title: Antiretroviral adherence and the nature of HIV-associated verbal memory impairment.
abstract: The authors investigated the relationship between antiretroviral adherence and HIV-associated verbal memory impairment. HIV-positive participants demonstrated poorer verbal memory than HIV-negative participants. Both good (≥90%) and poor (<90%) adherers displayed encoding deficits as compared with controls, but only poor adherers exhibited retrieval deficits. Encoding deficits primarily accounted for reduced delayed recall in good adherers, but both encoding and retrieval deficits accounted for reduced delayed recall in poor adherers. The retrieval difference between the adherence groups might be explained by a neuroprotective effect of good antiretroviral adherence or preexisting HIV-related retrieval deficits that result in poorer adherence.
authors.affiliation: Psychology Division, Department of Psychiatry, Harbor-UCLA Medical Center, Torrance, CA, USA. mwright@labiomed.org
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Wright
authors.forename: Ellen
authors.initials: E
authors.lastname: Woo
authors.forename: Jessica
authors.initials: J
authors.lastname: Foley
authors.forename: Mark L
authors.initials: ML
authors.lastname: Ettenhofer
authors.forename: Maria E
authors.initials: ME
authors.lastname: Cottingham
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Gooding
authors.forename: Jiah
authors.initials: J
authors.lastname: Jang
authors.forename: Michelle S
authors.initials: MS
authors.lastname: Kim
authors.forename: Steve A
authors.initials: SA
authors.lastname: Castellon
authors.forename: Eric N
authors.initials: EN
authors.lastname: Miller
authors.forename: Charles H
authors.initials: CH
authors.lastname: Hinkin
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000523:psychology; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000209:etiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D010349:Patient Compliance / Q000523:psychology*; D012044:Regression Analysis; D014706:Verbal Learning / Q000502:physiology*
chemical_list: D044966:Anti-Retroviral Agents