title: TRIMming Flavivirus infection.
abstract: Tripartite motif (TRIM) proteins are novel players in antiviral innate immunity. In this issue of Cell Host & Microbe,Taylor et al. (2011) discover the mechanism of action of TRIM79α and show that this interferon-induced protein restricts tick-borne flaviviruses by targeting the viral polymerase for degradation.
authors.affiliation: Department of Microbiology and Immunobiology, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA. michaela_gack@hms.harvard.edu
authors.forename: Michaela U
authors.initials: MU
authors.lastname: Gack