title: Synthesis of cytimidine through a one-pot copper-mediated amidation cascade.
abstract: A concise synthesis of cytimidine was developed utilizing tandem Cu-mediated N-aryl amidations followed by global deprotection. This sequence exploits a regioselective coupling of an iodobenzamide with a halopyrimidine that allows the union of three fragments in a single synthetic manipulation and will permit the efficient and rapid diversification of the cytimidine core.
authors.affiliation: Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, USA.
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Serrano
authors.forename: Ryan E
authors.initials: RE
authors.lastname: Looper
mesh_terms: D000586:Amination; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D011744:Pyrimidinones / Q000138:chemical synthesis*
chemical_list: D011744:Pyrimidinones; C569207:cytimidine; D003300:Copper