title: Results of the 2nd part Scientific Workshop of the ECCO. II: Measures and markers of prediction to achieve, detect, and monitor intestinal healing in inflammatory bowel disease.
abstract: The healing of the intestine is becoming an important objective in the management of inflammatory bowel diseases. It is associated with improved disease outcome. Therefore the assessment of this healing both in clinical studies and routine practice is a key issue. Endoscopy for the colon and terminal ileum and computerized tomography or magnetic resonance imaging for the small bowel are the most direct ways to evaluate intestinal healing. However, there are many unsolved questions about the definition and the precise assessment of intestinal healing using these endoscopic and imaging techniques. Furthermore, these are relatively invasive and expensive procedures that may be inadequate for regular patients' monitoring. Therefore, biomarkers such as C-reactive protein and fecal calprotectin have been proposed as surrogate markers for intestinal healing. Nevertheless, the sensitivity and specificity of these markers for the prediction of healing may be insufficient for routine practice. New stool, blood or intestinal biomarkers are currently studied and may improve our ability to monitor intestinal healing in the future.
authors.affiliation: Gastroenterology Division, AO Ordine Mauriziano, Torino, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Daperno
authors.forename: Fabiana
authors.initials: F
authors.lastname: Castiglione
authors.forename: Lissy
authors.initials: L
authors.lastname: de Ridder
authors.forename: Iris
authors.initials: I
authors.lastname: Dotan
authors.forename: Martti
authors.initials: M
authors.lastname: Färkkilä
authors.forename: Jon
authors.initials: J
authors.lastname: Florholmen
authors.forename: Gerald
authors.initials: G
authors.lastname: Fraser
authors.forename: Walter
authors.initials: W
authors.lastname: Fries
authors.forename: Xavier
authors.initials: X
authors.lastname: Hebuterne
authors.forename: Peter Laszlo
authors.initials: PL
authors.lastname: Lakatos
authors.forename: Julián
authors.initials: J
authors.lastname: Panés
authors.forename: Jordi
authors.initials: J
authors.lastname: Rimola
authors.forename: Edouard
authors.initials: E
authors.lastname: Louis
mesh_terms: D015415:Biomarkers / Q000032:analysis* / Q000378:metabolism; D016099:Endoscopy, Gastrointestinal; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000473:pathology / Q000503:physiopathology*; D007413:Intestinal Mucosa / Q000473:pathology / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed; D014945:Wound Healing
chemical_list: D015415:Biomarkers