title: Using hyperpolarized 3He MRI to evaluate treatment efficacy in cystic fibrosis patients.
abstract: OBJECTIVE
  To use hyperpolarized (HP) (3)He MR imaging to assess functional lung ventilation in subjects with cystic fibrosis (CF) before and after treatment.
  
  
  METHODS
  We performed HP (3)He static ventilation MRI scans on three subjects, using a Philips 3.0 Tesla (T) Achieva MRI scanner, before and after 11 days of in-patient treatment with combined intravenous and inhaled therapies for pulmonary exacerbations of CF. We also collected spirometry data. We quantified pulmonary ventilation volume measured with HP (3)He MRI using an advanced semi-automated analysis technique.
  
  
  RESULTS
  Following 11 days of treatment with intravenous antibiotics, hypertonic saline, and rhDNase, HP (3)He MR images in one subject displayed a 25% increase in total ventilation volume. Total ventilation volume in the other two subjects slightly decreased. All three subjects showed increases in FEV(1) and FVC following treatment.
  
  
  CONCLUSIONS
  In all subjects, the HP (3)He MR images provided detailed information on precisely where in the lungs gas was reaching. These data provide additional support for the conclusion that HP noble gas MRI can be a powerful tool for evaluating lung ventilation in patients with cystic fibrosis, but also raise important questions about the correlation between spirometry and HP gas MRI measurements.
authors.affiliation: Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Sun
authors.forename: Brian P
authors.initials: BP
authors.lastname: O'Sullivan
authors.forename: John P
authors.initials: JP
authors.lastname: Roche
authors.forename: Ronn
authors.initials: R
authors.lastname: Walvick
authors.forename: Austin
authors.initials: A
authors.lastname: Reno
authors.forename: Dawn
authors.initials: D
authors.lastname: Baker
authors.forename: Joey K
authors.initials: JK
authors.lastname: Mansour
authors.forename: Mitchell S
authors.initials: MS
authors.lastname: Albert
mesh_terms: D000293:Adolescent; D000328:Adult; D003550:Cystic Fibrosis / Q000473:pathology* / Q000628:therapy; D003851:Deoxyribonucleases / Q000737:chemistry; D005260:Female; D005541:Forced Expiratory Volume; D005740:Gases; D006371:Helium / Q000737:chemistry*; D006801:Humans; D008168:Lung / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D012129:Respiratory Function Tests / Q000379:methods; D013147:Spirometry / Q000379:methods; D014797:Vital Capacity
chemical_list: D005740:Gases; D006371:Helium; D003851:Deoxyribonucleases