title: Novel roles for TIM-1 in immunity and infection.
abstract: T cell, immunoglobulin domain and mucin domain-1 (TIM-1) is the nominant member of a small family of related proteins that regulate immune cell activities. TIM-1 was initially characterized in a mouse congenic analysis of Th2 T cell responses and related pathology. Data accumulated to date suggest that TIM-1 regulates effector T cell function, and may play distinct roles in the activities of B cells, invariant NKT cells and epithelial cells. In addition, a variety of ligands for TIM-1 have been proposed. In this review I discuss recent data that have accumulated on the function of TIM-1, propose a model to explain how TIM-1 regulates effector T cell activity through recognition of distinct ligands, and review others functions of this increasingly fascinating protein. Of considerable interest are the novel findings that TIM-1 mediates virus entry and virulence.
authors.affiliation: Department of Molecular Discovery and Immunobiology, Biogen Idec Inc., Cambridge, MA 02142, United States. paul.rennert@biogenidec.com
authors.forename: Paul D
authors.initials: PD
authors.lastname: Rennert
mesh_terms: D000818:Animals; D001249:Asthma / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology; D016563:Filoviridae / Q000378:metabolism; D000072596:Hepatitis A Virus Cellular Receptor 1; D030041:Hepatitis A virus / Q000378:metabolism; D006801:Humans; D061148:Hygiene Hypothesis; D007239:Infections / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D008562:Membrane Glycoproteins / Q000276:immunology / Q000378:metabolism; D008565:Membrane Proteins / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011485:Protein Binding / Q000276:immunology; D020033:Protein Isoforms; D011971:Receptors, Immunologic / Q000378:metabolism*; D011991:Receptors, Virus / Q000276:immunology / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism
chemical_list: C491143:HAVCR1 protein, human; C442240:Havcr1 protein, mouse; D000072596:Hepatitis A Virus Cellular Receptor 1; C527073:LMIR5 protein, mouse; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D020033:Protein Isoforms; D011971:Receptors, Immunologic; D011991:Receptors, Virus