title: Partial sequence of Mongolian gerbil (Meriones unguiculatus) immunoglobulin gamma heavy chain constant region.
abstract: We determined the sequence of the immunoglobulin gamma heavy-chain constant (IGHC) region of the Mongolian gerbil (Meriones unguiculatus). To isolate a part of the IGHC complementary DNA, we designed primers on the basis of highly conserved sequences in mouse, rat and hamster. The deduced IGHC is structurally similar to counterparts in other mammalian species and shows 84.6% identity to the IGHC of hamster IgG, 76.6% to rat IgG1, 83.3% to rat IgG2a, 78.1% to mouse IgG1, 81.8% to mouse IgG2a, 79.1% to mouse IgG2b and 79.2% to mouse IgG3 at the nucleotide level. The results suggest that gerbil IgG is closely related to hamster IgG and rat IgG2a.
authors.affiliation: College of Bioresource Sciences, Nihon University, Fujisawa, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Ukaji
authors.forename: Daisuke
authors.initials: D
authors.lastname: Sumiyama
authors.forename: Osamu
authors.initials: O
authors.lastname: Kai
mesh_terms: D000818:Animals; D001483:Base Sequence; D006224:Cricetinae; D018076:DNA, Complementary / Q000235:genetics*; D005849:Gerbillinae / Q000235:genetics*; D007127:Immunoglobulin Constant Regions / Q000235:genetics*; D007074:Immunoglobulin G / Q000235:genetics*; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D009841:Oligonucleotides; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D051381:Rats; D017422:Sequence Analysis, DNA
chemical_list: D018076:DNA, Complementary; D007127:Immunoglobulin Constant Regions; D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains; D009841:Oligonucleotides