title: Sesquiterpenoids from the endophytic fungus Trichoderma sp. PR-35 of Paeonia delavayi.
abstract: A new bisabolane-type sesquiterpene, trichoderic acid (1), and a new acorane-type sesquiterpene, 2β-hydroxytrichoacorenol (2), along with three known compounds, cyclonerodiol (3), cyclonerodiol oxide (4), and sorbicillin (5), were isolated from the culture broth of Trichoderma sp. PR-35, an endophytic fungus isolated from Paeonia delavayi. Their structures were elucidated on the basis of their IR, MS, and 1D- and 2D-NMR analyses. The antibacterial and antifungal activities of 1-5 towards various types of bacteria and fungi were tested. Most of the compounds showed moderate or weak antimicrobial activities in an agar-diffusion assay.
authors.affiliation: Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, P. R. China. shwu123@126.com
authors.forename: Shao-Hua
authors.initials: SH
authors.lastname: Wu
authors.forename: Li-Xing
authors.initials: LX
authors.lastname: Zhao
authors.forename: You-Wei
authors.initials: YW
authors.lastname: Chen
authors.forename: Rong
authors.initials: R
authors.lastname: Huang
authors.forename: Cui-Ping
authors.initials: CP
authors.lastname: Miao
authors.forename: Jiao
authors.initials: J
authors.lastname: Wang
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D029596:Paeonia / Q000382:microbiology*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D014242:Trichoderma / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: C569160:2beta-hydroxytrichoacorenol; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D012717:Sesquiterpenes; C569159:trichoderic acid