title: Aminoacyl-tRNA synthetases and tumorigenesis: more than housekeeping.
abstract: Over the past decade, the identification of cancer-associated factors has been a subject of primary interest not only for understanding the basic mechanisms of tumorigenesis but also for discovering the associated therapeutic targets. However, aminoacyl-tRNA synthetases (ARSs) have been overlooked, mostly because many assumed that they were simply 'housekeepers' that were involved in protein synthesis. Mammalian ARSs have evolved many additional domains that are not necessarily linked to their catalytic activities. With these domains, they interact with diverse regulatory factors. In addition, the expression of some ARSs is dynamically changed depending on various cellular types and stresses. This Analysis article addresses the potential pathophysiological implications of ARSs in tumorigenesis.
authors.affiliation: Medicinal Bioconvergence Research Center, WCU Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul 151-742, Republic of Korea. sungkim@snu.ac.kr
authors.forename: Sunghoon
authors.initials: S
authors.lastname: Kim
authors.forename: Sungyong
authors.initials: S
authors.lastname: You
authors.forename: Daehee
authors.initials: D
authors.lastname: Hwang
mesh_terms: D000604:Amino Acyl-tRNA Synthetases / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology*; D009385:Neoplastic Processes; D011485:Protein Binding; D015398:Signal Transduction
chemical_list: D000604:Amino Acyl-tRNA Synthetases