title: Susceptibility of human primary neuronal cells to xenotropic murine leukemia virus-related (XMRV) virus infection.
abstract: BACKGROUND
  Xenotropic Murine Leukemia Virus-related (XMRV) virus is a recently identified mouse gammaretrovirus that has the ability to infect certain human cells. In this study, we investigated the susceptibility of primary neuronal cell types to infection with XMRV.
  
  
  RESULTS
  We observed that the human primary progenitors, progenitor-derived neurons, and progenitor-derived astrocytes supported XMRV multiplication. Interestingly, both progenitors and progenitor-derived neurons were more susceptible compared with progenitor-derived astrocytes. In addition, XMRV-infected Jurkat cells were able to transmit infection to neuronal cells.
  
  
  CONCLUSIONS
  These data suggest that neuronal cells are susceptible for XMRV infection.
authors.affiliation: Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
authors.forename: Veerasamy
authors.initials: V
authors.lastname: Ravichandran
authors.forename: Eugen O
authors.initials: EO
authors.lastname: Major
authors.forename: Carol
authors.initials: C
authors.lastname: Ibe
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Monaco
authors.forename: Mohan Kumar Haleyur
authors.initials: MK
authors.lastname: Girisetty
authors.forename: Indira K
authors.initials: IK
authors.lastname: Hewlett
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000821:virology*; D002454:Cell Differentiation; D004198:Disease Susceptibility; D006801:Humans; D007150:Immunohistochemistry; D019169:Jurkat Cells / Q000166:cytology / Q000821:virology*; D008297:Male; D051379:Mice; D058953:Neural Stem Cells / Q000166:cytology / Q000821:virology*; D009474:Neurons / Q000166:cytology / Q000821:virology*; D061251:Primary Cell Culture; D011471:Prostatic Neoplasms / Q000821:virology; D060888:Real-Time Polymerase Chain Reaction; D012192:Retroviridae Infections / Q000276:immunology / Q000378:metabolism / Q000635:transmission / Q000821:virology*; D014407:Tumor Cells, Cultured; D058008:Xenotropic murine leukemia virus-related virus / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity