title: The convergence of cochlear implantation with induced pluripotent stem cell therapy.
abstract: According to 2010 estimates from The National Institute on Deafness and other Communication Disorders, approximately 17% (36 million) American adults have reported some degree of hearing loss. Currently, the only clinical treatment available for those with severe-to-profound hearing loss is a cochlear implant, which is designed to electrically stimulate the auditory nerve in the absence of hair cells. Whilst the cochlear implant has been revolutionary in terms of providing hearing to the severe-to-profoundly deaf, there are variations in cochlear implant performance which may be related to the degree of degeneration of auditory neurons following hearing loss. Hence, numerous experimental studies have focused on enhancing the efficacy of cochlear implants by using neurotrophins to preserve the auditory neurons, and more recently, attempting to replace these dying cells with new neurons derived from stem cells. As a result, several groups are now investigating the potential for both embryonic and adult stem cells to replace the degenerating sensory elements in the deaf cochlea. Recent advances in our knowledge of stem cells and the development of induced pluripotency by Takahashi and Yamanaka in 2006, have opened a new realm of science focused on the use of induced pluripotent stem (iPS) cells for therapeutic purposes. This review will provide a broad overview of the potential benefits and challenges of using iPS cells in combination with a cochlear implant for the treatment of hearing loss, including differentiation of iPS cells into an auditory neural lineage and clinically relevant transplantation approaches.
authors.affiliation: Department of Otolaryngology, University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Niliksha
authors.initials: N
authors.lastname: Gunewardene
authors.forename: Mirella
authors.initials: M
authors.lastname: Dottori
authors.forename: Bryony A
authors.initials: BA
authors.lastname: Nayagam
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002470:Cell Survival; D003051:Cochlea / Q000473:pathology; D019929:Cochlear Implantation; D003056:Cochlear Nerve / Q000473:pathology; D003131:Combined Modality Therapy; D006319:Hearing Loss, Sensorineural / Q000628:therapy*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000502:physiology / Q000637:transplantation*; D009474:Neurons / Q000502:physiology; D044968:Regenerative Medicine