title: Double arylation of allyl alcohol via a one-pot Heck arylation-isomerization-acylation cascade.
abstract: A one-pot, two-step catalytic protocol has been developed. A regioselective Heck coupling between aryl bromides and allyl alcohol leads to the generation of arylated allyl alcohols that in situ isomerize to give aldehydes, which then undergo an acylation reaction with a second aryl bromide. A variety of aryl bromides can be employed in both the initial Heck reaction and the acylation, providing easy access to a wide variety of substituted dihydrochalcones.
authors.affiliation: Department of Chemistry, Liverpool Centre for Materials and Catalysis, University of Liverpool, Liverpool, L69 7ZD, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Colbon
authors.forename: Jiwu
authors.initials: J
authors.lastname: Ruan
authors.forename: Mark
authors.initials: M
authors.lastname: Purdie
authors.forename: Keith
authors.initials: K
authors.lastname: Mulholland
authors.forename: Jianliang
authors.initials: J
authors.lastname: Xiao
mesh_terms: D000215:Acylation; D002384:Catalysis; D047188:Chalcones / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D020005:Propanols / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D047188:Chalcones; D006842:Hydrocarbons, Brominated; D020005:Propanols; C006463:allyl alcohol; D010165:Palladium; C015812:dihydrochalcone