title: Genetic causation of neointimal hyperplasia in hemodialysis vascular access dysfunction.
abstract: The major cause of hemodialysis vascular access failure is venous stenosis resulting from neointimal hyperplasia. Genetic factors have been shown to be associated with cardiovascular disease and peripheral vascular disease (PVD) in the general population. Genetic factors may also play an important role in vascular access stenosis and development of neointimal hyperplasia by affecting pathways that lead to inflammation, endothelial function, oxidative stress, and vascular smooth muscle proliferation. This review will discuss the role of genetics in understanding neointimal hyperplasia development in hemodialysis vascular access dysfunction and other disease processes with similar neointimal hyperplasia development such as coronary artery disease and PVD.
authors.affiliation: Department of Internal Medicine, Division of Nephrology and Hypertension, University of Cincinnati, Cincinnati, Ohio 45267-0585, USA. timmy.lee@uc.edu
authors.forename: Timmy
authors.initials: T
authors.lastname: Lee
authors.forename: Davinder
authors.initials: D
authors.lastname: Wadehra
mesh_terms: D001166:Arteriovenous Shunt, Surgical / Q000009:adverse effects* / Q000295:instrumentation; D002408:Catheters, Indwelling / Q000009:adverse effects*; D004868:Equipment Failure; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006965:Hyperplasia / Q000209:etiology / Q000235:genetics / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000628:therapy*; D058426:Neointima / Q000235:genetics / Q000473:pathology*; D018384:Oxidative Stress / Q000235:genetics; D016491:Peripheral Vascular Diseases / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D011110:Polymorphism, Genetic; D012333:RNA, Messenger / Q000235:genetics; D006435:Renal Dialysis / Q000009:adverse effects / Q000379:methods*; D014652:Vascular Diseases
chemical_list: D012333:RNA, Messenger