title: Treatment of chronic hepatitis C in a patient with Fanconi anaemia.
abstract: Fanconi anaemia is a rare autosomal recessive disorder with progressive bone marrow failure and predisposition to malignancy. We report a case of a 26-year-old female patient with Fanconi anaemia and severe chronic active hepatitis C virus infection. Her past medical history included treatment with multiple blood transfusions and bone marrow transplantation at the age of 13. The decision to treat the infection was taken, and history of hematologic disease contributed to the introduction of therapy with leukocyte interferon-α n3 and ribavirin combined with a granulocyte - colony stimulating factor. The treatment was well tolerated and after 48 weeks a reduction of the viral load and alanine aminotransferase activity were achieved. No adverse effects on bone marrow functioning were noted.
authors.affiliation: Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Poland. pmagdar@gmail.com
authors.forename: M
authors.initials: M
authors.lastname: Rogalska-Płońska
authors.forename: A
authors.initials: A
authors.lastname: Parfieniuk-Kowerda
authors.forename: T W
authors.initials: TW
authors.lastname: Lapiński
authors.forename: R
authors.initials: R
authors.lastname: Flisiak
mesh_terms: D000328:Adult; D005199:Fanconi Anemia / Q000150:complications* / Q000628:therapy*; D005260:Female; D005838:Genotype; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000628:therapy*; D006801:Humans; D016898:Interferon-alpha / Q000008:administration & dosage; D010641:Phenotype; D012254:Ribavirin / Q000008:administration & dosage; D012306:Risk; D013997:Time Factors; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D016898:Interferon-alpha; D016179:Granulocyte Colony-Stimulating Factor; C554126:Interferon Alfa-n3; D012254:Ribavirin