title: An analytical approach to acceptance criteria for quality assurance of Intensity Modulated Radiotherapy.
abstract: Detectability and impact of potential treatment machine errors on IMRT treatments were evaluated. The ability of the gamma index to detect deliberately introduced errors was assessed and their clinical impact was assessed using Tumour Control Probability (TCP) and Normal Tissue Complication Probability. TCP was only marginally affected by 2mm errors in MLC position. Dose delivery errors had greater impact but were not detected as effectively using the gamma index. Acceptance criteria should include mean dose as well as gamma to help identify errors in the delivered dose.
authors.affiliation: Physics Department, Clatterbridge Centre for Oncology, Merseyside, UK. antony.john.carver@cern.ch
authors.forename: Antony
authors.initials: A
authors.lastname: Carver
authors.forename: Martyn
authors.initials: M
authors.lastname: Gilmore
authors.forename: Stephen
authors.initials: S
authors.lastname: Riley
authors.forename: Julien
authors.initials: J
authors.lastname: Uzan
authors.forename: Philip
authors.initials: P
authors.lastname: Mayles
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D019300:Medical Errors / Q000517:prevention & control; D011785:Quality Assurance, Health Care; D011829:Radiation Dosage; D011874:Radiometry / Q000592:standards; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D050397:Radiotherapy, Intensity-Modulated / Q000592:standards*; D012984:Software