title: Translational and clinical applications of salivary diagnostics.
abstract: There have been significant advances in techniques for the detection of biomarker signals in the oral cavity (e.g., ELISAs for proteins, PCR for RNA and DNA) as well as the engineering and development of microfluidic approaches to make oral-based point-of-care (POC) methods for the diagnosis for both local and systemic conditions a reality. In this section, we focus on three such approaches, namely, periodontal disease management, early markers for systemic diseases, and salivary markers useful for pharmacogenomic studies. Novel approaches using non-invasive, salivary samples and user-friendly devices offer results that are as sensitive and specific as laboratory-based analyses using blood or urine.
authors.affiliation: Department of Periodontics, Michigan Center for Oral Health Research, University of Michigan School of Dentistry, Ann Arbor, USA.
authors.forename: W V
authors.initials: WV
authors.lastname: Giannobile
authors.forename: J T
authors.initials: JT
authors.lastname: McDevitt
authors.forename: R S
authors.initials: RS
authors.lastname: Niedbala
authors.forename: D
authors.initials: D
authors.lastname: Malamud
mesh_terms: D015415:Biomarkers; D002318:Cardiovascular Diseases / Q000175:diagnosis; D019963:Clinical Chemistry Tests / Q000379:methods; D003945:Diagnosis, Oral / Q000379:methods*; D005820:Genetic Testing; D006801:Humans; D056656:Lab-On-A-Chip Devices; D044085:Microfluidics / Q000295:instrumentation; D010518:Periodontitis / Q000175:diagnosis; D010597:Pharmacogenetics; D019095:Point-of-Care Systems; D012463:Saliva / Q000737:chemistry*; D057170:Translational Research, Biomedical
chemical_list: D015415:Biomarkers