title: Neuronal (bi)polarity as a self-organized process enhanced by growing membrane.
abstract: Early in vitro and recent in vivo studies demonstrated that neuronal polarization occurs by the sequential formation of two oppositely located neurites. This early bipolar phenotype is of crucial relevance in brain organization, determining neuronal migration and brain layering. It is currently considered that the place of formation of the first neurite is dictated by extrinsic cues, through the induction of localized changes in membrane and cytoskeleton dynamics leading to deformation of the cells' curvature followed by the growth of a cylindrical extension (neurite). It is unknown if the appearance of the second neurite at the opposite pole, thus the formation of a bipolar cell axis and capacity to undergo migration, is defined by the growth at the first place, therefore intrinsic, or requires external determinants. We addressed this question by using a mathematical model based on the induction of dynamic changes in one pole of a round cell. The model anticipates that a second area of growth can spontaneously form at the opposite pole. Hence, through mathematical modeling we prove that neuronal bipolar axis of growth can be due to an intrinsic mechanism.
authors.affiliation: Department of Molecular and Developmental Genetics, VIB and Center for Human Genetics, Katholieke Universiteit Leuven, Leuven, Belgium. SilviaAdriana.Menchon@cme.vib-kuleuven.be
authors.forename: Silvia A
authors.initials: SA
authors.lastname: Menchón
authors.forename: Annette
authors.initials: A
authors.lastname: Gärtner
authors.forename: Pablo
authors.initials: P
authors.lastname: Román
authors.forename: Carlos G
authors.initials: CG
authors.lastname: Dotti
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology; D002465:Cell Movement; D016764:Cell Polarity / Q000502:physiology; D003599:Cytoskeleton / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D007150:Immunohistochemistry / Q000379:methods; D008567:Membranes, Artificial; D008954:Models, Biological; D008962:Models, Theoretical; D016501:Neurites / Q000378:metabolism; D009474:Neurons / Q000378:metabolism / Q000502:physiology*; D010641:Phenotype; D051381:Rats
chemical_list: D008567:Membranes, Artificial