title: Reverse orthogonal strategy for oligosaccharide synthesis.
abstract: Herein, we report the invention of a novel expeditious concept for oligosaccharide synthesis. Unlike the classic orthogonal strategy based on leaving groups, the reverse approach is based on orthogonal protecting groups, herein p-methoxybenzyl and 4-pentenoyl, which allows for efficient oligosaccharide assembly in the reverse direction.
authors: Department of Chemistry and Biochemistry, University of Missouri-St. Louis, One University Boulevard, St. Louis, Missouri 63121, USA.
authors: Kohki
authors: K
authors: Fujikawa
authors: N Vijaya
authors: NV
authors: Ganesh
authors: Yih Horng
authors: YH
authors: Tan
authors: Keith J
authors: KJ
authors: Stine
authors: Alexei V
authors: AV
authors: Demchenko
mesh_terms: D006027:Glycosides / Q000737:chemistry; D006031:Glycosylation; D008698:Mesylates / Q000737:chemistry; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D006027:Glycosides; D008698:Mesylates; D009844:Oligosaccharides; C012077:trifluoromethanesulfonic acid