title: Multicomponent synthesis of acylated short peptoids with antifungal activity against plant pathogens.
abstract: In this article, we describe the synthesis of a small library of short peptoids composed of four glycine residues and acylated with a fatty acid that showed a remarkable in vitro activity against two fungal plant pathogens. Their straightforward synthesis implied two consecutive Ugi reactions and can be efficiently extended to the construction of highly diverse libraries.
authors.affiliation: Departamento de Química Orgánica and UMYMFOR (CONICET-Facultad de Ciencias Exactas y Naturales), Universidad de Buenos Aires, Pabellón 2, Piso 3, Ciudad Universitaria, C1428EGA, Buenos Aires, Argentina.
authors.forename: Matías D
authors.initials: MD
authors.lastname: Galetti
authors.forename: Adriana M
authors.initials: AM
authors.lastname: Cirigliano
authors.forename: Gabriela M
authors.initials: GM
authors.lastname: Cabrera
authors.forename: Javier A
authors.initials: JA
authors.lastname: Ramírez
mesh_terms: D000215:Acylation; D000588:Amines / Q000737:chemistry; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005670:Fusarium / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D034444:Peptoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D010944:Plants / Q000187:drug effects* / Q000382:microbiology*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000588:Amines; D000935:Antifungal Agents; D034444:Peptoids