title: [Age-related characteristics of melanocytes in the hair follicles of the temporal region skin in men].
abstract: Using morphometric and immunocytochemical methods, the distribution of melanin-containing cells in the hair follicles was studied using the autopsy samples of the skin obtained from the temporal region of scalp of 74 male individuals of different age (10-79 years). In all age groups, the melanocytes were identified only in the epithelial hair matrix - both in sections stained with hematoxylin-eosin and in sections treated with the monoclonal antibodies against tyrosinase. The examination of unstained sections demonstrated that after 15 years the reduction of a total area occupied by melanin granules in the cytoplasm of melanocytes and keratinocytes took place. After 26 years the irregular but stable decrease was found in the number of pigment-forming cells. The number of melanocytes identified using the monoclonal antibodies against tyrosinase, was greater then the number of pigment cell detected by routine methods.
authors.forename: V I
authors.initials: VI
authors.lastname: Nozdrin
authors.forename: A G
authors.initials: AG
authors.lastname: Alekseev
authors.forename: T A
authors.initials: TA
authors.lastname: Belousova
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism / Q000473:pathology; D002452:Cell Count; D002648:Child; D018859:Hair Follicle / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008543:Melanins / Q000378:metabolism*; D008544:Melanocytes / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D055815:Young Adult
chemical_list: D008543:Melanins