title: Immunotoxicity of 1-methyl-3-octylimidazolium bromide on brocarded carp (Cyprinus carpio L.).
abstract: In the present study, the immunotoxicity of 1-methyl-3-octylimidazolium bromide ([C(8)mim]Br) on brocarded carp was evaluated by an acute exposure of 100-300mgL(-1) of [C(8)mim]Br for 7 days. The results showed 300mgL(-1) of [C(8)mim]Br exposure caused activity inhibition of specific and non-specific immune systems, mainly including IgM level, lysozyme activity, and complement C3 content, while 100mgL(-1) of [C(8)mim]Br activated fish immune system during the early periods of exposure (2-5 days). This result indicates that [C(8)mim]Br has immunotoxicity on brocarded carp. Additionally, histological observation revealed that 300mgL(-1) of [C(8)mim]Br-exposure led to remarkable damages to the hepatopancreas, kidney, and spleen of brocarded carp after 7 days of [C(8)mim]Br treatment, although not only change in kidney and spleen somatic indexes was found, but also no swelling or hemorrhage of carp viscera occurred.
authors.affiliation: College of Life Science, Henan Normal University, Xinxiang, Henan, China. lixiaoyu65@263.net
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Li
authors.forename: Xiao-Qing
authors.initials: XQ
authors.lastname: Miao
authors.forename: Lan-Fang
authors.initials: LF
authors.lastname: Zhang
authors.forename: Jian-Ji
authors.initials: JJ
authors.lastname: Wang
mesh_terms: D000818:Animals; D002347:Carps / Q000276:immunology* / Q000502:physiology; D003176:Complement C3 / Q000378:metabolism; D007093:Imidazoles / Q000633:toxicity*; D007107:Immune System / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D013154:Spleen / Q000187:drug effects / Q000276:immunology / Q000378:metabolism
chemical_list: C534649:1-methyl-3-octylimidazolium bromide; D003176:Complement C3; D007093:Imidazoles