title: The DBA.2 mouse is susceptible to disease following infection with a broad, but limited, range of influenza A and B viruses.
abstract: We assessed the relative susceptibilities to disease of the DBA.2 and C57BL/6 mouse models upon infection with a range of influenza A and B viruses. DBA.2 mice were more susceptible to disease upon inoculation with human H1N1 influenza A virus strains, several swine influenza viruses, and influenza B viruses but were not overtly susceptible to infection with human seasonal H3N2 strains. Hemagglutination inhibition and immunoglobulin isotype profiling indicated that DBA.2 and C57BL/6 mice generate comparable humoral responses upon equivalent 50% mouse lethal dose (MLD(50)) challenges with influenza virus. Our data demonstrate the utility of DBA.2 mice for the elucidation of influenza virus pathogenicity determinants and the testing of influenza vaccines.
authors.affiliation: Department of Microbiology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York 10029, USA.
authors.forename: Natalie
authors.initials: N
authors.lastname: Pica
authors.forename: Arun
authors.initials: A
authors.lastname: Iyer
authors.forename: Irene
authors.initials: I
authors.lastname: Ramos
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Bouvier
authors.forename: Ana
authors.initials: A
authors.lastname: Fernandez-Sesma
authors.forename: Adolfo
authors.initials: A
authors.lastname: García-Sastre
authors.forename: Anice C
authors.initials: AC
authors.lastname: Lowen
authors.forename: Peter
authors.initials: P
authors.lastname: Palese
authors.forename: John
authors.initials: J
authors.lastname: Steel
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D009980:Influenza A virus / Q000472:pathogenicity*; D009981:Influenza B virus / Q000472:pathogenicity*; D007251:Influenza, Human / Q000276:immunology / Q000473:pathology / Q000821:virology; D008168:Lung / Q000276:immunology / Q000473:pathology / Q000821:virology; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000473:pathology / Q000821:virology*; D014779:Virus Replication