title: Bactericidal activity of topical antiseptics and their gargles against Bordetella pertussis.
abstract: Bordetella pertussis is the etiological agent of whooping cough, a common cause of respiratory illness in both children and adults. In the present study, we investigated the bactericidal activity of four antiseptics-povidone-iodine (PVP-I), benzethonium chloride (BEC), chlorhexidine gluconate (CHG) and benzalkonium chloride (BAC)-against B. pertussis ATCC9797 and clinical isolates. Among the topical antiseptics, PVP-I, BEC, and BAC, PVP-I and BAC in particular, showed high bactericidal activity, whereas CHG had low activity. PVP-I gargle also showed high bactericidal activity, similar to topical PVP-I. However, BEC gargle had low bactericidal activity. Our results indicate that topical PVP-I and BAC, and PVP-I gargle would be useful as effective antiseptics against B. pertussis.
authors.affiliation: Pharmaceutical Research Center, Meiji Seika Pharma Co., Ltd., Yokohama, Japan. takahisa.suzuki@meiji.com
authors.forename: Takahisa
authors.initials: T
authors.lastname: Suzuki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kataoka
authors.forename: Takashi
authors.initials: T
authors.lastname: Ida
authors.forename: Kazunari
authors.initials: K
authors.lastname: Kamachi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Mikuniya
mesh_terms: D000287:Administration, Topical; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001548:Benzalkonium Compounds / Q000494:pharmacology; D001558:Benzethonium / Q000494:pharmacology; D001886:Bordetella pertussis / Q000187:drug effects* / Q000302:isolation & purification; D002710:Chlorhexidine / Q000031:analogs & derivatives / Q000494:pharmacology; D015169:Colony Count, Microbial; D006801:Humans; D009067:Mouthwashes / Q000494:pharmacology; D011206:Povidone-Iodine / Q000494:pharmacology; D014917:Whooping Cough / Q000382:microbiology
chemical_list: D000891:Anti-Infective Agents, Local; D001548:Benzalkonium Compounds; D009067:Mouthwashes; D001558:Benzethonium; D011206:Povidone-Iodine; C010882:chlorhexidine gluconate; D002710:Chlorhexidine