title: Corpus callosum size and shape alterations in adolescent inhalant users.
abstract: Inhalants, frequently abused during adolescence, are neurotoxic to white matter. We investigated the impact of inhalant misuse on the morphology of the corpus callosum (CC), the largest white matter bundle in the brain, in an adolescent sample of inhalant users [n = 14; mean age = 17.3; standard deviation (SD) = 1.7], cannabis users (n = 11; mean age = 19.7; SD = 1.7) and community controls (n = 9; mean age = 19.5; SD = 2.6). We identified significant morphological differences in the CC among inhalant users compared with community controls. There were no morphological differences between inhalant and cannabis users. Our findings may represent the early stages of neurobiological damage associated with chronic inhalant misuse.
authors.affiliation: Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Takagi
authors.forename: Dan I
authors.initials: DI
authors.lastname: Lubman
authors.forename: Mark
authors.initials: M
authors.lastname: Walterfang
authors.forename: Sarah
authors.initials: S
authors.lastname: Barton
authors.forename: David
authors.initials: D
authors.lastname: Reutens
authors.forename: Amanda
authors.initials: A
authors.lastname: Wood
authors.forename: Murat
authors.initials: M
authors.lastname: Yücel
mesh_terms: D000293:Adolescent; D000367:Age Factors; D016880:Anisotropy; D016022:Case-Control Studies; D003337:Corpus Callosum / Q000187:drug effects / Q000473:pathology*; D056324:Diffusion Tensor Imaging / Q000379:methods; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000473:pathology; D005260:Female; D006801:Humans; D058545:Inhalant Abuse / Q000473:pathology*; D008297:Male; D002189:Marijuana Abuse / Q000473:pathology; D055815:Young Adult