title: Triclabendazole protects yeast and mammalian cells from oxidative stress: identification of a potential neuroprotective compound.
abstract: The Prestwick and NIH chemical libraries were screened for drugs that protect baker's yeast from sugar-induced cell death (SICD). SICD is triggered when stationary-phase yeast cells are transferred from spent rich medium into water with 2% glucose and no other nutrients. The rapid, apoptotic cell death occurs because reactive oxygen species (ROS) accumulate. We found that triclabendazole, which is used to treat liver flukes in cattle and man, partially protects against SICD. Characterization of triclabendazole revealed that it also protects yeast cells from death induced by the Parkinson's disease-related protein alpha-synuclein (α-syn), which is known to induce the accumulation of ROS.
authors.affiliation: Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA.
authors.forename: Yong Joo
authors.initials: YJ
authors.lastname: Lee
authors.forename: Elodie
authors.initials: E
authors.lastname: Burlet
authors.forename: Shaoxiao
authors.initials: S
authors.lastname: Wang
authors.forename: Baoshan
authors.initials: B
authors.lastname: Xu
authors.forename: Shile
authors.initials: S
authors.lastname: Huang
authors.forename: Floyd J
authors.initials: FJ
authors.lastname: Galiano
authors.forename: Stephan N
authors.initials: SN
authors.lastname: Witt
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000302:isolation & purification / Q000494:pharmacology*; D002417:Cattle; D002460:Cell Line; D006801:Humans; D018696:Neuroprotective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects*; D017382:Reactive Oxygen Species / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000187:drug effects*; D054852:Small Molecule Libraries; D000077682:Triclabendazole; D051844:alpha-Synuclein / Q000494:pharmacology
chemical_list: D001562:Benzimidazoles; D018696:Neuroprotective Agents; D017382:Reactive Oxygen Species; D054852:Small Molecule Libraries; D051844:alpha-Synuclein; D000077682:Triclabendazole