title: Coordinating cell polarity with cell division in space and time.
abstract: Decisions of when and where to divide are crucial for cell survival and fate, and for tissue organization and homeostasis. The temporal coordination of mitotic events during cell division is essential to ensure that each daughter cell receives one copy of the genome. The spatial coordination of these events is also crucial because the cytokinetic furrow must be aligned with the axis of chromosome segregation and, in asymmetrically dividing cells, the polarity axis. Several recent papers describe how cell shape and polarity are coordinated with cell division in single cells and tissues and begin to unravel the underlying molecular mechanisms, revealing common principles and molecular players. Here, we discuss how cells regulate the spatial and temporal coordination of cell polarity with cell division.
authors.affiliation: Department of Genetic Medicine and Development, Faculty of Medicine, University of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland.
authors.forename: Costanza
authors.initials: C
authors.lastname: Panbianco
authors.forename: Monica
authors.initials: M
authors.lastname: Gotta
mesh_terms: D000818:Animals; D059447:Cell Cycle Checkpoints; D018797:Cell Cycle Proteins / Q000378:metabolism; D002455:Cell Division; D016764:Cell Polarity; D048430:Cell Shape; D006801:Humans; D015003:Yeasts / Q000166:cytology / Q000502:physiology
chemical_list: D018797:Cell Cycle Proteins