title: [Maculo-papular exanthem with acute renal failure. Drug-induced hypersensitivity syndrome].
abstract: Acute renal failure caused by interstitial nephritis as part of a drug hypersensitivity syndrome constitutes a rare, but potentially life-threatening adverse drug reaction. We describe a patient with a mild maculo-papular rash accompanied by eosinophilia after prolonged treatment with meropenem, vancomycin, and moxifloxacin. Subsequently, a rapidly progressing renal failure developed which dominated the clinical picture. Upon cessation of all suspected drugs and therapy with high-dose steroids for 6 weeks, the renal function slowly returned to normal.
authors.affiliation: Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Würzburg, Josef-Schneider-Str. 2, 97080, Würzburg, Deutschland. Tuezolto@hotmail.com
authors.forename: P A
authors.initials: PA
authors.lastname: Müller
authors.forename: K
authors.initials: K
authors.lastname: Amann
authors.forename: E-B
authors.initials: EB
authors.lastname: Bröcker
authors.forename: A
authors.initials: A
authors.lastname: Trautmann
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001021:Aortic Valve; D001372:Aza Compounds / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D004359:Drug Therapy, Combination; D004697:Endocarditis, Bacterial / Q000188:drug therapy; D004802:Eosinophilia / Q000139:chemically induced; D024841:Fluoroquinolones; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007877:Legionnaires' Disease / Q000188:drug therapy; D008297:Male; D000077731:Meropenem; D000077266:Moxifloxacin; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D011804:Quinolines / Q000009:adverse effects* / Q000627:therapeutic use; D018805:Sepsis / Q000188:drug therapy; D012867:Skin / Q000187:drug effects / Q000473:pathology; D013845:Thienamycins / Q000009:adverse effects* / Q000627:therapeutic use; D014640:Vancomycin / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D005938:Glucocorticoids; D011804:Quinolines; D013845:Thienamycins; D014640:Vancomycin; D000077731:Meropenem; D000077266:Moxifloxacin