title: Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation pronouncedly underestimates glomerular filtration rate in type 2 diabetes.
abstract: OBJECTIVE To evaluate the performance of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation to estimate glomerular filtration rate (GFR) in type 2 diabetic patients with GFR >60 mL/min/1.73 m(2). RESEARCH DESIGN AND METHODS This was a cross-sectional study including 105 type 2 diabetic patients. GFR was measured by (51)Cr-EDTA method and estimated by the MDRD and CKD-EPI equations. Serum creatinine was measured by the traceable Jaffe method. Bland-Altman plots were used. Bias, accuracy (P30), and precision were evaluated. RESULTS The mean age of patients was 57 ± 8 years; 53 (50%) were men and 90 (86%) were white. Forty-six (44%) patients had microalbuminuria, and 14 (13%) had macroalbuminuria. (51)Cr-EDTA GFR was 103 ± 23, CKD-EPI GFR was 83 ± 15, and MDRD-GFR was 78 ± 17 mL/min/1.73 m² (P < 0.001). Accuracy (95% CI) was 67% (58-74) for CKD-EPI and 64% (56-75) for MDRD. Precision was 21 and 22, respectively. CONCLUSIONS The CKD-EPI and MDRD equations pronouncedly underestimated GFR in type 2 diabetic patients.
authors.affiliation: Graduate PrograminMedical Sciences: Endocrinology, Universidade Federal do Rio Grande do Sul, Rio Grande do Sul, Brazil. sandrasilveiro@terra.com.br
authors.forename: Sandra P
authors.initials: SP
authors.lastname: Silveiro
authors.forename: Gustavo N
authors.initials: GN
authors.lastname: Araújo
authors.forename: Mariana N
authors.initials: MN
authors.lastname: Ferreira
authors.forename: Fabíola D S
authors.initials: FD
authors.lastname: Souza
authors.forename: Halley M
authors.initials: HM
authors.lastname: Yamaguchi
authors.forename: Eduardo G
authors.initials: EG
authors.lastname: Camargo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000419:Albuminuria / Q000097:blood; D001786:Blood Glucose; D001938:Brazil / Q000453:epidemiology; D003404:Creatinine / Q000097:blood*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D011237:Predictive Value of Tests; D015203:Reproducibility of Results
chemical_list: D001786:Blood Glucose; D003404:Creatinine