title: Laryngeal allotransplantation by stages in beagles: an initial study.
abstract: OBJECTIVE
  To establish a model of cynolaryngeal transplantation.
  
  
  METHODS
  Ten beagles, matched for weight (8-10 kg) were divided into five groups for allotransplantation. The vascular circulation was managed with an end-to-end or end-to-lateral anastomosis of allograft bilateral common carotid arteries to recipient bilateral common carotid arteries, and bilateral external jugular veins. The recurrent laryngeal nerve was anastomosed end-to-end. Then, a vascularized allograft was embeded in the cervical subcutaneous tissue of the recipient, and cyclosporine administered every day.
  
  
  RESULTS
  The allografts in groups 3, 4, and 5 survived up to 1 month. Groups 1 and 2 showed necrosis and cervical infection.
  
  
  CONCLUSIONS
  Beagles accepted laryngeal allotransplantation by stages (laryngeal allograft fore-embed model). Allograft survival was secluded by glandular organ secretion. Immunosuppression must be continuously administered.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The Affiliated Hospital of Medical College Qingdao University, Shanghai, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Jiang
authors.forename: P
authors.initials: P
authors.lastname: Dong
authors.forename: N
authors.initials: N
authors.lastname: Li
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.forename: H
authors.initials: H
authors.lastname: Xu
mesh_terms: D000818:Animals; D016572:Cyclosporine / Q000008:administration & dosage; D004285:Dogs; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007830:Larynx / Q000637:transplantation*; D011182:Postoperative Care; D014184:Transplantation, Homologous
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine