title: Association of Chinese medicine constitution susceptibility to diabetic nephropathy and transforming growth factor-β1 (T869C) gene polymorphism.
abstract: OBJECTIVE
  To explore the association of Chinese medicine constitution susceptibility to diabetic nephropathy (DN) and transforming growth factor (TGF)-β1 (T869C) gene polymorphism.
  
  
  METHODS
  TGF-β1 gene polymorphism detected with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was screened for 180 DN cases and 180 type 2 diabetic mellitus (T2DM) cases without combined DN. Patients with DN were surveyed epidemiologically with constitution in the Chinese medicine questionnaire (CCMQ). Binary logistic regression analysis was utilized to study the correlation between nine types of Chinese medicine constitution and TGF-β1 (T869C) gene polymorphisms.
  
  
  RESULTS
  The DN group has a higher frequency of TGF-β1 (T869C) gene polymorphism than the T2DM group, and CC/CT genotypes than the T2DM group [CC, CT, TT (DN group): 88, 87, 5 (cases) versus (T2DM group) 71, 73, 36 (cases), P<0.05]. The phlegm-dampness constitution, damp-heat constitution, and blood stasis constitution have correlations with TGF-β1 (T869C) gene polymorphism.
  
  
  CONCLUSIONS
  Chinese medicine constitutions were associated with TGF-β1 (T869C) gene polymorphism, a potential predictor of susceptibility to DN in T2DM patients.
authors: Department of Endocrinology of Hangzhou Red Cross Hospital, China.
authors: Xin
authors: X
authors: Mou
authors: Wen-hong
authors: WH
authors: Liu
authors: Dan-yang
authors: DY
authors: Zhou
authors: Ying-hui
authors: YH
authors: Liu
authors: Yong-bin
authors: YB
authors: Hu
authors: Guo-ling
authors: GL
authors: Ma
authors: Cheng-min
authors: CM
authors: Shou
authors: Jia-wei
authors: JW
authors: Chen
authors: Jin-xi
authors: JX
authors: Zhao
mesh_terms: D000368:Aged; D001824:Body Constitution / Q000235:genetics*; D003928:Diabetic Nephropathies / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006306:Health Surveys; D006801:Humans; D016015:Logistic Models; D008297:Male; D008516:Medicine, Chinese Traditional; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
chemical_list: C508960:TGFB1 protein, human; D053773:Transforming Growth Factor beta1