title: Phosphoinositides and photoreceptors.
abstract: The importance of phosphoinositides (phosphorylated phosphatidyl inositol derivatives, PIs) for normal cellular function cannot be overstated. Although they represent a small fraction of the total phospholipid within the cell, they are essential regulators of many cellular functions. They direct membrane trafficking by functioning as recruitment factors for vesicular trafficking components, they can modulate ion channel activity through direct binding within cellular membranes, and their hydrolysis generates second messenger signaling molecules. Despite an explosion of information regarding the importance of these lipids in cellular biology, their precise roles in vertebrate retinal photoreceptors has not been established. This review summarizes the literature on potential roles for different phosphoinositides and their regulators in vertebrate rods and cones. A brief description of the importance of PI signaling in other photosensitive cells is also presented. The highly specialized functions of the vertebrate photoreceptor, combined with the established importance of phosphoinositides, promise significant future discoveries in this field.
authors.affiliation: Department of Biochemistry, University of Washington, Seattle, WA 98195, USA. sbrocker@uw.edu
authors.forename: Susan E
authors.initials: SE
authors.lastname: Brockerhoff
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000737:chemistry; D008027:Light; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism*; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics / Q000378:metabolism; D010786:Photoreceptor Cells / Q000166:cytology / Q000502:physiology*; D021381:Protein Transport; D015398:Signal Transduction / Q000502:physiology; D013569:Synapses / Q000378:metabolism; D014785:Vision, Ocular / Q000502:physiology
chemical_list: D009419:Nerve Tissue Proteins; D010716:Phosphatidylinositols; D019869:Phosphatidylinositol 3-Kinases; C097702:synaptojanin; D010744:Phosphoric Monoester Hydrolases