title: Local translation of mRNAs in neural development.
abstract: Growing axons encounter numerous developmental signals to which they must promptly respond in order to properly form complex neural circuitry. In the axons, these signals are often transduced into a local increase or decrease in protein levels. Contrary to the traditional view that the cell bodies are the exclusive source of axonal proteins, it is becoming increasingly clear not only that de novo protein synthesis takes place in axons, but also that it is required for the axons to respond to certain signals. Here we review the current knowledge of local mRNA translation in developing neurons with a special focus on protein synthesis occurring in axons and growth cones.
authors.affiliation: Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
authors.forename: Hosung
authors.initials: H
authors.lastname: Jung
authors.forename: Christine E
authors.initials: CE
authors.lastname: Holt
mesh_terms: D000818:Animals; D006801:Humans; D008954:Models, Biological; D055495:Neurogenesis / Q000235:genetics* / Q000502:physiology; D009474:Neurons / Q000378:metabolism / Q000502:physiology*; D017729:Presynaptic Terminals / Q000378:metabolism; D014176:Protein Biosynthesis / Q000235:genetics / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
chemical_list: D012333:RNA, Messenger