title: A meta-analysis of the efficacy of quinolone containing otics in comparison to antibiotic-steroid combination drugs in the local treatment of otitis externa.
abstract: BACKGROUND
  The term otitis externa denotes the inflammation of the external auditory canal and can be treated locally in the form of monotherapy or a combination drug.
  
  
  OBJECTIVE
  The aim of the present meta-analysis was to compare the efficacy of an antibiotic-steroid combination drug with that of monotherapy. According to current data, a comparable investigation based on network analysis does not exist.
  
  
  METHODS
  After systematically searching the PubMed, Medline, Medpilot, Web of Science and Embase electronic databases, 12 relevant randomized, controlled, clinical studies were identified involving 2682 evaluable patients with regard to the cure rate and seven publications with 1251 microbiologically assessable patients. The collected data were compared directly and indirectly by means of network analysis.
  
  
  RESULTS
  The direct comparison showed a trend towards the superiority of the monotherapy containing quinolone. The network analysis verified this tendency and demonstrated that pure quinolone drugs can achieve a significantly higher cure rate (OR: 1.29; 95% CI: 1.06-1.57; p = 0.01) and a significantly superior eradication rate (OR: 1.44; 95% CI: 1.03-2.02; p = 0.03) compared to combination drugs not containing quinolone. We found substantial heterogeneity (with I(2) up to 88.7%) between studies, presumably due to treatments applied in varying frequency, thus bearing on compliance and outcome.
  
  
  CONCLUSIONS
  With a level Ia evidence, this investigation validates the clinical benefit of quinolones as compared to classic combination drugs in the local treatment of acute otitis externa.
authors.affiliation: Institute of Medical Statistics, Informatics and Epidemiology, Faculty of Medicine, University of Cologne, Germany. Ralph@Moesges.de
authors.forename: R
authors.initials: R
authors.lastname: Mösges
authors.forename: M
authors.initials: M
authors.lastname: Nematian-Samani
authors.forename: M
authors.initials: M
authors.lastname: Hellmich
authors.forename: K
authors.initials: K
authors.lastname: Shah-Hosseini
mesh_terms: D000208:Acute Disease; D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D004359:Drug Therapy, Combination / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D010032:Otitis Externa / Q000188:drug therapy*; D015363:Quinolones / Q000008:administration & dosage*; D013256:Steroids / Q000008:administration & dosage*
chemical_list: D000900:Anti-Bacterial Agents; D015363:Quinolones; D013256:Steroids