title: Attenuation of neuropsychiatric symptoms and caregiver burden in Alzheimer's disease by motor intervention: a controlled trial.
abstract: OBJECTIVE
  To analyze the effects of motor intervention on the neuropsychiatric symptoms of Alzheimer's disease and on the caregivers' burden.
  
  
  METHODS
  This is a controlled trial evaluating the effects of a motor intervention program on the neuropsychiatric symptoms.
  
  
  METHODS
  The intervention was performed on community patients from two university centers specializing in physical exercise for the elderly.
  
  
  METHODS
  Patients with Alzheimer's disease were divided into two groups: sixteen received the motor intervention and sixteen controls (five controls were excluded because of clinical intercurrences).
  
  
  METHODS
  Aerobic exercises (flexibility, strength, and agility) and functional balance exercises were conducted over six months for 60 minutes three times per week.
  
  
  METHODS
  Psychopathological features of patients were evaluated with the Neuropsychiatric Inventory and Cornell Scale for Depression in Dementia. Caregivers were evaluated using the Neuropsychiatric Inventory-Distress and Burden Interview. A two-way analysis of variance (ANOVA) was applied to observe interactions (pre- vs. post-intervention; participants vs. controls).
  
  
  RESULTS
  Patients from the intervention presented a significant reduction in neuropsychiatric conditions when compared to controls (Neuropsychiatric Inventory: F: 11.12; p = 0.01; Cornell Depression scale: F: 11.97; p = 0.01). The burden and stress of caregivers responsible for patients who participated in the intervention significantly decreased when compared to caregivers responsible for controls (Neuropsychiatric Inventory-Distress: F: 9.37; p = 0.01; Burden Interview: F: 11.28; p = 0.01).
  
  
  CONCLUSIONS
  Aerobic exercise was associated with a reduction in the neuropsychiatric symptoms and contributed to attenuate the caregivers' burden. However, the researchers were not blinded to the patient's intervention status, which constitutes an important limitation of this study.
authors.affiliation: UNESP - Universidade Estadual Paulista, Biosciences Institute, Aging and Physical Activity Laboratory, Campus of Rio Claro/SP, Brazil. fstella@rc.unesp.br
authors.forename: Florindo
authors.initials: F
authors.lastname: Stella
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Canonici
authors.forename: Sebastião
authors.initials: S
authors.lastname: Gobbi
authors.forename: Ruth Ferreira Santos
authors.initials: RF
authors.lastname: Galduroz
authors.forename: João de Castilho
authors.initials: Jde C
authors.lastname: Cação
authors.forename: Lílian Teresa Bucken
authors.initials: LT
authors.lastname: Gobbi
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications / Q000523:psychology / Q000534:rehabilitation*; D017028:Caregivers / Q000523:psychology*; D015444:Exercise / Q000502:physiology; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000517:prevention & control* / Q000523:psychology; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D016896:Treatment Outcome