title: Hippocampal stimulation in the treatment of epilepsy.
abstract: Neuromodulation is one of the fastest growing fields in neurosurgery, as reflected by the growing interest in the use of electrical brain stimulation (EBS) to treat drug-resistant epilepsy, pain, and movement disorders. Hippocampal stimulation should be regarded as an experimental therapy for epilepsy, and patients considered for this intervention should do so in the context of a well-designed randomized controlled trial. Only well-conducted, blinded, randomized trials, followed by long-term systematic observation will yield a clear picture of the effect of this promising therapy, and will help guide its future use. This article provides a critical review of the best available evidence on hippocampal stimulation for epilepsy.
authors.affiliation: Division of Neurology, Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
authors.forename: Jose F
authors.initials: JF
authors.lastname: Tellez-Zenteno
authors.forename: Samuel
authors.initials: S
authors.lastname: Wiebe
mesh_terms: D038481:Anterior Temporal Lobectomy / Q000009:adverse effects; D002986:Clinical Trials as Topic; D046690:Deep Brain Stimulation / Q000295:instrumentation / Q000379:methods*; D004567:Electrodes, Implanted / Q000592:standards; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology* / Q000628:therapy*; D006624:Hippocampus / Q000503:physiopathology* / Q000601:surgery*; D006801:Humans