title: Logistic Organ Dysfunction Score (LODS): a reliable postoperative risk management score also in cardiac surgical patients?
abstract: BACKGROUND
  The original Logistic Organ Dysfunction Sore (LODS) excluded cardiac surgery patients from its target population, and the suitability of this score in cardiac surgery patients has never been tested. We evaluated the accuracy of the LODS and the usefulness of its daily measurement in cardiac surgery patients. The LODS is not a true logistic scoring system, since it does not use β-coefficients.
  
  
  METHODS
  This prospective study included all consecutive adult patients who were admitted to the intensive care unit (ICU) after cardiac surgery between January 2007 and December 2008. The LODS was calculated daily from the first until the seventh postoperative day. Performance was assessed with Hosmer-Lemeshow (HL) goodness-of-fit test (calibration) and receiver operating characteristic (ROC) curves (discrimination) from ICU admission day until day 7. The outcome measure was ICU mortality.
  
  
  RESULTS
  A total of 2801 patients (29.6% female) with a mean age of 66.4 ± 10.7 years were included. The ICU mortality rate was 5.2% (n = 147). The mean stay on the ICU was 4.3 ± 6.8 days. Calibration of the LODS was good with no significant difference between expected and observed mortality rates on any day (p ≥ 0.05). The initial LODS had an area under the ROC curve (AUC) of 0.81. The AUC was best on ICU day 3 with a value of 0.93, and declined to 0.85 on ICU day 7.
  
  
  CONCLUSIONS
  Although the LODS has not previously been validated for cardiac surgery patients it showed reasonable accuracy in prediction of ICU mortality in patients after cardiac surgery.
authors.affiliation: Department of Cardiothoracic Surgery, Friedrich-Schiller-University of Jena, Erlanger Allee 101, 07747 Jena, Germany.
authors.forename: Matthias B
authors.initials: MB
authors.lastname: Heldwein
authors.forename: Akmal M A
authors.initials: AM
authors.lastname: Badreldin
authors.forename: Fabian
authors.initials: F
authors.lastname: Doerr
authors.forename: Thomas
authors.initials: T
authors.lastname: Lehmann
authors.forename: Ole
authors.initials: O
authors.lastname: Bayer
authors.forename: Torsten
authors.initials: T
authors.lastname: Doenst
authors.forename: Khosro
authors.initials: K
authors.lastname: Hekmat
mesh_terms: D000368:Aged; D019540:Area Under Curve; D006348:Cardiac Surgical Procedures; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D009102:Multiple Organ Failure / Q000401:mortality*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D012308:Risk Management / Q000379:methods*; D012720:Severity of Illness Index