title: Exclusive facial porokeratosis: histopathologically showing follicular cornoid lamellae.
abstract: Porokeratosis is a heterogeneous group of disorders that are mostly inherited in an autosomal dominant fashion. It has a wide variety of clinical manifestations with a characteristic histological finding of cornoid lamella. Porokeratosis usually affects the trunk or the extremities. Exclusive facial lesions are rare, although 15% of patients with disseminated, superficial, actinic porokeratosis do have facial lesions. Herein, we discuss the case of a 25-year-old woman who noticed the appearance of well-defined, brownish, macular lesions located on both cheeks. She had no other symptoms. A skin examination showed well-demarcated, multiple, brownish macules with raised hyperkeratotic borders on both cheeks and a half-palm-sized, arcuate-shaped lesion formed by grouped macules on the right cheek. No other parts of the body were affected. Histopathological examination of a biopsy specimen obtained from the hyperkeratotic margin gave a diagnosis of porokeratosis with follicular involvement of the cornoid lamellae. Topical pimecrolimus was applied twice a day to the lesions, although little improvement was achieved after 2 months.
authors.affiliation: Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea.
authors.forename: Yoonhee
authors.initials: Y
authors.lastname: Lee
authors.affiliation: Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea.
authors.forename: Eung Ho
authors.initials: EH
authors.lastname: Choi
mesh_terms: D000287:Administration, Topical; D000328:Adult; D065095:Calcineurin Inhibitors; D005145:Face / Q000473:pathology; D005260:Female; D006801:Humans; D017499:Porokeratosis / Q000188:drug therapy / Q000473:pathology*; D016559:Tacrolimus / Q000008:administration & dosage / Q000031:analogs & derivatives
chemical_list: D065095:Calcineurin Inhibitors; C117268:pimecrolimus; D016559:Tacrolimus