title: Determination of cut-offs for circulating tumor cell measurement in metastatic cancer.
abstract: The metastatic transformation of epithelial tumors progresses through various steps leading to the generation of circulating tumor cells (CTCs). Measurement of CTCs in the peripheral blood is being increasingly recognized as a promising tool in breast oncology. Several studies have evaluated the prognostic significance of CTCs in newly diagnosed metastatic breast cancer (MBC) patients. The IC 2006-04 was a high-powered, prospective, multicenter, observational study conceived to assess CTC changes in women with MBC treated with first-line chemotherapy. Levels ≥ 5 CTCs/7.5 ml blood at baseline and before the second cycle of treatment were independent prognostic factors associated with shorter progression-free and overall survival. This study provides further level II evidence for the clinical and prognostic value of CTCs in MBC, confirming data from earlier small studies. It also provides proof that CTCs should be investigated in ongoing interventional trials to see if better patient outcomes can be attained by altering treatment based on CTC levels.
authors.affiliation: Dept. of Oncology, Dept. of Surgery and Cancer, 5th Floor, MRC Cyclotron Building, Imperial College, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK.
authors.forename: Jimmy
authors.initials: J
authors.lastname: Jacob
authors.forename: Jonathan
authors.initials: J
authors.lastname: Krell
authors.forename: Leandro
authors.initials: L
authors.lastname: Castellano
authors.forename: Long R
authors.initials: LR
authors.lastname: Jiao
authors.forename: Justin
authors.initials: J
authors.lastname: Stebbing
authors.forename: Adam E
authors.initials: AE
authors.lastname: Frampton