title: A WNTer revisit: new faces of β-catenin and TCFs in pluripotency.
abstract: New evidence has revealed interesting aspects of how the Wnt-β-catenin pathway controls self-renewal and lineage differentiation of pluripotent embryonic stem cells. Although Wnt-β-catenin signaling is dispensable for the self-renewal of naive mouse embryonic stem cells, it facilitates their expansion and resistance to differentiation through an unconventional dual mechanism involving the transcriptional repressor T cell factor (TCF) 3 and the transcriptional activator TCF1.
authors.affiliation: Department of Biological Chemistry, School of Medicine, D250 Med Sci I, University of California, Irvine, CA 92697-1700, USA.
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Watanabe
authors.forename: Xing
authors.initials: X
authors.lastname: Dai
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism; D053595:Embryonic Stem Cells / Q000166:cytology / Q000502:physiology*; D051538:Hepatocyte Nuclear Factor 1-alpha / Q000235:genetics / Q000378:metabolism; D051379:Mice; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000502:physiology*; D051153:Wnt Proteins / Q000235:genetics / Q000378:metabolism*; D060449:Wnt Signaling Pathway / Q000502:physiology*; D051176:beta Catenin / Q000235:genetics
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D051538:Hepatocyte Nuclear Factor 1-alpha; D051153:Wnt Proteins; D051176:beta Catenin; C496488:Hnf1a protein, mouse; C075668:Tcf3 protein, mouse