title: The potential role of RTN3 in monocyte recruitment and atherosclerosis.
abstract: The recruitment of monocytes to arterial wall and their transformation into macrophages are generally accepted as important early events in the pathogenesis of atherosclerosis (AS). Our research group found Reticulon3 (RTN3), a member of the reticulon family, may be a candidate pathogenic element in the progress of AS. But it is virtually unknown in which process RTN3 may participate in and regulate the pathogenesis of AS. Here, we hypothesis that RTN3 may participate in the continuous process of circulating monocyte recruitment in AS including: (1) monocyte spreading and adhesion to luminal endothelium; (2) transendothelial migration and may also contribute to the conversion of monocyte to macrophage in subendothelium.
authors.affiliation: Department of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China.
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Chen
authors.forename: Rong
authors.initials: R
authors.lastname: Xiang
authors.forename: Shuiping
authors.initials: S
authors.lastname: Zhao
mesh_terms: D050197:Atherosclerosis / Q000097:blood / Q000378:metabolism / Q000473:pathology*; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D002352:Carrier Proteins / Q000097:blood / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002454:Cell Differentiation; D003324:Coronary Artery Disease / Q000097:blood; D006801:Humans; D008565:Membrane Proteins / Q000097:blood / Q000378:metabolism*; D009000:Monocytes / Q000378:metabolism / Q000473:pathology*; D009419:Nerve Tissue Proteins / Q000097:blood / Q000378:metabolism*; D011485:Protein Binding; D057705:Transendothelial and Transepithelial Migration
chemical_list: D015415:Biomarkers; D002352:Carrier Proteins; D015815:Cell Adhesion Molecules; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C476198:RTN3 protein, human