title: A new pyrrolidine derivative and steroids from an algicolous Gibberella zeae strain.
abstract: A new pyrrolidine derivative, 3-hydroxy-5-(hydroxymethyl)-4-(4'-hydroxyphenoxy)pyrrolidin-2-one (1), and eight known steroids, (22E,24R)-7beta,8beta-epoxy-3beta,5alpha,9alpha-trihydroxyergosta-22-en-6-one (2, a reassigned structure of (22E,24R)-5alpha,6alpha-epoxy-3beta,8beta,14alpha-trihydroxyergosta-22-en-7-one), (22E,24R)-3beta,5alpha,9alpha-trihydroxyergosta-7,22-dien-6-one (3), (22E,24R)-3beta,5alpha-dihydroxyergosta-7,22-dien-6-one (4), (22E,24R)-ergosta-7,22-dien-3beta/,5alpha,6beta-triol (5), (22E,24R)-ergosta-5,22-dien-3beta-ol (6), (22E,24R)-5alpha,8alpha-epidioxyergosta-6,22-dien-3beta-ol (7), (22E,24R)-5alpha,8alpha-epidioxyergosta-6,9(11),22-trien-3beta-ol (8), and (22E,24R)-1(10 --> 6)-abeo-ergosta-5,7,9,22-tetraen-3alpha-ol (9), were isolated from the cultures of Gibberella zeae, an endophytic fungus isolated from the marine green alga Codium fragile. Their structures and relative stereochemistry were elucidated by 1D, 2D NMR and mass spectroscopic techniques. Compound 1 showed cytotoxicity against A-549 and BEL-7402 cell lines.
authors.affiliation: College of Food Science and Engineering, Shandong Agricultural University, Taian 271018, China.
authors.forename: Xiang-Hong
authors.initials: XH
authors.lastname: Liu
authors.forename: Xiao-Zhen
authors.initials: XZ
authors.lastname: Tang
authors.forename: Feng-Ping
authors.initials: FP
authors.lastname: Miao
authors.forename: Nai-Yun
authors.initials: NY
authors.lastname: Ji
mesh_terms: D000460:Chlorophyta / Q000737:chemistry; D005874:Gibberella / Q000737:chemistry*; D015394:Molecular Structure; D011759:Pyrrolidines / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry*
chemical_list: D011759:Pyrrolidines; D013256:Steroids