title: Diarylpropanes and an arylpropyl quinone from Combretum griffithii.
abstract: Three new diarylpropanes (1-3), a new arylpropyl quinone (4), and the known 1-(2-hydroxy-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)propane (5) were isolated from a methanol extract of stems of Combretum griffithii. Their structures were elucidated by spectroscopic methods. Compounds 1, 2, 4, and 5 showed cytotoxicity against one or more cancer cell lines (KB, MCF7, and NCI-H187), and compound 5 exhibited activity against Mycobacterium tuberculosis (MIC 3.13 μg/mL).
authors.affiliation: Natural Products Research Unit, Department of Chemistry, Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand. mpanaw@kku.ac.th
authors.forename: Panawan
authors.initials: P
authors.lastname: Moosophon
authors.forename: Somdej
authors.initials: S
authors.lastname: Kanokmedhakul
authors.forename: Kwanjai
authors.initials: K
authors.lastname: Kanokmedhakul
mesh_terms: D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029765:Combretum / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007624:KB Cells; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis; D019906:Nuclear Magnetic Resonance, Biomolecular; D018547:Plant Stems / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D011407:Propane / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013785:Thailand
chemical_list: D000962:Antimalarials; D011809:Quinones; D011407:Propane