title: Ubiquitination of transporters at the forefront of plant nutrition.
abstract: In plants, the tight regulation of plasma membrane transporters is essential to maintain nutrient homeostasis. The mechanisms controlling the abundance of transporters, and other integral plasma membrane proteins, now come to light. Ubiquitination appears as a major signal initiating cargo endocytosis and sorting into multivesicular bodies prior to degradation in the vacuole. We have indeed demonstrated that the root iron transporter IRT1 is subjected to ubiquitin-dependent trafficking in root epidermal cells. This control is crucial to keep IRT1 levels at the cell surface low and to cope with the toxicity associated with other readily available metal substrates of IRT1. Our work combined with recent report on the BOR1 boron transporter establishes ubiquitination as a conserved mechanism of plasma membrane protein trafficking in plants, and highlights its importance for plant nutrition.
authors.affiliation: Biochimie et Physiologie Moléculaire des Plantes, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5004, Institut de Biologie Intégrative des Plantes, Montpellier, France.
authors.forename: Enric
authors.initials: E
authors.lastname: Zelazny
authors.forename: Marie
authors.initials: M
authors.lastname: Barberon
authors.forename: Catherine
authors.initials: C
authors.lastname: Curie
authors.forename: Grégory
authors.initials: G
authors.lastname: Vert
mesh_terms: D002462:Cell Membrane / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000378:metabolism*; D008954:Models, Biological; D009747:Nutritional Physiological Phenomena; D010944:Plants / Q000378:metabolism*; D021381:Protein Transport; D025801:Ubiquitin / Q000378:metabolism; D054875:Ubiquitination
chemical_list: D026901:Membrane Transport Proteins; D025801:Ubiquitin