title: Terpenoid and phenolic metabolites from the fungus xylaria sp. associated with termite nests.
abstract: Three new sesquiterpene acids, xylaric acids A-C (1-3, resp.), and a new tetralone (=3,4-dihydronaphthalen-1(2H)-one) derivative, 4, along with nine known compounds, xylaric acid D (5), hydroheptelidic acid (6), gliocladic acid (7), chlorine heptelidic acid (8), trichoderonic acid A (9), 16-(α-D-mannopyranosyloxy)isopimar-7-en-19-oic acid (10), 16-(α-D-glucopyranosyloxy)isopimar-7-en-19-oic acid (11), 5-carboxymellein (12), and naphthalen-1,8-diol 1-O-α-D-glucopyranoside (13) have been isolated from the solid culture of the ascomycete fungus Xylaria sp. associated with termite nest. The structures of these compounds were elucidated primarily by NMR experiments. The absolute configurations of compounds 1-3 and 5-9 were determined by combination of X-ray data and CD spectral analysis. The absolute configuration of 4 was assigned by Snatzke's method. Compounds 8 and 11 showed slight cytotoxicities against two cell lines A549 and SGC7901.
authors.affiliation: Key Lab of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences, No.8 Beiertiao, Zhongguancun, Haidian District, Beijing 100090, P. R. China.
authors.forename: Sha
authors.initials: S
authors.lastname: Yan
authors.forename: Saifei
authors.initials: S
authors.lastname: Li
authors.forename: Wen
authors.initials: W
authors.lastname: Wu
authors.forename: Feng
authors.initials: F
authors.lastname: Zhao
authors.forename: Li
authors.initials: L
authors.lastname: Bao
authors.forename: Rong
authors.initials: R
authors.lastname: Ding
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
authors.forename: Hua-An
authors.initials: HA
authors.lastname: Wen
authors.forename: Fuhang
authors.initials: F
authors.lastname: Song
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Liu
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D006801:Humans; D020049:Isoptera / Q000382:microbiology / Q000502:physiology*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010636:Phenols / Q000302:isolation & purification / Q000378:metabolism* / Q000633:toxicity; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D013098:Xylariales / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D010636:Phenols; D013729:Terpenes