title: Comparative study of the intravenous chemoprophylaxix versus local Sulmycin® Implant E Sponge use in vaginal hysterectomy.
abstract: OBJECTIVE
  The aim of this comparative study was to ascertain the efficacy of the Sulmycin® Implant E, an antiseptic sponge, on the incidence of peri- and postoperative morbidity in patients subjected to vaginal hysterectomy.
  
  
  METHODS
  This eleven-year study included 228 patients undergoing vaginal hysterectomy. The patients were divided into two groups. Group A included 169 participants with benign diseases (fibroids, dysfunctional uterine bleeding and prolapse) and group B included 59 patients with early stage endometrial cancer or atypical hyperplasia. Women of both groups were further divided into three subgroups: (a) receiving a single dose of intravenous cefuroxime (2 gr) (group A: 55, group B: 19), (b) receiving three doses of intravenous cefuroxime (2 gr) (group A: 54, group B: 19), and (c) locally placed a collagen sponge containing gentamycin (Sulmycin® Implant E) (group A: 60, group B: 21).
  
  
  RESULTS
  The number of postoperative infections (mainly urinary tract infections) did not differ between women of the three subgroups of patients in both groups. There were no important differences affecting the postoperative hospitalization, healing procedure and adhesion of the cuff between women of the three subgroups in both groups.
  
  
  CONCLUSIONS
  The local chemoprophylaxis with Sulmycin® Implant E, a collagen sponge containing gentamycin and placed on the vaginal cuff, is well tolerated and equally effective as intravenous antibiotics.
authors.affiliation: Department of Obstetrics and Gynaecology, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece. ptsikour@med.duth.gr
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Tsikouras
authors.forename: Alexandros
authors.initials: A
authors.lastname: Dafopoulos
authors.forename: Christos
authors.initials: C
authors.lastname: Zografou
authors.forename: Artemis
authors.initials: A
authors.lastname: Karkanaki
authors.forename: Evelin
authors.initials: E
authors.lastname: Tsigga
authors.forename: Alexandros
authors.initials: A
authors.lastname: Ammari
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Dafopoulos
authors.forename: Georgios
authors.initials: G
authors.lastname: Galazios
authors.forename: Vasileios
authors.initials: V
authors.lastname: Liberis
authors.forename: Alexander Tobias
authors.initials: AT
authors.lastname: Teichmann
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D002444:Cefuroxime / Q000008:administration & dosage / Q000627:therapeutic use*; D003094:Collagen / Q000008:administration & dosage*; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage*; D006801:Humans; D007045:Hysterectomy, Vaginal / Q000379:methods*; D007262:Infusions, Intravenous; D008875:Middle Aged; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; C049880:sulmycin-implant; D003094:Collagen; D002444:Cefuroxime