title: Cancer in inflammatory bowel disease 15 years after diagnosis in a population-based European Collaborative follow-up study.
abstract: OBJECTIVE
  To determine the occurrence of intestinal and extraintestinal cancers in the 1993-2009 prospective European Collaborative Inflammatory Bowel Disease (EC-IBD) Study Group cohort.
  
  
  METHODS
  A physician per patient form was completed for 681 inflammatory bowel disease patients (445UC/236CD) from 9 centers (7 countries) derived from the original EC-IBD cohort. For the 15-year follow up period, rates of detection of intestinal and extraintestinal cancers were computed.
  
  
  RESULTS
  Patient follow-up time was fifteen years. In total 62/681 patients (9.1%) [41 with ulcerative colitis/21 with Crohn's disease, 36 males/26 females] were diagnosed with sixty-six cancers (four patients with double cancers). Colorectal cancer was diagnosed in 9/681 patients [1.3%] (1 Crohn's disease and 8 ulcerative colitis). The remaining 53 cancers were extraintestinal. There was a higher prevalence of intestinal cancer in the Northern centers compared to Southern centers [p=NS]. Southern centers had more cases of extraintestinal cancer compared to Northern centers [p=NS]. The frequency of all observed types of cancers in Northern and in Southern centers did not differ compared to the expected one in the background population.
  
  
  CONCLUSIONS
  In the fifteen-year follow up of the EC-IBD Study Group cohort the prevalence of cancer was 9.1% with most patients having a single neoplasm and an extraintestinal neoplasm. In Northern centers there were more intestinal cancers while in Southern centers there were more extraintestinal cancers compared to Northern centers. In this IBD cohort the frequency of observed cancers was not different from that expected in the background population.
authors.affiliation: Department of Hepato-Gastroenterology, Medical School of Ioannina, Greece.
authors.forename: Konstantinos H
authors.initials: KH
authors.lastname: Katsanos
authors.forename: Athina
authors.initials: A
authors.lastname: Tatsioni
authors.forename: Natalia
authors.initials: N
authors.lastname: Pedersen
authors.forename: Mary
authors.initials: M
authors.lastname: Shuhaibar
authors.forename: Vicent Hernandez
authors.initials: VH
authors.lastname: Ramirez
authors.forename: Patrizia
authors.initials: P
authors.lastname: Politi
authors.forename: Evelien
authors.initials: E
authors.lastname: Rombrechts
authors.forename: Marieke
authors.initials: M
authors.lastname: Pierik
authors.forename: Juan
authors.initials: J
authors.lastname: Clofent
authors.forename: Marina
authors.initials: M
authors.lastname: Beltrami
authors.forename: Paolo
authors.initials: P
authors.lastname: Bodini
authors.forename: Joao
authors.initials: J
authors.lastname: Freitas
authors.forename: Ioannis
authors.initials: I
authors.lastname: Mouzas
authors.forename: Giovanni
authors.initials: G
authors.lastname: Fornaciari
authors.forename: Bjorn
authors.initials: B
authors.lastname: Moum
authors.forename: Peter Laszlo
authors.initials: PL
authors.lastname: Lakatos
authors.forename: Severine
authors.initials: S
authors.lastname: Vermeire
authors.forename: Ebbe
authors.initials: E
authors.lastname: Langholz
authors.forename: Selwyn
authors.initials: S
authors.lastname: Odes
authors.forename: Colm O'
authors.initials: CO
authors.lastname: Morain
authors.forename: Reinhold
authors.initials: R
authors.lastname: Stockbrügger
authors.forename: Pia
authors.initials: P
authors.lastname: Munkholm
authors.forename: Epameinondas V
authors.initials: EV
authors.lastname: Tsianos
mesh_terms: D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000209:etiology; D005060:Europe / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications*; D008297:Male; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology*; D015995:Prevalence