title: Copper-catalyzed trifluoromethylation of terminal alkenes through allylic C-H bond activation.
abstract: An unprecedented type of reaction for Cu-catalyzed trifluoromethylation of terminal alkenes is reported. This reaction represents a rare instance of catalytic trifluoromethylation through C(sp(3))-H activation. It also provides a mechanistically unique example of Cu-catalyzed allylic C-H activation/functionalization. Both experimental and theoretical analyses indicate that the trifluoromethylation may occur via a Heck-like four-membered-ring transition state.
authors.affiliation: Department of Chemistry, Joint Laboratory of Green Synthetic Chemistry, University of Science and Technology of China, Hefei 230026, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.forename: Yao
authors.initials: Y
authors.lastname: Fu
authors.forename: Dong-Fen
authors.initials: DF
authors.lastname: Luo
authors.forename: Yuan-Ye
authors.initials: YY
authors.lastname: Jiang
authors.forename: Bin
authors.initials: B
authors.lastname: Xiao
authors.forename: Zhao-Jing
authors.initials: ZJ
authors.lastname: Liu
authors.forename: Tian-Jun
authors.initials: TJ
authors.lastname: Gong
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*; D008745:Methylation; D008958:Models, Molecular; D008968:Molecular Conformation
chemical_list: D000475:Alkenes; D002244:Carbon; D003300:Copper; D006859:Hydrogen