title: Using elastic light scattering of red blood cells to detect infection of malaria parasite.
abstract: To develop noninvasive diagnosis of malaria, we studied the light-scattering pattern of healthy and 2% Plasmodium falciparum malaria parasitized red blood cells. By measuring the wavelength-dependent scattering at discrete angles of both forward and backward directions, we found that the signal can clearly distinguish between healthy and ring stage infected red blood cells. In particular, we demonstrated the first backward scattering measurement, which enables elastic light scattering as a promising noninvasive diagnostic tool for malaria.
authors.affiliation: Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA. leeseung@umich.edu
authors.forename: Seungjun
authors.initials: S
authors.lastname: Lee
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
mesh_terms: D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004912:Erythrocytes / Q000469:parasitology*; D005260:Female; D006801:Humans; D008288:Malaria / Q000097:blood* / Q000175:diagnosis* / Q000469:parasitology; D008297:Male; D009391:Nephelometry and Turbidimetry / Q000379:methods*; D010963:Plasmodium falciparum / Q000302:isolation & purification*; D012031:Refractometry / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity