title: Contrast enhanced high-resolution diffuse optical tomography of the human brain using ICG.
abstract: Non-invasive diffuse optical tomography (DOT) of the adult brain has recently been shown to improve the spatial resolution for functional brain imaging applications. Here we show that high-resolution (HR) DOT is also advantageous for clinical perfusion imaging using an optical contrast agent. We present the first HR-DOT results with a continuous wave near infrared spectroscopy setup using a dense grid of optical fibers and indocyanine green (ICG) as an exogenic contrast agent. We find an early arrival of the ICG bolus in the intracerebral tissue and a delayed arrival of the bolus in the extracerebral tissue, achieving the separation of both layers. This demonstrates the method's potential for brain perfusion monitoring in neurointensive care patients.
authors.affiliation: Berlin NeuroImaging Center, Charité University Hospital, Department of Neurology, Berlin, Germany. christina.habermehl@charite.de
authors.forename: Christina
authors.initials: C
authors.lastname: Habermehl
authors.forename: Christoph H
authors.initials: CH
authors.lastname: Schmitz
authors.forename: Jens
authors.initials: J
authors.lastname: Steinbrink
mesh_terms: D000328:Adult; D001921:Brain / Q000033:anatomy & histology*; D002560:Cerebrovascular Circulation; D003287:Contrast Media; D003422:Critical Care; D005260:Female; D005456:Fluorescent Dyes; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods; D055620:Optical Phenomena; D019265:Spectroscopy, Near-Infrared / Q000379:methods; D041622:Tomography, Optical / Q000379:methods*
chemical_list: D003287:Contrast Media; D005456:Fluorescent Dyes; D007208:Indocyanine Green