title: Chromosome 9 ALS and FTD locus is probably derived from a single founder.
abstract: We and others have recently reported an association between amyotrophic lateral sclerosis (ALS) and single nucleotide polymorphisms on chromosome 9p21 in several populations. Here we show that the associated haplotype is the same in all populations and that several families previously shown to have genetic linkage to this region also share this haplotype. The most parsimonious explanation of these data are that there is a single founder for this form of disease.
authors.affiliation: Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, UK.
authors.forename: Kin
authors.initials: K
authors.lastname: Mok
authors.forename: Bryan J
authors.initials: BJ
authors.lastname: Traynor
authors.forename: Jennifer
authors.initials: J
authors.lastname: Schymick
authors.forename: Pentti J
authors.initials: PJ
authors.lastname: Tienari
authors.forename: Hannu
authors.initials: H
authors.lastname: Laaksovirta
authors.forename: Terhi
authors.initials: T
authors.lastname: Peuralinna
authors.forename: Liisa
authors.initials: L
authors.lastname: Myllykangas
authors.forename: Adriano
authors.initials: A
authors.lastname: Chiò
authors.forename: Aleksey
authors.initials: A
authors.lastname: Shatunov
authors.forename: Bradley F
authors.initials: BF
authors.lastname: Boeve
authors.forename: Adam L
authors.initials: AL
authors.lastname: Boxer
authors.forename: Mariely
authors.initials: M
authors.lastname: DeJesus-Hernandez
authors.forename: Ian R
authors.initials: IR
authors.lastname: Mackenzie
authors.forename: Adrian
authors.initials: A
authors.lastname: Waite
authors.forename: Nigel
authors.initials: N
authors.lastname: Williams
authors.forename: Huw R
authors.initials: HR
authors.lastname: Morris
authors.forename: Javier
authors.initials: J
authors.lastname: Simón-Sánchez
authors.forename: John C
authors.initials: JC
authors.lastname: van Swieten
authors.forename: Peter
authors.initials: P
authors.lastname: Heutink
authors.forename: Gabriella
authors.initials: G
authors.lastname: Restagno
authors.forename: Gabriele
authors.initials: G
authors.lastname: Mora
authors.forename: Karen E
authors.initials: KE
authors.lastname: Morrison
authors.forename: Pamela J
authors.initials: PJ
authors.lastname: Shaw
authors.forename: Pamela Sara
authors.initials: PS
authors.lastname: Rollinson
authors.forename: Ammar
authors.initials: A
authors.lastname: Al-Chalabi
authors.forename: Rosa
authors.initials: R
authors.lastname: Rademakers
authors.forename: Stuart
authors.initials: S
authors.lastname: Pickering-Brown
authors.forename: Richard W
authors.initials: RW
authors.lastname: Orrell
authors.forename: Michael A
authors.initials: MA
authors.lastname: Nalls
authors.forename: John
authors.initials: J
authors.lastname: Hardy
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D005387:Finland; D057180:Frontotemporal Dementia / Q000235:genetics*; D008040:Genetic Linkage; D055106:Genome-Wide Association Study; D006239:Haplotypes; D006801:Humans; D020641:Polymorphism, Single Nucleotide