title: Histological correlation of glandular abnormalities in cervical liquid-based cytology.
abstract: Conventional Papanicolaou smear method is still commonly used for cervical cancer screening in Japan, despite the liquid-based cytology (LBC) that has become a global tendency in the world recently. One of the obstacles in the way of popularization of this method seems to be the confusion as to diagnosis upon cervical glandular lesions. We performed comparison study between LBC and conventional Papanicolaou smear about cytological diagnosis using split-sample method in 4522 patients. In 13 cases analyses, which were reported with either AGC or adenocarcinoma by either method, LBC tends to be milder than that by conventional smear, however, the credibility of LBC is considered to be near to that of conventional smear with regard to screening for glandular abnormalities. These results indicate that cervical cancer screening should shift to LBC under the enough experience and appropriate dealing with the cytological diagnosis.
authors.affiliation: Institute for Clinical Research, National Hospital Organization Japan, Kure Medical Center/Chugoku Cancer Center, 3-1 Aoyama-Cho, Kure-City, Hiroshima 737-0023, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Kawakami
authors.forename: Tamaki
authors.initials: T
authors.lastname: Toda
authors.forename: Toshinao
authors.initials: T
authors.lastname: Nishimura
authors.forename: Junichi
authors.initials: J
authors.lastname: Sakane
authors.forename: Kazuya
authors.initials: K
authors.lastname: Kuraoka
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Takehara
authors.forename: Tomoya
authors.initials: T
authors.lastname: Mizunoe
authors.forename: Kiyomi
authors.initials: K
authors.lastname: Taniyama