title: Test of association between 10 single nucleotide polymorphisms in the oxytocin receptor gene and conduct disorder.
abstract: Animal and human studies have implicated oxytocin in affiliative and prosocial behaviors. We tested whether genetic variation in the oxytocin receptor (OXTR) gene is associated with conduct disorder (CD). Utilizing a family-based sample of adolescent probands recruited from an adolescent substance abuse treatment program, control probands and their families (total sample, n=1750), we conducted three tests of association with CD and 10 single nucleotide polymorphisms (SNPs) in the OXTR gene: (a) family-based comparison utilizing the entire sample; (b) within-Whites, case-control comparison of adolescent patients with CD and controls without CD; and (c) within-Whites case-control comparison of parents of patients and parents of controls. Family-based association tests failed to show significant results (no results P<0.05). While strictly correcting for the number of tests (α=0.002), adolescent patients with CD did not differ significantly from adolescent controls in genotype frequency for the OXTR SNPs tested; similarly, comparison of OXTR genotype frequencies for parents failed to differentiate patient and control family type, except a trend association for rs237889 (P=0.004). We concluded that in this sample, 10 SNPs in the OXTR gene were not significantly associated with CD.
authors.affiliation: Division of Substance Dependence, School of Medicine, University of Colorado-Denver, 12469 East 17th Place, Aurora, CO 80045, USA. joseph.sakai@ucdenver.edu
authors.forename: Joseph T
authors.initials: JT
authors.lastname: Sakai
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Crowley
authors.forename: Michael C
authors.initials: MC
authors.lastname: Stallings
authors.forename: Matthew
authors.initials: M
authors.lastname: McQueen
authors.forename: John K
authors.initials: JK
authors.lastname: Hewitt
authors.forename: Christian
authors.initials: C
authors.lastname: Hopfer
authors.forename: Nicole R
authors.initials: NR
authors.lastname: Hoft
authors.forename: Marissa A
authors.initials: MA
authors.lastname: Ehringer
mesh_terms: D016022:Case-Control Studies; D019955:Conduct Disorder / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D018045:Receptors, Oxytocin / Q000235:genetics*
chemical_list: D018045:Receptors, Oxytocin