title: A placental chorionic villous mesenchymal core cellular origin for infantile haemangioma.
abstract: OBJECTIVE
  To investigate the expression of the placental cell-specific associated proteins in infantile haemangioma (IH).
  
  
  METHODS
  Immunohistochemical staining was used to investigate the expression of human chorionic gonadotrophin (hCG), human placental lactogen (hPL), human leucocyte antigen-G (HLA-G), cytokeratin 7 (CK7) and smooth muscle actin in paraffin-embedded sections of proliferating and involuted IHs.
  
  
  RESULTS
  The proteins hCG and hPL were expressed by the endothelium but not the pericyte layer of proliferating IH, but these proteins were not detected in involuted lesions. There was no expression of CK7 and HLA-G in IH.
  
  
  CONCLUSIONS
  The expression of hCG and hPL, but not CK7 or HLA-G, by the endothelium of proliferating IH supports a placental chorionic villous mesenchymal core cellular origin for IH rather than a trophoblast origin.
authors.affiliation: School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand.
authors.forename: Tinte
authors.initials: T
authors.lastname: Itinteang
authors.forename: Swee T
authors.initials: ST
authors.lastname: Tan
authors.forename: Siobhan
authors.initials: S
authors.lastname: Guthrie
authors.forename: Cherise E S
authors.initials: CE
authors.lastname: Tan
authors.forename: Ben C
authors.initials: BC
authors.lastname: McIntyre
authors.forename: Helen D
authors.initials: HD
authors.lastname: Brasch
authors.forename: Darren J
authors.initials: DJ
authors.lastname: Day
mesh_terms: D000199:Actins / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D019070:Cell Lineage; D049109:Cell Proliferation; D002648:Child; D006063:Chorionic Gonadotropin / Q000032:analysis; D002824:Chorionic Villi / Q000737:chemistry / Q000473:pathology*; D042783:Endothelial Cells / Q000737:chemistry / Q000473:pathology; D006680:HLA Antigens / Q000032:analysis; D059951:HLA-G Antigens; D018324:Hemangioma, Capillary / Q000737:chemistry / Q000151:congenital* / Q000473:pathology; D015395:Histocompatibility Antigens Class I / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D053552:Keratin-7 / Q000032:analysis; D008648:Mesoderm / Q000737:chemistry / Q000473:pathology*; D009386:Neoplastic Syndromes, Hereditary; D009520:New Zealand; D010928:Placental Lactogen / Q000032:analysis
chemical_list: C541116:ACTA2 protein, human; D000199:Actins; D014408:Biomarkers, Tumor; D006063:Chorionic Gonadotropin; D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; C507497:KRT7 protein, human; D053552:Keratin-7; D010928:Placental Lactogen