title: Enamine/Carbene Cascade Catalysis in the Diastereo- and Enantioselective Synthesis of Functionalized Cyclopentanones.
abstract: Herein we report an enantioselective synthesis of complex cyclopentanones using aliphatic aldehydes and activated enones. With the combination of a chiral secondary amine and a chiral triazolium catalyst, high diastereoselectivity and excellent enantioselectivity can be achieved. We present evidence of a clear cooperative effect when these two catalysts are present simultaneously in the system.
authors.affiliation: Department of Chemistry, Colorado State University, Fort Collins, Colorado, USA.
authors.forename: Kerem E
authors.initials: KE
authors.lastname: Ozboya
authors.forename: Tomislav
authors.initials: T
authors.lastname: Rovis