title: Hepatocellular carcinoma in HIV hepatitis C virus.
abstract: OBJECTIVE
  Recent data showed that in some settings with adequate resources liver diseases rank first among the causes of death in persons living with HIV (PLHIV). Although liver decompensation is the first cause of hepatic death in PLHIV, hepatocellular carcinoma (HCC) is also emerging as one of the causes of hepatic death in PLHIV. This review analyzes the main data published on HCC in PLHIV in the last 3 years.
  
  
  RESULTS
  HCC is more common in persons living with HIV than in general population. In PLHIV with a late diagnosis of HCC, less treatable cases and lower survival were described in retrospective studies. New treatment strategies are available for advanced HCC but there are few data available on PLHIV and some open issues. Nevertheless, screening of HIV-infected patients suspected to have cirrhosis seems to be useful and is mandatory in PLHIV and hepatitis C virus (HCV) induced cirrhosis. Together with screening of patients at risk and an early diagnosis, aggressive treatment of the neoplasia including treatment of relapses and maintenance of HIV suppression are the best management strategies for HCC in PLHIV. The role of liver transplantation remains controversial.
  
  
  CONCLUSIONS
  In the last years, HCC is becoming an important issue in PLHIV. Prevention, screening, and treatment strategies for HCC need to be included in the management of PLHIV.
authors.affiliation: Department of Infectious Diseases, AO Ospedale Niguarda Ca' Granda, Milano, Italy. massimopuoti@libero.it
authors.forename: Massimo
authors.initials: M
authors.lastname: Puoti
authors.forename: Roberto
authors.initials: R
authors.lastname: Rossotti
authors.forename: Annalisa
authors.initials: A
authors.lastname: Garlaschelli
authors.forename: Raffaele
authors.initials: R
authors.lastname: Bruno
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000821:virology*; D060085:Coinfection; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology / Q000821:virology; D016174:Hepacivirus; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology / Q000821:virology; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000453:epidemiology / Q000517:prevention & control / Q000821:virology; D008113:Liver Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000821:virology*; D012307:Risk Factors