title: Functional colonic obstruction in an adult as a presenting feature of thymoma.
abstract: Functional colonic obstruction is a colonic motility disorder with a number of causes. One cause is myenteric ganglionitis, which may result from paraneoplastic processes. We present the case of a previously healthy 53-year-old man who presented with a week's history of functional colonic obstruction. A transverse loop colostomy failed to resolve his symptoms and he subsequently underwent an extended right hemicolectomy. Histology demonstrated lymphocytic myenteric ganglionitis that was felt to be of paraneoplastic origin. The patient later developed bilateral ptosis and was diagnosed with ocular myasthenia gravis. Further investigation revealed the presence of a thymoma that was resected, resulting in an improvement to his symptoms. We present this case and a review of the literature to illustrate the importance of seeking out a paraneoplastic cause for functional colonic obstruction in adults as early resection of the tumour may help alleviate symptoms and avoid bowel surgery.
authors.affiliation: Bradford Royal Infirmary, Bradford, UK. karan@doctors.org.uk
authors.forename: K
authors.initials: K
authors.lastname: Malhotra
authors.forename: I B
authors.initials: IB
authors.lastname: Georgiades
authors.forename: J
authors.initials: J
authors.lastname: Davies
mesh_terms: D001342:Autonomic Nervous System Diseases / Q000209:etiology; D003112:Colonic Pseudo-Obstruction / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009197:Myenteric Plexus; D009443:Neuritis / Q000209:etiology; D010257:Paraneoplastic Syndromes / Q000150:complications*; D049268:Positron-Emission Tomography; D013945:Thymoma / Q000150:complications*; D013953:Thymus Neoplasms / Q000150:complications*; D014057:Tomography, X-Ray Computed