title: [Irinotecan as second-line chemotherapy for 5-FU-resistant gastric cancer with disseminated intravascular coagulation: a case report].
abstract: A 60-year-old female was diagnosed as advanced gastric cancer with multiple bone, neck and mediastinal lymph node metastases. As a primary chemotherapy, she was treated with S-1(50 m g/body, twice daily for 4 weeks, followed by a 2- week rest). After 3 courses of S-1, she developed a disease progression with pulmonary lymphangitic carcinomatosis and disseminated intravascular coagulation(DIC). Therefore, she received second-line chemotherapy of irinotecan(CPT-11 150 mg/m2, biweekly). Within 3 weeks of starting the treatment, the clinical and laboratory signs of DIC were dramatically resolved. There have been no previous reports of irinotecan alone showing such remarkable effectiveness in a patient with 5- FU-resistant gastric cancer with DIC.
authors.affiliation: Dept. of Medical Oncology, Mie University Hospital.
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Oda
authors.forename: Toshiro
authors.initials: T
authors.lastname: Mizuno
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Hideki
authors.initials: H
authors.lastname: Nomura
authors.forename: Kanako
authors.initials: K
authors.lastname: Saito
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tamaru
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kageyama
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Katayama
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004211:Disseminated Intravascular Coagulation / Q000150:complications*; D017809:Fatal Outcome; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D000077146:Irinotecan; D008875:Middle Aged; D009367:Neoplasm Staging; D016879:Salvage Therapy; D013274:Stomach Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000077146:Irinotecan; D005472:Fluorouracil; D002166:Camptothecin