title: [Pharmacokinetics and bioavailability of Puerarin self-microemulsion in Beagle dogs].
abstract: OBJECTIVE
  To estabolish a quantitative analysis method for pharmacokinetics and bioavailability of Puerarin self-microemulsion in Beagle dogs.
  
  
  METHODS
  A crossover design was use to detect the pharmacokinetic parameters of Puerarin self-microemulsion and suspension in Beagle dogs. The concentration of Puerarin in plasma was determined with HPLC, the pharmacokinetics parameters and bioavailability was calculated with DAS 2. 1. 1 programs.
  
  
  RESULTS
  T(max) of Puerarin self-microemulsion and suspension were 3.0 h and 2.0 h, C(max) were 2.14 mg/L and 1.061 mg/L, AUC(0-24) were 10.642 mg h/L and 3 mg x h/L, respectively. The bioavailability of Puerarin self-microemulsion relative to Puerarin suspension were 354.73%.
  
  
  CONCLUSIONS
  Puerarin self-microemulsion can significantly improve the bioavailability in Beagle dogs.
authors.affiliation: Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China. chenzhenyu2000@yahoo.com.cn
authors.forename: Xiao-Xin
authors.initials: XX
authors.lastname: Chen
authors.forename: Su
authors.initials: S
authors.lastname: Yuan
authors.forename: Geng
authors.initials: G
authors.lastname: Li
authors.forename: You-Ya
authors.initials: YY
authors.lastname: Liang
authors.forename: Xiu
authors.initials: X
authors.lastname: Zhou
authors.forename: Cheng-Shi
authors.initials: CS
authors.lastname: Xie
authors.forename: Chao-Feng
authors.initials: CF
authors.lastname: Long
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D016503:Drug Delivery Systems / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics; D004655:Emulsions; D007887:Fabaceae / Q000737:chemistry*; D005260:Female; D007529:Isoflavones / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D023421:Models, Animal; D010599:Pharmacokinetics; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D004365:Drugs, Chinese Herbal; D004655:Emulsions; D007529:Isoflavones; D012997:Solvents; D014665:Vasodilator Agents; C033607:puerarin