title: Phthalide derivatives with antifungal activities against the plant pathogens isolated from the liquid culture of Pestalotiopsis photiniae.
abstract: Three new phthalide derivatives (1-3) named 5-(3'-methyl-2'-butenyl)-2-hydroxy-3-methoxy-4-methylbenzoic acid (1), 5-(3'-carboxyl-3'-methyl-2E-allyloxy)-3-methoxy-4-methylphthalide (2) and 5-(3',3'-dimethylallyloxy)-2-methoxycarbonyl-3-methoxy-4-methylbenzoic acid (3) together with six known phthalide derivatives named 5-(3',3'-dimethylallyloxy)-3-methoxy-4-methylphthalide (4), zinnimidine (5), 5-(3',3'-dimethylallyloxy)-3-methoxy-4-methylphthalide (6), 5-(3',3'-dimethylallyloxy)-3-methoxy-4-methylphthalic acid (7), zinniol anhydride (8) and porriolide (9) were isolated from the liquid culture of the plant endophytic fungus Pestalotiopsis photiniae isolated from the Chinese Podocarpaceae plant Podocarpus macrophyllus. Their structures were elucidated by extensive spectroscopic analysis. Compounds 1-9 displayed significant antifungal activities against three plant pathogens.
authors.affiliation: Key Laboratory of Pharmaceutical Chemistry and Molecular Diagnosis of Ministry of Education and College of Life Science, Hebei University, Baoding, PR China.
authors.forename: Xiao-Long
authors.initials: XL
authors.lastname: Yang
authors.forename: Su
authors.initials: S
authors.lastname: Zhang
authors.forename: Qiong-Bo
authors.initials: QB
authors.lastname: Hu
authors.forename: Du-Qiang
authors.initials: DQ
authors.lastname: Luo
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D003470:Culture Media / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D013057:Spectrum Analysis; D064028:Tracheophyta / Q000382:microbiology; D013098:Xylariales / Q000254:growth & development / Q000302:isolation & purification / Q000378:metabolism*
chemical_list: D000935:Antifungal Agents; D001572:Benzofurans; D003470:Culture Media; C082022:phthalide