title: [Pharmacokinetics of afobazole metabolite (M-11) in rats].
abstract: Pharmacokinetics of compound M-11 (main metabolite of afobazole) after administration via different routes was studied in rats. After oral and intravenous administration, M-11 exhibited weakly pronounced bioconversion with the formation of a few metabolites that could be detected in plasma samples for about 3 hours. The absolute bioavailability of M-11 after oral administration was 68.3%. It was found that M-11 was completely absorbed from gastrointestinal tract of rats and characterized by "the first pass effect", after which approximately 70% of administered dose entered the circulation. The parent substance was determined neither in urine nor in feces.
authors: D V
authors: DV
authors: Bastrygin
authors: A O
authors: AO
authors: Viglinskaia
authors: G B
authors: GB
authors: Kolyvanov
authors: A A
authors: AA
authors: Litvin
authors: P O
authors: PO
authors: Bochkov
authors: T Ia
authors: TIa
authors: Mozhaeva
authors: V P
authors: VP
authors: Zherdev
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D001008:Anxiety Disorders / Q000188:drug therapy; D019540:Area Under Curve; D001562:Benzimidazoles / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D001682:Biological Availability; D001711:Biotransformation; D002853:Chromatography, Liquid; D005243:Feces / Q000737:chemistry; D041981:Gastrointestinal Tract / Q000502:physiology; D006207:Half-Life; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D057230:Limit of Detection; D008297:Male; D009025:Morpholines / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D051381:Rats; D053719:Tandem Mass Spectrometry
chemical_list: C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D014151:Anti-Anxiety Agents; D001562:Benzimidazoles; D009025:Morpholines