title: Microsomal prostaglandin e synthase-1 in rheumatic diseases.
abstract: Microsomal prostaglandin E synthase-1 (mPGES-1) is a well-recognized target for the development of novel anti-inflammatory drugs that can reduce symptoms of inflammation in rheumatic diseases and other inflammatory conditions. In this review, we focus on mPGES-1 in rheumatic diseases with the aim to cover the most recent advances in the understanding of mPGES-1 in rheumatoid arthritis, osteoarthritis, and inflammatory myopathies. Novel findings regarding regulation of mPGES-1 cell expression as well as enzyme inhibitors are also summarized.
authors.affiliation: Rheumatology Unit, Department of Medicine, Karolinska Institutet Stockholm, Sweden.
authors.forename: Marina
authors.initials: M
authors.lastname: Korotkova
authors.forename: Per-Johan
authors.initials: PJ
authors.lastname: Jakobsson