title: Expression of p75(NTR), a marker for basal forebrain cholinergic neurons, in young and aged dogs with or without cognitive dysfunction syndrome.
abstract: The canine cognitive dysfunction syndrome (CDS) has been identified as a natural model for Alzheimer's disease (AD). We have used unbiased stereology to estimate the total number of basal forebrain cholinergic neurons expressing the nerve growth factor p75(NTR) receptor in young, aged cognitively-unimpaired (CU) and aged cognitively-impaired (CI) dogs. Aged-CI dogs showed a ∼20% decrement (p = 0.009) in p75(NTR) neurons compared to both the young and the aged-CU animals. These results suggest that the basal forebrain cholinergic system is affected in dogs with CDS and provide additional support for the use this canine syndrome as a model for AD research.
authors.affiliation: Departamento de Ciencias Clínicas Veterinarias, Facultad de Veterinaria de Lugo, Universidad de Santiago de Compostela, Lugo, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Insua
authors.forename: Angélica
authors.initials: A
authors.lastname: Corredoira
authors.forename: Angela
authors.initials: A
authors.lastname: González-Martínez
authors.forename: María-Luisa
authors.initials: ML
authors.lastname: Suárez
authors.forename: Germán
authors.initials: G
authors.lastname: Santamarina
authors.forename: Manuel
authors.initials: M
authors.lastname: Sarasa
authors.forename: Pedro
authors.initials: P
authors.lastname: Pesini
mesh_terms: D000375:Aging; D000818:Animals; D059329:Cholinergic Neurons / Q000378:metabolism*; D003072:Cognition Disorders / Q000473:pathology*; D004195:Disease Models, Animal; D004285:Dogs; D016548:Prosencephalon / Q000473:pathology*; D020800:Receptor, Nerve Growth Factor / Q000378:metabolism*
chemical_list: D020800:Receptor, Nerve Growth Factor