title: A study on the influence of ethanol over the primary cultured rat cortical neurons by using the scanning electron microscopy.
abstract: As an inhibitor and toxic factor of central nervous system, ethanol inhibits the action of the neurons and causes various kinds of neuronal damage. However, the precise mechanisms that ethanol-induced neuronal damage in the central nervous system remain unclear. In spite of thousands of published studies, little information is available on the neurons' morphological alteration in the central nervous system. In this study, we investigated the morphological alterations of the primary cultured rat cortical neurons after they were treated by different concentrations of ethanol using the scanning electron microscopy. Our results showed that the moderate or high concentration of ethanol could lead to morphological changes of these cultured rat cortical neurons, and they were closely associated with the duration of time. Our study will provide a new base for further studies on the effects of ethanol in the central nervous system.
authors.affiliation: Department of Forensic Medicine, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China.
authors.forename: Hanmei
authors.initials: H
authors.lastname: Qiu
authors.forename: Hongtao
authors.initials: H
authors.lastname: Yan
authors.forename: Jianpin
authors.initials: J
authors.lastname: Tang
authors.forename: Zhaoshu
authors.initials: Z
authors.lastname: Zeng
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D000431:Ethanol / Q000633:toxicity*; D008855:Microscopy, Electron, Scanning; D009474:Neurons / Q000187:drug effects* / Q000648:ultrastructure*; D051381:Rats; D013997:Time Factors
chemical_list: D000431:Ethanol