title: Ultrasound-assisted click chemistry in continuous flow.
abstract: We present a study on ultrasound-promoted click chemistry reactions in a meso-flow reactor synthesis system with a copper reactor and a custom sonication piezoelectric transducer. Copper catalyzed Huisgen 1,3-dipolar cycloadditions were studied in flow with this system. Our results demonstrate that 1,4-disubstituted 1,2,3-triazole products can be generated at low temperatures and with short reaction time in good yield, due to the rate enhancement effect of sonication.
authors.affiliation: Medicinal Chemistry Technologies, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA. noah.tu@abbott.com
authors.forename: Noah P
authors.initials: NP
authors.lastname: Tu
authors.forename: Jill E
authors.initials: JE
authors.lastname: Hochlowski
authors.forename: Stevan W
authors.initials: SW
authors.lastname: Djuric
mesh_terms: D019540:Area Under Curve; D057930:Click Chemistry / Q000379:methods*; D012212:Rheology; D013696:Temperature; D014159:Transducers; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry; D014465:Ultrasonics / Q000379:methods*
chemical_list: D014230:Triazoles