title: [Effects of electroacupuncture on IL-2-IFN-NKC immunity immunoloregulation net and IL-2 receptor in rats with exercise stress].
abstract: OBJECTIVE
  To explore the effects of electroacupuncture on exercise-induced immunosuppression in rats and its mechanism.
  
  
  METHODS
  Sports immunosuppressive model was established successfully by the rats were conducted high intensity swimming training 150 min/day, 6 days/wk for 8 weeks in this study. Forty-three SD rats were randomly divided into a control group (group A, n = 10), a high intensity swimming training group (group B, n = 17), and a high intensity plus electroacupuncture group (group C, n = 16). Group A did not receive any intervention. Group B was conducted 150 min/day, 6 days/wk swimming training for 8 weeks. Group C was treated with electroacupuncture at "Baihui" (GV 20), "Guanyuan" (CV 4) and "Zusanli" (ST 36) after every exercise-time from the second week, once each day for 7 weeks. The changes of the rats' weight, gamma-interferon (gamma-IFN), interleukin-2 (IL-2), solubility IL-2 receptor (SIL-2R) and nature killer cell (NKC) were detected.
  
  
  RESULTS
  (1) Compared with group A, gamma-IFN and IL-2 in group B were significantly decreased (P < 0.01, P < 0.05), and NKC in group C was significantly increased (P < 0.01). Meanwhile, gamma-IFN and NKC in group C were both significantly higher than that in group B (P < 0.05, P < 0.01). (2) Compared with group A, the weight of the rats in group B and group C were significantly decreased (both P < 0.01), but SIL-2R in group B was significantly increased (P < 0.05). The weight of the rats in group C was significantly higher than that in group B (P < 0.05) and SIL-2R in group C was significantly lower than that in group B (P < 0.01).
  
  
  CONCLUSIONS
  Lasting gravis exercise stress does decrease the immune function in rats and is even inhibited significantly, but electroacupuncture can up-regulate the exercise-induced immunosuppression.
authors.affiliation: Guangzhou University of TCM, Guangzhou 510405, Guangdong Province, China.
authors.forename: Yong-Mei
authors.initials: YM
authors.lastname: Lu
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Chun-Zhi
authors.initials: CZ
authors.lastname: Tang
mesh_terms: D000818:Animals; D015671:Electroacupuncture; D007371:Interferon-gamma / Q000097:blood / Q000502:physiology*; D007376:Interleukin-2 / Q000097:blood / Q000502:physiology*; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male; D010805:Physical Conditioning, Animal; D051381:Rats; D017207:Rats, Sprague-Dawley; D015375:Receptors, Interleukin-2 / Q000097:blood / Q000502:physiology*; D013312:Stress, Physiological / Q000276:immunology*
chemical_list: D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D007371:Interferon-gamma