title: Diagnostic performance of combined noninvasive coronary angiography and myocardial perfusion imaging using 320-MDCT: the CT angiography and perfusion methods of the CORE320 multicenter multinational diagnostic study.
abstract: OBJECTIVE
  Coronary MDCT angiography has been shown to be an accurate noninvasive tool for the diagnosis of obstructive coronary artery disease (CAD). Its sensitivity and negative predictive value for diagnosing percentage of stenosis are unsurpassed compared with those of other noninvasive testing methods. However, in its current form, it provides no information regarding the physiologic impact of CAD and is a poor predictor of myocardial ischemia. CORE320 is a multicenter multinational diagnostic study with the primary objective to evaluate the diagnostic accuracy of 320-MDCT for detecting coronary artery luminal stenosis and corresponding myocardial perfusion deficits in patients with suspected CAD compared with the reference standard of conventional coronary angiography and SPECT myocardial perfusion imaging.
  
  
  CONCLUSIONS
  We aim to describe the CT acquisition, reconstruction, and analysis methods of the CORE320 study.
authors.affiliation: Department of Medicine, Division of Cardiology, Johns Hopkins University School Medicine, 600 N Wolfe St, Carnegie Bldg 565C, Baltimore, MD 21287, USA. rgeorge3@jhmi.edu
authors.forename: Richard T
authors.initials: RT
authors.lastname: George
authors.forename: Armin
authors.initials: A
authors.lastname: Arbab-Zadeh
authors.forename: Rodrigo J
authors.initials: RJ
authors.lastname: Cerci
authors.forename: Andrea L
authors.initials: AL
authors.lastname: Vavere
authors.forename: Kakuya
authors.initials: K
authors.lastname: Kitagawa
authors.forename: Marc
authors.initials: M
authors.lastname: Dewey
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Rochitte
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Arai
authors.forename: Narinder
authors.initials: N
authors.lastname: Paul
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Rybicki
authors.forename: Albert C
authors.initials: AC
authors.lastname: Lardo
authors.forename: Melvin E
authors.initials: ME
authors.lastname: Clouse
authors.forename: Joao A C
authors.initials: JA
authors.lastname: Lima
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D017023:Coronary Angiography / Q000379:methods*; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D005080:Exercise Test; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D019275:Radiopharmaceuticals