title: Influence of selenium on hepatic mitochondrial antioxidant capacity in ducklings intoxicated with aflatoxin B₁.
abstract: The aim of the study was to investigate the effect of selenium on hepatic mitochondrial antioxidant capacity in ducklings administrated with aflatoxin B(1) (AFB(1)). Ninety 7-day-old ducklings were randomly divided into three groups (groups I-III). Group I was used as a blank control. Group II was administered with AFB(1) (0.1 mg/kg body weight). Group III was administered with AFB(1) (0.1 mg/kg body weight) plus selenium (sodium selenite, 1 mg/kg body weight). All treatments were given once daily for 21 days. The results showed that the activities of mitochondrial superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and glutathione reductase (GR) in group II ducklings significantly decreased when compared with group I (P < 0.01). Furthermore, the content of hepatic mitochondrial malondialdehyde (MDA) significantly increased (P < 0.01). However, the activities of hepatic mitochondrial SOD, CAT, GSH-Px, and GR in group III ducklings significantly increased when compared with group II (P < 0.05). In addition, the content of hepatic mitochondrial MDA significantly decreased (P < 0.01). These results revealed that AFB(1) significantly induced hepatic mitochondrial antioxidant dysfunction. However, sodium selenite could significantly ameliorate the negative effect induced by AFB(1).
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
authors.forename: Dayou
authors.initials: D
authors.lastname: Shi
authors.forename: Shining
authors.initials: S
authors.lastname: Guo
authors.forename: Shenquan
authors.initials: S
authors.lastname: Liao
authors.forename: Rongsheng
authors.initials: R
authors.lastname: Su
authors.forename: Jiaqiang
authors.initials: J
authors.lastname: Pan
authors.forename: Yuanchao
authors.initials: Y
authors.lastname: Lin
authors.forename: Zhaoxin
authors.initials: Z
authors.lastname: Tang
mesh_terms: D016604:Aflatoxin B1 / Q000506:poisoning* / Q000633:toxicity; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D004372:Ducks; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D008315:Malondialdehyde; D016604:Aflatoxin B1; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase