title: [Effects of different neuromediators and regulatory peptides on the impulse activity of neurons in the superior vestibular nucleus].
abstract: The microelectrode technique and microiontophoresis of physiologically active substances in experiments with cats immobilized with the muscle relaxants made it clear that different classical neuromediators (acetylcholine, norepinephrine, gamma-aminobutyric acid (GABA) and others), as well as regulatory peptides (enkephalins, thyrotropin-releasing hormone (TRH), vasoactive interstitial peptide (VIP), somatostatin (SS) and others) can exert a direct effect on the majority (61 to 100%) of neurons in the superior vestibular nucleus (SVN). The inhibiting effect of enkephalins, VIP and SS on the neurons impulse activity remained essentially unchanged by L-glutamate. Also, enkephalins, VIP and SS were found to amplify the inhibiting action of GABA and glycine. Consequently, these substances can fulfill the role of SVN neuromediators and/or neuromodulators.
authors.forename: V V
authors.initials: VV
authors.lastname: Iasnetsov
authors.forename: V A
authors.initials: VA
authors.lastname: Pravdivtsev
authors.forename: V G
authors.initials: VG
authors.lastname: Motin
authors.forename: S K
authors.initials: SK
authors.lastname: Karsanova
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Ivanov
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D002415:Cats; D004347:Drug Interactions; D004745:Enkephalins / Q000494:pharmacology; D018698:Glutamic Acid / Q000494:pharmacology; D007103:Immobilization; D007478:Iontophoresis; D008297:Male; D008839:Microelectrodes; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D013004:Somatostatin / Q000494:pharmacology; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology; D014726:Vestibular Nuclei / Q000187:drug effects / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
chemical_list: D004745:Enkephalins; D018377:Neurotransmitter Agents; D014660:Vasoactive Intestinal Peptide; D018698:Glutamic Acid; D013004:Somatostatin; D005680:gamma-Aminobutyric Acid; D013973:Thyrotropin-Releasing Hormone; D000109:Acetylcholine