title: Diagnosis of hepatic hemangioma by parametric imaging using sonazoid-enhanced US.
abstract: OBJECTIVE
  Comparison of Parametric Imaging (PI) using Sonazoid-enhanced ultrasonography (US) and microflow imaging (MFI) to determine the possibility of hepatic hemangioma diagnosis using PI.
  
  
  METHODS
  Twenty-two hepatic hemangioma nodules (mean±SD diameter: 31.6±19.1mm) undergoing Sonazoid-enhanced US between February 2008 and March 2009. After Sonazoid-enhanced US, COMMUNE ultrasonographic image analysis software was used for analysis of tumor imaging dynamics in the vascular phase using PI and MFI. In PI, 0s was set as the time contrast agent reached the tumor. Imaging within the tumor after 0s was color-coded according to time, and the images were displayed in color. In MFI, 0s was set as the time contrast agent reached the tumor. The path of microbubbles as it flowed through blood vessels was superimposed on the original B-mode images. Three trained physicians used these methods to analyze tumor imaging dynamics.
  
  
  RESULTS
  All physicians concluded all cases were hepatic hemangioma regardless of method used. However, compared to MFI, PI allowed determination of more detailed blood flow dynamics in high-flow hepatic hemangioma, where blood flow speed was faster than in normal hepatic hemangioma.
  
  
  CONCLUSIONS
  It is possible to diagnose hepatic hemangioma using PI using sonazoid-enhanced US.
authors.affiliation: Toho University, Omori Medical Center, Tokyo, Japan. noriwakiu@yahoo.co.jp
authors.forename: Noritaka
authors.initials: N
authors.lastname: Wakui
authors.forename: Ryuji
authors.initials: R
authors.lastname: Takayama
authors.forename: Naohisa
authors.initials: N
authors.lastname: Kamiyama
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Takahashi
authors.forename: Kazue
authors.initials: K
authors.lastname: Shiozawa
authors.forename: Hidenari
authors.initials: H
authors.lastname: Nagai
authors.forename: Manabu
authors.initials: M
authors.lastname: Watanabe
authors.forename: Koji
authors.initials: K
authors.lastname: Ishii
authors.forename: Kazunari
authors.initials: K
authors.lastname: Iida
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Igarashi
authors.forename: Yasukiyo
authors.initials: Y
authors.lastname: Sumino
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D005290:Ferric Compounds; D006391:Hemangioma / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D007501:Iron; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010087:Oxides; D014463:Ultrasonography
chemical_list: D003287:Contrast Media; D005290:Ferric Compounds; D010087:Oxides; C069727:Sonazoid; D007501:Iron