title: Mucosal memory CD8⁺ T cells are selected in the periphery by an MHC class I molecule.
abstract: The presence of immune memory at pathogen-entry sites is a prerequisite for protection. Nevertheless, the mechanisms that warrant immunity at peripheral interfaces are not understood. Here we show that the nonclassical major histocompatibility complex (MHC) class I molecule thymus leukemia antigen (TL), induced on dendritic cells interacting with CD8αα on activated CD8αβ(+) T cells, mediated affinity-based selection of memory precursor cells. Furthermore, constitutive expression of TL on epithelial cells led to continued selection of mature CD8αβ(+) memory T cells. The memory process driven by TL and CD8αα was essential for the generation of CD8αβ(+) memory T cells in the intestine and the accumulation of highly antigen-sensitive CD8αβ(+) memory T cells that form the first line of defense at the largest entry port for pathogens.
authors.affiliation: Division of Developmental Immunology, La Jolla Institute for Allergy & Immunology, La Jolla, California, USA.
authors.forename: Yujun
authors.initials: Y
authors.lastname: Huang
authors.forename: Yunji
authors.initials: Y
authors.lastname: Park
authors.forename: Yiran
authors.initials: Y
authors.lastname: Wang-Zhu
authors.forename: Alexandre
authors.initials: A
authors.lastname: Larange
authors.forename: Ramon
authors.initials: R
authors.lastname: Arens
authors.forename: Iván
authors.initials: I
authors.lastname: Bernardo
authors.forename: Danyvid
authors.initials: D
authors.lastname: Olivares-Villagómez
authors.forename: Dietmar
authors.initials: D
authors.lastname: Herndler-Brandstetter
authors.forename: Ninan
authors.initials: N
authors.lastname: Abraham
authors.forename: Beatrix
authors.initials: B
authors.lastname: Grubeck-Loebenstein
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Schoenberger
authors.forename: Luc
authors.initials: L
authors.lastname: Van Kaer
authors.forename: Mitchell
authors.initials: M
authors.lastname: Kronenberg
authors.forename: Michael A
authors.initials: MA
authors.lastname: Teitell
authors.forename: Hilde
authors.initials: H
authors.lastname: Cheroutre
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology / Q000378:metabolism; D016827:CD8 Antigens / Q000378:metabolism; D002454:Cell Differentiation; D060966:Clonal Selection, Antigen-Mediated; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D018928:Immunity, Mucosal / Q000235:genetics; D007156:Immunologic Memory / Q000235:genetics; D008088:Listeriosis / Q000276:immunology*; D008213:Lymphocyte Activation / Q000235:genetics; D008562:Membrane Glycoproteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D054504:Precursor Cells, T-Lymphoid / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D019076:Transgenes / Q000235:genetics
chemical_list: D000941:Antigens; D016827:CD8 Antigens; C409469:CD8 antigen, alpha chain; D008562:Membrane Glycoproteins; C028388:thymus-leukemia antigens