title: Giant basal cell carcinoma with regional lymph node and distant lung metastasis.
abstract: The prevalence of metastatic basal cell carcinoma (MBCC) varies between 0.0028% and 0.55% of all cases. In total, more than 300 MBCC have been reported in the literature. We report the case of a 72 year old lady, who presented in September 2009 with a 10-year history of a progressively growing, giant, facial basal cell carcinoma (BCC). Clinical and imaging evaluations identified large local invasion with bone and meningeal involvement. Treatment consisted of an extensive surgery including left eye exenteration and meningeal resection followed by radiotherapy. A solitary lung metastasis was identified five months after the primary tumor resection. As the lesion remained solitary but had increased in size five months later, the patient finally accepted a surgical resection. A right upper-lobe pneumonectomy was performed and pathologic examination confirmed the metastasis as a MBCC.
authors.affiliation: Service de Dermatologie, Hôpital Cochin, Université Paris-Descartes, Paris, France.
authors.forename: Saud
authors.initials: S
authors.lastname: Aldhaban
authors.forename: Siham
authors.initials: S
authors.lastname: Marc
authors.forename: Majed
authors.initials: M
authors.lastname: Eshki
authors.forename: Angélique
authors.initials: A
authors.lastname: Girod
authors.forename: Hervé
authors.initials: H
authors.lastname: Boissonet
authors.forename: Alain
authors.initials: A
authors.lastname: Chapelier
authors.forename: Agnès
authors.initials: A
authors.lastname: Carlotti
authors.forename: Xavier
authors.initials: X
authors.lastname: Sastre-Garau
authors.forename: Alexandra
authors.initials: A
authors.lastname: Athanasiou
authors.forename: Leila
authors.initials: L
authors.lastname: Zemoura
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Bolle
authors.forename: Daniel
authors.initials: D
authors.lastname: Wallach
authors.forename: Marie-Françoise
authors.initials: MF
authors.lastname: Avril
mesh_terms: D000368:Aged; D002280:Basal Cell Carcinoma / Q000473:pathology / Q000556:secondary*; D018450:Disease Progression; D005260:Female; D005546:Forehead / Q000473:pathology; D005624:Frontal Bone / Q000473:pathology; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary*; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging; D009361:Neoplasm Invasiveness; D017233:Orbit Evisceration; D012878:Skin Neoplasms / Q000473:pathology*; D003074:Solitary Pulmonary Nodule / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary*; D014057:Tomography, X-Ray Computed