title: [Role of constitutive and inducible repair in radiation resistance of Escherichia coli].
abstract: Radiation resistance of Escherichia coil cells depends on how efficiently DNA is recovered after damage, which is determined by the function of constitutive and inducible repair branches. The effects of additional mutations of the key genes of constitutive and inducible repair (recA, lexA, recB, polA, lig, gyr, recE, recO, recR, recJ, recQ, uvrD, helD, recN, and ruv) on radiation resistance were studied in E. coli K-12 strain AB 1157 and highly radiation-resistant isogenic strain Gam(r)444. An optimal balance ensuring a high gamma resistance of the Gam(r)444 radiation-resistant E. coli mutant was due to expression of the key SOS repair genes (recA, lexA, recN, and ruv) and activation of the presynaptic functions of the RecF homologous recombination pathway as a result of a possible mutation of the uvrD gene, which codes for repair helicase II.
authors.forename: E P
authors.initials: EP
authors.lastname: Gulevich
authors.forename: V N
authors.initials: VN
authors.lastname: Kuznetsova
authors.forename: V N
authors.initials: VN
authors.lastname: Verbenko
mesh_terms: D004269:DNA, Bacterial / Q000235:genetics / Q000378:metabolism*; D048168:Escherichia coli K12 / Q000235:genetics / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism*; D005720:Gamma Rays; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology / Q000528:radiation effects*; D009154:Mutation; D011836:Radiation Tolerance / Q000502:physiology*; D013014:SOS Response, Genetics / Q000502:physiology / Q000528:radiation effects*
chemical_list: D004269:DNA, Bacterial; D029968:Escherichia coli Proteins