title: [Preclinical study as a basis for hygienic regulation of benzofuran derivatives].
abstract: Experiments on laboratory animals studied toxic effects of benzofuran derivatives obtained during anti-arrythmic drug Amiodarone production. Toxic effects were studied for single and subacute intake through intragastric, inhalation and epicutaneous routes. Recommendations are given for hygienic regulation of Amiodarone and intermediate products of its synthesis in the air of workplace.
authors.forename: L G
authors.initials: LG
authors.lastname: Gorokhova
authors.forename: L M
authors.initials: LM
authors.lastname: Sosedova
authors.forename: N A
authors.initials: NA
authors.lastname: Martynova
mesh_terms: D000395:Air Pollutants, Occupational / Q000145:classification / Q000633:toxicity; D000638:Amiodarone / Q000145:classification / Q000633:toxicity; D000818:Animals; D004285:Dogs; D004345:Drug Industry / Q000331:legislation & jurisprudence / Q000592:standards; D033161:Government Regulation; D006168:Guinea Pigs; D007928:Lethal Dose 50; D051379:Mice; D016272:Occupational Health / Q000331:legislation & jurisprudence*; D011817:Rabbits; D051381:Rats; D012426:Russia; D013045:Species Specificity
chemical_list: D000395:Air Pollutants, Occupational; D000638:Amiodarone