title: [Peroxisomes--functions and disturbances in human metabolism].
abstract: Peroxisomes, classical compartments of eucaryotic cells have significant functions in cellular metabolism, which beta-oxidation fatty acids and detoxification of H2O2 are the most important biochemical process. Defects in genes encoding for peroxisomal proteins result in biochemical malfunctioning of these organelles and constitute base for severe human's inherited diseases. This article presents the most important aspects concerning peroxisomal biogenesis, biochemical functions and their disturbance.
authors.affiliation: Zaklad Biochemii i Medycyny Doświadczalnej, Instytut Pomnik-Centrum Zdrowia Dziecka, Warszawa. jstradomska@op.pl
authors.forename: Teresa J
authors.initials: TJ
authors.lastname: Stradomska
mesh_terms: D003066:Coenzyme A Ligases / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology; D018901:Peroxisomal Disorders / Q000378:metabolism*; D020675:Peroxisomes / Q000378:metabolism*; D000098859:Long-Chain-Fatty-Acid-CoA Ligase
chemical_list: D005227:Fatty Acids; D003066:Coenzyme A Ligases; D000098859:Long-Chain-Fatty-Acid-CoA Ligase