title: A case of spinal and bulbar muscular atrophy with high-stage and high-Gleason Score prostate cancer responded to maximal androgen blockade therapy.
abstract: Spinal and bulbar muscular atrophy is a hereditary motor neuron disease  caused by the expansion of CAG triplets in the androgen receptor. Because the  length of CAG repeat is inversely related with androgen receptor function,  patients with a longer CAG repeat are expected to have a lower incidence of  prostate cancer. Here, we report an extremely rare case of high-stage prostate  cancer in a patient with spinal and bulbar muscular atrophy, which responded  to maximal androgen blockade therapy.
authors.affiliation: Keio University School of Medicine, Department of Urology, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. akiram@sc.itc.keio.ac.jp
authors.forename: Takeo
authors.initials: T
authors.lastname: Kosaka
authors.forename: Akira
authors.initials: A
authors.lastname: Miyajima
authors.forename: Eiji
authors.initials: E
authors.lastname: Kikuchi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Takahashi
authors.forename: Norihiro
authors.initials: N
authors.lastname: Suzuki
authors.forename: Mototsugu
authors.initials: M
authors.lastname: Oya
mesh_terms: D000726:Androgen Antagonists / Q000627:therapeutic use*; D055534:Bulbo-Spinal Atrophy, X-Linked; D005485:Flutamide / Q000627:therapeutic use*; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists; D006801:Humans; D016729:Leuprolide / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D011944:Receptors, Androgen / Q000235:genetics; D018911:Trinucleotide Repeats
chemical_list: C410798:AR protein, human; D000726:Androgen Antagonists; D011944:Receptors, Androgen; D007987:Gonadotropin-Releasing Hormone; D005485:Flutamide; D016729:Leuprolide