title: Potential health economic impact of intravenous iron supplementation to erythropoiesis-stimulating agent treatment in patients with cancer- or chemotherapy-induced anemia.
abstract: BACKGROUND
  Intravenous (i.v.) iron supplementation significantly improves the response to erythropoiesis-stimulating agent (ESA)-based therapies in patients with cancer- or chemotherapy-induced anemia. The economic implications of adding i.v. iron to ESA treatment are less well investigated. Published randomized controlled trials do not provide sufficient data for a comprehensive cost-effectiveness analysis.
  
  
  METHODS
  Preliminary cost calculations from the Swiss health care system perspective based on a meta-analysis and published results of eight randomized controlled trials without correction for decreased ESA need provide a conservative cost-effectiveness estimate.
  
  
  RESULTS
  The additional total cost of i.v. iron supplementation ranged from EUR 417 to EUR 901 per patient depending on the evaluated iron-carbohydrate complex. Considering a 24% absolute increase in the proportion of ESA responders, the incremental cost-effectiveness ratios per additional responder are EUR 1,704-3,686. In routine practice, better values may be achieved due to ESA dose savings.
  
  
  CONCLUSIONS
  Supplementation of ESAs with i.v. iron appears to be an economically viable treatment option in anemic cancer patients. Additional research on ESA dose savings and cost-effectiveness is required.
authors.affiliation: Institute of Pharmaceutical Medicine, University of Basel, Basel, Switzerland. thomas.szucs@unibas.ch
authors.forename: T D
authors.initials: TD
authors.lastname: Szucs
authors.forename: P R
authors.initials: PR
authors.lastname: Blank
authors.forename: M
authors.initials: M
authors.lastname: Schwenkglenks
authors.forename: M
authors.initials: M
authors.lastname: Aapro
mesh_terms: D000740:Anemia / Q000139:chemically induced / Q000188:drug therapy* / Q000191:economics*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D003362:Cost-Benefit Analysis; D019587:Dietary Supplements / Q000191:economics*; D006397:Hematinics / Q000191:economics* / Q000627:therapeutic use; D006801:Humans; D007501:Iron / Q000008:administration & dosage*; D015201:Meta-Analysis as Topic; D009369:Neoplasms / Q000150:complications* / Q000188:drug therapy; D016032:Randomized Controlled Trials as Topic
chemical_list: D000970:Antineoplastic Agents; D006397:Hematinics; D007501:Iron