title: Genetic associations of surfactant protein D and angiotensin-converting enzyme with lung disease in preterm neonates.
abstract: OBJECTIVE
  To replicate genetic associations with respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD) in genes related to surfactant deficiency, inflammation and infection, and the renin-angiotensin system.
  
  
  METHODS
  We examined eight candidate genes for associations with RDS and BPD in 433 preterm birth (PTB-<37 weeks) infants (251 with RDS and 134 with BPD). Both case-control and family-based analyses were performed in preterm (<37 weeks) and very preterm birth (VPTB-<32 weeks) infants.
  
  
  RESULTS
  We replicated a previous finding that rs1923537, a marker downstream of surfactant protein D (SFTPD) is associated with RDS in VPTB infants in that the T allele was overtransmitted from parents to offspring with RDS (P=8.4 × 10(-3)). We also observed the A allele of rs4351 in the angiotensin-converting enzyme (ACE) gene was overtransmitted from parents to VPTB offspring with BPD (P=9.8 × 10(-3)).
  
  
  CONCLUSIONS
  These results give further insight into the genetic risk factors for complex neonatal respiratory diseases and provide more evidence of the importance of SFTPD and ACE in the etiology of RDS and BPD, respectively.
authors.affiliation: Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
authors.forename: K K
authors.initials: KK
authors.lastname: Ryckman
authors.forename: J M
authors.initials: JM
authors.lastname: Dagle
authors.forename: K
authors.initials: K
authors.lastname: Kelsey
authors.forename: A M
authors.initials: AM
authors.lastname: Momany
authors.forename: J C
authors.initials: JC
authors.lastname: Murray
mesh_terms: D000483:Alleles; D001997:Bronchopulmonary Dysplasia / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D015331:Cohort Studies; D004247:DNA / Q000032:analysis / Q000235:genetics; D005260:Female; D018507:Gene Expression Regulation, Developmental; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007234:Infant, Premature; D007363:Intensive Care Units, Neonatal; D008297:Male; D015997:Neonatal Screening; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D011379:Prognosis; D037663:Pulmonary Surfactant-Associated Protein D / Q000235:genetics*; D012084:Renin-Angiotensin System / Q000235:genetics / Q000502:physiology; D012127:Respiratory Distress Syndrome, Newborn / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D012189:Retrospective Studies; D018570:Risk Assessment; D017678:Sex Distribution; D015996:Survival Rate
chemical_list: D037663:Pulmonary Surfactant-Associated Protein D; D004247:DNA; D007703:Peptidyl-Dipeptidase A