title: Association of placental volume measured by MRI and birth weight percentile.
abstract: OBJECTIVE
  To investigate if placental volume in the second trimester of pregnancy is related to uterine artery blood flow and neonatal birth weight.
  
  
  METHODS
  In 83 singleton pregnancies at 24-29 weeks' gestation, uterine artery pulsatility index (PI) was measured by Doppler ultrasound and placental volume was calculated from images obtained by magnetic resonance imaging (MRI) at 1.5T. The significance of the association between placental volume, uterine artery PI, and birth weight was examined.
  
  
  RESULTS
  In 37 normal pregnancies resulting in delivery of neonates with birth weight at or above the 10th percentile, the median placental volume increased with gestational age from 363 cm(3) at 24 weeks to 515 cm(3) at 29 weeks. In 46 pregnancies that resulted in delivery of small for gestational age (SGA) neonates with birth weight below the 10th percentile the median placental volume, corrected for gestational age, was significantly decreased by 120 cm(3) (P < 0.0001) and median uterine artery PI was increased (1.87 vs. 1.59, P < 0.0001). There were significant associations between placental volume and both uterine artery PI (r = -0.677, P < 0.0001) and birth weight percentile (r = 0.658, P < 0.0001).
  
  
  CONCLUSIONS
  Placental volume during the second trimester is smaller in pregnancies that subsequently deliver SGA neonates and the measurement is related to placental perfusion.
authors.affiliation: Harris Birthright Research Centre, Kings College Hospital, London, UK.
authors.forename: Iris E
authors.initials: IE
authors.lastname: Derwig
authors.forename: Ranjit
authors.initials: R
authors.lastname: Akolekar
authors.forename: Fernando O
authors.initials: FO
authors.lastname: Zelaya
authors.forename: Penny A
authors.initials: PA
authors.lastname: Gowland
authors.forename: Gareth J
authors.initials: GJ
authors.lastname: Barker
authors.forename: Kypros H
authors.initials: KH
authors.lastname: Nicolaides
mesh_terms: D000328:Adult; D001724:Birth Weight; D001783:Blood Flow Velocity; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis / Q000473:pathology*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015588:Observer Variation; D010920:Placenta / Q000473:pathology*; D011247:Pregnancy; D016216:Ultrasonography, Prenatal / Q000379:methods; D055988:Uterine Artery / Q000473:pathology