title: Visualization of numerical centrosomal abnormalities by immunofluorescent staining.
abstract: The presence of multiple centrosomes in tumor cells is associated with the formation of multipolar mitotic spindles and results in aneuploidy of both daughter cells. Centrosome amplification is a feature of all cancer cells. We have previously described centrosome amplification in abnormal B cells. Further studies of centrosome amplification in different stages of B lineage development could provide important information about multiple myeloma pathogenesis.
authors.affiliation: Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
authors.forename: F
authors.initials: F
authors.lastname: Kryukov
authors.forename: E
authors.initials: E
authors.lastname: Dementyeva
authors.forename: P
authors.initials: P
authors.lastname: Kuglík
authors.forename: R
authors.initials: R
authors.lastname: Hájek
mesh_terms: D001402:B-Lymphocytes / Q000648:ultrastructure*; D018385:Centrosome / Q000648:ultrastructure*; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique / Q000379:methods*; D006801:Humans; D009101:Multiple Myeloma / Q000648:ultrastructure*; D010950:Plasma Cells / Q000648:ultrastructure*