title: Copper-free intramolecular alkyne-azide cycloadditions leading to seven-membered heterocycles.
abstract: Treatment of alk-2-ynyl derivatives of enantiopure phenylglycidol with NaN(3) triggers a cascade reaction consisting of stereospecific and regioselective epoxide ring opening followed by intramolecular azide-alkyne cycloaddition under strictly metal-free conditions. This simple one-pot procedure allows a fast buildup of molecular complexity, generating a wide array of triazolooxazepinols, triazolodiazepinols, and triazolothiazepinols.
authors: Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans, 16, 43007 Tarragona, Spain.
authors: Míriam
authors: M
authors: Sau
authors: Carles
authors: C
authors: Rodríguez-Escrich
authors: Miquel A
authors: MA
authors: Pericàs