title: Cognitive training changes hippocampal function in mild cognitive impairment: a pilot study.
abstract: A randomized pilot experiment examined the neural substrates of response to cognitive training in participants with mild cognitive impairment (MCI). Participants performed exercises previously demonstrated to improve verbal memory and an active control group performed other computer activities. An auditory-verbal fMRI task was conducted before and after the two-month training program. Verbal memory scores improved significantly and left hippocampal activation increased significantly in the experimental group (gains in 5 of 6 participants) relative to the control group (reductions in all 6 participants). Results suggest that the hippocampus in MCI may retain sufficient neuroplasticity to benefit from cognitive training.
authors.affiliation: Department of Psychiatry, Stanford University, Stanford, CA, USA. rosena@psych.stanford.edu
authors.forename: Allyson C
authors.initials: AC
authors.lastname: Rosen
authors.forename: Lisa
authors.initials: L
authors.lastname: Sugiura
authors.forename: Joel H
authors.initials: JH
authors.lastname: Kramer
authors.forename: Susan
authors.initials: S
authors.lastname: Whitfield-Gabrieli
authors.forename: John D
authors.initials: JD
authors.lastname: Gabrieli
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001931:Brain Mapping; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D060825:Cognitive Dysfunction / Q000473:pathology* / Q000534:rehabilitation*; D005260:Female; D005500:Follow-Up Studies; D006624:Hippocampus / Q000098:blood supply / Q000503:physiopathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D010865:Pilot Projects; D016896:Treatment Outcome
chemical_list: D010100:Oxygen