title: Non-fragrance allergens in specific cosmetic products.
abstract: OBJECTIVE
  Reports about the nature of the ingredients responsible for allergic contact dermatitis caused by specific cosmetic products are scarce.
  
  
  METHODS
  Between January 2000 and December 2010, the specific cosmetic products having caused allergic contact dermatitis, as well as the individual allergenic cosmetic ingredients present in them, were recorded by use of a standardized form.
  
  
  RESULTS
  Among 11 different categories of cosmetic product, skin care products, followed by hair care and body-cleansing products, were most often involved. The presence of the allergenic ingredient(s) in a specific cosmetic product was confirmed according to the ingredient label in 959 of 1448 records. Six hundred and twenty-one of 959 concerned non-fragrance components, preservatives being responsible for 58% of them. Reactions to formaldehyde and formaldehyde-releasers were most often correlated with body-cleansing products, particularly 2-bromo-2-nitropropane-1,3-diol and skin care products. They were followed by the methylchloroisothiazolinone/methylisothiazolinone mixture, most frequently found as allergens in hair care and intimate hygiene products, and facial cleansers (in the last category together with diazolidinyl urea). Octocrylene was by far the most frequent (photo)allergen in sun care products.
  
  
  CONCLUSIONS
  This study provides information on the presence and frequency of allergens in specific causal cosmetic products.
authors.affiliation: Clínica Universitária de Dermatologia, Hospital de Santa Maria, 1649-028 Lisboa, Portugal.
authors.forename: Ana Rita
authors.initials: AR
authors.lastname: Travassos
authors.forename: Lieve
authors.initials: L
authors.lastname: Claes
authors.forename: Lies
authors.initials: L
authors.lastname: Boey
authors.forename: Jacques
authors.initials: J
authors.lastname: Drieghe
authors.forename: An
authors.initials: A
authors.lastname: Goossens
mesh_terms: D000179:Acrylates / Q000009:adverse effects; D000485:Allergens / Q000009:adverse effects*; D000975:Antioxidants / Q000009:adverse effects; D003358:Cosmetics / Q000009:adverse effects* / Q000737:chemistry*; D003430:Cross-Sectional Studies; D016208:Databases, Factual; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D045703:Emulsifying Agents / Q000009:adverse effects; D005026:Ethylene Glycols / Q000009:adverse effects; D005557:Formaldehyde / Q000009:adverse effects; D006801:Humans; D006827:Hydantoins / Q000009:adverse effects; D008689:Methacrylates / Q000009:adverse effects; D008709:Methenamine / Q000009:adverse effects / Q000031:analogs & derivatives; D009532:Nickel / Q000009:adverse effects; D010226:Parabens / Q000009:adverse effects; D010936:Plant Extracts / Q000009:adverse effects; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects*; D011409:Propylene Glycols / Q000009:adverse effects; D013473:Sunscreening Agents / Q000009:adverse effects; D013844:Thiazoles / Q000009:adverse effects; D014508:Urea / Q000009:adverse effects / Q000031:analogs & derivatives
chemical_list: D000179:Acrylates; D000485:Allergens; D000975:Antioxidants; D003358:Cosmetics; D045703:Emulsifying Agents; D005026:Ethylene Glycols; D006827:Hydantoins; D008689:Methacrylates; D010226:Parabens; D010936:Plant Extracts; D011310:Preservatives, Pharmaceutical; D011409:Propylene Glycols; D013473:Sunscreening Agents; D013844:Thiazoles; D005557:Formaldehyde; C088673:octocrylene; C006827:bronopol; D009532:Nickel; D014508:Urea; C056057:1,3-dimethylol-5,5-dimethylhydantoin; C011421:5-chloro-2-methyl-4-isothiazolin-3-one; C018375:quaternium-15; C044982:diazolidinylurea; C005398:phenoxyethanol; D008709:Methenamine; C006048:imidazolidinyl urea