title: High-dose oral fluconazole therapy effective for cutaneous leishmaniasis due to Leishmania (Vianna) braziliensis.
abstract: We report for the first time the successful use of fluconazole to treat cutaneous leishmaniasis due to Leishmania braziliensis. We used escalating doses from 5 to 8 mg/kg per day. At a dose of 5 mg/kg per day, 75% patients were cured, and at 8 mg/kg per day, the cure rate was 100%. Fluconazole was well tolerated.
authors: Department of Internal Medicine, School of Medicine, Federal University of Ceará,Fortaleza, Ceará, Brazil. aqsousa@gmail.com
authors: Anastácio Q
authors: AQ
authors: Sousa
authors: Mércia S
authors: MS
authors: Frutuoso
authors: Elisabete A
authors: EA
authors: Moraes
authors: Richard D
authors: RD
authors: Pearson
authors: Margarida M L
authors: MM
authors: Pompeu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000981:Antiprotozoal Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007892:Leishmania braziliensis / Q000187:drug effects* / Q000302:isolation & purification*; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy* / Q000469:parasitology*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000981:Antiprotozoal Agents; D015725:Fluconazole