title: Oxaliplatin scale and National Cancer Institute-Common Toxicity Criteria in the assessment of chemotherapy-induced peripheral neuropathy.
abstract: OBJECTIVE
  The aim of the study was to compare two different neurotoxicity scales in grading chemotherapy-induced neurotoxicity.
  
  
  METHODS
  The study sample consisted of 114 cancer patients who started chemotherapy with vinca alcaloids, platinum derivatives or taxanes. Neurotoxicity was evaluated with the National Cancer Institute-Common Toxicity Criteria (NCI-CTC) and oxaliplatin scales at baseline and after every third chemotherapy cycle thereafter.
  
  
  RESULTS
  Neuropathy was detected in 60%, 55% and 75% at the second, third and fourth visits, respectively, with the NCI-CTC sensory scale and 59%, 55% and 80% with the oxalipalatin scale. Of the patients with grade 3-4 toxicity on the oxaliplatin scale, 23/53 had grade 1, 18/53 had grade 2 and 12/53 had grade 3 neurotoxicity on the NCI-CTC sensory scale.
  
  
  CONCLUSIONS
  The oxaliplatin and NCI-CTC sensory scales were comparable in identifying chemotherapy-induced neuropathy, but the oxaliplatin scale more often detected the progression of the symptoms.
authors.affiliation: Department of Oncology, Helsinki University Central Hospital, P.O. Box 180, 00029 HUS, Helsinki, Finland.
authors.forename: Anna-Liisa
authors.initials: AL
authors.lastname: Kautio
authors.forename: Maija
authors.initials: M
authors.lastname: Haanpää
authors.forename: Hannu
authors.initials: H
authors.lastname: Kautiainen
authors.forename: Arto
authors.initials: A
authors.lastname: Leminen
authors.forename: Eija
authors.initials: E
authors.lastname: Kalso
authors.forename: Tiina
authors.initials: T
authors.lastname: Saarto
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D054547:National Cancer Institute (U.S.); D009944:Organoplatinum Compounds / Q000009:adverse effects*; D000077150:Oxaliplatin; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000175:diagnosis*; D014481:United States
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin