title: Biological evaluation of glycosyl-isoindigo derivatives against the pathogenic agents of tropical diseases (malaria, Chagas disease, leishmaniasis and human African trypanosomiasis).
abstract: The biological activities of diversely substituted glycosyl-isoindigo derivatives against the causative agents of tropical diseases (malaria, Chagas disease, leishmaniasis and human African trypanosomiasis) are reported. Some of the compounds tested showed interesting activities with good selectivity indices, particularly against Trypanosoma brucei rhodesiense. These results suggested, for the first time, that glycosyl-isoindigo derivatives could be of interest for the discovery of new lead compounds to treat tropical diseases.
authors.affiliation: Clermont Université, Université Blaise Pascal, SEESIB, BP 10448, F-63000 Clermont-Ferrand, France.
authors.forename: Fadoua
authors.initials: F
authors.lastname: Bouchikhi
authors.forename: Fabrice
authors.initials: F
authors.lastname: Anizon
authors.forename: Reto
authors.initials: R
authors.lastname: Brun
authors.forename: Pascale
authors.initials: P
authors.lastname: Moreau
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D006801:Humans; D011528:Protozoan Infections / Q000188:drug therapy*
chemical_list: D000981:Antiprotozoal Agents