title: Absence of changes in cortical thickness in patients with migraine.
abstract: OBJECTIVE
  Previous studies have reported gray matter alterations in patients with migraine, particularly thinning of the cingulate gyrus, and thickening of the somatosensory cortex (SSC) and visual motion processing areas (V3A/MT+). We attempted to replicate these findings in a larger patient population.
  
  
  METHODS
  Brain anatomy was collected with 3T MRI. Surface-based morphometry was used to segment each brain volume, reconstruct and inflate the cortical sheet, and estimate gray matter thickness.
  
  
  RESULTS
  Eighty-four age and sex-matched participants (28 migraine with aura, 28 migraine without aura, and 28 controls) were studied. No significant differences in somatosensory, cingulate gyrus, or V3A/MT+ cortical thickness were found between the groups, including analysis of specific subregions previously reported to be affected. Whole brain analysis found no regions of differential gray matter thickness between groups. A highly significant inverse correlation between age and whole brain and regional cortical thickness was identified. Power analyses indicate that even a small difference (∼0.07 to 0.14 mm) in cortical thickness could have been detected between groups given the sample size.
  
  
  CONCLUSIONS
  Using highly sensitive surface-based morphometry, no differences in cortical thickness between patients with migraine and controls could be identified.
authors.affiliation: University of Pennsylvania, USA.
authors.forename: Ritobrato
authors.initials: R
authors.lastname: Datta
authors.forename: John A
authors.initials: JA
authors.lastname: Detre
authors.forename: Geoffrey K
authors.initials: GK
authors.lastname: Aguirre
authors.forename: Brett
authors.initials: B
authors.lastname: Cucchiara
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000033:anatomy & histology* / Q000502:physiology*; D005260:Female; D006179:Gyrus Cinguli / Q000033:anatomy & histology / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020325:Migraine with Aura / Q000473:pathology* / Q000503:physiopathology; D020326:Migraine without Aura / Q000473:pathology* / Q000503:physiopathology; D009039:Motion Perception / Q000502:physiology; D013003:Somatosensory Cortex / Q000033:anatomy & histology / Q000502:physiology; D014793:Visual Cortex / Q000033:anatomy & histology / Q000502:physiology; D014796:Visual Perception / Q000502:physiology