title: Ganodone, a bioactive benzofuran from the fruiting bodies of Ganoderma tsugae.
abstract: Extracts of Ganoderma tsugae, also known as the Hemlock varnish shelf mushroom, and related Reishi mushrooms are well documented in traditional Chinese medicine. Several Ganoderma sp. are currently cultivated for use in coffee, teas, and dietary supplements. We now report on the isolation and characterization of an unprecedented benzofuran, ganodone (1), from the fruiting bodies of mature growth G. tsugae. This discovery provides a key next step in evaluating the active components in their associated herbal supplements.
authors.affiliation: Xenobe Research Institute, P.O. Box 3052, San Diego, California 92163-1052, United States. i@xenobe.org
authors.forename: James J
authors.initials: JJ
authors.lastname: La Clair
authors.forename: Arnold L
authors.initials: AL
authors.lastname: Rheingold
authors.forename: Michael D
authors.initials: MD
authors.lastname: Burkart
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D048690:Fruiting Bodies, Fungal / Q000737:chemistry*; D032902:Ganoderma / Q000737:chemistry*; D045325:HCT116 Cells; D006367:HeLa Cells; D006801:Humans; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000970:Antineoplastic Agents; D001572:Benzofurans; C568647:ganodone