title: Association between reproductive factors and breast cancer in an urban set up at central India: a case-control study.
abstract: BACKGROUND
  Epigenetic changes, geography and environmental factors do surpass the genetic factors in the development of breast cancer. This study investigates the association of reproductive factors with the breast cancer in this context.
  
  
  OBJECTIVE
  To detect the association of reproductive risk factors with breast cancer in an urban set up at central India.
  
  
  METHODS
  Matched paired community-based case-control study.
  
  
  METHODS
  The study was conducted for a period of a year from October 2008 to August 2009 in Bhopal (MP). Demographic data and reproductive risk factor related information were collected using structured questionnaire. Data analysis was done by Epi-info and SPSS 16.
  
  
  RESULTS
  History of using oral contraceptive pills (OR = 3.02, 95% CI: 1.28-7.11), history of not having breastfeeding (OR = 3.62, 95% CI: 1.29-10.16) and family history of breast cancer (OR = 3.98, 95%CI: 1.06-14.826) were associated significantly with the occurrence of breast cancer in multivariate analysis.
  
  
  CONCLUSIONS
  The findings of the present study suggests that positive family history of breast cancer and history of using OCP may be the epigenetic factors promoting the occurrence of breast cancer while breastfeeding reduces the possibility of acquiring breast cancer.
authors.affiliation: Department of Community Medicine, LN Medical College and Research Centre, Bhopal, India. drramalodha@gmail.com
authors.forename: R
authors.initials: R
authors.lastname: Lodha
authors.forename: A
authors.initials: A
authors.lastname: Joshi
authors.forename: D
authors.initials: D
authors.lastname: Paul
authors.forename: K M
authors.initials: KM
authors.lastname: Lodha
authors.forename: N
authors.initials: N
authors.lastname: Nahar
authors.forename: A
authors.initials: A
authors.lastname: Shrivastava
authors.forename: V K
authors.initials: VK
authors.lastname: Bhagat
authors.forename: S
authors.initials: S
authors.lastname: Nandeshwar
mesh_terms: D000328:Adult; D001942:Breast Feeding / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000235:genetics; D016022:Case-Control Studies; D002648:Child; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008875:Middle Aged; D012098:Reproduction / Q000235:genetics; D017584:Reproductive History; D012307:Risk Factors; D014505:Urban Population
chemical_list: D003278:Contraceptives, Oral, Hormonal