title: A facile synthesis of substituted 2-alkylquinolines through [3+3] annulation between 3-ethoxycyclobutanones and aromatic amines at room temperature.
abstract: An efficient single-step approach toward the synthesis of 2-alkylquinolines is described. Through a Lewis acid mediated [3+3] annulation reaction between 3-ethoxycyclobutanones and aromatic amines, a variety of multisubstituted 2-alkylquinoline derivatives were prepared regioselectively at room temperature.
authors.affiliation: Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University, Beijing 100084, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Shan
authors.forename: Xiuyun
authors.initials: X
authors.lastname: Sun
authors.forename: Qian
authors.initials: Q
authors.lastname: Xia
authors.forename: Yu
authors.initials: Y
authors.lastname: Rao
mesh_terms: D000478:Alkylation; D000588:Amines / Q000737:chemistry*; D003503:Cyclobutanes / Q000737:chemistry*; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis*; D013696:Temperature
chemical_list: D000588:Amines; D003503:Cyclobutanes; D011804:Quinolines