title: [A case of undifferentiated colon cancer responding to FOLFIRI therapy].
abstract: We report a case of undifferentiated colon cancer treated with FOLFIRI therapy. A 69-year-old male had suffered from descending colon cancer. He underwent a left hemicolectomy with D3 dissection. Histopathologically, the tumor was undifferentiated carcinoma, and the cytology of ascites was positive. Peritoneal disseminations occurred soon after surgery, and these tumors did not respond to FOLFOX4 therapy. FOLFIRI therapy was employed, and it reduced the size of these tumors once. However, the therapy failed to control the tumor progression 2 months later. Although we started bevacizumab and S-1, the patient died 11 months after the operation. The present case demonstrates the efficacy of FOLFIRI therapy for undifferentiated colon cancer.
authors.affiliation: Dept. of Surgery, Kitakyushu Municipal Wakamatsu Hospital.
authors.forename: Kenji
authors.initials: K
authors.lastname: Fujiwara
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Nagayoshi
authors.forename: Chihiro
authors.initials: C
authors.lastname: Nakahara
authors.forename: Toru
authors.initials: T
authors.lastname: Yamasaki
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Iwashita
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000031:analogs & derivatives / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D017809:Fatal Outcome; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use; D008297:Male; D014057:Tomography, X-Ray Computed
chemical_list: D002955:Leucovorin; D005472:Fluorouracil; D002166:Camptothecin