title: The genotoxic potentials of some atypical antipsychotic drugs on human lymphocytes.
abstract: Olanzapine (OLZ), risperidone (RPD) and quetiapine (QTP) are atypical antipsychotic drugs and are commonly used for the treatments of schizophrenia and bipolar disorders. However, recent reports indicated that these drugs could exhibit toxic effects on nervous and cardiovascular systems. To our best knowledge, there are scarce data considering the genotoxic damage potentials of OLZ, RPD and QTP on human lymphocyte culture system. Therefore, in this study, the genotoxic potentials of OLZ, RPD and QTP (0-400 mg/L) have been evaluated in human whole blood cultures (WBCs; n = 4). The single cell gel electrophoresis (SCGE) and micronucleus (MN) assays were applied to estimate the DNA damage. The results of the present study indicated that the tested antipsychotic drug did not induce genotoxicity. In fact, the mean values of the total scores of cells showing DNA damage (for SCGE assay) and MN/1000 cell were not found significantly different from the control values (p > 0.05). However, the application of the highest drug concentrations (250 mg/L and above) caused the sterility in lymphocyte cultures. It is concluded that the tested three different atypical antipsychotic drugs can be used safely, but it is necessary to consider the cytotoxic effects that are likely to appear depending on the doses exposed.
authors.affiliation: Faculty of Science, Biology Department, Atatürk University, Erzurum, Turkey. basaktogar@gmail.com
authors.forename: Basak
authors.initials: B
authors.lastname: Togar
authors.forename: Hasan
authors.initials: H
authors.lastname: Turkez
authors.forename: Abdulgani
authors.initials: A
authors.lastname: Tatar
authors.forename: Ismet
authors.initials: I
authors.lastname: Kirkpinar
authors.forename: Ahmet
authors.initials: A
authors.lastname: Hacimuftuoglu
authors.forename: Fatime
authors.initials: F
authors.lastname: Geyikoglu
authors.forename: M Sait
authors.initials: MS
authors.lastname: Keles
authors.forename: Ebubekir
authors.initials: E
authors.lastname: Dirican
mesh_terms: D000704:Analysis of Variance; D014150:Antipsychotic Agents / Q000633:toxicity*; D001569:Benzodiazepines / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D004249:DNA Damage; D003987:Dibenzothiazepines / Q000633:toxicity; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D000077152:Olanzapine; D000069348:Quetiapine Fumarate; D018967:Risperidone / Q000633:toxicity
chemical_list: D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D009153:Mutagens; D001569:Benzodiazepines; D000069348:Quetiapine Fumarate; D018967:Risperidone; D000077152:Olanzapine