title: Biological evaluation of nano-hydroxyapatite-zirconia (HA-ZrO2) composites and strontium-hydroxyapatite (Sr-HA) for load-bearing applications.
abstract: The biological response of strontium (Sr) doped hydroxyapatite (HA) and hydroxyapatite-zirconia (HA-ZrO₂) composites produced by employing sol-gel technology, minimal ZrO₂ loadings, and novel microwave-sintering regimes thereby retarding decomposition, is reported. In vitro evaluations indicate that all materials induce a favorable response from rat osteosarcoma cells. In vivo evaluations show osteoconductivity and biocompatibility for both the Sr-HA and HA-ZrO₂. The materials did not cause any inflammatory response in bone. The Sr-HA displays better biocompatibility which may be due to the incorporation of Sr and the formation of a surface apatite layer.
authors.affiliation: The School of Clinical Dentistry, University of Sheffield, 19 Claremont Crescent, Sheffield S10 2TA, UK.
authors.forename: Ian
authors.initials: I
authors.lastname: Brook
authors.forename: Christine
authors.initials: C
authors.lastname: Freeman
authors.forename: Sarah
authors.initials: S
authors.lastname: Grubb
authors.forename: Niamh
authors.initials: N
authors.lastname: Cummins
authors.forename: Declan
authors.initials: D
authors.lastname: Curran
authors.forename: Colin
authors.initials: C
authors.lastname: Reidy
authors.forename: Stuart
authors.initials: S
authors.lastname: Hampshire
authors.forename: Mark
authors.initials: M
authors.lastname: Towler
mesh_terms: D000818:Animals; D002461:Cell Line, Transformed; D017886:Durapatite / Q000737:chemistry*; D008297:Male; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles; D033362:Powder Diffraction; D051381:Rats; D017208:Rats, Wistar; D013324:Strontium / Q000737:chemistry*; D015040:Zirconium / Q000737:chemistry*
chemical_list: D017886:Durapatite; D015040:Zirconium; C028541:zirconium oxide; D013324:Strontium