title: Intramolecular C-H···O hydrogen bonding in 1,4-dihydropyridine derivatives.
abstract: The diastereotopy of the methylene protons at positions 2 and 6 in 1,4-dihydropiridine derivatives with various substituents has been investigated. NMR spectroscopy and quantum chemistry calculations show that the CH···O intramolecular hydrogen bond is one of the factors amplifying the chemical shift differences in the 1H-NMR spectra.
authors.affiliation: Latvian Institute of Organic Synthesis Aizkraukles 21 Street, Riga LV-1006, Latvia. marina@osi.lv
authors.forename: Marina
authors.initials: M
authors.lastname: Petrova
authors.forename: Ruslan
authors.initials: R
authors.lastname: Muhamadejev
authors.forename: Brigita
authors.initials: B
authors.lastname: Vigante
authors.forename: Brigita
authors.initials: B
authors.lastname: Cekavicus
authors.forename: Aiva
authors.initials: A
authors.lastname: Plotniece
authors.forename: Gunars
authors.initials: G
authors.lastname: Duburs
authors.forename: Edvards
authors.initials: E
authors.lastname: Liepinsh
mesh_terms: D004095:Dihydropyridines / Q000138:chemical synthesis / Q000737:chemistry*; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D013329:Structure-Activity Relationship
chemical_list: D004095:Dihydropyridines; C038806:1,4-dihydropyridine