title: [Investigating the incidence of injection-site reactions associated with administration of oxaliplatin into a peripheral vein and management local adverse reactions].
abstract: In Aichi Cancer Center Hospital, we investigated the incidence of injection-site reactions associated with the administration of Oxaliplatin into a peripheral vein. We evaluated the frequency and severity of symptoms, and studied ways to manage its adverse reactions from September 2009 through March 2010. Oxaliplatin was injected into a peripheral vein in more than 90% of patients, suggesting that there would be a high risk of injection-site reactions. About 60% of patients had a numeric rating score of 5 or higher in this study, and more than 60% of injection-site reactions were improved by warming the injection site. Our results suggest that warming the injection site is one effective way to manage local adverse reactions when Oxaliplatin is administered into a peripheral vein.
authors.affiliation: Dept. of Hospital Pharmacy, Nagoya Memorial Hospital.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hibi
authors.forename: Michiko
authors.initials: M
authors.lastname: Tatematsu
authors.forename: Satomi
authors.initials: S
authors.lastname: Nishio
authors.forename: Michiko
authors.initials: M
authors.lastname: Miyatani
authors.forename: Kanae
authors.initials: K
authors.lastname: Tosaki
authors.forename: Makiko
authors.initials: M
authors.lastname: Ohara
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Maeda
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Tomita
authors.forename: Masaru
authors.initials: M
authors.lastname: Kawai
authors.forename: Kenji
authors.initials: K
authors.lastname: Ina
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Oishi
authors.forename: Kei
authors.initials: K
authors.lastname: Muro
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D005260:Female; D006358:Hot Temperature; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000077150:Oxaliplatin; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D014680:Veins / Q000187:drug effects
chemical_list: D009944:Organoplatinum Compounds; D000077150:Oxaliplatin