title: Synthesis and anticonvulsant activity of a new series of 1,4-dihydropyridine derivatives.
abstract: A series of 1,4-dihydropyridine derivatives (1a-g) were prepared from three compounds condensation of Hantzsch synthesis. A new series of 2,2'-{[4-(aryl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl]dicarbonyl}dihydrazinecarbothioamide (2a-g) were prepared from compounds diethyl 4-(aryl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (1a-g) reacted with thiosemicarbazide to give the corresponding compounds (2a-g) by hydrazinolysis method. The synthesized compounds were confirmed by IR, (1)HNMR, (13)CNMR, mass spectral and elemental analyses. The newly synthesized compounds (2a-g) were screened for anticonvulsant activity against in swiss albino rat. The test was evaluated by maximal electrode induced convulsion method. Synthesized compounds were used two (50 and 100 mg/kg) concentrations. Compounds (1a-g) were inactive while compounds (2a-g) have moderate anti-convulsant activity compared with standard phenytoin drug. The compound 2,2'-{[4-(furan-2-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl]dicarbonyl} dihydrazinecarbothioamide (2a) has highly active compared with other compound (2b-2g).
authors.affiliation: P. G. and Research Department of Chemistry, Jamal Mohamed College, Tiruchirappalli - 620 020, India.
authors.forename: R Surendra
authors.initials: RS
authors.lastname: Kumar
authors.forename: A
authors.initials: A
authors.lastname: Idhayadhulla
authors.forename: A Jamal Abdul
authors.initials: AJ
authors.lastname: Nasser
authors.forename: S
authors.initials: S
authors.lastname: Kavimani
authors.forename: S
authors.initials: S
authors.lastname: Indumathy