title: The parasite clearance curve.
abstract: Parasite clearance rates are important measures of anti-malarial drug efficacy. They are particularly important in the assessment of artemisinin resistance. The slope of the log-linear segment in the middle of the parasite clearance curve has the least inter-individual variance and is the focus of therapeutic assessment. The factors affecting parasite clearance are reviewed. Methods of presentation and the approaches to analysis are discussed.
authors.affiliation: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. nickw@tropmedres.ac
authors.forename: N J
authors.initials: NJ
authors.lastname: White
mesh_terms: D000962:Antimalarials / Q000008:administration & dosage; D037621:Artemisinins / Q000008:administration & dosage; D016903:Drug Monitoring / Q000379:methods*; D006801:Humans; D007783:Lactones / Q000008:administration & dosage; D008288:Malaria / Q000188:drug therapy* / Q000469:parasitology*; D018512:Parasitemia / Q000469:parasitology*; D010961:Plasmodium / Q000302:isolation & purification*
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D007783:Lactones; C075875:artemisin