title: [Probable association between preeclampsia/eclampsia and paternal age: a pilot study].
abstract: BACKGROUND
  The preeclampsia is a multisystemic syndrome that occupied the first cause of maternal and fetal mortality around the world. Epidemiologic studies shown both mother and father contribute at the same risk for preeclampsia.
  
  
  OBJECTIVE
  To determinate if there is an association between preeclampsia and paternal age.
  
  
  METHODS
  Preeclampsia-eclampsia patients and couples were analyzed in agree to "National High Blood Pressure Education Program Working Group" classification, and a control group constituted by normal pregnant women and couples was included.
  
  
  RESULTS
  There were 27 cases with mild preeclampsia and her couples, 13 cases with severe preeclampsia and her couples and 40 controls conformed by normal pregnant women and her couples. The statistical analysis of variance of the ages shown that men from preeclamptic group had a greater variance in contrast with man of control group (p < 0.001; valor of F = 5.084).
  
  
  CONCLUSIONS
  Although is not clear how paternal age interview in preeclampsia risk, the interaction between paternal-maternal imprinting and spermatic senescence, followed by shortened telomeres of chromosome, could be produce the inactivity of a whole network of signals implicated in disease aetiology.
authors.affiliation: Laboratorio de Medicina Genómica, Centro Médico Nacional 20 de Noviembre, ISSSTE, México. garortiz@yahoo.com
authors.forename: Liliana
authors.initials: L
authors.lastname: García-Ortiz
authors.forename: José
authors.initials: J
authors.lastname: Gutiérrez-Salinas
authors.forename: Carlos
authors.initials: C
authors.lastname: Galaviz-Hernández
authors.forename: María del Carmen
authors.initials: Mdel C
authors.lastname: Chima-Galán
authors.forename: José M
authors.initials: JM
authors.lastname: Hilton-Cáceres
authors.forename: Fernando
authors.initials: F
authors.lastname: Escobedo-Aguirre
authors.forename: Marlene
authors.initials: M
authors.lastname: de la Peña-Gutiérrez
authors.forename: Antonio
authors.initials: A
authors.lastname: Iniesta-Mejía
authors.forename: Juan
authors.initials: J
authors.lastname: Miranda-Murillo
mesh_terms: D000328:Adult; D015984:Causality; D003920:Diabetes Mellitus / Q000235:genetics; D004461:Eclampsia / Q000453:epidemiology*; D005260:Female; D018392:Genomic Imprinting; D006801:Humans; D006973:Hypertension / Q000235:genetics; D008297:Male; D008423:Maternal Age; D008875:Middle Aged; D008954:Models, Biological; D010331:Paternal Age; D010865:Pilot Projects; D011225:Pre-Eclampsia / Q000453:epidemiology*; D011247:Pregnancy; D012306:Risk; D055815:Young Adult