title: Halioxepine, a new meroditerpene from an Indonesian sponge Haliclona sp.
abstract: Chemical investigations on a sponge Haliclona sp. found a meroditerpene 1 having a new carbon skeleton. By analyzing spectroscopic data, the structure was elucidated to comprise a substituted hydroquinone, a tetrahydrooxepine, and a cyclohexene, and these components were united with C1 and C2 units. Compound 1 showed moderate cytotoxicity against NBT-T2 cells with IC50 4.8 µg/ml and also antioxidant activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) with IC50 3.2 µg/ml.
authors.affiliation: Department of Marine Sciences, Faculty of Fisheries and Marine Sciences, University of Diponegoro, Semarang, Central Java, Indonesia.
authors.forename: Agus
authors.initials: A
authors.lastname: Trianto
authors.forename: Idam
authors.initials: I
authors.lastname: Hermawan
authors.forename: Nicole Joy
authors.initials: NJ
authors.lastname: de Voogd
authors.forename: Junichi
authors.initials: J
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000032:analysis / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001685:Biological Factors; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000032:analysis / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004354:Drug Screening Assays, Antitumor; D047129:Haliclona / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D001685:Biological Factors; D004224:Diterpenes; C573106:halioxepine