title: The importance of antioxidant micronutrients in pregnancy.
abstract: Pregnancy places increased demands on the mother to provide adequate nutrition to the growing conceptus. A number of micronutrients function as essential cofactors for or themselves acting as antioxidants. Oxidative stress is generated during normal placental development; however, when supply of antioxidant micronutrients is limited, exaggerated oxidative stress within both the placenta and maternal circulation occurs, resulting in adverse pregnancy outcomes. The present paper summarises the current understanding of selected micronutrient antioxidants selenium, copper, zinc, manganese, and vitamins C and E in pregnancy. To summarise antioxidant activity of selenium is via its incorporation into the glutathione peroxidase enzymes, levels of which have been shown to be reduced in miscarriage and preeclampsia. Copper, zinc, and manganese are all essential cofactors for superoxide dismutases, which has reduced activity in pathological pregnancy. Larger intervention trials are required to reinforce or refute a beneficial role of micronutrient supplementation in disorders of pregnancies.
authors.affiliation: Division of Women's Health, Maternal and Fetal Research Unit, King's College London, St. Thomas' Hospital, UK.
authors.forename: Hiten D
authors.initials: HD
authors.lastname: Mistry
authors.forename: Paula J
authors.initials: PJ
authors.lastname: Williams
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D005260:Female; D005979:Glutathione Peroxidase / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D018977:Micronutrients / Q000378:metabolism*; D018384:Oxidative Stress; D011247:Pregnancy; D013482:Superoxide Dismutase / Q000737:chemistry / Q000378:metabolism
chemical_list: D000975:Antioxidants; D018977:Micronutrients; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase