title: Development and validation of the Individual Burden of Illness Index for Major Depressive Disorder (IBI-D).
abstract: This study aims at developing a single numerical measure that represents a depressed patient's individual burden of illness. An exploratory study examined depressed outpatients (n = 317) followed by a hypothesis confirmatory study using the NIMH STAR*D trial (n = 2,967). Eigenvalues/eigenvectors were obtained from the Principal Component Analyses of patient-reported measures of symptom severity, functioning, and quality of life. The study shows that a single principal component labeled as the Individual Burden of Illness Index for Depression (IBI-D) accounts for the vast majority of the variance contained in these three measures providing a numerical z score for clinicians and investigators to determine an individual's burden of illness, relative to other depressed patients.
authors.affiliation: Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center and David Geffen School of Medicine at UCLA, 8730 Alden Drive, Los Angeles, CA 90048, USA. Waguih.Ishak@cshs.org
authors.forename: Waguih William
authors.initials: WW
authors.lastname: Ishak
authors.forename: Jared Matt
authors.initials: JM
authors.lastname: Greenberg
authors.forename: Tammy
authors.initials: T
authors.lastname: Saah
authors.forename: Shakiba
authors.initials: S
authors.lastname: Mobaraki
authors.forename: Hala
authors.initials: H
authors.lastname: Fakhry
authors.forename: Qian Vicky
authors.initials: QV
authors.lastname: Wu
authors.forename: Eunis
authors.initials: E
authors.lastname: Ngor
authors.forename: Fei
authors.initials: F
authors.lastname: Yu
authors.forename: Robert M
authors.initials: RM
authors.lastname: Cohen
mesh_terms: D000328:Adult; D017281:Cost of Illness; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D025341:Principal Component Analysis; D011594:Psychometrics / Q000295:instrumentation; D011788:Quality of Life / Q000523:psychology; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires