title: Mono- and dinuclear Ru(II) complexes of 1,4-bis(3-(2-pyridyl)pyrazol-1-ylmethyl)benzene): synthesis, structure, photophysical properties and electrochemiluminescent determination of diuretic furosemide.
abstract: Mononuclear ruthenium complex 1 and dinuclear complex 2 were synthesized by reaction of the appropriate bidentate pyrazolyl-pyridyl-based ligand L (L = 1,4-bis(3-(2-pyridyl)pyrazol-1-ylmethyl)benzene) with cis-Ru(bipy)(2)Cl(2)·2H(2)O. They were characterized by elemental analyses, ESI-MS, (1)H spectroscopy, and X-ray crystallography for 2. Compounds 1 and 2 both emit strongly in solid states and in solutions at 298 K with the lifetimes in the microsecond range. Electrogenerated chemiluminescence (ECL) of complexes 1 and 2 in the absence or presence of coreactant tri-n-propylamine (TPrA) or 2-(dibutylamino)ethanol (DBAE) at different working electrodes in acetonitrile and phosphate buffer solutions (PBS, pH 7.5) was studied. The ECL spectra are identical to the photoluminescence spectra, indicating that the ECL emissions are due to the metal to ligand charge transfer (MLCT). In all cases, ECL quantum efficiencies of dinuclear complex 2 are higher than those of mononuclear complex 1, and ECL quantum efficiencies of complexes 1 and 2/TPrA system are higher than those of DBAE system. It is noted that diuretic furosemide tends to decrease the ECL intensity of complex 2/TPrA system in PBS (pH 7.5) at GC working electrode. A novel ECL method for the determination of diuretic furosemide was developed with a linear range between 2.0 × 10(-7) mol L(-1) and 1.0 × 10(-6) mol L(-1), and a detection limit of 1.2 × 10(-8) mol L(-1) based on 3 times the ratio of signal-to-noise.
authors.affiliation: Ministry of Education Key Lab of Analysis and Detection for Food Safety, and Department of Chemistry, Fuzhou University, Fuzhou, 3500108, China. qhw76@fzu.edu.cn
authors.forename: Qiao-Hua
authors.initials: QH
authors.lastname: Wei
authors.forename: Yan-Fang
authors.initials: YF
authors.lastname: Lei
authors.forename: Ya-Nan
authors.initials: YN
authors.lastname: Duan
authors.forename: Fan-Nan
authors.initials: FN
authors.lastname: Xiao
authors.forename: Mei-Jin
authors.initials: MJ
authors.lastname: Li
authors.forename: Guo-Nan
authors.initials: GN
authors.lastname: Chen
mesh_terms: D002082:Butylamines / Q000737:chemistry; D004232:Diuretics / Q000032:analysis* / Q000737:chemistry; D055664:Electrochemical Techniques / Q000379:methods*; D000431:Ethanol / Q000031:analogs & derivatives / Q000737:chemistry; D005665:Furosemide / Q000032:analysis* / Q000737:chemistry; D008024:Ligands; D049408:Luminescent Agents / Q000737:chemistry*; D008163:Luminescent Measurements / Q000379:methods*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D011437:Propylamines / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
chemical_list: D002082:Butylamines; D004232:Diuretics; D008024:Ligands; D049408:Luminescent Agents; D009942:Organometallic Compounds; D011437:Propylamines; C096226:tripropylamine; C517744:2-(dibutylamino)ethanol; D000431:Ethanol; D005665:Furosemide; D012428:Ruthenium