title: Validation of a brachial cuff-based method for estimating central systolic blood pressure.
abstract: The prognostic value of central systolic blood pressure has been established recently. At present, its noninvasive assessment is limited by the need of dedicated equipment and trained operators. Moreover, ambulatory and home blood pressure monitoring of central pressures are not feasible. An algorithm enabling conventional automated oscillometric blood pressure monitors to assess central systolic pressure could be of value. We compared central systolic pressure, calculated with a transfer-function like method (ARCSolver algorithm), using waveforms recorded with a regular oscillometric cuff suitable for ambulatory measurements, with simultaneous high-fidelity invasive recordings, and with noninvasive estimations using a validated device, operating with radial tonometry and a generalized transfer function. Both studies revealed a good agreement between the oscillometric cuff-based central systolic pressure and the comparator. In the invasive study, composed of 30 patients, mean difference between oscillometric cuff/ARCSolver-based and invasive central systolic pressures was 3.0 mm Hg (SD: 6.0 mm Hg) with invasive calibration of brachial waveforms and -3.0 mm Hg (SD: 9.5 mm Hg) with noninvasive calibration of brachial waveforms. Results were similar when the reference method (radial tonometry/transfer function) was compared with invasive measurements. In the noninvasive study, composed of 111 patients, mean difference between oscillometric cuff/ARCSolver-derived and radial tonometry/transfer function-derived central systolic pressures was -0.5 mm Hg (SD: 4.7 mm Hg). In conclusion, a novel transfer function-like algorithm, using brachial cuff-based waveform recordings, is suited to provide a realistic estimation of central systolic pressure.
authors.affiliation: Cardiology Department, Klinikum Wels-Grieskirchen, Grieskirchnerstrasse 42, 4600 Wels, Austria. thomas.weber3@liwest.at
authors.forename: Thomas
authors.initials: T
authors.lastname: Weber
authors.forename: Siegfried
authors.initials: S
authors.lastname: Wassertheurer
authors.forename: Martin
authors.initials: M
authors.lastname: Rammer
authors.forename: Edwin
authors.initials: E
authors.lastname: Maurer
authors.forename: Bernhard
authors.initials: B
authors.lastname: Hametner
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Mayer
authors.forename: Johannes
authors.initials: J
authors.lastname: Kropf
authors.forename: Bernd
authors.initials: B
authors.lastname: Eber
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D001794:Blood Pressure; D001795:Blood Pressure Determination / Q000379:methods; D015924:Blood Pressure Monitors; D001916:Brachial Artery; D002138:Calibration; D002404:Catheterization / Q000379:methods; D015331:Cohort Studies; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009991:Oscillometry / Q000295:instrumentation*; D017534:Radial Artery; D012680:Sensitivity and Specificity; D055815:Young Adult