title: The effect of vitamin E on pathological changes in kidney and liver of sulphur mustard-exposed guinea pigs.
abstract: Sulphur mustard (SM) gas is a poisonous chemical agent causing various systemic action in laboratory animals. There is no definite treatment for disorders induced by SM. In this study, the effect of vitamin E alone and in combination with dexamethasone on the pathological changes in the kidney and liver of SM-exposed (SME) guinea pigs was examined. Guinea pigs were divided into five groups (n = 5 in each). These groups were exposed to ethanol (control group), 100 mg/m(3) inhaled SM (SME group), SME treated with vitamin E, 600 mg/kg (SME + E), SME treated with dexamethasone, 5 mg/kg (SME + D), and SME treated with both drugs (SME + E + D), respectively. Pathological evaluation of the kidneys and livers was done 14 days post exposure. There were statistically significant pathological changes in the liver and kidney of SME group compared to control animals (p < 0.05 to p < 0.001). Treatment of SME animals with vitamin E, dexamethasone and their combination caused statistically significant improvement in the pathological changes in the livers and kidneys (p < 0.05 to p < 0.001). These results showed a preventive effect of vitamin E on pathological changes in the liver and more prominently in the kidneys of SME guinea pigs.
authors.affiliation: Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran. boskabadymh@mums.ac.ir
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Boskabady
authors.forename: Abbas
authors.initials: A
authors.lastname: Tabatabayee
authors.forename: Sediqa
authors.initials: S
authors.lastname: Amiri
authors.forename: Nasim
authors.initials: N
authors.lastname: Vahedi
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D007668:Kidney / Q000737:chemistry / Q000187:drug effects* / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000188:drug therapy; D008099:Liver / Q000737:chemistry / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009151:Mustard Gas / Q000633:toxicity*; D014810:Vitamin E / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D014810:Vitamin E; D003907:Dexamethasone; D009151:Mustard Gas