title: Innate and adaptive immunity in inflammatory bowel disease.
abstract: Inflammatory bowel diseases are the consequence of a dysregulated mucosal immune system. The mucosal immune system consists of two arms, innate and adaptive immunity, that have been studied separately for a long time. Functional studies from in vivo models of intestinal inflammation as well as results from genome-wide association studies strongly suggest a cross-regulation of both arms. The present review will illustrate this interaction by selecting examples from innate immunity and adaptive immunity, and their direct impact on each other. Broadening our view by focusing on the cross-regulated areas of the mucosal immune system will not only facilitate our understanding of disease, but furthermore will allow identification of future therapeutic targets.
authors.affiliation: Medical Department I (Gastroenterology/Rheumatology/Infectious Diseases), Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, Hindenburgdamm 30, 12203 Berlin, Germany. britta.siegmund@charite.de
authors.forename: Britta
authors.initials: B
authors.lastname: Siegmund
authors.forename: Martin
authors.initials: M
authors.lastname: Zeitz
mesh_terms: D056704:Adaptive Immunity; D000483:Alleles; D000818:Animals; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D007107:Immune System; D007113:Immunity, Innate; D015212:Inflammatory Bowel Diseases / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D018664:Interleukin-12 / Q000378:metabolism; D053759:Interleukin-23 / Q000378:metabolism; D051379:Mice; D008954:Models, Biological; D053473:Nod2 Signaling Adaptor Protein / Q000378:metabolism; D018417:Th1 Cells / Q000166:cytology
chemical_list: D053759:Interleukin-23; C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein; D018664:Interleukin-12