title: Simultaneous measurement of left and right ventricular volumes and ejection fraction during dobutamine stress cardiovascular magnetic resonance.
abstract: OBJECTIVE
  During cardiovascular stress, if right ventricular (RV) stroke volume exceeds left ventricular (LV) stroke volume, then a large volume of blood is displaced into the pulmonary circulation that may precipitate pulmonary edema. We sought to determine the metrics by which cardiovascular magnetic resonance (CMR) could measure simultaneous displacement of RV and LV stroke volumes during dobutamine stress.
  
  
  METHODS
  Thirteen healthy subjects (5 women) aged 53 ± 10 years without medical conditions and taking no medications underwent 2 CMR examinations at 1.5 T separated by 4 to 8 weeks in which RV and LV stroke volumes were determined during intravenous dobutamine and atropine infused to achieve 80% of the maximum predicted heart rate response for age.
  
  
  RESULTS
  The RV and LV stroke volumes were highly correlated at each level of stress (rest: r = 0.98, P = 0.007; low stress: r = 0.87, P = 0.001; and peak stress: r = 0.88, P = 0.001), and the mean difference in SV at each level of stress (rest, low stress, and peak stress was 0 to 2 mL on examinations 1 and 2.
  
  
  CONCLUSIONS
  Simultaneous change in right and left ventricular stroke volumes can be assessed in a highly reproducible manner throughout the course of dobutamine CMR stress administered to achieve 80% of maximum predicted heart rate response for age. This technology may help identify discrepancies in RV and LV stroke volumes during cardiovascular stress that are associated with the development of pulmonary edema.
authors.affiliation: Department of Internal Medicine (Cardiology Section), Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
authors.forename: Sangeeta
authors.initials: S
authors.lastname: Mandapaka
authors.forename: Craig A
authors.initials: CA
authors.lastname: Hamilton
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Morgan
authors.forename: William Gregory
authors.initials: WG
authors.lastname: Hundley
mesh_terms: D000328:Adult; D001285:Atropine; D002316:Cardiotonic Agents; D004280:Dobutamine; D005080:Exercise Test; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D013318:Stroke Volume / Q000502:physiology*; D016277:Ventricular Function, Left / Q000502:physiology*; D016278:Ventricular Function, Right / Q000502:physiology*
chemical_list: D002316:Cardiotonic Agents; D004280:Dobutamine; D001285:Atropine