title: Convergent synthesis of the tetrasaccharide repeating unit corresponding to the O-antigen of the verotoxin-producing Escherichia coli O176.
abstract: A convergent synthesis of the tetrasaccharide repeating unit of the O-antigen of the verotoxin producing E. coli O176 has been achieved in excellent yield adopting a [2+2] block glycosylation strategy. The β-D-mannosidic moiety of the tetrasaccharide was prepared from β-D-glucoside and α-D-galactosamine moiety was derived from D-galactal. The tetrasaccharide was synthesized as its 2-trimethylsilylethyl glycoside in excellent yield. All intermediate steps are high yielding.
authors.affiliation: Molecular Medicine Division, Bose Institute, P-1/12, C.I.T. Scheme VII M, Kolkata 700054, India.
authors.forename: Goutam
authors.initials: G
authors.lastname: Guchhait
authors.forename: Anup Kumar
authors.initials: AK
authors.lastname: Misra
mesh_terms: D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D008969:Molecular Sequence Data; D019081:O Antigens / Q000737:chemistry*; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry*; D054323:Shiga-Toxigenic Escherichia coli / Q000737:chemistry*
chemical_list: D019081:O Antigens; D009844:Oligosaccharides