title: Left ventricular mechanical synchrony from stress and rest 82Rb PET myocardial perfusion ECG-gated studies: differentiating normal from LBBB patients.
abstract: BACKGROUND
  We have previously reported normal values for LV mechanical synchrony from post-stress exercise (99m)Tc SPECT studies; the goal of this study was to develop normal values for mechanical synchrony from pharmacologic stress and rest (82)Rb PET studies and compare these values to a population of LBBB patients.
  
  
  RESULTS
  The normal population consisted of 40 patients with a low likelihood of coronary artery disease. The LBBB population consisted of 23 patients with ECG evidence of LBBB. All patients were imaged with pharmacologic stress and processed using SyncTool™ (Emory Cardiac Toolbox™). Means and standard deviations were calculated for the stress and rest phase parameters. Normal male and female phase standard deviation were 15.0 ± 7.0 and 13.2 ± 7.7, respectively, for stress (P = NS), and 22.7 ± 13.2 and 16.6 ± 14.3 for rest (P = NS). Normal male and female histogram bandwidth were 38.1 ± 13.3 and 32.0 ± 13.5, respectively, for stress (P = NS) and 50.8 ± 18.7 and 44.4 ± 44.9 for rest (P = NS). ROC analysis yielded a sensitivity/specificity as high as 80%/90% for males, and 92%/75% for females (P = NS).
  
  
  CONCLUSIONS
  Normal values for LV mechanical synchrony have been developed for (82)Rb pharmacologic stress and rest PET studies; furthermore, the stress pharmacologic values do not differ significantly from our previously reported exercise post-stress SPECT normal values. Finally, ROC analysis confirmed that these normal values were able to differentiate normal and LBBB populations.
authors.affiliation: Department of Radiology, Emory University School of Medicine, 1364 Clifton Rd NE, Atlanta, GA 30322, USA. ccooke@emory.edu
authors.forename: C David
authors.initials: CD
authors.lastname: Cooke
authors.forename: Fabio P
authors.initials: FP
authors.lastname: Esteves
authors.forename: Ji
authors.initials: J
authors.lastname: Chen
authors.forename: Ernest V
authors.initials: EV
authors.lastname: Garcia
mesh_terms: D000368:Aged; D002037:Bundle-Branch Block / Q000175:diagnosis*; D055424:Cardiac-Gated Imaging Techniques / Q000379:methods*; D003937:Diagnosis, Differential; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D012016:Reference Values; D015203:Reproducibility of Results; D012414:Rubidium Radioisotopes; D012680:Sensitivity and Specificity; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis*
chemical_list: D019275:Radiopharmaceuticals; D012414:Rubidium Radioisotopes