title: Spi2 gene polymorphism is not associated with recurrent airway obstruction and inflammatory airway disease in thoroughbred horses.
abstract: The aim was to detect the presence of polymorphisms at exons 1, 2, 3 and 4 of the Spi2 gene, and evaluate a possible association between them and recurrent airway obstruction (RAO) or inflammatory airway disease (IAD) in thoroughbred horses, through single-strand conformational-polymorphism (SSCP) screening. Although polymorphism was not detected in exons 1, 2 and 3, three alleles and six genotypes were identified in exon 4. The frequencies of allele A (0.6388) and genotype AA (0.3888) were higher in horses affected by RAO, although no association was found between polymorphism and horses with either RAO or IAD.
authors.affiliation: Departamento de Clínica de Grandes Animais, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
authors.forename: Aline Correa
authors.initials: AC
authors.lastname: da Silva
authors.forename: Karin Erica
authors.initials: KE
authors.lastname: Brass
authors.forename: Elgion
authors.initials: E
authors.lastname: da Silva Loreto
authors.forename: Myriam Elizabeth
authors.initials: ME
authors.lastname: Vinocur
authors.forename: Ricardo
authors.initials: R
authors.lastname: Pozzobon
authors.forename: Marcos
authors.initials: M
authors.lastname: da Silva Azevedo