title: Schilder's disease: non-invasive diagnosis and successful treatment with human immunoglobulins.
abstract: Schilder's disease (SD) is a rare variant of multiple sclerosis with a predilection to children. It is characterized by focal neurological abnormalities, which are atypical for MS, in conjunction with tumor-like white matter lesions on MRI. We report the case of an 11-year-old girl that demonstrates two important features of the disease: a) the clinical presentation and subsequent course in conjunction with the serial neuroradiological findings stress the feasibility of a non-invasive diagnosis of SD; and b) we report a significant clinical response to treatment with intravenous human Immunoglobulins.
authors.affiliation: Pediatrics A, Schneider Children's Medical Center of Israel, 14 Kaplan St., Petah Tiqwa 49202, Israel. drork@clalit.org.il
authors.forename: Dror
authors.initials: D
authors.lastname: Kraus
authors.forename: Osnat
authors.initials: O
authors.lastname: Konen
authors.forename: Rachel
authors.initials: R
authors.lastname: Straussberg
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001921:Brain / Q000473:pathology; D002648:Child; D003131:Combined Modality Therapy; D002549:Diffuse Cerebral Sclerosis of Schilder / Q000175:diagnosis* / Q000188:drug therapy / Q000628:therapy*; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000627:therapeutic use*; D007167:Immunotherapy; D008279:Magnetic Resonance Imaging; D008775:Methylprednisolone / Q000627:therapeutic use; D018908:Muscle Weakness / Q000209:etiology; D010291:Paresis / Q000209:etiology; D014057:Tomography, X-Ray Computed
chemical_list: D000305:Adrenal Cortex Hormones; D007136:Immunoglobulins; D008775:Methylprednisolone