title: Plaque radiotherapy treatment with ruthenium-106 for iris malignant melanoma.
abstract: OBJECTIVE
  To report the results of ruthenium-106 plaque radiotherapy for iris malignant melanoma.
  
  
  METHODS
  A retrospective study of 15 patients with pure iris melanoma treated with ruthenium-106 plaque radiotherapy from June 1998 to June 2006. The main outcome measures were tumour control and ocular complications.
  
  
  RESULTS
  Of the 15 patients, 8 had biopsy-proven melanoma (6 incisional and 2 excisional biopsies). In the remaining seven patients enlargement of the lesion was documented. The median follow-up was 96 months (ranging from 14 months to 12 years). Common radiation-related complications included cataract in 9 (60%) patients, dry eyes in 3 (20%) patients and elevated intraocular pressure in 4 (27%) patients. Vision was preserved in 80% of patients. Local tumour control was obtained in all patients.
  
  
  CONCLUSIONS
  Ruthenium-106 plaque radiotherapy is an effective treatment for primary malignant iris melanoma, resulting in excellent local control with preservation of vision. Main complications included cataract, dry eyes, and glaucoma.
authors.affiliation: Department of Ophthalmology, St Bartholomew's Hospital and Moorfields Eye Hospital, London, UK. maria.tsimpida@bartsandthelondon.nhs.uk
authors.forename: M
authors.initials: M
authors.lastname: Tsimpida
authors.forename: J
authors.initials: J
authors.lastname: Hungerford
authors.forename: A
authors.initials: A
authors.lastname: Arora
authors.forename: V
authors.initials: V
authors.lastname: Cohen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007429:Intraocular Pressure / Q000528:radiation effects; D015811:Iris Neoplasms / Q000532:radiotherapy*; D008297:Male; D008545:Melanoma / Q000532:radiotherapy*; D008875:Middle Aged; D012189:Retrospective Studies; D012429:Ruthenium Radioisotopes / Q000627:therapeutic use*
chemical_list: D012429:Ruthenium Radioisotopes