title: Interferon production by cells infected with subacute sclerosing panencephalitis (SSPE) virus or measles virus.
abstract: BACKGROUND
  Subacute sclerosing panencephalitis (SSPE) is a rare progressive neurodegenerative encephalitis caused by some variants of measles virus (MV). The structure of SSPE virus in the brains of SSPE patients is different from that of MV. The difference in interferon (IFN) production between cells infected with SSPE virus and those infected with MV remains unclear.
  
  
  METHODS
  We measured the concentrations of IFN-α, β, γ, and λ1 (interleukin (IL)-29) from MV- or SSPE virus-infected B95a cells (a marmoset B-lymphoblastoid cell line).
  
  
  RESULTS
  SSPE virus-infected B95a cells produced significantly higher levels of IFN-α and λ1 than did MV-infected or mock-infected cells.
  
  
  CONCLUSIONS
  Our results suggest that SSPE virus and MV induce different IFN production profiles.
authors.affiliation: Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan. shunji@yamaguchi-u.ac.jp
authors.forename: Shunji
authors.initials: S
authors.lastname: Hasegawa
authors.forename: Natsumi
authors.initials: N
authors.lastname: Mori
authors.forename: Mika
authors.initials: M
authors.lastname: Satomi
authors.forename: Da-Peng
authors.initials: DP
authors.lastname: Jiang
authors.forename: Hak
authors.initials: H
authors.lastname: Hotta
authors.forename: Takeshi
authors.initials: T
authors.lastname: Matsushige
authors.forename: Takashi
authors.initials: T
authors.lastname: Ichiyama
mesh_terms: D000818:Animals; D002144:Callithrix; D002460:Cell Line; D016898:Interferon-alpha / Q000378:metabolism; D016899:Interferon-beta / Q000378:metabolism; D007372:Interferons / Q000096:biosynthesis*; D008214:Lymphocytes / Q000276:immunology* / Q000821:virology*; D008459:Measles virus / Q000502:physiology*; D013344:Subacute Sclerosing Panencephalitis / Q000821:virology*; D013347:Subcellular Fractions / Q000378:metabolism
chemical_list: D016898:Interferon-alpha; D016899:Interferon-beta; D007372:Interferons