title: Effectiveness of β(2)-microglobulin adsorption column in treating dialysis-related amyloidosis: a multicenter study.
abstract: OBJECTIVE
  The aim of this study was to determine whether treatment with β(2)-microglobulin adsorption column (Lixelle) affects bone cysts and clinical symptoms in patients with dialysis-related amyloidosis (DRA).
  
  
  METHODS
  Radiographic changes in the number and area of bone cysts of the wrist and the hip joint were compared between 39 hemodialysis (HD) patients treated with Lixelle (Lixelle group) and 28 HD patients treated with conventional therapy as retrospective control (HD group). Clinical symptoms of DRA were also evaluated.
  
  
  RESULTS
  In the Lixelle group, the number of bone cysts and the cystic area in wrist joints were significantly decreased, although the changes in these parameters in hip joints were not significant. In the HD group, the corresponding parameters in the hip joints even significantly increased. Clinical symptoms notably improved after Lixelle treatment.
  
  
  CONCLUSIONS
  Treatment with Lixelle reduces the radiolucency of bone cysts in the wrist joints, and improves clinical symptoms associated with DRA.
authors.affiliation: Hyogo College of Medicine, Nishinomiya, Japan. kuragano @ hyo-med.ac.jp
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kuragano
authors.forename: Toru
authors.initials: T
authors.lastname: Inoue
authors.forename: Kosei
authors.initials: K
authors.lastname: Yoh
authors.forename: Jeongsoo
authors.initials: J
authors.lastname: Shin
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Fujita
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Yoshiya
authors.forename: Jong Il
authors.initials: JI
authors.lastname: Kim
authors.forename: Rumi
authors.initials: R
authors.lastname: Sakai
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sekita
authors.forename: Takeo
authors.initials: T
authors.lastname: Goto
authors.forename: Masafumi
authors.initials: M
authors.lastname: Fukagawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nakanishi
mesh_terms: D000327:Adsorption; D000368:Aged; D000686:Amyloidosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy*; D001845:Bone Cysts / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D006435:Renal Dialysis / Q000009:adverse effects*; D016896:Treatment Outcome; D001613:beta 2-Microglobulin / Q000627:therapeutic use*
chemical_list: D001613:beta 2-Microglobulin