title: Antifibrotic constituents from Garcinia mangostana.
abstract: From the CHCl3-soluble fraction of the fruits of Garcinia mangostana (Clusiaceae), six xanthone derivatives, alpha-mangostin (1), gamma-mangostin (2), gartanin (3), deoxygartanin (4), 1-isomangstanin (5) and garcinone E (6), were isolated. All these compounds significantly inhibited HSC-T6 viability as assessed by employing HSC-T6 hepatic stellate cells as an in vitro assay system. Among them, compounds 1 and 2, the most potent and major constituents of G. mangostana, inhibited HSC-T6 viability in dose- and time-dependent manners. In addition, compounds 1 and 2 significantly reduced collagen content, a pathological characteristic of liver fibrosis. Taken together, G. mangostana and its constituents might be beneficial for the treatment of liver fibrosis.
authors.affiliation: College of Pharmacy, Dongguk University-Seoul, Seoul 100-715, Korea.
authors.forename: Young-Won
authors.initials: YW
authors.lastname: Chin
authors.forename: Eunjin
authors.initials: E
authors.lastname: Shin
authors.forename: Bang Yeon
authors.initials: BY
authors.lastname: Hwang
authors.forename: Mi Kyeong
authors.initials: MK
authors.lastname: Lee
mesh_terms: D000818:Animals; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D005638:Fruit / Q000737:chemistry; D029760:Garcinia / Q000737:chemistry*; D055166:Hepatic Stellate Cells / Q000187:drug effects; D015394:Molecular Structure; D051381:Rats; D044004:Xanthones / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D044004:Xanthones