title: Factors and networks that underpin early hematopoiesis.
abstract: Multiple trajectories have recently been described through which hematopoietic progenitor cells travel prior to becoming lineage-committed effectors. A wide spectrum of transcription factors has recently been identified that modulate developmental progression along such trajectories. Here we describe how distinct families of transcription factors act and are linked together to orchestrate early hematopoiesis.
authors.affiliation: Department of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, United States. murre@biomail.ucsd.edu
authors.forename: Elinore M
authors.initials: EM
authors.lastname: Mercer
authors.forename: Yin C
authors.initials: YC
authors.lastname: Lin
authors.forename: Cornelis
authors.initials: C
authors.lastname: Murre
mesh_terms: D019070:Cell Lineage; D018507:Gene Expression Regulation, Developmental; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006801:Humans; D008954:Models, Biological; D014157:Transcription Factors / Q000276:immunology*
chemical_list: D014157:Transcription Factors