title: Ovarian function in adolescents with McCune-Albright syndrome.
abstract: OBJECTIVE
  To evaluate ovarian function, especially ovulation rate, in adolescents with McCune-Albright syndrome (MAS) and a history of peripheral precocious puberty.
  
  
  METHODS
  Prospective cross-sectional study.
  
  
  METHODS
  Academic center.
  
  
  METHODS
  A total of eight adolescents with MAS were compared with 15 healthy adolescents matched by age, Tanner stage and body mass index.
  
  
  METHODS
  We determined basal gonadotropins, sex steroids, sex hormone binding globulin, anti-Müllerian hormone, glucose and insulin. A leuprolide acetate test was performed to measure luteinizing hormone (LH) and follicle stimulating hormone (FSH) (at 0 and 3 h), and 17B-estradiol, testosterone and 17-OH-progesterone (at 0 and 24 h). Salivary progesterone levels were used to assess ovulation during the 13th, 18th, 23rd and 28th days of each menstrual cycle for three to five consecutive cycles, and one pelvic ultrasound was performed during the follicular phase.
  
  
  METHODS
  Ovulation rate in adolescents with MAS.
  
  
  RESULTS
  The proportion of ovulatory cycles was 52.6% in controls compared with 35.7% in patients with MAS.
  
  
  CONCLUSIONS
  The adolescent girls with MAS appear to have a lower ovulatory rate compared with controls.
authors.affiliation: Institute of Maternal and Child Research, University of Chile, Hospital San Borja Arriaran, Santiago, Chile.
authors.forename: Karina
authors.initials: K
authors.lastname: Sotomayor
authors.forename: German
authors.initials: G
authors.lastname: Iñiguez
authors.forename: Francisca
authors.initials: F
authors.lastname: Ugarte
authors.forename: Claudio
authors.initials: C
authors.lastname: Villarroel
authors.forename: Patricia
authors.initials: P
authors.lastname: López
authors.forename: Alejandra
authors.initials: A
authors.lastname: Avila
authors.forename: Ethel
authors.initials: E
authors.lastname: Codner
authors.forename: Fernando
authors.initials: F
authors.lastname: Cassorla
mesh_terms: D000293:Adolescent; D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D005359:Fibrous Dysplasia, Polyostotic / Q000097:blood / Q000473:pathology / Q000503:physiopathology*; D043373:Follicle Stimulating Hormone, Human / Q000097:blood; D005498:Follicular Phase; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists; D006801:Humans; D017588:Hyperandrogenism / Q000209:etiology; D016729:Leuprolide; D007986:Luteinizing Hormone / Q000097:blood; D010053:Ovary / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D010060:Ovulation / Q000187:drug effects; D011446:Prospective Studies; D011629:Puberty, Precocious / Q000209:etiology; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D043373:Follicle Stimulating Hormone, Human; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D016729:Leuprolide