title: A Cellular Neural Network methodology for the automated segmentation of multiple sclerosis lesions.
abstract: We present a new application based on genetic algorithms (GAs) that evolves a Cellular Neural Network (CNN) capable of automatically determining the lesion load in multiple sclerosis (MS) patients from magnetic resonance imaging (MRI). In particular, it seeks to identify brain areas affected by lesions, whose presence is revealed by areas of higher intensity if compared to healthy tissue. The performance of the CNN algorithm has been quantitatively evaluated by comparing the CNN output with the expert's manual delineation of MS lesions. The CNN algorithm was run on a data set of 11 MS patients; for each one a single dataset of MRI images (matrix resolution of 256×256 pixels) was acquired. Our automated approach gives satisfactory results showing that after the learning process the CNN is capable of detecting MS lesions with different shapes and intensities (mean DICE coefficient=0.64). The system could provide a useful support tool for the evaluation of lesions in MS patients, although it needs to be evolved and developed in the future.
authors.affiliation: Neuroimaging Research Unit, Institute of Neurological Sciences, National Research Council, Germaneto (CZ) 88100, Italy. a.cerasa@isn.cnr.it
authors.forename: Antonio
authors.initials: A
authors.lastname: Cerasa
authors.forename: Eleonora
authors.initials: E
authors.lastname: Bilotta
authors.forename: Antonio
authors.initials: A
authors.lastname: Augimeri
authors.forename: Andrea
authors.initials: A
authors.lastname: Cherubini
authors.forename: Pietro
authors.initials: P
authors.lastname: Pantano
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Zito
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Lanza
authors.forename: Paola
authors.initials: P
authors.lastname: Valentino
authors.forename: Maria C
authors.initials: MC
authors.lastname: Gioia
authors.forename: Aldo
authors.initials: A
authors.lastname: Quattrone
mesh_terms: D000328:Adult; D000465:Algorithms; D001921:Brain / Q000473:pathology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000473:pathology*; D016571:Neural Networks, Computer