title: Rational polytherapy in the treatment of acute seizures and status epilepticus.
abstract: We used a model of severe cholinergic status epilepticus (SE) to study polytherapy aimed at reversing the effects of seizure-induced loss of synaptic GABA(A)  receptors and seizure-induced gain of synaptic NMDA receptors. Combinations of a benzodiazepine with ketamine and valproate, or with ketamine and brivaracetam, were more effective and less toxic than benzodiazepine monotherapy in this model of SE.
authors.affiliation: Epilepsy Research Laboratory, VA Greater Los Angeles Health Care System, 11301 Wilshire Boulevard, West Los Angeles, CA 90073, USA. wasterla@ucla.edu
authors.forename: Claude G
authors.initials: CG
authors.lastname: Wasterlain
authors.forename: Roger
authors.initials: R
authors.lastname: Baldwin
authors.forename: David E
authors.initials: DE
authors.lastname: Naylor
authors.forename: Kerry W
authors.initials: KW
authors.lastname: Thompson
authors.forename: Lucie
authors.initials: L
authors.lastname: Suchomelova
authors.forename: Jerome
authors.initials: J
authors.lastname: Niquet
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination / Q000379:methods*; D006801:Humans; D012640:Seizures / Q000188:drug therapy*; D013226:Status Epilepticus / Q000188:drug therapy*
chemical_list: D000927:Anticonvulsants