title: Photoinduced DNA cleavage promoted by two copper(II) complexes of tetracyclines and 1,10-phenanthroline.
abstract: In this report, we demonstrate how UV-light exposure can enhance DNA cleavage promoted by two copper(II) complexes of tetracyclines and 1,10-phenanthroline about 40 times in comparison to nonirradiated conditions. In addition, new aspects regarding their DNA binding properties, as well as the mechanism of the cleavage reaction, were also investigated.
authors.affiliation: Centro de Biologia Molecular Estrutural, Departamento de Bioquímica, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina 88040-900, Brazil.
authors.forename: Tiago
authors.initials: T
authors.lastname: Bortolotto
authors.forename: Priscila Pereira
authors.initials: PP
authors.lastname: Silva
authors.forename: Ademir
authors.initials: A
authors.lastname: Neves
authors.forename: Elene Cristina
authors.initials: EC
authors.lastname: Pereira-Maia
authors.forename: Hernán
authors.initials: H
authors.lastname: Terenzi
mesh_terms: D000818:Animals; D003300:Copper / Q000737:chemistry / Q000378:metabolism; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D053837:DNA Cleavage / Q000187:drug effects* / Q000528:radiation effects; D006801:Humans; D007364:Intercalating Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D009369:Neoplasms / Q000188:drug therapy; D009942:Organometallic Compounds / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D010618:Phenanthrolines / Q000737:chemistry* / Q000378:metabolism; D055668:Photochemical Processes / Q000187:drug effects / Q000528:radiation effects; D010778:Photochemotherapy / Q000379:methods; D017319:Photosensitizing Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D010957:Plasmids / Q000737:chemistry / Q000378:metabolism; D013754:Tetracyclines / Q000737:chemistry* / Q000378:metabolism; D014466:Ultraviolet Rays
chemical_list: D007364:Intercalating Agents; D009942:Organometallic Compounds; D010618:Phenanthrolines; D017319:Photosensitizing Agents; D013754:Tetracyclines; D003300:Copper; D004247:DNA; C025205:1,10-phenanthroline