title: Noscapine inhibits tumor growth in TMZ-resistant gliomas.
abstract: Noscapine, a common oral antitussive agent, has been shown to have potent antitumor activity in a variety of cancers. Treatment of glioblastoma multiforme (GBM) with temozolomide (TMZ), its current standard of care, is problematic because the tumor generally recurs and is then resistant to this drug. We therefore investigated the effects of noscapine on human TMZ-resistant GBM tumors. We found that noscapine significantly decreased TMZ-resistant glioma cell growth and invasion. Using the intracranial xenograft model, we showed that noscapine increased survival of animals with TMZ-resistant gliomas. Thus noscapine can provide an alternative therapeutic approach for the treatment of TMZ-resistant gliomas.
authors.affiliation: Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, United States.
authors.forename: Niyati
authors.initials: N
authors.lastname: Jhaveri
authors.forename: Heeyeon
authors.initials: H
authors.lastname: Cho
authors.forename: Shering
authors.initials: S
authors.lastname: Torres
authors.forename: Weijun
authors.initials: W
authors.lastname: Wang
authors.forename: Axel H
authors.initials: AH
authors.lastname: Schönthal
authors.forename: Nicos A
authors.initials: NA
authors.lastname: Petasis
authors.forename: Stan G
authors.initials: SG
authors.lastname: Louie
authors.forename: Florence M
authors.initials: FM
authors.lastname: Hofman
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Chen
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001932:Brain Neoplasms / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects*; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm; D005260:Female; D005909:Glioblastoma / Q000473:pathology*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009665:Noscapine / Q000494:pharmacology*; D000077204:Temozolomide; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D003606:Dacarbazine; D009665:Noscapine; D000077204:Temozolomide