title: Synthesis and 2D QSAR of O-sulphonated β-aminols derivatives as novel antifungal and antibacterial agents.
abstract: Synthesis of a series of β-aminol derivatives using regioselective opening reaction catalyzed by SiO(2) (60-120mesh) and O-sulphonation in THF-KOH system, comprising tert-butoxycarbonyl at secondary nitrogen and evaluate for various stains of bacteria and fungi. SAR study of synthesized compound using backward regression analysis.
authors.affiliation: Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226 001, India.
authors.forename: Sugandha
authors.initials: S
authors.lastname: Sharma
authors.forename: Atindra K
authors.initials: AK
authors.lastname: Pandey
authors.forename: Praveen K
authors.initials: PK
authors.lastname: Shukla
authors.forename: Anil K
authors.initials: AK
authors.lastname: Saxena
mesh_terms: D000605:Amino Alcohols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D021281:Quantitative Structure-Activity Relationship; D012044:Regression Analysis; D013450:Sulfones / Q000737:chemistry*
chemical_list: D000605:Amino Alcohols; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D013450:Sulfones