title: Differential effects of laminin isoforms on axon and dendrite development in hippocampal neurons.
abstract: Laminins play an important role in neuronal development. However, the effects of each laminin isoform on neurite morphology remain unclear. Here, we examined the effects of particular laminin (LN) isoforms on hippocampal neuron morphology. We found that LN-511 remarkably promoted elongation of both axons and dendrites, but reduced the number of dendrites. LN-511 E8 fragment, which includes the integrin-binding region, promoted axon and dendrite outgrowth and increased the dendrite number, although its effect on axon and dendrite elongation was smaller than that of full-length LN-511. These results suggest that LN-511 regulates axon and dendrite development by integrin-dependent and -independent mechanisms.
authors.affiliation: KAN Research Institute, Kobe, Japan.
authors.forename: Eri
authors.initials: E
authors.lastname: Fusaoka-Nishioka
authors.forename: Chisei
authors.initials: C
authors.lastname: Shimono
authors.forename: Yukimasa
authors.initials: Y
authors.lastname: Taniguchi
authors.forename: Aki
authors.initials: A
authors.lastname: Togawa
authors.forename: Akio
authors.initials: A
authors.lastname: Yamada
authors.forename: Eiji
authors.initials: E
authors.lastname: Inoue
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Onodera
authors.forename: Kiyotoshi
authors.initials: K
authors.lastname: Sekiguchi
authors.forename: Toshio
authors.initials: T
authors.lastname: Imai
mesh_terms: D000818:Animals; D001369:Axons / Q000648:ultrastructure*; D003712:Dendrites / Q000648:ultrastructure*; D006624:Hippocampus / Q000196:embryology*; D007797:Laminin / Q000378:metabolism*; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000648:ultrastructure*; D020033:Protein Isoforms; D051381:Rats
chemical_list: D007797:Laminin; D020033:Protein Isoforms