title: Lessons learned from clinical trials in acute heart failure: phase 3 drug trials.
abstract: Phase 3 clinical trials in acute heart failure are conducted to allow safety and efficacy data to be collected for the evaluation of treatment strategies, including drugs, devices, diagnostics, or nonpharmacological interventions. There are several important features regarding the conduct of phase 3 clinical trials in acute heart failure. This article describes in detail these important aspects of conducting phase 3 clinical trials in an acute heart failure population.
authors.affiliation: Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA. oconn002@mc.duke.edu
authors.forename: Christopher M
authors.initials: CM
authors.lastname: O'Connor
authors.forename: Mona
authors.initials: M
authors.lastname: Fiuzat
mesh_terms: D000208:Acute Disease; D058406:Cardiac Resynchronization Therapy / Q000379:methods*; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D017326:Clinical Trials, Phase III as Topic; D006333:Heart Failure / Q000628:therapy*; D006801:Humans; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D013577:Syndrome
chemical_list: D002317:Cardiovascular Agents