title: Rhythmic leptin is required for weight gain from circadian desynchronized feeding in the mouse.
abstract: The neuroendocrine and metabolic effects of leptin have been extensively researched since the discovery, and the later identification, of the leptin gene mutated within the ob/ob mouse. Leptin is required for optimal health in a number of physiological systems (e.g. fertility, bone density, body weight regulation). Despite the extensive leptin literature and many observations of leptin's cyclical pattern over the 24-hour day, few studies have specifically examined how the circadian rhythm of leptin may be essential to leptin signaling and health. Here we present data indicating that a rhythmic leptin profile (e.g. 1 peak every 24 hours) leads to excessive weight gain during desynchronized feeding whereas non-rhythmic leptin provided in a continuous manner does not lead to excessive body weight gain under similar feeding conditions. This study suggests that feeding time can interact with leptin's endogenous rhythm to influence metabolic signals, specifically leading to excessive body weight gains during 'wrongly' timed feeding.
authors.affiliation: Northwestern University, Center for Sleep and Circadian Biology, Evanston, Illinois, United States of America.
authors.forename: Deanna Marie
authors.initials: DM
authors.lastname: Arble
authors.forename: Martha Hotz
authors.initials: MH
authors.lastname: Vitaterna
authors.forename: Fred W
authors.initials: FW
authors.lastname: Turek
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D002940:Circadian Rhythm / Q000187:drug effects*; D005247:Feeding Behavior; D020738:Leptin / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008820:Mice, Obese; D009765:Obesity / Q000209:etiology*; D010507:Periodicity; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D020738:Leptin