title: Relationship between coronary artery plaque composition by virtual histology intravascular ultrasound analysis and brachial-ankle pulse wave velocity in patients with coronary artery disease.
abstract: OBJECTIVE
  Brachial-ankle pulse wave velocity (baPWV) is an indicator of atherosclerotic cardiovascular risks. To identify patients with coronary atherosclerosis before the onset of angina pectoris or myocardial infarction will be desirable.
  
  
  METHODS
  We measured the ankle-brachial index and baPWV in 150 consecutive patients with coronary artery disease (CAD). Virtual histology intravascular ultrasound (VH-IVUS) imaging was available in target lesions of 130 patients with symptomatic CAD before percutaneous intervention. Patients were divided into two groups: baPWV of greater than or equal to 1600 cm/s (74 patients) and baPWV of less than 1600 cm/s (56 patients).
  
  
  RESULTS
  Patient age was 66±8.33 years in baPWV of greater than or equal to 1600 cm/s group versus 56±10.27 years in baPWV of less than 1600 cm/s group (P<0.0001). Although plaque burden and remodeling index were similar, minimal lumen area was smaller in baPWV of greater than or equal to 1600 cm/s group (P=0.039); and lesion length was longer in the baPWV of greater than or equal to 1600 cm/s group (P=0.033). VH-IVUS analysis of coronary artery plaque composition showed that percent mean and percent maximum dense calcium were higher in the baPWV of greater than or equal to 1600 cm/s group (P=0.0037), and percent maximal calcium correlated with baPWV (r=0.278, P=0.001).
  
  
  CONCLUSIONS
  We concluded that there is a significant relationship between baPWV and the VH-IVUS assessment of CAD. A high baPWV indicates more severe CAD (smaller minimal lumen area and longer lesion length) and greater atherosclerosis disease complexity (more calcified coronary plaque).
authors.affiliation: Heart Center, Chung-Ang University Hospital, Seoul, Korea.
authors.forename: Jee Eun
authors.initials: JE
authors.lastname: Kwon
authors.forename: Gary S
authors.initials: GS
authors.lastname: Mintz
authors.forename: Sang-Wook
authors.initials: SW
authors.lastname: Kim
authors.forename: Min Seok
authors.initials: MS
authors.lastname: Oh
authors.forename: Yun Ju
authors.initials: YJ
authors.lastname: Min
authors.forename: Hyang Kyoung
authors.initials: HK
authors.lastname: Kim
authors.forename: Jae Seung
authors.initials: JS
authors.lastname: Seo
authors.forename: Wang Soo
authors.initials: WS
authors.lastname: Lee
authors.forename: Kwang Je
authors.initials: KJ
authors.lastname: Lee
authors.forename: Tae Ho
authors.initials: TH
authors.lastname: Kim
authors.forename: Chee Jeong
authors.initials: CJ
authors.lastname: Kim
authors.forename: Dai Yun
authors.initials: DY
authors.lastname: Cho
authors.forename: Wang Seong
authors.initials: WS
authors.lastname: Ryu
mesh_terms: D000368:Aged; D055109:Ankle Brachial Index; D001158:Arteries / Q000503:physiopathology*; D003187:Compliance; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D056910:Republic of Korea; D012720:Severity of Illness Index; D018084:Ultrasonography, Interventional; D061205:Vascular Calcification / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology