title: Correlation between common genetic variants and risk factors associated with prediction of cardiovascular diseases in dyslipidemic patients.
abstract: OBJECTIVE
  The aim of the study was to investigate genetic variants predicting cardiovascular events in patients with dyslipidemia and compare its relationship with common risk factors including hyperlipidemia, metabolic syndrome, history of acute myocardial infarction, thrombosis, obesity, and smoking.
  
  
  METHODS
  Five hundred two individuals divided into six groups corresponding with the risk factors and a control group of normolypidemic patients were analyzed for the presence of eight mutations and polymorphisms (endothelial nitric oxide synthase -786T → C and G894T; lymphotoxin A C804A; angiotensin-converting enzyme [ACE] ins/del; human platelet antigen 1 a/b; beta-fibrinogen -455G → A; apolipoprotein B [ApoB] R3500Q; APOE E2/E3/E4) using the ViennaLab CVD Strip assay.
  
  
  RESULTS
  ACE deletions are the most frequent genetic variants in risk groups of dyslipidemic patients (from 58% in cardiovascular events to 51% in smokers). We found a strong relationship between genetic variants and risk factors. G894T is significantly associated with smoking (value of odds ratio [OR] = 1.62, p = 0.04), and ACE deletions are negatively associated with cardiovascular events (OR = 0.62, p = 0.03).
  
  
  CONCLUSIONS
  Significant associations between genetic variants predicting cardiovascular events and common risk factors in dyslipidemic patients were found.
authors.affiliation: Department of Clinical Biochemistry and Pathobiochemistry, 2nd Faculty of Medicine, Charles University, Faculty Hospital Motol, Prague, Czech Republic. kotaska@email.cz
authors.forename: Karel
authors.initials: K
authors.lastname: Kotaska
authors.forename: Jitka
authors.initials: J
authors.lastname: Kolarova
authors.forename: Katerina
authors.initials: K
authors.lastname: Kotrcova
authors.forename: Jana
authors.initials: J
authors.lastname: Cepova
authors.forename: Richard
authors.initials: R
authors.lastname: Prusa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000235:genetics*; D050171:Dyslipidemias / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D011237:Predictive Value of Tests; D012307:Risk Factors; D012907:Smoking / Q000235:genetics; D055815:Young Adult
chemical_list: C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III; D007703:Peptidyl-Dipeptidase A