title: Integrative, multimodal analysis of glioblastoma using TCGA molecular data, pathology images, and clinical outcomes.
abstract: Multimodal, multiscale data synthesis is becoming increasingly critical for successful translational biomedical research. In this letter, we present a large-scale investigative initiative on glioblastoma, a high-grade brain tumor, with complementary data types using in silico approaches. We integrate and analyze data from The Cancer Genome Atlas Project on glioblastoma that includes novel nuclear phenotypic data derived from microscopic slides, genotypic signatures described by transcriptional class and genetic alterations, and clinical outcomes defined by response to therapy and patient survival. Our preliminary results demonstrate numerous clinically and biologically significant correlations across multiple data types, revealing the power of in silico multimodal data integration for cancer research.
authors.affiliation: Center for Comprehensive Informatics, Emory University, Atlanta, GA 30322, USA. jun.kong@emory.edu
authors.forename: Jun
authors.initials: J
authors.lastname: Kong
authors.forename: Lee A D
authors.initials: LA
authors.lastname: Cooper
authors.forename: Fusheng
authors.initials: F
authors.lastname: Wang
authors.forename: David A
authors.initials: DA
authors.lastname: Gutman
authors.forename: Jingjing
authors.initials: J
authors.lastname: Gao
authors.forename: Candace
authors.initials: C
authors.lastname: Chisolm
authors.forename: Ashish
authors.initials: A
authors.lastname: Sharma
authors.forename: Tony
authors.initials: T
authors.lastname: Pan
authors.forename: Erwin G
authors.initials: EG
authors.lastname: Van Meir
authors.forename: Tahsin M
authors.initials: TM
authors.lastname: Kurc
authors.forename: Carlos S
authors.initials: CS
authors.lastname: Moreno
authors.forename: Joel H
authors.initials: JH
authors.lastname: Saltz
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Brat
mesh_terms: D001271:Atlases as Topic; D001932:Brain Neoplasms / Q000235:genetics / Q000473:pathology*; D016000:Cluster Analysis; D019295:Computational Biology / Q000379:methods*; D003198:Computer Simulation; D003628:Database Management Systems; D016208:Databases, Factual; D020869:Gene Expression Profiling; D005838:Genotype; D005909:Glioblastoma / Q000235:genetics / Q000473:pathology*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008853:Microscopy; D010641:Phenotype