title: [Comparison of the hemostatic efficiency of Ankaferd Blood Stopper and fibrin glue on a liver laceration model in rats].
abstract: BACKGROUND
  Ankaferd Blood Stopper® (ABS) is an organic topical hemostatic agent that has become available in recent years. The aim of this study was to compare the effectiveness of ABS in a liver laceration model in rats with that of fibrin glue (FG), which is currently being used widely in clinics.
  
  
  METHODS
  Thirty-two Wistar Albino type rats were randomly divided into four groups. In the Sham group (Group 1), only the liver was explored. In the other study groups (Groups 2, 3 and 4), three incisions were performed, each 1 cm long and 2 mm deep, on the front of the left lobe of the livers. In Groups 2 and 3, ABS and FG were used as hemostatic agents, respectively. No materials were used for the injuries in the Control Group (Group 4). Bleeding periods, changes in the hematocrit levels, intraabdominal adhesion levels, and histopathological effects were taken into consideration.
  
  
  RESULTS
  There was no significant difference between the period of hemostasis in Groups 2 and 3, whereas the same period was evidently longer in Group 4 (17 (15-20) sec, 18 (16-20) sec, 70 (64-74) seconds, respectively; p<0.05). No significant difference was detected between the groups regarding intraabdominal adhesion levels (Group 1: 1 (0-1), Group 2: 2 (1-3), Group 3: 2 (1-3), Group 4: 2 (1-3); p>0.05). Microscopic evaluations revealed similar histopathological effects of ABS and FG on the liver and surrounding tissues (p>0.05).
  
  
  CONCLUSIONS
  The topical hemostatic effectiveness of ABS was shown to be comparable to FG in a liver laceration model in rats. There was no significant difference between these materials regarding adhesion formation in intraabdominal use or histopathological effects.
authors.affiliation: Department of General Surgery, Okmeydanı Training and Research Hospital, İstanbul, Turkey.
authors.forename: Cevher
authors.initials: C
authors.lastname: Akarsu
authors.forename: Mustafa Uygar
authors.initials: MU
authors.lastname: Kalaycı
authors.forename: Erkan
authors.initials: E
authors.lastname: Yavuz
authors.forename: Selvinaz
authors.initials: S
authors.lastname: Ozkara
authors.forename: Berk
authors.initials: B
authors.lastname: Gökçek
authors.forename: Yaşar
authors.initials: Y
authors.lastname: Ozdenkaya
authors.forename: Orhan
authors.initials: O
authors.lastname: Yalçın
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006470:Hemorrhage / Q000517:prevention & control*; D006490:Hemostatics / Q000494:pharmacology*; D022125:Lacerations / Q000150:complications; D008099:Liver / Q000098:blood supply / Q000187:drug effects / Q000293:injuries*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D006490:Hemostatics; D010936:Plant Extracts; C539751:ankaferd blood stopper