title: Aloe vera extract reduces both growth and germ tube formation by Candida albicans.
abstract: Due to the increased number of immunocompromised patients, the infections associated with the pathogen of the genus Candida have significantly increased in recent years. To grow, Candida albicans may form a germ tube extension from the cells, which is essential for virulence. In this work, we studied the effect of crude glycolic extract of Aloe vera fresh leaves (20% w/v) on growth and germ tube formation by C. albicans. The C. albicans growth was determined in the presence of different concentrations of A. vera extracts in Sabouraud dextrose broth medium. In the presence of A. vera extract (10% v/v), the pronounced inhibition in the C. albicans growth (90-100%) was observed. This inhibition occurred parallel to the decrease in the germ tube formation induced by goat serum. Our results demonstrated that A. vera fresh leaves plant extract can inhibit both the growth and the germ tube formation by C. albicans. Our results suggest the possibility that A. vera extract may be used as a promising novel antifungal treatment.
authors.affiliation: Universidade do Vale do Paraí ba-UNIVAP, Instituto de Pesquisa e Desenvolvimento-IP&D, Av. Shishima Hifumi, São José dos Campos, SP, Brazil.
authors.forename: Ivy
authors.initials: I
authors.lastname: Bernardes
authors.forename: Monalisa Poliana
authors.initials: MP
authors.lastname: Felipe Rodrigues
authors.forename: Gabrielle Klug
authors.initials: GK
authors.lastname: Bacelli
authors.forename: Egberto
authors.initials: E
authors.lastname: Munin
authors.forename: Leandro Procópio
authors.initials: LP
authors.lastname: Alves
authors.forename: Maricilia Silva
authors.initials: MS
authors.lastname: Costa
mesh_terms: D000504:Aloe / Q000737:chemistry*; D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development*; D015536:Down-Regulation; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D013172:Spores, Fungal / Q000187:drug effects / Q000254:growth & development
chemical_list: D000935:Antifungal Agents; D010936:Plant Extracts