title: Case of primary localized cutaneous amyloidosis with protean clinical manifestations: lichen, poikiloderma-like, dyschromic and bullous variants.
abstract: Primary localized cutaneous amyloidosis (PLCA) commonly presents as macular and lichen variants. We present a case of a 27-year-old Chinese woman with cutaneous features of the rarely reported poikiloderma-like, dyschromic and bullous forms of PLCA, and the commoner lichen variant. There were no syndromic associations or systemic involvement, and the various morphological subtypes occurred in isolation from one another. We review the clinical spectrum of PLCA, highlight its protean clinical manifestations in this patient, and discuss its postulated pathogenesis in relation to its histopathological features.
authors.affiliation: National Skin Centre, Singapore, Singapore.
authors.forename: Nisha Suyien
authors.initials: NS
authors.lastname: Chandran
authors.affiliation: National Skin Centre, Singapore, Singapore.
authors.forename: Boon-Kee
authors.initials: BK
authors.lastname: Goh
authors.affiliation: National Skin Centre, Singapore, Singapore.
authors.forename: Siong-See
authors.initials: SS
authors.lastname: Lee
authors.affiliation: National Skin Centre, Singapore, Singapore.
authors.forename: Chee-Leok
authors.initials: CL
authors.lastname: Goh
mesh_terms: D000328:Adult; D000686:Amyloidosis / Q000473:pathology*; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000473:pathology; D017512:Lichenoid Eruptions / Q000473:pathology; D058225:Plaque, Amyloid / Q000473:pathology; D012871:Skin Diseases / Q000473:pathology*; D012872:Skin Diseases, Vesiculobullous / Q000473:pathology