title: Study of genotoxicity and antigenotoxicity of the Cotinus coggygria Scop. methanol extract by Drosophila melanogaster sex-linked recessive lethal test.
abstract: The genotoxic and antigenotoxic effects of Cotinus coggygria Scop. methanol extract was investigated using the Drosophila sex-linked recessive lethal (or SLRL) test. The results presented here show that the methanol extract of Cotinus coggygria in a concentration of 5% and artificial chemical agent ethyl methanesulfonate EMS (0.75 ppm) induce recessive lethal mutations on X-chromosome on Drosophila melanogaster in all broods (I, II and III). Post-treatment with lower concentration of the methanol extract of Cotinus coggygria (2%) was effective in reducing genotoxicity ofmutagen.
authors.affiliation: Department of Biology and Ecology, Faculty of Science, University of Kragujevac 34000, Serbia. stanic@kg.ac.rs
authors.forename: S
authors.initials: S
authors.lastname: Stanić
authors.forename: S
authors.initials: S
authors.lastname: Matić
authors.forename: G
authors.initials: G
authors.lastname: Delić
authors.forename: M
authors.initials: M
authors.lastname: Mihailović
authors.forename: D
authors.initials: D
authors.lastname: Bogojević
authors.forename: S
authors.initials: S
authors.lastname: Solujić
mesh_terms: D027926:Anacardiaceae / Q000737:chemistry*; D000818:Animals; D004249:DNA Damage / Q000187:drug effects*; D004331:Drosophila melanogaster; D000432:Methanol / Q000737:chemistry*; D009153:Mutagens / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D014960:X Chromosome / Q000235:genetics / Q000378:metabolism
chemical_list: D009153:Mutagens; D010936:Plant Extracts; D000432:Methanol