title: Three-year clinical outcome using the Contura multilumen balloon breast brachytherapy catheter to deliver accelerated partial breast irradiation (APBI): improving radiation standards for the optimal application of APBI.
abstract: OBJECTIVE
  We reviewed our institution's 3-year clinical experience in treating patients with the Contura multilumen balloon (SenoRx, Inc., Aliso Viejo, CA) breast brachytherapy catheter to deliver accelerated partial breast irradiation (APBI).
  
  
  METHODS
  Forty-six patients treated with breast-conserving therapy received adjuvant radiation using the Contura catheter (34Gy in 3.4Gy fractions). Fourteen patients had Stage 0, 24 had Stage I, and 8 had Stage II breast cancer. Median follow-up was 36 months (range, 1-44 months).
  
  
  RESULTS
  Only one local recurrence developed (2%). The rate of persistent seroma formation at latest reported follow-up was 4.3% (2 patients) and the incidence of any clinically detectable telengiectasias was 2.2%. No major toxicities (0% Grade III) have occurred. The median skin dose (% of the prescribed dose) was 99.7. The median dose to 95% of the planning target volume for evaluation was 98.8%. The percentage of patients with excellent/good cosmetic results at 24 (n=23) and 36 (n=22) months was 100% and 97%, respectively.
  
  
  CONCLUSIONS
  Adjuvant APBI using the Contura multilumen balloon catheter exhibited similar locoregional control, cosmesis, and toxicities to other forms of APBI with similar lengths of follow-up. In addition, improved radiation standards for the delivery of APBI were demonstrated.
authors.affiliation: The Breast Center, Marietta, GA 30060, USA. pzisrael@aol.com
authors.forename: Philip Z
authors.initials: PZ
authors.lastname: Israel
authors.forename: Angela
authors.initials: A
authors.lastname: Robbins
authors.forename: Paulomi
authors.initials: P
authors.lastname: Shroff
authors.forename: Sheree
authors.initials: S
authors.lastname: Brown
authors.forename: Mark
authors.initials: M
authors.lastname: McLaughlin
authors.forename: Keith
authors.initials: K
authors.lastname: Pope
mesh_terms: D000328:Adult; D000368:Aged; D001918:Brachytherapy / Q000295:instrumentation* / Q000592:standards*; D001943:Breast Neoplasms / Q000532:radiotherapy*; D002404:Catheterization / Q000295:instrumentation* / Q000592:standards*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D012189:Retrospective Studies; D016896:Treatment Outcome; D014481:United States