title: Apolipoprotein E-e4, processing speed, and white matter volume in a genetically enriched sample of midlife adults.
abstract: Healthy midlife children of a parent with Alzheimer's disease ([AD] N = 23; 9 male) participated in neuropsychological testing, and magnetic resonance imaging (MRI) of brain volumetrics were obtained. In all, 35% of the sample were apolipoprotein E (ApoE)-e4 positive (n = 8; 5 male). The ApoE-e4 group exhibited significantly slower performances on an executive function and processing speed measure and had less white matter volume than the non-ApoE-e4 group. Lesser white matter volume was significantly correlated with slower processing speed. Processing speed and changes in white matter volume might be indicators of preclinical decline in AD.
authors.affiliation: Department of Psychology, University of Massachusetts, Amherst, 01003, USA. ready@psych.umass.edu
authors.forename: Rebecca E
authors.initials: RE
authors.lastname: Ready
authors.forename: B
authors.initials: B
authors.lastname: Baran
authors.forename: M
authors.initials: M
authors.lastname: Chaudhry
authors.forename: K
authors.initials: K
authors.lastname: Schatz
authors.forename: J
authors.initials: J
authors.lastname: Gordon
authors.forename: R M C
authors.initials: RM
authors.lastname: Spencer
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D053327:Apolipoprotein E4 / Q000235:genetics*; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology; D016241:Child of Impaired Parents / Q000706:statistics & numerical data*; D003071:Cognition / Q000502:physiology*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006624:Hippocampus / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D015995:Prevalence; D012307:Risk Factors
chemical_list: D053327:Apolipoprotein E4; D006854:Hydrocortisone