title: Overview of electrophysiological characterization of neuronal nicotinic acetylcholine receptors.
abstract: Electrophysiology is one of the best tools to characterize ligand-gated channels such as neuronal nicotinic acetylcholine receptors. In this unit, the properties of these receptors are discussed along with approaches for how they can be characterized. Special emphasis is given to agonist and antagonist profiles as well as allosteric effectors that offer alternative possibilities in drug discovery.
authors.affiliation: Centre Médical Universitaire, Geneva, Switzerland.
authors.forename: Sonia
authors.initials: S
authors.lastname: Bertrand
authors.forename: Daniel
authors.initials: D
authors.lastname: Bertrand
mesh_terms: D000494:Allosteric Regulation; D000818:Animals; D006801:Humans; D009474:Neurons / Q000502:physiology*; D018722:Nicotinic Agonists / Q000494:pharmacology; D018733:Nicotinic Antagonists / Q000494:pharmacology; D018408:Patch-Clamp Techniques / Q000379:methods*; D011978:Receptors, Nicotinic / Q000502:physiology*
chemical_list: D018722:Nicotinic Agonists; D018733:Nicotinic Antagonists; D011978:Receptors, Nicotinic