title: Von Willebrand factor and oxidative stress parameters in acute coronary syndromes.
abstract: Considering the role of von Willebrand factor (vWf) in hemostasis, and the role of oxidative stress in the development of endothelial dysfunction and atherosclerotic disease, the aim of our study was to investigate the relationship between vWf, parameters of oxidative stress and different types of acute coronary syndromes (ACS). Levels of vWf activity (vWfAct), vWf antigen (vWfAg), nitric oxide (estimated through nitrites-NO(2)-), superoxide anion radical (O(2)-), hydrogen peroxide (H2O2), index of lipid peroxidation (estimated through thiobarbituric acid reactive substances-TBARS), superoxide dismutase (SOD) and catalase (CAT) activity of 115 patients were compared with those of 40 healthy controls. ACS patients had significantly higher vWfAct and vWfAg levels, as well as TBARS levels, while their levels of NO(2)-, H2O2, SOD and CAT activities were lower than controls'. vWfAg showed high specificity and sensitivity as a test to reveal healthy or diseased subjects. Multivariant logistic regression marked only vWfAg and TBARS as parameters that were under independent effect of ACS type. The results of our study support the implementation of vWf in clinical rutine and into therapeutic targets, and suggest that ACS patients are in need of antioxidant supplementation to improve their impaired antioxidant defence.
authors: Health Centre, 32300 Gornji Milanovac, Serbia.
authors: Zoran
authors: Z
authors: Koprivica
authors: Dusica
authors: D
authors: Djordjevic
authors: Milena
authors: M
authors: Vuletic
authors: Vladimir
authors: V
authors: Zivkovic
authors: Nevena
authors: N
authors: Barudzic
authors: Nebojsa
authors: N
authors: Andjelkovic
authors: Dragan
authors: D
authors: Djuric
authors: Violeta
authors: V
authors: Iric-Cupic
authors: Jelena
authors: J
authors: Krkeljic
authors: Vladimir
authors: V
authors: Jakovljevic
mesh_terms: D054058:Acute Coronary Syndrome / Q000378:metabolism*; D000368:Aged; D002374:Catalase / Q000378:metabolism; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014841:von Willebrand Factor / Q000378:metabolism*
chemical_list: D017392:Thiobarbituric Acid Reactive Substances; D014841:von Willebrand Factor; D009569:Nitric Oxide; D006861:Hydrogen Peroxide; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase