title: Berkeleyones and related meroterpenes from a deep water acid mine waste fungus that inhibit the production of interleukin 1-β from induced inflammasomes.
abstract: The Berkeley Pit, an acid mine waste lake, is a source of extremophilic microorganisms that produce interesting bioactive compounds. We have previously reported the isolation of berkeleydione (1), berkeleytrione (2), the berkeleyacetals, and the berkeleyamides from the Pit Lake fungus Penicillium rubrum. In this paper we report the isolation and characterization of berkeleyones A-C (4, 5, and 7) as well as previously described preaustinoid A (3) and A1(6) from this same fungus. These compounds were evaluated as inhibitors of the signaling enzyme caspase-1 and as potential inhibitors of interleukin 1-β production by inflammasomes in induced THP-1 cell line assays.
authors.affiliation: Department of Biomedical and Pharmaceutical Sciences, The University of Montana, Missoula, Montana 59812, United States. donald.stierle@mso.umt.edu
authors.forename: Donald B
authors.initials: DB
authors.lastname: Stierle
authors.forename: Andrea A
authors.initials: AA
authors.lastname: Stierle
authors.forename: Brianna
authors.initials: B
authors.lastname: Patacini
authors.forename: Kyle
authors.initials: K
authors.lastname: McIntyre
authors.forename: Teri
authors.initials: T
authors.lastname: Girtsman
authors.forename: Erin
authors.initials: E
authors.lastname: Bolstad
mesh_terms: D061945:Caspase Inhibitors; D006801:Humans; D058847:Inflammasomes / Q000276:immunology*; D053583:Interleukin-1beta / Q000037:antagonists & inhibitors*; D060106:Lakes; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D009000:Monocytes / Q000187:drug effects; D010407:Penicillium / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D061945:Caspase Inhibitors; D058847:Inflammasomes; D053583:Interleukin-1beta; D018942:Macrolides; D013729:Terpenes; C493366:berkeleydione; C493367:berkeleytrione; C473688:preaustinoid A; C473687:preaustinoid B