title: Persistent infection drives the development of CD8+ T cells specific for late lytic infection antigens in lymphocryptovirus-infected macaques and Epstein-Barr virus-infected humans.
abstract: We examined the CD8(+) T cell repertoire against lytic infection antigens in rhesus macaques persistently infected with the Epstein-Barr virus (EBV)-related lymphocryptovirus (rhLCV). CD8(+) T cells specific for late (L) antigens were detected at rates comparable to those for early antigens and were associated with increasing duration of infection. L antigen-specific CD8(+) T cells were also readily detected in adult, EBV-positive humans. Thus, viral major histocompatibility complex class I (MHCI) immune evasion genes expressed during lytic LCV infection do not prevent L-specific CD8(+) T cell development over time during persistent infection.
authors.affiliation: Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Nina
authors.initials: N
authors.lastname: Orlova
authors.forename: Fred
authors.initials: F
authors.lastname: Wang
authors.forename: Mark H
authors.initials: MH
authors.lastname: Fogg
mesh_terms: D000328:Adult; D000818:Animals; D000956:Antigens, Viral / Q000276:immunology / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology*; D016207:Cytokines / Q000378:metabolism; D020031:Epstein-Barr Virus Infections / Q000276:immunology / Q000378:metabolism / Q000821:virology; D006566:Herpesviridae Infections / Q000276:immunology / Q000378:metabolism / Q000821:virology; D004854:Herpesvirus 4, Human / Q000472:pathogenicity*; D006801:Humans; D057131:Immune Evasion; D018143:Lymphocryptovirus / Q000472:pathogenicity*; D008253:Macaca mulatta / Q000276:immunology / Q000821:virology*; D014412:Tumor Virus Infections / Q000276:immunology / Q000378:metabolism / Q000821:virology; D014779:Virus Replication
chemical_list: D000956:Antigens, Viral; D016207:Cytokines