate; and anesthetic recovery times were monitored. Oxygen delivery, vascular resistance, stroke volume, pulse pressure, and blood and plasma volume were calculated.
  
  
  RESULTS
  Increasing rates of LRS administration resulted in dose-dependent decreases in PCV; blood hemoglobin concentration and serum total protein and albumin concentrations; colloid osmotic pressure; and whole blood viscosity. Plasma viscosity; serum electrolyte concentrations; data from arterial and venous blood gas analysis; glomerular filtration rate; urine production; heart rate; pulse, central venous, and arterial blood pressures; pulmonary vascular resistance; and oxygen delivery did not change. Pulmonary artery pressure, stroke volume, and cardiac output increased, and systemic vascular resistance decreased.
  
  
  CONCLUSIONS
  Conventional IV infusion rates of LRS to isoflurane-anesthetized dogs decreased colligative blood components; increased plasma volume, pulmonary artery pressure, and cardiac output; and did not change urine production or oxygen delivery to tissues.
authors: QTest Laboratories, 6456 Fiesta Dr, Columbus, OH 43235, USA. bill.muir@amcny.org
authors: William W
authors: WW
authors: Muir
authors: Anusak
authors: A
authors: Kijtawornrat
authors: Yukie
authors: Y
authors: Ueyama
authors: Steven V
authors: SV
authors: Radecki
authors: Robert L
authors: RL
authors: Hamlin
mesh_terms: D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D001784:Blood Gas Analysis; D001794:Blood Pressure; D002302:Cardiac Output; D018592:Cross-Over Studies; D004285:Dogs / Q000097:blood* / Q000652:urine*; D005260:Female; D006863:Hydrogen-Ion Concentration; D007530:Isoflurane / Q000494:pharmacology*; D007552:Isotonic Solutions / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects; D007677:Kidney Function Tests / Q000662:veterinary; D008297:Male; D000077325:Ringer's Lactate; D014556:Urine / Q000737:chemistry
chemical_list: D018685:Anesthetics, Inhalation; D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D007530:Isoflurane