title: Molecular epidemiology of Clostridium difficile strains in children compared with that of strains circulating in adults with Clostridium difficile-associated infection.
abstract: Molecular analysis of Clostridium difficile (28 isolates) from children (n = 128) in Oxfordshire, United Kingdom, identified eight toxigenic genotypes. Six of these were isolated from 27% of concurrent adult C. difficile-associated infections studied (n = 83). No children carried hypervirulent PCR ribotype 027. Children could participate in the transmission of some adult disease-causing genotypes.
authors.affiliation: Nuffield Department of Clinical Medicine, Oxford University, John Radcliffe Hospital, Oxford OX3 9DU, UK. nicole.stoesser@ndm.ox.ac.uk
authors.forename: Nicole
authors.initials: N
authors.lastname: Stoesser
authors.forename: Derrick W
authors.initials: DW
authors.lastname: Crook
authors.forename: Rowena
authors.initials: R
authors.lastname: Fung
authors.forename: David
authors.initials: D
authors.lastname: Griffiths
authors.forename: Rosalind M
authors.initials: RM
authors.lastname: Harding
authors.forename: Melina
authors.initials: M
authors.lastname: Kachrimanidou
authors.forename: Satish
authors.initials: S
authors.lastname: Keshav
authors.forename: Tim E
authors.initials: TE
authors.lastname: Peto
authors.forename: Alison
authors.initials: A
authors.lastname: Vaughan
authors.forename: A Sarah
authors.initials: AS
authors.lastname: Walker
authors.forename: Kate E
authors.initials: KE
authors.lastname: Dingle
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002675:Child, Preschool; D016360:Clostridioides difficile / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D003015:Clostridium Infections / Q000453:epidemiology* / Q000382:microbiology*; D004269:DNA, Bacterial / Q000235:genetics; D005838:Genotype; D006801:Humans; D007223:Infant; D008875:Middle Aged; D017720:Molecular Epidemiology; D021521:Ribotyping; D006113:United Kingdom / Q000453:epidemiology; D055815:Young Adult
chemical_list: D004269:DNA, Bacterial