title: Saitohin and APOE polymorphisms influence cognition and function in persons with advanced Alzheimer Disease.
abstract: OBJECTIVE
  Alzheimer disease (AD) is characterized by variability in the onset and progression of cognitive, functional and behavioral symptoms. The purpose of this study was to identify genetic correlates of symptom variability in persons with moderate-to-advanced AD.
  
  
  METHODS
  Repeated measures of cognition, function and behavior were collected from institutionalized persons with AD over 12 months. Candidate genes were assayed.
  
  
  RESULTS
  Single polymorphisms within the saitohin and APOE genes were associated with increased cognitive impairment and functional dependence. The APOE-ε4 allele was associated with increased baseline physical agitation.
  
  
  CONCLUSIONS
  The development of predictive profiles for the clinical symptoms of AD may increase our ability to identify clinical subgroups for more targeted intervention.
authors.affiliation: Michigan State University College of Nursing, East Lansing, Mich., USA. schutted @ msu.edu
authors.forename: Debra L
authors.initials: DL
authors.lastname: Schutte
authors.forename: David
authors.initials: D
authors.lastname: Reed
authors.forename: Susan
authors.initials: S
authors.lastname: Decrane
authors.forename: Anne L
authors.initials: AL
authors.lastname: Ersig
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications* / Q000235:genetics; D053327:Apolipoprotein E4 / Q000235:genetics*; D003072:Cognition Disorders / Q000150:complications / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012720:Severity of Illness Index; D016875:tau Proteins / Q000235:genetics*
chemical_list: D053327:Apolipoprotein E4; C458340:STH protein, human; D016875:tau Proteins