title: [Surveillance and research on acute meningitis, encephalitis syndrome in Guangxi, China].
abstract: OBJECTIVE
  To estimate disease burden and epidemiological characteristics of acute meningitis/encephalitis, and provide the basis for the disease control strategy development.
  
  
  METHODS
  A syndrome surveillance system was established in Guigang city with a population of 5 020 000. For the suspected cases, serum and CSF were collected, and bacterial culture, latex agglutination test, real-time PCR and ELISA tests were carried out. All involved cases were identified to 6 categories according to WHO case definition.
  
  
  RESULTS
  1424 suspected cases were evaluated in a surveillance of 30 months, yielding the incidence, mortality and mortality of 11.35/100 000 (1424/12 546 500 person years), 0.43/100 000 (54/12 546 500 person years), 3.79% (54/1424) respectively. A total of 103 and 51 cases were confirmed for JE, bacterial meningitis, with a incidence of 0.82/100 000 (103/12 546 500 person years), 0.41/100 000 (51/12 546 500 person years). 96.10% (99/103) of JE cases and 37.30% (19/51) bacterial meningitis cases occurred in < 10 years old children and < 5 years old children. A clinical misdiagnosis rate of 19.42% (20/103) and 15.69% (8/51) were observed for JE and bacterial meningitis.
  
  
  CONCLUSIONS
  Acute encephalitis, meningitis syndrome can cause a higher burden of disease, of which the main components of viral encephalitis. Most of syndrome is occurred in summer and autumn, mainly reported in children of younger than 10 years old. A quite misdiagnosis would be made among meningitis and encephalitis syndrome cases.
authors.affiliation: Health Department of Guangxi Autonomous Region, Department of Disease Control, Nanning 530021, China.
authors.forename: Bai-qing
authors.initials: BQ
authors.lastname: Dong
authors.forename: Jin-ye
authors.initials: JY
authors.lastname: Yang
authors.forename: Mei
authors.initials: M
authors.lastname: Lin
authors.forename: Yi
authors.initials: Y
authors.lastname: Tan
authors.forename: Xing-hua
authors.initials: XH
authors.lastname: Wu
authors.forename: Yi
authors.initials: Y
authors.lastname: Quan
authors.forename: Yi-hong
authors.initials: YH
authors.lastname: Xie
authors.forename: Fu-yin
authors.initials: FY
authors.lastname: Bi
authors.forename: Yi-xing
authors.initials: YX
authors.lastname: Li
authors.forename: Stephen
authors.initials: S
authors.lastname: Hadler
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D018792:Encephalitis, Viral / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D016920:Meningitis, Bacterial / Q000453:epidemiology; D008590:Meningoencephalitis / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control / Q000821:virology; D008875:Middle Aged; D012621:Seasons; D055815:Young Adult