title: Protective role of heme oxygenase-1 in Listeria monocytogenes-induced abortion.
abstract: It is well-known fact that various pathogens, including bacteria, virus, and protozoa, induce abortion in humans and animals. However the mechanisms of infectious abortion are little known. In this study, we demonstrated that Listeria monocytogenes infection in trophoblast giant cells decreased heme oxygenase (HO)-1 and B-cell lymphoma-extra large (Bcl-XL) expression, and that their overexpression inhibited cell death induced by the infection. Furthermore, HO-1 and Bcl-XL expression levels were also decreased by L. monocytogenes in pregnant mice. Treatment with cobalt protoporphyrin, which is known to induce HO-1, inhibited infectious abortion. Taken together, our study indicates that L. monocytogenes infection decreases HO-1 and Bcl-XL expression and induces cell death in placenta, leading to infectious abortion.
authors.affiliation: The United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Tachibana
authors.forename: Masanori
authors.initials: M
authors.lastname: Hashino
authors.forename: Takashi
authors.initials: T
authors.lastname: Nishida
authors.forename: Takashi
authors.initials: T
authors.lastname: Shimizu
authors.forename: Masahisa
authors.initials: M
authors.lastname: Watarai
mesh_terms: D000022:Abortion, Spontaneous / Q000201:enzymology / Q000382:microbiology* / Q000517:prevention & control*; D000818:Animals; D015153:Blotting, Western; D005260:Female; D005455:Fluorescent Antibody Technique; D051547:Heme Oxygenase-1 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D008089:Listeria monocytogenes / Q000201:enzymology / Q000472:pathogenicity*; D008088:Listeriosis / Q000150:complications*; D051379:Mice; D008807:Mice, Inbred BALB C; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000201:enzymology / Q000517:prevention & control*; D011270:Pregnancy, Animal; D011524:Protoporphyrins / Q000627:therapeutic use*; D034741:RNA, Small Interfering / Q000235:genetics; D014327:Trophoblasts / Q000166:cytology / Q000187:drug effects; D051020:bcl-X Protein / Q000378:metabolism
chemical_list: C494812:Bcl2l1 protein, mouse; D011524:Protoporphyrins; D034741:RNA, Small Interfering; D051020:bcl-X Protein; C007095:cobaltiprotoporphyrin; D051547:Heme Oxygenase-1