title: [Malignancy cases in HIV-positive patients in Lodz region in years 1992-2010].
abstract: Cancers are increasingly recognized as a complication of HIV infection. The traditional AIDS defining cancers (ADCs), including Kaposi sarcoma, cervical cancer, and non-Hodgkin's lymphoma, are common in HIV-positive individuals. However, in the period of antiretroviral therapy the incidence of non-AIDS-defining cancers (NADCs) has increased significantly. The aim of this study was to review the incidence and outcomes of cancers in HIV-infected patients.
  
  
  METHODS
  Age, sex and CD 4 cells count at the moment of cancer diagnose were assessed.
  
  
  RESULTS
  From 1992 to 2010 year cancers were diagnosed in 30 patients (one patient has two malignancies simultaneously). In study group ADCs were seen in 21 patients (68%) while NADCs were observed in 10 patients (32%). Mean age at the time of diagnose of ADCs and NADCs was 41.9 and 46.6 years, respectively. Mean CD4 cells count at the time of cancer diagnose of ADCs and NADCs was 177.5 and 201,0 cells/microL, respectively. The most common ADCs was non-Hodgkin's lymphoma and NADCs was lung cancer. In presented study only in 10 patients (33%) full remission of malignancy was reported.
  
  
  CONCLUSIONS
  ADCs are common group of cancers. Nowadays, in period of antiretroviral therapy NADCs are increasingly problem. The cancer-related mortality in HIV-positive patients is still significant.
authors.affiliation: Klinika Chorób Zakaźnych i Hepatologii UM w Łodzi.
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Jabłonowska
authors.forename: Ewa
authors.initials: E
authors.lastname: Małolepsza
authors.forename: Marta
authors.initials: M
authors.lastname: Strycharz
authors.forename: Kamila
authors.initials: K
authors.lastname: Wójcik
mesh_terms: D000328:Adult; D000368:Aged; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology; D006679:HIV Seropositivity; D006689:Hodgkin Disease / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D016483:Lymphoma, AIDS-Related / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology* / Q000276:immunology; D011044:Poland / Q000453:epidemiology; D012042:Registries / Q000706:statistics & numerical data*; D012307:Risk Factors; D012514:Sarcoma, Kaposi / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology