title: In vitro activity of tedizolid (TR-700) against linezolid-resistant staphylococci.
abstract: OBJECTIVE
  To compare the activity of tedizolid (formally known as torezolid and TR-700) with that of 15 agents against a collection of linezolid-resistant staphylococci (164 coagulase-negative staphylococci and 5 Staphylococcus aureus).
  
  
  METHODS
  Antimicrobial susceptibility tests were performed using the broth microdilution method following the recommendations of the CLSI.
  
  
  RESULTS
  All isolates were susceptible to vancomycin and tigecycline. Based on the MIC(90) values, the potency of tedizolid against coagulase-negative staphylococci was >16-fold greater than that of linezolid. Tedizolid retained activity against most of the linezolid-resistant staphylococci tested, including multidrug-resistant isolates with elevated linezolid MICs (32 to >128 mg/L). Of the isolates, 79.2% and 31.4% were inhibited by tedizolid at ≤ 4 mg/L and ≤ 2 mg/L, respectively.
  
  
  CONCLUSIONS
  The results of this study confirm the activity of tedizolid against linezolid-resistant staphylococci. This new oxazolidinone could have an important role as a potential therapeutic agent against multidrug-resistant staphylococci.
authors.affiliation: Servicio de Microbiología Clínica, Hospital Clínico San Carlos, Plaza Cristo Rey s/n, 28040 Madrid, Spain. irodriguezi.hcsc@salud.madrid.org
authors.forename: Iciar
authors.initials: I
authors.lastname: Rodríguez-Avial
authors.forename: Esther
authors.initials: E
authors.lastname: Culebras
authors.forename: Carmen
authors.initials: C
authors.lastname: Betriu
authors.forename: Gracia
authors.initials: G
authors.lastname: Morales
authors.forename: Irene
authors.initials: I
authors.lastname: Pena
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Picazo
mesh_terms: D000081:Acetamides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006801:Humans; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000494:pharmacology*; D013203:Staphylococcal Infections; D013210:Staphylococcus / Q000187:drug effects* / Q000302:isolation & purification; D013777:Tetrazoles / Q000494:pharmacology*
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D013777:Tetrazoles; C546016:tedizolid; D000069349:Linezolid