title: Sulfonamides as selective oestrogen receptor β agonists.
abstract: A series of p-hydroxybenzenesulphonamides ERβ receptor agonists were discovered and several compounds identified had excellent selectivity over the related ERα receptor. One of these, compound 11, had an interesting binding conformation determined by X-ray and represents an excellent starting point in the quest for further selective ERβ agonists.
authors: Worldwide Medicinal Chemistry, Pfizer, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK. lee.roberts@pfizer.com
authors: Lee R
authors: LR
authors: Roberts
authors: Duncan
authors: D
authors: Armor
authors: Carolyn
authors: C
authors: Barker
authors: Andrew
authors: A
authors: Bent
authors: Kirstin
authors: K
authors: Bess
authors: Alan
authors: A
authors: Brown
authors: David A
authors: DA
authors: Favor
authors: David
authors: D
authors: Ellis
authors: Stephen L
authors: SL
authors: Irving
authors: Malcolm
authors: M
authors: MacKenny
authors: Chris
authors: C
authors: Phillips
authors: Nick
authors: N
authors: Pullen
authors: Adam
authors: A
authors: Stennett
authors: Linda
authors: L
authors: Strand
authors: Michelle
authors: M
authors: Styles
mesh_terms: D055808:Drug Discovery; D047628:Estrogen Receptor alpha / Q000378:metabolism; D047629:Estrogen Receptor beta / Q000819:agonists* / Q000235:genetics / Q000378:metabolism; D005260:Female; D006801:Humans; D008024:Ligands; D008956:Models, Chemical; D011485:Protein Binding; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*
chemical_list: C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D008024:Ligands; D013449:Sulfonamides