title: Pituitary tumor apoplexy in patients with Cushing's disease: endocrinologic and visual outcomes after transsphenoidal surgery.
abstract: Pituitary apoplexy in patients with adrenocorticotropic hormone (ACTH) producing tumors is a rare occurrence. We report four patients with Cushing's disease harboring ACTH-secreting macroadenomas who presented with pituitary apoplexy. We report the endocrinologic and visual outcomes of these patients after emergent transsphenoidal surgery. A retrospective chart review was performed in 4 patients who presented with pituitary apoplexy from hemorrhage into an ACTH-secreting pituitary adenoma. The patient charts were reviewed for clinical presentation, neuroimaging findings, intraoperative surgical findings, pathologic findings, and postoperative endocrinologic and visual outcomes. All patients presented with acute headaches, nausea, vomiting, and visual loss from optic compression. MR imaging demonstrated a hemorrhagic macroadenoma that was confirmed at surgery. All patients underwent emergent transsphenoidal decompression (within 24 h of presentation). One of these underwent an additional craniotomy to resect residual tumor. Postoperatively, all patients showed significant improvement in visual acuity and visual fields with biochemical remission confirmed on laboratory testing. Significant weight loss as well as resolution of diabetes and hypertension was noted in all cases. All four patients remained in biochemical remission at their most recent follow-up visit (mean 40 months, range: 24-72 months). Excellent endocrine and visual outcomes can be achieved after emergent transsphenoidal surgery in patients with Cushing's disease presenting with pituitary apoplexy. Although the cure rates of non-apoplectic ACTH macroadenomas are generally poor, higher rates of remission can be achieved in cases of pituitary apoplexy. This may be partly due to the effects of tumor infarction.
authors.affiliation: Department of Neurological Surgery, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 90 Bergen St, Suite 8100, Newark, NJ 07101, USA.
authors.forename: Osamah J
authors.initials: OJ
authors.lastname: Choudhry
authors.forename: Asad J
authors.initials: AJ
authors.lastname: Choudhry
authors.forename: Elkin A
authors.initials: EA
authors.lastname: Nunez
authors.forename: Jean Anderson
authors.initials: JA
authors.lastname: Eloy
authors.forename: William T
authors.initials: WT
authors.lastname: Couldwell
authors.forename: Ivan S
authors.initials: IS
authors.lastname: Ciric
authors.forename: James K
authors.initials: JK
authors.lastname: Liu
mesh_terms: D049913:ACTH-Secreting Pituitary Adenoma / Q000473:pathology / Q000601:surgery*; D000236:Adenoma / Q000473:pathology / Q000601:surgery*; D000328:Adult; D005260:Female; D006801:Humans; D008875:Middle Aged; D047748:Pituitary ACTH Hypersecretion / Q000150:complications* / Q000601:surgery; D010899:Pituitary Apoplexy / Q000601:surgery*; D010911:Pituitary Neoplasms / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome