title: [Recent anti-aging studies on caloric restriction and resveratrol].
abstract: Seventy-five years after its initial report, lifespan prolongation by caloric restriction (CR) has been confirmed in many animal species. Gathered evidences suggest that the histone deacetylase Sir2/SIRT1 is a key mediator. Moreover, resveratrol (RSV), a plant derived polyphenol, was shown to increase SIRT1 catalytic activity and mimics many aspects of CR in all eukaryotes tested. Therefore, RSV displays great promise in the prevention of illness and delay the aging process.
authors.affiliation: University of Texas Medical Branch, Galveston 77555, USA.
authors.forename: Yan-Shi
authors.initials: YS
authors.lastname: Guo
mesh_terms: D000375:Aging / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D031204:Caloric Restriction; D056545:Group III Histone Deacetylases / Q000187:drug effects; D006801:Humans; D000077185:Resveratrol; D056564:Sirtuin 1 / Q000187:drug effects; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D013267:Stilbenes; D056545:Group III Histone Deacetylases; D056564:Sirtuin 1; D000077185:Resveratrol