title: Expression of complement regulatory proteins CD55, CD59, CD35, and CD46 in rheumatoid arthritis.
abstract: Rheumatoid arthritis (RA) is an autoimmune disease associated with polyarticular inflammatory synovitis affecting mainly peripheral joints. It affects approximately 1% of the world population, being two to three times more prevalent in women. Rheumatoid arthritis has a complex and multifactorial pathogenesis. The synovium of the affected joints is infiltrated by T and B lymphocytes, macrophages, and granulocytes. The rheumatoid synovium has proliferative characteristics, forming the pannus, which invades cartilage and bone, leading to normal architecture destruction and function loss. The decreased expression of complement regulatory proteins (CRP) seems to play an important role in RA activity, and is associated with worsening of the clinical symptoms. In several models of autoimmune diseases, the overactivation of the complement system (CS) is the cause of disease exacerbation. This article aimed at reviewing the main aspects related to CS regulation in RA in order to provide a better understanding of the potential role of this system in the pathophysiology and activity of the disease.
authors.affiliation: Universidade Federal do Rio Grande do Sul, Brasil.
authors.forename: Amanda Kirchner
authors.initials: AK
authors.lastname: Piccoli
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Alegretti
authors.forename: Laiana
authors.initials: L
authors.lastname: Schneider
authors.forename: Priscila Schmidt
authors.initials: PS
authors.lastname: Lora
authors.forename: Ricardo Machado
authors.initials: RM
authors.lastname: Xavier
mesh_terms: D001172:Arthritis, Rheumatoid / Q000276:immunology*; D018958:CD55 Antigens / Q000096:biosynthesis*; D018957:CD59 Antigens / Q000096:biosynthesis*; D006801:Humans; D051916:Membrane Cofactor Protein / Q000096:biosynthesis*; D017463:Receptors, Complement 3b / Q000096:biosynthesis*
chemical_list: C497857:CD46 protein, human; D018958:CD55 Antigens; D018957:CD59 Antigens; C509991:CR1 protein, human; D051916:Membrane Cofactor Protein; D017463:Receptors, Complement 3b; C051590:CD59 protein, human