title: Serum brain-derived neurotrophic factor and antidepressant-naive major depression after lung cancer diagnosis.
abstract: Previous studies have reported the existence of an association between brain-derived neurotrophic factor and major depression. However, the possible role of brain-derived neurotrophic factor in the pathophysiology of major depression after cancer diagnosis has not yet been investigated. Subjects were collected using the Lung Cancer Database project. Using the cut-off scores on the depression subscale of the Hospital Anxiety and Depression Scale (HADS-D), 81 subjects with depression (HADS-D > 10) and 81 subjects without depression (HADS-D < 5) were selected. The two groups were matched for age, sex, clinical stage and performance status. The serum brain-derived neurotrophic factor levels were measured using an enzyme-linked immunosorbent assay method. The serum brain-derived neurotrophic factor levels were not statistically different between the subjects in the depression group [29.1 (13.6) ng/ml; mean (SD)] and the non-depression group [31.4 (10.6) ng/ml] (P = 0.22). In a stratified analysis by gender, however, the mean serum brain-derived neurotrophic factor level in the depression group tended to be lower than that in the non-depression group among women (n = 24 pairs, P = 0.06). Major depression after cancer diagnosis is not associated with serum brain-derived neurotrophic factor levels.
authors.affiliation: Psycho-Oncology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa-City, Chiba, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Kobayakawa
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Inagaki
authors.forename: Maiko
authors.initials: M
authors.lastname: Fujimori
authors.forename: Kei
authors.initials: K
authors.lastname: Hamazaki
authors.forename: Tomohito
authors.initials: T
authors.lastname: Hamazaki
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Akechi
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Tsugane
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nishiwaki
authors.forename: Koichi
authors.initials: K
authors.lastname: Goto
authors.forename: Kenji
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Shigeto
authors.initials: S
authors.lastname: Yamawaki
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Uchitomi
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D007564:Japan; D008016:Life Change Events; D008175:Lung Neoplasms / Q000473:pathology / Q000523:psychology*; D008297:Male; D016555:Matched-Pair Analysis; D012737:Sex Factors
chemical_list: D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor