title: SAPHO: What radiologists should know.
abstract: SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) is an umbrella acronym for inflammatory clinical conditions whose common denominator is aseptic osteoarticular involvement with characteristic skin lesions. It involves all ages, can involve any skeletal site, and has variable imaging appearances depending on the stage/age of the lesion and imaging method. It mimics important differentials including infection and neoplasia. Awareness of the imaging features, especially in the spine, facilitates early diagnosis, prevents repeated biopsies, and avoids unnecessary surgery, while initiating appropriate treatment.
authors.affiliation: Radiology Department, Robert Jones and Agnes Hunt Orthopaedic and District Hospitals NHS Trust, Gobowen, Oswestry, Shropshire, UK.
authors.forename: R
authors.initials: R
authors.lastname: Depasquale
authors.forename: N
authors.initials: N
authors.lastname: Kumar
authors.forename: R K
authors.initials: RK
authors.lastname: Lalam
authors.forename: B J
authors.initials: BJ
authors.lastname: Tins
authors.forename: P N M
authors.initials: PN
authors.lastname: Tyrrell
authors.forename: J
authors.initials: J
authors.lastname: Singh
authors.forename: V N
authors.initials: VN
authors.lastname: Cassar-Pullicino
mesh_terms: D020083:Acquired Hyperostosis Syndrome / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D000328:Adult; D002648:Child; D003937:Diagnosis, Differential; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D064847:Multimodal Imaging / Q000379:methods; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D012871:Skin Diseases / Q000209:etiology; D013122:Spinal Diseases / Q000150:complications / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed / Q000379:methods; D051598:Whole Body Imaging / Q000379:methods
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18