title: The effect of curcumin in the ectonucleotidases and acetylcholinesterase activities in synaptosomes from the cerebral cortex of cigarette smoke-exposed rats.
abstract: With the evidence that curcumin may be a potent neuroprotective agent and that cigarette smoke is associated with a decline in the cognitive performance as our bases, we investigated the activities of Ecto-Nucleoside Triphosphate Diphosphohydrolase (NTPDase), 5'-nucleotidase and acetylcholinesterase (AChE) in cerebral cortex synaptosomes from cigarette smoke-exposed rats treated with curcumin (Cur). The experimental procedures entailed two sets of experiments. In the first set, the groups were vehicle, Cur 12·5, 25 and 50 mg·kg(-1) ; those in the second set were vehicle, smoke, smoke and Cur 12·5, 25 and 50 mg·kg(-1) . Curcumin prevented the increased NTPDase, 5'-nucleotidase and AChE activities caused by smoke exposure. We suggest that treatment with Cur was protective because the decrease of ATP and acetylcholine (ACh) concentrations is responsible for cognitive impairment, and both ATP and ACh have key roles in neurotransmission.
authors.affiliation: Centro de Ciências Naturais e Exatas, Departamento de Química, Laboratório de Enzimologia Toxicológica, Universidade Federal de Santa Maria, Campus Universitário, Camobi, Brazil. dbitencourtrosaleal@gmail.com
authors.forename: Jeandre Augusto Dos Santos
authors.initials: JA
authors.lastname: Jaques
authors.forename: João Felipe Peres
authors.initials: JF
authors.lastname: Rezer
authors.forename: Jamile Fabbrin
authors.initials: JF
authors.lastname: Gonçalves
authors.forename: Rosélia Maria
authors.initials: RM
authors.lastname: Spanevello
authors.forename: Jessié Martins
authors.initials: JM
authors.lastname: Gutierres
authors.forename: Victor Câmera
authors.initials: VC
authors.lastname: Pimentel
authors.forename: Gustavo Roberto
authors.initials: GR
authors.lastname: Thomé
authors.forename: Vera Maria
authors.initials: VM
authors.lastname: Morsch
authors.forename: Maria Rosa Chitolina
authors.initials: MR
authors.lastname: Schetinger
authors.forename: Daniela Bitencourt Rosa
authors.initials: DB
authors.lastname: Leal
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000201:enzymology*; D003474:Curcumin / Q000008:administration & dosage*; D004781:Environmental Exposure / Q000009:adverse effects*; D004791:Enzyme Inhibitors / Q000008:administration & dosage; D006801:Humans; D008297:Male; D009708:Nucleotidases / Q000037:antagonists & inhibitors / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012906:Smoke / Q000009:adverse effects*; D013574:Synaptosomes / Q000187:drug effects / Q000201:enzymology*; D014026:Nicotiana / Q000009:adverse effects*; D014028:Tobacco Smoke Pollution / Q000009:adverse effects
chemical_list: D004791:Enzyme Inhibitors; D012906:Smoke; D014028:Tobacco Smoke Pollution; D000110:Acetylcholinesterase; D009708:Nucleotidases; C030287:nucleotidase; D000251:Adenosine Triphosphatases; C027201:ectoATPase; D003474:Curcumin