title: Numerical modeling of anisotropic fiber bundle behavior in oxygenators.
abstract: Prediction of flow patterns through oxygenator fiber bundles can allow shape optimization so that efficient gas exchange occurs with minimal thrombus formation and hemolysis. Computational fluid dynamics (CFD) simulations can be used to predict three-dimensional flow velocities and flow distribution from spatially dependent variables and they allow estimations of erythrocyte residence time within the fiber bundle. This study builds upon previous work to develop an accurate numerical model for oxygenators, which would allow for accelerated iterations in oxygenator shape and diffuser plate design optimization. Hollow fiber flow channels were developed to permit experimental calculation of fluid permeability in two directions: main flow along the hollow fiber and perpendicular to the hollow fibers. Commercial software was used to develop three-dimensional CFD models of the experimental flow channels and an anisotropic porous media model for oxygenators from these experimental results. The oxygenator model was used to predict pressure loss throughout the device, visualize blood distribution within the fiber bundle, and estimate erythrocyte residence time within the bundle. Experimental flow channels measurements produced a streamwise permeability of 1.143e(-8) m(2) and transverse permeability of 2.385e(-9) m(2) . These permeabilities, coupled with previous work with volume porosity, were used to develop the numerical model of anisotropic behavior through porous fiber bundles, which indicated a more uniform flow field throughout the oxygenator. Incorporation of known anisotropic fiber bundle behavior in previous numerical models more accurately represents fluid behavior through an oxygenator fiber bundle. CFD coupled with experimental validation can produce a powerful tool for oxygenator design and development.
authors.affiliation: Department of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University, Aachen, Germany. bhavsar.sonya@gmail.com
authors.forename: Sonya S
authors.initials: SS
authors.lastname: Bhavsar
authors.forename: Thomas
authors.initials: T
authors.lastname: Schmitz-Rode
authors.forename: Ulrich
authors.initials: U
authors.lastname: Steinseifer
mesh_terms: D016880:Anisotropy; D003198:Computer Simulation; D004867:Equipment Design; D004912:Erythrocytes / Q000166:cytology; D018056:Hemorheology; D006801:Humans; D057446:Hydrodynamics; D008954:Models, Biological; D008956:Models, Chemical; D010107:Oxygenators, Membrane; D010539:Permeability; D016062:Porosity