title: Postprandial triglyceridemia after single dose of alcohol in healthy young men.
abstract: OBJECTIVE
  Moderate alcohol consumption provides protection against cardiovascular disease primarily due to increase of HDL-cholesterol. However, it also has some adverse effects on metabolism of triglycerides (TG). Therefore, we addressed the question how a single dose of alcohol affects postprandial lipemia and activities of two enzymes playing a critical role in regulation of triglyceridemia, lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL).
  
  
  RESULTS
  Eight healthy volunteers were given a single dose of alcohol (vodka; 0.6 g of ethanol/kg of body weight) together with a fat load (0.7 g of fat/kg of body weight) in an experimental breakfast or together with dinner 12 h before the experimental breakfast. In comparison to control experiment, alcohol given with breakfast induced increased and prolonged postprandial response of triglyceride-rich lipoproteins (TRL; d < 1.006 g/ml). At the same time TG accumulated also in intermediate density lipoproteins (IDL; d 1.006-1.019 g/ml). Alcohol given in the evening before the experiment increased fasting TG concentration but did not affect changes in TRL and IDL concentrations. LPL activity measured both in vivo using intravenous fat tolerance test and in vitro and HTGL activity were determined at the end of experiments (after 7.5 h of postprandial lipemia study). Neither was affected by a single dose of alcohol.
  
  
  CONCLUSIONS
  Single dose of alcohol induces immediate and profound changes in metabolism of TRL and IDL. The same dose of alcohol given 12 h before meal does affect baseline TG concentration but not the postprandial changes of triglyceridemia.
authors.affiliation: Institute for Clinical and Experimental Medicine, Prague, Vídeňská 1958/9, 140 21 Prague 4, Czech Republic.
authors.forename: E
authors.initials: E
authors.lastname: Mudráková
authors.forename: R
authors.initials: R
authors.lastname: Poledne
authors.forename: J
authors.initials: J
authors.lastname: Kovář
mesh_terms: D000328:Adult; D000434:Alcoholic Beverages; D001057:Apolipoproteins E / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage*; D005215:Fasting; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006801:Humans; D015228:Hypertriglyceridemia / Q000188:drug therapy*; D007328:Insulin / Q000097:blood; D008071:Lipoprotein Lipase / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D019518:Postprandial Period; D014280:Triglycerides / Q000097:blood*; D055815:Young Adult
chemical_list: D001057:Apolipoproteins E; D008076:Cholesterol, HDL; D004041:Dietary Fats; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D008074:Lipoproteins; D014280:Triglycerides; C030087:lipoprotein triglyceride; D000431:Ethanol; D008071:Lipoprotein Lipase