title: Hydrocephalus and spinal cord tumors: a review.
abstract: BACKGROUND
  Hydrocephalus secondary to intraspinal tumors is a well-known but rare condition since about 1% of patients with spinal cord tumors have various degrees of hydrocephalus at initial presentation.
  
  
  CONCLUSIONS
  The mechanism of development of intracranial hypertension and hydrocephalus in patients with spinal cord tumor is not exactly known. The problematic aspects of this condition, with regard to clinical presentation and pathophysiology, are discussed and the relevant literature is reviewed. This uncommon association should always be kept in mind in the differential diagnosis of hydrocephalus of unknown etiology for three main reasons: the possibility of neurological deterioration if the patient is shunted prior tumor removal, the possibility to treat the hydrocephalus without shunting by simply removing the tumor, and the possible role of hydrocephalus as an early sign of intracranial metastasis in patients previously operated upon for removal of intramedullary gliomas. Due to the very slow evolution of the disease, a careful and close clinical and neuroradiological follow-up are essential for many years afterward. The presence of intracranial hypertension in a patient previously operated for a spinal tumor should be considered and investigated as an early sign of neoplastic intracranial seeding.
authors.affiliation: Department of Pediatric Neurosurgery, Santobono Children's Hospital, Via Mario Fiore n. 6, 80129 Naples, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Mirone
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Cinalli
authors.forename: Pietro
authors.initials: P
authors.lastname: Spennato
authors.forename: Claudio
authors.initials: C
authors.lastname: Ruggiero
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Aliberti
mesh_terms: D005340:Fibrinogen / Q000134:cerebrospinal fluid; D006801:Humans; D006849:Hydrocephalus / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D019586:Intracranial Hypertension / Q000209:etiology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D019635:Neurosurgical Procedures / Q000379:methods; D013120:Spinal Cord Neoplasms / Q000150:complications* / Q000175:diagnosis; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D005340:Fibrinogen