title: Physico-chemical characterization of nano-emulsions in cosmetic matrix enriched on omega-3.
abstract: BACKGROUND
  Nano-emulsions, as non-equilibrium systems, present characteristics and properties which depend not only on composition but also on their method of preparation. To obtain better penetration, nanocosmeceuticals use nano-sized systems for the delivery of active ingredients to targeted cells. In this work, nano-emulsions composed of miglyol, rapeseed oil and salmon oil were developed as a cosmetic matrix. Measurements of different physico-chemical properties of nano-emulsions were taken according to size, electrophoretic mobility, conductivity, viscosity, turbidity, cristallization and melting point. The RHLB was calculated for each formulation in order to achieve maximum stability.
  
  
  RESULTS
  Both tween 80 and soya lecithin were found to stabilize formulations. The results showed that rapeseed oil and miglyol are the predominant parameters for determining the expression of results concerning the characterization of emulsion. Based on the mixture design, we achieved the optimal point using the following formulation: 56.5% rapessed oil, 35.5% miglyol, and 8% salmon oil. We considered this formulation to be the best as a nanocosmeceutical product due to the small size, good turbidity, and average HLB.
  
  
  CONCLUSIONS
  This study demonstrates the influence of formulation on the physico-chemical properties of each nano-emulsion obtained by the mixture design.
authors.affiliation: Laboratoire d'Ingénierie des Biomolécules (LIBio), Nancy-Université, 2 avenue de la Forêt de Haye, 54500 Vandoeuvre-lès-Nancy, France.
authors.forename: Tin-Hinan
authors.initials: TH
authors.lastname: Kabri
authors.forename: Elmira
authors.initials: E
authors.lastname: Arab-Tehrany
authors.forename: Nabila
authors.initials: N
authors.lastname: Belhaj
authors.forename: Michel
authors.initials: M
authors.lastname: Linder
mesh_terms: D055598:Chemical Phenomena; D003358:Cosmetics / Q000737:chemistry; D003460:Crystallization; D004553:Electric Conductivity; D004655:Emulsions / Q000737:chemistry*; D005229:Fatty Acids, Monounsaturated; D015525:Fatty Acids, Omega-3 / Q000737:chemistry*; D005395:Fish Oils / Q000737:chemistry; D054709:Lecithins / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D010316:Particle Size; D010938:Plant Oils / Q000737:chemistry; D011136:Polysorbates / Q000737:chemistry; D000074262:Rapeseed Oil; D013024:Soybean Oil / Q000737:chemistry; D014783:Viscosity
chemical_list: D003358:Cosmetics; D004655:Emulsions; D005229:Fatty Acids, Monounsaturated; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D054709:Lecithins; D010938:Plant Oils; D011136:Polysorbates; D000074262:Rapeseed Oil; C030341:salmon oil; D013024:Soybean Oil