title: Predicting psychopharmacological drug effects on actual driving performance (SDLP) from psychometric tests measuring driving-related skills.
abstract: BACKGROUND
  There are various methods to examine driving ability. Comparisons between these methods and their relationship with actual on-road driving is often not determined.
  
  
  OBJECTIVE
  The objective of this study was to determine whether laboratory tests measuring driving-related skills could adequately predict on-the-road driving performance during normal traffic.
  
  
  METHODS
  Ninety-six healthy volunteers performed a standardized on-the-road driving test. Subjects were instructed to drive with a constant speed and steady lateral position within the right traffic lane. Standard deviation of lateral position (SDLP), i.e., the weaving of the car, was determined. The subjects also performed a psychometric test battery including the DSST, Sternberg memory scanning test, a tracking test, and a divided attention test. Difference scores from placebo for parameters of the psychometric tests and SDLP were computed and correlated with each other. A stepwise linear regression analysis determined the predictive validity of the laboratory test battery to SDLP.
  
  
  RESULTS
  Stepwise regression analyses revealed that the combination of five parameters, hard tracking, tracking and reaction time of the divided attention test, and reaction time and percentage of errors of the Sternberg memory scanning test, together had a predictive validity of 33.4%.
  
  
  CONCLUSIONS
  The psychometric tests in this test battery showed insufficient predictive validity to replace the on-the-road driving test during normal traffic.
authors.affiliation: Utrecht Institute for Pharmaceutical Sciences, Division of Pharmacology, Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht, The Netherlands. j.c.verster@uu.nl
authors.forename: Joris C
authors.initials: JC
authors.lastname: Verster
authors.forename: Thomas
authors.initials: T
authors.lastname: Roth
mesh_terms: D000328:Adult; D001288:Attention / Q000187:drug effects; D001334:Automobile Driving / Q000523:psychology* / Q000706:statistics & numerical data; D002986:Clinical Trials as Topic; D018849:Controlled Clinical Trials as Topic / Q000523:psychology / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects; D008960:Models, Psychological; D011237:Predictive Value of Tests; D011594:Psychometrics / Q000295:instrumentation / Q000706:statistics & numerical data*; D011597:Psychomotor Performance / Q000187:drug effects*; D011619:Psychotropic Drugs / Q000494:pharmacology*; D015203:Reproducibility of Results
chemical_list: D011619:Psychotropic Drugs