title: [Analysis of efficacy and safety of preventive analgesia with transdermal therapeutic system Duragesic Matrix in spine surgery].
abstract: The survey studies analgesic effect of postoperative therapy in two groups of patients with spinal disorders. In the first group the standard scheme with NSAID on demand was used. In the second group transdermal therapeutic system Duragesic Matrix was applied. The pain level (by pain level scale) as well as psychological status and IL-6 rate (a reliable indicator of surgical trauma and pain severity) were assessed before and after surgery. Transdermal therapeutic system Duragesic Matrix applied before surgery appeared to be more effective for analgesic therapy than standard scheme with NSAID on demand.
authors.forename: A V
authors.initials: AV
authors.lastname: Solenkova
authors.forename: A A
authors.initials: AA
authors.lastname: Imaev
authors.forename: A A
authors.initials: AA
authors.lastname: Bondarenko
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Lubnin
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000698:Analgesia / Q000009:adverse effects / Q000379:methods*; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D005283:Fentanyl / Q000008:administration & dosage*; D006439:Hemodynamics; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D010149:Postoperative Pain / Q000517:prevention & control*; D013116:Spinal Cord / Q000601:surgery*; D013131:Spine / Q000601:surgery*; D055815:Young Adult
chemical_list: D000701:Analgesics, Opioid; D015850:Interleukin-6; D005283:Fentanyl