title: Neolitsea aciculata essential oil inhibits drug-resistant skin pathogen growth and Propionibacterium acnes-induced inflammatory effects of human monocyte leukemia.
abstract: This study examined the chemical composition of Neolitsea aciculata essential oil (NAE) and its biological activities. NAE was obtained by hydro-distillation of N. aciculata leaves collected in Jeju Island and analyzed by gas chromatography equipped with a mass spectrometer detector. 1-Dodecen-3-yne (12.5%), calarene (11.5%) and elemol (9.5%) were identified as the major components of NAE. The antibacterial and anti-inflammatory activities of NAE against skin pathogens were examined to determine the protective properties against acne vulgaris. NAE exhibited moderate to strong antibacterial activity against drug-susceptible and -resistant Propionibacterium acnes and Staphylococcus epidermidis, which are known as acne-causing bacteria. In addition, NAE reduced the P. acnes-induced secretion of tumor necrosis factor-alpha (TNF-alpha) and interleukin-8 (IL-8) in THP-1 cells, highlighting its anti-inflammatory effects. The DPPH radical scavenging activities of NAE also revealed moderate antioxidant properties (IC50, 21.3 microL/mL). Overall, NAE is an attractive candidate as an ingredient in skin care products.
authors.affiliation: Department Department of Chemistry, Cheju National University, Ara-l-dong, Jeju 690-756, Korea.
authors.forename: Sang Suk
authors.initials: SS
authors.lastname: Kim
authors.forename: Jung Eun
authors.initials: JE
authors.lastname: Kim
authors.forename: Chang-Gu
authors.initials: CG
authors.lastname: Hyun
authors.forename: Nam Ho
authors.initials: NH
authors.lastname: Lee
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry; D045744:Cell Line, Tumor; D006801:Humans; D019770:Lauraceae / Q000737:chemistry*; D009000:Monocytes / Q000187:drug effects; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D010851:Picrates / Q000737:chemistry; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*; D011425:Propionibacterium acnes / Q000187:drug effects*; D013212:Staphylococcus epidermidis / Q000187:drug effects*
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D009822:Oils, Volatile; D010851:Picrates; D010938:Plant Oils; C004931:1,1-diphenyl-2-picrylhydrazyl