title: Association of the ZNF804A gene polymorphism rs1344706 with white matter density changes in Chinese schizophrenia.
abstract: BACKGROUND
  ZNF804A gene polymorphism rs1344706, the first genetic risk variant to achieve genome wide significance for schizophrenia, has been linked to neural functional connectivity. Dysconnectivity of WM may be the primary pathological mechanism of schizophrenia. Association of this variant with regional WM density has not been investigated in schizophrenic patients.
  
  
  METHODS
  69 healthy controls and 80 patients with schizophrenia underwent genotyping of rs1344706 SNPs, and were examined for WM density (T1-weighted MRI). The association of rs1344706 with WM changes in schizophrenia patients and healthy controls was analyzed using a full-factorial 2×2 analysis of variance.
  
  
  RESULTS
  1. There was an interaction on WM density in the left prefrontal lobe between the rs1344706 genotype and schizophrenic diagnosis, where the risk T allele carriers presented higher WM density in the schizophrenia patients and lower WM density in healthy controls in comparison with the non-risk allele carriers. 2. The risk allele was associated with an increased WM density of the bilateral hippocampus in both the patients and the healthy group.
  
  
  CONCLUSIONS
  The influence of antipsychotics to the white matter in schizophrenic patients was not fully eliminated.
  
  
  CONCLUSIONS
  The ZNF804A variant may confer risk for schizophrenia by exerting its effects on the WM in the left prefrontal lobe together with other risk factors for schizophrenia.
authors.affiliation: Mental Health Institute, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China.
authors.forename: Qinling
authors.initials: Q
authors.lastname: Wei
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Kang
authors.forename: Feici
authors.initials: F
authors.lastname: Diao
authors.forename: Baoci
authors.initials: B
authors.lastname: Shan
authors.forename: Leijun
authors.initials: L
authors.lastname: Li
authors.forename: Liangrong
authors.initials: L
authors.lastname: Zheng
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Guo
authors.forename: Chunlei
authors.initials: C
authors.lastname: Liu
authors.forename: Jinbei
authors.initials: J
authors.lastname: Zhang
authors.forename: Jingping
authors.initials: J
authors.lastname: Zhao
mesh_terms: D000328:Adult; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies / Q000379:methods; D006580:Genetic Carrier Screening; D014644:Genetic Variation; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000235:genetics*; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D017397:Prefrontal Cortex / Q000473:pathology*; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics* / Q000473:pathology*; D055815:Young Adult
chemical_list: D051741:Kruppel-Like Transcription Factors; C540527:ZNF804A protein, human