title: [Analysis of brain activity during delayed matching-to-sample test].
abstract: Despite recent advances in uncovering the neural signature of memory processing in humans, spatiotemporal characteristics of cerebral activity during mental transformation of the visual (color) memory to the visuo-spatial memory has not been studied. The aim of this study was to investigate the electrophysiological correlates of internal memory transformation based on the event-related potential analysis using a root mean square (RMS) and a standardized low resolution electromagnetic tomography (sLORETA). Eleven healthy human subjects completed a modified delayed matching-to-sample test in which the visual(color) short-term memory had to be transformed into the visuo-spatial memory according to the matching probe. In comparison with a non-memory control condition, identifiable RMS peak was observed 352ms after the matching probe presentation in the condition of memory transformation. In this time, sLORETA demonstrated the higher current density in the prefrontal region. Our results suggested that the prefrontal region is associated with the internal memory transformation process depicting a spatiotemporal profile similar to P3b.
authors.affiliation: Department of Central Clinical Laboratory, Kanazawa University Hospital. nanbu-knz@umin.ac.jp
authors.forename: Yuko
authors.initials: Y
authors.lastname: Nanbu
authors.forename: Yui
authors.initials: Y
authors.lastname: Kikuchi
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Kikuchi
authors.forename: Mitsugu
authors.initials: M
authors.lastname: Yoneda
authors.forename: Masaie
authors.initials: M
authors.lastname: Seki
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Nagasawa
authors.forename: Toshiji
authors.initials: T
authors.lastname: Takamura
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Sakai
authors.forename: Takashi
authors.initials: T
authors.lastname: Wada
mesh_terms: D000328:Adult; D004569:Electroencephalography; D005074:Evoked Potentials, Visual / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D017397:Prefrontal Cortex / Q000502:physiology*; D055815:Young Adult