title: A common variation within the STEAP4 gene exons is associated with obesity in Uygur general population.
abstract: BACKGROUND
  Coordinated regulation of nutrient and inflammatory responses by six transmembrane epithelial antigen of prostate 4 (STEAP4) was essential for metabolic homeostasis. STEAP4 expression in human white adipose tissue was associated with obesity. This study aimed to evaluate association between STEAP4 genetic polymorphisms and obesity in Uygur Chinese general population.
  
  
  METHODS
  The functional regions of STEAP4 gene were sequenced in 96 Uygur with obesity (body mass index (BMI) > 30 kg/m²). Representative variations were selected according to the function and linkage disequilibrium and genotyped in 1507 obesity (BMI ≥ 25 kg/m²) and 825 non-obesity control (BMI < 25 kg/m²), all of whom were selected from epidemiology study of obesity-related diseases during January to February 2007 among Uygur population in Hetian area of Xinjiang Uygur Autonomous Region.
  
  
  RESULTS
  Fourteen novel and 6 known single nucleotide polymorphism (SNPs), including 2 nonsynonymous SNPs (nsSNPs), in the STEAP4 gene were identified. Of the 3 representative SNPs, the nsSNP rs1981529 (Gly75Asp, 224A/G) was significantly associated with obesity phenotype (additive P/Pc = 0.001/0.006, dominant P/Pc = 0.003/0.018, odds ratio (OR) and 95% confidence interval (CI) adjusted for age, gender and drinking 0.755 (0.641 - 0.890) and 0.750 (0.621 - 0.907), respectively). By the multiple linear regression analysis, the quantitative phenotypes of BMI (P/Pc = 0.002/0.004) and waist circumference (P/Pc = 0.004/0.008) were found to be significantly associated with the genotypes of rs1981529 (Gly75Asp, 224A/G) in Uygur general population, and effect size (beta value) of one allele G of rs1981529 (Gly75Asp, 224A/G) was - 0.553 kg/m² for BMI and - 1.311 cm for waist circumference after controlling age, gender and drinking factors.
  
  
  CONCLUSIONS
  The present study shows an association of the common variation rs1981529 (Gly75Asp, 224A/G) in the STEAP4 gene with obesity in Uygur general population. Further studies should replicate the results using larger populations.
authors.affiliation: Hypertension Center, People's Hospital of Xinjiang Uygur Autonomous Region; Hypertension Institute of Xinjiang, Urumqi, Xinjiang 830001, China.
authors.forename: Yan-ying
authors.initials: YY
authors.lastname: Guo
authors.forename: Nan-fang
authors.initials: NF
authors.lastname: Li
authors.forename: Ling
authors.initials: L
authors.lastname: Zhou
authors.forename: Xiao-guang
authors.initials: XG
authors.lastname: Yao
authors.forename: Hong-mei
authors.initials: HM
authors.lastname: Wang
authors.forename: Ju-hong
authors.initials: JH
authors.lastname: Zhang
authors.forename: Wen-li
authors.initials: WL
authors.lastname: Luo
mesh_terms: D000328:Adult; D044466:Asian People; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D009765:Obesity / Q000235:genetics*; D010088:Oxidoreductases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D055105:Waist Circumference / Q000235:genetics
chemical_list: D008565:Membrane Proteins; D010088:Oxidoreductases; C503310:STEAP4 protein, human