title: Current pharmacological approaches and perspectives in the treatment of geriatric mood disorders.
abstract: OBJECTIVE
  This work aims to review the most recent developments in the treatment of mood disorders (major depression and bipolar disorder) in the elderly.
  
  
  RESULTS
  In the last years, few new pharmacological interventions for mood disorders have been developed. Recent studies seek to provide alternative treatment strategies to achieve higher remission rates, including the association of antidepressants, mood stabilizers and psychotherapy and the treatment of specific clusters of symptoms, such as the adjunctive treatment of cognitive impairment with cholinesterase inhibitors. Also, recent studies have been assessing the potential of pharmacogenetic information in the prediction of treatment outcomes.
  
  
  CONCLUSIONS
  These factors altogether are expected to help the development of personalized treatment strategies that may improve outcomes with fewer adverse effects.
authors.affiliation: Laboratory of Neuroscience, Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil. brenosatler@usp.br
authors.forename: Breno S
authors.initials: BS
authors.lastname: Diniz
authors.forename: Paula V
authors.initials: PV
authors.lastname: Nunes
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Machado-Vieira
authors.forename: Orestes V
authors.initials: OV
authors.lastname: Forlenza
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000188:drug therapy*; D006801:Humans; D019964:Mood Disorders / Q000188:drug therapy*