title: Parvovirus B19 presenting with persistent pancytopenia in a patient of T-ALL post induction chemotherapy diagnosed on bone marrow examination.
abstract: Manifestations of parvovirus B19 vary even in the normal host from asymptomatic or subclinical infection to a spectrum of illness with symptoms during viremic and immune complex mediated stage of disease. We report the morphological findings of parvovirus B19 infection (confirmed on serology) in a patient of T-acute lymphoblastic lymphoma (T-ALL) who underwent induction phase of chemotherapy (MCP 842 protocol). Persistent pancytopenia in the bone marrow aspirate with mild increase in blasts was thought to be due to failure to achieve marrow remission. However, giant pronormoblasts with prominent intranuclear inclusions confirmed on trephine biopsy led to the suspicion of parvovirus B19 infection which was later confirmed on serology. This case is presented to report the rarely seen classical morphological feature of parvovirus infection on bone marrow examination which was incidentally the first investigation to diagnose the viremic phase of the infection, indicating that a high index of suspicion needs to be kept in mind while examining bone marrows of susceptible patients.
authors.affiliation: Department of Pathology, Tata Memorial Hospital, Parel, Mumbai, India.
authors.forename: Vijaya S
authors.initials: VS
authors.lastname: Gadage
authors.forename: Seethalakshmi
authors.initials: S
authors.lastname: Viswanathan
authors.forename: Sehgal
authors.initials: S
authors.lastname: Kunal
authors.forename: P G
authors.initials: PG
authors.lastname: Subramanian
authors.forename: Sumeet
authors.initials: S
authors.lastname: Gujral
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage; D001853:Bone Marrow / Q000473:pathology; D001856:Bone Marrow Examination; D006651:Histocytochemistry; D006801:Humans; D060828:Induction Chemotherapy / Q000379:methods*; D008297:Male; D008853:Microscopy; D010198:Pancytopenia / Q000175:diagnosis* / Q000209:etiology; D010322:Parvoviridae Infections / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D016732:Parvovirus B19, Human / Q000302:isolation & purification* / Q000472:pathogenicity; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents