title: Complete genome sequences of Mycobacterium tuberculosis strains CCDC5079 and CCDC5080, which belong to the Beijing family.
abstract: Mycobacterium tuberculosis is one of most prevalent pathogens in the world. Drug-resistant strains of this pathogen caused by the excessive use of antibiotics have long posed serious threats to public health worldwide. A broader picture of drug resistance mechanisms at the genomic level can be obtained only with large-scale comparative genomic methodology. Two closely related Beijing family isolates, one resistant to four first-line drugs (CCDC5180) and one sensitive to them (CCDC5079), were completely sequenced. These sequences will serve as valuable references for further drug resistance site identification studies and could be of great importance for developing drugs targeting these sites.
authors.affiliation: National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention/State Key Laboratory for Infectious Disease Prevention and Control, Beijing 102206, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Haijun
authors.initials: H
authors.lastname: Deng
authors.forename: Aizhen
authors.initials: A
authors.lastname: Pan
authors.forename: Lishui
authors.initials: L
authors.lastname: Zhang
authors.forename: Xiuqin
authors.initials: X
authors.lastname: Zhao
authors.forename: Mingxiang
authors.initials: M
authors.lastname: Huang
authors.forename: Bing
authors.initials: B
authors.lastname: Lu
authors.forename: Haiyan
authors.initials: H
authors.lastname: Dong
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Du
authors.forename: Weijun
authors.initials: W
authors.lastname: Chen
authors.forename: KangLin
authors.initials: K
authors.lastname: Wan
mesh_terms: D016680:Genome, Bacterial / Q000235:genetics*; D008969:Molecular Sequence Data; D009169:Mycobacterium tuberculosis / Q000235:genetics*