title: Organochlorine pollutants in human blood and their relation with age, gender and habitat from North-east India.
abstract: Organochlorine pesticides (OCPs) have been beneficial to man and environment but their inadvertent use has caused considerable harm to human health. Despite the proliferation of different types of pesticides, organochlorines such as HCH and DDT still account for two third of the total consumption in India because of their low cost and versatility in action again various pests. Since, Assam, a state in North-eastern part of India is an endemic area with perennial transmission where mosquito borne diseases are serious health problems; these pesticides are still being used in huge quantities in vector control as well as in agriculture. A total of 331 human blood samples were collected from district Nagaon and Dibrugarh of Assam to determine the residue levels of DDT and HCH in human blood. The concentrations of selected persistent organochlorine pollutants were measured with gas chromatography-electron capture detector. The results demonstrated that the mean levels of total DDT and HCH were 743 μg L(-1) and 627 μg L(-1) for district Nagaon while 417 μg L(-1) and 348 μg L(-1) for district Dibrugarh. The difference of total HCH and total DDT between these two districts was found to be highly significant (P<0.0001). Among DDT metabolites, the same trend was observed for both the districts as p,p-DDT was the principal component contributed 41% for Nagaon and 58% for Dibrugarh. In case of HCH residues, for Nagaon, β-HCH was the predominant contaminant comprised more than 34% while for Dibrugarh, it was α-HCH that was contributing 43% of total HCH concentration.
authors.affiliation: Department of Environmental Sciences, Hemwati Nandan Bahuguna Garhwal University (A Central University), Srinagar Garhwal-246174, Uttarakhand, India. saffron2882@gmail.com
authors.forename: K
authors.initials: K
authors.lastname: Mishra
authors.forename: Ramesh C
authors.initials: RC
authors.lastname: Sharma
authors.forename: Sudhir
authors.initials: S
authors.lastname: Kumar
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002849:Chromatography, Gas; D003634:DDT / Q000097:blood; D017753:Ecosystem; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D006581:Hexachlorobenzene / Q000097:blood; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010575:Pesticides / Q000097:blood*; D025341:Principal Component Analysis; D012737:Sex Factors
chemical_list: D004785:Environmental Pollutants; D006843:Hydrocarbons, Chlorinated; D010575:Pesticides; D006581:Hexachlorobenzene; D003634:DDT