title: Specific absorbed fractions in thyroid diagnostics and treatment: Monte Carlo calculation with PENELOPE.
abstract: In nuclear medicine, diagnostic and therapy procedures in which a certain radiopharmaceutical is administered to a patient are performed. An important point is the determination of the dose absorbed by the important organs of the patient due to these procedures. This dose depends on the particular radionuclide used and the so-called specific absorbed fractions. In this work, by means of Monte Carlo (MC) simulation, the specific absorbed fractions in case the thyroid gland acts as a source organ and for photon energies between 30 keV and 2 MeV have been determined. The computer code PENELOPE has been used as well as the adult male mathematical phantom provided with the distribution of this code. Three different simulation types were carried out. In one of them, only photon transport was considered. In the other two, electron transport was included, doing a detailed and a mixed simulation. In general, the fractions were estimated with uncertainties <9 %, for the mixed and detailed simulations, and <3 %, for the simulation in which only photons are included. For some target organs and, especially for energies <100 keV, the uncertainties found were larger. The results obtained here have been compared with those obtained by other authors using other MC codes. A good agreement has been found in 80 % of the cases.
authors.affiliation: Departamento de Física Atómica, Molecular y Nuclear, Universidad de Granada, E-18071 Granada, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Díaz Londoño
authors.forename: A M
authors.initials: AM
authors.lastname: Lallena
mesh_terms: D003198:Computer Simulation; D019583:Dose Fractionation, Radiation; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D009010:Monte Carlo Method; D017785:Photons / Q000627:therapeutic use; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D012984:Software; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy*