title: Ribosomal mutations as the main cause of macrolide resistance in Campylobacter jejuni and Campylobacter coli.
abstract: The aim of this study was to examine macrolide resistance mutations in Campylobacter species. In 76 strains studied, point mutation A to G at position 2059 of the 23S rRNA gene was detected in 30 of the 33 erythromycin-resistant strains. An amino acid insertion in the ribosomal protein L22 was found in one resistant strain without a 23S rRNA mutation. The A2059G mutation is the main cause of macrolide resistance in Campylobacter species.
authors.affiliation: Antimicrobial Resistance Unit, National Institute for Health and Welfare, THL, Kiinamyllynkatu 13, 20520 Turku, Finland. mipleht@utu.fi
authors.forename: Mirva
authors.initials: M
authors.lastname: Lehtopolku
authors.forename: Pirkko
authors.initials: P
authors.lastname: Kotilainen
authors.forename: Marjo
authors.initials: M
authors.lastname: Haanperä-Heikkinen
authors.forename: Ulla-Maija
authors.initials: UM
authors.lastname: Nakari
authors.forename: Marja-Liisa
authors.initials: ML
authors.lastname: Hänninen
authors.forename: Pentti
authors.initials: P
authors.lastname: Huovinen
authors.forename: Anja
authors.initials: A
authors.lastname: Siitonen
authors.forename: Erkki
authors.initials: E
authors.lastname: Eerola
authors.forename: Jari
authors.initials: J
authors.lastname: Jalava
authors.forename: Antti J
authors.initials: AJ
authors.lastname: Hakanen
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002169:Campylobacter Infections / Q000382:microbiology; D017000:Campylobacter coli / Q000187:drug effects* / Q000235:genetics; D016123:Campylobacter jejuni / Q000187:drug effects* / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D004917:Erythromycin / Q000494:pharmacology; D006801:Humans; D018942:Macrolides / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D017354:Point Mutation / Q000235:genetics*; D012338:RNA, Ribosomal, 23S / Q000235:genetics*; D012269:Ribosomal Proteins / Q000235:genetics; D017422:Sequence Analysis, DNA
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; D012338:RNA, Ribosomal, 23S; D012269:Ribosomal Proteins; D004917:Erythromycin