title: Bedside optical imaging of occipital resting-state functional connectivity in neonates.
abstract: Resting-state networks derived from temporal correlations of spontaneous hemodynamic fluctuations have been extensively used to elucidate the functional organization of the brain in adults and infants. We have previously developed functional connectivity diffuse optical tomography methods in adults, and we now apply these techniques to study functional connectivity in newborn infants at the bedside. We present functional connectivity maps in the occipital cortices obtained from healthy term-born infants and premature infants, including one infant with an occipital stroke. Our results suggest that functional connectivity diffuse optical tomography has potential as a valuable clinical tool for the early detection of functional deficits and for providing prognostic information on future development.
authors.affiliation: Department of Physics, Washington University, One Brookings Drive, St. Louis, MO 63130, USA.
authors.forename: Brian R
authors.initials: BR
authors.lastname: White
authors.forename: Steve M
authors.initials: SM
authors.lastname: Liao
authors.forename: Silvina L
authors.initials: SL
authors.lastname: Ferradal
authors.forename: Terrie E
authors.initials: TE
authors.lastname: Inder
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Culver
mesh_terms: D001930:Brain Injuries / Q000473:pathology; D001931:Brain Mapping; D002560:Cerebrovascular Circulation / Q000502:physiology; D003627:Data Interpretation, Statistical; D003952:Diagnostic Imaging / Q000379:methods*; D004569:Electroencephalography; D005240:Feasibility Studies; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D008953:Models, Anatomic; D009434:Neural Pathways / Q000033:anatomy & histology / Q000473:pathology / Q000502:physiology*; D009778:Occipital Lobe / Q000033:anatomy & histology / Q000473:pathology / Q000502:physiology*; D010865:Pilot Projects; D019095:Point-of-Care Systems; D011379:Prognosis; D020521:Stroke / Q000473:pathology; D014054:Tomography / Q000379:methods; D014793:Visual Cortex / Q000033:anatomy & histology / Q000502:physiology