title: A comparative study of antioxidant vitamins and simvastatin in hypercholesterolimic rabbits.
abstract: The anti-lipidemic effects of orally administered antioxidant vitamins (vitamin A, vitamin C and vitamin E) individually and in combination were studied in cholesterol-fed rabbits and compared to the group of hypercholesterolemic animals that were treated with simvastatin. All treatment groups exhibited a decrease in serum total cholesterol, low density lipoprotein-cholesterol (LDL-C) and triglycerides concentrations, whilst vitamin C, vitamin E, the combination and simvastatin showed a more profound decrease in the lipid profile than vitamin A at different time intervals. The order of increase in high density lipoprotein-cholesterol (HDL-C) levels remained in favour of simvastatin, as none of the antioxidant vitamins treated group could exhibit a profound increase in the HDL-C.
authors.affiliation: University College of Pharmacy, University of the Punjab, Lahore, Pakistan. snihusain@yahoo.com
authors.forename: Nawazish-I-Husain
authors.initials: NI
authors.lastname: Syed
authors.forename: Shamas
authors.initials: S
authors.lastname: Arshad
authors.forename: Amir Ali Rizvi
authors.initials: AA
authors.lastname: Syed
authors.forename: Maqsood
authors.initials: M
authors.lastname: Ahmad
authors.forename: Farrakh Zia
authors.initials: FZ
authors.lastname: Khan
authors.forename: Bashir
authors.initials: B
authors.lastname: Ahmad
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000494:pharmacology / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000494:pharmacology; D008076:Cholesterol, HDL / Q000097:blood / Q000187:drug effects; D008078:Cholesterol, LDL / Q000097:blood / Q000187:drug effects; D006937:Hypercholesterolemia / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D011817:Rabbits; D019821:Simvastatin / Q000494:pharmacology / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood; D014801:Vitamin A / Q000494:pharmacology / Q000627:therapeutic use; D014810:Vitamin E / Q000494:pharmacology / Q000627:therapeutic use; D014815:Vitamins / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D014815:Vitamins; D014801:Vitamin A; D014810:Vitamin E; D002784:Cholesterol; D019821:Simvastatin; D001205:Ascorbic Acid