title: Single-center experience in systemic stress and short-term morbidity of single-incision cholecystectomy.
abstract: Single-incision laparoscopic surgery (SILS) aims to reduce the number and size of skin incisions. The authors compared systemic stress and perioperative outcome of SILS and laparoscopic (LAP) cholecystectomy. Twenty-nine subjects (8 males and 21 females; mean age = 47 years; mean body mass index = 27) were included in the study. There was no statistical difference in mean operative time (LAP = 89 minutes; SILS = 113 minutes; P = ns), and no intraoperative complications were reported. There were no statistically significant differences observed in white cell count, C-reactive protein, interleukin-6, and tumor necrosis factor-α between SILS and LAP groups. The mean hospital length of stay (LAP = 1.8 days; SILS = 1.4 days) and Visual Analogue Scale scores for pain at 6 hours (LAP = 5.14; SILS = 4.46) and 24 hours (LAP = 3.9; SILS = 2.815) were similar with no perioperative morbidity. These results suggest that the systemic stress response in LAP and SILS cholecystectomy does not appear to be significantly different. SILS cholecystectomy appears safe with no perioperative morbidity or complications encountered in this series.
authors.affiliation: Imperial College London, London, UK.
authors.forename: Farid
authors.initials: F
authors.lastname: Froghi
authors.forename: Mikael H
authors.initials: MH
authors.lastname: Sodergren
authors.forename: Victoria J
authors.initials: VJ
authors.lastname: Wright
authors.forename: Ross
authors.initials: R
authors.lastname: Coomber
authors.forename: Alan P
authors.initials: AP
authors.lastname: Courtney
authors.forename: Ara
authors.initials: A
authors.lastname: Darzi
authors.forename: Paraskevas
authors.initials: P
authors.lastname: Paraskeva
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002097:C-Reactive Protein / Q000032:analysis; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects* / Q000379:methods* / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D007902:Length of Stay; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D010147:Pain Measurement; D018709:Statistics, Nonparametric; D013312:Stress, Physiological; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein