title: Bone, inflammation, and inflammatory bowel disease.
abstract: Osteoporosis is a leading cause of morbidity in patients with inflammatory bowel disease (IBD). Bone loss is an early systemic process and occurs even before clinical disease manifests. Bone disease is attributed to vitamin D deficiency, steroid use, and/or systemic inflammation. In this review, we discuss the molecular pathways of bone loss mediated by inflammatory cytokines and other mediators. Further research will hopefully clarify the mechanisms of inflammation-induced bone loss in IBD and guide effective treatment modalities.
authors.affiliation: Department of Gastroenterology, Maimonides Medical Center, Brooklyn, NY 11201, USA. maagrawal@maimonidesmed.org
authors.forename: Manasi
authors.initials: M
authors.lastname: Agrawal
authors.forename: Shitij
authors.initials: S
authors.lastname: Arora
authors.forename: Jianjun
authors.initials: J
authors.lastname: Li
authors.forename: Rabin
authors.initials: R
authors.lastname: Rahmani
authors.forename: Li
authors.initials: L
authors.lastname: Sun
authors.forename: Adam F
authors.initials: AF
authors.lastname: Steinlauf
authors.forename: Jeffrey I
authors.initials: JI
authors.lastname: Mechanick
authors.forename: Mone
authors.initials: M
authors.lastname: Zaidi
mesh_terms: D002450:Cell Communication / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D015212:Inflammatory Bowel Diseases / Q000503:physiopathology*; D010006:Osteoblasts / Q000166:cytology / Q000502:physiology; D010010:Osteoclasts / Q000166:cytology / Q000502:physiology; D010024:Osteoporosis / Q000503:physiopathology*; D015398:Signal Transduction / Q000502:physiology; D014808:Vitamin D Deficiency / Q000503:physiopathology