title: Synthetic polymers for simultaneous bacterial sequestration and quorum sense interference.
abstract: Double agents: dual-action polymers are able to sequester rapidly the marine organism Vibrio harveyi from suspension, while at the same time quenching bacterial quorum sense (QS) signals. The potency of the polymers is assessed by cell aggregation experiments and competitive binding assays against a QS signal precursor, and their effect on bacterial behavior is shown by means of bioluminescence.
authors.affiliation: School of Pharmacy, The University of Nottingham, University Park, UK.
authors.forename: Xuan
authors.initials: X
authors.lastname: Xue
authors.forename: George
authors.initials: G
authors.lastname: Pasparakis
authors.forename: Nigel
authors.initials: N
authors.lastname: Halliday
authors.forename: Klaus
authors.initials: K
authors.lastname: Winzer
authors.forename: Steven M
authors.initials: SM
authors.lastname: Howdle
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Cramphorn
authors.forename: Neil R
authors.initials: NR
authors.lastname: Cameron
authors.forename: Paul M
authors.initials: PM
authors.lastname: Gardner
authors.forename: Benjamin G
authors.initials: BG
authors.lastname: Davis
authors.forename: Francisco
authors.initials: F
authors.lastname: Fernández-Trillo
authors.forename: Cameron
authors.initials: C
authors.lastname: Alexander
mesh_terms: D002448:Cell Adhesion / Q000187:drug effects; D015394:Molecular Structure; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D053038:Quorum Sensing / Q000187:drug effects*; D013045:Species Specificity; D013329:Structure-Activity Relationship; D013499:Surface Properties; D014733:Vibrio / Q000166:cytology / Q000187:drug effects*
chemical_list: D011108:Polymers