title: The effect of palm wine on lipid peroxidation and antioxidant status of rural dwellers in South West Nigeria.
abstract: OBJECTIVE
  To evaluate the levels/activities of antioxidants and lipid peroxidation in the blood of subjects that consumed palm wine on regular bases.
  
  
  METHODS
  Sixty-four male volunteers between the ages of 30-70 years were recruited for the study. The subjects were those that visited palm wine vendor outlet on regular basis at least for a minimum duration of 5 years, with daily intake of 80-160 gm of palm wine at a sitting for a minimum of 3 to 4 days per week. Plasma activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyltransferase (a-GT); plasma concentration of total antioxidant status (TAS), Malonyldialdehyde ((MDA), selenium (Se) and erythrocyte glutathione peroxidase (GSH-Px) activity were determined.
  
  
  RESULTS
  The plasma activity of a-GT and marker of lipid peroxidation (MDA) were significantly increased in subjects compared to the controls p<0.01. However, the erythrocyte scavenging antioxidant activity of GSH-Px and plasma Se for the subjects were significantly reduced compared to the controls p<0.05. Positive correlation was observed between MDA/ level of palm wine consumption (r =+ 0.471, p<0.01), AST/ level of palm wine consumption (r=+ 0.263, p<0.05) and a- GT/level of palm wine consumption (r=+ 0.518, p< 0.001) for the subjects. However, a negative correlation was obtained between GSH-Px/level of palm wine consumption (r= - 0.364, p<0.05) and selenium/ level of palm wine consumption (r=- 0.375, p< 0.05) for the subjects.
  
  
  CONCLUSIONS
  Reduced plasma Se and erythrocytes GSH-Px activity with increased plasma MDA in this study revealed that palm wine consumption may deplete the body's antioxidants against free radical attacks and render the body in a state of oxidative stress.
authors: Department of Chemical Pathology College of Health Science, Ladoke Akintola University of Technology, Osogbo, Nigeria. ogunrops@yahoo.com
authors: P S
authors: PS
authors: Ogunro
authors: P O
authors: PO
authors: Ologunagba
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000378:metabolism; D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology; D001219:Aspartate Aminotransferases / Q000378:metabolism; D015415:Biomarkers; D016022:Case-Control Studies; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D009549:Nigeria; D018384:Oxidative Stress; D012424:Rural Population; D012643:Selenium / Q000097:blood; D014920:Wine; D055815:Young Adult; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D012643:Selenium