title: REFLEX, a social-cognitive group treatment to improve insight in schizophrenia: study protocol of a multi-center RCT.
abstract: BACKGROUND
  Insight is impaired in a majority of people with schizophrenia. Impaired insight is associated with poorer outcomes of the disorder. Based on existing literature, we developed a model that explains which processes may possibly play a role in impaired insight. This model was the starting point of the development of REFLEX: a brief psychosocial intervention to improve insight in schizophrenia. REFLEX is a 12-sessions group training, consisting of three modules of four sessions each. Modules in this intervention are: "coping with stigma", "you and your personal narrative", and "you in the present".
  
  
  METHODS
  REFLEX is currently evaluated in a multicenter randomized controlled trial. Eight mental health institutions in the Netherlands participate in this evaluation. Patients are randomly assigned to either REFLEX or an active control condition, existing of cognitive remediation exercises in a group. In a subgroup of patients, fMRI scans are made before and after training in order to assess potential haemodynamic changes associated with the effects of the training.
  
  
  CONCLUSIONS
  REFLEX is one of the few interventions aiming specifically to improving insight in schizophrenia and has potential value for improving insight. Targeting insight in schizophrenia is a complex task, that comes with several methodological issues. These issues are addressed in the discussion of this paper.
  
  
  BACKGROUND
  Current Controlled Trials: ISRCTN50247539.
authors.affiliation: Dept. of Psychotic Disorders, GGZ-Drenthe, Dennenweg 9, 9404 LA, Assen, The Netherlands. g.h.m.pijnenborg@rug.nl
authors.forename: G H M
authors.initials: GH
authors.lastname: Pijnenborg
authors.forename: Mark
authors.initials: M
authors.lastname: Van der Gaag
authors.forename: Claudi L H
authors.initials: CL
authors.lastname: Bockting
authors.forename: Lisette
authors.initials: L
authors.lastname: Van der Meer
authors.forename: André
authors.initials: A
authors.lastname: Aleman
mesh_terms: D001931:Brain Mapping / Q000379:methods / Q000523:psychology; D002985:Clinical Protocols; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D032882:Comprehension; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000523:psychology; D011615:Psychotherapy, Group / Q000379:methods*; D012559:Schizophrenia / Q000628:therapy*; D012565:Schizophrenic Psychology