title: Malignant pirates of the immune system.
abstract: At great human cost, cancer is the largest genetic experiment ever conducted. This review highlights how lymphoid malignancies have genetically perverted normal immune signaling and regulatory mechanisms for their selfish oncogenic goals of unlimited proliferation, perpetual survival and evasion of the immune response.
authors.affiliation: Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Lixin
authors.initials: L
authors.lastname: Rui
authors.forename: Roland
authors.initials: R
authors.lastname: Schmitz
authors.forename: Michele
authors.initials: M
authors.lastname: Ceribelli
authors.forename: Louis M
authors.initials: LM
authors.lastname: Staudt
mesh_terms: D000818:Animals; D051925:CD79 Antigens / Q000235:genetics; D004268:DNA-Binding Proteins / Q000502:physiology; D006801:Humans; D007107:Immune System / Q000502:physiology*; D050835:Interferon Regulatory Factors / Q000502:physiology; D053614:Janus Kinase 2 / Q000502:physiology; D008223:Lymphoma / Q000276:immunology*; D053594:Myeloid Differentiation Factor 88 / Q000235:genetics; D009857:Oncogenes; D051560:Proto-Oncogene Proteins c-bcl-6; D015398:Signal Transduction; D014157:Transcription Factors / Q000502:physiology; D000099218:Interferon Regulatory Factor-4
chemical_list: D051925:CD79 Antigens; D004268:DNA-Binding Proteins; D050835:Interferon Regulatory Factors; D053614:Janus Kinase 2; D053594:Myeloid Differentiation Factor 88; D051560:Proto-Oncogene Proteins c-bcl-6; D014157:Transcription Factors; D000099218:Interferon Regulatory Factor-4; C084103:BCL6 protein, human; C507924:JAK2 protein, human