title: Increased prevalence of cardiovascular risk factors in patients with acute coronary syndrome and indications for treatment with oral anticoagulation.
abstract: BACKGROUND
  Antiplatelet drugs currently constitute the basic treatment of coronary artery disease (acute coronary syndrome [ACS], stable angina and patients treated with percutaneous coronary interventions [PCI]). The number of patients with indication for dual antiplatelet therapy with comorbidities with high thrombo-embolic risk (such as atrial fibrillation [AF], venous thrombotic disease, valvular diseases) is increasing. That is why the need for simultaneous administration of dual antiplatelet and oral anticoagulant therapy (triple therapy) has become more common recently. The AF is the most common indication for chronic anticoagulation. Because of the lack of large randomised trials regarding triple therapy, characteristics of this group has not been well established.
  
  
  OBJECTIVE
  To assess the presence of cardiovascular (CV) risk factors and concomitant diseases in patients with ACS requiring triple therapy.
  
  
  METHODS
  Retrospective analysis included 2279 patients diagnosed with ACS who were admitted to the Departments of Cardiology in Cracow in 2008. In this group, 365 (16%) patients had indications for chronic anticoagulation. Demographic and clinical characteristics of these patients were compared with those of patients included in other published registries.
  
  
  RESULTS
  Patients requiring triple therapy were aged 73.2 ± 9.5 years. Hypertension was diagnosed in 80%, hyperlipidaemia in 63%, smoking in 36%, prior myocardial infarction in 33%, prior stroke in 15%, previous treatment with PCI in 13%, coronary artery bypass grafting in 7%, diabetes in 36%, heart failure in 46%, anaemia in 33% and chronic ulcer disease or gastroesophageal reflux disease in 9%. The mean left ventricular ejection fraction was 46 ± 15%. Compared with other registries of patients without indications for triple therapy, our patients had significantly more frequently hypertension, diabetes and were older.
  
  
  CONCLUSIONS
  Patients after an ACS requiring triple therapy have more often a history of comorbidities and CV risk factors when compared with the group of patients with ACS without indication for triple therapy.
authors.affiliation: Department of Cardiology, J. Dietl Hospital, Krakow, Poland. michalo@op.pl
authors.forename: Michał
authors.initials: M
authors.lastname: Owsiak
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Pelc-Nowicka
authors.forename: Leszek
authors.initials: L
authors.lastname: Badacz
authors.forename: Jacek
authors.initials: J
authors.lastname: Dubiel
authors.forename: Dariusz
authors.initials: D
authors.lastname: Dudek
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Gajos
authors.forename: Janusz
authors.initials: J
authors.lastname: Grodecki
authors.forename: Piotr
authors.initials: P
authors.lastname: Jankowski
authors.forename: Kalina
authors.initials: K
authors.lastname: Kawecka-Jaszcz
authors.forename: Ewa
authors.initials: E
authors.lastname: Mirek-Bryniarska
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Nessler
authors.forename: Piotr
authors.initials: P
authors.lastname: Podolec
authors.forename: Jerzy
authors.initials: J
authors.lastname: Sadowski
authors.forename: Wiesława
authors.initials: W
authors.lastname: Tracz
authors.forename: Michał
authors.initials: M
authors.lastname: Zabojszcz
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Żmudka
authors.forename: Leszek
authors.initials: L
authors.lastname: Bryniarski
mesh_terms: D054058:Acute Coronary Syndrome / Q000188:drug therapy*; D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors