title: Effect of different doses of GLP-2 (Teduglutide) on acute esophageal lesion due to acid-pepsin perfusion in male rats.
abstract: Gastro-esophageal reflux currently is widespread disorders with dangerous complications. GLP-2 is a peptide that has trophic and anti-inflammatory effects on gastrointestinal mucosa. The aim of this study was to evaluate the protective role of GLP-2 in esophageal mucosa lesion due to perfusion acid-pepsin. Thirty-six male rats were used in this study and divided into six groups. They were control, acid-pepsin, GLP-2 20 μg, GLP-2 30 μg, GLP-2 40 μg and GLP-2 50 μg/kg groups. Esophageal blood flow, plasma NO metabolite, esophageal tissue NO metabolites and histological study of esophagus were performed as indicators of esophageal damage following acid-pepsin perfusion. Results showed that GLP-2 significantly increased plasma and tissue NO metabolites in comparison to acid-pepsin group. Also histological study showed significantly fewer lesions in the most effective dose GLP-2 30 μg in comparison to acid-pepsin group, our results show that GLP-2 could be useful for the treatment of esophageal in animal model.
authors.affiliation: Department of Physiology, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Rohallah
authors.initials: R
authors.lastname: Moloudi
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Nabavizadeh
authors.forename: Hossein
authors.initials: H
authors.lastname: Nahrevanian
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Hassanzadeh
mesh_terms: D000818:Animals; D004947:Esophagus / Q000187:drug effects* / Q000473:pathology*; D006801:Humans; D006851:Hydrochloric Acid / Q000494:pharmacology; D008297:Male; D009092:Mucous Membrane / Q000187:drug effects* / Q000473:pathology*; D009569:Nitric Oxide / Q000378:metabolism; D010434:Pepsin A / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010455:Peptides; D009569:Nitric Oxide; C494910:teduglutide; D010434:Pepsin A; D006851:Hydrochloric Acid