title: Sex determination: switch and suppress.
abstract: The transcription factor Dmrt1 regulates male sexual development from flies and worms to humans. A newly discovered function is to suppress female differentiation in the testes. Thus, the gonadal fate decision is not final but has to be actively maintained throughout life.
authors.affiliation: University of Würzburg, Physiological Chemistry I, Biozentrum, Am Hubland, D-97074 Würzburg, Germany.
authors.forename: Amaury
authors.initials: A
authors.lastname: Herpin
authors.forename: Manfred
authors.initials: M
authors.lastname: Schartl
mesh_terms: D000818:Animals; D005260:Female; D018507:Gene Expression Regulation, Developmental; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D019849:Sex Determination Processes; D012733:Sex Differentiation; D013737:Testis / Q000166:cytology / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014714:Vertebrates / Q000235:genetics / Q000502:physiology*
chemical_list: C110547:DMRT1 protein; D014157:Transcription Factors