title: Bioinspired synthesis of hirsutellones A, B, and C.
abstract: The total synthesis of hirsutellones A (1), B (2), and C (3) has been achieved through a bioinspired late-stage sequence starting from advanced intermediate 6. The sequence proceeded via labile intermediate 17,1'-dehydrohirsutellone B (5) and delivered, in addition to the natural products (1-3), hirsutellone analogue 1',2',17-epi-hirsutellone C (1',2',17-epi-3).
authors.affiliation: Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. kcn@scripps.edu
authors.forename: K C
authors.initials: KC
authors.lastname: Nicolaou
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Sun
authors.forename: David
authors.initials: D
authors.lastname: Sarlah
authors.forename: Weiqiang
authors.initials: W
authors.lastname: Zhan
authors.forename: T Robert
authors.initials: TR
authors.lastname: Wu
mesh_terms: D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D014242:Trichoderma / Q000737:chemistry
chemical_list: D006576:Heterocyclic Compounds, 4 or More Rings; C568588:hirsutellone A; C545159:hirsutellone B; C568589:hirsutellone C