title: The promise and limitations of population exomics for human evolution studies.
abstract: Exome sequencing is poised to yield substantial insights into human genetic variation and evolutionary history, but there are significant challenges to overcome before this becomes a reality.
authors.affiliation: Department of Genome Sciences, University of Washington, 3720 15th Ave NE, Box 355065, Seattle, WA 98195-5065, USA.
authors.forename: Jacob A
authors.initials: JA
authors.lastname: Tennessen
authors.forename: Timothy D
authors.initials: TD
authors.lastname: O'Connor
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Bamshad
authors.forename: Joshua M
authors.initials: JM
authors.lastname: Akey
mesh_terms: D003710:Demography; D019143:Evolution, Molecular; D059472:Exome; D014644:Genetic Variation; D005828:Genetics, Population; D015894:Genome, Human; D023281:Genomics / Q000379:methods*; D006801:Humans; D012641:Selection, Genetic; D017422:Sequence Analysis, DNA