title: Dissecting the PCP pathway: one or more pathways?: Does a separate Wnt-Fz-Rho pathway drive morphogenesis?
abstract: Planar cell polarity (PCP), the alignment of cells within 2D tissue planes, involves a set of core molecular regulators highly conserved between animals and cell types. These include the transmembrane proteins Frizzled (Fz) and VanGogh and the cytoplasmic regulators Dishevelled (Dsh) and Prickle. It is widely accepted that this core forms part of a 'PCP pathway' for signal transduction, which can affect cell morphology through activation of an evolutionary ancient regulatory module involving Rho family GTPases and Myosin II, and/or the JNK kinase cascade. We have re-examined the evidence for interactions between the proposed PCP pathway components, and question the placing of the cell morphology regulators in the same pathway as the PCP core. While Fz and Dsh are clearly involved in both PCP and Rho-based cell morphology regulation, available evidence cannot currently discriminate whether these processes are linked mechanistically by a shared Fz/Dsh population, or pass by two distinct pathways.
authors.affiliation: Université Pierre et Marie Curie and CNRS, UMR 7009 Biologie du Développement, Observatoire Océanologique, Villefranche-sur-Mer, France. lapebie@obs-vlfr.fr
authors.forename: Pascal
authors.initials: P
authors.lastname: Lapébie
authors.forename: Carole
authors.initials: C
authors.lastname: Borchiellini
authors.forename: Evelyn
authors.initials: E
authors.lastname: Houliston
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D000818:Animals; D016764:Cell Polarity; D000072261:Dishevelled Proteins; D004330:Drosophila / Q000166:cytology / Q000254:growth & development / Q000378:metabolism; D029721:Drosophila Proteins / Q000378:metabolism*; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism; D051157:Frizzled Receptors / Q000378:metabolism; D054262:Gastrulation; D020935:MAP Kinase Signaling System; D051379:Mice; D009024:Morphogenesis; D024462:Myosin Type II / Q000378:metabolism; D009348:Nematoda / Q000166:cytology / Q000254:growth & development / Q000378:metabolism; D010750:Phosphoproteins / Q000378:metabolism; D010802:Phylogeny; D060449:Wnt Signaling Pathway; D014981:Xenopus / Q000254:growth & development / Q000378:metabolism; D029867:Xenopus Proteins; D020741:rho GTP-Binding Proteins / Q000378:metabolism; D054460:rho-Associated Kinases / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C000606586:DVL1 protein, Xenopus; D000072261:Dishevelled Proteins; D029721:Drosophila Proteins; D051157:Frizzled Receptors; D010750:Phosphoproteins; D029867:Xenopus Proteins; C000606588:dsh protein, Drosophila; D054460:rho-Associated Kinases; D024462:Myosin Type II; D020741:rho GTP-Binding Proteins