title: Multicentric encapsulated papillary oncocytic neoplasm of the thyroid: A case diagnosed by a combined cytological, histological, immunohistochemical, and molecular approach.
abstract: Fine-needle aspiration (FNA) diagnosis of oncocytic lesions is challenging. In fact, oncocytic changes occur in inflammatory, hyperplastic, and neoplastic settings, including both benign and malignant tumors. The rare oncocytic variant of papillary thyroid carcinoma (PTC), shows papillae composed by cells with large oncocytic granular cytoplasm featuring clear PTC nuclear features. A morphological similar, but biologically distinct lesion, is the encapsulated papillary oncocytic neoplasia. Here, we first report on FNA, its cytological features together with histological, immunohistochemical, and molecular correlates.
authors.affiliation: University Federico II, Scienze Biomorfologiche e Funzionali, Naples, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Bellevicine
authors.forename: Umberto
authors.initials: U
authors.lastname: Malapelle
authors.forename: Giovanni
authors.initials: G
authors.lastname: Docimo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ciancia
authors.forename: Gennaro
authors.initials: G
authors.lastname: Mossetti
authors.forename: Guido
authors.initials: G
authors.lastname: Pettinato
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Troncone
mesh_terms: D000328:Adult; D044963:Biopsy, Fine-Needle; D002291:Carcinoma, Papillary / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D005260:Female; D015894:Genome, Human; D006801:Humans; D007150:Immunohistochemistry; D024862:Oxyphil Cells / Q000473:pathology; D013961:Thyroid Gland / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D013965:Thyroidectomy