title: [Mexican clinical practice guidelines of immunotherapy 2011].
abstract: BACKGROUND
  Several international guidelines on immunotherapy exist, but they only apply partially in Mexico. The Mexican guideline of immunotherapy dates from 1998.
  
  
  OBJECTIVE
  To establish clinical recommendations and suggestions for Allergy residents and specialists for skin testing and allergen immunotherapy based on evidence and Mexican expert opinion, according to the GRADE system.
  
  
  METHODS
  The guidelines were developed following the methodology of a guideline for clinical practice starting with the formulation of clinical questions, in the context of Mexican environmental conditions and morbidity, with the participation of allergists from all regions of the country. External validation was obtained. Its development followed three steps: 1. formulation of 24 clinical questions. 2. Search for consensus on the answers among members of the Regional chapters of both Mexican Colleges of Allergists (CMICA and COMPEDIA) during regional meetings. 3. Literature search for articles related to the questions and grading of its quality according to GRADE.
  
  
  RESULTS
  Based on the regional consensus, 116 articles and the safety, patient acceptance/ comfort and cost clinical recommendations and suggestions were developed on basic aspects of skin testing, subcutaneous and sublingual immunotherapy (patient preparation, vial preparation and application schedules) and the treatment of eventual adverse reactions.
  
  
  CONCLUSIONS
  A clinical guideline was developed respecting particular methodology, validated by CMICA and COMPEDIA for its implementation among Mexican allergists. Several aspects deserve further study to improve scientific evidence.
  
  
  BACKGROUND
  Allergen immunotherapy, subcutaneous immunotherapy, sublingual immunotherapy, skin testing, allergy diagnosis, rhinitis, asthma, atopic dermatitis, house dust mite, pollens, anaphylaxis, adrenaline, Mexico.
authors.affiliation: Servicio de Asma y Alergia, Hospital Médica Sur. México DF.
authors.forename: Désirée
authors.initials: D
authors.lastname: Larenas-Linnemann
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Ortega-Martell
authors.forename: Blanca
authors.initials: B
authors.lastname: Del Río-Navarro
authors.forename: Noel
authors.initials: N
authors.lastname: Rodríguez-Pérez
authors.forename: Alfredo
authors.initials: A
authors.lastname: Arias-Cruz
authors.forename: Alan
authors.initials: A
authors.lastname: Estrada
authors.forename: Martín
authors.initials: M
authors.lastname: Becerril-Ángeles
authors.forename: Dino R
authors.initials: DR
authors.lastname: Pietropaolo-Cienfuegos
authors.forename: Maria de Jesús
authors.initials: Mde J
authors.lastname: Ambriz-Moreno
authors.forename: Carlos
authors.initials: C
authors.lastname: Báez-Loyola
authors.forename: Enna
authors.initials: E
authors.lastname: Cossío-Ochoa
authors.forename: Sandra Nora
authors.initials: SN
authors.lastname: González-Díaz
authors.forename: Emilia María
authors.initials: EM
authors.lastname: Hidalgo-Castro
authors.forename: Rosa Elena
authors.initials: RE
authors.lastname: Huerta-Hernández
authors.forename: Alejandra
authors.initials: A
authors.lastname: Macías-Weinmann
authors.forename: Joel
authors.initials: J
authors.lastname: Oyoqui-Flores
authors.forename: Héctor
authors.initials: H
authors.lastname: Stone-Aguilar
authors.forename: Marisol Belinda
authors.initials: MB
authors.lastname: Treviño-Salinas
authors.forename: María Del Carmen
authors.initials: Mdel C
authors.lastname: Zárate-Hernández
mesh_terms: D000485:Allergens / Q000627:therapeutic use; D000818:Animals; D001249:Asthma / Q000628:therapy; D003888:Desensitization, Immunologic; D006801:Humans; D006967:Hypersensitivity; D039981:Pyroglyphidae / Q000276:immunology; D012882:Skin Tests; D063729:Sublingual Immunotherapy
chemical_list: D000485:Allergens