title: Antimalarial activity of three Pakistani medicinal plants.
abstract: This study was conducted to determine the in vitro anti-malarial activity of three medicinal plants, Picrorhiza kurroa, Caesalpinia bonducella and Artemisia absinthium of Pakistan. Different extracts of various parts of these plants were prepared by maceration and percolation, and were evaluated for their antimalarial activity. Aqueous, cold alcoholic and hot alcoholic extracts of Picrorhiza kurroa showed 34%, 100% and 90% inhibition in growth of Plasmodium falciparum, respectively, at 2.00 mg/ml. While aqueous, cold alcoholic and hot alcoholic extracts of Caesalpinia bonducella showed 65%, 56% and 76% inhibition in growth of Plasmodium falciparum, respectively at same concentrations. In the case of Artemisia absinthium, aqueous, cold alcoholic and hot alcoholic extract of Artemisia absinthium showed 35%, 55% and 21% inhibition in growth of Plasmodium falciparum, respectively at 2.00 mg/ml. In our study, extracts of Picrorhiza kurroa were found good for traditional therapy with highly significant results.
authors.affiliation: Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan.
authors.forename: Saba
authors.initials: S
authors.lastname: Irshad
authors.forename: Abdul
authors.initials: A
authors.lastname: Mannan
authors.forename: Bushra
authors.initials: B
authors.lastname: Mirza
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D031171:Artemisia absinthium / Q000737:chemistry; D029911:Caesalpinia / Q000737:chemistry; D049109:Cell Proliferation / Q000187:drug effects; D000431:Ethanol / Q000737:chemistry; D010154:Pakistan; D010271:Parasites / Q000187:drug effects; D032261:Picrorhiza / Q000737:chemistry; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018514:Plant Structures / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D014867:Water / Q000737:chemistry
chemical_list: D000962:Antimalarials; D010936:Plant Extracts; D014867:Water; D000431:Ethanol