title: An influenza N1 neuraminidase-specific  monoclonal antibody with broad neuraminidase  inhibition activity against H5N1 HPAI viruses.
abstract: H5N1 avian influenza continues to be a potential pandemic threat. Several vaccine candidates based on potentially pandemic influenza strains and antiviral drugs have been tested in preclinical and clinical studies. The data obtained so far have shown some promise, but have also revealed some shortcomings with both of these approaches. We have identified and characterized an H5N1 neuraminidasespecific monoclonal antibody which specifically inhibits N1 neuraminidase activity of highly pathogenic avian influenza (HPAI) strains from clades 1 and 2. We have also shown the protective efficacy of this antibody in animal challenge models using homologous virus. Specific and effective inhibition of N1 NA could make this mAb a useful therapeutic tool in the treatment of human infection, in particular with oseltamivirand zanamivir-resistant strains of HPAI.
authors.affiliation: Fraunhofer USA Center for Molecular Biotechnology, Newark, DE, USA.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Shoji
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Chichester
authors.forename: Gene A
authors.initials: GA
authors.lastname: Palmer
authors.forename: Christine E
authors.initials: CE
authors.lastname: Farrance
authors.forename: Robert
authors.initials: R
authors.lastname: Stevens
authors.forename: Michelle
authors.initials: M
authors.lastname: Stewart
authors.forename: Lauren
authors.initials: L
authors.lastname: Goldschmidt
authors.forename: Varough
authors.initials: V
authors.lastname: Deyde
authors.forename: Larisa
authors.initials: L
authors.lastname: Gubareva
authors.forename: Alexander
authors.initials: A
authors.lastname: Klimov
authors.forename: Vadim
authors.initials: V
authors.lastname: Mett
authors.forename: Vidadi
authors.initials: V
authors.lastname: Yusibov
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000276:immunology*; D057134:Antibodies, Neutralizing / Q000008:administration & dosage / Q000276:immunology*; D000914:Antibodies, Viral / Q000008:administration & dosage / Q000276:immunology*; D001835:Body Weight; D004195:Disease Models, Animal; D005260:Female; D053124:Influenza A Virus, H5N1 Subtype / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009439:Neuraminidase / Q000276:immunology*; D009976:Orthomyxoviridae Infections / Q000517:prevention & control*; D012376:Rodent Diseases / Q000517:prevention & control; D016019:Survival Analysis; D014764:Viral Proteins / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D014764:Viral Proteins; C487630:NA protein, influenza A virus; D009439:Neuraminidase