title: Chemical constituents of Cichorium intybus and their inhibitory effects against urease and alpha-chymotrypsin enzymes.
abstract: Phytochemical investigation of the aerial parts of Cichorium intybus L. resulted in the isolation and identification of two new natural metabolites, 2,6-di[but-3(E)-en-2-onyl]naphthalene (1), and 3,3',4,4'-tetrahydroxychalcone (2), along with nine known compounds. Their structures were determined by spectroscopic techniques including 1D and 2D NMR. The known compounds were identified as scopoletin (3), 4-hydroxyphenylacetic acid (4), 3-hydroxy-4-methoxybenzoic acid (5), 4,4'-dihydroxychalcone (6), 6,7-dihydroxycoumarine (7), 1-triacontanol (8), lupeol (9), beta-sitosterol (10), and beta-sitosterol-3-O-beta-glucopyranoside (11). Compounds 4-6 and 8 are reported for the first time from C. intybus. Compounds 2 and 3 showed weak inhibitory activities against urease and alpha-chymotrypsin enzymes, respectively.
authors.affiliation: Department of Chemistry, University of Karachi, Karachi-75270, Pakistan. sumayyas@uok.edu.pk
authors.forename: Sumayya
authors.initials: S
authors.lastname: Saied
authors.forename: Shazia
authors.initials: S
authors.lastname: Shah
authors.forename: Zulfiqar
authors.initials: Z
authors.lastname: Ali
authors.forename: Ajmal
authors.initials: A
authors.lastname: Khan
authors.forename: Bishnu P
authors.initials: BP
authors.lastname: Marasini
authors.forename: Muhammad Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D018651:Cichorium intybus / Q000737:chemistry*; D002918:Chymotrypsin / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D014510:Urease / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D010936:Plant Extracts; D002918:Chymotrypsin; C117608:alpha-chymotrypsin; D014510:Urease