title: Design, synthesis and insight into the structure-activity relationship of 1,3-disubstituted indazoles as novel HIF-1 inhibitors.
abstract: Design, synthesis and insight into the structure-activity relationship (SAR) of 1,3-disubstituted indazoles as novel HIF-1 inhibitors are described. In particular, the substituted furan moiety on indazole skeleton as well as its substitution pattern turns out crucial for the high HIF-1 inhibition.
authors.affiliation: College of Pharmacy, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
authors.forename: Hongchan
authors.initials: H
authors.lastname: An
authors.forename: Nam-Jung
authors.initials: NJ
authors.lastname: Kim
authors.forename: Jong-Wha
authors.initials: JW
authors.lastname: Jung
authors.forename: Hannah
authors.initials: H
authors.lastname: Jang
authors.forename: Jong-Wan
authors.initials: JW
authors.lastname: Park
authors.forename: Young-Ger
authors.initials: YG
authors.lastname: Suh
mesh_terms: D015153:Blotting, Western; D002460:Cell Line; D015195:Drug Design; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000037:antagonists & inhibitors*; D007191:Indazoles / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D007191:Indazoles