title: [The extracellular role of high mobility group box-1 protein in regulation of immune response].
abstract: High mobility group box-1 protein (HMGB1), a highly conserved nuclear DNA-binding protein, is involved in maintenance of nucleosome structure and regulation of gene replication, transcription and translation. Recently, there is accumulating evidence that HMGB1 can be passively or actively released from the nucleus to the extracellular milieu and act as a late proinflammatory cytokine that mediates development of inflammatory diseases, including sepsis. In addition, HMGB1 can also act as an "alarm signal" regulating immune response of host. In this article, we summarized the structure, secretion and receptor signaling pathways of HMGB1. Furthermore, the role and potential mechanism underlying HMGB1 in regulation of immune function were also discussed.
authors.affiliation: Emergency Center, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China.
authors.forename: Lu-Ming
authors.initials: LM
authors.lastname: Tang
authors.forename: Zhong-Qiu
authors.initials: ZQ
authors.lastname: Lu
authors.forename: Yong-Ming
authors.initials: YM
authors.lastname: Yao
mesh_terms: D000818:Animals; D005110:Extracellular Space / Q000378:metabolism; D024243:HMGB1 Protein / Q000502:physiology*; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D007249:Inflammation / Q000503:physiopathology
chemical_list: D024243:HMGB1 Protein