title: The acute effects of passive smoking on mean platelet volume in healthy volunteers.
abstract: Mean platelet volume (MPV) is an indicator of platelet activation. We investigated the acute effect of passive smoking on MPV in healthy volunteers. Healthy nonsmoker volunteers (n = 90) spent 120 minutes in a smoke-free room. Then they were exposed to passive smoking in 3 groups consisting of 30 volunteers each in group A (carbon monoxide [CO] < 7.5 ppm), group B (CO = 7.5-15 ppm), and group C (CO > 15 ppm) for 120 minutes in a smoking room. Mean platelet volume did not change in group A and in the smoke-free room. Mean platelet volume increased significantly at the 60th minute and continued to increase at the 90th and 120th minute in group B. Mean platelet volume increased significantly at the 30th minute and continued to increase at the 60th, 90th, and 120th minute in group C. In conclusion, acute exposure to passive smoking affected MPV according to the duration and intensity of smoke.
authors.affiliation: Department of Cardiology, Sorgun State Hospital, Yozgat, Turkey.
authors.forename: Mikail
authors.initials: M
authors.lastname: Yarlioglues
authors.forename: Idris
authors.initials: I
authors.lastname: Ardic
authors.forename: Orhan
authors.initials: O
authors.lastname: Dogdu
authors.forename: Mahmut
authors.initials: M
authors.lastname: Akpek
authors.forename: Cemil
authors.initials: C
authors.lastname: Zencir
authors.forename: Haci Ahmet
authors.initials: HA
authors.lastname: Kasapkara
authors.forename: Saban
authors.initials: S
authors.lastname: Kelesoglu
authors.forename: Deniz
authors.initials: D
authors.lastname: Elcik
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Ozdogru
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Oguzhan
authors.forename: Mehmet Gungor
authors.initials: MG
authors.lastname: Kaya
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000187:drug effects* / Q000473:pathology; D002248:Carbon Monoxide / Q000009:adverse effects*; D048429:Cell Size / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D015539:Platelet Activation / Q000187:drug effects; D010976:Platelet Count; D011446:Prospective Studies; D012906:Smoke / Q000009:adverse effects*; D013997:Time Factors; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*; D014421:Turkey; D055815:Young Adult
chemical_list: D012906:Smoke; D014028:Tobacco Smoke Pollution; D002248:Carbon Monoxide