title: Labor induction in term premature rupture of membranes: comparison between oxytocin and dinoprostone followed 6 hours later by oxytocin.
abstract: OBJECTIVE
  The aim of this randomized study was to compare 2 protocols for inducing labor in women with premature rupture of membranes (PROM) at term.
  
  
  METHODS
  Women with PROM and a Bishop score ≤5 were randomly assigned to receive either an intravenous oxytocin infusion (n = 223) or a dinoprostone pessary followed 6 hours later by an intravenous oxytocin infusion (n = 227).
  
  
  RESULTS
  Vaginal delivery within 24 hours of labor induction increased significantly with sustained-released dinoprostone followed by oxytocin infusion (78.5% vs 63.3%; relative risk, 1.23; 95% confidence interval, 1.09-1.39; P = .001). Maternal and neonatal outcomes were similar between the groups.
  
  
  CONCLUSIONS
  Sustained-released dinoprostone followed 6 hours later by an oxytocin infusion in term women with PROM was associated with a higher rate of vaginal delivery within 24 hours, and no difference in maternal-neonatal complications was observed compared with oxytocin infusion alone.
authors.affiliation: Mardin Women's and Children's Hospital, Mardin, Turkey. maidenkemal@yahoo.com
authors.forename: Kemal
authors.initials: K
authors.lastname: Güngördük
authors.forename: Osman
authors.initials: O
authors.lastname: Asicioglu
authors.forename: Berhan
authors.initials: B
authors.lastname: Besimoglu
authors.forename: Ozgu Celikkol
authors.initials: OC
authors.lastname: Güngördük
authors.forename: Gokhan
authors.initials: G
authors.lastname: Yildirm
authors.forename: Cemal
authors.initials: C
authors.lastname: Ark
authors.forename: Ahmet
authors.initials: A
authors.lastname: Sahbaz
mesh_terms: D000328:Adult; D015232:Dinoprostone / Q000008:administration & dosage*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000503:physiopathology*; D006801:Humans; D007751:Labor, Induced / Q000379:methods*; D010120:Oxytocics / Q000008:administration & dosage*; D010121:Oxytocin / Q000008:administration & dosage*; D011247:Pregnancy; D011256:Pregnancy Outcome; D055815:Young Adult
chemical_list: D010120:Oxytocics; D010121:Oxytocin; D015232:Dinoprostone