title: Linking pharmacology to clinical reports: cyclobenzaprine and its possible association with serotonin syndrome.
abstract: The link between cyclobenzaprine (Flexeril) administration and serotonin syndrome (SS) is subject to debate. Establishing such a connection is difficult because of the limited number of case reports available and the almost complete ignorance of its preclinical pharmacology. In this context, evidence is provided here that cyclobenzaprine blocks the serotonin and norepinephrine transporters and binds to another set of five serotonin receptors. SS should be considered when indicative signs occur in the context of cyclobenzaprine use.
authors.affiliation: Chemogenomics Laboratory, IMIM-Hospital del Mar and University Pompeu Fabra, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Mestres
authors.forename: S A
authors.initials: SA
authors.lastname: Seifert
authors.forename: T I
authors.initials: TI
authors.lastname: Oprea
mesh_terms: D000639:Amitriptyline / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects* / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D050484:Norepinephrine Plasma Membrane Transport Proteins / Q000037:antagonists & inhibitors; D011485:Protein Binding; D011985:Receptors, Serotonin / Q000378:metabolism; D050486:Serotonin Plasma Membrane Transport Proteins / Q000187:drug effects / Q000378:metabolism; D020230:Serotonin Syndrome / Q000139:chemically induced*
chemical_list: D000929:Antidepressive Agents, Tricyclic; D050484:Norepinephrine Plasma Membrane Transport Proteins; D011985:Receptors, Serotonin; D050486:Serotonin Plasma Membrane Transport Proteins; D000639:Amitriptyline; C004704:cyclobenzaprine