title: Choosing optimal wavelength for photodynamic therapy of port wine stains by mathematic simulation.
abstract: Many laser wavelengths have been used in photodynamic therapy (PDT) for port wine stains (PWS). However, how these wavelengths result in different PDT outcomes has not been clearly illuminated. This study is designed to analyze which wavelengths would be the most advantageous for use in PDT for PWS. The singlet oxygen yield in PDT-treated PWS skin under different wavelengths at the same photosensitizer dosage was simulated and the following three situations were simulated and compared: 1. PDT efficiency of 488, 532, 510, 578, and 630 nm laser irradiation at clinical dosage (100 mW∕cm(2), 40 min); 2. PDT efficiency of different wavelength for PWS with hyperpigmentation after previous PDT; 3. PDT efficiency of different wavelengths for PWS, in which only deeply located ectatic vessels remained. The results showed that singlet oxygen yield is the highest at 510 nm, it is similar at 532 nm and 488 nm, and very low at 578 nm and 630 nm. This result is identical to the state in clinic. According to this theoretical study, the optimal wavelength for PDT in the treatment of PWS should near the absorption peaks of photosensitizer and where absorption from native chromophores (haemoglobin and melanin) is diminished.
authors.affiliation: Chinese People's Liberation Army General Hospital, Department of Laser Medicine, Beijing 100853, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Gu
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Zuo
authors.forename: Naiyan
authors.initials: N
authors.lastname: Huang
mesh_terms: D000042:Absorption; D000465:Algorithms; D003198:Computer Simulation; D004058:Diffusion; D006415:Hematoporphyrins / Q000737:chemistry / Q000627:therapeutic use; D006454:Hemoglobins / Q000737:chemistry; D006801:Humans; D017495:Hyperpigmentation / Q000188:drug therapy / Q000503:physiopathology; D053685:Laser Therapy / Q000379:methods*; D008543:Melanins / Q000737:chemistry; D008954:Models, Biological; D009010:Monte Carlo Method; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000737:chemistry / Q000627:therapeutic use; D019339:Port-Wine Stain / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery; D026082:Singlet Oxygen / Q000737:chemistry
chemical_list: D006415:Hematoporphyrins; D006454:Hemoglobins; D008543:Melanins; D017319:Photosensitizing Agents; C494379:hematoporphyrin monomethyl ether; D026082:Singlet Oxygen