title: Liposome-encapsulated neuropeptides for site-specific microinjection.
abstract: This paper describes an experimental approach based on nanotechnology for assessing the chronic actions of short-lived neuropeptides at specific sites of the brain. This methodology combines the advantages of two different techniques: the microinjection of a suspension of peptide-containing liposomes into a specific site of the brain, and the use of liposomes as a local and sustained release nanosystem of the peptide.
authors.affiliation: Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. frezard@icb.ufmg.br
authors.forename: Frédéric
authors.initials: F
authors.lastname: Frézard
authors.forename: Robson A S
authors.initials: RA
authors.lastname: dos Santos
authors.forename: Marco A P
authors.initials: MA
authors.lastname: Fontes
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D008081:Liposomes / Q000737:chemistry*; D008845:Microinjections / Q000379:methods*; D009479:Neuropeptides / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism*; D051381:Rats
chemical_list: D008081:Liposomes; D009479:Neuropeptides