title: Aging-related changes in the default mode network and its anti-correlated networks: a resting-state fMRI study.
abstract: Intrinsic brain activity in a resting state incorporates components of the task negative network called default mode network (DMN) and task-positive networks called attentional networks. In the present study, the reciprocal neuronal networks in the elder group were compared with the young group to investigate the differences of the intrinsic brain activity using a method of temporal correlation analysis based on seed regions of posterior cingulate cortex (PCC) and ventromedial prefrontal cortex (vmPFC). We found significant decreased positive correlations and negative correlations with the seeds of PCC and vmPFC in the old group. The decreased coactivations in the DMN network components and their negative networks in the old group may reflect age-related alterations in various brain functions such as attention, motor control and inhibition modulation in cognitive processing. These alterations in the resting state anti-correlative networks could provide neuronal substrates for the aging brain.
authors.affiliation: Department of Radiology, Sino-Japanese Friendship Hospital, Jilin University, Changchun 130033, China.
authors.forename: Jing-Tao
authors.initials: JT
authors.lastname: Wu
authors.forename: Hui-Zhen
authors.initials: HZ
authors.lastname: Wu
authors.forename: Chao-Gan
authors.initials: CG
authors.lastname: Yan
authors.forename: Wen-Xin
authors.initials: WX
authors.lastname: Chen
authors.forename: Hong-Ying
authors.initials: HY
authors.lastname: Zhang
authors.forename: Yong
authors.initials: Y
authors.lastname: He
authors.forename: Hai-Shan
authors.initials: HS
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods / Q000706:statistics & numerical data*; D005260:Female; D006179:Gyrus Cinguli / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000502:physiology*; D017397:Prefrontal Cortex / Q000502:physiology*; D012146:Rest / Q000502:physiology*