title: Risk factors for colorectal anastomotic stenoses and their impact on quality of life: what are the lessons to learn?
abstract: OBJECTIVE
  The aim of the study was to analyse the incidence of benign colorectal anastomotic stenoses in consecutive patients operated on in a single institution and to assess risk factors for their development. Their impact on quality of life was also evaluated.
  
  
  METHODS
  Patient characteristics, indications for surgery, surgical technique and postoperative complications were prospectively recorded. Stenosis was evaluated by rectoscopy at regular intervals, and patients were treated only if symptomatic. After at least 6 months following surgery, patients were asked to respond to the Short Form 36-item quality-of-life questionnaire during a telephone interview.
  
  
  RESULTS
  Of the original 211 patients considered, 195 underwent a follow-up rectoscopy and were included in the study. Benign stenosis were found in 26 (13%), and 19 (73%) symptomatic patients were treated successfully (15 with endoscopic dilatation and four with radial diathermic surgical incisions). Risk factors for anastomotic stenosis according to univariate analysis were female sex, diverticulitis, mechanical anastomosis, and anastomosis located between 8 and 12 cm from the anal verge. The significant risk factors identified by multivariate analysis were diverticulitis (OR 5, P=0.002) and mechanical anastomosis (OR 9, P=0.04). The self-perceived quality of life of patients with stenosis was significantly worse compared with controls.
  
  
  CONCLUSIONS
  Since diverticulitis and mechanical anastomosis are risk factors for anastomotic stenosis, surgeons should take this into account when they are considering what type of anastomotic technique to utilize.
authors.affiliation: Department of Surgical and Gastroenterological Sciences, 1st Surgical Clinic, Coloproctology Unit, Ospedale S. Antonio, Padova, Italy. linopolese@hotmail.com
authors.forename: L
authors.initials: L
authors.lastname: Polese
authors.forename: M
authors.initials: M
authors.lastname: Vecchiato
authors.forename: A C
authors.initials: AC
authors.lastname: Frigo
authors.forename: G
authors.initials: G
authors.lastname: Sarzo
authors.forename: R
authors.initials: R
authors.lastname: Cadrobbi
authors.forename: R
authors.initials: R
authors.lastname: Rizzato
authors.forename: A
authors.initials: A
authors.lastname: Bressan
authors.forename: S
authors.initials: S
authors.lastname: Merigliano
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000714:Anastomosis, Surgical; D003082:Colectomy; D003106:Colon / Q000601:surgery*; D003108:Colonic Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D003251:Constriction, Pathologic / Q000453:epidemiology / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D010535:Laparoscopy; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D011446:Prospective Studies; D011788:Quality of Life; D012002:Rectal Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D012007:Rectum / Q000601:surgery*; D012307:Risk Factors; D011795:Surveys and Questionnaires