title: Differential roles of human striatum and amygdala in associative learning.
abstract: Although the human amygdala and striatum have both been implicated in associative learning, only the striatum's contribution has been consistently computationally characterized. Using a reversal learning task, we found that amygdala blood oxygen level-dependent activity tracked associability as estimated by a computational model, and dissociated it from the striatal representation of reinforcement prediction error. These results extend the computational learning approach from striatum to amygdala, demonstrating their complementary roles in aversive learning.
authors: Department of Psychology, New York University, New York, New York, USA. lijian@nyu.edu
authors: Jian
authors: J
authors: Li
authors: Daniela
authors: D
authors: Schiller
authors: Geoffrey
authors: G
authors: Schoenbaum
authors: Elizabeth A
authors: EA
authors: Phelps
authors: Nathaniel D
authors: ND
authors: Daw
mesh_terms: D000293:Adolescent; D000328:Adult; D000679:Amygdala / Q000098:blood supply / Q000502:physiology*; D001245:Association Learning / Q000502:physiology*; D001931:Brain Mapping; D003198:Computer Simulation; D003214:Conditioning, Classical / Q000502:physiology; D003342:Corpus Striatum / Q000098:blood supply / Q000502:physiology*; D004644:Emotions / Q000502:physiology; D005260:Female; D005712:Galvanic Skin Response / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D016013:Likelihood Functions; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010100:Oxygen / Q000097:blood; D010364:Pattern Recognition, Visual / Q000502:physiology; D010812:Physical Stimulation / Q000379:methods; D013997:Time Factors; D055815:Young Adult
chemical_list: D010100:Oxygen