title: In vivo and in vitro evidence for pleiotropic effects of levosimendan in the intensive care setting.
abstract: Levosimendan, in addition to its inotropic properties, could have anti-inflammatory and anti-oxidative properties, and can potentially decrease the deleterious effects of reactive oxygen species on the tissues. In their study, Hasslacher and colleagues provided not only in vitro but also in vivo evidence that levosimendan could preserve organ function in acute heart failure and septic-shock-induced myocardial depression via cooling down the oxidative burst of circulating cells.
authors: Department of Cardiology, Cumhuriyet University School of Medicine, Sivas, Turkey.
authors: Mehmet Birhan
authors: MB
authors: Yilmaz
authors: Alexandre
authors: A
authors: Mebazaa
mesh_terms: D002316:Cardiotonic Agents / Q000494:pharmacology*; D005260:Female; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D006835:Hydrazones / Q000494:pharmacology*; D008297:Male; D009504:Neutrophils / Q000187:drug effects*; D011724:Pyridazines / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors*; D012772:Shock, Septic / Q000503:physiopathology*; D000077464:Simendan
chemical_list: D002316:Cardiotonic Agents; D006835:Hydrazones; D011724:Pyridazines; D017382:Reactive Oxygen Species; D000077464:Simendan