title: A pattern of cerebral perfusion anomalies between major depressive disorder and Hashimoto thyroiditis.
abstract: BACKGROUND
  This study aims to evaluate relationship between three different clinical conditions: Major Depressive Disorders (MDD), Hashimoto Thyroiditis (HT) and reduction in regional Cerebral Blood Flow (rCBF) in order to explore the possibility that patients with HT and MDD have specific pattern(s) of cerebral perfusion.
  
  
  METHODS
  
  
  
  METHODS
  Analysis of data derived from two separate data banks.
  
  
  METHODS
  54 subjects, 32 with HT (29 women, mean age 38.8 ± 13.9); 22 without HT (19 women, mean age 36.5 ± 12.25).
  
  
  RESULTS
  Psychiatric diagnosis was carried out by Simplified Composite International Diagnostic Interview (CIDIS) using DSM-IV categories; cerebral perfusion was measured by (99 m)Tc-ECD SPECT. Statistical analysis was done through logistic regression.
  
  
  RESULTS
  MDD appears to be associated with left frontal hypoperfusion, left temporal hypoperfusion, diffuse hypoperfusion and parietal perfusion asymmetry. A statistically significant association between parietal perfusion asymmetry and MDD was found only in the HT group.
  
  
  CONCLUSIONS
  In HT, MDD is characterized by a parietal flow asymmetry. However, the specificity of rCBF in MDD with HT should be confirmed in a control sample with consideration for other health conditions. Moreover, this should be investigated with a longitudinally designed study in order to determine a possible pathogenic cause. Future studies with a much larger sample size should clarify whether a particular perfusion pattern is associated with a specific course or symptom cluster of MDD.
authors.affiliation: Department of Psychiatry, Reald University, Vlore, Albania. carolinahardoy@tiscali.it
authors.forename: Maria Carolina
authors.initials: MC
authors.lastname: Hardoy
authors.forename: Mariangela
authors.initials: M
authors.lastname: Cadeddu
authors.forename: Alessandra
authors.initials: A
authors.lastname: Serra
authors.forename: Maria Francesca
authors.initials: MF
authors.lastname: Moro
authors.forename: Gioia
authors.initials: G
authors.lastname: Mura
authors.forename: Gisa
authors.initials: G
authors.lastname: Mellino
authors.forename: Krishna M
authors.initials: KM
authors.lastname: Bhat
authors.forename: Gianmarco
authors.initials: G
authors.lastname: Altoé
authors.forename: Paolo
authors.initials: P
authors.lastname: Usai
authors.forename: Mario
authors.initials: M
authors.lastname: Piga
authors.forename: Mauro G
authors.initials: MG
authors.lastname: Carta
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002446:Celiac Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002561:Cerebrovascular Disorders / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D003545:Cysteine / Q000031:analogs & derivatives; D003865:Major Depressive Disorder / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006042:Goiter / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D050031:Hashimoto Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C059659:technetium Tc 99m bicisate; D003545:Cysteine