title: Pulse-pressure variation predicts fluid responsiveness during heart displacement for off-pump coronary artery bypass surgery.
abstract: OBJECTIVE
  The aim of this study was to evaluate the ability of pulse-pressure variation to predict fluid responsiveness during heart displacement for off-pump coronary artery bypass surgery using receiver operating characteristic analysis.
  
  
  METHODS
  A prospective study.
  
  
  METHODS
  A clinical study in a single cardiac anesthesia institution.
  
  
  METHODS
  Thirty-five patients undergoing elective off-pump coronary artery bypass surgery.
  
  
  RESULTS
  Central venous pressure, pulmonary arterial occlusion pressure, pulse-pressure variation, and cardiac index were measured 5 minutes after revascularization of the left anterior descending coronary artery and before heart displacement. Immediately after heart displacement for revascularization of the left circumflex artery, and 10 minutes after fluid loading with hydroxyethyl starch 6% (10 mL/kg) during heart displacement, the measurements were repeated. Patients whose cardiac indices increased by ≥15% from fluid loading were defined as responders. After heart displacement, only pulse-pressure variation showed significant difference between the responders and nonresponders (13.48 ± 6.42 v 7.33 ± 3.81, respectively; p < 0.01). Moreover, receiver operating characteristic analysis showed that pulse-pressure variation successfully predicted fluid responsiveness (area under the curve = 0.839, p = 0.0001). Pulse-pressure variation >7.69% identified the responders, with a sensitivity of 86% and a specificity of 83%.
  
  
  CONCLUSIONS
  Pulse-pressure variation successfully predicted fluid responsiveness and would be useful in guiding fluid management during heart displacement for off-pump coronary artery bypass surgery.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Jong-Hwan
authors.initials: JH
authors.lastname: Lee
authors.forename: Yunseok
authors.initials: Y
authors.lastname: Jeon
authors.forename: Jae-Hyon
authors.initials: JH
authors.lastname: Bahk
authors.forename: Nam-Su
authors.initials: NS
authors.lastname: Gil
authors.forename: Ki-Bong
authors.initials: KB
authors.lastname: Kim
authors.forename: Deok Man
authors.initials: DM
authors.lastname: Hong
authors.forename: Hyun Joo
authors.initials: HJ
authors.lastname: Kim
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D002245:Carbon Dioxide / Q000097:blood; D002302:Cardiac Output; D002496:Central Venous Pressure / Q000502:physiology; D047549:Coronary Artery Bypass, Off-Pump; D004562:Electrocardiography; D005260:Female; D005440:Fluid Therapy; D006321:Heart / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D010100:Oxygen / Q000097:blood; D010952:Plasma Substitutes; D011446:Prospective Studies; D011651:Pulmonary Artery / Q000502:physiology; D011652:Pulmonary Circulation / Q000502:physiology; D012372:ROC Curve
chemical_list: D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes; D002245:Carbon Dioxide; D010100:Oxygen