title: Trypanosoma cruzi connatal transmission in dogs with Chagas disease: experimental case report.
abstract: Trypanosoma cruzi connatal transmission was studied in male and female mongrel dogs. Both dogs were experimentally infected, after which on the 20(th) day, lymphoadenomegaly and fever were found. Four months postinfection, they mated. At this time, Chagas disease was confirmed by two different diagnostic tests. The electrocardiogram and echocardiogram taken at the eight postinoculation month showed data consistent with ischemia, local conduction abnormalities and hypertrophy, as well as a diminished ejection fraction and left ventricular dilation, respectively. Four puppies were born and after weaning had weakness, progressive weight loss, and chronic diarrhea. Necropsy of all four showed digestive alterations and cardiac dilation. Serology in the offspring was positive for Chagas disease. The histopathological study demonstrated a cardiac chronic inflammatory process, although no parasites were found. Clinical data and serological determinations are consistent with death from advanced Chagas disease.
authors.affiliation: Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Olivia
authors.initials: O
authors.lastname: Rodríguez-Morales
authors.forename: Martha A
authors.initials: MA
authors.lastname: Ballinas-Verdugo
authors.forename: Ricardo
authors.initials: R
authors.lastname: Alejandre-Aguilar
authors.forename: Pedro A
authors.initials: PA
authors.lastname: Reyes
authors.forename: Minerva
authors.initials: M
authors.lastname: Arce-Fonseca
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood*; D006332:Cardiomegaly; D014355:Chagas Disease / Q000151:congenital / Q000469:parasitology / Q000635:transmission / Q000662:veterinary*; D004285:Dogs; D004452:Echocardiography / Q000662:veterinary; D004562:Electrocardiography / Q000662:veterinary; D017809:Fatal Outcome; D005260:Female; D005334:Fever; D005455:Fluorescent Antibody Technique / Q000662:veterinary; D018445:Infectious Disease Transmission, Vertical / Q000662:veterinary*; D008206:Lymphatic Diseases / Q000151:congenital / Q000469:parasitology / Q000662:veterinary; D008297:Male; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000469:parasitology / Q000662:veterinary*; D013997:Time Factors; D014349:Trypanosoma cruzi / Q000276:immunology*
chemical_list: D000913:Antibodies, Protozoan