title: A function for quality evaluation of retinal vessel segmentations.
abstract: Retinal blood vessel assessment plays an important role in the diagnosis of ophthalmic pathologies. The use of digital images for this purpose enables the application of a computerized approach and has fostered the development of multiple methods for automated vascular tree segmentation. Metrics based on contingency tables for binary classification have been widely used for evaluating the performance of these algorithms. Metrics from this family are based on the measurement of a success or failure rate in the detected pixels, obtained by means of pixel-to-pixel comparison between the automated segmentation and a manually-labeled reference image. Therefore, vessel pixels are not considered as a part of a vascular structure with specific features. This paper contributes a function for the evaluation of global quality in retinal vessel segmentations. This function is based on the characterization of vascular structures as connected segments with measurable area and length. Thus, its design is meant to be sensitive to anatomical vascularity features. Comparison of results between the proposed function and other general quality evaluation functions shows that this proposal renders a high matching degree with human quality perception. Therefore, it can be used to enhance quality evaluation in retinal vessel segmentations, supplementing the existing functions. On the other hand, from a general point of view, the applied concept of measuring descriptive properties may be used to design specialized functions aimed at segmentation quality evaluation in other complex structures.
authors.affiliation: Department of Mathematics, La Rábida High Technical School of Engineering, University of Huelva, 21071 Palos de la Frontera, Spain. gegundez@uhu.es
authors.forename: Manuel Emilio
authors.initials: ME
authors.lastname: Gegúndez-Arias
authors.forename: Arturo
authors.initials: A
authors.lastname: Aquino
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Bravo
authors.forename: Diego
authors.initials: D
authors.lastname: Marín
mesh_terms: D000465:Algorithms; D006801:Humans; D007089:Image Enhancement / Q000379:methods / Q000592:standards; D007090:Image Interpretation, Computer-Assisted / Q000379:methods* / Q000592:standards; D021621:Imaging, Three-Dimensional / Q000379:methods* / Q000592:standards; D015588:Observer Variation; D010363:Pattern Recognition, Automated / Q000379:methods* / Q000592:standards; D011785:Quality Assurance, Health Care / Q000379:methods; D015203:Reproducibility of Results; D012171:Retinal Vessels / Q000033:anatomy & histology*; D042262:Retinoscopy / Q000379:methods* / Q000592:standards; D012680:Sensitivity and Specificity; D013030:Spain