title: The RNA infrastructure: an introduction to ncRNA networks.
abstract: The RNA infrastructure connects RNA-based functions. With transcription-to-translation processing forming the core of the network, we can visualise how RNA-based regulation, cleavage and modification are the backbone of cellular function. The key to interpreting the RNA-infrastructure is in understanding how core RNAs (tRNA, mRNA and rRNA) and other ncRNAs operate in a spatial-temporal manner, moving around the nucleus, cytoplasm and organelles during processing, or in response to environmental cues. This chapter summarises the concept of the RNA-infrastructure, and highlights examples of RNA-based networking within prokaryotes and eukaryotes. It describes how transcription-to-translation processes are tightly connected, and explores some similarities and differences between prokaryotic and eukaryotic RNA networking.
authors.affiliation: Institute of Fundamental Sciences, Massey University, Palmerston North, New Zealand. l.j.collins@massey.ac.nz
authors.forename: Lesley J
authors.initials: LJ
authors.lastname: Collins
mesh_terms: D000818:Animals; D005057:Eukaryotic Cells / Q000378:metabolism*; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D006801:Humans; D008957:Models, Genetic; D011387:Prokaryotic Cells / Q000378:metabolism*; D014176:Protein Biosynthesis; D012313:RNA / Q000145:classification / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D012313:RNA