title: Biomimetic total synthesis of angelicoin A and B via a palladium-catalyzed decarboxylative prenylation-aromatization sequence.
abstract: Five-step total syntheses of angelicoin A and B from 2,2,6-trimethyl-4-dioxinone are reported using late stage biomimetic aromatization reactions via diketo-dioxinones as intermediates. In addition, with angelicoin A, this aromatization was coupled with a palladium-catalyzed decarboxylative prenylation in a one-pot sequence as the key step.
authors.affiliation: Department of Chemistry, Imperial College , London, SW7 2AZ, England, United Kingdom.
authors.forename: Katie
authors.initials: K
authors.lastname: Anderson
authors.forename: Frederick
authors.initials: F
authors.lastname: Calo
authors.forename: Toni
authors.initials: T
authors.lastname: Pfaffeneder
authors.forename: Andrew J P
authors.initials: AJ
authors.lastname: White
authors.forename: Anthony G M
authors.initials: AG
authors.lastname: Barrett
mesh_terms: D040761:Biomimetic Materials / Q000138:chemical synthesis*; D002384:Catalysis; D003374:Coumarins / Q000138:chemical synthesis*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D054876:Prenylation
chemical_list: D003374:Coumarins; C511400:angelicoin A; C511399:angelicoin B; D010165:Palladium