title: Role of topical nepafenac in prevention and treatment of macular edema after vitreoretinal surgery.
abstract: OBJECTIVE
  To evaluate the effects of topical nepafenac in patients undergoing vitreoretinal surgery.
  
  
  METHODS
  One hundred and twenty eyes of 120 patients undergoing vitreoretinal surgery were randomized to receive either topical nepafenac 0.1% (60 eyes) or placebo (60 eyes) in this investigator-masked, randomized, comparative case series. Eyes were evaluated for Day 1 postoperative inflammation and 2-, 4-, 6-, and 8-week postoperative retinal thickness and best-corrected visual acuity.
  
  
  RESULTS
  Mean Day 1 inflammation grades of 0.95 ± 0.6 and 1.78 ± 0.7 were noted in patients taking nepafenac and placebo, respectively (P = 0.002). The nepafenac and placebo groups had mean central macular subfield thickness of 228.44 ± 29.27 μm and 236.21 ± 29.44 μm at 4 weeks (P = 0.172) and 205.35 ± 25.25 μm and 205.37 ± 24.90 μm at 8 weeks (P = 0.971), respectively. At 1 month, there was no statistically significant difference in the mean visual acuity between the nepafenac group (0.55 ± 0.16 decimal units) and placebo group (0.52 ± 0.17 decimal units).
  
  
  CONCLUSIONS
  Topical nepafenac was safe and reduced postoperative pain and inflammation in patients undergoing vitreoretinal surgery. However, its effect on reducing postoperative macular edema and improving visual acuity as compared with that of the standard postvitrectomy therapeutic regimen was equivocal.
authors.affiliation: Dr. R. P. Center for Ophthalmic Sciences, AIIMS, New Delhi, India. drprashantnaithani@yahoo.co.in
authors.forename: Prashant
authors.initials: P
authors.lastname: Naithani
authors.forename: Shraddha
authors.initials: S
authors.lastname: Puranik
authors.forename: Naginder
authors.initials: N
authors.lastname: Vashisht
authors.forename: Sumeet
authors.initials: S
authors.lastname: Khanduja
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Kumar
authors.forename: Satpal
authors.initials: S
authors.lastname: Garg
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D044482:Benzeneacetamides / Q000008:administration & dosage*; D004311:Double-Blind Method; D058447:Eye Pain / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008269:Macular Edema / Q000503:physiopathology / Q000517:prevention & control*; D008297:Male; D010149:Postoperative Pain / Q000517:prevention & control*; D010648:Phenylacetates / Q000008:administration & dosage*; D014792:Visual Acuity / Q000502:physiology; D057586:Vitreoretinal Surgery
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D044482:Benzeneacetamides; D010648:Phenylacetates; C414203:nepafenac