title: Structure and function of the bacterial AAA protease FtsH.
abstract: Proteolysis of regulatory proteins or key enzymes of biosynthetic pathways is a universal mechanism to rapidly adjust the cellular proteome to particular environmental needs. Among the five energy-dependent AAA(+) proteases in Escherichia coli, FtsH is the only essential protease. Moreover, FtsH is unique owing to its anchoring to the inner membrane. This review describes the structural and functional properties of FtsH. With regard to its role in cellular quality control and regulatory circuits, cytoplasmic and membrane substrates of the FtsH protease are depicted and mechanisms of FtsH-dependent proteolysis are discussed.
authors.affiliation: Lehrstuhl für Biologie der Mikroorganismen, Ruhr-Universität Bochum, Germany.
authors.forename: Sina
authors.initials: S
authors.lastname: Langklotz
authors.forename: Ulrich
authors.initials: U
authors.lastname: Baumann
authors.forename: Franz
authors.initials: F
authors.lastname: Narberhaus
mesh_terms: D049069:ATP-Dependent Proteases / Q000737:chemistry* / Q000378:metabolism; D000595:Amino Acid Sequence; D018407:Bacterial Physiological Phenomena; D017124:Conserved Sequence; D029968:Escherichia coli Proteins / Q000737:chemistry* / Q000378:metabolism; D008070:Lipopolysaccharides / Q000096:biosynthesis; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism; D008969:Molecular Sequence Data; D020836:Protein Structure, Quaternary; D017434:Protein Structure, Tertiary; D059748:Proteolysis; D013312:Stress, Physiological
chemical_list: D029968:Escherichia coli Proteins; D008070:Lipopolysaccharides; D008565:Membrane Proteins; D049069:ATP-Dependent Proteases; C513383:FtsH protein, E coli