title: Site-selective DNA hydrolysis induced by a metal-free peptide nucleic acid-cyclen conjugate.
abstract: A metal-free artificial restriction DNA cutter which is composed of cyclen and classical peptide nucleic acid (PNA) was synthesized. Analysis of DNA cleavage products indicates the site-selective hydrolysis.
authors: Key Laboratory of Green Chemistry and Technology (Ministry of Education), College of Chemistry, Sichuan University, Chengdu, 610064, PR China.
authors: Ming-Qi
authors: MQ
authors: Wang
authors: Jun-Liang
authors: JL
authors: Liu
authors: Jing-Yi
authors: JY
authors: Wang
authors: Da-Wei
authors: DW
authors: Zhang
authors: Ji
authors: J
authors: Zhang
authors: Frank
authors: F
authors: Streckenbach
authors: Zhuo
authors: Z
authors: Tang
authors: Hong-Hui
authors: HH
authors: Lin
authors: Yan
authors: Y
authors: Liu
authors: Yu-Fen
authors: YF
authors: Zhao
authors: Xiao-Qi
authors: XQ
authors: Yu
mesh_terms: D001665:Binding Sites; D000080027:Cyclams; D004247:DNA / Q000737:chemistry*; D053837:DNA Cleavage; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006868:Hydrolysis; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D013379:Substrate Specificity
chemical_list: D000080027:Cyclams; D006571:Heterocyclic Compounds; D020135:Peptide Nucleic Acids; D004247:DNA; C038072:cyclen