title: Microtubule-based motor-mediated mRNA localization in Drosophila oocytes and embryos.
abstract: RNA localization coupled to translational repression is a general mechanism for creating structural and functional asymmetry within the cell. While there are many possible ways to target an mRNA to its destination, a large fraction of the studied transcripts undertake active transport mediated by cytoskeletal elements (microtubules and actin filaments) and associated mechanoenzymes. Among the best-studied model systems of RNA localization are the oocyte and the early embryo of Drosophila melanogaster, for which many well-characterized tools have been developed to study this cell biological phenomenon in a dynamic, developing system in its in vivo context. In the present paper, we review the current evidence and models explaining the different modes of RNA localization that depend on active transport within cells.
authors.affiliation: EMBL Heidelberg, Developmental Biology Unit, D-69117 Heidelberg, Germany. imre.gaspar@embl.de
authors.forename: Imre
authors.initials: I
authors.lastname: Gaspar
mesh_terms: D000818:Animals; D001692:Biological Transport; D003599:Cytoskeleton / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D004331:Drosophila melanogaster / Q000166:cytology* / Q000196:embryology* / Q000235:genetics* / Q000378:metabolism; D004625:Embryo, Nonmammalian / Q000166:cytology / Q000502:physiology; D008870:Microtubules / Q000378:metabolism*; D020409:Molecular Motor Proteins / Q000235:genetics / Q000378:metabolism*; D009865:Oocytes / Q000166:cytology / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; D020409:Molecular Motor Proteins; D012333:RNA, Messenger