title: Road to remission: a comprehensive review of therapy in uveitis.
abstract: BACKGROUND
  Although uveitis remains the third leading cause of preventable blindness in the US, the care and management of patients with uveitis and ocular inflammatory disease sit poised to make evolutionary if not revolutionary changes in the years ahead. This review serves to highlight important advances in the pharmacologic options available for the treatment of uveitis and ocular inflammation.
  
  
  METHODS
  Advances in steroid therapy (both topical and extended delivery), updates in the clinical safety of systemic immune modulation, and the emerging therapies for uveitis and ocular inflammatory disease are some of the areas covered in this review.
  
  
  CONCLUSIONS
  Corticosteroids have been the mainstay in the care of patients with ocular inflammatory disorders for many years. Indeed, some physicians still use only steroids for treating inflamed eyes. However, the mission is remission of all corticosteroids in order to prevent the complications associated with long-term corticosteroid use. The goal is to achieve quiescence through aggressive use of corticosteroids to extinguish the fire and then move along to achieve steroid-free remission through immunosuppressant agents.
authors.affiliation: Massachusetts Eye Research and Surgery Institution, 5 Cambridge Center, 8th floor, Cambridge, MA 02412 , USA. sfoster@mersi.com
authors.forename: Sana S
authors.initials: SS
authors.lastname: Siddique
authors.forename: Rajiv
authors.initials: R
authors.lastname: Shah
authors.forename: Ana M
authors.initials: AM
authors.lastname: Suelves
authors.forename: Charles Stephen
authors.initials: CS
authors.lastname: Foster
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects* / Q000627:therapeutic use*; D000818:Animals; D002986:Clinical Trials as Topic; D005123:Eye / Q000187:drug effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D012074:Remission Induction; D014605:Uveitis / Q000188:drug therapy*
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents