title: Mannan-binding lectin and mannan-binding lectin-associated serine protease 2 in acute pancreatitis.
abstract: OBJECTIVE
  Complement activation may play a prominent role in acute pancreatitis (AP). Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) participate in complement activation. The objective of the present study was to evaluate the role of MBL and MASP-2 as markers in AP with regard to etiology, inflammatory activity, severity, and development of multiorgan failure.
  
  
  METHODS
  Sixty patients with AP were included. All patients were diagnosed and treated according to a standardized regimen. Blood samples were obtained immediately on admission and again on days 1, 2, and 14.
  
  
  RESULTS
  Both MBL (P < 0.001) and MASP-2 (P = 0.002) levels changed significantly over time, but without any significant relation to severity, multiorgan failure, or mortality. We found significantly higher levels of MBL (P = 0.04) in alcohol- than in gallstone-induced AP, but no significant difference in MASP-2 levels.
  
  
  CONCLUSIONS
  The MBL and MASP-2 acted as acute-phase reactants, but overall, they were not markers for severity, multiorgan failure, nor for mortality in AP. Our results suggest that MBL and MASP-2 play only a minor role in the inflammatory response in AP.
authors.affiliation: Department of Surgery K, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Sweden.
authors.forename: Srdan
authors.initials: S
authors.lastname: Novovic
authors.forename: Anders M
authors.initials: AM
authors.lastname: Andersen
authors.forename: Annette K
authors.initials: AK
authors.lastname: Ersbøll
authors.forename: Lars N
authors.initials: LN
authors.lastname: Jorgensen
authors.forename: Hans J
authors.initials: HJ
authors.lastname: Nielsen
authors.forename: Jens C
authors.initials: JC
authors.lastname: Jensenius
authors.forename: Mark B
authors.initials: MB
authors.lastname: Hansen
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D003167:Complement Activation; D005260:Female; D042882:Gallstones / Q000150:complications; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D037601:Mannose-Binding Lectin / Q000097:blood*; D050606:Mannose-Binding Protein-Associated Serine Proteases / Q000378:metabolism*; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000201:enzymology / Q000209:etiology* / Q000276:immunology / Q000401:mortality; D010195:Pancreatitis / Q000201:enzymology* / Q000209:etiology / Q000276:immunology / Q000401:mortality; D019512:Pancreatitis, Alcoholic / Q000201:enzymology* / Q000209:etiology / Q000276:immunology / Q000401:mortality; D011379:Prognosis; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors; D055815:Young Adult
chemical_list: C508600:IL6 protein, human; D018836:Inflammation Mediators; D015850:Interleukin-6; D037601:Mannose-Binding Lectin; D002097:C-Reactive Protein; C105296:MASP2 protein, human; D050606:Mannose-Binding Protein-Associated Serine Proteases