title: EUCAST technical note on anidulafungin.
abstract: The European Committee on Antimicrobial Susceptibility Testing-Subcommittee on Antifungal Susceptibility Testing has determined breakpoints for anidulafungin for Candida spp. This Technical Note is based on the EUCAST anidulafungin rationale document (available at: http://www.eucast.org). Species-specific breakpoints for C. albicans are S ≤0.03 mg/L and R >0.03 mg/L and for C. glabrata, C. tropicalis and C. krusei S ≤0.06 mg/L and R >0.06 mg/L. C. parapsilosis was not regarded a good target for anidulafungin. There are insufficient data to set breakpoints for other species. The breakpoints are based upon pharmacokinetic data, epidemiological cut-off values and clinical experience. Breakpoints will be reviewed regularly.
authors.affiliation: Unit of Mycology, Department of Microbiological Surveillance and Research, Statens Serum Institute, Copenhagen, Denmark. maiken@arendrup.dk
authors.forename: M C
authors.initials: MC
authors.lastname: Arendrup
authors.forename: J-L
authors.initials: JL
authors.lastname: Rodriguez-Tudela
authors.forename: C
authors.initials: C
authors.lastname: Lass-Flörl
authors.forename: M
authors.initials: M
authors.lastname: Cuenca-Estrella
authors.forename: J P
authors.initials: JP
authors.lastname: Donnelly
authors.forename: W
authors.initials: W
authors.lastname: Hope
mesh_terms: D000077612:Anidulafungin; D000935:Antifungal Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D054714:Echinocandins / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D000077612:Anidulafungin