title: Site-based research in acute heart failure.
abstract: The conduct of clinical trials in acute heart failure has arrived at a critical point. Traditional systems used to conduct clinical trials have been described as inefficient, lacking infrastructure, and enormously expensive. In this article, the authors describe an alternative model: the development of a site-based research (SBR) unit, an operating business unit responsible for conducting a portfolio of research projects in a therapeutic area. The SBR is responsible for financial accountability, regulatory compliance, and academic productivity.
authors.affiliation: Duke University, Durham, NC 27710, USA. patricia.adams@duke.edu
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Adams
mesh_terms: D000208:Acute Disease; D002986:Clinical Trials as Topic; D006333:Heart Failure / Q000628:therapy*; D006805:Human Experimentation / Q000592:standards*; D006801:Humans; D017063:Outcome Assessment, Health Care; D014481:United States