title: New drugs for prostate cancer.
abstract: What's known on the subject? and What does the study add? Recent studies have demonstrated the efficacy of various new treatments. These have been in diverse areas of therapeutics research, including immunology and targeted biological therapy, as well as in new ways of approaching hormone refractory disease. The present paper seeks to review all of the key advances that have been reported in late-stage clinical studies and place them into the context of managing patients with advanced prostate cancer.
  
  
  OBJECTIVE
  • To describe some of the most exciting late stage clinical developments in the field of new therapies for advanced prostate cancer.
  
  
  METHODS
  • Pubmed was searched for articles pertaining to prostate cancer therapeutics clinical trials in the last 3 years.
  
  
  RESULTS
  • Key positive trials in the areas of androgen resistance, tumour immunology, molecularly targeted agents and cytotoxics were reviewed and discussed in the context of metastatic prostate cancer.
  
  
  CONCLUSIONS
  • Treatments emerging from these areas of scientific endeavour are progressing into clinical trials and are both good cause for hope in patients, and excellent examples of mechanism based drug discovery.
authors.affiliation: Department of Surgery and Cancer, Imperial College London, London, UK.
authors.forename: Constantine
authors.initials: C
authors.lastname: Alifrangis
authors.forename: Ciara
authors.initials: C
authors.lastname: O'Hanlon-Brown
authors.forename: Mark
authors.initials: M
authors.lastname: Tuthill
authors.forename: Jonathan
authors.initials: J
authors.lastname: Waxman
mesh_terms: D000726:Androgen Antagonists / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000517:prevention & control / Q000556:secondary; D019496:Cancer Vaccines / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D055808:Drug Discovery / Q000379:methods*; D019008:Drug Resistance, Neoplasm; D006801:Humans; D008297:Male; D058990:Molecular Targeted Therapy; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy*; D011471:Prostatic Neoplasms / Q000188:drug therapy*
chemical_list: D000726:Androgen Antagonists; D000970:Antineoplastic Agents; D019496:Cancer Vaccines