title: Stromal cell derived factor-1α enhances bone formation based on in situ recruitment: a histologic and histometric study in rabbit calvaria.
abstract: Histological methods were used to assess whether in situ recruitment using stromal cell derived factor-1α (SDF-1α) enhances bone formation. Four defects were created in the calvarias of 16 rabbits and filled with: (1) a blood clot only (group C); (2) autogenous bone particles (AB, 0.2 ml) (group AB); (3) AB (0.1 ml) + bone marrow derived stromal stem cells (group ABC); or (4) AB (0.1 ml) + SDF-1α (group ABS). Bone formation was significantly greater in groups AB and ABC compared with group ABS after 2 weeks (P < 0.05). Bone formation was similar between groups AB, ABC, and ABS after 4 weeks (P > 0.05). SDF-1α is a promising candidate for in situ recruitment in bone regeneration.
authors.affiliation: Department of Orthopedic Surgery, The First Affiliated Hospital, Harbin Medical University, 23Youzheng St, Nan Gang District, Harbin, 150001, People's Republic of China.
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Liu
authors.forename: Shifeng
authors.initials: S
authors.lastname: Zhou
authors.forename: Yanjing
authors.initials: Y
authors.lastname: Li
authors.forename: Jinglong
authors.initials: J
authors.lastname: Yan
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D054377:Chemokine CXCL12 / Q000378:metabolism*; D006651:Histocytochemistry; D010012:Osteogenesis / Q000187:drug effects*; D011817:Rabbits; D011859:Radiography; D012886:Skull / Q000000981:diagnostic imaging / Q000378:metabolism*
chemical_list: D054377:Chemokine CXCL12