title: [Subchondral bone in osteoarthritis: a review].
abstract: Osteoarthritis (OA) is the most prevalent of joint diseases,and its pathology is characterized by the degeneration of cartilage, sclerosis of subchondral bone, and osteophyte formation. Localization of the early lesions of OA has not been clarified, but many researchers have focused on cartilage and have considered that changes in subchondral bone occur subsequently to the degeneration of cartilage. However, a low bone mineral density, particularly in the knee joint with OA, high bone turnover, and efficacy of bone resorption inhibitors for OA have recently been reported, suggesting that subchondral bone plays an important role in the pathogenesis of OA. This review aims to make a conclusion about advancement in research of subchondral bone in osteoarthritis.
authors.affiliation: Medical Center of Shi Trauma, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. lidazul@126.com
authors.forename: Jian
authors.initials: J
authors.lastname: Pang
authors.forename: Yue-long
authors.initials: YL
authors.lastname: Cao
authors.forename: Yin-yu
authors.initials: YY
authors.lastname: Shi
mesh_terms: D016723:Bone Remodeling; D001842:Bone and Bones / Q000473:pathology*; D002356:Cartilage / Q000473:pathology*; D006801:Humans; D010003:Osteoarthritis / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology