title: On cochlear impedances and the miscomputation of power gain.
abstract: In their article, "Measurement of cochlear power gain in the sensitive gerbil ear," Ren et al. (Nat Commun 2:216, 2011) claim to provide "the first direct experimental evidence of power amplification in the sensitive living cochlea." While we recognize the technical challenges of the experiments and appreciate the beauty of the data, the authors' analysis and interpretation of the measurements are invalid. We review the concept of impedance (i.e., the ratio of pressure to velocity) as it applies to cochlear mechanics and show that Ren et al. mistakenly equate the impedances near the basilar membrane and stapes with the impedance characteristic of an infinite, uniform tube of fluid. As a consequence of this error, Ren et al.'s measurements and analysis provide no evidence for power amplification in the cochlea. Compelling evidence for power amplification has, however, been previously provided by others.
authors.affiliation: Eaton-Peabody Laboratories, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA. shera@epl.meei.harvard.edu
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Shera
authors.forename: Elizabeth S
authors.initials: ES
authors.lastname: Olson
authors.forename: John J
authors.initials: JJ
authors.lastname: Guinan
mesh_terms: D000158:Acoustic Impedance Tests / Q000379:methods* / Q000592:standards*; D000818:Animals; D001489:Basilar Membrane / Q000502:physiology*; D001696:Biomechanical Phenomena / Q000502:physiology; D001703:Biophysics / Q000379:methods / Q000592:standards; D004710:Endolymph / Q000502:physiology; D005849:Gerbillinae; D008954:Models, Biological; D009925:Organ of Corti / Q000502:physiology*; D011312:Pressure; D015203:Reproducibility of Results; D013199:Stapes / Q000502:physiology