title: Association between plasma levels of pigment epithelium-derived factor and renal dysfunction in patients with coronary artery disease.
abstract: BACKGROUND
  Although plasma pigment epithelium-derived factor (PEDF) levels have been shown to be significantly correlated with the levels of creatinine (Cr) in type 2 diabetes, little is known about the association between PEDF levels and renal dysfunction in patients with coronary artery disease (CAD).
  
  
  METHODS
  We enrolled 134 consecutive patients with diagnosed CAD and measured plasma levels of PEDF, serum Cr, uric acid (UA) and high-sensitive C-reactive protein (hsCRP).
  
  
  RESULTS
  Plasma PEDF levels were positively correlated with serum Cr (p 〈 0.0001) and UA (p 〈 0.0001) and negatively correlated with the estimated glomerular filtration rate (eGFR) (p 〈 0.0001), whereas there was no association between plasma PEDF and age or hsCRP. When the subjects were divided into five groups (0-4) according to the number of metabolic factors (obesity, diabetes, hypertension and dyslipidemia), PEDF levels in patients with four factors were significantly higher than those in patients without factors. Next, we divided the patients into quartiles according to their plasma PEDF levels (〈 9.9 μg/mL, 9.9-12.8, 12.9- -15.7, 〉 15.7). The eGFR in the first group was significantly higher than those in the third and fourth groups. Multivariate logistic analysis indicated that eGFR (p 〈 0.0001) and age (p = 0.030) were significant independent variables that correlated with the quartile classification according to PEDF levels.
  
  
  CONCLUSIONS
  This study revealed that PEDF may play a role in renal dysfunction in CAD patients.
authors.affiliation: Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.
authors.forename: Tadaaki
authors.initials: T
authors.lastname: Arimura
authors.forename: Shin-ichiro
authors.initials: S
authors.lastname: Miura
authors.forename: Makoto
authors.initials: M
authors.lastname: Sugihara
authors.forename: Atsushi
authors.initials: A
authors.lastname: Iwata
authors.forename: Sho-ichi
authors.initials: S
authors.lastname: Yamagishi
authors.forename: Keijiro
authors.initials: K
authors.lastname: Saku
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D016009:Chi-Square Distribution; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D005136:Eye Proteins / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007564:Japan; D007668:Kidney / Q000503:physiopathology*; D007674:Kidney Diseases / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood*; D016017:Odds Ratio; D012189:Retrospective Studies; D015843:Serpins / Q000097:blood*; D014527:Uric Acid / Q000097:blood; D000099174:Pigment Epithelium-Derived Factor
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D003404:Creatinine; D005136:Eye Proteins; D009414:Nerve Growth Factors; D015843:Serpins; D014527:Uric Acid; D000099174:Pigment Epithelium-Derived Factor