title: Weaning from mechanical ventilation.
abstract: Mechanical ventilation is often required by very preterm infants with respiratory failure, even if invasive respiratory support is related to lung injury and adverse neurologic outcomes. The exposure to mechanical ventilation should be therefore limited. Optimal extubation however remains challenging, as approximately 30% of intubated preterm infants fails attempted extubation due to poor respiratory drive, atelectasis, residual pulmonary function abnormalities or intercurrent illness. This review outlines the advantages of different weaning strategies that should be considered by neonatologists for current use to reduce unsuccessful extubation.
authors.affiliation: NICU-S. Giovanni Calibita Hospital Fatebenefratelli, Isola Tiberina-Rome, Italy. camillagizzi@tin.it
authors.forename: Camilla
authors.initials: C
authors.lastname: Gizzi
authors.forename: Corrado
authors.initials: C
authors.lastname: Moretti
authors.forename: Rocco
authors.initials: R
authors.lastname: Agostino
mesh_terms: D060666:Airway Extubation / Q000009:adverse effects / Q000379:methods; D006801:Humans; D007231:Infant, Newborn; D007442:Intubation, Intratracheal / Q000009:adverse effects / Q000379:methods; D011379:Prognosis; D012121:Respiration, Artificial / Q000009:adverse effects / Q000379:methods; D012127:Respiratory Distress Syndrome, Newborn / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D016896:Treatment Outcome; D015300:Ventilator Weaning / Q000379:methods* / Q000706:statistics & numerical data