title: Small antral follicle count (2-5 mm) and ovarian volume for prediction of pregnancy in in vitro fertilization cycles.
abstract: OBJECTIVE
  To assess the value of antral follicle count (AFC) and other parameters as predictors of pregnancy in in vitro fertilization (IVF).
  
  
  METHODS
  In a cohort study, unselected consecutive women in IVF treatment were evaluated. Pretreatment parameters included AFC (subpopulations of small (2-5 mm) and large (5-10 mm) AFC), ovarian volume, and ovarian stroma Doppler indices.
  
  
  RESULTS
  The study included 115 women of whom 38 (33%) were pregnant. Total AFC was significantly higher in the pregnant than in the non-pregnant group (13.7 ± 5.8 vs. 11.3 ± 5.3, p = 0.034). On receiver operator characteristic (ROC) curve analysis, the pretreatment variables that were significantly associated with pregnancy were small AFC (2-5 mm), total AFC, and ovarian volume/AFC ratio. Women with a positive score (total AFC >15; small AFC (2-5 mm) >10; ovarian volume in mm(3)/AFC, <1400), had a significantly higher number of retrieved oocytes and a higher pregnancy rate than women with a negative score (12.1 ± 5.1 vs. 8.7 ± 5.0, p = 0.027 and 58.3% vs. 30.1%, p = 0.049, respectively). On multivariate logistic regression analysis, total AFC was the only significant and independent predictor of pregnancy (p = 0.034).
  
  
  CONCLUSIONS
  Pretreatment small AFC and ovarian volume may identify women with a higher probability to achieve pregnancy in IVF.
authors: Department of Obstetrics and Gynecology, Infertility and IVF Unit, Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. yudavi@inter.net.il
authors: Avi
authors: A
authors: Ben-Haroush
authors: Jacob
authors: J
authors: Farhi
authors: Yasmin
authors: Y
authors: Zahalka
authors: Onit
authors: O
authors: Sapir
authors: Israel
authors: I
authors: Meizner
authors: Benjamin
authors: B
authors: Fisch
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007246:Infertility / Q000473:pathology / Q000628:therapy*; D007247:Infertility, Female / Q000473:pathology / Q000628:therapy; D007248:Infertility, Male / Q000628:therapy; D016015:Logistic Models; D008297:Male; D054315:Oocyte Retrieval; D009929:Organ Size; D006080:Ovarian Follicle / Q000033:anatomy & histology / Q000000981:diagnostic imaging* / Q000473:pathology; D010053:Ovary / Q000033:anatomy & histology / Q000000981:diagnostic imaging* / Q000473:pathology; D011247:Pregnancy; D018873:Pregnancy Rate; D012372:ROC Curve; D014463:Ultrasonography