title: Nickel-catalyzed Negishi cross-couplings of 6-chloropurines with organozinc halides at room temperature.
abstract: An efficient method for the synthesis of 6-alkyl or 6-aryl purines (nucleosides) was developed via nickel-catalyzed Negishi cross-couplings of 6-chloropurines and organozinc halides. The ligand-free process gave good to excellent isolated yields at room temperature.
authors.affiliation: College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University, Xinxiang, 453007, China.
authors.forename: Dong-Chao
authors.initials: DC
authors.lastname: Wang
authors.forename: Hong-Ying
authors.initials: HY
authors.lastname: Niu
authors.forename: Gui-Rong
authors.initials: GR
authors.lastname: Qu
authors.forename: Lei
authors.initials: L
authors.lastname: Liang
authors.forename: Xue-Jiao
authors.initials: XJ
authors.lastname: Wei
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Hai-Ming
authors.initials: HM
authors.lastname: Guo
mesh_terms: D001372:Aza Compounds / Q000737:chemistry; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D006219:Halogens / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry; D009942:Organometallic Compounds / Q000032:analysis / Q000138:chemical synthesis*; D011687:Purines / Q000737:chemistry*; D013696:Temperature; D015032:Zinc / Q000737:chemistry*
chemical_list: D001372:Aza Compounds; D006219:Halogens; D009942:Organometallic Compounds; D011687:Purines; D009532:Nickel; D015032:Zinc; C079308:6-chloropurine