title: A new biodegradable adhesive for protection of intestinal anastomoses. Preliminary communication.
abstract: OBJECTIVE
  Anastomotic leaks continue to be a devastating complication for patients and surgeons worldwide. The few surgical adhesives available to date have not achieved the desired clinical results. The purpose of this experimental study was to determine if Pebisut® applied to intestinal suture lines provides increased resistance and protection during the critical days of healing.
  
  
  METHODS
  Intestinal lesions were caused in rats and dogs and a new biodegradable adhesive (Pebisut®) (patent granted in the European Union 07808494.4-1219, 01.12.2010, in Mexico P.C.T./MX/a/2009/001737, 16.02.2009, pending in the U.S.P.T.O. 60/762,136, 26.01.2006) was applied to compare the resistance of suture lines using bursting pressures and histologically.
  
  
  RESULTS
  Under acute and chronic conditions, Pebisut® strengthened and made the suture lines more resistant, while histologically penetrating and sealing them. The adhesive disappears within 2-3 weeks and is well tolerated by the intestinal tissues.
  
  
  CONCLUSIONS
  This biodegradable adhesive provides greater resistance, temporarily protects suture lines and may prevent anastomotic leaks.
authors.affiliation: Health Sciences Faculty, Anahuac University, Bosque de Magnolias No. 87, Mexico City, Mexico. cuetoj1@gmail.com
authors.forename: Jorge
authors.initials: J
authors.lastname: Cueto
authors.forename: Tomás
authors.initials: T
authors.lastname: Barrientos
authors.forename: Ernesto
authors.initials: E
authors.lastname: Rodríguez
authors.forename: Pamela
authors.initials: P
authors.lastname: Del Moral
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D001672:Biocompatible Materials; D004285:Dogs; D007422:Intestines / Q000601:surgery*; D051381:Rats; D017208:Rats, Wistar; D014014:Tissue Adhesives
chemical_list: D001672:Biocompatible Materials; D014014:Tissue Adhesives