title: Evaluation of the antipsoriatic activity of Aloe vera leaf extract using a mouse tail model of psoriasis.
abstract: Aloe vera gel is used traditionally for the treatment of skin diseases, including psoriasis. An ethanolic extract of the gel was assessed for antipsoriatic activity using a mouse tail model of psoriasis. The extract produced a significant differentiation in the epidermis, as seen from its degree of orthokeratosis (85.07 ± 3.36%) when compared with the negative control (17.30 ± 4.09%). This was equivalent to the effect of the standard positive control, tazarotene (0.1%) gel, which showed a 90.03 ± 2.00% degree of orthokeratosis. The ethanolic extract of Aloe vera leaf gel also produced a significant increase in relative epidermal thickness when compared with the control group, whereas the standard tazarotene showed no change. Taken together, the extract showed an overall antipsoriatic activity of 81.95%, compared with 87.94 for tazarotene, in the mouse tail model for psoriasis.
authors.affiliation: Department of Phytopharmacy and Phytomedicine (TIFAC CORE HD), JSS College of Pharmacy, Rocklands, Ooty, India. dhanabalsp@rediffmail.com
authors.forename: S P
authors.initials: SP
authors.lastname: Dhanabal
authors.forename: L
authors.initials: L
authors.lastname: Priyanka Dwarampudi
authors.forename: N
authors.initials: N
authors.lastname: Muruganantham
authors.forename: R
authors.initials: R
authors.lastname: Vadivelan
mesh_terms: D000504:Aloe / Q000737:chemistry*; D000818:Animals; D002454:Cell Differentiation; D003879:Dermatologic Agents / Q000627:therapeutic use; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004817:Epidermis / Q000187:drug effects / Q000473:pathology; D000431:Ethanol / Q000737:chemistry; D007642:Keratosis / Q000188:drug therapy / Q000473:pathology; D008297:Male; D051379:Mice; D009539:Nicotinic Acids / Q000627:therapeutic use*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry*; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology; D013623:Tail / Q000187:drug effects / Q000473:pathology; D012176:Retinoids
chemical_list: D003879:Dermatologic Agents; D000431:Ethanol; D009539:Nicotinic Acids; D010936:Plant Extracts; C086827:tazarotene; D012176:Retinoids