title: [The organism tolerance to extreme factors: physiological basis, regulation, prediction].
abstract: The modern ideas about organism reactivity and tolerance, approaches to their estimation and prediction were observed in the paper. The ionizing radiation used as the basic factor, because this factor is the most convenient for the experimental investigation and experimental modeling of the different factors. The individual radiotolerance were observed as the reflection and the component of the organism general nonspecific tolerance. The enough voluminous of different physical factors combined influences were investigated, their reciprocally modified influences to the organism tolerance were estimated. The investigation of mammalian organism tolerance types and tactics of adaptation to the repeated influence of the stress-factors opens the new way to their estimation and prediction. The enough simple and reliable method of the individual tolerance (in particular, with used of the hormonal regulation system indices) were devised. This method is more effective than methods devised earlier.
authors.forename: I B
authors.initials: IB
authors.lastname: Ushakov
authors.forename: A S
authors.initials: AS
authors.lastname: Shtemberg
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology / Q000528:radiation effects; D002490:Central Nervous System / Q000502:physiology / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D008297:Male; D051379:Mice; D008954:Models, Biological; D011836:Radiation Tolerance / Q000235:genetics / Q000502:physiology*; D051381:Rats