title: The effect of corrective surgery on serum IGF-1, IGFBP-3 levels and growth in children with congenital heart disease.
abstract: The aim of this study is to evaluate growth and insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 3 (IGFBP-3) levels in infants with congenital heart disease (CHD) pre- and postoperatively over a period of a year. Anthropometric values and serum levels of IGF-1 and IGFBP-3 of 40 infants with CHD (20 cyanotic and 20 acyanotic) were compared with 32 healthy controls. Acyanotic infants and infants with pulmonary hypertension (PH) presented significantly more growth failure. Preoperatively, serum IGF-1 and IGFBP-3 levels were lower in the acyanotic group than the cyanotic and the control groups (p = 0.22; p < 0.01). The upward trend in IGF-1 and IGFBP-3 levels in this year-long study demonstrated that the values in the third month and the first year were higher than the preoperative values (p < 0.05). The parallel increase of weight gain and IGF-1, IGFBP-3 levels were the best evidence that these parameters are good nutritional indicators. Timing the corrective surgery before chronic malnutrition or PH develops is an important issue to maintain a normal growth for children with CHD.
authors.affiliation: Department of Pediatrics, Baskent University Faculty of Medicine, Ankara, Turkey. ozgesur@yahoo.com
authors.forename: Ozge
authors.initials: O
authors.lastname: Surmeli-Onay
authors.forename: Nimet
authors.initials: N
authors.lastname: Cindik
authors.forename: Sibel Tulgar
authors.initials: ST
authors.lastname: Kinik
authors.forename: Suleyman
authors.initials: S
authors.lastname: Ozkan
authors.forename: Nilufer
authors.initials: N
authors.lastname: Bayraktar
authors.forename: Kursad
authors.initials: K
authors.lastname: Tokel
mesh_terms: D002657:Child Development; D003490:Cyanosis / Q000209:etiology; D006128:Growth; D006130:Growth Disorders / Q000209:etiology / Q000517:prevention & control*; D006330:Heart Defects, Congenital / Q000097:blood* / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology; D007223:Infant; D007228:Infant Nutrition Disorders / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D007231:Infant, Newborn; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D009752:Nutritional Status; D015995:Prevalence; D011446:Prospective Studies; D012720:Severity of Illness Index; D013997:Time Factors; D014421:Turkey / Q000453:epidemiology
chemical_list: C515497:IGFBP3 protein, human; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I