title: Nonspecific interstitial pneumonia: prognostic significance of high-resolution computed tomography in 59 patients.
abstract: OBJECTIVE
  To retrospectively analyze the prognostic implications of high-resolution computed tomography (HRCT) findings for patients with biopsy-proven nonspecific interstitial pneumonia (NSIP).
  
  
  METHODS
  Fifty-nine patients with NSIP (25 idiopathic NSIP, 34 collagen-vascular disease-associated NSIP) were included. Two chest radiologists independently evaluated the extent, presence, and distribution of various HRCT findings. Cox hazards analysis was used to evaluate the relationship between HRCT findings and prognosis.
  
  
  RESULTS
  The 5-year survival rate was 83% and the 10-year survival rate was 66%. Univariate analysis revealed that the extent of areas with ground-glass attenuation without traction bronchi-bronchiolectasis and that of airs-pace consolidation were associated with favorable outcome, whereas that of intralobular reticular opacities was associated with worse prognosis. Multivariate analysis showed that the extent of air-space consolidation was an independent factor of favorable outcome.
  
  
  CONCLUSIONS
  In NSIP, the extent of areas with ground-glass attenuation without traction bronchi-bronchiolectasis, air-space consolidation, and intralobular reticular opacities correlate with survival.
authors.affiliation: The Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Handayama Higashiku, Hamamatsu, Japan.
authors.forename: Hironao
authors.initials: H
authors.lastname: Hozumi
authors.forename: Yutaro
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Johkoh
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Sumikawa
authors.forename: Thomas V
authors.initials: TV
authors.lastname: Colby
authors.forename: Masato
authors.initials: M
authors.lastname: Karayama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hayakawa
authors.forename: Koushi
authors.initials: K
authors.lastname: Yokomura
authors.forename: Shiro
authors.initials: S
authors.lastname: Imokawa
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Yasuda
authors.forename: Mikio
authors.initials: M
authors.lastname: Toyoshima
authors.forename: Hideki
authors.initials: H
authors.lastname: Suganuma
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Shirai
authors.forename: Naoki
authors.initials: N
authors.lastname: Inui
authors.forename: Takafumi
authors.initials: T
authors.lastname: Suda
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Nakamura
authors.forename: Kingo
authors.initials: K
authors.lastname: Chida
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D015996:Survival Rate; D014057:Tomography, X-Ray Computed / Q000379:methods*