title: Coexistence of pregnancy-like and cystic hypersecretory hyperplasia with invasive lobular carcinoma.
abstract: BACKGROUND
  Lobular pregnancy-like hyperplasia (PLH) merged with cystic hypersecretory hyperplasia (CHH), designated PLH/CHH, is a rare multicystic breast lesion. A previous report has described the high rate of coexistent ductal carcinoma in situ in PLH/CHH; however, a PLH/CHH study involving a larger number of cases is necessary to unravel the clinical significance of this tumor type.
  
  
  METHODS
  We describe a unique case of PLH/CHH that coexisted with multifocal lobular neoplasm. Multifocal invasive lobular carcinoma with lobular carcinoma in situ was observed to be adjacent to the PLH/CHH cystic lesions in the left breast of a 70-year-old woman.
  
  
  CONCLUSIONS
  The present case documents the previously unreported coexistence of PLH/CHH accompanied by multifocal lobular carcinoma. Extensive examination, including an excisional biopsy, is prudent if a needle core biopsy reveals a PLH/CHH lesion.
authors.affiliation: Department of Pathology, Kochi Medical School, Nankoku, Japan.
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Takeuchi
authors.forename: Hideo
authors.initials: H
authors.lastname: Tsuzuki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Numoto
authors.forename: Mutsuo
authors.initials: M
authors.lastname: Furihata
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D001940:Breast / Q000473:pathology; D047688:Breast Cyst / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D002278:Carcinoma in Situ / Q000473:pathology / Q000601:surgery; D018275:Carcinoma, Lobular / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D006965:Hyperplasia; D015411:Mastectomy, Modified Radical; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000601:surgery; D016217:Ultrasonography, Mammary