title: A plasmodesmata-localized protein mediates crosstalk between cell-to-cell communication and innate immunity in Arabidopsis.
abstract: Plasmodesmata (PD) are thought to play a fundamental role in almost every aspect of plant life, including normal growth, physiology, and developmental responses. However, how specific signaling pathways integrate PD-mediated cell-to-cell communication is not well understood. Here, we present experimental evidence showing that the Arabidopsis thaliana plasmodesmata-located protein 5 (PDLP5; also known as HOPW1-1-INDUCED GENE1) mediates crosstalk between PD regulation and salicylic acid-dependent defense responses. PDLP5 was found to localize at the central region of PD channels and associate with PD pit fields, acting as an inhibitor to PD trafficking, potentially through its capacity to modulate PD callose deposition. As a regulator of PD, PDLP5 was also essential for conferring enhanced innate immunity against bacterial pathogens in a salicylic acid-dependent manner. Based on these findings, a model is proposed illustrating that the regulation of PD closure mediated by PDLP5 constitutes a crucial part of coordinated control of cell-to-cell communication and defense signaling.
authors.affiliation: Department of Plant and Soil Sciences, University of Delaware, Newark, Delaware 19711, USA. lee@dbi.udel.edu
authors.forename: Jung-Youn
authors.initials: JY
authors.lastname: Lee
authors.forename: Xu
authors.initials: X
authors.lastname: Wang
authors.forename: Weier
authors.initials: W
authors.lastname: Cui
authors.forename: Ross
authors.initials: R
authors.lastname: Sager
authors.forename: Shannon
authors.initials: S
authors.lastname: Modla
authors.forename: Kirk
authors.initials: K
authors.lastname: Czymmek
authors.forename: Boris
authors.initials: B
authors.lastname: Zybaliov
authors.forename: Klaas
authors.initials: K
authors.lastname: van Wijk
authors.forename: Chong
authors.initials: C
authors.lastname: Zhang
authors.forename: Hua
authors.initials: H
authors.lastname: Lu
authors.forename: Venkatachalam
authors.initials: V
authors.lastname: Lakshmanan
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism*; D002450:Cell Communication; D016923:Cell Death; D009154:Mutation; D057865:Plant Immunity; D031425:Plasmodesmata / Q000378:metabolism*; D044224:Pseudomonas syringae / Q000472:pathogenicity; D020156:Salicylic Acid / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D029681:Arabidopsis Proteins; D020156:Salicylic Acid