title: A new chromene isolated from Ageratum conyzoides.
abstract: From the ethanol extract of the whole plant of Ageratum conyzoides L. (Compositae), one new chromene, 2,2-dimethylchromene 7-methoxy-6-O-beta-D-glucopyranoside, was isolated, together with thirteen known compounds, seven of which were being reported for the first time. The compounds were all characterized by MS, IR, 1D- and 2D-NMR spectroscopy. 7,3',5'-Tri-O-methyltricetin (7), precocene II (9), 3,5,7,4'-tetrahydroxyflavone (13) and 5,6,7,3',4',5'-hexamethoxyflavone (14) exhibited inhibitory activity on the P-388 cancer cell line with IC50 values of 12.8, 24.8, 3.5 and 7.8 microM respectively, while compound 9 exhibited inhibitory activity on the HT-29 cancer cell line with an IC50 value of 61 microM; the others showed no significant cytotoxic activity on the cell lines tested.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China. biodunbayo@yahoo.com
authors.forename: Abiodun Humphrey
authors.initials: AH
authors.lastname: Adebayo
authors.forename: Chang-Jiu
authors.initials: CJ
authors.lastname: Jig
authors.forename: Yu-Mei
authors.initials: YM
authors.lastname: Zhang
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: He
authors.forename: Guang-Zhi
authors.initials: GZ
authors.lastname: Zeng
authors.forename: Hong-Jin
authors.initials: HJ
authors.lastname: Han
authors.forename: Jun-Ju
authors.initials: JJ
authors.lastname: Xu
authors.forename: Afolabi Akintunde
authors.initials: AA
authors.lastname: Akindahunsi
authors.forename: Ning-Hua
authors.initials: NH
authors.lastname: Tana
mesh_terms: D031163:Ageratum / Q000737:chemistry*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D001578:Benzopyrans / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001578:Benzopyrans