title: Association of alpha B-crystallin genotypes with oral cancer susceptibility, survival, and recurrence in Taiwan.
abstract: BACKGROUND
  Alpha B-crystallin (CRYAB) is a protein that functions as "molecular chaperone" in preserving intracellular architecture and cell membrane. Also, CRYAB is highly antiapoptotic. Abnormal CRYAB expression is a prognostic biomarker for oral cancer, while its genomic variations and the association with carcinogenesis have never been studied.
  
  
  RESULTS
  Therefore, we hypothesized that CRYAB single nucleotide polymorphisms may be associated with oral cancer risk. In this hospital-based study, the association of CRYAB A-1215G (rs2228387), C-802G (rs14133) and intron2 (rs2070894) polymorphisms with oral cancer in a Taiwan population was investigated. In total, 496 oral cancer patients and 992 age- and gender-matched healthy controls were genotyped and analyzed. A significantly different frequency distribution was found in CRYAB C-802G genotypes, but not in A-1215G and intron2 genotypes, between the oral cancer and control groups. The CRYAB C-802G G allele conferred an increased risk of oral cancer (P = 1.49×10(-5)). Patients carrying CG/GG at CRYAB C-802G were of lower 5-year survival and higher recurrence rate than those of CC (P<0.05).
  
  
  CONCLUSIONS
  Our results provide the first evidence that the G allele of CRYAB C-802G is correlated with oral cancer risk and this polymorphism may be a useful marker for oral cancer recurrence and survival prediction for clinical reference.
authors.affiliation: Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan. datian@mail.cmuh.org.tw
authors.forename: Da-Tian
authors.initials: DT
authors.lastname: Bau
authors.forename: Chia-Wen
authors.initials: CW
authors.lastname: Tsai
authors.forename: Cheng-Chieh
authors.initials: CC
authors.lastname: Lin
authors.forename: Ru-Yin
authors.initials: RY
authors.lastname: Tsai
authors.forename: Ming-Hsui
authors.initials: MH
authors.lastname: Tsai
mesh_terms: D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D009062:Mouth Neoplasms / Q000453:epidemiology / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D013624:Taiwan / Q000453:epidemiology; D038203:alpha-Crystallin B Chain / Q000235:genetics*
chemical_list: D038203:alpha-Crystallin B Chain