title: Transfusion-induced hemoglobinopathy in patients of beta-thalassemia major.
abstract: Apparent hemoglobinopathy acquired after blood transfusion is an uncommon cause of diagnostic dilemma resulting in repeated testing and delay in the diagnosis. Out of the 1530 hemoglobin (Hb)-high-performance liquid chromatography (HPLC) performed at our hospital (May 2009 to April 2010), 3 pediatric cases of thalassemia major were detected having posttransfusion hemoglobinopathy with HbS ranging from 9.9% to 18.5%. In all three cases, there was no variant hemoglobin in earlier documented Hb-HPLC. It is important to be aware of and consider apparent transfusion-induced hemoglobinopathy in patients with unusual percentage of variant hemoglobin to avoid unnecessary treatment and counseling.
authors.affiliation: Department of Haematology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India. drskgupta1@gmail.com
authors.forename: Sanjeev K
authors.initials: SK
authors.lastname: Gupta
authors.forename: Monica
authors.initials: M
authors.lastname: Sharma
authors.forename: Seema
authors.initials: S
authors.lastname: Tyagi
authors.forename: Hara P
authors.initials: HP
authors.lastname: Pati
mesh_terms: D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D006453:Hemoglobinopathies / Q000175:diagnosis* / Q000473:pathology*; D006454:Hemoglobins / Q000737:chemistry; D006801:Humans; D007223:Infant; D008297:Male; D065227:Transfusion Reaction; D017086:beta-Thalassemia / Q000150:complications* / Q000628:therapy*
chemical_list: D006454:Hemoglobins