title: The disequilibrium of nucleosomes distribution along chromosomes plays a functional and evolutionarily role in regulating gene expression.
abstract: To further understand the relationship between nucleosome-space occupancy (NO) and global transcriptional activity in mammals, we acquired a set of genome-wide nucleosome distribution and transcriptome data from the mouse cerebrum and testis based on ChIP (H3)-seq and RNA-seq, respectively. We identified a nearly consistent NO patterns among three mouse tissues--cerebrum, testis, and ESCs--and found, through clustering analysis for transcriptional activation, that the NO variations among chromosomes are closely associated with distinct expression levels between house-keeping (HK) genes and tissue-specific (TS) genes. Both TS and HK genes form clusters albeit the obvious majority. This feature implies that NO patterns, i.e. nucleosome binding and clustering, are coupled with gene clustering that may be functionally and evolutionarily conserved in regulating gene expression among different cell types.
authors: The CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
authors: Peng
authors: P
authors: Cui
authors: Qiang
authors: Q
authors: Lin
authors: Lingfang
authors: L
authors: Zhang
authors: Feng
authors: F
authors: Ding
authors: Chengqi
authors: C
authors: Xin
authors: Daoyong
authors: D
authors: Zhang
authors: Fanglin
authors: F
authors: Sun
authors: Songnian
authors: S
authors: Hu
authors: Jun
authors: J
authors: Yu
mesh_terms: D000818:Animals; D016000:Cluster Analysis; D019143:Evolution, Molecular; D005786:Gene Expression Regulation; D020043:Genes, Essential / Q000235:genetics; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009707:Nucleosomes / Q000378:metabolism*; D009928:Organ Specificity / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D009707:Nucleosomes