title: A multicenter, randomized, comparative study to determine the appropriate dose of lansoprazole for use in the diagnostic test for gastroesophageal reflux disease.
abstract: OBJECTIVE
  The diagnostic proton pump inhibitor test (PPI test) is a method used in diagnosing gastroesophageal reflux disease (GERD). This study aimed to determine the appropriate dose of lansoprazole for use in the diagnostic test for GERD.
  
  
  METHODS
  This study was a randomized, controlled, multicenter trial in the Daegu-Gyeongbuk area. Patients with typical reflux symptoms such as regurgitation and heartburn for at least three months were enrolled in this study. Patients were divided into two groups, the erosive reflux disease (ERD) group and the non-erosive reflux disease (NERD) group, and randomized to 14 days of treatment with lansoprazole at a dose of 15 mg, 30 mg or 60 mg once daily. The PPI test was considered positive if the patient's symptoms improved by more than 50%.
  
  
  RESULTS
  A total of 218 patients were enrolled, and analysis was performed on the 188 patients who completed the study. The PPI test was positive in 93.2% of the ERD group and 87.2% of the NERD group. A positive PPI test was observed in 91.7%, 89.4%, and 87.2% of the 15 mg, 30 mg, and 60 mg groups, respectively. Significant symptom score changes were observed starting on day 8 for the 15 mg, 30 mg, and 60 mg groups.
  
  
  CONCLUSIONS
  In this multicenter, randomized study of Korean patients, the standard dose of lansoprazole was as effective as a high dose of lansoprazole in relieving the symptoms of GERD, regardless of the presence of ERD, by day 14 of treatment.
authors.affiliation: Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea.
authors.forename: Si Hyung
authors.initials: SH
authors.lastname: Lee
authors.forename: Byung Ik
authors.initials: BI
authors.lastname: Jang
authors.forename: Seong Woo
authors.initials: SW
authors.lastname: Jeon
authors.forename: Joong Goo
authors.initials: JG
authors.lastname: Kwon
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Kim
authors.forename: Kwang-Bum
authors.initials: KB
authors.lastname: Cho
authors.forename: Chang Geun
authors.initials: CG
authors.lastname: Park
authors.forename: Chang Heon
authors.initials: CH
authors.lastname: Yang