title: Cutaneous metastasis as the initial manifestation of lung adenocarcinoma.
abstract: We report the case of a 58-year-old male patient who was referred for oncology consultation due to an epigastric mass that had been growing rapidly for three months. Diagnostic investigation revealed that the mass was a metastasis of stage IV lung adenocarcinoma. The patient received five cycles of chemotherapy with cisplatin and gemcitabine as a first-line treatment, which was interrupted due to major adverse events. Although the pulmonary disease stabilized, the cutaneous disease progressed. The patient then received pemetrexed as a second-line chemotherapy, together with concurrent external radiotherapy, which was well tolerated. There was complete remission of the epigastric mass. However, the patient died three months after the treatment. Here, we emphasize the importance of a multidisciplinary approach and of its role in individualizing the treatment.
authors: Francisco Gentil Portuguese Oncology Institute, Porto, Portugal. mpantarotto@med.up.pt
authors: Marcos
authors: M
authors: Pantarotto
authors: Liliana
authors: L
authors: Lombo
authors: Helena
authors: H
authors: Pereira
authors: Antonio
authors: A
authors: Araújo
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000556:secondary*; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001706:Biopsy; D017809:Fatal Outcome; D005971:Glutamates / Q000627:therapeutic use; D006147:Guanine / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D000068437:Pemetrexed; D012878:Skin Neoplasms / Q000188:drug therapy / Q000556:secondary*
chemical_list: D000970:Antineoplastic Agents; D005971:Glutamates; D000068437:Pemetrexed; D006147:Guanine