title: Single nucleotide polymorphism in hsa-mir-196a-2 and breast cancer risk: a case control study.
abstract: microRNAs are small, non-coding RNAs that influence gene expression on a post-transcriptional level. They participate in diverse biological pathways and may act as either tumor suppressor genes or oncogenes. As they may have an effect on thousands of target mRNAs, single-nucleotide polymorphisms in microRNA genes might have major functional consequences, because the microRNA's properties and/or maturation may change. miR-196a has been reported to be aberrantly expressed in breast cancer tissue. Additionally, the SNP rs11614913 in hsa-mir-196a-2 has been found to be associated with breast cancer risk in some studies although not in others. This study evaluated the association between rs11614913 and breast cancer risk in a Caucasian case-control cohort in Queensland, Australia. Results do not support an association of the tested hsa-mir-196a-2 polymorphism with breast cancer susceptibility in this cohort. As there is a discrepancy between our results and previous findings, it is important to assess the role of rs11614913 in breast cancer by further larger studies investigating different ethnic groups.
authors.affiliation: Griffith Health Institute, Griffith University Gold Coast, Southport, Australia.
authors.forename: Dominik J
authors.initials: DJ
authors.lastname: Jedlinski
authors.forename: Plamena N
authors.initials: PN
authors.lastname: Gabrovska
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Weinstein
authors.forename: Robert A
authors.initials: RA
authors.lastname: Smith
authors.forename: Lyn R
authors.initials: LR
authors.lastname: Griffiths
mesh_terms: D001315:Australia; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D015331:Cohort Studies; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
chemical_list: D004273:DNA, Neoplasm; C542543:MIRN196 microRNA, human; D035683:MicroRNAs