title: [Clinical significance of detection of serum values of neuron specific enolase before and after treatment for small cell lung cancer].
abstract: OBJECTIVE
  It has been proven that neuron specific enolase (NSE) was one of the sensitive tumor markers for small cell lung cancer (SCLC). The aim of this study is to investigate the usefulness of serum NSE values as diagnostic and prognostic factors in patients with SCLC.
  
  
  METHODS
  Serum NSE was detected by electrochemiluminescence method in 57 SCLC cases pre- and post-treatment. Survival curves were constructed using the Kaplan-Meier method and then compared using the Log-rank test.
  
  
  RESULTS
  Pre-treatment serum NSE values are prognostic factors for overall survival of patients with SCLC. There was a statistically significant difference in the pretreatment NSE levels of patients who were at an extensive stage compared with the values of those patients who were at a limited stage (P<0.001). The rate of change between the pre- and post-treatment serum NSE levels was not related to the overall survival (P=0.084).
  
  
  CONCLUSIONS
  NSE is an ideal tumor marker for the diagnosis and assessment prognosis of SCLC.
authors.affiliation: Department of Medical Oncology, Heilongjiang Provincial Hospital, Harbin 150001, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Xue
authors.forename: Liyan
authors.initials: L
authors.lastname: Wang
authors.forename: Mingyan
authors.initials: M
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Cai
mesh_terms: D000328:Adult; D000368:Aged; D018450:Disease Progression; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D011379:Prognosis; D055752:Small Cell Lung Carcinoma / Q000097:blood* / Q000175:diagnosis / Q000628:therapy*; D016019:Survival Analysis
chemical_list: D010751:Phosphopyruvate Hydratase