title: Administration of harmine and imipramine alters creatine kinase and mitochondrial respiratory chain activities in the rat brain.
abstract: The present study evaluated mitochondrial respiratory chain and creatine kinase activities after administration of harmine (5, 10, and 15 mg/kg) and imipramine (10, 20, and 30 mg/kg) in rat brain. After acute treatment occurred an increase of creatine kinase in the prefrontal with imipramine (20 and 30 mg/kg) and harmine in all doses, in the striatum with imipramine (20 and 30 mg/kg) and harmine (5 and 10 mg/kg); harmine (15 mg/kg) decreased creatine kinase. In the chronic treatment occurred an increase of creatine kinase with imipramine (20 mg/kg), harmine (5 mg/kg) in the prefrontal with imipramine (20 and 30 mg/kg) and harmine (5 and 10 mg/kg) in the striatum. In the acute treatment, the complex I increased in the prefrontal with harmine (15 mg/kg) and in the striatum with harmine (10 mg/kg); the complex II decreased with imipramine (20 and 30 mg/kg) in the striatum; the complex IV increased with imipramine (30 mg/kg) in the striatum. In the chronic treatment, the complex I increased with harmine (5 mg/kg) in the prefrontal; the complex II increased with imipramine (20 mg/kg) in the prefrontal; the complex IV increased with harmine (5 mg/kg) in the striatum. Finally, these findings further support the hypothesis that harmine and imipramine could be involved in mitochondrial function.
authors.affiliation: Laboratório de Neurociências and Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, SC, Brazil.
authors.forename: Gislaine Z
authors.initials: GZ
authors.lastname: Réus
authors.forename: Roberto B
authors.initials: RB
authors.lastname: Stringari
authors.forename: Cinara L
authors.initials: CL
authors.lastname: Gonçalves
authors.forename: Giselli
authors.initials: G
authors.lastname: Scaini
authors.forename: Milena
authors.initials: M
authors.lastname: Carvalho-Silva
authors.forename: Gabriela C
authors.initials: GC
authors.lastname: Jeremias
authors.forename: Isabela C
authors.initials: IC
authors.lastname: Jeremias
authors.forename: Gabriela K
authors.initials: GK
authors.lastname: Ferreira
authors.forename: Emílio L
authors.initials: EL
authors.lastname: Streck
authors.forename: Jaime E
authors.initials: JE
authors.lastname: Hallak
authors.forename: Antônio W
authors.initials: AW
authors.lastname: Zuardi
authors.forename: José A
authors.initials: JA
authors.lastname: Crippa
authors.forename: João
authors.initials: J
authors.lastname: Quevedo