title: Assessment of depression and anxiety in haematological cancer patients and their relationship with quality of life.
abstract: OBJECTIVE
  To determine the relationship between major depressive disorder, anxiety disorders and the quality of life of haematological cancer patients.
  
  
  METHODS
  This cross-sectional study was conducted at Ampang Hospital Kuala Lumpur, Malaysia, a tertiary referral centre hospital for haematological cancer. The Mini-International Neuropsychiatric Interview was used for the diagnosis of major depressive disorder and anxiety disorders. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire was utilised to measure patients' quality of life.
  
  
  RESULTS
  A total of 105 haematological cancer patients were included in the study with response rate of 100%. Major depressive disorder correlated with almost all domains of the quality of life, except the pain scores. Logistic regression showed that insomnia and financial difficulties were related to major depressive disorder. Different anxiety disorders also correlated with quality of life in specific domains. The leading anxiety disorders that correlated mostly with quality-of-life scales were generalised anxiety disorder, followed by obsessive-compulsive disorder, social anxiety disorder, as well as post-traumatic stress disorder and panic disorder with agoraphobia (p<0.05).
  
  
  CONCLUSIONS
  Psychological treatment along with medication and intervention should be implemented to improve the overall quality of life and psychiatric disorder symptoms among the haematological cancer patients.
authors.affiliation: Department of Community Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia. daspriscilla@yahoo.com
authors.forename: Das
authors.initials: D
authors.lastname: Priscilla
authors.forename: Awang
authors.initials: A
authors.lastname: Hamidin
authors.forename: M Zain
authors.initials: MZ
authors.lastname: Azhar
authors.forename: Khin Ohnmar Naing
authors.initials: KO
authors.lastname: Noorjan
authors.forename: M Said
authors.initials: MS
authors.lastname: Salmiah
authors.forename: Khalid
authors.initials: K
authors.lastname: Bahariah
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001008:Anxiety Disorders / Q000453:epidemiology* / Q000523:psychology*; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003865:Major Depressive Disorder / Q000453:epidemiology* / Q000523:psychology*; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications / Q000523:psychology*; D006801:Humans; D008296:Malaysia / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life / Q000523:psychology*