title: Antimicrobial evaluation of Huilliche plant medicine used to treat wounds.
abstract: BACKGROUND
  The traditional use of 40 plant species used for treatment of wounds and associated infections by the Huilliche people of Chile was evaluated against bacterial and fungal human pathogens, especially including wound pathogens.
  
  
  METHODS
  The extracts were tested against the fungi Penicillium expansum, Candida albicans and the bacteria Bacillus subtilis, Pseudomonas aeruginosa (four different strains), Staphylococcus aureus, Escherichia coli (four different strains), Streptococcus pneumoniae (four different strains with one being resistance to streptomycin).
  
  
  RESULTS
  Thirteen of the plant species have interesting antimicrobial activities, with that of Acaena argentea, Aristotelia chilensis, Blechnum chilense, Francoa appendiculta, Gevuina avellana and Laureliopsis philippiana being the most noteworthy.
  
  
  CONCLUSIONS
  The findings in the manuscript support the traditional use by the Huilliche people, and allow enhanced economical benefit and use by the locals. The results obtained on Acaena argentea, Aristotelia chilensis, Blechnum chilense, Francoa appendiculta, Gevuina avellana and Laureliopsis philippiana are of specific scientific interest, and further studies is needed in order to establish the active constituents of the species.
authors.affiliation: Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. pm@farma.ku.dk
authors.forename: Per
authors.initials: P
authors.lastname: Mølgaard
authors.forename: Jes Gitz
authors.initials: JG
authors.lastname: Holler
authors.forename: Betül
authors.initials: B
authors.lastname: Asar
authors.forename: Iwona
authors.initials: I
authors.lastname: Liberna
authors.forename: Lise Bakkestrøm
authors.initials: LB
authors.lastname: Rosenbæk
authors.forename: Christina Ploug
authors.initials: CP
authors.lastname: Jebjerg
authors.forename: Lene
authors.initials: L
authors.lastname: Jørgensen
authors.forename: Jeanette
authors.initials: J
authors.lastname: Lauritzen
authors.forename: Alfonso
authors.initials: A
authors.lastname: Guzman
authors.forename: Anne
authors.initials: A
authors.lastname: Adsersen
authors.forename: Henrik Toft
authors.initials: HT
authors.lastname: Simonsen
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects; D002677:Chile; D004351:Drug Resistance; D020834:Ethnopharmacology; D006801:Humans; D007239:Infections / Q000188:drug therapy* / Q000382:microbiology; D008519:Medicine, Traditional; D010407:Penicillium / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal; D014947:Wounds and Injuries / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000890:Anti-Infective Agents; D010936:Plant Extracts