title: HCMV grabs a mechanism to escape neutralization.
abstract: The HCMV-neutralizing monoclonal antibody MSL-109 failed to prevent HCMV-induced disease in the clinic. In this issue of Cell Host & Microbe, Manley et al. (2011) found that MSL-109 rapidly induces antibody resistance by a nongenetic mechanism. Their results shed light on how antibodies can interact with their targets both outside and inside infected cells and virions.
authors.affiliation: School of Veterinary Medicine, University of Pennsylvania, Philadelphia, USA. roselyn@dental.upenn.edu
authors.forename: Roselyn J
authors.initials: RJ
authors.lastname: Eisenberg
authors.forename: Tina M
authors.initials: TM
authors.lastname: Cairns
authors.forename: Gary H
authors.initials: GH
authors.lastname: Cohen
mesh_terms: D057134:Antibodies, Neutralizing / Q000276:immunology*; D000914:Antibodies, Viral / Q000276:immunology*; D003587:Cytomegalovirus / Q000502:physiology*; D003586:Cytomegalovirus Infections / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D014771:Virion / Q000502:physiology*; D019065:Virus Assembly
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral