title: Docetaxel-induced nail toxicity: a case of severe onycholysis and topic review.
abstract: Docetaxel is a commonly-used anti-cancer chemotherapeutic agent given its efficacy in a large variety of solid tumors. It is associated with various adverse effects one of which is nail toxicity. We report a case of severe onycholysis as a result of treatment with docetaxel in a patient who suffered from metastatic nasopharyngeal carcinoma. The case report will be followed by a discussion on the possible mechanism and preventive strategies for taxane-induced nail toxicity.
authors.affiliation: Department of Clinical Oncology, Prince of Wales Hospital, Shatin, Ngan Shing Street, New Territories, Hong Kong, China. patricklau75@hotmail.com
authors.forename: Chi-Pan
authors.initials: CP
authors.lastname: Lau
authors.forename: Pun
authors.initials: P
authors.lastname: Hui
authors.forename: Tak-Cheung
authors.initials: TC
authors.lastname: Chan
mesh_terms: D000328:Adult; D000077143:Docetaxel; D005260:Female; D006801:Humans; D009262:Nails / Q000187:drug effects* / Q000473:pathology*; D054039:Onycholysis / Q000139:chemically induced*; D043823:Taxoids / Q000009:adverse effects*
chemical_list: D043823:Taxoids; D000077143:Docetaxel