title: Analgesic and anti-inflammatory activities of Passiflora foetida L.
abstract: OBJECTIVE
  To investigate the analgesic and anti-inflammatory activities of ethanol extract of Passiflora foetida (P. foetida) leaves.
  
  
  METHODS
  Ethanol extract of P. foetida leaf was evaluated for analgesic action by acetic acid-induced writhing and hot plate method in albino mice. The anti-inflammatory property of ethanolic leaf extract was tested by carrageenan induced acute paw edema and histamine induced acute paw edema in rats.
  
  
  RESULTS
  The dose 200 mg/kg of P. foetida leaf extract exhibited highest significant analgesic activity [(13.50±0.43) min] at a reaction time of 20 min in hot plate method in mice. The ethanol extract of leaf dose 100 mg/kg produced a highly significant anti inflammatory effect [(1.302±0.079) mL] in rats.
  
  
  CONCLUSIONS
  It is very clear that P. foetida also has analgesic and anti-inflammatory activities for the pharmaceuticals.
authors.affiliation: Bioprospecting Laboratory, Department of Botany, Bharathiar University, Coimbatore, Tamil Nadu, India.
authors.forename: V
authors.initials: V
authors.lastname: Sasikala
authors.forename: S
authors.initials: S
authors.lastname: Saravanan
authors.forename: T
authors.initials: T
authors.lastname: Parimelazhagan
mesh_terms: D019342:Acetic Acid / Q000009:adverse effects; D000700:Analgesics / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000627:therapeutic use; D002351:Carrageenan / Q000009:adverse effects; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D000431:Ethanol / Q000737:chemistry; D006358:Hot Temperature / Q000009:adverse effects; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement; D029598:Passiflora / Q000737:chemistry*; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D000431:Ethanol; D002351:Carrageenan; D019342:Acetic Acid