title: Prognostic significance of IDH-1 and MGMT in patients with glioblastoma: one step forward, and one step back?
abstract: A group of 160 patients with primary glioblastoma treated with radiotherapy and temozolomide was analyzed for the impact of O6-methly-guanly-methyl-transferase (MGMT)-promoter methylation as well as isocitrate dehydrogenase (IDH)1-mutational status. Unexpectedly, overall survival or progression-free survival were not longer in the group with methylated MGMT-promoter as compared to patients without that methylation. IDH-1 mutations were significantly associated with increased overall survival.
authors.affiliation: Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany. stephanie.combs@med.uni-heidelberg.de
authors.forename: Stephanie E
authors.initials: SE
authors.lastname: Combs
authors.forename: Stefan
authors.initials: S
authors.lastname: Rieken
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Wick
authors.forename: Amir
authors.initials: A
authors.lastname: Abdollahi
authors.forename: Andreas
authors.initials: A
authors.lastname: von Deimling
authors.forename: Jürgen
authors.initials: J
authors.lastname: Debus
authors.forename: Christian
authors.initials: C
authors.lastname: Hartmann
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy*; D019175:DNA Methylation; D003606:Dacarbazine / Q000031:analogs & derivatives / Q000627:therapeutic use; D005909:Glioblastoma / Q000175:diagnosis* / Q000532:radiotherapy*; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics; D008495:Medical Oncology / Q000379:methods; D008875:Middle Aged; D009154:Mutation; D019853:O(6)-Methylguanine-DNA Methyltransferase / Q000235:genetics; D011379:Prognosis; D011401:Promoter Regions, Genetic; D000077204:Temozolomide; D016896:Treatment Outcome
chemical_list: D003606:Dacarbazine; D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human; D019853:O(6)-Methylguanine-DNA Methyltransferase; D000077204:Temozolomide