title: Treatment of painful osteoporotic vertebral compression fractures: a brief review of the evidence for percutaneous vertebroplasty.
abstract: Vertebral compression fractures are the most prevalent complication of osteoporosis and percutaneous vertebroplasty (PVP) has emerged as a promising addition to the methods of treating the debilitating pain they may cause. Since PVP was first reported in the literature in 1987, more than 600 clinical papers have been published on the subject. Most report excellent improvements in pain relief and quality of life. However, these papers have been based mostly on uncontrolled cohort studies with a wide variety of inclusion and exclusion criteria. In 2009, two high-profile randomised controlled trials were published in the New England Journal of Medicine which led care providers throughout the world to question the value of PVP. After more than two decades a number of important questions about the mechanism and the effectiveness of this procedure remain unanswered.
authors.affiliation: Department of Radiology, Leiden University Medical Center, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands. s.muijs@gmail.com
authors.forename: S P J
authors.initials: SP
authors.lastname: Muijs
authors.forename: A R
authors.initials: AR
authors.lastname: van Erkel
authors.forename: P D S
authors.initials: PD
authors.lastname: Dijkstra
mesh_terms: D001843:Bone Cements / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D050815:Fractures, Compression / Q000209:etiology / Q000601:surgery*; D005598:Fractures, Spontaneous / Q000209:etiology / Q000601:surgery*; D006801:Humans; D010024:Osteoporosis / Q000150:complications; D058866:Osteoporotic Fractures / Q000209:etiology / Q000601:surgery*; D010146:Pain / Q000601:surgery; D010147:Pain Measurement; D016103:Spinal Fractures / Q000209:etiology / Q000601:surgery*; D016896:Treatment Outcome; D054854:Vertebroplasty / Q000009:adverse effects / Q000379:methods
chemical_list: D001843:Bone Cements