title: Good's syndrome-associated pure red cell aplasia with myelodysplastic syndrome.
abstract: We report a case of Good's syndrome-associated pure red cell aplasia (PRCA) with myelodysplastic syndrome (MDS). In this case, effector memory T (T(EM)) cells were expanded in the bone marrow. It remains uncertain whether the development of MDS was caused by the basic marrow defects or radiation therapy. However, since CD8(+) perforin(+) T(EM) cells expanded in the bone marrow, as was previously described for 3 of our patients with thymoma-associated PRCA, it is highly possible that the pathogenic mechanism of PRCA that is accompanied by thymoma is related to the expanded CD8(+) perforin(+) T(EM) cells in this MDS-complicated case.
authors.affiliation: Department of Hematology and Oncology, Division of Clinical Research, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan. nitta@hiroshima-u.ac.jp
authors.forename: Hideaki
authors.initials: H
authors.lastname: Nitta
authors.forename: Yuka
authors.initials: Y
authors.lastname: Harada
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Okikawa
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Fujii
authors.forename: Koji
authors.initials: K
authors.lastname: Arihiro
authors.forename: Akiro
authors.initials: A
authors.lastname: Kimura
authors.forename: Hironori
authors.initials: H
authors.lastname: Harada
mesh_terms: D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D003131:Combined Modality Therapy; D015897:Comorbidity; D016572:Cyclosporine / Q000627:therapeutic use; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications* / Q000628:therapy; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D009190:Myelodysplastic Syndromes / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects; D012010:Red-Cell Aplasia, Pure / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D013601:T-Lymphocytes / Q000473:pathology; D013934:Thymectomy; D013945:Thymoma / Q000150:complications* / Q000628:therapy; D013953:Thymus Neoplasms / Q000150:complications* / Q000628:therapy
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine