title: [Clinicopathological characteristics of male breast cancer: analysis of 25 cases at a single institution].
abstract: OBJECTIVE
  To investigate general and clinicopathological characteristics of male breast cancer and analyzed the factors affecting the outcomes of the patients based on the data from a single institution.
  
  
  METHODS
  Twenty-five male breast cancer patients treated at Sun Yet-sen University Cancer Center between January 1, 2000 and April 30, 2011 were included into the study. The patients were followed up for 1 to 90 months with a median follow-up of 51 months. The general and clinicopathological characteristics including family history, age, smoking, alcohol drinking, site of tumor, location of tumor, histological type, estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2), Ki-67, vascular endothelial growth factor (VEGF), P53 expression, neoadjuvant chemotherapy, surgery, adjuvant chemotherapy, adjuvant radiotherapy, adjuvant endocrine therapy, tumor size, lymph node status, distant metastasis and TNM stage were investigated by univariate analysis to evaluate the impact of these factors on patient survival.
  
  
  RESULTS
  The 5-year survival rate was 66.5% in these patients. Neoadjuvant chemotherapy, tumor size, lymph node status, distant metastasis and TNM stage were significant predictors for the overall survival. Patients receiving adjuvant endocrine therapy tended to have a better overall survival, though this was not supported statistically (P=0.086). However, patients with neoadjuvant chemotherapy had a poorer overall survival than those without it (P=0.000). Patients in stages I and II had better overall survival than those in stages III and IV (P=0.000).
  
  
  CONCLUSIONS
  The 5-year survival rate was 66.5% in these male breast cancer patients. Neoadjuvant chemotherapy, tumor size, lymph node status, distant metastasis and TNM stage are significant predictors of the overall patient survival.
authors.affiliation: Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China. xiaqing@sysucc.org.cn
authors.forename: Qing
authors.initials: Q
authors.lastname: Xia
authors.forename: Yan-xia
authors.initials: YX
authors.lastname: Shi
authors.forename: Dong-geng
authors.initials: DG
authors.lastname: Liu
authors.forename: Wen-qi
authors.initials: WQ
authors.lastname: Jiang
mesh_terms: D018567:Breast Neoplasms, Male / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate