title: Adhesion of osteoblasts to a nanorough titanium implant surface.
abstract: This work considers the adhesion of cells to a nanorough titanium implant surface with sharp edges. The basic assumption was that the attraction between the negatively charged titanium surface and a negatively charged osteoblast is mediated by charged proteins with a distinctive quadrupolar internal charge distribution. Similarly, cation-mediated attraction between fibronectin molecules and the titanium surface is expected to be more efficient for a high surface charge density, resulting in facilitated integrin mediated osteoblast adhesion. We suggest that osteoblasts are most strongly bound along the sharp convex edges or spikes of nanorough titanium surfaces where the magnitude of the negative surface charge density is the highest. It is therefore plausible that nanorough regions of titanium surfaces with sharp edges and spikes promote the adhesion of osteoblasts.
authors.affiliation: Institute of General Electrical Engineering, University of Rostock, Rostock, Germany.
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Gongadze
authors.forename: Doron
authors.initials: D
authors.lastname: Kabaso
authors.forename: Sebastian
authors.initials: S
authors.lastname: Bauer
authors.forename: Tomaž
authors.initials: T
authors.lastname: Slivnik
authors.forename: Patrik
authors.initials: P
authors.lastname: Schmuki
authors.forename: Ursula
authors.initials: U
authors.lastname: van Rienen
authors.forename: Aleš
authors.initials: A
authors.lastname: Iglič
mesh_terms: D002448:Cell Adhesion; D006801:Humans; D008954:Models, Biological; D050997:Nanomedicine; D049329:Nanostructures / Q000737:chemistry / Q000648:ultrastructure; D016348:Osseointegration / Q000502:physiology; D010006:Osteoblasts / Q000166:cytology* / Q000502:physiology*; D019736:Prostheses and Implants; D011485:Protein Binding; D055672:Static Electricity; D013499:Surface Properties; D014025:Titanium
chemical_list: D014025:Titanium