title: Remarkable biocompatibility enhancement of porous NiTi alloys by a new surface modification approach: in-situ nitriding and in vitro and in vivo evaluation.
abstract: An in-situ nitriding method has been developed to modify the outer surface and the pore walls of both open and closed pores of porous NiTi shape memory alloys (SMAs) as part of their sintering process. XRD and XPS examinations revealed that the modified layer is mainly TiN. The biocompatibility of the in-situ nitrided sample has been characterized by its corrosion resistance, cell adherence, and implant surgery. The in-situ nitrided porous NiTi SMAs exhibit much better corrosion resistance, cell adherence, and bone tissue induced capability than the porous NiTi alloys without surface modification. Furthermore, the released Ni ion content in the blood of rabbit is reduced greatly by the in-situ nitriding. The excellent biocompatibility of in-situ nitrided sample is attributed to the formation of the TiN layer on all the pore walls including both open and closed pores.
authors.affiliation: School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, People's Republic of China.
authors.forename: H
authors.initials: H
authors.lastname: Li
authors.forename: B
authors.initials: B
authors.lastname: Yuan
authors.forename: Y
authors.initials: Y
authors.lastname: Gao
authors.forename: C Y
authors.initials: CY
authors.lastname: Chung
authors.forename: M
authors.initials: M
authors.lastname: Zhu
mesh_terms: D000497:Alloys / Q000737:chemistry* / Q000378:metabolism; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism; D001854:Bone Marrow Cells / Q000166:cytology; D001842:Bone and Bones / Q000378:metabolism / Q000473:pathology; D002478:Cells, Cultured; D003343:Corrosion; D005260:Female; D006801:Humans; D020007:Implants, Experimental; D008422:Materials Testing; D009532:Nickel / Q000737:chemistry*; D016062:Porosity; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D017154:Stromal Cells / Q000166:cytology; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D009532:Nickel; D014025:Titanium