title: [Specificity and clinical features of erythrocytic allo-antibodies in hospitalized patients].
abstract: OBJECTIVE
  To evaluate the occurrence and clinical significance of red blood cell (RBC) allo-antibodies among hospitalized patients in China.
  
  
  METHODS
  The specificity and clinical features of RBC allo-antibodies of hospitalized patients at our hospital from August 2009 to January 2011 were retrospectively analyzed.
  
  
  RESULTS
  Sixty-four (0.17%) RBC allo-antibodies were detected from 37 548 hospitalized patients. The male-to-female ratio was 0.6:1 and the transfused: untransfused ratio 0.9:1. Two patients had experienced episodes of delayed hemolytic transfusion reaction (DHTR). Their antibody frequencies were as follows: anti-E 53.1% (34/64), anti-D 10.9% (7/64), anti-cE 3.1% (2/64), anti-c 1.6% (1/64), anti-M 14.1% (9/64), anti-Mi(a) 10.9% (7/64), anti-Le(a) 4.7% (3/64), anti-Di(a) 1.6% (1/64). Antibodies to Rh system were more frequent among transfused patients while antibodies to Lewis system had a male predominance (both P < 0.05).
  
  
  CONCLUSIONS
  As the most common and clinically significant RBC allo-antibodies, the antibodies to Rh blood group system, especially anti-E, anti-cE and anti-c, are the main cause of DHTR.
authors.affiliation: Department of Transfusion, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors.forename: Bo-ting
authors.initials: BT
authors.lastname: Wu
authors.forename: Ding-gen
authors.initials: DG
authors.lastname: Yao
authors.forename: Rui-ming
authors.initials: RM
authors.lastname: Rong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001789:Blood Group Antigens / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006801:Humans; D007297:Inpatients; D007518:Isoantibodies / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018029:Rho(D) Immune Globulin; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D001789:Blood Group Antigens; D007518:Isoantibodies; C061961:RHO(D) antibody; D018029:Rho(D) Immune Globulin