title: One new pregnane glycoside from the seeds of cultivated Brucea javanica.
abstract: A new pregnane glycoside, named (20R)-O-(3)-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosyl-pregn-5-en-3β,20-diol (1), and seven known compounds, brusatol (2), bruceine B (3), bruceine D (4), yadanziolide A (5), bruceine E (6), yadanzioside G (7), and yadanzioside B (8), were isolated from the cultivated dry seeds of Brucea javanica. The structure of 1 was elucidated on the basis of 1D- and 2D-NMR spectroscopic analyses. Their inhibitory effects on tumor cells were also tested. Compound 1 was slightly active against HL-60, SMMC-7721, A-549, and MCF-7 tumor cells. Compounds 2 and 3 demonstrated significant inhibitory activities against all tested cells. These results indicate that cultivated B. javanica could replace the wild plant as an antitumor plant resource.
authors: State Key Laboratory of Photochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, China.
authors: Jie-Qing
authors: JQ
authors: Liu
authors: Cui-Fang
authors: CF
authors: Wang
authors: Xing-Yao
authors: XY
authors: Li
authors: Jian-Chao
authors: JC
authors: Chen
authors: Yan
authors: Y
authors: Li
authors: Ming-Hua
authors: MH
authors: Qiu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D032269:Brucea / Q000737:chemistry*; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D004354:Drug Screening Assays, Antitumor; D005638:Fruit; D006801:Humans; D015394:Molecular Structure; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal; D036702:Quassins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D012639:Seeds
chemical_list: D000970:Antineoplastic Agents; C570593:O-(3)-glucopyranosyl-(1-2)-arabinopyranosylpregn-5-en-3,20-diol; D010936:Plant Extracts; D036702:Quassins; D012503:Saponins; C020237:brusatol