title: [Intracellular transport proteins: classification, structure and function of kinesins].
abstract: Correct cell functioning, division and morphogenesis rely on efficient intracellular transport. Apart from dyneins and myosins, kinesins are the main proteins responsible for intracellular movement. Kinesins are a large, diverse group of motor proteins, which based on phylogenetic similarity were classified into fourteen families. Among these families, due to the location of their motor domains, three groups have been characterized: N-, C- and M-kinesin. As molecular motors, kinesins transport various molecules and vesicles mainly towards the microtubule plus end (from the cell body) participating in anterograde transport, although there are also kinesins involved in retrograde transport (C-kinesins). Kinesins are also involved in spindle formation, chromosome segregation, and spermatogenesis. Because of their great importance for the correct functioning of cells, mutations in kinesin coding genes may lead to such neurodegenerative diseases as dominant hereditary spastic paraplegia or Charcot-Marie-Tooth disease.
authors.affiliation: Katedra i Zakład Biochemii, Warszawski Uniwersytet Medyczny.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Chudy
authors.forename: Beata
authors.initials: B
authors.lastname: Gajewska
authors.forename: Marzena
authors.initials: M
authors.lastname: Gutowicz
authors.forename: Anna
authors.initials: A
authors.lastname: Barańczyk-Kuźma
mesh_terms: D002352:Carrier Proteins / Q000378:metabolism*; D006801:Humans; D016547:Kinesins / Q000145:classification* / Q000378:metabolism; D008954:Models, Biological; D021381:Protein Transport / Q000502:physiology
chemical_list: D002352:Carrier Proteins; D016547:Kinesins