title: Nanoemulsions as self-emulsified drug delivery carriers for enhanced permeability of the poorly water-soluble selective β₁-adrenoreceptor blocker Talinolol.
abstract: To enhance the bioavailability of the poorly water-soluble drug talinolol, a self-nanoemulsifying drug delivery system (SNEDDS) comprising 5% (w/v) Brij-721 ethanolic solution (Smix), triacetin, and water, in the ratio of 40:20:40 (% w/w) was developed by constructing pseudo-ternary phase diagrams and evaluated for droplet size, polydispersity index, and surface morphology of nanoemulsions. The effect of nanodrug carriers on drug release and permeability was assessed using stripped porcine jejunum and everted rat gut sac method and compared with hydroalcoholic drug solution, oily solution, and conventional emulsion and suspension. The SNEDDS showed a significant (P < 0.001) increase in drug release, permeability, and in vivo bioavailability as compared to drug suspension. This may be attributed to increased solubility and enhanced permeability of the drug from nanosized emulsion.
  
  
  BACKGROUND
  In this study, a self-nanoemulsifying drug delivery system was utilized to enhance the bioavailability of the poorly water-soluble beta-blocker talinolol. Significant increase in drug release, permeability, and in vivo bioavailability were demonstrated as compared to standard drug suspension.
authors.affiliation: University Institute of Pharmaceutical Sciences, Panjab university, Chandigarh, India.
authors.forename: Damanjeet
authors.initials: D
authors.lastname: Ghai
authors.forename: Vivek Ranjan
authors.initials: VR
authors.lastname: Sinha
mesh_terms: D058671:Adrenergic beta-1 Receptor Antagonists / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001682:Biological Availability; D004337:Drug Carriers / Q000737:chemistry / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D004655:Emulsions / Q000737:chemistry / Q000494:pharmacology; D007422:Intestines / Q000187:drug effects; D008297:Male; D053758:Nanoparticles / Q000737:chemistry*; D009924:Organ Culture Techniques; D010539:Permeability / Q000187:drug effects; D011412:Propanolamines / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility; D013499:Surface Properties / Q000187:drug effects; D013552:Swine
chemical_list: D058671:Adrenergic beta-1 Receptor Antagonists; D004337:Drug Carriers; D004655:Emulsions; D011412:Propanolamines; C011550:talinolol