title: The role of KSRP in mRNA decay and microRNA precursor maturation.
abstract: KH-type splicing regulatory protein (KSRP)/FBP2, a single-strand nucleic acid binding protein originally identified as both an RNA-binding protein and a transcription factor, affects RNA fates at multiple levels. In this review we will discuss the ability of KSRP to (1) promote decay of labile mRNAs by interacting with some components of the mRNA decay machinery and (2) favor the maturation of a select group of microRNA precursors. We also discuss how its peculiar modular structure allows KSRP to specifically interact with a wide spectrum of RNA sequences and how post-translational modifications influence KSRP functions in cell proliferation and differentiation.
authors.affiliation: Istituto Nazionale per la Ricerca sul Cancro (IST), 16132 Genova, Italy. rgherzi@ucsd.edu
authors.forename: Roberto
authors.initials: R
authors.lastname: Gherzi
authors.forename: Ching-Yi
authors.initials: CY
authors.lastname: Chen
authors.forename: Michele
authors.initials: M
authors.lastname: Trabucchi
authors.forename: Andres
authors.initials: A
authors.lastname: Ramos
authors.forename: Paola
authors.initials: P
authors.lastname: Briata
mesh_terms: D000818:Animals; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D012322:RNA Precursors / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional / Q000235:genetics*; D020871:RNA Stability / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
chemical_list: C105789:KHSRP protein, human; D035683:MicroRNAs; D012322:RNA Precursors; D016601:RNA-Binding Proteins; D015534:Trans-Activators