title: [Cartilage changes of femoral head osteonecrosis in stage II and III as detected by dGEMRIC].
abstract: OBJECTIVE
  To detect the cartilage changes of hip joint with osteonecrosis of femoral head (ONFH) in stages II and III and provide evidence for understanding cartilage changes of femoral head of osteonecrosis before collapse.
  
  
  METHODS
  The cartilage changes of ONFH were determined by delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC). According to ARCO classification of ONFH, the samples were divided into three groups: Group A, 11 hips, stageII; Group B, 13 hips, stage III; Group C, 10 hips, normal. All participates underwent the tests by dGEMRIC. And the data of T1Gd were collected and analyzed.
  
  
  RESULTS
  The values of T1Gd were 420 ± 60 (Group A), 361 ± 54(Group B) and 538 ± 26 (Group C) respectively. There was a significant difference among three groups. The values of T1Gd in the ONFH patients were lower than their healthy counterparts. The values of TIGd of Group B was 14% lower than those of Group A. And the difference was significant statistically.
  
  
  CONCLUSIONS
  Cartilage of the femoral head undergoes abnormal metabolic changes before collapse. There is a loss of GAG in the cartilage and it aggravates with the worsening of ONFH.
authors.affiliation: Department of Orthopedics, China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Zhao-hui
authors.initials: ZH
authors.lastname: Liu
authors.forename: Wan-shou
authors.initials: WS
authors.lastname: Guo
authors.forename: Dong
authors.initials: D
authors.lastname: Yang
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.forename: Peng
authors.initials: P
authors.lastname: Peng
authors.forename: Li-ming
authors.initials: LM
authors.lastname: Cheng
authors.forename: Ran
authors.initials: R
authors.lastname: Ding
authors.forename: Qi-dong
authors.initials: QD
authors.lastname: Zhang
authors.forename: Zi-rong
authors.initials: ZR
authors.lastname: Li
mesh_terms: D000328:Adult; D002356:Cartilage / Q000473:pathology*; D016022:Case-Control Studies; D005260:Female; D005271:Femur Head Necrosis / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D055815:Young Adult