title: Abdominal pain: a symptom of levodopa end of dose wearing off in Parkinson's disease.
abstract: Long-term levodopa use is associated with the "End of Dose Wearing Off" (EODWO) phenomenon wherein Parkinsonian symptoms return before a patient's next scheduled dose of levodopa. Wearing off symptoms may include a variety of autonomic, emotional, motor, psychological and sensory abnormalities. Abdominal pain may be an important wearing off symptom as an early indicator of the development of EODWO in Parkinson's disease (PD) patients. In this report, we present two patients on levodopa therapy for PD who developed acute abdominal pain as a symptom of EODWO.
authors.affiliation: Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Ontario, Canada. ranaaq@yahoo.com
authors.forename: A Q
authors.initials: AQ
authors.lastname: Rana
authors.forename: J
authors.initials: J
authors.lastname: Depradine
mesh_terms: D015746:Abdominal Pain / Q000209:etiology*; D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy*
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa