title: Biological dosimetry after radiosynoviorthesis with rhenium-186 sulphide and erbium-169 citrate.
abstract: Radiosynoviorthesis (RSO) with the nuclides rhenium-186 sulphide (186Re) and erbium-169 citrate (169Er) is an established concept for the treatment of persistent synovitis of medium and small sized joints. THE AIM of the present studies was to investigate the biological radiation effect based on analysing chromosome aberrations.
  
  
  METHODS
  Immediately before and 17 to 19 days (186Re) or 45 to 50 (169Er) days after RSO with 186Re or 169Er colloid and subsequent immobilisation of the treated joint, blood samples of a total of 23 patients were collected. The yield of dicentric chromosomes in lymphocytes was determined exclusively in metaphases of the first cell cycle in vitro. In addition, for 186Re the activity leakage was measured three days after RSO by whole-body scintigraphy.
  
  
  RESULTS
  No statistically significant increase in the number of dicentric chromosomes (40 and 88 before and 59 and 105 after treatment with 186Re and 169Er, respectively) in a total of 47017 cells analysed from 46 blood samples could be found as a result of RSO. For 186Re an activity leakage of 3.9%±7% with a maximum of 23.4% corresponding to an effective dose of 2.8±4.5 mSv , respectively 13.8 mSv, was determined. Also in the case of the maximum leakage no significant increase of dicentric chromosomes were detected.
  
  
  CONCLUSIONS
  No significant biological radiation effect can be detected after RSO with 186Re and 169Er, also in cases of high leakage. Therefore, RSO can be classified as a save therapeutic procedure without a relevant radiation risk.
authors.affiliation: Nuclear medicine practice, Paul-Zipp-Strasse 171-173, 35398 Giessen, Germany. rigobert.klett@radiol.med.uni-giessen.de
authors.forename: R
authors.initials: R
authors.lastname: Klett
authors.forename: A
authors.initials: A
authors.lastname: Schnurbus-Duhs
authors.forename: G
authors.initials: G
authors.lastname: Mödder
authors.forename: E
authors.initials: E
authors.lastname: Schmid
authors.forename: M
authors.initials: M
authors.lastname: Voth
mesh_terms: D000328:Adult; D000368:Aged; D001681:Biological Assay / Q000379:methods; D002712:Chlorides / Q000032:analysis / Q000627:therapeutic use*; D004871:Erbium / Q000032:analysis / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D009928:Organ Specificity; D011868:Radioisotopes / Q000032:analysis / Q000627:therapeutic use*; D011874:Radiometry; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D012211:Rhenium / Q000032:analysis / Q000627:therapeutic use*; D013440:Sulfides; D013585:Synovitis / Q000532:radiotherapy*
chemical_list: D002712:Chlorides; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D013440:Sulfides; C400124:rhenium sulfide; D012211:Rhenium; D004871:Erbium