title: [Change of coagulation functions and its significance in acute exacerbation of chronic obstructive pulmonary disease].
abstract: OBJECTIVE
  To explore the changes and clinical significances of plasma D-dimer, factor X and tissue factor in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and analyze the in-depth changes of these indicators in AECOPD with co-current deep venous thrombosis (DVT).
  
  
  METHODS
  A total of 56 AECOPD patients were divided into the DVT and non-DVT subgroups (n = 28 each). And 60 normal control subjects were recruited according to age and gender. For each subject, 2.7 ml whole blood was drawn and then the plasma levels of D-dimer, factor X and tissue factor were detected. The results were statistically analyzed with the software SPSS 13.0. And the analysis of variance was performed between the groups.
  
  
  RESULTS
  There was no significant difference between the distribution of the AECOPD group and the control group by gender and age. Therefore two groups were comparable. And in the AECOPD group, there was no significant difference between the distribution of DVT and non-DVT subgroups by gender and age. Therefore these two subgroups were comparable as well. The value of D-dimer in the AECOPD patients was significantly higher than that in the normal control [(0.76 ± 0.30) vs (0.29 ± 0.11) mg/L, P < 0.01]; and in the AECOPD group, the value of D-dimer in the DVT subgroup was significantly higher than that in the non-DVT subgroup [(0.85 ± 0.29) vs (0.67 ± 0.28) mg/L, P < 0.05]. In the AECOPD group, the value of tissue factor was (238 ± 68) mg/L and the value of factor X (1181 ± 337) mg/L. While in the normal control group, the values were (124 ± 30) and (998 ± 260) mg/L respectively. As for tissue factor and factor X, there were significant differences between two groups (all P < 0.01). Yet in AECOPD patients, neither indicator had significant differences between the DVT and non-DVT subgroups (all P > 0.05).
  
  
  CONCLUSIONS
  The blood of AECOPD patients is in a hypercoagulatory state. And an obvious rise in their plasma level of D-dimer suggests that it may be complicated with DVT.
authors.affiliation: Beijing Institute of Respiratory Medicine, Capital Medical University, Beijing 100020, China.
authors.forename: Xiu-xia
authors.initials: XX
authors.lastname: Huang
authors.forename: Bao-sen
authors.initials: BS
authors.lastname: Pang
authors.forename: Yuan-hua
authors.initials: YH
authors.lastname: Yang
authors.forename: Hai-yan
authors.initials: HY
authors.lastname: Zhang
authors.forename: Su-liang
authors.initials: SL
authors.lastname: Guo
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D001777:Blood Coagulation; D016022:Case-Control Studies; D005170:Factor X / Q000378:metabolism; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000150:complications* / Q000503:physiopathology*; D013925:Thromboplastin / Q000378:metabolism; D020246:Venous Thrombosis / Q000209:etiology
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D005170:Factor X; D013925:Thromboplastin