title: Comparison of different ovarian cancer detection algorithms.
abstract: The objective of the study was to evaluate the accuracy of a combined-two step ovarian cancer screening tool consisting of the ovarian cancer symptom index combined with either a risk of ovarian malignancy algorithm (ROMA) or a risk of malignancy index.
  
  
  METHODS
  The case-control study consisted of 31 patients with ovarian cancer, 30 patients with benign ovarian diseases and 27 age-matched healthy controls.
  
  
  RESULTS
  Sensitivity and specificity of the ovarian cancer symptom index among menopausal women were 84.6% and 52.9%, respectively. ROMA revealed the highest discriminative value when compared to others (AUC 98.4%). When the cutoff level of 28 was applied for menopausal women, ROMA revealed sensitivity and specificity of 95.8% and 93.1%, respectively.
  
  
  CONCLUSIONS
  The ovarian cancer symptom index could be used as the first step in ovarian cancer screening with subsequent application of ROMA as a second step screening tool. A larger sample size in both control and patient groups should be evaluated to reach clear conclusions.
authors.affiliation: Riga Stradins University, A. Kirhenstein's Institute of Microbiology and Virology, Riga, Latvia. r.macuks@gmail.com
authors.forename: R
authors.initials: R
authors.lastname: Macuks
authors.forename: I
authors.initials: I
authors.lastname: Baidekalna
authors.forename: S
authors.initials: S
authors.lastname: Donina
mesh_terms: D000465:Algorithms; D014408:Biomarkers, Tumor / Q000032:analysis; D018394:CA-125 Antigen / Q000032:analysis*; D016022:Case-Control Studies; D055088:Early Detection of Cancer; D030501:Epididymal Secretory Proteins / Q000032:analysis*; D005260:Female; D006801:Humans; D007844:Latvia; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D012680:Sensitivity and Specificity; D023083:beta-Defensins
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; C426184:DEFB126 protein, human; D030501:Epididymal Secretory Proteins; D023083:beta-Defensins