title: Evaluation of the in vitro activity of amphotericin B by time-kill curve methodology against large and small capsulate C. neoformans isolates.
abstract: We have evaluated and compared the activity of amphotericin B (AMB) by time-kill curve methodology against 20 clinical Cryptococcus neoformans isolates in which capsule induction in vitro was performed. Overall, large capsulated isolates were more resistant to killing by AMB over time when compared with those small capsulate ones.
authors.affiliation: Departamento de Micologia; Instituto Nacional de Enfermedades Infecciosas, (INEI), ANLIS Dr. C.G. Malbrán, Buenos Aires 1281, Argentina.
authors.forename: Susana
authors.initials: S
authors.lastname: Córdoba
authors.forename: Javier
authors.initials: J
authors.lastname: Afeltra
authors.forename: Roxana G
authors.initials: RG
authors.lastname: Vitale
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D003455:Cryptococcus neoformans / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests; D013997:Time Factors
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B