title: Deep hypothermic circulatory arrest: alternative strategies for cerebral perfusion. A review article.
abstract: Deep hypothermic circulatory arrest is an essential tool in the surgeon's armamentarium. There are essentially three strategies to address cerebral ischemia during arrest periods. Early surgical case series pioneered the option of complete anoxia with deep hypothermia. Subsequent innovators introduced the concept of retrograde perfusion of the cerebral vessels through the venous system, and others have advocated the use of selective and non-selective antegrade perfusion of the cerebral arteries. Clinical studies assessing outcomes of the three approaches are compromised by small patient numbers, retrospective design and surgeon bias. In this review, the authors will briefly discuss the conceptual basis of these strategies and the literature comparing these approaches in terms of key neurologic outcomes. The importance of this topic will emphasize the key role the perfusion community plays in establishing guidelines for best practice in circulatory arrest to go forward with education and research in this area.
authors.affiliation: Division of Cardiac Surgery, the Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
authors.forename: E M
authors.initials: EM
authors.lastname: Elmistekawy
authors.forename: F D
authors.initials: FD
authors.lastname: Rubens
mesh_terms: D002545:Brain Ischemia / Q000209:etiology / Q000517:prevention & control*; D002536:Cerebral Arteries; D002560:Cerebrovascular Circulation; D050792:Circulatory Arrest, Deep Hypothermia Induced / Q000009:adverse effects / Q000193:education / Q000379:methods*; D002986:Clinical Trials as Topic; D006801:Humans; D017410:Practice Guidelines as Topic; D015424:Reperfusion / Q000009:adverse effects / Q000379:methods*