title: [Genotypic resistance mutations to antiretroviral drugs in newly confirmed human immunodeficiency virus infectors in Beijing].
abstract: OBJECTIVE
  To examine the prevalence of drug resistance mutations among the treatment-naive HIV (human immunodeficiency virus) infectors living in Beijing so as to provide the basal information for clinical antiviral treatment.
  
  
  METHODS
  HIV pol genes from plasma samples of 150 treatment-naive HIV-infected patients were amplified, sequenced and phylogenetically analyzed. And the drug-resistance associated mutations in protease and reverse transcriptase regions were analyzed with Stanford University HIV Drug Resistance Database.
  
  
  RESULTS
  A total of 111 pol gene sequences were obtained. The overall prevalence of drug resistance was 8.1% (9/111), corresponding to 3.6% (4/111) for protease inhibitors, 1.8% (2/111) for nucleoside reverse transcriptase inhibitors and 3.6% (4/111) for non-nucleoside reverse transcriptase inhibitors. No drug resistance mutation was identified in 17 intravenous drug users.
  
  
  CONCLUSIONS
  The prevalence of drug resistance is relatively high in the newly confirmed HIV infectors in Beijing. Regular surveillance and monitoring of drug-resistant HIV should be implemented.
authors.affiliation: National Institute for Viral Disease Control & Prevention, China CDC, Beijing 100052, China. basketball197602@hotmail.com
authors.forename: Jing-rong
authors.initials: JR
authors.lastname: Ye
authors.forename: Lei
authors.initials: L
authors.lastname: Guo
authors.forename: Hong-yan
authors.initials: HY
authors.lastname: Lu
authors.forename: Ruo-lei
authors.initials: RL
authors.lastname: Xin
authors.forename: Yi
authors.initials: Y
authors.lastname: Zeng
mesh_terms: D000293:Adolescent; D000328:Adult; D019380:Anti-HIV Agents / Q000494:pharmacology*; D002681:China / Q000453:epidemiology; D024882:Drug Resistance, Viral; D005260:Female; D015658:HIV Infections / Q000453:epidemiology / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D012367:RNA, Viral / Q000235:genetics; D055815:Young Adult; D054302:pol Gene Products, Human Immunodeficiency Virus / Q000235:genetics
chemical_list: D019380:Anti-HIV Agents; D012367:RNA, Viral; D054302:pol Gene Products, Human Immunodeficiency Virus