title: Postinfectious optic neuropathy in endemic typhus.
abstract: Endemic typhus (Rickettsia typhi), also known as murine typhus, is a flea-borne bacterial disease rarely found in most of the developed world. Known ocular manifestations linked to endemic typhus include mild vitritis, retinal lesions, and retinal vascular leakage. Optic neuropathy, however, is rarely associated with R. typhi, and postinfectious optic neuropathy is even less common. To highlight this unusual complication, we report a patient who developed postinfectious optic neuropathy a few weeks after he was successfully treated for endemic typhus.
authors: Department of Ophthalmology, The Methodist Hospital, Houston, Texas 77030, USA.
authors: Jason
authors: J
authors: Zhang
authors: Derrick
authors: D
authors: Pau
authors: Andrew G
authors: AG
authors: Lee
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000097:blood; D001766:Blindness / Q000209:etiology; D004318:Doxycycline / Q000627:therapeutic use; D015818:Eye Infections, Bacterial / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D005451:Fluorescein Angiography; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009901:Optic Nerve Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D012286:Rickettsia typhi / Q000276:immunology / Q000302:isolation & purification*; D041623:Tomography, Optical Coherence; D014437:Typhus, Endemic Flea-Borne / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D014792:Visual Acuity / Q000502:physiology
chemical_list: D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D004318:Doxycycline