title: Rapid immune recovery and low TRM in haploidentical stem cell transplantation in children and adolescence using CD3/CD19-depleted stem cells.
abstract: Allogeneic stem cell transplantation has become an important option in the curative treatment of many patients with malignant and non-malignant systemic diseases. Non-availability of HLA identical donors can limit access to this life-saving treatment, especially in ethnic minority patients, for whom identical donors are often not available [1,2]. For many years, a central aim has been the development of stem cell transplantation across the HLA barrier and the use of haploidentical parents as stem cell donors. Such an approach will allow allogeneic transplantation of all patients in need. During the past years, it has become possible to optimize in vitro graft manipulation procedures making this transplant procedure safer and more efficient. Therefore this haploidentical transplantation procedure can now serve as a basis for further cellular immunotherapy in the treatment of malignant and non-malignant diseases.
authors.affiliation: Hospital for Children and Adolescents II/III, University Hospital Frankfurt, Theodor Stern Kai 7, Frankfurt, Germany. peter.bader@kgu.de
authors.forename: Peter
authors.initials: P
authors.lastname: Bader
authors.forename: Jan
authors.initials: J
authors.lastname: Soerensen
authors.forename: Andrea
authors.initials: A
authors.lastname: Jarisch
authors.forename: Eva
authors.initials: E
authors.lastname: Ponstingl
authors.forename: Thomas
authors.initials: T
authors.lastname: Krenn
authors.forename: Jörg
authors.initials: J
authors.lastname: Faber
authors.forename: Matthias
authors.initials: M
authors.lastname: Dürken
authors.forename: Harald
authors.initials: H
authors.lastname: Reinhardt
authors.forename: Andre
authors.initials: A
authors.lastname: Willasch
authors.forename: Ruth
authors.initials: R
authors.lastname: Esser
authors.forename: Halvard
authors.initials: H
authors.lastname: Bönig
authors.forename: Ulrike
authors.initials: U
authors.lastname: Koehl
authors.forename: Thomas
authors.initials: T
authors.lastname: Klingebiel
mesh_terms: D000293:Adolescent; D018941:Antigens, CD19; D017252:CD3 Complex; D002648:Child; D002675:Child, Preschool; D005260:Female; D006650:Histocompatibility Testing; D006801:Humans; D008212:Lymphocyte Depletion; D008297:Male; D009369:Neoplasms / Q000276:immunology / Q000401:mortality / Q000628:therapy; D020127:Recovery of Function / Q000276:immunology*; D033581:Stem Cell Transplantation; D014019:Tissue Donors; D014184:Transplantation, Homologous
chemical_list: D018941:Antigens, CD19; D017252:CD3 Complex