title: Management of metastatic ovarian Sertoli-Leydig cell tumor with sporadic multinodular goiter: a case report and literature review.
abstract: Information regarding treatment for patients with metastatic ovarian Sertoli-Leydig cell tumor (SLCT) has been extremely limited. We report a young woman whose stage IA, poorly differentiated SLCT was initially managed surgically 9 months earlier, and who presented with extensively metastatic SLCT. She had a dramatic response to the combination of bleomycin, etoposide and cisplatin followed by stem cell transplantation and surgery, and has shown no evidence of disease recurrence for 8 months postoperatively. The patient was also found to have sporadic non-toxic multinodular goiter, which has not changed over the treatment course as mentioned. A review of the literature concerning the management of metastatic ovarian SLCT, along with its coexistence with multinodular goiter, is presented.
authors.affiliation: Department of Medicine, Saint Joseph Hospital/University of Illinois at Chicago, 60657, USA. chimingtea@ gmail.com
authors.forename: Ming
authors.initials: M
authors.lastname: Chi
authors.forename: Alan D
authors.initials: AD
authors.lastname: Gilman
authors.forename: Nkem
authors.initials: N
authors.lastname: Iroegbu
mesh_terms: D000328:Adult; D005260:Female; D006044:Goiter, Nodular / Q000150:complications*; D006801:Humans; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D012008:Recurrence; D018310:Sertoli-Leydig Cell Tumor / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome