title: Angina induced by 5-fluorouracil infusion in a patient with normal coronaries.
abstract: This article reviews the occurrence of angina in patients treated with 5-fluorouracil (5-FU) without significant coronary artery disease. We present a case followed by a review of the literature. A 43-year-old man with a history of colon cancer developed typical angina during intravenous infusion of 5-FU. His electrocardiogram (ECG) showed tall T waves during his angina episode. His angina and ECG changes reoccurred during a second 5-FU infusion. His coronary angiography was normal. This case is consistent with a rare occurrence of 5-FU-induced angina despite normal coronaries. Physician should be aware of this important side effect of 5-FU infusion.
authors.affiliation: Cardiovascular Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Tajik
authors.forename: Habib
authors.initials: H
authors.lastname: Saadat
authors.forename: Maryam
authors.initials: M
authors.lastname: Taherkhani
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Movahed
mesh_terms: D000328:Adult; D000787:Angina Pectoris / Q000139:chemically induced*; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D003110:Colonic Neoplasms / Q000188:drug therapy; D017023:Coronary Angiography; D003326:Coronary Circulation; D004562:Electrocardiography; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil