title: Design and synthesis of a library of chemokine antagonists.
abstract: A library of chemokine antagonists has been synthesized using a combination of solid and solution-phase chemistry. Structures of known chemokine antagonists were used to produce a pharmacophore which served to guide monomer selection. Several combinations of monomers have resulted in providing novel chemokine antagonists which in some cases display dual chemokine receptor antagonism.
authors.affiliation: Global Discovery Chemistry, Novartis Institutes of Biomedical Research, Horsham Research Centre, Wimblehurst Road, Horsham, West Sussex RH12 5AB, UK. gurdip.bhalay@novartis.com
authors.forename: Gurdip
authors.initials: G
authors.lastname: Bhalay
authors.forename: Birgit
authors.initials: B
authors.lastname: Albrecht
authors.forename: Mohammed
authors.initials: M
authors.lastname: Akhlaq
authors.forename: Urs
authors.initials: U
authors.lastname: Baettig
authors.forename: David
authors.initials: D
authors.lastname: Beer
authors.forename: Zarin
authors.initials: Z
authors.lastname: Brown
authors.forename: Steven
authors.initials: S
authors.lastname: Charlton
authors.forename: Andrew
authors.initials: A
authors.lastname: Dunstan
authors.forename: Michelle
authors.initials: M
authors.lastname: Bradley
authors.forename: Peter
authors.initials: P
authors.lastname: Gedeck
authors.forename: Angela
authors.initials: A
authors.lastname: Glen
authors.forename: Trevor
authors.initials: T
authors.lastname: Howe
authors.forename: Thomas
authors.initials: T
authors.lastname: Keller
authors.forename: Juliet
authors.initials: J
authors.lastname: Leighton-Davies
authors.forename: Alice
authors.initials: A
authors.lastname: Li
authors.forename: Clive
authors.initials: C
authors.lastname: McCarthy
authors.forename: Cecile
authors.initials: C
authors.lastname: Mocquet
authors.forename: Charles
authors.initials: C
authors.lastname: Owen
authors.forename: Paul
authors.initials: P
authors.lastname: Nicklin
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Rosethorne
mesh_terms: D000818:Animals; D002460:Cell Line; D018925:Chemokines / Q000037:antagonists & inhibitors*; D006224:Cricetinae; D003412:Cricetulus; D015195:Drug Design; D054852:Small Molecule Libraries
chemical_list: D018925:Chemokines; D054852:Small Molecule Libraries