title: FISH analysis reveals frequent co-occurrence of 4q24/TET2 and 5q and/or 7q deletions.
abstract: We investigated TET2 deletion in 418 patients with hematological malignancies. Overall interphase FISH detected complete or partial TET2 monoallelic deletion (TET2(del)) in 20/418 cases (4.7%). TET2(del) was very rare in lymphoid malignancies (1/242 cases; 0.4%). Among 19 positive myeloid malignancies TET2(del) was associated with a 4q24 karyotypic abnormality in 18 cases. In AML, TET2(del) occurred in CD34-positive hematopoietic precursors and preceded established genomic abnormalities, such as 5q- and -7/7q-, which were the most frequent associated changes (Fisher's exact test P=0.000).
authors.affiliation: Hematology and Bone Marrow Transplantation Unit, University of Perugia, Perugia, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: La Starza
authors.forename: Barbara
authors.initials: B
authors.lastname: Crescenzi
authors.forename: Valeria
authors.initials: V
authors.lastname: Nofrini
authors.forename: Gianluca
authors.initials: G
authors.lastname: Barba
authors.forename: Caterina
authors.initials: C
authors.lastname: Matteucci
authors.forename: Lucia
authors.initials: L
authors.lastname: Brandimarte
authors.forename: Valentina
authors.initials: V
authors.lastname: Pierini
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Testoni
authors.forename: Pellegrino
authors.initials: P
authors.lastname: Musto
authors.forename: Stefania
authors.initials: S
authors.lastname: Paolini
authors.forename: Valentina
authors.initials: V
authors.lastname: Gianfelici
authors.forename: Clelia T
authors.initials: CT
authors.lastname: Storlazzi
authors.forename: Antonio
authors.initials: A
authors.lastname: Pierini
authors.forename: Laura
authors.initials: L
authors.lastname: Berchicci
authors.forename: Paolo
authors.initials: P
authors.lastname: Gorello
authors.forename: Cristina
authors.initials: C
authors.lastname: Mecucci
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002872:Chromosome Deletion; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D003627:Data Interpretation, Statistical; D049308:Dioxygenases; D005260:Female; D019337:Hematologic Neoplasms / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000706:statistics & numerical data; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D059645:Mutation Rate; D011518:Proto-Oncogene Proteins / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; D049308:Dioxygenases; C541081:TET2 protein, human