title: Responsive neuromodulators based on artificial neural networks used to control seizure-like events in a computational model of epilepsy.
abstract: Deep brain stimulation (DBS) has been noted for its potential to suppress epileptic seizures. To date, DBS has achieved mixed results as a therapeutic approach to seizure control. Using a computational model, we demonstrate that high-complexity, biologically-inspired responsive neuromodulation is superior to periodic forms of neuromodulation (responsive and non-responsive) such as those implemented in DBS, as well as neuromodulation using random and random repetitive-interval stimulation. We configured radial basis function (RBF) networks to generate outputs modeling interictal time series recorded from rodent hippocampal slices that were perfused with low Mg²⁺/high K⁺ solution. We then compared the performance of RBF-based interictal modulation, periodic biphasic-pulse modulation, random modulation and random repetitive modulation on a cognitive rhythm generator (CRG) model of spontaneous seizure-like events (SLEs), testing efficacy of SLE control. A statistically significant improvement in SLE mitigation for the RBF interictal modulation case versus the periodic and random cases was observed, suggesting that the use of biologically-inspired neuromodulators may achieve better results for the purpose of electrical control of seizures in a clinical setting.
authors.affiliation: Edwards S. Rogers Sr. Department of Electrical and Computer Engineering, University of Toronto, Toronto, ON M5S3G4, Canada.
authors.forename: Sinisa
authors.initials: S
authors.lastname: Colic
authors.forename: Osbert C
authors.initials: OC
authors.lastname: Zalay
authors.forename: Berj L
authors.initials: BL
authors.lastname: Bardakjian
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D003198:Computer Simulation; D046690:Deep Brain Stimulation; D004827:Epilepsy / Q000503:physiopathology*; D006624:Hippocampus / Q000502:physiology / Q000503:physiopathology; D006801:Humans; D008274:Magnesium / Q000378:metabolism; D008297:Male; D016571:Neural Networks, Computer; D018377:Neurotransmitter Agents; D011188:Potassium / Q000378:metabolism; D012372:ROC Curve; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000503:physiopathology*
chemical_list: D018377:Neurotransmitter Agents; D008274:Magnesium; D011188:Potassium