title: Combination of thiazolidinedione and hydralazine suppresses proliferation and induces apoptosis by PPARγ up-expression in MDA-MB-231 cells.
abstract: No proven targeted therapy is currently available for the treatment of triple-negative breast cancer (TNBC). Ligand activation of peroxisome-activated receptor (PPAR)γ induces antitumor effects in cancer but not obviously in TNBC. In TNBC cells, combined treatment with thiazolidinedione and demethylation drugs Hydralazine up-regulated protein and mRNA levels of PPARγ. Besides, the combination of two drugs promote antiproliferative and apoptotic effects in TNBC cells and decrease the proliferation index in the tumor xenografts. Taken together, our results suggest that multidrug regimens including a combination of Thiazolidinedione and Hydralazine may provide a therapeutic advantage in TNBC.
authors.affiliation: Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, PR China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Jiang
authors.forename: Yeqing
authors.initials: Y
authors.lastname: Huang
authors.forename: Chun
authors.initials: C
authors.lastname: Cheng
authors.forename: Weiqi
authors.initials: W
authors.lastname: Lu
authors.forename: Yixin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Liu
authors.forename: Lin
authors.initials: L
authors.lastname: Zou
authors.forename: Qiwen
authors.initials: Q
authors.lastname: Ben
authors.forename: Aiguo
authors.initials: A
authors.lastname: Shen
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004359:Drug Therapy, Combination; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D006830:Hydralazine / Q000494:pharmacology / Q000627:therapeutic use; D008024:Ligands; D058990:Molecular Targeted Therapy; D047495:PPAR gamma / Q000819:agonists / Q000096:biosynthesis* / Q000235:genetics; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis; D045162:Thiazolidinediones / Q000494:pharmacology / Q000627:therapeutic use; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D006830:Hydralazine; D008024:Ligands; D047495:PPAR gamma; D018719:Erb-b2 Receptor Tyrosine Kinases; D045162:Thiazolidinediones; C508053:ERBB2 protein, human