title: Fulminant ulcerative colitis despite maximal immunosuppression following liver transplantation: a case report and literature review.
abstract: Inflammatory Bowel Disease (IBD) is thought to be the result of an overly aggressive immune response to ubiquitous antigens. Immuno -modulation and -suppression is therefore currently the treatment of choice. It was long anticipated that the course of pre-existing IBD should improve after orthotopic liver transplantation (OLT) due to increased immunosuppression. We report the case of a patient who developed acute fulminant colitis despite triple immunosuppression and mesalazine and review the relevant literature.
authors.affiliation: Gastroenterology Unit, Southern District Health Board, Dunedin, New Zealand.
authors.forename: Antony
authors.initials: A
authors.lastname: Pan
authors.forename: Martin
authors.initials: M
authors.lastname: Schlup
authors.forename: Ralf
authors.initials: R
authors.lastname: Lubcke
authors.forename: Michael
authors.initials: M
authors.lastname: Schultz
mesh_terms: D015209:Cholangitis, Sclerosing / Q000150:complications / Q000601:surgery*; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000209:etiology / Q000517:prevention & control* / Q000601:surgery; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016031:Liver Transplantation; D019804:Mesalamine / Q000627:therapeutic use; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D012008:Recurrence; D016559:Tacrolimus / Q000627:therapeutic use
chemical_list: D007166:Immunosuppressive Agents; D019804:Mesalamine; D009173:Mycophenolic Acid; D011241:Prednisone; D016559:Tacrolimus