title: Iridium-catalyzed asymmetric allylation of sodium triisopropylsilanethiolate: a new way to form chiral thiols.
abstract: The iridium phosphoramidite complex-promoted regio- and enantioselective reaction of allylic carbonates with sodium triisopropylsilanethiolate produced allylic sulfides in 40-77% yields with up to 97 : 3 (branched : linear) and 89% ee, which were readily transformed into chiral thiol in 68% yield with 87% ee or disulfides with two chiral C-S bond centers in 40-73% yields with up to 90 : 10 dr and 99% ee.
authors.affiliation: Department of Chemistry, Tongji University, Shanghai, 200092, P.R. China.
authors.forename: Weiqing
authors.initials: W
authors.lastname: Huang
authors.forename: Shengcai
authors.initials: S
authors.lastname: Zheng
authors.forename: Jialiang
authors.initials: J
authors.lastname: Tang
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Zhao