title: Development and Validation of HPTLC Method for the Estimation of Rizatriptan Benzoate in Bulk and Tablets.
abstract: A new, simple high performance thin layer chromatographic method has been proposed for the determination of rizatriptan benzoate in a tablet dosage form. The drug was separated on aluminum plates precoated with silica gel 60 F(254) with dichloromethane-acetone-acetic acid 3:2:0.2(v/v/v) as mobilephase. Quantitative analysis was performed by densitometric scanning at 230 nm. The method was validated for linearity, accuracy, precision and robustness. The calibration plot was linear over the range 200-700 ng/band for rizatriptan benzoate. The method was successfully applied to the analysis of drug in bulk and marketed tablets.
authors.affiliation: Department of Pharmacy, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur - 522 510, India.
authors.forename: B Syama
authors.initials: BS
authors.lastname: Sundar
authors.forename: A
authors.initials: A
authors.lastname: Suneetha