title: [Limbic system and autonomic nervous system].
abstract: The viral transneuronal labeling method using pseudorabies virus (PRV) is an ideal technique for identifying the central sites that regulate the sympathetic nervous system. Regions were identified in limbic system such as extended amygdaloid complex, lateral septum, infralimbic, insular, ventromedial temporal cortical regions, as well as in several hypothalamic and brain stem nuclei. Emotional stress causes rapid and transient expression of immediate early genes (IEGs) such as c-Fos in the brain, and the monitoring of IEGs has enabled the visualization of the neurocircuitry of stress. By a comparison of the data from the separate PRV and c-Fos neuroanatomical labeling techniques, the central sites which regulate emotional stress-induced sympathoadrenal activation can be deduced. Estrogen receptors are expressed in the brain, where estrogen modulates central nervous function and autonomic nervous function. Estrogen attenuated the stress-induced c-Fos expression in medial amygdaloid nucleus, paraventricular hypothalamic nucleus; these same regions contain central sympathetic neurons and neurons with immunoreactive estrogen receptors.
authors.affiliation: Department of Anatomy and Cell Biology, Wakayama Medical University School of Medicine.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ueyama
authors.forename: Emiko
authors.initials: E
authors.lastname: Senba
mesh_terms: D000679:Amygdala / Q000502:physiology; D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology*; D004967:Estrogens / Q000502:physiology; D011558:Herpesvirus 1, Suid; D006801:Humans; D007031:Hypothalamus / Q000502:physiology; D008032:Limbic System / Q000502:physiology*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D011960:Receptors, Estrogen / Q000502:physiology; D012149:Restraint, Physical / Q000502:physiology; D013312:Stress, Physiological / Q000502:physiology
chemical_list: D004967:Estrogens; D016760:Proto-Oncogene Proteins c-fos; D011960:Receptors, Estrogen