title: Enzymatic enantiomeric resolution of phenylethylamines structurally related to amphetamine.
abstract: Both enantiomers of several phenylethylamines, structurally related to amphetamine, have been prepared in good yields and excellent enantiomeric purity by enzymatic kinetic resolution using CAL-B and ethyl methoxyacetate as the acyl donor. In the case of the 4-hydroxyderivative of amphetamine (compound 4i), the S enantiomer racemized possibly in a dynamic kinetic resolution (DKR) under the enzymatic conditions used.
authors.affiliation: Department of Biological Chemistry and Molecular Modelling, IQAC (CSIC), 08034 Barcelona, Spain.
authors.forename: Lourdes
authors.initials: L
authors.lastname: Muñoz
authors.forename: Anna M
authors.initials: AM
authors.lastname: Rodriguez
authors.forename: Gloria
authors.initials: G
authors.lastname: Rosell
authors.forename: M Pilar
authors.initials: MP
authors.lastname: Bosch
authors.forename: Angel
authors.initials: A
authors.lastname: Guerrero
mesh_terms: D000661:Amphetamine / Q000737:chemistry*; D007700:Kinetics; D015394:Molecular Structure; D010627:Phenethylamines / Q000138:chemical synthesis* / Q000378:metabolism*; D013237:Stereoisomerism
chemical_list: D010627:Phenethylamines; D000661:Amphetamine