title: CD40/CD40 ligand interactions in immune responses and pulmonary immunity.
abstract: The CD40 ligand/CD40 pathway is widely recognized for its prominent role in immune regulation and homeostasis. CD40, a member of the tumor necrosis factor receptor family, is expressed by antigen-presenting cells, as well as non-immune cells and tumors. The engagement of the CD40 and CD40 ligands, which are transiently expressed on T cells and other non-immune cells under inflammatory conditions, regulates a wide spectrum of molecular and cellular processes, including the initiation and progression of cellular and humoral adaptive immunity. Based on recent research findings, the engagement of the CD40 with a deregulated amount of CD40 ligand has been implicated in a number of inflammatory diseases. We will discuss the involvement of the CD40 ligand/CD40 interaction in the pathophysiology of inflammatory diseases, including autoimmune diseases, atherothrombosis, cancer, and respiratory diseases.
authors.affiliation: Department of Medical Technology, Nagoya University School of Health Sciences, Nagoya, Japan. kawabe@met.nagoya-u.ac.jp
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Kawabe
authors.forename: Miyoko
authors.initials: M
authors.lastname: Matsushima
authors.forename: Naozumi
authors.initials: N
authors.lastname: Hashimoto
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Imaizumi
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Hasegawa
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000209:etiology; D019013:CD40 Antigens / Q000502:physiology*; D023201:CD40 Ligand / Q000502:physiology*; D006801:Humans; D008168:Lung / Q000276:immunology*; D009369:Neoplasms / Q000209:etiology; D012140:Respiratory Tract Diseases / Q000276:immunology
chemical_list: D019013:CD40 Antigens; D023201:CD40 Ligand