title: Characterization of phenazone transformation products on light-activated TiO2 surface by high-resolution mass spectrometry.
abstract: The paper examines the transformation of phenazone (2,3-dimethyl-1-phenyl-3-pyrazolin-5-one), a widely used analgesic and antipyretic drug, under simulated solar irradiation in pure water, using titanium dioxide, and in river water. High-resolution mass spectrometry was employed to monitor the evolution of photoinduced processes. Initially, laboratory experiments were performed to simulate drug-transformation pathways in aqueous solution, using TiO(2) as photocatalyst. Thirteen main phenazone transformation products were detected, and full analysis of their MS and MS(n) spectra identified the diverse isobaric species. All these transformation products were themselves easily degraded, and no compounds were recognized to remain until 1h of irradiation. From these findings, a tentative degradation pathway is proposed to account for the photoinduced transformation of phenazone in natural waters. These simulation experiments were verified in the field, seeking phenazone in River Po water samples.
authors.affiliation: Department of Analytical Chemistry, Università degli Studi di Torino, Via P. Giuria 5, 10125 Torino, Italy. paola.calza@unito.it
authors.forename: P
authors.initials: P
authors.lastname: Calza
authors.forename: C
authors.initials: C
authors.lastname: Medana
authors.forename: E
authors.initials: E
authors.lastname: Raso
authors.forename: V
authors.initials: V
authors.lastname: Giancotti
authors.forename: C
authors.initials: C
authors.lastname: Minero
mesh_terms: D000983:Antipyrine / Q000737:chemistry* / Q000528:radiation effects* / Q000633:toxicity; D006900:Hydroxylation; D008027:Light; D013058:Mass Spectrometry / Q000379:methods*; D010782:Photolysis; D045483:Rivers / Q000737:chemistry; D014025:Titanium / Q000737:chemistry*; D018675:Toxicity Tests; D014867:Water / Q000737:chemistry; D014874:Water Pollutants, Chemical / Q000737:chemistry / Q000633:toxicity
chemical_list: D014874:Water Pollutants, Chemical; D014867:Water; C009495:titanium dioxide; D014025:Titanium; D000983:Antipyrine