title: Microbial-induced immunomodulation by targeting the NF-κB system.
abstract: Virtually all eukaryotes have developed defense mechanisms to efficiently counter potential threats from prokaryotic microorganisms; an example is the conserved nuclear factor-kappaB (NF-κB) signaling system. However, bacterial pathogens and commensals have in turn evolved highly effective counter mechanisms to modulate this immune regulatory circuit. Modifications in ubiquitin, ubiquitin-like (Ubl) proteins such as neural precursor cell expressed, developmentally down-regulated 8 (NEDD8) and other post-translational modifications (PTMs) in the NF-κB system represent attractive targets for microbial manipulation. In this review, we describe recent advances in understanding the different strategies that bacteria have evolved to interfere with PTMs in NF-κB signal transmission.
authors.affiliation: Emory University School of Medicine, Emory University Hospital, Experimental Pathology, 105-F Whitehead Bldg., 615 Michael St., Atlanta, GA 30322, USA.
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Neish
authors.forename: Michael
authors.initials: M
authors.lastname: Naumann
mesh_terms: D000818:Animals; D001419:Bacteria / Q000276:immunology* / Q000378:metabolism / Q000472:pathogenicity; D006801:Humans; D057131:Immune Evasion; D056747:Immunomodulation; D008954:Models, Biological; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000276:immunology*; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction; D037521:Virulence Factors / Q000378:metabolism*
chemical_list: D016328:NF-kappa B; D037521:Virulence Factors