title: Intermittent arm ischemia induces vasodilatation of the contralateral upper limb.
abstract: Intermittent arm ischemia before percutaneous coronary intervention induces remote ischemic preconditioning (RIPC) and attenuates myocardial injury in patients with myocardial infarction. Several studies have shown that intermittent arm ischemia increases coronary flow and is related to autonomic nerve system. The aim of this study was to determine whether intermittent arm ischemia induces vasodilatation of other arteries and to assess changes in the autonomic nerve system during intermittent arm ischemia in humans. We measured change in the right brachial artery diameter during intermittent left arm ischemia through three cycles of 5-min inflation (200 mmHg) and 5-min deflation of a blood-pressure cuff using a 10-MHz linear array transducer probe in 20 healthy volunteers. We simultaneously performed power spectral analysis of heart rate. Ischemia-reperfusion of the left arm significantly dilated the right brachial artery time-dependently, resulting in a 3.2 ± 0.4% increase after the 3rd cycle. In the power spectral analysis of heart rate, the high-frequency domain (HF), which is a marker of parasympathetic activity, was significantly higher after the 3rd cycle of ischemia-reperfusion than baseline HF (P = 0.02). Intermittent arm ischemia was accompanied by vasodilatation of another artery and enhancement of parasympathetic activity. Those effects may play an important role in the mechanism of RIPC.
authors: Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan. en9422@yahoo.co.jp
authors: Kenki
authors: K
authors: Enko
authors: Kazufumi
authors: K
authors: Nakamura
authors: Kei
authors: K
authors: Yunoki
authors: Toru
authors: T
authors: Miyoshi
authors: Satoshi
authors: S
authors: Akagi
authors: Masashi
authors: M
authors: Yoshida
authors: Norihisa
authors: N
authors: Toh
authors: Mutsuko
authors: M
authors: Sangawa
authors: Nobuhiro
authors: N
authors: Nishii
authors: Satoshi
authors: S
authors: Nagase
authors: Kunihisa
authors: K
authors: Kohno
authors: Hiroshi
authors: H
authors: Morita
authors: Kengo F
authors: KF
authors: Kusano
authors: Hiroshi
authors: H
authors: Ito
mesh_terms: D000328:Adult; D001132:Arm / Q000098:blood supply*; D001341:Autonomic Nervous System / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D001916:Brachial Artery / Q000294:innervation* / Q000503:physiopathology*; D003326:Coronary Circulation / Q000502:physiology; D004562:Electrocardiography / Q000379:methods; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D015427:Reperfusion Injury / Q000503:physiopathology; D014664:Vasodilation / Q000502:physiology*; D055815:Young Adult