title: From conventional fluid cytology to unusual histological diagnosis: report of four cases.
abstract: Malignant small round cell tumors represent a diagnostic challenge for cytologists and pathologists. This case series describes four cases of unusual metastasis of small round cell tumors subtypes into body cavities generating effusions in which fluid cytological examination suggested the neuroendocrine origin of the tumors. Tumor diagnosis (Ewing sarcoma/primitive neuroectodermal tumor and desmoplastic small round cell tumors) were unknown at the cytological evaluation. We can highlight the importance of the accurate analyses of body fluids, both for early diagnosis of metastatic disease, and for the diagnosis of primary tumor when serous effusion is the first manifestation of the neoplasia.
authors.affiliation: Cytology Section, Clinical Laboratory, Pathology Department, Hospital das Clínicas, University of São Paulo Medical School, São Paulo-SP, Brazil.
authors.forename: Marcelo José Andrade
authors.initials: MJ
authors.lastname: Oliveira
authors.forename: Laís Pinto
authors.initials: LP
authors.lastname: de Almeida
authors.forename: Annelise Correa
authors.initials: AC
authors.lastname: Wengerkievicz
authors.forename: Sheila Aparecida Coelho
authors.initials: SA
authors.lastname: Siqueira
authors.forename: Leila
authors.initials: L
authors.lastname: Antonangelo
mesh_terms: D000293:Adolescent; D000328:Adult; D001202:Ascitic Fluid / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis*; D002454:Cell Differentiation; D048429:Cell Size; D058405:Desmoplastic Small Round Cell Tumor / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis / Q000473:pathology; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000175:diagnosis*; D009697:Nucleolus Organizer Region / Q000473:pathology; D010537:Peritoneum / Q000473:pathology; D010994:Pleura / Q000473:pathology; D012512:Sarcoma, Ewing / Q000175:diagnosis*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor