title: No evidence for statin-induced proteinuria in healthy volunteers as assessed by proteomic analysis.
abstract: In clinical studies of statins (class of drugs lowering plasma cholesterol levels), transient low-molecular-weight proteinuria was observed. The causes of statin-induced proteinuria in the patient background of those studies (cardiovascular and kidney disease) are multifactorial and, therefore, a matter of debate. In light of this, it seemed interesting to investigate the effect of statins on the urinary protein concentration and proteome in healthy volunteers. Six healthy volunteers were randomly treated with rosuvastatin (40 mg/day) or pravastatin (80 mg/day) in a double-blinded cross-over study. Total urinary protein concentration and the concentration of albumin/retinol-binding protein were analysed, after which the urinary proteome was investigated. From the results described in this study, it was concluded that statins do not induce major changes in the urinary protein concentration/proteome. High variability in the baseline urinary proteome/proteins among volunteers, however, made it very difficult to find subtle (possibly isolated to individuals) effects of statins.
authors.affiliation: Laboratory of Pathophysiology, University of Antwerp, Antwerpen, Belgium.
authors.forename: Anja
authors.initials: A
authors.lastname: Verhulst
authors.forename: Hilde
authors.initials: H
authors.lastname: Geryl
authors.forename: Patrick
authors.initials: P
authors.lastname: D'Haese
mesh_terms: D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000139:chemically induced / Q000652:urine; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005464:Fluorobenzenes / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D017035:Pravastatin / Q000008:administration & dosage / Q000009:adverse effects*; D011507:Proteinuria / Q000139:chemically induced* / Q000378:metabolism / Q000652:urine*; D020543:Proteome / Q000032:analysis*; D040901:Proteomics; D011743:Pyrimidines / Q000008:administration & dosage / Q000009:adverse effects*; D012177:Retinol-Binding Proteins / Q000652:urine; D000068718:Rosuvastatin Calcium; D013449:Sulfonamides / Q000008:administration & dosage / Q000009:adverse effects*; D057825:Two-Dimensional Difference Gel Electrophoresis
chemical_list: D005464:Fluorobenzenes; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D020543:Proteome; D011743:Pyrimidines; D012177:Retinol-Binding Proteins; D013449:Sulfonamides; D000068718:Rosuvastatin Calcium; D017035:Pravastatin