title: Bioactive metabolites from biotransformation of paeonol by the white-rot basidiomycete Coriolus versicolor.
abstract: Biotransformation of paeonol (1) with the white-rot basidiomycete Coriolus versicolor afforded two metabolites, 2,4-dihydroxyacetophenone (2) and 2,5-dihydroxy-4-methoxyacetophenone (3), which were identified by spectroscopic methods. Compound 3 showed higher antioxidative, antibacterial, antifungal activities than 1 or 2. The results demonstrate for the first time that C. versicolor has the capacities to catalyze hydroxylation and demethylation reactions on the aromatic compound.
authors.affiliation: Research Centre for Natural Medicinal Chemistry, College of Science, Northwest A & F University, Yangling, Shaanxi 712100, China.
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Li
authors.forename: Xin-Wei
authors.initials: XW
authors.lastname: Shi
authors.forename: Qi
authors.initials: Q
authors.lastname: Shuai
authors.forename: Jin-Ming
authors.initials: JM
authors.lastname: Gao
authors.forename: An-Ling
authors.initials: AL
authors.lastname: Zhang
mesh_terms: D000098:Acetophenones / Q000737:chemistry* / Q000378:metabolism*; D001487:Basidiomycota / Q000378:metabolism*; D006900:Hydroxylation
chemical_list: C561800:2,5-dihydroxy-4-methoxyacetophenone; D000098:Acetophenones; C013638:paeonol; C078634:2,4-dihydroxyacetophenone