title: Dietary hydroxypropyl methylcellulose increases excretion of saturated and trans fats by hamsters fed fast food diets.
abstract: In animal studies, hydroxypropyl methylcellulose (HPMC) intake results in increased fecal fat excretion; however, the effects on dietary saturated fatty acids (SATs) and trans-fatty acids (TRANS) remain unknown. This study investigated the effect of HPMC on digestion and absorption of lipids in male Golden Syrian hamsters fed either freeze-dried ground pizza (PZ), pound cake (PC), or hamburger and fries (BF) supplemented with dietary fiber from either HPMC or microcrystalline cellulose (MCC) for 3 weeks. We observed greater excretion of SATs and TRANS by both diets supplemented with HPMC or MCC as compared to the feed. SAT, TRANS, and unsaturated fatty acids (UNSAT) contents of feces of the PZ diet supplemented with HPMC were 5-8 times higher than diets supplemented with MCC and tended to be higher in the PC- and BF-HPMC supplemented diets as well. We also observed significant increases in fecal excretion of bile acids (2.6-3-fold; P < 0.05), sterols (1.1-1.5-fold; P < 0.05), and unsaturated fatty acids (UNSAT, 1.7-4.5-fold; P < 0.05). The animal body weight gain was inversely correlated with the excretion of fecal lipid concentrations of bile acids (r = -0.56; P < 0.005), sterols (r = -0.48; P < 0.005), SAT (r = -0.69; P < 0.005), UNSAT (r = -0.67; P < 0.005), and TRANS (r = -0.62; P < 0.005). Therefore, HPMC may be facilitating fat excretion in a biased manner with preferential fecal excretion of both TRANS and SAT in hamsters fed fast food diets.
authors.affiliation: Processed Foods Research, Western Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, Albany, California 94710, United States.
authors.forename: Wallace
authors.initials: W
authors.lastname: Yokoyama
authors.forename: William H K
authors.initials: WH
authors.lastname: Anderson
authors.forename: David R
authors.initials: DR
authors.lastname: Albers
authors.forename: Yun-Jeong
authors.initials: YJ
authors.lastname: Hong
authors.forename: Marsha L
authors.initials: ML
authors.lastname: Langhorst
authors.forename: Shao-Ching
authors.initials: SC
authors.lastname: Hung
authors.forename: Jiann-Tsyh
authors.initials: JT
authors.lastname: Lin
authors.forename: Scott A
authors.initials: SA
authors.lastname: Young
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000032:analysis; D006224:Cricetinae; D004032:Diet / Q000662:veterinary*; D004041:Dietary Fats / Q000493:pharmacokinetics*; D004043:Dietary Fiber; D057140:Fast Foods; D005227:Fatty Acids / Q000032:analysis / Q000493:pharmacokinetics*; D005231:Fatty Acids, Unsaturated / Q000032:analysis; D005243:Feces / Q000737:chemistry; D065347:Hypromellose Derivatives; D008297:Male; D008647:Mesocricetus; D008747:Methylcellulose / Q000008:administration & dosage / Q000031:analogs & derivatives*; D013261:Sterols / Q000032:analysis; D044242:Trans Fatty Acids / Q000032:analysis / Q000493:pharmacokinetics*
chemical_list: D001647:Bile Acids and Salts; D004041:Dietary Fats; D004043:Dietary Fiber; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D013261:Sterols; D044242:Trans Fatty Acids; D065347:Hypromellose Derivatives; D008747:Methylcellulose