title: Effect of intravenous dezocine on fentanyl-induced cough during general anesthesia induction: a double-blinded, prospective, randomized, controlled trial.
abstract: OBJECTIVE
  To evaluate the suppressive effect of intravenous dezocine on fentanyl-induced cough during the induction of general anesthesia.
  
  
  METHODS
  A total of 120 patients, American Society of Anesthesiologists (ASA) physical status I-II, were randomized into two equally sized groups (n = 60). These two groups were given either intravenous dezocine 0.1 mg/kg or a matching placebo (equal volume of 0.9% saline) 10 min before the induction of general anesthesia. Patients were induced with midazolam 0.1 mg/kg, fentanyl 5 μg/kg, propofol 1-1.5 mg/kg, and suxamethonium 1.5 mg/kg. The injection time of fentanyl was less than 2 s in all patients. The occurrence of cough was recorded 2 min after fentanyl bolus.
  
  
  RESULTS
  No patient in the dezocine group had cough, and 42 patients in the control group had cough. This difference was statistically different between these two groups (P = 0.000).
  
  
  CONCLUSIONS
  These results demonstrate that intravenous dezocine 0.1 mg/kg 10 min prior to induction was effective in suppressing fentanyl-induced cough in our patients.
authors.affiliation: Department of Anesthesia, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Zhen-Tao
authors.initials: ZT
authors.lastname: Sun
authors.forename: Chun-Yao
authors.initials: CY
authors.lastname: Yang
authors.forename: Zhi
authors.initials: Z
authors.lastname: Cui
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Xue-Ping
authors.initials: XP
authors.lastname: Han
mesh_terms: D000768:Anesthesia, General / Q000379:methods; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000627:therapeutic use*; D003371:Cough / Q000139:chemically induced* / Q000188:drug therapy*; D004311:Double-Blind Method; D004347:Drug Interactions; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013764:Tetrahydronaphthalenes / Q000627:therapeutic use*
chemical_list: D018686:Anesthetics, Intravenous; D019086:Bridged Bicyclo Compounds, Heterocyclic; D013764:Tetrahydronaphthalenes; D005283:Fentanyl; C010827:dezocine