title: Safeguarding genetic information in Drosophila.
abstract: Eukaryotic cells employ a plethora of conserved proteins and mechanisms to ensure genome integrity. In metazoa, these mechanisms must operate in the context of organism development. This mini-review highlights two emerging features of DNA damage responses in Drosophila: a crosstalk between DNA damage responses and components of the spindle assembly checkpoint, and increasing evidence for the effect of DNA damage on the developmental program at multiple points during the Drosophila life cycle.
authors.affiliation: MCD Biology, University of Colorado, Boulder, USA. tin.su@colorado.edu
authors.forename: Tin Tin
authors.initials: TT
authors.lastname: Su
mesh_terms: D000818:Animals; D002453:Cell Cycle; D004249:DNA Damage; D004330:Drosophila / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D059566:M Phase Cell Cycle Checkpoints
chemical_list: D029721:Drosophila Proteins