title: [Neurodevelopment at one year of age [corrected] in preterm newborns with history of maternal chorioamnionitis].
abstract: BACKGROUND
  Recent clinical and epidemiological researches indicate that in preterm infants exposed to chorioamnionitis increases the risk of neurological disorders.
  
  
  OBJECTIVE
  To know the neurological development in prematures newborn whose mothers suffered chorioamnionitis during pregnancy and to compare them with newborns without chorioamnionitis.
  
  
  METHODS
  Is a prospective, comparative, cohort study, which included newborn infants with < 34 weeks of gestacional age and with weight < 1,500 g at birth, born in the Instituto Nacional de Perinatologia from August 1, 2005 to December 31, 2006. Two groups were divided (with and without antecedents of maternal chorioamnionitis), paired by weight and gestacional age, with complete neurological assessment at one year of age with the following instruments: Amiel Tison and Vojta assessment, audiological and prelanguage evaluations.
  
  
  RESULTS
  104 patients were included; 23 belonged to the group with chorioamnionitis, and 81 to the group without chorioamnionitis. With the Amiel Tison assessment at one year of age we found a major alteration risk in active tone of the exposed children to chorioamnionitis (RR: 3.73, CI 95%: 1.05-13.3). The exploration of Vojta at the year of age was abnormal in the children exposed (RR: 1.64, CI 95%: 1.06-2.53). There were no differences in: hearing assessment, prelanguage skills, electroencephalography, visual and auditory evoked potentials of brain steam.
  
  
  CONCLUSIONS
  In the exposed group to chorioamnionitis there were a major number of patients (56.5%) with neurological alterations versus the one without chorioamnionitis (29.6%, RR: 1.90, CI 95%: 1.16-3.11). Motor alterations were found with more frequency in this study.
authors.affiliation: Jefe del Departamento de Seguimiento Pediátrico, Instituto Nacional de Perinatología, Isidro Espinosa de los Reyes, México, DF.
authors.forename: René H
authors.initials: RH
authors.lastname: Barrera-Reyes
authors.forename: Hilda
authors.initials: H
authors.lastname: Ruiz-Macías
authors.forename: Enrique
authors.initials: E
authors.lastname: Segura-Cervantes
mesh_terms: D001724:Birth Weight; D001925:Brain Damage, Chronic / Q000453:epidemiology / Q000209:etiology; D002585:Cesarean Section; D002821:Chorioamnionitis; D002658:Developmental Disabilities / Q000453:epidemiology* / Q000209:etiology; D005071:Evoked Potentials; D005260:Female; D005865:Gestational Age; D006801:Humans; D006819:Hyaline Membrane Disease / Q000453:epidemiology / Q000209:etiology; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000453:epidemiology* / Q000209:etiology; D007804:Language Development; D008297:Male; D009069:Movement Disorders / Q000453:epidemiology / Q000209:etiology; D009422:Nervous System Diseases / Q000453:epidemiology* / Q000209:etiology; D009460:Neurologic Examination; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011446:Prospective Studies