title: Chromo-fluorogenic detection of aldehydes with a rhodamine based sensor featuring an intramolecular deoxylactam.
abstract: A chromogenic and fluorogenic detection of aldehydes was achieved via analyte triggered opening of the deoxylactam of N-(rhodamine B)-deoxylactam-ethylenediamine (dRB-EDA). The utility of the sensor was demonstrated by fluorescent labeling of aldehyde-displaying sialoproteins on cell surfaces.
authors.affiliation: Department of Chemical Biology, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, China 361005.
authors.forename: Zhu
authors.initials: Z
authors.lastname: Li
authors.forename: Zhongwei
authors.initials: Z
authors.lastname: Xue
authors.forename: Zhisheng
authors.initials: Z
authors.lastname: Wu
authors.forename: Jiahuai
authors.initials: J
authors.lastname: Han
authors.forename: Shoufa
authors.initials: S
authors.lastname: Han
mesh_terms: D000447:Aldehydes / Q000032:analysis*; D000818:Animals; D002460:Cell Line; D005029:Ethylenediamines / Q000737:chemistry; D005347:Fibroblasts / Q000166:cytology; D005456:Fluorescent Dyes / Q000032:analysis / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D006001:Glycoconjugates / Q000032:analysis*; D047029:Lactams, Macrocyclic / Q000138:chemical synthesis* / Q000378:metabolism; D051379:Mice; D018613:Microscopy, Confocal; D015394:Molecular Structure; D010504:Periodic Acid / Q000737:chemistry; D012235:Rhodamines / Q000032:analysis* / Q000737:chemistry; D012795:Sialoglycoproteins / Q000032:analysis*; D013050:Spectrometry, Fluorescence; D013194:Staining and Labeling / Q000379:methods*
chemical_list: D000447:Aldehydes; D005029:Ethylenediamines; D005456:Fluorescent Dyes; D006001:Glycoconjugates; D047029:Lactams, Macrocyclic; D012235:Rhodamines; D012795:Sialoglycoproteins; D010504:Periodic Acid; C031234:ethylenediamine; C009288:metaperiodate; C029773:rhodamine B