title: Copper(I) catalyzed regioselective asymmetric alkoxyamination of aryl enamide derivatives.
abstract: The copper(I) catalyzed reaction of an enamide with an iminoiodane, in the presence of an alcohol, triggers the direct alkoxyamination of the double bond. This transformation represents a straightforward access to α-amino aminals in a completely regio- and diastereoselective manner. Use of a chiral Box ligand allows this reaction to be carried out in an enantioselective fashion.
authors.affiliation: Institut de Chimie des Substances Naturelles, UPR 2301 CNRS, Avenue de la Terrasse, 91198 Gif-Sur-Yvette, France.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Nakanishi
authors.forename: Corinne
authors.initials: C
authors.lastname: Minard
authors.forename: Pascal
authors.initials: P
authors.lastname: Retailleau
authors.forename: Kevin
authors.initials: K
authors.lastname: Cariou
authors.forename: Robert H
authors.initials: RH
authors.lastname: Dodd
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000577:Amides / Q000737:chemistry*; D000586:Amination; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D000577:Amides; D008024:Ligands; C059688:alkoxyl radical; D003300:Copper