title: Successful pregnancy with epidermal growth factor receptor tyrosine kinase inhibitor treatment of metastatic lung adenocarcinoma presenting with respiratory failure.
abstract: We report a woman presenting with respiratory failure due to a right-sided pleural effusion, lung metastases and lymphangitis carcinomatosis from advanced lung adenocarcinoma in the third trimester of pregnancy, who showed good response to EGFR tyrosine kinase inhibitor.
authors.affiliation: Division of Respiratory Medicine, Department of Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. ipohchlee@yahoo.com
authors.forename: Chee-Hong
authors.initials: CH
authors.lastname: Lee
authors.forename: Chong-Kin
authors.initials: CK
authors.lastname: Liam
authors.forename: Yong-Kek
authors.initials: YK
authors.lastname: Pang
authors.forename: Keong-Tiong
authors.initials: KT
authors.lastname: Chua
authors.forename: Boon-Khaw
authors.initials: BK
authors.lastname: Lim
authors.forename: Nai-Lang
authors.initials: NL
authors.lastname: Lai
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology / Q000556:secondary; D000328:Adult; D018450:Disease Progression; D066246:ErbB Receptors / Q000037:antagonists & inhibitors / Q000235:genetics; D000069347:Erlotinib Hydrochloride; D005260:Female; D000077156:Gefitinib; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D008205:Lymphangitis; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D016066:Pleural Effusion, Malignant; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D011263:Pregnancy Trimester, Third; D011799:Quinazolines / Q000008:administration & dosage* / Q000494:pharmacology; D012074:Remission Induction; D012131:Respiratory Insufficiency; D017384:Sequence Deletion / Q000235:genetics; D047929:Term Birth
chemical_list: D011799:Quinazolines; D000069347:Erlotinib Hydrochloride; D066246:ErbB Receptors; D000077156:Gefitinib