title: Site-selective, cleavable linkers: quality control and the characterization of small molecules on microelectrode arrays.
abstract: A "safety-catch" linker strategy has been used to release a portion of the products of a Diels-Alder reaction conducted on a microelectrode array for characterization of stereochemistry. The attachment and cleavage of organic compounds from the surface of selected electrodes in the array can be accomplished by site-selective generation of base or acid at the electrode. It was found that the surface of the array had a minor influence on the stereochemistry of the Diels-Alder reaction, leading to slightly more of the exo-product relative to a similar solution-phase reaction.
authors.affiliation: Department of Chemistry, Washington University, St. Louis, Missouri 63130, United States.
authors.forename: Bo
authors.initials: B
authors.lastname: Bi
authors.forename: Richard Y-C
authors.initials: RY
authors.lastname: Huang
authors.forename: Karl
authors.initials: K
authors.lastname: Maurer
authors.forename: Ceng
authors.initials: C
authors.lastname: Chen
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Moeller
mesh_terms: D003432:Cross-Linking Reagents / Q000737:chemistry*; D046228:Microarray Analysis / Q000379:methods*; D008839:Microelectrodes; D015394:Molecular Structure; D036103:Nanotechnology; D009930:Organic Chemicals / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D003432:Cross-Linking Reagents; D009930:Organic Chemicals; D012996:Solutions