title: Eukaryotic 5S rRNA biogenesis.
abstract: The ribosome is a large complex containing both protein and RNA which must be assembled in a precise manner to allow proper functioning in the critical role of protein synthesis. 5S rRNA is the smallest of the RNA components of the ribosome, and although it has been studied for decades, we still do not have a clear understanding of its function within the complex ribosome machine. It is the only RNA species that binds ribosomal proteins prior to its assembly into the ribosome. Its transport into the nucleolus requires this interaction. Here we present an overview of some of the key findings concerning the structure and function of 5S rRNA and how its association with specific proteins impacts its localization and function.
authors.affiliation: Department of Microbiology and Immunology, University at Buffalo, Buffalo, NY, USA.
authors.forename: Martin
authors.initials: M
authors.lastname: Ciganda
authors.forename: Noreen
authors.initials: N
authors.lastname: Williams
mesh_terms: D000818:Animals; D001483:Base Sequence; D003593:Cytoplasm / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D012323:RNA Processing, Post-Transcriptional; D012341:RNA, Ribosomal, 5S / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics; D016601:RNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D012269:Ribosomal Proteins / Q000737:chemistry / Q000378:metabolism; D012270:Ribosomes / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D035582:Transcription Factor TFIIIA / Q000737:chemistry / Q000378:metabolism
chemical_list: D012341:RNA, Ribosomal, 5S; D016601:RNA-Binding Proteins; D012269:Ribosomal Proteins; D035582:Transcription Factor TFIIIA