title: Intracellular events and cell fate in filovirus infection.
abstract: Marburg and Ebola viruses cause a severe hemorrhagic disease in humans with high fatality rates. Early target cells of filoviruses are monocytes, macrophages, and dendritic cells. The infection spreads to the liver, spleen and later other organs by blood and lymph flow. A hallmark of filovirus infection is the depletion of non-infected lymphocytes; however, the molecular mechanisms leading to the observed bystander lymphocyte apoptosis are poorly understood. Also, there is limited knowledge about the fate of infected cells in filovirus disease. In this review we will explore what is known about the intracellular events leading to virus amplification and cell damage in filovirus infection. Furthermore, we will discuss how cellular dysfunction and cell death may correlate with disease pathogenesis.
authors.affiliation: Department of Microbiology, School of Medicine, Boston University, Boston, MA 02118, USA. jolejnik@bu.edu
authors.forename: Judith
authors.initials: J
authors.lastname: Olejnik
authors.forename: Elena
authors.initials: E
authors.lastname: Ryabchikova
authors.forename: Ronald B
authors.initials: RB
authors.lastname: Corley
authors.forename: Elke
authors.initials: E
authors.lastname: Mühlberger
mesh_terms: D000818:Animals; D016923:Cell Death; D003588:Cytopathogenic Effect, Viral; D003713:Dendritic Cells / Q000821:virology; D016563:Filoviridae / Q000737:chemistry / Q000472:pathogenicity* / Q000502:physiology; D018702:Filoviridae Infections / Q000821:virology*; D016679:Genome, Viral; D054884:Host-Pathogen Interactions; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure; D008264:Macrophages / Q000821:virology; D046529:Microscopy, Electron, Transmission; D012367:RNA, Viral / Q000235:genetics*; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics; D014776:Virus Cultivation; D053586:Virus Internalization; D057074:Virus Release; D014779:Virus Replication
chemical_list: D012367:RNA, Viral; D014764:Viral Proteins