title: (-)-α-Bisabolol-induced gastroprotection is associated with reduction in lipid peroxidation, superoxide dismutase activity and neutrophil migration.
abstract: This work examined the gastroprotection of (-)-α-bisabolol, an unsaturated optically active sesquiterpene alcohol obtained by the direct distillation essential oil from plants. (-)-α-Bisabolol has been described as a compound capable of reducing the gastric ulcer area in response to absolute ethanol. We evaluated the gastroprotection of (-)-α-bisabolol in ethanol-induced gastric lesions model through histopathological assessment, measurement of the membrane lipids peroxidation (MDA), myeloperoxidase (MPO) activity, superoxide dismutase (SOD) activity, catalase (CAT) activity and the nitrite amount. Our results showed that (-)-α-bisabolol was able to reduce injuries associated with the administration of ethanol and the formation of thiobarbituric acid reactive substances (MDA) was also able to increase SOD activity and reduce the influx of cells inflammatory (neutrophils) in the gastric mucosa. The effect of (-)-α-bisabolol seems to be unrelated to the nitric oxide. (-)-α-Bisabolol caused a reduction of catalase activity. These findings show that (-)-α-bisabolol is able to decrease oxidative stress and inflammatory event associated with the lesions induced by ethanol.
authors.affiliation: Universidade Federal do Ceará, Dep. Fisiologia e Farmacologia, Cel. Nunes de Melo 1127, Rodolfo Teofilo, Fortaleza, Ceara, Brazil. nayrtonf@hotmail.com
authors.forename: Nayrton Flávio Moura
authors.initials: NF
authors.lastname: Rocha
authors.forename: Gersilene Valente de
authors.initials: GV
authors.lastname: Oliveira
authors.forename: Fernanda Yvelize Ramos de
authors.initials: FY
authors.lastname: Araújo
authors.forename: Emiliano Ricardo Vasconcelos
authors.initials: ER
authors.lastname: Rios
authors.forename: Alyne Mara Rodrigues
authors.initials: AM
authors.lastname: Carvalho
authors.forename: Leonardo Freire
authors.initials: LF
authors.lastname: Vasconcelos
authors.forename: Danielle Silveira
authors.initials: DS
authors.lastname: Macêdo
authors.forename: Pedro Marcos Gomes
authors.initials: PM
authors.lastname: Soares
authors.forename: Damião Pergentino De
authors.initials: DP
authors.lastname: Sousa
authors.forename: Francisca Cléa Florenço de
authors.initials: FC
authors.lastname: Sousa
mesh_terms: D000111:Acetylcysteine / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D002374:Catalase / Q000378:metabolism; D002465:Cell Movement / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology; D005753:Gastric Mucosa / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D000081222:Monocyclic Sesquiterpenes; D009504:Neutrophils / Q000378:metabolism / Q000473:pathology*; D009573:Nitrites / Q000378:metabolism; D009195:Peroxidase / Q000378:metabolism; D020011:Protective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D012717:Sesquiterpenes / Q000494:pharmacology* / Q000627:therapeutic use; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: D000081222:Monocyclic Sesquiterpenes; D009573:Nitrites; D020011:Protective Agents; D012717:Sesquiterpenes; C004497:bisabolol; D000431:Ethanol; D008315:Malondialdehyde; D002374:Catalase; D009195:Peroxidase; D013482:Superoxide Dismutase; D000111:Acetylcysteine