title: Bioavailability of β-cryptoxanthin in the presence of phytosterols: in vitro and in vivo studies.
abstract: Bioactive compounds are used in the design and development of new food products with potential health benefits, although little is known regarding their bioavailability and interactions. This study assessed the stability, in vitro bioaccessibility, and human bioavailability of β-cryptoxanthin from β-cryptoxanthin-rich drinks with and without added phytosterols developed for this purpose. The developed drinks showed no difference in the content of β-cryptoxanthin, and they were stable over 6 months. In vitro, hydrolysis of β-cryptoxanthin esters and the amount of free β-cryptoxanthin at duodenal and micellar phases were similar regardless of the presence of phytosterols. In the human study, the daily intake provoked significant increments of β-cryptoxanthin in serum regardless of the type of the drink. In conclusion, in vitro and in vivo human studies have shown that the bioavailability of β-cryptoxanthin is not significantly affected by the presence of phytosterols when they are simultaneously supplied in a drink.
authors.affiliation: Unidad de Vitaminas, Hospital Universitario Puerta de Hierro-Majadahonda, 28222 Madrid, Spain. fgranado.hpth@salud.madrid.org
authors.forename: Fernando
authors.initials: F
authors.lastname: Granado-Lorencio
authors.forename: Encarnación
authors.initials: E
authors.lastname: Donoso-Navarro
authors.forename: Luis Manuel
authors.initials: LM
authors.lastname: Sánchez-Siles
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Blanco-Navarro
authors.forename: Belen
authors.initials: B
authors.lastname: Pérez-Sacristán
mesh_terms: D001628:Beverages / Q000032:analysis*; D001682:Biological Availability; D065366:Cryptoxanthins; D004347:Drug Interactions; D006801:Humans; D008297:Male; D008875:Middle Aged; D010840:Phytosterols / Q000494:pharmacology*; D028223:Pinus / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D024341:Xanthophylls / Q000493:pharmacokinetics*
chemical_list: D065366:Cryptoxanthins; D010840:Phytosterols; D010936:Plant Extracts; D024341:Xanthophylls