title: [Studies on the level of proinflammatory cytokines IIL-1a, IL-1b, IL-6, TNF-a in pregnant women with acute pyelonephritis].
abstract: Proinflammatory cytokines (IL-1a, IL-1b, IL-6, TNF-a) are important mediators of acute inflammation. We studied the levels of those cytokines in pregnant women with acute pyelonephritis. MATERIAL AND METHODS. We studied 30 women with clinical and microbiological evidence of acute pyelonephritis and 30 healthy controls Urinary cytokine levels were measured using an ELISA test.
  
  
  RESULTS
  The mean urinary cytokine levels of pregnant women with acute pyelonephritis were higher compared with controls. We found evidence for higher clinical microbiological activity in women with acute pyelonephritis compared to controls. CONCLUSIONS. The urinary levels of proinflamatory cytokines can be used as reliable biomarkers for acute pyelonephritis in pregnant women.
authors.forename: E
authors.initials: E
authors.lastname: Dimitrakova
authors.forename: I
authors.initials: I
authors.lastname: Kostov
mesh_terms: D000208:Acute Disease; D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000652:urine*; D053582:Interleukin-1alpha / Q000652:urine; D053583:Interleukin-1beta / Q000652:urine; D015850:Interleukin-6 / Q000652:urine*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000382:microbiology / Q000652:urine*; D011704:Pyelonephritis / Q000150:complications* / Q000382:microbiology / Q000652:urine*; D014409:Tumor Necrosis Factor-alpha / Q000652:urine*; D055815:Young Adult
chemical_list: D007375:Interleukin-1; D053582:Interleukin-1alpha; D053583:Interleukin-1beta; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha