title: Alzheimer's disease pathologic cascades: who comes first, what drives what.
abstract: This review discusses known and speculated relationships between Alzheimer's disease (AD) biochemical, molecular, and histologic phenomena. In the AD brain, various pathologies including neuritic plaques, neurofibrillary tangles, synaptic loss, oxidative stress, cell cycle re-entry, and mitochondrial changes have all been described. In an attempt to explain what exactly goes wrong in the AD brain various investigators have proposed different heuristic and hierarchical schemes. It is important to accurately define the AD pathology hierarchy because treatments targeting the true apex of its pathologic cascade arguably have the best chance of preventing, mitigating, or even curing this disease.
authors.affiliation: Department of Neurology, University of Kansas Medical Center, Kansas City, KS 66160, USA. rswerdlow@kumc.edu
authors.forename: Russell H
authors.initials: RH
authors.lastname: Swerdlow
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology* / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D001921:Brain / Q000473:pathology*; D002453:Cell Cycle; D018450:Disease Progression; D006801:Humans; D028361:Mitochondrial Diseases / Q000209:etiology; D016874:Neurofibrillary Tangles / Q000473:pathology; D018384:Oxidative Stress; D016875:tau Proteins / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D016875:tau Proteins