title: Efficacy of diphenhydramine in the prevention of vertigo and nausea at 7 T MRI.
abstract: OBJECTIVE
  In this study the potential of diphenhydramine in reducing respectively preventing vertigo and nausea induced by the ultra-high static magnetic field at 7 T was evaluated.
  
  
  METHODS
  In a prospective, double blinded, placebo controlled, cross-over randomized study the sensations of 34 volunteers before, during and after exposure to the static magnetic field with and without drug respectively placebo administration were quantified. Fast table motion was applied to increase the incidence of otherwise sparse reports of field related sensations.
  
  
  RESULTS
  The strength of vertigo can be reduced by the application of diphenhydramine.
  
  
  CONCLUSIONS
  Diphenhydramine, even at a low dose, reduces the strength of vertigo at ultra-high static magnetic fields, may be used preventively, and could pave the way to even higher field strength.
authors.affiliation: Klinik für Radiologie und Nuklearmedizin, Universitätsklinikum Magdeburg A.ö.R., Otto-von-Guericke Universität, Leipziger Str. 44, 39120 Magdeburg, Germany. markus.thormann@med.ovgu.de
authors.forename: Markus
authors.initials: M
authors.lastname: Thormann
authors.forename: Holger
authors.initials: H
authors.lastname: Amthauer
authors.forename: Daniela
authors.initials: D
authors.lastname: Adolf
authors.forename: Astrid
authors.initials: A
authors.lastname: Wollrab
authors.forename: Jens
authors.initials: J
authors.lastname: Ricke
authors.forename: Oliver
authors.initials: O
authors.lastname: Speck
mesh_terms: D000328:Adult; D004155:Diphenhydramine / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D060526:Magnetic Fields / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control*; D015990:Placebo Effect; D011446:Prospective Studies; D016896:Treatment Outcome; D014717:Vertigo / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control*
chemical_list: D006993:Hypnotics and Sedatives; D004155:Diphenhydramine