title: Highly diastereo- and enantioselective tandem reaction toward functionalized pyrrolidines with multiple stereocenters.
abstract: An efficient asymmetric tandem dual Michael reaction that constructs three contiguous stereocenters in acyclic open-chain systems with very high enantioselectivity and diastereoselectivity has been developed. This protocol provides a reliable and rapid approach for synthesis of chiral pyrrolidines with multiple stereocenters.
authors.affiliation: State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, PR China.
authors.forename: Shengmei
authors.initials: S
authors.lastname: Guo
authors.forename: Yinjun
authors.initials: Y
authors.lastname: Xie
authors.forename: Xinquan
authors.initials: X
authors.lastname: Hu
authors.forename: Hanmin
authors.initials: H
authors.lastname: Huang