title: Delayed graft function and cotrimoxazole.
abstract: Acute interstitial nephritis is an infrequent cause of early allograft dysfunction. Prophylactic trimethoprim sulfamethoxazole (cotrimoxazole) is frequently prescribed early in the course of kidney transplantation. Herein we have reported a case of delayed graft function associated with eosinophilia in which the renal biopsy showed interstitial mononuclear infiltrates with abundant eosinophils. An initial methylprednisolone course failed to lower the serum creatinine, but renal function and eosinophilia persistently improved following cotrimoxazole withdrawal and a second course of steroids. Cotrimoxazole acute interstitial nephritis is an infrequent but treatable cause of kidney allograft dysfunction, which should be included in the differential diagnosis of delayed renal allograft function.
authors.affiliation: Nephrology, IIS-Fundacion Jimenez Diaz and Autonoma University of de Madrid, Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Acuña
authors.forename: A
authors.initials: A
authors.lastname: Ramos
authors.forename: C
authors.initials: C
authors.lastname: Santonja
authors.forename: A
authors.initials: A
authors.lastname: Barat
authors.forename: J
authors.initials: J
authors.lastname: Egido
authors.forename: A
authors.initials: A
authors.lastname: Ortiz
mesh_terms: D000328:Adult; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000503:physiopathology / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced / Q000503:physiopathology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects*
chemical_list: D007166:Immunosuppressive Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination