title: A novel degraded sesquiterpene from the fresh stem of Aquilaria sinensis.
abstract: A novel degraded sesquiterpene, named aquilarin B (1), together with two known compounds (2 and 3), was isolated from the EtOH extract of the fresh stem of Aquilaria sinensis (Lour.) Gilg. Their structures were elucidated by spectroscopic methods including 1D and 2D NMR (HMQC, (1)H-(1)H COSY, HMBC, and ROESY). The cytotoxic activities of the three compounds against three human tumor cell lines K562, SMMC-7721, and SGC-7901 were evaluated, and compound 3 exhibited obvious cytotoxic activity.
authors.affiliation: National Center of Important Tropical Crops Engineering and Technology Research, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Peng
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Mei
authors.forename: You-Xing
authors.initials: YX
authors.lastname: Zhao
authors.forename: Le-He
authors.initials: LH
authors.lastname: Tan
authors.forename: Qing-Huang
authors.initials: QH
authors.lastname: Wang
authors.forename: Hao-Fu
authors.initials: HF
authors.lastname: Dai
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020014:K562 Cells; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029645:Thymelaeaceae / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes; C568248:aquilarin B