title: Brain mapping biomarkers of socio-emotional processing in schizophrenia.
abstract: The Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) initiative has formed with the expressed intent of identifying constructs and paradigms that would identify biomarkers of psychosis. The manipulation of these biomarkers would serve as targets for treatment interventions. The second phase of CNTRICS consisted of critical discussions evaluating brain mapping (functional neuroimaging and brain electrical activity) paradigms as biomarkers to measure specific constructs. Among the constructs identified in, CNTRICS I was socio-emotional processing, specifically focused on affect recognition. Here, we provide a critical appraisal of the ability of candidate socio-emotional tasks to identify putative biomarkers and recommendations for future directions in this rapidly moving research domain.
authors.affiliation: Department of Psychiatry, University of Michigan, Rachel Upjohn Building, 4250 Plymouth Road, Ann Arbor, MI 48109-2700, USA. sftaylor@umich.edu
authors.forename: Stephan F
authors.initials: SF
authors.lastname: Taylor
authors.forename: Angus W
authors.initials: AW
authors.lastname: MacDonald
mesh_terms: D015415:Biomarkers; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods*; D003072:Cognition Disorders / Q000150:complications / Q000503:physiopathology*; D004644:Emotions / Q000502:physiology*; D005071:Evoked Potentials; D005145:Face; D006801:Humans; D008279:Magnetic Resonance Imaging; D010364:Pattern Recognition, Visual / Q000502:physiology; D011594:Psychometrics / Q000295:instrumentation; D012559:Schizophrenia / Q000150:complications / Q000503:physiopathology*; D012920:Social Behavior Disorders / Q000150:complications / Q000503:physiopathology*
chemical_list: D015415:Biomarkers