title: Design and synthesis of a novel protected mixed ligand siderophore.
abstract: A novel siderophore analog (4) has been designed to facilitate iron transport-mediated drug delivery and drug release. This mixed ligand siderophore analog includes three bidentate ligands intended to octahedrally coordinate iron (III). The ligands include a 2,3-dihydroxy benzoic acid moiety, N(5)-acetyl-N(5)-hydroxy-l-ornithine, and a β-N-hydroxy-α,β-diaminopropionic acid derivative. The total synthesis of 15, a form of 4 that is suitably protected, yet contains a free carboxylic acid for subsequent drug conjugation, is described.
authors.affiliation: Walther Cancer Research Center & Department of Chemistry and Biochemistry, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, IN 46556.
authors.forename: Pingyu
authors.initials: P
authors.lastname: Ding
authors.forename: Clara E
authors.initials: CE
authors.lastname: Schous
authors.forename: Marvin J
authors.initials: MJ
authors.lastname: Miller