title: [Clinical application of low-molecular-weight heparin (Fraxiparine) in rescuing venous crisis of island skin flap].
abstract: OBJECTIVE
  To evaluate the clinical efficacy of low molecular weight heparin (Fraxiparine) in rescuing venous crisis of island skin flap.
  
  
  METHODS
  Of the 73 patients with venous crisis of island skin flap, 47 received subcutaneous injection of low-molecular-weight heparin (group I) and 26 were treated with phlebotomy, local compression and topical application of unfractionated heparin solution gauze (group II).
  
  
  RESULTS
  The flap survival ratio was (88.46∓8.64)% in group I and (38.37∓6.53)% in group II (P<0.001). At 0, 2, and 4 h after injection of low-molecular-weight heparin, the activated partial thromboplastin time (APTT) was obviously delayed (24.28∓6.71, 41.35∓7.64 and 32.34∓6.35, respectively, P<0.01), FXa:C level was significantly decreased (152.4∓30.7, 65.8∓24.4 and 83.4∓18.4, respectively, P<0.01), while FIIa:C level underwent no obvious alterations (155.70∓31.61, 143.20∓24.75, and 143.4∓23.35, respectively, P=NS).
  
  
  CONCLUSIONS
  Fraxiparine has good antithrombotic efficacy in rescuing venous crisis of island skin flap without adverse effect on systemic coagulation.
authors.affiliation: Department of Burn Surgery, Guangdong Provincial People's Hospital, Guangzhou, China. xiongbing1@hotmail.com
authors.forename: Bing
authors.initials: B
authors.lastname: Xiong
authors.forename: Hua-de
authors.initials: HD
authors.lastname: Chen
authors.forename: Wen
authors.initials: W
authors.lastname: Lai
authors.forename: Shao-yi
authors.initials: SY
authors.lastname: Zheng
authors.forename: Hui
authors.initials: H
authors.lastname: Gao
authors.forename: Hui-ning
authors.initials: HN
authors.lastname: Bian
authors.forename: Zu-an
authors.initials: ZA
authors.lastname: Liu
authors.forename: Zhi-feng
authors.initials: ZF
authors.lastname: Huang
authors.forename: Li-jun
authors.initials: LJ
authors.lastname: Wei
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017762:Nadroparin / Q000627:therapeutic use*; D013524:Surgical Flaps / Q000009:adverse effects*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D017762:Nadroparin