title: Stability of [(N-morpholine)metylene]daunorubicin hydrochloride in solid state.
abstract: The influence of temperature and relative air humidity on the stability of the novel derivative of daunorubicin: [(N-morpholine)metylene]daunorubicin hydrochloride was investigated. The process of degradation was studied by using high-performance liquid chromatography with ultraviolet (UV) detection. In dry air, the degradation of [(N-morpholine)metylene]daunorubicin hydrochloride was a first-order reaction depending on the substrate concentration, while at relative air humidity from 60.5 to 90.0% it was an autocatalytic reaction of the first order with respect to MMD concentration. The kinetic and thermodynamic parameters of degradation were calculated.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Poznaxi University of Medical Sciences, 6 Grunwaldzka St., 60-780 Poznań, Poland pzalewski@ump.edu.pl
authors.forename: Przemysław
authors.initials: P
authors.lastname: Zalewski
authors.forename: Anna
authors.initials: A
authors.lastname: Jelińska
authors.forename: Patrycja
authors.initials: P
authors.lastname: Prusinowska
authors.forename: Judyta
authors.initials: J
authors.lastname: Cielecka-Piontek
authors.forename: Anna
authors.initials: A
authors.lastname: Krause
authors.forename: Irena
authors.initials: I
authors.lastname: Oszczapowicz
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000032:analysis; D006813:Humidity; D009025:Morpholines / Q000032:analysis*; D010316:Particle Size; D013696:Temperature; D013816:Thermodynamics
chemical_list: C561665:((N-morpholine)metylene)daunorubicin; D000903:Antibiotics, Antineoplastic; D009025:Morpholines; D003630:Daunorubicin