title: Pulmonary embolism: predicting disease severity.
abstract: Pulmonary embolism (PE) is the most common cause of acute pulmonary hypertension, yet it is commonly undiagnosed, with risk of death if not recognized promptly and managed accordingly. Patients typically present with hypoxemia and hypomania, although the presentation varies greatly, being confounded by co-morbidities such as pre-existing cardio-respiratory disease. Previous studies have demonstrated variable patient outcomes in spite of similar extent and distribution of pulmonary vascular occlusion, but the path physiological determinants of outcome remain unclear. Computational models enable exact control over many of the compounding factors leading to functional outcomes and therefore provide a useful tool to understand and assess these mechanisms. We review the current state of pulmonary blood flow models. We present a pilot study within 10 patients presenting with acute PE, where patient-derived vascular occlusions are imposed onto an existing model of the pulmonary circulation enabling predictions of resultant haemodynamic after embolus occlusion. Results show that mechanical obstruction alone is not sufficient to cause pulmonary arterial hypertension, even when up to 65 per cent of lung tissue is occluded. Blood flow is found to preferentially redistribute to the gravitationally non-dependent regions. The presence of an additional downstream occlusion is found to significantly increase pressures.
authors.affiliation: Department of Computer Science, University of Oxford, Wolfson Building, Parks Road, Oxford, OX1 3QD, UK. kelly.burrowes@cs.ox.ac.uk
authors.forename: K S
authors.initials: KS
authors.lastname: Burrowes
authors.forename: A R
authors.initials: AR
authors.lastname: Clark
authors.forename: A
authors.initials: A
authors.lastname: Marcinkowski
authors.forename: M L
authors.initials: ML
authors.lastname: Wilsher
authors.forename: D G
authors.initials: DG
authors.lastname: Milne
authors.forename: M H
authors.initials: MH
authors.lastname: Tawhai
mesh_terms: D000465:Algorithms; D001783:Blood Flow Velocity; D015897:Comorbidity; D019295:Computational Biology / Q000379:methods; D003198:Computer Simulation; D006801:Humans; D008168:Lung / Q000098:blood supply* / Q000503:physiopathology; D008953:Models, Anatomic; D010865:Pilot Projects; D011652:Pulmonary Circulation; D011655:Pulmonary Embolism / Q000175:diagnosis* / Q000503:physiopathology; D012039:Regional Blood Flow; D012306:Risk