title: Cardiovascular pharmacogenomics.
abstract: Patients vary in their responses to drug therapy, and some of that variability is genetically determined. This review outlines general approaches used to identify genetic variation that influences drug response. Examples from specific therapeutic areas are presented, such as cholesterol management, arrhythmias, heart failure, hypertension, warfarin anticoagulation, and antiplatelet agents. A brief view of potential pathways to implementation is presented.
authors.affiliation: Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232-0575, USA. dan.roden@vanderbilt.edu
authors.forename: Dan M
authors.initials: DM
authors.lastname: Roden
authors.forename: Julie A
authors.initials: JA
authors.lastname: Johnson
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Kimmel
authors.forename: Ronald M
authors.initials: RM
authors.lastname: Krauss
authors.forename: Marisa Wong
authors.initials: MW
authors.lastname: Medina
authors.forename: Alan
authors.initials: A
authors.lastname: Shuldiner
authors.forename: Russell A
authors.initials: RA
authors.lastname: Wilke
mesh_terms: D001692:Biological Transport / Q000235:genetics; D001711:Biotransformation / Q000235:genetics; D002317:Cardiovascular Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000235:genetics; D054796:Drug Dosage Calculations; D014644:Genetic Variation; D006801:Humans; D018579:Patient Selection; D010597:Pharmacogenetics; D057285:Precision Medicine; D018570:Risk Assessment; D016896:Treatment Outcome
chemical_list: D002317:Cardiovascular Agents