title: [Osteoblast-osteoclast interaction mechanisms].
abstract: Bone tissue is constantly renewed by the coordinated action of osteoclasts and osteoblasts. Osteocytes have a prominent role in the onset of bone remodeling at selected sites of the skeleton. These and other osteoblastic cells produce a variety of mediators that modulate the differentiation of osteoclast precursors, a critical step for bone resorption to occur. Among them, M-CSF and RANKL are especially important.
authors.affiliation: Servicio de Medicina Interna, Hospital Universitario Marqués de Valdecilla-IFIMAV, Universidad de Cantabria, Santander, España. rianchoj@unican.es
authors.forename: José A
authors.initials: JA
authors.lastname: Riancho
authors.forename: Jesús
authors.initials: J
authors.lastname: Delgado-Calle
mesh_terms: D016723:Bone Remodeling / Q000502:physiology*; D002450:Cell Communication; D006801:Humans; D010006:Osteoblasts / Q000502:physiology*; D010010:Osteoclasts / Q000502:physiology*; D053244:Osteoprotegerin / Q000502:physiology; D053245:RANK Ligand / Q000502:physiology; D053246:Receptor Activator of Nuclear Factor-kappa B / Q000502:physiology
chemical_list: D053244:Osteoprotegerin; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B; C505688:TNFSF11 protein, human