title: [Review on progress of research on drug releasing mechanism of chitosan microspheres].
abstract: Variety of drugs-loaded chitosan microspheres have been used as sustained release carrier in recent years, which has shown a good prospect in biomedical field. Therefore, chitosan microspheres have been one of the research hotspots in controlled release drug delivery system. Nowadays the research in releasing mechanism of drug-loaded chitosan microspheres lags obviously behind the research in preparation and application. Moreover further research in drug releasing mechanism of chitosan microspheres is beneficial to understanding of drug releasing behavior and to analyzing the influencing factors, and the further research is also important to the preparation and application of chitosan microspheres for drug sustained-release. The present paper comprehensively introduces the drug releasing mechanism, describes drug release behavior and analyzes the main releasing releasing influencing factors on the releasing process.
authors.affiliation: Institute of Material Science and Technology, Chengdu University of Technology, Chengdu 610059, China. ljfsc@163.com
authors.forename: Junfeng
authors.initials: J
authors.lastname: Li
authors.forename: Qin
authors.initials: Q
authors.lastname: Zou
authors.forename: Xuefei
authors.initials: X
authors.lastname: Lai
mesh_terms: D000284:Administration, Oral; D048271:Chitosan / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008863:Microspheres
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D048271:Chitosan