title: Extraordinary metabolic stability of peptides containing α-aminoxy acids.
abstract: The metabolic stability of peptides containing a mixed sequence of α-aminoxy acids and α-amino acids is significantly improved compared to peptides composed of only natural α-amino acids. The introduction of an α-aminoxy acid into peptide chain dramatically improves the stability of the amide bonds immediately before and after it. These peptides containing α-aminoxy acids represent excellent structural scaffold for the design of metabolically stable and biologically active peptides.
authors.affiliation: Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, People's Republic of China.
authors.forename: Fei
authors.initials: F
authors.lastname: Chen
authors.forename: Bin
authors.initials: B
authors.lastname: Ma
authors.forename: Zong-Chang
authors.initials: ZC
authors.lastname: Yang
authors.forename: Ge
authors.initials: G
authors.lastname: Lin
authors.forename: Dan
authors.initials: D
authors.lastname: Yang
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D000818:Animals; D008862:Microsomes, Liver / Q000378:metabolism; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism*; D055550:Protein Stability; D017433:Protein Structure, Secondary; D051381:Rats
chemical_list: D000596:Amino Acids; D010455:Peptides