title: Severe jaundice due to coexistence of Dubin-Johnson syndrome and hereditary spherocytosis: a case report.
abstract: Dubin-Johnson syndrome is a chronic, benign, intermittent jaundice, mostly of conjugated hyperbilirubinemia. The level of bilirubin is not expected to be more than 20 mg/dl in this syndrome. In this article, we report a patient who was evaluated for hyperbilirubinemia and liver function test abnormalities and diagnosed with Dubin-Johnson syndrome coexisting with hereditary spherocytosis. We suggest that other diseases should be investigated if patients with Dubin-Johnson syndrome present with severe hyperbilirubinemia. Dubin-Johnson syndrome accompanied by hemolytic diseases might also have high coproporphyrin levels (as in Rotor's syndrome) than expected in pure Dubin-Johnson syndrome.
authors.affiliation: Kocaeli University Medical Faculty, Department of Gastroenterology, Kocaeli, Turkey. drkorkmazugur@yahoo.com
authors.forename: Uğur
authors.initials: U
authors.lastname: Korkmaz
authors.forename: Ali Erkan
authors.initials: AE
authors.lastname: Duman
authors.forename: Deniz
authors.initials: D
authors.lastname: Oğütmen Koç
authors.forename: Yeşim
authors.initials: Y
authors.lastname: Gürbüz
authors.forename: Gökhan
authors.initials: G
authors.lastname: Dındar
authors.forename: Fatih
authors.initials: F
authors.lastname: Ensaroğlu
authors.forename: Selçuk Yusuf
authors.initials: SY
authors.lastname: Sener
authors.forename: Omer
authors.initials: O
authors.lastname: Sentürk
authors.forename: Sadettin
authors.initials: S
authors.lastname: Hülagü
mesh_terms: D001706:Biopsy; D006801:Humans; D006932:Hyperbilirubinemia / Q000209:etiology; D007565:Jaundice / Q000097:blood / Q000209:etiology* / Q000473:pathology; D007566:Jaundice, Chronic Idiopathic / Q000097:blood / Q000150:complications* / Q000473:pathology; D008107:Liver Diseases / Q000209:etiology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000097:blood / Q000150:complications* / Q000628:therapy; D013103:Spherocytosis, Hereditary / Q000097:blood / Q000150:complications* / Q000473:pathology; D013183:Sputum / Q000166:cytology