title: Biological functions of the WAP domain-containing multidomain proteins WFIKKN1 and WFIKKN2.
abstract: WFIKKN1 and WFIKKN2 are two closely related multidomain proteins consisting of a WAP (whey acidic protein)-, a follistatin-, an immunoglobulin-, two Kunitz-type protease inhibitor-domains and an NTR domain (netrin domain). Recent experiments have shown that both WFIKKN1 and WFIKKN2 bind myostatin and GDF11 (growth and differentiation factor 11) with high affinity and are potent antagonists of these growth factors. Structure-function studies on WFIKKN proteins have revealed that their interactions with GDF8 and GDF11 are mediated primarily by the follistatin and NTR domains.
authors.affiliation: Institute of Enzymology, Hungarian Academy of Sciences, H-1113 Budapest, Hungary.
authors.forename: Katalin
authors.initials: K
authors.lastname: Kondás
authors.forename: György
authors.initials: G
authors.lastname: Szláma
authors.forename: Alinda
authors.initials: A
authors.lastname: Nagy
authors.forename: Mária
authors.initials: M
authors.lastname: Trexler
authors.forename: László
authors.initials: L
authors.lastname: Patthy
mesh_terms: D000818:Animals; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008894:Milk Proteins / Q000737:chemistry*; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D014357:Trypsin / Q000378:metabolism; D014361:Trypsin Inhibitors / Q000737:chemistry / Q000378:metabolism
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D008894:Milk Proteins; D011506:Proteins; D014361:Trypsin Inhibitors; C424444:WFIKKN2 protein, human; C024471:whey acidic proteins; D014357:Trypsin