title: Cardiac rehabilitation decreases plasma pentraxin 3 in patients with cardiovascular diseases.
abstract: BACKGROUND
  Inflammatory markers such as serum C-reactive protein (CRP), serum amyloid A (SAA), and plasma pentraxin 3 (PTX3), which belong to the pentraxin superfamily, increase due to various inflammatory diseases. Some studies demonstrated that serum CRP and SAA are predictors of cardiovascular diseases, and cardiac rehabilitation (CR) induces anti-inflammatory effects. In the present study, we investigated the effects of CR on pentraxins (serum CRP, SAA, and plasma PTX3) in patients with cardiovascular diseases.
  
  
  METHODS
  Fifty patients with cardiovascular diseases [61 ± 13 (mean ± SD) years old, male/female 44/6] participated. Each subject performed CR using aerobic bicycle exercise two or three times per week for 3-6 months. We measured resting serum high-sensitivity CRP (hsCRP), SAA, and plasma PTX3 before and 3 and 6 months after CR, and compared them with VO(2peak) determined using a standard increment cycle ergometer protocol, B-type natriuretic peptide (BNP), and other biochemical data such as HbA1c.
  
  
  RESULTS
  There was a significant positive correlation between hsCRP and SAA (r = 0.92, p < 0.001), but no relations between these parameters and PTX3. Plasma PTX3 significantly decreased time dependently during CR (at baseline 3.2 ± 2.0 ng/ml, at 3 months 2.3 ± 0.8 ng/ml, at 6 months 2.1 ± 0.7 ng/ml; all p < 0.05). Serum hsCRP tended to decrease, but not statistically significantly. At baseline, plasma PTX3 was negatively correlated with the percentage of the predicted values of VO(2peak) and positively correlated with BNP. CR significantly increased the percentage of the predicted values of VO(2peak) and decreased BNP.
  
  
  CONCLUSIONS
  Plasma PTX3, an inflammatory marker, which was quite different from CRP and SAA, decreased during cardiac rehabilitation with an improvement of exercise capacity in patients with cardiovascular diseases.
authors.affiliation: Department of Ischemic Circulatory Physiology, University of Tokyo, Tokyo, Japan.
authors.forename: Taira
authors.initials: T
authors.lastname: Fukuda
authors.forename: Miwa
authors.initials: M
authors.lastname: Kurano
authors.forename: Haruko
authors.initials: H
authors.lastname: Iida
authors.forename: Haruhito
authors.initials: H
authors.lastname: Takano
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Tanaka
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Kenichi
authors.initials: K
authors.lastname: Ikeda
authors.forename: Mika
authors.initials: M
authors.lastname: Nagasaki
authors.forename: Koshiro
authors.initials: K
authors.lastname: Monzen
authors.forename: Kansei
authors.initials: K
authors.lastname: Uno
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kato
authors.forename: Taro
authors.initials: T
authors.lastname: Shiga
authors.forename: Koji
authors.initials: K
authors.lastname: Maemura
authors.forename: Nobuhito
authors.initials: N
authors.lastname: Masuda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamashita
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Hirata
authors.forename: Ryozo
authors.initials: R
authors.lastname: Nagai
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Nakajima
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D000072038:Cardiac Rehabilitation; D002318:Cardiovascular Diseases / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D016009:Chi-Square Distribution; D015536:Down-Regulation; D005080:Exercise Test; D005081:Exercise Therapy; D017079:Exercise Tolerance; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010101:Oxygen Consumption; D020127:Recovery of Function; D000685:Serum Amyloid A Protein / Q000378:metabolism; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D013997:Time Factors; D016896:Treatment Outcome; D000099153:Pentraxins
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D006442:Glycated Hemoglobin; D018836:Inflammation Mediators; D020097:Natriuretic Peptide, Brain; D000685:Serum Amyloid A Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins; C517652:hemoglobin A1c protein, human