title: The role of heat shock factors in stress-induced transcription.
abstract: Heat shock proteins (HSPs) are rapidly induced after stresses, such as heat shock, and accumulate at high concentrations in cells. HSP induction involves a family of heat shock transcription factors that bind the heat shock elements of the HSP genes and mediate transcription in trans. We discuss methods for the study of HSP binding to HSP promoters and the consequent increases in HSP gene expression in vitro and in vivo.
authors: Molecular and Cellular Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
authors: Yue
authors: Y
authors: Zhang
authors: Shiuh-Dih
authors: SD
authors: Chou
authors: Ayesha
authors: A
authors: Murshid
authors: Thomas L
authors: TL
authors: Prince
authors: Sheila
authors: S
authors: Schreiner
authors: Mary Ann
authors: MA
authors: Stevenson
authors: Stuart K
authors: SK
authors: Calderwood
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D017931:DNA Primers; D005786:Gene Expression Regulation; D006367:HeLa Cells; D006360:Heat-Shock Proteins / Q000235:genetics* / Q000378:metabolism*; D018869:Heat-Shock Response / Q000235:genetics*; D006801:Humans; D051379:Mice; D041681:NIH 3T3 Cells; D013312:Stress, Physiological; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D017931:DNA Primers; D006360:Heat-Shock Proteins; D014157:Transcription Factors