title: Role of long non-coding RNAs in gene regulation and oncogenesis.
abstract: OBJECTIVE
  This article aims to review recent studies on the biological characteristics of long non-coding RNAs (lncRNAs), transcription regulation by lncRNAs, and the results of recent studies on the mechanism of action of lncRNAs in tumor development.
  
  
  METHODS
  The data cited in this review were mainly obtained from the articles listed in PubMed and HighWire that were published from January 2002 to June 2010. The search terms were "long non-coding RNA", "gene regulation", and "tumor".
  
  
  METHODS
  The mechanism of lncRNAs in gene expression regulation, and tumors concerned with lncRNAs and the role of lncRNAs in oncogenesis.
  
  
  RESULTS
  lncRNAs play an important role in transcription regulation by controlling chromatin remodeling, transcriptional control, and post-transcriptional controlling. lncRNAs are involved in many kinds of tumors and play key roles as both suppressing and promoting factors.
  
  
  CONCLUSIONS
  lncRNAs could perfectly regulate the balance of gene expression system and play important roles in oncogenic cellular transformation.
authors.affiliation: Department of Infectious Disease, First Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450000, China. panfirstfeng@163.com
authors.forename: Yan-feng
authors.initials: YF
authors.lastname: Pan
authors.forename: Lei
authors.initials: L
authors.lastname: Feng
authors.forename: Xian-qiang
authors.initials: XQ
authors.lastname: Zhang
authors.forename: Li-jie
authors.initials: LJ
authors.lastname: Song
authors.forename: Hong-xia
authors.initials: HX
authors.lastname: Liang
authors.forename: Zhi-qin
authors.initials: ZQ
authors.lastname: Li
authors.forename: Feng-bao
authors.initials: FB
authors.lastname: Tao
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D005786:Gene Expression Regulation / Q000235:genetics / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D022661:RNA, Untranslated / Q000235:genetics*
chemical_list: D022661:RNA, Untranslated