title: Total desmosines in plasma and urine correlate with lung function.
abstract: The aim of the present study was to evaluate the relationship between the matrix degradation biomarkers, desmosine and isodesmosine (desmosines), and lung function. Plasma and creatinine-corrected urinary total desmosines (P- and U-desmosines, respectively), lung function and diffusing capacity of the lung for carbon monoxide (D(L,CO)) were measured in a cohort of subjects from the Swedish Twin Registry. Concentrations of U- and P-desmosines were measured in 349 and 318 subjects, respectively; approximately one-third of subjects had chronic obstructive pulmonary disease (COPD). Age, female sex, body mass index (BMI) and smoking were significantly associated with U-desmosines in a multiple linear regression analysis. In the overall population, after adjustments for age, sex, height, BMI and smoking, concentrations of U-desmosines were significantly correlated with all lung function measures, and P-desmosines with forced expiratory volume in 1 s and D(L,CO) (p<0.05). With the exception of residual volume versus P-desmosines, relationships between concentrations of desmosines and lung function measures were markedly stronger in subjects with COPD compared with those without COPD. These cross-sectional data showing associations between desmosines and several lung function variables suggest that desmosines, particularly U-desmosines, could be a useful biomarker of COPD status.
authors.affiliation: AstraZeneca R&D, S-221 87 Lund, Sweden. kristina.f.semb@insatnet.nu
authors.forename: C A
authors.initials: CA
authors.lastname: Lindberg
authors.forename: G
authors.initials: G
authors.lastname: Engström
authors.forename: M Gerhardsson
authors.initials: MG
authors.lastname: de Verdier
authors.forename: U
authors.initials: U
authors.lastname: Nihlén
authors.forename: M
authors.initials: M
authors.lastname: Anderson
authors.forename: K
authors.initials: K
authors.lastname: Forsman-Semb
authors.forename: M
authors.initials: M
authors.lastname: Svartengren
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood / Q000652:urine; D003895:Desmosine / Q000097:blood / Q000652:urine*; D005260:Female; D006801:Humans; D007524:Isodesmosine / Q000097:blood / Q000652:urine*; D008168:Lung / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000175:diagnosis* / Q000652:urine*; D012042:Registries; D012129:Respiratory Function Tests; D012680:Sensitivity and Specificity; D012907:Smoking / Q000097:blood / Q000652:urine
chemical_list: D015415:Biomarkers; D003895:Desmosine; D007524:Isodesmosine