title: Cardiac magnetic resonance imaging parameters as surrogate endpoints in clinical trials of acute myocardial infarction.
abstract: Cardiac magnetic resonance (CMR) offers a variety of parameters potentially suited as surrogate endpoints in clinical trials of acute myocardial infarction such as infarct size, myocardial salvage, microvascular obstruction or left ventricular volumes and ejection fraction. The present article reviews each of these parameters with regard to the pathophysiological basis, practical aspects, validity, reliability and its relative value (strengths and limitations) as compared to competitive modalities. Randomized controlled trials of acute myocardial infarction which have used CMR parameters as a primary endpoint are presented.
authors.affiliation: University of Leipzig - Heart Center, Department of Internal Medicine/Cardiology, Leipzig, Germany. stdesch@web.de
authors.forename: Steffen
authors.initials: S
authors.lastname: Desch
authors.forename: Ingo
authors.initials: I
authors.lastname: Eitel
authors.forename: Suzanne
authors.initials: S
authors.lastname: de Waha
authors.forename: Georg
authors.initials: G
authors.lastname: Fuernau
authors.forename: Philipp
authors.initials: P
authors.lastname: Lurz
authors.forename: Matthias
authors.initials: M
authors.lastname: Gutberlet
authors.forename: Gerhard
authors.initials: G
authors.lastname: Schuler
authors.forename: Holger
authors.initials: H
authors.lastname: Thiele
mesh_terms: D015415:Biomarkers; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009203:Myocardial Infarction / Q000175:diagnosis*; D016032:Randomized Controlled Trials as Topic; D015203:Reproducibility of Results; D016277:Ventricular Function, Left
chemical_list: D015415:Biomarkers