title: Clinical significance of conventional serum autoantibodies for various liver diseases in a Chinese population.
abstract: OBJECTIVE
  The aim of this study was to investigate the prevalence of autoantibodies in various liver diseases and evaluate the performance parameters of AMA, ANA and their combinations for PBC.
  
  
  METHODS
  This study enrolled 115 PBC patients, 695 patients with other liver diseases and 105 healthy subjects.
  
  
  RESULTS
  AMA were detected mainly in PBC patients, while ANA were detected in all categories. The high titer and multiple nuclear dot, rim-like and centromere (MRC) patterns of ANA were found in the majority of PBC patients, in contrast to moderate titers and other patterns. All the liver diseases but HAV and NAFLD had significantly independent association with ANA. The combination of MRC patterns and AMA showed superior performance parameters for PBC.
  
  
  CONCLUSIONS
  Although ANA can occur in various liver diseases, high titer and MRC patterns of ANA are more specific for PBC. The combination of MRC patterns and AMA has superior performance for PBC.
authors.affiliation: Department of Laboratory Diagnostics, Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Zaixing
authors.initials: Z
authors.lastname: Yang
authors.forename: Yan
authors.initials: Y
authors.lastname: Liang
authors.forename: Baodong
authors.initials: B
authors.lastname: Qin
authors.forename: Chang
authors.initials: C
authors.lastname: Li
authors.forename: Renqian
authors.initials: R
authors.lastname: Zhong
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000974:Antibodies, Antinuclear / Q000097:blood; D044466:Asian People; D001323:Autoantibodies / Q000097:blood*; D016022:Case-Control Studies; D002681:China; D005260:Female; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000097:blood / Q000276:immunology; D008107:Liver Diseases / Q000097:blood* / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000276:immunology; D015999:Multivariate Analysis; D012727:Sex Characteristics; D017186:Titrimetry
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies