title: "Cofactor"-controlled enantioselective catalysis.
abstract: We report an achiral bisphosphine rhodium complex equipped with a binding site for the recognition of chiral anion guests. Upon binding small chiral guests--cofactors--the rhodium complex becomes chiral and can thus be used for asymmetric catalysis. Screening of a library of cofactors revealed that the best cofactors lead to hydrogenation catalysts that form the products with high enantioselectivity (ee's up to 99%). Interestingly, a competition experiment shows that even in a mixture of 12 cofactors high ee is obtained, indicating that the complex based on the best cofactor dominates the catalysis.
authors.affiliation: Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Paweł
authors.initials: P
authors.lastname: Dydio
authors.forename: Christophe
authors.initials: C
authors.lastname: Rubay
authors.forename: Tendai
authors.initials: T
authors.lastname: Gadzikwa
authors.forename: Martin
authors.initials: M
authors.lastname: Lutz
authors.forename: Joost N H
authors.initials: JN
authors.lastname: Reek
mesh_terms: D002384:Catalysis; D009942:Organometallic Compounds / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D009942:Organometallic Compounds; D010720:Phosphines; D012238:Rhodium