title: Acidic triazoles as soluble guanylate cyclase stimulators.
abstract: A series of acidic triazoles with activity as soluble guanylate cyclase stimulators is described. Incorporation of the CF(3) triazole improved the overall physicochemical and drug-like properties of the molecule and is exemplified by compound 25.
authors.affiliation: Worldwide Medicinal Chemistry, Pfizer, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK. lee.roberts@pfizer.com
authors.forename: Lee R
authors.initials: LR
authors.lastname: Roberts
authors.forename: Paul A
authors.initials: PA
authors.lastname: Bradley
authors.forename: Mark E
authors.initials: ME
authors.lastname: Bunnage
authors.forename: Katherine S
authors.initials: KS
authors.lastname: England
authors.forename: David
authors.initials: D
authors.lastname: Fairman
authors.forename: Yvette M
authors.initials: YM
authors.lastname: Fobian
authors.forename: David N A
authors.initials: DN
authors.lastname: Fox
authors.forename: Geoff E
authors.initials: GE
authors.lastname: Gymer
authors.forename: Steven E
authors.initials: SE
authors.lastname: Heasley
authors.forename: Jerome
authors.initials: J
authors.lastname: Molette
authors.forename: Graham L
authors.initials: GL
authors.lastname: Smith
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Schmidt
authors.forename: Michael A
authors.initials: MA
authors.lastname: Tones
authors.forename: Kevin N
authors.initials: KN
authors.lastname: Dack
mesh_terms: D000143:Acids / Q000737:chemistry*; D020536:Enzyme Activators / Q000494:pharmacology*; D006162:Guanylate Cyclase / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D000071756:Soluble Guanylyl Cyclase; D014230:Triazoles / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000143:Acids; D020536:Enzyme Activators; D018160:Receptors, Cytoplasmic and Nuclear; D014230:Triazoles; D006162:Guanylate Cyclase; D000071756:Soluble Guanylyl Cyclase