title: Domino reaction to functionalized 2-hydroxybenzophenones from electron-deficient chromones and 1,3-dicarbonyl compounds.
abstract: A base-promoted one-pot tandem reaction sequence has been developed to transform electron-deficient chromone-fused dienes 1 and 1,3-dicarbonyl compounds 2 to functionalized 2-hydroxybenzophenones 3 under mild conditions. This domino process, which involves multiple reactions, including Michael addition/cyclization/elimination, serves as an efficient, economic, and eco-friendly method for the construction of diversified 2-hydroxybenzophenone scaffolds without a transition-metal catalyst and inert atmosphere.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, People's Republic of China.
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.forename: Fuchun
authors.initials: F
authors.lastname: Xie
authors.forename: Jian
authors.initials: J
authors.lastname: Gong
authors.forename: Youhong
authors.initials: Y
authors.lastname: Hu
mesh_terms: D001577:Benzophenones / Q000032:analysis* / Q000138:chemical synthesis*; D002254:Carbonates / Q000737:chemistry*; D002384:Catalysis; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002867:Chromones / Q000737:chemistry*; D003500:Cyclization; D004583:Electrons; D055772:Green Chemistry Technology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001577:Benzophenones; D002254:Carbonates; D002867:Chromones; C562127:ortho-hydroxybenzophenone