title: Polymer hydrogel from carboxymethyl guar gum and carbon nanotube for sustained trans-dermal release of diclofenac sodium.
abstract: Novel carboxymethyl guar gum (CMG)-chemically modified multiwalled carbon nanotube (MCNT) hybrid hydrogels were synthesized at different MCNT levels as potential device for sustained trans-dermal release of diclofenac sodium. Spectroscopy together with morphology, thermogravimetry, and rheological studies proved relatively strong CMG-MCNT interaction at 0.5 and 1 wt% levels of MCNT whereas de-wetting was increased with higher MCNT concentration. Drug encapsulation tendency increased with addition of MCNT; maximum entrapment was noticed at 1 wt% MCNT level. Hydrogels containing 0.5, 1 and 3 wt% MCNT exhibited slower trans-dermal release than neat CMG due to slightly higher gel viscosity and more drug entrapment. Slowest but steady release was obtained from 1 wt% MCNT loaded hydrogel due to highest viscous resistance among all other hybrid nanocomposites.
authors: Department of Polymer Science and Technology, University of Calcutta, 92, APC Road, Calcutta 700009, India.
authors: Arindam
authors: A
authors: Giri
authors: Manas
authors: M
authors: Bhowmick
authors: Sagar
authors: S
authors: Pal
authors: Abhijit
authors: A
authors: Bandyopadhyay
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003692:Delayed-Action Preparations / Q000138:chemical synthesis* / Q000378:metabolism; D004008:Diclofenac / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D015194:Diffusion Chambers, Culture; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000378:metabolism; D004339:Drug Compounding / Q000379:methods*; D005685:Galactans / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D020100:Hydrogels / Q000138:chemical synthesis / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007249:Inflammation / Q000188:drug therapy; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008351:Mannans / Q000737:chemistry* / Q000378:metabolism; D037742:Nanotubes, Carbon / Q000737:chemistry; D053149:Plant Gums / Q000737:chemistry* / Q000378:metabolism; D011108:Polymers / Q000138:chemical synthesis / Q000378:metabolism; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D014783:Viscosity
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005685:Galactans; D020100:Hydrogels; D008351:Mannans; D037742:Nanotubes, Carbon; D053149:Plant Gums; D011108:Polymers; C469704:carboxymethyl guar gum; D004008:Diclofenac