title: Infant rotavirus vaccination may provide indirect protection to older children and adults in the United States.
abstract: Following the introduction of rotavirus vaccination in the United States, rotavirus and cause-unspecified gastroenteritis discharges significantly decreased in 2008 in the 0-4, 5-14, and 15-24-year age groups, with significant reductions observed in March, the historic peak rotavirus month, in all age groups. We estimate that 15% of the total 66 000 averted hospitalizations and 20% of the $204 million in averted direct medical costs attributable to the vaccination program were among unvaccinated 5-24 year-olds. This study demonstrates a previously unrecognized burden of severe rotavirus in the population >5 years and the primacy of very young children in the transmission of rotavirus.
authors: Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. blopman@cdc.gov
authors: Ben A
authors: BA
authors: Lopman
authors: Aaron T
authors: AT
authors: Curns
authors: Catherine
authors: C
authors: Yen
authors: Umesh D
authors: UD
authors: Parashar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000191:economics / Q000821:virology; D005260:Female; D005759:Gastroenteritis / Q000191:economics / Q000821:virology; D006760:Hospitalization / Q000191:economics / Q000706:statistics & numerical data; D006801:Humans; D032521:Immunity, Herd / Q000276:immunology*; D007223:Infant; D008297:Male; D008875:Middle Aged; D012401:Rotavirus / Q000276:immunology; D012400:Rotavirus Infections / Q000191:economics / Q000276:immunology* / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000627:therapeutic use*; D013997:Time Factors; D014481:United States; D014611:Vaccination / Q000191:economics; D055815:Young Adult
chemical_list: D022243:Rotavirus Vaccines