title: Lyme borreliosis.
abstract: Lyme borreliosis (Lyme disease) is caused by spirochaetes of the Borrelia burgdorferi sensu lato species complex, which are transmitted by ticks. The most common clinical manifestation is erythema migrans, which eventually resolves, even without antibiotic treatment. However, the infecting pathogen can spread to other tissues and organs, causing more severe manifestations that can involve a patient's skin, nervous system, joints, or heart. The incidence of this disease is increasing in many countries. Laboratory evidence of infection, mainly serology, is essential for diagnosis, except in the case of typical erythema migrans. Diagnosed cases are usually treated with antibiotics for 2-4 weeks and most patients make an uneventful recovery. No convincing evidence exists to support the use of antibiotics for longer than 4 weeks, or for the persistence of spirochaetes in adequately treated patients. Prevention is mainly accomplished by protecting against tick bites. There is no vaccine available for human beings.
authors: Medical University of Vienna, Institute for Hygiene and Applied Immunology, Vienna, Austria. gerold.stanek@meduniwien.ac.at
authors: Gerold
authors: G
authors: Stanek
authors: Gary P
authors: GP
authors: Wormser
authors: Jeremy
authors: J
authors: Gray
authors: Franc
authors: F
authors: Strle
mesh_terms: D006801:Humans; D008193:Lyme Disease / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy / Q000635:transmission