title: Interferon-beta, but not tumor necrosis factor-alpha, production in response to poly I:C is maintained despite exhaustive exercise in mice.
abstract: It remains unclear whether immune response to viral infection is inhibited by severe exercise. We determined whether exhaustive exercise inhibits interferon (IFN)-β and tumor necrosis factor (TNF)-α production after injection of synthetic double-stranded (ds) RNAs, a polyriboinosinic polyribocytidylic acid (poly I:C), as viral infection model. Male C3H/HeN mice, which were divided into exhaustive-exercised and non-exercised groups, were injected with poly I:C (5 mg/kg). Although TNF-α in response to poly I:C was significantly inhibited by exhaustive exercise, IFN-β was no different in both groups. In in-vitro experiments, catecholamines inhibited poly I:C-induced TNF-α, but not IFN-β, production in macrophages. These results suggest that anti-virus cytokine IFN-β in response to poly I:C might be maintained despite severe stressful exercise.
authors.affiliation: Department of Cytology and Histology, Okayama University Graduate School, Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Masataka
authors.initials: M
authors.lastname: Uchida
authors.forename: Eri
authors.initials: E
authors.lastname: Oyanagi
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Kremenik
authors.forename: Junzo
authors.initials: J
authors.lastname: Sasaki
authors.forename: Hiromi
authors.initials: H
authors.lastname: Yano
mesh_terms: D000818:Animals; D004298:Dopamine / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D016899:Interferon-beta / Q000096:biosynthesis*; D008264:Macrophages / Q000187:drug effects; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009638:Norepinephrine / Q000494:pharmacology; D005082:Physical Exertion / Q000502:physiology*; D011070:Poly I-C / Q000494:pharmacology*; D013312:Stress, Physiological / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
chemical_list: D014409:Tumor Necrosis Factor-alpha; D016899:Interferon-beta; D011070:Poly I-C; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine