title: One-pot synthesis of indole-fused scaffolds via gold-catalyzed tandem annulation reactions of 1,2-bis(alkynyl)-2-en-1-ones with indoles.
abstract: The gold-catalyzed tandem cyclization of 1,2-bis(alkynyl)-2-en-1-ones with indoles offers an efficient and straightforward route to indole-fused polycyclic systems. The process is realized through a cascade carbonyl-yne cyclization/Friedel-Crafts/indole-yne cyclization sequence catalyzed by a single-pot catalyst of gold.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Xie
authors.forename: Xiangwei
authors.initials: X
authors.lastname: Du
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Chen
authors.forename: Yuanhong
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006046:Gold / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D000480:Alkynes; D007211:Indoles; D006046:Gold