title: The role of the adenomatous polyposis coli (APC) in oral squamous cell carcinoma.
abstract: The main cause of death in oral squamous cell carcinomas (OSCC) is metastasis. Intercellular adhesion is mediated by a family of glycoproteins called cadherins and other molecules like catenins and APC (adenomatous polyposis coli) among other. The WNT (wingless-type) gene family is a group of genes, key signaling pathway for embryonic development and oncogenesis. The goal of this paper is to describe the role of the APC gene, and its derivatives, in the carcinogenicity pathway of WNT-1, identifying its role as a tumor suppressor gene in OSCC, while describing the genetic (loss of heterozygosity and mutations) and epigenetic alterations that modulate its expression and evaluate its relationship with the clinicopathological parameters of this type of tumors. As for APC, its activity as a tumor suppressor gene appears muted on a relatively frequent basis in these tumors, either by LOH, mutations or epigenetic control mechanisms, thus resulting in a low degree of agreement between the results of different studies.
authors.affiliation: Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Entrerríos s/n, Santiago de Compostela C.P. 15782, Spain. perezsayans@gmail.com
authors.forename: Mario
authors.initials: M
authors.lastname: Pérez-Sayáns
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Suárez-Peñaranda
authors.forename: Michel
authors.initials: M
authors.lastname: Herranz-Carnero
authors.forename: Pilar
authors.initials: P
authors.lastname: Gayoso-Diz
authors.forename: Francisco
authors.initials: F
authors.lastname: Barros-Angueira
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Gándara-Rey
authors.forename: Abel
authors.initials: A
authors.lastname: García-García
mesh_terms: D025601:Adenomatous Polyposis Coli Protein / Q000235:genetics* / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000378:metabolism; D044127:Epigenesis, Genetic / Q000235:genetics; D006801:Humans; D019656:Loss of Heterozygosity / Q000235:genetics; D009062:Mouth Neoplasms / Q000235:genetics* / Q000378:metabolism; D009154:Mutation / Q000235:genetics; D060449:Wnt Signaling Pathway / Q000235:genetics; D051155:Wnt1 Protein / Q000378:metabolism
chemical_list: D025601:Adenomatous Polyposis Coli Protein; D051155:Wnt1 Protein