title: Chemoprevention of breast cancer by fish oil in preclinical models: trials and tribulations.
abstract: Despite the perception that omega-3 fatty acids (n-3 FA) protect against breast cancer, epidemiologic studies have yielded inconsistent results. Although preclinical data have been, in general, more supportive of a protective effect of n-3 FA on breast cancer, inconsistencies still remain, which preclude definite conclusions or in-depth mechanistic investigations despite 30 years of research in this area. In this review, we discuss key variables that may account for inconsistencies of results across preclinical studies and provide recommendations for future experiments testing the chemopreventive effect of n-3 FAs in breast cancer, as part of a multiagent approach under rigorously controlled conditions.
authors.affiliation: Department of Medicine, Penn State University College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.
authors.forename: Carina
authors.initials: C
authors.lastname: Signori
authors.forename: Karam
authors.initials: K
authors.lastname: El-Bayoumy
authors.forename: Jose
authors.initials: J
authors.lastname: Russo
authors.forename: Henry J
authors.initials: HJ
authors.lastname: Thompson
authors.forename: John P
authors.initials: JP
authors.lastname: Richie
authors.forename: Terryl J
authors.initials: TJ
authors.lastname: Hartman
authors.forename: Andrea
authors.initials: A
authors.lastname: Manni
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology / Q000517:prevention & control*; D018890:Chemoprevention; D004032:Diet; D004353:Drug Evaluation, Preclinical / Q000592:standards / Q000639:trends; D004347:Drug Interactions; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006801:Humans
chemical_list: D000970:Antineoplastic Agents; D015525:Fatty Acids, Omega-3