title: Administering human adipose-derived mesenchymal stem cells to prevent and treat experimental arthritis.
abstract: Rheumatoid arthritis is a chronic autoimmune disease and affecting approximately 1% of the population. Human adipose-derived mesenchymal stem cells (hASCs) were recently found to suppress effector T cell and inflammatory responses and, thus, to have beneficial effects in various autoimmune diseases. In this study, we examined whether hASCs could play a protective and/or therapeutic role in collagen-induced arthritis (CIA). We showed that hASCs both prevented and treated CIA by significantly reducing the incidence and severity of experimental arthritis. We further demonstrated that treatment with hASCs inhibited the production of various inflammatory mediators, decreased antigen-specific Th1/Th17 cell expansion, and induced the production of anti-inflammatory cytokine interleukin-10. Moreover, hASCs could induce the generation of antigen-specific Treg cells with the capacity to suppress collagen-specific T cell responses.
authors.affiliation: Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhou
authors.forename: Jingdong
authors.initials: J
authors.lastname: Yuan
authors.forename: Yixuan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Maher
authors.initials: M
authors.lastname: Ghawji
authors.forename: Yun-Ping
authors.initials: YP
authors.lastname: Deng
authors.forename: Austin J
authors.initials: AJ
authors.lastname: Lee
authors.forename: Albert J
authors.initials: AJ
authors.lastname: Lee
authors.forename: Usha
authors.initials: U
authors.lastname: Nair
authors.forename: Andrew H
authors.initials: AH
authors.lastname: Kang
authors.forename: David D
authors.initials: DD
authors.lastname: Brand
authors.forename: Tai June
authors.initials: TJ
authors.lastname: Yoo
mesh_terms: D000273:Adipose Tissue / Q000276:immunology*; D000818:Animals; D001169:Arthritis, Experimental / Q000276:immunology / Q000628:therapy*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002478:Cells, Cultured; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000276:immunology / Q000378:metabolism; D016753:Interleukin-10 / Q000096:biosynthesis / Q000276:immunology; D045164:Mesenchymal Stem Cell Transplantation; D051379:Mice; D008811:Mice, Inbred DBA; D012720:Severity of Illness Index; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology
chemical_list: C556062:IL10 protein, mouse; D018836:Inflammation Mediators; D016753:Interleukin-10