title: Leukemic phase of anaplastic lymphoma kinase positive, anaplastic large cell lymphoma.
abstract: Anaplastic large cell lymphoma (ALCL) is a distinct type of CD30+ T/null-cell non-Hodgkin's lymphoma that frequently involves nodal and extranodal sites. The presence of leukemic phase in ALCL is extremely rare and occurs exclusively with ALK1-positive ALCL. We describe two patients with ALK1-positive ALCL who developed a leukemic phase with rapid progression of the disease. Immunophenotypic pattern assessed on peripheral blood by flow cytometry revealed CD45, CD30, and CD25 positivity in both cases but NPM-ALK1 was expressed in only one case. Both patients developed leukemic phase as a terminal event of the disease and we share the immunophenotypic features of both cases.
authors.affiliation: Hematopathology of Laboratory, Tata Memorial Hospital, Mumbai, India.
authors.forename: Vijaya S
authors.initials: VS
authors.lastname: Gadage
authors.forename: P G
authors.initials: PG
authors.lastname: Subramanian
authors.forename: Komal S
authors.initials: KS
authors.lastname: Galani
authors.forename: Kunal K
authors.initials: KK
authors.lastname: Sehgal
authors.forename: Sachin P
authors.initials: SP
authors.lastname: Johari
authors.forename: Vijay S
authors.initials: VS
authors.lastname: Ghogale
authors.forename: Y
authors.initials: Y
authors.lastname: Badrinath
authors.forename: K
authors.initials: K
authors.lastname: Ashok
authors.forename: Sumeet
authors.initials: S
authors.lastname: Gujral
mesh_terms: D000293:Adolescent; D000077548:Anaplastic Lymphoma Kinase; D002648:Child; D018450:Disease Progression; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit / Q000032:analysis; D017730:Ki-1 Antigen / Q000032:analysis; D007945:Leukemia, Lymphoid / Q000175:diagnosis* / Q000473:pathology*; D017493:Leukocyte Common Antigens / Q000032:analysis; D007963:Leukocytes, Mononuclear / Q000737:chemistry; D017728:Lymphoma, Large-Cell, Anaplastic / Q000150:complications / Q000175:diagnosis* / Q000473:pathology*; D008297:Male; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*
chemical_list: C508017:IL2RA protein, human; D053645:Interleukin-2 Receptor alpha Subunit; D017730:Ki-1 Antigen; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases; D017493:Leukocyte Common Antigens; C516769:PTPRC protein, human