title: Diabetes alters cardiovascular responses to anaesthetic induction agents in STZ-diabetic rats.
abstract: BACKGROUND
  People with diabetes are at increased risk of cardiovascular (CV) morbidity and mortality during surgery. The most appropriate anaesthetic induction agent for these patients is unknown.
  
  
  RESULTS
  We assessed the CV effects of propofol, etomidate and ketamine in streptozotocin (65 mg/kg, IP) diabetic rats. In non-diabetic rats, none of these anaesthetics significantly modified cardiac output, heart rate or stroke volume, but ketamine increased systolic blood pressure (SBP) compared to etomidate and propofol (89.6 ± 2.4 mmHg, vs. 72.7 ± 3.0 and 75.4 ± 1.9; p < 0.05). In diabetic rats, by contrast, cardiac output was lower with ketamine (82.6 ± 14 ml/min) and etomidate (78.2 ± 15.8 ml/min) than with propofol (146 ± 21 ml/min, N = 8, p < 0.01). SBP, however, was higher in the propofol-treated group (93.3 ± 3.4 mmHg, p < 0.05).
  
  
  CONCLUSIONS
  These results suggest that hyperglycaemia modifies CV responses to induction anaesthetics.
authors.affiliation: Physiology Department, University of Puerto Rico-School of Medicine, San Juan, PR. maria.crespo3@upr.edu
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Crespo
authors.forename: Miguel
authors.initials: M
authors.lastname: Marrero
authors.forename: Nildris
authors.initials: N
authors.lastname: Cruz
authors.forename: Jose
authors.initials: J
authors.lastname: Quidgley
authors.forename: Osmar
authors.initials: O
authors.lastname: Creagh
authors.forename: Hector
authors.initials: H
authors.lastname: Torres
authors.forename: Karines
authors.initials: K
authors.lastname: Rivera
mesh_terms: D000777:Anesthetics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002302:Cardiac Output / Q000187:drug effects; D048909:Diabetes Complications / Q000209:etiology* / Q000503:physiopathology; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000150:complications*; D005045:Etomidate / Q000008:administration & dosage / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D007649:Ketamine / Q000008:administration & dosage / Q000494:pharmacology*; D015742:Propofol / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013318:Stroke Volume / Q000187:drug effects
chemical_list: D000777:Anesthetics; D001786:Blood Glucose; D007649:Ketamine; D015742:Propofol; D005045:Etomidate