title: Facing the gem-dialkyl effect in enzyme inhibitor design: preparation of homocycloleucine-based azadipeptide nitriles.
authors: Pharmaceutical Chemistry I, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany.
authors: Maxim
authors: M
authors: Frizler
authors: Friederike
authors: F
authors: Lohr
authors: Michael
authors: M
authors: Lülsdorff
authors: Michael
authors: M
authors: Gütschow
mesh_terms: D056657:Cathepsin K / Q000138:chemical synthesis* / Q000737:chemistry; D004151:Dipeptides / Q000138:chemical synthesis* / Q000737:chemistry; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006860:Hydrogen Bonding; D007930:Leucine / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D004151:Dipeptides; D004791:Enzyme Inhibitors; D009570:Nitriles; D056657:Cathepsin K; D007930:Leucine