title: Pou5f1/oct4 in pluripotency control: insights from zebrafish.
abstract: Gastrulation in vertebrates is a conserved process, which involves transition from cellular pluripotency to early precursors of ectoderm, mesoderm, and endoderm. Pluripotency control during this stage is far from being understood. Recent genetic and transcriptomic studies in zebrafish suggest that the core pluripotency transcription factors (TFs) Pou5f1 and TFs of the SoxB1 group are critically involved in large-scale temporal coordination of gene expression during gastrulation. A significant number of evolutionary conserved target genes of Pou5f1 in zebrafish are also involved in stem-cell circuit in mammalian ES cell cultures. Here, I will review the roles of Pou5f1 in development and discuss the evolutionary conservation of Pou5f1 functions and their relation to pluripotency control.
authors.affiliation: Developmental Biology, Institute Biology I, Faculty of Biology, University of Freiburg, Hauptstrasse 1, D-79104 Freiburg, Germany. daria.onichtchouk@biologie.uni-freiburg.de
authors.forename: Daria
authors.initials: D
authors.lastname: Onichtchouk
mesh_terms: D000818:Animals; D004475:Ectoderm / Q000378:metabolism; D053595:Embryonic Stem Cells / Q000378:metabolism; D004707:Endoderm / Q000378:metabolism; D019143:Evolution, Molecular; D054262:Gastrulation; D018507:Gene Expression Regulation, Developmental; D050814:Octamer Transcription Factor-3 / Q000235:genetics* / Q000378:metabolism; D010641:Phenotype; D055748:SOXB1 Transcription Factors / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D015027:Zebrafish / Q000196:embryology* / Q000235:genetics* / Q000378:metabolism; D029961:Zebrafish Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D050814:Octamer Transcription Factor-3; C085437:Pou5f3 protein, zebrafish; D055748:SOXB1 Transcription Factors; D029961:Zebrafish Proteins