title: Decursin, an active compound isolated from Angelica gigas, inhibits fat accumulation, reduces adipocytokine secretion and improves glucose tolerance in mice fed a high-fat diet.
abstract: Decursin (De), an active component of Angelica gigas, is known to exert anticancer and neuroprotective effects. However, its antiobesity and antidiabetic potential has not yet been investigated. This study evaluated the antiobesity effect of decursin, particularly focusing on its ability to inhibit adipocyte differentiation in 3T3-L1 cells. Decursin treatment resulted in the inhibition of adipocyte differentiation and the expression of fatty acid synthase. The study further investigated these antiobesity effects using mice fed a normal diet (ND), a high-fat diet (HFD) and a HFD plus decursin 200 mg/kg diet (HFD + De) for 7 weeks. Mice administered HFD plus decursin showed a drastic decrease in weight gain, triglyceride content, total cholesterol content and fat size compared with those that received the HFD alone; this was observed despite similar quantities of total food intake. Furthermore, decursin improved glucose tolerance in mice fed a HFD. Finally, administration of decursin along with the HFD significantly reduced the secretion of HFD-induced adipocytokines such as leptin, resistin, IL-6 and MCP-1. These results suggest that decursin might be useful for the treatment of obesity and diabetes.
authors.affiliation: Department of Biogeron Food Technology, Korea Food Research Institute, Kyongki-do, Republic of Korea.
authors.forename: Jin-Taek
authors.initials: JT
authors.lastname: Hwang
authors.forename: Sung Hee
authors.initials: SH
authors.lastname: Kim
authors.forename: Haeng Jeon
authors.initials: HJ
authors.lastname: Hur
authors.forename: Hyun Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Jae Ho
authors.initials: JH
authors.lastname: Park
authors.forename: Mi Jeong
authors.initials: MJ
authors.lastname: Sung
authors.forename: Hye Jeong
authors.initials: HJ
authors.lastname: Yang
authors.forename: Shi Yong
authors.initials: SY
authors.lastname: Ryu
authors.forename: Young Sup
authors.initials: YS
authors.lastname: Kim
authors.forename: Mi Ran
authors.initials: MR
authors.lastname: Cha
authors.forename: Myung Sunny
authors.initials: MS
authors.lastname: Kim
authors.forename: Dae Young
authors.initials: DY
authors.lastname: Kwon
mesh_terms: D041721:3T3-L1 Cells; D054392:Adipokines / Q000037:antagonists & inhibitors / Q000097:blood* / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism*; D029969:Angelica / Q000737:chemistry*; D000818:Animals; D019440:Anti-Obesity Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002087:Butyrates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002784:Cholesterol / Q000032:analysis; D059305:Diet, High-Fat / Q000009:adverse effects; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007333:Insulin Resistance; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000139:chemically induced / Q000503:physiopathology; D015430:Weight Gain / Q000187:drug effects
chemical_list: D054392:Adipokines; D019440:Anti-Obesity Agents; D001578:Benzopyrans; D001786:Blood Glucose; D002087:Butyrates; D007004:Hypoglycemic Agents; D002784:Cholesterol; C101278:decursin