title: Cancer vaccines inducing antibody production: more pros than cons.
abstract: To date, passive immunotherapy with monoclonal antibodies is a well-established option in clinical oncology. By contrast, anticancer vaccines are less advanced, with the exception of successfully applied prophylactic vaccines against oncogenic virus infections. The creation of therapeutic vaccines is still a great challenge mostly due to the self-nature of tumor antigens. Therapeutic vaccines may be based on patient-specific material including pulsed effector cells, or tumor-associated antigens and derivatives thereof, such as peptides, mimotopes and nucleic acids. The latter represents a more universal approach, which would set an ideal economic framework resulting in broad patient access. In this article we focus on cancer vaccines for antibody production, in particular mimotope vaccines. The collected evidence suggests that they will open up new treatment options in minimal residual disease and early stage disease.
authors.affiliation: Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. erika.jensen-jarolim@meduniwien.ac.at
authors.forename: Erika
authors.initials: E
authors.lastname: Jensen-Jarolim
authors.forename: Josef
authors.initials: J
authors.lastname: Singer
mesh_terms: D000906:Antibodies / Q000276:immunology*; D000917:Antibody Formation / Q000187:drug effects* / Q000276:immunology; D000918:Antibody Specificity; D000951:Antigens, Neoplasm / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D019496:Cancer Vaccines / Q000008:administration & dosage* / Q000096:biosynthesis / Q000138:chemical synthesis / Q000276:immunology; D002986:Clinical Trials as Topic; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology; D006801:Humans; D007116:Immunization, Passive; D016233:Immunotherapy, Active / Q000379:methods*; D008958:Models, Molecular; D009369:Neoplasms / Q000276:immunology / Q000517:prevention & control* / Q000628:therapy; D057285:Precision Medicine / Q000379:methods*
chemical_list: D000906:Antibodies; D000951:Antigens, Neoplasm; D019496:Cancer Vaccines; D016207:Cytokines