title: Mesenchymal stromal cells: a promising cell source for the treatment of inflammatory cardiomyopathy.
abstract: Inflammatory cardiomyopathy is associated with a diffuse inflammation in the heart accompanied with cardiac fibrosis, cardiomyocyte apoptosis, and reduced capillary density. On the other hand, mesenchymal stromal cells (MSCs) have immunomodulatory, anti-fibrotic, anti-apoptotic, and pro-angiogenic features, making them attractive candidates for the treatment of inflammatory cardiomyopathy. The potential of MSC application for the treatment of myocarditis is supported by their beneficial effects in experimental models of acute and chronic inflammatory cardiomopathy. This review summarizes the cardioprotective features of MSCs and describes how MSCs are primed by the inflammatory environment to exert their protective effects. In view of clinical translation, searching for the optimal source of MSC and delivery route, allowing efficient and non-invasive cell application, the differences between MSCs of distinct origin and between diverse routes of application are outlined.
authors.affiliation: Department of Cardiology & Pneumology, Charité-University Medicine, Berlin Campus, Benjamin Franklin Hindenburgdamm 30, 12200 Berlin. carsten.tschoepe@charite.de
authors.forename: C
authors.initials: C
authors.lastname: Tschöpe
authors.forename: K
authors.initials: K
authors.lastname: Miteva
authors.forename: H-P
authors.initials: HP
authors.lastname: Schultheiss
authors.forename: S Van
authors.initials: SV
authors.lastname: Linthout
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000235:genetics / Q000276:immunology / Q000502:physiology; D002986:Clinical Trials as Topic; D016207:Cytokines / Q000235:genetics / Q000276:immunology; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000276:immunology; D009205:Myocarditis / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D019076:Transgenes; D016896:Treatment Outcome
chemical_list: D016207:Cytokines