title: Role of cardiovascular magnetic resonance as a gatekeeper to invasive coronary angiography in patients presenting with heart failure of unknown etiology.
abstract: BACKGROUND
  In patients presenting with new-onset heart failure of uncertain etiology, the role of coronary angiography (CA) is unclear. Although conventionally performed to differentiate underlying coronary artery disease from dilated cardiomyopathy, CA is associated with a risk of complications and may not detect an ischemic cause resulting from arterial recanalization or an embolic episode. In this study, we assessed the diagnostic accuracy of a cardiovascular magnetic resonance (CMR) protocol incorporating late gadolinium enhancement (LGE) and magnetic resonance CA as a noninvasive gatekeeper to CA in determining the etiology of heart failure in this subset of patients.
  
  
  RESULTS
  One hundred twenty consecutive patients underwent CMR and CA. The etiology was ascribed by a consensus panel that used the results of the CMR scans. Similarly, a separate consensus group ascribed an underlying cause by using the results of CA. The diagnostic accuracy of both strategies was compared against a gold-standard panel that made a definitive judgment by reviewing all clinical data. The study was powered to show noninferiority between the 2 techniques. The sensitivity of 100%, specificity of 96%, and diagnostic accuracy of 97% for LGE-CMR were equivalent to CA (sensitivity, 93%; specificity, 96%; and diagnostic accuracy, 95%). As a gatekeeper to CA, LGE-CMR was also found to be a cheaper diagnostic strategy in a decision tree model when United Kingdom-based costs were assumed. The economic merits of this model would change, depending on the relative costs of LGE-CMR and CA in any specific healthcare system.
  
  
  CONCLUSIONS
  This study showed that LGE-CMR is a safe, clinically effective, and potentially economical gatekeeper to CA in patients presenting with heart failure of uncertain etiology.
authors: Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, London, UK.
authors: Ravi G
authors: RG
authors: Assomull
authors: Carl
authors: C
authors: Shakespeare
authors: Paul R
authors: PR
authors: Kalra
authors: Guy
authors: G
authors: Lloyd
authors: Ankur
authors: A
authors: Gulati
authors: Julian
authors: J
authors: Strange
authors: William M
authors: WM
authors: Bradlow
authors: Jonathan
authors: J
authors: Lyne
authors: Jennifer
authors: J
authors: Keegan
authors: Philip
authors: P
authors: Poole-Wilson
authors: Martin R
authors: MR
authors: Cowie
authors: Dudley J
authors: DJ
authors: Pennell
authors: Sanjay K
authors: SK
authors: Prasad
mesh_terms: D000368:Aged; D057791:Cardiac Imaging Techniques / Q000191:economics / Q000592:standards* / Q000706:statistics & numerical data; D017023:Coronary Angiography / Q000191:economics; D003663:Decision Trees; D005260:Female; D005500:Follow-Up Studies; D005682:Gadolinium; D017048:Health Care Costs; D006333:Heart Failure / Q000175:diagnosis* / Q000191:economics / Q000209:etiology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000191:economics / Q000592:standards* / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D012017:Referral and Consultation / Q000191:economics / Q000592:standards / Q000706:statistics & numerical data; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D006113:United Kingdom
chemical_list: D005682:Gadolinium