title: Iodine-catalyzed conjugate addition of indoles onto en-1,4-dione: a novel synthesis of 3-(1-(1H-indol-3-yl)-2-oxo-2-phenylethyl)indolin-2-ones as antibacterial and antifungal agents.
abstract: Indole and its derivatives undergo smooth conjugate addition onto en-1,4-dione derived from isatin and acetophenone, in the presence of a catalytic amount of molecular iodine in acetonitrile under mild conditions to afford a novel class of 3-(1-(1H-indol-3-yl)-2-oxo-2-phenylethyl)indolin-2-one derivatives in good yields with high degree of 1,4-selectivity. Some of these compounds are found to exhibit modest antibacterial and antifungal properties.
authors.affiliation: Organic Chemistry Division-1, Indian Institute of Chemical Technology, Hyderabad 500 007, India. basireddy@iict.res.in
authors.forename: B V Subba
authors.initials: BV
authors.lastname: Reddy
authors.forename: N
authors.initials: N
authors.lastname: Rajeswari
authors.forename: M
authors.initials: M
authors.lastname: Sarangapani
authors.forename: G
authors.initials: G
authors.lastname: Roopa Reddy
authors.forename: Ch
authors.initials: Ch
authors.lastname: Madan
authors.forename: K
authors.initials: K
authors.lastname: Pranay Kumar
authors.forename: M
authors.initials: M
authors.lastname: Srinivasa Rao
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology; D002384:Catalysis; D007211:Indoles / Q000737:chemistry*; D007455:Iodine / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007211:Indoles; D007455:Iodine