title: Associations of serotonergic genes with poststroke emotional incontinence.
abstract: OBJECTIVE
  Poststroke emotional incontinence (PSEI) has been associated with serotonergic dysfunction. Polymorphisms of serotonin transporter (5-HTT) and serotonin 2a receptor (5-HTR2a) genes may regulate serotonergic signaling at brain synapses, and this study was to investigate associations with PSEI in an East Asian population.
  
  
  METHODS
  In 276 stroke cases, PSEI was diagnosed by Kim's criteria. Covariates included age, gender, education, history of depression or stroke, current depression, and stroke severity and location. Genotypes were ascertained for 5-HTT gene-linked promoter region (5-HTTLPR), serotonin transporter intron 2 variable number tandem repeat, 5-HTR2a 1438A/G, and 5-HTR2a 102 T/C. Associations with PSEI were estimated by using logistic regression models, and gene-gene interactions were investigated by using the generalized multifactor dimensionality reduction method.
  
  
  RESULTS
  PSEI was present in 37 (13.4%) patients. The 5-HTT gene-linked promoter region s/s genotype was independently associated with PSEI. No associations with STin2 VNTR and 5-HTR2a genes were found, and no significant gene-gene interactions were identified.
  
  
  CONCLUSIONS
  Stroke patients with 5-HTTLPR s allele had higher susceptibility to PSEI, which underlines the potential role of serotonergic pathways in its etiology.
authors.affiliation: Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea. jmkim@chonnam.ac.kr
authors.forename: Jae-Min
authors.initials: JM
authors.lastname: Kim
authors.forename: Robert
authors.initials: R
authors.lastname: Stewart
authors.forename: Hee-Ju
authors.initials: HJ
authors.lastname: Kang
authors.forename: Kyung-Yeol
authors.initials: KY
authors.lastname: Bae
authors.forename: Sung-Wan
authors.initials: SW
authors.lastname: Kim
authors.forename: Il-Seon
authors.initials: IS
authors.lastname: Shin
authors.forename: Joon-Tae
authors.initials: JT
authors.lastname: Kim
authors.forename: Man-Seok
authors.initials: MS
authors.lastname: Park
authors.forename: Ki-Hyun
authors.initials: KH
authors.lastname: Cho
authors.forename: Jin-Sang
authors.initials: JS
authors.lastname: Yoon
mesh_terms: D000328:Adult; D000342:Affective Symptoms / Q000235:genetics*; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D020521:Stroke / Q000235:genetics / Q000523:psychology*
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins