title: [Alteration of UV-sensitivity of mice peritoneal macrophage plasma membranes by calcium ions].
abstract: Effect of Ca2+ ions on UV-induced mice peritoneal macrophage plasma membrane damage has been studied. Drop of the extracellular Ca2+ concentration has been found to result in a reduced expression of this damage. On the contrary, a raised intra- and extra-cellular Ca2+ level is associated with a higher number of cells with damaged plasma membranes. These findings make it possible to suggest that this change in the plasma membrane photosensitivity might be a result of alterations in the membrane lipid matrix electrical stability owing to UV-induced lipid photo-peroxidation. This study has also shown that free radical peroxidation of membrane lipids plays a significant part in UV-induced cell damage.
authors.forename: S K
authors.initials: SK
authors.lastname: Pirutin
authors.forename: V B
authors.initials: VB
authors.lastname: Turovetskiĭ
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Kudriashov
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002462:Cell Membrane / Q000528:radiation effects*; D002478:Cells, Cultured; D004307:Dose-Response Relationship, Radiation; D007477:Ions / Q000378:metabolism; D017737:Macrophages, Peritoneal / Q000528:radiation effects*; D051379:Mice; D014466:Ultraviolet Rays
chemical_list: D007477:Ions; D002118:Calcium