title: Age-related cerebral perfusion changes in the parietal and temporal lobes measured by pulsed arterial spin labeling.
abstract: OBJECTIVE
  To investigate age-related regional perfusion changes focused on the medial temporal lobes and related parietal areas using a pulsed arterial spin labeling technique.
  
  
  METHODS
  Resting cerebral blood flow (CBF) maps were obtained from 44 healthy volunteers (18 male, 26 female; age range, 19 to 79 years) using a pulsed arterial spin labeling (PASL) MRI technique at 3 Tesla focused on the parietal and temporal lobes. Repeated measurements were performed in 20 subjects to assure the reliability and reproducibility of the applied PASL technique.
  
  
  RESULTS
  Focal age-related CBF decreases were detected in the parietal cortex, cuneus and caudate, whereas increases were seen in the lateral and medial temporal lobe such as hippocampus, the calcarine gyrus and the thalamus. Moreover, repeated measurements demonstrated a high reliability and reproducibility of the applied PASL technique.
  
  
  CONCLUSIONS
  Data provide evidence for regionally dissociated patterns of perfusion increases and decreases during ageing in the temporal and parietal lobes.
authors.affiliation: Department of Neuroradiology, Technische Universität München, Munich, Germany; Department of Neurology, Technische Universität München, München, Germany. preibisch@lrz.tu-muenchen.de
authors.forename: Christine
authors.initials: C
authors.lastname: Preibisch
authors.forename: Christian
authors.initials: C
authors.lastname: Sorg
authors.forename: Annette
authors.initials: A
authors.lastname: Förschler
authors.forename: Timo
authors.initials: T
authors.lastname: Grimmer
authors.forename: Iris
authors.initials: I
authors.lastname: Sax
authors.forename: Afra M
authors.initials: AM
authors.lastname: Wohlschläger
authors.forename: Robert
authors.initials: R
authors.lastname: Perneczky
authors.forename: Hans
authors.initials: H
authors.lastname: Förstl
authors.forename: Alexander
authors.initials: A
authors.lastname: Kurz
authors.forename: Claus
authors.initials: C
authors.lastname: Zimmer
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Alexopoulos
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010296:Parietal Lobe / Q000098:blood supply*; D015203:Reproducibility of Results; D013113:Spin Labels; D013702:Temporal Lobe / Q000098:blood supply*
chemical_list: D013113:Spin Labels