title: Developmental trajectories of adaptive behaviors from early childhood to adolescence in a cohort of 152 children with autism spectrum disorders.
abstract: This study examines change in 152 children over an almost 10-year period (T1: 4.9 (± 1.3) years; T2: 8.1 (± 1.3) years; T3: 15(± 1.6) years) using a group-based, semi-parametric method in order to identify distinct developmental trajectories. Important deficits remain at adolescence in the adaptive abilities of children with Autism spectrum disorders, but changes in adaptive skills show two distinct growth rates. The univariate analysis reveals that low growth trajectories for both social and communication outcome are associated with the following characteristics at age 5: low cognitive and language skills, presence of epilepsy, and severity of autism. The multivariate analysis confirms that risk factors at age 5, were low language and severity of autism for both social and communication outcomes 10 years later, and that hours of early intervention was protective factor for communication.
authors.affiliation: Autism Resources Center, Child and Adolescent Psychiatry Department, CHU Montpellier and Laboratory Epsylon, University of Montpellier, 39 Avenue Charles Flahaut, 34295 Montpellier cedex 05, France.
authors.forename: Amaria
authors.initials: A
authors.lastname: Baghdadli
authors.forename: Brigitte
authors.initials: B
authors.lastname: Assouline
authors.forename: Sandrine
authors.initials: S
authors.lastname: Sonié
authors.forename: Eric
authors.initials: E
authors.lastname: Pernon
authors.forename: Céline
authors.initials: C
authors.lastname: Darrou
authors.forename: Cécile
authors.initials: C
authors.lastname: Michelon
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Picot
authors.forename: Charles
authors.initials: C
authors.lastname: Aussilloux
authors.forename: René
authors.initials: R
authors.lastname: Pry
mesh_terms: D000223:Adaptation, Psychological; D000293:Adolescent; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology*; D002675:Child, Preschool; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D015331:Cohort Studies; D003142:Communication; D015897:Comorbidity; D004827:Epilepsy / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006306:Health Surveys; D006801:Humans; D007805:Language Development Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D008297:Male; D015999:Multivariate Analysis; D009769:Object Attachment; D011379:Prognosis; D012917:Social Adjustment; D014481:United States