title: Genetic predictors of antipsychotic-induced weight gain: a case-matched multi-gene study.
abstract: OBJECTIVE
  To determine associations between weight gain induced by antipsychotic and the polymorphisms of HTR2C gene -759C/T and -697G/C, histamine-1 receptor gene, leptine gene -2548G/A, and adiponectin gene +276G/T and +45T/G.
  
  
  METHODS
  In the case-matched study, 85 patients who gained more than 7% of their pre-drug body weight served as the study group and another 85 patients who gained less than 7% of their pre-drug body weight served as the control group. The ligation diction reaction technique was used to analyze the frequencies of the -759C/T and -697G/C polymorphism of the HTR2C gene, -2548A/G polymorphism of leptin gene, +276G/T and +45T/G polymorphism of adiponectin gene and glu349asp polymorphism of H1 receptor gene.
  
  
  RESULTS
  The presence of the -759C allele, -697G allele, -2548A allele and +276G allele was significantly higher in the study group than that in the control group (P<0.05).
  
  
  CONCLUSIONS
  The -759C/T and -697G/C polymorphisms of the promoter region of 5HT(2)C receptor gene, -2548A/G polymorphisms of leptin gene and +276G/T polymorphisms of adiponectin gene may be associated with the antipsychotic induced weight gain. The glu349asp polymorphisms of histamine-1 receptor gene is not associated with antipsychotic induced weight gain.
authors.affiliation: Central South University, Changsha, China.
authors.forename: Renrong
authors.initials: R
authors.lastname: Wu
authors.forename: Jingping
authors.initials: J
authors.lastname: Zhao
authors.forename: Ping
authors.initials: P
authors.lastname: Shao
authors.forename: Jianjun
authors.initials: J
authors.lastname: Ou
authors.forename: Maihui
authors.initials: M
authors.lastname: Chang
mesh_terms: D052242:Adiponectin / Q000235:genetics; D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020738:Leptin / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D044405:Receptor, Serotonin, 5-HT2C / Q000235:genetics*; D012559:Schizophrenia / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D015430:Weight Gain / Q000187:drug effects / Q000235:genetics*; D055815:Young Adult
chemical_list: D052242:Adiponectin; D014150:Antipsychotic Agents; D020738:Leptin; D044405:Receptor, Serotonin, 5-HT2C