title: [Rotavirus vaccine].
abstract: Rotavirus is the single main cause of severe acute gastroenteritis in children less than 5 years of age, resulting in over 527,000 deaths worldwide annually. The majority of rotavirus-related deaths are seen in less-developed countries; in developed countries, rotavirus is an infrequent cause of death but a commom cause of hospitalizations. Rotavirus gastroenteritis was also estimated to result in approximately 790,000 doctor visits every year leading to medical intervention among children aged 0-5 years in Japan. At present, the treatment of rotavirus gastroenteritis in Japan is limited to symptomatic measures and no antiviral therapy is available. A phase III, randomized, double-blind study evaluated the efficacy, reactogenicity, safety and immunogenicity of a human rotavirus vaccine in Japanese infants. Rotavirus vaccine was efficacious, well-tolerated and immunogenic in Japanese infants and introduction of vaccination would help in reducing the disease burden.
authors.affiliation: Department of Pediatrics, Osaka Rosai Hospital.
authors.forename: Naohisa
authors.initials: N
authors.lastname: Kawamura
mesh_terms: D002675:Child, Preschool; D005767:Gastrointestinal Diseases / Q000517:prevention & control; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D012400:Rotavirus Infections / Q000517:prevention & control; D022243:Rotavirus Vaccines
chemical_list: D022243:Rotavirus Vaccines