title: [Coronary disease extension determines mobilization of endothelial progenitor cells and cytokines after a first myocardial infarction with ST elevation].
abstract: OBJECTIVE
  Multivessel coronary disease is still a postinfarction prognostic marker despite new forms of reperfusion, such as primary angioplasty. The aim of this study was to determine the time sequence of various sets of endothelial progenitor cells and angiogenic cytokines (vascular endothelial growth factor, hepatocyte growth factor) according to the degree of extension of the postinfarction coronary disease.
  
  
  METHODS
  We studied the release kinetics in 32 patients admitted for a first myocardial infarction with ST elevation, grouped according to whether they had single or multivessel disease, and 26 controls.
  
  
  RESULTS
  The patients had a higher number of endothelial progenitor cells and angiogenic cytokines than the controls at all 3 measurements (admission, day 3, and day 7) of the following subsets: CD34, CD34+CD133+, CD34+KDR+, and CD34+CD133+KDR+CD45+(weak); this latter was higher on day 7. The levels of these cell subsets were all higher in the patients with single-vessel disease and at all 3 measurements. The vascular endothelial growth factor levels were raised during the first week and the hepatocyte growth factor showed an early peak on admission for infarction. No significant differences were seen in the cytokines according to coronary disease extension.
  
  
  CONCLUSIONS
  Although the release kinetics of different subsets of endothelial progenitor cells in patients with a first acute myocardial infarction with ST elevation was similar in those with single vessel disease to those with multivessel disease, the number of circulating endothelial progenitor cells was greater in the patients with single vessel disease. The vascular endothelial growth factor levels were raised during the first postinfarction week and the hepatocyte growth factor were higher on admission.
authors.affiliation: Área del Corazón, Hospital Clínico Universitario Virgen de la Victoria, Málaga, España. jimeneznavarro@secardiologia.es
authors.forename: Manuel F
authors.initials: MF
authors.lastname: Jiménez-Navarro
authors.forename: Francisco Jesús
authors.initials: FJ
authors.lastname: González
authors.forename: Juan
authors.initials: J
authors.lastname: Caballero-Borrego
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Marchal
authors.forename: Noela
authors.initials: N
authors.lastname: Rodríguez-Losada
authors.forename: Esmeralda
authors.initials: E
authors.lastname: Carrillo
authors.forename: José Manuel
authors.initials: JM
authors.lastname: García-Pinilla
authors.forename: José M
authors.initials: JM
authors.lastname: Hernández-García
authors.forename: Rita
authors.initials: R
authors.lastname: Pérez-González
authors.forename: Gemma
authors.initials: G
authors.lastname: Ramírez
authors.forename: Antonia
authors.initials: A
authors.lastname: Aránega
authors.forename: Eduardo
authors.initials: E
authors.lastname: de Teresa Galván
mesh_terms: D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000378:metabolism; D002452:Cell Count; D002469:Cell Separation; D002637:Chest Pain / Q000209:etiology; D003327:Coronary Disease / Q000150:complications / Q000473:pathology* / Q000628:therapy; D016207:Cytokines / Q000378:metabolism*; D004562:Electrocardiography; D042783:Endothelial Cells / Q000502:physiology*; D005260:Female; D019650:Hematopoietic Stem Cell Mobilization; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D017228:Hepatocyte Growth Factor / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology / Q000502:physiology; D009203:Myocardial Infarction / Q000473:pathology* / Q000628:therapy; D010641:Phenotype; D011379:Prognosis; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D018952:Antigens, CD34; D016207:Cytokines; D042461:Vascular Endothelial Growth Factor A; D017228:Hepatocyte Growth Factor