title: [Interest of FDG-PET for lung cancer radiotherapy].
abstract: The recent advances in medical imaging have profoundly altered the radiotherapy of non-small cell lung cancers (NSCLC). A meta-analysis has confirmed the superiority of FDG PET-CT over CT for initial staging. FDG PET-CT improves the reproducibility of target volume delineation, especially close to the mediastinum or in the presence of atelectasia. Although not formally validated by a randomized trial, the reduction of the mediastinal target volume, by restricting the irradiation to FDG-avid nodes, is widely accepted. The optimal method of delineation still remains to be defined. The role of FDG PET-CT in monitoring tumor response during radiotherapy is under investigation, potentially opening the way to adapting the treatment modalities to tumor radiation sensitivity. Other tracers, such as F-miso (hypoxia), are also under clinical investigation. To avoid excessive delays, the integration of PET-CT in routine practice requires quick access to the imaging equipment, technical support (fusion and image processing) and multidisciplinary delineation of target volumes.
authors: Département de radiothérapie et de physique médicale et QuantIF - Litis (EA 4108), CRLCC Henri-Becquerel, 1, rue d'Amiens, 76038 Rouen, France.
authors: S
authors: S
authors: Thureau
authors: S
authors: S
authors: Mezzani-Saillard
authors: R
authors: R
authors: Modzelewski
authors: A
authors: A
authors: Edet-Sanson
authors: B
authors: B
authors: Dubray
authors: P
authors: P
authors: Vera
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000556:secondary; D002986:Clinical Trials as Topic; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging; D008482:Mediastinum / Q000000981:diagnostic imaging; D009367:Neoplasm Staging / Q000379:methods; D049268:Positron-Emission Tomography; D011379:Prognosis; D013997:Time Factors; D016896:Treatment Outcome; D047368:Tumor Burden
chemical_list: D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18