title: [Characteristics of duodenogastric reflux in duodenal ulcer patients and its dynamics after Helicobacter pylori eradication].
abstract: Studying role of duodenogastric reflux (DGR) in pathogenesis and sanogenesis of duodenal ulcer (DU).
  
  
  METHODS
  233 DU patients (92 patients with a mild, 45--with modern and 96--with the complicated current of disease) are surveyed. Control group were 100 healthy volunteers. Clinical research, endoscopy and 24-hours pH-metria was carried out. In a year after eradication Helicobacter pylori (Hp) 30 patients are repeatedly surveyed.
  
  
  RESULTS
  at healthy acidity more low, and DGR above and more for a long time, than at DU patients. DU was especially supressed at complicated current DU. Eradication Hp was accompanied by acidity normalization only at mild DU, and at complicated DU--is not present.
  
  
  CONCLUSIONS
  at healthy people DGR arises in reply to antrum's acidification and has compensative value, and at DU there is the considerable suppression leading to insufficiency of antrum's alkalization. After eradication Hp normalization DGR is marked only at mild current DU.
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Kolesnikova
authors.forename: V S
authors.initials: VS
authors.lastname: Volkov
authors.forename: L A
authors.initials: LA
authors.lastname: Liubskaia
mesh_terms: D000328:Adult; D000658:Amoxicillin / Q000008:administration & dosage / Q000627:therapeutic use; D017291:Clarithromycin / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004381:Duodenal Ulcer / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism / Q000382:microbiology; D004383:Duodenogastric Reflux / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism / Q000382:microbiology; D005260:Female; D005500:Follow-Up Studies; D005744:Gastric Acid / Q000737:chemistry / Q000378:metabolism; D005745:Gastric Acidity Determination; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D009853:Omeprazole / Q000008:administration & dosage / Q000627:therapeutic use; D012008:Recurrence; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000658:Amoxicillin; D017291:Clarithromycin; D009853:Omeprazole