title: Synthesis, iron(III)-binding affinity and in vitro evaluation of 3-hydroxypyridin-4-one hexadentate ligands as potential antimicrobial agents.
abstract: Iron is a critical element for the survival of bacteria. We have designed and synthesized two novel 3-hydroxypyridin-4-one hexadentate ligands with high affinity for iron(III), which disrupt bacterial iron absorption. Biological studies demonstrate that these two chelators have significant inhibitory effect against both Gram-positive and Gram-negative bacteria, and therefore have potential as antimicrobial agents.
authors.affiliation: School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, Zhejiang 310012, PR China.
authors.forename: Bo
authors.initials: B
authors.lastname: Xu
authors.forename: Xiao-Le
authors.initials: XL
authors.lastname: Kong
authors.forename: Tao
authors.initials: T
authors.lastname: Zhou
authors.forename: Di-Hong
authors.initials: DH
authors.lastname: Qiu
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Chen
authors.forename: Mu-Song
authors.initials: MS
authors.lastname: Liu
authors.forename: Rong-Hua
authors.initials: RH
authors.lastname: Yang
authors.forename: Robert C
authors.initials: RC
authors.lastname: Hider
mesh_terms: D000900:Anti-Bacterial Agents / Q000378:metabolism* / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D066298:In Vitro Techniques; D007501:Iron / Q000378:metabolism*; D008024:Ligands; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D056004:Molecular Dynamics Simulation; D011725:Pyridines / Q000378:metabolism* / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000900:Anti-Bacterial Agents; D008024:Ligands; D011725:Pyridines; C506370:hexadentate 3-hydroxypyridin-4-one; D007501:Iron