title: [Studying the therapeutic effects of hemoperfusion with continuous venovenous hemofiltration on the patients with acute paraquat poisoning].
abstract: OBJECTIVE
  To explore the therapeutic effects of hemoperfusion (HP) with continuous venovenous hemofiltration (CVVH) on the patients with acute paraquat poisoning.
  
  
  METHODS
  Ninety-one patients with acute paraquat poisoning were randomly divided into HP group (49 cases) and HP-CVVH group (42 cases). The mortality, survival duration and the death causes between the two groups were compared and analyzed.
  
  
  RESULTS
  There were no significant differences in mortality (59.2% versus 61.9%) between the two groups. The mean time between poisoning and death in HP-CVVH group was (4.9 +/- 3.1) days, which was significantly longer than that (3.5 +/- 2.0) days in HP group (P < 0.05). The death proportion on 4th day after poisoning in HP group was 62.1% (18/29), which was significantly higher than that (30.8%, 8/26) in HP-CVVH group (P < 0.05). The hypoxia appeared in 4.3 +/- 2.5 days after poisoning in HP-CVVH group, which was significantly longer than that (3.2 +/- 1.9) days in HP group (P < 0.05). The mortality due to respiratory failure in HP group was 20.4% (10/49), which was significantly lower than that (40.5%, 17/42) in HP-CVVH group (P < 0.05). The incidence of acute renal failure in HP group was 63.3% (31/49), which was significantly higher than that (40.5%, 17/42) in HP-CVVH group (P < 0.05).
  
  
  CONCLUSIONS
  The combined therapy of HP and CVVH can prevent the patients with acute paraquat poisoning from early death and prolong the survival duration, but can not reduce mortality for the patients with acute paraquat poisoning.
authors.affiliation: Department of Emergency Medicine, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.forename: Yue-Zhong
authors.initials: YZ
authors.lastname: He
authors.forename: Xi-Gang
authors.initials: XG
authors.lastname: Zhang
authors.forename: Guang
authors.initials: G
authors.lastname: Li
authors.forename: Hao-Chun
authors.initials: HC
authors.lastname: Wang
authors.forename: Xiao-Xia
authors.initials: XX
authors.lastname: Lu
authors.forename: Cheng-Gang
authors.initials: CG
authors.lastname: Zhang
authors.forename: Qing-Yi
authors.initials: QY
authors.lastname: Meng
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006440:Hemofiltration; D006464:Hemoperfusion; D006801:Humans; D008297:Male; D008875:Middle Aged; D010269:Paraquat / Q000506:poisoning*; D011041:Poisoning / Q000401:mortality / Q000628:therapy*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D010269:Paraquat