title: Gender differences in language and motor-related fibers in a population of healthy preterm neonates at term-equivalent age: a diffusion tensor and probabilistic tractography study.
abstract: OBJECTIVE
  Sex differences in white matter structure are controversial. In this MR imaging study, we aimed to investigate possible sex differences in language and motor-related tracts in healthy preterm neonates by using DTI and probabilistic tractography.
  
  
  METHODS
  Thirty-eight preterm neonates (19 boys and 19 girls, age-matched), healthy at term-equivalent age and at 12 months were included. TBV was measured individually. Probabilistic tractography provided tract volumes, relative tract volumes (volume normalized to TBV), FA, MD, and λ(⊥) in the SLF, in the TRs, and in the CSTs. Data were compared by using independent t tests, and Bonferroni corrections were performed to adjust for multiple comparisons.
  
  
  RESULTS
  We showed that healthy preterm boys had larger TBV than girls. However, girls had statistically significantly larger relative tract volumes than boys bilaterally in the parieto-temporal SLF, and in the left CST. Moreover, in the left parieto-temporal SLF, a trend toward lower MD and λ(⊥) was observed in females.
  
  
  CONCLUSIONS
  Structural sex differences were found in preterm neonates at term-equivalent age in both sides of the parieto-temporal SLF and in the left CST. Further studies are necessary to investigate whether these structural differences are related to later sex differences in language skills and handedness or to the effect of prematurity.
authors.affiliation: Department of Radiology, ULB-Hopital Erasme, Brussels, Belgium. yanliu@ulb.ac.be
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: T
authors.initials: T
authors.lastname: Metens
authors.forename: J
authors.initials: J
authors.lastname: Absil
authors.forename: V
authors.initials: V
authors.lastname: De Maertelaer
authors.forename: D
authors.initials: D
authors.lastname: Balériaux
authors.forename: P
authors.initials: P
authors.lastname: David
authors.forename: V
authors.initials: V
authors.lastname: Denolin
authors.forename: B
authors.initials: B
authors.lastname: Van Overmeire
authors.forename: F
authors.initials: F
authors.lastname: Avni
authors.forename: P
authors.initials: P
authors.lastname: Van Bogaert
authors.forename: A
authors.initials: A
authors.lastname: Aeby
mesh_terms: D038524:Diffusion Magnetic Resonance Imaging; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007802:Language; D008297:Male; D009044:Motor Cortex / Q000166:cytology*; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure*; D009434:Neural Pathways / Q000166:cytology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012737:Sex Factors