title: [Research on the relationship of IgE between adenoid and middle ear effusion in children otitis media with effusion cases].
abstract: OBJECTIVE
  To study the expression of IgE in recur repeatedly children otitis media with effusion (OME), and the relativity of IgE between adenoid and middle ear effusion.
  
  
  METHODS
  Thirty-five cases diagnosed of OME in our department, were enrolled in the research. Thirty-one adenoidal hypertrophy cases were selected as control group. Obtained middle ear effusion and adenoid samples from experimental group, and obtained adenoid samples from control group. All adenoid samples were taken for tissue homogenate. Determination all samples of concentration of IgE by ELISA. SPSS 18.0 statistical software was used for all relevant data processing and analysis.
  
  
  RESULTS
  Compared the IgE content between experimental group and control group with adenoid samples, IgE content increased significantly in experimental group (P < 0.05), and IgE in experimental group of middle ear effusion samples were also increased (P < 0.05). The content of IgE in the experimental group of middle ear effusion and adenoid assumed straight-line correlation, in negative correlation (r = 0.580, P < 0.05).
  
  
  CONCLUSIONS
  The occurrence of OME is related to immune factors. Adenoidal hypertrophy may lead to local immunity enhancement, may cause middle ear cavity immune system abnormality, give rise to recur repeatedly with OME and procrastinate does not recover.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, the First Affiliated Hospital of Hunan Normal University, Changsha, 410005, China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Feng
authors.forename: Haihua
authors.initials: H
authors.lastname: Deng
authors.forename: Jihua
authors.initials: J
authors.lastname: Wang
authors.forename: Xuping
authors.initials: X
authors.lastname: Xiao
mesh_terms: D000234:Adenoids / Q000276:immunology / Q000378:metabolism*; D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004432:Ear, Middle / Q000276:immunology / Q000378:metabolism*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000378:metabolism*; D008297:Male; D010034:Otitis Media with Effusion / Q000276:immunology / Q000378:metabolism*
chemical_list: D007073:Immunoglobulin E