title: Brain metastases from colorectal carcinoma: a description of 60 cases in a single Chinese cancer center.
abstract: The incidence of brain metastasis (BM) from colorectal carcinoma (CRC) is increasing. The objectives of the present study were to explore the clinical characteristics and potential prognostic factors in CRC patients with BM. Between April 1991 and December 2010, all CRC patients treated in the Sun Yat-sen University Cancer Center were retrospectively reviewed and 60 patients were identified to have BM (36 males and 24 females). The association between patients and their tumor characteristics, treatment modality, and survival were statistically analyzed. The median age at diagnosis of BM was 62.5 years. Fifty-three patients (88.3%) developed extracranial metastases at diagnosis of BM. The cause of death was systemic disease in 19 patients and neurological disease in 23 patients. Brain metastases were primarily treated with either whole brain radiation therapy (WBRT; 15 patients), stereotactic radiosurgery (SRS; nine patients), or surgical resection (seven patients). Ten patients received WBRT and SRS, and 19 patients (31.7%) were treated with steroids alone. The median survival after diagnosis of BM was 8 months (95% confidence interval = 4.2-11.8 months). Recursive partitioning analysis (RPA) class, the number of brain lesions, and treatment modality type were significantly associated with survival. Although BM from CRC is a late-stage phenomenon with an extremely poor prognosis, some subsets of patients would benefit from a multidisciplinary management strategy. A low RPA class and a limited number of brain lesions may predict increased survival after therapy for CRC patients with BM.
authors.affiliation: Department of Neurosurgery, Sun Yat-sen University Cancer Center, No. 651, Dong Feng Road E., Guangzhou, 510060, People's Republic of China.
authors.forename: Xiao-Bing
authors.initials: XB
authors.lastname: Jiang
authors.forename: Qun-Ying
authors.initials: QY
authors.lastname: Yang
authors.forename: Ke
authors.initials: K
authors.lastname: Sai
authors.forename: Xiang-Heng
authors.initials: XH
authors.lastname: Zhang
authors.forename: Zhong-Ping
authors.initials: ZP
authors.lastname: Chen
authors.forename: Yong-Gao
authors.initials: YG
authors.lastname: Mou
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D001921:Brain / Q000473:pathology / Q000528:radiation effects / Q000601:surgery; D001932:Brain Neoplasms / Q000208:ethnology / Q000556:secondary* / Q000628:therapy*; D002423:Cause of Death; D002681:China; D015179:Colorectal Neoplasms / Q000208:ethnology / Q000401:mortality / Q000473:pathology*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016634:Radiosurgery / Q000379:methods; D011878:Radiotherapy / Q000379:methods; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult