title: Graphene oxide-protected DNA probes for multiplex microRNA analysis in complex biological samples based on a cyclic enzymatic amplification method.
abstract: Based on graphene oxide-protected DNA probes, we have developed a cyclic enzymatic amplification method for sensitive miRNA detection in complex biological samples. By using the quenching nature of graphene oxide for multiple fluorophores, this method can distinguish highly similar miRNA sequences and detect them simultaneously.
authors.affiliation: The Key Laboratory of Analytical Science, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Cui
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Lin
authors.forename: Ninghang
authors.initials: N
authors.lastname: Lin
authors.forename: Yanling
authors.initials: Y
authors.lastname: Song
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zhu
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.forename: Chaoyong James
authors.initials: CJ
authors.lastname: Yang
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D015342:DNA Probes / Q000737:chemistry*; D003850:Deoxyribonuclease I / Q000378:metabolism; D005456:Fluorescent Dyes / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D035683:MicroRNAs / Q000032:analysis* / Q000378:metabolism; D010087:Oxides / Q000737:chemistry*; D012680:Sensitivity and Specificity
chemical_list: D015342:DNA Probes; D005456:Fluorescent Dyes; D035683:MicroRNAs; D010087:Oxides; D006108:Graphite; D003850:Deoxyribonuclease I