title: Acute effects of COREXIT EC9500A on cardiovascular functions in rats.
abstract: These studies characterized cardiovascular responses after an acute inhalation exposure to COREXIT EC9500A, the oil dispersant used in the Deepwater Horizon oil spill. Male Sprague-Dawley rats underwent a single 5-h inhalation exposure to COREXIT EC9500A (average exposure level 27.12 mg/m(3)) or air. On d 1 and 7 following the exposure, rats were implanted with indwelling catheters and changes in heart rate and blood pressure were assessed in response to increasing levels of adrenoreceptor agonists. A separate group of rats was euthanized at the same time points, ventral tail arteries were dissected, and vascular tone along with dose-dependent responses to vasoconstricting and dilating factors were assessed in vitro. Agonist-induced dose-dependent increases in heart rate and blood pressure were greater in COREXIT EC9500A-exposed than in air-exposed rats at 1 d but not 7 d after the exposure. COREXIT EC9500A exposure also induced a rise in basal tone and reduced responsiveness of tail arteries to acetylcholine-induced vasodilation at 1 d but not 7 d following the exposure. These findings demonstrate that an acute exposure to COREXIT EC9500A exerts transient effects on cardiovascular and peripheral vascular functions.
authors.affiliation: Engineering and Controls Technology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. ksk1@cdc.gov
authors.forename: Kristine
authors.initials: K
authors.lastname: Krajnak
authors.forename: Hong
authors.initials: H
authors.lastname: Kan
authors.forename: Stacey
authors.initials: S
authors.lastname: Waugh
authors.forename: G Roger
authors.initials: GR
authors.lastname: Miller
authors.forename: Claud
authors.initials: C
authors.lastname: Johnson
authors.forename: Jenny R
authors.initials: JR
authors.lastname: Roberts
authors.forename: William Travis
authors.initials: WT
authors.lastname: Goldsmith
authors.forename: Mark
authors.initials: M
authors.lastname: Jackson
authors.forename: Walter
authors.initials: W
authors.lastname: McKinney
authors.forename: David
authors.initials: D
authors.lastname: Frazer
authors.forename: Michael L
authors.initials: ML
authors.lastname: Kashon
authors.forename: Vincent
authors.initials: V
authors.lastname: Castranova
mesh_terms: D000818:Animals; D001158:Arteries / Q000737:chemistry / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002320:Cardiovascular Physiological Phenomena / Q000187:drug effects*; D045703:Emulsifying Agents / Q000633:toxicity*; D052918:Environmental Restoration and Remediation / Q000009:adverse effects*; D006339:Heart Rate / Q000187:drug effects; D019570:Inhalation Exposure / Q000009:adverse effects*; D008055:Lipids / Q000633:toxicity*; D008297:Male; D023421:Models, Animal; D059392:Petroleum Pollution; D051381:Rats; D017207:Rats, Sprague-Dawley; D023382:Toxicity Tests, Acute; D014664:Vasodilation / Q000187:drug effects
chemical_list: D045703:Emulsifying Agents; D008055:Lipids; C470995:corexit 9500