title: Ki 67 is a major, but not the sole determinant of Oncotype Dx recurrence score.
abstract: BACKGROUND
  Immunohistological assessment of Ki 67 expression is less expensive than Oncotype Dx, which is currently used to identify patients with lymph node-negative breast cancer, who will benefit from adjuvant chemotherapy.
  
  
  METHODS
  The relationship of immunohistologically measured Ki 67 to Oncotype DX recurrence score (RS) was examined in 53 cases of T1-2 N0 M0 (oestrogen receptor-positive, HER2/neu negative) breast cancer.
  
  
  RESULTS
  There was a strong linear correlation between Ki 67 value and the Oncotype Dx RS. All patients in the low Ki 67 group (Ki 67 of ≤ 10%) had Oncotype Dx RSs of low or intermediate risk. The vast majority of patients (93.8%) in the high-Ki 67 group (Ki 67 ≥ 25%) had oncotype RSs of high or intermediate risk.
  
  
  CONCLUSIONS
  Ki 67 proliferation value is a major, but not the sole determinant of Oncotype Dx score.
authors.affiliation: Department of Medical Oncology, Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Sahebjam
authors.forename: R
authors.initials: R
authors.lastname: Aloyz
authors.forename: D
authors.initials: D
authors.lastname: Pilavdzic
authors.forename: M-L
authors.initials: ML
authors.lastname: Brisson
authors.forename: C
authors.initials: C
authors.lastname: Ferrario
authors.forename: N
authors.initials: N
authors.lastname: Bouganim
authors.forename: V
authors.initials: V
authors.lastname: Cohen
authors.forename: W H
authors.initials: WH
authors.lastname: Miller
authors.forename: L C
authors.initials: LC
authors.lastname: Panasci
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism*; D017024:Chemotherapy, Adjuvant; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism*; D011237:Predictive Value of Tests; D011379:Prognosis; D060888:Real-Time Polymerase Chain Reaction / Q000379:methods; D012008:Recurrence
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen