title: [Randomized controlled study of targeted tidal volume ventilation for treatment of severe neonatal respiratory distress syndrome].
abstract: OBJECTIVE
  To evaluate the efficacy of targeted tidal volume ventilation in the treatment of severe neonatal respiratory distress syndrome (RDS).
  
  
  METHODS
  Eighty-four neonates with severe RDS between June 2008 and January 2010 were randomly assigned to 3 groups according to the ventilation mode: synchronized intermittent positive pressure ventilation plus volume guarantee (SIPPV+VG; n=31), high frequency oscillation ventilation (HFOV; n=23) and intermittent mandatory ventilation (IMV; n=30). The oxygenation status, the durations of oxygen exposure and ventilation and the incidence of complications were observed.
  
  
  RESULTS
  The oxygenation status (P/F and a/APO2) in the SIPPV+VG and the HFOV groups was improved significantly 12 hrs after ventilation (P<0.05). While in the IMV group, the oxygenation status was not improved until 24 hrs after ventilation. The durations of oxygen exposure and ventilation in the SIPPV+VG and the HFOV groups were shorter than in the IMV group (P<0.05). The incidences of air leak syndrome and ventilation-associated pneumonia (VAP) were lower in the SIPPV+VG and the HFOV groups than in the IMV group (P<0.05). The incidence of severe intracranial hemorrhage in the HFOV group was higher than in the other two groups (P<0.05).
  
  
  CONCLUSIONS
  Compared with IMV, SIPPV+VG and HFOV can improve the oxygenation status more quickly, shorten the ventilation duration and decrease the incidences of air leak syndrome and VAP in neonates with severe RDS.
authors.affiliation: Department of Neonatology, Children's Hospital of Hebei Province, Shijiazhuang 050031, China. liu.cuiqing@gmail.com
authors.forename: Cui-Qing
authors.initials: CQ
authors.lastname: Liu
authors.forename: Ze
authors.initials: Z
authors.lastname: Cui
authors.forename: Yao-Fang
authors.initials: YF
authors.lastname: Xia
authors.forename: Li
authors.initials: L
authors.lastname: Ma
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Fan
mesh_terms: D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007384:Intermittent Positive-Pressure Breathing; D008297:Male; D012121:Respiration, Artificial; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy*; D013990:Tidal Volume