title: Immunoexpression of TNF-α and TGF-β in central and peripheral giant cell lesions of the jaws.
abstract: BACKGROUND
  Peripheral giant cell lesion (PGCL) is a reactive process associated with a local irritating factor that shows low recurrence after treatment, especially if the irritating factor is eliminated. On the other hand, central giant cell lesion (CGCL) presents a variable clinical behavior ranging from slow and asymptomatic growth without recurrence to rapid, painful and recurrent growth. Our aim was to compare the immunoexpression of tumor necrosis factor-alpha (TNF-α) and transforming growth factor-beta (TGF-β) in CGCL and PGCL.
  
  
  METHODS
  Twenty CGCL and 20 PGCL were selected for analysis of the immunoexpression of TNF-α and TGF-β in multinucleated giant cells (MGC) and mononucleated cells (MC).
  
  
  RESULTS
  The PGCL showed lightly higher expression of TNF-α than CGCL. In comparison with PGCL, the CGCL showed higher expression of TGF-β in MC and MGC (P < 0.05) and in total cells (P < 0.05). Significant positive correlation was found between expressions of TGF-β and TNF-α in CGCL (P < 0.05).
  
  
  CONCLUSIONS
  Our results suggest that, in CGCL, coordinated interactions between TGF-β and TNF-α may be important for osteoclastogenesis and bone resorption. PGCL occasionally cause bone resorption but to a lower extent, a fact that might be explained by the lower expression of TGF-β in these lesions.
authors.affiliation: Postgraduate Program, Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Felipe Rodrigues
authors.initials: FR
authors.lastname: de Matos
authors.forename: Maiara
authors.initials: M
authors.lastname: de Moraes
authors.forename: Cassiano Francisco Weege
authors.initials: CF
authors.lastname: Nonaka
authors.forename: Lélia Batista
authors.initials: LB
authors.lastname: de Souza
authors.forename: Roseana
authors.initials: R
authors.lastname: de Almeida Freitas
mesh_terms: D001862:Bone Resorption / Q000473:pathology; D015726:Giant Cells / Q000473:pathology; D006101:Granuloma, Giant Cell / Q000473:pathology*; D006801:Humans; D007571:Jaw Diseases / Q000473:pathology*; D007963:Leukocytes, Mononuclear / Q000473:pathology; D010010:Osteoclasts / Q000473:pathology; D016212:Transforming Growth Factor beta / Q000032:analysis*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
chemical_list: D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha