title: A case-control study between the gene polymorphisms of polyunsaturated fatty acids metabolic rate-limiting enzymes and coronary artery disease in a Chinese Han population.
abstract: To investigate the association between the polymorphisms of fatty acid desaturase 1 (FADS1), fatty acid desaturase 2 (FADS2) and elongation of very long chain fatty acids like 2 (ELOVL2) gene and coronary artery disease (CAD) in a Chinese Han population. Three single nucleotide polymorphisms (SNPs) from these genes were genotyped using PCR-based restriction fragment length polymorphism analysis in 199 CAD cases and 192 controls of Han Chinese origin. rs174556 in the FADS1 gene showed allelic (P=0.002) and genotypic (P=0.030) association with the disease, while there was no disease association for the other two SNPs. The frequency of rs174556 minor allele (T) was significantly higher in the case group than the control group. The trans phase gene-gene interaction analysis showed that the combined genotype of rs174556 (T/T) and rs3756963 (T/T) was weakly associated with the disease (P=0.043). rs174556 in the FADS1 gene is very likely to be associated with CAD in the Chinese Han population.
authors.affiliation: Department of Cardiology, First Hospital, Jilin University, Changchun 130031, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Qin
authors.forename: Lin
authors.initials: L
authors.lastname: Sun
authors.forename: Lin
authors.initials: L
authors.lastname: Ye
authors.forename: Jieping
authors.initials: J
authors.lastname: Shi
authors.forename: Liting
authors.initials: L
authors.lastname: Zhou
authors.forename: Jingyu
authors.initials: J
authors.lastname: Yang
authors.forename: Bing
authors.initials: B
authors.lastname: Du
authors.forename: Zikai
authors.initials: Z
authors.lastname: Song
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Yu
authors.forename: Lin
authors.initials: L
authors.lastname: Xie
mesh_terms: D000123:Acetyltransferases / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D016022:Case-Control Studies; D002681:China; D003324:Coronary Artery Disease / Q000201:enzymology / Q000235:genetics*; D000090943:Delta-5 Fatty Acid Desaturase; D004843:Epistasis, Genetic; D044943:Fatty Acid Desaturases / Q000235:genetics*; D000081031:Fatty Acid Elongases; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D000090943:Delta-5 Fatty Acid Desaturase; C000630967:ELOVL2 protein, human; D005231:Fatty Acids, Unsaturated; D044943:Fatty Acid Desaturases; C000716847:FADS1 protein, human; C533241:FADS2 protein, human; D000123:Acetyltransferases; D000081031:Fatty Acid Elongases