title: Systolic synchrony is impaired in nonleft ventricular hypertrophy of never-treated hypertensive patients.
abstract: OBJECTIVE
  The objective of the current study was to confirm the degrees of dyssynchrony in patients with nonleft ventricular hypertrophy (LVH) and never-treated hypertension compared with normal controls or patients with LVH and never-treated hypertension.
  
  
  RESULTS
  We enrolled 200 consecutive never-treated hypertensive patients and 104 age-matched and sex-matched normal controls. The following parameters were evaluated by echocardiography comprising conventional Doppler, tissue Doppler imaging, and strain imaging: global dyssynchrony; systolic dyssynchrony (longitudinal); diastolic dyssynchrony; and contractile diastolic dyssynchrony. Systolic dyssynchrony in the LVH group with hypertension was more aggravated than in normal controls (P < 0.001). In addition, global, diastolic, and contractile diastolic dyssynchrony in the LVH group with hypertension were more aggravated than in the non-LVH group with hypertension (all P < 0.001), but systolic dyssynchrony was not different between the two groups. All of the above associations remained significant after adjustment for confounding factors.
  
  
  CONCLUSIONS
  Systolic synchrony was impaired in patients with non-LVH and never-treated hypertension to a similar degree in the LVH group with never-treated hypertension.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Beom-June
authors.initials: BJ
authors.lastname: Kwon
authors.forename: Kyu-Young
authors.initials: KY
authors.lastname: Choi
authors.forename: Dong-Bin
authors.initials: DB
authors.lastname: Kim
authors.forename: Sung-Won
authors.initials: SW
authors.lastname: Jang
authors.forename: Eun-Joo
authors.initials: EJ
authors.lastname: Cho
authors.forename: Ho-Joong
authors.initials: HJ
authors.lastname: Youn
authors.forename: Jae-Hyung
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D003971:Diastole; D004452:Echocardiography / Q000379:methods; D018618:Echocardiography, Doppler, Color / Q000379:methods; D005260:Female; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000473:pathology* / Q000628:therapy; D017379:Hypertrophy, Left Ventricular / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D013599:Systole