title: High prevalence of human papillomavirus infection in Eastern European and West African women immigrants in South Italy.
abstract: Surveillance of human papillomavirus (HPV) prevalence and genotype distribution in migrant women from middle and low-income countries to developed countries is limited. The aim of this study was to analyze the spectrum of HPV genotypes and prevalence of cervical abnormalities in women emigrated mainly from Eastern Europe and West Africa and living in Southern Italy. The study included 233 migrant and 98 Italian-born women who self-referred to two gynecological outpatient clinics in the Campania region. Cervical specimens were subjected to cytological examination and viral testing by broad spectrum PCR. The prevalence rates of HPV infection were 57.9% and 94.1% among migrant and 19.4% and 88.5% among Italian women with normal and abnormal cytology respectively. HPV infection was detected in 56.1% of Southern and Eastern European, 62.5% of Central and South American, 55.5% of West African, and 73.3% of Southern Asian women with normal cervix. Among the 140 HPV-positive migrants, a total of 28 mucosal HPV genotypes were identified of which 11 types (HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, and 58), epidemiological classified as carcinogenic to humans (group 1), accounted for 73.4% of all infections. As expected, HPV16 was the most common viral type in all groups with frequency rates ranging from 12.5% in African to 30.1% in Eastern and Southern European women. In conclusion, the estimated prevalence of HPV infection among migrant women is very high, probably reflecting either lifestyle or high incidence of HPV in their country of origin. The implementation of vaccination strategies and cervical cancer surveillance are critical for women in this risk group.
authors.affiliation: Molecular Biology and Viral Oncology and AIDS Reference Centre, National Cancer Institute, "Fond. Pascale", Naples, Italy.
authors.forename: Maria Lina
authors.initials: ML
authors.lastname: Tornesello
authors.forename: Rosaria
authors.initials: R
authors.lastname: Cassese
authors.forename: Nicoletta
authors.initials: N
authors.lastname: De Rosa
authors.forename: Luigi
authors.initials: L
authors.lastname: Buonaguro
authors.forename: Anna
authors.initials: A
authors.lastname: Masucci
authors.forename: Gabriele
authors.initials: G
authors.lastname: Vallefuoco
authors.forename: Stefano
authors.initials: S
authors.lastname: Palmieri
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Schiavone
authors.forename: Roberto
authors.initials: R
authors.lastname: Piccoli
authors.forename: Franco M
authors.initials: FM
authors.lastname: Buonaguro
mesh_terms: D000328:Adult; D000349:Africa / Q000208:ethnology; D000368:Aged; D002584:Cervix Uteri / Q000166:cytology / Q000821:virology; D016009:Chi-Square Distribution; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D005061:Europe, Eastern / Q000208:ethnology; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology; D016133:Polymerase Chain Reaction; D015995:Prevalence; D002577:Uterine Cervical Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000821:virology; D014626:Vaginal Smears; D055815:Young Adult
chemical_list: D004279:DNA, Viral