title: Natural course of cow's milk allergy in children with atopic dermatitis.
abstract: Cow's milk is one of the most common food allergens in children with atopic dermatitis (AD). This study was conducted to describe the natural course of cow's milk allergy in children with AD, and to identify factors predictive of outcome. To accomplish this, we reviewed the medical records of 115 children who were diagnosed with AD and cow's milk allergy before 24 months of age to evaluate their clinical characteristics and prognostic factors. During a follow-up period of 24 to 114 months, the median age for tolerance to cow's milk was found to be 67 months. Multivariate analysis using the Cox proportional hazard model revealed that the peak cow's milk-specific IgE level within 24 months after birth was the most important factor for prediction of the outcome of cow's milk allergy. In conclusion, half of the children younger than 24 months of age with AD and cow's milk allergy could tolerate cow's milk at 67 months of age. The peak cow's milk-specific IgE level within the first 24 months of birth is useful to predict the prognosis of cow's milk allergy in children with AD.
authors.affiliation: Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Environmental Health Center for Atopic Diseases, Seoul, Korea.
authors.forename: Jungmin
authors.initials: J
authors.lastname: Suh
authors.forename: Hyeonyoung
authors.initials: H
authors.lastname: Lee
authors.forename: Jung Hyun
authors.initials: JH
authors.lastname: Lee
authors.forename: Joongbum
authors.initials: J
authors.lastname: Cho
authors.forename: Jung-Seok
authors.initials: JS
authors.lastname: Yu
authors.forename: Jihyun
authors.initials: J
authors.lastname: Kim
authors.forename: Youngshin
authors.initials: Y
authors.lastname: Han
authors.forename: Kangmo
authors.initials: K
authors.lastname: Ahn
authors.forename: Sang-Il
authors.initials: SI
authors.lastname: Lee
mesh_terms: D000818:Animals; D002417:Cattle; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000150:complications / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007108:Immune Tolerance; D007073:Immunoglobulin E / Q000097:blood; D007223:Infant; D008297:Male; D008892:Milk / Q000276:immunology; D016269:Milk Hypersensitivity / Q000150:complications / Q000175:diagnosis*; D016017:Odds Ratio; D011379:Prognosis; D013997:Time Factors
chemical_list: D007073:Immunoglobulin E