title: Effect of amniotic membrane to reduce postlaminectomy epidural adhesion on a rat model.
abstract: OBJECTIVE
  Epidural fibrosis and adhesion are the main reasons for post-laminectomy sustained pain and functional disability. In this study, the authors investigate the effect of irradiated freeze-dried human amniotic membrane on reducing epidural adhesion after laminectomy on a rat model.
  
  
  METHODS
  A total of 20 rats were divided into two groups. The group A did not receive human amniotic membrane implantation after laminectomy and group B underwent human amniotic membrane implantation after laminectomy. Gross and microscopic findings were evaluated and compared at postoperative 1, 3 and 8 weeks.
  
  
  RESULTS
  The amount of scar tissue and tenacity were reduced grossly in group of rats with human amniotic membrane implantation (group B). On a microscopic evaluation, there were less inflammatory cell infiltration and fibroblast proliferation in group B.
  
  
  CONCLUSIONS
  This experimental study shows that implantation of irradiated freeze-dried human amniotic membrane reduce epidural fibrosis and adhesion after spinal laminectomy in a rat model.
authors: Department of Neurosurgery, College of Medicine, Dong-A University, Busan, Korea.
authors: Hyu Jin
authors: HJ
authors: Choi
authors: Kyoung Beom
authors: KB
authors: Kim
authors: Young-Min
authors: YM
authors: Kwon