title: Frequency-domain optical tomographic imaging of arthritic finger joints.
abstract: We are presenting data from the largest clinical trial on optical tomographic imaging of finger joints to date. Overall we evaluated 99 fingers of patients affected by rheumatoid arthritis (RA) and 120 fingers from healthy volunteers. Using frequency-domain imaging techniques we show that sensitivities and specificities of 0.85 and higher can be achieved in detecting RA. This is accomplished by deriving multiple optical parameters from the optical tomographic images and combining them for the statistical analysis. Parameters derived from the scattering coefficient perform slightly better than absorption derived parameters. Furthermore we found that data obtained at 600 MHz leads to better classification results than data obtained at 0 or 300 MHz.
authors.affiliation: Department of Biomedical Engineering, Columbia University, New York 10027, USA. ahh2004@columbia.edu
authors.forename: Andreas H
authors.initials: AH
authors.lastname: Hielscher
authors.forename: Hyun Keol
authors.initials: HK
authors.lastname: Kim
authors.forename: Ludguier D
authors.initials: LD
authors.lastname: Montejo
authors.forename: Sabine
authors.initials: S
authors.lastname: Blaschke
authors.forename: Uwe J
authors.initials: UJ
authors.lastname: Netz
authors.forename: Paul A
authors.initials: PA
authors.lastname: Zwaka
authors.forename: Gerd
authors.initials: G
authors.lastname: Illing
authors.forename: Gerhard A
authors.initials: GA
authors.lastname: Muller
authors.forename: Jürgen
authors.initials: J
authors.lastname: Beuthan
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D019540:Area Under Curve; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000473:pathology*; D016022:Case-Control Studies; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D005260:Female; D005384:Finger Joint / Q000473:pathology*; D005583:Fourier Analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012680:Sensitivity and Specificity; D041622:Tomography, Optical / Q000379:methods*