title: DPPH radical scavenging and xanthine oxidase inhibitory activity of Terminalia macroptera leaves.
abstract: From a methanol extract of the leaves of the Malian medicinal tree Terminalia macroptera, cis-polyisoprene (1), chebulic acid trimethyl ester (2), methyl gallate (3), shikimic acid (4), corilagin (5), rutin (6), narcissin (7), chebulagic acid (8) and chebulinic acid (9), were isolated. Cispolyisoprene (1) was the major non-polar constituent. The novel compound 2 showed high radical scavenging activity (IC50 4.7 microg/mL), but was inactive as xanthine oxidase inhibitor. The major substituent of the crude extract, substance 5, showed a high radical scavenger effect (IC50 2.7 microg/mL) and weak xanthine oxidase inhibition (IC50 ca 105 microg/mL). The antioxidant and radical scavenging effects of some of the substances identified in this study may to some extent explain the medical use of this tree in West Africa.
authors.affiliation: Section of Pharmacognosy, Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, N-0316 Oslo, Norway. a.t.pham@farmasi.uio.no
authors.forename: Anh Thu
authors.initials: AT
authors.lastname: Pham
authors.forename: Karl Egil
authors.initials: KE
authors.lastname: Malterud
authors.forename: Berit Smestad
authors.initials: BS
authors.lastname: Paulsen
authors.forename: Drissa
authors.initials: D
authors.lastname: Diallo
authors.forename: Helle
authors.initials: H
authors.lastname: Wangensteen
mesh_terms: D001713:Biphenyl Compounds / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology*; D008302:Mali; D015394:Molecular Structure; D010851:Picrates / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry*; D010946:Plants, Medicinal; D029766:Terminalia / Q000737:chemistry*; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
chemical_list: D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D010936:Plant Extracts; C004931:1,1-diphenyl-2-picrylhydrazyl; D014969:Xanthine Oxidase