title: Role of osteoclasts and interleukin-17 in the pathogenesis of rheumatoid arthritis: crucial 'human osteoclastology'.
abstract: Many papers have reported that osteoclasts play an important role in the pathogenesis of rheumatoid arthritis (RA); however, when we started to investigate the pathogenesis of RA, the roles of osteoclasts were not highlighted in RA bone resorption. In recent years, the number of articles on the roles of osteoclasts and interleukin (IL)-17 in the pathogenesis of RA has increased exponentially. In this review article, we describe our articles on the roles of osteoclasts and IL-17 in joint destruction in RA, from 1990 to 2011, and highlight a novel term, 'human osteoclastology', which we have used since 2008.
authors.affiliation: Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-cho, Shinjuku-ku, Tokyo, 162-0054, Japan. skotake@ior.twmu.ac.jp
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kotake
authors.forename: Toru
authors.initials: T
authors.lastname: Yago
authors.forename: Manabu
authors.initials: M
authors.lastname: Kawamoto
authors.forename: Yuki
authors.initials: Y
authors.lastname: Nanke
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology* / Q000473:pathology; D001862:Bone Resorption / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D004195:Disease Models, Animal; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology*; D010010:Osteoclasts / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D020381:Interleukin-17