title: Prostate MRI: diffusion-weighted imaging at 1.5T correlates better with prostatectomy Gleason Grades than TRUS-guided biopsies in peripheral zone tumours.
abstract: OBJECTIVE
  To investigate the usefulness of Apparent Diffusion Coefficients (ADC) in predicting prostatectomy Gleason Grades (pGG) and Scores (GS), compared with ultrasound-guided biopsy Gleason Grades (bGG).
  
  
  METHODS
  Twenty-four patients with biopsy-proven prostate cancer were included in the study. Diffusion-weighted images were obtained using 1.5-T MR with a pelvic phased-array coil. Median ADC values (b0,500,1000 s/mm²) were measured at the most suspicious areas in the peripheral zone. The relationship between ADC values and pGG or GS was assessed using Pearson's coefficient. The relationship between bGG and pGG or GS was also evaluated. Receiver operating characteristic (ROC) curve analysis was performed to assess the performance of each method on a qualitative level.
  
  
  RESULTS
  A significant negative correlation was found between mean ADCs of suspicious lesions and their pGG (r = -0.55; p < 0.01) and GS (r = -0.63; p < 0.01). No significant correlation was found between bGG and pGG (r = 0.042; p > 0.05) or GS (r = 0.048; p > 0.05). ROC analysis revealed a discriminatory performance of AUC = 0.82 for ADC and AUC = 0.46 for bGG in discerning low-grade from intermediate/high-grade lesions.
  
  
  CONCLUSIONS
  The ADC values of suspicious areas in the peripheral zone perform better than bGG in the correlation with prostate cancer aggressiveness, although with considerable intra-subject heterogeneity.
  
  
  CONCLUSIONS
  • Prostate cancer aggressiveness is probably underestimated and undersampled by routine ultrasound-guided biopsies. • Diffusion-weighted MR images show good linear correlation with prostate cancer aggressiveness. • DWI information may be used to improve risk-assessment in prostate cancer.
authors.affiliation: CDPI Clinics-Abdominal and Pelvic Imaging, Rio de Janeiro Federal University, Av. Das Americas, 4666, sl 325, centro medico, 22640102, Rio de Janeiro, RJ, Brazil. lkayat@gmail.com
authors.forename: Leonardo Kayat
authors.initials: LK
authors.lastname: Bittencourt
authors.forename: Jelle O
authors.initials: JO
authors.lastname: Barentsz
authors.forename: Luiz Carlos Duarte
authors.initials: LC
authors.lastname: de Miranda
authors.forename: Emerson Leandro
authors.initials: EL
authors.lastname: Gasparetto
mesh_terms: D000368:Aged; D019540:Area Under Curve; D001706:Biopsy / Q000379:methods; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011467:Prostate / Q000000981:diagnostic imaging / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000096:biosynthesis; D011468:Prostatectomy / Q000379:methods; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery* / Q000628:therapy; D012372:ROC Curve; D015203:Reproducibility of Results; D014463:Ultrasonography / Q000379:methods*; D036761:Ultrasound, High-Intensity Focused, Transrectal / Q000379:methods*
chemical_list: D017430:Prostate-Specific Antigen