title: A 5-year-old boy with atrophic autoimmune thyroiditis caused by thyroid-stimulation blocking antibodies.
abstract: A 5-year-old boy was presented for a growth disturbance, which was initially noted at 3 years of age. Endocrinological testing identified severe hypothyroidism, defined by the following levels: TSH 990.5 microU/mL, F-T3 0.26 pg/mL, and F-T4 0.09 ng/dL. Serum anti-thyroid peroxidase (TPO) antibodies were 158 IU/mL and serum thyroid-stimulation blocking antibodies (TSBab) levels were 82.1 IU/mL (normal range < 45.6). Thyroid scintigraphy with 99mTc showed markedly decreased uptake, and magnetic resonance imaging (MRI) revealed pituitary hyperplasia. He was diagnosed with atrophic autoimmune thyroiditis. His thyroid function and pituitary size normalized following thyroid hormone replacement therapy. We report a rare case of a young boy with atrophic thyroiditis caused by TSBab.
authors.affiliation: Department of General Pediatrics, Nihon University, Nerima-Hikarigaoka Hospital, Nerima-ku, Tokyo, Japan. y-inamo@pb3.so-net.ne.jp
authors.forename: Yasuji
authors.initials: Y
authors.lastname: Inamo
mesh_terms: D019138:Antibodies, Blocking / Q000032:analysis*; D002657:Child Development / Q000187:drug effects; D002675:Child, Preschool; D006130:Growth Disorders / Q000209:etiology / Q000276:immunology; D020249:Hormone Replacement Therapy; D006801:Humans; D007037:Hypothyroidism / Q000209:etiology / Q000276:immunology; D008297:Male; D013961:Thyroid Gland / Q000276:immunology*; D013967:Thyroiditis, Autoimmune / Q000188:drug therapy / Q000276:immunology* / Q000503:physiopathology; D013974:Thyroxine / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D019138:Antibodies, Blocking; D013974:Thyroxine