title: [Pentraxins - their importance in pathogenesis of systemic lupus erythematosus].
abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease, whose main pathomechanism is attributed to the disturbed apoptotic process and dysfunction of the immune cells, leading to the accumulation of undegraded cellular matrix. This paper presents molecules such as complement components, pentraxins, and collectins, which are involved in the opsonization and removal of cellular material, and shows how deficiencies in these processes may contribute to SLE development and progression. Many reports indicate the specific role of the pentraxins (C-reactive protein, serum amyloid P, pentraxin 3), which, due to enhancing the phagocytosis of damaged cells and inducing the classical pathway of complement activation, participate in masking antigens from the immune system. The influence of CRP on inhibition of development and progression of kidney disease and decreasing the immune activity markers was demonstrated on the basis of research in experimental, mouse models of SLE. The decreased pentraxin response described in systemic lupus erythematosus patients, despite the presence of high levels of interleukin-6 and other markers of disease activity, is still unclear. Anti-mCRP antibodies bind CRP to form immune complexes, which are deposited in glomeruli and may initiate or exacerbate inflammation. In the literature, the correlation between raised levels of anti-CRP antibodies and clinical and immunological activity of lupus nephritis was proved. It shows their importance as a factor determining the severity of the disease and response to treatment. Novel studies suggest that the low CRP response in SLE is due to interferon-α inhibition of gene expression and CRP synthesis. This suggests that therapeutic targets in systemic lupus erythematosus should also be based on inhibiting the synthesis of interferon-α .
authors.affiliation: Klinika Nefrologii i Medycyny Transplantacyjnej Akademii Medycznej we Wrocławiu. kasia.jakuszko@wp.pl
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Jakuszko
authors.forename: Magdalena
authors.initials: M
authors.lastname: Krajewska
authors.forename: Wacław
authors.initials: W
authors.lastname: Weyde
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Grzegorczyk
authors.forename: Marian
authors.initials: M
authors.lastname: Klinger
mesh_terms: D000818:Animals; D002097:C-Reactive Protein / Q000276:immunology*; D018450:Disease Progression; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D051379:Mice; D000683:Serum Amyloid P-Component / Q000276:immunology; D000099153:Pentraxins
chemical_list: D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins