title: Peritoneal recurrence in serosa-negative gastric adenocarcinoma after curative surgery.
abstract: OBJECTIVE
  The rate of recurrence increases in proportion to the degree of tumor depth, even after curative resection for gastric adenocarcinoma. Serosal exposure is considered as an important risk factor of peritoneal recurrence. However, some patients with serosa-negative cancer were found to have peritoneal recurrence. There are few reports concerning risk factors of peritoneal recurrence in serosa-negative gastric adenocarcinoma. The aim of this study is to evaluate the incidence and risk factors of peritoneal recurrence in serosa-negative gastric adenocarcinoma after curative resection.
  
  
  METHODS
  Total 1128 serosa-negative gastric cancer patients (574 pT1, 251 pT2, 303 pT3) diagnosed as gastric adenocarcinoma that underwent R0 resection from 1988 to 2005 were enrolled.
  
  
  RESULTS
  Peritoneal recurrence was observed in 50 (4.4%) patients, including 3 pT1, 3 pT2 and 44 pT3 patients. The incidence of peritoneal recurrence increased significantly with tumor invading subserosa (pT3). Multivariate analysis showed that the independent risk factor of peritoneal recurrence was tumor depth.
  
  
  CONCLUSIONS
  The incidence of peritoneal recurrence in serosa-negative cancer is low, and tumor depth is a significant risk factor. We should be aware of peritoneal recurrence during follow-up, especially for patients with subserosal tumor invasion.
authors.affiliation: Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: Chun-Chi
authors.initials: CC
authors.lastname: Wu
authors.forename: Jen-Hao
authors.initials: JH
authors.lastname: Chen
authors.forename: Kuo-Hung
authors.initials: KH
authors.lastname: Huang
authors.forename: Wen-Liang
authors.initials: WL
authors.lastname: Fang
authors.forename: Chew-Wun
authors.initials: CW
authors.lastname: Wu
authors.forename: Su-Shin
authors.initials: SS
authors.lastname: Lo
authors.forename: Mao-Chih
authors.initials: MC
authors.lastname: Hsieh
authors.forename: King-Han
authors.initials: KH
authors.lastname: Shen
authors.forename: Anna Fen-Yau
authors.initials: AF
authors.lastname: Li
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000209:etiology*; D010534:Peritoneal Neoplasms / Q000209:etiology*; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery*