title: Total synthesis of (+)-decursivine.
abstract: The first asymmetric synthesis of natural indole alkaloid (+)-decursivine was accomplished. The key step involves the PIFA-mediated intramolecular [3 + 2] cycloaddition of 5-hydroxytryptophan with a substituted cinnamamide in a highly diastereoselective manner.
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, PR China.
authors.forename: Deqian
authors.initials: D
authors.lastname: Sun
authors.forename: Qiwu
authors.initials: Q
authors.lastname: Zhao
authors.forename: Chaozhong
authors.initials: C
authors.lastname: Li
mesh_terms: D006916:5-Hydroxytryptophan / Q000737:chemistry; D002934:Cinnamates / Q000737:chemistry; D003500:Cyclization; D026121:Indole Alkaloids / Q000138:chemical synthesis*; D008958:Models, Molecular; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D002934:Cinnamates; D026121:Indole Alkaloids; C560343:decursivine; D006916:5-Hydroxytryptophan; C411088:cinnamamide