title: Biomimetic asymmetric hydrogenation: in situ regenerable Hantzsch esters for asymmetric hydrogenation of benzoxazinones.
abstract: A catalytic amount of Hantzsch ester that could be regenerated in situ by Ru complexes under hydrogen gas has been employed in the biomimetic asymmetric hydrogenation of benzoxazinones with up to 99% ee in the presence of chiral phosphoric acid. The use of hydrogen gas as a reductant for the regeneration of Hantzsch esters makes this hydrogenation an ideal atom economic process.
authors.affiliation: State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, P. R. China.
authors.forename: Qing-An
authors.initials: QA
authors.lastname: Chen
authors.forename: Mu-Wang
authors.initials: MW
authors.lastname: Chen
authors.forename: Chang-Bin
authors.initials: CB
authors.lastname: Yu
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.forename: Duo-Sheng
authors.initials: DS
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.forename: Yong-Gui
authors.initials: YG
authors.lastname: Zhou
mesh_terms: D048588:Benzoxazines / Q000737:chemistry*; D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry*; D006865:Hydrogenation; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D048588:Benzoxazines; D004952:Esters; D009942:Organometallic Compounds; D012428:Ruthenium; D006859:Hydrogen