title: Renal safety of Non Steroidal Anti Inflammatory Drugs (NSAIDs) in the pharmacologic treatment of patent ductus arteriosus.
abstract: Patent ductus arteriosus (PDA) often complicates the clinical course of neonates born prematurely and increases their short- and long-term morbidity. Treatment of PDA remains an ongoing debate among neonatologists for various issues such as the timing, the criteria and the methods for its closure. Non steroidal anti inflammatory drugs have been used as the standard pharmacological treatment for PDA. Indomethacin was the first one to be used. Its use though, waned due recognition of renal cerebral and gastrointestinal complications associated with the administration of this drug. Ibuprofen has emerged in clinical practice, as it has been reported to have lower nephrotoxicity. This review will examine existing data in the literature on the early- and long-term nephrotoxicity associated with the two drugs and will discuss present and future directions the management and prevention of this condition.
authors.affiliation: Department of Pediatrics and Clinical Medicine, Section of Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, Azienda Mista and University of Cagliari, Cagliari, Italy. vafanos@tiscali.it
authors.forename: Vassilios
authors.initials: V
authors.lastname: Fanos
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: Marcialis
authors.forename: Pier Paolo
authors.initials: PP
authors.lastname: Bassareo
authors.forename: Roberto
authors.initials: R
authors.lastname: Antonucci
authors.forename: Marco
authors.initials: M
authors.lastname: Zaffanello
authors.forename: Angelica
authors.initials: A
authors.lastname: Dessì
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Iacovidou
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology / Q000503:physiopathology / Q000517:prevention & control; D004374:Ductus Arteriosus, Patent / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000453:epidemiology / Q000517:prevention & control; D058958:Organs at Risk / Q000503:physiopathology; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal