title: [Susceptibility of pandemic influenza virus A 2009 H1N1 and highly pathogenic avian influenza virus A H5N1 to antiinfluenza agents in cell culture].
abstract: The data on cytotoxicity and antiviral activity of commercial antivirals, such as Remantadine, Oseltamivir, Arbidol and Ribavirin in the MDCK cell culture infected with highly pathogenic (H5N1) and pandemic 2009 (H1N1) influenza A viruses are presented. The study of the antiviral activity of antivirals in the MDCK cells culture demonstrated that Arbidol, Rimantadine and Ribavirin efficiently inhibited reproduction of the highly pathogenic H5N1 influenza viruses isolated from sick birds. Arbidol and Oseltamivir carboxylate selectively inhibited reproduction of the pandemic 2009 H1N1 influenza A viruses with changed specificity to the cell receptors, causing severe influenza in men, while remantadine had no effect on their reproduction.
authors.forename: I T
authors.initials: IT
authors.lastname: Fediakina
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Shchelkanov
authors.forename: P G
authors.initials: PG
authors.lastname: Deriabin
authors.forename: I A
authors.initials: IA
authors.lastname: Leneva
authors.forename: N V
authors.initials: NV
authors.lastname: Gudova
authors.forename: T V
authors.initials: TV
authors.lastname: Kondrat'eva
authors.forename: D K
authors.initials: DK
authors.lastname: L'vov
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001717:Birds; D002460:Cell Line; D024882:Drug Resistance, Viral / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000494:pharmacology* / Q000627:therapeutic use; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects*; D053124:Influenza A Virus, H5N1 Subtype / Q000187:drug effects*; D005585:Influenza in Birds / Q000188:drug therapy*; D007251:Influenza, Human / Q000188:drug therapy*; D053139:Oseltamivir / Q000494:pharmacology* / Q000627:therapeutic use; D012254:Ribavirin / Q000494:pharmacology* / Q000627:therapeutic use; D012299:Rimantadine / Q000494:pharmacology* / Q000627:therapeutic use; D014779:Virus Replication / Q000187:drug effects; D013440:Sulfides
chemical_list: D000998:Antiviral Agents; D007211:Indoles; D053139:Oseltamivir; D012254:Ribavirin; D012299:Rimantadine; C086979:umifenovir; D013440:Sulfides