title: Ginsenoside Re: pharmacological effects on cardiovascular system.
abstract: Ginsenosides are the bioactive constituents of ginseng, a key herb in traditional Chinese medicine. As a single component of ginseng, ginsenoside Re (G-Re) belongs to the panaxatriol group. Many reports demonstrated that G-Re possesses the multifaceted beneficial pharmacological effects on cardiovascular system. G-Re has negative effect on cardiac contractility and autorhythmicity. It causes alternations in cardiac electrophysiological properties, which may account for its antiarrhythmic effect. In addition, G-Re also exerts antiischemic effect and induces angiogenic regeneration. In this review, we first outline the chemistry and the pharmacological effects of G-Re on the cardiovascular system.
authors: Section of Cardiology, Internal Medicine, JiShuiTan Hospital, Beijing 100035, China.
authors: Lu
authors: L
authors: Peng
authors: Shi
authors: S
authors: Sun
authors: Lai-Hua
authors: LH
authors: Xie
authors: Sheila M
authors: SM
authors: Wicks
authors: Jing-Tian
authors: JT
authors: Xie
mesh_terms: D000200:Action Potentials; D043925:Angiogenesis Inducing Agents / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D002316:Cardiotonic Agents / Q000494:pharmacology; D002317:Cardiovascular Agents / Q000737:chemistry / Q000494:pharmacology*; D002319:Cardiovascular System / Q000187:drug effects* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D036145:Ginsenosides / Q000737:chemistry / Q000494:pharmacology*; D006329:Heart Conduction System / Q000187:drug effects / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects; D018919:Neovascularization, Physiologic / Q000187:drug effects
chemical_list: D043925:Angiogenesis Inducing Agents; D000889:Anti-Arrhythmia Agents; D002316:Cardiotonic Agents; D002317:Cardiovascular Agents; D036145:Ginsenosides; C049864:ginsenoside Re