title: Next generation of non-mammalian blood-brain barrier models to study parasitic infections of the central nervous system.
abstract: Transmigration of neuropathogens across the blood-brain barrier is a key step in the development of central nervous system infections, making it a prime target for drug development. The ability of neuropathogens to traverse the blood-brain barrier continues to inspire researchers to understand the specific strategies and molecular mechanisms that allow them to enter the brain. The availability of models of the blood-brain barrier that closely mimic the situation in vivo offers unprecedented opportunities for the development of novel therapeutics.
authors.affiliation: Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan.
authors.forename: Ruqaiyyah
authors.initials: R
authors.lastname: Siddiqui
authors.forename: James
authors.initials: J
authors.lastname: Edwards-Smallbone
authors.forename: Robin
authors.initials: R
authors.lastname: Flynn
authors.forename: Naveed Ahmed
authors.initials: NA
authors.lastname: Khan
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000276:immunology / Q000502:physiology*; D018929:Cell Culture Techniques; D002494:Central Nervous System Infections / Q000469:parasitology* / Q000473:pathology*; D004195:Disease Models, Animal; D006801:Humans; D007313:Insecta; D010271:Parasites / Q000276:immunology / Q000472:pathogenicity*; D010272:Parasitic Diseases / Q000469:parasitology* / Q000473:pathology*