title: [Gastroprotective properties of gefarnate analogs with oxygen atoms in alcohol chain].
abstract: We assessed the effects of some gefarnate analogs on gastric ulcer prophylaxis (adrenaline ulcers) and ulcer healing (acetic ulcers) and some secretory parameters in rats. Acute ulcers were induced in male Wistar rats by intraperitoneal injection of 2 mg/kg adrenaline hydrochloride. Rats were killed after 24 hours. Chronic gastric ulcers were induced in rats by application of 100% acetic acid to the serosal surface of the stomach on 60 sec. Gefarnate analogs introduced intraperitoneally or intragastrically. Gefarnate analogs dose-dependently increase the healing of gastric ulcers and have a marked prophylaxis effects especially in the case of adrenaline ulcers.
authors.forename: N I
authors.initials: NI
authors.lastname: Belostotskiĭ
authors.forename: A G
authors.initials: AG
authors.lastname: Nigmatov
authors.forename: E P
authors.initials: EP
authors.lastname: Serebriakov
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005753:Gastric Mucosa / Q000187:drug effects; D005778:Gefarnate / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use*; D008297:Male; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry*; D051381:Rats; D013276:Stomach Ulcer / Q000517:prevention & control*; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000897:Anti-Ulcer Agents; D005778:Gefarnate; D010100:Oxygen