title: Resistant trichomoniasis: successful treatment with combination therapy.
abstract: Metronidazole-resistant vaginal trichomoniasis remains a major therapeutic challenge. Two women with symptomatic metronidazole-resistant trichomoniasis had multiple unsuccessful courses of therapy with a broad array of medications. Both patients finally responded to combination treatment with intravaginal paromomycin cream and high-dose oral tinidazole.
authors.affiliation: Department of Obstetrics and Gynecology, Drexel University College of Medicine, Philadelphia, PA 19102, USA. pnyirjes@drexelmed.edu
authors.forename: Paul
authors.initials: P
authors.lastname: Nyirjesy
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Gilbert
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Mulcahy
mesh_terms: D000282:Administration, Intravaginal; D000284:Administration, Oral; D000328:Adult; D000981:Antiprotozoal Agents / Q000494:pharmacology / Q000627:therapeutic use; D000994:Antitrichomonal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D018432:Drug Resistance, Multiple; D005260:Female; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000494:pharmacology / Q000627:therapeutic use; D008875:Middle Aged; D010303:Paromomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D012747:Sexual Partners; D014011:Tinidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D014247:Trichomonas Vaginitis / Q000175:diagnosis / Q000188:drug therapy* / Q000469:parasitology; D014246:Trichomonas vaginalis / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000981:Antiprotozoal Agents; D000994:Antitrichomonal Agents; D014011:Tinidazole; D008795:Metronidazole; D010303:Paromomycin