title: On the origin of the triplet puzzle of homologies in receptor heteromers: immunoglobulin triplets in different types of receptors.
abstract: Based on our theory, we have discovered main triplets of amino acid residues in the GABAB1 receptor and several other neural receptors which seem to come from immunoglobulin chains and appear also as homologies in receptor heteromers. The obtained results strengthen our hypothesis that these triplets may "guide-and-clasp" receptor-receptor interactions playing a role, e.g., in neuroinflammation disorders.
authors.affiliation: St. Petersburg Institute for Informatics and Automation, Russian Academy of Sciences, Saint Petersburg, Russia. sasha_tar@hotmail.com
authors.forename: Alexander O
authors.initials: AO
authors.lastname: Tarakanov
authors.forename: Kjell G
authors.initials: KG
authors.lastname: Fuxe
authors.forename: Dasiel O
authors.initials: DO
authors.lastname: Borroto-Escuela
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000939:Epitopes / Q000737:chemistry / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000737:chemistry*; D007143:Immunoglobulin Heavy Chains / Q000737:chemistry; D007147:Immunoglobulin Light Chains / Q000737:chemistry; D007075:Immunoglobulin M / Q000737:chemistry*; D008956:Models, Chemical; D020078:Neurogenic Inflammation / Q000276:immunology / Q000378:metabolism; D015213:Neuroimmunomodulation / Q000235:genetics / Q000276:immunology; D054730:Protein Interaction Domains and Motifs / Q000276:immunology; D055503:Protein Multimerization / Q000276:immunology; D018080:Receptors, GABA-B / Q000737:chemistry; D017386:Sequence Homology, Amino Acid
chemical_list: D000939:Epitopes; D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D007075:Immunoglobulin M; D018080:Receptors, GABA-B