title: [Thalidomide-induced sensory neuropaty in patients with multiple myeloma].
abstract: Chemotherapy-induced sensory neuropathies differ in clinical picture. There is predominance of paresthesiae in some of them while in others pain or deep sensation failure can dominate.
  
  
  OBJECTIVE
  To perform the clinical and electrophysiological assessment of peripheral sensory nerves in patients with multiple myeloma (m.m.) treated with thalidomide. Special attention was directed to function of subtypes of sensory fibres which convey different modalities of sensation.
  
  
  METHODS
  Twenty seven m.m. patients and 30 controls were examined. Neurological examination together with allocation to different groups acc. to sNCI-CTC scale were performed. Standard sensory conduction velocity was measured in ulnar and sural nerves. Quantitative Sensory Testing (QST) was used to determine thermal detection thresholds.
  
  
  RESULTS
  All patients informed about subjective positive sensory symptoms and sensory deficit of symmetrical, distal pattern was found in them. Electroneurography revealed axonal and demyelinating abnormalities with dominance of axonal injury. Warm and heat-pain detection thresholds were elevated, while threshold for skin cooling was decreased both in palm and foot in m.m. patients in comparison with controls. There were no differences in the thresholds for cold-pain detection between examined groups.
  
  
  CONCLUSIONS
  Thalidomide-induced sensory neuropathy can appear shortly after the introduction of treatment. Patients with longer duration of treatment or with higher cumulative dose present higher degree of neuropathy acc. to the sCNI-CTC scale. Sensory deficit in thalidomide' neuropathy is associated with dysfunction in A delta and C caliber primary afferent fibres.
authors.affiliation: Akademia Medyczna we Wroctawiu, Katedra i Klinika Neurologii. mbilinsk@mp.pl
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Bilińska
authors.forename: Lidia
authors.initials: L
authors.lastname: Usnarska-Zubkiewicz
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Szymczyk
authors.forename: Leszek
authors.initials: L
authors.lastname: Noga
authors.forename: Stanislaw
authors.initials: S
authors.lastname: Potoczek
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Kuliczkowski
authors.forename: Ryszard
authors.initials: R
authors.lastname: Podemski
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004568:Electrodiagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy*; D009431:Neural Conduction; D009460:Neurologic Examination; D010292:Paresthesia / Q000139:chemically induced / Q000175:diagnosis; D012678:Sensation Disorders / Q000139:chemically induced* / Q000175:diagnosis*; D013792:Thalidomide / Q000009:adverse effects*
chemical_list: D013792:Thalidomide