title: Application of radiotherapy and chemotherapy protocols to pre-clinical tumor models.
abstract: This unit (1) provides background into understanding how agents that target specific molecules or receptors (molecular-targeted agents), in particular, agents affecting the tumor vasculature (perivasculature network in tumors), interact with and modify radiation therapy; (2) details factors affecting interpretation of results in murine tumor model experiments utilizing radiation therapy and drug combinations; and (3) provides specific protocols for the application of radiation therapy, both alone and in combination with chemotherapy and/or molecular-targeted agents.
authors.affiliation: University of Arizona, Tucson, Arizona, USA.
authors.forename: Randy
authors.initials: R
authors.lastname: Burd
authors.forename: Phyllis
authors.initials: P
authors.lastname: Wachsberger
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000818:Animals; D015687:Cell Hypoxia; D004195:Disease Models, Animal; D019788:Fluorodeoxyglucose F18; D006801:Humans; D051379:Mice; D016513:Mice, SCID; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000532:radiotherapy*; D010101:Oxygen Consumption; D023041:Xenograft Model Antitumor Assays
chemical_list: D020533:Angiogenesis Inhibitors; D019788:Fluorodeoxyglucose F18