title: Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results.
abstract: The prognosis in advanced-stage ovarian cancer remains poor. Tumor-specific intraoperative fluorescence imaging may improve staging and debulking efforts in cytoreductive surgery and thereby improve prognosis. The overexpression of folate receptor-α (FR-α) in 90-95% of epithelial ovarian cancers prompted the investigation of intraoperative tumor-specific fluorescence imaging in ovarian cancer surgery using an FR-α-targeted fluorescent agent. In patients with ovarian cancer, intraoperative tumor-specific fluorescence imaging with an FR-α-targeted fluorescent agent showcased the potential applications in patients with ovarian cancer for improved intraoperative staging and more radical cytoreductive surgery.
authors.affiliation: Department of Surgery, Division of Surgical Oncology, BioOptical Imaging Center, University of Groningen, Groningen, The Netherlands. g.m.van.dam@umcg.nl
authors.forename: Gooitzen M
authors.initials: GM
authors.lastname: van Dam
authors.forename: George
authors.initials: G
authors.lastname: Themelis
authors.forename: Lucia M A
authors.initials: LM
authors.lastname: Crane
authors.forename: Niels J
authors.initials: NJ
authors.lastname: Harlaar
authors.forename: Rick G
authors.initials: RG
authors.lastname: Pleijhuis
authors.forename: Wendy
authors.initials: W
authors.lastname: Kelder
authors.forename: Athanasios
authors.initials: A
authors.lastname: Sarantopoulos
authors.forename: Johannes S
authors.initials: JS
authors.lastname: de Jong
authors.forename: Henriette J G
authors.initials: HJ
authors.lastname: Arts
authors.forename: Ate G J
authors.initials: AG
authors.lastname: van der Zee
authors.forename: Joost
authors.initials: J
authors.lastname: Bart
authors.forename: Philip S
authors.initials: PS
authors.lastname: Low
authors.forename: Vasilis
authors.initials: V
authors.lastname: Ntziachristos
mesh_terms: D000368:Aged; D003952:Diagnostic Imaging / Q000379:methods*; D005260:Female; D016650:Fluorescein-5-isothiocyanate / Q000737:chemistry; D058975:Folate Receptor 1 / Q000378:metabolism*; D006801:Humans; D008856:Microscopy, Fluorescence / Q000379:methods*; D008875:Middle Aged; D015394:Molecular Structure; D016343:Monitoring, Intraoperative / Q000379:methods*; D010051:Ovarian Neoplasms / Q000473:pathology*
chemical_list: D058975:Folate Receptor 1; D016650:Fluorescein-5-isothiocyanate