title: Multifunctional, biocompatible supramolecular hydrogelators consist only of nucleobase, amino acid, and glycoside.
abstract: The integration of nucleobase, amino acid, and glycoside into a single molecule results in a novel class of supramolecular hydrogelators, which not only exhibit biocompatibility and biostability but also facilitate the entry of nucleic acids into cytosol and nuclei of cells. This work illustrates a simple way to generate an unprecedented molecular architecture from the basic biological building blocks for the development of sophisticated soft nanomaterials, including supramolecular hydrogels.
authors.affiliation: Department of Chemistry, Brandeis University, Waltham, Massachusetts 02454, USA.
authors.forename: Xinming
authors.initials: X
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Kuang
authors.forename: Junfeng
authors.initials: J
authors.lastname: Shi
authors.forename: Yuan
authors.initials: Y
authors.lastname: Gao
authors.forename: Hsin-Chieh
authors.initials: HC
authors.lastname: Lin
authors.forename: Bing
authors.initials: B
authors.lastname: Xu
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D002470:Cell Survival; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry*; D046911:Macromolecular Substances / Q000138:chemical synthesis / Q000737:chemistry; D009711:Nucleotides / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D001672:Biocompatible Materials; D004337:Drug Carriers; D006027:Glycosides; D020100:Hydrogels; D046911:Macromolecular Substances; D009711:Nucleotides