title: Luminescent ruthenium(II) polypyridyl functionalized gold nanoparticles; their DNA binding abilities and application as cellular imaging agents.
abstract: The synthesis and photophysical and biological investigation of Ru(II)-polypyridyl stabilized water-soluble, luminescent gold nanoparticles (AuNPs) are described. These structures bind to DNA and undergo rapid cellular uptake, being localized within the cell cytoplasm and nucleus within 4 h.
authors.affiliation: School of Chemistry, Centre for Synthesis and Chemical Biology, Trinity College, Dublin, Dublin 2, Ireland.
authors.forename: Robert B P
authors.initials: RB
authors.lastname: Elmes
authors.forename: Kim N
authors.initials: KN
authors.lastname: Orange
authors.forename: Suzanne M
authors.initials: SM
authors.lastname: Cloonan
authors.forename: D Clive
authors.initials: DC
authors.lastname: Williams
authors.forename: Thorfinnur
authors.initials: T
authors.lastname: Gunnlaugsson
mesh_terms: D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D004247:DNA / Q000378:metabolism*; D006046:Gold / Q000032:analysis / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D049449:Luminescence; D049408:Luminescent Agents / Q000032:analysis* / Q000737:chemistry; D018613:Microscopy, Confocal / Q000379:methods; D053758:Nanoparticles / Q000032:analysis* / Q000737:chemistry / Q000648:ultrastructure; D009942:Organometallic Compounds / Q000032:analysis* / Q000737:chemistry; D011725:Pyridines / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism
chemical_list: D049408:Luminescent Agents; D009942:Organometallic Compounds; D011725:Pyridines; D006046:Gold; D004247:DNA