title: Next-generation human genetics.
abstract: The field of human genetics is being reshaped by exome and genome sequencing. Several lessons are evident from observing the rapid development of this area over the past 2 years, and these may be instructive with respect to what we should expect from 'next-generation human genetics' in the next few years.
authors.forename: Jay
authors.initials: J
authors.lastname: Shendure
mesh_terms: D059472:Exome; D030342:Genetic Diseases, Inborn / Q000175:diagnosis / Q000235:genetics; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods; D005826:Genetics, Medical; D015894:Genome, Human; D023281:Genomics / Q000379:methods; D006801:Humans; D017422:Sequence Analysis, DNA