title: Comparison of optic disc topography in the cases with graves disease and healthy controls.
abstract: OBJECTIVE
  To compare the optic nerve head topographic parameters of the cases with Graves disease (GD), and the age and sex-matched control group, by using Heidelberg retinal tomography III.
  
  
  METHODS
  We evaluated both eyes of 65 patients with GD and 54 age and sex-matched controls. For statistical analysis, Mann-Whitney U test and independent sample t test were used. Statistical significance was set as P < 0.05.
  
  
  RESULTS
  The study group consisted of 22 male (33.8%) and 43 female (66.2%) GD cases with a mean age of 40.3 ± 11.9 years and the control group consisted of 26 male (48.1%) and 28 female (51.9%) healthy controls with a mean age of 36.9 ± 7.6 years. The differences between the age and sexes of the groups were not statistically significant (P = 0.07 and P = 0.11, respectively). The mean intraocular pressure of the study group was 14.6 ± 2.9 mm Hg (range, 8 to 20 mm Hg), whereas in the control group, it was 13.4 ± 2.1 mm Hg (range, 10 to 19 mm Hg). The difference between the intraocular pressures was statistically significant (P = 0.01). The mean retinal nerve fiber layer (RNFL) thickness (0.31 ± 0.08 mm) and the mean RNFL cross-sectional area (1.5 ± 0.43 mm) of the control group were greater than the mean RNFL thickness (0.25 ± 0.06 mm) and the mean RNFL cross-sectional area (1.30 ± 0.32 mm) of the study group (P = 0.02, P = 0.03 respectively).
  
  
  CONCLUSIONS
  This result suggests that patients with GD may have thinner RNFL than healthy controls.
authors.affiliation: Ulucanlar Eye Education and Research Hospital, Numune Education and Training Hospital, Ankara, Turkey. eminesentr@yahoo.com
authors.forename: Emine
authors.initials: E
authors.lastname: Sen
authors.forename: Dilek
authors.initials: D
authors.lastname: Berker
authors.forename: Ufuk
authors.initials: U
authors.lastname: Elgin
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Tutuncu
authors.forename: Faruk
authors.initials: F
authors.lastname: Ozturk
authors.forename: Serdar
authors.initials: S
authors.lastname: Guler
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006111:Graves Disease / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D014054:Tomography; D014065:Tonometry, Ocular; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult