title: Coordinated increase in serum platelet-derived growth factor-BB and transforming growth factor-β1 in patients with chronic pancreatitis.
abstract: BACKGROUND
  In vitro studies suggest that platelet-derived growth factor-BB (PDGF-BB) and transforming growth factor-β1 (TGF-β1) play an important role in pancreatic fibrosis. The aim of this study was to evaluate serum PDGF-BB and TGF-β1 concentrations in patients with chronic pancreatitis (CP).
  
  
  METHODS
  Forty male patients with a history of alcoholic CP and 35 age-matched healthy subjects were examined. Serum concentrations of PDGF-BB, TGF-β1, laminin and hyaluronic acid were determined by ELISA assay. Additionally, we determined serum concentrations of PDGF-BB and TGF-β1 in patients with functional dyspepsia, ulcerative colitis and Crohn's disease.
  
  
  RESULTS
  Patients with advanced CP had significantly higher serum PDGF-BB and TGF-β1 concentrations compared to control subjects. A strong positive correlation between serum PDGF-BB and TGF-β1 concentrations was found in patients with CP. Serum laminin and hyaluronic acid were also elevated in patients with CP. No increase in serum PDGF-BB and TGF-β1 concentrations was found in patients with functional dyspepsia, ulcerative colitis or Crohn's disease.
  
  
  CONCLUSIONS
  The obtained results indicate for the first time that serum levels of PDGF-BB are elevated in patients with CP. However, ROC curve analysis suggests that PDGF-BB is not superior to laminin as a potential marker of advanced CP.
authors.affiliation: Department of Gastroenterology and Hepatology, Medical University of Gdansk, Gdansk, Poland.
authors.forename: Krystian
authors.initials: K
authors.lastname: Adrych
authors.forename: Marian
authors.initials: M
authors.lastname: Smoczynski
authors.forename: Magdalena
authors.initials: M
authors.lastname: Stojek
authors.forename: Tomasz
authors.initials: T
authors.lastname: Sledzinski
authors.forename: Justyna
authors.initials: J
authors.lastname: Korczynska
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Goyke
authors.forename: Julian
authors.initials: J
authors.lastname: Swierczynski
mesh_terms: D000328:Adult; D000077214:Becaplermin; D015415:Biomarkers / Q000097:blood; D003093:Colitis, Ulcerative / Q000097:blood / Q000175:diagnosis; D003424:Crohn Disease / Q000097:blood / Q000175:diagnosis; D004415:Dyspepsia / Q000097:blood / Q000175:diagnosis; D006801:Humans; D007797:Laminin / Q000097:blood; D008297:Male; D008875:Middle Aged; D019512:Pancreatitis, Alcoholic / Q000097:blood* / Q000175:diagnosis; D020574:Proto-Oncogene Proteins c-sis / Q000097:blood*; D053773:Transforming Growth Factor beta1 / Q000097:blood*
chemical_list: D015415:Biomarkers; D007797:Laminin; D020574:Proto-Oncogene Proteins c-sis; C508960:TGFB1 protein, human; D053773:Transforming Growth Factor beta1; D000077214:Becaplermin