title: The fetal cerebellum: development and common malformations.
abstract: The cerebellum undergoes a protracted development, making it particularly vulnerable to a broad spectrum of developmental events. Acquired destructive and hemorrhagic insults may also occur. The main steps of cerebellar development are reviewed. The normal imaging patterns of the cerebellum in prenatal ultrasound and magnetic resonance imaging (MRI) are described with emphasis on the limitations of these modalities. Because of confusion in the literature regarding the terminology used for cerebellar malformations, some terms (agenesis, hypoplasia, dysplasia, and atrophy) are clarified. Three main pathologic settings are considered and the main diagnoses that can be suggested are described: retrocerebellar fluid enlargement with normal or abnormal biometry (Dandy-Walker malformation, Blake pouch cyst, vermian agenesis), partially or globally decreased cerebellar biometry (cerebellar hypoplasia, agenesis, rhombencephalosynapsis, ischemic and/or hemorrhagic damage), partially or globally abnormal cerebellar echogenicity (ischemic and/or hemorrhagic damage, cerebellar dysplasia, capillary telangiectasia). The appropriate timing for performing MRI is also discussed.
authors.affiliation: Service de Radiologie, Hôpital d'Enfants Armand-Trousseau, Paris, France. catherine.garel@trs.aphp.fr
authors.forename: Catherine
authors.initials: C
authors.lastname: Garel
authors.forename: Catherine
authors.initials: C
authors.lastname: Fallet-Bianco
authors.forename: Laurent
authors.initials: L
authors.lastname: Guibaud
mesh_terms: D002531:Cerebellum / Q000002:abnormalities / Q000196:embryology / Q000473:pathology; D003952:Diagnostic Imaging; D005333:Fetus / Q000002:abnormalities*; D006801:Humans; D009421:Nervous System Malformations / Q000175:diagnosis; D009474:Neurons / Q000473:pathology; D011296:Prenatal Diagnosis / Q000379:methods