title: [Development of a new hydrocarbon extract from the medicinal raw material of Circassian walnut (Juglans regia) and study of its antiparasitic activity].
abstract: The authors developed a technology for preparing a hydrocarbon extract from the medicinal raw material of Circassian walnut (Juglans regia), including its green fruits, green leaves, and fresh roots. To prepare the preparation, they obtained for the first time a new extragent called petroleum Russia that was found to contain more than hundred chemical compounds by chromatography mass spectrometry. The new agent was named irillen. Experiments on albino mice and albino rats established that the new agent was low toxic. The lethal doses of irillen were calculated: LD50 was 16377 +/- 457.5 mg/kg; LD16 = 12986.4 mg/kg; LD84 was 18976.6 mg/kg for albino mice; LD50 was 16998.0 +/- 535.4 mg/kg; LD16 = 12875.3 mg/ kg; LD84 = 18583.4 mg/kg for albino rats. The irillen prepared by the authors should be referred to as a low toxic and practically nontoxic agent (Toxicity Class IV and V). Irillen has a broad spectrum of antiparasitic activity. It is effective in treating toxocariasis in dogs, larval alveolar echinococcosis, ascaridiasis, and eimeriasis in chickens, and siphachiasis.
authors.forename: A V
authors.initials: AV
authors.lastname: Streliaeva
authors.forename: V V
authors.initials: VV
authors.lastname: Polzikov
authors.forename: E S
authors.initials: ES
authors.lastname: Prokina
authors.forename: D V
authors.initials: DV
authors.lastname: Kurilov
authors.forename: N V
authors.initials: NV
authors.lastname: Chebyshev
authors.forename: T A
authors.initials: TA
authors.lastname: Shcheglova
authors.forename: É R
authors.initials: ÉR
authors.lastname: Gasparian
authors.forename: V M
authors.initials: VM
authors.lastname: Sadykov
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000627:therapeutic use; D017162:Ascaridida / Q000187:drug effects* / Q000254:growth & development; D002645:Chickens / Q000469:parasitology; D003048:Coccidiosis / Q000188:drug therapy* / Q000469:parasitology; D004285:Dogs; D004444:Echinococcosis, Hepatic / Q000188:drug therapy* / Q000469:parasitology; D004446:Echinococcus / Q000187:drug effects* / Q000254:growth & development; D021741:Eimeriida / Q000187:drug effects* / Q000254:growth & development; D006838:Hydrocarbons / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D031324:Juglans / Q000737:chemistry*; D007928:Lethal Dose 50; D051379:Mice; D008815:Mice, Inbred Strains / Q000469:parasitology; D009754:Nuts / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D011919:Rats, Inbred Strains / Q000469:parasitology; D012426:Russia; D014120:Toxocariasis / Q000188:drug therapy* / Q000469:parasitology
chemical_list: D000977:Antiparasitic Agents; D006838:Hydrocarbons; D010936:Plant Extracts