title: Dual colored mesoporous silica nanoparticles with pH activable rhodamine-lactam for ratiometric sensing of lysosomal acidity.
abstract: Alteration of lysosome acidity has been implicated in many biological events ranging from apoptosis to cancer metastasis, etc. Mesoporous silica nanoparticles doped with acid activable rhodamine-lactam and fluorescein isothiocyanate (FITC) were developed for ratiometric sensing of lysosomal pH changes in live cells with flow cytometry.
authors.affiliation: Department of Chemical Biology, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005, China.
authors.forename: Shuqi
authors.initials: S
authors.lastname: Wu
authors.forename: Zhu
authors.initials: Z
authors.lastname: Li
authors.forename: Jiahuai
authors.initials: J
authors.lastname: Han
authors.forename: Shoufa
authors.initials: S
authors.lastname: Han
mesh_terms: D000818:Animals; D002460:Cell Line; D002623:Chemistry Techniques, Analytical / Q000295:instrumentation*; D003116:Color; D016650:Fluorescein-5-isothiocyanate / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007769:Lactams / Q000737:chemistry*; D008247:Lysosomes / Q000737:chemistry*; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D016062:Porosity; D012235:Rhodamines / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D007769:Lactams; D012235:Rhodamines; D012822:Silicon Dioxide; D016650:Fluorescein-5-isothiocyanate