title: Value of diffusion-weighted MRI in the differentiation of benign and malign breast lesions.
abstract: BACKGROUND
  Our purpose was to determine whether diffusion-weighted MR imaging (DWI) could be used in differentiation of benign and malign breast lesions.
  
  
  METHODS
  41 women patients were included in the study. 45 lesions were diagnosed by biopsy; 25 (55.5%) of these lesions were malignant and 20 (44.5%) were benign. The apparent diffusion coefficient (ADC) values of these lesions were prospectively compared with their histopathological results.
  
  
  RESULTS
  Differentiation of the malignant and benign masses revealed that the threshold value of the ADC was 1.0 x 10(-3) mm(2)/s, its sensitivity was demonstrated as 95%, specificity as 100%, positive predictive as 100%, negative predictive as 94% and accuracy rate as 97%.
  
  
  CONCLUSIONS
  DWI improves diagnostic accuracy of the conventional breast MRI. ADC measurements may be useful for differentiation of the malign and benign masses.
authors.affiliation: Department of Radiology, GATA Haydarpasa Teaching Hospital, Istanbul, Turkey. gunersonmez@hotmail.com
authors.forename: G
authors.initials: G
authors.lastname: Sonmez
authors.forename: F
authors.initials: F
authors.lastname: Cuce
authors.forename: H
authors.initials: H
authors.lastname: Mutlu
authors.forename: M
authors.initials: M
authors.lastname: Incedayi
authors.forename: E
authors.initials: E
authors.lastname: Ozturk
authors.forename: O
authors.initials: O
authors.lastname: Sildiroglu
authors.forename: M
authors.initials: M
authors.lastname: Velioglu
authors.forename: C C
authors.initials: CC
authors.lastname: Bashekim
authors.forename: E
authors.initials: E
authors.lastname: Kizilkaya
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000175:diagnosis*; D003627:Data Interpretation, Statistical; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity