title: Excision repair cross complementation group 1 polymorphisms and lung cancer risk: a meta-analysis.
abstract: BACKGROUND
  Several studies have evaluated the association between polymorphisms of encoding excision repair cross complementation group 1 (ERCC1) enzyme and lung cancer risk in diverse populations but with conflicting results. By pooling the relatively small samples in each study, it is possible to perform a meta-analysis of the evidence by rigorous methods.
  
  
  METHODS
  Embase, Ovid, Medline and Chinese National Knowledge Infrastructure were searched. Additional studies were identified from references in original studies or review articles. Articles meeting the inclusion criteria were reviewed systematically, and the reported data were aggregated using the statistical techniques of meta-analysis.
  
  
  RESULTS
  We found 3810 cases with lung cancer and 4332 controls from seven eligible studies. T19007C polymorphism showed no significant effect on lung cancer risk (C allele vs. T allele: odds ratio (OR) = 0.91, 95% confidence interval (CI) = 0.80 - 1.04; CC vs. TT: OR = 0.76, 95%CI = 0.56 - 1.02; CC vs. (CT + TT): OR = 0.96, 95%CI = 0.84 - 1.10). Similarly, there was no significant main effects for T19007C polymorphism on lung cancer risk when stratified analyses by ethnicity (Chinese or Caucasian). No significant association was found between C8092A polymorphism (3060 patients and 2729 controls) and the risk of lung cancer (A allele vs. C allele: OR = 1.03, 95%CI = 0.95 - 1.11; AA vs. CC: OR = 1.08, 95%CI = 0.88 - 1.33; AA vs. (AC + CC): OR = 1.08, 95%CI = 0.88 - 1.31).
  
  
  CONCLUSIONS
  We found little evidence of an association between the T1900C or C8092A polymorphisms of ERCC 1 and the risk of lung cancer in Caucasian or Han Chinese people.
authors.affiliation: Department of Respiratory Medicine, Affiliated Hospital of School of Medicine, Ningbo University, Ningbo, Zhejiang 315020, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Cao
authors.forename: Yan-mei
authors.initials: YM
authors.lastname: Zhang
authors.forename: Ran
authors.initials: R
authors.lastname: Wang
authors.forename: Shi-fang
authors.initials: SF
authors.lastname: Sun
authors.forename: Zhong-bo
authors.initials: ZB
authors.lastname: Chen
authors.forename: Hong-ying
authors.initials: HY
authors.lastname: Ma
authors.forename: Yi-ming
authors.initials: YM
authors.lastname: Yu
authors.forename: Qun-li
authors.initials: QL
authors.lastname: Ding
authors.forename: Li-hua
authors.initials: LH
authors.lastname: Shu
authors.forename: Zai-chun
authors.initials: ZC
authors.lastname: Deng
mesh_terms: D044466:Asian People / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D004720:Endonucleases / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; C071447:ERCC1 protein, human; D004720:Endonucleases