title: Myosin motor proteins are involved in the final stages of the secretory pathways.
abstract: In eukaryotes, the final steps in both the regulated and constitutive secretory pathways can be divided into four distinct stages: (i) the 'approach' of secretory vesicles/granules to the PM (plasma membrane), (ii) the 'docking' of these vesicles/granules at the membrane itself, (iii) the 'priming' of the secretory vesicles/granules for the fusion process, and, finally, (iv) the 'fusion' of vesicular/granular membranes with the PM to permit content release from the cell. Recent work indicates that non-muscle myosin II and the unconventional myosin motor proteins in classes 1c/1e, Va and VI are specifically involved in these final stages of secretion. In the present review, we examine the roles of these myosins in these stages of the secretory pathway and the implications of their roles for an enhanced understanding of secretion in general.
authors.affiliation: Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, UK.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Bond
authors.forename: Hemma
authors.initials: H
authors.lastname: Brandstaetter
authors.forename: James R
authors.initials: JR
authors.lastname: Sellers
authors.forename: John
authors.initials: J
authors.lastname: Kendrick-Jones
authors.forename: Folma
authors.initials: F
authors.lastname: Buss
mesh_terms: D002462:Cell Membrane / Q000378:metabolism; D005089:Exocytosis / Q000502:physiology*; D006801:Humans; D008561:Membrane Fusion / Q000502:physiology; D020409:Molecular Motor Proteins / Q000378:metabolism*; D009218:Myosins / Q000145:classification / Q000378:metabolism*; D024507:Nonmuscle Myosin Type IIA / Q000378:metabolism; D020033:Protein Isoforms / Q000145:classification / Q000378:metabolism*; D055571:Secretory Pathway / Q000502:physiology*; D022142:Secretory Vesicles / Q000378:metabolism
chemical_list: D020409:Molecular Motor Proteins; D020033:Protein Isoforms; D024507:Nonmuscle Myosin Type IIA; D009218:Myosins