title: Therapeutic effect of paroxetine on stress-induced gastric lesions in mice.
abstract: Compared to the well-known anti-ulcerogenic properties of tricyclic antidepressants, the impact of selective serotonin reuptake inhibitors (SSRIs) on gastric mucosa is less clear. Human clinical trials have shown that SSRIs and non-steroidal anti-inflammatory drugs (NSAIDs) act synergistically and promote stomach ulcer formation and upper gastrointestinal tract bleeding. Acute SSRI treatment confers an additional risk for the formation of NSAID-induced gastric ulcers through increase in gastric acid secretion. Stress, which is often experienced by depressed patients, also deteriorates the gastric environment. Thus the potential for exacerbating stress-induced gastric lesions must be considered before prescribing SSRIs. Therefore, we evaluated the effects of paroxetine by using a water-immersion stress-induced stomach ulcer model of mice, by examining single vs. repeated paroxetine treatments for 8 and 22 days before stress induction. Repeated administration of paroxetine significantly decreased the area of stress-induced stomach lesions. Although stress significantly increased the serum corticosterone concentrations, the levels were not affected by the 8-day paroxetine treatment. We confirmed the anxiolytic and antidepressive effects of 8-day paroxetine treatment at 1 and 5 days after stress induction by using the elevated plus-maze and tail-suspension tests. We concluded that repeated paroxetine treatment significantly attenuates the stress-induced ulcerogenic process in the stomach.
authors.affiliation: Department of Psychiatry, National Defense Medical College, Namiki 3-2, Tokorozawa, Saitama 359-8513, Japan.
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Takahashi
authors.forename: Go
authors.initials: G
authors.lastname: Suzuki
authors.forename: Masashi
authors.initials: M
authors.lastname: Nibuya
authors.forename: Teppei
authors.initials: T
authors.lastname: Tanaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nozawa
authors.forename: Ben
authors.initials: B
authors.lastname: Hatano
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Kunio
authors.initials: K
authors.lastname: Shimizu
authors.forename: Taisuke
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Shoichi
authors.initials: S
authors.lastname: Tachibana
authors.forename: Soichiro
authors.initials: S
authors.lastname: Nomura
mesh_terms: D000818:Animals; D003345:Corticosterone / Q000097:blood; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D017374:Paroxetine / Q000627:therapeutic use*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D013276:Stomach Ulcer / Q000097:blood* / Q000188:drug therapy* / Q000473:pathology; D013315:Stress, Psychological / Q000097:blood*; D016896:Treatment Outcome
chemical_list: D003345:Corticosterone; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors