title: Bone disease and cytokines in idiopathic hypercalciuria: a review.
abstract: Bone remodeling is a continuous and dynamic process of skeletal destruction and renewal. A complex regulatory mechanism with the participation of several cytokines precisely defines the role of osteoclasts in the chain of events leading to bone resorption. There are multiple mechanisms underlying the regulation of bone resorption, which can involve increased calcium excretion and decreased bone density in patients with idiopathic hypercalciuria (IH). However, the pathogenesis of bone mass reduction in IH remains uncertain. The purpose of this review is to summarize the recent published evidence on the possible mechanisms by which cytokines could be associated with the pathogenesis of IH.
authors.affiliation: Department of Pediatrics, Pediatric Nephrology Unit, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Augusto C S
authors.initials: AC
authors.lastname: Santos
authors.forename: Eleonora M
authors.initials: EM
authors.lastname: Lima
authors.forename: Eduardo Araújo
authors.initials: EA
authors.lastname: Oliveira
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: Simões e Silva
mesh_terms: D000818:Animals; D001847:Bone Diseases / Q000378:metabolism* / Q000503:physiopathology*; D001862:Bone Resorption / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D053565:Hypercalciuria / Q000209:etiology*; D010010:Osteoclasts / Q000378:metabolism
chemical_list: D016207:Cytokines