title: [Anaphylactoid reactions associated with contaminated heparin from China].
abstract: In January 2008, fatal anaphylactoid reaction (AR) was found to be associated with oversulfated chondroitin sulphate (OSCS) contaminated heparin. Although attributed to bradykinin released during contact system activation by OSCS, no final evidence until now exists for a bradykinin release during incubation of contaminated heparin with human plasma. The first objective of our study was to measure and to characterize the kinetic profile of bradykinin release in human plasma incubated with OSCS and contaminated heparin. As these AR occurred mainly in the first minutes of the dialysis session, we examine the different factors likely to influence the kinin-forming capacity of OSCS: dilution of plasma, presence of an angiotensin converting enzyme inhibitor, capacity of the patient to metabolise kinins.
authors.affiliation: Faculté de Pharmacie, Université de Montréal, 2900, boulevard Édouard-Montpetit, H3T 1J4 Montréal, Canada.
authors.forename: N
authors.initials: N
authors.lastname: Montpas
authors.forename: A
authors.initials: A
authors.lastname: Désormeaux
authors.forename: D
authors.initials: D
authors.lastname: Keire
authors.forename: A
authors.initials: A
authors.lastname: Adam
mesh_terms: D000626:Aminopeptidases / Q000378:metabolism; D000707:Anaphylaxis / Q000139:chemically induced* / Q000378:metabolism; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000032:analysis; D000925:Anticoagulants / Q000009:adverse effects* / Q000737:chemistry / Q000627:therapeutic use; D001920:Bradykinin / Q000097:blood; D002681:China; D002809:Chondroitin Sulfates / Q000009:adverse effects* / Q000032:analysis; D003956:Dialysis; D004340:Drug Contamination; D006493:Heparin / Q000009:adverse effects* / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D007705:Kinins / Q000378:metabolism; D013431:Sulfates / Q000032:analysis
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000925:Anticoagulants; D007705:Kinins; D013431:Sulfates; D006493:Heparin; D002809:Chondroitin Sulfates; D000626:Aminopeptidases; C022750:X-Pro aminopeptidase; D001920:Bradykinin