title: Norovirus gastroenteritis and seizures: an atypical case with neuroradiological abnormalities.
abstract: We describe an 8-year-old boy admitted because of prolonged seizures during norovirus gastroenteritis without any signs of encephalopathy. Blood tests were normal and cerebrospinal fluid examination resulted negative for both bacteria and viruses. A reverse transcriptase polymerase chain reaction revealed norovirus RNA in a stool sample. A cerebral computed tomography turned out to be normal whereas subsequent cerebral magnetic resonance imaging showed transitory signal abnormalities consistent with vasogenic edema. The post-ictal electroencephalogram revealed normal background activity with sporadic left posterior delta waves. The child was discharged after 10 days with an unremarkable physical examination. A cerebral magnetic resonance imaging and an electroencephalogram after 1 month were both negative. We report a new case of benign infantile convulsions due to norovirus gastroenteritis with neuroradiological abnormalities to the pertinent literature in order to improve knowledge about this disorder and increase the possibility of clarifying its pathogenesis.
authors.affiliation: Department of Pediatrics, University Hospital of Padua, Italy. dr.luca.bartolini@gmail.com
authors.forename: L
authors.initials: L
authors.lastname: Bartolini
authors.forename: R
authors.initials: R
authors.lastname: Mardari
authors.forename: I
authors.initials: I
authors.lastname: Toldo
authors.forename: M
authors.initials: M
authors.lastname: Calderone
authors.forename: P A
authors.initials: PA
authors.lastname: Battistella
authors.forename: A M
authors.initials: AM
authors.lastname: Laverda
authors.forename: S
authors.initials: S
authors.lastname: Sartori
mesh_terms: D017250:Caliciviridae Infections / Q000150:complications*; D002540:Cerebral Cortex / Q000503:physiopathology*; D002648:Child; D004569:Electroencephalography; D005759:Gastroenteritis / Q000150:complications / Q000209:etiology / Q000821:virology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D029322:Norovirus / Q000472:pathogenicity*; D012640:Seizures / Q000209:etiology* / Q000532:radiotherapy* / Q000821:virology; D014057:Tomography, X-Ray Computed