title: A general synthesis of dirhodium metallopeptides as MDM2 ligands.
abstract: A synthesis of multifunctional dirhodium metallopeptide ligands for MDM2 is presented. An orthogonal protection scheme of palladium-catalyzed de-allylation on a metallopeptide substrate allows specific dirhodium incorporation in a complex peptide. Sequence effects on MDM2 binding are discussed.
authors.affiliation: Department of Chemistry, Rice University, 6100 Main St., MS60, Houston, TX 77005, USA.
authors.forename: Alexander N
authors.initials: AN
authors.lastname: Zaykov
authors.forename: Zachary T
authors.initials: ZT
authors.lastname: Ball
mesh_terms: D000595:Amino Acid Sequence; D008024:Ligands; D008958:Models, Molecular; D015335:Molecular Probes / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D051736:Proto-Oncogene Proteins c-mdm2 / Q000737:chemistry / Q000378:metabolism*; D012238:Rhodium / Q000737:chemistry*
chemical_list: D008024:Ligands; D015335:Molecular Probes; D010455:Peptides; D012238:Rhodium; D051736:Proto-Oncogene Proteins c-mdm2