title: The change of QEEG prefrontal cordance as a response predictor to antidepressive intervention in bipolar depression. A pilot study.
abstract: OBJECTIVE
  The aim of the study was to examine whether the change of quantitative EEG (QEEG) theta prefrontal cordance after one week of various antidepressive interventions predicts response to a 4-week treatment in patients with bipolar depression.
  
  
  METHODS
  We investigated 20 inpatients who completed a 4-week treatment. EEG data were monitored at baseline and after 1 week of treatment. QEEG cordance was computed at 3 frontal electrodes (Fp1, Fp2, Fz) in theta frequency band. Depressive symptoms and clinical status were assessed using Montgomery-Åsberg Depression Rating Scale (MADRS), Clinical Global Impression (CGI) and Young Mania Rating Scale (YMRS).
  
  
  RESULTS
  Seven of 8 responders (reduction of MADRS ≥50%) and only 2 of 12 non-responders had decreased prefrontal theta cordance value after the first week of treatment (p = 0.02). The positive and negative predictive values of cordance reduction for response were 0.78 and 0.91, respectively. We also found significant differences in cordance value reductions between responders and non-responders after week 1 and higher baseline cordance in responders.
  
  
  CONCLUSIONS
  The change in prefrontal theta cordance was associated with subsequent change in depressive symptoms and potentially might be a useful tool in the early detection of acute response to antidepressive interventions in bipolar depressed patients.
authors.affiliation: Prague Psychiatric Center, Ustavni 91, Prague 8, Bohnice 181 03, Czech Republic. bares@pcp.lf3.cuni.cz
authors.forename: Martin
authors.initials: M
authors.lastname: Bares
authors.forename: Tomas
authors.initials: T
authors.lastname: Novak
authors.forename: Martin
authors.initials: M
authors.lastname: Brunovsky
authors.forename: Miloslav
authors.initials: M
authors.lastname: Kopecek
authors.forename: Pavla
authors.initials: P
authors.lastname: Stopkova
authors.forename: Vladimir
authors.initials: V
authors.lastname: Krajca
authors.forename: Cyril
authors.initials: C
authors.lastname: Höschl
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000473:pathology*; D004569:Electroencephalography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011237:Predictive Value of Tests; D017397:Prefrontal Cortex / Q000187:drug effects* / Q000503:physiopathology; D011569:Psychiatric Status Rating Scales; D012372:ROC Curve; D018709:Statistics, Nonparametric; D013826:Theta Rhythm / Q000187:drug effects* / Q000502:physiology
chemical_list: D000928:Antidepressive Agents