title: Analysis of the effectiveness of basic fibroblast growth factor treatment on traumatic perforation of the tympanic membrane at different time points.
abstract: OBJECTIVE
  The aim of this study was to evaluate the effectiveness of basic fibroblast growth factor (bFGF) treatment on traumatic perforation of the tympanic membrane at different time points.
  
  
  METHODS
  This is a prospective clinical study.
  
  
  METHODS
  Patients with traumatic perforations of the tympanic membrane were given a treatment of gelatin sponge + bFGF at different time intervals of 3 days, 4 to 7 days, 8 to 15 days, and more than 4 weeks after the injury. Healing rate and time of perforation were also observed after 1 month.
  
  
  RESULTS
  In 147 ears, 144 (98.0%) were healed. The perforation healing rates were 98.6%, 97.6%, 96.3%, and 100%, respectively, at the following time intervals: within 3 days, 4 to 7 days, 8 to 14 days, and 2 to 4 weeks since the injury. This was quite true without any significant difference (P > .05). Meanwhile, in the small perforation healing of 120 ears, the average healing times from admission to perforation within 3 days, 4 to 7 days, and 8 to 14 days after the injury were 7.95 ± 2.07, 6.75 ± 2.67, and 4.18 ± 0.91 days, respectively. No significant difference was found among the 3 groups (P(1) < .01).
  
  
  CONCLUSIONS
  Treating traumatic perforation of the tympanic membrane using the bFGF technique at different times of admissions is quite effective.
authors.affiliation: Department of Otorhinolaryngology, Yiwu Central Hospital, Yiwu, Zhejiang, China. louzhengcai@163.com
authors.forename: Zhengcai
authors.initials: Z
authors.lastname: Lou
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Tang
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Wu
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D038781:Otoscopy; D012189:Retrospective Studies; D013997:Time Factors; D015599:Trauma Severity Indices; D016896:Treatment Outcome; D014432:Tympanic Membrane / Q000187:drug effects / Q000293:injuries* / Q000473:pathology; D018058:Tympanic Membrane Perforation / Q000188:drug therapy* / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects*; D014950:Wounds, Penetrating / Q000188:drug therapy* / Q000473:pathology; D055815:Young Adult
chemical_list: D016222:Fibroblast Growth Factor 2