title: Prognostic value of OCT4 in primary intracranial germinoma: a single institute analysis of 31 cases.
abstract: OCT4 expresses variably in primary intracranial germinomas. In this study, we tested our hypothesis that such variation of OCT4 is predictive of outcome in primary intracranial germinomas. Thirty-one histologically identified CNS germinoma patients were enrolled in our study. We collected medical data, immunohistochemically evaluated the OCT4 expression level, and followed up all patients from April 2001 to May 2010. We found that 7 of the 31 patients expressed OCT4 weakly, 11 expressed OCT4 moderately, and 13 expressed OCT4 strongly. No significant correlation between the OCT4 expression level and clinicopathological characteristics was observed. WV-CS combined treatment modality showed a better 5-year progression-free survival (PFS) rate than other treatment modalities and a low expression level of OCT4 showed a significantly better 5-year PFS. In both the WV-CS combined treatment modality and other treatments modality group, patients received a better 5-year PFS and had a lower level of OCT4 expression. As a result, we suggest OCT4 as a probable prognostic marker for intracranial germinoma.
authors.affiliation: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, PR China.
authors.forename: Siyi
authors.initials: S
authors.lastname: Wanggou
authors.forename: Xingjun
authors.initials: X
authors.lastname: Jiang
authors.forename: Xianrui
authors.initials: X
authors.lastname: Yuan
authors.forename: Caiping
authors.initials: C
authors.lastname: Ren
authors.forename: Ying
authors.initials: Y
authors.lastname: Zeng
authors.forename: Guifei
authors.initials: G
authors.lastname: Li
authors.forename: Qiaoyu
authors.initials: Q
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001932:Brain Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000628:therapy; D002648:Child; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D018237:Germinoma / Q000378:metabolism* / Q000401:mortality / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008279:Magnetic Resonance Imaging; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000401:mortality; D050814:Octamer Transcription Factor-3 / Q000378:metabolism*; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D050814:Octamer Transcription Factor-3; C494173:POU5F1 protein, human