title: Cellular functions of class IX myosins in epithelia and immune cells.
abstract: Mammals contain two class IX myosins, Myo9a and Myo9b. They are actin-based motorized signalling molecules that negatively regulate RhoA signalling. Myo9a has been implicated in the regulation of epithelial cell morphology and differentiation, whereas Myo9b has been shown to play an important role in the regulation of macrophage shape and motility.
authors.affiliation: Institute of Molecular Cell Biology, Westfalian Wilhelms University Münster, 48149 Münster, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Bähler
authors.forename: Kerstin
authors.initials: K
authors.lastname: Elfrink
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Hanley
authors.forename: Sabine
authors.initials: S
authors.lastname: Thelen
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002465:Cell Movement; D048430:Cell Shape; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D008264:Macrophages / Q000166:cytology / Q000378:metabolism*; D009218:Myosins / Q000235:genetics / Q000378:metabolism*; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism*
chemical_list: C120896:MYO9A protein, human; D020033:Protein Isoforms; C113469:myosin IXB; D009218:Myosins