title: Effect of an age-mismatched and sex-mismatched normal database on the diagnostic performance of ¹⁸F-FDG PET for Alzheimer's disease: the Ishikawa Brain Imaging Study.
abstract: OBJECTIVE
  ¹⁸F-FDG PET with voxel-based statistical image analysis plays an important role in the diagnosis of Alzheimer's disease (AD). However, the effect of an age-matched and sex-matched or mismatched normal database (NDB) on the diagnostic performance of ¹⁸F-FDG PET has not yet been investigated systematically. The aim of this study was to determine whether an age-matched and sex-matched NDB is necessary for the detection of AD using ¹⁸F-FDG PET.
  
  
  METHODS
  We generated 11 NDB sets for ¹⁸F-FDG PET, including six age-specific NDB sets consisting of participants ranging in age from 20 to 70 years, one age-non-specific NDB set, one age-matched NDB set, two sex-specific NDB sets, each consisting of 20 men or 20 women, and one sex-matched NDB set. The average z-scores in predefined AD-specific regions of interest of the PET images were calculated using those NDB sets and a receiver-operating characteristic analysis was carried out to assess the diagnostic performance of ¹⁸F-FDG PET to discriminate 46 patients with AD from 50 normal controls.
  
  
  RESULTS
  There was no significant difference in each area under the receiver-operating characteristic curve using either age-matched/mismatched NDB sets or sex-matched/mismatched NDB sets.
  
  
  CONCLUSIONS
  The diagnostic performance of ¹⁸F-FDG PET was rather insensitive to differences in age or sex in the NDB, indicating that exact age-matched or sex-matched NDB may not be essential for discriminating patients with AD from normal participants using ¹⁸F-FDG PET.
authors.affiliation: The Medical and Pharmacological Research Center Foundation, Hakui-City, Ishikawa, Japan.
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Chen
authors.forename: Miharu
authors.initials: M
authors.lastname: Samuraki
authors.forename: Keisuke
authors.initials: K
authors.lastname: Shima
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yanase
authors.forename: Nozomi
authors.initials: N
authors.lastname: Takeda
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Ono
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Yoshita
authors.forename: Shintaro
authors.initials: S
authors.lastname: Nishimura
authors.forename: Masahito
authors.initials: M
authors.lastname: Yamada
authors.forename: Ichiro
authors.initials: I
authors.lastname: Matsunari
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D003625:Data Collection; D016208:Databases, Factual; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods; D012372:ROC Curve; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012737:Sex Factors; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18