title: Surgical management of sporadic medullary thyroid cancer.
abstract: Inherited and sporadic medullary thyroid cancer (MTC) is a rare carcinoma. Sporadic MTCs represent 70% of cases. Diagnosis is currently made with the routine use of serum calcitonin (CT) measurements to screen patients with nodular thyroid disease. Surgery is the only curative treatment of MTC and since cervical lymph nodes metastases are frequent and can occur at an early stage, a standardized lymph node dissection should be associated to total thyroidectomy. However, the extent of lymphadenectomy remains debated. Prognosis of MTC is related to both the stage of the disease and the extent of initial surgery. When tumor remnants persist after surgery, there are very few therapeutic alternatives, and these are generally of limited curative value.
authors: Service de chirurgie générale, digestive et endocrinienne, hôpital de La Pitié-Salpêtrière, université Paris-6, 47-83, boulevard de l'Hôpital, 75013 Paris, France.
authors: S
authors: S
authors: Noullet
authors: C
authors: C
authors: Trésallet
authors: G
authors: G
authors: Godiris-Petit
authors: C
authors: C
authors: Hoang
authors: L
authors: L
authors: Leenhardt
authors: F
authors: F
authors: Menegaux
mesh_terms: D002116:Calcitonin / Q000097:blood; D018276:Carcinoma, Medullary / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D011379:Prognosis; D015996:Survival Rate; D013964:Thyroid Neoplasms / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D013965:Thyroidectomy / Q000379:methods*
chemical_list: D002116:Calcitonin