title: Polymorphisms contribution to the determination of significant risk of specific toxicities in multiple myeloma.
abstract: The introduction of new drugs improved clinical response of patients with diagnosed multiple myeloma (MM); however, MM is still an incurable disease that leads to frequent relapses. Individual genetic variability can significantly affect therapeutic response, sensitivity and toxicity. Analysis of single nucleotide polymorphisms (SNPs) to study genetic changes is the genomic method that can obtain information for improving the effectiveness of treatment with minimum undesirable toxicity followed by individual treatments. The aim of this paper is to explain the possibility of detection and evaluation of polymorphisms associated with toxicity of treatment in patients with MM.
authors.affiliation: Laboratory of Experimental Hematology and Cell Immunotherapy, Department of Clinical Hematology, University Hospital Brno, Czech Republic.
authors.forename: M
authors.initials: M
authors.lastname: Almási
authors.forename: S
authors.initials: S
authors.lastname: Sevcíková
authors.forename: H
authors.initials: H
authors.lastname: Sváhová
authors.forename: B
authors.initials: B
authors.lastname: Sábláková
authors.forename: P
authors.initials: P
authors.lastname: Májková
authors.forename: R
authors.initials: R
authors.lastname: Hájek
mesh_terms: D055106:Genome-Wide Association Study; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000235:genetics*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide; D054556:Venous Thromboembolism / Q000139:chemically induced
chemical_list: D007166:Immunosuppressive Agents