title: Combinational Effects of Prebiotics and Soybean against Azoxymethane-Induced Colon Cancer  In Vivo.
abstract: Prebiotic fructans are nondigestible carbohydrates with numerous health benefits. Soybean is a rich source of phytonutrients such as isoflavones. The objective of this study was to evaluate the chemopreventive effects of prebiotics (Synergy1) and soybean meal (SM) at 5% and 10% levels alone and in combination on azoxymethane- (AOM-) induced colon carcinogenesis. After one wk of acclimatization, Fisher 344 male rats (N = 90) were randomly assigned to 9 groups (n = 10). Control rats (C) were fed AIN-93G/M. Two s/c injections of AOM were administered to rats at 7 and 8 wk of age at 16 mg/kg body weight. Rats were killed by CO(2) asphyxiation at 45 wk. Tumor incidence (%) in treatment groups ranged from 40 to 75 compared to 100 in C. Results indicate that feeding prebiotics and soybean in combination significantly reduced incidence of AOM-induced colon tumors with implications for food industry in the food-product development.
authors.affiliation: Nutrition Biochemistry and Carcinogenesis Laboratory, Department of Food and Animal Sciences, Alabama A&M University, Normal, AL 35762, USA.
authors.forename: V P
authors.initials: VP
authors.lastname: Gourineni
authors.forename: M
authors.initials: M
authors.lastname: Verghese
authors.forename: J
authors.initials: J
authors.lastname: Boateng
authors.forename: L
authors.initials: L
authors.lastname: Shackelford
authors.forename: N K
authors.initials: NK
authors.lastname: Bhat
authors.forename: L T
authors.initials: LT
authors.lastname: Walker