title: Barrett's esophagus: progression to adenocarcinoma and markers.
abstract: The following on progression to adenocarcinoma and markers of Barrett's esophagus includes commentariess on the expression of claudin 4 in Barrett's adenocarcinoma; the role of acid and bile salts; the role of insulin-like growth factor; the value of reactive oxygen species; the importance of abnormal methylation; genetic alterations in stromal cells and genomic changes in the epithelial cells; the value of confocal laser endomicroscopy for the subsurface analysis of the mucosa; indications for statins as adjuvant chemotherapeutic agent; the sequence of molecular events in malignant progression in Barrett's mucosa; and the value of the macroscopic markers and of p53 mutations.
authors.affiliation: South West Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Dianchun
authors.initials: D
authors.lastname: Fang
authors.forename: Kiron M
authors.initials: KM
authors.lastname: Das
authors.forename: Weibiao
authors.initials: W
authors.lastname: Cao
authors.forename: Usha
authors.initials: U
authors.lastname: Malhotra
authors.forename: George
authors.initials: G
authors.lastname: Triadafilopoulos
authors.forename: Robert M
authors.initials: RM
authors.lastname: Najarian
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Hardie
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Lightdale
authors.forename: Ian L P
authors.initials: IL
authors.lastname: Beales
authors.forename: Valter Nilton
authors.initials: VN
authors.lastname: Felix
authors.forename: Paul M
authors.initials: PM
authors.lastname: Schneider
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Bellizzi
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D001471:Barrett Esophagus / Q000473:pathology*; D014408:Biomarkers, Tumor; D018450:Disease Progression; D004938:Esophageal Neoplasms / Q000473:pathology*; D006801:Humans; D019255:NADPH Oxidases / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D014408:Biomarkers, Tumor; D019255:NADPH Oxidases