title: Design and implementation of the TRACIA: intracoronary autologous transplant of bone marrow-derived stem cells for acute ST elevation myocardial infarction.
abstract: OBJECTIVE
  To describe the design of a protocol of intracoronary autologous transplant of bone marrow-derived stem cells for acute ST-elevation myocardial infarction (STEMI) and to report the safety of the procedure in the first patients included.
  
  
  METHODS
  The TRACIA study was implemented following predetermined inclusion and exclusion criteria. The protocol includes procedures such as randomization, bone marrow retrieval, stem cells processing, intracoronary infusion of stem cells in the infarct-related artery, preand- post MRI, pre-and-post SPECT with radioisotope ventriculography, and clinical follow-up at 6 months.
  
  
  RESULTS
  Eight patients with a diagnosis of acute STEMI and duration of symptoms of ?24 hours that were perfused successfully through primary percutaneous coronary intervention (PPCI) with a LVEF of ?45% were assigned randomly to two groups (n = 4 each). One group treated with stem cells and the other corresponded to the control group. Neither death, re-infarction, no need for revascularization or thrombosis of the stent were observed at follow-up.
  
  
  CONCLUSIONS
  The initial experience at the Instituto Nacional de Cardiología Ignacio Chávez in the treatment of acute STEMI by means of autologous transplantation of bone marrow-derived stem cells is encouraging. Implementation was possible in the first eight patients with no complications.
authors.affiliation: Instituto Nacional de Cardiología Ignacio Chávez. The contributions by Marco A. Peña-Duque and Marco A. Martínez-Ríos are equal and the order of authorship is arbitrary.
authors.forename: Marco A
authors.initials: MA
authors.lastname: Peña-Duque
authors.forename: Marco A
authors.initials: MA
authors.lastname: Martínez-Ríos
authors.forename: Eva
authors.initials: E
authors.lastname: Calderón G
authors.forename: Ana M
authors.initials: AM
authors.lastname: Mejía
authors.forename: Enrique
authors.initials: E
authors.lastname: Gómez
authors.forename: Carlos
authors.initials: C
authors.lastname: Martínez-Sánchez
authors.forename: Javier
authors.initials: J
authors.lastname: Figueroa
authors.forename: Jorge
authors.initials: J
authors.lastname: Gaspar
authors.forename: Héctor
authors.initials: H
authors.lastname: González
authors.forename: David
authors.initials: D
authors.lastname: Bialoztosky
authors.forename: Aloha
authors.initials: A
authors.lastname: Meave
authors.forename: Jhonathan
authors.initials: J
authors.lastname: Uribe-González
authors.forename: Erick
authors.initials: E
authors.lastname: Alexánderson
authors.forename: Victor
authors.initials: V
authors.lastname: Ochoa
authors.forename: Felipe
authors.initials: F
authors.lastname: Masso
mesh_terms: D001854:Bone Marrow Cells; D003331:Coronary Vessels; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000601:surgery*; D016037:Single-Blind Method; D014182:Transplantation, Autologous / Q000379:methods