title: Regeneration in an evolutionarily primitive brain--the planarian Dugesia japonica model.
abstract: A unique aspect of planarians is that they can regenerate a brain from somatic pluripotent stem cells called neoblasts, which have the ability to produce themselves (self-renew) and to give rise to all missing cell types during regeneration. Recent molecular studies have revealed that the planarian brain is composed of many distinct neuronal populations, which are evolutionarily and functionally conserved ones, and acts as an information-processing center to elicit distinct behavioral traits depending on a variety of signals arising from the external environment. How can planarians regenerate such a brain? On the basis of our recent findings, here we review the cellular and molecular mechanisms that regulate the stem cell dynamics involved in the brain regeneration of the planarian Dugesia japonica. Our findings suggest the possible value of in vivo planarian studies for guiding regenerative medicine to treat neurodegenerative diseases via interlinking stem cell biology and regeneration biology.
authors.affiliation: Department of Biophysics, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwake, Sakyo-ku, Kyoto, 606-8502, Japan. umesono@mdb.biophys.kyoto-u.ac.jp
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Umesono
authors.forename: Junichi
authors.initials: J
authors.lastname: Tasaki
authors.forename: Kaneyasu
authors.initials: K
authors.lastname: Nishimura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Inoue
authors.forename: Kiyokazu
authors.initials: K
authors.lastname: Agata
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology; D004777:Environment; D006706:Homeostasis; D009416:Nerve Regeneration / Q000502:physiology*; D010932:Planarians / Q000502:physiology*; D039904:Pluripotent Stem Cells / Q000502:physiology