title: Wnt: what's needed to maintain pluripotency?
abstract: A precise role for the canonical Wnt pathway in maintaining pluripotency in mouse embryonic stem cells (mESCs) has been debated. Four recent reports add pieces to the puzzle and together these results may help establish a robust model.
authors: Hitoshi
authors: H
authors: Niwa
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism*; D002454:Cell Differentiation / Q000187:drug effects* / Q000502:physiology*; D002465:Cell Movement; D049109:Cell Proliferation; D053595:Embryonic Stem Cells / Q000187:drug effects* / Q000378:metabolism*; D005260:Female; D005855:Germ Layers / Q000378:metabolism*; D038362:Glycogen Synthase Kinase 3 / Q000037:antagonists & inhibitors*; D051538:Hepatocyte Nuclear Factor 1-alpha / Q000378:metabolism*; D039904:Pluripotent Stem Cells / Q000187:drug effects*; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D015398:Signal Transduction; D013234:Stem Cells / Q000378:metabolism*; D051153:Wnt Proteins / Q000378:metabolism*; D060509:Wnt3A Protein / Q000378:metabolism*; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D038362:Glycogen Synthase Kinase 3; D051538:Hepatocyte Nuclear Factor 1-alpha; D047428:Protein Kinase Inhibitors; D051153:Wnt Proteins; D060509:Wnt3A Protein; D051176:beta Catenin; C555511:Wnt3a protein, mouse