title: Treatment of encapsulated blebs with slit-lamp needling and subconjunctival interferon injection.
abstract: OBJECTIVE
  To investigate the efficacy and safety of slit-lamp needle revision with subconjunctival interferon injection in eyes with encapsulated blebs.
  
  
  METHODS
  We reviewed a series of 25 cases (27 eyes) in which primary needling with 5×105 IFN α-2b injection was performed for bleb encapsulation and analysed the results over a follow-up period of at least 12 months.
  
  
  RESULTS
  The mean time to development of encapsulated blebs after the surgery was 23.85 ± 10.66 days (9 to 60 days). The mean IOP decreased significantly from 22.51 ± 5.30 mm Hg at diagnosis of encapsulated blebs to 17.26±7.72 mmHg at the last visit (P = 0.009). Of the 27 eyes, 15 (55.56%) achieved a successful result, 10 (37.04%) were qualified for success and the remaining 2 (7.4%) were considered as failure. The qualified success group took 1.70 ± 0.67 antiglaucoma medications. No serious complications were detected.
  
  
  CONCLUSIONS
  The needling procedure associated with subconjuctival injection of IFN α-2b is a safe and effective method in treating encapsulated blebs.
authors.affiliation: State Key Laboratory on Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat -sen University, Guangzhou, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Mao
authors.forename: Xing
authors.initials: X
authors.lastname: Liu
authors.forename: Yimin
authors.initials: Y
authors.lastname: Zhong
authors.forename: Dan
authors.initials: D
authors.lastname: Cao
authors.forename: Mei
authors.initials: M
authors.lastname: Li
authors.forename: Fenfen
authors.initials: F
authors.lastname: Yu
mesh_terms: D001768:Blister / Q000628:therapy*; D003228:Conjunctiva; D005123:Eye; D005260:Female; D006801:Humans; D056965:Injections, Intraocular; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000008:administration & dosage; D012086:Reoperation; D014656:Vascular Surgical Procedures
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins