title: The genetic basis of tooth agenesis: basic concepts and genes involved.
abstract: Tooth agenesis is the most prevalent craniofacial congenital malformation in humans. While tooth agenesis may be associated with several syndromes, non-syndromic hypodontia refers to the congenital absence of a few teeth in the absence of any other deformity. Recent advances in molecular genetics have made it possible to identify the exact genes responsible for the development of teeth and trace the mutations that cause hypodontia. This paper reviews the literature regarding the genetic basis of non-syndromic tooth agenesis, methods used to study it, and the genes that have been definitively implicated in the agenesis of human dentition.
authors.affiliation: Department of Pediatric Dentistry, Riyadh Colleges of Dentistry and Pharmacy, Riyadh, Saudi Arabia. sharatpani@hotmail.com
authors.forename: Sharat Chandra
authors.initials: SC
authors.lastname: Pani
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified / Q000235:genetics; D000848:Anodontia / Q000235:genetics*; D002874:Chromosome Mapping; D006801:Humans; D040582:Inheritance Patterns / Q000235:genetics; D051957:MSX1 Transcription Factor / Q000235:genetics; D051764:PAX9 Transcription Factor / Q000235:genetics
chemical_list: D051957:MSX1 Transcription Factor; C484083:MSX1 protein, human; D051764:PAX9 Transcription Factor; C497323:PAX9 protein, human