title: ETS-1 proto-oncogene as a key newcomer molecule to predict invasiveness in laryngeal carcinoma.
abstract: ETS-1 protein is one of the key regulators in tumor invasion and progression. We aimed to evaluate the role of ETS-1 in the invasiveness and progression of laryngeal squamous carcinoma, as well as to determine the correlations between clinicopathological characteristics and expression of this molecule. We assessed the levels of ETS-1 in a total of 96 laryngeal specimens of varying degrees of dysplasia, microinvasive squamous carcinoma (8), and invasive squamous carcinoma (60), using normal mucosal epithelium (10) as a positive control. The relationship between ETS-1 expression and clinicopathological parameters of laryngeal carcinoma was also analyzed. We found a significantly higher ETS-1 expression in invasive laryngeal squamous cell carcinomas than in dysplasia (P<0.001). A correlation between ETS-1 expression scores and grade was detected - T factor, stage, cartilage invasion, lymph node metastasis, as well as depth of invasion in laryngeal tumors. Our study is the first to demonstrate that ETS-1 expression is significantly increased in invasive carcinoma, but it is absent in low-moderate grade laryngeal dysplasia and non-neoplastic laryngeal mucosa. This data suggest that ETS-1 expression may play an important role in tumor invasion, and may function in the initiation of the invasive process in laryngeal squamous cell carcinoma.
authors.affiliation: Izmir Training and Research Hospital, Department of Pathology, Yesilyurt, Turkey. calliaylin@gmail.com
authors.forename: Aylin Orgen
authors.initials: AO
authors.lastname: Calli
authors.forename: Aysegul
authors.initials: A
authors.lastname: Sari
authors.forename: Fulya
authors.initials: F
authors.lastname: Cakalagaoglu
authors.forename: Aysegul Aksoy
authors.initials: AA
authors.lastname: Altinboga
authors.forename: Semih
authors.initials: S
authors.lastname: Oncel
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D008297:Male; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness / Q000235:genetics; D009367:Neoplasm Staging; D000090063:Proto-Oncogene Mas; D050784:Proto-Oncogene Protein c-ets-1 / Q000096:biosynthesis* / Q000235:genetics
chemical_list: C494041:ETS1 protein, human; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D050784:Proto-Oncogene Protein c-ets-1