title: Confronting the barriers to develop novel vaccines against brucellosis.
abstract: Brucellosis is an important zoonotic disease of nearly worldwide distribution. This pathogen causes abortion in domestic animals and undulant fever, arthritis, endocarditis and meningitis in humans. Currently, there is no vaccine licensed for brucellosis in humans. Furthermore, control of brucellosis in the human population relies on the control of animal disease. Available animal vaccines may cause disease and in some cases have limited efficacy. This article discusses recent studies in the development of recombinant protein, DNA and live-attenuated vaccines against brucellosis. Furthermore, we call the attention of the scientific community, government and industry professionals to the fact that for these novel vaccine initiatives to become licensed products they need to be effective in natural hosts and bypass the regulatory barriers present in several countries.
authors.affiliation: Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte-Minas Gerais, Brazil. scozeus@icb.ufmg.br
authors.forename: Sérgio Costa
authors.initials: SC
authors.lastname: Oliveira
authors.forename: Guillermo Hernán
authors.initials: GH
authors.lastname: Giambartolomei
authors.forename: Juliana
authors.initials: J
authors.lastname: Cassataro
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001118:Argentina; D001938:Brazil; D002004:Brucella Vaccine / Q000008:administration & dosage / Q000096:biosynthesis / Q000138:chemical synthesis; D002003:Brucella abortus / Q000187:drug effects* / Q000502:physiology; D002006:Brucellosis / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D002417:Cattle; D005260:Female; D033161:Government Regulation; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology / Q000517:prevention & control*; D012756:Sheep; D016896:Treatment Outcome; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000096:biosynthesis / Q000138:chemical synthesis; D019444:Vaccines, DNA / Q000008:administration & dosage / Q000096:biosynthesis / Q000138:chemical synthesis; D022223:Vaccines, Subunit / Q000008:administration & dosage / Q000096:biosynthesis / Q000138:chemical synthesis; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000096:biosynthesis / Q000235:genetics
chemical_list: D002004:Brucella Vaccine; D014613:Vaccines, Attenuated; D019444:Vaccines, DNA; D022223:Vaccines, Subunit; D014614:Vaccines, Synthetic