title: Adverse events over two years after retropubic or transobturator midurethral sling surgery: findings from the Trial of Midurethral Slings (TOMUS) study.
abstract: OBJECTIVE
  To describe surgical complications in 597 women over a 24-month period after randomization to retropubic or transobturator midurethral slings.
  
  
  METHODS
  During the Trial of Midurethral Slings study, the Data Safety Monitoring Board regularly reviewed summary reports of all adverse events using the Dindo Surgical Complication Scale. Logistic regression models were created to explore associations between clinicodemographic factors and surgical complications.
  
  
  RESULTS
  A total of 383 adverse events were observed among 253 of the 597 women (42%). Seventy-five adverse events (20%) were classified as serious (serious adverse events); occurring in 70 women. Intraoperative bladder perforation (15 events) occurred exclusively in the retropubic group. Neurologic adverse events were more common in the transobturator group than in retropubic (32 events vs 20 events, respectively). Twenty-three (4%) women experienced mesh complications, including delayed presentations, in both groups.
  
  
  CONCLUSIONS
  Adverse events vary by procedure, but are common after midurethral sling. Most events resolve without significant sequelae.
authors.affiliation: Department of Obstetrics and Gynecology, Stritch School of Medicine, Loyola University Chicago, Chicago, IL, USA.
authors.forename: Linda
authors.initials: L
authors.lastname: Brubaker
authors.forename: Peggy A
authors.initials: PA
authors.lastname: Norton
authors.forename: Michael E
authors.initials: ME
authors.lastname: Albo
authors.forename: Toby C
authors.initials: TC
authors.lastname: Chai
authors.forename: Kimberly J
authors.initials: KJ
authors.lastname: Dandreo
authors.forename: Keith L
authors.initials: KL
authors.lastname: Lloyd
authors.forename: Jerry L
authors.initials: JL
authors.lastname: Lowder
authors.forename: Larry T
authors.initials: LT
authors.lastname: Sirls
authors.forename: Gary E
authors.initials: GE
authors.lastname: Lemack
authors.forename: Amy M
authors.initials: AM
authors.lastname: Arisco
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
authors.forename: John W
authors.initials: JW
authors.lastname: Kusek
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D011183:Postoperative Complications / Q000209:etiology*; D053825:Suburethral Slings / Q000009:adverse effects*; D016896:Treatment Outcome; D001745:Urinary Bladder Diseases / Q000209:etiology*; D014550:Urinary Incontinence, Stress / Q000601:surgery*; D013520:Urologic Surgical Procedures / Q000009:adverse effects