title: [Autoantibodies in GAD65 in Mexican adults with diabetes types 1 and 2 and their siblings].
abstract: BACKGROUND
  Pancreatic cell destruction causing type 1 diabetes is associated to diverse autoantibodies. Antibodies against glutamic acid decarboxylase have been found in type 1 (DM1) and type 2 diabetic patients (DM2). Their presence in siblings is unknown.
  
  
  OBJECTIVE
  To determine the presence of anti-GAD65 autoantibodies in diabetic patients and their siblings.
  
  
  METHODS
  Sixty-eight individuals were included and distributed in four groups: group 1 DM1, group 2 DM2, group 3 and 4 healthy siblings of patients from groups 1 and 2. Anti-GAD65, peptide C, serum glucose, total cholesterol and triglycerides were obtained. Body mass index and hip-waist ratio were measured.
  
  
  RESULTS
  Anti-GAD65 antibodies were positive in 23% of DM1, in 14% of DM2, and in 7.7% and 9.5% in siblings of both groups, respectively. Using Mann-Whitney's U the mean of anti-GAD65 in diabetic type 1 and 2 patients was p = 0.022; between DM1 and their siblings and between DM2 and their siblings there was no statistical significance. C peptide was low in cases of positive anti-GAD65 of DM1 and DM2; and it was normal in patients with negative anti-GAD65.
  
  
  CONCLUSIONS
  Anti-GAD65 autoantibodies are more frequent in type 1 diabetic patients. There were no meaningful differences regarding the presence of anti-GAD65 in patients and their siblings.
authors.affiliation: Servicio de Alergia e Inmunología Clínica, Unidad Médica de Alta Especialidad, Hospital de Especialidades Dr. Antonio Fraga Mouret, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, México, DF, Mexico. mbecer5@gmail.com.
authors.forename: Martín
authors.initials: M
authors.lastname: Becerril Ángeles
authors.forename: Sergio Enrique
authors.initials: SE
authors.lastname: García Lara
authors.forename: David
authors.initials: D
authors.lastname: González Bárcena
authors.forename: María Alicia
authors.initials: MA
authors.lastname: Ibarra Olmos
authors.forename: Pedro
authors.initials: P
authors.lastname: Torres Ambriz
authors.forename: Ulises
authors.initials: U
authors.lastname: Angeles Garay
mesh_terms: D000328:Adult; D001323:Autoantibodies; D002096:C-Peptide; D003922:Diabetes Mellitus, Type 1; D005968:Glutamate Decarboxylase; D006801:Humans; D035781:Siblings
chemical_list: D001323:Autoantibodies; D002096:C-Peptide; D005968:Glutamate Decarboxylase