title: Detection of familial adenomatous polyposis with orthogonal polarized spectroscopy of the oral mucosa vasculature.
abstract: Familial Adenomatous Polyposis (FAP) is an autosomal dominant disease characterized by the development of multiple colonic polyps at younger age with a near 100% lifetime risk of colorectal cancer. The determination of FAP is made after extensive clinical evaluation and genetic testing of at risk individuals. We investigated a novel spectro-polarimetric imaging system capable of capturing high-resolution images of the oral mucosa at different wavelengths in an attempt to distinguish patients with FAP from controls. Results of a clinical trial show that the system is capable of separating FAP positive individuals from controls by measuring the individuals' oral vascular density and complexity.
authors.affiliation: The Catholic University of America, 620 Michigan Ave NE, Washington, DC, USA. 13basiri@cardinalmail.cua.edu
authors.forename: Ali
authors.initials: A
authors.lastname: Basiri
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Edelstein
authors.forename: Jenna
authors.initials: J
authors.lastname: Graham
authors.forename: Afshin
authors.initials: A
authors.lastname: Nabili
authors.forename: Francis M
authors.initials: FM
authors.lastname: Giardiello
authors.forename: Jessica C
authors.initials: JC
authors.lastname: Ramella-Roman
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000175:diagnosis* / Q000235:genetics; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D007834:Lasers; D008027:Light; D008297:Male; D009061:Mouth Mucosa / Q000098:blood supply / Q000473:pathology*; D010375:Pedigree; D012031:Refractometry / Q000295:instrumentation / Q000379:methods; D012307:Risk Factors; D013057:Spectrum Analysis / Q000295:instrumentation / Q000379:methods*