title: Distal pancreatectomy with or without splenectomy: comparison of postoperative outcomes and surrogates of splenic function.
abstract: OBJECTIVE
  Published data on splenic preservation during distal pancreatectomy have been inconsistent. We hypothesized that patients undergoing spleen-preserving distal pancreatectomy (SPDP) would have fewer infectious and non-infectious complications than those undergoing en bloc distal pancreatectomy with splenectomy (DPS), and that their haematological parameters would be consistent with splenic function.
  
  
  METHODS
  Of 97 patients who underwent either SPDP using the Warshaw technique or en bloc DPS, 78 met our study inclusion criteria. Records were reviewed for data on age, gender, resection, indications for resection, operative time, blood loss, transfusion requirements, hospital stay, infectious complications, any other complications, postoperative white blood cell (WBC) and platelet counts. Data were analysed using the chi-squared test, the two-sided Mann-Whitney-Wilcoxon text, and simple and multiple logistic regression analyses. A P-value of <0.05 was considered significant.
  
  
  RESULTS
  Patients undergoing SPDP had a shorter length of stay and shorter operative time, were more likely to be completed laparoscopically, less likely to require re-operation, and had fewer infectious and non-infectious complications. However, these differences were not statistically significant. In multiple logistic regression analyses, patient age and length of hospital stay were both significant predictors of the occurrence of non-infectious complications (P= 0.04 and P= 0.006, respectively). Blood transfusion was a significant predictor of postoperative morbidity (P= 0.013 for infectious complications; P= 0.018 for non-infectious complications). White blood cell count was a statistically significant predictor of infectious (P= 0.02) and non-infectious (P= 0.04) complications, whereas platelet count was not. Patients who underwent DPS had statistically significantly higher WBC and platelet counts immediately postoperatively and at 6 months compared with SPDP patients. Postoperative mortality in both the SPDP and DPS groups was 0%. None of the 30 SPDP patients had evidence of splenic infarction. Pancreatic leaks occurred in 18% of patients in the SPDP group, compared with 8% in the DPS group (P < 0.05).
  
  
  CONCLUSIONS
  Spleen-preserving distal pancreatectomy using the Warshaw technique is associated with lower postoperative morbidity than DPS. Lower WBC and platelet counts suggest better splenic function in SPDP patients.
authors.affiliation: Department of General Surgery, Henry Ford Hospital, Detroit, MI, USA.
authors.forename: Athanasios
authors.initials: A
authors.lastname: Tsiouris
authors.forename: Chad M
authors.initials: CM
authors.lastname: Cogan
authors.forename: Vic
authors.initials: V
authors.lastname: Velanovich
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007902:Length of Stay; D007958:Leukocyte Count; D016015:Logistic Models; D008297:Male; D008824:Michigan; D008875:Middle Aged; D016017:Odds Ratio; D010180:Pancreatectomy / Q000009:adverse effects; D010976:Platelet Count; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control; D012086:Reoperation; D018570:Risk Assessment; D012307:Risk Factors; D013154:Spleen / Q000503:physiopathology / Q000601:surgery*; D013156:Splenectomy / Q000009:adverse effects; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult