title: Methodology development and physical organic chemistry: a powerful combination for the advancement of glycochemistry.
abstract: This Perspective outlines work in the Crich group on the diastereoselective synthesis of the so-called difficult classes of glycosidic bond: the 2-deoxy-β-glycopyranosides, the β-mannopyranosides, the α-sialosides, the α-glucopyranosides, and the β-arabinofuranosides with an emphasis on the critical interplay between mechanism and methodology development.
authors.affiliation: Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA. dcrich@chem.wayne.edu
authors.forename: David
authors.initials: D
authors.lastname: Crich
mesh_terms: D001089:Arabinose / Q000031:analogs & derivatives* / Q000737:chemistry; D002625:Chemistry, Organic; D002627:Chemistry, Physical; D003837:Deoxy Sugars / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D003837:Deoxy Sugars; D005960:Glucosides; C431714:arabinofuranose; D001089:Arabinose