title: Report of results obtained in 2,934 women using donor sperm: donor insemination versus in vitro fertilization according to indication.
abstract: OBJECTIVE
  To demonstrate that the use of donor sperm leads to varying outcome rates and that its use has evolved.
  
  
  METHODS
  Retrospective observational cohort study.
  
  
  METHODS
  University-affiliated private IVF setting.
  
  
  METHODS
  Women (2,934) undergoing donor insemination (DI) or IVF with donor sperm (IVF-D).
  
  
  METHODS
  None.
  
  
  METHODS
  We evaluated the distribution of the clinical indications for the use of donated sperm, studying the reproductive outcome.
  
  
  RESULTS
  A total of 1,663 DI (57%) and 1,271 IVF-D (43%) were performed. There were significant differences in the indications for the use of donated sperm (DI vs. IVF-D). Regarding pregnancy rates (PR), cases of nonobstructive azoospermia presented the highest rate (29.1%), whereas cases of intracytoplasmic sperm injection (ICSI) failures and single women showed rates of 27.6% and 22.6%, respectively. Meanwhile, patients with ICSI failures achieved the highest PRs in IVF cycles (48.7%), whereas nonobstructive azoospermia and single women showed rates of 42.0% and 38.2%, respectively. There have been significant increases in the use of donated sperm in single women.
  
  
  CONCLUSIONS
  Single women, which also represented the oldest group, show a lower probability of achieving pregnancy, and thus represent a subfertile population. Associated factors could include advanced maternal age.
authors.affiliation: Instituto Universitario IVI, Universidad de Valencia, Valencia, Spain.
authors.forename: Thamara
authors.initials: T
authors.lastname: Viloria
authors.forename: Nicolas
authors.initials: N
authors.lastname: Garrido
authors.forename: Francisco
authors.initials: F
authors.lastname: Minaya
authors.forename: José
authors.initials: J
authors.lastname: Remohí
authors.forename: Manuel
authors.initials: M
authors.lastname: Muñoz
authors.forename: Marcos
authors.initials: M
authors.lastname: Meseguer
mesh_terms: D000328:Adult; D053713:Azoospermia / Q000503:physiopathology / Q000628:therapy*; D016009:Chi-Square Distribution; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects; D006801:Humans; D007316:Insemination, Artificial, Heterologous / Q000009:adverse effects; D016015:Logistic Models; D008297:Male; D008423:Maternal Age; D016017:Odds Ratio; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012847:Single Person; D013030:Spain; D020554:Sperm Injections, Intracytoplasmic; D013094:Spermatozoa; D014019:Tissue Donors; D016896:Treatment Outcome