title: Development of vaccines to prevent malaria in pregnant women: WHO MALVAC meeting report.
abstract: The major public health consequences of malaria in pregnancy have long been acknowledged. However, further information is still required for development and implementation of a malaria vaccine specifically directed to prevent malaria in pregnant women and improve maternal, fetal and infant outcomes. The WHO Malaria Vaccine Advisory Committee (MALVAC) provides guidance to the WHO on strategic priorities and research needs for development of vaccines to prevent malaria. Here we summarize the discussions and conclusions of a MALVAC scientific forum meeting on considerations in the development of vaccines to prevent malaria in pregnant women. This report includes brief summaries of what is known, and major knowledge gaps in disease burden estimation, pathogenesis and immunity, and the challenges with current preventive strategies for malaria in pregnancy. We conclude with the formulation of a conceptual framework for research and development for vaccines to prevent malaria in pregnant women.
authors.affiliation: Barcelona Center for International Health Research (CRESIB), Hospital Clinic/Universitat de Barcelona, Barcelona, Spain.
authors.forename: Clara
authors.initials: C
authors.lastname: Menéndez
authors.forename: Vasee S
authors.initials: VS
authors.lastname: Moorthy
authors.forename: Zarifah
authors.initials: Z
authors.lastname: Reed
authors.forename: Azucena
authors.initials: A
authors.lastname: Bardají
authors.forename: Pedro
authors.initials: P
authors.lastname: Alonso
authors.forename: Graham V
authors.initials: GV
authors.lastname: Brown
mesh_terms: D026683:Advisory Committees; D017954:Africa South of the Sahara / Q000453:epidemiology; D001208:Asia / Q000453:epidemiology; D002986:Clinical Trials as Topic; D003906:Developing Countries; D005260:Female; D005333:Fetus; D006291:Health Policy; D006801:Humans; D007114:Immunization; D007223:Infant; D007843:Latin America / Q000453:epidemiology; D017780:Malaria Vaccines / Q000096:biosynthesis / Q000138:chemical synthesis / Q000276:immunology; D016778:Malaria, Falciparum / Q000453:epidemiology / Q000276:immunology / Q000469:parasitology / Q000503:physiopathology / Q000517:prevention & control*; D016780:Malaria, Vivax / Q000453:epidemiology / Q000276:immunology / Q000469:parasitology / Q000503:physiopathology / Q000517:prevention & control*; D010963:Plasmodium falciparum / Q000502:physiology; D010966:Plasmodium vivax / Q000502:physiology; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology / Q000517:prevention & control*; D011634:Public Health; D014944:World Health Organization
chemical_list: D017780:Malaria Vaccines