title: Prodromal dementia with lewy bodies manifesting as sertraline-induced parkinsonism: a case report.
abstract: OBJECTIVE
  To describe a patient with prodromal dementia with Lewy bodies (DLB) manifesting as sertraline-induced parkinsonism.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Tertiary referral center.
  
  
  METHODS
  A 75-year-old man who initially presented with anxiety and depression along with mild cognitive impairment, later developed drug-induced parkinsonism because of sertraline treatment, and eventually showed symptoms and signs of probable DLB.
  
  
  METHODS
  Sertraline treatment for depression.
  
  
  METHODS
  : Clinical examination, magnetic resonance imaging, neuropsychologic test, and cardiac I-metaiodobenzylguanidine scintigraphy.
  
  
  RESULTS
  His parkinsonian symptoms, which became apparent after sertraline therapy, improved markedly after the discontinuation of the drug. When he started taking sertraline, he had no dementia but had mild cognitive impairment. However, he eventually showed most of the symptoms and signs to indicate probable DLB.
  
  
  CONCLUSIONS
  To our knowledge, there has been no report of sertraline-induced or aggravated parkinsonian motor symptoms in DLB patients. Our patient had a short period with neither dementia nor parkinsonism during the early stage of his illness, and this period might have been regarded as the preclinical stage of DLB in the natural course of his illness.
authors.affiliation: Department of Neurology, Keyo Medical Foundation, Keyo Geriatric Hospital, Anyang, Republic of Korea.
authors.forename: Jin-Hyuck
authors.initials: JH
authors.lastname: Kim
authors.forename: Jaeseol
authors.initials: J
authors.lastname: Park
authors.forename: Kyung-Ho
authors.initials: KH
authors.lastname: Yu
authors.forename: Hyeo-Il
authors.initials: HI
authors.lastname: Ma
authors.forename: Byung-Chul
authors.initials: BC
authors.lastname: Lee
authors.forename: Imyel
authors.initials: I
authors.lastname: Kim
authors.forename: Yun Joong
authors.initials: YJ
authors.lastname: Kim
mesh_terms: D000368:Aged; D001007:Anxiety / Q000188:drug therapy; D060825:Cognitive Dysfunction / Q000188:drug therapy; D003704:Dementia / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis; D003863:Depression / Q000188:drug therapy; D005500:Follow-Up Studies; D006801:Humans; D016631:Lewy Bodies / Q000187:drug effects / Q000473:pathology*; D008297:Male; D009483:Neuropsychological Tests; D020734:Parkinsonian Disorders / Q000139:chemically induced* / Q000150:complications; D020280:Sertraline / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D020280:Sertraline