title: Chikungunya virus: evolution and genetic determinants of emergence.
abstract: Chikungunya virus (CHIKV) causes a severe and often persistent arthralgic disease that is occasionally fatal. A mosquito-borne virus, CHIKV exists in enzootic, non-human primate cycles in Africa, but occasionally emerges into urban, human cycles to cause major epidemics. Between 1920 and 1950, and again in 2005, CHIKV emerged into India and Southeast Asia, where major urban epidemics ensued. Unlike the early introduction, the 2005 emergence was accompanied by an adaptive mutation that allowed CHIKV to exploit a new epidemic vector, Aedes albopictus, via an A226V substitution in the E1 envelope glycoprotein. However, recent reverse genetic studies indicate that lineage-specific epistatic restrictions can prevent this from exerting its phenotype on mosquito infectivity. Thus, the A. albopictus-adaptive A226V substitution that is facilitating the dramatic geographic spread CHIKV epidemics, was prevented for decades or longer from being selected in most African enzootic strains as well as in the older endemic Asian lineage.
authors.affiliation: Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas USA.
authors.forename: Konstantin A
authors.initials: KA
authors.lastname: Tsetsarkin
authors.forename: Rubing
authors.initials: R
authors.lastname: Chen
authors.forename: Michael B
authors.initials: MB
authors.lastname: Sherman
authors.forename: Scott C
authors.initials: SC
authors.lastname: Weaver
mesh_terms: D000330:Aedes / Q000821:virology; D018354:Alphavirus Infections / Q000453:epidemiology / Q000635:transmission / Q000821:virology*; D000818:Animals; D002646:Chikungunya virus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D019143:Evolution, Molecular; D006801:Humans; D007303:Insect Vectors / Q000821:virology; D010802:Phylogeny