title: Biyoulactones A-C, new pentacyclic meroterpenoids from Hypericum chinense.
abstract: Three novel pentacyclic meroterpenoids with a unique dilactone structure containing C-C bonded bi- and tricyclic γ-lactone moieties, biyoulactones A-C (1-3), were isolated from the roots of Hypericum chinense, and their structures were elucidated on the basis of spectroscopic data. The relative and absolute stereochemistry of 1 was assigned by a combination of NOESY and a single crystal X-ray diffraction analysis.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
authors.forename: Naonobu
authors.initials: N
authors.lastname: Tanaka
authors.forename: Shuhei
authors.initials: S
authors.lastname: Abe
authors.forename: Kimiko
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Motoo
authors.initials: M
authors.lastname: Shiro
authors.forename: Jun'ichi
authors.initials: J
authors.lastname: Kobayashi
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020902:Hypericum / Q000737:chemistry*; D007624:KB Cells; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D013729:Terpenes; C568323:biyoulactone A; C568324:biyoulactone B; C568325:biyoulactone C