title: [Clinicopathologic and immunohistochemical study of 23 cases of mesenchymal chondrosarcoma].
abstract: OBJECTIVE
  To study the clinicopathologic and immunohistochemical features of mesenchymal chondrosarcoma.
  
  
  METHODS
  The clinical and histologic features of 23 cases of mesenchymal chondrosarcoma were analyzed. Immunohistochemical study was also performed in 14 of the cases.
  
  
  RESULTS
  The age of patients ranged from 12 to 47 years. Fourteen of them occurred in males. Thirteen cases involved the bony skeleton and 5 cases affected the soft tissue. The patients presented with pain and/or swelling. Histologically, the tumor consisted of a mixture of undifferentiated small round cells and hyaline cartilage. Transition between the two components was demonstrated and growth plate-like cartilage was observed. Immunohistochemical study showed that the small round cells were positive for Sox9 (14/14), CD99 (12/14), vimentin (6/14), CD56 (4/14), CD57 (4/14), neuron-specific enolase (3/14) and desmin(1/14). They were negative for Coll-II, S-100 protein, epithelial membrane antigen, pan-cytokeratin, synaptophysin, chromogranin A, CD34 and c-erbB2.
  
  
  CONCLUSIONS
  Mesenchymal chondrosarcoma is a rare malignant tumor. Thorough histologic examination, when coupled with immunohistochemical findings, is helpful in arriving at a correct diagnosis.
authors.affiliation: Department of Pathology, West China Hospital of Sichuan University, Chengdu 610041, China. pzgxy@hotmail.com
authors.forename: Zong-guo
authors.initials: ZG
authors.lastname: Pang
authors.forename: Xing-zhuang
authors.initials: XZ
authors.lastname: He
authors.forename: Lan-yan
authors.initials: LY
authors.lastname: Wu
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.forename: Xiao-yu
authors.initials: XY
authors.lastname: Liu
authors.forename: Dian-ying
authors.initials: DY
authors.lastname: Liao
authors.forename: Feng-yuan
authors.initials: FY
authors.lastname: Li
authors.forename: Xian-liang
authors.initials: XL
authors.lastname: Zhang
mesh_terms: D000071443:12E7 Antigen; D000293:Adolescent; D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002648:Child; D018211:Chondrosarcoma, Mesenchymal / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008479:Mediastinal Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009918:Orbital Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D011859:Radiography; D055758:SOX9 Transcription Factor / Q000378:metabolism*; D014746:Vimentin / Q000378:metabolism; D055815:Young Adult
chemical_list: D000071443:12E7 Antigen; D015703:Antigens, CD; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules; D055758:SOX9 Transcription Factor; C527932:SOX9 protein, human; D014746:Vimentin