title: Astrotricoumarin, an antiproliferative 4'-hydroxy-2',3'-dihydroprenylated methylcoumarin from an Astrotrichilia sp. from the Madagascar dry forest.
abstract: Bioassay guided fractionation of the ethanol extract of a new endemic species of the genus Astrotrichilia led to the isolation of the new antiproliferative 3-(4'-hydroxy-2',3'-dihydroprenyl)-4,6-dimethoxy-5-methylcoumarin, named astrotricoumarin (8) with an IC50 value of 6.8 microM against the A2780 cell line. The structure of compound 8 was elucidated on the basis of its physical and spectroscopic data, including extensive 1D- and 2D-NMR analysis.
authors.affiliation: Department of Chemistry, M/C 0212, Virginia Tech, Blacksburg, VA 24061, USA.
authors.forename: Liva
authors.initials: L
authors.lastname: Harinantenaina
authors.forename: Peggy J
authors.initials: PJ
authors.lastname: Brodie
authors.forename: Martin W
authors.initials: MW
authors.lastname: Callmander
authors.forename: Richard
authors.initials: R
authors.lastname: Randrianaivo
authors.forename: Stephan
authors.initials: S
authors.lastname: Rakotonandrasana
authors.forename: Vincent E
authors.initials: VE
authors.lastname: Rasamison
authors.forename: Etienne
authors.initials: E
authors.lastname: Rakotobe
authors.forename: David G I
authors.initials: DG
authors.lastname: Kingston
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003374:Coumarins / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008270:Madagascar; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins; C562093:astrotricoumarin