title: Molecular determinants that convert hormone sensitive lipase into gibberellin receptor.
abstract: Gibberellins (GAs) are tetracyclic, diterpenoid plant hormones, essential for many developmental processes in higher plants. Plants perceive GA through a nuclear-localized GA receptor, GA INSENSITIVE DWARF1 (GID1). From sequence similarity, it is suggested that GID1 evolved from a hormone-sensitive lipase (HSL), and recent x-ray crystallography of the GA-GID1 complex has given insights into how GID1 recognizes GA. Analyses of the GA signaling pathway in several plant species further suggest that the GID1-mediated GA signaling pathway emerged in the vascular plant lineage and since then regulation of GA recognition specificity seems to have been fine tuned to strictly regulate the on-off GA signal.
authors.affiliation: Bioscience and Biotechnology Center, Nagoya University, Furo-cho Chikusa-ku, Nagoya 464-8601, Japan.
authors.forename: Ko
authors.initials: K
authors.lastname: Hirano
authors.forename: Koichiro
authors.initials: K
authors.lastname: Aya
authors.forename: Makoto
authors.initials: M
authors.lastname: Matsuoka
authors.forename: Miyako
authors.initials: M
authors.lastname: Ueguchi-Tanaka
mesh_terms: D029681:Arabidopsis Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D019143:Evolution, Molecular; D044783:F-Box Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D017343:Genes, Plant / Q000502:physiology; D005875:Gibberellins / Q000378:metabolism*; D008954:Models, Biological; D008958:Models, Molecular; D011485:Protein Binding / Q000235:genetics; D054730:Protein Interaction Domains and Motifs / Q000235:genetics* / Q000502:physiology; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D002787:Sterol Esterase / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D013379:Substrate Specificity / Q000235:genetics
chemical_list: D029681:Arabidopsis Proteins; D044783:F-Box Proteins; C512225:GID1a protein, Arabidopsis; D005875:Gibberellins; D011956:Receptors, Cell Surface; D002787:Sterol Esterase