title: A meta-analysis of eNOS and ACE gene polymorphisms and risk of pre-eclampsia in women.
abstract: A meta-analyses of endothelial nitric oxide synthase (eNOS) and angiotensin-converting enzyme (ACE) gene polymorphisms in pre-eclampsia was performed. We shortlisted 33 studies (17 for ACE; 16 for eNOS gene polymorphisms), of which 29 articles (16 for ACE and 15 for eNOS) were analysed. Overall, 1,620 cases with pre-eclampsia and 2,158 controls were analysed for intron 16 insertion-deletion polymorphism in ACE gene. A total of 1,610 subjects with pre-eclampsia and 2,875 controls were analysed for the Glu298Asp in eNOS gene. Overall, the random-effects odds ratio (OR) with Glu298Asp in eNOS gene was 0.958 (95% confidence intervals, CI 0.747-1.228, p > 0.05), and for the insertion-deletion/ACE polymorphism was 0.987 (95% CI 0.698-1.395, p > 0.05). Significant heterogeneity was observed in the studies that evaluated polymorphisms in ACE (Q value = 55.6; I(2) = 73; p value = 0.000); and eNOS (Q value = 37.2; I(2) = 62.4; p value = 0.001) polymorphisms. No significant risk of pre-eclampsia was observed in both eNOS and ACE genes with these polymorphisms.
authors.affiliation: Jawaharlal Nehru Institute of Advanced Studies (JNIAS), Secunderabad, India. afzalshaik@gmail.com
authors.forename: A P
authors.initials: AP
authors.lastname: Shaik
authors.forename: A
authors.initials: A
authors.lastname: Sultana
authors.forename: V K
authors.initials: VK
authors.lastname: Bammidi
authors.forename: K
authors.initials: K
authors.lastname: Sampathirao
authors.forename: K
authors.initials: K
authors.lastname: Jamil
mesh_terms: D005260:Female; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D016254:Mutagenesis, Insertional / Q000235:genetics; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D016017:Odds Ratio; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy
chemical_list: D052250:Nitric Oxide Synthase Type III; D007703:Peptidyl-Dipeptidase A