title: Botanicals and anti-inflammatories: natural ingredients for rosacea.
abstract: Rosacea is a chronic inflammatory skin condition characterized by cutaneous hypersensitivity. There are many therapeutic options available for the treatment of rosacea, but none are curative. Since the pathogenesis of rosacea remains elusive, it is not surprising that no single treatment is paramount and that many patients find therapies unsatisfactory or even exacerbating. Treatments are prescribed to work in concert with each other in order to ameliorate the common clinical manifestations, which include: papules and pustules, telangiectasias, erythema, gland hypertrophy, and ocular disease. The most validated topical therapies include metronidazole, azelaic acid, and sodium sulfacetamide-sulfur. Many other topical therapies, such as calcineurin inhibitors, benzoyl peroxide, clindamycin, retinoids, topical corticosteroids, and permethrin have demonstrated varying degrees of success. Due to the inconsistent results of the aforementioned therapies patients are increasingly turning to alternative products containing natural ingredients or botanicals to ease inflammation and remit disease. Additional research is needed to elucidate the benefits of these ingredients in the management of rosacea, but some important considerations regarding the natural ingredients with clinical data will be discussed here.
authors.affiliation: Mount Sinai School of Medicine, Department of Dermatology, New York, USA. Jason.emer@mssm.edu
authors.forename: Jason
authors.initials: J
authors.lastname: Emer
authors.forename: Heidi
authors.initials: H
authors.lastname: Waldorf
authors.forename: Diane
authors.initials: D
authors.lastname: Berson
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000627:therapeutic use; D006801:Humans; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use*; D012393:Rosacea / Q000188:drug therapy
chemical_list: D000893:Anti-Inflammatory Agents; D003879:Dermatologic Agents; D028321:Plant Preparations