title: Antioxidant, cytotoxic activities, and structure-activity relationship of gallic acid-based indole derivatives.
abstract: A new series of gallic hydrazones containing an indole moiety was synthesized through the reaction of gallic hydrazide and different indole carboxaldehydes. Their antioxidant activities were determined on DPPH radical scavenging and inhibition of lipid peroxidation. The in-vitro cytotoxic activities of the compounds were evaluated against HCT-116 (human colon cancer cell line) and MCF-7 (estrogen-dependent human breast cancer cell line) by the MTT method. An attempt to correlate the biological results with their structural characteristics has been done. A limited positive structure activity relationship was found between cytotoxic and antioxidant activities.
authors.affiliation: Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia. khaledi@siswa.um.edu.my
authors.forename: Hamid
authors.initials: H
authors.lastname: Khaledi
authors.forename: Abeer A
authors.initials: AA
authors.lastname: Alhadi
authors.forename: Wagee A
authors.initials: WA
authors.lastname: Yehye
authors.forename: Hapipah Mohd
authors.initials: HM
authors.lastname: Ali
authors.forename: Mahmood A
authors.initials: MA
authors.lastname: Abdulla
authors.forename: Pouya
authors.initials: P
authors.lastname: Hassandarvish
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000473:pathology; D005260:Female; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D005707:Gallic Acid / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045325:HCT116 Cells; D006801:Humans; D006835:Hydrazones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D016166:Free Radical Scavengers; D006835:Hydrazones; D007211:Indoles; D005707:Gallic Acid