title: Slipping and sliding: frameshift mutations in herpes simplex virus thymidine kinase and drug-resistance.
abstract: Some of the most successful antiviral agents currently available are effective against herpes simplex virus. However, resistance to these drugs is frequently associated with significant morbidity, particularly in immunocompromised patients. In addition to the clinical implications of drug resistance, the range of biological processes exploited by the virus to attain resistance while maintaining pathogenicity is proving to be surprising. These mechanisms, which include ribosomal frameshifting, induced infidelity of the DNA polymerase, and internal ribosome entry, are discussed.
authors.affiliation: Department of Virology and Immunology, Texas Biomedical Research Institute and Southwest National Primate Research Center, 7620 N.W. Loop 410, San Antonio, TX 78227, USA. agriffiths@txbiomed.org
authors.forename: Anthony
authors.initials: A
authors.lastname: Griffiths
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D004259:DNA-Directed DNA Polymerase / Q000235:genetics; D024882:Drug Resistance, Viral; D005090:Exodeoxyribonucleases / Q000235:genetics; D016368:Frameshift Mutation; D006561:Herpes Simplex / Q000188:drug therapy* / Q000201:enzymology / Q000821:virology; D006801:Humans; D016867:Immunocompromised Host; D018139:Simplexvirus / Q000187:drug effects / Q000201:enzymology; D013937:Thymidine Kinase / Q000235:genetics*; D014764:Viral Proteins / Q000235:genetics
chemical_list: D000998:Antiviral Agents; D014764:Viral Proteins; D013937:Thymidine Kinase; D004259:DNA-Directed DNA Polymerase; D005090:Exodeoxyribonucleases; C043417:DNA polymerase, Simplexvirus