title: Memory complaints with and without memory impairment: the impact of leukoaraiosis on cognition.
abstract: White matter alterations, leukoaraiosis (LA) on structural MRI, are associated with cognitive deficits and increased risk of dementia. LA may also impact on subjective memory complaints in otherwise healthy older adults. Little is known about the interplay between LA memory complaints and cognition. We investigated cognitive phenotypes associated with LA in 42 non-demented older adults categorized as having subjective cognitive complaints with no objective cognitive impairment-the subjective cognitive impairment group (SCI; n = 12), amnesic mild cognitive impairment (aMCI; n = 20), or healthy controls (HC; n = 11). We measured LA severity on MRI with a 40-point visual rating scale. Controlling for age and Mini-Mental State Examination (MMSE) score, analyses revealed multiple between-group differences. Follow-up linear regression models investigating the underlying contributors to each clinic group's cognitive profile indicated that LA contributed to learning slope variance (after accounting for age and MMSE) but only for the SCI group. Although the SCI group showed a significantly steeper learning slope when compared to HC and aMCI, increasing LA severity negatively impacted this group's rate of learning. This, in conjunction with the significant contribution of age on SCI learning slope performance variance suggests that greater LA burden at a younger age may contribute to subtle changes in learning for individuals with subjective cognitive complaints.
authors.affiliation: Institute of Psychiatry, King's College London, London, United Kingdom. m.lamar@iop.kcl.ac.uk
authors.forename: Melissa
authors.initials: M
authors.lastname: Lamar
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Dannhauser
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Walker
authors.forename: Joanne E
authors.initials: JE
authors.lastname: Rodda
authors.forename: Darren J
authors.initials: DJ
authors.lastname: Cutinha
authors.forename: Sukhwinder S
authors.initials: SS
authors.lastname: Shergill
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D049292:Leukoaraiosis / Q000150:complications* / Q000523:psychology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000209:etiology / Q000523:psychology*; D008609:Mental Status Schedule; D008875:Middle Aged; D009483:Neuropsychological Tests; D010147:Pain Measurement; D011237:Predictive Value of Tests