title: A Pd-mediated new strategy to functionalized 2-aminochromenes: their in vitro evaluation as potential anti tuberculosis agents.
abstract: A multi component based synthesis involving palladium catalyzed C-C bond forming reaction has been developed as a new strategy to access systematically modified functionalized 2-aminochromenes. This MCR involves the use of bromobenzaldehyde as a key component and is highlighted by generating a new compound library. Many of these compounds showed Mycobacterium tuberculosis H37Rv chorismate mutase inhibiting properties in vitro representing the lead example of chorismate mutase inhibition by heteroarene based compounds.
authors.affiliation: Dr. Reddy's Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500 049, India.
authors.forename: T
authors.initials: T
authors.lastname: Ram Reddy
authors.forename: L
authors.initials: L
authors.lastname: Srinivasula Reddy
authors.forename: G
authors.initials: G
authors.lastname: Rajeshwar Reddy
authors.forename: Venkata Subbaiah
authors.initials: VS
authors.lastname: Nuthalapati
authors.forename: Y
authors.initials: Y
authors.lastname: Lingappa
authors.forename: Sandhya
authors.initials: S
authors.lastname: Sandra
authors.forename: Ravikumar
authors.initials: R
authors.lastname: Kapavarapu
authors.forename: Parimal
authors.initials: P
authors.lastname: Misra
authors.forename: Manojit
authors.initials: M
authors.lastname: Pal
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology*; D001578:Benzopyrans / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D066298:In Vitro Techniques; D020128:Inhibitory Concentration 50; D008958:Models, Molecular; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010165:Palladium / Q000737:chemistry*
chemical_list: D000995:Antitubercular Agents; D001578:Benzopyrans; D010165:Palladium