title: The renin-angiotensin-aldosterone system in 2011: role in hypertension and chronic kidney disease.
abstract: Over the past two decades, considerable advances have been made in our understanding of the renin-angiotensin-aldosterone system (RAAS) and its roles in various disease states. In this review, we will discuss the current state of knowledge of the many components of the RAAS, including new data on prorenin and its receptors, and important angiotensin fragments. The roles of these components of the RAAS in the pathogenesis of primary hypertension and the progression of chronic kidney disease (CKD) will also be highlighted. Given the new understanding of the many components and roles of the RAAS, it may be possible to develop improved therapies for hypertension and CKD.
authors.affiliation: Pediatric Nephrology Unit, Department of Pediatrics, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: Simões E Silva
authors.forename: Joseph T
authors.initials: JT
authors.lastname: Flynn
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002319:Cardiovascular System / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000266:history / Q000378:metabolism* / Q000503:physiopathology; D007668:Kidney / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D009398:Nephrology / Q000266:history / Q000639:trends; D051436:Renal Insufficiency, Chronic / Q000188:drug therapy / Q000266:history / Q000378:metabolism* / Q000503:physiopathology; D012084:Renin-Angiotensin System / Q000187:drug effects; D015398:Signal Transduction
chemical_list: D000959:Antihypertensive Agents