title: Efficacy of fluconazole and nystatin in the treatment of vaginal Candida species.
abstract: The aim of this study was to determine and compare the efficacy of treatment with fluconazole and nystatin in Brazilian women with vaginal Candida. In a population of 932 women, vaginal cultures were performed for yeasts, whether or not the women showed signs and symptoms of vulvovaginal candidiasis. Yeasts were isolated from 12.2% of the women (114/932): 53.2% of the yeasts were Candida albicans, 27.0% C. glabrata, 13.5% C. tropicalis and 6.3% C. parapsilosis. Treatment was carried out with both drugs. The overall mean cure rates with fluconazole (87.0%) and nystatin (74.0%) were similar; among women with non-albicans, the cure rate with fluconazole was 100%, whereas that with nystatin was 44.4%. The cure rate for women with C. albicans was high with both fluconazole and nystatin; however, for those with non-albicans species the cure rate was excellent with fluconazole and very low with nystatin, differing from the majority of in vitro studies.
authors.affiliation: Clinical Cytology Laboratory, Department of Clinical Analysis and Biomedicine, State University of Maringá, Brazil.
authors.forename: Helen Priscila Rodrigues
authors.initials: HP
authors.lastname: Martins
authors.forename: Mariana Clivati
authors.initials: MC
authors.lastname: da Silva
authors.forename: Luciene Cássia Farias
authors.initials: LC
authors.lastname: Paiva
authors.forename: Terezinha Inez Estivalet
authors.initials: TI
authors.lastname: Svidzinski
authors.forename: Marcia Edilaine Lopes
authors.initials: ME
authors.lastname: Consolaro
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000627:therapeutic use*; D001938:Brazil; D002176:Candida albicans; D041221:Candida glabrata; D041022:Candida tropicalis; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy* / Q000382:microbiology*; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D009761:Nystatin / Q000627:therapeutic use*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D009761:Nystatin; D015725:Fluconazole