title: Stevens-Johnson syndrome with sulfasalazine treatment: report of two cases.
abstract: We report two cases of Stevens-Johnson syndrome (SJS) associated with the use of sulfasalazine in two ulcerative colitis patients previously tolerant to mesalamine. SJS and toxic epidermal necrolysis (TEN) are very rare adverse cutaneous reactions that can be associated with the use of sulfasalazine. The most severe cases can result in death, and for the others, permanent skin, mucosal or ocular sequelae, which can impair the quality of life in our young IBD patients. Clinicians and patients need to be aware of the signs and symptoms that often precede the appearance of the mucocutaneous lesions in a SJS or TEN, such as fever, influenza-like symptoms, sore throat or burning eyes. For patients with SJS or TEN, immediate withdrawal of the offending medication should be done when blisters or erosions appear in the course of a drug eruption, as this may improve the prognosis.
authors.affiliation: Pharmacy Department, Centre hospitalier de l'Université de Montréal, Montréal, Canada. lydjie.tremblay@umontreal.ca
authors.forename: Lydjie
authors.initials: L
authors.lastname: Tremblay
authors.forename: Guillaume
authors.initials: G
authors.lastname: Pineton de Chambrun
authors.forename: Bénédicte
authors.initials: B
authors.lastname: De Vroey
authors.forename: Céline
authors.initials: C
authors.lastname: Lavogiez
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Delaporte
authors.forename: Jean-Frédéric
authors.initials: JF
authors.lastname: Colombel
authors.forename: Antoine
authors.initials: A
authors.lastname: Cortot
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D005260:Female; D006801:Humans; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis / Q000209:etiology*; D012460:Sulfasalazine / Q000009:adverse effects*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D012460:Sulfasalazine