title: Phadiatop Infant(®)  detects IgE-mediated diseases among pre-school children: a prospective study.
abstract: BACKGROUND
  IgE-sensitization to food and inhalant allergens may precede and accompany the appearance of clinical symptoms of allergic diseases. The aim was to study the diagnostic capacity of Phadiatop(®) Infant (Phinf) for detecting IgE-sensitization at 5 yr of age and further to evaluate the predictive capacity of Phinf longitudinally with regard to sensitization and allergic symptoms in pre-school children.
  
  
  METHODS
  Two hundred and one children with complete data on sIgE testing for 10 individual allergens, Phinf analyses, and clinical evaluations at 2 and 5 yr of age were evaluated.
  
  
  RESULTS
  The diagnostic performance of Phinf, applied at the age of 5 and compared to specific IgE testing, gave a sensitivity of 84% and a specificity of 98%. The positive and negative predictive values were 97% and 92%, respectively. A positive Phinf test at 2 yr increased the odds 35.6-fold (95% CI 11.8-107) for IgE-sensitization and 14.7-fold (95% CI 4.4-49.7) for any allergic symptom at 5 yr of age. The association (OR) between Phinf and current symptoms was, at 2 and 5 yr of age, 3.6 (95% CI 1.6-7.9) and 18.4 (95% CI 7.4-45.8), respectively.
  
  
  CONCLUSIONS
  Phinf seems to be a reliable tool for predicting future sensitization as well as allergic symptoms in young children.
authors.affiliation: Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet and Sachs' Children's Hospital, Stockholm, Sweden. caroline.nilsson@sodersjukhuset.se
authors.forename: Caroline
authors.initials: C
authors.lastname: Nilsson
authors.forename: Gunnar
authors.initials: G
authors.lastname: Lilja
authors.forename: Monica
authors.initials: M
authors.lastname: Nordlund
authors.forename: Malin
authors.initials: M
authors.lastname: Berthold
authors.forename: Magnus P
authors.initials: MP
authors.lastname: Borres
mesh_terms: D002675:Child, Preschool; D042241:Early Diagnosis; D005260:Female; D006403:Hematologic Tests / Q000379:methods*; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis* / Q000276:immunology; D007073:Immunoglobulin E / Q000097:blood*; D007158:Immunologic Techniques / Q000379:methods*; D008297:Male; D011446:Prospective Studies; D012680:Sensitivity and Specificity
chemical_list: D007073:Immunoglobulin E