title: MR-guided breast biopsy at 3T: diagnostic yield of large core needle biopsy compared with vacuum-assisted biopsy.
abstract: OBJECTIVE
  The purpose of this study was to evaluate two MR-guided biopsy techniques at 3 T, large core needle breast biopsy (LCNB) and vacuum-assisted breast biopsy (VAB) and to compare the diagnostic yield and rate of complications to determine the optimal biopsy technique at 3 T.
  
  
  METHODS
  55 LCNB and 64 VAB were consecutively performed. Benign biopsy results were verified by retrospective correlation of histology, with pre-interventional, post-interventional MRI studies and follow-up and were classified as representative or non-representative. Time to follow-up was up to 2 years for the considered non-representative benign lesions. Statistical analysis was performed using the Chi-squared test.
  
  
  RESULTS
  LCNB was technically successful in 100% of patients (55/55) and VAB in 98% of patients (63/64). Histopathological analysis resulted in 45 (82%) benign, 3 (5%) high-risk and 7 (13%) malignant lesions for LCNB and 43 (67%) benign, 3 (5%) high-risk and 18 (28%) malignant lesions. Distribution was significantly different (p < 0.001), favouring VAB over LCNB.
  
  
  CONCLUSIONS
  Because of the substantially higher diagnostic yield and certainty of a benign diagnosis, VAB is the optimal biopsy technique at 3 T. LCNB should be considered when VAB is not feasible.
authors.affiliation: Department of Radiology, Radboud University Nijmegen Medical Centre, Geert Grooteplein-Zuid 10, 6525GA Nijmegen, the Netherlands. carlameeuwis@gmail.com
authors.forename: Carla
authors.initials: C
authors.lastname: Meeuwis
authors.forename: Jeroen
authors.initials: J
authors.lastname: Veltman
authors.forename: Hester N
authors.initials: HN
authors.lastname: van Hall
authors.forename: Roel D M
authors.initials: RD
authors.lastname: Mus
authors.forename: Carla
authors.initials: C
authors.lastname: Boetes
authors.forename: Jelle O
authors.initials: JO
authors.lastname: Barentsz
authors.forename: Ritse M
authors.initials: RM
authors.lastname: Mann
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy / Q000379:methods*; D001707:Biopsy, Needle / Q000379:methods*; D001940:Breast / Q000473:pathology*; D004867:Equipment Design; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053783:Magnetic Resonance Imaging, Interventional / Q000379:methods*; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D011871:Radiology / Q000379:methods; D015203:Reproducibility of Results; D016896:Treatment Outcome; D014618:Vacuum