title: A case of autoimmune hepatitis with Graves' disease treated by propylthiouracil.
abstract: A 58-year-old woman was referred to our hospital because of liver dysfunction. Her serum levels of AST (619 IU/l) and ALT (603 IU/l) had increased. Histological findings in the liver biopsy were compatible to autoimmune hepatitis (AIH), and the diagnosis of AIH was confirmed by the diagnostic criteria. She was admitted to a nearby hospital 3 years ago, and diagnosed with Graves' disease. She received methimazole (MMI) at first, which was discontinued due to liver injury in one month, then propylthiouracil (PTU) was administered. One year later, transaminase increased and was decreased by stopping PTU administration. PTU was restarted after her transaminase decreased, but a recurrence of hepatotoxicity was observed, and she was referred to our hospital. Oral prednisolone decreased liver function immediately. In this case, PTU-induced liver injury was suspected as a possible trigger of AIH. While PTU remains a commonly used drug in the treatment of hyperthyroidism, severe liver injury is reported in some cases. If liver injury is observed in patients treated with PTU, rechallenge is not recommended in order to avoid severe hepatotoxicity.
authors.affiliation: Department of Endocrinology and Diabetes, Tosei General Hospital, Japan. isato1204@gmail.com
authors.forename: Ikuko
authors.initials: I
authors.lastname: Sato
authors.forename: Taku
authors.initials: T
authors.lastname: Tsunekawa
authors.forename: Yuri
authors.initials: Y
authors.lastname: Shinohara
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Nishio
authors.forename: Yuko
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Shuko
authors.initials: S
authors.lastname: Yoshioka
mesh_terms: D013956:Antithyroid Agents / Q000009:adverse effects*; D005260:Female; D006111:Graves Disease / Q000188:drug therapy*; D019693:Hepatitis, Autoimmune / Q000209:etiology*; D006801:Humans; D008875:Middle Aged; D011441:Propylthiouracil / Q000009:adverse effects*
chemical_list: D013956:Antithyroid Agents; D011441:Propylthiouracil