title: Impact of nestin analysis in multiple myeloma.
abstract: Nestin, a marker of multipotent precursor cells, is an important dynamic structure; its polymerization/depolymerization influences intracellular signaling and participates in key cell processes such as proliferation, migration and cell survival. It is presumed that nestin plays a central role in carcinogenesis. It is suggested that nestin might be a suitable diagnostic and prognostic indicator of malignancy and a potential marker of cancer stem cells. Unexpectedly, nestin has been identified in mature CD138+CD38+ plasma cells (PC) of multiple myeloma patients (MM). Expression of nestin, a marker of stem/progenitor cells, in malignant PC, that are considered to be terminally differentiated, indicates that nestin might play a unique role in pathology of MM.
authors.affiliation: Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
authors.forename: H
authors.initials: H
authors.lastname: Sváchová
authors.forename: L
authors.initials: L
authors.lastname: Kovárová
authors.forename: J
authors.initials: J
authors.lastname: Stossová
authors.forename: A
authors.initials: A
authors.lastname: Potácová
authors.forename: L
authors.initials: L
authors.lastname: Pour
authors.forename: R
authors.initials: R
authors.lastname: Hájek
mesh_terms: D014408:Biomarkers, Tumor; D006801:Humans; D007381:Intermediate Filament Proteins / Q000032:analysis* / Q000502:physiology; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology; D009419:Nerve Tissue Proteins / Q000032:analysis* / Q000502:physiology; D064231:Nestin
chemical_list: D014408:Biomarkers, Tumor; D007381:Intermediate Filament Proteins; C577484:NES protein, human; D009419:Nerve Tissue Proteins; D064231:Nestin