title: Analgesic activity of the aqueous seed extract of Hunteria umbellata (K. Schum.) Hallier f. in rodents.
abstract: The analgesic effect and possible mechanism(s) of action of 50-200 mg/kg of the aqueous seed extract of H. umbellata (HU) were investigated in different experimental models of analgesia using the tail flick, tail immersion, acetic acid-induced writhing tests and formalin-induced algesia. Oral pre-treatment with 50-200 mg/kg of HU caused significant and dose related analgesic effect in the treated rats in all the experimental models used. This analgesia was mediated via central and peripheral mechanisms. Overall, the results showed that HU possesses analgesic effect which lends support to its folkloric use in the local management of pain.
authors.affiliation: Department of Pharmacology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Idi-Araba, Lagos State, Nigeria. ooadey@yahoo.com
authors.forename: Olufunmilayo Olaide
authors.initials: OO
authors.lastname: Adeyemi
authors.forename: Adejuwon Adewale
authors.initials: AA
authors.lastname: Adeneye
authors.forename: Tope Elizabeth
authors.initials: TE
authors.lastname: Alabi
mesh_terms: D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D029062:Apocynaceae / Q000737:chemistry*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D016488:Medicine, African Traditional; D051379:Mice; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D000700:Analgesics; D010936:Plant Extracts; D014867:Water