title: Ligand-free copper-catalyzed regioselective C-2 arylation of imidazo[2,1-b]thiazoles.
abstract: An effective, regioselective C-2 arylation of imidazo[2,1-b]thiazoles catalyzed by Cu(I) has been developed. This arylation proceeded smoothly without promotion of the ligands, and various functional (22 samples) groups were well tolerated. Preliminary mechanistic studies of this arylation are also reported.
authors.affiliation: Key Laboratory of Mesoscopic Chemistry of MOE, Institute of Chemical Biology and Drug Innovation, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China.
authors.forename: Guoli
authors.initials: G
authors.lastname: Huang
authors.forename: Hongsheng
authors.initials: H
authors.lastname: Sun
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Qiu
authors.forename: Can
authors.initials: C
authors.lastname: Jin
authors.forename: Chen
authors.initials: C
authors.lastname: Lin
authors.forename: Yingzhong
authors.initials: Y
authors.lastname: Shen
authors.forename: Juli
authors.initials: J
authors.lastname: Jiang
authors.forename: Leyong
authors.initials: L
authors.lastname: Wang
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D013844:Thiazoles / Q000737:chemistry*
chemical_list: D007093:Imidazoles; D008024:Ligands; D013844:Thiazoles; D003300:Copper