title: A new ferulic acid ester, a new ellagic acid derivative, and other constituents from pachycentria formosana: effects on neutrophil pro-inflammatory responses.
abstract: A new ferulic acid ester derivative, tetracosane-1,24-diyl di[(Z)-ferulate] (1), and a new ellagic acid derivative, 3,4 : 3',4'-bis(O,O-methylene)ellagic acid (2), have been isolated from leaves and twigs of Pachycentria formosana, together with eight known compounds. Their structures were determined by in-depth spectroscopic and mass-spectrometric analyses. Among the isolated compounds, oleanolic acid (6), ursolic acid acetate (7), and 3-epibetulinic acid (9) exhibited potent inhibition (IC(50) values ≤ 21.8 μM) of O₂(-) generation by human neutrophils in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). In addition, oleanolic acid (6), 3-O-[(E)-feruloyl]ursolic acid (8), 3-epibetulinic acid (9), and lawsonic acid (10) also inhibited fMLP/CB-induced elastase release with IC(50) values ≤ 18.6 μM.
authors.affiliation: School of Pharmacy, Taipei Medical University, Taipei 110, Taiwan.
authors.forename: Jui-Ying
authors.initials: JY
authors.lastname: Cho
authors.forename: Tzong-Huei
authors.initials: TH
authors.lastname: Lee
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.forename: Sheng-Zehn
authors.initials: SZ
authors.lastname: Yang
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
authors.forename: Tsung-Hsien
authors.initials: TH
authors.lastname: Chou
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
authors.forename: Jih-Jung
authors.initials: JJ
authors.lastname: Chen
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D003373:Coumaric Acids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004610:Ellagic Acid / Q000031:analogs & derivatives / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004952:Esters; D006801:Humans; D035322:Melastomataceae / Q000737:chemistry*; D009504:Neutrophils / Q000187:drug effects*; D010196:Pancreatic Elastase / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism
chemical_list: C569158:3,4:3',4'-bis(O,O-methylene)ellagic acid; D000893:Anti-Inflammatory Agents; D003373:Coumaric Acids; D004952:Esters; C569157:tetracosane-1,24-diyl di((Z)-ferulate); D013481:Superoxides; D004610:Ellagic Acid; C004999:ferulic acid; D010196:Pancreatic Elastase