title: RNA-based gene therapy for the treatment and prevention of HIV: from bench to bedside.
abstract: Gene therapy is considered a feasible approach for the treatment and prevention of HIV/AIDS. Targeting both viral genes and host dependency factors can interfere with the viral lifecycle and prevent viral replication. A number of approaches have been taken to target these genes, including ribozymes, aptamers, and RNAi based therapies. A number of these therapies are now beginning to make their way into clinical trials and providing proof of principle that gene therapy is a safe and realistic option for treating HIV. Here, we focus on those therapies that have progressed along the pipeline to preclinical and clinical testing.
authors.affiliation: Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, Connecticut 06511, USA.
authors.forename: Skye J
authors.initials: SJ
authors.lastname: Zeller
authors.forename: Priti
authors.initials: P
authors.lastname: Kumar
mesh_terms: D019380:Anti-HIV Agents / Q000378:metabolism / Q000627:therapeutic use*; D018952:Antigens, CD34 / Q000378:metabolism; D023241:Antiretroviral Therapy, Highly Active; D052157:Aptamers, Nucleotide / Q000378:metabolism / Q000627:therapeutic use; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism; D002986:Clinical Trials as Topic; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors / Q000235:genetics / Q000378:metabolism; D006678:HIV / Q000472:pathogenicity / Q000502:physiology; D015658:HIV Infections / Q000517:prevention & control / Q000628:therapy* / Q000821:virology; D016325:HIV Long Terminal Repeat; D006801:Humans; D034622:RNA Interference; D016337:RNA, Catalytic / Q000378:metabolism / Q000627:therapeutic use; D034741:RNA, Small Interfering / Q000378:metabolism / Q000627:therapeutic use; D014779:Virus Replication
chemical_list: D019380:Anti-HIV Agents; D018952:Antigens, CD34; D052157:Aptamers, Nucleotide; D016337:RNA, Catalytic; D034741:RNA, Small Interfering; C418481:hairpin ribozyme