title: Polymorphism of the FcγRIIIa gene and post-treatment apical periodontitis.
abstract: BACKGROUND
  Polymorphisms of genes encoding leukocyte surface receptors for the constant region of immunoglobulin G (FcγR) might influence the host response to infection and consequently affect the outcome of the endodontic treatment. This study investigated the association of FcγRIIIa gene (FcγRIIIA) polymorphism with post-treatment apical periodontitis in Brazilian subjects.
  
  
  METHODS
  The study population consisted of 26 patients with post-treatment apical periodontitis and 43 subjects with root canal-treated teeth exhibiting healthy/healing periradicular tissues (controls). All teeth had apical periodontitis lesions at the time of treatment, which was completed at least 1 year previously. Saliva was collected from the participants; DNA was extracted and used for FcγRIIIA genotyping.
  
  
  RESULTS
  No significant associations were found between any specific genotype of FcγRIIIA (P = .63) or allele (P = .76) and post-treatment apical periodontitis. Overall, the most prevalent allele in the study population was FcγRIIIA-F158 (68.8%). The genotype V/F was the most common among the population, occurring in 50.7% of the subjects.
  
  
  CONCLUSIONS
  Data from the present study suggest that polymorphism in the FcγRIIIa does not influence the patient's response to endodontic treatment of teeth with apical periodontitis.
authors.affiliation: Department of Endodontics and Molecular Microbiology Laboratory, Estácio de Sá University, Rio de Janeiro, Brazil. jf_siqueira@yahoo.com
authors.forename: José F
authors.initials: JF
authors.lastname: Siqueira
authors.forename: Isabela N
authors.initials: IN
authors.lastname: Rôças
authors.forename: José C
authors.initials: JC
authors.lastname: Provenzano
authors.forename: Bianca P S
authors.initials: BP
authors.lastname: Guilherme
mesh_terms: D000328:Adult; D000483:Alleles; D001938:Brazil; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002908:Chronic Disease; D019232:Dental Restoration Failure; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D060885:Multiplex Polymerase Chain Reaction; D010485:Periapical Periodontitis / Q000235:genetics* / Q000276:immunology* / Q000628:therapy; D011110:Polymorphism, Genetic; D017452:Receptors, IgG / Q000235:genetics*; D012390:Root Canal Therapy; D012463:Saliva / Q000737:chemistry; D017211:Treatment Failure
chemical_list: C496124:FCGR3A protein, human; D017452:Receptors, IgG