title: Fixation behavior in primary open angle glaucoma at early and moderate stage assessed by the MicroPerimeter MP-1.
abstract: OBJECTIVE
  Using MicroPerimetry MP-1 to assess the fixation behavior in early and moderate primary open angle glaucoma (POAG).
  
  
  METHODS
  Thirty-nine early and moderate POAG eyes and 22 normal eyes were enrolled prospectively. The stability and location of the fixation in each subject eye were recorded by the macula 10-degree program of the microperimeter (MP-1). Retinal sensitivity was examined using the G2 program phase 1 of an Octopus 101 perimeter and the macula 10-degree program of the MP-1. The fixation behavior and the retinal sensitivity were compared between POAG and control groups. The correlation between the fixation behavior and the retinal sensitivity was analyzed in POAG patients.
  
  
  RESULTS
  : Fixation instability was detected in POAG (P=0.016). It correlated with the mean defect on Octopus perimeter and all the mean macular sensitivity parameters of MP-1, which includes the central 10 degrees (r=0.416, P=0.008), 6 degrees (r=0.401, P=0.011), 2 degrees (r=0.376, P=0.018), inferotemporal (r=0.399, P=0.012) and inferonasal (r=0.387, P=0.015) quadrants of the central 6 degrees. All the POAG patients had a predominantly central fixation.
  
  
  CONCLUSIONS
  Fixation instability manifested in early and moderate POAG eyes, which may be an early sign of POAG.
authors.affiliation: Department of Ophthalmology, Peking University Third Hospital, Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Shi
authors.forename: Mugen
authors.initials: M
authors.lastname: Liu
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Chun
authors.initials: C
authors.lastname: Zhang
authors.forename: Ping
authors.initials: P
authors.lastname: Huang
mesh_terms: D003430:Cross-Sectional Studies; D005260:Female; D005403:Fixation, Ocular / Q000502:physiology*; D005902:Glaucoma, Open-Angle / Q000175:diagnosis / Q000503:physiopathology*; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012160:Retina / Q000503:physiopathology*; D014065:Tonometry, Ocular; D014792:Visual Acuity; D058609:Visual Field Tests / Q000379:methods*; D014794:Visual Fields / Q000502:physiology*