title: Influence of two barrier membranes on staged guided bone regeneration and osseointegration of titanium implants in dogs. Part 2: augmentation using bone graft substitutes.
abstract: OBJECTIVE
  To assess the influence of two barrier membranes and two bone graft substitutes on staged guided bone regeneration and osseointegration of titanium implants in dogs.
  
  
  METHODS
  Saddle-type defects were prepared in the lower jaws of 6 fox hounds and randomly filled with a natural bone mineral (NBM) and a biphasic calcium phosphate (SBC) and allocated to either an in situ gelling polyethylene glycol (PEG) or a collagen membrane (CM). At 8 weeks, modSLA titanium implants were inserted and left to heal in a submerged position. At 8+2 weeks, respectively, dissected blocks were processed for histomorphometrical analysis (e.g., mineralized tissue [MT], bone-to-implant contact [BIC]).
  
  
  RESULTS
  The mean MT values (mm2) and BIC values (%) tended to be higher in the PEG groups (MT: NBM [3.4±1.7]; SBC [4.2±2]/BIC: NBM [67.7±16.9]; SBC [66.9±17.8]) when compared with the corresponding CM groups (MT: NBM [2.5±0.8]; SBC [2.3±1.6]/BIC: NBM [54.1±22.6]; SBC [61±8.7]). These differences, however, did not reach statistical significance.
  
  
  CONCLUSIONS
  It was concluded that all augmentation procedures investigated supported bone regeneration and staged osseointegration of modSLA titanium implants.
authors.affiliation: Department of Oral Surgery, Heinrich Heine University, Düsseldorf, Germany.
authors.forename: Ilja
authors.initials: I
authors.lastname: Mihatovic
authors.forename: Jürgen
authors.initials: J
authors.lastname: Becker
authors.forename: Vladimir
authors.initials: V
authors.lastname: Golubovic
authors.forename: Andrea
authors.initials: A
authors.lastname: Hegewald
authors.forename: Frank
authors.initials: F
authors.lastname: Schwarz
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000494:pharmacology*; D002130:Calcium Phosphates; D003758:Dental Implantation, Endosseous / Q000379:methods*; D015921:Dental Implants; D017267:Dental Prosthesis Design; D004285:Dogs; D048091:Guided Tissue Regeneration / Q000379:methods*; D008334:Mandible / Q000601:surgery*; D008567:Membranes, Artificial; D016348:Osseointegration; D011897:Random Allocation; D018709:Statistics, Nonparametric; D013499:Surface Properties; D014025:Titanium
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; D015921:Dental Implants; D008567:Membranes, Artificial; D014025:Titanium