title: Toward magnetic resonance-guided electroanatomical voltage mapping for catheter ablation of scar-related ventricular tachycardia: a comparison of registration methods.
abstract: BACKGROUND
  Integration of preprocedural delayed enhanced magnetic resonance imaging (DE-MRI) with electroanatomical voltage mapping (EAVM) may provide additional high-resolution substrate information for catheter ablation of scar-related ventricular tachycardias (VT). Accurate and fast image integration of DE-MRI with EAVM is desirable for MR-guided ablation.
  
  
  RESULTS
  Twenty-six VT patients with large transmural scar underwent catheter ablation and preprocedural DE-MRI. With different registration models and EAVM input, 3 image integration methods were evaluated and compared to the commercial registration module CartoMerge. The performance was evaluated both in terms of distance measure that describes surface matching, and correlation measure that describes actual scar correspondence. Compared to CartoMerge, the method that uses the translation-and-rotation model and high-density EAVM input resulted in a registration error of 4.32±0.69 mm as compared to 4.84 ± 1.07 (P <0.05); the method that uses the translation model and high-density EAVM input resulted in a registration error of 4.60 ± 0.65 mm (P = NS); and the method that uses the translation model and a single anatomical landmark input resulted in a registration error of 6.58 ± 1.63 mm (P < 0.05). No significant difference in scar correlation was observed between all 3 methods and CartoMerge (P = NS).
  
  
  CONCLUSIONS
  During VT ablation procedures, accurate integration of EAVM and DE-MRI can be achieved using a translation registration model and a single anatomical landmark. This model allows for image integration in minimal mapping time and is likely to reduce fluoroscopy time and increase procedure efficacy.
authors.affiliation: Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands. q.tao@lumc.nl
authors.forename: Qian
authors.initials: Q
authors.lastname: Tao
authors.forename: Julien
authors.initials: J
authors.lastname: Milles
authors.forename: Carine
authors.initials: C
authors.lastname: VAN Huls VAN Taxis
authors.forename: Hildo J
authors.initials: HJ
authors.lastname: Lamb
authors.forename: Johan H C
authors.initials: JH
authors.lastname: Reiber
authors.forename: Katja
authors.initials: K
authors.lastname: Zeppenfeld
authors.forename: Rob J
authors.initials: RJ
authors.lastname: VAN DER Geest
mesh_terms: D000200:Action Potentials; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D059925:Anatomic Landmarks; D017115:Catheter Ablation; D003198:Computer Simulation; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D009203:Myocardial Infarction / Q000150:complications* / Q000473:pathology; D009206:Myocardium / Q000473:pathology*; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D017180:Tachycardia, Ventricular / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D013997:Time Factors; D056969:Voltage-Sensitive Dye Imaging
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA