title: [Prostaglandin(PG) E2 in regulation of immunity and inflammatory diseases].
abstract: Prostaglandin(PG) E2 is an important metabolic product of arachidonic acid. PGE2 plays important roles in regulation of fever, inflammatory responses and blood pressure via four functionally antagonistic E-prostanoid (EP) receptors, which are designated as EP1, EP2, EP3 and EP4, respectively. Recently, there is increasing evidence that PGE2 also regulates the maturation of immune cells and immune response. This review aims to briefly summarize and discuss the recent findings regarding the role of PGE2 in regulation of immunity.
authors.affiliation: Department of Physiology and Pathophysiology, Peking University Diabetes Center, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Xue
authors.forename: Yi-Fei
authors.initials: YF
authors.lastname: Miao
authors.forename: Ji-Chun
authors.initials: JC
authors.lastname: Yang
authors.forename: You-Fei
authors.initials: YF
authors.lastname: Guan
mesh_terms: D000818:Animals; D015232:Dinoprostone / Q000502:physiology*; D006801:Humans; D007109:Immunity / Q000502:physiology*; D007249:Inflammation / Q000503:physiopathology*; D018078:Receptors, Prostaglandin E / Q000378:metabolism
chemical_list: D018078:Receptors, Prostaglandin E; D015232:Dinoprostone