title: Meningococcal purpura fulminans in children: I. Initial orthopedic management.
abstract: BACKGROUND
  Purpura fulminans is a rare and extremely severe infection, mostly due to Neisseria meningitidis frequently causing early orthopedic lesions. Few studies have reported on the initial surgical management of acute purpura fulminans. The aim of this study is to look at the predictive factors in orthopedic outcome in light of the initial surgical management in children surviving initial resuscitation.
  
  
  METHODS
  Nineteen patients referred to our institution between 1987 and 2005 were taken care of at the very beginning of the purpura fulminans. All cases were retrospectively reviewed so as to collect information on the total skin necrosis, vascular insufficiency, gangrene, and total duration of vasopressive treatment.
  
  
  RESULTS
  All patients had multiorgan failure; only one never developed any skin necrosis or ischemia. Eighteen patients lost tissue, leading to 22 skin grafts, including two total skin grafts. There was only one graft failure. Thirteen patients were concerned by an amputation, representing, in total, 54 fingers, 36 toes, two transmetatarsal, and ten transtibial below-knee amputations, with a mean delay of 4 weeks after onset of the disease. Necrosis seems to affect mainly the lower limbs, but there is no predictive factor that impacted on the orthopedic outcome. We did not perform any fasciotomy or compartment pressure measurement to avoid non-perfusion worsening; nonetheless, our outcome in this series is comparable to existing series in the literature. V.A.C.(®) therapy could be promising regarding the management of skin necrosis in this particular context. While suffering from general multiorgan failure, great care should be observed not to miss any additional osseous or articular infection, as some patients also develop local osteitis and osteomyelitis that are often not diagnosed.
  
  
  CONCLUSIONS
  We do not advocate very early surgery during the acute phase of purpura fulminans, as it does not change the orthopedic outcome in these children. By performing amputations and skin coverage some time after the acute phase, we obtained similar results to those found in the literature.
authors.affiliation: Département de Chirurgie et Orthopédie de l'Enfant, Unité de Chirurgie Orthopédique et Traumatologique de l'Enfant, Hôpital Jeanne de Flandre, Avenue Eugène Avinée, 59037 Lille Cedex, France.
authors.forename: E
authors.initials: E
authors.lastname: Nectoux
authors.forename: A
authors.initials: A
authors.lastname: Mezel
authors.forename: S
authors.initials: S
authors.lastname: Raux
authors.forename: D
authors.initials: D
authors.lastname: Fron
authors.forename: M
authors.initials: M
authors.lastname: Maillet
authors.forename: B
authors.initials: B
authors.lastname: Herbaux