title: Genomic aberrations in salivary duct carcinoma arising in Warthin tumor of parotid gland: DNA microarray and HER2 fluorescence in situ hybridization.
abstract: Carcinoma arising from Warthin tumor is extremely rare. A 79-year-old man was admitted for a firm, well-defined, 5-cm left infra-auricular mass. Aspiration cytology showed many lymphohistiocytes and oncocytes in a proteinaceous background, compatible with Warthin tumor. A left superficial parotidectomy showed a solid mass around the cyst wall. The tumor cells of the solid area were arranged as infiltrative ducts with a few foci of malignant transformation. Virtual karyotyping disclosed a complex pattern of genetic aberrations with a focal amplification in 12q14-q21.2. This chromosomal region contains the MDM2 (murine double minute) gene, which regulates p53 inactivation. HER2 fluorescence in situ hybridization showed a focal amplification. Subsequently, the patient underwent total parotidectomy and ipsilateral neck dissection for a recurrence. To our knowledge, this is the first case of salivary duct carcinoma arising from Warthin tumor. The essential molecular pathway has not been reported, we presume an important role of MDM2 amplification- P53 inactivation.
authors: Department of Pathology, Inje University, Sanggye Paik Hospital, Seoul, Korea. hjkim@paik.ac.kr
authors: Hyun-Jung
authors: HJ
authors: Kim
authors: Young Sam
authors: YS
authors: Yoo
authors: Kyeongmee
authors: K
authors: Park
authors: Ji-Eun
authors: JE
authors: Kwon
authors: Jung Yeon
authors: JY
authors: Kim
authors: Federico A
authors: FA
authors: Monzon
mesh_terms: D000235:Adenolymphoma / Q000175:diagnosis / Q000235:genetics*; D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002869:Chromosome Aberrations; D002881:Chromosomes, Human, Pair 12; D004273:DNA, Neoplasm / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D010306:Parotid Gland / Q000601:surgery; D010307:Parotid Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology*; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics; D018987:Salivary Ducts / Q000473:pathology; D012468:Salivary Gland Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000556:secondary*
chemical_list: D004273:DNA, Neoplasm; D051736:Proto-Oncogene Proteins c-mdm2; D018719:Erb-b2 Receptor Tyrosine Kinases