title: Drug solubilization effect of lauroyl-L-glutamate.
abstract: This article proposes a new technique for the solubilization of poorly soluble drugs using lauroyl-L-glutamate, which is one of the amino acid detergents, with additional small additives. Lauroyl-L-glutamate was highly effective in solubilizing long-chain alkyl gallates, e.g. dodecyl gallate. Furthermore, lauroyl-L-glutamate and small additives, particularly arginine, acted to increase the solubility of alkyl gallates. The synergistic effect was not observed by sodium dodecyl sulphate with arginine. The solubilizing system can be applied to other drugs because of the low toxicity of both lauroyl-L-glutamate and arginine.
authors.affiliation: Institute of Applied Physics, University of Tsukuba, Tsukuba, Ibaraki 305-8573, Japan.
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Ariki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hirano
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Arakawa
authors.forename: Kentaro
authors.initials: K
authors.lastname: Shiraki
mesh_terms: D000465:Algorithms; D001120:Arginine / Q000737:chemistry / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004735:Energy Transfer; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D005971:Glutamates / Q000737:chemistry* / Q000494:pharmacology; D008956:Models, Chemical; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry / Q000494:pharmacology; D012995:Solubility / Q000187:drug effects; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D005971:Glutamates; D004364:Pharmaceutical Preparations; D012967:Sodium Dodecyl Sulfate; C008259:lauryl gallate; D005707:Gallic Acid; D001120:Arginine; C085318:N-dodecanoylglutamic acid