title: On-demand electrochemical activation of the click reaction on self-assembled monolayers on gold presenting masked acetylene groups.
abstract: We report on a new surface modification method for grafting a "dynamic" property for on-demand activation of the click reaction. Our approach utilizes the acetylene group masked with dicobalt hexacarbonyl, Co(2)(CO)(6), which is not reactive toward the click reaction. Electrochemical treatment reveals the acetylene group on the selected region, which is then used as a chemical handle for surface functionalization via the click reaction with an azide-containing molecule. Electrochemical and chemical conversions on the surface were verified by cyclic voltammetry, X-ray photoelectron spectroscopy, and fluorescence spectroscopy. We have demonstrated immobilization of an azide-modified RGD peptide and promotion of cell adhesion/migration to the region of electrochemical induction.
authors.affiliation: Department of Bioscience and Biotechnology, School of Physics, Konkuk University, Seoul 143-701, Korea.
authors.forename: Inseong
authors.initials: I
authors.lastname: Choi
authors.forename: Young-Kwan
authors.initials: YK
authors.lastname: Kim
authors.forename: Dal-Hee
authors.initials: DH
authors.lastname: Min
authors.forename: SangWook
authors.initials: S
authors.lastname: Lee
authors.forename: Woon-Seok
authors.initials: WS
authors.lastname: Yeo
mesh_terms: D000114:Acetylene / Q000737:chemistry*; D001386:Azides / Q000737:chemistry; D002448:Cell Adhesion; D057930:Click Chemistry; D004563:Electrochemistry; D006046:Gold / Q000737:chemistry*; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D001386:Azides; D009842:Oligopeptides; D006046:Gold; C047981:arginyl-glycyl-aspartic acid; D000114:Acetylene