title: Protective effects of amentoflavone on Lamin A-dependent UVB-induced nuclear aberration in normal human fibroblasts.
abstract: Lamin A-dependent nuclear aberration and DNA damage was found in premature aging disease or normally old individuals. In this study, UVB irradiation was used as a cellular senescence inducer, and it was found that Lamin A and phospho-H2AX protein was increased by UVB treatment on normal human fibroblast. Lamin A-dependent morphological nuclear defect was observed in UVB treated fibroblast. Amentoflavone, a well known biflavonoid, inhibited the increase of Lamin A or phospho-H2AX protein in dose dependent manner which was induced by UVB irradiation, and also protected nuclear aberration dramatically. These results indicated that amentoflavone is an anti-aging candidate for UVB related skin aging process.
authors.affiliation: Skin Research Institute, Amorepacific R&D Center, 314-1 Boradong, Giheung-gu, 446-729 Yongin, South Korea.
authors.forename: Nok-Hyun
authors.initials: NH
authors.lastname: Park
authors.forename: Chan-Woo
authors.initials: CW
authors.lastname: Lee
authors.forename: Ji-Hyun
authors.initials: JH
authors.lastname: Bae
authors.forename: Yong Joo
authors.initials: YJ
authors.lastname: Na
mesh_terms: D044946:Biflavonoids / Q000494:pharmacology*; D002467:Cell Nucleus / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D006801:Humans; D034904:Lamin Type A / Q000378:metabolism*; D014466:Ultraviolet Rays
chemical_list: D044946:Biflavonoids; D034904:Lamin Type A; C011164:amentoflavone