title: A polymer nanostructured Fabry-Perot interferometer based biosensor.
abstract: A polymer nanostructured Fabry-Perot interferometer (FPI) based biosensor is reported. Different from a conventional FPI, the nanostructured FPI has a layer of Au-coated nanopores inside its cavity. The Au-coated nanostructure layer offers significant enhancement of optical transducing signals due to the localized surface plasmon resonance effect and also due to the significantly increased sensing surface area, which is up to at least two orders of magnitude larger than that of a conventional FPI-based biosensor. Using this technical platform, the immobilization of captures proteins (protein A) on the nanostructure layer and their binding with immunoglobulin G (IgG) has been monitored in real time, resulting in the shift of the interference fringes of the optical transducing signals. Current results show that the limit-of-detection of the biosensor should be lower than 10 pg/mL for IgG-protein A binding.
authors.affiliation: Institute for Micromanufacturing, Louisiana Tech University, Ruston, LA, USA.
authors.forename: Tianhua
authors.initials: T
authors.lastname: Zhang
authors.forename: Pushparaj
authors.initials: P
authors.lastname: Pathak
authors.forename: Sukrut
authors.initials: S
authors.lastname: Karandikar
authors.forename: Rebecca
authors.initials: R
authors.lastname: Giorno
authors.forename: Long
authors.initials: L
authors.lastname: Que
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007074:Immunoglobulin G / Q000032:analysis* / Q000737:chemistry; D007368:Interferometry / Q000295:instrumentation*; D049329:Nanostructures / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013205:Staphylococcal Protein A / Q000737:chemistry*
chemical_list: D007074:Immunoglobulin G; D011108:Polymers; D013205:Staphylococcal Protein A