title: Effects of similar intakes of marine n-3 fatty acids from enriched food products and fish oil on cardiovascular risk markers in healthy human subjects.
abstract: There is convincing evidence that consumption of fish and fish oil rich in long-chain (LC) n-3 PUFA (n-3 LCPUFA), EPA (20 : 5n-3) and DHA (22 : 6n-3) reduce the risk of CHD. The aim of the present study was to investigate whether n-3 LCPUFA-enriched food products provide similar beneficial effects as fish oil with regard to incorporation into plasma lipids and effects on cardiovascular risk markers. A parallel 7-week intervention trial was performed where 159 healthy men and women were randomised to consume either 34 g fish pâté (n 44), 500 ml fruit juice (n 38) or three capsules of concentrated fish oil (n 40), all contributing to a daily intake of approximately 1 g EPA and DHA. A fourth group did not receive any supplementation or food product and served as controls (n 37). Plasma fatty acid composition, serum lipids, and markers of inflammation and oxidative stress were measured. Compared with the control group, plasma n-3 LCPUFA and EPA:arachidonic acid ratio increased equally in all intervention groups. However, no significant changes in blood lipids and markers of inflammation and oxidative stress were observed. In conclusion, enriched fish pâté and fruit juice represent suitable delivery systems for n-3 LCPUFA. However, although the dose given is known to reduce the risk of CVD, no significant changes were observed on cardiovascular risk markers in this healthy population.
authors.affiliation: Nofima AS, Norwegian Institute of Food, Fisheries and Aquaculture Research, Osloveien 1, 1430 Ås, Norway.
authors.forename: Bente
authors.initials: B
authors.lastname: Kirkhus
authors.affiliation: Mills DA, Oslo, Norway.
authors.forename: Amandine
authors.initials: A
authors.lastname: Lamglait
authors.affiliation: Faculty of Biosciences, Fishery and Economics, University of Tromsø, Tromsø, Norway.
authors.forename: Karl-Erik
authors.initials: KE
authors.lastname: Eilertsen
authors.affiliation: Mills DA, Oslo, Norway.
authors.forename: Eva
authors.initials: E
authors.lastname: Falch
authors.affiliation: Link Medical Research AS, Oslo, Norway.
authors.forename: Trond
authors.initials: T
authors.lastname: Haider
authors.affiliation: Aker BioMarine Antarctic AS, Oslo, Norway.
authors.forename: Hogne
authors.initials: H
authors.lastname: Vik
authors.affiliation: Aker BioMarine Antarctic AS, Oslo, Norway.
authors.forename: Nils
authors.initials: N
authors.lastname: Hoem
authors.affiliation: Department of Medical Biochemistry, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
authors.forename: Tor-Arne
authors.initials: TA
authors.lastname: Hagve
authors.affiliation: Department of Public Health and Caring Sciences, Uppsala University, Uppsala SE-755 85, Sweden.
authors.forename: Samar
authors.initials: S
authors.lastname: Basu
authors.affiliation: Denomega Nutritional Oils, Sarpsborg, Norway.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Olsen
authors.affiliation: Department of Cardiology, Oslo University Hospital, Ullevål, Oslo, Norway.
authors.forename: Ingebjørg
authors.initials: I
authors.lastname: Seljeflot
authors.affiliation: Skånemejerier, Malmø, Sweden.
authors.forename: Lena
authors.initials: L
authors.lastname: Nyberg
authors.affiliation: Faculty of Health, Nutrition and Management, Akershus University College, Kjeller, Norway.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Elind
authors.affiliation: Faculty of Health, Nutrition and Management, Akershus University College, Kjeller, Norway.
authors.forename: Stine M
authors.initials: SM
authors.lastname: Ulven
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D001628:Beverages; D015415:Biomarkers / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood* / Q000517:prevention & control*; D015525:Fatty Acids, Omega-3 / Q000378:metabolism*; D005260:Female; D005395:Fish Oils / Q000737:chemistry*; D005399:Fishes; D005527:Food, Fortified; D064368:Healthy Volunteers; D006801:Humans; D007249:Inflammation; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D012307:Risk Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D008055:Lipids