title: Determinants and risk factors for central corneal thickness in Japanese persons: the Funagata Study.
abstract: OBJECTIVE
  To examine the association between glucose metabolism and central corneal thickness (CCT) in Japanese adults.
  
  
  METHODS
  A sub-sample of 322 Japanese adults participating in the Funagata Study was included in this analysis. CCT was measured using a specular microscope. Glucose metabolism was examined using 75-g oral glucose tolerance test. Mean differences in CCT (μm) and 95% confidence intervals were estimated with univariate, age-sex-adjusted and multivariate models using multiple linear regression.
  
  
  RESULTS
  The mean (± standard deviation) age of the study sample was 63.7 ± 11.4 years and 44% were men. The mean fasting plasma glucose (FPG), 2-hour post-load plasma glucose (2hPG) and haemoglobin A1c (HbA1c) concentrations were 96.8 ± 12.6mg/dl, 123.6 ± 41.2mg/dl and 5.3 ± 0.4%, respectively. CCT was normally distributed in the study sample, and the mean CCT was 544.7 ± 34.6μm. After multivariate adjustment, characteristics associated with increased CCT were 2hPG and HbA1c concentrations, impaired glucose tolerance, diabetes, body weight or body mass index and current smoking.
  
  
  CONCLUSIONS
  Impaired glucose tolerance, diabetes, obesity and current smoking are associated with increased CCT. Additional studies are required to examine whether interventions to affect these characteristics may reduce CCT.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Yamagata University Faculty of Medicine, Yamagata, Japan. mlc12186@nifty.com
authors.forename: Koichi
authors.initials: K
authors.lastname: Nishitsuka
authors.forename: Ryo
authors.initials: R
authors.lastname: Kawasaki
authors.forename: Makoto
authors.initials: M
authors.lastname: Kanno
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Tanabe
authors.forename: Koko
authors.initials: K
authors.lastname: Saito
authors.forename: Kei
authors.initials: K
authors.lastname: Honma
authors.forename: Toshihide
authors.initials: T
authors.lastname: Oizumi
authors.forename: Makoto
authors.initials: M
authors.lastname: Daimon
authors.forename: Takeo
authors.initials: T
authors.lastname: Kato
authors.forename: Takamasa
authors.initials: T
authors.lastname: Kayama
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Yamashita
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D003315:Cornea / Q000033:anatomy & histology*; D003920:Diabetes Mellitus / Q000503:physiopathology; D005260:Female; D018149:Glucose Intolerance / Q000503:physiopathology; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin