title: Low virulent oral Candida albicans strains isolated from smokers.
abstract: It is widely accepted that tabagism is a predisposing factor to oral candidosis and cumulate data suggest that cigarette compounds may increase candidal virulence. To verify if enhanced virulence occurs in Candida albicans from chronic smokers, a cohort of 42 non-smokers and other of 58 smokers (all with excellent oral conditions and without signs of candidosis) were swabbed on tong dorsum and jugal mucosa. Results showed that oral candidal loads do not differ between smoker and non-smokers. Activities of secreted aspartyl-protease (Sap), phospholipase, chondroitinase, esterase-lipase, and haemolysin secretions were screened for thirty-two C. albicans isolates. There were detected significant increments in phospholipasic and chondroitinasic activities in isolates from non-smokers. For other virulence factors, no differences between both cohorts were achieved.
authors.affiliation: Dental Clinics, General Hospital of Curitiba. Praca Marechal Alberto Ferreira de Abreu, Curitiba, Brazil.
authors.forename: Ana Claudia Santos
authors.initials: AC
authors.lastname: de Azevedo Izidoro
authors.forename: Andressa Marafon
authors.initials: AM
authors.lastname: Semprebom
authors.forename: Fernanda Brasil
authors.initials: FB
authors.lastname: Baboni
authors.forename: Rosimeire Takaki
authors.initials: RT
authors.lastname: Rosa
authors.forename: Maria Angela Naval
authors.initials: MA
authors.lastname: Machado
authors.forename: Lakshman Perera
authors.initials: LP
authors.lastname: Samaranayake
authors.forename: Edvaldo Antonio Ribeiro
authors.initials: EA
authors.lastname: Rosa
mesh_terms: D002176:Candida albicans / Q000201:enzymology / Q000302:isolation & purification / Q000472:pathogenicity*; D002180:Candidiasis, Oral / Q000382:microbiology*; D015331:Cohort Studies; D006460:Hemolysin Proteins / Q000302:isolation & purification*; D006801:Humans; D009061:Mouth Mucosa / Q000382:microbiology*; D012907:Smoking / Q000009:adverse effects*; D014774:Virulence
chemical_list: D006460:Hemolysin Proteins