title: Transcription factor networks as targets for therapeutic intervention of cancer: the breast cancer paradigm.
abstract: It has long been shown that many of the presently used anticancer drugs exert their effects partly through modulating the activity of vital transcription factors. The intricacy of transcriptional regulation still represents the main obstacle for the design of transcription factor-directed agents. Systematic mapping of tumor-specific transcriptional networks and application of new molecular tools have reinforced research interest and efforts in this venue. The case of breast cancer is discussed as a representative example.
authors.affiliation: Molecular Oncology Unit, Department of Biological Chemistry, University of Athens Medical School, Athens, Greece.
authors.forename: Michalis V
authors.initials: MV
authors.lastname: Karamouzis
authors.forename: Athanasios G
authors.initials: AG
authors.lastname: Papavassiliou
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D005260:Female; D053263:Gene Regulatory Networks / Q000235:genetics*; D006801:Humans; D058990:Molecular Targeted Therapy; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014157:Transcription Factors