title: Smoking related cancers and loci at chromosomes 15q25, 5p15, 6p22.1 and 6p21.33 in the Polish population.
abstract: Genetic factors associated with the risk of smoking related cancers have until recently remained elusive. Since the publication of a genome-wide association study (GWAS) on lung cancer new genetic loci have been identified that appear to be associated with disease risk. In this replication study we genotyped 14 single nucleotide polymorphisms (SNPs) located at the 5p12.3-p15.33, 6p21.3-p22.1, 6q23-q27 and 15q25.1 loci in 874 lung, 450 bladder, 418 laryngeal cancer cases and cancer-free controls, matched by year of birth and sex to the cases. Our results revealed that loci in the chromosome region 15q25.1 (rs16969968[A], rs8034191[G]) and 5p15 (rs402710[T]) are associated with lung cancer risk in the Polish population (smoking status adjusted OR = 1.45, 1.35, 0.77; p ≤ 0.0001, 0.0005, 0.002; 95%CI 1.23-1.72, 1.14-1.59, 0.66-0.91 respectively). None of the other regions analyzed herein were implicated in the risk of lung, bladder or laryngeal cancer. This study supports previous findings on lung cancer but fails to show association of SNPs located in 15q25.1 and 5p15 region with other smoking related cancers like bladder and laryngeal cancer.
authors.affiliation: Department of Otolaryngology and Laryngological Oncology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Jaworowska
authors.forename: Joanna
authors.initials: J
authors.lastname: Trubicka
authors.forename: Marcin R
authors.initials: MR
authors.lastname: Lener
authors.forename: Bartłomiej
authors.initials: B
authors.lastname: Masojć
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Złowocka-Perłowska
authors.forename: James D
authors.initials: JD
authors.lastname: McKay
authors.forename: Hélène
authors.initials: H
authors.lastname: Renard
authors.forename: Dorota
authors.initials: D
authors.lastname: Oszutowska
authors.forename: Dominika
authors.initials: D
authors.lastname: Wokołorczyk
authors.forename: Jakub
authors.initials: J
authors.lastname: Lubiński
authors.forename: Tomasz
authors.initials: T
authors.lastname: Grodzki
authors.forename: Piotr
authors.initials: P
authors.lastname: Serwatowski
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Nej-Wołosiak
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Tołoczko-Grabarek
authors.forename: Andrzej
authors.initials: A
authors.lastname: Sikorski
authors.forename: Marcin
authors.initials: M
authors.lastname: Słojewski
authors.forename: Anna
authors.initials: A
authors.lastname: Jakubowska
authors.forename: Cezary
authors.initials: C
authors.lastname: Cybulski
authors.forename: Jan
authors.initials: J
authors.lastname: Lubiński
authors.forename: Rodney J
authors.initials: RJ
authors.lastname: Scott
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002884:Chromosomes, Human, Pair 15; D002896:Chromosomes, Human, Pair 6; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D007822:Laryngeal Neoplasms / Q000209:etiology / Q000235:genetics*; D008175:Lung Neoplasms / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011044:Poland; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D012907:Smoking / Q000009:adverse effects*; D001749:Urinary Bladder Neoplasms / Q000209:etiology / Q000235:genetics*