title: G-CSF-producing malignant pleural mesothelioma: an autopsy case report with literature review.
abstract: This study reports a 54-year-old man who was a carpenter by occupation. He suffered from left chest and back pain and left pleural effusion. Peripheral blood showed granulocytosis and high serum titers of granulocyte-colony stimulating factor (G-CSF) and CYFRA. He died 20 months later. At autopsy, a pleural tumor located around the left lung and thickening of the pericardium, diaphragm, and esophagus by tumor infiltration was seen. The tumor proliferated in papillary and solid alveolar patterns by neoplastic cells. They were positive for calretinin, D2-40, CK5/6, HBME-1, G-CSF, CK19, and E-cadherin. He was diagnosed with G-CSF-producing epithelioid malignant pleural mesothelioma.
authors.affiliation: Department of Pathology, Mito Saiseikai General Hospital, 3-3-10 Futabadai, Mito, Ibaraki 311-4198, Japan. oka-k@gb3.so-net.ne.jp
authors.forename: Kuniyuki
authors.initials: K
authors.lastname: Oka
authors.forename: Gen
authors.initials: G
authors.lastname: Sarashina
authors.forename: Nobuo
authors.initials: N
authors.lastname: Yonekawa
authors.forename: Osamu
authors.initials: O
authors.lastname: Watanabe
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Miyao
authors.forename: Toshio
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Yatabe
mesh_terms: D001344:Autopsy; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis*; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D016066:Pleural Effusion, Malignant / Q000209:etiology; D010997:Pleural Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D016179:Granulocyte Colony-Stimulating Factor