title: Calendula extract: effects on mechanical parameters of human skin.
abstract: The aim of this study was to evaluate the effects of newly formulated topical cream of Calendula officinalis extract on the mechanical parameters of the skin by using the cutometer. The Cutometer 580 MPA is a device that is designed to measure the mechanical properties of the skin in response to the application of negative pressure. This non-invasive method can be useful for objective and quantitative investigation of age related changes in skin, skin elasticity, skin fatigue, skin hydration, and evaluation of the effects of cosmetic and antiaging topical products. Two creams (base and formulation) were prepared for the study. Both the creams were applied to the cheeks of 21 healthy human volunteers for a period of eight weeks. Every individual was asked to come on week 1, 2, 3, 4, 5, 6, 7, and 8 and measurements were taken by using Cutometer MPA 580 every week. Different mechanical parameters of the skin measured by the cutometer were; R0, R1, R2, R5, R6, R7, and R8. These were then evaluated statistically to measure the effects produced by these creams. Using ANOVA, and t-test it was found that R0, and R6 were significant (p <0.05) whereas R1, R2, R5, R7, R8 were insignificant (p > 0.05). The instrumental measurements produced by formulation reflected significant improvements in hydration and firmness of skin.
authors.affiliation: Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
authors.forename: Naveed
authors.initials: N
authors.lastname: Akhtar
authors.forename: Shahiq Uz
authors.initials: SU
authors.lastname: Zaman
authors.forename: Barkat Ali
authors.initials: BA
authors.lastname: Khan
authors.forename: Muhammad Naeem
authors.initials: MN
authors.lastname: Amir
authors.forename: Muhammad Ali
authors.initials: MA
authors.lastname: Ebrahimzadeh
mesh_terms: D000328:Adult; D001696:Biomechanical Phenomena; D020838:Calendula / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D003358:Cosmetics; D004548:Elasticity / Q000187:drug effects; D004643:Emollients / Q000494:pharmacology; D004655:Emulsions; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D012867:Skin / Q000737:chemistry / Q000187:drug effects*; D015595:Skin Aging / Q000187:drug effects; D055815:Young Adult
chemical_list: D003358:Cosmetics; D004643:Emollients; D004655:Emulsions; D010936:Plant Extracts