title: Scalable synthesis of (1-cyclopropyl)cyclopropylamine hydrochloride.
abstract: 1-Cyclopropylcyclopropanecarboxylic acid (2), which is accessible on a large scale (900 mmol) from 1-bromo-1-cyclopropylcyclopropane (1) in 64% yield (89% on a 12.4 mmol scale), has been subjected to a Curtius degradation employing the Weinstock protocol to furnish the N-Boc-protected (1-cyclopropyl)cyclopropylamine 3 (76%). Deprotection of 3 with hydrogen chloride in diethyl ether gave the (1-cyclopropyl)cyclopropylamine hydrochloride (4·HCl) in 87% yield.
authors.affiliation: Institut für Organische und Biomolekulare Chemie der Georg-August-Universität Göttingen, Tammannstrasse 2, 37077 Göttingen, Germany.
authors.forename: Sergei I
authors.initials: SI
authors.lastname: Kozhushkov
authors.forename: Alexander F
authors.initials: AF
authors.lastname: Khlebnikov
authors.forename: Rafael R
authors.initials: RR
authors.lastname: Kostikov
authors.forename: Dmitrii S
authors.initials: DS
authors.lastname: Yufit
authors.forename: Armin
authors.initials: A
authors.lastname: de Meijere