title: Scoring systems in mantle cell lymphoma: a critical point of view.
abstract: A proposal for a scoring system in the diagnosis of chronic lymphoproliferative diseases other than CLL has been recently published in Cytometry Part B. The authors apply this score for deciding whether or not FISH evaluation for the detection of IGH/CCND1 rearrangements must be performed to exclude Mantle Cell Lymphoma (MCL). In their validation series, no MCL scored <3. We have applied their system to our cases of MCL and also to a small series of Marginal Zone lymphomas. In our hands, the scoring system as has been published does not discriminate adequately between both entities. We propose using the negativity of a marker, CD11c, instead of the platelet count to improve the results. However, we believe that given the clinical and prognostic implications of the diagnosis of MCL, scoring systems should be greatly ameliorated prior to their generalized use.
authors.affiliation: Hematology Laboratory, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain. jjunca@iconcologia.net
authors.forename: Jordi
authors.initials: J
authors.lastname: Juncà
authors.forename: Neus
authors.initials: N
authors.lastname: Ruiz-Xivillé
authors.forename: Isabel
authors.initials: I
authors.lastname: Granada
authors.forename: Inés
authors.initials: I
authors.lastname: Rodríguez-Hernández
authors.forename: Josep-Tomàs
authors.initials: JT
authors.lastname: Navarro
authors.forename: José Luis
authors.initials: JL
authors.lastname: Mate
authors.forename: Fuensanta
authors.initials: F
authors.lastname: Millá
mesh_terms: D018941:Antigens, CD19 / Q000032:analysis; D039521:CD11c Antigen / Q000032:analysis*; D018956:CD5 Antigens / Q000032:analysis; D006801:Humans; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D020522:Lymphoma, Mantle-Cell / Q000145:classification* / Q000175:diagnosis* / Q000473:pathology; D012107:Research Design
chemical_list: D018941:Antigens, CD19; D039521:CD11c Antigen; D018956:CD5 Antigens