title: Design and synthesis of inhibitors of noroviruses by scaffold hopping.
abstract: A scaffold hopping strategy was employed to identify new chemotypes that inhibit noroviruses. The replacement of the cyclosulfamide scaffold by an array of heterocyclic scaffolds lead to the identification of additional series of compounds that possessed anti-norovirus activity in a cell-based replicon system.
authors: Department of Chemistry, Wichita State University, Wichita, KS 67260, United States.
authors: Dengfeng
authors: D
authors: Dou
authors: Sivakoteswara Rao
authors: SR
authors: Mandadapu
authors: Kevin R
authors: KR
authors: Alliston
authors: Yunjeong
authors: Y
authors: Kim
authors: Kyeong-Ok
authors: KO
authors: Chang
authors: William C
authors: WC
authors: Groutas
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D006571:Heterocyclic Compounds / Q000737:chemistry; D006801:Humans; D029322:Norovirus / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000577:Amides; D000998:Antiviral Agents; D006571:Heterocyclic Compounds