title: Tollip: a multitasking protein in innate immunity and protein trafficking.
abstract: The Toll-interacting protein (Tollip) is a critical regulator of Toll-like receptor (TLR)-mediated innate immune responses. Tollip modulates TLR signaling and membrane trafficking processes through its interaction with both proteins and phosphoinositides. Here, I discuss the multitasking role of Tollip associated with its modular architecture.
authors.affiliation: Protein Signaling Domains Laboratory, Department of Biological Sciences, Virginia Tech, 1981 Kraft Drive, Room 2007, Blacksburg, VA 24061, USA. capellut@vt.edu
authors.forename: Daniel G S
authors.initials: DG
authors.lastname: Capelluto
mesh_terms: D006801:Humans; D007113:Immunity, Innate; D047908:Intracellular Signaling Peptides and Proteins / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*; D010716:Phosphatidylinositols / Q000378:metabolism; D011485:Protein Binding; D021381:Protein Transport; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000276:immunology / Q000378:metabolism*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D010716:Phosphatidylinositols; C410602:TOLLIP protein, human; D051193:Toll-Like Receptors