title: Platinum (II) Porphyrin-Containing Thermoresponsive Poly(N-isopropylacrylamide) Copolymer as Fluorescence Dual Oxygen and Temperature Sensor.
abstract: A random copolymer, poly(NIPAAm-co-PtPorphyrin), consisting of N-isopropylacrylamide (NIPAAm) and platinum (II) porphyrin units, behaves as an optical dual sensor for oxygen and temperature. The dual sensor is designed by incorporating an oxygen-sensitive platinum (II) porphyrin (M1) into a temperature-sensitive polymer (PNIPAAm). The polymer exhibited low critical solution temperature (LCST) property at 31.5 °C. This LCST affected the polymer's aggregation status, which in turn affected the nanostructures, fluorescence intensities, and responses to dissolved oxygen. This enables the polymer to functionalize as a dual temperature and dissolved oxygen sensor. Oxygen response of the platinum (II) porphyrin probes in the polymer followed a two-site Stern-Volmer model, indicating the nonuniform distribution of the probes. The copolymer was used to preliminarily monitor the oxygen consumption of Escherichia coli (E. coli) bacteria. The results indicate a potential application of the polymer in biological fields.
authors.affiliation: Center for Biosignatures Discovery Automation, Biodesign Institute, Arizona State University, Tempe, AZ 85287.
authors.forename: Xianfeng
authors.initials: X
authors.lastname: Zhou
authors.forename: Fengyu
authors.initials: F
authors.lastname: Su
authors.forename: Yanqing
authors.initials: Y
authors.lastname: Tian
authors.forename: Roger H
authors.initials: RH
authors.lastname: Johnson
authors.forename: Deirdre R
authors.initials: DR
authors.lastname: Meldrum