title: Do Thyroid Disrupting Chemicals Influence Foetal Development during Pregnancy?
abstract: Maternal euthyroidism during pregnancy is crucial for normal development and, in particular, neurodevelopment of the foetus. Up to 3.5 percent of pregnant women suffer from hypothyroidism. Industrial use of various chemicals-endocrine disrupting chemicals (EDCs)-has been shown to cause almost constant exposure of humans with possible harmful influence on health and hormone regulation. EDCs may affect thyroid hormone homeostasis by different mechanisms, and though the effect of each chemical seems scarce, the added effects may cause inappropriate consequences on, for example, foetal neurodevelopment. This paper focuses on thyroid hormone influence on foetal development in relation to the chemicals suspected of thyroid disrupting properties with possible interactions with maternal thyroid homeostasis. Knowledge of the effects is expected to impact the general debate on the use of these chemicals. However, more studies are needed to elucidate the issue, since human studies are scarce.
authors.affiliation: Department of Medical Endocrinology PE-2131, Rigshospitalet, University Hospital of Copenhagen, 2100 Copenhagen, Denmark.
authors.forename: Marie-Louise
authors.initials: ML
authors.lastname: Hartoft-Nielsen
authors.forename: Malene
authors.initials: M
authors.lastname: Boas
authors.forename: Sofie
authors.initials: S
authors.lastname: Bliddal
authors.forename: Aase Krogh
authors.initials: AK
authors.lastname: Rasmussen
authors.forename: Katharina
authors.initials: K
authors.lastname: Main
authors.forename: Ulla
authors.initials: U
authors.lastname: Feldt-Rasmussen