title: Expeditious diastereoselective construction of a thiochroman skeleton via a cinchona alkaloid-derived catalyst.
abstract: An example of diastereoselective and enantioselective synthesis of thiochroman derivatives through a sulfa-Michael-Michael cascade sequence is disclosed. This is a significant complement of the quinine-thiourea catalyzed sulfa-Michael-Michael cascade reaction. The densely functionalized target thiochromans were obtained in high diastereoselectivities, and with high to excellent enantioselectivities.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
authors.forename: Zhiyun
authors.initials: Z
authors.lastname: Du
authors.forename: Chenggang
authors.initials: C
authors.lastname: Zhou
authors.forename: Yaojun
authors.initials: Y
authors.lastname: Gao
authors.forename: Qiao
authors.initials: Q
authors.lastname: Ren
authors.forename: Kun
authors.initials: K
authors.lastname: Zhang
authors.forename: Hansong
authors.initials: H
authors.lastname: Cheng
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
mesh_terms: D002384:Catalysis; D002839:Chromans / Q000737:chemistry*; D002930:Cinchona Alkaloids / Q000737:chemistry*; D008958:Models, Molecular; D013237:Stereoisomerism
chemical_list: D002839:Chromans; D002930:Cinchona Alkaloids