title: Carbon dioxide triggered and copper-catalyzed domino reaction: efficient construction of highly substituted 3(2H)-furanones from nitriles and propargylic alcohols.
abstract: A novel carbon dioxide triggered and copper-catalyzed domino reaction for the efficient synthesis of highly substituted 3(2H)-furanones from readily available nitriles and propargylic alcohols has been developed. Carbon dioxide is a prerequisite for achieving the present catalytic transformation, and one of the oxygen atoms of carbon dioxide is incorporated into the 3(2H)-furanones. Nitriles not only act as the reaction solvent but also as the reactant; copper salts play dual roles of activating both the propargylic alcohols and nitriles.
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, PR China.
authors.forename: Chaorong
authors.initials: C
authors.lastname: Qi
authors.forename: Huanfeng
authors.initials: H
authors.lastname: Jiang
authors.forename: Liangbin
authors.initials: L
authors.lastname: Huang
authors.forename: Gaoqing
authors.initials: G
authors.lastname: Yuan
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Ren