title: Longitudinal risk of cardiovascular events in relation to depression symptoms after discharge among survivors of myocardial infarction. Osaka Acute Coronary Insufficiency Study.
abstract: BACKGROUND
  The purpose of this study was to investigate the association between depression symptoms 1 year after onset and subsequent cardiovascular events among survivors of myocardial infarction (MI).
  
  
  RESULTS
  The participants were recruited from respondents to a district-based survey known as the Osaka Acute Coronary Insufficiency Study. Of 4,271 eligible MI patients, 1,951 completed the Zung Self-Rating Depression Scale (SDS) at their 1-year follow-up examination. After excluding patients who experienced cardiovascular events within 1 year, the data for the remaining 1,307 male patients and 280 female patients were analyzed. Among male patients, depression status at 1 year after onset of MI was significantly related to risk of subsequent cardiovascular events throughout the follow-up period (median 2.9 years). The male patients in the top vs. bottom tertiles of SDS scores (top tertile being ≥42) had a multivariable-adjusted hazard ratio (HR) of 1.67 (95% confidence interval (CI) 1.01-2.77, P=0.04), and a 1-SD increment in SDS score was significantly related to a heightened risk of cardiovascular events, with a multivariable-adjusted HR of 1.30 (95%CI 1.07-1.58, P=0.01). There were no significant associations between SDS scores and cardiovascular events among female patients.
  
  
  CONCLUSIONS
  Depression symptoms 1 year after onset of MI are a significant predictor of subsequent cardiovascular events for male patients.
authors.affiliation: Applied Sociology Department, Kinki University, Osaka, Japan.
authors.forename: Mariko
authors.initials: M
authors.lastname: Shiozaki
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Iso
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ohira
authors.forename: Daisaku
authors.initials: D
authors.lastname: Nakatani
authors.forename: Masahiko
authors.initials: M
authors.lastname: Shimizu
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Sakata
authors.forename: Issei
authors.initials: I
authors.lastname: Komuro
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sato
mesh_terms: D000368:Aged; D003863:Depression / Q000150:complications* / Q000453:epidemiology / Q000523:psychology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000453:epidemiology / Q000523:psychology*; D012737:Sex Factors; D013997:Time Factors