title: Pleth variability index to predict fluid responsiveness in colorectal surgery.
abstract: BACKGROUND
  Goal-directed fluid therapy during major abdominal surgery may reduce postoperative morbidity. The Pleth Variability Index (PVI), derived from the pulse oximeter waveform, has been shown to be able to predict fluid responsiveness in a number of surgical circumstances. In the present study, we sought to determine whether PVI could predict fluid responsiveness in low-risk colorectal surgery patients who had fluid therapy guided by esophageal Doppler stroke volume measurements.
  
  
  METHODS
  Twenty-five low-risk patients undergoing colorectal resection under general anesthesia were studied. Baseline values for esophageal Doppler stroke volume and PVI taken from finger and ear probes were compared with final values after (a) a 500-mL fluid bolus immediately after induction (steady state) and tracheal intubation before the start of the surgery, and (b) 250-mL boluses given in response to a decrease in stroke volume of 10% during surgery as measured by esophageal Doppler (dynamic). Patients were classified into responders and nonresponders based on a stroke volume increase of >10%.
  
  
  RESULTS
  Baseline PVI at the finger was significantly higher in responders in both steady-state and intraoperative conditions. In steady state, PVI at both finger and earlobe had significant predictive ability of an increase in stroke volume: area under the curve for finger 0.96 (95% confidence interval [CI], 0.88-1.00; P=0.011) and for earlobe 0.98 (95% CI, 0.93-1.00; P=0.008). In dynamic intraoperative conditions, PVI at the finger predicted increases in stroke volume, area under the curve 0.71 (95% CI, 0.57-0.85; P=0.006), but PVI at the earlobe had no predictive value.
  
  
  CONCLUSIONS
  PVI measured at the finger may be able to predict fluid responsiveness during surgery in ventilated patients.
authors.affiliation: Department of Anesthesia, York Hospital, Wigginton Rd., York, YO31 8HE, UK. julian.hood@doctors.org.uk
authors.forename: Julian A
authors.initials: JA
authors.lastname: Hood
authors.forename: R Jonathan T
authors.initials: RJ
authors.lastname: Wilson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D000768:Anesthesia, General; D019540:Area Under Curve; D003107:Colorectal Surgery / Q000379:methods*; D004431:Ear, External / Q000098:blood supply; D017558:Elective Surgical Procedures; D004947:Esophagus / Q000000981:diagnostic imaging; D005260:Female; D005385:Fingers / Q000098:blood supply; D005440:Fluid Therapy / Q000379:methods* / Q000706:statistics & numerical data; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D010092:Oximetry / Q000706:statistics & numerical data*; D011237:Predictive Value of Tests; D012039:Regional Blood Flow / Q000502:physiology; D013318:Stroke Volume / Q000502:physiology; D014463:Ultrasonography; D055815:Young Adult