title: [Change in body compositions in female patients with human immunodeficiency virus related lipodystrophy syndrome].
abstract: OBJECTIVE
  To study the changes of body composition in females patients with human immunodeficiency virus (HIV)-related lipodystrophy (LD) syndrome (HIV-LD).
  
  
  METHODS
  Totally 25 female patients who were treated in our hospital from January 2002 to December 2009 were divided into LD group and non-LD group based on the existence of LD. All these patients were receiving highly active antiretroviral therapy (HAART). In addition, 12 healthy women were set as the controls. Total and regional body composition were measured by dual X-ray absorptiometry in all three groups.
  
  
  RESULTS
  The fat mass (FM) was correlated negatively with the duration of HAART (r=-0.431, P=0.029). Multiple linear regression analysis showed that FM had positive correlation with weight and negative correlation with lean mass (LM) (r = - 0. 973, P =0. 000). Total, trunk and leg FM were significantly lower in LD patients than that in controls (P <0.05).Meanwhile, total, trunk and leg bone mineral contents were statistically lower in LD patients than that in controls (P <0. 05). Lumbar bone mineral density of LD patients was lower than that of non-LD patients and controls, and there was significant difference between LD patients and controls (P = 0. 001). LM of LD patients was higher than that of non-LD patients but without statistical difference (P > 0. 05).
  
  
  CONCLUSIONS
  The peripheral and central FM and bone mineral contents remarkably decrease in female patients with HIV-LD. How-ever, HIV-LD patients tend to have higher LM than non-LD patients. .
authors: Department of Radiology, PUMC Hospital, CAMS and PUMC, Beijing, China.
authors: Jing-peng
authors: JP
authors: Yao
authors: Wei
authors: W
authors: Yu
authors: Tai-sheng
authors: TS
authors: Li
authors: Ling
authors: L
authors: Luo
authors: Qiang
authors: Q
authors: Lin
authors: Jun-ping
authors: JP
authors: Tian
authors: Yin-juan
authors: YJ
authors: Chang
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D001823:Body Composition / Q000502:physiology*; D015519:Bone Density / Q000502:physiology; D005260:Female; D039682:HIV-Associated Lipodystrophy Syndrome / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D055815:Young Adult