title: The extraction of aromatic carboxylic acids by the copper complex with Curtis macrocyclic tetramine and its utilization for photometric determination of nonsteroidal anti-inflammatory drugs.
abstract: Copper complex with Curtis macrocyclic tetramine is offered as reagent for extraction-photometric determination of nonsteroidal anti-inflammatory drugs (NSAIDs), belonging to the class of aromatic carboxylic acids. The studies indicate that this method is suitable for quantitative determination of NSAIDs, which have the constant distribution in the system chloroform/water (log P) no less than 3 and dissolubility in chloroform (S) no less than 10 mg/mL. Under optimum conditions, there are liner relationships between the absorption of chloroform extracts and concentration of NSAID in the range of 0.2-4 mg/mL for indometacin (Ind), 0.2-3 mg/mL for mefenamic acid (Mef) and 0.5-3 mg/mL for diclofenac (Dic). The detection limits (S/N = 3) of Ind, Mef and Dic are 0.2, 0.1 and 0.15 mg/mL, respectively. With the help of calculating method (SPARC V4.2) it was predicted the possibility of utilization of this method for extractive-photometric determination of its detached specimen NSAID.
authors.affiliation: A.V. Bogatsky Physico-chemical Institute of the National Academy of Sciences of Ukraine. 86, Lustdorfskaja doroga 65080, Odessa, Ukraine. zseltvay@mail.ru
authors.forename: Ivan
authors.initials: I
authors.lastname: Zseltvay
authors.forename: Olga
authors.initials: O
authors.lastname: Zheltvay
authors.forename: Valerij
authors.initials: V
authors.lastname: Antonovich
mesh_terms: D000465:Algorithms; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis*; D001952:Bridged-Ring Compounds / Q000737:chemistry*; D002264:Carboxylic Acids / Q000302:isolation & purification*; D003300:Copper / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D008970:Molecular Weight; D010783:Photometry; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets / Q000032:analysis
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001952:Bridged-Ring Compounds; D002264:Carboxylic Acids; D007202:Indicators and Reagents; D013607:Tablets; D003300:Copper; C010349:tetramethylenedisulfotetramine