title: Biochemical characterization of the TEM-107 extended-spectrum β-lactamase in a Klebsiella pneumoniae isolate from South Korea.
abstract: The TEM-107 extended-spectrum β-lactamase detected in a Klebsiella pneumoniae clinical isolate had a Gly238Ser substitution compared to the TEM-43 β-lactamase. The MIC of ceftazidime was higher (64 μg/ml) than that of cefotaxime (2 μg/ml) for the isolate. Clavulanic acid reduced the MIC of ceftazidime 64-fold.
authors.affiliation: Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Kyungwon
authors.initials: K
authors.lastname: Lee
authors.forename: Jong Hwa
authors.initials: JH
authors.lastname: Yum
authors.forename: Dongeun
authors.initials: D
authors.lastname: Yong
authors.forename: Seok Hoon
authors.initials: SH
authors.lastname: Jeong
authors.forename: Gian Maria
authors.initials: GM
authors.lastname: Rossolini
authors.forename: Jean-Denis
authors.initials: JD
authors.lastname: Docquier
authors.forename: Yunsop
authors.initials: Y
authors.lastname: Chong
mesh_terms: D000293:Adolescent; D019943:Amino Acid Substitution; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002439:Cefotaxime / Q000494:pharmacology; D002442:Ceftazidime / Q000494:pharmacology; D019818:Clavulanic Acid / Q000494:pharmacology; D003227:Conjugation, Genetic; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics; D005260:Female; D006801:Humans; D007700:Kinetics; D007710:Klebsiella Infections / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology* / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests / Q000592:standards; D056910:Republic of Korea; D018440:beta-Lactam Resistance / Q000235:genetics; D001618:beta-Lactamases / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D019818:Clavulanic Acid; D002442:Ceftazidime; C114617:beta-lactamase TEM-43; D001618:beta-Lactamases; D002439:Cefotaxime