title: Alteration of ethanol tolerance caused by the deficiency in the genes associated with histone deacetylase complex in budding yeast.
abstract: Upon exposure to 8% ethanol, survival and growth of yeast strains deficient in histone deacetylase complex genes was examined. Of the 18 mutants tested, the Δsir3 and Δsir4 strains showed higher resistance to ethanol, while the Δrco1, Δhos3, Δhda2, and Δhst1 strains were more sensitive than the wild type. Furthermore, these ethanol-resistant patterns varied under aerobic and anaerobic culture conditions.
authors: Department of Food Science and Technology, Faculty of Bio-Industry, Tokyo University of Agriculture Graduate School.
authors: Takao
authors: T
authors: Matsuda
authors: Shuki
authors: S
authors: Fujimura
authors: Hiroshi
authors: H
authors: Suda
authors: Yoshimi
authors: Y
authors: Matsufuji
authors: Junichi
authors: J
authors: Nakagawa
mesh_terms: D000693:Anaerobiosis / Q000235:genetics; D004361:Drug Tolerance / Q000235:genetics*; D044127:Epigenesis, Genetic; D000431:Ethanol / Q000009:adverse effects / Q000378:metabolism*; D005285:Fermentation; D005656:Fungal Proteins / Q000235:genetics*; D017353:Gene Deletion; D005838:Genotype; D005947:Glucose / Q000378:metabolism; D006655:Histone Deacetylases / Q000172:deficiency / Q000235:genetics; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000235:genetics*; D013312:Stress, Physiological / Q000187:drug effects
chemical_list: D005656:Fungal Proteins; D006657:Histones; D000431:Ethanol; D006655:Histone Deacetylases; D005947:Glucose; D010100:Oxygen