title: Evaluation of oxidative stress in children with congenital heart defects.
abstract: BACKGROUND
  A significant cause of death and chronic illness in childhood is caused by cardiovascular diseases, including congenital heart disease (CHD). This study aims to investigate the oxidative stress status and to establish its association with CHD in children.
  
  
  METHODS
  The study involves measurements of malondialdehyde (MDA), protein carbonyl (PCO), total anti-oxidant capacity, high-sensitive C-reactive protein (hs-CRP), fibrinogen and cytokine (interleukin [IL-6] and tumor necrosis factor-α) levels in 43 children with CHD and 30 healthy age-matched children.
  
  
  RESULTS
  MDA, PCO, hs-CRP, fibrinogen, IL-6 and tumor necrosis factor-α were significantly elevated while total anti-oxidant capacity was significantly declined in patients compared with the controls. MDA was positively correlated with PCO, hs-CRP, Qp/Qs and systolic pulmonary artery pressure. PCO was positively correlated with hs-CRP, fibrinogen, IL-6 and systolic pulmonary artery pressure.
  
  
  CONCLUSIONS
  Oxidative stress and its association with other markers in children with CHD was established. To the best of our knowledge, this is the first time that PCO has been used as a biomarker in CHD and it may be employed as a new diagnostic biomarker in CHD and in the assessment of its severity.
authors.affiliation: Department of Pediatrics, University of Dicle, Diyarbakir, Turkey. ayfergozu@dicle.edu.tr
authors.forename: Ayfer Gözü
authors.initials: AG
authors.lastname: Pirinccioglu
authors.forename: Omer
authors.initials: O
authors.lastname: Alyan
authors.forename: Göksel
authors.initials: G
authors.lastname: Kizil
authors.forename: Murat
authors.initials: M
authors.lastname: Kangin
authors.forename: Nurcan
authors.initials: N
authors.lastname: Beyazit
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D002648:Child; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006330:Heart Defects, Congenital / Q000378:metabolism*; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress; D050050:Protein Carbonylation; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; D016207:Cytokines; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D008315:Malondialdehyde; D005340:Fibrinogen; D002097:C-Reactive Protein