title: Bergenia ciliata extract prevents ethylene glycol induced histopathological changes in the kidney.
abstract: The present investigation is an attempt to evaluate the effect of Bergenia ciliata extract on kidney of ethylene glycol induced urolithiasis in adult female Wistar rats. The hydro-alcoholic extract of Bergenia ciliata/standard drug cystone were administrated simultaneously at a dose of 150 and 300 mg/kg body weight/day, p.o. along with ethylene glycol (0.75% v/v) for 28 days. Significant changes were observed in body weight and absolute organ weight of ethylene glycol treated rats. Also histopathological results showed disrupted renal parenchyma, degenerative changes in glomeruli and focal calcification in glomerulo-tubular structures in ethylene glycol treated animals. Administration of Bergenia ciliata extract/cystone along with ethylene glycol showed significant protective effect in body weight and organ weight with few stray areas of calcifications in glomeruli. Moreover, Bergenia ciliata extract shows higher renoprotective index than cystone at the same dose level.
authors.affiliation: Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad - 380009, India.
authors.forename: Sarmistha
authors.initials: S
authors.lastname: Saha
authors.forename: Ramtej Jayram
authors.initials: RJ
authors.lastname: Verma
mesh_terms: D000465:Algorithms; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002129:Calcium Oxalate / Q000378:metabolism; D019855:Ethylene Glycol / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D005260:Female; D007194:India; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control*; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000627:therapeutic use; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D031995:Saxifragaceae / Q000737:chemistry*; D052878:Urolithiasis / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control*
chemical_list: D010936:Plant Extracts; D002129:Calcium Oxalate; D019855:Ethylene Glycol