title: An aryl-phosphonate appended macrocyclic platform for lanthanide based bimodal imaging agents.
abstract: Four ligand systems have been prepared whose characteristics are well suited to the design of bimodal MRI and luminescence probes. The lanthanide complexes display high relaxivities and luminescence quantum yields. These properties are retained at higher magnetic fields and in a range of competitive environments including model extracellular medium and cultured cells.
authors.affiliation: Department for Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Spemannstr. 38, 72076 Tübingen, Germany.
authors.forename: Matteo P
authors.initials: MP
authors.lastname: Placidi
authors.forename: Jörn
authors.initials: J
authors.lastname: Engelmann
authors.forename: Louise S
authors.initials: LS
authors.lastname: Natrajan
authors.forename: Nikos K
authors.initials: NK
authors.lastname: Logothetis
authors.forename: Goran
authors.initials: G
authors.lastname: Angelovski
mesh_terms: D016475:3T3 Cells; D000818:Animals; D003287:Contrast Media / Q000737:chemistry* / Q000378:metabolism; D005063:Europium / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry* / Q000378:metabolism; D008024:Ligands; D049449:Luminescence; D049408:Luminescent Agents / Q000737:chemistry* / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D063065:Organophosphonates / Q000737:chemistry* / Q000378:metabolism; D013725:Terbium / Q000737:chemistry*
chemical_list: D003287:Contrast Media; D008024:Ligands; D049408:Luminescent Agents; D063065:Organophosphonates; D013725:Terbium; D005063:Europium; D005682:Gadolinium