title: Dilated cardiomyopathy and inclusion body myositis.
abstract: Inclusion body myositis (IBM) is the most common inflammatory myopathy after 50 years of age. In contrast to polymyositis and dermatomyositis, in which cardiac involvement is relatively common, current evidences indicate that IBM is not associated with cardiac disease. We report the case of a patient with biopsy-proven IBM who developed heart failure and major ventricular arrhythmias secondary to dilated cardiomyopathy few months after the clinical onset of IBM, and in whom no pathophysiologic causes explaining cardiac enlargement and dysfunction were found by laboratory and instrumental investigations. The hypothesis of a pathophysiologic association between the two conditions is discussed.
authors.affiliation: Cardiology Unit, S. Maria Annunziata Hospital, Local Health Unit, via dell'Antella 58, Florence, Italy. pcballo@tin.it
authors.forename: Piercarlo
authors.initials: P
authors.lastname: Ballo
authors.forename: Leandro
authors.initials: L
authors.lastname: Chiodi
authors.forename: Matteo
authors.initials: M
authors.lastname: Cameli
authors.forename: Alessandro
authors.initials: A
authors.lastname: Malandrini
authors.forename: Antonio
authors.initials: A
authors.lastname: Federico
authors.forename: Sergio
authors.initials: S
authors.lastname: Mondillo
authors.forename: Alfredo
authors.initials: A
authors.lastname: Zuppiroli
mesh_terms: D000368:Aged; D001706:Biopsy / Q000379:methods; D002311:Cardiomyopathy, Dilated / Q000175:diagnosis / Q000209:etiology*; D004452:Echocardiography; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology; D018979:Myositis, Inclusion Body / Q000150:complications*; D016900:Neurofilament Proteins / Q000378:metabolism
chemical_list: D016900:Neurofilament Proteins