title: [Efficacy of endoscopic sinus surgery-based on multidisciplinary treatment for chronic rhinosinusitis with asthma].
abstract: OBJECTIVE
  To evaluate the efficacy of endoscopic sinus surgery (ESS)-based on multidisciplinary treatment for patients with chronic rhinosinusitis (CRS) and asthma.
  
  
  METHODS
  The study included 25 CRS patients with asthma who received ESS from September 2006 to March 2009, besides surgery, who also used corticosteroid nasal spray, oral macrolide antibiotics and nasal irrigation perioperatively. Evaluation was performed before ESS, 1 year and 3 years post-ESS. Evaluation index included visual analogue scale (VAS) and endoscopy Lund-Kennedy assessment for CRS, and asthma control test (ACT) and pulmonary function tests for asthma.
  
  
  RESULTS
  Twenty-three (92%) patients were followed up for 12 months. Twelve (48%) of them were followed up for 36 months. CRS efficacy: VAS of general symptom significantly improved after ESS compared to pre-ESS (8.12 ± 0.60, x(-) ± s), after 1 year (3.20 ± 2.19) and 3 year (3.79 ± 2.32) follow up (both P = 0.000). There was no statistic difference between 1 year and 3 year follow up (P = 0.851). Endoscopy Lund-Kennedy score significantly improved in post-ESS after 1 year (4.35 ± 3.21) and 3 year (5.50 ± 2.64) follow up compared to pre-ESS (9.80 ± 2.10, both P = 0.000), and there was no difference between 1 year and 3 year follow up (P = 0.606). Asthma efficacy: ACT pre-ESS, 1 year and 3 year were 21.96 ± 2.16, 23.61 ± 1.94 and 22.33 ± 3.47, without statistic difference (F = 2.871, P = 0.065). Pulmonary function showed no significant change after surgery (Pre-ESS 74.68 ± 11.09, 1 year 73.27 ± 12.27, 3 year 73.50 ± 7.87, F = 0.076, P > 0.05).
  
  
  CONCLUSIONS
  ESS improves CRS with asthma significantly and persistently. Asthma control level, anti-asthma drug dose and pulmonary function remain stable after ESS.
authors.affiliation: Otorhinolaryngology Hospital, First Affiliated Hospital of SUN Yat-sen University, Guangzhou 510080, China.
authors.forename: Feng-hong
authors.initials: FH
authors.lastname: Chen
authors.forename: Rui
authors.initials: R
authors.lastname: Xu
authors.forename: Ke-jun
authors.initials: KJ
authors.lastname: Zuo
authors.forename: Yu-biao
authors.initials: YB
authors.lastname: Guo
authors.forename: Zhi-ping
authors.initials: ZP
authors.lastname: Li
authors.forename: Jian-bo
authors.initials: JB
authors.lastname: Shi
mesh_terms: D000328:Adult; D000368:Aged; D001249:Asthma / Q000150:complications / Q000601:surgery / Q000628:therapy*; D002908:Chronic Disease; D003131:Combined Modality Therapy; D004724:Endoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012220:Rhinitis / Q000150:complications / Q000601:surgery / Q000628:therapy*; D012852:Sinusitis / Q000150:complications / Q000601:surgery / Q000628:therapy*; D016896:Treatment Outcome