title: Hypolipidemic and anti-inflammatory properties of Abacopterin A from Abacopteris penangiana in high-fat diet-induced hyperlipidemia mice.
abstract: This study was to investigate the hypolipidemic and anti-inflammatory properties of Abacopterin A (APA), a flavonoid compound isolated from Abacopteris penangiana (Hook.) Ching. Male C57BL/6J mice were divided randomly and equally into five groups: the normal control group (N), the model group (M), the positive control group (P), the high and low doses of APA treated groups (H and L). All the animals except that in N group were fed with high-fat diet for 8 weeks. In the last 4 weeks, the mice in P, H and L groups were orally administered with simvastatin (at the dose of 20mg/kg/day) and APA (at the dose of 40 or 20mg/kg/day), respectively. Then the lipid profiles and related biochemical criterions of the studied mice were determined. The effects of high-fat diet on activating nuclear transcription factor-κB (NFκB) expression, elevating inflammatory factors tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) levels, and increasing triacylglycerol (TG) and total cholesterol (TC) levels were abolished on daily supplementation with APA. APA also enhanced lipoprotein lipase (LPL) and hepatic lipase (HL) activities. These results suggested that APA had hypolipidemic and anti-inflammatory properties through inhibiting NFκB expression, and reducing inflammatory response.
authors.affiliation: Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation of Hubei Province, College of Pharmacy, Tongji Medical Center, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan 430030, PR China.
authors.forename: Yong-Fang
authors.initials: YF
authors.lastname: Lei
authors.forename: Jing-Lou
authors.initials: JL
authors.lastname: Chen
authors.forename: Han
authors.initials: H
authors.lastname: Wei
authors.forename: Chao-Mei
authors.initials: CM
authors.lastname: Xiong
authors.forename: Yong-Hui
authors.initials: YH
authors.lastname: Zhang
authors.forename: Jin-Lan
authors.initials: JL
authors.lastname: Ruan
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood; D059305:Diet, High-Fat; D004041:Dietary Fats / Q000008:administration & dosage; D029624:Ferns / Q000737:chemistry; D005786:Gene Expression Regulation; D006027:Glycosides / Q000494:pharmacology*; D006949:Hyperlipidemias / Q000139:chemically induced / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D015850:Interleukin-6 / Q000097:blood; D008071:Lipoprotein Lipase / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D000872:Anthocyanins; D000893:Anti-Inflammatory Agents; D004041:Dietary Fats; D006027:Glycosides; D000960:Hypolipidemic Agents; D015850:Interleukin-6; D016328:NF-kappa B; D010936:Plant Extracts; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; C570980:abacopterin A; D002784:Cholesterol; D008071:Lipoprotein Lipase