title: [Interaction of N-methyl-D-aspartate and Dopamine D1 receptors in modulation of passive avoidance extinction at mice with depressive-like state].
abstract: The effect of activation of N-methyl-D-aspartate (D-cycloserine) and dopamine D1 (SKF 38393) receptors on learning and extinction of the passive avoidance response in mice under normal conditions and after formation of "behavioural despair" is studied. The data on ineffectiveness of D-cycloserine and SKF 38393 on training a conditional reflex were obtained. In mice with the normal state, SKF 38393 did not alter the dynamics of extinction, and D-cycloserine facilitated a more rapid decline in retrieval of memory trace when testing without penalty. On exposure to D-cycloserine + SKF 38393 injection, dynamics of extinction was similar to that under the action of D-cycloserine. In mice with the reaction of "behavioral despair", D-cycloserine and SKF 38393 reduced the deficit of the passive avoidance extinction typical for "depressed" animals without drugs. With simultaneous activation of NMDA and D1 receptors we observed acceleration of the extinction start and development of complete extinction of the memory trace about pain impact as compared with single injections of D-cycloserine and SKF 38393.
authors.forename: N I
authors.initials: NI
authors.lastname: Dubrovina
authors.forename: D V
authors.initials: DV
authors.lastname: Zinov'eva
mesh_terms: D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology; D003523:Cycloserine / Q000494:pharmacology*; D003863:Depression / Q000188:drug therapy / Q000503:physiopathology; D003866:Depressive Disorder / Q000188:drug therapy* / Q000503:physiopathology; D004298:Dopamine / Q000378:metabolism; D018491:Dopamine Agonists / Q000494:pharmacology; D005108:Extinction, Psychological / Q000187:drug effects* / Q000502:physiology; D007274:Injections, Intraperitoneal; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D023421:Models, Animal; D016202:N-Methylaspartate / Q000378:metabolism; D020239:Receptor Cross-Talk / Q000502:physiology; D017447:Receptors, Dopamine D1 / Q000819:agonists* / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000819:agonists* / Q000378:metabolism
chemical_list: D018491:Dopamine Agonists; D017447:Receptors, Dopamine D1; D016194:Receptors, N-Methyl-D-Aspartate; D016202:N-Methylaspartate; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D003523:Cycloserine; D004298:Dopamine