title: Efficient synthesis of benzofuranones: N-heterocyclic carbene (NHC)/base-catalyzed hydroacylation-Stetter-rearrangement cascade.
abstract: A N-heterocyclic carbene/base-catalyzed cascade reaction leading to the formation of functionalized benzofuranones is reported. The reaction proceeds via an intramolecular hydroacylation of unactivated alkynes followed by an intermolecular Stetter reaction and a base-catalyzed chromanone to benzofuranone rearrangement.
authors.affiliation: Westfälische Wilhelms-Universität, NRW Graduate School of Chemistry, Organisch-Chemisches Institut, Corrensstrasse 40, 48149 Münster, Germany.
authors.forename: Mohan
authors.initials: M
authors.lastname: Padmanaban
authors.forename: Akkattu T
authors.initials: AT
authors.lastname: Biju
authors.forename: Frank
authors.initials: F
authors.lastname: Glorius
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D000480:Alkynes; D001572:Benzofurans; C030011:carbene; D008697:Methane