title: Rorγt+ innate lymphoid cells in intestinal homeostasis and immunity.
abstract: Innate lymphoid cells (ILC) combine innate and adaptive immune functions and are part of the first line of defense against mucosal infections. ILC are set apart from adaptive lymphocytes by their independence on RAG genes and the resulting absence of specific antigen receptors. In this review, we will discuss the biology and function of intestinal ILC that express the nuclear hormone receptor Rorγt (encoded by the Rorc gene) and highlight their role in intestinal homeostasis and immunity.
authors: Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors: Patricia
authors: P
authors: Aparicio-Domingo
authors: Tom
authors: T
authors: Cupedo
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D002450:Cell Communication; D016207:Cytokines / Q000276:immunology; D006706:Homeostasis; D006801:Humans; D007113:Immunity, Innate; D007413:Intestinal Mucosa / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000276:immunology*; D015398:Signal Transduction
chemical_list: D016207:Cytokines; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3