title: Plasma soluble urokinase plasminogen activator receptor in children with urinary tract infection.
abstract: OBJECTIVE
  In this prospective study we investigated the role of plasma levels of soluble urokinase plasminogen activator receptor (suPAR) in children with urinary tract infection.
  
  
  METHODS
  We measured the levels of plasma suPAR during admission in 42 children with suspected acute pyelonephritis and compared the results to acute DMSA scintigraphy.
  
  
  RESULTS
  The mean level of plasma suPAR at admission was significantly elevated in children with renal involvement (7.3 ng/ml) assessed by the DMSA scintigraphy compared to children without renal involvement (4.4 ng/ml, P = 0.010). The positive predictive value of suPAR seems high, since all patients without renal involvement had low suPAR values. During treatment the mean level of plasma suPAR decreased.
  
  
  CONCLUSIONS
  We conclude that plasma suPAR could be of clinical use for the diagnosis of acute pyelonephritis and that high levels of plasma suPAR might reflect the level of renal involvement and could therefore be a new indicator for renal scarring.
authors.affiliation: Clinical Research Centre, Copenhagen University, Hvidovre Hospital, Denmark.
authors.forename: Per
authors.initials: P
authors.lastname: Wittenhagen
authors.forename: Jesper Brandt
authors.initials: JB
authors.lastname: Andersen
authors.forename: Anita
authors.initials: A
authors.lastname: Hansen
authors.forename: Lone
authors.initials: L
authors.lastname: Lindholm
authors.forename: Frederik
authors.initials: F
authors.lastname: Rønne
authors.forename: Jørn
authors.initials: J
authors.lastname: Theil
authors.forename: Michael
authors.initials: M
authors.lastname: Tvede
authors.forename: Jesper
authors.initials: J
authors.lastname: Eugen-Olsen