title: Executive function in chronic pain patients and healthy controls: different cortical activation during response inhibition in fibromyalgia.
abstract: The primary symptom of fibromyalgia (FM) is chronic, widespread pain; however, patients report additional symptoms including decreased concentration and memory. Performance-based deficits are seen mainly in tests of working memory and executive function. Neural correlates of executive function were investigated in 18 FM patients and 14 age-matched healthy controls during a simple Go/No-Go task (response inhibition) while they underwent functional magnetic resonance imaging (fMRI). Performance was not different between FM and healthy control, in either reaction time or accuracy. However, fMRI revealed that FM patients had lower activation in the right premotor cortex, supplementary motor area, midcingulate cortex, putamen and, after controlling for anxiety, in the right insular cortex and right inferior frontal gyrus. A hyperactivation in FM patients was seen in the right inferior temporal gyrus/fusiform gyrus. Despite the same reaction times and accuracy, FM patients show less brain activation in cortical structures in the inhibition network (specifically in areas involved in response selection/motor preparation) and the attention network along with increased activation in brain areas not normally part of the inhibition network. We hypothesize that response inhibition and pain perception may rely on partially overlapping networks, and that in chronic pain patients, resources taken up by pain processing may not be available for executive functioning tasks such as response inhibition. Compensatory cortical plasticity may be required to achieve performance on a par with control groups.
  
  
  CONCLUSIONS
  Neural activation (fMRI) during response inhibition was measured in fibromyalgia patients and controls. FM patients show lower activation in the inhibition and attention networks and increased activation in other areas. Inhibition and pain perception may use overlapping networks: resources taken up by pain processing may be unavailable for other processes.
authors.affiliation: Addiction Research Center, Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA. jglass@med.umich.edu
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Glass
authors.forename: David A
authors.initials: DA
authors.lastname: Williams
authors.forename: Maria-Luisa
authors.initials: ML
authors.lastname: Fernandez-Sanchez
authors.forename: Anson
authors.initials: A
authors.lastname: Kairys
authors.forename: Paloma
authors.initials: P
authors.lastname: Barjola
authors.forename: Mary M
authors.initials: MM
authors.lastname: Heitzeg
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Clauw
authors.forename: Tobias
authors.initials: T
authors.lastname: Schmidt-Wilcke
mesh_terms: D000328:Adult; D000339:Affect / Q000502:physiology; D001007:Anxiety / Q000523:psychology; D002540:Cerebral Cortex / Q000503:physiopathology*; D059350:Chronic Pain / Q000150:complications / Q000503:physiopathology* / Q000523:psychology*; D003072:Cognition Disorders / Q000150:complications / Q000523:psychology; D003627:Data Interpretation, Statistical; D003863:Depression / Q000523:psychology; D056344:Executive Function / Q000502:physiology*; D005260:Female; D005356:Fibromyalgia / Q000150:complications / Q000503:physiopathology* / Q000523:psychology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology; D009483:Neuropsychological Tests; D010147:Pain Measurement; D011569:Psychiatric Status Rating Scales; D011597:Psychomotor Performance / Q000502:physiology; D012893:Sleep Wake Disorders / Q000523:psychology; D012959:Socioeconomic Factors