title: Dose-dependent pharmacokinetics of tyrosol galactoside as an anti-fatigue drug in rats.
abstract: Tyrosol galactoside (TG) is a new candidate anti-fatigue agent under development. In order to have a good understanding of its pharmacokinetic characters, the paper describes the dose-dependent pharmacokinetics of TG in rats after oral and intravenous administration. TG was rapidly absorbed after oral administration and cleared with first-order rate, for the plasma half-life was independent of dose. C(max) and AUC(0-infinity) after both intravenous and oral dosing were all linearly correlated with the dose, as the regression correlation coefficient (R) was 0.998, 0.989 and 0.994 for AUC(0-infinity) (i.v., P < 0.01) AUC(0-infinity) (i.g., P < 0.01) and C(max) (i. g., P < 0.01), respectively. However, these parameters increased less than proportionally with increasing dose. In addition, the apparent volume of distribution (Vd) and the apparent clearance (Cl) seemed to be affected by the dose.
authors.affiliation: Department of Pharmacology, Fourth Military Medical University, Xi'an, PR China.
authors.forename: Yating
authors.initials: Y
authors.lastname: Deng
authors.forename: Qingwei
authors.initials: Q
authors.lastname: Wang
authors.forename: Xueying
authors.initials: X
authors.lastname: Liu
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Zijie
authors.initials: Z
authors.lastname: Ding
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D005221:Fatigue / Q000188:drug therapy*; D005697:Galactosides / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D007275:Injections, Intravenous; D007408:Intestinal Absorption; D008297:Male; D010626:Phenylethyl Alcohol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D005697:Galactosides; C557337:tyrosol galactoside; D010626:Phenylethyl Alcohol