title: [Intestinal inflammation-induced child growth failure: immunologic and endocrine mechanisms].
abstract: Faltering linear growth is commonly encountered in children with intestinal inflammation. Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are important regulators of postnatal longitudinal bone growth. Inhibition of GH/IGF axis will result in growth failure in young children. Pro-inflammatory cytokines such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) abnormally increase in children with intestinal inflammation, and may affect linear growth both systemically and locally at the level of the growth plate though disturbing the GH/IGF axis.
authors.affiliation: Department of Child and Adolescent Health Care, Shanghai Jiao Tong University School of Medicine, China.
authors.forename: Jing-Qiu
authors.initials: JQ
authors.lastname: Ma
authors.forename: Xiao-Yang
authors.initials: XY
authors.lastname: Sheng
mesh_terms: D001846:Bone Development; D016207:Cytokines / Q000502:physiology; D004751:Enteritis / Q000150:complications*; D006130:Growth Disorders / Q000209:etiology*; D019382:Human Growth Hormone / Q000502:physiology; D006801:Humans; D013002:Somatomedins / Q000502:physiology
chemical_list: D016207:Cytokines; D013002:Somatomedins; D019382:Human Growth Hormone