title: Autoantibody formation in human and rat studies of chronic rejection and primary graft dysfunction.
abstract: Lung transplantation is considered a definitive treatment for many lung diseases. However, rejection and other pathologic entities are major causes of morbidity and mortality for lung transplant recipients. Primary graft dysfunction (PGD) and obliterative bronchiolitis (OB) are the leading causes of early and late mortality, respectively. While the immune basis of PGD has not been clearly defined, evidence is emerging about roles for autoantibodies in this process. Similarly, the pathogenesis of OB has been linked recently to autoimmunity. This review will highlight the current understanding of autoantibodies in PGD and OB post lung transplantation.
authors.affiliation: Center for Immunobiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. dwilkes@iupui.edu
authors.forename: David S
authors.initials: DS
authors.lastname: Wilkes
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis* / Q000276:immunology; D001989:Bronchiolitis Obliterans / Q000276:immunology; D002908:Chronic Disease; D004195:Disease Models, Animal; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D016040:Lung Transplantation / Q000276:immunology*; D051379:Mice; D055031:Primary Graft Dysfunction / Q000276:immunology*; D051381:Rats
chemical_list: D001323:Autoantibodies