title: Up-expression of GAD65 in the amygdala of the rat model of chronic immobilization stress with elevated blood glucose.
abstract: It is considered that hypothalamus is important in the regulation of the blood glucose, but how chronic stress leads to hyperglycemia is not known. In this experiment, we used chronic immobilization stress rat as a model, and observed that only rats with increased expression of GAD65 in the amygdala had an elevated level of blood glucose. Considering there are fiber tracks between the amygdala and hypothalamus, some of which are GABAergic, this result may indicate that the change of GAD65 expression in the amygdala may be related to changes in blood glucose levels. Therefore, the amygdala may be involved in the hyperglycemic response to stress.
authors: Department of Histology, Embryology and Neurobiology, West China School of Preclinical Medicine and Forensic Medicine, Sichuan University, Chengdu, Sichuan Province, PR China.
authors: Xiao-Jing
authors: XJ
authors: Li
authors: Wei
authors: W
authors: Zhang
authors: Bing
authors: B
authors: Liang
authors: Xiang
authors: X
authors: Zheng
authors: Xue
authors: X
authors: Zhou
mesh_terms: D000679:Amygdala / Q000201:enzymology* / Q000503:physiopathology; D000818:Animals; D001786:Blood Glucose / Q000502:physiology*; D002908:Chronic Disease; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology / Q000209:etiology / Q000503:physiopathology*; D004195:Disease Models, Animal; D005968:Glutamate Decarboxylase / Q000096:biosynthesis* / Q000502:physiology; D006943:Hyperglycemia / Q000201:enzymology / Q000209:etiology / Q000503:physiopathology*; D007031:Hypothalamus / Q000201:enzymology / Q000378:metabolism* / Q000503:physiopathology; D007103:Immobilization / Q000009:adverse effects; D008297:Male; D009434:Neural Pathways / Q000201:enzymology / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013315:Stress, Psychological / Q000201:enzymology / Q000378:metabolism / Q000503:physiopathology*; D015854:Up-Regulation / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D005968:Glutamate Decarboxylase; C401141:glutamate decarboxylase 2