title: Synthesis of lipids for development of multifunctional lipid-based drug-carriers.
abstract: A simple approach to synthesize phospholipids to modulate drug release and track lipid-based particulate drug-carriers is described. We synthesized two ether lipids, 1 1-O-hexadecyl-2-pentadenoyl-sn-glycerol-3-phosphocholine (C(31)PC) and 2 1-O-hexadecyl-2-pentadenoyl-sn-glycerol-3-phosphomethanol (C(31)PM), and examined their ability to alter enzymatically triggered release of 6-carboxyfluorescein from liposomes incubated in TRIS buffer or fetal bovine serum solutions. Further, we demonstrated that odd-chain lipids, for example, C(31)PC, could be identified in rat plasma without interference of endogenous lipids. This approach can be adapted to synthesize a variety of lipids for use in developing and optimizing multifunctional drug-carriers.
authors.affiliation: Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, 215 W. Green Street, Rm 220 Athens, GA 30602 2352, United States.
authors.forename: Guodong
authors.initials: G
authors.lastname: Zhu
authors.forename: Yahya
authors.initials: Y
authors.lastname: Alhamhoom
authors.forename: Brian S
authors.initials: BS
authors.lastname: Cummings
authors.forename: Robert D
authors.initials: RD
authors.lastname: Arnold
mesh_terms: D000818:Animals; D004337:Drug Carriers; D008055:Lipids / Q000138:chemical synthesis*; D013058:Mass Spectrometry; D051381:Rats
chemical_list: D004337:Drug Carriers; D008055:Lipids