title: Role of positron emission tomography in management of sinonasal neoplasms--a single institution's experience.
abstract: OBJECTIVE
  The objective of the study is to examine the utility of positron emission tomography (PET) for staging and restaging after treatment of paranasal sinus carcinomas.
  
  
  METHODS
  Retrospective data review was done.
  
  
  METHODS
  Patients selected underwent PET for sinonasal neoplasms from 2003 to 2008 at a tertiary care referral center.
  
  
  RESULTS
  Seventy-seven scans were reviewed from 31 patients. The pathologies included olfactory neuroblastoma (n = 9), squamous cell carcinoma (n = 6), sinonasal undifferentiated carcinoma (n = 6), sinonasal melanoma (n = 6), and minor salivary gland carcinomas (n = 4). The positive predictive value of studies performed for restaging at the primary, neck, and distant sites were 56%, 54%, and 63%; negative predictive values were 93%, 100%, and 98%, respectively. During restaging, 32% of patients were accurately upstaged secondary to neck or distant site involvement.
  
  
  CONCLUSIONS
  Positron emission tomography serves as a useful adjunct to conventional imaging in the management of sinonasal malignancies. Negative studies are effective in predicting absence of disease as seen in the consistently high-negative predictive values. Positive studies need to be viewed cautiously given the high rate of false-positive studies. When viewed in conjunction with clinical examination, endoscopic assessment, and focused biopsies, they may effectively result in a more accurate assessment of the extent of disease.
authors.affiliation: Head and Neck Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
authors.forename: Eric D
authors.initials: ED
authors.lastname: Lamarre
authors.forename: Pete S
authors.initials: PS
authors.lastname: Batra
authors.forename: Robert R
authors.initials: RR
authors.lastname: Lorenz
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Citardi
authors.forename: David J
authors.initials: DJ
authors.lastname: Adelstein
authors.forename: Shyam M
authors.initials: SM
authors.lastname: Srinivas
authors.forename: Joseph
authors.initials: J
authors.lastname: Scharpf
mesh_terms: D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009333:Neck; D009367:Neoplasm Staging / Q000379:methods; D010255:Paranasal Sinus Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary / Q000628:therapy; D049268:Positron-Emission Tomography / Q000379:methods*; D015203:Reproducibility of Results; D012189:Retrospective Studies