title: F4/80 and the related adhesion-GPCRs.
abstract: The F4/80 monoclonal antibody was first reported in this journal 30 years ago (Eur. J. Immunol. 1981. 11: 805-815). F4/80 has become a widely used marker for monocytes and many, but not all, tissue macrophages in the mouse. F4/80 is a member of the EGF-TM7 family of leukocyte plasma membrane heptahelical molecules, which includes CD97 and EMR2. This Viewpoint summarises current knowledge of the expression, structure and functions of the EGF-TM7 family, as part of a larger family of tissue adhesion-GPCRs.
authors.affiliation: Sir William Dunn School of Pathology, University of Oxford, Oxford, UK. siamon.gordon@path.ox.ac.uk
authors.forename: Siamon
authors.initials: S
authors.lastname: Gordon
authors.forename: Jörg
authors.initials: J
authors.lastname: Hamann
authors.forename: Hsi-Hsien
authors.initials: HH
authors.lastname: Lin
authors.forename: Martin
authors.initials: M
authors.lastname: Stacey
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D000943:Antigens, Differentiation / Q000276:immunology* / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D002448:Cell Adhesion / Q000276:immunology; D002454:Cell Differentiation; D006801:Humans; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D009000:Monocytes / Q000276:immunology*; D043562:Receptors, G-Protein-Coupled / Q000276:immunology*
chemical_list: C412456:ADGRE2 protein, human; C095004:ADGRE5 protein, human; D015703:Antigens, CD; D000943:Antigens, Differentiation; D015415:Biomarkers; D043562:Receptors, G-Protein-Coupled; C036763:monocyte-macrophage differentiation antigen