title: Catatonia as a manifestation of tacrolimus-induced neurotoxicity in organ transplant patients: a case series.
abstract: Tacrolimus has been associated with severe neurotoxicity in organ transplant patients. Catatonia can be a rare manifestation of tacrolimus-induced neurotoxicity as we report two cases of catatonia in solid organ transplant patients on tacrolimus. Catatonic symptoms completely resolved in these patients after reducing the tacrolimus dosage or switching it to alternative immunosuppressants. Catatonia symptoms in organ transplant patients should alert clinicians to look for tacrolimus-induced neurotoxicity despite normal serum tacrolimus levels and neuroimaging findings.
authors.affiliation: Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA. chopra.amit@mayo.edu
authors.forename: Amit
authors.initials: A
authors.lastname: Chopra
authors.forename: Piyush
authors.initials: P
authors.lastname: Das
authors.forename: Abhishek
authors.initials: A
authors.lastname: Rai
authors.forename: Preetha Sharone
authors.initials: PS
authors.lastname: Kuppuswamy
authors.forename: Xiofan
authors.initials: X
authors.lastname: Li
authors.forename: John
authors.initials: J
authors.lastname: Huston
authors.forename: Kemuel
authors.initials: K
authors.lastname: Philbrick
authors.forename: Christopher
authors.initials: C
authors.lastname: Sola
mesh_terms: D002389:Catatonia / Q000209:etiology*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D020258:Neurotoxicity Syndromes / Q000150:complications* / Q000209:etiology*; D016377:Organ Transplantation; D016559:Tacrolimus / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus