title: Micelles catalyzed chemoselective synthesis 'in water' and biological evaluation of oxygen containing hetero-1,4-naphthoquinones as potential antifungal agents.
abstract: Various oxygen containing 1,4-naphthoquinone derivatives have been synthesized chemoselectively by an economical, viable green methodology approach using water as solvent with or without surfactants such as Triton X-100, SDS, LD (laundry detergent), and TBAB, a phase transfer catalyst and evaluated for their in vitro antifungal and antibacterial activity. The antifungal profile of 3, 4a, 4b, and 6 indicated that compounds 3a, 3b, 4b, 6a, and 6c have potent antifungal activity compared to clinically prevalent antifungal drugs Fluconazole and Amphotericin-B against Sporothrix schenckii, Trichophyton mentagraphytes, and Candida parapsilosis and compound 3b has been found to be a lead antifungal agent for further study.
authors.affiliation: Department of Chemistry, University of Lucknow, Lucknow 226 007, India. vishnutandon@yahoo.co.in
authors.forename: Vishnu K
authors.initials: VK
authors.lastname: Tandon
authors.forename: Hardesh K
authors.initials: HK
authors.lastname: Maurya
authors.forename: Nripendra N
authors.initials: NN
authors.lastname: Mishra
authors.forename: Praveen K
authors.initials: PK
authors.lastname: Shukla
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D002384:Catalysis; D004353:Drug Evaluation, Preclinical; D008823:Micelles; D008826:Microbial Sensitivity Tests; D009285:Naphthoquinones / Q000737:chemistry* / Q000494:pharmacology*; D010100:Oxygen / Q000737:chemistry*; D013175:Sporothrix / Q000187:drug effects; D014249:Trichophyton / Q000187:drug effects; D014867:Water
chemical_list: D000935:Antifungal Agents; D008823:Micelles; D009285:Naphthoquinones; D014867:Water; C035342:1,4-naphthoquinone; D010100:Oxygen