title: Postdelivery changes in maternal and infant erythrocyte fatty acids in 3 populations differing in fresh water fish intakes.
abstract: BACKGROUND
  Long-chain polyunsaturated (LCP) fatty acids (FA) are important during infant development. Mother-to-infant FA-transport occurs at the expense of the maternal status. Maternal and infant FA-status change rapidly after delivery.
  
  
  METHODS
  Comparison of maternal (mRBC) and infant erythrocyte (iRBC)-FA-profiles at delivery and after 3 months exclusive breastfeeding in relation to freshwater-fish intakes. Approximation of de-novo-lipogenesis (DNL), stearoyl-CoA-desaturase (SCD), elongation-of-very-long-chain-FA-family-member-6 (Elovl-6), delta-5-desaturase (D5D) and delta-6-desaturase (D6D)-enzymatic activities from their product/essential-FA and product/substrate-ratios.
  
  
  CONCLUSIONS
  Increasing iRBC-14:0 derived from mammary-gland DNL. Decreasing mRBC-ω9, but increasing iRBC-ω9, suggest high ω9-FA-transfer via breastmilk. Decreasing (m+i)RBC-16:0, DNL- and SCD-activities, but increasing (m+i)RBC-18:0 and Elovl-6-activity suggest more pronounced postpartum decreases in DNL- and SCD-activities, compared to Elovl-6-activity. Increasing (m+i)RBC-18:3ω3, 20:5ω3, 22:5ω3, 18:2ω6, mRBC-20:4ω6 and (m+i)D5D-activity, but decreasing mRBC-22:6ω3 and (m+i)D6D-activity and dose-dependent changes in iRBC-22:6ω3 confirm that D6D-activity is rate-limiting and 22:6ω3 is important during lactation. Fish-intake related magnitudes of postpartum FA-changes suggest that LCPω3 influence DNL-, SCD- and desaturase-activities.
authors.affiliation: Laboratory Medicine, Room Y 3.181, University Medical Center Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands. remkokuipers@hotmail.com
authors.forename: Remko S
authors.initials: RS
authors.lastname: Kuipers
authors.forename: Martine F
authors.initials: MF
authors.lastname: Luxwolda
authors.forename: Wicklif S
authors.initials: WS
authors.lastname: Sango
authors.forename: Gideon
authors.initials: G
authors.lastname: Kwesigabo
authors.forename: D A Janneke
authors.initials: DA
authors.lastname: Dijck-Brouwer
authors.forename: Frits A J
authors.initials: FA
authors.lastname: Muskiet
mesh_terms: D000123:Acetyltransferases / Q000378:metabolism; D000328:Adult; D000818:Animals; D016022:Case-Control Studies; D004032:Diet; D004041:Dietary Fats / Q000378:metabolism*; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism*; D044943:Fatty Acid Desaturases / Q000378:metabolism; D000081031:Fatty Acid Elongases; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D005260:Female; D005399:Fishes; D005618:Fresh Water; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D050155:Lipogenesis; D008297:Male; D008460:Meat; D008875:Middle Aged; D008895:Milk, Human / Q000378:metabolism; D013636:Tanzania; D055815:Young Adult
chemical_list: D004041:Dietary Fats; C000630955:ELOVL6 protein, human; D005231:Fatty Acids, Unsaturated; D044943:Fatty Acid Desaturases; D000123:Acetyltransferases; D000081031:Fatty Acid Elongases