title: Multicomponent synthesis of artificial nucleases and their RNase and DNase activity.
abstract: The synthesis of new, artificial ribonucleases containing two amino acid residues connected by an aliphatic linker has been developed. Target molecules were synthesized via a catalytic three-component Ugi reaction from aliphatic diisocyanides. Preliminary investigations proved unspecific nuclease activity of the new compounds towards single-stranded RNA and double-stranded circular DNA.
authors.affiliation: Department of Chemistry, Moscow State University, 119992, Leninskie Gory, Moscow, Russia.
authors.forename: Anton V
authors.initials: AV
authors.lastname: Gulevich
authors.forename: Lyudmila S
authors.initials: LS
authors.lastname: Koroleva
authors.forename: Olga V
authors.initials: OV
authors.lastname: Morozova
authors.forename: Valentina N
authors.initials: VN
authors.lastname: Bakhvalova
authors.forename: Vladimir N
authors.initials: VN
authors.lastname: Silnikov
authors.forename: Valentine G
authors.initials: VG
authors.lastname: Nenajdenko