title: Anaemia is of prognostic significance in patients with oesophageal adenocarcinoma.
abstract: Anaemia is common in a wide range of malignancies and individual studies have demonstrated it to be an independent prognostic marker for survival in certain cancer types. The study population consisted of 171 patients: 77 anaemic and 94 non-anaemic. Sixty per cent of the study population had adenocarcinoma with 37% having squamous cell carcinoma. Late-stage disease occurred in 80% of individuals. There was no significant difference in survival times between the two groups (p=0.1), and after adjusting for confounding factors including age, sex, stage and physical status (p=0.8). Anaemic individuals with adenocarcinoma suffered a poorer survival probability compared to those with normal haemoglobon level (p=0.02). Anaemia is common at diagnosis in oesophageal cancer and was found to be a significant prognostic indicator of survival in adenocarcinoma, but not squamous cell carcinoma.
authors.affiliation: Gastroenterology Department, The Princess Royal Hospital, Apley Castle, Telford, Shropshire, UK. ian.tanswell@sath.nhs.uk
authors.forename: I
authors.initials: I
authors.lastname: Tanswell
authors.forename: H
authors.initials: H
authors.lastname: Steed
authors.forename: J
authors.initials: J
authors.lastname: Butterworth
authors.forename: G
authors.initials: G
authors.lastname: Townson
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000401:mortality*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000097:blood / Q000209:etiology; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000401:mortality*; D018450:Disease Progression; D004938:Esophageal Neoplasms / Q000097:blood / Q000401:mortality*; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis
chemical_list: D006454:Hemoglobins