title: Propofol vs traditional sedative agents for endoscopic retrograde cholangiopancreatography: a meta-analysis.
abstract: OBJECTIVE
  To investigate the efficacy and safety of propofol sedation for endoscopic retrograde cholangiopancreatography (ERCP).
  
  
  METHODS
  Databases including PubMed, Embase, and the Cochrane Central Register of Controlled Trials updated as of October 2010 were searched. Main outcome measures were ERCP procedure duration, recovery time, incidence of hypotension and hypoxia.
  
  
  RESULTS
  Six trials with a total of 663 patients were included. The pooled mean difference in ERCP procedure duration between the propofol and traditional sedative agents was -8.05 (95% CI: -16.74 to 0.63), with no significant difference between the groups. The pooled mean difference in the recovery time was -18.69 (95% CI: -25.44 to -11.93), which showed a significant reduction with use of propofol sedation. Compared with traditional sedative agents, the pooled OR with propofol sedation for ERCP causing hypotension or hypoxia was 1.69 (95% CI: 0.82-3.50) and 0.90 (95% CI: 0.55-1.49), respectively, which indicated no significant difference between the groups.
  
  
  CONCLUSIONS
  Propofol sedation during ERCP leads to shorter recovery time without an increase of cardiopulmonary side effects. Propofol sedation can provide adequate sedation during ERCP.
authors.affiliation: Department of Anesthesiology and Intensive Care, Changhai Hospital, Second Military Medical University, 200433 Shanghai, China.
authors.forename: Lu-Long
authors.initials: LL
authors.lastname: Bo
authors.forename: Yu
authors.initials: Y
authors.lastname: Bai
authors.forename: Jin-Jun
authors.initials: JJ
authors.lastname: Bian
authors.forename: Ping-Shan
authors.initials: PS
authors.lastname: Wen
authors.forename: Jin-Bao
authors.initials: JB
authors.lastname: Li
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Deng
mesh_terms: D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000379:methods*; D002986:Clinical Trials as Topic; D016208:Databases, Factual; D006801:Humans; D006993:Hypnotics and Sedatives; D015742:Propofol
chemical_list: D006993:Hypnotics and Sedatives; D015742:Propofol