title: Cutaneous melanoma in patients in treatment with biological therapy: review of the literature and case report.
abstract: Herein we report a case of a melanoma arising in a patient receiving adalimumab and methotrexate for rheumatoid arthritis. A limited number of studies reported melanoma growth in patients undergoing treatment with biologics. This case report with a brief review of literature suggests that patients under treatment with biologics should be counseled to identify new pigmented lesions or changes in preexisting nevi. Clinicians' collaboration will facilitate recognition and timely diagnosis of early melanoma. If there is any doubt, excision for histological evaluation should be considered. Pending new studies, careful observation is encouraged.
authors: Ausilia Maria
authors: AM
authors: Manganoni
authors: Cristina
authors: C
authors: Zane
authors: Laura
authors: L
authors: Pavoni
authors: Camillo
authors: C
authors: Farisoglio
authors: Elena
authors: E
authors: Sereni
authors: Piergiacomo
authors: P
authors: Calzavara-Pinton
mesh_terms: D000068879:Adalimumab; D000368:Aged; D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001691:Biological Therapy / Q000009:adverse effects; D006801:Humans; D008297:Male; D008545:Melanoma / Q000139:chemically induced*; D008727:Methotrexate / Q000009:adverse effects*; D012878:Skin Neoplasms / Q000139:chemically induced*
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000068879:Adalimumab; D008727:Methotrexate