title: Neurofilamentopathy in neurodegenerative diseases.
abstract: Neurofilament protein alterations are found in many neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson, Alzheimer, and Charcot-Marie-Tooth. Abnormal modifications of neurofilament, such as mutation, oxidation and phosphorylation, are linked to the disease-related alteration. In this review, the most recent discovery and central arguments about functions, pathological modifications, and genetic mutations related to neurofilaments in neurodegenerative diseases is presented.
authors.affiliation: School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Quan
authors.initials: Q
authors.lastname: Liu
authors.forename: Fang
authors.initials: F
authors.lastname: Xie
authors.forename: Abdiel
authors.initials: A
authors.lastname: Alvarado-Diaz
authors.forename: Mark A
authors.initials: MA
authors.lastname: Smith
authors.forename: Paula I
authors.initials: PI
authors.lastname: Moreira
authors.forename: Xiongwei
authors.initials: X
authors.lastname: Zhu
authors.forename: George
authors.initials: G
authors.lastname: Perry