title: On the development of markers for pathological TDP-43 in amyotrophic lateral sclerosis with and without dementia.
abstract: Pathological 43-kDa transactive response sequence DNA-binding protein (TDP-43) has been recognized as the major disease protein in amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration with ubiquitin positive, tau and α-synuclein negative inclusions (FTLD-U) and the transitional forms between these multisystem conditions. In order to develop TDP-43 into a successful ALS biomarker, the natural history of TDP-43 pathology needs to be characterized and the underlying pathophysiology established. Here we propose a spatial and temporal "two-axes" model of central nervous system vulnerability for TDP-43 linked degeneration and review recent studies on potential biomarkers related to pathological TDP-43 in the cerebrospinal fluid (CSF), blood, and skeletal muscle. The model includes the following two arms: Firstly, a "motor neuron disease" or "spinal cord/brainstem to motor cortex" axis (with degeneration possibly ascending from the lower motor neurons to the upper motor neurons); and secondly, a "dementia" or "corticoid/allocortex to neocortex" axis (with a probable spread of TDP-43 linked degeneration from the mediotemporal lobe to wider mesocortical and neocortical brain areas). At the cellular level, there is a gradual disappearance of normal TDP-43 in the nucleus in combination with the formation of pathological aggregates in the cell body and cellular processes, which can also be used to identify the stage of the disease process. Moreover, TDP-43 lesions in subpial/subependymal or perivascular localizations have been noted, and this might account for increased CSF and blood TDP-43 levels through mechanisms that remain to be elucidated.
authors.affiliation: Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe-University, Frankfurt am Main, Germany. felix.geser@alumni.i-med.ac.at
authors.forename: F
authors.initials: F
authors.lastname: Geser
authors.forename: D
authors.initials: D
authors.lastname: Prvulovic
authors.forename: L
authors.initials: L
authors.lastname: O'Dwyer
authors.forename: O
authors.initials: O
authors.lastname: Hardiman
authors.forename: P
authors.initials: P
authors.lastname: Bede
authors.forename: A L W
authors.initials: AL
authors.lastname: Bokde
authors.forename: J Q
authors.initials: JQ
authors.lastname: Trojanowski
authors.forename: H
authors.initials: H
authors.lastname: Hampel
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000150:complications / Q000378:metabolism / Q000473:pathology; D004268:DNA-Binding Proteins / Q000378:metabolism*; D003704:Dementia / Q000150:complications*; D006801:Humans; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins