title: Toxicological responses of Cyprinus carpio exposed to a commercial formulation containing glyphosate.
abstract: The effects of commercial glyphosate herbicide formulation on the activity of acetylcholinesterase (AChE) enzyme and oxidative stress were studied in Cyprinus carpio exposed for 96 h to 0.0, 0.5, 2.5, 5.0 and 10.0 mg/L and then allowed to equal recovery period in water without herbicide. The activity of AChE was inhibited in the brain and in the muscle after exposure. However, after recovery period brain and muscle AChE activity increased. Brain thiobarbituric acid reactive species (TBARS) were measured as an indicator of oxidative stress. Increased TBARS levels were observed with all concentrations tested of the glyphosate formulation, and remained increased after the recovery period. The results recorded clearly indicate lipid peroxidation and anti-AChE action induced by Roundup(®) exposure.
authors.affiliation: Programa de Pós-graduação em Bioquímica Toxicológica, UFSM, Santa Maria, RS, Brazil.
authors.forename: Roberta
authors.initials: R
authors.lastname: Cattaneo
authors.forename: Bárbara
authors.initials: B
authors.lastname: Clasen
authors.forename: Vania Lucia
authors.initials: VL
authors.lastname: Loro
authors.forename: Charlene Cavalheiro
authors.initials: CC
authors.lastname: de Menezes
authors.forename: Alexandra
authors.initials: A
authors.lastname: Pretto
authors.forename: Bernardo
authors.initials: B
authors.lastname: Baldisserotto
authors.forename: Adriana
authors.initials: A
authors.lastname: Santi
authors.forename: Luis Antonio
authors.initials: LA
authors.lastname: de Avila
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002347:Carps / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004784:Environmental Monitoring / Q000379:methods; D005998:Glycine / Q000031:analogs & derivatives* / Q000633:toxicity; D006540:Herbicides / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D009132:Muscles / Q000187:drug effects / Q000201:enzymology; D018384:Oxidative Stress / Q000187:drug effects; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D000097797:Glyphosate
chemical_list: D000110:Acetylcholinesterase; D005998:Glycine; D006540:Herbicides; D017392:Thiobarbituric Acid Reactive Substances; D014874:Water Pollutants, Chemical; D000097797:Glyphosate