title: Hydrophilic acrylic intraocular lens optic opacification in a diabetic patient.
abstract: OBJECTIVE
  To report clinicopathologic and ultrastructural feature of one opacified hydrophilic acrylic intraocular lens (IOL) explanted from a diabetic patient.
  
  
  METHODS
  A 48-year-old man underwent trans pars plana vitrectomy and phacoemulsification with implantation of a hydrophilic acrylic lens OS in November 2008. The patient complained of a marked decrease in visual acuity in May 2009 as a result of a milky opalescence of the IOL. Intraocular lens explantation and exchange were performed in August 2009, and the explanted IOL was submitted to our center for detailed pathologic, histochemical and ultrastructural evaluation. It was stained by the von Kossa method for calcium, and also underwent scanning electron microscopy and energy dispersive radiograph spectroscopy to ascertain the nature of the deposits leading to opacification.
  
  
  RESULTS
  Opacification of the IOL was found to be the cause of the decreased visual acuity. The opacification involved only the IOL optic, and the haptics was clear. Histochemical and ultrastructural analyses revealed that the opacity was caused by deposition of calcium and phosphate within the lens optic.
  
  
  CONCLUSIONS
  We believe this report of calcification of the Akreos(®) MI-60 IOL is of clinicopathological importance. Long-term follow-up of diabetic patients implanted with this IOL should be maintained by surgeons and manufacturers.
authors: Department of Ophthalmology, CHA Bundang Medical Center, CHA University, 351 Yatap-dong, Bundang-gu, Seongnam, Gyeonggi 463-712, Korea.
authors: Dae Il
authors: DI
authors: Park
authors: Sung Woo
authors: SW
authors: Ha
authors: Seong Bae
authors: SB
authors: Park
authors: Helen
authors: H
authors: Lew
mesh_terms: D000180:Acrylic Resins; D002114:Calcinosis / Q000209:etiology* / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D020878:Device Removal; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003930:Diabetic Retinopathy / Q000150:complications*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008297:Male; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D018918:Phacoemulsification; D010710:Phosphates / Q000378:metabolism; D011475:Prosthesis Failure; D013052:Spectrometry, X-Ray Emission; D014821:Vitrectomy
chemical_list: D000180:Acrylic Resins; D010710:Phosphates; D002118:Calcium