title: Brain tumors in adults with medically intractable epilepsy.
abstract: Much of the literature on tumors arising in the setting of chronic epilepsy focuses on children. This study reviewed 1 institution's 141-patient experience with tumors in adults arising in this clinical setting. The majority of tumors (71.6%) arose in the temporal lobe. The most common tumor types encountered included ganglioglioma (n = 38), low-grade fibrillary astrocytoma (n = 24), and low-grade oligodendroglioma (n = 22). Coexistent focal cortical dysplasia (type IA) was identified in 15 cases (10.6%). The largest group of tumors in adults were World Health Organization (WHO) grade II neoplasms compared with WHO grade I tumors in children. Gangliogliomas are the most commonly encountered neoplasms. Coexistent focal cortical dysplasia may be observed in a significant minority of tumors, suggesting a possible developmental origin for some of these neoplasms.
authors.affiliation: Departmentof Anatomic Pathology, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH 44195, USA.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Prayson
mesh_terms: D000328:Adult; D001254:Astrocytoma / Q000150:complications* / Q000473:pathology; D001932:Brain Neoplasms / Q000150:complications* / Q000473:pathology; D004827:Epilepsy / Q000209:etiology* / Q000473:pathology; D005260:Female; D018303:Ganglioglioma / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D054220:Malformations of Cortical Development / Q000150:complications / Q000473:pathology; D008875:Middle Aged; D009837:Oligodendroglioma / Q000150:complications* / Q000473:pathology; D012189:Retrospective Studies; D055815:Young Adult