title: Sultone opening with [18F]fluoride: an efficient 18F-labelling strategy for PET imaging.
abstract: Sultones were subject to ring opening by nucleophilic attack with [(18)F]fluoride to afford easily purified (18)F-labelled hydrophilic sulfonated products in high yields. A two-step sequence including radiofluorination and coupling to lysine was then developed from a bis-sultone precursor as a model approach for the labelling of biopolymers.
authors.affiliation: LDM-TEP, CEA/DSV/I2BM/CI-NAPS UMR6232, CNRS, Université de Caen Basse-Normandie, Cyceron, Boulevard Henri Becquerel, 14074 Caen cedex, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Schmitt
authors.forename: Cédric
authors.initials: C
authors.lastname: Bouteiller
authors.forename: Louisa
authors.initials: L
authors.lastname: Barré
authors.forename: Cécile
authors.initials: C
authors.lastname: Perrio
mesh_terms: D001704:Biopolymers / Q000737:chemistry; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods; D008239:Lysine / Q000737:chemistry; D009282:Naphthalenesulfonates / Q000737:chemistry*; D049268:Positron-Emission Tomography / Q000379:methods
chemical_list: D001704:Biopolymers; D005462:Fluorine Radioisotopes; D009282:Naphthalenesulfonates; C016768:naphthosultone; D008239:Lysine