title: Vestibular function and quality of life in vestibular schwannoma: does size matter?
abstract: OBJECTIVE
  Patients with vestibular schwannoma (VS) frequently suffer from disabling vestibular symptoms. This prospective follow-up study evaluates vestibular and auditory function and impairment of quality of life due to vertigo, dizziness, and imbalance in patients with unilateral VS of different sizes before/after microsurgical or radiosurgical treatment.
  
  
  METHODS
  Thirty-eight patients with unilateral VS were included. Twenty-two received microsurgery, 16 CyberKnife radiosurgery. Two follow-ups took place after a median of 50 and 186.5 days. Patients received a standardized neuro-ophthalmological examination, electronystagmography with bithermal caloric testing, and pure-tone audiometry. Quality of life was evaluated with the Dizziness Handicap Inventory (DHI). Patient data was grouped and analyzed according to the size of the VS (group 1: <20 mm vs group 2: ≥20 mm).
  
  
  RESULTS
  In group 1, the median loss of vestibular function was +10.5% as calculated by Jongkees Formula (range -43 to +52; group 2: median +36%, range -56 to +90). The median change of DHI scores was -9 in group 1 (range -68 to 30) and +2 in group 2 (-54;+20). Median loss of hearing was 4 dB (-42; 93) in group 1 and 12 dB in group 2 (5; 42).
  
  
  CONCLUSIONS
  Loss of vestibular function in VS clearly correlates with tumor size. However, loss of vestibular function was not strictly associated with a long-term deterioration of quality of life. This may be due to central compensation of vestibular deficits in long-standing large tumors. Loss of hearing before treatment was significantly influenced by the age of the patient but not by tumor size. At follow-up 1 and 2, hearing was significantly influenced by the size of the VS and the manner of treatment.
authors.affiliation: Department of Neurology, Ludwig-Maximilians University Munich, Germany.
authors.forename: Judith Nastjenka
authors.initials: JN
authors.lastname: Wagner
authors.forename: Miriam
authors.initials: M
authors.lastname: Glaser
authors.forename: Berndt
authors.initials: B
authors.lastname: Wowra
authors.forename: Alexander
authors.initials: A
authors.lastname: Muacevic
authors.forename: Roland
authors.initials: R
authors.lastname: Goldbrunner
authors.forename: Christian
authors.initials: C
authors.lastname: Cnyrim
authors.forename: Jörg-Christian
authors.initials: JC
authors.lastname: Tonn
authors.forename: Michael
authors.initials: M
authors.lastname: Strupp