title: Toll-like receptor activation by helminths or helminth products to alleviate inflammatory bowel disease.
abstract: Helminth infection may modulate the expression of Toll like receptors (TLR) in dendritic cells (DCs) and modify the responsiveness of DCs to TLR ligands. This may regulate aberrant intestinal inflammation in humans with helminthes and may thus help alleviate inflammation associated with human inflammatory bowel disease (IBD). Epidemiological and experimental data provide further evidence that reducing helminth infections increases the incidence rate of such autoimmune diseases. Fine control of inflammation in the TLR pathway is highly desirable for effective host defense. Thus, the use of antagonists of TLR-signaling and agonists of their negative regulators from helminths or helminth products should be considered for the treatment of IBD.
authors.affiliation: Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, Jilin University, Zoonosis Research Centre of State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences, Changchun 130062, People's Republic of China.
authors.forename: ShuMin
authors.initials: S
authors.lastname: Sun
authors.forename: XueLin
authors.initials: X
authors.lastname: Wang
authors.forename: XiuPing
authors.initials: X
authors.lastname: Wu
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhao
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.forename: XiaoLei
authors.initials: X
authors.lastname: Liu
authors.forename: Yanxia
authors.initials: Y
authors.lastname: Song
authors.forename: ZhiLiang
authors.initials: Z
authors.lastname: Wu
authors.forename: MingYuan
authors.initials: M
authors.lastname: Liu
mesh_terms: D000818:Animals; D015801:Helminth Proteins / Q000276:immunology / Q000627:therapeutic use*; D006373:Helminthiasis / Q000276:immunology / Q000469:parasitology; D006376:Helminths / Q000276:immunology* / Q000502:physiology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy* / Q000276:immunology* / Q000469:parasitology; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000276:immunology*
chemical_list: D015801:Helminth Proteins; D051193:Toll-Like Receptors