title: Rhinal-hippocampal interactions during déjà vu.
abstract: OBJECTIVE
  The phenomenon of 'déjà vu' is caused by acute disturbance of mnemonic systems of the medial temporal lobe (MTL). In epileptic patients investigated with intracerebral electrodes, déjà vu can be more readily induced by stimulation of the rhinal cortices (RCs) than the hippocampus (H). Whether déjà vu results from acute dysfunction of the familiarity system alone (sustained by RC) or from more extensive involvement of the MTL region (including H) is debatable.
  
  
  METHODS
  We analysed the synchronisation of intracerebral electroencephalography (EEG) signals recorded from RC, H and amygdala (A) in epileptic patients in whom déjà vu was induced by electrical stimulation. EEG signal correlations (between signals from RC, A and H) were evaluated using a nonlinear regression.
  
  
  RESULTS
  In comparison with RC stimulations that did not lead to déjà vu (DV-), stimulations triggering déjà vu (DV+) were associated with increased broadband EEG correlation (p=0.01). Changes in correlations were significantly different in the theta band for RC-A (p=0.007) and RC-H (p=0.01) and in the beta band for RC-H (p=0.001) interactions.
  
  
  CONCLUSIONS
  Déjà vu is associated with increased EEG signal correlation between MTL structures.
  
  
  CONCLUSIONS
  Results are in favour of a mechanism involving transient co-operation between various MTL structures, not limited to RC alone.
authors.affiliation: INSERM, U751, Laboratoire de Neurophysiologie et Neuropsychologie, Marseille F-13005, France. fabrice.bartolomei@ap-hm.fr
authors.forename: Fabrice
authors.initials: F
authors.lastname: Bartolomei
authors.forename: Emmanuel J
authors.initials: EJ
authors.lastname: Barbeau
authors.forename: Trung
authors.initials: T
authors.lastname: Nguyen
authors.forename: Aileen
authors.initials: A
authors.lastname: McGonigal
authors.forename: Jean
authors.initials: J
authors.lastname: Régis
authors.forename: Patrick
authors.initials: P
authors.lastname: Chauvel
authors.forename: Fabrice
authors.initials: F
authors.lastname: Wendling
mesh_terms: D000328:Adult; D000679:Amygdala / Q000502:physiology; D001611:Beta Rhythm / Q000502:physiology*; D003690:Deja Vu / Q000523:psychology*; D004558:Electric Stimulation; D004566:Electrodes; D004569:Electroencephalography; D004827:Epilepsy / Q000503:physiopathology* / Q000523:psychology; D005260:Female; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology; D008875:Middle Aged; D009415:Nerve Net; D020534:Parahippocampal Gyrus / Q000502:physiology*; D012044:Regression Analysis; D013702:Temporal Lobe / Q000502:physiology; D013826:Theta Rhythm / Q000502:physiology*