title: Maintaining vaccine delivery following the introduction of the rotavirus and pneumococcal vaccines in Thailand.
abstract: Although the substantial burdens of rotavirus and pneumococcal disease have motivated many countries to consider introducing the rotavirus vaccine (RV) and heptavalent pneumococcal conjugate vaccine (PCV-7) to their National Immunization Programs (EPIs), these new vaccines could affect the countries' vaccine supply chains (i.e., the series of steps required to get a vaccine from their manufacturers to patients). We developed detailed computational models of the Trang Province, Thailand, vaccine supply chain to simulate introducing various RV and PCV-7 vaccine presentations and their combinations. Our results showed that the volumes of these new vaccines in addition to current routine vaccines could meet and even exceed (1) the refrigerator space at the provincial district and sub-district levels and (2) the transport cold space at district and sub-district levels preventing other vaccines from being available to patients who arrive to be immunized. Besides the smallest RV presentation (17.1 cm³/dose), all other vaccine introduction scenarios required added storage capacity at the provincial level (range: 20 L-1151 L per month) for the three largest formulations, and district level (range: 1 L-124 L per month) across all introduction scenarios. Similarly, with the exception of the two smallest RV presentation (17.1 cm³/dose), added transport capacity was required at both district and sub-district levels. Added transport capacity required across introduction scenarios from the provincial to district levels ranged from 1 L-187 L, and district to sub-district levels ranged from 1 L-13 L per shipment. Finally, only the smallest RV vaccine presentation (17.1 cm³/dose) had no appreciable effect on vaccine availability at sub-districts. All other RV and PCV-7 vaccines were too large for the current supply chain to handle without modifications such as increasing storage or transport capacity. Introducing these new vaccines to Thailand could have dynamic effects on the availability of all vaccines that may not be initially apparent to decision-makers.
authors.affiliation: University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America. BYL1@pitt.edu
authors.forename: Bruce Y
authors.initials: BY
authors.lastname: Lee
authors.forename: Tina-Marie
authors.initials: TM
authors.lastname: Assi
authors.forename: Korngamon
authors.initials: K
authors.lastname: Rookkapan
authors.forename: Angela R
authors.initials: AR
authors.lastname: Wateska
authors.forename: Jayant
authors.initials: J
authors.lastname: Rajgopal
authors.forename: Vorasith
authors.initials: V
authors.lastname: Sornsrivichai
authors.forename: Sheng-I
authors.initials: SI
authors.lastname: Chen
authors.forename: Shawn T
authors.initials: ST
authors.lastname: Brown
authors.forename: Joel
authors.initials: J
authors.lastname: Welling
authors.forename: Bryan A
authors.initials: BA
authors.lastname: Norman
authors.forename: Diana L
authors.initials: DL
authors.lastname: Connor
authors.forename: Rachel R
authors.initials: RR
authors.lastname: Bailey
authors.forename: Anirban
authors.initials: A
authors.lastname: Jana
authors.forename: Willem G
authors.initials: WG
authors.lastname: Van Panhuis
authors.forename: Donald S
authors.initials: DS
authors.lastname: Burke
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D022242:Pneumococcal Vaccines / Q000627:therapeutic use*; D011247:Pregnancy; D012401:Rotavirus / Q000276:immunology*; D013785:Thailand
chemical_list: D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022242:Pneumococcal Vaccines