title: Synthesis and antimicrobial activity of amido linked pyrrolyl and pyrazolyl-oxazoles, thiazoles and imidazoles.
abstract: A new class of amido linked bis heterocycles viz., pyrrolyl/pyrazolyl-oxazoles, thiazoles and imidazoles were prepared by 1,3-dipolar cycloaddition of TosMIC and diazomethane to the respective cinnamamide derivatives and screened for antimicrobial activity. The chlorosubstituted imidazolyl cinnamamide (6c) is the most potential antimicrobial agent as it displayed strong antibacterial activity against Bacillus subtilis and antifungal activity against Penicillium chrysogenum.
authors: Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India. vkpuram2001@yahoo.com
authors: V
authors: V
authors: Padmavathi
authors: C
authors: C
authors: Prema Kumari
authors: B C
authors: BC
authors: Venkatesh
authors: A
authors: A
authors: Padmaja
mesh_terms: D000577:Amides / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001393:Azoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000577:Amides; D000890:Anti-Infective Agents; D001393:Azoles; D011758:Pyrroles