title: Prognostic significance of survivin and tumor necrosis factor-alpha in adult acute lymphoblastic leukemia.
abstract: OBJECTIVE
  Acute lymphoblastic leukemia (ALL) is an aggressive cancer especially in adults as only 20-40% are cured with current treatment regimens.
  
  
  METHODS
  We measured survivin and tumor necrosis factor-alpha (TNF-α) in serum of 30 ALL patients before and after induction therapy and compared to 30 age and sex matched normal adults.
  
  
  RESULTS
  Survivin at cutoff value 15.18 pg/mL was detected in all ALL patients before therapy but in only 83.33% after therapy and not detected in the control group; P<0.001. However TNF-α at cutoff value 60.05 pg/mL was detected in 90% ALL patients before therapy and 86.6% after therapy that was significantly higher than the control group (20%); P<0.001. Survivin showed a significant positive correlation with TNF-α (P<0.05), bone marrow blast cells (P<0.01), peripheral blast cells (P<0.05) and Philadelphia chromosome (P<0.01).
  
  
  CONCLUSIONS
  Survivin may have an important role in the development of acute leukemia and it could serve as a significant prognostic marker.
authors.affiliation: Medical Biochemistry, Faculty of medicine, Ain Shams University, Egypt. manal_basiony@yahoo.com
authors.forename: Manal Basyouni
authors.initials: MB
authors.lastname: Ahmed
authors.forename: Hanan Hussien
authors.initials: HH
authors.lastname: Shehata
authors.forename: Mona
authors.initials: M
authors.lastname: Moussa
authors.forename: Tamer Mohamed
authors.initials: TM
authors.lastname: Ibrahim
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor; D005260:Female; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010677:Philadelphia Chromosome; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood* / Q000175:diagnosis / Q000235:genetics*; D011379:Prognosis; D012372:ROC Curve; D012307:Risk Factors; D012680:Sensitivity and Specificity; D000077022:Survivin; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: C107489:BIRC5 protein, human; D014408:Biomarkers, Tumor; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin; D014409:Tumor Necrosis Factor-alpha