title: [Danger signals and inflammasomes in autoinflammatory and autoimmune diseases].
abstract: Cytoplasmic inflammasomes are formed through activation of pattern recognition receptors (PRR) of the innate immune system. Endogenous and exogenous danger signals, e.g. DNA- and RNA-fragments, urate- and cholesterol crystals, silica and asbestos, ß-amyloid, UV-light and skin irritants, may induce NOD-like receptor protein (NLRP)3 inflammasomes. These inflammasomes govern the induction of proinflammatory cytokines such as IL-1ß, IL-18 and IL-33. PRR and inflammasome dysfunctions may underly immunoinflammatory diseases such as gout and other arthritides, type 1 diabetes and arteriosclerosis.
authors.affiliation: Institut for Inflammationsforskning, Rigshospitalet, Blegdamsvej 9, 2100 København Ø, Denmark. klausben@me.com
authors.forename: Klaus
authors.initials: K
authors.lastname: Bendtzen
mesh_terms: D001161:Arteriosclerosis / Q000276:immunology; D001168:Arthritis / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D016207:Cytokines / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology; D056660:Hereditary Autoinflammatory Diseases / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D058847:Inflammasomes / Q000276:immunology*; D007249:Inflammation / Q000276:immunology*; D053472:Nod Signaling Adaptor Proteins / Q000276:immunology; D051192:Receptors, Pattern Recognition / Q000276:immunology; D018124:Receptors, Tumor Necrosis Factor / Q000276:immunology; D051193:Toll-Like Receptors / Q000276:immunology
chemical_list: D016207:Cytokines; D058847:Inflammasomes; D053472:Nod Signaling Adaptor Proteins; D051192:Receptors, Pattern Recognition; D018124:Receptors, Tumor Necrosis Factor; D051193:Toll-Like Receptors