title: Mesenchymal stem cells inhibit proliferation of lymphoid origin haematopoietic tumour cells by inducing cell cycle arrest.
abstract: We have previously shown that mesenchymal stem cells (MSC) inhibit tumour cell proliferation, thus promising a novel therapy for treating cancers. In this study, MSC were generated from human bone marrow samples and characterised based on standard immunophenotyping. When MSC were co-cultured with BV173 and Jurkat tumour cells, the proliferation of tumour cells were profoundly inhibited in a dose dependent manner mainly via cell to cell contact interaction. Further cell cycle analysis reveals that MSC arrest tumour cell proliferation in G0/G1 phase of cell cycle thus preventing the entry of tumour cells into S phase of cell cycle.
authors.affiliation: Immunology Unit, Department of Pathology, Faculty of Medicine and Health Sciences, Universitiy Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
authors.forename: V H
authors.initials: VH
authors.lastname: Sarmadi
authors.forename: C K
authors.initials: CK
authors.lastname: Tong
authors.forename: S
authors.initials: S
authors.lastname: Vidyadaran
authors.forename: M
authors.initials: M
authors.lastname: Abdullah
authors.forename: H F
authors.initials: HF
authors.lastname: Seow
authors.forename: R
authors.initials: R
authors.lastname: Ramasamy
mesh_terms: D002453:Cell Cycle; D049109:Cell Proliferation; D006801:Humans; D016130:Immunophenotyping; D019169:Jurkat Cells / Q000166:cytology; D059630:Mesenchymal Stem Cells / Q000378:metabolism / Q000502:physiology*