title: Comparative analysis of clinical, biochemical and genetic aspects associated with bone mineral density in small for gestational age children.
abstract: Clinical, biochemical and genetic analysis related to bone mineral density (BMD) were carried out in children born small for gestational age (SGA) that failed to achieve postnatal catch-up growth (CUG), SGA children that completed CUG and adequate for gestational age (AGA) children. Serum IGF-I, IGF-II, IGF binding protein-3 and acid-labile subunit were lower in the SGA-CUG children as compared with the other groups. Frequencies of polymorphic variants of vitamin D receptor, estrogen receptor and collagen genes were similar among groups. The genotype 194-192 of the IGF-I gene was higher in the SGA-CUG and 196-192 was higher in the SGA+CUG group. In the SGA-CUG group, the genotype SS of the COLIA1 gene was associated with lower BMD. Therefore, IGF system and COLIA1 polymorphism distinguish prepubertal SGA-CUG children from the SGA+CUG children of the same age. Furthermore, COLIA1 polymorphism could be useful to predict osteopenia in SGA-CUG children.
authors.affiliation: Servicio de Endocrinología, Hospital de Niños de la Santísima Trinidad, Córdoba, Argentina.
authors.forename: Liliana
authors.initials: L
authors.lastname: Silvano
authors.forename: Mirta
authors.initials: M
authors.lastname: Miras
authors.forename: Adriana
authors.initials: A
authors.lastname: Pérez
authors.forename: Gabriela
authors.initials: G
authors.lastname: Picotto
authors.forename: Gabriela
authors.initials: G
authors.lastname: Díaz de Barboza
authors.forename: Liliana
authors.initials: L
authors.lastname: Muñoz
authors.forename: Silvia
authors.initials: S
authors.lastname: Martin
authors.forename: Gabriela
authors.initials: G
authors.lastname: Sobrero
authors.forename: Pedro
authors.initials: P
authors.lastname: Armelini
authors.forename: Verónica
authors.initials: V
authors.lastname: Mericq
authors.forename: Nori
authors.initials: N
authors.lastname: Tolosa de Talamoni
mesh_terms: D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000175:diagnosis* / Q000209:etiology / Q000235:genetics*; D002352:Carrier Proteins / Q000097:blood; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D024042:Collagen Type I / Q000235:genetics; D000090602:Collagen Type I, alpha 1 Chain; D042241:Early Diagnosis; D005260:Female; D056726:Genetic Association Studies; D006023:Glycoproteins / Q000097:blood; D006130:Growth Disorders / Q000097:blood* / Q000235:genetics* / Q000503:physiopathology; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D007335:Insulin-Like Growth Factor II / Q000032:analysis; D008297:Male; D011110:Polymorphism, Genetic
chemical_list: D002352:Carrier Proteins; D024042:Collagen Type I; D000090602:Collagen Type I, alpha 1 Chain; D006023:Glycoproteins; C035170:IGF2 protein, human; D018972:Insulin-Like Growth Factor Binding Protein 3; C075944:insulin-like growth factor binding protein, acid labile subunit; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II