title: 'Omic' genetic technologies for herbal medicines in psychiatry.
abstract: The field of genetics, which includes the use of 'omic' technologies, is an evolving area of science that has emerging application in phytotherapy. Omic studies include pharmacogenomics, proteomics and metabolomics. Herbal medicines, as monotherapies, or complex formulations such as traditional Chinese herbal prescriptions, may benefit from omic studies, and this new field may be termed 'herbomics'. Applying herbomics in the field of psychiatry may provide answers about which herbal interventions may be effective for individuals, which genetic processes are triggered, and the subsequent neurochemical pathways of activity. The use of proteomic technology can explore the differing epigenetic effects on neurochemical gene expression between individual herbs, isolated constituents and complex formulae. The possibilities of side effects or insufficient response to the herb can also be assessed via pharmacogenomic analysis of polymorphisms of cytochrome P450 liver enzymes or P-glycoprotein. While another novel application of omic technology is for the validation of the concept of synergy in individual herbal extracts and prescriptive formulations. Chronic administration of psychotropic herbal medicines may discover important effects on chromatin remodelling via modification of histone and DNA methylation. This paper focuses on the emerging field of herbomics, and is to our knowledge the first publication to explore this in the area of psychiatry.
authors.affiliation: Professorial Unit, The Melbourne Clinic, Department of Psychiatry, University of Melbourne, Australia. jsarris@unimelb.edu.au
authors.forename: Jerome
authors.initials: J
authors.lastname: Sarris
authors.forename: Chee Hong
authors.initials: CH
authors.lastname: Ng
authors.forename: Isaac
authors.initials: I
authors.lastname: Schweitzer
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000378:metabolism; D016208:Databases, Factual; D015870:Gene Expression; D029001:Herbal Medicine; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D010597:Pharmacogenetics / Q000379:methods*; D008517:Phytotherapy; D011110:Polymorphism, Genetic; D040901:Proteomics; D011619:Psychotropic Drugs / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D011619:Psychotropic Drugs; D003577:Cytochrome P-450 Enzyme System