title: Beyond the frog: the evolution of homology models of human IKKβ.
abstract: Nuclear Factor κ B is implicated in tumor progression and chronic inflammatory diseases and is regulated by IκB kinase β (IKKβ). The crystal structure of IKKβ has been recently solved for Xenopus laevis. Homology models of human IKKβ have been developed prior to and after the crystal structure was solved. Here, we compare four models of human IKKβ and evaluate their performance in both broad and focused library docking studies.
authors.affiliation: Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, NE 68198, USA.
authors.forename: Nicholas Y
authors.initials: NY
authors.lastname: Palermo
authors.forename: Amarnath
authors.initials: A
authors.lastname: Natarajan
mesh_terms: D000818:Animals; D001665:Binding Sites; D006801:Humans; D051550:I-kappa B Kinase / Q000737:chemistry*; D008958:Models, Molecular; D011487:Protein Conformation; D040681:Structural Homology, Protein
chemical_list: D051550:I-kappa B Kinase