title: Screening questionnaires for parkinsonism: a systematic review.
abstract: Parkinson's disease (PD) is a common, treatable movement disorder that often remains undiagnosed despite clinically manifest symptoms. Screening for parkinsonism could lead to improved detection and earlier treatment, and facilitate research studies of PD prevalence. In order to determine the feasibility of screening, this study evaluated the validity of previously developed screening questionnaires. We systematically searched online databases PubMed and EMBASE for English-language studies published between 1980 and 2009. In each database a "Parkinson(s) disease" or "parkinsonism" term was combined with a screening term ("screening instrument," "screening questionnaire," "screen" or "prevalence survey") and a validity term ("validation," "sensitivity" and "specificity"). Included studies reported the psychometric properties of at least one self-report questionnaire for parkinsonism. Twenty-seven studies met the inclusion criteria. From these studies, 9 screening questionnaires were identified. Sensitivity and specificity estimates varied widely. Sensitivity estimates were as high as 100% when questionnaires were tested among previously diagnosed PD patients and included a high number of parkinsonism specific items, but were as low as 48% when tested among early cases in a community-based sample. Specificity estimates were lower, ranging from 22 to 100%. An older sample, presence of multiple co-morbid conditions and lower literacy led to lower specificity estimates. Higher specificity estimates were seen when the screening questionnaires were administered by a physician. Screening questionnaires can detect symptomatic parkinsonism. However, the performance of these questionnaires varied based on the individual items, study sample, and method of administration. The performance of screening questionnaires in the detection of early or mild parkinsonism was modest.
authors.affiliation: Department of Neurology, University of Pennsylvania, PA, USA. dahodwan@mail.med.upenn.edu
authors.forename: Nabila
authors.initials: N
authors.lastname: Dahodwala
authors.forename: Andrew
authors.initials: A
authors.lastname: Siderowf
authors.forename: Mona
authors.initials: M
authors.lastname: Baumgarten
authors.forename: Aaron
authors.initials: A
authors.lastname: Abrams
authors.forename: Jason
authors.initials: J
authors.lastname: Karlawish
mesh_terms: D006801:Humans; D008403:Mass Screening / Q000379:methods; D010300:Parkinson Disease / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires