title: Peptides from aminoacyl-tRNA synthetases can cure the defects due to mutations in mt tRNA genes.
abstract: Recent results from several laboratories have confirmed that human and yeast leucyl- and valyl-tRNA synthetases can rescue the respiratory defects due to mutations in mitochondrial tRNA genes. In this report we show that this effect cannot be ascribed to the catalytic activity per se and that isolated domains of aminoacyl-tRNA synthetases and even short peptides thereof have suppressing effects.
authors: Department of Biology and Biotechnologies Charles Darwin, Pasteur Institute-Cenci Bolognetti Foundation and Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy. silvia.francisci@uniroma1.it
authors: Silvia
authors: S
authors: Francisci
authors: Arianna
authors: A
authors: Montanari
authors: Cristina
authors: C
authors: De Luca
authors: Laura
authors: L
authors: Frontali
mesh_terms: D000604:Amino Acyl-tRNA Synthetases / Q000378:metabolism*; D006801:Humans; D009154:Mutation; D010455:Peptides / Q000378:metabolism*; D012343:RNA, Transfer / Q000235:genetics* / Q000378:metabolism*; D015003:Yeasts
chemical_list: D010455:Peptides; D012343:RNA, Transfer; D000604:Amino Acyl-tRNA Synthetases