title: Inhibitory effect of sodium hypochlorite and chlorhexidine digluconate in clinical isolates of Sporothrix schenckii.
abstract: The susceptibility of Sporothrix schenckii isolates from clinical cases of canine, feline and human sporotrichosis, and from the environment, was evaluated with 4% sodium hypochlorite and 6.6% chlorhexidine digluconate using the broth microdilution, agar diffusion and direct exposure techniques. The minimal inhibitory concentration was smaller than 0.8% for chlorhexidine digluconate and between 8% and 4% for sodium hypochlorite. Inhibition zones were not found in agar diffusion for sodium hypochlorite, and zones averaging 1.9 mm were found for chlorhexidine digluconate. In the direct exposure test, sodium hypochlorite demonstrated best performance at 20 min of contact, as chlorhexidine digluconate presented little antimicrobial activity.
authors: Laboratory of Infectious Diseases, Federal University of Pelotas, Brazil             Federal University of Rio Grande do Sul, Brazil.
authors: Isabel Martins
authors: IM
authors: Madrid
authors: Antonella Souza
authors: AS
authors: Mattei
authors: Rosema
authors: R
authors: Santin
authors: Angelita
authors: A
authors: dos Reis Gomes
authors: Marlete Brum
authors: MB
authors: Cleff
authors: Mário Carlos Araújo
authors: MC
authors: Meireles
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000382:microbiology*; D002415:Cats; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004283:Dog Diseases / Q000382:microbiology*; D004285:Dogs; D006801:Humans; D008826:Microbial Sensitivity Tests; D012973:Sodium Hypochlorite / Q000494:pharmacology*; D013175:Sporothrix / Q000187:drug effects* / Q000302:isolation & purification; D013174:Sporotrichosis / Q000382:microbiology* / Q000662:veterinary*
chemical_list: D012973:Sodium Hypochlorite; C010882:chlorhexidine gluconate; D002710:Chlorhexidine