title: Matched-pair analysis and dosimetric variations of two types of software for interstitial permanent brachytherapy for prostate cancer.
abstract: The purpose of this study was to determine whether identical dosimetric results could be achieved using different planning software for permanent interstitial brachytherapy for prostate cancer. Data from 492 patients treated with brachytherapy were used for matched-pair analysis. Interplant and Variseed were used as software for ultrasound-based treatment planning. Institution, neoadjuvant hormonal therapy, prostate volume, and source strength were used for factors to match the 2 groups. The study population comprised of 126 patients with treatment planning using Interplant software and 127 matched patients using Variseed software. Dosimetric results were compared between the 2 groups. The Variseed group showed significantly higher values for dose covering 90% of prostate volume (pD90), prostate volume covered by 150% of prescription dose (pV150), and dose covering 30% of the urethra (uD30) compared with the Interplant group. Our results showed that use of different software could lead to different dosimetric results, which might affect the clinical outcomes.
authors.affiliation: Department of Radiology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan. hishiyam@kitasato-u.ac.jp
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Ishiyama
authors.forename: Ryuji
authors.initials: R
authors.lastname: Nakamura
authors.forename: Takefumi
authors.initials: T
authors.lastname: Satoh
authors.forename: Susumu
authors.initials: S
authors.lastname: Tanji
authors.forename: Bin S
authors.initials: BS
authors.lastname: Teh
authors.forename: Mineko
authors.initials: M
authors.lastname: Uemae
authors.forename: Shiro
authors.initials: S
authors.lastname: Baba
authors.forename: Kazushige
authors.initials: K
authors.lastname: Hayakawa
mesh_terms: D001918:Brachytherapy / Q000379:methods*; D006801:Humans; D016555:Matched-Pair Analysis; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012984:Software; D012986:Software Validation