title: Anatomical and functional macular changes after rhegmatogenous retinal detachment with macula off.
abstract: OBJECTIVE
  To evaluate the correlation between morphologic changes in the outer retina and visual function after successful repair of rhegmatogenous retinal detachment with macula off.
  
  
  METHODS
  Observational case series.
  
  
  METHODS
  
  
  
  METHODS
  Dijon University Hospital.
  
  
  METHODS
  Thirty patients (30 eyes) with successful repair of rhegmatogenous retinal detachment after macula off and a minimum 6-month follow-up after surgery.
  
  
  METHODS
  Spectral-domain optical coherence tomography (SD-OCT) of the outer retina, fundus autofluorescence (FAF), and microperimetry.
  
  
  RESULTS
  Twenty of 30 eyes presented microstructural changes within the photoreceptor layer (66.7%). Of these, half of the patients (50%) had more than 1 lesion. Disrupted inner segment/outer segment (IS/OS) junction was noted in 16 out of 30 eyes (53.3%), irregular hyporeflectivity in the photoreceptor outer segments (PROS) was observed in 17 eyes (56.7%), external limiting membrane was discontinued in 10 eyes (33.3%), and hyperreflective spots in the outer nuclear layer were observed in 5 eyes (16.7%). FAF changes were detected in only 5 eyes (16.7%). Abnormalities in the IS/OS junction were significantly associated with lower foveal and macular sensitivity, thinner PROS, and global photoreceptor changes (P = .014, P = .003, P = .006, P < .0001, respectively). Patients with a normal foveal profile showed similar findings.
  
  
  CONCLUSIONS
  SD-OCT and microperimetry seem to be appropriate tools to determine the visual and the anatomic recovery of the macula after surgery.
authors.affiliation: Department of Ophthalmology, University Hospital, Dijon, France.
authors.forename: Marie Pierre
authors.initials: MP
authors.lastname: Delolme
authors.forename: Brice
authors.initials: B
authors.lastname: Dugas
authors.forename: Frédéric
authors.initials: F
authors.lastname: Nicot
authors.forename: Aurore
authors.initials: A
authors.lastname: Muselier
authors.forename: Alain M
authors.initials: AM
authors.lastname: Bron
authors.forename: Catherine
authors.initials: C
authors.lastname: Creuzot-Garcher
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D058450:Endotamponade; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D020419:Photoreceptor Cells, Vertebrate / Q000473:pathology*; D012163:Retinal Detachment / Q000503:physiopathology / Q000601:surgery*; D012189:Retrospective Studies; D012591:Scleral Buckling; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology*; D058609:Visual Field Tests; D014821:Vitrectomy