title: STING-dependent signaling.
abstract: The sensing of pathogen-associated DNA in the cytoplasm is an important trigger of host-defense responses that include the production of type I interferon. A new study suggests that the DExDc helicase DDX41 may function in dendritic cells as a DNA sensor to activate STING-dependent innate immune responses.
authors.forename: Glen N
authors.initials: GN
authors.lastname: Barber
mesh_terms: D000818:Animals; D053487:DEAD-box RNA Helicases / Q000502:physiology*; D004247:DNA / Q000378:metabolism*; D004265:DNA Helicases / Q000502:physiology*; D003713:Dendritic Cells / Q000502:physiology*; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology*; D000099197:STING Protein
chemical_list: D053487:DEAD-box RNA Helicases; D004247:DNA; D004265:DNA Helicases; D008565:Membrane Proteins; C532857:STING1 protein, human; D000099197:STING Protein; C530855:Sting1 protein, mouse; C501226:DDX41 protein, human; C567960:DDX41 protein, mouse