title: Effect of Curculigo orchioides on hyperglycemia-induced oligospermia and sexual dysfunction in male rats.
abstract: Sustained hyperglycemia is considered as a major cause of sexual and erectile dysfunction in human population. Curculigo orchioides (CO) is considered as a sexual tonic in Ayurvedic system of medicine with potent antioxidant and adaptogenic properties. The aqueous extract of the herb was evaluated for its effectiveness against streptozotocin-induced hyperglycemic stress and subsequent sexual dysfunction due to hyperglycemia in male rats. Six groups with eight male rats in each group were used for this study and the study was carried out for 28 days. The body and organ weights of the animals were recorded. Behavioral analysis of rats was undertaken to observe the effect on mount, ejaculation and intromission (latencies and frequencies) and hesitation time. Blood glucose and serum testosterone levels were determined 28 days past treatment with CO at 100 and 200 mg kg(-1) doses. Glibenclamide and sildenafil citrate were used as positive controls. This deleterious effect of sustained hyperglycemia and associated stress was prominently ameliorated in animals treated with aqueous extract of CO. CO treatment was helpful in ameliorating the damage caused by sustained hyperglycemia evidenced in the principle parameters viz. male sexual behavior, sperm count, penile erection index and seminal fructose content Antioxidant and anabolic activities of the extract under investigation could be a major attribute in preserving the sexual functions in hyperglycemic male rats. The study validates the use of CO in traditional medicine for curing diabetes-induced sexual dysfunction and compromised sexual potency.
authors.affiliation: Central institute for Laboratory Medicine, Charite, Campus Benjamin Franklin, Hindenburgdamm, Berlin, Germany. mayankthakur25@gmail.com
authors.forename: M
authors.initials: M
authors.lastname: Thakur
authors.forename: N S
authors.initials: NS
authors.lastname: Chauhan
authors.forename: V
authors.initials: V
authors.lastname: Sharma
authors.forename: V K
authors.initials: VK
authors.lastname: Dixit
authors.forename: S
authors.initials: S
authors.lastname: Bhargava
mesh_terms: D000818:Animals; D000975:Antioxidants; D031408:Curculigo; D003921:Diabetes Mellitus, Experimental / Q000150:complications* / Q000188:drug therapy; D005632:Fructose / Q000032:analysis; D006943:Hyperglycemia / Q000150:complications* / Q000188:drug therapy; D008297:Male; D009845:Oligospermia / Q000209:etiology / Q000517:prevention & control*; D010410:Penile Erection; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012661:Semen / Q000737:chemistry; D012726:Sexual Behavior, Animal; D012735:Sexual Dysfunction, Physiological / Q000209:etiology / Q000517:prevention & control*; D013076:Sperm Count
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D005632:Fructose