title: Structure-function relationships using the Cirrus spectral domain optical coherence tomograph and standard automated perimetry.
abstract: OBJECTIVE
  To evaluate the relationship between glaucomatous structural damage assessed by the Cirrus Spectral Domain OCT (SDOCT) and functional loss as measured by standard automated perimetry (SAP).
  
  
  METHODS
  Four hundred twenty-two eyes (78 healthy, 210 suspects, 134 glaucomatous) of 250 patients were recruited from the longitudinal Diagnostic Innovations in Glaucoma Study and from the African Descent and Glaucoma Evaluation Study. All eyes underwent testing with the Cirrus SDOCT and SAP within a 6-month period. The relationship between parapapillary retinal nerve fiber layer thickness (RNFL) sectors and corresponding topographic SAP locations was evaluated using locally weighted scatterplot smoothing and regression analysis. SAP sensitivity values were evaluated using both linear as well as logarithmic scales. We also tested the fit of a model (Hood) for structure-function relationship in glaucoma.
  
  
  RESULTS
  Structure was significantly related to function for all but the nasal thickness sector. The relationship was strongest for superotemporal RNFL thickness and inferonasal sensitivity (R(2)=0.314, P<0.001). The Hood model fitted the data relatively well with 88% of the eyes inside the 95% confidence interval predicted by the model.
  
  
  CONCLUSIONS
  RNFL thinning measured by the Cirrus SDOCT was associated with correspondent visual field loss in glaucoma.
authors.affiliation: Hamilton Glaucoma Center, Department of Ophthalmology, University of California San Diego, La Jolla, CA 92093, USA.
authors.forename: Mauro T
authors.initials: MT
authors.lastname: Leite
authors.forename: Linda M
authors.initials: LM
authors.lastname: Zangwill
authors.forename: Robert N
authors.initials: RN
authors.lastname: Weinreb
authors.forename: Harsha L
authors.initials: HL
authors.lastname: Rao
authors.forename: Luciana M
authors.initials: LM
authors.lastname: Alencar
authors.forename: Felipe A
authors.initials: FA
authors.lastname: Medeiros
mesh_terms: D000368:Aged; D001369:Axons / Q000473:pathology*; D003430:Cross-Sectional Studies; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000175:diagnosis / Q000503:physiopathology; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014065:Tonometry, Ocular; D014786:Vision Disorders / Q000503:physiopathology*; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology*