title: Cytodiagnosis of histoplasmosis: case reports from two patients with variable clinical presentation.
abstract: Histoplasmosis has emerged as an important opportunistic fungal infection in immunocompromised patients. Histoplasma is a dimorphic fungus that primarily involves lung and the environmental reservoir is soil. Although several cases of histoplasmosis have been reported in India but cytological diagnosis was made in a few cases. We are presenting two cases of histoplasmosis diagnosed on fine-needle aspiration cytology. In the first case, pulmonary histoplasmosis was diagnosed on transbronchial needle aspiration of lung in a 41-year-old immunocompetent male, while second case was of disseminated histoplasmosis in 40-year-old immunocompromised female diagnosed on cytology of cervical lymph node. FNAC is a simple, safe, and rapid technique to establish the initial diagnosis, thus promoting early treatment and favorable outcome especially in the immunocompromised patients.
authors.affiliation: Department of Pathology, Pt. B.D Sharma Post Graduate University of Medical Sciences, Rohtak, Haryana, India.
authors.forename: Sunita
authors.initials: S
authors.lastname: Singh
authors.forename: Sonia
authors.initials: S
authors.lastname: Chhabra
authors.forename: Ruchi
authors.initials: R
authors.lastname: Goyal
authors.forename: Shilpa
authors.initials: S
authors.lastname: Garg
mesh_terms: D000328:Adult; D044963:Biopsy, Fine-Needle; D002584:Cervix Uteri / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D005260:Female; D006651:Histocytochemistry; D006658:Histoplasma / Q000502:physiology*; D006660:Histoplasmosis / Q000175:diagnosis* / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D006801:Humans; D016867:Immunocompromised Host; D008172:Lung Diseases, Fungal / Q000175:diagnosis* / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D008198:Lymph Nodes / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D008297:Male