title: Evaluation of bee venom and hyaluronic acid in the intra-articular treatment of osteoarthritis in an experimental rabbit model.
abstract: The aim of this study was to investigate bee venom and hyaluronic acid in the intra-articular treatment of osteoarthritis in an experimental rabbit model. Forty-five rabbits were used and they were randomly divided into three groups (BVI, BVII, and HA) and each group was divided to two subgroups to evaluate the radiologic, magnetic resonance imaging, histopathologic, and biochemical evaluation in post treatment second week (a) and twelfth week (b). Radiologically, a significant difference was observed in the HA group (P<0.05). The MRI evaluation of at any time in group BVI(b) was found to be different. No significant differences were seen between the groups, biochemically. Histopathologically, cellularity, and orthochromasia was evident with Safranin-O in the BVI(b) and BVII(a); adhesions were seen in the BVII(a) group and clustering of chondrocyte in the HA(b) group were found to be different. Consequently, intra-articular application of HA and BV for experimental model of osteoarthritis has no significant influence upon recovery after therapy.
authors.affiliation: Department of Surgery, Faculty of Veterinary Medicine, Ondokuz Mayis University, Kurupelit, 55139 Samsun, Turkey. onisbet@omu.edu.tr
authors.forename: H
authors.initials: H
authors.lastname: Ozlem Nisbet
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ozak
authors.forename: Cenk
authors.initials: C
authors.lastname: Yardimci
authors.forename: Cevat
authors.initials: C
authors.lastname: Nisbet
authors.forename: Murat
authors.initials: M
authors.lastname: Yarim
authors.forename: I Koray
authors.initials: IK
authors.lastname: Bayrak
authors.forename: Y Sinan
authors.initials: YS
authors.lastname: Sirin
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001514:Bee Venoms / Q000008:administration & dosage / Q000627:therapeutic use*; D001798:Blood Proteins / Q000032:analysis; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D007270:Injections, Intra-Articular / Q000662:veterinary; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008279:Magnetic Resonance Imaging; D008297:Male; D010003:Osteoarthritis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000208:ethnology / Q000473:pathology; D011817:Rabbits; D011859:Radiography
chemical_list: D001514:Bee Venoms; D001798:Blood Proteins; D006820:Hyaluronic Acid; D003404:Creatinine; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase