title: [Present state and prospects of adjuvant chemotherapy for gastric cancer].
abstract: In Japan, a one-year administration of S-1 is the standard adjuvant treatment for stage II/III gastric cancer after curative gastrectomy with a D2 lymph-node dissection.The treatment is recommended in the Japanese Guidelines for Treatment of Gastric Cancer(3rd Edition).Using data from results of a 5-year follow-up of the ACTS-GC trial, it was confirmed that using S-1 significantly improves the 5-year overall survival over surgery alone.However, the recurrence rate of stage III gastric cancer is still too high.More powerful treatment using multiple drugs is needed for this disease.This paper presents a new perspective for the development of post-operative adjuvant chemotherapy in the future, based on clinical trials recently reported.
authors.affiliation: Upper GI Surgery Division, Dept. of Surgery, Hyogo College of Medicine.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Hori
authors.forename: Rie
authors.initials: R
authors.lastname: Ozawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hanayama
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Yamashita
authors.forename: Noriaki
authors.initials: N
authors.lastname: Kaibe
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Oshima
authors.forename: Masashi
authors.initials: M
authors.lastname: Takemura
authors.forename: Shojiro
authors.initials: S
authors.lastname: Kikuchi
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Sasako
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D006801:Humans; D009367:Neoplasm Staging; D010094:Oxonic Acid / Q000627:therapeutic use; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000627:therapeutic use
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid