title: Efficacy of a novel rosacea treatment system: an investigator-blind, randomized, parallel-group study.
abstract: BACKGROUND
  A rosacea treatment system (cleanser, metronidazole 0.75% gel, hydrating complexion corrector, and sunscreen SPF30) has been developed to treat rosacea.
  
  
  METHODS
  Thirty women with mild or moderate erythema of rosacea on their facial cheeks were randomly assigned to use one of the following for 28 days: the rosacea treatment system (RTS); RTS minus metronidazole (RTS-M); or metronidazole 0.75% gel plus standard skin care (standard cleanser and standard moisturizer/sunscreen) (M+SSC).
  
  
  RESULTS
  At day 28, global improvement was evident in 90 percent of patients using RTS, 60 percent using RTS-M, and 67 percent using M+SSC. Erythema was significantly lower with RTS from day 14 onward, and unchanged with M+SSC. The proportion of patients reporting their skin was easily irritated at least sometimes was 40 percent with RTS, 70 percent with RTS-M, and 89 percent with M+SSC.
  
  
  CONCLUSIONS
  The rosacea treatment system may offer superior efficacy and tolerability to metronidazole plus the standard skin care used in this study.
authors.affiliation: KGL, Inc., Broomall, PA 19008, USA. jjleyden@mindspring.com
authors.forename: James J
authors.initials: JJ
authors.lastname: Leyden
mesh_terms: D000279:Administration, Cutaneous; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004890:Erythema / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D005260:Female; D005782:Gels; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D012393:Rosacea / Q000188:drug therapy* / Q000473:pathology; D016037:Single-Blind Method; D059405:Sun Protection Factor; D013473:Sunscreening Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; D005782:Gels; D013473:Sunscreening Agents; D008795:Metronidazole