title: Rapidly progressive Alzheimer disease.
abstract: Different rates of progression have been observed among patients with Alzheimer disease. Risk factors that accelerate deterioration have been identified and some are being discussed, such as genetics, comorbidity, and the early appearance of Alzheimer disease motor signs. Progressive forms of Alzheimer disease have been reported with rapid cognitive decline and disease duration of only a few years. This short review aims to provide an overview of the current knowledge of rapidly progressive Alzheimer disease. Furthermore, we suggest that rapid, in this context, should be defined as a Mini-Mental State Examination score decrease of 6 points per year.
authors.affiliation: Dementia Research Unit, Department of Neurology, Georg-August-Universität Göttingen, Göttingen, Germany. christian.schmidt@medizin.uni-goettingen.de
authors.forename: Christian
authors.initials: C
authors.lastname: Schmidt
authors.forename: Martin
authors.initials: M
authors.lastname: Wolff
authors.forename: Michael
authors.initials: M
authors.lastname: Weitz
authors.forename: Thomas
authors.initials: T
authors.lastname: Bartlau
authors.forename: Carsten
authors.initials: C
authors.lastname: Korth
authors.forename: Inga
authors.initials: I
authors.lastname: Zerr
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D002986:Clinical Trials as Topic / Q000379:methods; D018450:Disease Progression; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D012307:Risk Factors; D013997:Time Factors
chemical_list: D005819:Genetic Markers