title: [Peroxynitrite effect on the haemoglobin oxygen affinity in vitro in presence of different partial pressure of carbon dioxide].
abstract: Peroxynitrite (ONOO-) besides its toxic possesses regulatory action that includes the modulation of oxygen binding properties of blood. The aim of this work was to estimate ONOO- effect on the haemoglobin oxygen affinity (HOA) in vitro in presence of different partial pressure of carbon dioxide (CO2). The ONOO- presence in venous blood in conditions of hypercapnia induced oxyhaemoglobin dissociation curve shift leftward while in hypocapnic conditions the result of a different character was obtained. The revealed effect of ONOO- is realized, possibly, through various modifications ofhaemoglobin whose formation is dependent on the CO2 pressure. The ONOO- influences the HOA in different manner that can be important in regulation of blood oxygenation in lungs and maintenance of oxygen consumption in tissues.
authors.forename: T L
authors.initials: TL
authors.lastname: Stepuro
authors.forename: V V
authors.initials: VV
authors.lastname: Zinchuk
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000097:blood*; D006454:Hemoglobins / Q000737:chemistry / Q000378:metabolism*; D006935:Hypercapnia / Q000097:blood*; D016857:Hypocapnia / Q000097:blood*; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D030421:Peroxynitrous Acid / Q000494:pharmacology; D011485:Protein Binding / Q000187:drug effects; D011817:Rabbits
chemical_list: D006454:Hemoglobins; D002245:Carbon Dioxide; D030421:Peroxynitrous Acid; D010100:Oxygen