title: Glaucoma in patients with corneal endothelial dystrophy.
abstract: OBJECTIVE
  The prevalence of primary open-angle glaucoma (POAG) in patients with corneal endothelial dystrophy has not been previously studied. Prevalence of POAG in patients with endothelial dystrophy was compared with that in the general population to determine the presence of a relationship between the diseases.
  
  
  METHODS
  Retrospective case-control study.
  
  
  METHODS
  A study of the prevalence of POAG in 430 eyes of 215 patients with endothelial dystrophy was conducted. Patients followed for less than 6 months were excluded. Relative risk of POAG was calculated using age- and race-matched control data from the Baltimore Eye Survey and the Los Angeles Latino Eye Survey for comparison. Ocular hypertension (OHT) and secondary glaucoma (SG) rates after penetrating keratoplasty (PK) and Descemet stripping endothelial keratoplasty (DSEK) were separately analyzed.
  
  
  RESULTS
  Relative risk of POAG in white, African American, and Hispanic patients with endothelial dystrophy was 0.94, 2.59, and 3.7, respectively (P = 0.89, 95% confidence interval [CI], -0.028 to 0.0289; P = 0.13; 95% CI, 0.011-0.274; P = 0.055; 95% CI, 0.0423-0.356). Relative risk of SG and combined OHT/SG in PK versus DSEK was 4.15 and 1.95 (P < 0.001; 95% CI, 0.0654-0.322; P = 0.005; 95% CI, 0.116-0.332), respectively. No differences in OHT/SG rates were found comparing PK-triple with PK, DSEK-triple with DSEK, and repeat with primary PK or DSEK (P = 0.98; P = 0.62; P = 0.95; P = 0.87), respectively.
  
  
  CONCLUSIONS
  No increased risk of POAG was found in patients with endothelial dystrophy. Increased prevalence of OHT/SG was shown with PK versus DSEK; possible mechanisms include mechanical closure of Schlemm's canal by running suture and prolonged steroid use.
authors.affiliation: UT Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Zahra K
authors.initials: ZK
authors.lastname: Ali
authors.forename: Jess T
authors.initials: JT
authors.lastname: Whitson
authors.forename: V Vinod
authors.initials: VV
authors.lastname: Mootha
authors.forename: S Robert
authors.initials: SR
authors.lastname: Witherspoon
authors.forename: J Arun
authors.initials: JA
authors.lastname: Joseph
authors.forename: Ashley M
authors.initials: AM
authors.lastname: Joseph
authors.forename: Linda S
authors.initials: LS
authors.lastname: Hynan
authors.forename: H Dwight
authors.initials: HD
authors.lastname: Cavanagh
mesh_terms: D001741:Black or African American; D016022:Case-Control Studies; D005260:Female; D005642:Fuchs' Endothelial Dystrophy / Q000150:complications* / Q000208:ethnology / Q000601:surgery; D005902:Glaucoma, Open-Angle / Q000453:epidemiology* / Q000208:ethnology; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D009798:Ocular Hypertension / Q000453:epidemiology / Q000208:ethnology; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D014481:United States / Q000453:epidemiology