title: MicroRNA destabilization enables dynamic regulation of the miR-16 family in response to cell-cycle changes.
abstract: The miR-16 family, which targets genes important for the G1-S transition, is a known modulator of the cell cycle, and members of this family are often deleted or downregulated in many types of cancers. Here, we report the reciprocal relationship-that of the cell cycle controlling the miR-16 family. Levels of this family increase rapidly as cells are arrested in G0. Conversely, as cells are released from G0 arrest, levels of the miR-16 family rapidly decrease. Such rapid changes are made possible by the unusual instabilities of several family members. The repression mediated by the miR-16 family is sensitive to these cell-cycle changes, which suggests that the rapid upregulation of the miR-16 family reinforces cell-cycle arrest in G0. Upon cell-cycle re-entry, the rapid decay of several members allows levels of the family to decrease, alleviating repression of target genes and allowing proper resumption of the cell cycle.
authors.affiliation: Howard Hughes Medical Institute, Cambridge, MA 02139, USA.
authors.forename: Olivia S
authors.initials: OS
authors.lastname: Rissland
authors.forename: Sue-Jean
authors.initials: SJ
authors.lastname: Hong
authors.forename: David P
authors.initials: DP
authors.lastname: Bartel
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000235:genetics*; D016193:G1 Phase / Q000235:genetics; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism*; D041681:NIH 3T3 Cells; D020871:RNA Stability; D016196:S Phase / Q000235:genetics
chemical_list: D035683:MicroRNAs; C522604:Mirn16 microRNA, mouse; C556275:Mirn503 microRNA, mouse