title: [Collagenase Clostridum histolyticum in the management of Dupuytren's contracture].
abstract: Dupuytren's contracture is a fibroproliferate disease of the palmar aponeurosis with a formation of nodules and cords. Surgical treatment is the gold standard for Dupuytren's contracture at the moment. A short while ago Collagenase clostridium histolyticum was licensed as a non-surgical method to treat Dupuytren's contracture. Collagenase clostridium histolyticum is injected directly into the Dupuytren's cord and after 24 h the contracture is distended by manual rupturing. Collagenase clostridium histolyticum causes a depletion of collagen, however neurovascular structures are spared. 2 clinical phase III studies showed that contractures could be effectively reduced when using Collagenase clostridium histolyticum. However, there are no long-term results regarding effectiveness and side effects, or comparative studies using surgical methods. This paper presents a review of Collagenase clostridium histolyticum and its role in the management of Dupuytren's contracture. Indication, technical procedure, treatment results and complications are described.
authors.affiliation: Deutsch-Ordens-Spital Friesach, Abteilung für Chirurgie, St. Veiter Strasse 12, Friesach, Austria. lukasholzer@gmail.com
authors.forename: L A
authors.initials: LA
authors.lastname: Holzer
authors.forename: G
authors.initials: G
authors.lastname: Holzer
mesh_terms: D000818:Animals; D017326:Clinical Trials, Phase III as Topic; D047009:Hathewaya histolytica / Q000201:enzymology; D004387:Dupuytren Contracture / Q000097:blood / Q000188:drug therapy*; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D008297:Male; D008657:Metabolic Clearance Rate / Q000502:physiology; D003012:Microbial Collagenase / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D010411:Penile Induration / Q000097:blood / Q000188:drug therapy; D051381:Rats; D012008:Recurrence; D019233:Retreatment
chemical_list: D003012:Microbial Collagenase