title: A single phosphine ligand allows palladium-catalyzed intermolecular C-O bond formation with secondary and primary alcohols.
abstract: Forging a bond: an efficient, general palladium catalyst for C-O bond-forming reactions of secondary and primary alcohols with a range of aryl halides has been developed using the ligand 1. Heteroaryl halides, and for the first time, electron-rich aryl halides can be coupled with secondary alcohols. A diverse set of substrate combinations are possible with just a single ligand, thus obviating the need to survey multiple ligands.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, 02139, USA.
authors.forename: Xiaoxing
authors.initials: X
authors.lastname: Wu
authors.forename: Brett P
authors.initials: BP
authors.lastname: Fors
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Buchwald
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D002384:Catalysis; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*
chemical_list: D000438:Alcohols; D006842:Hydrocarbons, Brominated; D008024:Ligands; D009942:Organometallic Compounds; D010720:Phosphines; D010165:Palladium; C044646:phosphine