title: Carbamazepine differentially affects the pharmacokinetics of fexofenadine enantiomers.
abstract: OBJECTIVE
  This aim of this study was to characterize the impact of the P-glycoprotein (P-gp) inducer, carbamazepine, on fexofenadine enantiomer pharmacokinetics.
  
  
  METHODS
  Twelve healthy volunteers initially received a 60mg dose of fexofenadine alone. Subsequently, a 100mg dose of carbamazepine was administered three times daily (300mg day(-1) ), and on day 7, fexofenadine was co-administered.
  
  
  RESULTS
  Carbamazepine significantly decreased the area under the plasma concentration-time curve and the amount excreted into the urine of (S)- and (R)-fexofenadine. The P-gp inducer showed a greater effect on the pharmacokinetic parameters of (S)-fexofenadine.
  
  
  CONCLUSIONS
  This study indicates that carbamazepine may alter the pharmacokinetics of fexofenadine enantiomers.
authors.affiliation: Department of Hospital Pharmacy, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Akamine
authors.forename: Masatomo
authors.initials: M
authors.lastname: Miura
authors.forename: Norio
authors.initials: N
authors.lastname: Yasui-Furukori
authors.forename: Midori
authors.initials: M
authors.lastname: Kojima
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Uno
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism*; D000328:Adult; D018926:Anti-Allergic Agents / Q000493:pharmacokinetics*; D000927:Anticonvulsants / Q000493:pharmacokinetics*; D019540:Area Under Curve; D044466:Asian People; D002220:Carbamazepine / Q000493:pharmacokinetics*; D004347:Drug Interactions; D006801:Humans; D008297:Male; D013237:Stereoisomerism; D016593:Terfenadine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D055815:Young Adult
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D018926:Anti-Allergic Agents; D000927:Anticonvulsants; D002220:Carbamazepine; D016593:Terfenadine; C093230:fexofenadine