title: Association of tag SNPs of GPx-3 with essential hypertension in rural Han Chinese in Fuxin, Liaoning, China.
abstract: BACKGROUND
  Genetic mechanisms contribute to blood pressure regulation. This study investigated whether glutathione peroxidase (GPx-3) tag single nucleotide polymorphisms (SNPs) are associated with hypertension in the rural areas of Fuxin county, Liaoning province, China.
  
  
  METHODS
  Indigenous Fuxin Han people participated, 523 unrelated hypertensives and 547 controls were recruited. All tag SNPs of GPx-3 gene were selected. We estimated SNP allele frequency in DNA pools with pyrosequencing.
  
  
  RESULTS
  Before Bonferroni correction, C allele frequency for rs8177417 was significantly higher in hypertensives than those in controls (23.4% vs. 19.3%, P = 0.014); T allele frequency for rs3828599 was significantly lower in hypertensives than those in controls (35.6% vs. 40.8%, P = 0.009). However, when a Bonferroni correction for multiple testing was applied, only the polymorphisms rs3828599 of GPx-3 gene was associated with hypertension (P = 0.045, OR: 0.833, 95%CI: 0.695 - 0.998).
  
  
  CONCLUSIONS
  The polymorphism of rs3828599 of GPx-3 gene might be associated with hypertension in rural Han Chinese from Fuxin, Liaoning.
authors.affiliation: Department of Cardiology, First Hospital of China Medical University, Shenyang, Liaoning 110001, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Hao
authors.forename: Bao-gang
authors.initials: BG
authors.lastname: Wu
authors.forename: Jin
authors.initials: J
authors.lastname: Shi
authors.forename: Yan-li
authors.initials: YL
authors.lastname: Chen
authors.forename: Zhao-qing
authors.initials: ZQ
authors.lastname: Sun
authors.forename: Li-qiang
authors.initials: LQ
authors.lastname: Zheng
authors.forename: Xin-gang
authors.initials: XG
authors.lastname: Zhang
authors.forename: Ning
authors.initials: N
authors.lastname: Geng
authors.forename: Tie-jun
authors.initials: TJ
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.forename: Ying-xian
authors.initials: YX
authors.lastname: Sun
mesh_terms: D000368:Aged; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005979:Glutathione Peroxidase / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: C486484:GPX3 protein, human; D005979:Glutathione Peroxidase