title: A variant in the heart-specific fatty acid transport protein 6 is associated with lower fasting and postprandial TAG, blood pressure and left ventricular hypertrophy.
abstract: Fatty acid transport protein 6 (FATP6) is primarily expressed in the heart and seems to be involved in cardiac fatty acid uptake. Therefore, we investigated whether a variation in the 5'-untranslated region of the FATP6 gene is associated with features of the metabolic syndrome and signs of myocardial alteration or heart failure. A total of 755 male participants from a Metabolic Intervention Cohort Kiel were genotyped for the FATP6-7T>A polymorphism (rs2526246) and phenotyped for features of the metabolic syndrome. Participants underwent a glucose tolerance test and the postprandial assessment of metabolic variables after a standardised mixed meal. Left ventricular heart function was evaluated in fifty-four participants. Fasting (P = 0·01) and postprandial (P = 0·02) TAG concentrations were significantly lower in AA homozygotes when compared with wild-type carriers. Homozygosity of allele A was associated with significantly lower postprandial insulin concentrations after a glucose load and significantly lower systolic (P = 0·01) and diastolic (P = 0·01) blood pressure values compared with wild-type carriers. Accordingly, left ventricular heart mass was significantly lower in twenty-seven AA homozygotes in comparison with twenty-seven TT homozygotes, matched for BMI (P = 0·04). In conclusion, the effects of the FATP6 polymorphism on TAG are mediated by affluent dietary fat. The FATP6-7T>A polymorphism may protect from traits of the metabolic syndrome and CVD.
authors.affiliation: Department of Microbiology and Biotechnology, Max Rubner-Institut, Federal Research Institute of Nutrition and Food, Hermann-Weigmann-Straße 1, D-24103 Kiel, Germany.
authors.forename: Annegret
authors.initials: A
authors.lastname: Auinger
authors.forename: Ulf
authors.initials: U
authors.lastname: Helwig
authors.forename: Maria
authors.initials: M
authors.lastname: Pfeuffer
authors.forename: Diana
authors.initials: D
authors.lastname: Rubin
authors.forename: Mark
authors.initials: M
authors.lastname: Luedde
authors.forename: Tim
authors.initials: T
authors.lastname: Rausche
authors.forename: Nour
authors.initials: N
authors.lastname: Eddine El Mokhtari
authors.forename: Ulrich R
authors.initials: UR
authors.lastname: Fölsch
authors.forename: Stefan
authors.initials: S
authors.lastname: Schreiber
authors.forename: Norbert
authors.initials: N
authors.lastname: Frey
authors.forename: Jürgen
authors.initials: J
authors.lastname: Schrezenmeir
mesh_terms: D000483:Alleles; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000235:genetics*; D015331:Cohort Studies; D004041:Dietary Fats / Q000378:metabolism; D005215:Fasting; D050612:Fatty Acid Transport Proteins / Q000235:genetics*; D005947:Glucose / Q000378:metabolism; D005951:Glucose Tolerance Test; D006333:Heart Failure / Q000235:genetics; D006352:Heart Ventricles / Q000473:pathology; D006720:Homozygote; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000235:genetics*; D007328:Insulin / Q000097:blood / Q000235:genetics*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D011110:Polymorphism, Genetic; D019518:Postprandial Period; D014176:Protein Biosynthesis; D014280:Triglycerides / Q000097:blood / Q000235:genetics*
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D050612:Fatty Acid Transport Proteins; D007328:Insulin; C493573:SLC27A6 protein, human; D014280:Triglycerides; D005947:Glucose