title: Making sense of glycosphingolipids in epithelial polarity.
abstract: A potential role for glycosphingolipids and lipid rafts in apical sorting was initially met with enthusiasm, but genetic analysis has since provided little support for it. A report now establishes that glycosphingolipids mediate apical sorting, and specifically help maintain apicobasal polarity in Caenorhabditis elegans.
authors.affiliation: IGBMC, Development and Stem Cells Program, CNRS (UMR7104), INSERM (U964), Université de Strasbourg, 1 rue Laurent Fries, BP10142, 67400 Illkirch, France. hyenne@igbmc.fr
authors.forename: Vincent
authors.initials: V
authors.lastname: Hyenne
authors.forename: Michel
authors.initials: M
authors.lastname: Labouesse
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D016764:Cell Polarity; D004847:Epithelial Cells / Q000378:metabolism*; D006028:Glycosphingolipids / Q000096:biosynthesis*; D007413:Intestinal Mucosa / Q000378:metabolism*
chemical_list: D006028:Glycosphingolipids