title: Sixty percent 10-year survival of patients with chondrosarcoma after local recurrence.
abstract: BACKGROUND
  Chondrosarcoma is treated primarily by surgery. The prognosis of patients after local recurrence is not well defined. Both the survival of patients and the risk of further local relapse after surgical treatment of local recurrence have yet to be established.
  
  
  OBJECTIVE
  We determined survival after local recurrence of chondrosarcoma, the rate of further local recurrences, and prognostic factors predicting survival.
  
  
  METHODS
  We retrospectively reviewed 52 patients treated for locally recurrent conventional chondrosarcoma between 1975 and 2008. All patients had nonmetastatic disease at the time of diagnosis. There were 36 males and 16 females with a median age of 39 years (range, 16-79 years). We analyzed variables affecting overall and disease-free survival. The minimum followup was 12 months unless patients died of disease before 12 months (median, 68 months; range, 4-387 months).
  
  
  RESULTS
  Thirty patients developed their first local recurrence in axial locations, while 22 developed recurrence in the appendicular skeleton. After local recurrence, overall survival was 74% at 5 years and 60% at 10 years. The mean number of local recurrences was three (range, 1-14). Surgical margin correlated with further local recurrence but not survival. Tumor grade, axial location, metastases, and age independently predicted survival.
  
  
  CONCLUSIONS
  Prolonged survival of patients after local recurrence of conventional chondrosarcoma is possible, albeit with further recurrences in many patients.
  
  
  METHODS
  Level IV, prognostic study. See Guidelines for Authors for a complete description of levels of evidence.
authors.affiliation: Department of Orthopaedic Oncology, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA. plin@mdanderson.org
authors.forename: Patrick P
authors.initials: PP
authors.lastname: Lin
authors.forename: Mohammed D
authors.initials: MD
authors.lastname: Alfawareh
authors.forename: Akihiko
authors.initials: A
authors.lastname: Takeuchi
authors.forename: Bryan S
authors.initials: BS
authors.lastname: Moon
authors.forename: Valerae O
authors.initials: VO
authors.lastname: Lewis
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000401:mortality* / Q000473:pathology; D002813:Chondrosarcoma / Q000401:mortality / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality*; D012189:Retrospective Studies; D055815:Young Adult