title: Application of a Double Aza-Michael Reaction in a 'Click, Click, Cy-Click' Strategy: From Bench to Flow.
abstract: The development of a 'click, click, cy-click' process utilizing a double aza-Michael reaction to generate functionalized 1,2,5-thiadiazepane 1,1-dioxides is reported. Optimization in flow, followed by scale out of the inter-/intramolecular double aza-Michael addition has also been realized using a microwave-assisted, continuous flow organic synthesis platform (MACOS). In addition, a facile one-pot, sequential strategy employing in situ Huisgen cycloaddition post-double aza-Michael has been accomplished, and is applicable to library synthesis.
authors.affiliation: Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045-7582 and the Center for Chemical Methodologies and Library Development at the University of Kansas (KU-CMLD), 2034 Becker Drive, Delbert M. Shankel Structural Biology Center, Lawrence, KS 66047-3761, USA.
authors.forename: Qin
authors.initials: Q
authors.lastname: Zang
authors.forename: Salim
authors.initials: S
authors.lastname: Javed
authors.forename: Farman
authors.initials: F
authors.lastname: Ullah
authors.forename: Aihua
authors.initials: A
authors.lastname: Zhou
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Knudtson
authors.forename: Danse
authors.initials: D
authors.lastname: Bi
authors.forename: Fatima Z
authors.initials: FZ
authors.lastname: Basha
authors.forename: Michael G
authors.initials: MG
authors.lastname: Organ
authors.forename: Paul R
authors.initials: PR
authors.lastname: Hanson