title: High cut-off haemodialysis induces remission of recurrent idiopathic focal segmental glomerulosclerosis after renal transplantation but is no alternative to plasmapheresis.
abstract: A 26-year-old male experienced a recurrence of idiopathic focal segmental glomerulosclerosis (iFSGS) after his second renal transplant. Reduction of proteinuria was rapidly induced by plasmapheresis (PP) and the patient has remained in remission with a once-weekly PP regimen, which has now been continued for >3½ years. We were also able to induce remission of iFSGS in this patient by treatment with high cut-off haemodialysis using the Theralite™ dialyser. This observation lends support for the pathophysiological role of an as yet unknown, circulating glomerular filtration barrier permeability factor with an estimated weight of between 30 and 50 kDa.
authors.affiliation: Division of Nephrology and Renal Transplantation, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Iris
authors.initials: I
authors.lastname: Noorlander
authors.forename: Dennis A
authors.initials: DA
authors.lastname: Hesselink
authors.forename: Marike
authors.initials: M
authors.lastname: Wabbijn
authors.forename: Michiel G H
authors.initials: MG
authors.lastname: Betjes