title: [Dapsone for chronic skin lesions in 3 children suffering from Henoch-Schönlein vasculitis].
abstract: We describe 3 cases of chronic purpuric skin lesions in children suffering from systemic vasculitis: 3 children with Henoch-Schönlein purpura. Dapsone was introduced when skin lesions were recurrent, extensive, and persistent, due to its known ability to act as an anti-IgA and as an anticytotoxic agent against polynuclear neutrophils. Fast and complete but purely suspensive healing of skin lesions was noted. One child developed methemoglobinemia, a known side-effect of dapsone, highlighting the need for adequate prescription and follow-up.
authors.affiliation: Service de pédiatrie-1, hôpital de Hautepierre, CHRU de Strasbourg, 67098 Strasbourg, France.
authors.forename: N
authors.initials: N
authors.lastname: Mazille
authors.forename: D
authors.initials: D
authors.lastname: Lipsker
authors.forename: M
authors.initials: M
authors.lastname: Fischbach
mesh_terms: D000293:Adolescent; D003622:Dapsone / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications*; D008297:Male; D012871:Skin Diseases / Q000188:drug therapy* / Q000209:etiology*
chemical_list: D003622:Dapsone