title: Gastroprotective activity of epitaondiol and sargaol.
abstract: The effects of epitaondiol (1) and sargaol (2), isolated from the brown alga Stypopodium flabelliforme on HCl/ethanol-induced gastric lesions in mice were evaluated and compared with that of lansoprazole. Epitaondiol and sargaol (6.25 - 50 mg/kg) dose-dependently inhibited the appearance of gastric lesions in mice, displaying similar values to lansoprazole at 20 mg/kg. Both epitaondiol and sargaol showed gastroprotective activity with ED50 values of 40 mg/kg and 35 mg/kg, respectively. The results suggest that epitaondiol and sargaol protect the gastric mucosa in the HCl/EtOH model in mice.
authors.affiliation: Departamento de Química, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile. areche@uchile.cl
authors.forename: Carlos
authors.initials: C
authors.lastname: Areche
authors.forename: Aurelio
authors.initials: A
authors.lastname: San-Martín
authors.forename: Juana
authors.initials: J
authors.lastname: Rovirosa
authors.forename: Beatriz
authors.initials: B
authors.lastname: Sepúlveda
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000494:pharmacology; D000818:Animals; D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000494:pharmacology*; D000431:Ethanol / Q000633:toxicity*; D006851:Hydrochloric Acid / Q000633:toxicity*; D064747:Lansoprazole; D051379:Mice; D015394:Molecular Structure; D000459:Phaeophyceae / Q000737:chemistry; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000517:prevention & control; D013729:Terpenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D013729:Terpenes; C561788:sargaol; D064747:Lansoprazole; D000431:Ethanol; C094446:epitaondiol; D006851:Hydrochloric Acid