title: General evaluation of hepatectomy and hepatocellular carcinoma cases.
abstract: OBJECTIVE
  Although the clinical and histopathological findings of hepatocellular carcinoma are well described, there are few national studies. In this study, we aimed to investigate the relationship between these findings in total or partial hepatectomy specimens in our series.
  
  
  METHODS
  We first collected 190 cases of total or partial hepatectomies performed because of hepatocellular carcinoma, cirrhosis or other disorders from the archives of Pathology. After re-examining the histopathological and clinical features such as age, gender and etiology, the relationship between them and serology results were statistically analyzed using the chi square and Multiple Comparison Tests.
  
  
  RESULTS
  Among 190 cases, there were 168 (88.5%) total and 18 (9.5%) partial hepatectomies and 4 (2%) tumorectomy or metastasectomy cases. After gross and microscopic examination, 170 (89.5%) cases had a diagnosis of cirrhosis, 85 (44.7%) hepatocellular carcinoma, 3 parasitic cyst, 7 metastasis, 1 hepatoblastoma, 1 hepatocellular adenoma, 2 cholangiocarcinoma, 2 Budd Chiari Syndrome, 1 focal nodular hyperplasia, 1 cavernous hemangioma, and 2 acute fulminant hepatitis. Among the hepatocellular carcinoma cases, 53 had Hepatitis B virus, 15 Hepatitis C virus , 3 Hepatitis B virus and Hepatitis C virus, and 3 Hepatitis B virus and Hepatitis delta virus etiology, while 6 were alcoholic and 4 were due to other causes. Among cirrhosis patients, 84 (49.4%) had hepatocellular carcinoma. The male to female ratio of hepatocellular carcinoma cases was 74/11. The mean age was 55 and the median age 56.7.
  
  
  CONCLUSIONS
  The results of this study demonstrated that the most common hepatic disorder was cirrhosis due to Hepatitis B virus in the hepatectomy specimens of our series that mostly consisted of total hepatectomies performed for transplantation where 50% had hepatocellular carcinoma.
authors.affiliation: Department of Pathology, İstanbul Bilim University, Faculty of Medicine, İstanbul, Turkey. nuraybs@gmail.com
authors.forename: Nuray
authors.initials: N
authors.lastname: Başsüllü
authors.forename: Ilknur
authors.initials: I
authors.lastname: Türkmen
authors.forename: Onur
authors.initials: O
authors.lastname: Yaprak
authors.forename: Murat
authors.initials: M
authors.lastname: Dayangaç
authors.forename: Tolga
authors.initials: T
authors.lastname: Demırbaş
authors.forename: Necdet
authors.initials: N
authors.lastname: Güler
authors.forename: Süleyman
authors.initials: S
authors.lastname: Uraz
authors.forename: Murat
authors.initials: M
authors.lastname: Akyildiz
authors.forename: Engin
authors.initials: E
authors.lastname: Cığercıoğullari
authors.forename: Yaman
authors.initials: Y
authors.lastname: Tokat
authors.forename: Yıldıray
authors.initials: Y
authors.lastname: Yüzer
authors.forename: Gülen Bülbül
authors.initials: GB
authors.lastname: Doğusoy
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D005260:Female; D006498:Hepatectomy / Q000706:statistics & numerical data; D006509:Hepatitis B / Q000453:epidemiology / Q000601:surgery; D006801:Humans; D008099:Liver / Q000473:pathology / Q000601:surgery*; D008103:Liver Cirrhosis / Q000453:epidemiology / Q000601:surgery; D008107:Liver Diseases / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D008113:Liver Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult