title: Liver transplantation for patients with human immunodeficiency virus and hepatitis C virus coinfection with special reference to hemophiliac recipients in Japan.
abstract: Liver transplantation for patients with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) remains challenging. The advent of highly active antiretroviral therapy (HAART) for HIV has reduced mortality from opportunistic infection related to acquired immunodeficiency syndrome dramatically, while about 50% of patients die of end-stage liver cirrhosis resulting from HCV. In Japan, liver cirrhosis frequently develops after HCV-HIV coinfection resulting from previously transfused infected blood products for hemophilia. The problems of liver transplantation for those patients arise from the need to control calcineurin inhibitor with HAART drugs, the difficulty of using interferon after liver transplantation with HAART, and the need to control intraoperative coagulopathy associated with hemophilia. We review published reports of liver transplantation for these patients in the updated world literature.
authors.affiliation: Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Eguchi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Soyama
authors.forename: Masaaki
authors.initials: M
authors.lastname: Hidaka
authors.forename: Mitsuhisa
authors.initials: M
authors.lastname: Takatsuki
authors.forename: Izumi
authors.initials: I
authors.lastname: Muraoka
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Tomonaga
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanematsu
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D060085:Coinfection; D058625:End Stage Liver Disease / Q000601:surgery* / Q000821:virology; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006467:Hemophilia A / Q000150:complications*; D002836:Hemophilia B / Q000150:complications*; D019698:Hepatitis C, Chronic / Q000150:complications / Q000601:surgery*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016031:Liver Transplantation; D065227:Transfusion Reaction
chemical_list: D019380:Anti-HIV Agents