title: Proinflammatory cytokines during the initial phase of oral mucositis in patients with acute lymphoblastic leukaemia.
abstract: OBJECTIVE
  The aim of the study was to compare the production of proinflammatory cytokines during the initial phase of mucositis in patients with acute lymphoblastic leukaemia.
  
  
  METHODS
  A randomized, controlled clinical trial was carried out. Cytokine levels were determined in blood and saliva using ELISA, three times after the administration of methotrexate and only once in the control group.
  
  
  RESULTS
  Comparison of the results showed significant differences for IL-6 and TNF-α in blood and IL-6 in saliva.
  
  
  CONCLUSIONS
  It would seem that 96 h is an ideal time for determining the parameters evaluated both in blood and in saliva.
authors.affiliation: Research Institute, Faculty of Dentistry, University of Zulia, Maracaibo Oncohematology Service, Children's Specialty Hospital, Maracaibo, Venezuela. moralesrojas@cantv.net
authors.forename: Thais
authors.initials: T
authors.lastname: Morales-Rojas
authors.forename: Ninoska
authors.initials: N
authors.lastname: Viera
authors.forename: Alejandra
authors.initials: A
authors.lastname: Morón-Medina
authors.forename: Carmen Julia
authors.initials: CJ
authors.lastname: Alvarez
authors.forename: Alejandra
authors.initials: A
authors.lastname: Alvarez
mesh_terms: D000293:Adolescent; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000032:analysis* / Q000097:blood; D006801:Humans; D018836:Inflammation Mediators / Q000032:analysis* / Q000097:blood; D007375:Interleukin-1 / Q000032:analysis / Q000097:blood; D015850:Interleukin-6 / Q000032:analysis / Q000097:blood; D008727:Methotrexate / Q000627:therapeutic use; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D012463:Saliva / Q000276:immunology; D013280:Stomatitis / Q000097:blood / Q000276:immunology*; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis; D055815:Young Adult
chemical_list: D000964:Antimetabolites, Antineoplastic; D016207:Cytokines; C508600:IL6 protein, human; D018836:Inflammation Mediators; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D008727:Methotrexate