title: Genomic relationship between SINE retrotransposons, Pol III-Pol II transcription, and chromatin organization: the journey from junk to jewel.
abstract: A typical eukaryotic genome harbors a rich variety of repetitive elements. The most abundant are retrotransposons, mobile retroelements that utilize reverse transcriptase and an RNA intermediate to relocate to a new location within the cellular genomes. A vast majority of the repetitive mammalian genome content has originated from the retrotransposition of SINE (100-300 bp short interspersed nuclear elements that are derived from the structural 7SL RNA or tRNA), LINE (7kb long interspersed nuclear element), and LTR (2-3 kb long terminal repeats) transposable element superfamilies. Broadly labeled as "evolutionary junkyard" or "fossils", this enigmatic "dark matter" of the genome possesses many yet to be discovered properties.
authors.affiliation: Buck Institute for Age Research, Novato, CA 94945, USA. vlunyak@buckinstitute.org
authors.forename: Victoria V
authors.initials: VV
authors.lastname: Lunyak
authors.forename: Michelle
authors.initials: M
authors.lastname: Atallah
mesh_terms: D000818:Animals; D002843:Chromatin / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D004257:DNA Polymerase II / Q000235:genetics / Q000378:metabolism*; D004258:DNA Polymerase III / Q000235:genetics / Q000378:metabolism*; D016678:Genome; D006801:Humans; D051379:Mice; D018626:Retroelements / Q000235:genetics*; D020086:Short Interspersed Nucleotide Elements / Q000235:genetics*
chemical_list: D002843:Chromatin; D018626:Retroelements; D004257:DNA Polymerase II; D004258:DNA Polymerase III