title: Inhibitory effects of Chelidonium majus extract on atopic dermatitis-like skin lesions in NC/Nga mice.
abstract: OBJECTIVE
  Chelidonium majus (CM) has traditionally been used for treatment of various inflammatory diseases including atopic dermatitis (AD). However its action on atopic dermatitis (AD) is unclear. Therefore, we investigated the effect of CM on AD using NC/Nga mice as an AD model.
  
  
  METHODS
  The effect of CM on 1-chloro-2,4-dinitrobenzene (DNCB) induced NC/Nga mice was evaluated by examining skin symptom severity, itching behavior, ear thickness, levels of serum immunoglobulin E (IgE), tumor necrosis factor-α (TNF-α), and interlukin-4 (IL-4), skin histology.
  
  
  RESULTS
  The CM significantly reduced the total clinical severity score, itching behavior, ear thickness and the level of serum IgE in AD mouse model. CM not only decreased TNF-α but also IL-4.
  
  
  CONCLUSIONS
  These results suggest that CM may be a potential therapeutic modality for AD.
authors.affiliation: Department of Herbology, College of Oriental Medicine, Kyung-Hee University, Seoul 130-701, Republic of Korea.
authors.forename: Gabsik
authors.initials: G
authors.lastname: Yang
authors.forename: Kyungjin
authors.initials: K
authors.lastname: Lee
authors.forename: Mi-Hwa
authors.initials: MH
authors.lastname: Lee
authors.forename: So-Hyung
authors.initials: SH
authors.lastname: Kim
authors.forename: In-Hye
authors.initials: IH
authors.lastname: Ham
authors.forename: Ho-Young
authors.initials: HY
authors.lastname: Choi
mesh_terms: D000818:Animals; D028281:Chelidonium / Q000737:chemistry*; D003876:Dermatitis, Atopic / Q000188:drug therapy*; D004137:Dinitrochlorobenzene / Q000633:toxicity; D004195:Disease Models, Animal; D007073:Immunoglobulin E / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D051379:Mice; D010936:Plant Extracts / Q000627:therapeutic use*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D004137:Dinitrochlorobenzene; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D015847:Interleukin-4; D007073:Immunoglobulin E