title: Nuclear hormone receptor co-repressors: structure and function.
abstract: Co-repressor proteins, such as SMRT and NCoR, mediate the repressive activity of unliganded nuclear receptors and other transcription factors. They appear to act as intrinsically disordered "hub proteins" that integrate the activities of a range of transcription factors with a number of histone modifying enzymes. Although these co-repressor proteins are challenging targets for structural studies due to their largely unstructured character, a number of structures have recently been determined of co-repressor interaction regions in complex with their interacting partners. These have yielded considerable insight into the mechanism of assembly of these complexes, the structural basis for the specificity of the interactions and also open opportunities for targeting these interactions therapeutically.
authors.affiliation: Henry Wellcome Laboratories of Structural Biology, Department of Biochemistry, University of Leicester, Leicester LE1 9HN, UK.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Watson
authors.forename: Louise
authors.initials: L
authors.lastname: Fairall
authors.forename: John W R
authors.initials: JW
authors.lastname: Schwabe
mesh_terms: D000818:Animals; D004789:Enzyme Activation; D005786:Gene Expression Regulation; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans; D046912:Multiprotein Complexes / Q000737:chemistry; D056971:Nuclear Receptor Co-Repressor 1 / Q000378:metabolism*; D056985:Nuclear Receptor Co-Repressor 2 / Q000378:metabolism*; D011485:Protein Binding; D054730:Protein Interaction Domains and Motifs; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*
chemical_list: D046912:Multiprotein Complexes; D056971:Nuclear Receptor Co-Repressor 1; D056985:Nuclear Receptor Co-Repressor 2; D018160:Receptors, Cytoplasmic and Nuclear; D006655:Histone Deacetylases