title: Stereoselective synthesis and rearrangement-fragmentation of arylidene N-alkoxydiketopiperazines.
abstract: A stereoselective synthesis of arylidene N-alkoxydiketopiperazines via oxime-ether formation and intramolecular acylation is described, followed by an acid-catalysed rearrangement-fragmentation to give novel diketopiperazine hemiaminal derivatives with useful bioactivity against certain tumour cell lines.
authors.affiliation: State Key Laboratory Breeding Base-Hebei Province Key Laboratory of Molecular Chemistry for Drug, Hebei University of Science & Technology, Shijiazhuang 050018, People's Republic of China. shouxin.liu@durham.ac.uk
authors.forename: Shouxin
authors.initials: S
authors.lastname: Liu
authors.forename: Yun
authors.initials: Y
authors.lastname: Mu
authors.forename: Jianrong
authors.initials: J
authors.lastname: Han
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Zhen
authors.forename: Yihua
authors.initials: Y
authors.lastname: Yang
authors.forename: Xia
authors.initials: X
authors.lastname: Tian
authors.forename: Andrew
authors.initials: A
authors.lastname: Whiting
mesh_terms: D018360:Crystallography, X-Ray; D054659:Diketopiperazines / Q000138:chemical synthesis* / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D013237:Stereoisomerism
chemical_list: D054659:Diketopiperazines