title: Synthesis of new Galβ1→4Fuc segments useful for biological investigations.
abstract: Useful segments (1, 2) for chemical probes embedded in a Galβ1→4Fuc unit were designed and prepared for characterizing sugar-binding proteins in Caenorhabditis elegans. Segment 1 with an amino group terminus was used as a recognition unit in affinity chromatography. It was revealed that some proteins (annexins and galectins) in C. elegans have an affinity for Galβ1→4Fuc.
authors.affiliation: School of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan.
authors.forename: Kazusa
authors.initials: K
authors.lastname: Nishiyama
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yamada
authors.forename: Tomoharu
authors.initials: T
authors.lastname: Takeuchi
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Arata
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Kasai
authors.forename: Tetsuta
authors.initials: T
authors.lastname: Oshitari
authors.forename: Hideaki
authors.initials: H
authors.lastname: Natsugari
authors.forename: Hideyo
authors.initials: H
authors.lastname: Takahashi
mesh_terms: D000818:Animals; D001665:Binding Sites; D017173:Caenorhabditis elegans; D029742:Caenorhabditis elegans Proteins; D002846:Chromatography, Affinity; D005643:Fucose / Q000737:chemistry*; D005690:Galactose / Q000737:chemistry*; D037161:Galectins / Q000737:chemistry / Q000378:metabolism; D015335:Molecular Probes / Q000032:analysis / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D009844:Oligosaccharides / Q000737:chemistry* / Q000378:metabolism
chemical_list: D029742:Caenorhabditis elegans Proteins; D037161:Galectins; D015335:Molecular Probes; D009844:Oligosaccharides; D005643:Fucose; D005690:Galactose