title: miRNAs in lung cancer: large roles for small players.
abstract: miRNAs play an important role in the regulation of a wide assortment of cellular processes by sequestering target mRNAs and inhibiting translation of the proteins that they encode. Multiple miRNAs can regulate single mRNA molecules and, alternatively, a single miRNA can act on a number of mRNA targets. Dysfunctional miRNAs are commonly found in a variety of solid cancers and are attractive candidates for next-generation therapeutics. This article highlights miRNA signatures proposed for lung cancer classification and diagnosis, chemo- and radio-therapy resistance, metastasis and prediction of treatment outcome and survival.
authors.affiliation: The Translational Genomics Research Institute, Phoenix, AZ, USA.
authors.forename: Irene
authors.initials: I
authors.lastname: Cherni
authors.forename: Glen J
authors.initials: GJ
authors.lastname: Weiss
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D055088:Early Detection of Cancer; D020869:Gene Expression Profiling; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality / Q000628:therapy; D035683:MicroRNAs / Q000032:analysis* / Q000378:metabolism / Q000627:therapeutic use; D009362:Neoplasm Metastasis; D011379:Prognosis; D011836:Radiation Tolerance / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs