title: Thrombosis on a Mechanical Aortic Valve whilst Anti-coagulated With Dabigatran.
abstract: There is currently limited evidence on the safety and efficacy of novel oral anticoagulants in patients with mechanical heart valves. This case report describes a patient with a St Jude aortic valve replacement who suffered valve thrombosis and an embolic stroke when anti-coagulated with the direct thrombin inhibitor dabigatran etexilate.
authors.affiliation: Department of Cardiology, Auckland City Hospital, Auckland, New Zealand. rstewart@adhb.govt.nz
authors.forename: Ralph A H
authors.initials: RA
authors.lastname: Stewart
authors.forename: Heather
authors.initials: H
authors.lastname: Astell
authors.forename: Laura
authors.initials: L
authors.lastname: Young
authors.forename: Harvey D
authors.initials: HD
authors.lastname: White
mesh_terms: D001021:Aortic Valve / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D001024:Aortic Valve Stenosis / Q000601:surgery; D001562:Benzimidazoles / Q000008:administration & dosage* / Q000009:adverse effects; D001777:Blood Coagulation / Q000187:drug effects; D000069604:Dabigatran; D004351:Drug Resistance; D017548:Echocardiography, Transesophageal / Q000379:methods; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000009:adverse effects; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D019918:Heart Valve Prosthesis Implantation / Q000295:instrumentation / Q000379:methods; D006801:Humans; D020766:Intracranial Embolism / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D020379:Risk Adjustment; D012720:Severity of Illness Index; D013927:Thrombosis / Q000209:etiology / Q000503:physiopathology; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome; D015091:beta-Alanine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D001562:Benzimidazoles; D005343:Fibrinolytic Agents; D015091:beta-Alanine; D000069604:Dabigatran