title: Bupropion versus sertraline in the treatment of depressive patients with binge eating disorder: retrospective cohort study.
abstract: This study sought to compare Bupropion versus Sertraline in the treatment of depressed patients with Binge Eating Disorder (BED) prescribed off-label. Medical records of outpatients with diagnosis of BED and Depression (DSM-IV-TR criteria) were selected: 15 patients were treated with bupropion 150 mg/per day, and 15 with sertraline 200 mg/per day. During the screening and control visits (2°-6°-14°-24° week), the selected patients were first weighed and then evaluated using the following questionnaires: Binge Eating Disorder-Clinical Interview (BEDCI), Beck Depression Inventory (BDI), State-Trait Anxiety Inventory X (STAI-X) and Arizona Sexual Experience Scale (ASEX). Both drugs reduced anxious-depressive symptoms and binge frequency: Bupropion showed a better effectiveness in reducing weight and improving sexual performances; weight loss related to it was proportional to the body mass index. Bupropion may be associated with more weight loss in BED, depressed patients than sertraline.
authors.affiliation: Department of Medical and Surgery Specialties, Psychiatry Unit of the University Hospital Policlinico-Vittorio Emanuele of Catania, University of Catania, Via S. Sofia 78, 95100, Catania (Sicily), Italy. c.calandra@unict.it
authors.forename: Carmela
authors.initials: C
authors.lastname: Calandra
authors.forename: Rina Giuseppa
authors.initials: RG
authors.lastname: Russo
authors.forename: Maria
authors.initials: M
authors.lastname: Luca
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D056912:Binge-Eating Disorder / Q000150:complications / Q000188:drug therapy*; D015992:Body Mass Index; D016642:Bupropion / Q000008:administration & dosage / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D050177:Overweight / Q000188:drug therapy / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D012189:Retrospective Studies; D020280:Sertraline / Q000008:administration & dosage / Q000627:therapeutic use*; D020018:Sexual Dysfunctions, Psychological / Q000188:drug therapy; D016896:Treatment Outcome; D015431:Weight Loss / Q000187:drug effects
chemical_list: D000928:Antidepressive Agents; D016642:Bupropion; D020280:Sertraline