title: Early anti-angiogenic proteins expression in amniotic fluid of twin fetuses.
abstract: Multiple pregnancies are thought to be associated with a high incidence of perinatal complications such as preterm labor, preeclampsia and low birth weight. But the true mechanisms of these obstetric complications are still uncertain. The components of amniotic fluid reflect the pathophysiology features of the fetus. Amniotic fluid soluble fms-like tyrosine kinase 1(sFLT1), soluble endoglin (sENG), and adiponectin reflect the oxidative stress and pro-inflammatory status and are associated with preeclampsia and fetal growth restriction. We prospectively collected amniotic fluids during amniocentesis from singleton and twin pregnancies. Samples were analyzed for levels of sFLT1, sENG, and adiponectin by enzyme-linked immunosorbent assay. The levels of sENG and sFLT1 were significantly increased in twin pregnancies. Adiponectin was not significantly different between the two groups. These findings would suggest that twin fetuses suffer from more oxidative stress and pro-inflammatory status from the early trimesters.
authors.affiliation: Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Chang Gung University, Taiwan.
authors.forename: Chao-Nin
authors.initials: CN
authors.lastname: Wang
authors.forename: Jannie Ying-Syuan
authors.initials: JY
authors.lastname: Chen
authors.forename: An-Shine
authors.initials: AS
authors.lastname: Chao
authors.forename: Po-Jen
authors.initials: PJ
authors.lastname: Cheng
authors.forename: Shuenn-Dyh
authors.initials: SD
authors.lastname: Chang
authors.forename: Tzu-Hao
authors.initials: TH
authors.lastname: Wang
mesh_terms: D052242:Adiponectin / Q000378:metabolism; D000328:Adult; D000653:Amniotic Fluid / Q000378:metabolism*; D042501:Angiogenic Proteins / Q000378:metabolism*; D015703:Antigens, CD / Q000378:metabolism*; D000071063:Endoglin; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005333:Fetus / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D007249:Inflammation / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress; D011247:Pregnancy; D059285:Pregnancy, Twin; D011446:Prospective Studies; D011956:Receptors, Cell Surface / Q000378:metabolism*; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000378:metabolism*
chemical_list: D052242:Adiponectin; D042501:Angiogenic Proteins; D015703:Antigens, CD; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1