title: Study of surfactant-skin interactions by skin impedance measurements.
abstract: The stratum corneum (SC) plays a very critical physiological role as skin barrier in regulating water loss through the skin and protects the body from a wide range of physical and chemical exogenous insults. Surfactant-containing formulations can induce skin damage and irritation owing to surfactant absorption and penetration. It is generally accepted that reduction in skin barrier properties occurs only after surfactants have penetrated/permeated into the skin barrier. To mitigate the harshness of surfactant-based cleansing products, penetration/permeation of surfactants should be reduced. Skin impedance measurements have been taken in vitro on porcine skin using vertical Franz diffusion cells to investigate the impact of surfactants, temperature and pH on skin barrier integrity. These skin impedance results demonstrate excellent correlation with other published methods for assessing skin damage and irritation from different surfactant chemistry, concentration, pH, time of exposure and temperature. This study demonstrates that skin impedance can be utilized as a routine approach to screen surfactant-containing formulations for their propensity to compromise the skin barrier and hence likely lead to skin irritation.
authors.affiliation: Global R&D, International Specialty Products, Wayne, NJ 07470, USA. glu@ispcorp.com
authors.forename: Guojin
authors.initials: G
authors.lastname: Lu
authors.forename: David J
authors.initials: DJ
authors.lastname: Moore
mesh_terms: D000818:Animals; D017097:Electric Impedance; D004817:Epidermis / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D012867:Skin / Q000187:drug effects* / Q000378:metabolism*; D012869:Skin Absorption / Q000187:drug effects*; D012967:Sodium Dodecyl Sulfate / Q000493:pharmacokinetics / Q000494:pharmacology*; D013501:Surface-Active Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D013552:Swine
chemical_list: D013501:Surface-Active Agents; D012967:Sodium Dodecyl Sulfate