title: Comparison of behavioral effects of morphine and fentanyl in dogs and cats.
abstract: Behavioral effects induced by intravenous administration of morphine at 0.3, 0.6, 1.2, and 2.4 µg/kg and fentanyl at 5, 10, 20, and 40 µg/kg were evaluated in dogs and cats. In dogs, fentanyl and morphine depressed activity and level of consciousness in a dose- dependant manner. In cats, higher doses of fentanyl stimulated activity temporarily, but excitement, so-called "opioid mania," was not observed. Morphine induced distinctive behavioral changes characterized by sitting with fixed staring, and "opioid mania" was not observed in cats.
authors.affiliation: Laboratory of Veterinary Emergency Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Kamata
authors.forename: Shotaro
authors.initials: S
authors.lastname: Nagahama
authors.forename: Kei
authors.initials: K
authors.lastname: Kakishima
authors.forename: Nobuo
authors.initials: N
authors.lastname: Sasaki
authors.forename: Ryohei
authors.initials: R
authors.lastname: Nishimura
mesh_terms: D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002415:Cats / Q000502:physiology / Q000523:psychology*; D004285:Dogs / Q000502:physiology / Q000523:psychology*; D005283:Fentanyl / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D009020:Morphine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D011187:Posture; D011897:Random Allocation; D056152:Respiratory Rate / Q000187:drug effects
chemical_list: D000701:Analgesics, Opioid; D009020:Morphine; D005283:Fentanyl