title: [Target-specific screening of antivirulence preparations for chronic infection therapy].
abstract: Global spread of clinically significant strains resistant to antibiotics necessitated the development of new approaches to generation of antibacterial preparations. Selection of virulence factors as targets for new preparations is an alternative approach to therapy of infections caused by resistant strains and chronic infectious diseases. Contemporary state of research aimed at target selection among virulence factors of pathogenic for humans bacteria that cause chronic infections, and screening of specific inhibitors of these targets are examined. Analysis of limited data of therapeutic activity of selected preparations, i.e. experimental confirmation of the proposed concept, is provided.
authors.forename: N A
authors.initials: NA
authors.lastname: Zigangirova
authors.forename: A L
authors.initials: AL
authors.lastname: Gintsburg
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects* / Q000472:pathogenicity; D001424:Bacterial Infections / Q000188:drug therapy*; D018441:Biofilms / Q000187:drug effects / Q000254:growth & development; D002448:Cell Adhesion; D002908:Chronic Disease; D055808:Drug Discovery; D006801:Humans; D037521:Virulence Factors / Q000037:antagonists & inhibitors*
chemical_list: D000900:Anti-Bacterial Agents; D037521:Virulence Factors