title: Monolayer coated gold nanoparticles for delivery applications.
abstract: Gold nanoparticles (AuNPs) provide attractive vehicles for delivery of drugs, genetic materials, proteins, and small molecules. AuNPs feature low core toxicity coupled with the ability to parametrically control particle size and surface properties. In this review, we focus on engineering of the AuNP surface monolayer, highlighting recent advances in tuning monolayer structures for efficient delivery of drugs and biomolecules. This review covers two broad categories of particle functionalization, organic monolayers and biomolecule coatings, and discusses their applications in drug, DNA/RNA, protein and small molecule delivery.
authors.affiliation: Department of Chemistry, University of Massachusetts at Amherst, Amherst, MA-01003, USA.
authors.forename: Subinoy
authors.initials: S
authors.lastname: Rana
authors.forename: Avinash
authors.initials: A
authors.lastname: Bajaj
authors.forename: Rubul
authors.initials: R
authors.lastname: Mout
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Rotello
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D006046:Gold / Q000008:administration & dosage / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D006046:Gold