title: Three-dimensional correlation of steric and electronic free energy relationships guides asymmetric propargylation.
abstract: Chemical reaction outcomes are often rationalized on the basis of independent analyses of steric and electronic effects. We applied three-dimensional free energy relationships correlating steric and electronic effects to design and optimize a ligand class for the enantioselective Nozaki-Hiyama-Kishi propargylation of ketones. The resultant mathematical model describing the steric and electronic parameter relationship is highly reliant on the synergistic interactions of these two effects.
authors.affiliation: Department of Chemistry, University of Utah, Salt Lake City, UT 84112, USA.
authors.forename: Kaid C
authors.initials: KC
authors.lastname: Harper
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Sigman