title: One-pot Diels-Alder cycloaddition/gold(I)-catalyzed 6-endo-dig cyclization for the synthesis of the complex bicyclo[3.3.1]alkenone framework.
abstract: The rapid synthesis of bicyclo[m.n.1]alkanone cores possessing quaternary carbon centers adjacent to a bridged ketone represents a significant synthetic challenge. This type of architectural feature is embedded in various complex biologically active compounds such as hyperforin and garsubellin A. Herein, we report a highly diastereoselective one-pot Diels-Alder reaction/Au(I)-catalyzed carbocyclization to generate bicyclo[3.3.1]alkanones in yields ranging from 48-93%.
authors.affiliation: Department of Chemistry, 10 Marie Curie, University of Ottawa, Ottawa, Canada, K1N 6N5.
authors.forename: Boubacar
authors.initials: B
authors.lastname: Sow
authors.forename: Gabriel
authors.initials: G
authors.lastname: Bellavance
authors.forename: Francis
authors.initials: F
authors.lastname: Barabé
authors.forename: Louis
authors.initials: L
authors.lastname: Barriault