title: Impact of intravesical hyaluronic acid and chondroitin sulfate on bladder pain syndrome/interstitial cystitis.
abstract: OBJECTIVE
  Intravesical instillations of hyaluronic acid (HA) and chondroitin sulfate (CS) may lead to regeneration of the damaged glycosaminoglycan layer in interstitial cystitis/bladder pain syndrome (IC/BPS).
  
  
  METHODS
  Twenty-two patients with IC/BPS received intravesical instillations (40 ml) of sodium HA 1.6% and CS 2.0% in 0.9% saline solution (IALURIL, IBSA) once weekly for 8 weeks, then once every 2 weeks for the next 6 months.
  
  
  RESULTS
  The score for urgency was reduced from 6.5 to 3.6 (p = 0.0001), with a reduction in pain scores from an average of 5.6 to 3.2 (p = 0.0001). The average urine volume increased from 129.7 to 162 ml (p < 0.0001), with a reduction in the number of voids in 24 h, from 14 to 11.6 (p < 0.0001). The IC Symptom and Problem Index decreased from 25.7 to 20.3 (p < 0.0001), and the Pain Urgency Frequency score, from 18.7 to 12.8 (p < 0.0001).
  
  
  CONCLUSIONS
  The treatment appeared to be effective and well tolerated in IC/BPS in this initial experience.
authors: Urology Department, IRCCS Policlinico San Matteo, Pavia, Italy. danieleporru@tin.it
authors: Daniele
authors: D
authors: Porru
authors: Fabio
authors: F
authors: Leva
authors: Alberto
authors: A
authors: Parmigiani
authors: Davide
authors: D
authors: Barletta
authors: Dimitrios
authors: D
authors: Choussos
authors: Barbara
authors: B
authors: Gardella
authors: Maria Diletta
authors: MD
authors: Daccò
authors: Rossella Elena
authors: RE
authors: Nappi
authors: Massimo
authors: M
authors: Allegri
authors: Carmine
authors: C
authors: Tinelli
authors: Carlo Maria
authors: CM
authors: Bianchi
authors: Arsenio
authors: A
authors: Spinillo
authors: Bruno
authors: B
authors: Rovereto
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000283:Administration, Intravesical; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D002809:Chondroitin Sulfates / Q000008:administration & dosage*; D018856:Cystitis, Interstitial / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D059411:Lower Urinary Tract Symptoms / Q000188:drug therapy / Q000209:etiology; D008875:Middle Aged; D010147:Pain Measurement; D011795:Surveys and Questionnaires; D014554:Urination / Q000187:drug effects; D014556:Urine; D055815:Young Adult
chemical_list: D000276:Adjuvants, Immunologic; D000893:Anti-Inflammatory Agents; D006820:Hyaluronic Acid; D002809:Chondroitin Sulfates