title: Does Glycine max leaves or Garcinia Cambogia promote weight-loss or lower plasma cholesterol in overweight individuals: a randomized control trial.
abstract: BACKGROUND
  Natural food supplements with high flavonoid content are often claimed to promote weight-loss and lower plasma cholesterol in animal studies, but human studies have been more equivocal. The aim of this study was firstly to determine the effectiveness of natural food supplements containing Glycine max leaves extract (EGML) or Garcinia cambogia extract (GCE) to promote weight-loss and lower plasma cholesterol. Secondly to examine whether these supplements have any beneficial effect on lipid, adipocytokine or antioxidant profiles.
  
  
  METHODS
  Eighty-six overweight subjects (Male:Female = 46:40, age: 20~50 yr, BMI > 23 < 29) were randomly assigned to three groups and administered tablets containing EGML (2 g/day), GCE (2 g/day) or placebo (starch, 2 g/day) for 10 weeks. At baseline and after 10 weeks, body composition, plasma cholesterol and diet were assessed. Blood analysis was also conducted to examine plasma lipoproteins, triglycerides, adipocytokines and antioxidants.
  
  
  RESULTS
  EGML and GCE supplementation failed to promote weight-loss or any clinically significant change in %body fat. The EGML group had lower total cholesterol after 10 weeks compared to the placebo group (p < 0.05). EGML and GCE had no effect on triglycerides, non-HDL-C, adipocytokines or antioxidants when compared to placebo supplementation. However, HDL-C was higher in the EGML group (p < 0.001) after 10 weeks compared to the placebo group.
  
  
  CONCLUSIONS
  Ten weeks of EGML or GCE supplementation did not promote weight-loss or lower total cholesterol in overweight individuals consuming their habitual diet. Although, EGML did increase plasma HDL-C levels which is associated with a lower risk of atherosclerosis.
authors.affiliation: Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu, Republic of Korea.
authors.forename: Ji-Eun
authors.initials: JE
authors.lastname: Kim
authors.forename: Seon-Min
authors.initials: SM
authors.lastname: Jeon
authors.forename: Ki Hun
authors.initials: KH
authors.lastname: Park
authors.forename: Woo Song
authors.initials: WS
authors.lastname: Lee
authors.forename: Tae-Sook
authors.initials: TS
authors.lastname: Jeong
authors.forename: Robin A
authors.initials: RA
authors.lastname: McGregor
authors.forename: Myung-Sook
authors.initials: MS
authors.lastname: Choi
mesh_terms: D054392:Adipokines / Q000097:blood*; D000410:Alanine Transaminase / Q000097:blood; D000975:Antioxidants / Q000378:metabolism*; D001219:Aspartate Aminotransferases / Q000097:blood; D002784:Cholesterol / Q000097:blood*; D019587:Dietary Supplements; D005260:Female; D029761:Garcinia cambogia; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D050177:Overweight / Q000097:blood / Q000188:drug therapy*; D010936:Plant Extracts / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry; D013025:Glycine max; D015431:Weight Loss / Q000187:drug effects*
chemical_list: D054392:Adipokines; D000975:Antioxidants; D008055:Lipids; D010936:Plant Extracts; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase