title: Invasive polyarticular septic arthritis caused by nontypeable haemophilus influenzae in a young adult: a case report and literature review.
abstract: Nontypeable Haemophilus influenzae is a rare cause of septic arthritis in adults and has been reported to be associated with underlying medical conditions. We present a case of nontypeable H. influenzae-infected severe invasive polyarticular septic arthritis in a young adult without any underlying predisposing medical conditions. Diagnosis was made from both positive blood culture and joint aspiration culture. The patient was successfully treated with employment of aggressive surgical debridement of multiple affected septic joints as well as prolonged antibiotic treatment. Further laboratory testing did not reveal significant underlying medical conditions including negative HIV, normal levels of complement and IgG subclasses, and normal-appearing spleen on computed tomography. This case illustrates that nontypeable H. influenzae can cause serious invasive septic arthritis infection in both patients with and without predisposing underlying medical conditions and that prompt diagnosis with aggressive treatment of combined surgical and medical treatment can result in optimal recovery.
authors.affiliation: Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
authors.forename: Jong Hun
authors.initials: JH
authors.lastname: Kim
authors.forename: Carlene A
authors.initials: CA
authors.lastname: Muto
authors.forename: A William
authors.initials: AW
authors.lastname: Pasculle
authors.forename: Emanuel N
authors.initials: EN
authors.lastname: Vergis
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D018771:Arthralgia / Q000209:etiology; D001170:Arthritis, Infectious / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D015373:Bacterial Typing Techniques; D003646:Debridement; D005334:Fever / Q000209:etiology; D006192:Haemophilus Infections / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D006193:Haemophilus influenzae / Q000145:classification / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D013582:Synovial Fluid / Q000382:microbiology; D007507:Therapeutic Irrigation
chemical_list: D000900:Anti-Bacterial Agents