title: A fast and efficient one-pot microwave assisted synthesis of variously di-substituted 1,2,4-oxadiazoles.
abstract: A one-pot two-step microwave assisted synthesis of variously disubstituted 1,2,4-oxadiazoles from carboxylic acids and amidoximes is reported. This methodology is characterized by short reaction times, is versatile, robust and high-yielding and allows for the preparation of heterocycles with a stereocenter with 100% enantiomeric purity.
authors.affiliation: Dipartimento di Chimica, Università degli Studi di Sassari, Via Vienna 2, 07100, Sassari, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Porcheddu
authors.forename: Roberta
authors.initials: R
authors.lastname: Cadoni
authors.forename: Lidia
authors.initials: L
authors.lastname: De Luca
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry; D008872:Microwaves; D015394:Molecular Structure; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D010091:Oximes / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D002264:Carboxylic Acids; D010069:Oxadiazoles; D010091:Oximes