title: Biosynthesis, characterization and biological evalutation of Fe(III) and Cu(II) complexes of neoaspergillic acid, a hydroxamate siderophore produced by co-cultures of two marine-derived mangrove epiphytic fungi.
abstract: A hydroxamate siderophore, neoaspergillic acid (1), and a red pigment, ferrineoaspergillin (2) which is an Fe(III) complex of 1, were produced by co-cultures of two epiphytic fungi from a rotten fruit of the mangrove Avicennia marina from the South China Sea, and a new Cu(II) complex of 1, designated as cuprineoaspergillin (3), was also prepared by treatment of 1 with cupric acetate. All the compounds (1-3) were characterized by physical and chemical techniques, including 1H NMR, ESIMS, and photoelectron energy spectra. In the bioassays, compounds 1-3 showed significant inhibitory activities against selected Gram-positive and Gram-negative bacteria, and compound 1 also exhibited moderate inhibitory activities against human cancer cell lines SPC-A-1, BEL-7402, SGC-7901 and K562.
authors.affiliation: Department of Chemistry and Chemical Engineering, Foshan University, Foshan 528000, P. R. China. drzhu.feng@163.com
authors.forename: Feng
authors.initials: F
authors.lastname: Zhu
authors.forename: Jingshu
authors.initials: J
authors.lastname: Wu
authors.forename: Guangying
authors.initials: G
authors.lastname: Chen
authors.forename: Weihong
authors.initials: W
authors.lastname: Lu
authors.forename: Jiahui
authors.initials: J
authors.lastname: Pan
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D032407:Avicennia / Q000382:microbiology*; D045744:Cell Line, Tumor; D018920:Coculture Techniques; D003300:Copper / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D005290:Ferric Compounds / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D005638:Fruit / Q000382:microbiology; D005670:Fusarium / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D009942:Organometallic Compounds / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D011719:Pyrazines / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D005290:Ferric Compounds; D009942:Organometallic Compounds; D011719:Pyrazines; C561831:cuprineoaspergillin; C561830:ferrineoaspergillin; C004524:aspergillic acid; D003300:Copper; D007501:Iron