title: Protective effect of lemongrass oil against dexamethasone induced hyperlipidemia in rats: possible role of decreased lecithin cholesterol acetyl transferase activity.
abstract: OBJECTIVE
  To evaluate the anti-hyperlipidemic activity of lemongrass oil against in dexamethasone induced hyperlipidemia in rats.
  
  
  METHODS
  Administration of dexamethasone was given at 10 mg/kg, sc. to the adult rats for 8 d induces hyperlipidemia characterized by marked increase in serum cholesterol and triglyceride levels along with increase in atherogenic index.
  
  
  RESULTS
  Lemongrass oil (100 and 200 mg/kg, po.) treatment has showed significant inhibition against dexamethasone hyperlipidemia by maintaining the serum levels of cholesterol, triglycerides and atherogenic index near to the normal levels and the antihyperlipidemic effect of the lemongross oil was comparable with atorvastatin 10 mg/kg, po. The possible mechanism may be associated with decrease in lecithin cholesterol acetyl transferase (LCAT) activity.
  
  
  CONCLUSIONS
  These results suggested that Lemon gross oil possess significant anti-hyperlipidemic activity.
authors.affiliation: Department of Pharmacology, Al-Ameen College of Pharmacy, Hosur Road, Bangalore, India. sagvrs@gmail.com
authors.forename: V R Santhosh
authors.initials: VR
authors.lastname: Kumar
authors.forename: Md Naseeruddin
authors.initials: MN
authors.lastname: Inamdar
authors.lastname: Nayeemunnisa
authors.forename: G L
authors.initials: GL
authors.lastname: Viswanatha
mesh_terms: D000818:Animals; D000069059:Atorvastatin; D002784:Cholesterol / Q000097:blood; D031743:Cymbopogon / Q000737:chemistry*; D003907:Dexamethasone / Q000009:adverse effects; D006538:Heptanoic Acids / Q000494:pharmacology; D006949:Hyperlipidemias / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D011758:Pyrroles / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013729:Terpenes / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D014280:Triglycerides / Q000097:blood
chemical_list: D006538:Heptanoic Acids; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D010938:Plant Oils; D011758:Pyrroles; D013729:Terpenes; D014280:Triglycerides; C052901:lemongrass oil; D003907:Dexamethasone; D002784:Cholesterol; D000069059:Atorvastatin; D007862:Phosphatidylcholine-Sterol O-Acyltransferase