title: Tissue and serum adiponectin levels in patients with gastric cancer: are there any correlations between adiponectin levels and histopathological variables?
abstract: OBJECTIVE
  Adiponectin is secreted from adipose tissue and is characterized by hyperinsulinemia, which is related with obesity. Adiponectin levels are significantly lower in gastric cancer patients than in healthy controls. The aim of this study was to investigate the relationship between adiponectin levels in serum, tumor tissue and normal tissue with some other insulin resistance parameters.
  
  
  METHODS
  A total of 35 patients with gastric cancer who had undergone curative gastrectomy by standard lymph node dissection were enrolled in this study. Their serum adiponectin levels, tumor tissue and normal breast tissue adiponectin levels were compared.
  
  
  RESULTS
  The mean adiponectin levels of the tumor tissue, normal gastric tissue and serum were 48.6±2.9 (range, 39.7-50.6), 48.3±4.2 (range, 34.4-50.69) and 49.4±0.83 (range, 48.2-50.2), respectively. There was no relationship between the adiponectin levels in serum, normal tissue and tumor tissue (p=0.08). There was an inverse relationship between normal tissue adiponectin levels and insulin levels (p=0.002, r=-0.5), but this association was not detected with adiponectin levels in tumor and serum (p>0.05).
  
  
  CONCLUSIONS
  Relationships between adiponectin levels in serum, normal tissue and tumor tissue for gastric cancer patients were not found. The small sample size in this study may have influenced the results. However, we believe that our results constitute a first in evaluating the tissue adiponectin levels in gastric cancer tissue.
authors.affiliation: Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, Istanbul, Turkey. drmesutseker@gmail.com
authors.forename: Mesut
authors.initials: M
authors.lastname: Seker
authors.forename: Ahmet
authors.initials: A
authors.lastname: Bilici
authors.forename: Derya Oztas
authors.initials: DO
authors.lastname: Guler
authors.forename: Bala Basak
authors.initials: BB
authors.lastname: Ustaalioglu
authors.forename: Hülya
authors.initials: H
authors.lastname: Gozu
authors.forename: Fatih Yavuz
authors.initials: FY
authors.lastname: Erkal
authors.forename: Berkant
authors.initials: B
authors.lastname: Sonmez
authors.forename: Mehmet
authors.initials: M
authors.lastname: Karaduman
authors.forename: Umut
authors.initials: U
authors.lastname: Kefeli
authors.forename: Emre
authors.initials: E
authors.lastname: Yildirim
authors.forename: Taflan
authors.initials: T
authors.lastname: Salepci
authors.forename: Mahmut
authors.initials: M
authors.lastname: Gumus
mesh_terms: D052242:Adiponectin / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery
chemical_list: D052242:Adiponectin; D014408:Biomarkers, Tumor