title: Use of botulinum toxin A in management of children with cerebral palsy.
abstract: OBJECTIVE
  What is the role of intramuscular botulinum toxin injections in the management of spasticity and related morbidity in children with cerebral palsy?
  
  
  CONCLUSIONS
  When botulinum toxin A is injected into the limbs of children with spastic paresis, it induces temporary reduction in muscle tone. It also promotes better motor function when used in combination with conservative treatments such as physiotherapy. Although there is a growing body of evidence for its effective and safe treatment, there is still a lack of consensus on dose, treatment regimens, and the best integration with other clinical modalities.
authors.affiliation: BC Children's Hospital, Department of Pediatrics, Vancouver, BC V6H 3V4, Canada.
authors.forename: Bat-Chen
authors.initials: BC
authors.lastname: Friedman
authors.forename: Ran D
authors.initials: RD
authors.lastname: Goldman
mesh_terms: D019274:Botulinum Toxins, Type A / Q000009:adverse effects / Q000627:therapeutic use*; D002547:Cerebral Palsy / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D006801:Humans; D009128:Muscle Spasticity / Q000188:drug therapy*; D009465:Neuromuscular Agents / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A