title: Nuclear remodeling as a mechanism for genomic instability in cancer.
abstract: This chapter focuses on the three-dimensional organization of the nucleus in normal, early genomically unstable, and tumor cells. A cause-consequence relationship is discussed between nuclear alterations and the resulting genomic rearrangements. Examples are presented from studies on conditional Myc deregulation, experimental tumorigenesis in mouse plasmacytoma, nuclear remodeling in Hodgkin's lymphoma, and in adult glioblastoma. A model of nuclear remodeling is proposed for cancer progression in multiple myeloma. Current models of nuclear remodeling are described, including our model of altered nuclear architecture and the onset of genomic instability.
authors.affiliation: The University of Manitoba, Manitoba Institute of Cell Biology, Cancer Care Manitoba, The Genomic Centre for Cancer Research and Diagnosis, Winnipeg, Manitoba, Canada.
authors.forename: Macoura
authors.initials: M
authors.lastname: Gadji
authors.forename: Rhea
authors.initials: R
authors.lastname: Vallente
authors.forename: Ludger
authors.initials: L
authors.lastname: Klewes
authors.forename: Christiaan
authors.initials: C
authors.lastname: Righolt
authors.forename: Landon
authors.initials: L
authors.lastname: Wark
authors.forename: Narisorn
authors.initials: N
authors.lastname: Kongruttanachok
authors.forename: Hans
authors.initials: H
authors.lastname: Knecht
authors.forename: Sabine
authors.initials: S
authors.lastname: Mai
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000235:genetics*; D042822:Genomic Instability; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology*