title: Highlights of 10 years of immunology in Nature Reviews Immunology.
abstract: As Nature Reviews Immunology reaches its 10(th) anniversary, the authors of one of the top-cited articles from each year take a trip down memory lane. We've asked them to look back on the state of research at the time their Review was published, to consider why the article has had the impact it has and to discuss the future directions of their field. This Viewpoint article provides an interesting snapshot of some of the fundamental advances in immunology over the past 10 years. Highlights include our improved understanding of Toll-like receptor signalling, and of immune regulation mediated by regulatory T cells, indoleamine 2,3-dioxygenase, myeloid-derived suppressor cells and interleukin-10. The complexities in the development and heterogeneity of macrophages, dendritic cells and T helper cells continue to engage immunologists, as do the immune processes involved in diseases such as atherosclerosis. We look forward to what the next 10 years of immunology research may bring.
authors.affiliation: Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA. ruslan.medzhitov@yale.edu
authors.forename: Ruslan
authors.initials: R
authors.lastname: Medzhitov
authors.forename: Ethan M
authors.initials: EM
authors.lastname: Shevach
authors.forename: Giorgio
authors.initials: G
authors.lastname: Trinchieri
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Mellor
authors.forename: David H
authors.initials: DH
authors.lastname: Munn
authors.forename: Siamon
authors.initials: S
authors.lastname: Gordon
authors.forename: Peter
authors.initials: P
authors.lastname: Libby
authors.forename: Göran K
authors.initials: GK
authors.lastname: Hansson
authors.forename: Ken
authors.initials: K
authors.lastname: Shortman
authors.forename: Chen
authors.initials: C
authors.lastname: Dong
authors.forename: Dmitry
authors.initials: D
authors.lastname: Gabrilovich
authors.forename: Leona
authors.initials: L
authors.lastname: Gabryšová
authors.forename: Ashleigh
authors.initials: A
authors.lastname: Howes
authors.forename: Anne
authors.initials: A
authors.lastname: O'Garra
mesh_terms: D000486:Allergy and Immunology / Q000266:history / Q000639:trends; D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology; D019070:Cell Lineage / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D049674:History, 21st Century; D006801:Humans; D007109:Immunity; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000276:immunology; D016753:Interleukin-10 / Q000276:immunology; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D008264:Macrophages / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D009000:Monocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D018121:Receptors, Cytokine / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D051193:Toll-Like Receptors / Q000276:immunology
chemical_list: D015703:Antigens, CD; D016207:Cytokines; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D018121:Receptors, Cytokine; D051193:Toll-Like Receptors; D016753:Interleukin-10