title: Meta-analysis of wavefront-guided vs. wavefront-optimized LASIK for myopia.
abstract: OBJECTIVE
  To detect possible differences in clinical outcomes between wavefront-guided laser in situ keratomileusis (LASIK) and wavefront-optimized LASIK for the treatment of myopia.
  
  
  METHODS
  A comprehensive literature search of Cochrane Library, MEDLINE, and EMBASE to identify relevant trials comparing LASIK with wavefront-guided and wavefront-optimized. A meta-analysis was performed on the results of the reports. Statistical analysis was performed using RevMan 5.0 software.
  
  
  RESULTS
  Seven articles describing a total of 930 eyes were identified. There were no statistically significant differences in the final proportion of eyes achieving uncorrected distance visual acuity of 20/20 or better [odds ratio, 1.04; 95% confidence interval (CI), 0.66 to 1.65; p = 0.86], manifest refractive spherical equivalent within ± 0.50 D of the target (odds ratio, 0.96; 95% CI, 0.53 to 1.75; p = 0.90). No patient lost ≥ 2 lines of distance-corrected visual acuity at posttreatment. The changes in higher order aberrations were not statistically significant different between the two groups with preoperative root-mean-square (RMS) higher order aberrations <0.3 μm (weighted mean difference, 0.01; 95% CI, -0.02 to 0.04; p = 0.57). However, wavefront-guided had a significant better postoperative aberration profile than wavefront-optimized with preoperative RMS higher order aberrations >0.3 μm (weighted mean difference, -0.10; 95% CI, -0.15 to -0.06; p < 0.00001).
  
  
  CONCLUSIONS
  Both wavefront-guided and wavefront-optimized LASIK have shown excellent efficacy, safety, and predictability. The wavefront-guided technology may be a more appropriate choice for patients who have preoperative RMS higher order aberrations >0.3 μm.
authors.affiliation: School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang Province, China.
authors.forename: Yifan
authors.initials: Y
authors.lastname: Feng
authors.forename: Jiguo
authors.initials: J
authors.lastname: Yu
authors.forename: Qinmei
authors.initials: Q
authors.lastname: Wang
mesh_terms: D057108:Corneal Wavefront Aberration / Q000517:prevention & control*; D006801:Humans; D020731:Keratomileusis, Laser In Situ / Q000379:methods*; D009216:Myopia / Q000503:physiopathology / Q000601:surgery*; D012029:Refraction, Ocular / Q000502:physiology*; D016896:Treatment Outcome; D014792:Visual Acuity