title: Potent inhibition of Norwalk virus by cyclic sulfamide derivatives.
abstract: A new class of compounds that exhibit anti-norovirus activity in a cell-based system and embody in their structure a cyclosulfamide scaffold has been identified. The structure of the initial hit (compound 2a, ED(50) 4 μM, TD(50) 50 μM) has been prospected by exploiting multiple points of diversity and generating appropriate structure-activity relationships.
authors.affiliation: Department of Chemistry, Wichita State University, Wichita, KS 67260, United States.
authors.forename: Dengfeng
authors.initials: D
authors.lastname: Dou
authors.forename: Kok-Chuan
authors.initials: KC
authors.lastname: Tiew
authors.forename: Guijia
authors.initials: G
authors.lastname: He
authors.forename: Sivakoteswara Rao
authors.initials: SR
authors.lastname: Mandadapu
authors.forename: Sridhar
authors.initials: S
authors.lastname: Aravapalli
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Alliston
authors.forename: Yunjeong
authors.initials: Y
authors.lastname: Kim
authors.forename: Kyeong-Ok
authors.initials: KO
authors.lastname: Chang
authors.forename: William C
authors.initials: WC
authors.lastname: Groutas
mesh_terms: D000577:Amides / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure; D009663:Norwalk virus / Q000737:chemistry / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013451:Sulfonic Acids / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000577:Amides; D013451:Sulfonic Acids; C005741:sulfamic acid