title: [Disulfiram and addiction: reminders and new perspectives of use].
abstract: Disulfiram is a relatively old molecule, which today remains marginal in the treatment of alcoholics diseases. Using this type of treatment is the subject of ethical debate. The prescription of this therapeutic requires clinical and biological rigorous evaluations before treatment. Its main action in treatment of alcoholism is related to the restraint of acetaldehyde dehydrogenase action causing the antabuse reaction. Prescription of disulfiram, supported by specialized programs of compartmental integrated care, brings significant benefit for alcoholic patients. Recently, following the discovery of its action on dopamine metabolism, disulfiram has been a renewed interest in the treatment of addictions to cocaine and pathological gambling. Although current data are insufficient to generalize its use in routine practice, they constitute a line of research interest for the future.
authors.affiliation: Service de Psychiatrie de l'Adulte B, CHU de Clermont-Ferrand, Clermont-Ferrand, France. tcharpeaud@chu-clermonferrand.fr
authors.forename: Thomas
authors.initials: T
authors.lastname: Charpeaud
authors.forename: Julie
authors.initials: J
authors.lastname: Geneste
authors.forename: Jeannot
authors.initials: J
authors.lastname: Schmidt
authors.forename: Pierre-Michel
authors.initials: PM
authors.lastname: Llorca
authors.forename: Georges
authors.initials: G
authors.lastname: Brousse
mesh_terms: D000427:Alcohol Deterrents / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D000437:Alcoholism / Q000188:drug therapy*; D002492:Central Nervous System Depressants / Q000493:pharmacokinetics; D004221:Disulfiram / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D004298:Dopamine / Q000378:metabolism; D004343:Drug Implants; D000431:Ethanol / Q000493:pharmacokinetics; D005715:Gambling; D006801:Humans; D019966:Substance-Related Disorders / Q000188:drug therapy
chemical_list: D000427:Alcohol Deterrents; D002492:Central Nervous System Depressants; D004343:Drug Implants; D000431:Ethanol; D004221:Disulfiram; D004298:Dopamine