title: Relationship between recurrent miscarriage and insulin resistance.
abstract: OBJECTIVE
  To investigate the differences in insulin resistance between women with recurrent miscarriage and those with normal pregnancy.
  
  
  METHODS
  Pregnant women with a history of recurrent miscarriage were included in the patient group (n = 97), while those with no history of abnormal pregnancy were included in the control group (n = 52). Both groups consented to undertake an oral glucose tolerance test and insulin-releasing test between the 5th and 13th weeks of pregnancy.
  
  
  RESULTS
  (1) Levels of fasting plasma glucose, fasting plasma insulin, homeostasis model assessment of insulin resistance index, and homeostasis model assessment β function were not statistically significantly different (p < 0.05) between the two groups. (2) The area under the curve of glucose and area under the curve of insulin were higher in the patient group than in the control group. The composite insulin sensitivity index of the patient group was lower than that of the control group. The differences in these three parameters between the groups were statistically significant (p < 0.05).
  
  
  CONCLUSIONS
  Women with a history of recurrent miscarriage are at an increased risk for insulin resistance during the first trimester of a new pregnancy.
authors.affiliation: Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. why48100@163.com
authors.forename: Yunhui
authors.initials: Y
authors.lastname: Wang
authors.forename: Huidan
authors.initials: H
authors.lastname: Zhao
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Jianping
authors.initials: J
authors.lastname: Zhang
authors.forename: Jianping
authors.initials: J
authors.lastname: Tan
authors.forename: Yukun
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000026:Abortion, Habitual / Q000503:physiopathology*; D000328:Adult; D001786:Blood Glucose; D016022:Case-Control Studies; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000502:physiology*; D012307:Risk Factors; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007328:Insulin