title: Effects of concurrent training on interleukin-6, tumour necrosis factor-alpha and C-reactive protein in middle-aged men.
abstract: The purpose of this study was to evaluate the effects of moderate- to high-intensity resistance and concurrent training on inflammatory biomarkers and functional capacity in sedentary middle-aged healthy men. Participants were selected on a random basis for resistance training (n = 12), concurrent training (n = 11) and a control group (n = 13). They performed three weekly sessions for 16 weeks (resistance training: 10 exercises with 3 × 8-10 repetition maximum; concurrent training: 6 exercises with 3 × 8-10 repetition maximum, followed by 30 minutes of walking or running at 55-85% [Vdot]O(2peak)). Maximal strength was tested in bench press and leg press. The peak oxygen uptake ([Vdot]O(2peak)) was measured by an incremental exercise test. Tumour necrosis factor-α, interleukin-6 and C-reactive protein were determined. The upper- and lower-body maximal strength increase for both resistance (+42.52%; +20.9%, respectively) and concurrent training (+28.35%; +21.5%, respectively) groups (P = 0.0001).[Vdot]O(2peak) increased in concurrent training when comparing pre- and post-training (P = 0.0001; +15.6%). No differences were found in tumour necrosis factor-α and interleukin-6 for both groups after the exercise. C-reactive protein increased in resistance training (P = 0.004). These findings demonstrated that 16 weeks of moderate- to high-intensity training could improve functional capacity, but did not decrease inflammatory biomarkers in middle-aged men.
authors.affiliation: School of Physical Education, University of Campinas - UNICAMP, Campinas, Brazil. cleiton.libardi@hotmail.com
authors.forename: Cleiton Augusto
authors.initials: CA
authors.lastname: Libardi
authors.forename: Giovana Verginia
authors.initials: GV
authors.lastname: Souza
authors.forename: Arthur Fernandes
authors.initials: AF
authors.lastname: Gáspari
authors.forename: Claudinei Ferreira
authors.initials: CF
authors.lastname: Dos Santos
authors.forename: Sabrina Toffoli
authors.initials: ST
authors.lastname: Leite
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Dias
authors.forename: Anelena B
authors.initials: AB
authors.lastname: Frollini
authors.forename: Diego Trevisan
authors.initials: DT
authors.lastname: Brunelli
authors.forename: Claudia Regina
authors.initials: CR
authors.lastname: Cavaglieri
authors.forename: Vera Aparecida
authors.initials: VA
authors.lastname: Madruga
authors.forename: Mara P T
authors.initials: MP
authors.lastname: Chacon-Mikahil
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy / Q000379:methods*; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology; D010101:Oxygen Consumption; D010807:Physical Endurance / Q000502:physiology*; D055070:Resistance Training / Q000009:adverse effects; D012420:Running / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D016138:Walking / Q000502:physiology
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein