title: Spectral domain OCT and autofluorescence imaging of unilateral acute idiopathic maculopathy.
abstract: OBJECTIVE
  To report imaging findings of unilateral acute idiopathic maculopathy (UAIM).
  
  
  METHODS
  In this observational case report, the Spectralis acquisition system (Heidelberg Engineering, Germany), which includes spectral domain optical coherence tomography (OCT), multiple autofluorescence (AF), fluorescein angiography (FA), and indocyanine green (ICG) angiography, was used for monitoring onset and evolution of UAIM.
  
  
  RESULTS
  A well-defined, bullous macular lesion was evident on color pictures, infrared imaging (IR), and AF. Fluorescein angiography and ICG similarly showed early hypofluorescence of the lesion and, exclusively on FA, mild staining. Notably, the definition and limits of the detachment were clearly identifiable on late-phase ICG, and formed a hypocyanescent area. Spectral domain OCT disclosed severe retinal pigment epithelium (RPE) but not neurosensory detachment; the distinction between the photoreceptors inner/outer segment line was nonapparent for the entire length of the lesion. At 7-week follow-up, visual acuity improved to 20/20, with resolution of the exudative detachment. Autofluorescence and FA imaging indicated normalization, and only IR showed the boundaries of the lesion as still identifiable. Infrared imaging also showed a central granular feature, suggesting persistent choroid and pigment alteration. Indocyanine green angiography still evidenced the early hypofluorescent halo that became more evident in the late phases without any staining of the dye. Tomography depicted a reconstituted fovea, in which the outer limiting membrane and the inner/outer segment junction returned detectable.
  
  
  CONCLUSIONS
  Comprehensive evaluation of UAIM by AF, FA, ICG, and spectral domain OCT disclosed involvement of RPE, the neuroretina, and the choroid in the pathogenesis of the disease. Despite functional recovery, choroidal rather than retinal alteration could persist.
authors.affiliation: Ospedale Fatebenefratelli-Oftalmico, Milan, Italy. dottpaolomilani@hotmail.com
authors.forename: Paolo
authors.initials: P
authors.lastname: Milani
authors.forename: Viviana
authors.initials: V
authors.lastname: Cacioppo
authors.forename: Giulia
authors.initials: G
authors.lastname: Raimondi
authors.forename: Antonio
authors.initials: A
authors.lastname: Scialdone
mesh_terms: D000208:Acute Disease; D000328:Adult; D002829:Choroid / Q000473:pathology*; D004396:Coloring Agents; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D012164:Retinal Diseases / Q000175:diagnosis*; D055213:Retinal Pigment Epithelium / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green