title: Synthesis, structure-activity relationship and in vitro biological evaluation of N-arylethyl isoquinoline derivatives as Coxsackievirus B3 inhibitors.
abstract: Currently, there is no approved antiviral drug for the infection caused by enteroviruses. A series of novel N-arylethyl isoquinoline derivatives defined with substituents on the ring A and C were designed, synthesized and evaluated in vitro for their activities against Coxsackievirus B3 (CVB3). The primary structure-activity relationship revealed that substituents on the ring A were not beneficial for the activity. Among these analogs synthesized, compound 7f bearing a methylenedioxy at the R(4) and R(5) positions afforded an anti-CVB3 activity and a reasonable selectivity index (SI=26.8); furthermore, 7f exhibited a moderate activity against enterovirus 71 (EV71) with SI value of 9.0. Thus it has been selected as an anti-enteroviral lead compound for further investigation.
authors: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
authors: Yan-Xiang
authors: YX
authors: Wang
authors: Yu-Huan
authors: YH
authors: Li
authors: Ying-Hong
authors: YH
authors: Li
authors: Rong-Mei
authors: RM
authors: Gao
authors: Hui-Qiang
authors: HQ
authors: Wang
authors: Yan-Xin
authors: YX
authors: Liu
authors: Li-Mei
authors: LM
authors: Gao
authors: Qiao-Ni
authors: QN
authors: Lu
authors: Jian-Dong
authors: JD
authors: Jiang
authors: Dan-Qing
authors: DQ
authors: Song
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D015195:Drug Design; D029822:Enterovirus B, Human / Q000187:drug effects* / Q000502:physiology; D020128:Inhibitory Concentration 50; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D007546:Isoquinolines