title: Bioactivation of 4-Ipomeanol by a CYP4B enzyme in bovine lung and inhibition by HET0016.
authors.affiliation: Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA.
authors.forename: O T
authors.initials: OT
authors.lastname: Parkinson
authors.forename: E J
authors.initials: EJ
authors.lastname: Kelly
authors.forename: E
authors.initials: E
authors.lastname: Bezabih
authors.forename: D
authors.initials: D
authors.lastname: Whittington
authors.forename: A E
authors.initials: AE
authors.lastname: Rettie
mesh_terms: D000578:Amidines / Q000494:pharmacology*; D000818:Animals; D000906:Antibodies; D001189:Aryl Hydrocarbon Hydroxylases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D001681:Biological Assay; D001711:Biotransformation; D002417:Cattle; D008168:Lung / Q000201:enzymology*; D008861:Microsomes; D015394:Molecular Structure; D011817:Rabbits; D013729:Terpenes / Q000737:chemistry / Q000378:metabolism*; D013928:Thromboxane A2; D014118:Toxins, Biological / Q000493:pharmacokinetics
chemical_list: D000578:Amidines; D000906:Antibodies; C000708209:HET0016; D013729:Terpenes; D014118:Toxins, Biological; D013928:Thromboxane A2; D001189:Aryl Hydrocarbon Hydroxylases; C095029:cytochrome P-450 CYP4B1; C001470:4-ipomeanol