title: Connexins in epidermal homeostasis and skin disease.
abstract: The expression of multiple connexin (Cx) types in the epidermis, their differential expression during wound closure and the association of skin pathology with specific Cx gene mutations, are indicative of important functions for Cxs in the skin. In this review, we focus on the role of Cx proteins in the epidermis and during wound healing and discuss mutations in Cx genes which cause skin disease. This article is part of a Special Issue entitled: The Communicating junctions, composition, structure and characteristics.
authors.affiliation: Queen Mary University of London, London, UK.
authors.forename: Claire A
authors.initials: CA
authors.lastname: Scott
authors.forename: Daniel
authors.initials: D
authors.lastname: Tattersall
authors.forename: Edel A
authors.initials: EA
authors.lastname: O'Toole
authors.forename: David P
authors.initials: DP
authors.lastname: Kelsell
mesh_terms: D000818:Animals; D000072259:Connexin 26; D000075302:Connexin 30; D018031:Connexin 43 / Q000378:metabolism; D017630:Connexins / Q000378:metabolism*; D019465:Craniofacial Abnormalities / Q000235:genetics; D004476:Ectodermal Dysplasia / Q000235:genetics; D004817:Epidermis / Q000378:metabolism*; D056266:Erythrokeratodermia Variabilis / Q000235:genetics; D005124:Eye Abnormalities / Q000235:genetics; D005532:Foot Deformities, Congenital / Q000235:genetics; D006706:Homeostasis; D006801:Humans; D015603:Keratinocytes / Q000166:cytology; D008954:Models, Biological; D009154:Mutation; D012871:Skin Diseases / Q000378:metabolism*; D013576:Syndactyly / Q000235:genetics; D014071:Tooth Abnormalities / Q000235:genetics; D014945:Wound Healing; D014981:Xenopus
chemical_list: D000075302:Connexin 30; D018031:Connexin 43; D017630:Connexins; C491020:GJB6 protein, human; D000072259:Connexin 26