title: ASCertaining cytoskeletal rearrangements in antigen presentation and migration.
abstract: ASC has emerged as an adaptor for inflammasome sensors in cells of the innate immune response. New inflammasome-independent roles have been identified for ASC in the control of adaptive immunity; these include the post-transcriptional regulation of cytoskeletal rearrangements.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Karakasiliotis
authors.forename: Dimitris L
authors.initials: DL
authors.lastname: Kontoyiannis
mesh_terms: D000199:Actins / Q000737:chemistry*; D000818:Animals; D051017:Apoptosis Regulatory Proteins; D053468:CARD Signaling Adaptor Proteins; D003598:Cytoskeletal Proteins / Q000502:physiology*; D020690:GTPase-Activating Proteins / Q000502:physiology*; D020662:Guanine Nucleotide Exchange Factors; D058847:Inflammasomes / Q000502:physiology*; D020744:rac GTP-Binding Proteins / Q000378:metabolism*
chemical_list: D000199:Actins; D051017:Apoptosis Regulatory Proteins; D053468:CARD Signaling Adaptor Proteins; D003598:Cytoskeletal Proteins; C471356:DOCK2 protein, mouse; D020690:GTPase-Activating Proteins; D020662:Guanine Nucleotide Exchange Factors; D058847:Inflammasomes; C498534:Pycard protein, mouse; D020744:rac GTP-Binding Proteins