title: Assembly and disassembly of the ESCRT-III membrane scission complex.
abstract: The ESCRT (endosomal sorting complex required for transport) pathway promotes the final membrane scission step at the end of cytokinesis, assists viral budding and generates multivesicular bodies (MVBs). These seemingly unrelated processes require a topologically similar membrane deformation and scission event that buds membranes/vesicles out of the cytoplasm. The topology of this budding reaction is 'opposite' to reactions that bud endocytic and secretory vesicles into the cytoplasm. Here we summarize recent findings that help to understand how the ESCRT machinery, in particular the ESCRT-III complex, assembles on its target membranes, executes membrane scission and is disassembled by the AAA-ATPase Vps4.
authors.affiliation: Division Cell Biology, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Manuel Alonso Y
authors.initials: MA
authors.lastname: Adell
authors.forename: David
authors.initials: D
authors.lastname: Teis
mesh_terms: D000074183:ATPases Associated with Diverse Cellular Activities; D000818:Animals; D002462:Cell Membrane / Q000235:genetics / Q000378:metabolism*; D048749:Cytokinesis / Q000502:physiology; D003593:Cytoplasm / Q000235:genetics / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology*; D056827:Endosomal Sorting Complexes Required for Transport / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D022142:Secretory Vesicles / Q000235:genetics / Q000378:metabolism*; D025262:Vacuolar Proton-Translocating ATPases / Q000235:genetics / Q000378:metabolism; D057074:Virus Release / Q000502:physiology; D014780:Viruses / Q000378:metabolism
chemical_list: D056827:Endosomal Sorting Complexes Required for Transport; D025262:Vacuolar Proton-Translocating ATPases; D000074183:ATPases Associated with Diverse Cellular Activities; C490305:VPS4A protein, human