title: Quantitative color mapping of the arterial enhancement fraction in patients with diffuse liver disease.
abstract: OBJECTIVE
  The purpose of this study was to determine whether color mapping of the arterial enhancement fraction of the liver with multiphasic liver CT can depict the hemodynamic changes associated with diffuse liver disease.
  
  
  METHODS
  A total of 142 patients (59 men, 83 women; mean age, 50 years) with diffuse liver disease and 25 patients acting as controls (11 men, 14 women; mean age, 54 years) were classified into three groups: controls (n = 25), patients with acute liver injury (no underlying chronic liver disease [n = 25], acute exacerbation of chronic liver disease [n = 17]), and patients with chronic hepatic injury (hepatitis [n = 25]; cirrhosis [n = 75], 25 each with Child-Pugh A, B, and C disease). The quantitative arterial enhancement fraction color map of the liver was generated from routine multiphasic CT images with prototype software. The mean arterial enhancement fractions of each group were compared by analysis of variance. The correlation between arterial enhancement fraction and Child-Pugh grade was evaluated with Spearman correlation. The area under the receiver operating characteristic curve for arterial enhancement fraction in the detection of acute liver injury and noncompensated chronic liver disease was calculated.
  
  
  RESULTS
  The mean arterial enhancement fractions of the liver in each group were significantly different (p < 0.0001, analysis of variance): control, 28.5%; acute liver injury without underlying chronic liver disease, 51.1%; acute exacerbation of chronic liver disease, 42.0%; chronic hepatitis, 25.4%; Child-Pugh A disease, 23.7%; Child-Pugh B disease, 32.2%; Child-Pugh C disease, 43.4%. Arterial enhancement fraction correlated with Child-Pugh grade (Spearman ρ = 0.553, p < 0.0001). The areas under the curve of arterial enhancement fraction in the detection of acute liver injury and noncompensated chronic liver disease were 0.96 and 0.78.
  
  
  CONCLUSIONS
  With color mapping of the arterial enhancement fraction derived from multiphasic liver CT scans, it is possible to visualize the hemodynamic changes associated with the severity of cirrhosis and acute liver injury.
authors.affiliation: Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, 28 Yeongon-dong, 101 Daehangno, Jongno-gu, Seoul 110-744, Korea.
authors.forename: Sung Eun
authors.initials: SE
authors.lastname: Kang
authors.forename: Jeong Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Ernst
authors.initials: E
authors.lastname: Klotz
authors.forename: Kyung Won
authors.initials: KW
authors.lastname: Kim
authors.forename: Jung Hoon
authors.initials: JH
authors.lastname: Kim
authors.forename: Joon Koo
authors.initials: JK
authors.lastname: Han
authors.forename: Byung Ihn
authors.initials: BI
authors.lastname: Choi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D019540:Area Under Curve; D016022:Case-Control Studies; D003116:Color; D003287:Contrast Media; D005260:Female; D006801:Humans; D007472:Iohexol / Q000031:analogs & derivatives; D008102:Liver Circulation; D008107:Liver Diseases / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D007472:Iohexol; C038192:iopromide