title: Heavily fluorinated carbohydrates as enzyme substrates: oxidation of tetrafluorinated galactose by galactose oxidase.
abstract: Galactose oxidase (GOase) was shown to oxidise several C2/C3 fluorinated galactose analogues. Interestingly, the enzyme was able to distinguish between the 2,3-tetrafluorinated galactose and its epimeric glucose analogue, and this represents the first reported biotransformation of a heavily fluorinated sugar.
authors.affiliation: MIB & School of Chemistry, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK.
authors.forename: Avgousta
authors.initials: A
authors.lastname: Ioannou
authors.forename: Elena
authors.initials: E
authors.lastname: Cini
authors.forename: Roxana S
authors.initials: RS
authors.lastname: Timofte
authors.forename: Sabine L
authors.initials: SL
authors.lastname: Flitsch
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Turner
authors.forename: Bruno
authors.initials: B
authors.lastname: Linclau
mesh_terms: D005690:Galactose / Q000737:chemistry* / Q000378:metabolism*; D005692:Galactose Oxidase / Q000378:metabolism*; D005947:Glucose / Q000737:chemistry / Q000378:metabolism; D054879:Halogenation; D007536:Isomerism; D007700:Kinetics; D010084:Oxidation-Reduction; D013379:Substrate Specificity
chemical_list: D005692:Galactose Oxidase; D005947:Glucose; D005690:Galactose