title: Genetic analysis of a novel human adenovirus with a serologically unique hexon and a recombinant fiber gene.
abstract: In February of 1996 a human adenovirus (formerly known as Ad-Cor-96-487) was isolated from the stool of an AIDS patient who presented with severe chronic diarrhea. To characterize this apparently novel pathogen of potential public health significance, the complete genome of this adenovirus was sequenced to elucidate its origin. Bioinformatic and phylogenetic analyses of this genome demonstrate that this virus, heretofore referred to as HAdV-D58, contains a novel hexon gene as well as a recombinant fiber gene. In addition, serological analysis demonstrated that HAdV-D58 has a different neutralization profile than all previously characterized HAdVs. Bootscan analysis of the HAdV-D58 fiber gene strongly suggests one recombination event.
authors.affiliation: Department of Bioinformatics and Computational Biology, George Mason University, Manassas, Virginia, United States of America.
authors.forename: Elizabeth B
authors.initials: EB
authors.lastname: Liu
authors.forename: Leonardo
authors.initials: L
authors.lastname: Ferreyra
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Fischer
authors.forename: Jorge V
authors.initials: JV
authors.lastname: Pavan
authors.forename: Silvia V
authors.initials: SV
authors.lastname: Nates
authors.forename: Nolan Ryan
authors.initials: NR
authors.lastname: Hudson
authors.forename: Damaris
authors.initials: D
authors.lastname: Tirado
authors.forename: David W
authors.initials: DW
authors.lastname: Dyer
authors.forename: James
authors.initials: J
authors.lastname: Chodosh
authors.forename: Donald
authors.initials: D
authors.lastname: Seto
authors.forename: Morris S
authors.initials: MS
authors.lastname: Jones
mesh_terms: D000260:Adenoviruses, Human / Q000145:classification / Q000235:genetics*; D036022:Capsid Proteins / Q000235:genetics*; D019295:Computational Biology; D016679:Genome, Viral / Q000235:genetics; D006801:Humans; D010802:Phylogeny; D011994:Recombinant Proteins / Q000235:genetics*
chemical_list: D036022:Capsid Proteins; D011994:Recombinant Proteins; C018315:hexon capsid protein, Adenovirus