title: Embolization of intracranial aneurysms with HydroSoft coils: results of the Korean multicenter study.
abstract: OBJECTIVE
  Various modifications of detachable coils have been attempted to reduce recurrence rates in aneurysmal coil embolization and HydroSoft coil is one of them. The authors report their experience using HydroSoft coils in the treatment of cerebral aneurysms.
  
  
  METHODS
  The present study is a prospective multicenter observational series of 127 aneurysms in 120 patients treated with HydroSoft coils.
  
  
  RESULTS
  Ten centers participated in this study, and there were 92 (72%) unruptured and 35 ruptured aneurysms. Aneurysm volumes were ≥ 100 mm³ in 21 (17%) and < 100 mm³ in 106 (83%) (mean, 56 mm³; range, 5-249 mm³). The average percentage length of HydroSoft coils detached in treated aneurysms was 67% (range, 42%-100%). Immediate postprocedural angiography demonstrated complete aneurysm occlusion in 69% (87/127 aneurysms), residual neck in 20% (25/127), and residual sac in 12% (15/127). Procedure-related adverse events occurred in 4.7% (6/127 aneurysms), including procedural bleeding (5/127) and thromboembolism (2/127), and immediate procedure-related morbidity and mortality rates were 0.8% and 0%. Conventional angiography or MRA follow-up was performed in 83% (105/127) at ≥ 6 months after treatment (mean interval, 11 months; range, 6-24 months). The overall recanalization rate was 3% (3/105 aneurysms; 2 major and 1 minor recanalizations). Progression to complete aneurysmal occlusion was noted in 20 of 27 aneurysms (74%) during the follow-up.
  
  
  CONCLUSIONS
  The safety profile of HydroSoft coils appears acceptable. In terms of initial occlusion rates and durability, embolization by using HydroSoft coils seems to be favorable compared with most large series of pure platinum or coated coils.
authors.affiliation: Department of Neurosurgery, Kangwon National University College of Medicine, Chuncheon, Korea.
authors.forename: J H
authors.initials: JH
authors.lastname: Park
authors.forename: H-S
authors.initials: HS
authors.lastname: Kang
authors.forename: M H
authors.initials: MH
authors.lastname: Han
authors.forename: P
authors.initials: P
authors.lastname: Jeon
authors.forename: D-S
authors.initials: DS
authors.lastname: Yoo
authors.forename: T H
authors.initials: TH
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017542:Aneurysm, Ruptured / Q000473:pathology / Q000628:therapy*; D002533:Cerebral Angiography; D004621:Embolization, Therapeutic / Q000295:instrumentation* / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002532:Intracranial Aneurysm / Q000473:pathology / Q000628:therapy*; D019344:Lactic Acid; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D011091:Polyesters; D011100:Polyglycolic Acid; D011108:Polymers; D011446:Prospective Studies; D012042:Registries; D056910:Republic of Korea; D016896:Treatment Outcome
chemical_list: D011091:Polyesters; D011108:Polymers; D011100:Polyglycolic Acid; D019344:Lactic Acid; C033616:poly(lactide)