title: EUCAST technical note on posaconazole.
abstract: The European Committee on Antimicrobial Susceptibility Testing-Subcommittee on Antifungal Susceptibility Testing (EUCAST-AFST) has determined breakpoints for posaconazole for Candida spp. This Technical Note is based on the EUCAST posaconazole rationale document (available on the EUCAST website: http://www.eucast.org). Species-specific breakpoints for C. albicans, C. parapsilosis and C. tropicalis are S: MIC ≤0.06 mg/L, R: MIC >0.06 mg/L. There are insufficient data to set breakpoints for C. glabrata and C. krusei as well as non-species-related breakpoints. The breakpoints are based upon pharmacokinetic data, epidemiological cut-off values and clinical experience. Breakpoints will be reviewed regularly.
authors.affiliation: Unit of Mycology, Department of Microbiological Surveillance and Research, Statens Serum Institute, Copenhagen, Denmark. maiken@arendrup.dk
authors.forename: M C
authors.initials: MC
authors.lastname: Arendrup
authors.forename: M
authors.initials: M
authors.lastname: Cuenca-Estrella
authors.forename: J P
authors.initials: JP
authors.lastname: Donnelly
authors.forename: W
authors.initials: W
authors.lastname: Hope
authors.forename: C
authors.initials: C
authors.lastname: Lass-Flörl
authors.forename: J-L
authors.initials: JL
authors.lastname: Rodriguez-Tudela
mesh_terms: D000935:Antifungal Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D014230:Triazoles / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole