title: [Rhupus: report of 4 cases].
abstract: We present the clinical and serological characteristics of four patients with rhupus (Simon's definition). The 4 patients with rhupus presented ACR criteria for SLE as well as for RA, ANA positive with titers ranging from 1/80 to 1/5,250, and positive anti-DNA, with the predominance of symmetrical erosive polyarthritis. We found anti-CCP positivity and high titers in 3 of the 4 patients, and positive antiphospholipid antibodies in 2 (anticardiolipin and LA), without manifestation of antiphospholipid syndrome. One patient presented renal affection, and 2 subcutaneous nodules. The 3 patients with RA preceded the manifestations of SLE by an average of 7.7 years. Two patients were refractory to conventional DMAR in combination, requiring biologic and mycophennolate mofetil.
authors.affiliation: Sección de Reumatología, Hospital José M. Cullen, Santa Fe, Argentina.
authors.forename: Emilio Pablo Ignacio
authors.initials: EP
authors.lastname: Benavente
authors.forename: Sergio Oscar
authors.initials: SO
authors.lastname: Paira
mesh_terms: D000328:Adult; D000368:Aged; D017152:Antibodies, Antiphospholipid / Q000097:blood; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000175:diagnosis*; D008875:Middle Aged
chemical_list: D017152:Antibodies, Antiphospholipid