title: What is the site of origin of cochleovestibular schwannomas?
abstract: The belief that cochleovestibular schwannomas arise from the glial-Schwann cell junction has repeatedly been quoted in the literature, although there is no published evidence that supports this statement. A systematic evaluation of the nerve of origin and the precise location of cochleovestibular schwannomas using our respective archival temporal bone collections was conducted. Forty tumors were within the internal auditory canal (IAC), while 10 were intralabyrinthine neoplasms. Of the 40 IAC schwannomas, 4 arose from the cochlear nerve, and 36 from the vestibular nerve. Twenty-one tumors clearly arose lateral to the glial-Schwann cell junction, while 16 tumors filled at least two thirds of the IAC, with the epicenter of the neoplasm located in the mid part or the lateral part of the IAC. Only 3 schwannomas were located in the medial one third of the IAC in the area of the glial-Schwann cell junction. We concluded that cochleovestibular schwannomas may arise anywhere along the course of the axons of the eighth cranial nerve from the glial-Schwann sheath junction up until their terminations within the auditory and vestibular end organs.
authors.affiliation: Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA. christof_roosli @ meei.harvard.edu
authors.forename: Christof
authors.initials: C
authors.lastname: Roosli
authors.forename: Fred H
authors.initials: FH
authors.lastname: Linthicum
authors.forename: Sebahattin
authors.initials: S
authors.lastname: Cureoglu
authors.forename: Saumil N
authors.initials: SN
authors.lastname: Merchant
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003056:Cochlear Nerve / Q000473:pathology*; D005260:Female; D006801:Humans; D007365:Intercellular Junctions / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009457:Neuroglia / Q000473:pathology*; D009464:Neuroma, Acoustic / Q000473:pathology*; D012583:Schwann Cells / Q000473:pathology*; D013701:Temporal Bone / Q000473:pathology; D014725:Vestibular Nerve / Q000473:pathology*; D014722:Vestibule, Labyrinth / Q000473:pathology*