title: IL-17F deficiency inhibits small intestinal tumorigenesis in ApcMin/+ mice.
abstract: IL-17 plays an important role in gut homeostasis. However, the role of IL-17F in intestinal tumorigenesis has not been addressed. Here we demonstrate that ablation of IL-17F significantly inhibits spontaneous intestinal tumorigenesis in the small intestine of Apc(Min/+) mice. IL-17F ablation decreased IL-1β and Cox-2 expression as well as IL-17 receptor C (IL-17RC) expression, which were increased in tumors from Apc(Min/+) mice. Lack of IL-17F did not reverse the splenomegaly but partially restored thymic atrophy, suggesting a local effect of IL-17F in the intestine. IL-17F deficient Apc(Min/+) mice showed a significant decrease in immune cell infiltration in the lamina propria. Interestingly, the expression of IL-17A from CD4 T cells in the lamina propria remains unchanged in the absence of IL-17F. Collectively, our results suggest the proinflammatory and essential role of IL-17F to develop spontaneous intestinal tumorigenesis in Apc(Min/+) mice in the presence of IL-17A.
authors.affiliation: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
authors.forename: Wook-Jin
authors.initials: WJ
authors.lastname: Chae
authors.forename: Alfred L M
authors.initials: AL
authors.lastname: Bothwell
mesh_terms: D000818:Animals; D001284:Atrophy / Q000235:genetics / Q000276:immunology; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000276:immunology*; D017491:Genes, APC; D020381:Interleukin-17 / Q000235:genetics / Q000502:physiology*; D053583:Interleukin-1beta / Q000037:antagonists & inhibitors / Q000276:immunology; D007414:Intestinal Neoplasms / Q000235:genetics / Q000276:immunology*; D007421:Intestine, Small / Q000276:immunology* / Q000473:pathology; D051379:Mice; D018345:Mice, Knockout; D013163:Splenomegaly / Q000235:genetics / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology / Q000473:pathology
chemical_list: C515932:Il17f protein, mouse; D020381:Interleukin-17; D053583:Interleukin-1beta