title: [A study of association between the interleukin-1 single nucleotide polymorphism and risk of chronic periodontitis among the Hui and Dongxiang minorities in Gansu province].
abstract: OBJECTIVE
  To examine and analyze the interleukin (IL)-1B gene single nucleotide polymorphism (SNP) at positions +3954, and explore the association between SNP and risk of chronic periodontitis (CP) among the Hui and Dongxiang minorities in Gansu province.
  
  
  METHODS
  CP group consisted of 215 patients from Hui and Dongxiang and healthy control group consisted of 219 subjects. Anti-coagulated peripheral blood sample was obtained from each subject and genomic DNA was extracted from each sample. SNP at IL-1B+3954 were analyzed by standard polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay.
  
  
  RESULTS
  Statistically significant differences were found in genotype and allele frequencies between CP group and healthy control group. The exist of position alleles C increased the incidence of CP. The trend of frequency distribution of gene polymorphism above in Dongxiang was the same as that of Hui.
  
  
  CONCLUSIONS
  The present study reveals that IL-1B+3954C/T genotypes are significantly associated with the risk of CP. These results indicate that genetic polymorphism is significantly associated with the risk of CP among the Hui and Dongxiang minorities in Gansu province.
authors.affiliation: Dept. of Stomatology, Second Hospital of Lanzhou University, Lanzhou 730030, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Yang
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Xie
authors.forename: Liyang
authors.initials: L
authors.lastname: Ma
authors.forename: Zhishou
authors.initials: Z
authors.lastname: Liu
authors.forename: Yulan
authors.initials: Y
authors.lastname: Pan
authors.forename: Yanbin
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000328:Adult; D000483:Alleles; D055113:Chronic Periodontitis; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007375:Interleukin-1; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide
chemical_list: D007375:Interleukin-1