title: Formulation and evaluation of metformin oro-dispersible tablets.
abstract: The purpose of this research was to develop oro-dispersible tablets of metformin by direct compression method using super disintegrants approach, effervescent approach and sublimation approach. Powder blend was evaluated for angle of repose, bulk density, tapped density, compressibility index, Hausner's ratio and bulkiness. The tablets were evaluated for uniformity of weight, friability test, hardness, drug content, wetting time, water absorption ratio, disintegration time and in vitro dissolution. Higher dissolution rates were achieved in selected batches (A5, B4, C4, and D3) as compared to marketed product. Batch C4 prepared by effervescent approach was found to have the least disintegration time and maximum in vitro dissolution profile.
authors.affiliation: Rajendra Institute of Technology and Sciences, 4th mile stone, Hisar Road, Sirsa-125055, India.
authors.forename: Munish
authors.initials: M
authors.lastname: Kamboj
authors.forename: Surinder
authors.initials: S
authors.lastname: Goyal
authors.forename: Pankaj
authors.initials: P
authors.lastname: Rakha
authors.forename: Gitika
authors.initials: G
authors.lastname: Arora
authors.forename: Harish
authors.initials: H
authors.lastname: Dureja
authors.forename: Manju
authors.initials: M
authors.lastname: Nagpal
mesh_terms: D000042:Absorption; D000284:Administration, Oral; D000465:Algorithms; D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D006244:Hardness; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000737:chemistry; D007700:Kinetics; D008687:Metformin / Q000008:administration & dosage* / Q000737:chemistry; D011208:Powders; D012995:Solubility; D013607:Tablets; D014867:Water
chemical_list: D007004:Hypoglycemic Agents; D011208:Powders; D013607:Tablets; D014867:Water; D008687:Metformin