title: Regio- and chemoselective metalation of arenes and heteroarenes using hindered metal amide bases.
abstract: The preparation of highly functionalized organometallic compounds can be achieved by direct C-H activation of a broad range of unsaturated substrates using lithium chloride solubilized 2,2,6,6-tetramethylpiperidide bases (TMP(n)MX(m)⋅p LiCl). These are excellent reagents for converting a wide range of aromatic and heterocyclic substrates into valuable organometallic reagents with broad applications in organic synthesis.
authors.affiliation: Department Chemie, Ludwig-Maximilians-Universität München, Germany.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Haag
authors.forename: Marc
authors.initials: M
authors.lastname: Mosrin
authors.forename: Hiriyakkanavar
authors.initials: H
authors.lastname: Ila
authors.forename: Vladimir
authors.initials: V
authors.lastname: Malakhov
authors.forename: Paul
authors.initials: P
authors.lastname: Knochel
mesh_terms: D000577:Amides / Q000737:chemistry*; D018021:Lithium Chloride / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D010880:Piperidines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000577:Amides; D009942:Organometallic Compounds; D010880:Piperidines; C551336:2,2,6,6-tetramethylpiperidide; D018021:Lithium Chloride