title: GST polymorphisms are associated with hepatocellular carcinoma risk in Chinese population.
abstract: OBJECTIVE
  To investigate the association between GSTM1 and GSTT1 polymorphisms and the risk of hepatocellular carcinoma (HCC) in Chinese population.
  
  
  METHODS
  Literature databases including PubMed, ISI web of science and other databases were searched. Pooled odds ratio (OR) and 95% CI were calculated using random- or fixed- effects model. Subgroup analysis and sensitivity analysis were also performed.
  
  
  RESULTS
  Nineteen studies of GSTM1 (2660 cases and 4017 controls) and 16 studies of GSTT1 (2410 cases and 3669 controls) were included. The GSTM1/GSTT1 null genotypes were associated with increased risk of HCC in Chinese population (for GSTM1, OR = 1.487, 95% CI: 1.159 to 1.908, P = 0.002; for GSTT1, OR = 1.510, 95% CI: 1.236 to 1.845, P = 0.000). No publication bias was detected. In subgroup analysis, glutathione S-transferases polymorphisms were significantly associated with HCC risk among the subjects living in high-incidence areas, but not among the subjects living in low-incidence areas.
  
  
  CONCLUSIONS
  The present meta-analysis suggests that GSTM1/GSTT1 null genotypes are associated with increased risk of HCC in Chinese population.
authors.affiliation: Department of Infectious Disease, the Fourth Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Yu
authors.forename: Chun-Yu
authors.initials: CY
authors.lastname: Wang
authors.forename: Bo
authors.initials: B
authors.lastname: Xi
authors.forename: Lei
authors.initials: L
authors.lastname: Sun
authors.forename: Ruo-Qi
authors.initials: RQ
authors.lastname: Wang
authors.forename: Yin-Kun
authors.initials: YK
authors.lastname: Yan
authors.forename: Li-Ying
authors.initials: LY
authors.lastname: Zhu
mesh_terms: D044466:Asian People; D006528:Carcinoma, Hepatocellular / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008113:Liver Neoplasms / Q000208:ethnology / Q000235:genetics*; D015233:Models, Statistical; D016017:Odds Ratio; D011110:Polymorphism, Genetic
chemical_list: D005982:Glutathione Transferase; C413545:glutathione S-transferase T1