title: Folic acid-conjugated silica-modified gold nanorods for X-ray/CT imaging-guided dual-mode radiation and photo-thermal therapy.
abstract: Multifunctional nanoprobes are designed to own various functions such as tumor targeting, imaging and selective therapy, which offer great promise for the future of cancer prevention, diagnosis, imaging and treatment. Herein, silica was applied to replace cetyltrimethylammonium bromide (CTAB) molecules on the surface of gold nanorods (GNRs) by the classic Stöber method, thus eliminating their cytotoxicity and improving their biocompatibility. Folic acid molecule was covalently anchored on the surface of GNRs with silane coupling agent. The resultant folic acid-conjugated silica-modified GNRs show highly selective targeting, enhanced radiation therapy (RT) and photo-thermal therapy (PTT) effects on MGC803 gastric cancer cells, and also exhibited strong X-ray attenuation for in vivo X-ray and computed tomography (CT) imaging. In conclusion, the as-prepared nanoprobe is a good candidate with excellent imaging and targeting ability for X-ray/CT imaging-guided targeting dual-mode enhanced RT and PTT.
authors.affiliation: National Key Laboratory of Nano/Micro Fabrication Technology, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, PR China.
authors.forename: Peng
authors.initials: P
authors.lastname: Huang
authors.forename: Le
authors.initials: L
authors.lastname: Bao
authors.forename: Chunlei
authors.initials: C
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Lin
authors.forename: Teng
authors.initials: T
authors.lastname: Luo
authors.forename: Dapeng
authors.initials: D
authors.lastname: Yang
authors.forename: Meng
authors.initials: M
authors.lastname: He
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Li
authors.forename: Guo
authors.initials: G
authors.lastname: Gao
authors.forename: Bing
authors.initials: B
authors.lastname: Gao
authors.forename: Shen
authors.initials: S
authors.lastname: Fu
authors.forename: Daxiang
authors.initials: D
authors.lastname: Cui
mesh_terms: D000818:Animals; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003624:Darkness; D005492:Folic Acid / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D006046:Gold / Q000008:administration & dosage / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D008819:Mice, Nude; D043942:Nanotubes / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure; D010789:Phototherapy / Q000379:methods*; D012822:Silicon Dioxide / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D017550:Spectroscopy, Fourier Transform Infrared; D040521:Subcutaneous Tissue / Q000187:drug effects; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D006046:Gold; D012822:Silicon Dioxide; D005492:Folic Acid