title: An Image Driven Systems Biology Approach for Neurodegenerative Disease Studies in the TSC-mTOR Pathway.
abstract: In this brief paper we present an overview of the TSC-mTOR pathway and its importance in neurodegenerative disease (ND). We illustrate the influence of ND on dendritic spine morphology. Then we discuss some details of functional gene networks (FGN) and use this information to propose an image driven systems biology approach for the construction of a FGN for ND. We conclude on its importance and the prospective outcome of our study.
authors.affiliation: Center for Biotechnology and Informatics, The Methodist Hospital Research Institute and Department of Radiology, Weill Cornell Medical College, Houston, TX, 77030, U.S.A.
authors.forename: Dominik
authors.initials: D
authors.lastname: Beck
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Zhou
authors.forename: Tuan
authors.initials: T
authors.lastname: Pham
authors.forename: Bernardo
authors.initials: B
authors.lastname: Sabatini
authors.forename: Stephen T C
authors.initials: ST
authors.lastname: Wong