title: Therapeutic potential of Brazilian fluoride varnishes: an in vivo study.
abstract: The aim of this study was to assess in vivo the therapeutic effect of three fluoride varnishes available in the Brazilian market on the performance of white spot lesions (WSL). The sample included 36 children aged 7 to 13 years old, with a total of 67 active WSL in permanent anterior teeth. The children were randomly divided into 3 groups, according to fluoride varnish used: FL- Fluorniz (n=24), DUO - Duofluorid XII (n=22) and DF - Durafluor (n=21). Maximum WSL dimensions (mesiodistal and incisogingival) were measured in millimeters by a previously calibrated single examiner using a periodontal probe. WSL were also assessed regarding lesion activity. Initial and final S-OHI (Simplified Oral Hygiene Index) scores were recorded. Pearson's chi-square test revealed no statistically significant differences (p>0.05) in the performance of the varnishes. At the end of the 5th week, FL had 6 active and 18 inactive WSL; DUO had 7 active and 15 inactive WSL; and DL had 6 active and 15 inactive WSL. Taking into account all lesions, there was a 45.7% reduction in WSL dimensions. Paired Student's t-test revealed a statistically significant difference (p<0.05) between the initial size (1.88) and final size (1.02). After four applications, all varnishes obtained similar clinical results.
authors.affiliation: Caruaru Associação of Graduate Education, Caruaru, PE, Brazil.
authors.forename: Marcella Quirino de
authors.initials: MQ
authors.lastname: Almeida
authors.forename: Olívia Ximenes Izidro
authors.initials: OX
authors.lastname: Costa
authors.forename: Jainara Maria Soares
authors.initials: JM
authors.lastname: Ferreira
authors.forename: Valdenice Aparecida de
authors.initials: VA
authors.lastname: Menezes
authors.forename: Rossana Barbosa
authors.initials: RB
authors.lastname: Leal
authors.forename: Fábio Correia
authors.initials: FC
authors.lastname: Sampaio
mesh_terms: D000293:Adolescent; D018441:Biofilms; D001938:Brazil; D002327:Cariostatic Agents / Q000627:therapeutic use*; D002648:Child; D004396:Coloring Agents; D003731:Dental Caries / Q000145:classification / Q000517:prevention & control*; D003732:Dental Caries Activity Tests; D003774:Dental Plaque Index; D003802:Dentifrices / Q000627:therapeutic use; D005260:Female; D005460:Fluorides, Topical / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009911:Oral Hygiene Index; D012394:Rosaniline Dyes; D012969:Sodium Fluoride / Q000627:therapeutic use; D014089:Tooth Remineralization / Q000379:methods*; D014099:Toothbrushing
chemical_list: D002327:Cariostatic Agents; D004396:Coloring Agents; D003802:Dentifrices; C526357:Duofluorid-F; D005460:Fluorides, Topical; D012394:Rosaniline Dyes; C023807:sodium fluoride topical preparation; C025485:basic fuchsin; D012969:Sodium Fluoride