title: Clinicopathological characteristics of intrahepatic cholangiocarcinoma in patients with cirrhosis.
abstract: OBJECTIVE
  The purpose of this study was to explore the clinicopathological characteristics of intrahepatic cholangiocarcinoma (ICC) in patients with cirrhosis.
  
  
  METHODS
  A total of 155 patients with ICC were divided into those with cirrhosis (n=52) and those without cirrhosis (n=103). We compared the clinicopathological features of patients in both groups.
  
  
  RESULTS
  The prevalence of HBsAg seropositivity and hepatolithiasis in ICC patients with cirrhosis was higher than that in patients without cirrhosis. Compared with noncirrhotic patients, cirrhotic patients had a higher incidence of reduced albumin (46.1% vs. 25.2%, p<0.008) and elevated total bilirubin (TBIL) levels (44.2% vs. 24.3%, p=0.011). The resectability rate in cirrhotic patients was lower than that in noncirrhotic patients (63.7% vs. 80.6%, p=0.033).
  
  
  CONCLUSIONS
  Among ICC patients, we found marked differences in clinicopathological characteristics and therapeutic approaches between cirrhotic and noncirrhotic patients. ICC patients with cirrhosis may have poorer prognosis than those without cirrhosis.
authors.affiliation: Department of General Surgery, Central South University, China.
authors.forename: Ya-Yong
authors.initials: YY
authors.lastname: Li
authors.forename: Dao-Jin
authors.initials: DJ
authors.lastname: Chen
authors.forename: Xiao-Rong
authors.initials: XR
authors.lastname: Li
authors.forename: Bu-Ning
authors.initials: BN
authors.lastname: Tian
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Liu
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.forename: Hao
authors.initials: H
authors.lastname: Li
mesh_terms: D000704:Analysis of Variance; D001650:Bile Duct Neoplasms; D001653:Bile Ducts, Intrahepatic; D016009:Chi-Square Distribution; D018281:Cholangiocarcinoma / Q000150:complications / Q000473:pathology*; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000209:etiology / Q000473:pathology*; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis