title: Pharmacokinetic, tissue distribution and excretion of ginsenoside-Rd in rodents.
abstract: Ginsenoside-Rd (GS-Rd) is one of the major active components of Panax ginseng, and was shown to have the protective effects against several insults. However, we still lack some basic knowledge of GS-Rd, including its pharmacokinetic, tissue distribution and excretion in vivo in experimental animal, such as mice and rats. In this study, HPLC and radioactive tracer assays were performed to determine pharmacokinetic, tissue distribution and excretion of GS-Rd in rodents. After intravascular administration with 20, 50 or 150 mg/kg GS-Rd, the dynamic changes of GS-Rd concentrations in plasma were consistent with a two-compartment model while the concentration of ³H-labeled GS-Rd was rapidly reached the peak in plasma, and distributed to various tissues, among which the highest concentration was observed in the lung.
authors: Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors: Dong
authors: D
authors: Sun
authors: Bing
authors: B
authors: Wang
authors: Ming
authors: M
authors: Shi
authors: Yun-Xia
authors: YX
authors: Zhang
authors: Lin-Fu
authors: LF
authors: Zhou
authors: Zhi-Rong
authors: ZR
authors: Liu
authors: Zhong-Liang
authors: ZL
authors: Wu
authors: Wen
authors: W
authors: Jiang
authors: Jun-Liang
authors: JL
authors: Han
authors: Li-Ze
authors: LZ
authors: Xiong
authors: Gang
authors: G
authors: Zhao
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics; D005260:Female; D036145:Ginsenosides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006859:Hydrogen / Q000737:chemistry; D016014:Linear Models; D008099:Liver / Q000737:chemistry; D008168:Lung / Q000737:chemistry; D008297:Male; D051379:Mice; D005894:Panax / Q000737:chemistry; D010949:Plasma / Q000737:chemistry*; D011849:Radioactive Tracers; D011868:Radioisotopes / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
chemical_list: D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; D011849:Radioactive Tracers; D011868:Radioisotopes; D006859:Hydrogen; C049863:ginsenoside Rd