title: Novel genetic biomarkers for susceptibility to oral submucous fibrosis: cytochrome P450 3A.
abstract: Oral submucous fibrosis (OSF) is a chronic and insidious oral mucosal disease, which always carries high risk of transition to oral cancer. Mainly based on genetic predisposition in pharmacokinetics for toxic substances of betel quid, there are obviously variable responses to betel quid among chewers. But the key genes resulting in interindividual variability in OSF development are still obscure. The cytochrome P450 3A (CYP 3A) gene family plays major roles in the oxidative metabolism of active endogenous and xenobiotic substrates, which is generally found polymorphic with variant alleles in different individuals and regarded as a major determinant of the interindividual variability in chemicals pharmacokinetics. Based on the specific property of CYP 3A, we consider this polymorphically expressed genotype could be a predictor of OSF susceptibility. Betel-quid chewers with lower level of CYP 3A expression might be more susceptible to toxicity of betel quid, resulting in higher risk of OSF lesion. Meanwhile, individuals at genetically high risk of OSF could be screened according to the genetic polymorphisms in some exclusive regions of the CYP 3A genes. By analyzing the polymorphisms of CYP 3A genes, we could differentiate interindividual variability for pharmacokinetics of betel-quid chewers, and then guide OSF therapy.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, No. 87, Xiangya Road, Changsha 410008, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Qiong
authors.initials: Q
authors.lastname: Hu
authors.forename: Canhua
authors.initials: C
authors.lastname: Jiang
authors.forename: Yanjia
authors.initials: Y
authors.lastname: Hu
authors.forename: Yongxiang
authors.initials: Y
authors.lastname: Yuan
authors.forename: Xinchun
authors.initials: X
authors.lastname: Jian
authors.forename: Zhangui
authors.initials: Z
authors.lastname: Tang
authors.forename: Feng
authors.initials: F
authors.lastname: Guo
mesh_terms: D051544:Cytochrome P-450 CYP3A / Q000235:genetics*; D005819:Genetic Markers; D006801:Humans; D009061:Mouth Mucosa / Q000201:enzymology*
chemical_list: D005819:Genetic Markers; D051544:Cytochrome P-450 CYP3A