title: Bioactive myrsinol diterpenoids from the roots of Euphorbia prolifera.
abstract: Ten myrsinol diterpenes, euphorbiaproliferins A-J (1-10), along with nine known analogues (11-19) were isolated from the roots of Euphorbia prolifera. Their structures were elucidated by spectroscopic data analysis (IR, ESIMS, HRESIMS, 1D and 2D NMR), and the structure of 1 was confirmed by X-ray crystallography. The diterpenes showed neuroprotective effects against MPP+-induced neuronal cell death in SH-SY5Y cells.
authors.affiliation: College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Yuanqiang
authors.initials: Y
authors.lastname: Guo
authors.forename: Chunfeng
authors.initials: C
authors.lastname: Xie
authors.forename: Yushan
authors.initials: Y
authors.lastname: Li
authors.forename: Jie
authors.initials: J
authors.lastname: Gao
authors.forename: Tiejun
authors.initials: T
authors.lastname: Zhang
authors.forename: Wenbin
authors.initials: W
authors.lastname: Hou
authors.forename: Lingzhi
authors.initials: L
authors.lastname: Fang
authors.forename: Liping
authors.initials: L
authors.lastname: Gui
mesh_terms: D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D028481:Euphorbia / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry
chemical_list: D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents