title: FORMIN a link between kinetochores and microtubule ends.
abstract: The mammalian diaphanous-related (mDia) formin proteins are well known for their actin-nucleation and filament-elongation activities in mediating actin dynamics. They also directly bind to microtubules and regulate microtubule stabilization at the leading edge of the cell during cell migration. Recently, the formin mDia3 was shown to associate with the kinetochore and to contribute to metaphase chromosome alignment, a process in which kinetochores form stable attachments with growing and shrinking microtubules. We suggest that the formin mDia3 could contribute to the regulation of kinetochore-bound microtubule dynamics, in coordination with attachment via its own microtubule-binding activity, as well as via its interaction with the tip-tracker EB1 (end-binding protein 1).
authors.affiliation: Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA. ym2183@columbia.edu
authors.forename: Yinghui
authors.initials: Y
authors.lastname: Mao
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D002875:Chromosomes / Q000378:metabolism; D000080865:Formins; D006801:Humans; D018386:Kinetochores / Q000378:metabolism*; D008677:Metaphase; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism*; D008954:Models, Biological
chemical_list: D002352:Carrier Proteins; C491462:DIAPH2 protein, human; D000080865:Formins; C500985:MAPRE1 protein, human; D008869:Microtubule-Associated Proteins