title: [Effect of cinobufacini injection on the tumor growth of tumor bearing rats of different constitutions].
abstract: OBJECTIVE
  To observe effects of cold- and hot-property herbs and effects of hot and cold constitutions on the tumor growth of tumor bearing rats, and to observe the effect of Cinobufacini Injection (CI) on the tumor growth of tumor bearing rats of different constitutions.
  
  
  METHODS
  Eighty healthy male Wistar rats were randomly divided into eight groups, i.e., the tumor bearing control group, the tumor bearing heat syndrome group, the tumor bearing cold syndrome group, the heat syndrome tumor bearing group, the cold syndrome tumor bearing group, the tumor bearing CI group, the heat syndrome tumor bearing CI group, and the cold syndrome tumor bearing CI group, respectively. The weight and volume of rats' subcutaneous tumor were measured 14 days after tumor inoculation.
  
  
  RESULTS
  The weight and volume of tumor in the heat syndrome tumor bearing CI group [(3.55 +/- 1.12) g, (2864.44 +/- 1430.51) mm3] and the tumor bearing CI group [(4.29 +/- 1.14) g, (3397.19 +/- 1701.13) mm3] were significantly lower than those of the tumor bearing control group [(6.01 +/- 2.45) g, (6218.91 +/- 3837.64) mm3] and the cold syndrome tumor bearing CI group [(6.90 +/- 1.57) g, (6168.42 +/- 2457.03) mm3], showing statistical difference (P<0.05). There was insignificant difference among other groups.
  
  
  CONCLUSIONS
  CI showed better tumor inhibition effects on tumor bearing rats of heat syndrome constitution, which indicated CI was of cold property. It might be possibly used in tumor bearing rats of heat syndrome constitution.
authors.affiliation: Department of Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433.
authors.forename: Shuang-shuang
authors.initials: SS
authors.lastname: Wang
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Zhai
authors.forename: Bai
authors.initials: B
authors.lastname: Li
mesh_terms: D000818:Animals; D002018:Bufanolides / Q000494:pharmacology* / Q000627:therapeutic use; D007267:Injections; D008297:Male; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002018:Bufanolides; C002471:cinobufagin