title: Expression and clinical significance of L-plastin in colorectal carcinoma.
abstract: BACKGROUND
  L: -plastin, an actin-binding protein, is upregulated in many tumours, including colorectal carcinoma. This study evaluated the expression of L: -plastin in plasma and colorectal tumour tissue and analysed the correlation between clinicopathological staging and prognosis.
  
  
  METHODS
  Enzyme-linked immunosorbent assay was used to detect L: -plastin in the plasma of 120 colorectal carcinoma patients and 40 control subjects. Immunohistochemistry analyses were also used.
  
  
  RESULTS
  The rate of positive L: -plastin expression was significantly higher in colorectal carcinoma patients than in control subjects, and was significantly higher in tumour tissues than in the tissues surrounding the tumour. L: -Plastin expression also is correlated with tumour grade and size, and lymph node metastasis. However, there was no correlation with the extent of tumour invasion or distant metastasis.
  
  
  CONCLUSIONS
  L: -Plastin may be a useful marker for screening colorectal carcinoma and determining the prognosis of patients with colorectal carcinoma, and for genetic therapy and targeted therapy of colorectal carcinoma.
authors.affiliation: Department of General Surgery, Ruijin Hospital, Shanghai Jiaotong University, No.197 Ruijin Er Road, Shanghai, 200025, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Ren
authors.initials: R
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D019540:Area Under Curve; D014408:Biomarkers, Tumor / Q000097:blood / Q000378:metabolism*; D002277:Carcinoma / Q000097:blood / Q000378:metabolism* / Q000473:pathology*; D015179:Colorectal Neoplasms / Q000097:blood / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood / Q000378:metabolism*; D008840:Microfilament Proteins / Q000097:blood / Q000378:metabolism*; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012372:ROC Curve
chemical_list: D014408:Biomarkers, Tumor; D008562:Membrane Glycoproteins; D008840:Microfilament Proteins; C026742:plastin