title: Analysis of some biochemical and haematological parameters for Mucuna pruriens (DC) seed powder in male rats.
abstract: The biochemical and haematological effects of the seed powder of Mucuna pruriens in male rats were evaluated to establish some biological properties of this potential biopesticide currently undergoing investigation. The result showed that Mucuna pruriens seed extract produced a significant (p<0.05) increase in white blood cell (WBC) count, as well as in bilirubin concentrations, alkaline phosphatase (ALP), protein and creatinine levels measured. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were significantly reduced (P<0.05) in comparison with the experimental control. PCV, Hb, albumin level and WBC differential counts gave no significant difference between treated and control groups. The results revealed metabolic imbalance in the rats which suggests a mild cholestasis effect of the extract.
authors.affiliation: Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, University of Jos, Nigeria. chuksemail@yahoo.com
authors.forename: Ndukwe Henry
authors.initials: NH
authors.lastname: Chukwudi
authors.forename: Omale
authors.initials: O
authors.lastname: Simeon
authors.forename: Aguiyi John
authors.initials: AJ
authors.lastname: Chinyere
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D001769:Blood / Q000187:drug effects* / Q000378:metabolism; D001786:Blood Glucose / Q000187:drug effects; D003404:Creatinine / Q000097:blood; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007928:Lethal Dose 50; D007958:Leukocyte Count; D018655:Lymphocyte Count; D008297:Male; D031299:Mucuna / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D011208:Powders; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry*; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D006454:Hemoglobins; D010936:Plant Extracts; D011208:Powders; D012709:Serum Albumin; D003404:Creatinine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin