title: The fentanyl/etomidate-anesthetized beagle (FEAB) model in safety pharmacology assessment.
abstract: This unit describes a procedure for performing safety studies in the anesthetized beagle dog. Detailed are the anesthetic regime, the surgical procedure, and all materials needed to perform cardiovascular, central nervous system, and respiratory safety studies in these animals. An overview of all parameters that can be measured and calculated is provided, as are experimental protocols. Endpoints discussed include hemodynamic, electrocardiological, respiratory, arterial blood, and electroencephalogical parameters. Also presented are a formula to correct QT interval for changes in core body temperature and an overview of changes in ECG, MAP, and EEG traces that may occur during safety studies. The information provided yields a multiparametric model for performing reliable safety studies in anesthetized dogs.
authors: Janssen Pharmaceutical Research & Development, A Division of Janssen Pharmaceutica NV, Beerse, Belgium.
authors: Henk J
authors: HJ
authors: van der Linde
authors: Bruno Van
authors: BV
authors: Deuren
authors: Yves
authors: Y
authors: Somers
authors: Ard
authors: A
authors: Teisman
authors: David J
authors: DJ
authors: Gallacher
mesh_terms: D018686:Anesthetics, Intravenous; D000818:Animals; D004285:Dogs; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D005045:Etomidate / Q000494:pharmacology*; D005283:Fentanyl / Q000494:pharmacology*; D018675:Toxicity Tests / Q000379:methods*
chemical_list: D018686:Anesthetics, Intravenous; D005283:Fentanyl; D005045:Etomidate