title: Cryptosporidiosis in children with acute lymphoblastic leukemia on maintenance chemotherapy.
abstract: Cryptosporidium is recognized as a cause of diarrhea associated with a high mortality in immunocompromised patients. We report on 2 pediatric cases of cryptosporidiosis during maintenance chemotherapy of acute lymphoblastic leukemia. The patients presented severe diarrheas, 1 of them was complicated by a cholangitis. Withdrawal of immunosuppressive treatments and adjunction of an adequate antiparasitic treatment cured the Cryptosporidium infection in both cases.
authors.affiliation: Service d'immuno-hématologie pédiatrique, Institut d'Hématologie et Oncologie Pédiatrique, Université Claude Bernard Lyon1, France. carine.halfon-domenech@chu-lyon.fr
authors.forename: Carine
authors.initials: C
authors.lastname: Domenech
authors.forename: Meja
authors.initials: M
authors.lastname: Rabodonirina
authors.forename: Nathalie
authors.initials: N
authors.lastname: Bleyzac
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Pagès
authors.forename: Yves
authors.initials: Y
authors.lastname: Bertrand
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D000977:Antiparasitic Agents / Q000627:therapeutic use; D002675:Child, Preschool; D003457:Cryptosporidiosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D060046:Maintenance Chemotherapy / Q000009:adverse effects; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D000977:Antiparasitic Agents