title: Use of inactivated Escherichia coli enterotoxins to enhance respiratory mucosal adjuvanticity during vaccination in swine.
abstract: In order to augment responses to respiratory vaccines in swine, various adjuvants were intranasally coadministered with a foot-and-mouth disease virus (FMDV) antigen to pigs. Detoxified Escherichia coli enterotoxins LTK63 and LTR72 enhanced antigen-specific mucosal and systemic immunity, demonstrating their efficacy as adjuvants for nonreplicating antigens upon intranasal immunization in swine.
authors.affiliation: Department of Animal Science, University of Connecticut, Storrs, Connecticut 06269, USA.
authors.forename: Roger W
authors.initials: RW
authors.lastname: Barrette
authors.forename: Steven M
authors.initials: SM
authors.lastname: Szczepanek
authors.forename: Debra
authors.initials: D
authors.lastname: Rood
authors.forename: Sreerupa
authors.initials: S
authors.lastname: Challa
authors.forename: Naomi
authors.initials: N
authors.lastname: Avery
authors.forename: Michael
authors.initials: M
authors.lastname: Vajdy
authors.forename: Ed
authors.initials: E
authors.lastname: Kramer
authors.forename: Luis
authors.initials: L
authors.lastname: Rodriguez
authors.forename: Lawrence K
authors.initials: LK
authors.lastname: Silbart
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000281:Administration, Intranasal; D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D001427:Bacterial Toxins / Q000008:administration & dosage* / Q000235:genetics; D001769:Blood / Q000276:immunology; D004768:Enterotoxins / Q000008:administration & dosage* / Q000235:genetics; D029968:Escherichia coli Proteins / Q000008:administration & dosage* / Q000235:genetics; D005536:Foot-and-Mouth Disease / Q000276:immunology / Q000517:prevention & control*; D029544:Foot-and-Mouth Disease Virus / Q000276:immunology*; D018928:Immunity, Mucosal; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000097:blood; D013552:Swine; D014121:Toxoids / Q000008:administration & dosage* / Q000235:genetics; D014611:Vaccination / Q000379:methods*; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D001427:Bacterial Toxins; D004768:Enterotoxins; D029968:Escherichia coli Proteins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D014121:Toxoids; D014765:Viral Vaccines; C027538:heat-labile enterotoxin, E coli