title: Brain metastasis of Wilms tumor with diffuse anaplasia and complex cytogenetic phenotype in a child with neurofibromatosis Type 1.
abstract: The authors report the first case of a Wilms tumor (WT) with diffuse anaplasia metastatic to the brain in a 13-year-old girl with a history of neurofibromatosis Type 1. At presentation, the metastatic tumor had radiological features that suggested a meningioma. Histologically it was characterized by striking anaplasia and features similar to the patient's previously resected WT with diffuse anaplasia.
authors.affiliation: Department of Pathology, New York University, New York, New York 10016, USA. Marianna.Shvartsbeyn@nyumc.org
authors.forename: Marianna
authors.initials: M
authors.lastname: Shvartsbeyn
authors.forename: Luigi
authors.initials: L
authors.lastname: Bassani
authors.forename: Irina
authors.initials: I
authors.lastname: Mikolaenko
authors.forename: Jeffrey H
authors.initials: JH
authors.lastname: Wisoff
mesh_terms: D000293:Adolescent; D000708:Anaplasia / Q000235:genetics; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001254:Astrocytoma / Q000175:diagnosis / Q000628:therapy; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000556:secondary* / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D002648:Child; D002675:Child, Preschool; D003399:Craniotomy; D005260:Female; D006801:Humans; D007029:Hypothalamic Neoplasms / Q000175:diagnosis / Q000628:therapy; D007680:Kidney Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D008279:Magnetic Resonance Imaging / Q000379:methods; D009392:Nephrectomy; D009456:Neurofibromatosis 1 / Q000150:complications* / Q000235:genetics; D019635:Neurosurgical Procedures / Q000379:methods; D010641:Phenotype; D013702:Temporal Lobe / Q000473:pathology / Q000601:surgery; D009396:Wilms Tumor / Q000235:genetics / Q000556:secondary* / Q000628:therapy