title: Bullous systemic lupus erythematosus.
abstract: Bullous systemic lupus erythematosus (BSLE) is a rare bullous dermatosis in patients with systemic lupus erythematosus. It is characterized by clinical and histologic features, resembling either bullous pemphigoid or dermatitis herpetiformis, and a heterogeneous immunologic profile, characterized by autoimmunity to components of type VII collagen, much like epidermolysis bullosa acquisita. As understanding of the pathology of this interesting dermatologic condition has evolved, so too have criteria and profiling of BSLE. The distinct clinical, histologic, and immunologic features of BSLE represent a unique bullous disease phenotype.
authors.affiliation: Department of Dermatology, St George Hospital, Gray Street, Sydney, NSW 2217, Australia.
authors.forename: Deshan F
authors.initials: DF
authors.lastname: Sebaratnam
authors.forename: Dédée F
authors.initials: DF
authors.lastname: Murrell
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001323:Autoantibodies / Q000276:immunology; D024143:Collagen Type VII / Q000276:immunology; D003622:Dapsone / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D012872:Skin Diseases, Vesiculobullous / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000305:Adrenal Cortex Hormones; D001323:Autoantibodies; D024143:Collagen Type VII; D003879:Dermatologic Agents; D007166:Immunosuppressive Agents; D003622:Dapsone