title: The effect of a physician-targeted intervention on metoclopramide prescribing practice.
abstract: BACKGROUND
  Metoclopramide use is associated with serious and potentially irreversible neurologic side effects. However, it is often used for questionable or unclear indications in clinical practice.
  
  
  OBJECTIVE
  To (1) determine whether an intervention targeted at the prescribing physician would increase the rate of metoclopramide discontinuation among patients prescribed the medication for questionable or unclear indications; and (2) assess the durability of the discontinuation.
  
  
  METHODS
  A randomized controlled trial.
  
  
  METHODS
  Ambulatory practices of a quaternary care medical center.
  
  
  METHODS
  Ambulatory, electronic medical record-utilizing clinicians of the quaternary medical center.
  
  
  METHODS
  A letter regarding participating clinicians' prescription(s) of metoclopramide for patients with questionable or unclear indications.
  
  
  METHODS
  The rate and the durability of metoclopramide discontinuation.
  
  
  RESULTS
  Fourteen of 31 (45%) patients of intervention group clinicians and 10 of 30 (33%) patients of nonintervention group clinicians had metoclopramide discontinued within 12 weeks, yielding a risk ratio for metoclopramide discontinuation of 1.4 (95% confidence interval [CI] 0.6-3.0) in the intervention versus nonintervention group. Of the 29 patients who had their metoclopramide discontinued during the study, 26 (90%, 95% CI 73%-98%) still had no active metoclopramide prescription in the subsequent 6 months. No adverse events were detected during the follow-up period.
  
  
  CONCLUSIONS
  A physician-targeted intervention letter did not lead to a statistically significantly increased rate of metoclopramide discontinuation among patients who had questionable or unclear indications for the medication. Discontinuation of metoclopramide therapy for questionable or unclear indications was durable in most patients.
authors.affiliation: Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Yu-Xiao
authors.initials: YX
authors.lastname: Yang
authors.forename: Charles E
authors.initials: CE
authors.lastname: Leonard
authors.forename: Cristin
authors.initials: C
authors.lastname: Freeman
authors.forename: Sean
authors.initials: S
authors.lastname: Hennessy