title: The roles of integrins in mediating the effects of mechanical force and growth factors on blood vessels in hypertension.
abstract: Hypertension is characterized by a sustained increase in vasoconstriction and attenuated vasodilation in the face of elevated mechanical stress in the blood vessel wall. To adapt to the increased stress, the vascular smooth muscle cell and its surrounding environment undergo structural and functional changes known as vascular remodeling. Multiple mechanisms underlie the remodeling process, including increased expression of humoral factors and their receptors as well as adhesion molecules and their receptors, all of which appear to collaborate and interact in the response to pressure elevation. In this review, we focus on the interactions between integrin signaling pathways and the activation of growth factor receptors in the response to the increased mechanical stress experienced by blood vessels in hypertension.
authors: Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, 1 Hospital Drive, Columbia, MO 65212, USA.
authors: Jun-Tzu
authors: JT
authors: Chao
authors: Michael J
authors: MJ
authors: Davis
mesh_terms: D001696:Biomechanical Phenomena; D015220:Calcium Channels / Q000187:drug effects; D004730:Endothelium, Vascular / Q000187:drug effects*; D004815:Epidermal Growth Factor / Q000187:drug effects*; D066246:ErbB Receptors / Q000187:drug effects*; D005109:Extracellular Matrix / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007334:Insulin-Like Growth Factor I / Q000187:drug effects; D016023:Integrins / Q000502:physiology*; D055595:Mechanical Phenomena; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D044140:Receptor, Angiotensin, Type 1 / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D015220:Calcium Channels; D016023:Integrins; D044140:Receptor, Angiotensin, Type 1; D004815:Epidermal Growth Factor; D007334:Insulin-Like Growth Factor I; D066246:ErbB Receptors