title: Identification and localization of S100A6 in human umbilical cord.
abstract: S100A6, a calcium-binding protein also known as calcyclin, was detected in human umbilical cord by immunoblotting. Immunohistochemical studies showed an intensive reaction for S100A6 in the walls of vessels and Wharton's jelly. In the latter, S100A6 was found not only in the myofibroblasts but also in the ECM (extracellular matrix) surrounding these cells. Affinity chromatography of S100A6 resin indicated that Wharton's jelly contains some proteins that could bind to S100A6. Thus these novel results show the presence of S100A6 in umbilical cord and suggest the involvement of this protein in intra- and extra-cellular signalling pathways in this tissue.
authors.affiliation: Nencki Institute of Experimental Biology, 3 Pasteur Street, 02093 Warsaw, Poland.
authors.forename: Ewelina
authors.initials: E
authors.lastname: Jurewicz
authors.forename: Irena
authors.initials: I
authors.lastname: Kasacka
authors.forename: Edward
authors.initials: E
authors.lastname: Bańkowski
authors.forename: Anna
authors.initials: A
authors.lastname: Filipek
mesh_terms: D018797:Cell Cycle Proteins / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007150:Immunohistochemistry; D011485:Protein Binding; D000075383:S100 Calcium Binding Protein A6; D009418:S100 Proteins / Q000032:analysis / Q000378:metabolism*; D015398:Signal Transduction; D014470:Umbilical Cord / Q000378:metabolism* / Q000473:pathology; D059631:Wharton Jelly / Q000378:metabolism
chemical_list: D018797:Cell Cycle Proteins; D000075383:S100 Calcium Binding Protein A6; D009418:S100 Proteins; C055351:S100A6 protein, human