title: Correlation between serum linezolid concentration and the development of thrombocytopenia.
abstract: We evaluated the possible association between trough linezolid (LZD) concentrations and platelet counts using a dose-response curve with a logit model equation. We demonstrated that trough LZD concentrations correlated with platelet counts. A significant decrease in platelet count was observed in patients with trough LZD concentrations higher than 22.1 μg/ml.
authors: Department of Pharmacy, National Hospital Organization Kumamoto Medical Center, Kumamoto, Kumamoto, Japan. hiraki@kumamoto2.hosp.go.jp
authors: Yoichi
authors: Y
authors: Hiraki
authors: Yasuhiro
authors: Y
authors: Tsuji
authors: Mikako
authors: M
authors: Hiraike
authors: Nobuhiro
authors: N
authors: Misumi
authors: Kana
authors: K
authors: Matsumoto
authors: Kunihiko
authors: K
authors: Morita
authors: Hidetoshi
authors: H
authors: Kamimura
authors: Yoshiharu
authors: Y
authors: Karube
mesh_terms: D000081:Acetamides / Q000097:blood / Q000493:pharmacokinetics*; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000097:blood / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D000069349:Linezolid; D008297:Male; D008875:Middle Aged; D023303:Oxazolidinones / Q000097:blood / Q000493:pharmacokinetics*; D010976:Platelet Count; D011014:Pneumonia / Q000188:drug therapy; D011446:Prospective Studies; D013921:Thrombocytopenia / Q000453:epidemiology*
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid