title: Significance of tumor-infiltrating immune cells in spontaneous canine mammary gland tumor: 140 cases.
abstract: The numbers of tumor infiltrating T lymphocytes, B lymphocytes and antigen presenting cells were evaluated in an immunohistochemical manner in 140 canine spontaneous mammary gland tumor (MGT) tissues. As a result, we found a statistically significant increase in the number of intratumoral T lymphocytes (23.2 ± 23.8) in the malignant MGT group (n=51) compared with the benign MGT group (14.0 ± 16.0, n=89; P<0.05). Moreover, the high T lymphocyte infiltration in the malignant group correlated with poor prognosis in multivariate analysis (P<0.05). This study indicated the relationship between increased infiltrating T lymphocytes and canine MGT malignancy.
authors.affiliation: Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113–8657, Japan.
authors.forename: Kohei
authors.initials: K
authors.lastname: Saeki
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Endo
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Uchida
authors.forename: Ryohei
authors.initials: R
authors.lastname: Nishimura
authors.forename: Nobuo
authors.initials: N
authors.lastname: Sasaki
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nakagawa
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D016009:Chi-Square Distribution; D004283:Dog Diseases / Q000276:immunology* / Q000601:surgery; D004285:Dogs; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D053208:Kaplan-Meier Estimate; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology*; D015674:Mammary Neoplasms, Animal / Q000276:immunology* / Q000601:surgery