title: Outbreak caused by Proteus mirabilis isolates producing weakly expressed TEM-derived extended-spectrum β-lactamase in spinal cord injury patients with recurrent bacteriuria.
abstract: We performed a retrospective extended-spectrum β-lactamase (ESBL) molecular characterization of Proteus mirabilis isolates recovered from urine of spinal cord injury patients. A incorrectly detected TEM-24-producing clone and a new weakly expressed TEM-derived ESBL were discovered. In such patients, ESBL detection in daily practice should be improved by systematic use of a synergy test in strains of P. mirabilis resistant to penicillins.
authors: Service de Bactériologie-Hygiène, CHU de Nantes, Nantes, France.
authors: Lise
authors: L
authors: Cremet
authors: Pascale
authors: P
authors: Bemer
authors: Joanna
authors: J
authors: Rome
authors: Marie-Emmanuelle
authors: ME
authors: Juvin
authors: Dominique
authors: D
authors: Navas
authors: Celine
authors: C
authors: Bourigault
authors: Aurelie
authors: A
authors: Guillouzouic
authors: Nathalie
authors: N
authors: Caroff
authors: Didier
authors: D
authors: Lepelletier
authors: Nathalie
authors: N
authors: Asseray
authors: Brigitte
authors: B
authors: Perrouin-Verbe
authors: Stephane
authors: S
authors: Corvec
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001437:Bacteriuria / Q000453:epidemiology* / Q000382:microbiology; D016000:Cluster Analysis; D004196:Disease Outbreaks; D005838:Genotype; D006801:Humans; D010406:Penicillins / Q000494:pharmacology; D011512:Proteus Infections / Q000453:epidemiology* / Q000382:microbiology; D011513:Proteus mirabilis / Q000145:classification / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification*; D012008:Recurrence; D012189:Retrospective Studies; D013119:Spinal Cord Injuries / Q000150:complications*; D014556:Urine / Q000382:microbiology; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins; D001618:beta-Lactamases