title: Regioselective Iodination of Chlorinated Aromatic Compounds Using Silver Salts.
abstract: The iodination of chlorinated aromatic compounds using Ag(2)SO(4)/I(2), AgSbF(6)/I(2), AgBF(4)/I(2) and AgPF(6)/I(2) offers access to iodoarenes that are valuable intermediates in organic synthesis. Specifically, iodination of phenols, anisoles and anilines with a 3,5-dichloro substitution pattern preferentially yielded the ortho, para and para iodinated product, respectively. In the case of chlorobenzene and 3-chlorotoluene, AgSbF(6)/I(2), AgBF(4)/I(2) and AgPF(6)/I(2), but not Ag(2)SO(4)/I(2), selectively introduced the iodine in para position to the chlorine substituent.
authors.affiliation: The University of Iowa, Department of Occupational and Environmental Health, University of Iowa Research Park, 124 IREH, Iowa City, IA 52242, USA.
authors.forename: Sudhir N
authors.initials: SN
authors.lastname: Joshi
authors.forename: Sandhya M
authors.initials: SM
authors.lastname: Vyas
authors.forename: Huimin
authors.initials: H
authors.lastname: Wu
authors.forename: Michael W
authors.initials: MW
authors.lastname: Duffel
authors.forename: Sean
authors.initials: S
authors.lastname: Parkin
authors.forename: Hans-Joachim
authors.initials: HJ
authors.lastname: Lehmler