title: Farnesol-induced cell death in the filamentous fungus Aspergillus nidulans.
abstract: FOH (farnesol), a non-sterol isoprenoid produced by dephosphorylation of farnesyl pyrophosphate, has been shown to inhibit proliferation and induce apoptosis. We have been using Aspergillus nidulans and FOH as a model system and cell death stimulus, respectively, aiming to understand by which means filamentous fungi are driven towards cell death. Here, we review some of our findings about FOH-induced cell death in A. nidulans.
authors.affiliation: Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Taísa Magnani
authors.initials: TM
authors.lastname: Dinamarco
authors.forename: Maria Helena S
authors.initials: MH
authors.lastname: Goldman
authors.forename: Gustavo Henrique
authors.initials: GH
authors.lastname: Goldman
mesh_terms: D000818:Animals; D001233:Aspergillus nidulans / Q000166:cytology / Q000187:drug effects* / Q000502:physiology*; D016923:Cell Death / Q000187:drug effects* / Q000502:physiology; D005204:Farnesol / Q000494:pharmacology*; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D056811:Unfolded Protein Response / Q000502:physiology
chemical_list: D005656:Fungal Proteins; D005204:Farnesol