title: Association between maternal prenatal vitamin use and congenital abnormalities of the genitourinary tract in a developing country.
abstract: OBJECTIVE
  To determine the association between prenatal multivitamin supplementation and congenital genitourinary tract anomalies in a group of Colombian newborn babies included in the Latin-American surveillance program (ECLAMC).
  
  
  METHODS
  We included all neonates born between January 2004 and August 2007 registered in the ECLAMC database. Maternal prenatal multivitamin use was assessed for 122 newborns with congenital genitourinary tract anomalies and then compared to 271 non-malformed controls.
  
  
  RESULTS
  46,850 births were registered and 122 (26/10,000) of them were identified to have a genitourinary tract anomaly. Prenatal multivitamin supplementation during the first, second, and third trimesters of pregnancy was associated with a reduction in the risk of these anomalies: OR 0.16 (0.08-0.31), OR 0.31 (0.19-0.52), and OR 0.38 (0.23-0.63) respectively.
  
  
  CONCLUSIONS
  Maternal prenatal multivitamins may reduce the risk of congenital genitourinary tract anomalies, not only during the first 8 weeks of gestation but also later in pregnancy, in developing countries.
authors.affiliation: Human Genetics Institute, San Ignacio University Hospital, Pontificia Universidad Javeriana, Colombia. nicolasfernandezb@gmail.com
authors.forename: Nicolás
authors.initials: N
authors.lastname: Fernández
authors.forename: Juanita
authors.initials: J
authors.lastname: Henao-Mejía
authors.forename: Pedro
authors.initials: P
authors.lastname: Monterrey
authors.forename: Jaime
authors.initials: J
authors.lastname: Pérez
authors.forename: Ignacio
authors.initials: I
authors.lastname: Zarante
mesh_terms: D000328:Adult; D003105:Colombia / Q000453:epidemiology; D003906:Developing Countries; D019587:Dietary Supplements; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications; D011295:Prenatal Care / Q000379:methods*; D011296:Prenatal Diagnosis; D012189:Retrospective Studies; D012307:Risk Factors; D014564:Urogenital Abnormalities / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control*; D014815:Vitamins / Q000008:administration & dosage*
chemical_list: D014815:Vitamins