title: ZYM-201 sodium succinate ameliorates streptozotocin-induced hyperlipidemic conditions.
abstract: ZYM-201 is a methyl ester of a novel triterpenoid glycoside. It is isolated from SANGUISORBA OFFICINALIS, a widely used medicinal plant in Korea, China, and Japan, that is prescribed for various diseases such as diarrhea, chronic intestinal infections, duodenal ulcers, and bleeding. In this study, the antihyperlipidemic effect of the salt form (sodium succinate) of ZYM-201 was examined using streptozotocin (STZ)-treated hyperglycemic rats. Oral administration of ZYM-201 sodium succinate (3 to 10 mg/kg) resulted in recovery of the increased serum levels of triglyceride (TG) and total cholesterol (TC) back to normal levels. Elevated levels of serum lipoproteins, such as high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL), were also significantly restored by this compound without altering 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase activity. Finally, ZYM-201 sodium succinate displayed antioxidative properties, including suppression of lipid peroxide and hydroxyl radical generation and upregulation of superoxide dismutase (SOD) activity. Therefore, our data strongly suggest that ZYM-201 sodium succinate can be used as a remedy for the treatment of diabetes-derived hyperlipidemic disorders such as atherosclerosis and vascular diseases.
authors.affiliation: College of Pharmacy, Kyungsung University, Busan, Korea.
authors.forename: Jongwon
authors.initials: J
authors.lastname: Choi
authors.forename: Mi-Yeon
authors.initials: MY
authors.lastname: Kim
authors.forename: Bae Cheon
authors.initials: BC
authors.lastname: Cha
authors.forename: Eun Sook
authors.initials: ES
authors.lastname: Yoo
authors.forename: Keejung
authors.initials: K
authors.lastname: Yoon
authors.forename: Jaehwi
authors.initials: J
authors.lastname: Lee
authors.forename: Ho Sik
authors.initials: HS
authors.lastname: Rho
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Jae Youl
authors.initials: JY
authors.lastname: Cho
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D048909:Diabetes Complications / Q000097:blood / Q000188:drug therapy; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D017665:Hydroxyl Radical / Q000378:metabolism; D006949:Hyperlipidemias / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D015227:Lipid Peroxidation / Q000187:drug effects; D008055:Lipids / Q000097:blood; D008297:Male; D008517:Phytotherapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D031993:Sanguisorba / Q000737:chemistry*; D013311:Streptozocin; D013482:Superoxide Dismutase / Q000378:metabolism; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D000960:Hypolipidemic Agents; D008055:Lipids; D014315:Triterpenes; C568212:ZYM-201 sodium succinate; D017665:Hydroxyl Radical; D013311:Streptozocin; D013482:Superoxide Dismutase