title: Gastrointestinal stromal tumor of the rectum: report of three cases.
abstract: Gastrointestinal stromal tumors (GISTs) account for about 0.2% of all malignancy of gastrointestinal tumors and rarely arise in the rectum. We experienced three patients with large GISTs in the rectum. Case 1 (66-year-old man) underwent abdominoperineal resection (APR) for intrapelvic mass. The tumor was 90 mm and diagnosed to be a Kit-positive GIST. Case 2 (81-year-old woman) underwent right hemicolectomy for concurrent ascending colon cancer by a local physician. In our Hospital, APR was performed for intrapelvic mass. The tumor was 90 mm and diagnosed to be a Kit-positive GIST. Ten months after surgery, multiple liver tumors developed. She received oral imatinib for metastases. Case 3 (83-year-old woman) was yielded a diagnosis of Kit-positive GIST by a percutaneous biopsy. Imatinib was given preoperatively. However, adverse reactions occurred and the drug was withdrawn. APR was performed. The tumor was 70 mm. At present, Case 1 and 3 patients are alive without recurrence.
authors.affiliation: Department of Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. tsuzuki@is.icc.u-tokai.ac.jp
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Suzuki
authors.forename: Sotaro
authors.initials: S
authors.lastname: Sadahiro
authors.forename: Akira
authors.initials: A
authors.lastname: Tanaka
authors.forename: Kazutake
authors.initials: K
authors.lastname: Okada
authors.forename: Hiroko
authors.initials: H
authors.lastname: Okamura
authors.forename: Takashi
authors.initials: T
authors.lastname: Machida
authors.forename: Nobue
authors.initials: N
authors.lastname: Kumaki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D008297:Male; D012004:Rectal Neoplasms / Q000473:pathology* / Q000601:surgery*; D016896:Treatment Outcome