title: Spectroscopic and photophysical properties of protonated forms of some fluoroquinolones in solutions.
abstract: Electronic absorption and fluorescence spectra of ciprofloxacin, norfloxacin, enoxacin, pefloxacin and nalidixic acid in aqueous solutions were investigated. The time-resolved fluorescence spectra were measured and interpreted. The changes of the luminescence spectra and electron structure of the compounds under study are explained by different degrees of the spin-orbital interaction caused by nitrogen heteroatoms lone pairs effect. Possible ways of the protonation process for naphtyridine and quinolone rings with different substitutions are discussed. The photophysical behavior of FQs was studied using density functional theory (DFT) calculations.
authors.affiliation: Department of Chemistry, University of Turku, FI-20014, Turku, Finland.
authors.forename: A V
authors.initials: AV
authors.lastname: Polishchuk
authors.forename: E T
authors.initials: ET
authors.lastname: Karaseva
authors.forename: T B
authors.initials: TB
authors.lastname: Emelina
authors.forename: V E
authors.initials: VE
authors.lastname: Karasev
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D024841:Fluoroquinolones / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008958:Models, Molecular; D008968:Molecular Conformation; D009584:Nitrogen / Q000737:chemistry; D011522:Protons; D011789:Quantum Theory; D012996:Solutions; D013057:Spectrum Analysis
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D011522:Protons; D012996:Solutions; D009584:Nitrogen