title: A potent antitumor Zn2+ tetraazamacrocycle complex targeting DNA: the fluorescent recognition, interaction and apoptosis studies.
abstract: A Zn(2+) tetraazamacrocycle complex (2) bearing three naphthalene moieties has been prepared. Complex 2 recognizes, binds and causes damage to DNA, and shows considerable cytotoxicity against human cervical (HeLa), breast (MCF-7) and lung (NCI-H157) cancer cell lines with a different apoptotic pathway from that of cisplatin.
authors.affiliation: State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China.
authors.forename: Jing-Han
authors.initials: JH
authors.lastname: Wen
authors.forename: Cheng-Ying
authors.initials: CY
authors.lastname: Li
authors.forename: Zhi-Rong
authors.initials: ZR
authors.lastname: Geng
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Ma
authors.forename: Zhi-Lin
authors.initials: ZL
authors.lastname: Wang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D004247:DNA / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D047028:Macrocyclic Compounds / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D013050:Spectrometry, Fluorescence; D015032:Zinc / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D047028:Macrocyclic Compounds; D009942:Organometallic Compounds; D004247:DNA; D015032:Zinc