title: Facile synthesis and in-vitro antimalarial activity of novel α-hydroxy hydrazonates.
abstract: A series of previously unreported α-hydroxy hydrazonates were synthesized and tested for their antimalarial properties. Structure optimization of the antiplasmodially active α-hydroxy hydrazonate III furnished derivatives with strong in-vitro antimalarial activity against 3D7 strains of Plasmodium falciparum with IC(50)  values lower than 2.0 µM.
authors.affiliation: Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of Hamburg, Germany.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Khankischpur
authors.forename: Finn K
authors.initials: FK
authors.lastname: Hansen
authors.forename: Ronald
authors.initials: R
authors.lastname: Meurer
authors.forename: Tobias
authors.initials: T
authors.lastname: Mauz
authors.forename: Baerbel
authors.initials: B
authors.lastname: Bergmann
authors.forename: Rolf D
authors.initials: RD
authors.lastname: Walter
authors.forename: Detlef
authors.initials: D
authors.lastname: Geffken
mesh_terms: D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006835:Hydrazones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D010963:Plasmodium falciparum / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials; D006835:Hydrazones