title: Seroepidemiology of the newly found trichodysplasia spinulosa-associated polyomavirus.
abstract: Trichodysplasia spinulosa (TS)-associated polyomavirus (TSV) was recently (in 2010) discovered in TS lesions. To investigate the seroprevalence and primary exposure time of this virus, we set up a virus protein (VP1) viruslike particle (VLP)-based immunoglobulin G enzyme immunoassay. The seroprevalence of TSV was 5%, among children aged 1-4 years, rising to 48% at 6-10 years, and 70% among 149 adults. The TSV antibodies did not cross-react with corresponding Merkel cell polyomavirus VLPs, and their reactivity appeared conformational. TSV circulates widely in the human population and primary exposure is extensive in childhood, beginning at age 1-2 years.
authors.affiliation: Department of Virology, Haartman Institute, Finland.
authors.forename: Tingting
authors.initials: T
authors.lastname: Chen
authors.forename: Petri S
authors.initials: PS
authors.lastname: Mattila
authors.forename: Tuomas
authors.initials: T
authors.lastname: Jartti
authors.forename: Olli
authors.initials: O
authors.lastname: Ruuskanen
authors.forename: Maria
authors.initials: M
authors.lastname: Söderlund-Venermo
authors.forename: Klaus
authors.initials: K
authors.lastname: Hedman
mesh_terms: D000328:Adult; D000367:Age Factors; D000914:Antibodies, Viral / Q000097:blood* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003429:Cross Reactions; D005148:Facial Dermatoses / Q000821:virology*; D005387:Finland / Q000453:epidemiology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood* / Q000276:immunology; D007223:Infant; D011120:Polyomavirus / Q000276:immunology* / Q000302:isolation & purification*; D027601:Polyomavirus Infections / Q000097:blood / Q000453:epidemiology*; D016036:Seroepidemiologic Studies; D014412:Tumor Virus Infections / Q000097:blood / Q000453:epidemiology*
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G