title: In vitro activity of the clinical pulmonary surfactant Surfacen® against Leishmania amazonensis.
abstract: Surfacen® is an exogenous natural lung surfactant, composed by phospholipids and hydrophobic proteins, which is applied successfully in Newborn Respiratory Distress Syndrome. In this paper, in vitro activity of Surfacen® against Leishmania amazonensis is described. The product showed activity against the amastigote form found in peritoneal macrophages from BALB/c mice, with an IC50 value of 17.9 ± 3.0 µg/mL; while no toxic effect on host cell was observed up to 200 µg/mL. This is the first report about the antileishmanial activity of Surfacen®.
authors.affiliation: Grupo de Química-Farmacología-Toxicología, Centro Nacional de Sanidad Agropecuaria, Mayabeque, Cuba.
authors.forename: Odalys
authors.initials: O
authors.lastname: Blanco
authors.forename: Yuliannis
authors.initials: Y
authors.lastname: Lugones
authors.forename: Elaine
authors.initials: E
authors.lastname: Díaz
authors.forename: Lianet
authors.initials: L
authors.lastname: Monzote
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D007894:Leishmania mexicana / Q000187:drug effects*; D007928:Lethal Dose 50; D017737:Macrophages, Peritoneal / Q000469:parasitology; D051379:Mice; D008807:Mice, Inbred BALB C; D021261:Parasitic Sensitivity Tests; D010743:Phospholipids / Q000494:pharmacology*; D037661:Pulmonary Surfactant-Associated Proteins / Q000494:pharmacology*; D011663:Pulmonary Surfactants / Q000494:pharmacology
chemical_list: D000981:Antiprotozoal Agents; D010743:Phospholipids; D037661:Pulmonary Surfactant-Associated Proteins; D011663:Pulmonary Surfactants; C569617:surfacen