title: Recovery of symptomatic extravasation of liposomal doxorubicin after dexrazoxane treatment.
abstract: A patient with metastatic ovarian cancer was treated with liposomal doxorubicin and carboplatin. She had an extravasation during liposomal doxorubicin infusion. Initially, she was treated conservatively with cold compresses and topical treatment. However, because of worsening of symptoms, she received dexrazoxane once daily for 3 days after which complete recovery occurred. This is the first casereport on symptomatic extravasation of liposomal doxorubicin treated with dexrazoxane.
authors.affiliation: Department of Medical Oncology, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands. f.devos@onco.umcn.nl
authors.forename: Filip Yves De
authors.initials: FY
authors.lastname: Vos
authors.forename: Willem Joost
authors.initials: WJ
authors.lastname: Lesterhuis
authors.forename: Roger Johannes
authors.initials: RJ
authors.lastname: Brüggemann
authors.forename: Winette Tita van der
authors.initials: WT
authors.lastname: Graaf
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D011929:Razoxane / Q000627:therapeutic use*
chemical_list: D011929:Razoxane; D004317:Doxorubicin; D016190:Carboplatin