title: Erythrocytes carotenoids after astaxanthin supplementation in middle-aged and senior Japanese subjects.
abstract: A randomized, double-blind human trial was conducted to assess the effect of 4- or 12-week astaxanthin supplementation (1 or 3 mg/day) on the carotenoid compositions of erythrocytes in Japanese middle-aged and senior subjects. Erythrocyte astaxanthin concentrations after 4- or 12-weeks of supplementation (3 mg/day) was significantly higher than after placebo or 1 mg astaxanthin supplementations. No differences were observed in either the carotenoid compositions or the phospholipid hydroperoxide concentrations in erythrocytes after astaxanthin intake in both the 1 and 3 mg/day groups.
authors.affiliation: Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Japan. miyazawa@biochem.tohoku.ac.jp
authors.forename: Taiki
authors.initials: T
authors.lastname: Miyazawa
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Nakagawa
authors.forename: Fumiko
authors.initials: F
authors.lastname: Kimura
authors.forename: Akira
authors.initials: A
authors.lastname: Satoh
authors.forename: Teruo
authors.initials: T
authors.lastname: Miyazawa
mesh_terms: D000328:Adult; D000368:Aged; D002338:Carotenoids / Q000378:metabolism*; D004311:Double-Blind Method; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism*; D017022:Flow Injection Analysis; D006801:Humans; D007564:Japan; D008875:Middle Aged; D053719:Tandem Mass Spectrometry; D024341:Xanthophylls / Q000494:pharmacology
chemical_list: D024341:Xanthophylls; D002338:Carotenoids; C005948:astaxanthine