title: Cholestasis as the initial presentation of relapsing polychondritis.
abstract: Relapsing polychondritis is an immune-mediated disease associated with inflammation in cartilaginous structures and other tissues throughout the body, particularly the ears, nose, eyes, joints, and respiratory tract. Although association with other conditions is seen in about one-third of the cases, liver involvement is not usually observed in those patients. We described a case of liver involvement in relapsing polychondritis, presenting with a predominantly cholestatic pattern. Other conditions associated with abnormal liver tests were excluded and the patient showed a prompt response to steroid therapy. We discuss the spectrum of the liver involvement in relapsing and review the literature.
authors.affiliation: Division of Gastroenterology, Federal University of Santa Catarina, Florianópolis, Brazil.
authors.forename: Maria
authors.initials: M
authors.lastname: da Graça Ferronato
authors.forename: Leonardo Jönck
authors.initials: LJ
authors.lastname: Staub
authors.forename: Renata Cristina
authors.initials: RC
authors.lastname: Teixeira Pinto Viana
authors.forename: Lígia
authors.initials: L
authors.lastname: da Rosa
authors.forename: Maria Beatriz
authors.initials: MB
authors.lastname: Cacese Shiozawa
authors.forename: Janaína L
authors.initials: JL
authors.lastname: Narciso-Schiavon
authors.forename: Esther Buzaglo
authors.initials: EB
authors.lastname: Dantas-Correa
authors.forename: Leonardo
authors.initials: L
authors.lastname: de Lucca Schiavon
mesh_terms: D001706:Biopsy; D002779:Cholestasis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D011081:Polychondritis, Relapsing / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D013256:Steroids / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D013256:Steroids