title: [Bronchiolitis obliterans postallogeneic stem cell transplantation: what is new?].
abstract: Bronchiolitis obliterans (BO) is a severe complication of hematopoietic stem cell transplantation (HSCT). It is considered as a respiratory manifestation of chronic graft-versus-host disease. It is quite similar to the bronchiolitis obliterans after lung transplantation. Classical therapy associates steroids and immunosuppressive drugs, however theses procedure showed a modest efficacy and have an important morbidity. Recent progresses in the physiopathology of BO post-HSCT allow to use new treatments: mTOR inhibitors, immunotherapy, extra-corporeal photochemotherapy, and bronchial anti-inflammatory effects of azithromycin, statins or antileucotriens. This review will focus on the use of these new therapies in BO post-HSCT.
authors.affiliation: Service dePneumologie, Hôpital Foch, 40, rue Worth, 92150 Suresnes, France. francislem@hotmail.com
authors.forename: F
authors.initials: F
authors.lastname: Lemonnier
authors.forename: N
authors.initials: N
authors.lastname: Dhedin
authors.forename: E
authors.initials: E
authors.lastname: Catherinot
authors.forename: C
authors.initials: C
authors.lastname: Tcherakian
authors.forename: H
authors.initials: H
authors.lastname: Neveu
authors.forename: F
authors.initials: F
authors.lastname: Suarez
authors.forename: M-H
authors.initials: MH
authors.lastname: Becquemin
authors.forename: P
authors.initials: P
authors.lastname: Devillier
authors.forename: J-P
authors.initials: JP
authors.lastname: Vernant
authors.forename: L-J
authors.initials: LJ
authors.lastname: Couderc
authors.forename: E
authors.initials: E
authors.lastname: Rivaud
mesh_terms: D001989:Bronchiolitis Obliterans / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D012307:Risk Factors