title: Preliminary evaluation of therapeutic ion release from Sr-doped zinc-silicate glass ceramics.
abstract: Bioactive and degradable porous bioceramics play an important role in many clinical situations. Porosity is essential to the performance of a material that is proposed to be used as an implantable osseous scaffold. Scaffolds provide a three dimensional support and template to osseous integration and vascularization. Combining the porosity of a scaffold with the ability of the scaffold material to deliver therapeutic ions to the site of implantation goes some way towards developing an ideal bone graft. A series of strontium-doped zinc silicate (Ca-Sr-Na-Zn-Si) glass ceramics scaffoldswere developed, whose porosity was measured to be between 93% and 96%, which is advantageous in terms of osseous integration and vascularization. The levels of Zn(2+) and Sr(2+) detected as a result of degradation of the crystalline phases were found to be 1.4-600 parts per million (ppm) and 0-583 ppm, respectively. The levels detected correlate well with the levels of Sr(2+) and Zn(2+)ions typically associated with clinical benefits, including antibacterial efficacy, osteoblastic differentiation and impaired osteoclastic resorption.
authors.affiliation: Cork Institute of Technology, Ireland.
authors.forename: Mark
authors.initials: M
authors.lastname: Looney
authors.forename: Helen
authors.initials: H
authors.lastname: O'Shea
authors.forename: Daniel
authors.initials: D
authors.lastname: Boyd
mesh_terms: D002516:Ceramics; D004337:Drug Carriers; D005898:Glass; D010316:Particle Size; D017640:Silicates; D012995:Solubility; D013324:Strontium; D054457:Tissue Scaffolds; D014056:Tomography, X-Ray; D014961:X-Ray Diffraction
chemical_list: D004337:Drug Carriers; D017640:Silicates; D013324:Strontium