title: Use of annual ABPM, and repeated carotid scan and echocardiography to monitor cardiovascular health over nine yr in pediatric and young adult renal transplant recipients.
abstract: In adult hypertensive patients, increased cIMT and LVH are independent risk factors for cardiovascular events. We have previously observed that in pediatric RTRs with tight control of BP, cIMT did not progress over time. This investigation is an extension of the aforementioned study aimed at re-examining cIMT and also reporting serial echocardiography results. Twenty-two RTRs aged 9.4 ± 3.3 yr at their baseline carotid scan underwent two additional vascular ultrasounds during a follow-up of 9.1 ± 0.9 yr. Carotid scan and echocardiography examinations were carried out simultaneously with ABPM. Antihypertensive therapy was determined according to the recipient's ABPM results, which were performed at yearly intervals. Baseline cIMT was significantly greater in RTRs than in healthy controls. There was no statistical evidence of systematic changes in cIMT over time. At the last examination, 14 of 17 RTRs with treated hypertension had controlled hypertension (prevalence 82%; 95% CI, 56.5-96.2), and the overall prevalence of LVH was 4.5% (95% CI, -0.01 to 23.5). The lack of progression of cIMT over time and the low prevalence of LVH might reflect the effect of long-standing BP control.
authors: Department of Clinical Physiology, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden.
authors: Rita
authors: R
authors: Balzano
authors: Ylva Tranaeus
authors: YT
authors: Lindblad
authors: Georgios
authors: G
authors: Vavilis
authors: Tomas
authors: T
authors: Jogestrand
authors: Ulla B
authors: UB
authors: Berg
authors: Rafael T
authors: RT
authors: Krmar
mesh_terms: D000293:Adolescent; D000959:Antihypertensive Agents / Q000494:pharmacology; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods*; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000503:physiopathology*; D002339:Carotid Arteries / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D004452:Echocardiography / Q000379:methods*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000628:therapy; D008297:Male; D015995:Prevalence; D012307:Risk Factors; D055815:Young Adult
chemical_list: D000959:Antihypertensive Agents