title: Enantioselective synthesis of 4-substituted 4,5-dihydro-1H-[1,5]benzodiazepin-2(3H)-ones by the Lewis base-catalyzed hydrosilylation.
abstract: Enantioselective synthesis of 4-substituted 4,5-dihydro-1H-[1,5]benzodiazepin-2(3H)-ones has been accomplished through chiral Lewis base-catalyzed hydrosilylation. The corresponding products were obtained in excellent yields (up to 99%) and enantioselectivities (up to 98%). The absolute configuration of product 3n has been determined as S by X-ray crystallographic analysis.
authors.affiliation: Key Laboratory for Asymmetric Synthesis and Chiraltechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Chen
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Zheng
authors.forename: Chang
authors.initials: C
authors.lastname: Shu
authors.forename: Weicheng
authors.initials: W
authors.lastname: Yuan
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Zhang
mesh_terms: D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D058115:Lewis Bases / Q000737:chemistry*; D015394:Molecular Structure; D012821:Silanes / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D058115:Lewis Bases; D012821:Silanes; D001569:Benzodiazepines