title: Applicability of radiocolloids, blue dyes and fluorescent indocyanine green to sentinel node biopsy in melanoma.
abstract: Patients with primary cutaneous melanoma underwent sentinel node (SN) mapping and biopsy at 25 facilities in Japan by the combination of radiocolloid with gamma probe and dye. Technetium-99m ((99m)Tc)-tin colloid, (99m)Tc-phytate, 2% patent blue violet (PBV) and 0.4% indigo carmine were used as tracers. In some hospitals, 0.5% fluorescent indocyanine green, which allows visualization of the SN with an infrared camera, was concomitantly used and examined. A total of 673 patients were enrolled, and 562 cases were eligible. The detection rates of SN were 95.5% (147/154) with the combination of tin colloid and PBV, 98.9% (368/372) with the combination of phytate and PBV, and 97.2% (35/36) with the combination of tin colloid or phytate and indigo carmine. SN was not detected in 12 cases by the combination method, and the primary tumor was in the head and neck in six of those 12 cases. In eight of 526 cases (1.5%), SN was detected by PBV but not by radiocolloid. There were 13 cases (2.5%) in which SN was detected by radiocolloid but not by PBV. In 18 of 36 cases (50%), SN was detected by radiocolloid but not by indigo carmine. Concomitantly used fluorescent indocyanine green detected SN in all of 67 cases. Interference with transcutaneous oximetry by PVB was observed in some cases, although it caused no clinical trouble. Allergic reactions were not reported with any of the tracers. (99m)Tc-tin colloid, (99m)Tc-phytate, PBV and indocyanine green are useful tracers for SN mapping.
authors.affiliation: Department of Dermatology, Shinshu University School of Medicine, Asahi, Matsumoto, Japan. uhara@shinshu-u.ac.jp
authors.forename: Hisashi
authors.initials: H
authors.lastname: Uhara
authors.forename: Naoya
authors.initials: N
authors.lastname: Yamazaki
authors.forename: Minoru
authors.initials: M
authors.lastname: Takata
authors.forename: Yuji
authors.initials: Y
authors.lastname: Inoue
authors.forename: Akihiro
authors.initials: A
authors.lastname: Sakakibara
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Keisuke
authors.initials: K
authors.lastname: Suehiro
authors.forename: Akifumi
authors.initials: A
authors.lastname: Yamamoto
authors.forename: Riei
authors.initials: R
authors.lastname: Kamo
authors.forename: Kosuke
authors.initials: K
authors.lastname: Mochida
authors.forename: Hideya
authors.initials: H
authors.lastname: Takenaka
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Yamashita
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Takenouchi
authors.forename: Shusuke
authors.initials: S
authors.lastname: Yoshikawa
authors.forename: Akira
authors.initials: A
authors.lastname: Takahashi
authors.forename: Jiro
authors.initials: J
authors.lastname: Uehara
authors.forename: Mikio
authors.initials: M
authors.lastname: Kawai
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Iwata
authors.forename: Takafumi
authors.initials: T
authors.lastname: Kadono
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Kai
authors.forename: Shoichi
authors.initials: S
authors.lastname: Watanabe
authors.forename: Satoru
authors.initials: S
authors.lastname: Murata
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ikeda
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Fukamizu
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Tanaka
authors.forename: Naohito
authors.initials: N
authors.lastname: Hatta
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Saida
mesh_terms: D004396:Coloring Agents; D005456:Fluorescent Dyes; D006258:Head and Neck Neoplasms; D006801:Humans; D007208:Indocyanine Green; D008207:Lymphatic Metastasis / Q000175:diagnosis* / Q000000981:diagnostic imaging*; D008545:Melanoma / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000556:secondary*; D015609:Organotechnetium Compounds; D010833:Phytic Acid; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012394:Rosaniline Dyes; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*; D012878:Skin Neoplasms; D013667:Technetium; D017556:Technetium Compounds; D017971:Tin Compounds
chemical_list: D004396:Coloring Agents; D005456:Fluorescent Dyes; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D012394:Rosaniline Dyes; D017556:Technetium Compounds; D017971:Tin Compounds; C033493:technetium Tc 99m tin colloid; C026177:technetium phytate; D013667:Technetium; D010833:Phytic Acid; C008769:sulfan blue; D007208:Indocyanine Green