title: Effect of fluoxetine on some cognitive functions of patients of depression.
abstract: BACKGROUND
  This study was carried out to evaluate the effect of long-term administration of a commonly prescribed antidepressant, fluoxetine from different group on memory and psychomotor functions in patients of various psychiatric disorders using a battery of simple tests that can be conveniently applied to the Indian population.
  
  
  METHODS
  Memory was evaluated using the PGI memory scale and psychomotor functions were evaluated using six letter cancellation test. Statistical analysis was carried out using Wilcoxon signed-rank test.
  
  
  CONCLUSIONS
  The results of the study reveal that there was significant improvement in some cognitive function. Cognitive functions are improved at first follow-up and they improved continuously up to last follow-up that is at one month. It is observed that there was improvement in the primary disease. So, final score of the cognitive parameters is because of the resultant activity of direct drug action and improvement in the underlying disease.
authors.affiliation: Departmet of Pharmacology, New Civil Hospital, Government Medical College, Majura Gate, Surat-395 001, India.
authors.lastname: Jaykaran
authors.forename: Pankaj
authors.initials: P
authors.lastname: Bhardwaj
authors.forename: N D
authors.initials: ND
authors.lastname: Kantharia
authors.forename: Preeti
authors.initials: P
authors.lastname: Yadav
authors.forename: Arvind
authors.initials: A
authors.lastname: Panwar