title: The 27-bp VNTR polymorphism in intron 4 of the human eNOS gene in healthy Singaporean Chinese, Indians, and Malays.
abstract: Human endothelial nitric oxide synthase (eNOS) is one isoform of the nitric oxide synthases that are responsible for nitric oxide synthesis from L-arginine. The gene encoding eNOS contains a 27-bp VNTR polymorphism in intron 4. We report here for the first time the presence of a novel allele 3, which was absent in all other populations studied to date, in 1.7% each of Singaporean Indians and Malays. We also detected the presence of a novel genotype 3/5 in 3.4% each of Singaporean Indians and Malays. Allele 6, which was absent in Han Chinese from northern China and Taiwan and was also absent in Indians from the Indian subcontinent, was found in 2.1% of Singaporean Chinese and in 0.3% of Singaporean Indians.
authors.affiliation: Natural Sciences and Science Education, National Institute of Education, Nanyang Technological University, 1 Nanyang Walk, Singapore, 637616, Singapore. yikyuen.gan@nie.edu.sg
authors.forename: Yik Yuen
authors.initials: YY
authors.lastname: Gan
authors.forename: Chuan Fei
authors.initials: CF
authors.lastname: Chen
mesh_terms: D044466:Asian People / Q000208:ethnology / Q000235:genetics; D005787:Gene Frequency; D006801:Humans; D007194:India / Q000208:ethnology; D007438:Introns; D008296:Malaysia / Q000208:ethnology; D018598:Minisatellite Repeats; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D011110:Polymorphism, Genetic; D012846:Singapore
chemical_list: D052250:Nitric Oxide Synthase Type III