title: [Antibodies to native and denatured DNA in multiple sclerosis].
abstract: An aim of the present paper was to study antibodies to native and denatured DNA in the serum of patients with multiple sclerosis (MS). Sixty-two patients and 27 healthy people (controls) have been studied. The significantly higher levels of antibodies to native (56% of patients) and denatured (67% of patients) DNA were observed compared to controls. The higher levels of antibodies were found in patients with remitting MS compared to primarily- and secondary progressive MS. The results obtained support the hypothesis that anti-DNA antibodies to DNA are the key component of the pathogenesis and their level depends on the immunoreactivity of the patient and MS course.
authors.forename: V M
authors.initials: VM
authors.lastname: Alifirova
authors.forename: N V
authors.initials: NV
authors.lastname: Krotenko
authors.forename: N M
authors.initials: NM
authors.lastname: Krotenko
authors.forename: S A
authors.initials: SA
authors.lastname: Ivanova
mesh_terms: D000293:Adolescent; D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000276:immunology*; D009691:Nucleic Acid Denaturation; D055815:Young Adult
chemical_list: D000974:Antibodies, Antinuclear