title: Malabaricone C from Myristica cinnamomea exhibits anti-quorum sensing activity.
abstract: A methanol-soluble extract of the bark of Myristica cinnamomea was found to exhibit anti-quorum sensing activity, and subsequent bioassay-guided isolation led to the identification of the active compound malabaricone C (1). Compound 1 inhibited violacein production by Chromobacterium violaceum CV026 when grown in the presence of a cognate signaling molecule, N-3-oxohexanoyl-homoserine lactone. Furthermore, 1 inhibited the quorum sensing-regulated pyocyanin production and biofilm formation in Pseudomonas aeruginosa PAO1. These results suggest that the anti-quorum sensing activity of 1 and related molecules should be investigated further.
authors.affiliation: Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Yee Meng
authors.initials: YM
authors.lastname: Chong
authors.forename: Wai Fong
authors.initials: WF
authors.lastname: Yin
authors.forename: Chia Yong
authors.initials: CY
authors.lastname: Ho
authors.forename: Mohamad Rais
authors.initials: MR
authors.lastname: Mustafa
authors.forename: A Hamid A
authors.initials: AH
authors.lastname: Hadi
authors.forename: Khalijah
authors.initials: K
authors.lastname: Awang
authors.forename: Putri
authors.initials: P
authors.lastname: Narrima
authors.forename: Chong-Lek
authors.initials: CL
authors.lastname: Koh
authors.forename: David R
authors.initials: DR
authors.lastname: Appleton
authors.forename: Kok-Gan
authors.initials: KG
authors.lastname: Chan
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000378:metabolism; D002861:Chromobacterium / Q000378:metabolism*; D006801:Humans; D007211:Indoles / Q000037:antagonists & inhibitors / Q000378:metabolism; D008296:Malaysia; D026324:Myristicaceae / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011710:Pyocyanine / Q000032:analysis / Q000378:metabolism; D053038:Quorum Sensing / Q000187:drug effects*; D012118:Resorcinols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D007211:Indoles; C104908:N-hexanoyl-L-homoserine lactone; D012118:Resorcinols; C071787:malabaricone C; D011710:Pyocyanine; D015107:4-Butyrolactone; C063155:violacein