title: A generic organ based ontology system, applied to vertebrate heart anatomy, development and physiology.
abstract: We present a novel approach to modelling biological information using ontologies. The system interlinks three ontologies, comprising anatomical, developmental and taxonomical information, and includes instances of structures for different species. The framework is constructed for comparative analyses in the field of evolutionary development. We have applied the approach to the vertebrate heart and present four case studies of the functionality of the system, focusing on cross-species comparisons, developmental studies, physiological studies and 3D visualisation.
authors: Imaging & Bioinformatics, LIACS, Leiden University, The Netherlands.
authors: Laura M F
authors: LM
authors: Bertens
authors: Joris
authors: J
authors: Slob
authors: Fons J
authors: FJ
authors: Verbeek
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods*; D006321:Heart / Q000033:anatomy & histology* / Q000254:growth & development / Q000502:physiology*; D009928:Organ Specificity; D057386:Search Engine; D013045:Species Specificity; D014584:User-Computer Interface; D014714:Vertebrates / Q000033:anatomy & histology*