title: [Sex difference in performance in elevated plus maze and hippocampal GluR1 level].
abstract: OBJECTIVE
  To explore whether sex difference exists in the performance in each arm of elevated plus maze (EPM) and GluR1 level in the hippocampus of female and male Sprague-Dawley rats.
  
  
  METHODS
  Eleven male and 10 female SD rats were tested for 5 minutes in the EPM. These rats were decapitated 30 min after testing. The left and right hippocampus were dissected. Samples were stored at -80 degree for protein extracting. Western blot was used to detect the GluR1 levels in the hippocampus.
  
  
  RESULTS
  Female rats exhibited less anxiety-like behaviors than male rats in the EPM (P<0.05).Female rats had lower GluR1 levels in total and left hippocampus than those of male rats (P<0.05).
  
  
  CONCLUSIONS
  Sex difference exists between female and male rats in the EPM and hippocampal GluR1.
authors.affiliation: Department of Psychiatry, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Xiang
authors.forename: Wei
authors.initials: W
authors.lastname: Hao
authors.forename: Therese A
authors.initials: TA
authors.lastname: Kosten
mesh_terms: D000818:Animals; D001007:Anxiety / Q000378:metabolism / Q000503:physiopathology*; D001522:Behavior, Animal; D005260:Female; D006624:Hippocampus / Q000378:metabolism* / Q000502:physiology; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018091:Receptors, AMPA / Q000378:metabolism* / Q000502:physiology; D012727:Sex Characteristics
chemical_list: D018091:Receptors, AMPA