title: Fosfomycin: an old--new antibiotic.
abstract: Fosfomycin is a broad-spectrum antibiotic discovered in Spain in 1969. It has bactericidal activity against a wide range of bacteria, including gram-negative micro-organisms and some gram-positive bacteria, such as staphylococci. Initially fosfomycin was administered parenterally and only to patients with severe infections. Today it is often dispensed as fosfomycin-trometamol, an oral formula recommended in the treatment of urinary tract infections. Fosfomycin-trometamol in a single dose is indicated for the treatment of women with uncomplicated urinary tract infections.
authors.affiliation: Infectious Diseases Unit, Ha'Emek Medical Centre, Afula, Israel. raz_r@clalit.org.il
authors.forename: R
authors.initials: R
authors.lastname: Raz
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D005578:Fosfomycin / Q000009:adverse effects / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D005578:Fosfomycin