title: Microwave-assisted solventless reaction of iridium-catalyzed alkylation of amines with alcohols in the absence of base.
abstract: Microwave-assisted iridium catalyzed alkylation of amines with alcohols was undertaken under solvent-free and base-free conditions. Such alkylation reactions are green, atom-economic, and effective for mono-, di-, and triaklyation of amines. Good isolated yields were obtained for mono- and dialkylated amines using stoichiometric amounts of amines and alcohols, in the presence of 1 mol % [Cp*IrCl(2)](2). Reasonable yields of trialkylated products were obtained using 4 equiv of alcohols.
authors.affiliation: School of Pharmacy, Fudan University, Shanghai, 201203, PR China.
authors.forename: Weixing
authors.initials: W
authors.lastname: Zhang
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Dong
authors.forename: Weili
authors.initials: W
authors.lastname: Zhao
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000478:Alkylation; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D007495:Iridium / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure
chemical_list: D000438:Alcohols; D000588:Amines; D007495:Iridium