title: Catalytic asymmetric Pictet-Spengler-type reaction for the synthesis of optically active indolo[3,4-cd][1]benzazepines.
abstract: A new strategy has been introduced to develop a catalytic asymmetric Pictet-Spengler-type reaction by replacing the aldehyde with an imine. A range of 4-(2-aminoaryl)indoles smoothly undergo the chiral phosphoric acid catalyzed asymmetric Pictet-Spengler-type reaction with imines at room temperature to give structurally diverse indolo[3,4-cd][1]benzazepines in good to excellent yields and ee.
authors.affiliation: Joint Laboratory of Green Synthetic Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China.
authors.forename: Dao-Juan
authors.initials: DJ
authors.lastname: Cheng
authors.forename: Hai-Bian
authors.initials: HB
authors.lastname: Wu
authors.forename: Shi-Kai
authors.initials: SK
authors.lastname: Tian