title: Dynamic multicomponent hemiaminal assembly.
abstract: A simple approach to generating in situ metal-templated tris-(2-picolyl)amine-like multicomponent assemblies with potential applications in molecular recognition and sensing is reported. The assembly is based on the reversible covalent association between di-(2-picolyl)amine and aldehydes. Zinc ion is best for inducing assembly among the metal salts investigated, whereas 2-picolinaldehyde is the best among the heterocyclic aldehydes studied. Although an equilibrium constant of 6.6×10(3) M(-1) was measured for the assembly formed by 2-picolinaldehdye, di-(2-picolyl)amine, and zinc triflate, the equilibrium constants for other systems are in the 10(2) M(-1) range. X-ray structural analysis revealed that zinc adopts trigonal-bipyramidal geometry within the assembled ligand. The diversity and equilibrium of the assemblies are readily altered by simply changing concentrations, varying components, or adding counteranions.
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, TX 78712, USA.
authors.forename: Lei
authors.initials: L
authors.lastname: You
authors.forename: S Reid
authors.initials: SR
authors.lastname: Long
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Lynch
authors.forename: Eric V
authors.initials: EV
authors.lastname: Anslyn
mesh_terms: D000588:Amines / Q000737:chemistry*; D000838:Anions / Q000737:chemistry; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D010848:Picolinic Acids / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
chemical_list: C501847:2,2'-dipicolylamine; D000588:Amines; D000838:Anions; D010848:Picolinic Acids; D011725:Pyridines; C522921:picolinaldehyde; D015032:Zinc