title: Design and synthesis of 2-(1, 3-dioxoisoindolin-2-yl)-N-(4-oxo-2-substitutedthiazolidin-3-yl) acetamide derivatives as potential anticonvulsant agents.
abstract: A series of 2-(1,3-dioxoisoindolin-2-yl)-N-(4-oxo-2-substitutedthiazolidin-3-yl) acetamide derivatives were designed and synthesized using appropriate synthetic route, keeping in view the structural requirement of pharmacophore and evaluated for anticonvulsant activity and CNS depressant activities in mice. The synthesized derivatives were examined in the maximal electroshock seizure (MES), subcutaneous pentylenetetrazole (sc-PTZ) induced seizure and neurotoxicity screens and were also evaluated for behavioral activity. All the tested compounds showed protection against MES test indicative of their ability to inhibit the seizure spread.
authors.affiliation: Department of Pharmaceutical Chemistry, YB Chavan College of Pharmacy, Dr Rafiq Zakaria Campus, Rauza Bagh, PB No 33, Aurangabad, Maharashtra 431001, India. ana@k.st
authors.forename: Anna Pratima G
authors.initials: AP
authors.lastname: Nikalje
authors.forename: Firoz Kalam
authors.initials: FK
authors.lastname: Khan
authors.forename: Mangesh
authors.initials: M
authors.lastname: Ghodke
mesh_terms: D000081:Acetamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D015195:Drug Design; D055772:Green Chemistry Technology; D008297:Male; D051379:Mice; D008872:Microwaves; D023382:Toxicity Tests, Acute
chemical_list: D000081:Acetamides; D000927:Anticonvulsants