title: Italian pediatric data support hypothesis that simultaneous epidemics of type 1 diabetes and type 2 diabetes/metabolic syndrome/obesity are polar opposite responses (i.e., symptoms) to a primary inflammatory condition.
abstract: We previously postulated that iatrogenic inflammation caused epidemics of type 2 diabetes/metabolic syndrome/obesity by activating an immune suppressive cortisol response which protects against type 1 diabetes and other autoimmune diseases. In the current study, data on the incidence of obesity in different Italian provinces was compared with the incidence of type 1 diabetes in the same region. The association between obesity and type 1 diabetes was analyzed using Wilcoxon rank analysis. Results showed an inverse relationship; the regions with the highest rate of obesity (Campania and Lazia) were associated with a protective effect against type 1 diabetes. However, regions with the lowest rates of obesity were associated with the highest rate of type 1 diabetes. These results are consistent with previous analysis across different racial groups; races with high cortisol activity had an increased rate of type 2 diabetes but were protected from type 1 diabetes.
authors.affiliation: Classen Immunotherapies, Inc., 6517 Montrose Avenue, Baltimore, MD 21212, USA. classen@vaccines.net
authors.forename: John B
authors.initials: JB
authors.lastname: Classen
mesh_terms: D000293:Adolescent; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology* / Q000276:immunology; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000276:immunology; D058872:Epidemics; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000276:immunology; D009765:Obesity / Q000453:epidemiology* / Q000276:immunology; D015995:Prevalence; D012306:Risk; D018709:Statistics, Nonparametric