title: SIP-ing the elixir of youth.
abstract: AMP-activated protein kinase (AMPK) is a conserved cellular fuel gauge previously implicated in aging. In this issue, Lu et al. (2011) describe how age-related deacetylation of Sip2, a subunit of the AMPK homolog in yeast, acts as a life span clock that can be wound backward or forward to modulate longevity.
authors.affiliation: The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. wmair@hsph.harvard.edu
authors.forename: William
authors.initials: W
authors.lastname: Mair
authors.forename: Kristan K
authors.initials: KK
authors.lastname: Steffen
authors.forename: Andrew
authors.initials: A
authors.lastname: Dillin