title: Characteristics of patients registered with chronic renal disease in Castilla y León and survival analysis of transplanted patients and their grafts.
abstract: BACKGROUND
  Chronic kidney disease (CKD) is an important public health problem. Kidney transplantation is associated with increase survival and improvement of quality of life.
  
  
  OBJECTIVE
  To describe the sociodemographic and clinical characteristics of patients registered in Castilla y León. To perform a survival analysis of transplant patients and their grafts. To evaluate survival depending on the transplant centre.
  
  
  METHODS
  Descriptive study with data collected until 31 December 2008 from the Registro de Diálisis y Trasplante Renal de la Comunidad de Castilla y León (REDI). The data was described differentiating prevalent and incidents patients. Survival data was assessed with the Kaplan-Meier method.
  
  
  RESULTS
  On 31 December 2008, 2.498 patients were on Renal Replacement Therapy (RRT) (976.8 pmp); in 2008, 337 started treatment (131.8 pmp) and 94 received kidney transplant (36.8 pmp). The first cause of CKD for incident patients is diabetes (25.0%), followed by vascular diseases (18.1%). For prevalent patients: glomerulonephritis (16.5%) and diabetes (14.4%). Differences (p = 0.0021) were observed for the treatment initiation age, group of disease and prevalent patients (p <0.0001). During 11 years 1.062 transplants were performed in 1.012 patients and 879 are still functioning (83%). In this period, the survival probability for the transplant patients is 81.076% (± 0.023), and for the 838 patients with first functioning graft is 89.336% (± 0.016). Median graft survival is between 8.7 and 9.3 years (95% confidence).
  
  
  CONCLUSIONS
  Most of the transplants during the last 11 years are still functioning. There are no differences when comparing graft survival at the approved centers in Castilla y León (p = 0.358).
authors.affiliation: Statistics Department, Health Department of the Autonomous Community of Castilla y León, Valladolid, Spain. dordiaan@jcyl.es
authors.forename: A
authors.initials: A
authors.lastname: Dorado Díaz
authors.forename: C
authors.initials: C
authors.lastname: Estébanez Álvarez
authors.forename: P
authors.initials: P
authors.lastname: Martín Pérez
authors.forename: C
authors.initials: C
authors.lastname: Fernández Renedo
authors.forename: R
authors.initials: R
authors.lastname: González Fernández
authors.forename: M P
authors.initials: MP
authors.lastname: Galindo Villardón
authors.forename: J C
authors.initials: JC
authors.lastname: Espinosa Gutiérrez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003928:Diabetic Nephropathies / Q000453:epidemiology / Q000601:surgery; D005260:Female; D005921:Glomerulonephritis / Q000453:epidemiology / Q000601:surgery; D006085:Graft Survival; D006761:Hospitals / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D007674:Kidney Diseases / Q000453:epidemiology* / Q000601:surgery; D016030:Kidney Transplantation / Q000401:mortality / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012042:Registries; D013030:Spain / Q000453:epidemiology; D055815:Young Adult