title: Niacin-bound chromium increases life span in Zucker Fatty Rats.
abstract: Avoiding insulin resistance (IR) associated with aging might lengthen life span based on previous studies using caloric-restricted animals. We assessed whether consuming niacin-bound chromium (NBC) alone or in a formula containing other so-called "insulin sensitizers" would overcome various manifestations of aging and extend life span in Zucker Fatty Rats (ZFR). We compared many metabolic parameters of ZFR fed NBC alone (n=12) or NBC in a unique formula (n=10) to a control group (n=10). In addition to NBC, the formula contained Allium sativum, Momordica charantia, Trigonella foenum-graecum and Gymnema sylvestre. The formula group received roughly 1/2 as much NBC daily as the NBC group. At week 44, all rats still lived, and no abnormalities in blood count (CBC), renal, or liver functions were found. In the two treatment groups compared to control, circulating glucose levels were significantly lower, with a trend toward lower HbA1C. Relatively elevated cholesterol and triglyceride concentrations occurred in the formula group. Compared to control, the NBC group had increased average lifespan (21.8%), median lifespan (14.1%), 30th percentile survival (19.6%), and maximum lifespan (22%). Despite similar beneficial effects on the glucose and blood pressure systems, a difference in aging was also found when the NBC group was compared to the formula group. When all rats in the other two groups had died, four in the NBC group continued to live at least a month longer. We attribute lack of a similar aging effect in the formula group to either lower dosing of NBC and/or that various ingredients in the formula counteracted the antiaging effect(s) of NBC.
authors.affiliation: Georgetown University Medical Center, Department of Biochemistry/Physiology, Washington, D.C. 20057, United States. preusshg@georgetown.edu
authors.forename: Harry G
authors.initials: HG
authors.lastname: Preuss
authors.forename: Bobby
authors.initials: B
authors.lastname: Echard
authors.forename: Dallas
authors.initials: D
authors.lastname: Clouatre
authors.forename: Debasis
authors.initials: D
authors.lastname: Bagchi
authors.forename: Nicholas V
authors.initials: NV
authors.lastname: Perricone
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D002857:Chromium / Q000737:chemistry* / Q000494:pharmacology*; D006442:Glycated Hemoglobin / Q000378:metabolism; D009525:Niacin / Q000737:chemistry*; D051381:Rats; D011924:Rats, Zucker
chemical_list: D001786:Blood Glucose; D002857:Chromium; D006442:Glycated Hemoglobin; D009525:Niacin