title: Relapse of polymicrobial endocarditis in an intravenous drug user.
abstract: A 26-year-old male intravenous drug user (IDU) presented twice within 6 months with relapsed polymicrobial infective endocarditis (IE) due to Eikenella corrodens and Streptococcus constellatus after completing two courses of appropriate antimicrobial therapy. This report points to relapsing endocarditis as a clinical entity that warrants attention in IDUs when E. corrodens or S. constellatus are causative agents of IE.
authors.affiliation: Department of Cell Biology, Yale School of Medicine, New Haven, Connecticut 06520, USA.
authors.forename: Ruth W
authors.initials: RW
authors.lastname: Wang'ondu
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Murray
mesh_terms: D000328:Adult; D002443:Ceftriaxone / Q000494:pharmacology; D060085:Coinfection / Q000382:microbiology*; D016124:Eikenella corrodens / Q000302:isolation & purification / Q000472:pathogenicity*; D004697:Endocarditis, Bacterial / Q000382:microbiology*; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000494:pharmacology; D010068:Oxacillin / Q000494:pharmacology; D012008:Recurrence; D013290:Streptococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D034365:Streptococcus constellatus / Q000302:isolation & purification / Q000472:pathogenicity*; D019966:Substance-Related Disorders
chemical_list: D008795:Metronidazole; D002443:Ceftriaxone; D010068:Oxacillin