title: The PK/PD index (CMAX/MIC) for ciprofloxacin in patients with cystic fibrosis.
abstract: In order to evaluate the efficacy of an antibacterial therapy, three basic PK/PD indexes were defined: the ratio between the maximum drug concentration obtained after a single dose and minimum inhibitory concentration MIC (CMAX/MIC), the ratio between the area under the curve of dependence between the drug concentration in blood and time within 24 hours to MIC (AUC24/MIC), and the time when the concentration of the drug in blood is higher than MIC (T > MIC). The aim of the study was an analysis of the pharmacokinetics of ciprofloxacin and the PK/PD: CMAX/MIC index in patients with cystic fibrosis. Six patients with cystic fibrosis, with the identified microbiological factor were subjected to the examination. The patients received ciprofloxacin in the dose of 400 mg/12 h (i.v.). Plasma drug concentration was measured by HPLC-UV method after the first dose (Cmax1) and at steady state (Cssmax, Cssmin). The following mean values of ciprofloxacin blood concentrations were obtained from the analyzed patients: Cmax1 = 2.34 (+/- 1.15) microg/mL, Cssmax = 2.49 (+/- 1.44) pg/mL, Cssmin = 0.42 (+/- 0.22) pg/mL. The mean values of the Cmax1/MIC and Cssmax/MIC indexes were 3.66 +/- 2.34) and 3.38 (+/-1.73), respectively. Low values of the Cmax/MIC index for ciprofloxacin in the analyzed patients may indicate too low concentrations of the drug in the blood in relation to the MIC value of pathogens and the need to verify the assumed administration scheme.
authors.affiliation: Department of Clinical Pharmacy and Biopharmacy, Karol Marcinkowski University of Medical Sciences, 61-861 Poznań, 14 Sw. Marii Magdaleny St., Poland. czechow73@wp.pl
authors.forename: Edyta
authors.initials: E
authors.lastname: Szałek
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Kamińska
authors.forename: Joanna
authors.initials: J
authors.lastname: Gozdzik-Spychalska
authors.forename: Edmund
authors.initials: E
authors.lastname: Grześkowiak
authors.forename: Halina
authors.initials: H
authors.lastname: Batura-Gabryel
mesh_terms: D000328:Adult; D000465:Algorithms; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics* / Q000494:pharmacology*; D019540:Area Under Curve; D001419:Bacteria / Q000187:drug effects; D002939:Ciprofloxacin / Q000493:pharmacokinetics* / Q000494:pharmacology*; D003550:Cystic Fibrosis / Q000378:metabolism*; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008826:Microbial Sensitivity Tests; D015233:Models, Statistical; D015610:Serum Bactericidal Test; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin