title: Wide-range protection against avian reovirus conferred by vaccination with representatives of four defined genotypes.
abstract: Many isolates of the contagious avian reovirus have been characterized, mainly based on the sequence of their sigma C protein. These isolates have been classified into four genotypes. Currently available vaccines are of limited effectiveness, likely due to the existence of many variants. The aim of this study was to test the efficacy of a vaccine consisting of a mixture of prototypes (representatives) of the four defined genotypic groups of avian reovirus. The prototypes were selected based on their distance from the isolates within each genotype. All prototypes were found to be virulent. Antibodies produced against each of the prototypes neutralized all members of its genotype. Birds were then vaccinated with a mixture of the four prototypes. Results suggest that the 4-valent vaccine can prevent disease and confer broad protection against field isolates of avian reovirus.
authors.affiliation: Division of Avian and Fish Diseases, Kimron Veterinary Institute, Bet Dagan, Israel.
authors.forename: Avishai
authors.initials: A
authors.lastname: Lublin
authors.forename: Dana
authors.initials: D
authors.lastname: Goldenberg
authors.forename: Ezra
authors.initials: E
authors.lastname: Rosenbluth
authors.forename: E Dan
authors.initials: ED
authors.lastname: Heller
authors.forename: Jacob
authors.initials: J
authors.lastname: Pitcovski
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D001715:Bird Diseases / Q000517:prevention & control*; D001717:Birds; D014644:Genetic Variation; D005838:Genotype; D035002:Lower Extremity / Q000473:pathology; D030101:Orthoreovirus, Avian / Q000145:classification / Q000235:genetics / Q000276:immunology*; D012088:Reoviridae Infections / Q000473:pathology / Q000517:prevention & control / Q000662:veterinary*; D017386:Sequence Homology, Amino Acid; D014611:Vaccination / Q000379:methods; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000276:immunology*
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D014765:Viral Vaccines