title: Effect of testosterone replacement treatment in testosterone deficiency syndrome patients with metabolic syndrome.
abstract: OBJECTIVE
  This study was conducted to investigate the effect of testosterone replacement treatment (TRT) in testosterone deficiency syndrome (TDS) patients with metabolic syndrome.
  
  
  METHODS
  We reviewed the data of 200 men who were diagnosed with TDS and were undergoing TRT between August 2006 and August 2009. The 200 patients were divided into two groups (group 1: 71 patients with metabolic syndrome, group 2: 129 patients without metabolic syndrome) depending on metabolic syndrome, which was diagnosed according to the NCEP III criteria for Asians. Age, BMI (body mass index), waist circumference, serologic tests, AMS (the Aging Males' Symptoms scale), and IIEF (International Index of Erectile Function) were measured.
  
  
  RESULTS
  In group 1, waist circumference and fasting glucose were significantly decreased; hemoglobin and total testosterone were increased; and the somatovegetative scale score of the AMS, the total AMS score, the erectile function score of the IIEF, the overall satisfaction score of the IIEF, and the total IIEF score were significantly improved after TRT. On the other hand, in group 2, waist circumference, BMI, total cholesterol, LDL, and fasting glucose were significantly decreased; hemoglobin and total testosterone were increased; and the 2 subscale scores of the AMS (psychologic and somatovegetative), the total AMS score, all subscale scores of the IIEF, and the total IIEF score were significantly improved after TRT.
  
  
  CONCLUSIONS
  Overall, the patients who had TDS with metabolic syndrome showed less improvement in AMS, IIEF, and serum variables. Therefore, the correction of metabolic syndrome, such as diabetes, obesity, and hypertension, should be considered during TRT.
authors.affiliation: Department of Urology, Korea University College of Medicine, Korea.
authors.forename: Seung Min
authors.initials: SM
authors.lastname: Jeong
authors.forename: Byeong Kuk
authors.initials: BK
authors.lastname: Ham
authors.forename: Min Gu
authors.initials: MG
authors.lastname: Park
authors.forename: Mi Mi
authors.initials: MM
authors.lastname: Oh
authors.forename: Duck Ki
authors.initials: DK
authors.lastname: Yoon
authors.forename: Je Jong
authors.initials: JJ
authors.lastname: Kim
authors.forename: Du Geon
authors.initials: du G
authors.lastname: Moon