title: Clinical laboratory implementation of cytogenomic microarrays.
abstract: Examination of the whole genome for copy number alterations by microarray is now routinely done in many laboratories. The field of cytogenetics has evolved to adapt this technology, and the current phase of transition has resulted in the need for standardization in methodologies and interpretation of data. This review will outline some of the changes addressed in the field over the last several years and briefly discuss some of the trends in data processing, analysis and interpretation.
authors.affiliation: Department of Pediatrics, ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories, University of Utah School of Medicine, Salt Lake City, Utah, USA.
authors.forename: S T
authors.initials: ST
authors.lastname: South
authors.forename: A R
authors.initials: AR
authors.lastname: Brothman
mesh_terms: D000818:Animals; D055028:Comparative Genomic Hybridization / Q000379:methods* / Q000592:standards; D020732:Cytogenetic Analysis / Q000379:methods / Q000592:standards; D056915:DNA Copy Number Variations; D003627:Data Interpretation, Statistical; D018628:Gene Dosage; D055106:Genome-Wide Association Study; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods* / Q000592:standards; D020641:Polymorphism, Single Nucleotide; D015203:Reproducibility of Results; D012984:Software