title: Glutamate decarboxylase and GABA aminotransferase levels in different regions of rat brain on the onset of Leptazol induced convulsions.
abstract: The activities of Glutamate decarboxylase (GAD) and Gamma aminobutyric acid (GABA) were studied in three regions of rat brain in heightened neuronal activity resulting in convulsions by Leptazol. These enzymes were studied in preconvulsive, convulsive and post convulsive phases. The activity of GAD decreases significantly in the preconvulsive phase in all the three regions of brain followed by a significant increase during the convulsive and post convulsive phase in cerebral cortex and cerebellum. The activity of GABA-T decreases maximal during the preconvulsive phase followed by convulsive phase. The activity of this enzyme tended to increase to control values when the postconvulsive phase was reached. Therefore, it is suggested that the concomitant decrease of GAD activity and GABA concentration, is probably an important factor in the onset of convulsions.
authors.affiliation: Deccan College of Medical Sciences, Kanchanbagh, Hyderabad, 58, AP, India. zn_rasheed@rediffmail.com
authors.forename: Zahida
authors.initials: Z
authors.lastname: Nasreen
authors.forename: Tahmeen
authors.initials: T
authors.lastname: Jameel
authors.forename: Ashfaq
authors.initials: A
authors.lastname: Hasan
authors.forename: N
authors.initials: N
authors.lastname: Parveen
authors.forename: B
authors.initials: B
authors.lastname: Sadasivudu
mesh_terms: D000612:4-Aminobutyrate Transaminase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D008297:Male; D010433:Pentylenetetrazole / Q000009:adverse effects*; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000201:enzymology*
chemical_list: D000612:4-Aminobutyrate Transaminase; D005968:Glutamate Decarboxylase; D010433:Pentylenetetrazole