title: 14-3-3 proteins in neurodegeneration.
abstract: Among the first reported functions of 14-3-3 proteins was the regulation of tyrosine hydroxylase (TH) activity suggesting a possible involvement of 14-3-3 proteins in Parkinson's disease. Since then the relevance of 14-3-3 proteins in the pathogenesis of chronic as well as acute neurodegenerative diseases, including Alzheimer's disease, polyglutamine diseases, amyotrophic lateral sclerosis and stroke has been recognized. The reported function of 14-3-3 proteins in this context are as diverse as the mechanism involved in neurodegeneration, reaching from basal cellular processes like apoptosis, over involvement in features common to many neurodegenerative diseases, like protein stabilization and aggregation, to very specific processes responsible for the selective vulnerability of cellular populations in single neurodegenerative diseases. Here, we review what is currently known of the function of 14-3-3 proteins in nervous tissue focussing on the properties of 14-3-3 proteins important in neurodegenerative disease pathogenesis.
authors.affiliation: Department of Neurology, University of Ulm, Helmholtzstr. 8/1, 89081 Ulm, Germany. petra.steinacker@uni-ulm.de
authors.forename: Petra
authors.initials: P
authors.lastname: Steinacker
authors.forename: Alastair
authors.initials: A
authors.lastname: Aitken
authors.forename: Markus
authors.initials: M
authors.lastname: Otto
mesh_terms: D048948:14-3-3 Proteins / Q000378:metabolism*; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D004268:DNA-Binding Proteins / Q000378:metabolism; D059865:Endoplasmic Reticulum Stress; D006801:Humans; D009420:Nervous System / Q000378:metabolism / Q000473:pathology*; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D018384:Oxidative Stress; D055550:Protein Stability; D016601:RNA-Binding Proteins / Q000378:metabolism; D015398:Signal Transduction; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D048948:14-3-3 Proteins; D004268:DNA-Binding Proteins; D016601:RNA-Binding Proteins; D014446:Tyrosine 3-Monooxygenase