title: Control of coronary blood flow during exercise.
abstract: During exercise, coronary blood flow increases to match the augmented myocardial oxygen demand because of tachycardia. Coronary vasodilation during exercise is via a combination of feedforward and feedback control mechanisms. Feedforward control is mediated by sympathetic β-adrenoceptor vasodilation. Feedback vasodilator control is via a novel hypothesis where adenine nucleotides released from red blood cells act on endothelial purinergic receptors.
authors.affiliation: Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195-7920, USA.
authors.forename: Mark W
authors.initials: MW
authors.lastname: Gorman
authors.forename: Eric O
authors.initials: EO
authors.lastname: Feigl
mesh_terms: D000227:Adenine Nucleotides / Q000097:blood / Q000494:pharmacology; D003326:Coronary Circulation / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D010101:Oxygen Consumption / Q000502:physiology; D011983:Receptors, Purinergic / Q000097:blood / Q000378:metabolism; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology
chemical_list: D000227:Adenine Nucleotides; D011983:Receptors, Purinergic