title: [Clinical efficacy of desmopressin in the treatment of mild hemophilia A in children].
abstract: OBJECTIVE
  To study the effects of desmopressin (DDAVP) on coagulation factor Ⅷ (FⅧ) and activated partial thromboplastin time (APTT) in children with mild hemophilia A.
  
  
  METHODS
  Eighteen children with mild hemophilia A were enrolled. DDAVP (0.3 μg/kg•d) was injected intravenously for 5 days. Plasma FⅧ levels and APTT were measured before and after DDAVP treatment.
  
  
  RESULTS
  In 16 of 18 children with mild hemophilia A, the bleeding symptoms, including the articular or musclar hematoma, were significantly alleviated as a result of DDAVP treatment. The plasma FⅧ levels increased significantly to (27±4)% and APTT was shortened to (66±10)s 60 minutes after the first dose of DDAVP treatment. The plasma FⅧ remained at the levels of 25%-30% during 3-4 days of DDAVP treatment. Five days after DDAVP treatment, the plasma FⅧ levels decreased [(21±3)%], and APTT was prolonged when compared with 1-4 days of DDAVP treatment.
  
  
  CONCLUSIONS
  DDAVP treatment can increase plasma FⅧ levels and shorten APTT in children with mild hemophilia A. DDAVP is effective in the treatment of mild hemophilia A. The duration of DDAVP therapy for mild hemophilia A is recommended as 3 to 4 days.
authors.affiliation: Department of Pediatrics, First Affiliated Hospital of Medical College, Zhengzhou University, Zhengzhou, China.
authors.forename: Song-Ting
authors.initials: ST
authors.lastname: Bai
authors.forename: Jie
authors.initials: J
authors.lastname: Lu
authors.forename: Guang-Yao
authors.initials: GY
authors.lastname: Sheng
authors.forename: Song-Tao
authors.initials: ST
authors.lastname: Xu
authors.forename: Lei
authors.initials: L
authors.lastname: Xie
authors.forename: Shao
authors.initials: S
authors.lastname: Peng
mesh_terms: D002648:Child; D002675:Child, Preschool; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use*; D005169:Factor VIII / Q000032:analysis; D006467:Hemophilia A / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D008297:Male; D010314:Partial Thromboplastin Time
chemical_list: D005169:Factor VIII; D003894:Deamino Arginine Vasopressin