title: Pulmonary hypertension and reopening of the ductus arteriosus in an infant treated with diazoxide.
abstract: Diazoxide is the main therapeutic agent for persistent hyperinsulinemic hypoglycemia. Generally, it is tolerated well, but rarely it can cause severe life-threatening complications. We report a neonate who was treated with diazoxide for hyperinsulinemic hypoglycemia. On the 6th day of the treatment we observed sepsis-mimicking symptoms, mild pulmonary hypertension, and re-opening of the ductus arteriosus. All these findings resolved dramatically shortly after discontinuation of treatment. To our knowledge, this is the first reported case of re-opening of the ductus arteriosus due to diazoxide toxicity.
authors.affiliation: Department of Pediatric Endocrinology, Ankara Child Diseases, Hematology and Oncology Training Hospital, Ankara, Turkey. demirelf@gmail.com
authors.forename: Fatma
authors.initials: F
authors.lastname: Demirel
authors.forename: Sevim
authors.initials: S
authors.lastname: Unal
authors.forename: I Ilker
authors.initials: II
authors.lastname: Çetin
authors.forename: Ihsan
authors.initials: I
authors.lastname: Esen
authors.forename: Aslihan
authors.initials: A
authors.lastname: Arasli
mesh_terms: D003937:Diagnosis, Differential; D003981:Diazoxide / Q000009:adverse effects* / Q000627:therapeutic use; D004374:Ductus Arteriosus, Patent / Q000139:chemically induced*; D006801:Humans; D006946:Hyperinsulinism / Q000188:drug therapy / Q000503:physiopathology; D006976:Hypertension, Pulmonary / Q000139:chemically induced*; D007003:Hypoglycemia / Q000209:etiology; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000627:therapeutic use; D007231:Infant, Newborn; D008297:Male; D012008:Recurrence; D018805:Sepsis / Q000175:diagnosis; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D007004:Hypoglycemic Agents; D003981:Diazoxide