title: Early postnatal changes of lipoprotein subclass profile in late preterm infants.
abstract: BACKGROUND
  Late preterm infants (LPIs; 34-37 gestational weeks at birth) have higher risk for several morbidities than do term infants (TIs). It has been suggested that a cholesterol and fatty acid supply may improve their outcomes. We investigated the lipoprotein subclass profile in LPIs to evaluate their early postnatal lipid metabolism.
  
  
  METHODS
  Eighty-one infants (25 LPIs, 56 TIs) were included. Cholesterol and triglyceride (TG) concentrations in 12 lipoprotein subclasses were measured at birth and at 1 month using HPLC.
  
  
  RESULTS
  In LPIs, the cord blood exhibited higher cholesterol concentrations in medium and large subclasses of very low-density lipoprotein (VLDL), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) compared to the values in TIs. During the first month of life, LPIs had greater increases in cholesterol concentrations of medium and large subclasses of VLDL than TIs, whereas postnatal increases in cholesterol concentrations of medium and large subclasses of LDL and HDL were smaller. TG concentrations were not different in each VLDL subclass at birth and at 1 month.
  
  
  CONCLUSIONS
  In LPIs, cord blood lipoprotein subclass profiles and the early postnatal change exhibited different, especially in cholesterol concentrations.
authors.affiliation: Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Nagano
authors.forename: Tomoo
authors.initials: T
authors.lastname: Okada
authors.forename: Ryuta
authors.initials: R
authors.lastname: Yonezawa
authors.forename: Kayo
authors.initials: K
authors.lastname: Yoshikawa
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Fujita
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Usukura
authors.forename: Masami
authors.initials: M
authors.lastname: Makimoto
authors.forename: Sigeharu
authors.initials: S
authors.lastname: Hosono
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Fujita
authors.forename: Shigeru
authors.initials: S
authors.lastname: Takahashi
authors.forename: Hideo
authors.initials: H
authors.lastname: Mugishima
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Yamamoto
mesh_terms: D002784:Cholesterol / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D014280:Triglycerides / Q000097:blood
chemical_list: D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol