title: Emodepside and SL0-1 potassium channels: a review.
abstract: Nematode parasites infect humans and domestic animals; treatment and prophylaxis require anthelmintic drugs because vaccination and sanitation is limited. Emodepside is a more recently introduced cyclooctadepsipeptide drug that has actions against GI nematodes, lungworm, and microfilaria. It has a novel mode of action which breaks resistance to the classical anthelmintics (benzimidazoles, macrocyclic lactones and cholinergic agonists). Here we review studies on its mode of action which suggest that it acts to inhibit neuronal and muscle activity of nematodes by increasing the opening of calcium-activated potassium (SLO-1) channels.
authors.affiliation: Department of Biomedical Sciences, Iowa State University, Ames, IA 50011-1250, USA. rjmartin@iastate.edu
authors.forename: R J
authors.initials: RJ
authors.lastname: Martin
authors.forename: S K
authors.initials: SK
authors.lastname: Buxton
authors.forename: C
authors.initials: C
authors.lastname: Neveu
authors.forename: C L
authors.initials: CL
authors.lastname: Charvet
authors.forename: A P
authors.initials: AP
authors.lastname: Robertson
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology* / Q000627:therapeutic use; D017173:Caenorhabditis elegans / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D047630:Depsipeptides / Q000494:pharmacology* / Q000627:therapeutic use; D004351:Drug Resistance; D006801:Humans; D051036:Large-Conductance Calcium-Activated Potassium Channels / Q000187:drug effects* / Q000378:metabolism; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009348:Nematoda / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D009349:Nematode Infections / Q000188:drug therapy* / Q000469:parasitology / Q000517:prevention & control; D009469:Neuromuscular Junction / Q000187:drug effects / Q000378:metabolism; D009479:Neuropeptides / Q000378:metabolism; D018000:Receptors, Peptide / Q000187:drug effects / Q000378:metabolism
chemical_list: D000871:Anthelmintics; D047630:Depsipeptides; D051036:Large-Conductance Calcium-Activated Potassium Channels; D009479:Neuropeptides; D018000:Receptors, Peptide; C034800:alpha-latrotoxin receptor; C468987:emodepside