title: Dendritic cell neurofibroma sine pseudorosettes: report of a case with a granulomatous appearance.
abstract: An unusual variant of dendritic cell neurofibroma is reported. In contrast to previous cases, the formation of pseudorosettes was lacking. The tumor was located on the anterior aspect of the thigh in a previously healthy 71-year-old woman with no evidence of neurofibromatosis. The tumor was composed of type-1 and type-2 cells, which were immunoreactive for S-100 protein and CD57. The granulomatous appearance was due to the zonal accumulation of CD34-positive dendritic cells and type-1 cells in a serpiginous fashion surrounding large areas with lesser cellularity featuring type-2 cells with scattered type-1 cells arranged in a haphazard fashion. Intralesional small neurites positive for neurofilament and perilesional perineural cells positive for epithelial membrane antigen were documented immunohistochemically.
authors.affiliation: Department of Pathology, National University Hospital, Singapore. fredrikpetersson@live.se
authors.forename: Fredrik
authors.initials: F
authors.lastname: Petersson
mesh_terms: D000368:Aged; D003713:Dendritic Cells / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018317:Nerve Sheath Neoplasms / Q000378:metabolism / Q000473:pathology*; D009455:Neurofibroma / Q000378:metabolism / Q000473:pathology*