title: Synthesis and activity of the archazolid western hemisphere.
abstract: A convergent and scalable synthesis of the archazolid western hemisphere has been completed. The V-ATPase inhibitory activity of this compound along with a previously prepared eastern domain was then tested using a convenient Arabidopsis-based V-ATPase assay.
authors.affiliation: Department of Chemistry, Western Washington University, Bellingham, WA, USA.
authors.forename: Ann B
authors.initials: AB
authors.lastname: Tran
authors.forename: Geoffrey C
authors.initials: GC
authors.lastname: Melly
authors.forename: Ryan
authors.initials: R
authors.lastname: Doucette
authors.forename: Brook
authors.initials: B
authors.lastname: Ashcraft
authors.forename: Leanne J
authors.initials: LJ
authors.lastname: Sebren
authors.forename: Nathan
authors.initials: N
authors.lastname: Havko
authors.forename: Jeffery C
authors.initials: JC
authors.lastname: Young
authors.forename: Gregory W
authors.initials: GW
authors.lastname: O'Neil
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D017360:Arabidopsis / Q000187:drug effects / Q000378:metabolism; D001681:Biological Assay; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D018942:Macrolides / Q000138:chemical synthesis* / Q000494:pharmacology; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D048328:Potoroidae; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D025262:Vacuolar Proton-Translocating ATPases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014617:Vacuoles / Q000187:drug effects* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D018942:Macrolides; D013844:Thiazoles; C519727:archazolid A; C519728:archazolid B; D025262:Vacuolar Proton-Translocating ATPases