title: A case of organizing pneumonia induced by tocilizumab.
abstract: A 66-year-old woman rheumatoid arthritis was treated with methotrexate and tocilizumab. Chest radiography revealed bilateral consolidation of an upper lesion in the lung. Laboratory data indicated a hepatic disorder and increased eosinophils. Transbronchial lung biopsy specimens showed organizing pneumonia. Infection was unfavorable based on culture and PCR. Drug lymphocyte stimulation test showed positive results both for methotrexate and tocilizumab. We were concerned that her pneumonitis was drug-induced. And the symptoms appeared after the infusion of tocilizumab. Here, we report a case of tocilizumab-induced organizing pneumonia.
authors.affiliation: The First Department of Internal Medicine, Shinshu University School of Medicine, Japan.
authors.forename: Kayoko
authors.initials: K
authors.lastname: Ikegawa
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hanaoka
authors.forename: Atsuhito
authors.initials: A
authors.lastname: Ushiki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Keishi
authors.initials: K
authors.lastname: Kubo
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000628:therapy; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D011014:Pneumonia / Q000175:diagnosis / Q000209:etiology*; D019947:Receptors, Interleukin-6 / Q000037:antagonists & inhibitors / Q000276:immunology
chemical_list: D061067:Antibodies, Monoclonal, Humanized; C508603:IL6R protein, human; D019947:Receptors, Interleukin-6; C502936:tocilizumab; D008727:Methotrexate