title: Inflammatory markers in preeclamptic patients.
abstract: BACKGROUND
  Preeclampsia is characterized by hypertension and proteinuria that begins in the second half of pregnancy. Endothelial dysfunction and trophoblastic hypoperfusion seen in preeclampsia suggested to be part of an increased maternal inflammatory response to pregnancy. In this study, we aimed to evaluate some inflammatory markers in pre-eclamptic and normotensive pregnants.
  
  
  METHODS
  The study included 36 cases with mild preeclamp-sia, 36 cases with severe preeclampsia and 33 cases of normotensive pregnant. High sensitive C-reactive protein (hsCRP) and serum amyloid A (SAA) were measured by enzyme-linked immunosorbent assays, serum procalcitonin was measured by enzyme-linked fluorescent immunassay. Mean arterial pressure (MAP) was used as an indicator of the severity of the disease.
  
  
  RESULTS
  In severe preeclampsia group hsCRP, serum amyloid A and procalcitonin levels were significantly higher than mild preeclamptic and normotensive groups. SAA and hsCRP levels were higher in mild preeclamptic group when compared with normotensive pregnant but no significant difference was found in procalcitonin between these groups. There were significant correlations betweeen hsCRP, SAA, procalcitonin and MAP.
  
  
  CONCLUSIONS
  The results confirm that inflammatory reactions are closely associated with preeclampsia.
authors.affiliation: Karaelmas University, Faculty of Medicine, Department of Biochemistry, Karaelmas University of Medicine, Zonguldak, Turkey. drcanmurat@yahoo.com
authors.forename: Murat
authors.initials: M
authors.lastname: Can
authors.forename: Eray
authors.initials: E
authors.lastname: Sancar
authors.forename: Muge
authors.initials: M
authors.lastname: Harma
authors.forename: Berrak
authors.initials: B
authors.lastname: Guven
authors.forename: Gorkem
authors.initials: G
authors.lastname: Mungan
authors.forename: Serefden
authors.initials: S
authors.lastname: Acikgoz
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D002116:Calcitonin / Q000097:blood; D015740:Calcitonin Gene-Related Peptide; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011498:Protein Precursors / Q000097:blood; D012372:ROC Curve; D000685:Serum Amyloid A Protein / Q000032:analysis
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D011498:Protein Precursors; D000685:Serum Amyloid A Protein; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide