title: Identification of γ-AApeptides with potent and broad-spectrum antimicrobial activity.
abstract: We report the identification of a new class of antimicrobial peptidomimetics-γ-AApeptides with potent and broad-spectrum activity, including clinically-relevant strains that are unresponsive to most antibiotics. They are also not prone to select for drug-resistance.
authors.affiliation: Department of Chemistry, University of South Florida, 4202 E. Fowler Ave, Tampa, FL 33620, USA. jianfengcai@usf.edu; ; Tel: +1-813-974-9506.
authors.forename: Youhong
authors.initials: Y
authors.lastname: Niu
authors.affiliation: Department of Chemistry, University of South Florida, 4202 E. Fowler Ave, Tampa, FL 33620, USA. jianfengcai@usf.edu; ; Tel: +1-813-974-9506.
authors.forename: Shruti
authors.initials: S
authors.lastname: Padhee
authors.affiliation: Department of Chemistry, University of South Florida, 4202 E. Fowler Ave, Tampa, FL 33620, USA. jianfengcai@usf.edu; ; Tel: +1-813-974-9506.
authors.forename: Haifan
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Chemistry, University of South Florida, 4202 E. Fowler Ave, Tampa, FL 33620, USA. jianfengcai@usf.edu; ; Tel: +1-813-974-9506.
authors.forename: Ge
authors.initials: G
authors.lastname: Bai
authors.affiliation: Department of Cell Biology, Microbiology and Molecular Biology, 4202 E. Fowler Ave, Tampa, FL 33620, USA.
authors.forename: Lacey
authors.initials: L
authors.lastname: Harrington
authors.affiliation: Department of Cell Biology, Microbiology and Molecular Biology, 4202 E. Fowler Ave, Tampa, FL 33620, USA.
authors.forename: Whittney N
authors.initials: WN
authors.lastname: Burda
authors.affiliation: Department of Cell Biology, Microbiology and Molecular Biology, 4202 E. Fowler Ave, Tampa, FL 33620, USA.
authors.forename: Lindsey N
authors.initials: LN
authors.lastname: Shaw
authors.affiliation: Department of Molecular Pharmacology and Physiology, USF-Health Byrd Alzheimer's Institute, 4001 E. Fletcher Ave, Tampa, FL 33613, USA.
authors.forename: Chuanhai
authors.initials: C
authors.lastname: Cao
authors.affiliation: Department of Chemistry, University of South Florida, 4202 E. Fowler Ave, Tampa, FL 33620, USA. jianfengcai@usf.edu; ; Tel: +1-813-974-9506.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Cai
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000138:chemical synthesis / Q000494:pharmacology*; D040761:Biomimetic Materials; D002176:Candida albicans / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects; D024901:Drug Resistance, Multiple, Bacterial; D004926:Escherichia coli / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008826:Microbial Sensitivity Tests
chemical_list: D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides