title: Increased serum levels of uric acid are associated with sudomotor dysfunction in subjects with type 2 diabetes mellitus.
abstract: The aim of this paper was to assess serum uric acid (SUA) levels in patients with type 2 diabetes mellitus (T2DM) with or without sudomotor dysfunction (evaluated by the Neuropad test). We included 36 T2DM patients with sudomotor dysfunction (group A: mean age 63.1 ± 2.6 years) and 40 age-, gender-, renal function- and T2DM duration-matched patients without sudomotor dysfunction (group B: mean age 62.1 ± 3.1 years). SUA was significantly higher in group A (P < 0.001). There was a significant correlation between SUA and Neuropad time to colour change in both groups (group A: r(s) = 0.819, P < 0.001; group B: r(s) = 0.774, P < 0.001). There was also a significant positive correlation between SUA and CRP in both groups (group A: r(s) = 0.947, P < 0.001; group B: r(s) = 0.848, P < 0.001). In conclusion, SUA levels were higher in T2DM patients with sudomotor dysfunction than those without this complication. The potential role of SUA in sudomotor dysfunction merits further study.
authors.affiliation: Outpatient Clinic of Obesity, Diabetes, and Metabolism, Second Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis, Greece. papanasnikos@yahoo.gr
authors.forename: N
authors.initials: N
authors.lastname: Papanas
authors.forename: M
authors.initials: M
authors.lastname: Demetriou
authors.forename: N
authors.initials: N
authors.lastname: Katsiki
authors.forename: K
authors.initials: K
authors.lastname: Papatheodorou
authors.forename: D
authors.initials: D
authors.lastname: Papazoglou
authors.forename: T
authors.initials: T
authors.lastname: Gioka
authors.forename: S
authors.initials: S
authors.lastname: Kotsiou
authors.forename: E
authors.initials: E
authors.lastname: Maltezos
authors.forename: D P
authors.initials: DP
authors.lastname: Mikhailidis
mesh_terms: D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications*; D003929:Diabetic Neuropathies / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000503:physiopathology; D013542:Sweat / Q000378:metabolism; D013546:Sweating / Q000502:physiology*; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid