title: Mobile DNA transposition in somatic cells.
abstract: It had been long assumed that almost all insertions of mobile DNA elements occurred during germ-cell development rather than in somatic-cell development, but solid evidence for transposition in somatic cells is now accumulating. To add to this evidence, a recent paper in Mobile DNA reports the somatic transposition of a site-specific retrotransposon, R2, into its insertion site in 28S ribosomal DNA in Drosophila embryos.
authors.affiliation: Institute for Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. kazazian@jhmi.edu
authors.forename: Haig H
authors.initials: HH
authors.lastname: Kazazian
mesh_terms: D000818:Animals; D006801:Humans; D002477:Cells / Q000378:metabolism; D004251:DNA Transposable Elements / Q000235:genetics; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics; D016254:Mutagenesis, Insertional / Q000235:genetics; D018626:Retroelements / Q000235:genetics
chemical_list: D004251:DNA Transposable Elements; D018626:Retroelements