title: [Functional improvement of injured retina following the adjuvant stem cell-based therapy. Preliminary report].
abstract: OBJECTIVE
  The purpose of this study was to appraise the functional response of damaged retina to the stem cell-based therapy in mice. The majority of disorders leading to the irreversible vision loss in the developed world is caused by retinal degeneration. Since, recent reports emphasized regenerative potential of bone marrow stem marrow stem/progenitor cells (SPCs), we investigated here the beneficial effect of intravenously administrated SPCs on regeneration of acutely injured retina.
  
  
  METHODS
  Selective chemical injury of murine retinas was induced by intravenous administration of sodium iodate (NalO3) in its toxic dose. Flash electroretinogram (ERG), was performed in different time points after infusion of bone marrow-derived and negative for linage antigens population of SPCs.
  
  
  RESULTS
  Stem cell-based therapy resulted in gradual increase of b-wave amplitude in ERG recordings starting from the 3rd day after NalO3 administration, what confirmed the improvement of retinal function in long-term observation.
  
  
  CONCLUSIONS
  Our preliminary findings revealed that the selected stem cell-based therapy employed in the adjuvant mode has been shown to be effective in supporting the retinal function recovery after acute retinal damage.
authors.affiliation: Z Katedry i Zakładu Histologii i Embriologii Pomorskiego Uniwersytetu Medycznego w Szczecinie. annam@sci.pam.szczecin.pl
authors.forename: Anna
authors.initials: A
authors.lastname: Machalińska
authors.forename: Wojciech
authors.initials: W
authors.lastname: Lubiński
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Penkala
authors.forename: Miłosz
authors.initials: M
authors.lastname: Kawa
authors.forename: Bartłomiej
authors.initials: B
authors.lastname: Baumert
authors.forename: Barbara
authors.initials: B
authors.lastname: Wiszniewska
authors.forename: Danuta
authors.initials: D
authors.lastname: Karczewicz
authors.forename: Bogusław
authors.initials: B
authors.lastname: Machaliński
mesh_terms: D000818:Animals; D016026:Bone Marrow Transplantation / Q000379:methods; D004195:Disease Models, Animal; D004596:Electroretinography / Q000379:methods; D018380:Hematopoietic Stem Cell Transplantation; D007452:Iodates; D051379:Mice; D008810:Mice, Inbred C57BL; D012038:Regeneration; D012160:Retina / Q000293:injuries* / Q000502:physiology / Q000601:surgery*; D012164:Retinal Diseases / Q000139:chemically induced / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D007452:Iodates; C032285:sodium iodate