title: [Mitotane as possible cause of acute intermittent porphyria].
abstract: A 54 year-old woman with acute intermittent porphyria (AIP) developed an attack of porphyria after 156 days of treatment with mitotane following a non-radical adrenalectomy for adrenocortical carcinoma. Mitotane therapy was discontinued but the attack of porphyria persisted for more than four months and included episodes with severe metabolic and neurologic toxicities. Mitotane is probably porphyrinogenic for patients with AIP.
authors.affiliation: Medicinsk Afdeling, Orkdal Sygehus, St. Olavs Hospital, 7300 Orkanger, Norge. finn.edler.von.eyben@stolav.no
authors.forename: Finn Edler
authors.initials: FE
authors.lastname: von Eyben
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000188:drug therapy; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D005260:Female; D006801:Humans; D008875:Middle Aged; D008939:Mitotane / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D017118:Porphyria, Acute Intermittent / Q000139:chemically induced*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D008939:Mitotane