title: Combination self-assembly of β-sheet peptides and carbon nanotubes: functionalizing carbon nanotubes with bioactive β-sheet block copolypeptides.
abstract: Understanding the self-assembly behavior of β-sheet peptides is important, not only in constructing bioactive peptide nanostructures, but also in inhibiting uncontrollable protein aggregation in protein-misfolding diseases. Here, the first systematic investigation of combination self-assembly between β-sheet block copolypeptides and CNTs is presented, demonstrating the presence of several different association modes during the combination self-assembly process. Bioactive β-sheet block copolypeptides can self-assemble by themselves, or can be used to functionalize CNT hybrids depending on the situation. This behavior may be important both for fabricating bioactive peptide/CNT hybrids and for controlling/inhibiting protein-misfolding diseases.
authors.affiliation: Translational Research Center for Protein Function Control & Department of Materials Science and Engineering, Yonsei University, Seoul, Korea.
authors.forename: Woo-jin
authors.initials: WJ
authors.lastname: Jeong
authors.forename: Yong-beom
authors.initials: YB
authors.lastname: Lim
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D002942:Circular Dichroism / Q000379:methods; D006367:HeLa Cells / Q000378:metabolism; D006801:Humans; D046529:Microscopy, Electron, Transmission / Q000379:methods; D008958:Models, Molecular; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D009994:Osmolar Concentration; D010455:Peptides / Q000737:chemistry*; D017433:Protein Structure, Secondary; D013050:Spectrometry, Fluorescence / Q000379:methods; D014407:Tumor Cells, Cultured
chemical_list: D001672:Biocompatible Materials; D037742:Nanotubes, Carbon; D010455:Peptides