title: Natural products: an evolving role in future drug discovery.
abstract: The therapeutic areas of infectious diseases and oncology have benefited from abundant scaffold diversity in natural products, able to interact with many specific targets within the cell and indeed for many years have been source or inspiration for the majority of FDA approved drugs. The present review describes natural products (NPs), semi-synthetic NPs and NP-derived compounds that have undergone clinical evaluation or registration from 2005 to 2010 by disease area i.e. infectious (bacterial, fungal, parasitic and viral), immunological, cardiovascular, neurological, inflammatory and related diseases and oncology.
authors: Department of Chemistry, Centre of Advanced Study, Banaras Hindu University, Varanasi 221005, India.
authors: Bhuwan B
authors: BB
authors: Mishra
authors: Vinod K
authors: VK
authors: Tiwari
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D002317:Cardiovascular Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000188:drug therapy; D003141:Communicable Diseases / Q000188:drug therapy; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D008659:Metabolic Diseases / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy; D009422:Nervous System Diseases / Q000188:drug therapy; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D001688:Biological Products; D002317:Cardiovascular Agents; D010936:Plant Extracts