title: Innovative cosmeceuticals: sirtuin activators and anti-glycation compounds.
abstract: Skin aging is a combination of natural aging with superimposed photoaging. Naturally aged skin is thin, fragile and finely wrinkled whereas photoaged skin is rough and thickened with deep coarse wrinkles. In addition photoaging is characterized by mottled pigmentation, solar lentigines, telangectasias and a loss of elasticity. The science behind skin aging has exploded in the past decade. Skin aging has now been defined on both a cellular and molecular level. The study of genomics in aging skin provides us with potential targets as points for intervention. In this regard, the science behind skin aging becomes a platform for the development of new anti-aging strategies and products. In this paper two new and emerging approaches to treat aging skin will be discussed. Sirtuin activating and anti-glycation products are already being marketed by cosmetic and pharmaceutical companies. These anti-aging approaches are backed by basic science research and the ingredients used are supported by proof of concept studies although clinical trials are often lacking. It is this bench to beauty counter approach to cosmeceuticals that remains an industry standard today.
authors.affiliation: Tulane University School of Medicine, New Orleans, LA, USA. pkfar@aol.com
authors.forename: Patricia K
authors.initials: PK
authors.lastname: Farris
mesh_terms: D000975:Antioxidants / Q000494:pharmacology; D003358:Cosmetics / Q000737:chemistry / Q000627:therapeutic use*; D020536:Enzyme Activators / Q000494:pharmacology; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D028321:Plant Preparations / Q000494:pharmacology*; D000077185:Resveratrol; D037761:Sirtuins / Q000502:physiology* / Q000627:therapeutic use; D015595:Skin Aging / Q000187:drug effects / Q000502:physiology*; D013267:Stilbenes / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D003358:Cosmetics; D020536:Enzyme Activators; D017127:Glycation End Products, Advanced; D028321:Plant Preparations; D013267:Stilbenes; D037761:Sirtuins; D000077185:Resveratrol