title: Carbapenem-hydrolyzing class D β-lactamase OXA-48 in Klebsiella pneumoniae isolates from Tunisia.
abstract: Two carbapenem-resistant Klebsiella pneumoniae isolates producing the plasmid-encoded carbapenem-hydrolyzing OXA-48 were identified. These isolates, recovered from two patients hospitalized in two different hospitals in Tunisia in December 2010, were not clonally related. Molecular investigations showed that both isolates co-produced the narrow-spectrum β-lactamases TEM-1 and SHV-1, together with the extended-spectrum β-lactamase CTX--15.
authors.affiliation: Service de Bactériologie-Virologie, INSERM U914, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine et Université Paris Sud, K.-Bicêtre, France.
authors.forename: H
authors.initials: H
authors.lastname: Lahlaoui
authors.forename: L
authors.initials: L
authors.lastname: Poirel
authors.forename: F
authors.initials: F
authors.lastname: Barguellil
authors.forename: M B
authors.initials: MB
authors.lastname: Moussa
authors.forename: P
authors.initials: P
authors.lastname: Nordmann
mesh_terms: D000900:Anti-Bacterial Agents / Q000378:metabolism*; D015780:Carbapenems / Q000378:metabolism*; D006801:Humans; D007710:Klebsiella Infections / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D010957:Plasmids; D014416:Tunisia; D014556:Urine / Q000382:microbiology; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; C473109:beta-lactamase CTX-M-15; C054882:beta-lactamase PIT-2; D001618:beta-Lactamases; C034413:beta-lactamase TEM-1; C108449:oxacillinase