title: Hemophagocytic syndrome associated with Plasmodium falciparum infection.
abstract: Hemophagocytic syndrome (HPS) has been associated with infections, hematological malignancies and autoimmune conditions. Malaria is rarely reported to cause HPS. We report a case of an 11-month-old infant with fever, hepatosplenomegaly, pancytopenia, high serum ferritin, hypertriglyceridemia, and bone marrow hemophagocytosis, consistent with hemophagocytic syndrome. Gametocytes of plasmodium falciparum were identified on bone marrow aspiration. Rapid recovery was observed after treatment with antimalarials.
authors.affiliation: Department of Pediatrics, Sri Ramachandra Medical College, Chennai, India.
authors.forename: P N
authors.initials: PN
authors.lastname: Vinoth
authors.forename: K Abilash
authors.initials: KA
authors.lastname: Thomas
authors.forename: S Muthamil
authors.initials: SM
authors.lastname: Selvan
authors.forename: D Febe Renjitha
authors.initials: DF
authors.lastname: Suman
authors.forename: Julius Xavier
authors.initials: JX
authors.lastname: Scott
mesh_terms: D000962:Antimalarials / Q000008:administration & dosage; D001853:Bone Marrow / Q000469:parasitology / Q000473:pathology; D006801:Humans; D007223:Infant; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis* / Q000209:etiology*; D016778:Malaria, Falciparum / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008853:Microscopy; D010963:Plasmodium falciparum / Q000166:cytology; D016896:Treatment Outcome
chemical_list: D000962:Antimalarials