title: Free radical scavenging activity-guided isolation of a diterpenoid from Plectranthus punuctatus.
abstract: Free radical scavenging activity-guided investigation of the acetone extract of Plectranthus punuctatus (L'Her) (Lamiaceae) resulted in the isolation of a novel diterpenoid 3,11,12,14,19-pentahydroxy-5,8,11,13-abietatraen-7-pyran[4,6]-16-dione whose structure was elucidated based on spectral evidence. The isolated compound showed a significant antioxidant activity in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and deoxyribose degradation assays with IC50 values of 9.65 microg/mL and 5.25 microg/mL, respectively.
authors.affiliation: Aromatic, Medicinal and Bioenergy Research Case Team Laboratory, Institute of Ethiopian Agricultural Research, Addis Ababa, Ethiopia.
authors.forename: Wossen
authors.initials: W
authors.lastname: Kebede
authors.forename: Daniel
authors.initials: D
authors.lastname: Bisrat
authors.forename: Kaleab
authors.initials: K
authors.lastname: Asres
mesh_terms: D004224:Diterpenes / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry*; D015394:Molecular Structure; D031346:Plectranthus / Q000737:chemistry*
chemical_list: C562087:3,11,12,14,19-pentahydroxy-5,8,11,13-abietatraen-7-pyran(4,6)-16-dione; D004224:Diterpenes; D016166:Free Radical Scavengers