title: [Prepulse inhibition of the startle response/reflex in neuropsychiatric disorders].
abstract: BACKGROUND
  Prepulse inhibition (PPI) of startle is an operational measure of the pre-attentive filtering process known as sensorimotor gating. PPI occurs when a relatively weak sensory event (the prepulse) is presented 30-500 ms before a strong startle inducing stimulus, and reduces the magnitude of the startle response. This experimental paradigm has been studied in laboratory animal as well as in patients with schizophrenia. Recently, PPI deficits have been observed in other psychiatric disorders that shared some deficit in cognitive and sensorimotor gating.
  
  
  METHODS
  We have reviewed studies examining prepulse inhibition in humans across some neuropsychiatric disorders for asses the clinical and neurobiological implications of this paradigm.
  
  
  CONCLUSIONS
  PPI deficits have been observed in multiple psychiatric disorders many of which present a common correlate anatomic-functional and a dysfunction in several neurotransmission systems, mainly dopamine system. These dysfunctions are independent of categorical diagnostic and they have proposed as a biological marker of vulnerability for some psychiatric disorders.
authors.affiliation: Servicio de Psiquiatría, Hospital Universitario de Móstoles, Móstoles (Madrid), España. fergarsan@gmail.com
authors.forename: Fernando
authors.initials: F
authors.lastname: García-Sánchez
authors.forename: Isabel
authors.initials: I
authors.lastname: Martínez-Gras
authors.forename: Roberto
authors.initials: R
authors.lastname: Rodríguez-Jiménez
authors.forename: Gabriel
authors.initials: G
authors.lastname: Rubio
mesh_terms: D000818:Animals; D015415:Biomarkers; D006801:Humans; D001523:Mental Disorders / Q000503:physiopathology*; D009422:Nervous System Diseases / Q000503:physiopathology*; D009433:Neural Inhibition / Q000502:physiology*; D013216:Reflex, Startle / Q000502:physiology*; D012559:Schizophrenia / Q000503:physiopathology; D055139:Sensory Gating / Q000502:physiology*
chemical_list: D015415:Biomarkers