title: Autism spectrum disorder: does neuroimaging support the DSM-5 proposal for a symptom dyad? A systematic review of functional magnetic resonance imaging and diffusion tensor imaging studies.
abstract: A systematic review of 208 studies comprising functional magnetic resonance imaging and diffusion tensor imaging data in patients with 'autism spectrum disorder' (ASD) was conducted, in order to determine whether these data support the forthcoming DSM-5 proposal of a social communication and behavioral symptom dyad. Studies consistently reported abnormal function and structure of fronto-temporal and limbic networks with social and pragmatic language deficits, of temporo-parieto-occipital networks with syntactic-semantic language deficits, and of fronto-striato-cerebellar networks with repetitive behaviors and restricted interests in ASD patients. Therefore, this review partially supports the DSM-5 proposal for the ASD dyad.
authors.affiliation: Child and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, C/Ibiza 43, Madrid 28009, Spain. lpina@iisgm.com
authors.forename: Laura
authors.initials: L
authors.lastname: Pina-Camacho
authors.forename: Sonia
authors.initials: S
authors.lastname: Villero
authors.forename: David
authors.initials: D
authors.lastname: Fraguas
authors.forename: Leticia
authors.initials: L
authors.lastname: Boada
authors.forename: Joost
authors.initials: J
authors.lastname: Janssen
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Navas-Sánchez
authors.forename: Maria
authors.initials: M
authors.lastname: Mayoral
authors.forename: Cloe
authors.initials: C
authors.lastname: Llorente
authors.forename: Celso
authors.initials: C
authors.lastname: Arango
authors.forename: Mara
authors.initials: M
authors.lastname: Parellada
mesh_terms: D020817:Asperger Syndrome / Q000175:diagnosis / Q000503:physiopathology; D001321:Autistic Disorder / Q000175:diagnosis / Q000503:physiopathology; D001921:Brain / Q000098:blood supply / Q000503:physiopathology; D001931:Brain Mapping; D002648:Child; D002653:Child Behavior Disorders / Q000175:diagnosis / Q000503:physiopathology; D002659:Child Development Disorders, Pervasive / Q000175:diagnosis* / Q000503:physiopathology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007805:Language Development Disorders / Q000175:diagnosis / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D009415:Nerve Net / Q000503:physiopathology; D010100:Oxygen / Q000097:blood; D012039:Regional Blood Flow / Q000502:physiology; D012919:Social Behavior; D013239:Stereotyped Behavior / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D010100:Oxygen