title: Reproducibility of 3D 1H MR spectroscopic imaging of the prostate at 1.5T.
abstract: OBJECTIVE
  To determine the reproducibility of 3D proton magnetic resonance spectroscopic imaging ((1)H-MRSI) of the human prostate in a multicenter setting at 1.5T.
  
  
  METHODS
  Fourteen subjects were measured twice with 3D point-resolved spectroscopy (PRESS) (1)H-MRSI using an endorectal coil. MRSI voxels were selected in the peripheral zone and combined central gland at the same location in the prostate in both measurements. Voxels with approved spectral quality were included to calculate Bland-Altman parameters for reproducibility from the choline plus creatine to citrate ratio (CC/C). The repeated spectroscopic data were also evaluated with a standardized clinical scoring system.
  
  
  RESULTS
  A total of 74 voxels were included for reproducibility analysis. The complete range of biologically interesting CC/C ratios was covered. The overall within-voxel standard deviation (SD) of the CC/C ratio of the repeated measurements was 0.13. This value is equal to the between-subject SD of noncancer prostate tissue. In >90% of the voxels the standardized clinical score did not differ relevantly between the measurements.
  
  
  CONCLUSIONS
  Repeated measurements of in vivo 3D (1)H-MRSI of the complete prostate at 1.5T produce equal and quantitative results. The reproducibility of the technique is high enough to provide it as a reliable tool in assessing tumor presence in the prostate.
authors.affiliation: Department of Radiology (767), Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands. m.lagemaat@rad.umcn.nl
authors.forename: Miriam W
authors.initials: MW
authors.lastname: Lagemaat
authors.forename: Christian M
authors.initials: CM
authors.lastname: Zechmann
authors.forename: Jurgen J
authors.initials: JJ
authors.lastname: Fütterer
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Weiland
authors.forename: Jianping
authors.initials: J
authors.lastname: Lu
authors.forename: Geert M
authors.initials: GM
authors.lastname: Villeirs
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Holshouser
authors.forename: Paul
authors.initials: P
authors.lastname: van Hecke
authors.forename: Marc
authors.initials: M
authors.lastname: Lemort
authors.forename: Heinz-Peter
authors.initials: HP
authors.lastname: Schlemmer
authors.forename: Jelle O
authors.initials: JO
authors.lastname: Barentsz
authors.forename: Stefan O
authors.initials: SO
authors.lastname: Roell
authors.forename: Arend
authors.initials: A
authors.lastname: Heerschap
authors.forename: Tom W J
authors.initials: TW
authors.lastname: Scheenen
mesh_terms: D000328:Adult; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008495:Medical Oncology / Q000379:methods; D015233:Models, Statistical; D015588:Observer Variation; D011467:Prostate / Q000473:pathology; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D015203:Reproducibility of Results; D013053:Spectrophotometry / Q000379:methods