title: Diagnostic efficacy of gadoxetic acid-enhanced MRI for hepatocellular carcinoma and dysplastic nodule.
abstract: OBJECTIVE
  To evaluate the relationship between the signal intensity of hepatobiliary phase images on gadoxetic acid-enhanced magnetic resonance imaging (MRI) and histological grade.
  
  
  METHODS
  Fifty-nine patients with 82 hepatocellular lesions were evaluated retrospectively. Hepatobiliary phase images on gadoxetic acid-enhanced MRI were classified into 3 groups: low, iso or high. Angiography-assisted computed tomography (CT) findings were also classified into 3 groups: CT during arterial portography, and CT hepatic arteriography: A: iso, iso or low; B: slightly low, iso or low; and C: low, high. We correlated angiography-assisted CT, hepatobiliary phase findings during gadoxetic acid-enhanced MRI and histological grades. Furthermore, correlations between MRI findings and histological grade for each hemodynamic pattern were performed. Correlations among radiological and pathological findings were statistically evaluated using the chi-square test and Fisher' s exact test.
  
  
  RESULTS
  There was a significant correlation between histological grade and hemodynamic pattern (P < 0.05). There was a significant correlation between histological grade and signal intensity in the hepatobiliary phase (P < 0.05) in group A lesions. There was no significant correlation between histological grade and signal intensity in the hepatobiliary phase in group B or C lesions (P > 0.05).
  
  
  CONCLUSIONS
  Signal intensity in the hepatobiliary phase correlated with histological grade in the lesions that maintained portal blood flow, but did not correlate in lesions that showed decreased or defective portal blood flow.
authors.affiliation: Department of Radiology, Tokyo Medical University, 160-0023 Tokyo, Japan. saito-k@tokyo-med.ac.jp
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Saito
authors.forename: Fuminori
authors.initials: F
authors.lastname: Moriyasu
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Sugimoto
authors.forename: Ryota
authors.initials: R
authors.lastname: Nishio
authors.forename: Toru
authors.initials: T
authors.lastname: Saguchi
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Nagao
authors.forename: Junichi
authors.initials: J
authors.lastname: Taira
authors.forename: Soichi
authors.initials: S
authors.lastname: Akata
authors.forename: Koichi
authors.initials: K
authors.lastname: Tokuuye
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000473:pathology*; D005260:Female; D019786:Gadolinium DTPA; D006439:Hemodynamics; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA