title: [Postvaccination immunity against influenza in patients with chronic broncho-pulmonary pathology].
abstract: OBJECTIVE
  Evaluation of postvaccination immunity against influenza in patients with bronchopulmonary pathology.
  
  
  METHODS
  22 patients with broncho-pulmonary pathology vaccinated against influenza with Grippol plus preparation participated in the study. Rates of influenza and acute respiratory illnesses (ARI), rates and duration of exacerbations of the underlying disease were tracked based on medical documents. Hemagglutination inhibition reaction in paired sera before and 6 and 12 months after the vaccination was used to evaluate vaccine immunogenicity.
  
  
  RESULTS
  None of the patients had influenza diagnosis for one year. A reduction of ARI rate of 37% was detected. Rate of exacerbation of the underlying disease decreased by 1.9 times, duration of exacerbations--by 2 times. Data on immunogenicity against A/H1N1/ Brisbane/59/07, A/H3N2/Uruguay/716/2007, B/ Florida/4/2006 are presented. Immunogenicity against B/Brisbane/60/2008 strain not contained in the vaccine was insufficient to induce adequate protection. Statistically significant differences were not detected during comparison of immunogenicity in patients with broncho-pulmonary pathology and healthy people.
  
  
  CONCLUSIONS
  Grippol plus vaccine in patients with respiratory tract diseases is immunogenic and renders clinical effect by reducing influenza morbidity and rate of exacerbation of the underlying disease.
authors.forename: A V
authors.initials: AV
authors.lastname: Chebykina
authors.forename: M P
authors.initials: MP
authors.lastname: Kostinov
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D001982:Bronchial Diseases / Q000150:complications*; D002908:Chronic Disease; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007109:Immunity; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D053122:Influenza A Virus, H3N2 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology*; D007251:Influenza, Human / Q000150:complications / Q000276:immunology / Q000517:prevention & control*; D008171:Lung Diseases / Q000150:complications*; D008297:Male; D008875:Middle Aged; D014611:Vaccination
chemical_list: D000914:Antibodies, Viral; C408342:Grippol; D007252:Influenza Vaccines