title: Allogeneic stem cell transplantation in first complete remission.
abstract: OBJECTIVE
  The optimal postremission therapy of acute myeloid leukemia (AML) in first complete remission (CR1) is uncertain. This review summarizes the recent developments in the clinical research and therapeutic applications defining the role of allogeneic hematopoietic stem cell transplantation (allo-HCT) in CR1.
  
  
  RESULTS
  Molecular markers in combinations with cytogenetics have improved the risk stratification and informed decision-making in patients with AML in CR1. In parallel, several important advances in the transplant field, such as better supportive care, improved transplant technology, increased availability of alternative donors, and reduced-intensity conditioning, have improved the safety as well as access of allo-HCT for a larger number of patients.
  
  
  CONCLUSIONS
  The progress in risk stratification and in transplant technology dictate that early donor identification search should be initiated for all eligible AML patients in CR1.
authors.affiliation: Blood and Marrow Transplantation Program, University of Minnesota, Minneapolis, Minnesota, USA. oranx002@umn.edu
authors.forename: Betul
authors.initials: B
authors.lastname: Oran
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Weisdorf
mesh_terms: D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000235:genetics / Q000628:therapy*; D012074:Remission Induction; D018570:Risk Assessment