title: Replacement of the infected composite aortic root prosthesis.
abstract: BACKGROUND
  We sought to evaluate freedom from reinfection after surgery for infected aortic root replacement (ARR) and the impact of use of synthetic material at reoperation.
  
  
  METHODS
  Adult patients (aged more than 18 years) undergoing surgery for infected composite aortic root prosthesis at our institution were identified and their perioperative outcomes and late survival evaluated.
  
  
  RESULTS
  Between January 1, 1993, and December 31, 2009, 15 patients (male, 87%; mean [SD] age, 57 [16] years) underwent surgery. All but 1 patient (6.7%) underwent reconstruction with a homograft. Eight patients (53.3%) required synthetic material to complete the repair, including 4 patients who underwent hemiarch reconstruction. Ten patients (66.7%) had circulatory arrest (mean [SD] time, 23.3 [11.0] minutes) and 3 (20.0%) underwent concomitant coronary artery bypass grafting. The 30-day mortality rate was 13.3% (n = 2). Three patients (20.0%)-2 of whom had positive blood cultures in hospital after redo ARR-had reinfection, for which 2 underwent re-replacement of the aortic root. Survival was 86.7%, 65.0%, and 50.6%, and freedom from reinfection was 90.9%, 79.5%, and 79.5% at 3, 6, and 12 months, respectively. Freedom from reinfection was less for the patients who had positive blood cultures within 2 weeks of redo ARR (p < 0.03) and for patients who had multiple previous sternotomies (p = 0.006). Use of synthetic graft material had no adverse impact.
  
  
  CONCLUSIONS
  Infected ARR prostheses can be replaced with a homograft with favorable outcomes. Use of synthetic material to complete the repair does not adversely impact outcome.
authors.affiliation: Division of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Dipesh K
authors.initials: DK
authors.lastname: Shah
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Li
authors.forename: Soon J
authors.initials: SJ
authors.lastname: Park
authors.forename: Richard C
authors.initials: RC
authors.lastname: Daly
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Dearani
authors.forename: Hartzell V
authors.initials: HV
authors.lastname: Schaff
authors.forename: Thoralf M
authors.initials: TM
authors.lastname: Sundt
mesh_terms: D001424:Bacterial Infections / Q000209:etiology* / Q000601:surgery*; D006348:Cardiac Surgical Procedures / Q000379:methods; D005260:Female; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011474:Prosthesis Design; D016459:Prosthesis-Related Infections / Q000209:etiology* / Q000601:surgery*; D012189:Retrospective Studies