title: Ictal haemodynamic changes in a patient affected by "subtle" Epilepsia Partialis Continua.
abstract: We report on a 64 year-old woman presenting with Epilepsia Partialis Continua (EPC) affecting the left hand since the age of 24 without neurological deficit. Structural MRI showed a region of focal cortical dysplasia (FCD) over the right central gyrus and lesions in the mesial frontal and occipital cortex secondary to perinatal hypoxic injury. Ictal spike haemodynamic mapping using simultaneous EEG-fMRI revealed significant BOLD signal changes prominent in the region of FCD (larger cluster), occipital cortex (global statistical maximum), prefrontal cortex and cerebellum. The cluster over FCD was in good agreement with the result of EEG source analysis. Our findings provide an interesting illustration of the ability of EEG-fMRI to reveal epileptogenic networks confirming the intrinsic epileptogenic properties of dysplastic neurons.
authors.affiliation: Department of Neurological Sciences, University of Rome La Sapienza, Viale dell'Universita' 30, 00185, Rome, Italy. AnnaVaudano@gmail.com
authors.forename: Anna Elisabetta
authors.initials: AE
authors.lastname: Vaudano
authors.forename: Carlo
authors.initials: C
authors.lastname: Di Bonaventura
authors.forename: Marco
authors.initials: M
authors.lastname: Carni
authors.forename: Roman
authors.initials: R
authors.lastname: Rodionov
authors.forename: Leonardo
authors.initials: L
authors.lastname: Lapenta
authors.forename: Sara
authors.initials: S
authors.lastname: Casciato
authors.forename: Jinane
authors.initials: J
authors.lastname: Fattouch
authors.forename: Gabriella
authors.initials: G
authors.lastname: Egeo
authors.forename: Patrizia
authors.initials: P
authors.lastname: Pantano
authors.forename: Valter
authors.initials: V
authors.lastname: Nucciarelli
authors.forename: Bruno
authors.initials: B
authors.lastname: Maraviglia
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Prencipe
authors.forename: Louis
authors.initials: L
authors.lastname: Lemieux
authors.forename: Anna Teresa
authors.initials: AT
authors.lastname: Giallonardo
mesh_terms: D001921:Brain / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology*; D004569:Electroencephalography; D017036:Epilepsia Partialis Continua / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D054220:Malformations of Cortical Development / Q000150:complications* / Q000473:pathology / Q000503:physiopathology*; D008875:Middle Aged; D012815:Signal Processing, Computer-Assisted