title: CTLA-4 gene polymorphism and the risk of systemic lupus erythematosus in the Chinese population.
abstract: Several variants of CTLA-4 have been reported to be associated with susceptibility systemic lupus erythematosus (SLE); however, findings have been inconsistent across different populations. Using a case-control study design, we have investigated the role of CTLA-4 polymorphism at positions -1661 and -1722 on SLE susceptibility in our Chinese SLE population in central China's Hubei province. Samples were collected from 148 SLE patients and 170 healthy controls. Polymerase chain reaction restriction fragments length polymorphism (PCR-RFLP) was used to analyze the genotypes of the two sites. Statistically significant difference was observed in genotypes for -1722, but not for -1661. The frequency of the T allele on the -1722 SNP was significantly increased in SLE patients: 57.8% versus 40.6% in controls (P < 0.001, OR = 2.002). While the detected C allele frequency in the controls was significantly elevated in comparison to that in the SLE patients (59.4% versus 42.2%). On the contrary, no association was found between SLE and CTLA-4 polymorphism at position -1661.
authors.affiliation: Renmin Hospital of Wuhan University, Wuhan 430060, China.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Taha Khalaf
authors.forename: Ji-Quan
authors.initials: JQ
authors.lastname: Song
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Gao
authors.forename: Xiang-Ping
authors.initials: XP
authors.lastname: Yu
authors.forename: Tie-Chi
authors.initials: TC
authors.lastname: Lei
mesh_terms: D060908:CTLA-4 Antigen / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic
chemical_list: D060908:CTLA-4 Antigen