title: Effect of Cuscuta chinensis on renal function in ischemia/reperfusion-induced acute renal failure rats.
abstract: The kidneys play a central role in regulating water, ion composition and excretion of metabolic waste products in the urine. Cuscuta chinensis has been known as an important traditional Oriental medicine for the treatment of liver and kidney disorders. Thus, we studied whether an aqueous extract of Cuscuta chinensis (ACC) seeds has an effect on renal function parameters in ischemia/reperfusion-induced acute renal failure (ARF) rats. Administration of 250 mg/kg/day ACC showed that renal functional parameters including urinary excretion rate, osmolality, Na(+), K(+), Cl(-), creatinine clearance, solute-free water reabsorption were significantly recovered in ischemia/reperfusion-induced ARF. Periodic acid Schiff staining showed that administration of ACC improved tubular damage in ischemia/reperfusion-induced ARF. In immunoblot and immunohistological examinations, ischemia/reperfusion-induced ARF decreased the expressions of water channel AQP 2, 3 and sodium potassium pump Na,K-ATPase in the renal medulla. However, administration of ACC markedly incremented AQP 2, 3 and Na,K-ATPase expressions. Therefore, these data indicate that administration of ACC ameliorates regulation of the urine concentration and renal functions in rats with ischemia/reperfusion-induced ARF.
authors: Professional Graduate School of Oriental Medicine and College of Oriental Medicine, Republic of Korea.
authors: Sun
authors: S
authors: Shin
authors: Yun Jung
authors: YJ
authors: Lee
authors: Eun Ju
authors: EJ
authors: Kim
authors: An Sook
authors: AS
authors: Lee
authors: Dae Gill
authors: DG
authors: Kang
authors: Ho Sub
authors: HS
authors: Lee
mesh_terms: D058186:Acute Kidney Injury / Q000188:drug therapy* / Q000503:physiopathology; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D034182:Cuscuta / Q000737:chemistry*; D004195:Disease Models, Animal; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000150:complications*
chemical_list: D000975:Antioxidants; D010936:Plant Extracts