title: [Subacute infectious endocarditis of unusual etiology: peculiarities of diagnostics and treatment].
abstract: Infectious endocarditis (IE) is an inflammatory disease of cardiac valves and endocardium of different origin. Subacute IE is a specific form of sepsis associated with the presence of the site of infection in the heart responsible for recurrent septicemia, embolism, and progressive changes in the immune system leading to nephritis, vasculitis, synovitis, and polyserositis. This form develops in response to a low-virulent pathogen (e.g.fungi) or as a result of inefficient antibacterial therapy. A patient is described presenting with fibrous body, aortic and mitral valve infection by the alga Prototheca wickerhamii associated with primary (myeloperoxidase) immunodeficiency. Recent data on diagnostics and treatment of subacute IE are presented.
authors.forename: A V
authors.initials: AV
authors.lastname: Vakhliaev
authors.forename: A I
authors.initials: AI
authors.lastname: Katkov
authors.forename: V O
authors.initials: VO
authors.lastname: Katkova
authors.forename: A P
authors.initials: AP
authors.lastname: Nesterov
authors.forename: N A
authors.initials: NA
authors.lastname: Novikova
authors.forename: R S
authors.initials: RS
authors.lastname: Ovchinnikov
authors.forename: V P
authors.initials: VP
authors.lastname: Sedov
authors.forename: A L
authors.initials: AL
authors.lastname: Syrkin
mesh_terms: D000328:Adult; D004696:Endocarditis / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D011525:Prototheca / Q000302:isolation & purification*; D011743:Pyrimidines / Q000627:therapeutic use; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole