title: Comparison of health state utility values derived using time trade-off, rank and discrete choice data anchored on the full health-dead scale.
abstract: Recent years have seen increasing interest in the use of ordinal methods to elicit health state utility values as an alternative to conventional methods such as standard gamble and time trade-off (TTO). However, in order to use these ordinal methods to produce health state values for use in cost-effectiveness analysis using cost per quality adjusted life year (QALY) analysis, these values must be anchored on the full health-dead scale. The paper reports on two feasibility studies that use two approaches to anchor health state utility values derived from discrete choice data on the full health-dead scale: normalising using (1) the TTO value of the worst state and (2) the coefficient on the 'dead' dummy variable. Health state utility values obtained using rank and discrete choice data are compared to more commonly used TTO utility values for two condition-specific preference-based measures; asthma and overactive bladder. Ordinal methods were found to offer a promising alternative to conventional cardinal methods of standard gamble and TTO. There remains a large and important research agenda to address.
authors.affiliation: Health Economics and Decision Science, School of Health and Related Research (ScHARR), University of Sheffield, Regent Court, 30 Regent Street, Sheffield, S1 4DA, UK.
authors.forename: John
authors.initials: J
authors.lastname: Brazier
authors.forename: Donna
authors.initials: D
authors.lastname: Rowen
authors.forename: Yaling
authors.initials: Y
authors.lastname: Yang
authors.forename: Aki
authors.initials: A
authors.lastname: Tsuchiya
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D019057:Quality-Adjusted Life Years; D011795:Surveys and Questionnaires; D013997:Time Factors; D055815:Young Adult