title: The ratio of adiponectin to HOMA as an index of metabolic syndrome in obese women.
abstract: OBJECTIVE
  The aim of our study was to investigate the role of the ratio of adiponectin concentration to homeostasis model assessment insulin resistance (HOMA-IR) as a predictor of metabolic syndrome (MS) in obese subjects.
  
  
  METHODS
  We studied a population-based cross-sectional sample of 217 obese women. To estimate the prevalence of MS, the definitions of the Adult Treatment Panel III (ATP III) were considered.
  
  
  RESULTS
  The area under the curve (AUC) of the receiver-operating characteristic (ROC) curve for the detection of each MS component on the basis of the ratio of the serum adiponectin concentration to HOMA-IR (A/H ratio) was higher than that for the detection based on serum adiponectin concentration (for central obesity: 0.722 vs. 0.316, for increased triglycerides: 0.579 vs. 0.500, for increased blood pressure: 0.573 vs. 0.493, and for elevated fasting plasma glucose: 0.718 vs. 0.465). The AUC of the ROC curve for the detection of MS on the basis of the A/H ratio was higher than that for the detection based on serum adiponectin concentration (0.700 vs. 0.481).
  
  
  CONCLUSIONS
  The A/H ratio appears to provide a discriminatory marker for MS risk and some components of MS (central obesity, increased blood pressure and elevated fasting plasma glucose) in obese women.
authors.affiliation: Center of Investigation of Endocrinology and Clinical Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain. dadluis@yahoo.es
authors.forename: Daniel Antonio
authors.initials: DA
authors.lastname: de Luis
authors.forename: Rocio
authors.initials: R
authors.lastname: Aller
authors.forename: Olatz
authors.initials: O
authors.lastname: Izaola
authors.forename: Rosa
authors.initials: R
authors.lastname: Conde
authors.forename: Manuel
authors.initials: M
authors.lastname: Gonzalez Sagrado
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D000465:Algorithms; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D006306:Health Surveys; D006801:Humans; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000378:metabolism* / Q000503:physiopathology; D056128:Obesity, Abdominal / Q000097:blood / Q000378:metabolism / Q000503:physiopathology; D050177:Overweight / Q000097:blood / Q000378:metabolism / Q000503:physiopathology; D015995:Prevalence; D012306:Risk; D012720:Severity of Illness Index; D013030:Spain / Q000453:epidemiology
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers