title: Correlation of circulating omentin-1 with bone mineral density in multiple sclerosis: the crosstalk between bone and adipose tissue.
abstract: BACKGROUND
  Patients with multiple sclerosis (MS) are at increased risk of osteoporosis and fractures. Adipose tissue-derived adipokines may play important roles in the osteoimmunology of MS. In order to determine whether omentin-1 and vaspin may be related to bone health in MS patients, we compared circulating levels of these recently identified adipokines, between MS patients and healthy controls.
  
  
  METHODS
  A total of 35 ambulatory MS patients with relapsing-remitting courses were compared with 38 age- and sex-matched healthy controls. Bone mineral density (BMD) was determined for the lumbar spine (L2-L4) and the proximal femur using dual-energy x-ray absorptiometry. Circulating omentin-1, vaspin, osteocalcin, osteopontin, osteoprotegerin, the receptor activator of nuclear factor-κB ligand, matrix metalloproteinase 9, C-reactive protein and 25-hydroxy vitamin D levels were evaluated by highly specific enzyme-linked immunosorbent assay methods.
  
  
  RESULTS
  There was no significant difference between the two groups regarding bone-related cytokines, adipocytokines, and the BMD measurements of patients with MS and the healthy controls. However, in multiple regression analysis, serum omentin-1 levels were positively correlated with BMD at the femoral neck (β = 0.49, p = 0.016), total hip (β = 0.42, p = 0.035), osteopontin (β = 0.42, p = 0.030) and osteocalcin (β = 0.53, p = 0.004) in MS patients. No correlations were found between vaspin, biochemical, and BMD measures in both groups.
  
  
  CONCLUSIONS
  Elevated omentin-1 serum levels are correlated with BMD at the femoral neck and the serum levels of osteocalcin and osteopontin in MS patients. Therefore, there is crosstalk between adipose tissue and bone in MS.
authors.affiliation: The Persian Gulf Nuclear Medicine Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Assadi
authors.forename: Hooman
authors.initials: H
authors.lastname: Salimipour
authors.forename: Samad
authors.initials: S
authors.lastname: Akbarzadeh
authors.forename: Reza
authors.initials: R
authors.lastname: Nemati
authors.forename: Syed Mojtaba
authors.initials: SM
authors.lastname: Jafari
authors.forename: Afshar
authors.initials: A
authors.lastname: Bargahi
authors.forename: Zahra
authors.initials: Z
authors.lastname: Samani
authors.forename: Mohammad
authors.initials: M
authors.lastname: Seyedabadi
authors.forename: Zahra
authors.initials: Z
authors.lastname: Sanjdideh
authors.forename: Iraj
authors.initials: I
authors.lastname: Nabipour
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D005260:Female; D005269:Femur / Q000473:pathology; D058851:GPI-Linked Proteins / Q000097:blood; D005786:Gene Expression Regulation; D006801:Humans; D037102:Lectins / Q000097:blood*; D008297:Male; D009103:Multiple Sclerosis / Q000097:blood*; D011446:Prospective Studies; D012044:Regression Analysis; D012306:Risk; D015843:Serpins / Q000096:biosynthesis
chemical_list: D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins; C507339:SERPINA12 protein, human; D015843:Serpins; D002097:C-Reactive Protein