title: [Radiation protectors within the radiation safety system for extended duration exploration missions].
abstract: Radiation environment in extended duration exploration missions is scrutinized in the context of the probability of the risks of deterministic and stochastic effects of radiation. Though the probability of severe radiation damage due to solar flare is very low, nonetheless it is requisite that the crew must be provided with appropriate, including pharmacological safeguards. The current nomenclature of radiation protectors composes short-term agents against acute radiation damage. Among the others, preparation B-190 is distinguished by particularly high effectiveness and universal action, and good tolerance even when organism is exposed to the extreme factors of space flight Regimen of B-290 therapy alone and with combination with aminothiol preparations have been developed to render treatment following multiple solar events. Effectiveness of radioprotectors can be increased substantially by local shielding of the abdomen and pelvis. The most promising nonspecific stimulators of total resistance of organism are riboxin (inosin) and combined preparation aminotetravit as well as vitamins tocopherol and retinol. Therapy combining B-190 with riboxin and aminotetravit is also under discussion. Cytokine neipogen is also viewed as a candidate agent for early therapy. Concern is raised about possible development of chronic oxidative stress in long-duration exploration missions. Highlighted is the significance of adequate nutrition supplemented with fresh vegetables as a source of the most valuable bioflavonoids. Antioxidants L-selenomethionine and melatonin proved their effectiveness against heavy nuclei of galactic radiation. An open issue is how to make natural antioxidants beneficial to oxidative stress control and attenuation of low-intensity galactic radiation.
authors.forename: I B
authors.initials: IB
authors.lastname: Ushakov
authors.forename: M V
authors.initials: MV
authors.lastname: Vasin
mesh_terms: D000016:Abnormalities, Radiation-Induced / Q000188:drug therapy / Q000517:prevention & control*; D000975:Antioxidants / Q000627:therapeutic use*; D018480:Astronauts; D003359:Cosmic Radiation / Q000009:adverse effects; D006801:Humans; D007288:Inosine / Q000627:therapeutic use; D016273:Occupational Exposure / Q000517:prevention & control*; D016272:Occupational Health; D058958:Organs at Risk / Q000528:radiation effects; D010636:Phenols / Q000627:therapeutic use; D011829:Radiation Dosage; D011837:Radiation-Protective Agents / Q000145:classification / Q000627:therapeutic use*; D019445:Solar Activity; D016082:Solar System; D013026:Space Flight / Q000295:instrumentation* / Q000458:organization & administration; D013438:Sulfhydryl Compounds / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D010636:Phenols; D011837:Radiation-Protective Agents; D013438:Sulfhydryl Compounds; D014815:Vitamins; C086896:indralin; D007288:Inosine