title: Insights into matriptase-2 substrate binding and inhibition mechanisms by analyzing active-site-mutated variants.
authors.affiliation: Pharmazeutisches Institut, Universität Bonn, Bonn, Germany.
authors.forename: Eva
authors.initials: E
authors.lastname: Maurer
authors.forename: Mihiret T
authors.initials: MT
authors.lastname: Sisay
authors.forename: Marit
authors.initials: M
authors.lastname: Stirnberg
authors.forename: Torsten
authors.initials: T
authors.lastname: Steinmetzer
authors.forename: Jürgen
authors.initials: J
authors.lastname: Bajorath
authors.forename: Michael
authors.initials: M
authors.lastname: Gütschow
mesh_terms: D000595:Amino Acid Sequence; D020134:Catalytic Domain; D057809:HEK293 Cells; D006801:Humans; D008565:Membrane Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008958:Models, Molecular; D016297:Mutagenesis, Site-Directed; D009154:Mutation; D010455:Peptides / Q000737:chemistry / Q000378:metabolism; D011480:Protease Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D012697:Serine Endopeptidases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D013379:Substrate Specificity
chemical_list: D008565:Membrane Proteins; D010455:Peptides; D011480:Protease Inhibitors; D012697:Serine Endopeptidases; C467801:matriptase 2