title: Quality of life following percutaneous mitral valve repair with the MitraClip System.
abstract: BACKGROUND
  Percutaneous valve repair with MitraClip System is an emerging alternative for high surgical risk patients with severe mitral regurgitation (MR). QoL is a critical measure of effectiveness of this procedure. We sought to evaluate quality of life (QoL) and NYHA class following this novel procedure.
  
  
  METHODS
  The study included 39 consecutive patients who underwent mitral valve repair with the MitraClip System, both for functional (64%) and degenerative (36%) MR. All patients received the SF-12v2 questionnaire pre-procedure and at 6 months follow-up to assess the physical and mental health.
  
  
  RESULTS
  Acute procedural success was obtained in 100%. Three patients experienced minor procedural complications. At follow-up 86% of patients had MR ≤ 1+ and 14% experienced a moderate MR. Mean pre-procedural SF-12v2 scores of our patients showed a severe impairment of perceived QoL, both for physical and mental scores; after six months a striking improvement in physical (PCS 35.44 vs 44.67, p<0.0001) and mental (MCS 38.07 vs 46.94, p<0.0001) aspect of QoL was observed. Furthermore, physical and mental status upgrading was higher in patients with functional MR. NYHA functional class improved in all patients.
  
  
  CONCLUSIONS
  Our results show an early marked improvement in functional status and physical and mental health in patients underwent percutaneous mitral valve repair with the MitraClip System.
authors.affiliation: Division of Cardiology, Ferrarotto Hospital, University of Catania, Italy. gpussia@hotmail.com
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Ussia
authors.forename: Valeria
authors.initials: V
authors.lastname: Cammalleri
authors.forename: Kunal
authors.initials: K
authors.lastname: Sarkar
authors.forename: Salvatore
authors.initials: S
authors.lastname: Scandura
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Immè
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Pistritto
authors.forename: Anna
authors.initials: A
authors.lastname: Caggegi
authors.forename: Marta
authors.initials: M
authors.lastname: Chiarandà
authors.forename: Sarah
authors.initials: S
authors.lastname: Mangiafico
authors.forename: Marco
authors.initials: M
authors.lastname: Barbanti
authors.forename: Marilena
authors.initials: M
authors.lastname: Scarabelli
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Mulè
authors.forename: Patrizia
authors.initials: P
authors.lastname: Aruta
authors.forename: Corrado
authors.initials: C
authors.lastname: Tamburino
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004185:Disability Evaluation; D005260:Female; D005500:Follow-Up Studies; D006306:Health Surveys; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008297:Male; D008603:Mental Health; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000503:physiopathology / Q000523:psychology* / Q000601:surgery*; D009043:Motor Activity; D011788:Quality of Life; D011795:Surveys and Questionnaires