title: [Antagonistic effects of Lactobacillus acidophilus and Bifidobacterium adolescents on periodontalpathogens in vitro].
abstract: OBJECTIVE
  To evaluate the possible antagonistic effects of Lactobacillus acidophilus (La) and Bifidobacterium adolescents (Ba) on Porphyromonas gingivalis (Pg) and Fusobacteriurn nuclearum (Fn).
  
  
  METHODS
  Cylinder plate method was used to observe the inhibition zone formation.The suspensions of periodontal pathogens were mixed with cell free solutions of probiotics respectively, to investigate the antagonistic effect on the production of probiotics. The data were analyzed by ANOVA using SAS 9.0 software package.
  
  
  RESULTS
  La only inhibited the growth of Pg. The cell free extract of La also significantly inhibited the growth of Pg (P<0.001). There was no antagonistic effect of Ba on the two periodontal pathogens.
  
  
  CONCLUSIONS
  La strongly inhibits the growth of Pg by its metabolites. The new strategy of confining periodontal pathogens with La as ecological modulator is worthy of further study.
authors: Department of General Dentistry, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zhaojunjun@msn.com
authors: Jun-jun
authors: JJ
authors: Zhao
authors: Ke-yi
authors: KY
authors: LE
authors: Xi-ping
authors: XP
authors: Feng
authors: Li
authors: L
authors: Ma
mesh_terms: D001644:Bifidobacterium; D006801:Humans; D066298:In Vitro Techniques; D007779:Lactobacillus acidophilus; D016966:Porphyromonas gingivalis; D019936:Probiotics