title: The alloherpesviral counterparts of interleukin 10 in European eel and common carp.
abstract: Viral interleukin 10 (IL-10) like open reading frames have been identified in several pox- and herpesviruses, including the fish herpesviruses Anguillid herpesvirus 1 (AngHV-1) and Cyprinid herpesvirus 3 (CyHV-3). European eel (Anguilla anguilla) IL-10 was sequenced, in order to compare European eel and common carp (Cyprinus carpio) IL-10 with their alloherpesviral counterparts. Homology between the virus and host IL-10 amino acid sequences is low, which is confirmed by phylogenetic analysis. However, the three dimensional structures of the fish and alloherpesviral IL-10 proteins as predicted by modeling are highly similar to human IL-10. Closely related AngHV-1 and CyHV-3 are expected to have obtained their viral IL-10 genes independently in the course of coexistence with their respective hosts. The presence and structural conservation of these alloherpesviral IL-10 genes suggest that they might play an important role in the evolution of pathogenesis.
authors: Central Veterinary Institute, Wageningen UR, P.O. Box 65, 8200 AB Lelystad, The Netherlands.
authors: Steven J
authors: SJ
authors: van Beurden
authors: Maria
authors: M
authors: Forlenza
authors: Adrie H
authors: AH
authors: Westphal
authors: Geert F
authors: GF
authors: Wiegertjes
authors: Olga L M
authors: OL
authors: Haenen
authors: Marc Y
authors: MY
authors: Engelsma
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002347:Carps / Q000235:genetics* / Q000821:virology; D016000:Cluster Analysis; D003461:Crystallography; D017931:DNA Primers / Q000235:genetics; D004267:DNA Viruses / Q000235:genetics*; D004524:Eels / Q000235:genetics* / Q000821:virology; D019143:Evolution, Molecular; D016753:Interleukin-10 / Q000737:chemistry* / Q000235:genetics*; D008957:Models, Genetic; D008958:Models, Molecular; D008969:Molecular Sequence Data; D016366:Open Reading Frames / Q000235:genetics; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D017385:Sequence Homology
chemical_list: D017931:DNA Primers; D016753:Interleukin-10