title: Validation of the web-based LUMINA questionnaire for recruiting large cohorts of migraineurs.
abstract: OBJECTIVE
  To assess validity of a self-administered web-based migraine-questionnaire in diagnosing migraine aura for the use of epidemiological and genetic studies.
  
  
  METHODS
  Self-reported migraineurs enrolled via the LUMINA website and completed a web-based questionnaire on headache and aura symptoms, after fulfilling screening criteria. Diagnoses were calculated using an algorithm based on the International Classification of Headache Disorders (ICHD-2), and semi-structured telephone-interviews were performed for final diagnoses. Logistic regression generated a prediction rule for aura. Algorithm-based diagnoses and predicted diagnoses were subsequently compared to the interview-derived diagnoses.
  
  
  RESULTS
  In 1 year, we recruited 2397 migraineurs, of which 1067 were included in the validation. A seven-question subset provided higher sensitivity (86% vs. 45%), slightly lower specificity (75% vs. 95%), and similar positive predictive value (86% vs. 88%) in assessing aura when comparing with the ICHD-2-based algorithm.
  
  
  CONCLUSIONS
  This questionnaire is accurate and reliable in diagnosing migraine aura among self-reported migraineurs and enables detection of more aura cases with low false-positive rate.
authors.affiliation: Leiden University, The Netherlands.
authors.forename: W P J
authors.initials: WP
authors.lastname: van Oosterhout
authors.forename: C M
authors.initials: CM
authors.lastname: Weller
authors.forename: A H
authors.initials: AH
authors.lastname: Stam
authors.forename: F
authors.initials: F
authors.lastname: Bakels
authors.forename: T
authors.initials: T
authors.lastname: Stijnen
authors.forename: M D
authors.initials: MD
authors.lastname: Ferrari
authors.forename: G M
authors.initials: GM
authors.lastname: Terwindt
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000465:Algorithms; D019540:Area Under Curve; D015331:Cohort Studies; D005260:Female; D006801:Humans; D038801:International Classification of Diseases; D020407:Internet; D007407:Interviews as Topic; D008297:Male; D008875:Middle Aged; D020325:Migraine with Aura / Q000175:diagnosis*; D008962:Models, Theoretical; D009426:Netherlands; D018579:Patient Selection; D011237:Predictive Value of Tests; D012372:ROC Curve; D015203:Reproducibility of Results; D012494:Sampling Studies; D057566:Self Report; D011795:Surveys and Questionnaires; D055815:Young Adult