title: Protein assembly directed by synthetic molecular recognition motifs.
abstract: Tris-functionalized cyanuric acid (TCA) and melamine (TM) selectively recognize each other in aqueous solution with 1 : 1 stoichiometry. We have coupled biotin to TCA and TM to allow pseudo-tetrahedral display of TCA and TM on streptavidin through biotin-ligand binding. Synthetic cyanuric acid/melamine recognition is found to drive selective protein-protein assembly.
authors.affiliation: Department of Chemistry, The Ohio State University, Columbus, USA.
authors.forename: Mingming
authors.initials: M
authors.lastname: Ma
authors.forename: Dennis
authors.initials: D
authors.lastname: Bong
mesh_terms: D001710:Biotin / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D011485:Protein Binding; D020836:Protein Structure, Quaternary; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D019809:Streptavidin / Q000737:chemistry*; D014227:Triazines / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D008024:Ligands; D011506:Proteins; D014227:Triazines; D001710:Biotin; D019809:Streptavidin; C004632:cyanuric acid; C011907:melamine