title: Association between plasma homocysteine levels and obstructive sleep apnoea in patients with ischaemic stroke.
abstract: We aimed to investigate the association between plasma homocysteine and obstructive sleep apnoea (OSA) syndrome in patients with ischaemic stroke. A total of 102 patients with ischaemic stroke were classified into four OSA groups based on their apnoea-hypopnoea index (AHI): absent (AHI < 5/hour); mild (5-14/hour); moderate (15-30/hour); and severe (> 30/hour). The mean (± standard deviation) homocysteine levels in the four OSA groups were: absent, 8.98 ± 3.74 μmol/L; mild, 11.46 ± 3.31 μmol/L; moderate, 14.18 ± 4.36 μmol/L; and severe, 18.57 ± 4.56 μmol/L; and these differences were statistically significant (p < 0.001). The Pearson correlation analysis revealed a positive correlation between homocysteine levels and the severity of AHI (r = 0.482, p < 0.001). Multiple linear regression analysis showed that AHI and folate were independent predictors of homocysteine levels (R(2) = 0.539, p < 0.001, β for AHI = 0.259, β for folate = -0.400). In conclusion, the severity of OSA is significantly associated with elevated homocysteine levels in patients with ischaemic stroke, and this association is independent of other factors that cause elevation in homocysteine.
authors.affiliation: Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China.
authors.forename: Maogang
authors.initials: M
authors.lastname: Chen
authors.forename: Bona
authors.initials: B
authors.lastname: Wu
authors.forename: Xinchun
authors.initials: X
authors.lastname: Ye
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Zhou
authors.forename: Xuanye
authors.initials: X
authors.lastname: Yue
authors.forename: Qizhang
authors.initials: Q
authors.lastname: Wang
authors.forename: Wanxiang
authors.initials: W
authors.lastname: Wang
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Jiang
authors.forename: Xuegan
authors.initials: X
authors.lastname: Lian
authors.forename: Zhaoyao
authors.initials: Z
authors.lastname: Chen
authors.forename: Gelin
authors.initials: G
authors.lastname: Xu
authors.forename: Xinfeng
authors.initials: X
authors.lastname: Liu
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000097:blood* / Q000150:complications; D003430:Cross-Sectional Studies; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications; D011446:Prospective Studies; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000150:complications; D020521:Stroke / Q000097:blood* / Q000150:complications
chemical_list: D006710:Homocysteine