title: Osteoprotegerin gene polymorphism in diabetic Charcot neuroarthropathy.
abstract: OBJECTIVE
  Recently, an association between two polymorphisms (1181G>C and 245T>G) of the osteoprotegerin (OPG) gene and diabetic Charcot neuroarthropathy was suggested on the basis of studies of a limited number of samples derived from subjects from one geographical region (Italy). The aim of this study was to assess the presence of various osteoprotegerin gene polymorphisms in patients with diabetes and Charcot neuroarthropathy compared with subjects with diabetic neuropathy but no Charcot foot and healthy controls from another geographical region (Poland).
  
  
  METHODS
  DNA was isolated from 54 patients with Charcot neuroarthropathy, 35 subjects with diabetic neuropathy but no Charcot foot, and 95 healthy controls to evaluate OPG gene polymorphisms and their possible contribution to the development of Charcot neuroarthropathy.
  
  
  RESULTS
  Statistically significant differences between the group of subjects with neuropathy but no Charcot neuroarthropathy and the control group were found for 1217C>T, 950T>C and 245T>G polymorphisms, between the group of patients with Charcot neuroarthropathy and the control group for 1181G>C and 950T>C polymorphisms, and between the group of subjects with neuropathy but no Charcot neuroarthropathy and the group of patients with Charcot neuroarthropathy for 1217C>T and 245T>G polymorphisms.
  
  
  CONCLUSIONS
  We suggest that genetic factors, particularly OPG gene polymorphisms, may play a role in the development of diabetic Charcot neuroarthropathy.
authors.affiliation: Department of Diabetology and Hypertension, Medical University of Gdańsk, Gdańsk, Poland. akorzon@wp.pl
authors.forename: A
authors.initials: A
authors.lastname: Korzon-Burakowska
authors.forename: J
authors.initials: J
authors.lastname: Jakóbkiewicz-Banecka
authors.forename: A
authors.initials: A
authors.lastname: Fiedosiuk
authors.forename: N
authors.initials: N
authors.lastname: Petrova
authors.forename: T
authors.initials: T
authors.lastname: Koblik
authors.forename: M
authors.initials: M
authors.lastname: Gabig-Cimińska
authors.forename: M
authors.initials: M
authors.lastname: Edmonds
authors.forename: M T
authors.initials: MT
authors.lastname: Małecki
authors.forename: G
authors.initials: G
authors.lastname: Węgrzyn
mesh_terms: D000328:Adult; D001177:Arthropathy, Neurogenic / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D003929:Diabetic Neuropathies / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D053244:Osteoprotegerin / Q000097:blood / Q000235:genetics*; D011044:Poland / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide
chemical_list: D053244:Osteoprotegerin