title: The synchronization of spontaneous BOLD activity predicts extraversion and neuroticism.
abstract: There is an increasing body of evidence pointing to a relationship between personality and brain markers. The purpose of this study was to identify the associations between personality dimensions of extraversion and neuroticism and the local synchronization of spontaneous blood oxygen level-dependent (BOLD) activity assessed by regional homogeneity (ReHo) approach. Our results revealed the significant negative correlation between neuroticism and ReHo in the left middle frontal gyrus, providing evidence for the left frontal activation involved in pleasant emotion. ReHo was correlated negatively with extraversion in the medial prefrontal cortex (MPFC), an important portion of the default mode network (DMN), thus further indicating the relationship between DMN and personality. In addition, ReHo in the insula, cerebellum and cingulate gyrus was correlated positively with extraversion, suggesting the associations between individual difference in extraversion and specific brain regions involved in affective processing. These findings shed light on the important relationship between the synchronization of spontaneous fluctuations and personality dimensions of extraversion and neuroticism, which provide further evidence for the neural underpinning of individual difference in personality traits.
authors.affiliation: Key laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, PR China.
authors.forename: Luqing
authors.initials: L
authors.lastname: Wei
authors.forename: Xujun
authors.initials: X
authors.lastname: Duan
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Wei
authors.initials: W
authors.lastname: Liao
authors.forename: Qing
authors.initials: Q
authors.lastname: Gao
authors.forename: Ju-rong
authors.initials: JR
authors.lastname: Ding
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Zhang
authors.forename: Weixi
authors.initials: W
authors.lastname: Zeng
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.forename: Guangming
authors.initials: G
authors.lastname: Lu
authors.forename: Huafu
authors.initials: H
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods; D005120:Extraversion, Psychological; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009497:Neurotic Disorders / Q000175:diagnosis / Q000503:physiopathology*; D010100:Oxygen / Q000097:blood*; D010551:Personality / Q000502:physiology*; D011237:Predictive Value of Tests; D055815:Young Adult
chemical_list: D010100:Oxygen