title: [Gap junction intercellular communication in carcinogenesis of endometrial cancer].
abstract: One of the mechanisms for direct cell to cell signaling is mediated by gap junctions. These junctions are formed by connexins, transmembrane proteins. Gap junction intercellular communication (GJIC) plays a critical role in tissue development, differentiation of cells, and regulation of tissue homeostasis. Cancer cells are characterized by growth and/or differentiation disorders. Endometrial cancer is the most common gynecological malignancy in developed countries. In this study we discuss the putative role of GJIC and adhesion molecules in the development of endometrial cancer The relationships of GJIC to the process of apoptosis and function of some adhesion proteins have also been underlined.
authors.affiliation: Zakład Patomorfologii Ogólnej Uniwersytetu Medycznego w Białymstoku, Polska.
authors.forename: Marek
authors.initials: M
authors.lastname: Baltaziak
authors.forename: Luiza
authors.initials: L
authors.lastname: Kańczuga-Koda
authors.forename: Ryszard
authors.initials: R
authors.lastname: Rutkowski
authors.forename: Marcin
authors.initials: M
authors.lastname: Musiatowicz
authors.forename: Mariusz
authors.initials: M
authors.lastname: Koda
authors.forename: Ryszard
authors.initials: R
authors.lastname: Leśniewicz
authors.forename: Urszula
authors.initials: U
authors.lastname: Sulkowska
authors.forename: Monika
authors.initials: M
authors.lastname: Baltaziak
authors.forename: Tomasz
authors.initials: T
authors.lastname: Leśniewicz
authors.forename: Stanisław
authors.initials: S
authors.lastname: Sulkowski
mesh_terms: D002450:Cell Communication; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D017630:Connexins / Q000378:metabolism*; D016889:Endometrial Neoplasms / Q000378:metabolism*; D005260:Female; D017629:Gap Junctions / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction
chemical_list: D017630:Connexins