title: Enamine carboxylates as stereodetermining intermediates in prolinate catalysis.
abstract: Experimental and computational studies probing the nature of intermediates in the α-amination of aldehydes catalyzed by prolinate salts support an enamine carboxylate intermediate in the stereodetermining step.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA.
authors.forename: Jason E
authors.initials: JE
authors.lastname: Hein
authors.forename: Jordi
authors.initials: J
authors.lastname: Burés
authors.forename: Yu-hong
authors.initials: YH
authors.lastname: Lam
authors.forename: Matthew
authors.initials: M
authors.lastname: Hughes
authors.forename: K N
authors.initials: KN
authors.lastname: Houk
authors.forename: Alan
authors.initials: A
authors.lastname: Armstrong
authors.forename: Donna G
authors.initials: DG
authors.lastname: Blackmond
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000586:Amination; D002264:Carboxylic Acids / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D023303:Oxazolidinones / Q000737:chemistry*; D011392:Proline / Q000031:analogs & derivatives* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D002264:Carboxylic Acids; D023303:Oxazolidinones; D011392:Proline