title: Plasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change.
abstract: OBJECTIVE
  We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change in body weight. Sex, age, and BMI were considered as potential effect modifiers.
  
  
  METHODS
  A total of 1,998 women and men participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a median of 4.9 years. The associations between the proportion of plasma phospholipid long-chain n-3 PUFA and change in weight were investigated using mixed-effect linear regression.
  
  
  RESULTS
  The proportion of long-chain n-3 PUFA was not associated with change in weight. Among all participants, the 1-year weight change was -0.7 g per 1% point higher long-chain n-3 PUFA level (95% confidence interval: -20.7 to 19.3). The results when stratified by sex, age, or BMI groups were not systematically different.
  
  
  CONCLUSIONS
  The results of this study suggest that the proportion of long-chain n-3 PUFA in plasma phospholipids is not associated with subsequent change in body weight within the range of exposure in the general population.
authors.affiliation: Department of Clinical Epidemiology, School of Public Health, Aarhus University, Aarhus University Hospital, Aalborg, Denmark. muj@soci.au.dk
authors.forename: Marianne U
authors.initials: MU
authors.lastname: Jakobsen
authors.forename: Claus
authors.initials: C
authors.lastname: Dethlefsen
authors.forename: Karen M
authors.initials: KM
authors.lastname: Due
authors.forename: Nadia
authors.initials: N
authors.lastname: Slimani
authors.forename: Veronique
authors.initials: V
authors.lastname: Chajès
authors.forename: Anne M
authors.initials: AM
authors.lastname: May
authors.forename: Thorkild I A
authors.initials: TI
authors.lastname: Sørensen
authors.forename: Jytte
authors.initials: J
authors.lastname: Halkjær
authors.forename: Anne
authors.initials: A
authors.lastname: Tjønneland
authors.forename: Francoise
authors.initials: F
authors.lastname: Clavel-Chapelon
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Boutron-Ruault
authors.forename: Guy
authors.initials: G
authors.lastname: Fagherazzi
authors.forename: Birgit
authors.initials: B
authors.lastname: Teucher
authors.forename: Rudolf
authors.initials: R
authors.lastname: Kaaks
authors.forename: Heiner
authors.initials: H
authors.lastname: Boeing
authors.forename: Madlen
authors.initials: M
authors.lastname: Schütze
authors.forename: Antonia
authors.initials: A
authors.lastname: Trichopoulou
authors.forename: Dimosthenis
authors.initials: D
authors.lastname: Zylis
authors.forename: George
authors.initials: G
authors.lastname: Makrygiannis
authors.forename: Domenico
authors.initials: D
authors.lastname: Palli
authors.forename: Amalia
authors.initials: A
authors.lastname: Mattiello
authors.forename: Giovanna
authors.initials: G
authors.lastname: Tagliabue
authors.forename: Daphne L
authors.initials: DL
authors.lastname: van der A
authors.forename: H B
authors.initials: HB
authors.lastname: Bueno-de-Mesquita
authors.forename: Laudina
authors.initials: L
authors.lastname: Rodríguez
authors.forename: Noémie
authors.initials: N
authors.lastname: Travier
authors.forename: Esther
authors.initials: E
authors.lastname: Molina-Montes
authors.forename: José M
authors.initials: JM
authors.lastname: Huerta
authors.forename: Aurelio
authors.initials: A
authors.lastname: Barricarte
authors.forename: Pilar
authors.initials: P
authors.lastname: Amiano
authors.forename: Jonas
authors.initials: J
authors.lastname: Manjer
authors.forename: Elisabet
authors.initials: E
authors.lastname: Wirfält
authors.forename: Ingegerd
authors.initials: I
authors.lastname: Johansson
authors.forename: Göran
authors.initials: G
authors.lastname: Hallmans
authors.forename: Kay-Tee
authors.initials: KT
authors.lastname: Khaw
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Wareham
authors.forename: Francesca
authors.initials: F
authors.lastname: Crowe
authors.forename: Isabelle
authors.initials: I
authors.lastname: Romieu
authors.forename: Elio
authors.initials: E
authors.lastname: Riboli
authors.forename: Petra H M
authors.initials: PH
authors.lastname: Peeters
authors.forename: Kim
authors.initials: K
authors.lastname: Overvad
mesh_terms: D001835:Body Weight / Q000187:drug effects / Q000502:physiology*; D015525:Fatty Acids, Omega-3 / Q000097:blood* / Q000494:pharmacology; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D010743:Phospholipids / Q000097:blood / Q000737:chemistry*; D011446:Prospective Studies
chemical_list: D015525:Fatty Acids, Omega-3; D010743:Phospholipids