title: Challenges to the development of new agents for molecularly defined patient subsets: lessons from BRCA1/2-associated breast cancer.
authors.affiliation: University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Domchek
authors.forename: Gillian
authors.initials: G
authors.lastname: Mitchell
authors.forename: Geoffrey J
authors.initials: GJ
authors.lastname: Lindeman
authors.forename: Nadine M
authors.initials: NM
authors.lastname: Tung
authors.forename: Judith
authors.initials: J
authors.lastname: Balmaña
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Isakoff
authors.forename: Rita
authors.initials: R
authors.lastname: Schmutzler
authors.forename: M William
authors.initials: MW
authors.lastname: Audeh
authors.forename: Niklas
authors.initials: N
authors.lastname: Loman
authors.forename: Clare
authors.initials: C
authors.lastname: Scott
authors.forename: Michael
authors.initials: M
authors.lastname: Friedlander
authors.forename: Bella
authors.initials: B
authors.lastname: Kaufman
authors.forename: Judy E
authors.initials: JE
authors.lastname: Garber
authors.forename: Andrew
authors.initials: A
authors.lastname: Tutt
authors.forename: Mark E
authors.initials: ME
authors.lastname: Robson
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D006801:Humans; D009154:Mutation; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D012107:Research Design
chemical_list: D004791:Enzyme Inhibitors; D000067856:Poly(ADP-ribose) Polymerase Inhibitors