title: Fournier's gangrene in a patient receiving treatment for idiopathic thrombocytopenic purpura.
abstract: We report the case of a 68-year-old man who was diagnosed with Fournier's gangrene (FG), which developed during immunosuppresive treatment for idiopathic thrombocytopenic purpura (ITP). The patient was administered steroids for ITP but on the 36th day, he developed FG and septic shock. We initiated antibiotic treatment and drained a periproctal abscess immediately. On day 53, extensive drainage to progressive FG and a splenectomy was performed, following which both FG and thrombocytopenia improved. This is the first case of FG has developing in a ITP patient. It appears that high-dose immunoglobulin therapy and splenectomy should be considered earlier especially for a patient complicated with FG.
authors.affiliation: Department of Hematology, Yamagata Prefectural Central Hospital, Japan.
authors.forename: Junichiro
authors.initials: J
authors.lastname: Yuda
authors.forename: Riko
authors.initials: R
authors.lastname: Honma
authors.forename: Tomoyasu
authors.initials: T
authors.lastname: Yahagi
authors.forename: Eijiro
authors.initials: E
authors.lastname: Omoto
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D018934:Fournier Gangrene / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D007710:Klebsiella Infections / Q000150:complications; D007711:Klebsiella pneumoniae / Q000302:isolation & purification; D008297:Male; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy*; D013156:Splenectomy; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents