title: Mining predictive biomarker for neoadjuvant chemotherapy in gastric cancer by proteomics.
abstract: OBJECTIVE
  In this study, we applied the SELDI-TOF-MS technique for the identification of gastric cancer-specific protein markers and sample SELDI protein profiling to distinguish gastric cancer patients of the efficacy of neoadjuvant chemotherapy from a no efficacy population.
  
  
  METHODS
  Gastric tissue samples from 8 paired patients with gastric cancer, from whom clinical and histopathological data concerning patients and carcinomas were available, were analyzed. We scanned 8 paired samples (chemotherapy sensitive and insensitive) by SELDI-TOF-MS.
  
  
  RESULTS
  The data generated 409 high sensitive and reproducibly peaks. From the distribution of the peaks, most of the detectable peaks are in the range from 3000-7000m/z. One potential protein at 7044m/z is Guanine nucleotide-binding protein (GBG7_Human 060262).
  
  
  CONCLUSIONS
  In summary, we present novel differential expressed protein profile for neoadjuvant chemotherapy. This data set will help us to understand the mechanism for the chemotherapy resistance. Our data suggested the presence of GBG7 indicate patient will receive better prognosis of neoadjuvant chemotherapy.
authors.affiliation: Department of Gastrointestinal Surgery, Zhejiang University, Hangzhou, China.
authors.forename: Jiajie
authors.initials: J
authors.lastname: Qian
authors.forename: Fuqiang
authors.initials: F
authors.lastname: Li
authors.forename: Jiren
authors.initials: J
authors.lastname: Yu
authors.forename: Zili
authors.initials: Z
authors.lastname: Yang
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D019295:Computational Biology; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D011237:Predictive Value of Tests; D040901:Proteomics; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013274:Stomach Neoplasms / Q000188:drug therapy*
chemical_list: D014408:Biomarkers, Tumor