title: A novel hydrogen bonded bimetallic supramolecular coordination polymer {[SnMe3(bpe)][Ag(CN)2] · 2H2O} as anticancer drug.
abstract: The reaction of Me(3)SnCl, K(3)[Ag(CN)(4)] and 1,2-bis(4-pyridyl)ethane (bpe) in water/CH(3)CN solution at room temperature affords the novel bimetallic supramolecular coordination polymer (SCP) {[SnMe(3)(bpe)] [Ag(CN)2] · 2H(2)O}(n), 1. The structure of 1 consists of cationic {-Sn(Me(3))-bpe-}(+) chains that are neutralized by [Ag(CN)(2)](-) anions. The dicyanoargentate(I) anions present discrete uncoordinated fragments between the cationic chains. The water molecules bind the cationic chains and the anions forming 3D-supramolecular structure through hydrogen bonds. 1 exhibits strong fluorescence in the solid state at room temperature. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to determine the in vitro antitumor effects of the SCP 1 on human breast cancer cell line, T-47D. Cell cycle analysis revealed that the SCP 1 induced apoptosis in T-47D breast cancer cell line. Moreover, in vivo, the SCP 1 showed tumor growth inhibition in rat model that developed mammary carcinoma by 44.8% compared to the vehicle treated control. Thus, the SCP 1 exhibits specific in vivo and in vitro antitumor effects.
authors.affiliation: Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt. safaaetaiw@hotmail.com
authors.forename: Safaa El-Din H
authors.initials: Sel-D
authors.lastname: Etaiw
authors.forename: Ahmed S
authors.initials: AS
authors.lastname: Sultan
authors.forename: Ahmed S
authors.initials: AS
authors.lastname: Badr El-Din
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D005260:Female; D006801:Humans; D006860:Hydrogen Bonding; D008958:Models, Molecular; D008968:Molecular Conformation; D009947:Organotin Compounds / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D013696:Temperature; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D009947:Organotin Compounds; D011108:Polymers