title: Resolution of 2-nitroalcohols by Burkholderia cepacia lipase-catalyzed enantioselective acylation.
abstract: Racemic 2-nitro-1-phenylethanol was resolved by via enantioselective transesterification catalyzed by Burkholderia cepacia lipase. The reaction afforded excellent E values (E > 200) and enantioselectivity (up to >99% enantiomeric excesses [ee]) of both remaining substrates and acetylated product. Moreover, the lipase displayed high enantioselectivity in the resolution of additional 2-nitroalcohols (E up to >200). This method provides an efficient alternative for obtaining enantiopure 2-nitroalcohols.
authors.affiliation: Division of Microbiology, College of Life Sciences, Northwest A&F University, Yangling, 712100, Shaanxi, China.
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.forename: Shi-Bin
authors.initials: SB
authors.lastname: Hu
authors.forename: Gui-Ying
authors.initials: GY
authors.lastname: Feng
mesh_terms: D000215:Acylation; D001592:Benzyl Alcohols / Q000737:chemistry / Q000378:metabolism*; D016956:Burkholderia cepacia / Q000201:enzymology* / Q000378:metabolism*; D008049:Lipase / Q000378:metabolism*; D009574:Nitro Compounds / Q000737:chemistry / Q000378:metabolism*; D013237:Stereoisomerism
chemical_list: D001592:Benzyl Alcohols; D009574:Nitro Compounds; C002017:methylphenyl carbinol; D008049:Lipase