title: Colchicine in the management of mucous membrane pemphigoid.
abstract: Mucous membrane pemphigoid (MMP) usually runs a chronic and potentially devastating course. Its management requires long-term oral corticosteroids. Safe and effective adjuvant or steroid-sparing agents are needed. In this retrospective observational study with a follow-up extending to 16 years (mean: 4 years), 60% (9/15) of all patients with MMP were lesion-free under oral steroid therapy combined with a second immunosuppressant agent. Colchicine was the most effective, clearing from at least one individual mucosal site lesions in 67% (8/12) of patients. Colchicine may be suggested as a first-line corticosteroid-sparing regimen in the management of MMP.
authors.affiliation: State Hospital for Skin and Venereal Diseases, Thessaloniki, Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Chaidemenos
authors.forename: Theodoros
authors.initials: T
authors.lastname: Sidiropoulos
authors.forename: Paraskevoula
authors.initials: P
authors.lastname: Katsioula
authors.forename: Thalia
authors.initials: T
authors.lastname: Koussidou-Eremondi
mesh_terms: D000328:Adult; D000368:Aged; D003078:Colchicine / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010390:Pemphigoid, Benign Mucous Membrane / Q000188:drug therapy* / Q000473:pathology; D012189:Retrospective Studies; D016896:Treatment Outcome; D050257:Tubulin Modulators / Q000627:therapeutic use*
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D050257:Tubulin Modulators; D003078:Colchicine