title: The role of chemokines, cytokines and adhesion molecules in stem cell trafficking and homing.
abstract: Although definition and mechanistic understanding of pro-angiogenic progenitor cells remains unsatisfactory, general agreement highlights their role in regenerative process following tissue injury and ischemia. Furthermore, stem-cell based therapy represents a hot topic of cardiovascular medicine. Recent studies provide new insights on the signalling pathways that modulate stem/progenitor cell mobilization from bone marrow, homing to ischemic area and participation in vascular remodelling and tissue healing. This review focuses on current knowledge and emerging concepts on stem cell/progenitor cell trafficking in relation to changes in surrounding environment and epigenetic modifications caused by risk factors and comorbidities.
authors.affiliation: Chair of Experimental Cardiovascular Medicine, University of Bristol, Bristol Royal Infirmary, Bristol BS2 8HW, United Kingdom.
authors.forename: Y
authors.initials: Y
authors.lastname: Cui
authors.forename: P
authors.initials: P
authors.lastname: Madeddu
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000628:therapy; D015815:Cell Adhesion Molecules / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D018925:Chemokines / Q000276:immunology / Q000378:metabolism / Q000502:physiology; D016207:Cytokines / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism; D006801:Humans; D018919:Neovascularization, Physiologic / Q000235:genetics; D015398:Signal Transduction; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology* / Q000276:immunology / Q000378:metabolism
chemical_list: D015815:Cell Adhesion Molecules; D018925:Chemokines; D016207:Cytokines