title: Pro-sexual effects of aqueous extracts of Massularia acuminata root in male Wistar rats.
abstract: Aqueous extract of Massularia acuminata root at the doses of 50, 100 and 200 mg kg(-1) body weight was investigated for its effect on sexual behaviour in male Wistar rats. Phytochemical screening revealed the presence of alkaloids, anthraquinones, saponins, phenolics, flavonoids and tannins in the extract. The increased (P < 0.05) frequencies of mount and intromission, computed male sexual behaviour parameters and significantly prolonged ejaculatory latency by the 50 and 100 mg kg(-1) body weight of the extract compared favourably (P > 0.05) with the reference drug, sildenafil citrate (Viagra). The extract also decreased the mount latency. The intromission latency at all the doses of the extract compared favourably with the distilled water-treated animals. The concentrations of serum testosterone, luteinising and follicle stimulating hormones increased at all the doses. All these are indications of prosexual effects of the extract, mediated by changes in the hormonal levels, brought about possibly by alkaloids, saponins and/or flavonoids. Overall, the present study supported the acclaimed use of M. acuminata root as an aphrodisiac in Yorubic medicine of Nigeria. Therefore, the aqueous extract of M. acuminata roots at 50 and 100 mg kg(-1) body weight may be explored in the management of disorders of desire, premature ejaculation and erectile dysfunction in males.
authors.affiliation: Phytomedicine, Toxicology, Reproductive and Developmental Biochemistry Research Laboratory, Department of Biochemistry, University of Ilorin, Nigeria. tomuyak@yahoo.com
authors.forename: M T
authors.initials: MT
authors.lastname: Yakubu
authors.forename: O S
authors.initials: OS
authors.lastname: Awotunde
authors.forename: T O
authors.initials: TO
authors.lastname: Ajiboye
authors.forename: A T
authors.initials: AT
authors.lastname: Oladiji
authors.forename: M A
authors.initials: MA
authors.lastname: Akanji
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012726:Sexual Behavior, Animal / Q000187:drug effects*
chemical_list: D010936:Plant Extracts