title: Neutralizing effects of Nectandra angustifolia extracts against Bothrops neuwiedi snake venom.
abstract: Leaves extracts and essential oil of Nectandra angustifolia were explored for the first time for neutralization of Bothrops neuwiedi diporus snake venom. The ethanol extract was the most active and inhibited both venom activities (hemolytic and coagulant), while the oil was only active on the coagulant activity. These observations confirmed that certain medicinal plants from Corrientes and Chaco Provinces possess significant snake venom neutralizing capacity and need further examination for their active constituents. Analysis by GC and GC-MS of the essential oil and the enantiomeric excess found for alpha-pinene, beta-pinene and limonene allowed a better characterization of this species.
authors.affiliation: Laboratorio Dr. Gustavo A. Fester, Facultad de Ciencias Exactas y Naturales y Agrimensura, Universidad Nacional del Nordeste, Av. Libertad 5470, (3400), Corrientes, Argentina.
authors.forename: Ana M
authors.initials: AM
authors.lastname: Torres
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Camargo
authors.forename: Gabriela A L
authors.initials: GA
authors.lastname: Ricciardi
authors.forename: Armando I A
authors.initials: AI
authors.lastname: Ricciardi
authors.forename: Eduardo
authors.initials: E
authors.lastname: Dellacassa
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology; D001777:Blood Coagulation; D017837:Bothrops / Q000502:physiology*; D003435:Crotalid Venoms / Q000633:toxicity*; D006461:Hemolysis / Q000187:drug effects*; D019770:Lauraceae / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000925:Anticoagulants; D003435:Crotalid Venoms; D010936:Plant Extracts