title: Age as prognostic factor in patients with osteosarcoma.
abstract: Age at diagnosis is a well known prognostic factor in many different malignancies; its significance for patients with osteosarcoma is however controversial. To gain more insight in the prognostic role of age, we performed a retrospective study at our institute. We included 102 patients with de-novo osteosarcoma and formed three age groups to evaluate age specific survival rates: ≤ 14 years, 15-19 years and 20-40 years. Differences in outcome between patients aged 15-19 years treated at either the pediatric department or the adult department of oncology were evaluated. The 5-year overall survival rate (OSR) of the whole population was 53.5%±1.5%. OSR of 70.6%±0.8% was seen in patients ≤ 14 years old, 52.5%±1.1% in patients 15-19 years old and 33.3%±0.9% in the patients aged 20-40 years (p=0.01). Significant differences were observed with regard to stage at presentation (higher in older age groups), size of the tumor (larger in younger age groups) and histological response (more good responders in younger age groups). No significant difference was seen between outcomes of patients aged 15-19 years treated at the pediatric or adult oncology department. In conclusion, younger patients have a significantly better outcome than older patients.
authors: Department of Pediatric Hematology and Oncology, Radboud University Nijmegen Medical Centre, 6500HB Nijmegen, The Netherlands. MM.Hagleitner@cukz.umcn.nl
authors: Melanie M
authors: MM
authors: Hagleitner
authors: Peter M
authors: PM
authors: Hoogerbrugge
authors: Winette T A
authors: WT
authors: van der Graaf
authors: Uta
authors: U
authors: Flucke
authors: H W Bart
authors: HW
authors: Schreuder
authors: D Maroeska W M
authors: DM
authors: te Loo
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000375:Aging / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D009426:Netherlands / Q000453:epidemiology; D012516:Osteosarcoma / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology* / Q000601:surgery; D011379:Prognosis; D016016:Proportional Hazards Models; D012008:Recurrence; D055815:Young Adult