title: Primary cilia and coordination of receptor tyrosine kinase (RTK) signalling.
abstract: Primary cilia are microtubule-based sensory organelles that coordinate signalling pathways in cell-cycle control, migration, differentiation and other cellular processes critical during development and for tissue homeostasis. Accordingly, defects in assembly or function of primary cilia lead to a plethora of developmental disorders and pathological conditions now known as ciliopathies. In this review, we summarize the current status of the role of primary cilia in coordinating receptor tyrosine kinase (RTK) signalling pathways. Further, we present potential mechanisms of signalling crosstalk and networking in the primary cilium and discuss how defects in ciliary RTK signalling are linked to human diseases and disorders.
authors.affiliation: Department of Biology, University of Copenhagen, Copenhagen, Denmark. stchristensen@bio.ku.dk
authors.forename: Søren T
authors.initials: ST
authors.lastname: Christensen
authors.forename: Christian A
authors.initials: CA
authors.lastname: Clement
authors.forename: Peter
authors.initials: P
authors.lastname: Satir
authors.forename: Lotte B
authors.initials: LB
authors.lastname: Pedersen
mesh_terms: D002450:Cell Communication / Q000502:physiology; D002453:Cell Cycle / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D002923:Cilia / Q000737:chemistry / Q000502:physiology*; D066246:ErbB Receptors / Q000502:physiology; D006801:Humans; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology*; D017526:Receptor, IGF Type 1 / Q000502:physiology; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000502:physiology; D017468:Receptors, Fibroblast Growth Factor / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D017468:Receptors, Fibroblast Growth Factor; D066246:ErbB Receptors; D020794:Receptor Protein-Tyrosine Kinases; D017526:Receptor, IGF Type 1; D020796:Receptor, Platelet-Derived Growth Factor alpha