title: The first reported case of canine subcutaneous Cryptococcus flavescens infection.
abstract: This report describes the first documented case of subcutaneous infection due to Cryptococcus flavescens in a dog. The chief symptoms of the patient dog were abscessed lesions on the dorsal muzzle, right eyelid, and lower jaw. Biopsy specimens from the lesions on the dorsal muzzle and lower jaw showed pyogranulomatous inflammation with numerous yeast cells. The patient dog was diagnosed with a subcutaneous fungal infection and orally received 5 mg/kg itraconazole once a day for 2 months, the abscesses disappeared. After 1 month at the end of treatment, the skin lesions did not redevelop. Isolates from the biopsy specimens were identified as C. flavescens by molecular analysis as well as morphologic and biochemical examination, indicating that C. flavescens is a potential canine pathogen.
authors.affiliation: Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa, Japan. kano@brs.nihon-u.ac.jp
authors.forename: Rui
authors.initials: R
authors.lastname: Kano
authors.forename: Rinei
authors.initials: R
authors.lastname: Ishida
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Nakane
authors.forename: Maiko
authors.initials: M
authors.lastname: Sekiguchi
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Hasegawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kamata
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D003453:Cryptococcosis / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D003454:Cryptococcus / Q000235:genetics / Q000302:isolation & purification*; D003881:Dermatomycoses / Q000188:drug therapy / Q000382:microbiology*; D004283:Dog Diseases / Q000188:drug therapy / Q000382:microbiology*; D004285:Dogs; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole