title: Challenges for the treatment of diabetes mellitus.
abstract: The present review summarizes the existing literature data regarding the development of newer categories of antidiabetic agents, their mechanism of action and their clinical importance. In this paper, a review of the recent patents for the treatment of diabetes will be presented. In recent years significant achievements have been done, including the development of SGLT2 inhibitors, glucokinase activators as well as the role of free fatty acids and bile acid metabolism in the treatment of diabetes are reviewed.
authors.affiliation: 3rd Department of Internal Medicine and Center of Diabetes, General Hospital of Nikaia "Ag. anteleimon" - Piraeus, Greece. pathan@ath.forthnet.gr
authors.forename: Athanasia K
authors.initials: AK
authors.lastname: Papazafiropoulou
authors.forename: Marina S
authors.initials: MS
authors.lastname: Kardara
authors.forename: Stavros I
authors.initials: SI
authors.lastname: Pappas
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds; D001647:Bile Acids and Salts / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000819:agonists; D005941:Glucokinase / Q000378:metabolism; D005960:Glucosides / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D058990:Molecular Targeted Therapy / Q000379:methods; D010330:Patents as Topic; D011720:Pyrazoles / Q000009:adverse effects / Q000627:therapeutic use; D000077203:Sodium-Glucose Transporter 2 Inhibitors
chemical_list: D001559:Benzhydryl Compounds; D001647:Bile Acids and Salts; D005230:Fatty Acids, Nonesterified; D005960:Glucosides; D007004:Hypoglycemic Agents; D011720:Pyrazoles; D000077203:Sodium-Glucose Transporter 2 Inhibitors; C529054:dapagliflozin; D005941:Glucokinase; C532127:remogliflozin etabonate