title: Conservation of Salmonella infection mechanisms in plants and animals.
abstract: Salmonella virulence in animals depends on effectors injected by Type III Secretion Systems (T3SSs). In this report we demonstrate that Salmonella mutants that are unable to deliver effectors are also compromised in infection of Arabidopsis thaliana plants. Transcriptome analysis revealed that in contrast to wild type bacteria, T3SS mutants of Salmonella are compromised in suppressing highly conserved Arabidopsis genes that play a prominent role during Salmonella infection of animals. We also found that Salmonella originating from infected plants are equally virulent for human cells and mice. These results indicate a high degree of conservation in the defense and infection mechanism of animal and plant hosts during Salmonella infection.
authors.affiliation: URGV Plant Genomics, INRA/University of Evry, Evry, France. adam.schikora@agrar.uni-giessen.de
authors.forename: Adam
authors.initials: A
authors.lastname: Schikora
authors.forename: Isabelle
authors.initials: I
authors.lastname: Virlogeux-Payant
authors.forename: Eduardo
authors.initials: E
authors.lastname: Bueso
authors.forename: Ana V
authors.initials: AV
authors.lastname: Garcia
authors.forename: Theodora
authors.initials: T
authors.lastname: Nilau
authors.forename: Amélie
authors.initials: A
authors.lastname: Charrier
authors.forename: Sandra
authors.initials: S
authors.lastname: Pelletier
authors.forename: Pierrette
authors.initials: P
authors.lastname: Menanteau
authors.forename: Manuela
authors.initials: M
authors.lastname: Baccarini
authors.forename: Philippe
authors.initials: P
authors.lastname: Velge
authors.forename: Heribert
authors.initials: H
authors.lastname: Hirt
mesh_terms: D000818:Animals; D017360:Arabidopsis / Q000382:microbiology; D018938:Caco-2 Cells; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D010935:Plant Diseases / Q000235:genetics / Q000382:microbiology; D010944:Plants / Q000382:microbiology*; D012480:Salmonella Infections / Q000235:genetics / Q000378:metabolism* / Q000382:microbiology*; D012481:Salmonella Infections, Animal / Q000235:genetics / Q000378:metabolism* / Q000382:microbiology; D012486:Salmonella typhimurium / Q000472:pathogenicity; D014774:Virulence / Q000235:genetics / Q000502:physiology