title: Severe deterioration of newly diagnosed Takayasu arteritis in a patient re-treated with interferon beta-1α for concomitant longstanding multiple sclerosis.
abstract: A 52-year-old woman with Takayasu arteritis and a known history of multiple sclerosis had been treated with subcutaneous interferon (IFN) beta-1α. After the re-introduction of the IFN beta-1α, the patient had a gradual worsening of the arteritis, with claudication symptoms in the left arm and increased inflammation markers. An evaluation using Doppler ultrasound of the supra-aortic vessels revealed severe stenosis of the left axillary artery. The IFN beta-1α was withdrawn, with prompt clinical and laboratory improvement of the vasculitis.
authors.affiliation: Department of Rheumatology, Hospital of Southern Norway, Service box 416, 4604 Kristiansand, Norway. andreas.diamantopoulos@sshf.no
authors.forename: Andreas P
authors.initials: AP
authors.lastname: Diamantopoulos
authors.forename: Helene
authors.initials: H
authors.lastname: Hetland
authors.forename: Atle E
authors.initials: AE
authors.lastname: Hansen
authors.forename: Geirmund
authors.initials: G
authors.lastname: Myklebust
mesh_terms: D001366:Axillary Artery / Q000000981:diagnostic imaging; D003251:Constriction, Pathologic / Q000000981:diagnostic imaging; D018450:Disease Progression; D005260:Female; D006801:Humans; D000068556:Interferon beta-1a; D016899:Interferon-beta / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D019233:Retreatment; D013625:Takayasu Arteritis / Q000139:chemically induced* / Q000150:complications / Q000000981:diagnostic imaging; D014463:Ultrasonography
chemical_list: D016899:Interferon-beta; D000068556:Interferon beta-1a