title: An efficient visible light controlled protein delivery system.
abstract: A visible light triggered protein delivery system has been assembled through hydroxyl coordinated onto titania nanoparticles. Biomolecules such as hemoglobin (Hb) can be controlled-released from the hybrid material TiO(2)-DB-Hb by switching visible light on/off. The released Hb not only retains its senior structure but also can fulfil the enzymatic bioactivity. Controlled delivery of Hb stems from the scission of the Ti-O coordination bond with the aid of photo-inducing electron transfer property of titania.
authors.affiliation: Eco-materials and Renewable Energy Research Center (REREC), National Laboratory of Solid State Microstructure, Nanjing University, Nanjing, 210093, People's Republic of China.
authors.forename: Leilei
authors.initials: L
authors.lastname: Luo
authors.forename: Yong
authors.initials: Y
authors.lastname: Guo
authors.forename: Juncheng
authors.initials: J
authors.lastname: Yang
authors.forename: Yijun
authors.initials: Y
authors.lastname: Liu
authors.forename: Sheng
authors.initials: S
authors.lastname: Chu
authors.forename: Fei
authors.initials: F
authors.lastname: Kong
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Zou
mesh_terms: D003692:Delayed-Action Preparations / Q000737:chemistry / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry; D006454:Hemoglobins / Q000737:chemistry / Q000378:metabolism*; D062385:Hydroxybenzoates / Q000737:chemistry; D008027:Light; D008958:Models, Molecular; D053758:Nanoparticles / Q000737:chemistry; D011487:Protein Conformation; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006454:Hemoglobins; D062385:Hydroxybenzoates; C009495:titanium dioxide; C009091:protocatechuic acid; D014025:Titanium