title: The development of two different malignancies in a patient with large congenital melanocytic nevus.
abstract: Patients with large congenital melanocytic nevus (LCMN) have a high risk of developing malignant melanoma (MM) and other malignancies. We report a case of a mesenchymal malignancy that best fit the diagnosis of a malignant peripheral nerve sheath tumor and subsequent development of a MM developing from a LCMN. There are no previous reports of a second primary malignant neoplasm arising from a LCMN.
authors.affiliation: Melanoma Unit, Hospital Santa Rita, Complexo Hospitalar Santa Casa de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Tadeu
authors.initials: T
authors.lastname: Ambros
authors.affiliation: Melanoma Unit/Pathology, Hospital Santa Rita, Complexo Hospitalar Santa Casa de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Roque
authors.initials: R
authors.lastname: Furian
authors.affiliation: Melanoma Unit/Oncology Surgery, Hospital Santa Rita, Complexo Hospitalar Santa Casa de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Felice
authors.initials: F
authors.lastname: Riccardi
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007372:Interferons / Q000627:therapeutic use; D007680:Kidney Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008545:Melanoma / Q000151:congenital* / Q000556:secondary / Q000601:surgery; D009378:Neoplasms, Multiple Primary / Q000151:congenital* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D020752:Neurocutaneous Syndromes / Q000151:congenital / Q000188:drug therapy / Q000473:pathology; D009508:Nevus, Pigmented / Q000151:congenital* / Q000188:drug therapy / Q000473:pathology; D012878:Skin Neoplasms / Q000151:congenital* / Q000188:drug therapy / Q000473:pathology; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D014750:Vincristine; D003520:Cyclophosphamide; D007372:Interferons