title: [Role of polymorphous genes of xenobiotic biotransformation system in pathogenesis of occupational allergic dermatoses].
abstract: Studying genetic polymorphism of xenogiotics biotransformation system genes in patients with occupational allergic dermatoses, the authors revealed reliably higher percentage of polymorphous variants of CYP 1A1 *2C and EPHX1 A-415G genes, if compared with reference population. Combination of 3 polymorphous variants of xenobiotics biotransformation system genes (CYP 1A1, CYP3A4, EPHX1, GSTM1 and GSTT1) is characterized by earlier development, severe course and unfavorable prognosis of occupational skin condition.
authors.forename: L P
authors.initials: LP
authors.lastname: Kuz'mina
authors.forename: N I
authors.initials: NI
authors.lastname: Izmerova
authors.forename: M M
authors.initials: MM
authors.lastname: Koliaskina
mesh_terms: D000368:Aged; D000483:Alleles; D001711:Biotransformation; D016022:Case-Control Studies; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D017449:Dermatitis, Allergic Contact / Q000201:enzymology / Q000209:etiology / Q000235:genetics*; D009783:Dermatitis, Occupational / Q000201:enzymology / Q000209:etiology / Q000235:genetics*; D004851:Epoxide Hydrolases / Q000235:genetics; D005260:Female; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011379:Prognosis; D015262:Xenobiotics / Q000493:pharmacokinetics* / Q000633:toxicity
chemical_list: D015262:Xenobiotics; D003577:Cytochrome P-450 Enzyme System; D005982:Glutathione Transferase; D004851:Epoxide Hydrolases; C522330:EPHX1 protein, human