title: The nucleoskeleton as a genome-associated dynamic 'network of networks'.
abstract: In the cytosol, actin polymers, intermediate filaments and microtubules can anchor to cell surface adhesions and interlink to form intricate networks. This cytoskeleton is anchored to the nucleus through LINC (links the nucleoskeleton and cytoskeleton) complexes that span the nuclear envelope and in turn anchor to networks of filaments in the nucleus. The metazoan nucleoskeleton includes nuclear pore-linked filaments, A-type and B-type lamin intermediate filaments, nuclear mitotic apparatus (NuMA) networks, spectrins, titin, 'unconventional' polymers of actin and at least ten different myosin and kinesin motors. These elements constitute a poorly understood 'network of networks' that dynamically reorganizes during mitosis and is responsible for genome organization and integrity.
authors.affiliation: Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland         21205, USA.
authors.forename: Dan N
authors.initials: DN
authors.lastname: Simon
authors.forename: Katherine L
authors.initials: KL
authors.lastname: Wilson
mesh_terms: D000818:Animals; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000502:physiology; D003599:Cytoskeleton / Q000235:genetics* / Q000502:physiology*; D053263:Gene Regulatory Networks; D016678:Genome; D006801:Humans; D040542:Mechanotransduction, Cellular; D008938:Mitosis; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000235:genetics / Q000502:physiology; D015530:Nuclear Matrix / Q000235:genetics* / Q000502:physiology*; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction
chemical_list: D003598:Cytoskeletal Proteins; D020409:Molecular Motor Proteins; D009687:Nuclear Proteins