title: Transcriptional activators enhance polyadenylation of mRNA precursors.
abstract: 3' processing of mRNA precursors is frequently coupled to transcription by RNA polymerase II (RNAP II). This coupling is well known to involve the C-terminal domain of the RNAP II largest subunit, but a variety of other transcription-associated factors have also been suggested to mediate coupling. Our recent studies have provided direct evidence that transcriptional activators can enhance the efficiency of transcription-coupled 3' processing. In this point-of-view, we discuss the mechanisms that underlie coupling, and their implications for control of alternative polyadenylation, which is emerging as a significant regulator of cell growth control.
authors.affiliation: Department of Biological Sciences, Columbia University, New York, NY, USA. takashi.sugimoto@aist.go.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Nagaike
authors.forename: James L
authors.initials: JL
authors.lastname: Manley
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics; D000818:Animals; D006801:Humans; D008957:Models, Genetic; D011061:Poly A / Q000235:genetics; D026723:Polyadenylation; D012319:RNA Polymerase II / Q000378:metabolism; D012322:RNA Precursors / Q000235:genetics* / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D015534:Trans-Activators / Q000378:metabolism*; D014158:Transcription, Genetic; D015533:Transcriptional Activation
chemical_list: D020413:3' Untranslated Regions; D012322:RNA Precursors; D015534:Trans-Activators; D011061:Poly A; D012319:RNA Polymerase II; C410949:RNA polymerase II largest subunit