title: Decreased concentrations of soluble interleukin-1 receptor accessory protein levels in the peritoneal fluid of women with endometriosis.
abstract: Interleukin 1 (IL1) may play an important role in endometriosis-associated pelvic inflammation, and natural specific inhibitors, including soluble IL1 receptor accessory protein (sIL1RAcP) and soluble IL1 receptor type 2 (sIL1R2), are critical for counterbalancing the pleiotropic effects of IL1. The objective of this study was to evaluate the levels of sIL1RAcP, together with those of sIL1R2 and IL1β, in the peritoneal fluid of women with and without endometriosis. Peritoneal fluid samples were obtained at laparoscopy and assessed by ELISA. sIL1RAcP concentrations were reduced in endometriosis stages I-II and III-IV. sIL1R2 concentrations were decreased, and those of IL1β were significantly increased in endometriosis stages I-II. sIL1RAcP and sIL1R2 concentrations were significantly decreased in the secretory phase of the menstrual cycle, and IL1β concentrations were elevated in the proliferative and the secretory phases. sIL1RAcP and sIL1R2 concentrations were reduced in women with endometriosis who were infertile, fertile, suffering from pelvic pain or pain-free. However, IL1β concentrations were significantly reduced in women with endometriosis who were infertile or had pelvic pain. These changes may exacerbate the local peritoneal inflammatory reaction observed in women with endometriosis and contribute to endometriosis pathophysiology and the major symptoms of this disease.
authors.affiliation: Endocrinologie de la Reproduction, Centre de Recherche, Hôpital Saint-François d'Assise, Centre Hospitalier Universitaire de Québec, Québec, Canada.
authors.forename: Nadège
authors.initials: N
authors.lastname: Michaud
authors.forename: Mahéra
authors.initials: M
authors.lastname: Al-Akoum
authors.forename: Geneviève
authors.initials: G
authors.lastname: Gagnon
authors.forename: Karine
authors.initials: K
authors.lastname: Girard
authors.forename: Pierre
authors.initials: P
authors.lastname: Blanchet
authors.forename: Julie Anne
authors.initials: JA
authors.lastname: Rousseau
authors.forename: Ali
authors.initials: A
authors.lastname: Akoum
mesh_terms: D000328:Adult; D001202:Ascitic Fluid / Q000378:metabolism*; D018450:Disease Progression; D004715:Endometriosis / Q000276:immunology* / Q000503:physiopathology; D005260:Female; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D007246:Infertility; D007249:Inflammation; D053577:Interleukin-1 Receptor Accessory Protein / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D053583:Interleukin-1beta / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D008597:Menstrual Cycle; D017699:Pelvic Pain; D053574:Receptors, Interleukin-1 Type II / Q000235:genetics / Q000276:immunology / Q000378:metabolism*
chemical_list: C508592:IL1R2 protein, human; D053577:Interleukin-1 Receptor Accessory Protein; D053583:Interleukin-1beta; D053574:Receptors, Interleukin-1 Type II