title: Chemical Composition, Antioxidant, and Antimicrobial Activities of Lichen Umbilicaria cylindrica (L.) Delise (Umbilicariaceae).
abstract: The phytochemical analysis of methanol and chloroform extracts of Umbilicaria cylindrica was determined by HPLC-UV method. The predominant phenolic compound in both extracts was depsidone, salazinic acid (1). Besides salazinic acid, the tested extracts of U. cylindrica contain norstictic acid (2), methyl-β-orcinol carboxylate (3), ethyl haematommate (4), atranorin (5), and usnic acid (6), in different amounts and relations. The lichen extracts showed comparable and strong antioxidant activity, exhibited higher DPPH and hydroxyl radical scavengings, chelating activity, and inhibitory activity towards lipid peroxidation. The lichen extracts demonstrated important antimicrobial activity against eight strains with MIC values from 15.62 to 62.50 μg/mL. This is the first report of the detail chemical composition and antioxidant activity of the lichen Umbilicaria cylindrica, and the results suggest that this lichen can be used as a new source of the natural antioxidants and the substances with antimicrobial features.
authors.affiliation: Department of Pharmacy, Medical Faculty, University of Kragujevac, 34 000 Kragujevac, Serbia.
authors.forename: Nedeljko T
authors.initials: NT
authors.lastname: Manojlovic
authors.forename: Perica J
authors.initials: PJ
authors.lastname: Vasiljevic
authors.forename: Pavle Z
authors.initials: PZ
authors.lastname: Maskovic
authors.forename: Marina
authors.initials: M
authors.lastname: Juskovic
authors.forename: Gordana
authors.initials: G
authors.lastname: Bogdanovic-Dusanovic