title: Models of renal insufficiency: the anti-thy-1.1 model of acute proliferative glomerulonephritis.
abstract: This unit describes the rat anti-Thy-1.1 model of acute proliferative glomerulonephritis for the study of chronic renal insufficiency. A procedure is detailed for the induction of glomerulonephritis in rats as well as measurement of daily urinary excretion of protein, which is a convenient, primary screening tool. The unit also provides methods for assessment of glomerular filtration rate and effective renal plasma flow in anesthetized rats with anti-Thy-1.1-induced renal insufficiency.
authors.affiliation: Abbott Laboratories, Abbott Park, Illinois, USA.
authors.forename: G A
authors.initials: GA
authors.lastname: Reinhart
authors.forename: B F
authors.initials: BF
authors.lastname: Cox
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005919:Glomerular Filtration Rate / Q000276:immunology; D015432:Glomerulonephritis, Membranoproliferative / Q000139:chemically induced / Q000276:immunology*; D007518:Isoantibodies / Q000276:immunology* / Q000633:toxicity; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D051437:Renal Insufficiency / Q000139:chemically induced / Q000276:immunology*
chemical_list: D007518:Isoantibodies; C035678:anti-Thy antibody