title: Gestational diabetes and subclinical inflammation: evaluation of first year postpartum outcomes.
abstract: OBJECTIVE
  The aim of this study was to evaluate the relationship between sublinical inflammation and glycemic status in patients with gestational diabetes mellitus (GDM).
  
  
  METHODS
  Sixty-one patients with GDM and 40 healthy pregnant women were included in the study. Fasting blood glucose (FBG), insulin, high sensitivity C-reactive protein (hsCRP), lipid parameters and carotid artery intima-media thickness (CIMT) were measured. Fifty-five of the patients with GDM returned for a follow-up visit scheduled at 1-year post-partum. These patients were subjected to 75 g oral glucose tolerance test (OGTT) followed by an evaluation of metabolic and subclinical inflammatory parameters were evaluated.
  
  
  RESULTS
  The mean FBG, insulin, homeostasis model assessment insulin resistance (HOMA-IR), triglyceride (TG), hsCRP levels and CIMT in the women with GDM were significantly higher than those in the control group. C-reactive protein and CIMT were positively correlated with insulin, HOMA-IR, glucose value at the time of the OGTT 50, prepregnancy body mass index, TG and FBG. Multivariate logistic regression analysis on patients with sustained hyperglycemia one-year postpartum revealed elevated hsCRP levels to be independent risk factors for the development of dysglycemia.
  
  
  CONCLUSIONS
  Elevated hsCRP levels could be predictors of progression to T2DM later in life in patients with GDM.
authors.affiliation: Ministry of Health, Ankara Numune Research and Training Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey. uozoguz@yahoo.com.tr
authors.forename: Ufuk
authors.initials: U
authors.lastname: Ozuguz
authors.forename: Serhat
authors.initials: S
authors.lastname: Isik
authors.forename: Dilek
authors.initials: D
authors.lastname: Berker
authors.forename: Ayse
authors.initials: A
authors.lastname: Arduc
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Tutuncu
authors.forename: Gulhan
authors.initials: G
authors.lastname: Akbaba
authors.forename: Ferhat
authors.initials: F
authors.lastname: Gokay
authors.forename: Serdar
authors.initials: S
authors.lastname: Guler
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000209:etiology / Q000473:pathology*; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D048909:Diabetes Complications / Q000209:etiology / Q000473:pathology; D016640:Diabetes, Gestational / Q000097:blood / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D005951:Glucose Tolerance Test; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000209:etiology / Q000473:pathology*; D007333:Insulin Resistance; D049590:Postpartum Period / Q000502:physiology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology / Q000473:pathology; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D017539:Tunica Intima / Q000473:pathology
chemical_list: D001786:Blood Glucose; D002097:C-Reactive Protein