title: [Congenital human immunity during 5-day dry immersion].
abstract: The system of congenital immunity was studied in 12 essentially healthy males 18 to 26 years of age subjected to 5-day dry immersion without use of countermeasures. Peripheral blood was analyzed for monocytes, granulocytes and lymphocytes expressing the TLR2+, TLR4+, TLR6+, CD11b+, CD14+, CD16+, CD18+, CD24+, CD36+, CD54+, CD56+ and CD206+ receptors. Expression of early activation marker CD69 on lymphocytes-natural killers was studied in unstimulated and interleukin-2 activated mononuclear cell cultures. The negative shifts in the congenital immunity system in some volunteers at the end of immersion and during recovery can be considered as warnings about depletion of the system reserve and increase of the risk of infectious diseases such as caused by normal microflora which typically does not provoke pathological reactions of the host.
authors.forename: S A
authors.initials: SA
authors.lastname: Ponomarev
authors.forename: M P
authors.initials: MP
authors.lastname: Rykova
authors.forename: E N
authors.initials: EN
authors.lastname: Antropova
authors.forename: T A
authors.initials: TA
authors.lastname: Berendeeva
authors.forename: B V
authors.initials: BV
authors.lastname: Morukov
mesh_terms: D000293:Adolescent; D015703:Antigens, CD / Q000096:biosynthesis* / Q000276:immunology; D002478:Cells, Cultured; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D006098:Granulocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007101:Immersion / Q000009:adverse effects; D007113:Immunity, Innate; D007376:Interleukin-2 / Q000276:immunology / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D009000:Monocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D009894:Opportunistic Infections / Q000209:etiology / Q000517:prevention & control; D012306:Risk; D051193:Toll-Like Receptors / Q000096:biosynthesis* / Q000276:immunology; D018474:Weightlessness Simulation / Q000009:adverse effects / Q000379:methods*; D055815:Young Adult
chemical_list: D015703:Antigens, CD; D007376:Interleukin-2; D051193:Toll-Like Receptors