title: Three-dimensional imaging of fibrous cap by frequency-domain optical coherence tomography.
abstract: Histopathological data correlated the presence of thin-cap fibroatheroma (TCFA) with adverse cardiovascular events. Intravascular optical coherence tomography (iOCT) is currently the only imaging modality with sufficiently high axial resolution (∼15 μm) that allows direct fibrous-cap (FC) assessment in vivo. iOCT quantification of TCFA has been validated, but the assessment of a single cross-sectional image does not depict the complexity of the atherosclerotic plaque. We present two cases that illustrate the importance of three-dimensional volumetric quantification of the FC capitalizing on the properties of frequency-domain iOCT.
authors.affiliation: Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Hiram G
authors.initials: HG
authors.lastname: Bezerra
authors.forename: Guilherme F
authors.initials: GF
authors.lastname: Attizzani
authors.forename: Marco A
authors.initials: MA
authors.lastname: Costa
mesh_terms: D003324:Coronary Artery Disease / Q000175:diagnosis*; D003331:Coronary Vessels / Q000473:pathology*; D005355:Fibrosis; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000473:pathology*; D012720:Severity of Illness Index; D041623:Tomography, Optical Coherence / Q000379:methods*