title: Genomic analysis of non-splenic marginal zone lymphomas (MZL) indicates similarities between nodal and extranodal MZL and supports their derivation from memory B-cells.
abstract: Three distinct categories of marginal zone lymphomas (MZLs) are currently recognized, principally based on their site of occurrence. They are thought to represent unique entities, but the relationship of one subtype with another is poorly understood. We investigated 17 non-splenic MZLs (seven nodal, 10 extranodal) by gene expression profiling to distinguish between subtypes and determine their cell of origin. Our findings suggest biological inter-relatedness of these entities despite occurrence at different locations and associations with possibly different aetiologies. Furthermore, the expression profiles of non-splenic MZL were similar to memory B cells.
authors: Departments of Pathology and Cell Biology             Genetics and Development             Herbert Irving Comprehensive Cancer Center             Institute for Cancer Genetics, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USA.
authors: Urban
authors: U
authors: Novak
authors: Katia
authors: K
authors: Basso
authors: Laura
authors: L
authors: Pasqualucci
authors: Riccardo
authors: R
authors: Dalla-Favera
authors: Govind
authors: G
authors: Bhagat
mesh_terms: D016175:B-Lymphocyte Subsets / Q000276:immunology / Q000473:pathology; D020869:Gene Expression Profiling; D023281:Genomics / Q000379:methods; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics* / Q000276:immunology / Q000473:pathology