title: Mannose binding lectin mediated complement pathway in multiple sclerosis.
abstract: Role of mannose binding lectin (MBL) complement activation pathway, an arm of innate immunity in multiple sclerosis (MS) was evaluated by analyzing the expression of MBL, MBL-associated serine protease-2 (MASP-2), and functional MBL/MASP-2 mediated C4 cleavage (fMBL) in 87 plasma and cerebrospinal fluid (CSF) samples from MS patients and non-MS controls. Median fMBL and MASP-2 plasma levels were higher in MS vs. non-MS cases. These associations remained in an analysis of subtypes of MS disease. These findings suggest a potential activation of MBL complement pathway in MS that may possibly alter the risk or progression of MS disease.
authors.affiliation: Department of Pediatrics, University of California-San Diego, La Jolla, CA 92093, United States.
authors.forename: Janet Y
authors.initials: JY
authors.lastname: Kwok
authors.forename: Florin
authors.initials: F
authors.lastname: Vaida
authors.forename: Ryan M
authors.initials: RM
authors.lastname: Augst
authors.forename: Denise Y
authors.initials: DY
authors.lastname: Yu
authors.forename: Kumud K
authors.initials: KK
authors.lastname: Singh
mesh_terms: D003167:Complement Activation / Q000276:immunology*; D003181:Complement C4 / Q000378:metabolism*; D037582:Complement Pathway, Mannose-Binding Lectin / Q000502:physiology*; D018450:Disease Progression; D006801:Humans; D037601:Mannose-Binding Lectin / Q000097:blood / Q000502:physiology*; D050606:Mannose-Binding Protein-Associated Serine Proteases / Q000096:biosynthesis / Q000502:physiology; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D012307:Risk Factors
chemical_list: D003181:Complement C4; D037601:Mannose-Binding Lectin; C105296:MASP2 protein, human; D050606:Mannose-Binding Protein-Associated Serine Proteases