title: Digoxin toxicity precipitated by clarithromycin use: case presentation and concise review of the literature.
abstract: We present a case of digoxin toxicity in the context of dehydration, renal dysfunction and concomitant use of the macrolide antibiotic, clarithromycin, which is known to inhibit P-glycoprotein-mediated efflux mechanisms of digoxin. A focused review of the literature is presented. Health care providers need to be vigilant of this mechanism of drug-drug interaction, which is also relevant to other commonly used cardiovascular drugs.
authors: Montreal Heart Institute, Université de Montréal, Montreal, Québec, Canada.
authors: Candace Y W
authors: CY
authors: Lee
authors: François
authors: F
authors: Marcotte
authors: Geneviève
authors: G
authors: Giraldeau
authors: Gideon
authors: G
authors: Koren
authors: Martin
authors: M
authors: Juneau
authors: Jean-Claude
authors: JC
authors: Tardif
mesh_terms: D000369:Aged, 80 and over; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D017291:Clarithromycin / Q000627:therapeutic use*; D004077:Digoxin / Q000009:adverse effects* / Q000627:therapeutic use; D004347:Drug Interactions; D005500:Follow-Up Studies; D006333:Heart Failure / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D011014:Pneumonia / Q000150:complications / Q000188:drug therapy*
chemical_list: D000889:Anti-Arrhythmia Agents; D000900:Anti-Bacterial Agents; D004077:Digoxin; D017291:Clarithromycin