title: Effects of loops and nucleotides in G-quadruplexes on their interaction with an azacalixarene, methylazacalix[6]pyridine.
abstract: A novel trend in G-quadruplex ligand design is to build a binder that is able to not only discriminate G-quadruplex from duplex-DNA, but also among various G-quadruplex structures. Methylazacalix[6]pyridine (MACP6), a new type of azacalixarene with flexible conformation, exhibits induced circular dichroism signals when interacted with most of G-quadruplexes. The intensities of the induced signals are strongly dependent on the topology of G-quadruplexes. Further evidence has shown that these signals can be ascribed to the preferred binding of MACP6 to the loops of G-quadruplexes, which rely on the nature of nucleotides in the loops.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Center for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Chinese Academy of Sciences, Beijing, P R China.
authors.forename: Ai-Jiao
authors.initials: AJ
authors.lastname: Guan
authors.forename: En-Xuan
authors.initials: EX
authors.lastname: Zhang
authors.forename: Jun-Feng
authors.initials: JF
authors.lastname: Xiang
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.forename: Qian-Fan
authors.initials: QF
authors.lastname: Yang
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.forename: Ya-Lin
authors.initials: YL
authors.lastname: Tang
authors.forename: Mei-Xiang
authors.initials: MX
authors.lastname: Wang
mesh_terms: D001483:Base Sequence; D047250:Calixarenes / Q000737:chemistry*; D002942:Circular Dichroism; D054856:G-Quadruplexes; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009711:Nucleotides / Q000737:chemistry*
chemical_list: D009711:Nucleotides; C570637:methylazacalix(6)pyridine; D047250:Calixarenes