title: Reproductive tract infections in HIV positive women: A case control study.
abstract: BACKGROUND
  Human immunodeficiency virus (HIV) infection primarily affects women during their reproductive years, and the coexistence of reproductive tract infections (RTIs) is not surprising given the fact that HIV is mainly acquired via heterosexual contact.
  
  
  OBJECTIVE
  The aim of the study was to compare the occurrence of RTIs among infected and noninfected women.
  
  
  METHODS
  A case control study of 83 HIV positive women, tested by two enzyme linked immunosorbent assay (ELISA) and a matched control of 87 HIV negative women were screened for RTIs. They were submitted to gynecological examination and cervical cytology.
  
  
  RESULTS
  The mean age for HIV positive women was 30 years and that for HIV negative women was 27 years. 18% HIV positive women had menstrual irregularities compared to 6% in seronegative group (P= 0.024). Vaginal infections including sexually transmitted infections (STIs) were found in 47 (57%) HIV positive women and 30 (34%) HIV negative women (P= 0.0037). Vaginal candidiasis was the most common infection (34%) in HIV positive women, followed by trichomoniasis (12%). Human papilloma virus (HPV) infection was seen in nine HIV positive women versus none in HIV negative women. Cervical cytology showed inflammation in 53 (64%) HIV positive women compared to 27 (31%) HIV negative women (P= 0.000023). Genital neoplasia, including carcinoma in situ was observed in 2 (2.5%) HIV positive women and in none of the HIV negative women.
  
  
  CONCLUSIONS
  It is seen that reproductive tract morbidities are common in HIV positive women. So it is imperative that HIV positive women have a complete gynecological evaluation including a Papanicolaou (PAP) smear with aggressive screening of STIs.
authors.affiliation: Department of Skin and VD, Medical College and SSG Hospital, Vadodara, India.
authors.forename: Archana
authors.initials: A
authors.lastname: Sharma
authors.forename: Y S
authors.initials: YS
authors.lastname: Marfatia
authors.forename: Megha
authors.initials: M
authors.lastname: Modi