title: Hepatocellular carcinoma presenting as polymyositis: a paraneoplastic syndrome.
abstract: Polymyositis as a paraneoplastic syndrome associated with hepatocellular carcinoma is quite rare; only a few cases have been reported. We report a case of a 50-year-old female who presented with subacute quadriparesis, neck muscle weakness, elevated creatinine phosphokinase, a myogenic pattern on the EMG and was diagnosed as having polymyositis, a paraneoplastic syndrome associated with hepatocellular carcinoma with negative hepatic viral markers and a positive ANA. Improvement in patient symptoms and areduction in creatinine phosphokinase, which occurred after lobectomy, supports this rare association.
authors.affiliation: Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India. dhirajk-ishore@gmail.com
authors.forename: Dhiraj
authors.initials: D
authors.lastname: Kishore
authors.forename: Vishal
authors.initials: V
authors.lastname: Khurana
authors.forename: Amit
authors.initials: A
authors.lastname: Raj
authors.forename: Indarajeet Singh
authors.initials: IS
authors.lastname: Gambhir
authors.forename: Amita
authors.initials: A
authors.lastname: Diwaker
mesh_terms: D000974:Antibodies, Antinuclear / Q000276:immunology; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003402:Creatine Kinase / Q000378:metabolism; D004576:Electromyography; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D017285:Polymyositis / Q000175:diagnosis* / Q000473:pathology; D011782:Quadriplegia / Q000209:etiology
chemical_list: D000974:Antibodies, Antinuclear; D003402:Creatine Kinase