title: Inflammatory signaling in Alzheimer disease and depression.
abstract: To help define the relationships among inflammation, Alzheimer disease, and depression, the Texas Alzheimer's Research Consortium analyzed an array of inflammatory biomarkers in a cohort of patients with Alzheimer disease and in controls. Inflammation severity was highly correlated with earlier age at onset of Alzheimer disease and was also associated with cognitive decline. The relationship between inflammation and depression was not as clear, and it varied with aspects of depression, gender, and the presence of Alzheimer disease.
authors.affiliation: Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer's Disease Research, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107, USA. Robert.Barber@unthsc.edu
authors.forename: Robert
authors.initials: R
authors.lastname: Barber
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology / Q000473:pathology*; D002097:C-Reactive Protein; D003071:Cognition; D016207:Cytokines; D003863:Depression / Q000209:etiology / Q000473:pathology*; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000473:pathology*; D012307:Risk Factors; D015398:Signal Transduction
chemical_list: D016207:Cytokines; D002097:C-Reactive Protein