title: Cytotoxic C21 and C22 terpenoid-derived metabolites from the sponge Ircinia sp.
abstract: One novel C21 terpenoidal natural product, ircinolin A (2), two new C22 furanoterpene metabolites, 15-acetylirciformonin B (3) and 10-acetylirciformonin B (4), and two known compounds, irciformonin B (1) and irciformonin F (5), were isolated from the sponge Ircinia sp. The structures of these compounds were elucidated on the basis of their spectroscopic data. Moreover, the absolute configuration of 1 was determined by Mosher's method. Among these metabolites, 2 is the first C21 terpenoid-derived metabolite to be reported from this genus. Compounds 1 and 3-5 exhibited significant cytotoxic activity against K562, DLD-1, HepG2, and Hep3B cancer cell lines.
authors: Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan, Republic of China. x2219@nmmba.gov.tw
authors: Jui-Hsin
authors: JH
authors: Su
authors: Shang-Wei
authors: SW
authors: Tseng
authors: Mei-Chin
authors: MC
authors: Lu
authors: Li-Lian
authors: LL
authors: Liu
authors: Yalan
authors: Y
authors: Chou
authors: Ping-Jyun
authors: PJ
authors: Sung
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D056945:Hep G2 Cells; D006801:Humans; D020014:K562 Cells; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: C562206:10-acetylirciformonin B; C562205:15-acetylirciformonin B; D000970:Antineoplastic Agents; D013729:Terpenes; C562204:ircinolin A