title: Pseudo-five-component reaction between 3-formylchromones, meldrum's acid, isocyanides and primary arylamines: diversity-oriented synthesis of novel chromone-containing peptidomimetics.
abstract: An efficient and practical method has been developed for the diversity-oriented synthesis of chromone-containing tripeptides via pseudo-five-component reaction between 3-formylchromones, Meldrum's acid, isocyanides and primary aromatic amines for the generation of a wide range of structurally interesting and pharmacologically significant compounds at ambient temperature. It is worth mentioning that in the course of this reaction, five new bonds (two C-C bonds, two C-N bonds and one C═O bond) are formed. In the present reaction three amide bonds are newly formed.
authors.affiliation: Petrochemical Department, Iran Polymer and Petrochemical Institute, Tehran, Iran. m.teimouri@ippi.ac.ir
authors.forename: Mohammad Bagher
authors.initials: MB
authors.lastname: Teimouri
authors.forename: Peyman
authors.initials: P
authors.lastname: Akbari-Moghaddam
authors.forename: Golara
authors.initials: G
authors.lastname: Golbaghi
mesh_terms: D000577:Amides / Q000737:chemistry; D000588:Amines / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D002867:Chromones / Q000737:chemistry*; D003486:Cyanides / Q000737:chemistry*; D004146:Dioxanes / Q000737:chemistry*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D008956:Models, Chemical; D009584:Nitrogen / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry; D057786:Peptidomimetics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013696:Temperature
chemical_list: D000577:Amides; D000588:Amines; D002867:Chromones; D003486:Cyanides; D004146:Dioxanes; D006841:Hydrocarbons, Aromatic; D057786:Peptidomimetics; C502480:formylchromone; D002244:Carbon; C076489:Meldrum's acid; D009584:Nitrogen; D010100:Oxygen