title: Mupirocin resistance is not an inevitable consequence of mupirocin use.
abstract: The rate of mupirocin resistance in meticillin-resistant Staphylococcus aureus (MRSA) in Besançon University Hospital is low with a decreasing trend, from 10% in 2004 to 3% in 2009. This trend in resistance paralleled mupirocin consumption. Genotyping results showed that this decrease was not linked to a change in MRSA clones. It appears that the way in which the mupirocin is used, rather than the volume, plays a role in the emergence of resistance and that its cautious use is likely to maintain the mupirocin resistance at a low level, thus preserving its efficacy.
authors.affiliation: Service d'Hygiène Hospitalière Centre Hospitalier Universitaire Besançon, Besançon, France.
authors.forename: D
authors.initials: D
authors.lastname: Talon
authors.forename: C
authors.initials: C
authors.lastname: Marion
authors.forename: M
authors.initials: M
authors.lastname: Thouverez
authors.forename: X
authors.initials: X
authors.lastname: Bertrand
mesh_terms: D003428:Cross Infection / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D004363:Drug Utilization / Q000706:statistics & numerical data*; D005838:Genotype; D006761:Hospitals; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D058889:Molecular Typing; D016712:Mupirocin / Q000494:pharmacology* / Q000627:therapeutic use*; D013203:Staphylococcal Infections / Q000382:microbiology
chemical_list: D016712:Mupirocin