title: Bioreducible micelles and hydrogels with tunable properties from multi-armed biodegradable copolymers.
abstract: Multi-armed biodegradable block copolymers with a bioreducible core mPCL-b-PEO were for the first time synthesized by thiol-yne click chemistry. They self-assembled into bioreducible micelles and hydrogels in aqueous solution, which demonstrated tunable size, mechanical and drug-release properties.
authors.affiliation: School of Chemistry & Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, PR China.
authors.forename: Lin
authors.initials: L
authors.lastname: Sun
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Chang-Ming
authors.initials: CM
authors.lastname: Dong
mesh_terms: D004317:Doxorubicin / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry / Q000378:metabolism; D020100:Hydrogels / Q000737:chemistry* / Q000378:metabolism*; D008823:Micelles; D010084:Oxidation-Reduction; D011091:Polyesters / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D004337:Drug Carriers; D020100:Hydrogels; D008823:Micelles; D011091:Polyesters; C458722:polyethylene oxide-polycaprolactone copolymer; D004317:Doxorubicin