title: Hepatoid adenocarcinoma of the gallbladder.
abstract: Hepatoid adenocarcinoma is a rare variant of extrahepatic adenocarcinoma which behaves like hepatocellular carcinoma in morphology and functionality. We present a rare case of hepatoid adenocarcinoma of the gallbladder which invades deeply the liver bed, in a 59-year-old woman. Histologically, most of the mass in the gallbladder was composed of cells with eosinophilic cytoplasm arranged in a trabecular pattern, which resembled hepatocellular carcinoma. The main differential diagnosis was hepatocellular carcinoma with invasion into the gallbladder. The gallbladder origin of the hepatoid adenocarcinoma was verified by the presence of foci of conventional adenocarcinoma, the recognition of high-grade dysplasia in the adjacent epithelium and the absence of cirrhosis.
authors.affiliation: Department of Pathology, Habib Bourguiba Hospital, road El Ain., 3029, Sfax, Tunisia. samehktari@yahoo.fr
authors.forename: Sameh
authors.initials: S
authors.lastname: Ellouze
authors.forename: Charfi
authors.initials: C
authors.lastname: Slim
authors.forename: Guirat
authors.initials: G
authors.lastname: Ahmad
authors.forename: Gouiaa
authors.initials: G
authors.lastname: Naourez
authors.forename: Amouri
authors.initials: A
authors.lastname: Ali
authors.forename: Mnif
authors.initials: M
authors.lastname: Héla
authors.forename: Kossentini
authors.initials: K
authors.lastname: Mariem
authors.forename: Ben Amar
authors.initials: BA
authors.lastname: Mohamed
authors.forename: Boudawara
authors.initials: B
authors.lastname: Tahia
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000601:surgery; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D005706:Gallbladder Neoplasms / Q000175:diagnosis* / Q000601:surgery; D006498:Hepatectomy; D006801:Humans; D008875:Middle Aged; D014057:Tomography, X-Ray Computed