title: Antifungal activity of Ocimum sanctum Linn. (Lamiaceae) on clinically isolated dermatophytic fungi.
abstract: OBJECTIVE
  To assess antifungal activity of Ocimum sanctum leaves against dermatophytic fungi.
  
  
  METHODS
  Antifungal activity of Ocimum sanctum leaves was measured by 38 A NCCLS method. Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of various extracts and fractions of Ocimum sanctum leaves were also determined.
  
  
  RESULTS
  Ocimum sanctum leaves possessed antifungal activity against clinically isolated dermatophytes at the concentration of 200 μg/mL. MIC and MFC were high with water fraction (200 μg/mL) against dermatophytic fungi used.
  
  
  CONCLUSIONS
  Ocimum sanctum has antifungal activity, and the leaf extracts may be a useful source for dermatophytic infections.
authors.affiliation: Department of Chemistry and Biosciences, SASTRA University, Srinivasa Ramanujan Centre, Kumbakonam, Tamil Nadu, India.
authors.forename: S
authors.initials: S
authors.lastname: Balakumar
authors.forename: S
authors.initials: S
authors.lastname: Rajan
authors.forename: T
authors.initials: T
authors.lastname: Thirunalasundari
authors.forename: S
authors.initials: S
authors.lastname: Jeeva
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D004821:Epidermophyton / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008825:Miconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D031339:Ocimum / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry; D012997:Solvents; D014005:Tinea / Q000188:drug therapy* / Q000382:microbiology; D014867:Water
chemical_list: D000935:Antifungal Agents; D010936:Plant Extracts; D012997:Solvents; D014867:Water; D008825:Miconazole