title: Synthesis and characterization of triethylene glycol dimethacrylate nanocapsules used in a self-healing bonding resin.
abstract: OBJECTIVE
  To date, the production of highly durable dentine bonding is still a challenge. Self-healing bonding resins may provide a new direction for the improvement of the bonding durability. The objective of the current study was to synthesize polyurethane nanocapsules encapsulated with the core material triethylene glycol dimethacrylate (TEGDMA) for use as a major component in a self-healing bonding resin.
  
  
  METHODS
  TEGDMA nanocapsules were synthesized via interfacial polycondensation in a miniemulsion, and the TEGDMA nanocapsules were then characterized via Fourier-transform infrared (FTIR) spectrometer, field emission scanning electron microscopy (FESEM), and high-performance liquid chromatography (HPLC) to investigate the morphology, the average TEGDMA loading (DL%), and encapsulation efficiency (EE%). The mechanical property of dental adhesive with different concentrations (0, 3, 6, 9, and 12 wt%) of the TEGDMA nanocapsules were also measured, and the cytotoxicity was investigated using an MTT assay.
  
  
  RESULTS
  FTIR confirmed that the TEGDMA nanocapsules were successfully synthesized. These nanocapsules showed a high drug load. The bond strength of the dental adhesive incorporated with 9 wt% TEGDMA nanocapsules was significantly higher compared with those of the other groups (P<0.001). Moreover, the biocompatibility of the dental adhesive was not affected by the incorporation of the TEGDMA nanocapsules.
  
  
  CONCLUSIONS
  The current study demonstrated the successful synthesis of TEGDMA nanocapsules, and the overall properties of the dental adhesive were not compromised.
authors.affiliation: The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan 430079, People's Republic of China.
authors.forename: Xiaobai
authors.initials: X
authors.lastname: Ouyang
authors.forename: Xueqing
authors.initials: X
authors.lastname: Huang
authors.forename: Qiuhua
authors.initials: Q
authors.lastname: Pan
authors.forename: Chenqi
authors.initials: C
authors.lastname: Zuo
authors.forename: Cui
authors.initials: C
authors.lastname: Huang
authors.forename: Xiangliang
authors.initials: X
authors.lastname: Yang
authors.forename: Yanbing
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D016475:3T3 Cells / Q000187:drug effects; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D002851:Chromatography, High Pressure Liquid; D004396:Coloring Agents; D003188:Composite Resins / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D001840:Dental Bonding; D003799:Dental Stress Analysis / Q000295:instrumentation; D003804:Dentin / Q000648:ultrastructure; D017220:Dentin-Bonding Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D008422:Materials Testing; D051379:Mice; D008855:Microscopy, Electron, Scanning; D053769:Nanocapsules / Q000737:chemistry* / Q000633:toxicity; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D011109:Polymethacrylic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D011140:Polyurethanes / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013314:Stress, Mechanical; D013718:Tensile Strength; D013778:Tetrazolium Salts; D013844:Thiazoles
chemical_list: D001672:Biocompatible Materials; C084111:Charisma composite resin; D004396:Coloring Agents; D003188:Composite Resins; D017220:Dentin-Bonding Agents; D053769:Nanocapsules; D011109:Polymethacrylic Acids; D011140:Polyurethanes; C425843:Prime and Bond NT; D013778:Tetrazolium Salts; D013844:Thiazoles; C020946:triethylene glycol dimethacrylate; D011092:Polyethylene Glycols; C022616:thiazolyl blue