title: Ethylene-promoted versus ethylene-free enyne metathesis.
abstract: The role of ethylene in promoting metathesis of acetylenic enynes is probed within the context of ring-closing enyne metathesis, using first- and second-generation Grubbs catalysts. Under inert atmosphere, rapid catalyst deactivation is observed by calibrated GC-FID analysis for substrates with minimal propargylic bulk. MALDI-TOF mass spectra reveal a Ru(enyne)(2) derivative that exhibits very low reactivity toward both enyne and ethylene. Under ethylene, formation of this species is suppressed. Enynes with bulky propargylic groups are not susceptible to this catalyst deactivation pathway, even under N(2) atmosphere.
authors.affiliation: Department of Chemistry; Centre for Catalysis Research & Innovation, University of Ottawa, Ottawa, ON, Canada K1N 6N5.
authors.forename: Anne G D
authors.initials: AG
authors.lastname: Grotevendt
authors.forename: Justin A M
authors.initials: JA
authors.lastname: Lummiss
authors.forename: Melanie L
authors.initials: ML
authors.lastname: Mastronardi
authors.forename: Deryn E
authors.initials: DE
authors.lastname: Fogg