title: [Bullae-associated lung cancer: two case reports and literature review].
abstract: OBJECTIVE
  Most of lung cancers present with a parenchymal mass. Lung cancers that present as bullae under imaging are unusual. The aim of the current article is to raise awareness regarding bullae-associated lung cancer through two case reports and their corresponding review of literature.
  
  
  METHODS
  The clinical, auxiliary examination data, and the diagnosis of two patients with bullae-associated lung cancer are presented and the relevant literature are reviewed.
  
  
  RESULTS
  Most cases of bullae-associated lung cancer are male heavy smokers. Considering the incidence of pulmonary carcinoma associated with bullous disease is high, radiographic findings would aid in the early detection of a malignant lesion.
  
  
  CONCLUSIONS
  Bullous lung disease is a risk factor for lung cancer, and male, middle-age patients with bullae who smoke should be followed up by chest computed tomography and further examination. If the bullae may be diagnosed as lung cancer, an exploratory thoracotomy should be performed as early as possible.
authors.affiliation: Department of Respiratory Medicine, Affiliated Hospital of Medical College of Ningbo University, Ningbo 315020, China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Yu
authors.forename: Min
authors.initials: M
authors.lastname: Shi
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
authors.forename: Liang
authors.initials: L
authors.lastname: Chen
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Zhao
authors.forename: Zaichun
authors.initials: Z
authors.lastname: Deng
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D001768:Blister / Q000150:complications*; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy; D008297:Male; D014057:Tomography, X-Ray Computed