title: Similar VLDL-TG storage in visceral and subcutaneous fat in obese and lean women.
abstract: OBJECTIVE
  Excess visceral fat accumulation is associated with the metabolic disturbances of obesity. Differential lipid redistribution through lipoproteins may affect body fat distribution. This is the first study to investigate VLDL-triglyceride (VLDL-TG) storage in visceral fat.
  
  
  METHODS
  Nine upper-body obese (UBO; waist circumference >88 cm) and six lean (waist circumference <80 cm) women scheduled for elective tubal ligation surgery were studied. VLDL-TG storage in visceral, upper-body subcutaneous (UBSQ), and lower-body subcutaneous (LBSQ) fat were measured with [9,10-(3)H]-triolein-labeled VLDL.
  
  
  RESULTS
  VLDL-TG storage in visceral fat accounted for only ~0.8% of VLDL-TG turnover in UBO and lean women, respectively. A significantly larger proportion of VLDL-TG turnover was stored in UBSQ (~5%) and LBSQ (~4%) fat. The VLDL-TG fractional storage was similar in UBO and lean women for all regional depots. VLDL-TG fractional storage and VLDL-TG concentration were correlated in UBO women in UBSQ fat (r = 0.68, P = 0.04), whereas an inverse association was observed for lean women in visceral (r = -0.89, P = 0.02) and LBSQ (r = -0.87, P = 0.02) fat.
  
  
  CONCLUSIONS
  VLDL-TG storage efficiency is similar in all regional fat depots, and trafficking of VLDL-TG into different adipose tissue depots is similar in UBO and lean women. Postabsorptive VLDL-TG storage is unlikely to be of major importance in the development of preferential upper-body fat distribution in obese women.
authors.affiliation: Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Esben
authors.initials: E
authors.lastname: Søndergaard
authors.forename: Birgitte
authors.initials: B
authors.lastname: Nellemann
authors.forename: Lars P
authors.initials: LP
authors.lastname: Sørensen
authors.forename: Lars C
authors.initials: LC
authors.lastname: Gormsen
authors.forename: Jens S
authors.initials: JS
authors.lastname: Christiansen
authors.forename: Erik
authors.initials: E
authors.lastname: Ernst
authors.forename: Margit
authors.initials: M
authors.lastname: Dueholm
authors.forename: Søren
authors.initials: S
authors.lastname: Nielsen
mesh_terms: D017667:Adipocytes / Q000473:pathology; D050154:Adiposity; D000328:Adult; D000465:Algorithms; D001706:Biopsy; D015992:Body Mass Index; D048429:Cell Size; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000378:metabolism* / Q000473:pathology; D007700:Kinetics; D008079:Lipoproteins, VLDL / Q000097:blood / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism* / Q000473:pathology; D009928:Organ Specificity; D050151:Subcutaneous Fat / Q000378:metabolism* / Q000473:pathology; D013909:Thorax / Q000473:pathology; D014280:Triglycerides / Q000097:blood / Q000378:metabolism*; D014316:Tritium; D055105:Waist Circumference
chemical_list: D008079:Lipoproteins, VLDL; D014280:Triglycerides; C030106:very low density lipoprotein triglyceride; D014316:Tritium