title: mTOR signaling in disease.
abstract: The target of rapamycin (TOR) is a highly conserved serine/threonine kinase and a central controller of cell growth, metabolism and aging. Mammalian TOR (mTOR) is activated in response to nutrients, growth factors and cellular energy. Dysregulated mTOR signaling has been implicated in major disease. Here we review recent findings on the role of mTOR in cancer, metabolic disorders, neurological diseases, and inflammation.
authors.affiliation: Biozentrum, University of Basel, CH4056 Basel, Switzerland.
authors.forename: Eva
authors.initials: E
authors.lastname: Dazert
authors.forename: Michael N
authors.initials: MN
authors.lastname: Hall
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D004195:Disease Models, Animal; D006801:Humans; D008322:Mammals / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases