title: Identification of a blood-based biological signature in subjects with psychiatric disorders prior to clinical manifestation.
abstract: OBJECTIVE
  To determine whether a molecular signature is present in blood of patients with psychiatric disorders before manifestation of symptoms.
  
  
  METHODS
  Multiplex immunoassay analyses were carried out using serum obtained from two case-control studies of schizophrenia (n = 75) and bipolar disorder (n = 110) patients and their matched controls. The samples were drawn within 1 month before estimated onset of illness.
  
  
  RESULTS
  This led to identification of 20 molecules which were altered in pre-schizophrenia and 14 molecules in pre-bipolar disorder subjects compared to controls. Only two of these molecular changes were identical in both data sets and predictive testing confirmed that the biomarker signatures for pre-schizophrenia and pre-bipolar disorder were dissimilar.
  
  
  CONCLUSIONS
  The present results suggest that there are distinct serum alterations that occur before clinical manifestation of schizophrenia and bipolar disorder. These findings could lead to development of diagnostic tests to help clinical psychiatrists identify and classify vulnerable patients early in the disease process, allowing for earlier and more effective therapeutic intervention.
authors.affiliation: Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.
authors.forename: Emanuel
authors.initials: E
authors.lastname: Schwarz
authors.forename: Paul C
authors.initials: PC
authors.lastname: Guest
authors.forename: Hassan
authors.initials: H
authors.lastname: Rahmoune
authors.forename: Daniel
authors.initials: D
authors.lastname: Martins-de-Souza
authors.forename: David W
authors.initials: DW
authors.lastname: Niebuhr
authors.forename: Natalya S
authors.initials: NS
authors.lastname: Weber
authors.forename: David N
authors.initials: DN
authors.lastname: Cowan
authors.forename: Robert H
authors.initials: RH
authors.lastname: Yolken
authors.forename: Michael
authors.initials: M
authors.lastname: Spain
authors.forename: Anthony
authors.initials: A
authors.lastname: Barnes
authors.forename: Sabine
authors.initials: S
authors.lastname: Bahn
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001714:Bipolar Disorder / Q000097:blood* / Q000175:diagnosis*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007118:Immunoassay / Q000295:instrumentation / Q000379:methods; D008297:Male; D011237:Predictive Value of Tests; D062706:Prodromal Symptoms; D040901:Proteomics / Q000295:instrumentation / Q000379:methods; D012559:Schizophrenia / Q000097:blood / Q000175:diagnosis; D055815:Young Adult
chemical_list: D015415:Biomarkers