title: Durable molecular response despite F317L and E255K mutations: Successful treatment of chronic myeloid leukemia with sequential imatinib, nilotinib and dasatinib.
authors.forename: Tamara
authors.initials: T
authors.lastname: Intermesoli
authors.forename: Fausto
authors.initials: F
authors.lastname: Castagnetti
authors.forename: Simona
authors.initials: S
authors.lastname: Soverini
authors.forename: Adelaide
authors.initials: A
authors.lastname: Bussini
authors.forename: Orietta
authors.initials: O
authors.lastname: Spinelli
authors.forename: Alessandra
authors.initials: A
authors.lastname: Gnani
authors.forename: Renato
authors.initials: R
authors.lastname: Bassan
authors.forename: Gianantonio
authors.initials: G
authors.lastname: Rosti
mesh_terms: D000328:Adult; D019943:Amino Acid Substitution / Q000502:physiology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001549:Benzamides; D054316:Biomarkers, Pharmacological / Q000032:analysis* / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics / Q000378:metabolism; D000069439:Dasatinib; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D018698:Glutamic Acid / Q000235:genetics; D006801:Humans; D000068877:Imatinib Mesylate; D007930:Leucine / Q000235:genetics; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics; D008239:Lysine / Q000235:genetics; D020125:Mutation, Missense / Q000502:physiology; D010649:Phenylalanine / Q000235:genetics; D010879:Piperazines / Q000008:administration & dosage*; D020641:Polymorphism, Single Nucleotide / Q000502:physiology; D011743:Pyrimidines / Q000008:administration & dosage*; D012074:Remission Induction; D013844:Thiazoles / Q000008:administration & dosage*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D001549:Benzamides; D054316:Biomarkers, Pharmacological; D014408:Biomarkers, Tumor; D010879:Piperazines; D011743:Pyrimidines; D013844:Thiazoles; D018698:Glutamic Acid; D010649:Phenylalanine; D000068877:Imatinib Mesylate; D016044:Fusion Proteins, bcr-abl; C498826:nilotinib; D007930:Leucine; D008239:Lysine; D000069439:Dasatinib