title: Cross-link immunoprecipitation data to detect polymorphisms lying in splicing regulatory motifs:  a method to refine single nucleotide polymorphism selection in association studies.
abstract: In a previous study we showed that prediction tools are useful to select single-nucleotide polymorphisms (SNPs) which potentially affect phenotype and therefore guide genotyping in association studies, thus saving time and money. Here we use the recently available RNA cross-link immunoprecipitation data to analyze several genes involved in psychiatric disorders and show which disease-associated SNPs can affect the splicing process by altering splicing factor binding sites. We point out the importance of using cross-link immunoprecipitation data in psychiatry to refine the SNP selection methods, to explain the association found and to plan molecular investigations.
authors.affiliation: Department of Specialized Clinical Sciences and Odontostomatology, Polytechnic University of Marche, via Brecce Bianche, Ancona, Italy. f.piva@univpm.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Piva
authors.forename: Matteo
authors.initials: M
authors.lastname: Giulietti
authors.forename: Tatiana
authors.initials: T
authors.lastname: Armeni
authors.forename: Giovanni
authors.initials: G
authors.lastname: Principato
mesh_terms: D006801:Humans; D047468:Immunoprecipitation; D001523:Mental Disorders / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012326:RNA Splicing