title: Endoscopic therapy for severe ulcer bleeding.
abstract: Upper gastrointestinal (UGI) bleeding secondary to ulcer disease occurs commonly and results in significant patient morbidity and medical expense. After initial resuscitation, carefully performed endoscopy provides an accurate diagnosis of the source of the UGI hemorrhage and can reliably identify those high-risk subgroups that may benefit most from endoscopic hemostasis. Effective endoscopic hemostasis of ulcer bleeding can significantly improve outcomes by reducing rebleeding, transfusion requirement, and need for surgery, as well as reduce the cost of medical care. This article discusses the important aspects of the diagnosis and treatment of bleeding from ulcers, with a focus on endoscopic therapy.
authors.affiliation: CURE Digestive Diseases Research Center, David Geffen School of Medicine at UCLA, Ronald Reagan Medical Center, VA Greater Los Angeles Healthcare System, CA 90073-1003, USA. tkovacs@mednet.ucla.edu
authors.forename: Thomas O G
authors.initials: TO
authors.lastname: Kovacs
authors.forename: Dennis M
authors.initials: DM
authors.lastname: Jensen
mesh_terms: D003131:Combined Modality Therapy; D004564:Electrocoagulation / Q000379:methods; D016099:Endoscopy, Gastrointestinal; D004837:Epinephrine / Q000008:administration & dosage; D004917:Erythromycin / Q000008:administration & dosage; D016558:Hemostasis, Endoscopic; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D010438:Peptic Ulcer Hemorrhage / Q000175:diagnosis / Q000628:therapy*; D012151:Resuscitation / Q000379:methods; D018570:Risk Assessment; D013525:Surgical Instruments; D014014:Tissue Adhesives / Q000008:administration & dosage; D018608:Ultrasonography, Doppler
chemical_list: D014014:Tissue Adhesives; D004917:Erythromycin; D004837:Epinephrine