title: Exercise increases insulin content and basal secretion in pancreatic islets in type 1 diabetic mice.
abstract: Exercise appears to improve glycemic control for people with type 1 diabetes (T1D). However, the mechanism responsible for this improvement is unknown. We hypothesized that exercise has a direct effect on the insulin-producing islets. Eight-week-old mice were divided into four groups: sedentary diabetic, exercised diabetic, sedentary control, and exercised control. The exercised groups participated in voluntary wheel running for 6 weeks. When compared to the control groups, the islet density, islet diameter, and β-cell proportion per islet were significantly lower in both sedentary and exercised diabetic groups and these alterations were not improved with exercise. The total insulin content and insulin secretion were significantly lower in sedentary diabetics compared to controls. Exercise significantly improved insulin content and insulin secretion in islets in basal conditions. Thus, some improvements in exercise-induced glycemic control in T1D mice may be due to enhancement of insulin content and secretion in islets.
authors.affiliation: Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Kansas City, KS 66160, USA.
authors.forename: Han-Hung
authors.initials: HH
authors.lastname: Huang
authors.forename: Kevin
authors.initials: K
authors.lastname: Farmer
authors.forename: Jill
authors.initials: J
authors.lastname: Windscheffel
authors.forename: Katie
authors.initials: K
authors.lastname: Yost
authors.forename: Mary
authors.initials: M
authors.lastname: Power
authors.forename: Douglas E
authors.initials: DE
authors.lastname: Wright
authors.forename: Lisa
authors.initials: L
authors.lastname: Stehno-Bittel
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000473:pathology; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000166:cytology*; D008297:Male; D051379:Mice; D008856:Microscopy, Fluorescence / Q000379:methods; D010179:Pancreas / Q000473:pathology; D010805:Physical Conditioning, Animal; D012420:Running; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin