title: Detection of drugs of abuse in saliva by surface-enhanced Raman spectroscopy (SERS).
abstract: Eighty drugs of abuse and metabolites were successfully measured by surface-enhanced Raman spectroscopy (SERS) using gold- and silver-doped sol-gels immobilized in glass capillaries. A method was developed that provided consistent detection of 50 ppb cocaine in saliva in a focused study. This general method was successfully applied to the detection of a number of additional drugs in saliva, such as amphetamine, diazepam, and methadone.
authors.affiliation: Real-Time Analyzers, Inc., 362 Industrial Park Rd #8, Middletown, Connecticut 06457, USA.
authors.forename: Frank
authors.initials: F
authors.lastname: Inscore
authors.forename: Chetan
authors.initials: C
authors.lastname: Shende
authors.forename: Atanu
authors.initials: A
authors.lastname: Sengupta
authors.forename: Hermes
authors.initials: H
authors.lastname: Huang
authors.forename: Stuart
authors.initials: S
authors.lastname: Farquharson
mesh_terms: D006046:Gold / Q000737:chemistry; D006801:Humans; D013287:Illicit Drugs / Q000032:analysis*; D012372:ROC Curve; D012463:Saliva / Q000737:chemistry*; D012834:Silver / Q000737:chemistry; D013059:Spectrum Analysis, Raman / Q000379:methods*
chemical_list: D013287:Illicit Drugs; D012834:Silver; D006046:Gold