title: Cellular pathology within the anterior cingulate cortex of patients with late-life depression: a morphometric study.
abstract: Previous imaging and morphometric studies have identified volumetric and cellular abnormalities in prefrontal areas in late-life depression. This study aimed to examine cellular morphology using stereological methodology in the supragenual region of the anterior cingulate cortex in late-life depressed patients compared with age-matched controls. Post-mortem tissue was acquired from nine patients with depression and 11 control patients and analyzed using the optical disector and nucleator methods. No changes were found in glial, non-pyramidal and pyramidal cell density, or in non-pyramidal or pyramidal cell volume within individual layers (2-5) or the supragenual anterior cortex as a whole. This study, therefore, does not provide further evidence for cellular abnormalities in late-life depression.
authors.affiliation: Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK. ahmad.khundakar@newcatle.ac.uk
authors.forename: Ahmad Adam
authors.initials: AA
authors.lastname: Khundakar
authors.forename: Christopher Miles
authors.initials: CM
authors.lastname: Morris
authors.forename: Arthur Ernest
authors.initials: AE
authors.lastname: Oakley
authors.forename: Alan Jeffrey
authors.initials: AJ
authors.lastname: Thomas
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002452:Cell Count; D003863:Depression / Q000473:pathology*; D005260:Female; D006179:Gyrus Cinguli / Q000166:cytology / Q000473:pathology*; D006801:Humans; D008297:Male; D009457:Neuroglia / Q000473:pathology*; D009474:Neurons / Q000473:pathology*; D011180:Postmortem Changes; D013238:Stereotaxic Techniques