title: [Eosinophilic colitis caused by clozapine].
abstract: BACKGROUND
  Clozapine is an antipsychotic agent used when patients experience excessive extrapyramidal side effects from other antipsychotic agents or for therapy resistant schizophrenia. However, clozapine is also known for its serious adverse effects e.g. granulocytopenia and agranulocytosis.
  
  
  METHODS
  A 40-year-old male with known schizophrenia, presented with severe diarrhea and eosinophilia in the peripheral blood examination result, arising 2 weeks after starting clozapine. Histopathological examination demonstrated an eosinophilic colitis. After the patient discontinued clozapine, the symptoms disappeared completely.
  
  
  CONCLUSIONS
  Eosinophilic colitis is a rare adverse effect of clozapine. It is only possible to diagnose this using endoscopy and biopsy, so that the complaint is often not recognised. The exact pathophysiology underlying this eosinophilic colitis is not known.
authors.affiliation: Sint Lucas Andreas Ziekenhuis, afd. Psychiatrie, Amsterdam.
authors.forename: A W
authors.initials: AW
authors.lastname: de Raad
authors.forename: N C
authors.initials: NC
authors.lastname: Siegersma
authors.forename: P C
authors.initials: PC
authors.lastname: Clahsen
authors.forename: C
authors.initials: C
authors.lastname: Hagestein-de Bruijn
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003024:Clozapine / Q000009:adverse effects* / Q000627:therapeutic use; D003092:Colitis / Q000139:chemically induced*; D004802:Eosinophilia / Q000139:chemically induced*; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000188:drug therapy
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine