title: Selection of reprogramming factors of induced pluripotent stem cells based on the protein interaction network and functional profiles.
abstract: Induced pluripotent stem cells have displayed great potential in disease investigation and drug development applications. However, selection of reprogramming factors in each cell type or disease state is both expensive and time consuming. To deal with this kind of situation, a fast computational framework was developed by optimize the reprogramming factors via the protein interaction network and gene functional profiles. It can be used to select reprogramming factors from millions of possibilities. It is anticipated that the novel approach will become a very useful tool for both basic research and drug development.
authors.affiliation: Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P R China.
authors.forename: Tao
authors.initials: T
authors.lastname: Huang
authors.forename: Yu-Dong
authors.initials: YD
authors.lastname: Cai
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.forename: Le-Le
authors.initials: LL
authors.lastname: Hu
authors.forename: Xiang-Yin
authors.initials: XY
authors.lastname: Kong
authors.forename: Yi-Xue
authors.initials: YX
authors.lastname: Li
authors.forename: Kuo-Chen
authors.initials: KC
authors.lastname: Chou
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D065150:Cellular Reprogramming / Q000502:physiology*; D016208:Databases, Factual; D020869:Gene Expression Profiling; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology / Q000378:metabolism*; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors / Q000737:chemistry / Q000235:genetics; D051379:Mice; D050814:Octamer Transcription Factor-3 / Q000737:chemistry / Q000235:genetics; D060066:Protein Interaction Maps / Q000502:physiology*; D016271:Proto-Oncogene Proteins c-myc / Q000737:chemistry / Q000235:genetics; D055748:SOXB1 Transcription Factors / Q000737:chemistry / Q000235:genetics; D049490:Systems Biology
chemical_list: D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors; C489428:Myc protein, mouse; D050814:Octamer Transcription Factor-3; C494174:Pou5f1 protein, mouse; D016271:Proto-Oncogene Proteins c-myc; D055748:SOXB1 Transcription Factors; C527783:Sox2 protein, mouse