title: Carvedilol for the treatment of benign prostatic hypertrophy in patients with heart failure?
abstract: Heart failure (HF) and benign prostatic hypertrophy (BPH) are two conditions that commonly coexist in men 60 years and older. Carvedilol is the only β-adrenergic blocker approved for HF that also has additional α1-adrenergic blockade. As α1-adrenergic blockers are used in the treatment of BPH, it is intuitive that carvediolol could improve BPH symptoms. We present a case where carvedilol was replaced with bisoprolol resulting in acute urinary retention. When carvediolol was reinstituted, the patient's symptoms of BPH resolved. Benign prostatic hypertrophy was later diagnosed by digital rectal exam. Six month after reinstituting the carvediolol, the patient remains free of his BPH symptoms. This case suggests that carvedilol may be considered for the management of HF with systolic dysfunction in patients with concomitant BPH thus eliminating the need for an α1-adrenergic blockers.
authors.affiliation: Division of Cardiology, Department of Medicine, School of Medicine, University of Colorado, Aurora, Colorado, USA.
authors.forename: Colleen K
authors.initials: CK
authors.lastname: Rohrer
authors.forename: Robert Lee
authors.initials: RL
authors.lastname: Page
authors.forename: Simon F
authors.initials: SF
authors.lastname: Shakar
authors.forename: Joann
authors.initials: J
authors.lastname: Lindenfeld
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000368:Aged; D017298:Bisoprolol / Q000009:adverse effects*; D002227:Carbazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D000077261:Carvedilol; D006333:Heart Failure / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D011412:Propanolamines / Q000008:administration & dosage / Q000627:therapeutic use*; D011470:Prostatic Hyperplasia / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D016055:Urinary Retention / Q000139:chemically induced
chemical_list: D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D011412:Propanolamines; D000077261:Carvedilol; D017298:Bisoprolol