title: Meeting the physical activity guidelines and survival after breast cancer: findings from the after breast cancer pooling project.
abstract: The 2008 Physical Activity (PA) Guidelines recommend engaging in at least 2.5 h (10 MET-hours/week) of moderate intensity PA per week (defined as 4 METs) to reduce risk of morbidity and mortality. This analysis was conducted to investigate whether this recommendation can be extended to breast cancer survivors. Data from four studies of breast cancer survivors measuring recreational PA from semi-quantitative questionnaires a median of 23 months post-diagnosis (interquartile range 18-32 months) were pooled in the After Breast Cancer Pooling Project (n = 13,302). Delayed entry Cox proportional hazards models were applied in data analysis with adjustment for age, post-diagnosis body mass index, race/ethnicity, menopausal status, TNM stage, cancer treatment, and smoking history. Engaging in at least 10 MET-hours/week of PA was associated with a 27% reduction in all-cause mortality (n = 1,468 events, Hazard Ratio (HR) = 0.73, 95% CI, 0.66-0.82) and a 25% reduction in breast cancer mortality (n = 971 events, HR = 0.75, 95% CI 0.65-0.85) compared with women who did not meet the PA Guidelines (<10 MET-hours/week). Risk of breast cancer recurrence (n = 1,421 events) was not associated with meeting the PA Guidelines (HR = 0.96, 95% CI, 0.86-1.06). These data suggest that adhering to the PA guidelines may be an important intervention target for reducing mortality among breast cancer survivors.
authors.affiliation: Fred Hutchinson Cancer Research Center, 1000 Fairview Ave N M3-A410, Seattle, WA 98109, USA. jbeasley@whi.org
authors.forename: Jeannette M
authors.initials: JM
authors.lastname: Beasley
authors.forename: Marilyn L
authors.initials: ML
authors.lastname: Kwan
authors.forename: Wendy Y
authors.initials: WY
authors.lastname: Chen
authors.forename: Erin K
authors.initials: EK
authors.lastname: Weltzien
authors.forename: Candyce H
authors.initials: CH
authors.lastname: Kroenke
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Nechuta
authors.forename: Lisa
authors.initials: L
authors.lastname: Cadmus-Bertram
authors.forename: Ruth E
authors.initials: RE
authors.lastname: Patterson
authors.forename: Barbara
authors.initials: B
authors.lastname: Sternfeld
authors.forename: Xiao-Ou
authors.initials: XO
authors.lastname: Shu
authors.forename: John P
authors.initials: JP
authors.lastname: Pierce
authors.forename: Bette J
authors.initials: BJ
authors.lastname: Caan
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology / Q000401:mortality* / Q000534:rehabilitation*; D015444:Exercise; D005260:Female; D019983:Guideline Adherence; D006801:Humans; D008875:Middle Aged; D009043:Motor Activity; D010349:Patient Compliance; D012008:Recurrence; D012307:Risk Factors; D011795:Surveys and Questionnaires