title: Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery.
abstract: Knowledge and investigation of therapeutic targets (responsible for drug efficacy) and the targeted drugs facilitate target and drug discovery and validation. Therapeutic Target Database (TTD, http://bidd.nus.edu.sg/group/ttd/ttd.asp) has been developed to provide comprehensive information about efficacy targets and the corresponding approved, clinical trial and investigative drugs. Since its last update, major improvements and updates have been made to TTD. In addition to the significant increase of data content (from 1894 targets and 5028 drugs to 2025 targets and 17,816 drugs), we added target validation information (drug potency against target, effect against disease models and effect of target knockout, knockdown or genetic variations) for 932 targets, and 841 quantitative structure activity relationship models for active compounds of 228 chemical types against 121 targets. Moreover, we added the data from our previous drug studies including 3681 multi-target agents against 108 target pairs, 116 drug combinations with their synergistic, additive, antagonistic, potentiative or reductive mechanisms, 1427 natural product-derived approved, clinical trial and pre-clinical drugs and cross-links to the clinical trial information page in the ClinicalTrials.gov database for 770 clinical trial drugs. These updates are useful for facilitating target discovery and validation, drug lead discovery and optimization, and the development of multi-target drugs and drug combinations.
authors.affiliation: Bioinformatics and Drug Design Group, Department of Pharmacy, and Center for Computational Science and Engineering, National University of Singapore, Singapore 117543.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhu
authors.forename: Zhe
authors.initials: Z
authors.lastname: Shi
authors.forename: Chu
authors.initials: C
authors.lastname: Qin
authors.forename: Lin
authors.initials: L
authors.lastname: Tao
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Yang
authors.initials: Y
authors.lastname: Song
authors.forename: Xianghui
authors.initials: X
authors.lastname: Liu
authors.forename: Jingxian
authors.initials: J
authors.lastname: Zhang
authors.forename: Bucong
authors.initials: B
authors.lastname: Han
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: Yuzong
authors.initials: Y
authors.lastname: Chen
mesh_terms: D001688:Biological Products / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D016208:Databases, Factual; D055808:Drug Discovery; D004359:Drug Therapy, Combination; D021281:Quantitative Structure-Activity Relationship; D013329:Structure-Activity Relationship
chemical_list: D001688:Biological Products