title: The inflammatory tumor microenvironment, epithelial mesenchymal transition and lung carcinogenesis.
abstract: The inflammatory tumor microenvironment (TME) has many roles in tumor progression and metastasis, including creation of a hypoxic environment, increased angiogenesis and invasion, changes in expression of microRNAs (miRNAs) and an increase in a stem cell phenotype. Each of these has an impact on epithelial mesenchymal transition (EMT), particularly through the downregulation of E-cadherin. Here we review seminal work and recent findings linking the role of inflammation in the TME, EMT and lung cancer initiation, progression and metastasis. Finally, we discuss the potential of targeting aspects of inflammation and EMT in cancer prevention and treatment.
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, 37-131 CHS Building, Los Angeles, CA, 90095, USA.
authors.forename: Eileen L
authors.initials: EL
authors.lastname: Heinrich
authors.forename: Tonya C
authors.initials: TC
authors.lastname: Walser
authors.forename: Kostyantyn
authors.initials: K
authors.lastname: Krysan
authors.forename: Elvira L
authors.initials: EL
authors.lastname: Liclican
authors.forename: Jeanette L
authors.initials: JL
authors.lastname: Grant
authors.forename: Nicole L
authors.initials: NL
authors.lastname: Rodriguez
authors.forename: Steven M
authors.initials: SM
authors.lastname: Dubinett