title: CD8 T cells and E-cadherin in host responses against oropharyngeal candidiasis.
abstract: BACKGROUND
  Oropharyngeal candidiasis (OPC) is the most common oral infection in HIV(+) persons. Previous studies suggest a role for CD8(+) T cells against OPC when CD4(+) T cells are lost, but enhanced susceptibility to infection occurs when CD8(+) T-cell migration is inhibited by reduced tissue E-cadherin.
  
  
  OBJECTIVE
  To conduct a longitudinal study of tissue CD8(+) T-cells and E-cadherin expression before, during, and after the episodes of OPC.
  
  
  METHODS
  Oral fungal burden was monitored and tissue was evaluated for CD8(+) T cells and E-cadherin over a 1-year period in HIV(+) persons with a history of, or an acute episode of, OPC.
  
  
  RESULTS
  While longitudinal analyses precluded formal interpretations, point prevalence analyses of the data set revealed that when patients experiencing OPC were successfully treated, tissue E-cadherin expression was similar to that in patients who had not experienced OPC, and higher numbers of CD8(+) T cells were distributed throughout OPC(-) tissue under normal expression of E-cadherin.
  
  
  CONCLUSIONS
  These results suggest that (1) reduction in tissue E-cadherin expression in patients with OPC(+) is not permanent, and (2) high numbers of CD8(+) T cells can be distributed throughout OPC(-) tissue under normal E-cadherin expression. Together, these results extend our previous studies and continue to support a role for CD8(+) T cells in host defense against OPC.
authors.affiliation: Department of Oral and Craniofacial Biology, Louisiana State University Health Sciences, Center School of Dentistry, New Orleans, LA, USA.
authors.forename: K
authors.initials: K
authors.lastname: Quimby
authors.forename: E A
authors.initials: EA
authors.lastname: Lilly
authors.forename: M
authors.initials: M
authors.lastname: Zacharek
authors.forename: K
authors.initials: K
authors.lastname: McNulty
authors.forename: J E
authors.initials: JE
authors.lastname: Leigh
authors.forename: J E
authors.initials: JE
authors.lastname: Vazquez
authors.forename: P L
authors.initials: PL
authors.lastname: Fidel
mesh_terms: D000328:Adult; D001741:Black or African American; D000704:Analysis of Variance; D000935:Antifungal Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D015820:Cadherins / Q000096:biosynthesis* / Q000502:physiology; D002175:Candida / Q000302:isolation & purification; D002180:Candidiasis, Oral / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D002465:Cell Movement; D015169:Colony Count, Microbial; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D016130:Immunophenotyping; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000276:immunology / Q000382:microbiology; D012463:Saliva / Q000276:immunology / Q000382:microbiology; D018709:Statistics, Nonparametric
chemical_list: D000935:Antifungal Agents; D015820:Cadherins