title: Associations of serum brain-derived neurotrophic factor with cognitive impairments and negative symptoms in schizophrenia.
abstract: Brain-derived neurotrophic factor (BDNF) may be involved in the pathophysiology of schizophrenia. The aim of this study was to examine the associations of serum BDNF levels with the cognition and clinical characteristics in patients with schizophrenia. Sixty-three patients with schizophrenia and 52 age- and sex-matched healthy controls were examined with neuropsychological tests. Serum BDNF levels were determined by enzyme-linked immunosorbent assay (ELISA). There were no significant differences in serum BDNF levels between normal controls and patients with schizophrenia. Serum BDNF levels of normal controls showed negative correlations with verbal working memory, but this was not the case with schizophrenic patients. Meanwhile, serum BDNF levels of schizophrenic patients showed positive correlations with the scores of the Scale for the Assessment of Negative Symptoms (SANS) and the Information subtest scores of Wechsler Adult Intelligence Scale Revised (WAIS-R). Serum BDNF levels are related with the impairment of verbal working memory and negative symptoms in patients with schizophrenia.
authors.affiliation: Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan.
authors.forename: Tomihisa
authors.initials: T
authors.lastname: Niitsu
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Shirayama
authors.forename: Daisuke
authors.initials: D
authors.lastname: Matsuzawa
authors.forename: Tadashi
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Kanahara
authors.forename: Tasuku
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Shiraishi
authors.forename: Akihiro
authors.initials: A
authors.lastname: Shiina
authors.forename: Goro
authors.initials: G
authors.lastname: Fukami
authors.forename: Mihisa
authors.initials: M
authors.lastname: Fujisaki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Watanabe
authors.forename: Michiko
authors.initials: M
authors.lastname: Nakazato
authors.forename: Makoto
authors.initials: M
authors.lastname: Asano
authors.forename: Sho
authors.initials: S
authors.lastname: Kimura
authors.forename: Kenji
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Masaomi
authors.initials: M
authors.lastname: Iyo
mesh_terms: D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D003072:Cognition Disorders / Q000097:blood* / Q000150:complications / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D012559:Schizophrenia / Q000097:blood* / Q000150:complications; D012565:Schizophrenic Psychology
chemical_list: D019208:Brain-Derived Neurotrophic Factor