title: High bone marrow angiopoietin-1 expression is an independent poor prognostic factor for survival in patients with myelodysplastic syndromes.
abstract: BACKGROUND
  Angiogenic factors have an essential role in normal and pathologic angiogenesis. However, the clinical implication of angiogenic factor expression in myelodysplastic syndromes (MDS) remains unclear.
  
  
  METHODS
  In this study, we sought to investigate the prognostic impact of the expression of genes encoding angiopoietin-1 (Ang-1), Ang-2, the receptor Tie2, vascular endothelial growth factor-A (VEGF-A) and VEGF-C in the bone marrow (BM) in 208 patients with newly diagnosed primary MDS.
  
  
  RESULTS
  BM Ang-1 expression was significantly higher in MDS patients, especially those with higher-risk subtypes, than in normal controls. With a median follow-up time of 32.9 months, the disease transformed to acute leukaemia more frequently in the patients bearing higher Ang-1 expression than in those with lower expression (31.5% vs 18.6%, P=0.023). The MDS patients with higher Ang-1 expression had shorter overall survival than those with lower expression (median 20.8±4.5 months vs 63.3±17.8 months, P<0.001). Multivariate analyses showed that higher Ang-1 expression was an independent unfavourable prognostic factor for overall survival. There was no impact of the expression of other angiogenic factors on survival.
  
  
  CONCLUSIONS
  BM Ang-1 expression may serve as a new biomarker to predict clinical outcome in MDS patients.
authors: Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, No. 7, Chung-Shan South Road, Taipei 10002, Taiwan.
authors: C-L
authors: CL
authors: Cheng
authors: H-A
authors: HA
authors: Hou
authors: J-Y
authors: JY
authors: Jhuang
authors: C-W
authors: CW
authors: Lin
authors: C-Y
authors: CY
authors: Chen
authors: J-L
authors: JL
authors: Tang
authors: W-C
authors: WC
authors: Chou
authors: M-H
authors: MH
authors: Tseng
authors: M
authors: M
authors: Yao
authors: S-Y
authors: SY
authors: Huang
authors: B-S
authors: BS
authors: Ko
authors: S-C
authors: SC
authors: Hsu
authors: S-J
authors: SJ
authors: Wu
authors: W
authors: W
authors: Tsay
authors: Y-C
authors: YC
authors: Chen
authors: H-F
authors: HF
authors: Tien
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D042683:Angiopoietin-1 / Q000235:genetics / Q000378:metabolism*; D042702:Angiopoietin-2 / Q000235:genetics / Q000378:metabolism; D001853:Bone Marrow / Q000378:metabolism*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics / Q000378:metabolism* / Q000401:mortality*; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics; D042787:Receptor, TIE-2 / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015996:Survival Rate; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism; D042582:Vascular Endothelial Growth Factor C / Q000235:genetics / Q000378:metabolism; D055815:Young Adult
chemical_list: D042683:Angiopoietin-1; D042702:Angiopoietin-2; D012333:RNA, Messenger; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D042582:Vascular Endothelial Growth Factor C; D042787:Receptor, TIE-2