title: Suppression of cellular transformation by poly (A) binding protein interacting protein 2 (Paip2).
abstract: Controlling translation is crucial for the homeostasis of a cell. Its deregulation can facilitate the development and progression of many diseases including cancer. Poly (A) binding protein interacting protein 2 (Paip2) inhibits efficient initiation of translation by impairing formation of the necessary closed loop of mRNA. The over production of Paip2 in the presence of a constitutively active form of hRas(V12) can reduce colony formation in a semi-solid matrix and focus formation on a cell monolayer. The ability of Paip2 to bind to Pabp is required to suppress the transformed phenotype mediated by hRas(V12). These observations indicate that Paip2 is able to function as a tumor suppressor.
authors.affiliation: Department of Microbiology & Immunology, Columbia University College of Physicians & Surgeons, New York, New York, United States of America. amy.abrosenfeld@gmail.com
authors.forename: Amy B
authors.initials: AB
authors.lastname: Rosenfeld
mesh_terms: D000818:Animals; D002453:Cell Cycle; D002471:Cell Transformation, Neoplastic / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D041681:NIH 3T3 Cells; D017434:Protein Structure, Tertiary; D016601:RNA-Binding Proteins; D012097:Repressor Proteins / Q000737:chemistry / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000737:chemistry / Q000378:metabolism*
chemical_list: C569621:Paip2 protein, mouse; D016601:RNA-Binding Proteins; D012097:Repressor Proteins; D025521:Tumor Suppressor Proteins