title: Which metabolic syndrome criteria best predict the presence of non-alcoholic fatty liver disease?
abstract: OBJECTIVE
  To know which MS criteria best predict the presence of NAFLD and the prevalences of metabolic syndrome (MS) and non-alcoholic fatty liver disease (NAFLD) diagnosed ultrasonographically among pre-diabetic and diabetic subjects based on three different MS criteria (IDF, ATP III, WHO).
  
  
  METHODS
  Subjects were screened and those with a fasting serum glucose level ≥100 mg/dL were further tested with a 75 g oral glucose tolerance test. And those who were newly diagnosed as having pre-diabetes or diabetes were evaluated for MS and NAFLD. We compared the risk ratios of NAFLD among three MS criteria using multivariate and multiple logistic regression analyses.
  
  
  RESULTS
  A total of 1365 subjects (977 males, mean age 48.4±9.5 years) were analyzed. The WHO criteria produced the highest prevalence of MS in both the pre-diabetic (49.8%) and diabetic (58.9%) groups. The IDF criteria produced the highest odds ratio for NAFLD in both pre-diabetic (3.89 [95% CI 2.75-5.51]) and diabetic (5.53 [95% CI 3.21-9.52]) groups.
  
  
  CONCLUSIONS
  The prevalence of MS depends on the set of diagnostic criteria used. IDF criteria best predicts the presence of NAFLD. The presence of NAFLD should be considered as a component of the diagnostic criteria for MS.
authors: Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors: Hyun Il
authors: HI
authors: Seo
authors: Yong Kyun
authors: YK
authors: Cho
authors: Won Young
authors: WY
authors: Lee
authors: Eun Jung
authors: EJ
authors: Rhee
authors: Ki Chul
authors: KC
authors: Sung
authors: Bum Soo
authors: BS
authors: Kim
authors: Byung Ho
authors: BH
authors: Son
authors: Jun Ho
authors: JH
authors: Shin
authors: Kwan Joong
authors: KJ
authors: Joo
authors: Hyun Pyo
authors: HP
authors: Hong
authors: Seoung Wan
authors: SW
authors: Chae
authors: Wook
authors: W
authors: Jin
mesh_terms: D000328:Adult; D015992:Body Mass Index; D005234:Fatty Liver / Q000000981:diagnostic imaging / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000000981:diagnostic imaging / Q000453:epidemiology*; D008875:Middle Aged; D011236:Prediabetic State / Q000000981:diagnostic imaging / Q000453:epidemiology*; D011237:Predictive Value of Tests; D015995:Prevalence; D014463:Ultrasonography