title: [Related systemic reactions to allergen immunotherapy in Monterrey, Mexico].
abstract: BACKGROUND
  Patients who receive allergen immunotherapy (IT) have a potential risk of systemic reactions, however such reactions are rare when IT administered properly. The frequency of systemic reactions (SR) due to conventional IT is less than 1%.
  
  
  OBJECTIVE
  To determine the frequency of secondary SR to allergen IT, and to identify the possible factors involved in developing them.
  
  
  METHODS
  A retrospective descriptive study that included 2.319 patients who received 14.600 allergen immunotherapy injections during the period from May 1, 2001 to April 30, 2002.
  
  
  RESULTS
  Twelve patients had a SR (age 7 - 40 years), all of which occurred within the first 30 minutes after the IT. These were more frequent during the dose - increase phase (58%). The frequency of (RS) in relation to the number of injections was 1:1216, and regarding to the number of patients, 1:193. The clinical  manifestations included bronchospasm 83%, urticaria 67%, gastrointestinal symptoms and hypotension 8.3%. The 58% had anaphylaxis and pulmonary or dermatological symptoms only in 33% and 8.3% respectively. The possible factors involved in the onset of SR were: sensitivity identified by large skin reactions in skin test (PC) 83%, uncontrolled asthma 50%, application of allergens IT during high pollination season 42%, inadequate immunotherapy scheme monitoring 17%.
  
  
  CONCLUSIONS
  The frequency of SR in this group of patients was low as that reported in other publications.
authors.affiliation: Centro Regional de Alergia e Inmunología Clínica, Hospital Universitario Dr. José E. González, Universidad Autónoma de Nuevo León.
authors.forename: Sandra Nora
authors.initials: SN
authors.lastname: González-Díaz
authors.forename: Jorge Humberto
authors.initials: JH
authors.lastname: de la Rosa-López
authors.forename: Alfredo
authors.initials: A
authors.lastname: Arias-Cruz
authors.forename: Alejandra
authors.initials: A
authors.lastname: Macías-Weinmann
authors.forename: Dayanara
authors.initials: D
authors.lastname: Herrera-Castro
authors.forename: Pablo
authors.initials: P
authors.lastname: Rodríguez-Ortíz
authors.forename: Alejandro
authors.initials: A
authors.lastname: Rojas-Lozano
authors.forename: Diego De Jesús
authors.initials: Dde J
authors.lastname: García-Calderín
mesh_terms: D000485:Allergens; D000707:Anaphylaxis / Q000139:chemically induced; D003888:Desensitization, Immunologic; D006801:Humans; D008800:Mexico; D012189:Retrospective Studies
chemical_list: D000485:Allergens