title: Implication of miRNA in the diagnosis and treatment of breast cancer.
abstract: Breast cancer (BC) comprises a group of different diseases characterized by changes in tissue structure and gene expression. Recent advances in molecular biology have shed new light on the participation of genes and their products in the biology of BC. MicroRNAs (miRNAs) are small noncoding endogenous RNA molecules that appear to modulate the expression of more than a third of human genes, and their implications in cancer have grasped the attention of the scientific community. Recently, several studies have described the association between miRNA expression profiles and pathological and clinical BC features. Moreover, these molecules represent a new type of molecular marker that can identify prognosis and guide the management of BC patients. With the increasing understanding of miRNA networks and their impact in the biology of BC, as well as the development of viable strategies to modulate specific miRNAs, we could improve the treatment of this disease.
authors.affiliation: Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Castañeda
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Agullo-Ortuño
authors.forename: Juan Angel
authors.initials: JA
authors.lastname: Fresno Vara
authors.forename: Hernan
authors.initials: H
authors.lastname: Cortes-Funes
authors.forename: Henry L
authors.initials: HL
authors.lastname: Gomez
authors.forename: Eva
authors.initials: E
authors.lastname: Ciruelos
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000235:genetics*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000037:antagonists & inhibitors* / Q000502:physiology*
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D035683:MicroRNAs