title: Mediterranean wild plants reduce postprandial platelet aggregation in patients with metabolic syndrome.
abstract: Postprandial platelet hyperactivity and aggregation play a crucial role in the pathogenesis of metabolic syndrome. The purpose of the present study was to evaluate the effect of boiled wild plants consumption on the postprandial platelet aggregation in metabolic syndrome patients. Patients consumed 5 meals in a random order (ie, 4 wild plant meals, namely, Reichardia picroides [RP], Cynara cardunculus, Urospermum picroides [UP], and Chrysanthemum coronarium, and a control meal, which contained no wild plants). Several biochemical indices as well as platelet activating factor (PAF)- and adenosine diphosphate-induced ex vivo platelet aggregation were measured postprandially. Moreover, the ability of plants extract to inhibit rabbit platelet aggregation was tested in vitro. The consumption of RP and UP meals significantly reduced ex vivo adenosine diphosphate-induced postprandial platelet aggregation compared with the control meal. The consumption of UP meals significantly reduced the ex vivo PAF-induced platelet aggregation postprandially. Both UP and RP extracts significantly inhibited PAF-induced rabbit platelet aggregation in vitro. Wild plants consumption reduced postprandial platelet hyperaggregability of metabolic syndrome patients, which may account for their healthy effects.
authors.affiliation: Department of Nutrition-Dietetics, Harokopio University, Athens, 17671 Greece.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Fragopoulou
authors.forename: Paraskevi
authors.initials: P
authors.lastname: Detopoulou
authors.forename: Tzortzis
authors.initials: T
authors.lastname: Nomikos
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Pliakis
authors.forename: Demosthenes B
authors.initials: DB
authors.lastname: Panagiotakos
authors.forename: Smaragdi
authors.initials: S
authors.lastname: Antonopoulou
mesh_terms: D000367:Age Factors; D000818:Animals; D000886:Anthropometry; D001794:Blood Pressure / Q000502:physiology; D001827:Body Height; D001835:Body Weight / Q000502:physiology; D031202:Chrysanthemum / Q000737:chemistry; D003296:Cooking; D031942:Cynara / Q000737:chemistry; D006115:Greece; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology; D019083:Mediterranean Region; D024821:Metabolic Syndrome / Q000097:blood* / Q000178:diet therapy; D010945:Plants, Edible / Q000737:chemistry*; D010974:Platelet Aggregation / Q000502:physiology*; D019518:Postprandial Period; D011817:Rabbits; D012907:Smoking / Q000009:adverse effects; D013927:Thrombosis / Q000453:epidemiology / Q000517:prevention & control; D049629:Waist-Hip Ratio