title: Polyphenols and human health: a prospectus.
abstract: The lay press often heralds polyphenols as panacea for all sorts of diseases. The rationale is that their antioxidant activity would prevent free radical damage to macromolecules. However, basic and clinical science is showing that the reality is much more complex than this and that several issues, notably content in foodstuff, bioavailability, or in vivo antioxidant activity are yet to be resolved. We summarize the recent findings concerning the effects of polyphenols on human health, analyze the current limitations at pitfalls, and propose future directions for research.
authors.affiliation: IMDEA-Food, Madrid, Spain. francesco.visioli@imdea.org
authors.forename: Francesco
authors.initials: F
authors.lastname: Visioli
authors.forename: Catalina Alarcón
authors.initials: CA
authors.lastname: De La Lastra
authors.forename: Cristina
authors.initials: C
authors.lastname: Andres-Lacueva
authors.forename: Michael
authors.initials: M
authors.lastname: Aviram
authors.forename: Conceição
authors.initials: C
authors.lastname: Calhau
authors.forename: Alfredo
authors.initials: A
authors.lastname: Cassano
authors.forename: Massimo
authors.initials: M
authors.lastname: D'Archivio
authors.forename: Ana
authors.initials: A
authors.lastname: Faria
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Favé
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Fogliano
authors.forename: Rafael
authors.initials: R
authors.lastname: Llorach
authors.forename: Paola
authors.initials: P
authors.lastname: Vitaglione
authors.forename: Mario
authors.initials: M
authors.lastname: Zoratti
authors.forename: Marvin
authors.initials: M
authors.lastname: Edeas
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000493:pharmacokinetics / Q000494:pharmacology*; D001682:Biological Availability; D015415:Biomarkers / Q000032:analysis; D003474:Curcumin / Q000737:chemistry; D004032:Diet; D005504:Food Analysis; D005609:Free Radicals; D006801:Humans; D029561:Lythraceae / Q000737:chemistry; D055432:Metabolomics / Q000379:methods; D008928:Mitochondria / Q000378:metabolism; D059808:Polyphenols / Q000493:pharmacokinetics / Q000494:pharmacology*; D014920:Wine / Q000032:analysis
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D005609:Free Radicals; D059808:Polyphenols; D003474:Curcumin