title: Toward the blood-borne miRNome of human diseases.
abstract: In a multicenter study, we determined the expression profiles of 863 microRNAs by array analysis of 454 blood samples from human individuals with different cancers or noncancer diseases, and validated this 'miRNome' by quantitative real-time PCR. We detected consistently deregulated profiles for all tested diseases; pathway analysis confirmed disease association of the respective microRNAs. We observed significant correlations (P = 0.004) between the genomic location of disease-associated genetic variants and deregulated microRNAs.
authors: Biomarker Discovery Center, Heidelberg, Germany. ack@bioinf.uni-sb.de
authors: Andreas
authors: A
authors: Keller
authors: Petra
authors: P
authors: Leidinger
authors: Andrea
authors: A
authors: Bauer
authors: Abdou
authors: A
authors: Elsharawy
authors: Jan
authors: J
authors: Haas
authors: Christina
authors: C
authors: Backes
authors: Anke
authors: A
authors: Wendschlag
authors: Nathalia
authors: N
authors: Giese
authors: Christine
authors: C
authors: Tjaden
authors: Katja
authors: K
authors: Ott
authors: Jens
authors: J
authors: Werner
authors: Thilo
authors: T
authors: Hackert
authors: Klemens
authors: K
authors: Ruprecht
authors: Hanno
authors: H
authors: Huwer
authors: Junko
authors: J
authors: Huebers
authors: Gunnar
authors: G
authors: Jacobs
authors: Philip
authors: P
authors: Rosenstiel
authors: Henrik
authors: H
authors: Dommisch
authors: Arne
authors: A
authors: Schaefer
authors: Joachim
authors: J
authors: Müller-Quernheim
authors: Bernd
authors: B
authors: Wullich
authors: Bastian
authors: B
authors: Keck
authors: Norbert
authors: N
authors: Graf
authors: Joerg
authors: J
authors: Reichrath
authors: Britta
authors: B
authors: Vogel
authors: Almut
authors: A
authors: Nebel
authors: Sven U
authors: SU
authors: Jager
authors: Peer
authors: P
authors: Staehler
authors: Ioannis
authors: I
authors: Amarantos
authors: Valesca
authors: V
authors: Boisguerin
authors: Cord
authors: C
authors: Staehler
authors: Markus
authors: M
authors: Beier
authors: Matthias
authors: M
authors: Scheffler
authors: Markus W
authors: MW
authors: Büchler
authors: Joerg
authors: J
authors: Wischhusen
authors: Sebastian F M
authors: SF
authors: Haeusler
authors: Johannes
authors: J
authors: Dietl
authors: Sylvia
authors: S
authors: Hofmann
authors: Hans-Peter
authors: HP
authors: Lenhof
authors: Stefan
authors: S
authors: Schreiber
authors: Hugo A
authors: HA
authors: Katus
authors: Wolfgang
authors: W
authors: Rottbauer
authors: Benjamin
authors: B
authors: Meder
authors: Joerg D
authors: JD
authors: Hoheisel
authors: Andre
authors: A
authors: Franke
authors: Eckart
authors: E
authors: Meese
mesh_terms: D004194:Disease / Q000235:genetics*; D020869:Gene Expression Profiling; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D035683:MicroRNAs