title: What is the frequency of carbohydrate metabolism disorder in CKD?
abstract: OBJECTIVE
  The objective of this paper is to detect the incidence of insulin resistance (IR) in Chronic Kidney disease (CKD) patients and the presence of impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and diabetes mellitus (DM) in patients with/without IR.
  
  
  METHODS
  We enrolled 113 patients with CKD. Biochemical parameters were investigated.
  
  
  RESULTS
  IFG was found 59.3% of patients with CKD. Age (p = 0.012), BMI (p = 0.036), TG (p = 0.008), HbA1c(p = 0.002), hs-CRP (p = 0.015) levels were higher in patients with IFG. According to the results of Oral glucose tolerance test (OGTT), 69% of patients with CKD had a detected carbohydrate metabolism disorder, 9.7% had DM, 59.3% had IGT. In patients with IFG 13.6% had DM, 31.8% IGT, in patients without IFG 4.2% had DM and 29.8% IGT. The mean HOMA-IR and insulin levels were 3.03 ± 1, 97/11.9 ± 7.13. IR was detected 23% of patients with CKD. In patients with IR; FBG (p = 0.003), serum insulin (p = 0.001), TG (p = 0.05) and HbA1c (p = 0.004) levels were elevated. 31.3% of patients with IFG were found to be IR.
  
  
  CONCLUSIONS
  Carbohydrate metabolism disorder and insulin resistance are found in patients with CKD. Most patients with CKD who are elderly, obesity or overweight offer targets for additional risk factors. For these reasons, screening for DM may be recommended.
authors.affiliation: Department of Nephrology, Bagcilar Research and Education Hospital, Instanbul, Turkey. tanerbast@yahoo.com
authors.forename: Taner
authors.initials: T
authors.lastname: Basturk
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Unsal
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis*; D048909:Diabetes Complications / Q000453:epidemiology; D005260:Female; D018149:Glucose Intolerance / Q000150:complications; D044882:Glucose Metabolism Disorders / Q000150:complications*; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D051436:Renal Insufficiency, Chronic / Q000150:complications*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose