title: Renin is activated in monochorionic diamniotic twins with birthweight discordance who do not have twin-to-twin transfusion syndrome.
abstract: OBJECTIVE
  To assess renin, aldosterone, human atrial natriuretic peptide (hANP) and brain natriuretic peptide (BNP) levels in cord blood from monochorionic diamniotic (MD) twins with a birthweight (BW) discordance that do not satisfy the criteria of twin-to-twin transfusion syndrome (TTTS).
  
  
  METHODS
  Cord blood samples were obtained from 28 MD twins without TTTS. They were divided into two groups on the basis of BW discordance as follows: large (>7.5%) and small (7.5%). Cord blood renin, aldosterone, hANP and BNP levels were measured.
  
  
  RESULTS
  Renin levels in MD twins with a large BW discordance were significantly higher than those in MD twins with a small BW discordance, with no significant differences in aldosterone, hANP and BNP levels. A significant correlation was found between renin levels and BW discordance.
  
  
  CONCLUSIONS
  Renin is activated in MD twins with a BW discordance of >7.5%, even in non-TTTS.
authors.affiliation: Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Fujioka
authors.forename: I
authors.initials: I
authors.lastname: Morioka
authors.forename: A
authors.initials: A
authors.lastname: Miwa
authors.forename: T
authors.initials: T
authors.lastname: Yokota
authors.forename: K
authors.initials: K
authors.lastname: Matsuo
authors.forename: S
authors.initials: S
authors.lastname: Morikawa
authors.forename: M
authors.initials: M
authors.lastname: Enomoto
authors.forename: A
authors.initials: A
authors.lastname: Shibata
authors.forename: M
authors.initials: M
authors.lastname: Morizane
authors.forename: N
authors.initials: N
authors.lastname: Yokoyama
authors.forename: H
authors.initials: H
authors.lastname: Yamada
authors.forename: M
authors.initials: M
authors.lastname: Matsuo
mesh_terms: D000450:Aldosterone / Q000097:blood; D000650:Amnion; D009320:Atrial Natriuretic Factor / Q000097:blood; D001724:Birth Weight; D002823:Chorion; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005330:Fetofetal Transfusion / Q000097:blood; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood; D011247:Pregnancy; D012083:Renin / Q000097:blood*; D014427:Twins; D014430:Twins, Monozygotic
chemical_list: D020097:Natriuretic Peptide, Brain; D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D012083:Renin