title: S100-negative indeterminate cell histiocytosis in an African American child responsive to narrowband ultraviolet B.
abstract: Indeterminate cell histiocytosis is a rare cutaneous disease characterized by the presence of dendritic cells that lack Birbeck granules and immunophenotypically shares features of both Langerhans cells and macrophages. We describe a case of a 4-year-old African American boy affected by a disseminated, exclusively mucocutaneous form of indeterminate cell histiocytosis. The eruption was successfully treated with narrowband ultraviolet B. The peculiar negativity of the Langerhans cell marker S100 is also discussed.
authors.affiliation: Department of Dermatology and Cutaneous Surgery, University of Miami, Miller School of Medicine, Miami, Florida 33125, USA. sbard@med.miami.edu
authors.forename: Susan
authors.initials: S
authors.lastname: Bard
authors.forename: Daniele
authors.initials: D
authors.lastname: Torchia
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Connelly
authors.forename: Ana M
authors.initials: AM
authors.lastname: Duarte
authors.forename: Evangelos V
authors.initials: EV
authors.lastname: Badiavas
authors.forename: Lawrence A
authors.initials: LA
authors.lastname: Schachner
mesh_terms: D001741:Black or African American; D002675:Child, Preschool; D015614:Histiocytosis / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D007801:Langerhans Cells / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D009418:S100 Proteins / Q000032:analysis; D014467:Ultraviolet Therapy / Q000379:methods*
chemical_list: D009418:S100 Proteins