title: Viability of cartilage grafts in various forms.
abstract: The viability of cartilage grafts, in many forms, has been researched since the using of cartilage grafts in surgical procedures. Cryopreservation period and viability of cartilage grafts have remained unclear. This study was performed to investigate the durability, viability, and behavior of fresh or cryopreserved cartilage grafts when used as autografts or allografts in various forms.Six cartilage grafts (1 of each preparation type; 3 blocks and 3 diced) were prepared by wrapping with Surgicel or autogenous fascia, or they were left bare. After the graft preparation stage, the cartilage grafts were inserted into pockets prepared on the dorsum of each rabbit. Groups 1, 2, 3, and 4 (6 rabbits in each group) received autogenous fresh grafts, allogenous fresh grafts, autogenous cryopreserved grafts, and allogenous cryopreserved grafts, respectively. All cartilage grafts were implanted for 2 months.At the end of the second month, specimens were harvested and analyzed. The bare grafts provided the most viable specimens. There was no significant difference between the frozen or fresh and allograft or autograft groups with respect to viability and resorption ratios. The bare block graft, in all groups, survived significantly more than the other graft types.Allografts (homografts), similar autografts, did not create major problems, and they had excellent host tolerance and low antigenicity, especially when the perichondrium was removed. Viability and durability of the bare grafts (diced and block) were better than fascia or Surgicel-wrapped cartilage graft forms.
authors.affiliation: Department of Plastic Surgery, Inonu University School of Medicine, Malatya, Turkey. cemal.firat@inonu.edu.tr
authors.forename: Cemal
authors.initials: C
authors.lastname: Firat
authors.forename: Ali
authors.initials: A
authors.lastname: Gurlek
authors.forename: Nasuhi Engin
authors.initials: NE
authors.lastname: Aydin
authors.forename: Nasuhi Engin
authors.initials: NE
authors.lastname: Aydn
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002483:Cellulose, Oxidized; D015925:Cryopreservation; D004425:Ear Cartilage / Q000637:transplantation*; D005205:Fascia / Q000637:transplantation; D006085:Graft Survival; D011817:Rabbits; D018709:Statistics, Nonparametric; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
chemical_list: D001672:Biocompatible Materials; D002483:Cellulose, Oxidized; C013695:Surgicel