title: Dendritic cell dysfunction during primary HIV-1 infection.
abstract: Dendritic cells have critical roles for generating and fine-tuning adaptive immune responses and for regulating immune activity through cytokine secretion. In this study, we analyzed functional properties of dendritic cells in primary human immunodeficiency virus type 1 (HIV-1) infection. We found substantial disarray of the functional properties of myeloid and plasmacytoid dendritic cells in acute HIV-1 infection, which included defective antigen-presenting and cytokine secretion properties and was associated with a distinct surface expression profile of immunomodulatory dendritic cell receptors from the leukocyte immunoglobulin-like receptor family. These data indicate that key functional properties of dendritic cells are compromised during primary HIV-1 infection.
authors.affiliation: Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA.
authors.forename: Jinghe
authors.initials: J
authors.lastname: Huang
authors.forename: Yue
authors.initials: Y
authors.lastname: Yang
authors.forename: Maha
authors.initials: M
authors.lastname: Al-Mozaini
authors.forename: Patrick S
authors.initials: PS
authors.lastname: Burke
authors.forename: Jill
authors.initials: J
authors.lastname: Beamon
authors.forename: Mary F
authors.initials: MF
authors.lastname: Carrington
authors.forename: Katherine
authors.initials: K
authors.lastname: Seiss
authors.forename: Jennifer
authors.initials: J
authors.lastname: Rychert
authors.forename: Eric S
authors.initials: ES
authors.lastname: Rosenberg
authors.forename: Mathias
authors.initials: M
authors.lastname: Lichterfeld
authors.forename: Xu G
authors.initials: XG
authors.lastname: Yu
mesh_terms: D000328:Adult; D017951:Antigen Presentation; D003430:Cross-Sectional Studies; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D005260:Female; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D018664:Interleukin-12 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D014409:Tumor Necrosis Factor-alpha; D018664:Interleukin-12