title: Regenerated luminal epithelial cells are derived from preexisting luminal epithelial cells in adult mouse prostate.
abstract: Determining the source of regenerated luminal epithelial cells in the adult prostate during androgen deprivation and replacement will provide insights into the origin of prostate cancer cells and their fate during androgen deprivation therapy. Prostate stem cells in the epithelial layer have been suggested to give rise to luminal epithelium. However, the extent of stem cell participation to prostate regrowth is not clear. In this report, using prostate-specific antigen-CreER(T2)-based genetic lineage marking/tracing in mice, preexisting luminal epithelial cells were shown to be a source of regenerated luminal epithelial cells in the adult prostate. Prostatic luminal epithelial cells could survive androgen deprivation and were capable of proliferating upon androgen replacement. Prostate cancer cells, typically exhibiting a luminal epithelial phenotype, may retain this intrinsic capability to survive and regenerate in response to changes in androgen signaling, providing part of the mechanism for the ultimate failure of androgen deprivation therapy in prostate cancer.
authors.affiliation: Department of Urology, University of Pittsburgh School of Medicine, Pennsylvania 15232, USA. liuj173@gmail.com
authors.forename: June
authors.initials: J
authors.lastname: Liu
authors.forename: Laura E
authors.initials: LE
authors.lastname: Pascal
authors.forename: Sudhir
authors.initials: S
authors.lastname: Isharwal
authors.forename: Daniel
authors.initials: D
authors.lastname: Metzger
authors.forename: Raquel
authors.initials: R
authors.lastname: Ramos Garcia
authors.forename: Jan
authors.initials: J
authors.lastname: Pilch
authors.forename: Susan
authors.initials: S
authors.lastname: Kasper
authors.forename: Karin
authors.initials: K
authors.lastname: Williams
authors.forename: Per H
authors.initials: PH
authors.lastname: Basse
authors.forename: Joel B
authors.initials: JB
authors.lastname: Nelson
authors.forename: Pierre
authors.initials: P
authors.lastname: Chambon
authors.forename: Zhou
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D004847:Epithelial Cells / Q000166:cytology* / Q000378:metabolism; D008297:Male; D051379:Mice; D018613:Microscopy, Confocal; D008856:Microscopy, Fluorescence; D011467:Prostate / Q000166:cytology* / Q000378:metabolism; D017430:Prostate-Specific Antigen / Q000235:genetics / Q000378:metabolism; D013739:Testosterone / Q000494:pharmacology
chemical_list: D013739:Testosterone; D017430:Prostate-Specific Antigen