title: Controlled formation of peptide bonds in the gas phase.
abstract: Photoexcitation (using 157 nm vacuum ultraviolet radiation) of proton-bound peptide complexes leads to water elimination and the formation of longer amino acid chains. Thus, it appears that proton-bound dimers are long-lived intermediates along the pathway to peptide formation. Product specificity can be controlled by selection of specific complexes and the incorporation of blocking groups at the N- or C-termini. The product peptide sequences are confirmed using collision-induced dissociation.
authors.affiliation: Department of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.
authors.forename: Sunyoung
authors.initials: S
authors.lastname: Lee
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Valentine
authors.forename: James P
authors.initials: JP
authors.lastname: Reilly
authors.forename: David E
authors.initials: DE
authors.lastname: Clemmer
mesh_terms: D000595:Amino Acid Sequence; D019281:Dimerization; D005740:Gases / Q000737:chemistry; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D011522:Protons; D014466:Ultraviolet Rays; D014867:Water / Q000737:chemistry
chemical_list: D005740:Gases; D010455:Peptides; D011522:Protons; D014867:Water