title: Associations of amylin with inflammatory markers and metabolic syndrome in apparently healthy Chinese.
abstract: BACKGROUND
  Cellular and animal studies implicate multiple roles of amylin in regulating insulin action, glucose and lipid metabolisms. However, the role of amylin in obesity related metabolic disorders has not been thoroughly investigated in humans. Therefore, we aimed to evaluate the distribution of circulating amylin and its association with metabolic syndrome (MetS) and explore if this association is influenced by obesity, inflammatory markers or insulin resistance in apparently healthy Chinese.
  
  
  METHODS
  A population-based sample of 1,011 Chinese men and women aged 35-54 years was employed to measure plasma amylin, inflammatory markers (C-reactive protein [CRP] and interleukin-6 [IL-6]), insulin, glucose and lipid profiles. MetS was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian-Americans.
  
  
  RESULTS
  Plasma amylin concentrations were higher in overweight/obese participants than normal-weight counterparts (P<0.001) without sex difference. Circulating amylin was positively associated with CRP, IL-6, BMI, waist circumference, blood pressure, fasting glucose, insulin, amylin/insulin ratio, HOMA-IR, LDL cholesterol and triglycerides, while negatively associated with HDL cholesterol (all P<0.001). After multiple adjustments, the risk of MetS was significantly higher (odds ratio 3.71; 95% confidence interval: 2.53 to 5.46) comparing the highest with the lowest amylin quartile. The association remained significant even further controlling for BMI, inflammatory markers, insulin or HOMA-IR.
  
  
  CONCLUSIONS
  Our study suggests that amylin is strongly associated with inflammatory markers and MetS. The amylin-MetS association is independent of established risk factors of MetS, including obesity, inflammatory markers and insulin resistance. The causal role of hyperamylinemia in the development of MetS needs to be confirmed prospectively.
authors.affiliation: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China.
authors.forename: Xinwei
authors.initials: X
authors.lastname: Hou
authors.forename: Liang
authors.initials: L
authors.lastname: Sun
authors.forename: Zongmeng
authors.initials: Z
authors.lastname: Li
authors.forename: Haiwei
authors.initials: H
authors.lastname: Mou
authors.forename: Zhijie
authors.initials: Z
authors.lastname: Yu
authors.forename: Huaixing
authors.initials: H
authors.lastname: Li
authors.forename: Peizhen
authors.initials: P
authors.lastname: Jiang
authors.forename: Danxia
authors.initials: D
authors.lastname: Yu
authors.forename: Hongyu
authors.initials: H
authors.lastname: Wu
authors.forename: Xingwang
authors.initials: X
authors.lastname: Ye
authors.forename: Xu
authors.initials: X
authors.lastname: Lin
authors.forename: Yingying
authors.initials: Y
authors.lastname: Le
mesh_terms: D000328:Adult; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000378:metabolism*; D007328:Insulin / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D058228:Islet Amyloid Polypeptide / Q000097:blood*; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000378:metabolism*; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000378:metabolism; D050177:Overweight / Q000097:blood / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D007328:Insulin; D015850:Interleukin-6; D058228:Islet Amyloid Polypeptide; D008055:Lipids; D002097:C-Reactive Protein