title: A systematic study of chiral homoprolinols and their derivatives in the catalysis of enantioselective addition of diethylzinc to aldehydes.
abstract: Homoprolinol analogs, a class of optically active γ-amino alcohols, were examined systematically in the enantioselective addition reactions of diethylzinc to aldehydes. By comparison of the results catalyzed by these γ-amino alcohols with those by the β-amino alcohols based on pyrrolidine architecture reported in the literature references, we have observed that the γ-amino alcohols are superior to the corresponding β-amino alcohols when the nitrogen and the oxygen are unsubstituted. Among the homoprolinols we tested, gave the best results (45-88% yields, 44-81% ee) in the addition reactions. To the best of our knowledge, has been noticed as one of the most efficient γ-amino alcohol catalysts based on pyrrolidine framework.
authors.affiliation: School of Chemistry and Chemical Engineering, Southwest University, Beibei, Chongqing 400715, P. R. China; Department of Chemistry and Chemical Engineering, Sichuan University of Arts and Science, Dazhou 635000, P. R. China.
authors.forename: Chang-Lu
authors.initials: CL
authors.lastname: Liu
authors.forename: Chang-Yong
authors.initials: CY
authors.lastname: Wei
authors.forename: Shi-Wen
authors.initials: SW
authors.lastname: Wang
authors.forename: Yun-Gui
authors.initials: YG
authors.lastname: Peng