title: Secreted factors from Bifidobacterium animalis subsp. lactis inhibit NF-κB-mediated interleukin-8 gene expression in Caco-2 cells.
abstract: The objective of the present study was to evaluate the anti-inflammatory effects of Bifidobacterium animalis subsp. lactis strain BB12 in stimulated Caco-2 cells and to characterize the factors responsible for these anti-inflammatory effects. Characterization and purification studies indicate that BB12's anti-inflammatory factors might include a 50-kDa proteinaceous compound that is stable under a variety of heat and pH conditions.
authors.affiliation: Department of Biochemistry and Molecular Biology, The Second Clinical Hospital of Jilin University, Changchun 130041, People's Republic of China.
authors.forename: Zhonggui
authors.initials: Z
authors.lastname: Wang
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Cheng
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D001426:Bacterial Proteins / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D001644:Bifidobacterium / Q000378:metabolism*; D018938:Caco-2 Cells; D015870:Gene Expression / Q000187:drug effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D016209:Interleukin-8 / Q000037:antagonists & inhibitors*; D008970:Molecular Weight; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D055550:Protein Stability; D013696:Temperature
chemical_list: D000893:Anti-Inflammatory Agents; D001426:Bacterial Proteins; D016209:Interleukin-8; D016328:NF-kappa B