title: Significant relationship between platelet activation and apnea-hypopnea index in patients with obstructive sleep apnea syndrome.
abstract: Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for arterial thrombosis, which is associated with high cardiovascular morbidity and mortality. To investigate the possible involvement of activated platelets, we evaluated the relationship between severity of OSAS and appearance of platelet aggregates (a marker of activated platelets) in 35 OSAS patients. Platelet aggregates were quantitatively determined by means of flow cytometry. There was a significant correlation between platelet aggregates and apnea-hypopnea index in the severe (AHI≥30 events/hour) group (r=0.756, p<0.001), but not in the mild-moderate (5≤AHI<30 events/hour) group (r=-0.032, p=0.905). The results indicate that the appearance of platelet aggregates increases with an increase in the severity of OSAS.
authors.affiliation: Department of Pulmonary Medicine, Tokai University Oiso Hospital, and Department of Neurology, Tokai University School of Medicine, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kondo
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kuwahira
authors.forename: Mie
authors.initials: M
authors.lastname: Shimizu
authors.forename: Asuka
authors.initials: A
authors.lastname: Nagai
authors.forename: Tokuzen
authors.initials: T
authors.lastname: Iwamoto
authors.forename: Sakurako
authors.initials: S
authors.lastname: Kato
authors.forename: Naoki
authors.initials: N
authors.lastname: Hayama
authors.forename: Takuya
authors.initials: T
authors.lastname: Aoki
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Urano
authors.forename: Fumihito
authors.initials: F
authors.lastname: Yoshii
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Abe
mesh_terms: D000328:Adult; D015992:Body Mass Index; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D015539:Platelet Activation / Q000502:physiology*; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology; D012892:Sleep Deprivation / Q000097:blood / Q000453:epidemiology / Q000209:etiology; D013927:Thrombosis / Q000097:blood / Q000453:epidemiology / Q000209:etiology
chemical_list: D010100:Oxygen