title: Cytotoxic pheofungins from an engineered fungus impaired in posttranslational protein modification.
abstract: What makes a fungus blush? The deletion of a gene that is required for global protein N-acetylation triggers the production of unprecedented metabolites in Aspergillus nidulans. The pronounced red pigmentation of the engineered mutant is caused by pheofungins (benzothiazinone chromophores), the biogenesis of which is strikingly similar to those of pheomelanins found in red bird feathers and hair of Celtic origin.
authors.affiliation: Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany.
authors.forename: Kirstin
authors.initials: K
authors.lastname: Scherlach
authors.forename: Hans-Wilhelm
authors.initials: HW
authors.lastname: Nützmann
authors.forename: Volker
authors.initials: V
authors.lastname: Schroeckh
authors.forename: Hans-Martin
authors.initials: HM
authors.lastname: Dahse
authors.forename: Axel A
authors.initials: AA
authors.lastname: Brakhage
authors.forename: Christian
authors.initials: C
authors.lastname: Hertweck
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D001233:Aspergillus nidulans / Q000235:genetics* / Q000378:metabolism; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects; D005656:Fungal Proteins / Q000378:metabolism*; D005818:Genetic Engineering; D006367:HeLa Cells; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D020014:K562 Cells; D015394:Molecular Structure; D009154:Mutation; D011499:Protein Processing, Post-Translational; D013329:Structure-Activity Relationship; D013843:Thiazines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D001578:Benzopyrans; D001688:Biological Products; D003603:Cytotoxins; D005656:Fungal Proteins; D006571:Heterocyclic Compounds; D013843:Thiazines