title: [Urgency after successful treatment of prostate cancer. Prospective study on the influence of treatment modality, morbidity, and epidemiological factors on the quality of life].
abstract: BACKGROUND
  The aim of this prospective study was to investigate factors influencing long-term health-related quality of life (HRQoL) in patients treated for prostate cancer with no signs of tumor relapse.
  
  
  METHODS
  We included epidemiological and oncological data as well as standardized questionnaires on incontinence and sexual function. Data were analyzed using standard descriptive and explorative statistics.
  
  
  RESULTS
  We obtained pre-therapeutic data as well as a complete data set after 36 months for 488 patients. A total of 162 patients (33.2%) in whom we could not exclude a tumor relapse according to the guidelines of the EAU or because of incomplete data were excluded from further analysis. In a univariate analysis as expected stress incontinence, lower urinary tract symptoms (LUTS), overactive bladder (OAB), urgency, pad use, sexual activity as well as perceived pre-therapeutic HRQoL, being privately insured, and a better school education were significantly associated with post-therapeutic long-term HRQoL (p<0.05). In a multivariate analysis of covariance only dry OAB (p=0.0411) and sexual activity (p=0.0046) proved to be independent parameters with a significant impact on HRQoL after 36 months.
  
  
  CONCLUSIONS
  Symptoms of OAB even without urine loss after successful treatment of prostate cancer need to be addressed in clinical practice as well as in research studies.
authors.affiliation: Kontinenzzentrum, Urologische Klinik, RWTH, Universitätsklinikum Aachen, Pauwelsstraße 30, Aachen, Germany. ruthkirsch@aol.com
authors.forename: R
authors.initials: R
authors.lastname: Kirschner-Hermanns
authors.forename: T
authors.initials: T
authors.lastname: Klementz
authors.forename: A
authors.initials: A
authors.lastname: Haselhuhn
authors.forename: G
authors.initials: G
authors.lastname: Jakse
authors.forename: A
authors.initials: A
authors.lastname: Heidenreich
authors.forename: B
authors.initials: B
authors.lastname: Brehmer
mesh_terms: D000368:Aged; D015897:Comorbidity; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D011788:Quality of Life; D018570:Risk Assessment; D012307:Risk Factors; D012735:Sexual Dysfunction, Physiological / Q000175:diagnosis / Q000453:epidemiology*; D016896:Treatment Outcome; D014549:Urinary Incontinence / Q000175:diagnosis / Q000453:epidemiology*