title: [Antibacterial activity of nanostructured silver gel].
abstract: OBJECTIVE
  Evaluation of antimicrobial activity of L-cysteine silver gel against various species of pathogenic and opportunistic microorganisms.
  
  
  METHODS
  Antibacterial activity of L-cysteine silvergel with silver concentration from 1.28 x 10(-3) to 3.75 x10(-3) mole/l was studied by using agar diffusion test. Reparation processes were determined experimentally in 102 male Wistar rats (150 g) by forming under ether anesthesia a 225 mm2 skin wound on the back surface of the body and by introducing virulent strain Staphylococcus aureus 236 24-hour suspension (10(6) CFU/ml) inside the wound. The rat wounds were treated with L-cysteine silver gel once per day for one week and proliferation processes were studied on day 7, 14 and 21.
  
  
  RESULTS
  Antibacterial activity of L-cysteine silver gel was detected against test strains: S. aureus ATCC 25923; Bacillus subtilis 537; Escherichia coli ATCC 25922; Shigella sonnei 1908; Pseudomonas aeruginosa ATCC 27853; Salmonella typhimurium 5715 and Candida albicans ATCC 885-653. Mean period of wound healing was reduced by 3 days when L-cysteine silver gel was used, index of healing acceleration was approximately 20%.
  
  
  CONCLUSIONS
  L-cysteine silver gel has antibacterial and wound healing properties, it can be used for the creation of new medical preparations.
authors.forename: V M
authors.initials: VM
authors.lastname: Chervinets
authors.forename: V M
authors.initials: VM
authors.lastname: Bondarenko
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Chervinets
authors.forename: M M
authors.initials: MM
authors.lastname: Ovchinnikov
authors.forename: A M
authors.initials: AM
authors.lastname: Samoukina
authors.forename: E S
authors.initials: ES
authors.lastname: Mikhaĭlova
authors.forename: M B
authors.initials: MB
authors.lastname: Petrova
authors.forename: E A
authors.initials: EA
authors.lastname: Kharitonova
authors.forename: V M
authors.initials: VM
authors.lastname: Briantseva
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D003545:Cysteine / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D005782:Gels; D008297:Male; D008826:Microbial Sensitivity Tests; D049329:Nanostructures; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D051381:Rats; D012764:Shigella sonnei / Q000187:drug effects; D012834:Silver / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects; D014946:Wound Infection / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D005782:Gels; D012834:Silver; D003545:Cysteine