title: Efficacy and safety of intraoperative radiotherapy in breast cancer: a systematic review.
abstract: The objective of this study is to assess the efficacy and safety of intraoperative radiotherapy (IORT) for early breast cancer through a systematic review. Fifteen studies met the inclusion criteria. Most studies assessed the combined treatment with IORT (10-24Gy) and external beam radiotherapy (EBRT) (45-50Gy) on early stage breast cancer (T(0-2)). Local control was over 95% for 1 and 4years of follow-up and the 5-year overall survival was 99%. The TARGIT-A study found a similar survival comparing IORT with standard treatment. The incidence of acute and chronic complications was scarce. IORT is well tolerated by patients and acute and late toxicities are low. There are no differences in survival for IORT treated patients versus standard treatment.
authors.affiliation: Galician Agency for Health Technology Assessment, Galician Department of Health, Spain. alberto.ruano@usc.es
authors.forename: A
authors.initials: A
authors.lastname: Ruano-Ravina
authors.forename: P
authors.initials: P
authors.lastname: Cantero-Muñoz
authors.forename: A
authors.initials: A
authors.lastname: Eraso Urién
mesh_terms: D001943:Breast Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007430:Intraoperative Care / Q000379:methods*; D011878:Radiotherapy / Q000379:methods*; D016019:Survival Analysis; D016896:Treatment Outcome