title: Oncocytic lesions (oncocytoma) of the ocular adnexa:  report of 15 cases and review of literature.
abstract: OBJECTIVE
  To describe the clinical, imaging, and pathology features of oncocytic lesions in the ocular adnexa.
  
  
  METHODS
  Retrospective, noncomparative, interventional case series.
  
  
  RESULTS
  Fifteen oncocytic neoplasms (n = 15 patients) were classified as oncocytoma in 14 (93%) and oncocytic hyperplasia in 1 (7%). The mean patient age was 66 years (median = 66, range = 44-82), and 9 (60%) were male. The tumor involved the caruncle (n = 13, 86%), bulbar conjunctiva (n = 1, 7%), and plica semilunaris (n = 1, 7%). All cases were unifocal and most often presented as a painless mass (n = 12, 80%), evolving over a median 6 months (mean = 12, range = 1-48 months). The mean tumor base was 4.1 mm (median = 4.0, range = 1-10), and the tumor was well-circumscribed (n = 14), dark blue (n = 7), and cystic (n = 10). Ultrasound biomicroscopy and anterior segment optical coherence tomography disclosed mixed solid and cystic components. Complete surgical excision was curative without recurrence after a mean follow up of 39 months. Histopathology disclosed columnar cells with copious quantities of intensely eosinophilic cytoplasm in the lining epithelium (oncocytic hyperplasia) and in some cases with cystadenomatous proliferation (oncocytoma).
  
  
  CONCLUSIONS
  Oncocytic lesions of the ocular adnexae are typically well-circumscribed, cystic lesions that most often involve the caruncle. Surgical excision can be curative. Epithelial cells with copious quantities of intensely eosinophilic cytoplasm characterize oncocytic transformation histopathologically.
authors.affiliation: The Ocular Oncology Service and Department of Pathology of the Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
authors.forename: Emil Anthony T
authors.initials: EA
authors.lastname: Say
authors.forename: Carol L
authors.initials: CL
authors.lastname: Shields
authors.forename: Carlos
authors.initials: C
authors.lastname: Bianciotto
authors.forename: Ralph C
authors.initials: RC
authors.lastname: Eagle
authors.forename: Jerry A
authors.initials: JA
authors.lastname: Shields
mesh_terms: D018249:Adenoma, Oxyphilic / Q000473:pathology* / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D003230:Conjunctival Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009918:Orbital Neoplasms / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies