title: Is γ-glutamyl transferase activity a potential marker of left ventricular function during early postmyocardial infarction period?
abstract: OBJECTIVE
  γ-glutamyl transferase (GGT) is an independent prognostic marker for cardiac death and reinfarction in patients with coronary artery disease, but its clinical significance during early postmyocardial infarction period is unclear.
  
  
  METHODS
  This short-term prospective study included 40 patients with acute myocardial infarction (AMI) in whom we determined GGT activity, lipids, uric acid, homocysteine (Hcy), high sensitivity C-reactive protein (hsCRP) and left ventricular (LV) function on admission and on day 5 following AMI.
  
  
  RESULTS
  In AMI patients on admission, logGGT was associated with logHcy (r = 0.36), uric acid (r = 0.48) and CK-MB activity (r = -0.41). Uric acid remained an independent determinant of serum GGT activity on admission. Significant increase in GGT activity (77.7%) was observed following AMI. On day 5 serum logGGT was significantly associated with LV relative wall thickness (r = -0.37), LV end-diastolic diameter (r = 0.41) and LV fractional shortening (r = -0.36). In addition, a significant positive correlation was found between serum logGGT and loghsCRP (r = 0.41) and logHcy values (r = 0.395), but only LV end-diastolic diameter remained independently associated with serum GGT activity on day 5 following AMI.
  
  
  CONCLUSIONS
  GGT is associated with oxidative/inflammatory markers and LV diastolic diameter suggesting its potential role in predicting LV dilatation and dysfunction during the early postmyocardial infarction period.
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Sarajevo, Cekaluša 90, 71 000 Sarajevo, Bosnia & Herzegovina. amina.valjevac@mf.unsa.ba
authors.forename: Amina
authors.initials: A
authors.lastname: Valjevac
authors.forename: Alen
authors.initials: A
authors.lastname: Dzubur
authors.forename: Emina
authors.initials: E
authors.lastname: Nakas-Icindic
authors.forename: Almira
authors.initials: A
authors.lastname: Hadzovic-Dzuvo
authors.forename: Orhan
authors.initials: O
authors.lastname: Lepara
authors.forename: Emina
authors.initials: E
authors.lastname: Kiseljakovic
authors.forename: Radivoj
authors.initials: R
authors.lastname: Jadric
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000032:analysis; D003124:Colorimetry; D052279:Creatine Kinase, MB Form / Q000378:metabolism; D004108:Dilatation, Pathologic; D005260:Female; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology* / Q000503:physiopathology*; D018384:Oxidative Stress / Q000502:physiology; D011379:Prognosis; D011446:Prospective Studies; D014527:Uric Acid / Q000097:blood; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology*; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
chemical_list: D014527:Uric Acid; D002097:C-Reactive Protein; D005723:gamma-Glutamyltransferase; D052279:Creatine Kinase, MB Form