title: Adoptive immunotherapy with virus-specific T cells.
abstract: Viral infections are still common causes of morbidity and mortality in immunosuppressed patients after allogeneic hematopoietic stem cell transplantation. Infections caused by virus such as cytomegalovirus, adenovirus and Epstein-Barr virus are well-known. In addition, several other viruses such as polyomavirus and human herpesvirus 6 have been recently reported to be causes of significant complications. As the delay in recovery of virus-specific cellular immune response after transplant is associated with viral reactivation and viral disease, adoptive immunotherapy to restore virus-specific cellular immunity is an attractive option. Recent clinical trials showed the safety and effectiveness of adoptive immunotherapy against viral diseases. In this review, we summarize the current status of adoptive immunotherapy against several viral diseases including cytomegalovirus, adenovirus, Epstein-Barr virus and polyomavirus.
authors.affiliation: Department of Internal Medicine II, Division of Hematology, University Hospital of Würzburg, Josef-Schneider-Straße 2, Würzburg, Germany.
authors.forename: Shigeo
authors.initials: S
authors.lastname: Fuji
authors.forename: Markus
authors.initials: M
authors.lastname: Kapp
authors.forename: Götz Ulrich
authors.initials: GU
authors.lastname: Grigoleit
authors.forename: Hermann
authors.initials: H
authors.lastname: Einsele
mesh_terms: D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D016867:Immunocompromised Host / Q000276:immunology; D016219:Immunotherapy, Adoptive / Q000379:methods*; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation*; D014184:Transplantation, Homologous; D014777:Virus Diseases / Q000276:immunology / Q000628:therapy / Q000821:virology