title: Intraocular ALλ amyloidoma with plasma cell neoplasia in a cat.
abstract: An 11-year-old, neutered male domestic short-hair cat was presented with buphthalmos of the right eye and diagnosed with advanced glaucoma. Sonographic examination revealed an iridial thickening. Neoplasia was suspected and an enucleation was performed. Histopathology of the enucleated eye revealed abundant amyloid deposition predominantly in the anterior uveal tract accompanied by few to moderate numbers of well-differentiated plasma cells. The amyloid deposits were identified by staining with Congo red and showing green birefringence under polarized light. Immunohistochemically, amyloid and plasma cells stained intensely only with anti-ALλ antibody, supporting the amyloid tumor being an immunoglobulin-λ-light chain origin. Additional abnormalities included narrowing of the filtration angle and collapse of the ciliary cleft, and trabecular meshwork. One year post-enucleation, the cat was still healthy without signs of systemic amyloidosis or apparent metastatic disease. This is the first report of a cat with noncutaneous extramedullary plasmacytoma originating in the anterior uveal tract with resulting local amyloid.
authors.affiliation: Department of Veterinary Pathology, Freie Universität Berlin, Robert-von-Ostertag-Strasse 15, 14163 Berlin, Germany.
authors.forename: Olivia
authors.initials: O
authors.lastname: Kershaw
authors.forename: Jens
authors.initials: J
authors.lastname: Linek
authors.forename: Reinhold P
authors.initials: RP
authors.lastname: Linke
authors.forename: Achim D
authors.initials: AD
authors.lastname: Gruber
mesh_terms: D000686:Amyloidosis / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D002371:Cat Diseases / Q000175:diagnosis / Q000473:pathology*; D002415:Cats; D005134:Eye Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D007142:Immunoglobulin gamma-Chains / Q000378:metabolism*; D008297:Male; D054219:Neoplasms, Plasma Cell / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D014602:Uvea / Q000473:pathology
chemical_list: D007142:Immunoglobulin gamma-Chains