title: Association of atherosclerotic cerebral infarction and human leukocyte antigen-DRB in a North Chinese Han population.
abstract: OBJECTIVE
  Evidence from experimental and genetic studies suggest the existence of a potential link between the polymorphisms of human leukocyte antigen class II gene (HLA-DR) and ischemic stroke. This study addressed the association of HLA-DR gene with atherosclerotic cerebral infarction (ACI) in a North Chinese Han population.
  
  
  METHODS
  The genotyping of HLA-DRB1 was determined by standard techniques based on polymerase chain reaction and sequence-specific oligonucleotides hybridization in a gene chip.
  
  
  RESULTS
  The relative risk (RR) of HLA-DRB1 FNx01 04 and HLA-DRB1 FNx01 03 (17) in patients with ACI and their first-degree relatives were significantly higher than those in the control group (RR=2.56 and 18.77, respectively; P <0.05). In contrast, the RR of HLA-DRB1 FNx01 12 was dramatically reduced in patients with ACI in relation to healthy controls (RR=0.17; P <0.01).
  
  
  CONCLUSIONS
  These data indicate that the polymorphisms in HLA-DRB1 may influence the risk of ACI in the North Han population of China. Further studies are necessary to validate the observation in larger samples.
authors: Department of Neurology, China-Japan Union Hospital, Jilin University, Changchun, Jilin, China.
authors: Song-Yan
authors: SY
authors: Liu
authors: Ying
authors: Y
authors: Chang
authors: Shuang-Yan
authors: SY
authors: Zhang
authors: Wei
authors: W
authors: Wu
authors: Bo-Jian
authors: BJ
authors: Sun
authors: Xue-Mei
authors: XM
authors: Han
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D020520:Brain Infarction / Q000150:complications / Q000235:genetics*; D002681:China / Q000208:ethnology; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000150:complications / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains