title: Relationship between the change in left ventricular hypertrophy and asleep blood pressure after sodium restriction and/or diuretic treatment.
abstract: BACKGROUND
  Salt restriction and/or diuretic treatment convert nondippers to dippers; however, few reports have compared the relationships among the changes in asleep ambulatory blood pressure, left ventricular mass index(LVMI), and relative wall thickness between nondippers and dippers.
  
  
  METHODS
  We treated 30 never-treated hypertensive outpatients [office blood pressure (OBP) > 140/90 mmHg]with salt restriction (NaCl < 6 g/day) and/or indapamide(1 or 2 mg/day) to control both OBP (< 140/90 mmHg) and home BP (< 135/85 mmHg) for 4 months. OBP and home BP (measured monthly), ambulatory blood pressure, and echocardiogram (measured at the baseline and at the end of the treatment period) were evaluated.
  
  
  RESULTS
  There were 12 nondippers [asleep/awake systolic BP (SBP) ratio > 0.90] and 18 dippers. Asleep SBP/diastolic BP decreased in both nondippers(149 ± 19/81 ± 16 – 126 ± 22/74 ± 13 mmHg) and dippers(129 ± 9/81 ± 8 – 121 ± 9/74 ± 10 mmHg; P between groups =0.005/0.11). LVMI significantly decreased in nondippers (116 ± 17.3 – 82 ± 27.8 kg/m2; P = 0.02), but not in dippers (P = 0.31; P between groups =0.11).The change in RWT was significantly different between nondippers (0.50 ± 0.07 – 0.47 ± 0.10) and dippers(0.43 ± 0.07 – 0.45 ± 0.07; P between groups = 0.036).
authors.affiliation: Division of Cardiovascular Medicine, Department of Internal Medicine,Jichi Medical University School of Medicine, Tochigi, Japan. george@jichi.ac.jp
authors.forename: Joji
authors.initials: J
authors.lastname: Ishikawa
authors.forename: Kazuo
authors.initials: K
authors.lastname: Eguchi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hoshide
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Shimada
authors.forename: Kazuomi
authors.initials: K
authors.lastname: Kario
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm; D004039:Diet, Sodium-Restricted; D004232:Diuretics / Q000627:therapeutic use*; D004452:Echocardiography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000503:physiopathology*; D007190:Indapamide / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012890:Sleep / Q000502:physiology*
chemical_list: D004232:Diuretics; D007190:Indapamide