title: New clinical scoring system for prognosis of early recurrence of colorectal liver metastases after surgical treatment.
abstract: OBJECTIVE
  To determine the relationship between the mRNA expression of MMP-2, MMP-9, TIMP-1, TIMP-2 and CEA in tumour tissue and preoperative serum levels of these tumour markers in patients with colorectal liver metastases (CLM). Additionally, to establish a new scoring system based upon these results in combination with the volume of the metastatic process to identify patients with a high risk of early recurrence of CLM.
  
  
  METHODS
  The correlation between the mRNA expression of CEA, TIMP-1, TIMP-2, MMP-2 and MMP-9 in tissue samples and preoperative serum levels of the named tumour markers was performed on 27 patients. The scoring system was proposed as a combination of all the independent parameters (mRNA expression of TIMP-1, MMP-9 and CEA in tumour tissue samples and preoperative serum levels of CEA and TIMP-1) in combination with the volume of the metastatic process. The evaluation was conducted in relation to the disease free interval (DFI).
  
  
  RESULTS
  We observed a statistically significant relationship between the volume of liver metastases and DFI (p<0.0337). The scoring system divided the patients into groups with a tendency of early recurrence (p<0.0126).
  
  
  CONCLUSIONS
  The high stages in our scoring systems augment the risk of recurrence. The proposed scoring system was shown to be an efficient instrument helpful in complex surgical and oncological access to patients after radical surgical treatment of CLM.
authors.affiliation: Department of Surgery, Charles University, Prague, Czech Republic.
authors.forename: Sutnar
authors.initials: S
authors.lastname: Alan
authors.forename: Liska
authors.initials: L
authors.lastname: Vaclav
authors.forename: Pesta
authors.initials: P
authors.lastname: Martin
authors.forename: Treska
authors.initials: T
authors.lastname: Vladislav
authors.forename: Topolcan
authors.initials: T
authors.lastname: Ondrej
authors.forename: Skalicky
authors.initials: S
authors.lastname: Tomas
authors.forename: Kormunda
authors.initials: K
authors.lastname: Stanislav
authors.forename: Holubec
authors.initials: H
authors.lastname: Lubos
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002272:Carcinoembryonic Antigen / Q000235:genetics; D015179:Colorectal Neoplasms / Q000473:pathology*; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D020778:Matrix Metalloproteinase 2 / Q000235:genetics; D020780:Matrix Metalloproteinase 9 / Q000235:genetics; D008875:Middle Aged; D011379:Prognosis; D012333:RNA, Messenger / Q000032:analysis; D012008:Recurrence; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000235:genetics; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000235:genetics
chemical_list: D002272:Carcinoembryonic Antigen; D012333:RNA, Messenger; D019715:Tissue Inhibitor of Metalloproteinase-1; D019716:Tissue Inhibitor of Metalloproteinase-2; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9