title: Potassium-encapsulated arsenic-dithiolato compounds: synthesis, structural calculation, and biological relevance.
abstract: This study based on the synthesis, characterization, and structural calculation of small molecular potassium-encapsulated arsenic-dithiolato compounds will provide fundamental knowledge about arsenic metabolism behavior in biological system. Two novel air-stable potassium-encapsulated arsenic-dithiolato compounds, [K@As(2)(L1)(3)](BF(4)) (1) and [K@As(2)(L2)(3)](BF(4)) (2), were prepared using deprotonated 2,6-bis(mercaptomethyl)pyridine (L1H(2)) and 1,3-dimercapto-m-xylene (L2H(2)) to react with AsCl(3) in the presence of potassium cation. Compounds 1 and 2 have been characterized by electrospray ionization-mass spectra, nuclear magnetic resonance spectra, and elemental microanalysis. Density functional theory calculation also supports the formation and binding properties of the potassium-encapsulated arsenic-dithiolato compounds.
authors.affiliation: Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan. sodiohsu@kmu.edu.tw
authors.forename: Sodio C N
authors.initials: SC
authors.lastname: Hsu
authors.forename: Troy T Y
authors.initials: TT
authors.lastname: Lin
authors.forename: Hsing-Yin
authors.initials: HY
authors.lastname: Chen
authors.forename: Shih-Wei
authors.initials: SW
authors.lastname: Chuo
authors.forename: Chai-Lin
authors.initials: CL
authors.lastname: Kao
authors.forename: Po-Yu
authors.initials: PY
authors.lastname: Chen
authors.forename: Min-Yuan
authors.initials: MY
authors.lastname: Hung
mesh_terms: D001152:Arsenicals / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D011188:Potassium / Q000737:chemistry*; D017680:Potassium Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D001152:Arsenicals; D009942:Organometallic Compounds; D017680:Potassium Compounds; D011188:Potassium