title: Ribosomal protein metallopanstimulin-1 impairs multiple myeloma CAG cells growth and inhibits fibroblast growth factor receptor 3.
abstract: BACKGROUND
  It was demonstrated that metallopanstimulin-1 (MPS-1, RPS27) inhibited the growth of tumors formed by head and neck squamous cell carcinoma cells and reduced paxillin gene expression.
  
  
  METHODS
  The present study examined whether and how MPS-1 affects another type of cancer, multiple myeloma (CAG). Enhanced expression of MPS-1 dramatically inhibited CAG in vitro and in vivo.
  
  
  RESULTS
  Overexpression of MPS-1 resulted in decreased fibroblast growth factor (FGF2) receptor 3 and impaired endogenous MAPK/ErK signaling. MAPK/ErK signaling was not stimulated by adding recombinant FGF2 to myeloma cells overexpressing MPS-1.
  
  
  CONCLUSIONS
  These data suggest that MPS-1 suppresses CAG growth and that weakened FGF2 signaling may contribute to this effect.
authors: Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, USA.
authors: Yuemeng
authors: Y
authors: Dai
authors: Spencer
authors: S
authors: Pierson
authors: Cross
authors: C
authors: Dudney
authors: Yuxin
authors: Y
authors: Zeng
authors: Veronica
authors: V
authors: Macleod
authors: John D
authors: JD
authors: Shaughnessy
authors: Brendan C
authors: BC
authors: Stack
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D048708:Cell Growth Processes / Q000502:physiology; D045744:Cell Line, Tumor; D017077:Culture Media, Conditioned; D005346:Fibroblast Growth Factors / Q000378:metabolism; D020869:Gene Expression Profiling; D006801:Humans; D020935:MAP Kinase Signaling System; D008297:Male; D008667:Metalloproteins / Q000096:biosynthesis* / Q000235:genetics / Q000494:pharmacology; D051379:Mice; D008819:Mice, Nude; D009101:Multiple Myeloma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D009687:Nuclear Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000494:pharmacology; D016601:RNA-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000494:pharmacology; D051498:Receptor, Fibroblast Growth Factor, Type 3 / Q000037:antagonists & inhibitors* / Q000096:biosynthesis / Q000235:genetics; D012269:Ribosomal Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000494:pharmacology; D015398:Signal Transduction; D014162:Transfection; D014183:Transplantation, Heterologous
chemical_list: D017077:Culture Media, Conditioned; D008667:Metalloproteins; D009687:Nuclear Proteins; D016601:RNA-Binding Proteins; C083686:RPS27 protein, human; D012269:Ribosomal Proteins; D005346:Fibroblast Growth Factors; D051498:Receptor, Fibroblast Growth Factor, Type 3