title: [Clinical strategies for prevention of drug-induced urinary calculi].
abstract: Drug-induced urinary calculi, although they account for only 1-2% of urinary calculi, deserve consideration because most of them are preventable. In the drug-containing calculi resulting from the crystallization of a certain drug and its metabolites in the urine, stone analysis can identify the responsible drug. While, in the drug-induced metabolic calculi caused by interference with calcium, oxalate and purine metabolism, careful clinical inquiry is necessary to reveal involvement of a certain drug in stone formation. Better awareness of the possible drugs with lithogenic potential and close surveillance of patients on long-term treatment with these drugs are necessary. Especially, in patients with a history of urolithiaisis, prescription of lithogenic drugs deserve careful consideration.
authors.affiliation: Department of Urology, Wakayama Medical University, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Kohjimoto
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Isao
authors.initials: I
authors.lastname: Hara
mesh_terms: D000493:Allopurinol / Q000009:adverse effects; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001205:Ascorbic Acid / Q000009:adverse effects; D001553:Benzbromarone / Q000009:adverse effects; D002118:Calcium / Q000378:metabolism; D017610:Calcium Compounds / Q000009:adverse effects; D002257:Carbonic Anhydrase Inhibitors / Q000009:adverse effects; D003460:Crystallization; D004232:Diuretics / Q000009:adverse effects*; D004338:Drug Combinations; D005665:Furosemide / Q000009:adverse effects; D005938:Glucocorticoids / Q000009:adverse effects; D006801:Humans; D017633:Magnesium Silicates / Q000009:adverse effects; D010070:Oxalates / Q000378:metabolism; D011480:Protease Inhibitors / Q000009:adverse effects*; D011687:Purines / Q000378:metabolism; D013997:Time Factors; D014223:Triamterene / Q000009:adverse effects*; D014545:Urinary Calculi / Q000139:chemically induced* / Q000737:chemistry / Q000517:prevention & control*; D014807:Vitamin D / Q000009:adverse effects
chemical_list: D000900:Anti-Bacterial Agents; D017610:Calcium Compounds; D002257:Carbonic Anhydrase Inhibitors; D004232:Diuretics; D004338:Drug Combinations; D005938:Glucocorticoids; D017633:Magnesium Silicates; D010070:Oxalates; D011480:Protease Inhibitors; D011687:Purines; C086509:allopurinol, benzbromarone drug combination; C005013:Florisil; D014807:Vitamin D; D001553:Benzbromarone; D000493:Allopurinol; D005665:Furosemide; D001205:Ascorbic Acid; D002118:Calcium; C030985:purine; D014223:Triamterene