title: Association analysis between the tag SNP for sonic hedgehog rs9333613 polymorphism and male sexual orientation.
abstract: Male sexual orientation has been proposed to have genetic components, but  previously suggested candidate genes have all received negative results. The  human sonic hedgehog (SHH) gene is located in the 7q36 region, which  was linked to male sexual orientation in a previous genome-wide association  study. SHH is known to play an important role in embryo patterning,  and there is evidence connecting it to sexual orientation. In this study, we  performed an association analysis of the SHH tag single nucleotide  polymorphism rs9333613 in 361 subjects and 319 Chinese male controls. We find  a significant difference in genotype and allele distribution between  identified homosexuals and heterosexual control subjects, suggesting that the  SHH gene could potentially be associated with male sexual  orientation.
authors.affiliation: Shenzhen Center for Chronic Disease Control and Prevention, Shenzhen, China.
authors.forename: Binbin
authors.initials: B
authors.lastname: Wang
authors.forename: Sirui
authors.initials: S
authors.lastname: Zhou
authors.forename: Fuchang
authors.initials: F
authors.lastname: Hong
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Liu
authors.forename: Yumao
authors.initials: Y
authors.lastname: Cai
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.forename: Tiejian
authors.initials: T
authors.lastname: Feng
authors.forename: Xu
authors.initials: X
authors.lastname: Ma
mesh_terms: D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005787:Gene Frequency; D005838:Genotype; D053823:Hedgehog Proteins / Q000235:genetics*; D020010:Heterosexuality; D018451:Homosexuality, Male / Q000235:genetics*; D006801:Humans; D008297:Male; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide
chemical_list: D053823:Hedgehog Proteins; C509239:SHH protein, human