title: The role of E. coli Nus-factors in transcription regulation and transcription:translation coupling: From structure to mechanism.
abstract: Bacterial transcription mediated by RNA polymerase (RNAP) is a highly regulated process and RNAP action is modulated during the different phases of initiation, elongation and termination by proteins such as the Escherichia coli Nus transcription-factors. Here we discuss the structural interplay and the mechanistic role of the Nus-factors that are directly involved in the processivity of elongation, transcription:translation coupling and termination, as well as the varying effects of these proteins on transcription under the influence of additional signals.
authors.affiliation: Lehrstuhl Biopolymere und Forschungszentrum für Bio-Makromoleküle; Universität Bayreuth; Bayreuth, Germany.
authors.forename: Björn M
authors.initials: BM
authors.lastname: Burmann
authors.forename: Paul
authors.initials: P
authors.lastname: Rösch