title: Effect of iron gel on dentin permeability.
abstract: This study evaluated in vitro the effect of an experimental gel containing iron on the reduction of hydraulic conductance of dentin. Thirty-six 1-mm-thick dentin discs obtained from extracted human third molars were divided into 3 groups of 10 specimens each. The groups corresponded to the following experimental materials: 1.23% acidulated phosphate fluoride gel, pH 4.1; 3% potassium oxalate gel, pH 4.1 (Oxa-Gel®); and iron sulfate gel (10 mmol/L FeSO4), pH 4.1. The gels were applied to dentin under the following conditions: after 37% phosphoric acid and before 6% citric acid. Data were analyzed statistically by ANOVA and Tukey's test at 5% significance level. There was no significant differences (p<0.05) among the groups in any of the conditions for hydraulic conductance reduction, except for smear layer presence. The active agents reduced dentin permeability, but they produced significantly lower (p<0.05) reduction in hydraulic conductance when compared to presence of smear layer. The effectiveness in reducing dentin permeability was not significantly different (p>0.05) among the gels. This study suggests that the iron gel promoted reduction in dentin permeability comparable to that of the other agents and thus may be considered a good clinical alternative for the treatment of dentin hypersensitivity.
authors.affiliation: Department of Pediatric Dentistry, Orthodontics and Community Health, Bauru Dental School, USP - University of São Paulo, Bauru, SP, Brazil. shcperes@usp.br
authors.forename: Sílvia Helena de Carvalho
authors.initials: SH
authors.lastname: Sales-Peres
authors.forename: João Victor Donazan
authors.initials: JV
authors.lastname: Reinato
authors.forename: André de Carvalho
authors.initials: Ade C
authors.lastname: Sales-Peres
authors.forename: Juliane Avansini
authors.initials: JA
authors.lastname: Marsicano
mesh_terms: D000149:Acidulated Phosphate Fluoride / Q000494:pharmacology; D019343:Citric Acid / Q000494:pharmacology; D003804:Dentin / Q000187:drug effects; D057133:Dentin Desensitizing Agents / Q000494:pharmacology*; D003806:Dentin Permeability / Q000187:drug effects*; D005296:Ferrous Compounds / Q000494:pharmacology*; D005782:Gels; D006801:Humans; D006874:Hydrostatic Pressure; D008422:Materials Testing; D010070:Oxalates / Q000494:pharmacology; D010756:Phosphoric Acids / Q000494:pharmacology; D016369:Smear Layer; D013997:Time Factors; D055815:Young Adult
chemical_list: D057133:Dentin Desensitizing Agents; D005296:Ferrous Compounds; D005782:Gels; D010070:Oxalates; D010756:Phosphoric Acids; D019343:Citric Acid; D000149:Acidulated Phosphate Fluoride; C020748:ferrous sulfate; C030242:phosphoric acid