title: [Drugs in pregnancy: study in the EFEMERIS database (2004 to 2008)].
abstract: OBJECTIVE
  To analyze the evolution of drug prescriptions during pregnancy from 2004 to 2008 in Haute-Garonne (France) and the impact of recommendations concerning drugs in pregnancy sent by French health authorities (AFSSAPS) and French college of gynaecologists and obstetricians to health professionals during the period.
  
  
  METHODS
  This descriptive study of reimbursed drug prescriptions during pregnancy concerns women included in the EFEMERIS database who have given birth from July 1st, 2004 to June 30th, 2008. The health insurance service records of Haute-Garonne were used.
  
  
  RESULTS
  Taking into account 2 subsequent delistings of drugs for reimbursement during the period, we observed a significant increase of reimbursed drug prescriptions dispensed to pregnant women (8.7 different substances for women who have given birth in 2004 and 9.4 in 2008). Vitamins, immunserums, immunoglobulins and homeopathy prescriptions have especially increased. Paracetamol, iron, folic acid and phloroglucinol were the most prescribed drugs during all the periods.
  
  
  CONCLUSIONS
  Since 2004, EFEMERIS represents a monitoring centre for the prescription of reimbursed drugs to pregnant women. This analysis allowed to exhibit trends in prescription patterns. Most of the alerts or recommendations had a positive but limited impact.
authors.affiliation: EA3696, unité de pharmacoépidémiologie, service de pharmacologie clinique, faculté de médecine, université de Toulouse, CHU de Toulouse 37, allées Jules-Guesde, Toulouse, France. hurault@cict.fr
authors.forename: C
authors.initials: C
authors.lastname: Hurault-Delarue
authors.forename: I
authors.initials: I
authors.lastname: Lacroix
authors.forename: S
authors.initials: S
authors.lastname: Vidal
authors.forename: J-L
authors.initials: JL
authors.lastname: Montastruc
authors.forename: C
authors.initials: C
authors.lastname: Damase-Michel
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage; D016208:Databases, Factual / Q000706:statistics & numerical data; D011307:Drug Prescriptions / Q000706:statistics & numerical data*; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage; D006801:Humans; D007106:Immune Sera / Q000008:administration & dosage; D007136:Immunoglobulins / Q000008:administration & dosage; D007348:Insurance, Health / Q000706:statistics & numerical data; D007501:Iron / Q000008:administration & dosage; D008419:Materia Medica / Q000008:administration & dosage; D010696:Phloroglucinol / Q000008:administration & dosage; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D014815:Vitamins / Q000008:administration & dosage
chemical_list: D007106:Immune Sera; D007136:Immunoglobulins; D008419:Materia Medica; D014815:Vitamins; D000082:Acetaminophen; D005492:Folic Acid; D010696:Phloroglucinol; D007501:Iron