title: Effects of proton pump inhibitors in patients with laryngopharyngeal reflux disease.
abstract: OBJECTIVE
  The effect of proton pump inhibitors (PPIs) on the health-related quality of life (HRQoL) of patients with laryngopharyngeal reflux disease (LPRD) is not well known. Our aim was to assess the HRQoL before and after administration of a PPI in patients with LPRD.
  
  
  METHODS
  A total of 27 LPRD patients (14 women, 13 men; mean age 54 years) were enrolled. We determined the HRQoL using three different inquiry systems: 1) Frequency Scale for the Symptoms of GERD (FSSG); 2) the 36 item short form of the Medical Outcome Study Questionnaire (SF-36); and 3) the Gastrointestinal Symptom Rating Scale (GSRS). The HRQoL was determined at baseline and after eight weeks of treatment with lansoprazole at a dose of 30mg once daily or rabeprazole at a dose of 10mg once daily.
  
  
  RESULTS
  After administration of the PPI, the FSSG, the SF-36 general health scale and mental health scale, GSRS reflux syndrome score, abdominal pain syndrome score and the indigestion syndrome score were significantly improved compared to baseline pretreatment scores (p<0.05).
  
  
  CONCLUSIONS
  PPI therapy would be useful for the treatment of LPRD.
authors.affiliation: Department of Internal Medicine, Iwate Medical University, Iwate, Japan. toschiba@iwate-med.ac.jp
authors.forename: Toshimi
authors.initials: T
authors.lastname: Chiba
authors.forename: Norihiko
authors.initials: N
authors.lastname: Kudara
authors.forename: Yukito
authors.initials: Y
authors.lastname: Abiko
authors.forename: Masaki
authors.initials: M
authors.lastname: Endo
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Suzuki
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Sugai
authors.forename: Ken
authors.initials: K
authors.lastname: Ishijima
authors.forename: Koji
authors.initials: K
authors.lastname: Fukuda
authors.forename: Kazuharu
authors.initials: K
authors.lastname: Yamazaki
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Sato
mesh_terms: D005260:Female; D006801:Humans; D057045:Laryngopharyngeal Reflux / Q000188:drug therapy*; D007828:Laryngoscopy; D008297:Male; D008875:Middle Aged; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D011788:Quality of Life; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D054328:Proton Pump Inhibitors