title: A practical approach to new (5Z) 2-alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one derivatives.
abstract: A practical protocol for the preparation of (5Z)-2-alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one derivatives is reported. The new compounds were obtained in good yield and stereoselectivity in two steps, namely a solvent-free Knoevenagel condensation under microwave irradiation, followed by an S-alkylation reaction with various halogenoalkanes.
authors: Chemical Engineering & Molecules for Life Sciences Group, Université de Rennes 1, Sciences Chimiques de Rennes (SCR), UMR CNRS 6226, Bât. 10A, Campus de Beaulieu, Avenue du Général Leclerc, CS 74205, 35042 Rennes Cedex, France. jean-pierre.bazureau@univ-rennes1.fr
authors: Khadidja
authors: K
authors: Bourahla
authors: Ludovic
authors: L
authors: Paquin
authors: Olivier
authors: O
authors: Lozach
authors: Laurent
authors: L
authors: Meijer
authors: François
authors: F
authors: Carreaux
authors: Jean Pierre
authors: JP
authors: Bazureau
mesh_terms: D016203:CDC2 Protein Kinase / Q000037:antagonists & inhibitors / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic; D057075:Enzyme Assays; D038362:Glycogen Synthase Kinase 3 / Q000037:antagonists & inhibitors / Q000737:chemistry; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D047428:Protein Kinase Inhibitors / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D044366:Transition Temperature
chemical_list: D007093:Imidazoles; D047428:Protein Kinase Inhibitors; D016203:CDC2 Protein Kinase; D038362:Glycogen Synthase Kinase 3