title: Role of corticotropin-releasing factor in the median raphe nucleus in yohimbine-induced reinstatement of alcohol seeking in rats.
abstract: The pharmacological stressor yohimbine increases ongoing alcohol self-administration and reinstates alcohol seeking in rats. This effect is attenuated by systemic injections of a corticotropin-releasing factor (CRF) antagonist. The brain sites involved in CRF's role in yohimbine-induced alcohol taking and seeking are unknown. We report that injections of the CRF receptor antagonist d-Phe CRF into the median raphe nucleus (MRN) attenuated yohimbine-induced reinstatement of alcohol seeking but had no effect on yohimbine-induced increases in alcohol intake during ongoing self-administration. Results indicate an important role of MRN CRF receptors in yohimbine-induced reinstatement of alcohol seeking but not yohimbine-induced increases in alcohol intake.
authors.affiliation: Neurobiology of Alcohol Laboratory, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, ON, Canada. anh_le@camh.net
authors.forename: A D
authors.initials: AD
authors.lastname: Lê
authors.forename: Douglas
authors.initials: D
authors.lastname: Funk
authors.forename: Kathleen
authors.initials: K
authors.lastname: Coen
authors.forename: Zhaoxia
authors.initials: Z
authors.lastname: Li
authors.forename: Yavin
authors.initials: Y
authors.lastname: Shaham
mesh_terms: D000818:Animals; D002492:Central Nervous System Depressants / Q000008:administration & dosage*; D003346:Corticotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000502:physiology*; D058999:Drug-Seeking Behavior / Q000187:drug effects*; D000431:Ethanol / Q000008:administration & dosage*; D008297:Male; D011903:Raphe Nuclei / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012054:Reinforcement, Psychology; D012646:Self Administration; D015016:Yohimbine / Q000494:pharmacology*
chemical_list: D002492:Central Nervous System Depressants; C482465:phenylalanyl corticotropin-releasing factor; D015016:Yohimbine; D000431:Ethanol; D003346:Corticotropin-Releasing Hormone