title: Early hospital care of severe traumatic brain injury.
abstract: Head injury is one of the major causes of trauma-related morbidity and mortality in all age groups in the United Kingdom, and anaesthetists encounter this problem in many areas of their work. Despite a better understanding of the pathophysiological processes following traumatic brain injury and a wealth of research, there is currently no specific treatment. Outcome remains dependant on basic clinical care: management of the patient's airway with particular attention to preventing hypoxia; avoidance of the extremes of lung ventilation; and the maintenance of adequate cerebral perfusion, in an attempt to avoid exacerbating any secondary injury. Hypertonic fluids show promise in the management of patients with raised intracranial pressure. Computed tomography scanning has had a major impact on the early identification of lesions amenable to surgery, and recent guidelines have rationalised its use in those with less severe injuries. Within critical care, the importance of controlling blood glucose is becoming clearer, along with the potential beneficial effects of hyperoxia. The major improvement in outcome reflects the use of protocols to guide resuscitation, investigation and treatment and the role of specialist neurosciences centres in caring for these patients. Finally, certain groups are now recognised as being at greater risk, in particular the elderly, anticoagulated patient.
authors.affiliation: Salford Royal NHS Foundation Trust, Salford, UK. richard.protheroe@srft.nhs.uk
authors.forename: R T
authors.initials: RT
authors.lastname: Protheroe
authors.forename: C L
authors.initials: CL
authors.lastname: Gwinnutt
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D001930:Brain Injuries / Q000503:physiopathology / Q000628:therapy*; D005440:Fluid Therapy; D006801:Humans; D007427:Intracranial Pressure; D012121:Respiration, Artificial; D014057:Tomography, X-Ray Computed
chemical_list: D001786:Blood Glucose