title: Enhancing and sustaining AMG 009 dissolution from a matrix tablet via microenvironmental pH modulation and supersaturation.
abstract: The objective of this study was to investigate the combined effect of pH modifiers and nucleation inhibitors on enhancing and sustaining the dissolution of AMG 009 tablet via supersaturation. Several bases and polymers were added as pH modifiers and nucleation inhibitors, respectively, to evaluate their impact on the dissolution of AMG 009 tablets. The results indicate that sodium carbonate, among the bases investigated, enhanced AMG 009 dissolution the most. HPMC E5 LV, among the nucleation inhibitors tested, was the most effective in sustaining AMG 009 supersaturation. The release of AMG 009 went from 4% for tablets which did not contain both sodium carbonate and HPMC E5 LV to 70% for the ones that did, resulting in a 17.5-fold increase in the extent of dissolution. The effect of compression force and disintegrant on the dissolution of tablets were also evaluated. The results indicate that compression force had no effect on AMG 009 release. The addition of disintegrating agents, on the other hand, decreased the dissolution of AMG 009.
authors.affiliation: Formulation Group, Pharmaceutical R&D, Amgen Inc., Thousand Oaks, California 91320, USA. mbi@amgen.com
authors.forename: Mingda
authors.initials: M
authors.lastname: Bi
authors.forename: Ali
authors.initials: A
authors.lastname: Kyad
authors.forename: Y-H
authors.initials: YH
authors.lastname: Kiang
authors.forename: Yuan-Hon
authors.initials: YH
authors.lastname: Kiang
authors.forename: Fernando
authors.initials: F
authors.lastname: Alvarez-Nunez
authors.forename: Francisco
authors.initials: F
authors.lastname: Alvarez
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry*; D002254:Carbonates / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004339:Drug Compounding; D005750:Gastric Juice / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D065347:Hypromellose Derivatives; D007700:Kinetics; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D010648:Phenylacetates / Q000737:chemistry*; D012995:Solubility; D013449:Sulfonamides / Q000737:chemistry*; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: C570879:AMG 009; D000893:Anti-Inflammatory Agents; D002254:Carbonates; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D010648:Phenylacetates; D013449:Sulfonamides; D013607:Tablets; D065347:Hypromellose Derivatives; C005686:sodium carbonate; D008747:Methylcellulose