title: Increasing the antioxidant content of food: a personal view on whether this is possible or desirable.
abstract: A commonly held belief is that higher intake of antioxidants will promote better health through enhanced antioxidant status and lowered oxidative stress. However, the benefits of antioxidant-rich foods have not been reproduced in supplementation trials with pure antioxidants. This has driven research and commercial interest in foods, including traditional foods and their components, with enhanced antioxidant content and improved antioxidant bioavailability, which in many cases is very low. In this paper, evidence for the health benefits of antioxidant-rich foods and methods to increase the antioxidant content and bioavailability of food antioxidants are reviewed briefly, and the concept that increased food antioxidant content/intake per se is beneficial is examined from a cautionary perspective, considering issues of low bioavailability, rapid catabolism, biotransformation and the paradoxical pro-oxidant effects of dietary antioxidants.
authors.affiliation: Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Kowloon, Hong Kong. htbenzie@inet.polyu.edu.hk
authors.forename: Iris F F
authors.initials: IF
authors.lastname: Benzie
authors.forename: Sissi
authors.initials: S
authors.lastname: Wachtel-Galor
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage* / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use; D019587:Dietary Supplements / Q000009:adverse effects / Q000032:analysis; D055317:Evidence-Based Practice; D005527:Food, Fortified / Q000009:adverse effects / Q000032:analysis*; D006293:Health Promotion / Q000379:methods*; D006801:Humans; D009753:Nutritive Value; D016877:Oxidants / Q000009:adverse effects; D010084:Oxidation-Reduction; D018384:Oxidative Stress
chemical_list: D000975:Antioxidants; D016877:Oxidants