title: Posterior cortical atrophy with prominent alexia without agraphia in a Tourette syndrome.
abstract: We report for the first time a patient with childhood-onset Tourette's syndrome (TS) who developed alexia without agraphia, acalculia, visual agnosia for objects and faces, and preserved mnesic functions in older age. Neuroimaging studies demonstrated temporo-parieto-occipital cortical atrophy and fronto-temporo-parieto-occipital hypometabolism, both more prominent on the left side. This case fulfils the diagnostic criteria of posterior cortical atrophy (PCA). The possible link between TS and PCA is discussed.
authors.affiliation: Department of Neurological Sciences, Federico II University, Via Pansini 5, 80131 Naples, Italy.
authors.forename: Nina Antonetta
authors.initials: NA
authors.lastname: Fragassi
authors.forename: Laura
authors.initials: L
authors.lastname: Chiacchio
authors.forename: Luca
authors.initials: L
authors.lastname: Errichiello
authors.forename: Sabina
authors.initials: S
authors.lastname: Pappatà
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Tedeschi
authors.forename: Pasquale
authors.initials: P
authors.lastname: Striano
authors.forename: Salvatore
authors.initials: S
authors.lastname: Striano
mesh_terms: D000368:Aged; D020237:Alexia, Pure / Q000209:etiology*; D001284:Atrophy / Q000209:etiology; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000473:pathology*; D004569:Electroencephalography; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D049268:Positron-Emission Tomography; D005879:Tourette Syndrome / Q000150:complications*
chemical_list: D019788:Fluorodeoxyglucose F18