title: Viscosupplementation in haemophilic arthropathy: a long-term follow-up study.
abstract: Haemophilic arthropathy is the most common clinical manifestation of haemophilia, secondary to recurrent haemarthroses and chronic synovitis. Modern bleeding-preventing drugs have limited significantly the incidence of severe arthropathy, and primary approach is usually conservative. Use of intra-articular injections of hyaluronan acid is considered one of the most efficient treatments for early stages of articular degenerative diseases. Assessment of long-term effectiveness of intra-articular administration of hyaluronic acid (HA) in knees, ankles and elbows of patients affected by haemophilic arthropathy was done for 46 patients (10 elbows, 24 knees and 25 ankles) affected by haemophilic arthropathy. They received injections of HA and were evaluated with Visual Analogue Scale, Short Form-36, World Federation of Haemophilia score and Petterson score with a 6-year mean follow-up. Most of the patients showed improvement in pain relief and functional recovery without any complications: only a limited number of patients (8.6%) found poor results, undergoing surgery or other further treatments in the follow-up period for persistent pain or limitation. Viscosupplementation is an effective therapeutic strategy in early stages of haemophilic arthropathy, with no complications and long-term good clinical results.
authors.affiliation: First Orthopaedic Clinic, Orthopaedic Traumatologic Center, University of Florence, Florence, Italy. christian.carulli@unifi.it
authors.forename: C
authors.initials: C
authors.lastname: Carulli
authors.forename: R
authors.initials: R
authors.lastname: Civinini
authors.forename: C
authors.initials: C
authors.lastname: Martini
authors.forename: S
authors.initials: S
authors.lastname: Linari
authors.forename: M
authors.initials: M
authors.lastname: Morfini
authors.forename: M
authors.initials: M
authors.lastname: Tani
authors.forename: M
authors.initials: M
authors.lastname: Innocenti
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006467:Hemophilia A / Q000150:complications* / Q000188:drug therapy; D002836:Hemophilia B / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D007270:Injections, Intra-Articular; D007592:Joint Diseases / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D010146:Pain / Q000188:drug therapy; D010147:Pain Measurement; D011788:Quality of Life; D020127:Recovery of Function; D012720:Severity of Illness Index; D055675:Viscosupplements / Q000008:administration & dosage / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D055675:Viscosupplements; D006820:Hyaluronic Acid