title: Weight evolution and perceptions of adults living with HIV following initiation of antiretroviral therapy in a South African urban setting.
abstract: BACKGROUND
  Obesity and undernutrition are common in South Africa and influence the health outcomes of people living with the human immunodeficiency virus (PLHIV).
  
  
  OBJECTIVE
  To describe the anthropometric changes and perceptions of body weight in adults initiated on antiretroviral therapy (ART).
  
  
  METHODS
  A cohort of 230 PLHIV was enrolled at an HIV clinic in Durban. Changes in their body mass index, and waist and hip girth were measured 6-monthly in the 12 months following initiation of ART. Data on demographic and socio-economic variables, CD4 counts, opportunistic infections and drug regimens used were recorded. Perceptions of body weight and desire to change these were ascertained.
  
  
  RESULTS
  Weight perceptions of respondents were incongruent with their body mass index, with the trend being to judge themselves as weighing less than their actual weight. Those wanting to gain weight gained an average of 7.8 kg - 2.8 times more than those satisfied with their weight (p<0.001). After 12 months on ART, there was a statistically significant increase in anthropometric measurements (p<0.001) with 43 of the 110 women having waist circumferences that increased their risk of cardiovascular disease; the incidence of lipodystrophy was 35% (62/177) (95% confidence interval 27-42%), 36% (64/177) were overweight and 22% (39/177) were obese, compared with 21% (49.230) and 12% (28/230) respectively at baseline (p=0.002).
  
  
  CONCLUSIONS
  There is a strong association between PLHIV's perception of body weight, their desire to gain weight and their actual weight gain on ART. Lipodystrophy, weight gain and truncal obesity are common among PLHIV after initiating ART.
authors.affiliation: Department of FAmily Medicine, University of KwaZulu-Natal, Durban.
authors.forename: E
authors.initials: E
authors.lastname: Hurley
authors.forename: A
authors.initials: A
authors.lastname: Coutsoudis
authors.forename: J
authors.initials: J
authors.lastname: Giddy
authors.forename: S E
authors.initials: SE
authors.lastname: Knight
authors.forename: E
authors.initials: E
authors.lastname: Loots
authors.forename: T M
authors.initials: TM
authors.lastname: Esterhuizen
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D015992:Body Mass Index; D001835:Body Weight; D015897:Comorbidity; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008060:Lipodystrophy / Q000453:epidemiology; D008297:Male; D044342:Malnutrition / Q000453:epidemiology; D009765:Obesity / Q000453:epidemiology; D013019:South Africa; D055105:Waist Circumference; D049629:Waist-Hip Ratio; D015430:Weight Gain
chemical_list: D044966:Anti-Retroviral Agents