title: Hidden immunotherapy targets challenge dogma.
abstract: In this issue of Science Translational Medicine, Guo et al. discuss the intriguing possibility that intracellular tumor antigen-specific monoclonal antibodies (mAbs) inhibit tumor growth and metastasis and prolong survival of tumor-bearing mice. Here, I discuss the implications of using intracellular targets in mAb-based immunotherapy as well as the possible underlying mechanisms of action.
authors: University of Pittsburgh Cancer Institute, PA 15213, USA. ferrones@upmc.edu
authors: Soldano
authors: S
authors: Ferrone
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000276:immunology*; D019496:Cancer Vaccines / Q000276:immunology*; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008297:Male; D009369:Neoplasms / Q000276:immunology*; D015513:Oncogene Proteins / Q000276:immunology*; D014611:Vaccination
chemical_list: D000970:Antineoplastic Agents; D019496:Cancer Vaccines; D015513:Oncogene Proteins