title: Identification and pathogenicity of a natural reassortant between a very virulent serotype 1 infectious bursal disease virus (IBDV) and a serotype 2 IBDV.
abstract: Infectious bursal disease virus (IBDV) causes an economically important, immunosuppressive disease in chickens. There are two serotypes of the virus that contain a bi-segmented double-stranded RNA genome. In December 2008, the first very virulent (vv)IBDV was identified in California, USA and in 2009 we isolated reassortant viruses in two different locations. Genome segment A of these reassortants was typical of vvIBDV serotype 1 but genome segment B was most similar to IBDV serotype 2. The CA-K785 reassortant caused 20% mortality in chickens but no morbidity or mortality in commercial turkey poults despite being infectious. There have been previous reports of natural reassortants between vvIBDV and other serotype 1 strains, but a natural reassortant between IBDV serotypes 1 and 2 has not been described. The apparent reassorting of California vvIBDV with an endemic serotype 2 virus indicates a common host and suggests vvIBDV may have entered California earlier than originally thought.
authors.affiliation: Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA. Jackwood.2@osu.edu
authors.forename: Daral J
authors.initials: DJ
authors.lastname: Jackwood
authors.forename: Susan E
authors.initials: SE
authors.lastname: Sommer-Wagner
authors.forename: Beate M
authors.initials: BM
authors.lastname: Crossley
authors.forename: Simone T
authors.initials: ST
authors.lastname: Stoute
authors.forename: Peter R
authors.initials: PR
authors.lastname: Woolcock
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Charlton
mesh_terms: D000818:Animals; D001483:Base Sequence; D018175:Birnaviridae Infections / Q000401:mortality / Q000473:pathology / Q000662:veterinary / Q000821:virology; D002645:Chickens / Q000821:virology; D007243:Infectious bursal disease virus / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity; D011201:Poultry Diseases / Q000453:epidemiology / Q000821:virology; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics; D016865:Reassortant Viruses / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity; D011995:Recombination, Genetic; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017423:Sequence Analysis, RNA; D012703:Serotyping; D014422:Turkeys / Q000821:virology
chemical_list: D012367:RNA, Viral