title: Perfusion fraction of diffusion-weighted MRI for predicting the presence of blood supply in ovarian masses.
abstract: OBJECTIVE
  To evaluate whether perfusion fraction (PF) calculated with diffusion-weighted magnetic resonance imaging (MRI) predicts the presence of blood supply in ovarian masses.
  
  
  METHODS
  PFs of 92 ovarian lesions in 53 patients administered gadolinium were retrospectively calculated with diffusion-weighted images at b-values of 0, 500, and 1000 sec/mm(2). PFs were compared between ovarian lesions, except for fat, with (n = 21) or without contrast enhancement (n = 57), using Student's t-test and receiver operating characteristics (ROC) curve analysis. Lesion enhancement rates of contrast-enhanced images at 30 and 180 seconds after gadolinium injection (ER(30sec) and ER(180sec)) and PFs were compared using Pearson's correlation coefficient.
  
  
  RESULTS
  PFs of the lesions with contrast enhancement were significantly higher than those without contrast enhancement (0.22 ± 0.09 and 0.02 ± 0.08, respectively, P < 0.0001). The ROC curve identified the best cutoff point for PF at 0.135 (95.2% sensitivity and 94.7% specificity) as a predictor of the contrast enhancement effect. The area under the ROC curve was 0.984. PF correlated moderately with ER(30sec) (0.62, y = 0.13x + 0.04, P < 0.0001) and ER(180sec) (0.74, y = 0.13x + 0.03, P < 0.0001).
  
  
  CONCLUSIONS
  PF calculated with diffusion-weighted images can potentially predict blood supply in ovarian masses.
authors.affiliation: Department of Radiology, Tokyo Women's Medical University Medical Center East, Tokyo, Japan. i@imodey.com
authors.forename: Satoru
authors.initials: S
authors.lastname: Morita
authors.forename: Shinya
authors.initials: S
authors.lastname: Kojima
authors.forename: Masami
authors.initials: M
authors.lastname: Hirata
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Suzuki
authors.forename: Eiko
authors.initials: E
authors.lastname: Ueno
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media / Q000494:pharmacology; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D005682:Gadolinium / Q000494:pharmacology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000098:blood supply* / Q000175:diagnosis / Q000473:pathology*; D010477:Perfusion; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D005682:Gadolinium