title: Lobophytones U - Z₁, biscembranoids from the Chinese soft coral Lobophytum pauciflorum.
abstract: Chemical examination of a Chinese soft coral Lobophytum pauciflorum resulted in the isolation of seven new biscembranoids named lobophytones U-Z(1) (1-7, resp.), together with methyl sartortuoate (8) and nyalolide (9). The structures of the new compounds were elucidated by 1D- and 2D-NMR (COSY, HSQC, HMBC, and NOESY) spectroscopic analysis in association with MS and IR data. All compounds were tested against lipopolysaccharide (LPS)-induced nitric oxide (NO) release in mouse peritoneal macrophage. Lobophytone Z (6) inhibited NO production with an IC(50) value of 2.6 μM. Lobophytone H (1) showed inhibitory activities against the bacteria S. aureus and S. pneumoniae.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, P. R. China.
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Yan
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Deng
authors.forename: Leen
authors.initials: L
authors.lastname: van Ofwegen
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
authors.forename: Wenhan
authors.initials: W
authors.lastname: Lin
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002681:China; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000633:toxicity; D017737:Macrophages, Peritoneal / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D008826:Microbial Sensitivity Tests; D009569:Nitric Oxide / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes; D008070:Lipopolysaccharides; D009569:Nitric Oxide