title: Iron administration reduces airway hyperreactivity and eosinophilia in a mouse model of allergic asthma.
abstract: The prevalence of allergic diseases has increased dramatically during the last four decades and is paralleled by a striking increase in iron intake by infants in affluent societies. Several studies have suggested a link between increased iron intake and the marked increase in prevalence of allergic diseases. We hypothesized that the increased iron intake by infants offers an explanation for the increased prevalence of allergic disease in industrialized societies during the past four decades. A well-established mouse model of ovalbumin (OVA)-driven allergic asthma was used to test the effects of differences in iron intake and systemic iron levels on the manifestations of allergic asthma. Surprisingly, iron supplementation resulted in a significant decrease in airway eosinophilia, while systemic iron injections lead to a significant suppression of both allergen-induced airway eosinophilia and hyperreactivity compared to placebo. In contrast, mice fed on an iron-deprived diet did not show any difference in developing experimentally induced allergic asthma when compared to those fed on an iron-sufficient control diet. In contrast to our hypothesis, airway manifestations of allergic asthma are suppressed by both increased levels of iron intake and systemic iron administrations in the mouse model.
authors.affiliation: Laboratory of Allergology and Pulmonary Diseases, Department of Pathology and Medical Biology, GRIAC Research Institute, University Medical Center Groningen (UMCG), University of Groningen, Groningen, the Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: Maazi
authors.forename: S
authors.initials: S
authors.lastname: Shirinbak
authors.forename: N
authors.initials: N
authors.lastname: Bloksma
authors.forename: M C
authors.initials: MC
authors.lastname: Nawijn
authors.forename: A J M
authors.initials: AJ
authors.lastname: van Oosterhout
mesh_terms: D000485:Allergens / Q000009:adverse effects / Q000276:immunology; D000818:Animals; D001249:Asthma / Q000097:blood / Q000139:chemically induced / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D016535:Bronchial Hyperreactivity / Q000097:blood / Q000139:chemically induced / Q000276:immunology; D001992:Bronchoalveolar Lavage Fluid / Q000276:immunology; D016207:Cytokines / Q000096:biosynthesis* / Q000276:immunology; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D004802:Eosinophilia / Q000097:blood / Q000139:chemically induced / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood* / Q000276:immunology; D007223:Infant; D007274:Injections, Intraperitoneal; D007501:Iron / Q000276:immunology / Q000378:metabolism / Q000494:pharmacology; D007505:Iron-Dextran Complex / Q000276:immunology / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D008297:Male; D016210:Methacholine Chloride / Q000009:adverse effects* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000009:adverse effects / Q000276:immunology; D010618:Phenanthrolines / Q000032:analysis; D010991:Plethysmography
chemical_list: D000485:Allergens; D015415:Biomarkers; D016207:Cytokines; D010618:Phenanthrolines; D016210:Methacholine Chloride; D007073:Immunoglobulin E; C006686:bathophenanthroline; D007505:Iron-Dextran Complex; D010047:Ovalbumin; D007501:Iron