title: Aqueous and Methanolic Extracts ofCaulerpa mexicanaSuppress Cell Migration and Ear Edema Induced by Inflammatory Agents.
abstract: The regulation of the inflammatory response is essential to maintaining homeostasis. Several studies have investigated new drugs that may contribute to avoiding or minimizing excessive inflammatory process. The aim of this study was to evaluate the effect of extracts of green algae Caulerpa mexicana on models inflammation. In mice, the inflammatory peritonitis model is induced by zymosan. Previous treatment of mice with aqueous and methanolic extracts of C. mexicana was able to suppress the cell migration to the peritoneal cavity, in a time-dependent but not in a dose-dependent manner. The treatment of mice with C. mexicana extracts also decreased the xylene-induced ear edema, exerting strong inhibitory leukocyte migration elicited by zymosan into the air pouch. We concluded that administration of the extracts resulted in a reduction of cell migration to different sites as well as a decrease in edema formation induced by chemical irritants. This study demonstrates for the first time the anti-inflammatory effect of aqueous and methanolic extracts from the green marine algae Caulerpa mexicana.
authors: Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Avenida Salgado Filho, BR 101, University Campus, Lagoa Nova, 59078-900, Natal, RN, Brazil.
authors: Mariana Angelica Oliveira
authors: MAO
authors: Bitencourt
authors: Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Avenida Salgado Filho, BR 101, University Campus, Lagoa Nova, 59078-900, Natal, RN, Brazil.
authors: Gracielle Rodrigues
authors: GR
authors: Dantas
authors: Laboratory of Technology Pharmaceutical, Federal University of Paraiba, 58051-900, Joao Pessoa, PB, Brazil.
authors: Daysianne Pereira
authors: DP
authors: Lira
authors: Laboratory of Technology Pharmaceutical, Federal University of Paraiba, 58051-900, Joao Pessoa, PB, Brazil.
authors: Jose Maria
authors: JM
authors: Barbosa-Filho
authors: Laboratory of Marine Algae, Department of Systematics and Ecology, Federal University of Paraiba, 58051-900, Joao Pessoa, PB, Brazil.
authors: George Emmanuel Cavalcanti de
authors: GEC
authors: Miranda
authors: Laboratory of Technology Pharmaceutical, Federal University of Paraiba, 58051-900, Joao Pessoa, PB, Brazil.
authors: Barbara Viviana de Oliveira
authors: BVO
authors: Santos
authors: Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Avenida Salgado Filho, BR 101, University Campus, Lagoa Nova, 59078-900, Natal, RN, Brazil.
authors: Janeusa Trindade
authors: JT
authors: Souto
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D046068:Caulerpa / Q000737:chemistry*; D002465:Cell Movement / Q000187:drug effects*; D002478:Cells, Cultured; D000460:Chlorophyta / Q000737:chemistry; D016207:Cytokines / Q000378:metabolism; D004423:Ear; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D008264:Macrophages / Q000187:drug effects; D008297:Male; D000432:Methanol / Q000737:chemistry; D051379:Mice; D008807:Mice, Inbred BALB C; D010538:Peritonitis / Q000139:chemically induced / Q000188:drug therapy; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D014867:Water / Q000737:chemistry; D014992:Xylenes / Q000009:adverse effects; D015054:Zymosan / Q000009:adverse effects
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D010936:Plant Extracts; D014992:Xylenes; D014867:Water; D015054:Zymosan; D000432:Methanol