title: Classification trees based on infrared spectroscopic data to discriminate between genuine and counterfeit medicines.
abstract: Classification trees built with the Classification And Regression Tree algorithm were evaluated for modelling infrared spectroscopic data in order to discriminate between genuine and counterfeit drug samples and to classify counterfeit samples in different classes following the RIVM classification system. Models were built for two data sets consisting of the Fourier Transformed Infrared spectra, the near infrared spectra and the Raman spectra for genuine and counterfeit samples of respectively Viagra(®) and Cialis(®). Easy interpretable models were obtained for both models. The models were validated for their descriptive and predictive properties. The predictive properties were evaluated using both cross validation as an external validation set. The obtained models for both data sets showed a 100% correct classification for the discrimination between genuine and counterfeit samples and 83.3% and 100% correct classification for the counterfeit samples for the Viagra(®) and the Cialis(®) data set respectively.
authors.affiliation: Division of Food, Medicines and Consumer Safety, Section Medicinal Products, Scientific Institute of Public Health (IPH), J. Wytmansstraat 14, B-1050 Brussels, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Deconinck
authors.forename: P Y
authors.initials: PY
authors.lastname: Sacré
authors.forename: D
authors.initials: D
authors.lastname: Coomans
authors.forename: J
authors.initials: J
authors.lastname: De Beer
mesh_terms: D000465:Algorithms; D058110:Counterfeit Drugs; D017550:Spectroscopy, Fourier Transform Infrared; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D013059:Spectrum Analysis, Raman / Q000379:methods
chemical_list: D058110:Counterfeit Drugs