title: Inferior parietal lobule volume and schneiderian first-rank symptoms in antipsychotic-naïve schizophrenia: a 3-tesla MRI study.
abstract: BACKGROUND
  As per Frith's neuro-cognitive model, inferior parietal lobule (IPL) is implicated in the pathogenesis of Schneiderian first-rank symptoms (FRS) in schizophrenia. The specific role of IPL structural abnormalities in the pathogenesis of FRS is yet to be ascertained.
  
  
  METHODS
  Using 3-tesla MRI scanner, this first-time study examined antipsychotic-naïve schizophrenia patients ( n = 28) (patients with FRS [FRS +]: N = 14, M: F = 7:7; and patients without FRS [FRS-]: N = 14, M: F = 7:7) in comparison with sex-, handedness-, education- and socioeconomic status-matched healthy controls (n = 14, M: F = 7:7). The volume of IPL was measured using a three-dimensional, interactive, semi-automated analysis, with good inter-rater reliability.
  
  
  RESULTS
  FRS + patients showed significant volume deficit in right IPL in comparison with healthy controls (F = 4.0; P=.028) after controlling for the potential confounding effects of age, sex and intracranial volume.
  
  
  CONCLUSIONS
  Right IPL volume deficit in FRS+patients adds further support to the Frith's model of FRS in schizophrenia.
authors.affiliation: Department of Psychiatry, National Institute of Mental Health and Neurosciences [NIMHANS], Bangalore, India.
authors.forename: Vijay
authors.initials: V
authors.lastname: Danivas
authors.forename: Sunil
authors.initials: S
authors.lastname: Kalmady
authors.forename: Rashmi
authors.initials: R
authors.lastname: Arasappa
authors.forename: Rishikesh V
authors.initials: RV
authors.lastname: Behere
authors.forename: Naren P
authors.initials: NP
authors.lastname: Rao
authors.forename: Ganesan
authors.initials: G
authors.lastname: Venkatasubramanian
authors.forename: B N
authors.initials: BN
authors.lastname: Gangadhar