title: Serum adiponectin, resistin, and circulating soluble receptor for advanced glycation end products in colectomy patients.
abstract: OBJECTIVE
  Surgical trauma and associated complications are frequently related to physiological stress during colectomy. This study evaluated the response of adiponectin, resistin, and circulating soluble receptor for advanced glycation end products (sRAGE) in colectomy patients with or without an enhanced recovery protocol.
  
  
  METHODS
  Serum samples were collected from 44 colectomy patients at 3 timframes. The surgical procedures were laparoscopic (LAP), hand-assisted laparoscopic (HALS), or open colectomy (OPEN). Adiponectin, resistin, and sRAGE levels were determined by ELISA. Repeated measures ANOVA was applied and P values < 0.05 were considered significant.
  
  
  RESULTS
  A total of 132 (44 × 3) sera were used for analysis. Levels of adiponectin was significantly decreased between PREOP and POD3 (P < 0.001). Conversely, concentrations of resistin significantly increased from PREOP to POD1 and returned to baseline value by POD3 (P < 0.001). Serum sRAGE levels were significantly higher in LAP in comparison with HALS (P = 0.004) and OPEN (P < 0.001). sRAGE levels were significantly higher in sera of patients that underwent ERP (P < 0.001).
  
  
  CONCLUSIONS
  Serum adiponectin, resistin, and sRAGE have the potential to develop into a panel of stress markers. Higher sRAGE levels in sera of LAP and ERP patients may be indicative of a protective and syngeristic role for colectomy recovery.
authors.affiliation: Spectrum Health Research, Spectrum Health, Grand Rapids, MI 49503, USA.
authors.forename: Theodor
authors.initials: T
authors.lastname: Asgeirsson
authors.forename: Sen
authors.initials: S
authors.lastname: Zhang
authors.forename: Sok Kean
authors.initials: SK
authors.lastname: Khoo
authors.forename: James H
authors.initials: JH
authors.lastname: Resau
authors.forename: Nadav
authors.initials: N
authors.lastname: Dujovny
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Senagore
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D003082:Colectomy; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000097:blood*; D052243:Resistin / Q000097:blood*
chemical_list: D052242:Adiponectin; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic; D052243:Resistin