title: Health related quality of life and psychosocial correlates among HIV-infected adolescent and young adult women in the US.
abstract: In this study HIV health-related quality of life (HIV-HRQOL) is examined among 179 behaviorally infected adolescent and young adult women. Modifiable psychosocial variables including depression, stigma, social support, and illness acceptance, and the biological end-points of CD4 cell count and viral load were explored in relation to HIV-HRQOL. The three factors of the HIV-HRQOL measure include current life satisfaction, illness related anxiety and illness burden. Bivariate linear regression analysis demonstrated statistically significant associations for all psychosocial variables and HIV HRQOL factors (p < .01), but not for biological end-points. In multivariate linear regression analysis significant associations remained between: depression (p = .006), illness acceptance (p < .001), social support (p = .001), and current life satisfaction, and depression (p = .012), illness acceptance (p = .015), and illness burden. A trend in association was noted for HIV stigma, with current life satisfaction and illness related anxiety but did not reach statistical significance (p = .097 and p = .109 respectively). Interventions that effectively decrease stigma and depression and increase social support and illness acceptance will likely improve the well-being and quality of life of HIV-infected adolescent women.
authors.affiliation: Department of International Health and Development, Tulane School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA. kandrino@tulane.edu
authors.forename: Katherine
authors.initials: K
authors.lastname: Andrinopoulos
authors.forename: Gretchen
authors.initials: G
authors.lastname: Clum
authors.forename: Debra A
authors.initials: DA
authors.lastname: Murphy
authors.forename: Gary
authors.initials: G
authors.lastname: Harper
authors.forename: Lori
authors.initials: L
authors.lastname: Perez
authors.forename: Jiahong
authors.initials: J
authors.lastname: Xu
authors.forename: Shayna
authors.initials: S
authors.lastname: Cunningham
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Ellen
mesh_terms: D000222:Adaptation, Physiological; D000293:Adolescent; D001007:Anxiety / Q000523:psychology; D001294:Attitude to Health; D018791:CD4 Lymphocyte Count / Q000706:statistics & numerical data; D003863:Depression / Q000523:psychology; D005260:Female; D015658:HIV Infections / Q000503:physiopathology* / Q000523:psychology*; D006304:Health Status; D006801:Humans; D011788:Quality of Life / Q000523:psychology*; D012044:Regression Analysis; D057545:Social Stigma; D012944:Social Support; D011795:Surveys and Questionnaires; D014481:United States; D019562:Viral Load / Q000706:statistics & numerical data; D055815:Young Adult