title: Investigation of the unusual behavior of metolachlor under chemical ionization in a hybrid 3D ion trap mass spectrometer.
abstract: This article describes the strange behavior of the widely used herbicide metolachlor under chemical ionization conditions in a hybrid source ion trap mass spectrometer in gas chromatography/mass spectrometry (GC/MS) coupling. With the use of ammonia as the reagent gas, metolachlor provides a chlorinated ion at m/z 295/297, almost as abundant as the protonated molecule at m/z 284/286, which cannot be isolated to perform tandem mass spectrometry (MS(n)) experiments. Curiously, this ion at m/z = M + 12 is not observed for the herbicides acetochlor and alachlor, which present very similar chemical structures. The chemical structure of the m/z 295/297 ions and the explanation of the observed phenomenon based on the metastable behavior of these ions were elucidated on the basis of experiments including isotopic labeling and modifications of the operating conditions of the ion trap mass spectrometer. This work allows one to give new recommendations for an optimized use of hybrid source ion trap mass spectrometers.
authors.affiliation: Laboratoire des Mécanismes Réactionnels, Ecole Polytechnique, Route de Saclay, 91128 Palaiseau Cedex, France.
authors.forename: Pierre Henri
authors.initials: PH
authors.lastname: Goulden
authors.forename: Sarah
authors.initials: S
authors.lastname: Coffinet
authors.forename: Christophe
authors.initials: C
authors.lastname: Genty
authors.forename: Sophie
authors.initials: S
authors.lastname: Bourcier
authors.forename: Michel
authors.initials: M
authors.lastname: Sablier
authors.forename: Stéphane
authors.initials: S
authors.lastname: Bouchonnet
mesh_terms: D000081:Acetamides / Q000737:chemistry*; D000641:Ammonia / Q000737:chemistry; D008401:Gas Chromatography-Mass Spectrometry; D006540:Herbicides / Q000737:chemistry*; D007477:Ions / Q000737:chemistry
chemical_list: D000081:Acetamides; D006540:Herbicides; D007477:Ions; D000641:Ammonia; C051786:metolachlor