title: [Three children with Rasmussen encephalitis showing marked improvement in daily life activity following the functional hemispherectomy].
abstract: We investigated seizure, intelligence quotient (IQ), and neurological outcomes including the process of motor function recovery after functional right hemispherectomy in 3 children with Rasmussen's encephalitis (RE). Before the procedure, they were unable to walk, nor sit without support due to progressive worsening of left hemiplegia and relentless epilepsia partialis continua (EPC) of the left extremities, which were refractory to antiepileptic drug and immunological treatment. After functional right hemispherectomy, EPC completely disappeared, although complete left hemiplegia was sustained. However, they recovered up to being able to walk independently with assistance devices, and to have an ordinary life with family support within 1.5 to 5 months through rehabilitation. At the same time, the interictal EEG improved on the unaffected side of hemisphere, exhibiting a posterior alpha rhythm. Their IQ also improved, and they were able to attend school. Early functional hemispherectomy should be considered before patients with RE are left in a serious condition due to progressive worsening of hemiplegia and seizures refractory to the available treatment.
authors.affiliation: Department of Pediatrics, Tokyo Women's Medical University, Tokyo. mshioda@ped.twmu.ac.jp
authors.forename: Mutsuki
authors.initials: M
authors.lastname: Shioda
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Oguni
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ito
authors.forename: Taku
authors.initials: T
authors.lastname: Ochiai
authors.forename: Tomokatsu
authors.initials: T
authors.lastname: Hori
authors.forename: Ayako
authors.initials: A
authors.lastname: Muto
authors.forename: Satornu
authors.initials: S
authors.lastname: Takahashi
authors.forename: Akie
authors.initials: A
authors.lastname: Miyamoto
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Osaka
authors.forename: Makiko
authors.initials: M
authors.lastname: Osawa
mesh_terms: D000203:Activities of Daily Living; D000293:Adolescent; D002648:Child; D004569:Electroencephalography; D004660:Encephalitis / Q000503:physiopathology / Q000523:psychology / Q000534:rehabilitation* / Q000601:surgery*; D005260:Female; D038421:Hemispherectomy; D006801:Humans; D007360:Intelligence; D016896:Treatment Outcome