title: Flow cytometric phenotyping and analysis of T regulatory cells in multiple myeloma patients.
abstract: Multiple myeloma (MM) is a plasma cell (PC) disorder and associated with immune impairments. Flow cytometry based phenotyping and quantification of regulatory T cells (Tregs) enable to monitor the immune status of myeloma patients. Apart from enumeration of Tregs, functional characterization using proliferation or suppression assay adds key value in demonstrating the functional value ofTregs. Our study revealed that in MM patientsTregs are elevated compared to healthy subjects, which demonstrate the immune deregulation in MM.
authors.affiliation: Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
authors.forename: K R
authors.initials: KR
authors.lastname: Muthu Raja
authors.forename: L
authors.initials: L
authors.lastname: Kovárová
authors.forename: J
authors.initials: J
authors.lastname: Stossová
authors.forename: R
authors.initials: R
authors.lastname: Hájek
mesh_terms: D005434:Flow Cytometry; D006801:Humans; D016130:Immunophenotyping; D009101:Multiple Myeloma / Q000276:immunology* / Q000628:therapy; D050378:T-Lymphocytes, Regulatory / Q000145:classification / Q000276:immunology*