title: Shedding light by cancer redox-human NAD(P)H:quinone oxidoreductase 1 activation of a cloaked fluorescent dye.
abstract: A new quinone propionic acid-cloaked rhodamine fluorophore has its fluorescence revealed (de-cloaked) upon activation by human NAD(P)H:quinone oxidoreductase 1 (hNQO1), an upregulated enzyme in cancer cells and tumors.
authors.affiliation: Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803-1804, USA.
authors.forename: William C
authors.initials: WC
authors.lastname: Silvers
authors.forename: Alex S
authors.initials: AS
authors.lastname: Payne
authors.forename: Robin L
authors.initials: RL
authors.lastname: McCarley
mesh_terms: D045744:Cell Line, Tumor; D004789:Enzyme Activation; D057075:Enzyme Assays / Q000379:methods*; D005456:Fluorescent Dyes / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D009025:Morpholines / Q000737:chemistry; D010084:Oxidation-Reduction; D011808:Quinone Reductases / Q000378:metabolism*; D013050:Spectrometry, Fluorescence
chemical_list: D005456:Fluorescent Dyes; D009025:Morpholines; C037574:morpholine; C041831:NADH dehydrogenase (quinone); D011808:Quinone Reductases