title: Reduced microbial attachment by D-amino acid-inhibited AI-2 and EPS production.
abstract: This study investigated the effect of D-tyrosine on microbial attachment to hydrophilic glass and hydrophobic polypropylene surfaces. Results showed that D-tyrosine did not influence microbial growth, ATP and substrate utilization, but significantly inhibited the synthesis of autoinducer-2 (AI-2), eDNA and extracellular polysaccharides and proteins, and subsequently reduced microbial attachment onto glass and polypropylene surfaces was observed. It was shown that D-amino acid would be a non-toxic agent for control of microbial attachment.
authors.affiliation: Division of Environmental and Water Resources Engineering, School of Civil and Environmental Engineering, Nanyang Technological University, Singapore, Singapore.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Xu
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development; D001422:Bacterial Adhesion / Q000187:drug effects*; D001426:Bacterial Proteins / Q000378:metabolism; D001704:Biopolymers / Q000096:biosynthesis*; D002244:Carbon / Q000032:analysis; D002850:Chromatography, Gel; D004269:DNA, Bacterial / Q000378:metabolism; D005110:Extracellular Space; D006714:Homoserine / Q000031:analogs & derivatives* / Q000096:biosynthesis; D007783:Lactones; D018613:Microscopy, Confocal; D011135:Polysaccharides, Bacterial / Q000378:metabolism; D014443:Tyrosine / Q000494:pharmacology*
chemical_list: D001426:Bacterial Proteins; D001704:Biopolymers; D004269:DNA, Bacterial; D007783:Lactones; C091088:N-octanoylhomoserine lactone; D011135:Polysaccharides, Bacterial; D014443:Tyrosine; D006714:Homoserine; D002244:Carbon; D000255:Adenosine Triphosphate