title: Impact of maternal diabetes mellitus on mortality and morbidity of preterm infants (24-33 weeks' gestation).
abstract: OBJECTIVE
  We hypothesized that maternal diabetes mellitus (DM) increases the risk for mortality, respiratory distress syndrome (RDS), and major complications of prematurity.
  
  
  METHODS
  Analysis of prospectively collected (1995-2007) Israel National Very Low Birth Weight Infant Database. Maternal DM was recorded as pregestational or gestational. Multivariable logistic regression analysis was used to assess the independent effect of maternal DM status on infant mortality, RDS, and other complications of prematurity.
  
  
  RESULTS
  Infants of mothers with pregestational (n = 120) and gestational (n = 825) DM were similar, and their data were pooled for analyses. Mothers with DM were more likely to have received a complete course of prenatal steroids than control mothers. Infants of diabetic mothers (IDM) had a slightly higher gestational age and birthweight than non-IDM's. Distribution of birthweight percentiles and the mean birthweight z scores were similar. Apgar scores were statistically higher in the IDM group. There were no significant differences between the 2 groups in terms of delivery room mortality, RDS, and other major complications of prematurity. Total mortality and bronchopulmonary dysplasia rates were significantly higher in the nondiabetic group. The adjusted odds ratios for mortality, RDS, bronchopulmonary dysplasia, intraventricular hemorrhage, periventricular leukomalacia, retinopathy of prematurity, necrotizing enterocolitis, and patent ductus arteriosus were not significantly increased in the IDM group.
  
  
  CONCLUSIONS
  With modern management and adequate prenatal care, IDM born very low birthweight do not seem to be at an excess risk of developing RDS or other major complications of prematurity compared with non-IDM.
authors.affiliation: Department of Neonatology, Laniado Hospital, Divrei Chaim St, Netanya 42150, Israel. yabental@laniado.org.il
authors.forename: Yoram
authors.initials: Y
authors.lastname: Bental
authors.forename: Brian
authors.initials: B
authors.lastname: Reichman
authors.forename: Yakov
authors.initials: Y
authors.lastname: Shiff
authors.forename: Meir
authors.initials: M
authors.lastname: Weisbrod
authors.forename: Valentina
authors.initials: V
authors.lastname: Boyko
authors.forename: Liat
authors.initials: L
authors.lastname: Lerner-Geva
authors.forename: Francis B
authors.initials: FB
authors.lastname: Mimouni
mesh_terms: D000328:Adult; D016640:Diabetes, Gestational; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000453:epidemiology* / Q000401:mortality; D019102:Infant, Very Low Birth Weight; D007557:Israel / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D011247:Pregnancy; D011254:Pregnancy in Diabetics; D011446:Prospective Studies; D012127:Respiratory Distress Syndrome, Newborn / Q000453:epidemiology / Q000401:mortality; D012307:Risk Factors