title: Studies on synthetic and structural characterization of new fluorine substituted phthalides of pharmaceutical interest.
abstract: An efficient and economical synthesis of some new fluorine substituted phthalides was accomplished from two γ-keto acids, 2-(4-fluorobenzoyl)benzoic acid and 2-(3,5-dinitro-4-flurobenzoyl)benzoic acid. Each acid was reacted with various phenolic compounds in presence of catalytic quantity of concentrated sulphuric acid to get the phthalides. The structures of the synthesized compounds were established on the basis of their elemental analysis, spectral data and chemical reactions. Some of the synthesized phthalides exhibited antibacterial and antifungal activity on antimicrobial screening against human pathogenic bacteria and fungi.
authors.affiliation: Department of Chemistry, H.N.B. Garhwal University, Srinagar (Garhwal), Uttarakhand, India.
authors.forename: Tanu
authors.initials: T
authors.lastname: Chamoli
authors.forename: M S M
authors.initials: MS
authors.lastname: Rawat
authors.forename: Melissa
authors.initials: M
authors.lastname: Jacob
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002384:Catalysis; D005461:Fluorine / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010795:Phthalic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013057:Spectrum Analysis / Q000379:methods
chemical_list: D000890:Anti-Infective Agents; D010795:Phthalic Acids; D005461:Fluorine