title: Prognostic factors in patients with minor salivary gland carcinoma of the oral cavity and oropharynx.
abstract: BACKGROUND
  This study was performed to define prognostic factors and management of minor salivary gland carcinoma of the oral cavity and oropharynx .
  
  
  METHODS
  Retrospective analyses of patients with salivary gland carcinoma of the oral cavity or oropharynx, treated in 1989 to 2006. Statistics included univariate analyses to identify prognostic factors associated with disease-free survival (DFS) and disease-specific survival. A multivariate analysis model was constructed by the Cox method.
  
  
  RESULTS
  Seventy-seven patients constituted our cohort. Significant prognostic factors regarding DFS and disease-specific survival in univariate analyses comprised tumor size, surgical margins, grade, lymph node status, and Karnofsky status and T classification. A multivariate model identified tumor size, grade, surgical margins, and lymph node status significant regarding DFS.
  
  
  CONCLUSIONS
  Tumor size, grade, surgical margins, and lymph node status could be used for a rational design of treatment strategies in these rare tumors.
authors.affiliation: Head and Neck Department, Instituto Nacional de Cancerología, Mexico City, Mexico. josecarr@prodigy.net.mx
authors.forename: José F
authors.initials: JF
authors.lastname: Carrillo
authors.forename: Federico
authors.initials: F
authors.lastname: Maldonado
authors.forename: Liliana C
authors.initials: LC
authors.lastname: Carrillo
authors.forename: Margarita C
authors.initials: MC
authors.lastname: Ramirez-Ortega
authors.forename: Juan G Gómez
authors.initials: JG
authors.lastname: Pizano
authors.forename: C
authors.initials: C
authors.lastname: Melo
authors.forename: José G
authors.initials: JG
authors.lastname: Chanona
authors.forename: K
authors.initials: K
authors.lastname: Luna-Ortiz
authors.forename: Luis F Oñate
authors.initials: LF
authors.lastname: Ocaña
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D015999:Multivariate Analysis; D060787:Neoplasm Grading; D009959:Oropharyngeal Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D012470:Salivary Glands, Minor / Q000473:pathology* / Q000601:surgery; D055815:Young Adult