title: Umbilical cord blood concentration of soluble scavenger receptor for hemoglobin, but not pentraxin 3, is of value for the early postpartum identification of the presence of histological chorioamnionitis.
abstract: OBJECTIVE
  To determine whether umbilical cord blood concentrations of soluble scavenger receptor for hemoglobin (sCD163) and pentraxin 3 (PTX3) are of value in the early postpartum diagnosis of histological chorioamnionitis in preterm prelabor rupture of membranes (PPROM).
  
  
  METHODS
  Eighty-three women with pregnancies complicated by PPROM between 24 and 36 weeks of gestation with (n = 38) and without (n = 45) the presence of histological chorioamnionitis were included in the study. We compared umbilical cord blood sCD163 and PTX3 levels in preterm neonates from PPROM pregnancies with versus without the presence of histological chorioamnionitis using nonparametric test (Mann-Whitney U test).
  
  
  RESULTS
  The presence of histological chorioamnionitis was associated with a higher median umbilical cord blood sCD163, but not PTX3 concentration, to compare with the absence of histological chorioamnionitis [sCD163: median 1466 ng/mL, interquartile range (IQR) 1187-1828 vs. 1168 ng/mL, IQR 887-1595; p = 0.01; PTX3: median 3.96 ng/mL, IQR 2.24-6.77 vs. 2.95 ng/mL, IQR 1.74-6.93; p = 0.49].
  
  
  CONCLUSIONS
  HCA is associated with an increase of umbilical cord blood sCD163, but not PTX3 concentration. Umbilical cord blood sCD163 seems to be a postpartum marker of the presence of histological chorioamnionitis.
authors.affiliation: Department of Obstetrics and Gynecology, Charles University, Medical School and University Hradec Kralove, Czech Republic. kacermar@fnhk.cz
authors.forename: Marian
authors.initials: M
authors.lastname: Kacerovsky
authors.forename: Marcela
authors.initials: M
authors.lastname: Drahosova
authors.forename: Helena
authors.initials: H
authors.lastname: Hornychova
authors.forename: Vojtech
authors.initials: V
authors.lastname: Tambor
authors.forename: Eva
authors.initials: E
authors.lastname: Flidrova
authors.forename: Ivana
authors.initials: I
authors.lastname: Musilova
authors.forename: Jindrich
authors.initials: J
authors.lastname: Tosner
authors.forename: Ctirad
authors.initials: C
authors.lastname: Andrys
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000097:blood*; D015214:Antigens, Differentiation, Myelomonocytic / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D002821:Chorioamnionitis / Q000097:blood* / Q000175:diagnosis; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D049590:Postpartum Period; D011247:Pregnancy; D011446:Prospective Studies; D011956:Receptors, Cell Surface / Q000097:blood*; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D000098902:CD163 Antigen; D000099153:Pentraxins
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D015415:Biomarkers; D002097:C-Reactive Protein; D011956:Receptors, Cell Surface; D000683:Serum Amyloid P-Component; D000098902:CD163 Antigen; D000099153:Pentraxins