title: Organocatalytic High Enantioselective Synthesis of β-Formyl-α-hydroxyphosphonates.
abstract: The cross aldol reaction between enolizable aldehydes and α-ketophosphonates was achieved for the first time by using 9-amino-9-deoxy-epi-quinine as the catalyst. β-Formyl-α-hydroxyphosphonates were obtained in high to excellent enantioselectivities. The reaction works especially well with acetaldehyde, which is a tough substrate for organocatalyzed cross aldol reactions. The products were demonstrated to have anticancer activities.
authors.affiliation: Department of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA.
authors.forename: Sandun
authors.initials: S
authors.lastname: Perera
authors.forename: Vijaya Kumar
authors.initials: VK
authors.lastname: Naganaboina
authors.forename: Long
authors.initials: L
authors.lastname: Wang
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.forename: Qunsheng
authors.initials: Q
authors.lastname: Guo
authors.forename: Laxmidhar
authors.initials: L
authors.lastname: Rout
authors.forename: Cong-Gui
authors.initials: CG
authors.lastname: Zhao