title: IFN-γ 874A>T genotype is associated with higher CCR5 expression in peripheral blood mononuclear cells from HIV+ patients.
abstract: We previously showed that certain cytokines impact on the expression of drug transporters and chemokine receptors in peripheral blood mononuclear cells. Known single-nucleotide polymorphism genes in the genes encoding interferon γ (874A>T, rs62559044) and interleukin 2 (-330T>G, rs2069763) were genotyped in 66 HIV+ patients, and the impact of single-nucleotide polymorphisms on expression of ABCB1, ABCC1, ABCC2, CXCR4, and CCR5 in peripheral blood mononuclear cells from HIV+ patients was assessed. The IFN-γ 874A>T allele and viral load were independently associated with CCR5 expression in patients. These associations have potential implications for HIV disease progression and treatment response that now warrant further study.
authors.affiliation: NIHR Biomedical Research Centre, Royal Liverpool & Broadgreen University Hospitals Trust, Liverpool, United Kingdom.
authors.forename: Neill J
authors.initials: NJ
authors.lastname: Liptrott
authors.forename: Deirdre
authors.initials: D
authors.lastname: Egan
authors.forename: David J
authors.initials: DJ
authors.lastname: Back
authors.forename: Andrew
authors.initials: A
authors.lastname: Owen
mesh_terms: D000483:Alleles; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology*; D005838:Genotype; D015658:HIV Infections / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008297:Male; D000089762:Multidrug Resistance-Associated Protein 2; D020641:Polymorphism, Single Nucleotide; D019713:Receptors, CCR5 / Q000235:genetics / Q000378:metabolism*
chemical_list: C000715087:ABCC2 protein, human; D000089762:Multidrug Resistance-Associated Protein 2; D019713:Receptors, CCR5; D007371:Interferon-gamma