title: [Characteristics of local human skeleton reactions to microgravity and drug treatment of osteoporosis in clinic].
abstract: Analysis of the results of long-term investigations of bones in cosmonauts flown on the orbital station MIR and International space station (n = 80) was performed. Theoretically predicted (evolutionary predefined) change in mass of different skeleton bones was found to correlate (r = 0.904) with position relatively the Earth's gravity vector. Vector dependence of bone loss ensues from local specificity of expression of bone metabolism genes which reflects mechanic prehistory of skeleton structures in the evolution of Homo erectus. Genetic polymorphism is accountable for high individual variability of bone loss attested by the dependence of bone loss rate on polymorphism of certain bone metabolism markers. Parameters of one and the other orbital vehicle did not modulate individual-specific stability of the bone loss ratio in different segments of the skeleton. This fact is considered as a phenotype fingerprint of local metabolism in the form of a locus-unique spatial structure of distribution of noncollagenous proteins responsible for position regulation of endosteal metabolism. Drug treatment of osteoporosis (n = 107) evidences that recovery rate depends on bone location; the most likely reason is different effectiveness of local osteotrophic intervention into areas of bustling resorption.
authors.forename: V S
authors.initials: VS
authors.lastname: Oganov
authors.forename: I A
authors.initials: IA
authors.lastname: Skripnikova
authors.forename: V E
authors.initials: VE
authors.lastname: Novikov
authors.forename: A V
authors.initials: AV
authors.lastname: Bakulin
authors.forename: O E
authors.initials: OE
authors.lastname: Kabitskaia
authors.forename: L M
authors.initials: LM
authors.lastname: Murashko
mesh_terms: D000328:Adult; D000337:Aerospace Medicine; D018480:Astronauts; D015519:Bone Density; D002118:Calcium / Q000627:therapeutic use; D002762:Cholecalciferol / Q000627:therapeutic use; D006112:Gravitation; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000188:drug therapy* / Q000209:etiology*; D013026:Space Flight; D014893:Weightlessness / Q000009:adverse effects*
chemical_list: D002762:Cholecalciferol; D002118:Calcium