title: Assessment of corneal dynamics with high-speed swept source optical coherence tomography combined with an air puff system.
abstract: We present a novel method and instrument for in vivo imaging and measurement of the human corneal dynamics during an air puff. The instrument is based on high-speed swept source optical coherence tomography (ssOCT) combined with a custom adapted air puff chamber from a non-contact tonometer, which uses an air stream to deform the cornea in a non-invasive manner. During the short period of time that the deformation takes place, the ssOCT acquires multiple A-scans in time (M-scan) at the center of the air puff, allowing observation of the dynamics of the anterior and posterior corneal surfaces as well as the anterior lens surface. The dynamics of the measurement are driven by the biomechanical properties of the human eye as well as its intraocular pressure. Thus, the analysis of the M-scan may provide useful information about the biomechanical behavior of the anterior segment during the applanation caused by the air puff. An initial set of controlled clinical experiments are shown to comprehend the performance of the instrument and its potential applicability to further understand the eye biomechanics and intraocular pressure measurements. Limitations and possibilities of the new apparatus are discussed.
authors.affiliation: Institute of Physics, Nicolaus Copernicus University, ul. Grudziadzka 5/7, PL-87-100 Torun, Poland.
authors.forename: David
authors.initials: D
authors.lastname: Alonso-Caneiro
authors.forename: Karol
authors.initials: K
authors.lastname: Karnowski
authors.forename: Bartlomiej J
authors.initials: BJ
authors.lastname: Kaluzny
authors.forename: Andrzej
authors.initials: A
authors.lastname: Kowalczyk
authors.forename: Maciej
authors.initials: M
authors.lastname: Wojtkowski
mesh_terms: D000328:Adult; D000388:Air; D000869:Anterior Eye Segment / Q000502:physiology; D003315:Cornea / Q000502:physiology*; D006801:Humans; D007322:Instillation, Drug; D007429:Intraocular Pressure; D011312:Pressure; D013499:Surface Properties; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods*; D014065:Tonometry, Ocular