title: Impact of different adiposity measures on the relation between serum uric acid and blood pressure in young adults.
abstract: Serum uric acid (SUA) concentration is independently associated with blood pressure (BP) in adults. We examined this association in young adults at an age where anti-hypertension treatment, other potential confounding factors and co-morbidity are unlikely to occur. We assessed BP, anthropometric variables including weight, height, waist circumference (WC), body fat percent (using bioimpedance), lifestyle behaviors, SUA and blood lipids in 549 participants aged 19-20 years from a population-based cohort study (Seychelles Child Development Study). Mean (s.d.) SUA was higher in males than females, 0.33 (0.08) and 0.24 (0.07) mmol l(-1), respectively. Body mass index (BMI) was higher in females than males but BP was markedly higher in males than in females. SUA was associated with both systolic and diastolic BP. However, the magnitude of the linear regression coefficients relating BP and SUA decreased by up to 50% upon adjustment for BMI, WC or body fat percent. The association between SUA and BP was not altered upon further adjustment for alcohol intake, smoking, triglycerides or renal function. In fully adjusted models, SUA remained associated with BP (P<0.05) in females. In conclusion, adiposity substantially decreased the association between SUA and BP in young adults, and BP was independently associated with SUA in females. These findings suggest a role of adiposity in the link between hyperuricemia and hypertension.
authors.affiliation: Institute of Social and Preventive Medicine, University of Lausanne, Lausanne, Switzerland.
authors.forename: T
authors.initials: T
authors.lastname: Lyngdoh
authors.forename: B
authors.initials: B
authors.lastname: Viswanathan
authors.forename: G J
authors.initials: GJ
authors.lastname: Myers
authors.forename: M
authors.initials: M
authors.lastname: Bochud
authors.forename: P
authors.initials: P
authors.lastname: Bovet
mesh_terms: D050154:Adiposity / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D015992:Body Mass Index; D015331:Cohort Studies; D017097:Electric Impedance; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology; D008297:Male; D008954:Models, Biological; D012737:Sex Factors; D012750:Seychelles; D014527:Uric Acid / Q000097:blood*; D055105:Waist Circumference / Q000502:physiology; D055815:Young Adult
chemical_list: D014527:Uric Acid