title: Selective repression of Notch pathway target gene transcription.
abstract: The Notch signaling pathway regulates metazoan development, in part, by directly controlling the transcription of target genes. For a given cellular context, however, only subsets of the known target genes are transcribed when the pathway is activated. Thus, there are context-dependent mechanisms that selectively maintain repression of target gene transcription when the Notch pathway is activated. This review focuses on molecular mechanisms that have been recently reported to mediate selective repression of Notch pathway target gene transcription. These mechanisms are essential for generating the complex spatial and temporal expression patterns of Notch target genes during development.
authors.affiliation: Dept. of. Neurology and Neuroscience, Weill Cornell Medical College, 785 Mamaroneck Ave., White Plains, NY 10605, USA. joc2042@med.cornell.edu
authors.forename: John W
authors.initials: JW
authors.lastname: Cave
mesh_terms: D000818:Animals; D001665:Binding Sites; D044127:Epigenesis, Genetic; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D051819:Immunoglobulin J Recombination Signal Sequence-Binding Protein / Q000235:genetics / Q000502:physiology; D008954:Models, Biological; D040901:Proteomics; D051880:Receptors, Notch / Q000235:genetics* / Q000502:physiology*; D012097:Repressor Proteins / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D014158:Transcription, Genetic
chemical_list: D051819:Immunoglobulin J Recombination Signal Sequence-Binding Protein; D051880:Receptors, Notch; D012097:Repressor Proteins