title: [Urinary cystatin C as a biomarker of renal tubular injury].
abstract: Cystatin C (cysC) is an endogenous cysteine peptidase (proteinase) inhibitor that has been intensively investigated as a biomarker of kidney function for many years. It is freely filtered at the kidney glomerulus because of its small size and lack of cysC binding protein. A very small amount of cysC appears in the urine because of its total reabsorption in the proximal tubule and lack of secretion. Since 1985 cystatin C has been studied mainly in serum/plasma as an alternative biomarker to serum creatinine to estimate GFR. In this review we present the recent discoveries concerning urinary cystatin C determination as a tubular injury biomarker.
authors.affiliation: Katedra i Zakład Biochemii Farmaceutycznej Akademii Medycznej we Wrocławiu. warwas@biochfarm.am.wroc.pl
authors.forename: Maria
authors.initials: M
authors.lastname: Warwas
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Piwowar
mesh_terms: D058186:Acute Kidney Injury / Q000652:urine*; D015415:Biomarkers / Q000652:urine*; D055316:Cystatin C / Q000652:urine*; D005919:Glomerular Filtration Rate; D006801:Humans; D007677:Kidney Function Tests / Q000379:methods; D007684:Kidney Tubules / Q000502:physiology; D011237:Predictive Value of Tests
chemical_list: D015415:Biomarkers; D055316:Cystatin C