title: Lipid risk factors among elderly with normal fasting glucose, impaired fasting glucose and type 2 diabetes mellitus. The Italian longitudinal study on aging.
abstract: OBJECTIVE
  Three groups of subjects were identified within a representative sample of older Italians: subjects with normal fasting glucose (NFG), with impaired fasting glucose (IFG) or with type 2 diabetes mellitus (T2D). The aim of the present study was to evaluate the relationship among plasma lipids, lipoproteins, other metabolic factors in the three groups, and their role in predicting total fatal events.
  
  
  RESULTS
  2422 subjects, aged 65-84 years, taking part into the Italian Longitudinal Study on Aging were included in the analyses. Factor analysis was conducted separately for men and women. Factor scores were used as independent variables in Cox Proportional Hazard models, to determine factors predicting death at the follow-up in NFG, IFG and T2D subjects. Four major factors were found for men ("insulin resistance", "body size", "total cholesterol", "HDL cholesterol") and four also for women ("insulin resistance", "total cholesterol", "body size", "HDL cholesterol"). For NFG and IFG men, and for both T2D men and women, the "HDL cholesterol" was a significant protective factor for total deaths (NFG men: HR = 0.79, 95% CI 0.67-0.93; IFG men: HR = 0.59, 95% CI 0.45-0.79; T2D men: HR = 0.55, 95% CI 0.34-0.89; T2D women: HR = 0.61, 95% CI 0.44-0.86). Among NFG women, the "body size" factor was also a protective factor with respect to total deaths (HR = 0.74, 95% CI 0.57-0.95).
  
  
  CONCLUSIONS
  A factor including HDL Cholesterol and Apo A-I showed protection against all-cause mortality in older men, independently from the glycemia level, and in women only in those diagnosed with T2D.
authors.affiliation: CNR-Institute of Neuroscience, Padova, Via Giustiniani, 2, 35128 Padova, Italy. marianna.noale@in.cnr.it
authors.forename: M
authors.initials: M
authors.lastname: Noale
authors.forename: S
authors.initials: S
authors.lastname: Maggi
authors.forename: S
authors.initials: S
authors.lastname: Zanoni
authors.forename: F
authors.initials: F
authors.lastname: Limongi
authors.forename: S
authors.initials: S
authors.lastname: Zambon
authors.forename: G
authors.initials: G
authors.lastname: Crepaldi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000886:Anthropometry; D016632:Apolipoprotein A-I / Q000097:blood; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D005163:Factor Analysis, Statistical; D005215:Fasting; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D007558:Italy; D008137:Longitudinal Studies; D008297:Male; D011236:Prediabetic State / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D012307:Risk Factors
chemical_list: D016632:Apolipoprotein A-I; D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL