title: Dynamic change of tetraspanin CD151 membrane protein expression in colorectal cancer patients.
abstract: OBJECTIVE
  To measure the CD151 expression in colorectal cancer (CRC).
  
  
  METHODS
  CD151 expression was assessed in 179 CRC patients and 39 patients with hepatic liver metastasis.
  
  
  RESULTS
  High CD151 expression was observed in 48% of patients with early-stage CRC versus only 33% of patients with metastatic colon cancer. A higher level of tumor invasion status correlated with a decrease in CD151 expression. Metastatic stage and advanced tumor stage correlated with a decreased CD151 expression. Twenty-seven out of the 39-paired samples had high CD151 expression in liver metastasis sites.
  
  
  CONCLUSIONS
  CD151 expression is decreased in patients with metastatic CRC.
authors.affiliation: Department of Surgery, National Cheng-Kung University Hospital, Tainan, Taiwan.
authors.forename: Peng-Chan
authors.initials: PC
authors.lastname: Lin
authors.forename: Shao-Chieh
authors.initials: SC
authors.lastname: Lin
authors.forename: Chung-Ta
authors.initials: CT
authors.lastname: Lee
authors.forename: Yih-Jyh
authors.initials: YJ
authors.lastname: Lin
authors.forename: Jenq-Chang
authors.initials: JC
authors.lastname: Lee
mesh_terms: D000236:Adenoma / Q000737:chemistry; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000032:analysis*; D015179:Colorectal Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D060185:Tetraspanin 24
chemical_list: D015703:Antigens, CD; C554715:CD151 protein, human; D060185:Tetraspanin 24