title: Affecting cognition and quality of life via aerobic exercise in Alzheimer's disease.
abstract: Aerobic exercise is a promising behavioral therapy for Alzheimer's disease (AD), yet few studies have investigated the effect of aerobic exercise on cognition in AD. The purpose of this pilot study was to examine the effect of 6-month aerobic exercise on the change in executive function, global cognition, quality of life (QOL), and depression in community-dwelling older adults with mild to moderate AD. A single group, repeated measures design with outcomes measured at baseline, 3 months, and 6 months was used. Results show that there were no significant changes in any measures except for depression (p = .026). There was a trend toward improvement in executive function and QOL with moderate effect sizes (ESs) and a trend toward deterioration in global cognition with moderate to large ESs. Randomized controlled trials are needed to evaluate the therapeutic effect of aerobic exercise in older adults with AD.
authors.affiliation: University of Minnesota School of Nursing, Minneapolis 55455, USA. yuxxx244@umn.edu
authors.forename: Fang
authors.initials: F
authors.lastname: Yu
authors.forename: Nathaniel W
authors.initials: NW
authors.lastname: Nelson
authors.forename: Kay
authors.initials: K
authors.lastname: Savik
authors.forename: Jean F
authors.initials: JF
authors.lastname: Wyman
authors.forename: Maurice
authors.initials: M
authors.lastname: Dysken
authors.forename: Ulf G
authors.initials: UG
authors.lastname: Bronas
mesh_terms: D000544:Alzheimer Disease / Q000503:physiopathology* / Q000523:psychology; D003071:Cognition; D015444:Exercise; D006801:Humans; D010865:Pilot Projects; D011788:Quality of Life