title: Anti-osteoporotic drug release from ordered mesoporous bioceramics: experiments and modeling.
abstract: The release of a potent bone-resorption inhibitor such as zoledronate from a versatile drug delivery system such as SBA 15 has been modeled. The initial and boundary conditions have been defined, together with the system parameters, including the determination of equilibrium and transport parameters. Additionally, the experimental model of the same system has been observed to validate the prediction here developed. This approach represents a powerful tool for the designing of mesoporous implantable drug delivery systems because their release kinetics can be predicted in advance, and this leads to a considerable time and resources saving.
authors.affiliation: Department of Inorganic and Bioinorganic Chemistry, Faculty of Pharmacy, Universidad Complutense de Madrid, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Manzano
authors.forename: Gaetano
authors.initials: G
authors.lastname: Lamberti
authors.forename: Ivan
authors.initials: I
authors.lastname: Galdi
authors.forename: María
authors.initials: M
authors.lastname: Vallet-Regí
mesh_terms: D050071:Bone Density Conservation Agents / Q000737:chemistry*; D002516:Ceramics / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004164:Diphosphonates / Q000737:chemistry*; D004337:Drug Carriers; D004339:Drug Compounding; D007093:Imidazoles / Q000737:chemistry*; D007700:Kinetics; D008956:Models, Chemical; D015203:Reproducibility of Results; D012822:Silicon Dioxide / Q000737:chemistry*; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D004337:Drug Carriers; D007093:Imidazoles; C509969:SBA-15; D000077211:Zoledronic Acid; D012822:Silicon Dioxide