title: Antioxidant and lipid peroxidation activities in rats fed with Aspergillus carbonarius carotenoid.
abstract: Effect of feeding partially saturated canthaxanthin (PSC), purified from Aspergillus carbonarius mutant, was studied using four groups of female albino rats (n=6) for 4 weeks. While the control group received basal diet ad libitum, Groups I, II and III were fed with basal diet containing 50, 100 and 250 ppm PSC, respectively. PSC feeding did not cause any significant changes in food intake and there was no gain in body weight either. PSC included in the diet significantly decreased cholesterol in blood. There was 44.75% and 60.54% decrease in LDL-cholesterol in rats fed with 50 and 100 ppm carotenoid. Hepatic ascorbic acid content increased by 44.59% in rats fed with 50 ppm PSC. Dietary PSC at 250 ppm lowered lipid peroxides by 19.49%. Activities of antioxidant enzymes, glutathione transferase and catalase were significantly higher in serum and liver of PSC fed rats compared to the controls. The results suggested that PSC feeding can induce hypocholesterolmic and antioxidant properties in rats.
authors.affiliation: Department of Food Microbiology, Central Food Technological Research Institute (Council of Scientific and Industrial Research), Mysore 570020, India.
authors.forename: Anbarasu
authors.initials: A
authors.lastname: Kumar
authors.forename: Akshatha Hosahalli
authors.initials: AH
authors.lastname: Srikanta
authors.forename: S P
authors.initials: SP
authors.lastname: Muthukumar
authors.forename: Umesh-Kumar
authors.initials: UK
authors.lastname: Sukumaran
authors.forename: Vijayalakshmi
authors.initials: V
authors.lastname: Govindaswamy
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000008:administration & dosage* / Q000378:metabolism; D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000032:analysis; D001230:Aspergillus / Q000737:chemistry*; D001835:Body Weight / Q000187:drug effects; D016644:Canthaxanthin / Q000008:administration & dosage* / Q000096:biosynthesis; D002374:Catalase / Q000378:metabolism; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005982:Glutathione Transferase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008054:Lipid Peroxides / Q000032:analysis; D008099:Liver / Q000737:chemistry / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000924:Anticholesteremic Agents; D000975:Antioxidants; D008078:Cholesterol, LDL; D008054:Lipid Peroxides; D016644:Canthaxanthin; D002374:Catalase; D005982:Glutathione Transferase; D001205:Ascorbic Acid