title: Prestorage leukoreduction abrogates the detrimental effect of aging on packed red cells transfused after trauma: a prospective cohort study.
abstract: BACKGROUND
  The aim of this study was to prospectively duplicate previous retrospective findings showing that prestorage leukoreduction blunts the detrimental effect of aging on banked packed red blood cells transfused after injury.
  
  
  METHODS
  Over 19 months, trauma patients transfused with ≥4 U of packed red blood cells and surviving ≥24 hours were followed. The age of each unit was collected.
  
  
  RESULTS
  The cohort consisted of 153 patients. All models showed no association between advancing blood age and the likelihood of developing multiple-organ dysfunction syndrome or infections, regardless of whether the mean age of blood was analyzed as a continuous variable, as a percentage of blood received that was <14 days old, or as a dichotomized value >14 or <14 days old.
  
  
  CONCLUSIONS
  This prospective study duplicates previous retrospective findings of an abrogation of the detrimental effects of advancing mean packed red blood cell age on outcomes after trauma by performing prestorage leukoreduction.
authors.affiliation: Department of Surgery, Division of Burns/Trauma/Critical Care, University of Texas Southwestern Medical School, Dallas, USA. herb.phelan@utsouthwestern.edu
authors.forename: Herb A
authors.initials: HA
authors.lastname: Phelan
authors.forename: Alexander L
authors.initials: AL
authors.lastname: Eastman
authors.forename: Kim
authors.initials: K
authors.lastname: Aldy
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Carroll
authors.forename: Paul A
authors.initials: PA
authors.lastname: Nakonezny
authors.forename: Tiffany
authors.initials: T
authors.lastname: Jan
authors.forename: Jessi L
authors.initials: JL
authors.lastname: Howard
authors.forename: Yixiao
authors.initials: Y
authors.lastname: Chen
authors.forename: Randall S
authors.initials: RS
authors.lastname: Friese
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Minei
mesh_terms: D000328:Adult; D001424:Bacterial Infections / Q000209:etiology / Q000517:prevention & control*; D001771:Blood Banks; D001800:Blood Specimen Collection; D004905:Erythrocyte Aging; D017707:Erythrocyte Transfusion / Q000379:methods*; D004912:Erythrocytes / Q000502:physiology*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D047589:Leukocyte Reduction Procedures; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology / Q000517:prevention & control*; D011446:Prospective Studies; D014947:Wounds and Injuries / Q000150:complications / Q000628:therapy*