title: ARTreat Project: three-dimensional numerical simulation of plaque formation and development in the arteries.
abstract: Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in arteries. It is characterized by dysfunction of endothelium and vasculitis, and accumulation of lipid, cholesterol, and cell elements inside blood vessel wall. In this study, a continuum-based approach for plaque formation and development in 3-D is presented. The blood flow is simulated by the 3-D Navier-Stokes equations, together with the continuity equation while low-density lipoprotein (LDL) transport in lumen of the vessel is coupled with Kedem-Katchalsky equations. The inflammatory process was solved using three additional reaction-diffusion partial differential equations. Transport of labeled LDL was fitted with our experiment on the rabbit animal model. Matching with histological data for LDL localization was achieved. Also, 3-D model of the straight artery with initial mild constriction of 30% plaque for formation and development is presented.
authors.affiliation: Faculty of Mechanical Engineering, University of Kragujevac, 34000 Kragujevac, Serbia. fica@kg.ac.rs
authors.forename: Nenad
authors.initials: N
authors.lastname: Filipovic
authors.forename: Mirko
authors.initials: M
authors.lastname: Rosic
authors.forename: Irena
authors.initials: I
authors.lastname: Tanaskovic
authors.forename: Zarko
authors.initials: Z
authors.lastname: Milosevic
authors.forename: Dalibor
authors.initials: D
authors.lastname: Nikolic
authors.forename: Nebojsa
authors.initials: N
authors.lastname: Zdravkovic
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Peulic
authors.forename: Milos R
authors.initials: MR
authors.lastname: Kojic
authors.forename: Dimitris I
authors.initials: DI
authors.lastname: Fotiadis
authors.forename: Oberdan
authors.initials: O
authors.lastname: Parodi
mesh_terms: D000465:Algorithms; D000818:Animals; D001783:Blood Flow Velocity; D001794:Blood Pressure; D001809:Blood Viscosity; D003198:Computer Simulation; D021621:Imaging, Three-Dimensional; D008077:Lipoproteins, LDL / Q000378:metabolism; D008955:Models, Cardiovascular; D058226:Plaque, Atherosclerotic / Q000473:pathology* / Q000503:physiopathology; D011817:Rabbits; D013314:Stress, Mechanical
chemical_list: D008077:Lipoproteins, LDL