title: Genome-wide association mapping reveals a rich genetic architecture of complex traits in Oryza sativa.
abstract: Asian rice, Oryza sativa is a cultivated, inbreeding species that feeds over half of the world's population. Understanding the genetic basis of diverse physiological, developmental, and morphological traits provides the basis for improving yield, quality and sustainability of rice. Here we show the results of a genome-wide association study based on genotyping 44,100 SNP variants across 413 diverse accessions of O. sativa collected from 82 countries that were systematically phenotyped for 34 traits. Using cross-population-based mapping strategies, we identified dozens of common variants influencing numerous complex traits. Significant heterogeneity was observed in the genetic architecture associated with subpopulation structure and response to environment. This work establishes an open-source translational research platform for genome-wide association studies in rice that directly links molecular variation in genes and metabolic pathways with the germplasm resources needed to accelerate varietal development and crop improvement.
authors.affiliation: Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York 14850, USA.
authors.forename: Keyan
authors.initials: K
authors.lastname: Zhao
authors.forename: Chih-Wei
authors.initials: CW
authors.lastname: Tung
authors.forename: Georgia C
authors.initials: GC
authors.lastname: Eizenga
authors.forename: Mark H
authors.initials: MH
authors.lastname: Wright
authors.forename: M Liakat
authors.initials: ML
authors.lastname: Ali
authors.forename: Adam H
authors.initials: AH
authors.lastname: Price
authors.forename: Gareth J
authors.initials: GJ
authors.lastname: Norton
authors.forename: M Rafiqul
authors.initials: MR
authors.lastname: Islam
authors.forename: Andy
authors.initials: A
authors.lastname: Reynolds
authors.forename: Jason
authors.initials: J
authors.lastname: Mezey
authors.forename: Anna M
authors.initials: AM
authors.lastname: McClung
authors.forename: Carlos D
authors.initials: CD
authors.lastname: Bustamante
authors.forename: Susan R
authors.initials: SR
authors.lastname: McCouch
mesh_terms: D018740:Genetic Heterogeneity; D008040:Genetic Linkage; D018745:Genome, Plant; D005838:Genotype; D012275:Oryza / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide