title: Monocytic HLA DR antigens in schizophrenic patients.
abstract: A genetic association of specific human leukocyte antigens (HLA) DR genes and schizophrenia has recently been shown. These HLA play a fundamental role in the control of immune responses. Furthermore infectious agents have been proposed to be involved in the pathogenesis of schizophrenia. In this study we investigated the rate of HLA DR positive monocytes in schizophrenic patients compared to controls with a special focus on the adaption to in vitro stimulation with toll-like receptor ligands. Patients with schizophrenia and matched controls were included. For each individual, we evaluated the rate of HLA DR positive monocytes (either incubated at 37 °C or after stimulation with lipopolysaccharide or Poly I:C). We found a significantly higher percentage of schizophrenic patients with elevated HLA DR positive cells (p=0.045) as compared to controls. The adjustment rate from baseline levels of monocytic HLA DR positive cells to stimulation with Poly I:C was significantly lower in schizophrenic patients (p=0.038). The increased monocytic HLA DR in schizophrenic patients and the maladjustment of their monocytic HLA DR levels to an infectious stimulus might be a sign for a disturbed monocytic immune balance in schizophrenic individuals.
authors.affiliation: Department of Psychiatry, Ludwig-Maximilians University Munich, 80336 Munich, Germany. Daniela.Krause@med.uni-muenchen.de
authors.forename: Daniela
authors.initials: D
authors.lastname: Krause
authors.forename: Jenny
authors.initials: J
authors.lastname: Wagner
authors.forename: Judith
authors.initials: J
authors.lastname: Matz
authors.forename: Elif
authors.initials: E
authors.lastname: Weidinger
authors.forename: Michael
authors.initials: M
authors.lastname: Obermeier
authors.forename: Michael
authors.initials: M
authors.lastname: Riedel
authors.forename: Rudolf
authors.initials: R
authors.lastname: Gruber
authors.forename: Markus
authors.initials: M
authors.lastname: Schwarz
authors.forename: Norbert
authors.initials: N
authors.lastname: Mueller
mesh_terms: D000328:Adult; D005260:Female; D005434:Flow Cytometry; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D007239:Infections / Q000276:immunology; D008297:Male; D009000:Monocytes / Q000276:immunology*; D012559:Schizophrenia / Q000276:immunology* / Q000382:microbiology; D051193:Toll-Like Receptors / Q000502:physiology
chemical_list: D006684:HLA-DR Antigens; D051193:Toll-Like Receptors