title: Low genetic diversity of Pneumocystis jirovecii among Cuban population based on two-locus mitochondrial typing.
abstract: Genotypes of two different loci of the Pneumocystis jirovecii mitochondrial gene were studied in specimens from a total of 75 Pneumocystis pneumonia patients in Spain, France and Cuba. A new genotype of the mitochondrial small subunit rRNA gene of P. jirovecii (160A/196T) was identified, which was revealed to be the most common in these three countries, especially in Cuba where its proportion reached 93.8%. Our data imply that the new genotype might be circulating worldwide and also suggests that the distribution of P. jirovecii genotypes could be narrower in islands such as Cuba.
authors.affiliation: Institute of Tropical Medicine Pedro Kourí, Havana, Cuba.
authors.forename: Yaxsier
authors.initials: Y
authors.lastname: de Armas
authors.forename: Vicente
authors.initials: V
authors.lastname: Friaza
authors.forename: Virginia
authors.initials: V
authors.lastname: Capó
authors.forename: Isabelle
authors.initials: I
authors.lastname: Durand-Joly
authors.forename: Anamays
authors.initials: A
authors.lastname: Govín
authors.forename: Carmen
authors.initials: C
authors.lastname: de la Horra
authors.forename: Eduardo
authors.initials: E
authors.lastname: Dei-Cas
authors.forename: Enrique J
authors.initials: EJ
authors.lastname: Calderón
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003462:Cuba / Q000453:epidemiology; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D005602:France / Q000453:epidemiology; D020459:Genes, rRNA; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D058889:Molecular Typing; D016533:Mycological Typing Techniques; D045363:Pneumocystis carinii / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D011020:Pneumonia, Pneumocystis / Q000453:epidemiology* / Q000382:microbiology*; D013030:Spain / Q000453:epidemiology; D055815:Young Adult
chemical_list: D004272:DNA, Mitochondrial