title: [Interleukin 8 and interferon gamma in ocular toxoplasmosis].
abstract: Toxoplasmosis is one of the most common parasitic infections in the world, it is caused by Toxoplasma gondii. The infection is typically asymptomatic or the symptoms are very mild. Approximately 10% patients have limphadenopathy, involvement of the others organs, like eyes, nervous system, liver, heart, are observed more rarely.
  
  
  OBJECTIVE
  The aim of our study was to assess the level of selected cytokines in blood among patients with ocular toxoplasmosis.
  
  
  METHODS
  We have enrolled in the study 30 patients, 19-42 years old, treated for ocular toxoplasmosis, and 20 healthy volunteers, 20-48 years old, to the control group. Tests for blood morphology, C-reactive protein, the level of IL-8 and IFN-gamma were performed in all patients. The blood parameters in toxoplasmosis group were performed before antiparasitic treatment was given.
  
  
  RESULTS
  The level of IFN-gamma in blood was lower among patients with ocular toxoplasmosis comparing with control group (1.52 vs. 4.18 pg/ml; p = 0.002). The level of IL-8 in blood was lower among patients with ocular toxoplasmosis comparing with control group (22.96 vs. 94.3 pg/ml; p = 0,007). There were no correlations between analyzed cytokines and blood morphology or CRP.
  
  
  CONCLUSIONS
  The low level of IFN-gamma and IL-8 in blood is important factor leading to reactivation of the ocular toxoplasmosis.
authors.affiliation: Z Kliniki Chorób Zakaźnych Katedry Gastroenterologii, Hepatologii i Chorób Zakaźnych Uniwersytetu Jagiellońskiego Collegium Medicum w Krakowie.
authors.forename: Jacek
authors.initials: J
authors.lastname: Czepiel
authors.forename: Grazyna
authors.initials: G
authors.lastname: Biesiada
authors.forename: Iwona
authors.initials: I
authors.lastname: Sobczyk-Krupiarz
authors.forename: Grazyna
authors.initials: G
authors.lastname: Miklasszewska
authors.forename: Danuta
authors.initials: D
authors.lastname: Fedak
authors.forename: Bogdan
authors.initials: B
authors.lastname: Solnica
authors.forename: Tomasz
authors.initials: T
authors.lastname: Mach
authors.forename: Aleksander
authors.initials: A
authors.lastname: Garlicki
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D014122:Toxoplasma / Q000276:immunology*; D014126:Toxoplasmosis, Ocular / Q000097:blood* / Q000276:immunology* / Q000469:parasitology; D055815:Young Adult
chemical_list: D015415:Biomarkers; D016209:Interleukin-8; D007371:Interferon-gamma; D002097:C-Reactive Protein