title: Practical experience of ustekinumab in the treatment of psoriasis: experience from a multicentre, retrospective case cohort study across the U.K. and Ireland.
abstract: BACKGROUND
  There are limited data on the use of ustekinumab outside of clinical trials.
  
  
  OBJECTIVE
  To assess the efficacy and safety of ustekinumab in patients with severe psoriasis attending 10 dermatology centres in the U.K. and Ireland.
  
  
  METHODS
  A retrospective case-note review of 129 patients with psoriasis treated with ustekinumab.
  
  
  RESULTS
  Baseline Psoriasis Area and Severity Index (PASI) was 22·9±10·1 (mean±SD). After 16weeks of treatment with ustekinumab PASI 75 (75% reduction in PASI) was observed in 63·0% (n=80/127) of patients, although four patients required concomitant therapy at the 16-week time point. Previous biologic use did show a small, non-significant trend towards treatment failure. A PASI 75 response was seen in 29·4% (n=5/17) of individuals weighing 90-100kg and treated with the standard 45mg ustekinumab dose compared with PASI 75 of 70·3%, 71·4%, 75·0% and 55·6% for weight groups <80, 80-90, 100-110 and >110kg, respectively (P=0·024). Ustekinumab therapy was well tolerated; serious adverse events were observed in 2·3% (n=3/129) of patients.
  
  
  CONCLUSIONS
  Ustekinumab is a novel biologic agent for psoriasis. When used in everyday clinical practice it demonstrates high levels of short-term therapeutic efficacy with an acceptable short-term safety profile.
authors.affiliation: Dermatological Sciences, Salford Royal Hospital, The University of Manchester, Manchester Academic Health Science Centre, Manchester M6 8HD, UK.
authors.forename: P M
authors.initials: PM
authors.lastname: Laws
authors.forename: A M
authors.initials: AM
authors.lastname: Downs
authors.forename: R
authors.initials: R
authors.lastname: Parslew
authors.forename: B
authors.initials: B
authors.lastname: Dever
authors.forename: C H
authors.initials: CH
authors.lastname: Smith
authors.forename: J N
authors.initials: JN
authors.lastname: Barker
authors.forename: B
authors.initials: B
authors.lastname: Moriarty
authors.forename: R
authors.initials: R
authors.lastname: Murphy
authors.forename: B
authors.initials: B
authors.lastname: Kirby
authors.forename: A D
authors.initials: AD
authors.lastname: Burden
authors.forename: S
authors.initials: S
authors.lastname: McBride
authors.forename: A V
authors.initials: AV
authors.lastname: Anstey
authors.forename: S
authors.initials: S
authors.lastname: O'Shea
authors.forename: N
authors.initials: N
authors.lastname: Ralph
authors.forename: C
authors.initials: C
authors.lastname: Buckley
authors.forename: C E M
authors.initials: CE
authors.lastname: Griffiths
authors.forename: R B
authors.initials: RB
authors.lastname: Warren
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D001688:Biological Products / Q000627:therapeutic use*; D015992:Body Mass Index; D017281:Cost of Illness; D003879:Dermatologic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome; D000069549:Ustekinumab
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D001688:Biological Products; D003879:Dermatologic Agents; D000069549:Ustekinumab