title: A comparison between the effectiveness of erythromycin, single-dose clarithromycin and topical fusidic acid in the treatment of erythrasma.
abstract: Although erythrasma is a superficial skin infection, there is no consensus on the treatment model of erythrasma.
  
  
  OBJECTIVE
  To compare the efficacy of erythromycin, single-dose clarithromycin and topical fusidic acid in the treatment of erythrasma in a double-blind, placebo-controlled, randomized trial.
  
  
  METHODS
  Hundred and fifty-one patients over 18 years of age were included in this study. Patients were randomized and divided into five groups. They received clarithromycin, erythromycin, fusidic acid cream, placebo cream or placebo tablets. Patients were evaluated by Wood's light reflection scores and the initial score values and the values on the days of 2, 7 and 14 were compared statistically.
  
  
  RESULTS
  According to the mean of Wood's light reflection scores, the efficacy of fusidic acid cream therapy was significantly higher than other therapies. When the efficacy of clarithromycin and erythromycin therapy was compared, clarithromycin therapy was significantly more effective than erythromycin therapy at 48 h. However, there was no statistical difference on the days of 7 and 14.
  
  
  CONCLUSIONS
  Topical fusidic acid proved to be the most effective treatment; however, clarithromycin therapy may be an alternative regimen in the treatment of erythrasma because of its efficiency and better patient's compliance.
authors.affiliation: Department of Dermatology, Dokuz Eylül University Faculty of Medicine, Izmir, Turkey.
authors.forename: Oktay
authors.initials: O
authors.lastname: Avci
authors.forename: Taner
authors.initials: T
authors.lastname: Tanyildizi
authors.forename: Ergun
authors.initials: E
authors.lastname: Kusku
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017291:Clarithromycin / Q000627:therapeutic use*; D004311:Double-Blind Method; D004894:Erythrasma / Q000188:drug therapy*; D004917:Erythromycin / Q000627:therapeutic use*; D005260:Female; D005672:Fusidic Acid / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D063465:Skin Cream; D017192:Skin Diseases, Bacterial / Q000188:drug therapy*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D005672:Fusidic Acid; D004917:Erythromycin; D017291:Clarithromycin