title: [A case of neonatal meningitis due to Listeria monocytogenes serotype 1/2b].
abstract: Listeria monocytogenes, although an uncommon cause of illness in the general population, is an important pathogen in pregnants, neonates, elderly and immunocompromised patients. Neonatal listeriosis is classified as early (< 5 days) and late (? 5 days) according to the onset of the symptoms and findings of the infection. The most encountered serotypes in early neonatal listeriosis are 1a and 1b, while serotype 4a is more prevalent in the late form. In this report, a neonatal L.monocytogenes meningitis case developed in a female infant born after 36 weeks of gestation from a 29 years old mother, was presented. The newborn was hospitalized in intensive care unit because of low birth weight (1740 g) and prematurity. Due to the worsening of her general condition (feedings difficulty, tachypnea, high fever and bulging fontanel) on the 11th day, blood and cerebrospinal fluid (CSF) cultures were done. CSF culture yielded catalase positive, oxidase negative, gram-positive bacilli on the 4th day of cultivation. The isolate was identified as Listeria monocytogenes and found susceptible to all tested antibiotics (erythromycin, gentamicin, penicillin, trimethoprim sulphamethoxazole, vancomycin, teicoplanin) by automated identification and antibiogram system (VITEC 2, bioMérieux, France). The empirical treatment initiated with vancomycin and meropenem was changed to ampicillin and gentamicin and clinical and microbiological response was obtained. The isolate was serotyped as type 1/2b. No data related to maternal infection or environmental contamination were obtained from the studies investigating the origin of infection. There have been no reported cases of neonatal Listeria meningitis from Turkey in the avaliable literature. This was the first case of neonatal Listeria meningitis in our country and it was presented to withdraw attention to L.monocytogenes serotype 1/2b which was a rare cause of late onset neonatal listeriosis.
authors.affiliation: Zekai Tahir Burak Women's Health Training and Research Hospital, Clinic of Neonatology, Ankara, Turkey. serifesuna@gmail.com
authors.forename: Serife Suna
authors.initials: SS
authors.lastname: Oğuz
authors.forename: Avidan
authors.initials: A
authors.lastname: Kızılelma
authors.forename: Omer
authors.initials: O
authors.lastname: Erdeve
authors.forename: Sema
authors.initials: S
authors.lastname: Zergeroğlu
authors.forename: Sibel
authors.initials: S
authors.lastname: Saygan
authors.forename: Selçuk
authors.initials: S
authors.lastname: Kılıç
authors.forename: Uğur
authors.initials: U
authors.lastname: Dilmen
mesh_terms: D000667:Ampicillin / Q000494:pharmacology / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002555:Cerebrospinal Fluid / Q000382:microbiology; D004359:Drug Therapy, Combination; D005260:Female; D005839:Gentamicins / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy / Q000382:microbiology*; D008089:Listeria monocytogenes / Q000145:classification* / Q000187:drug effects / Q000302:isolation & purification; D008584:Meningitis, Listeria / Q000188:drug therapy / Q000382:microbiology*; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D012703:Serotyping; D013845:Thienamycins / Q000494:pharmacology / Q000627:therapeutic use; D014640:Vancomycin / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D013845:Thienamycins; D014640:Vancomycin; D000667:Ampicillin; D000077731:Meropenem