title: Synthetic applications of the nickel-catalyzed cyclization of alkynes combined with addition reactions in a domino process.
abstract: Carbonickelations of alkynes and functionalization of the resulting vinylnickel moiety have been performed efficiently in a nickel-catalyzed domino cyclization-condensation process. This reaction, which does not require the preparation of any other organometallic reagent, proceeds only by exo-dig cyclization. This convenient and mild method constitutes a one-pot synthesis of substituted dihydrobenzofurans, chromans, isochromans, indoles, or indanes. Theses valuable products are generally obtained in good yields and high stereoselectivity. They are shown to be useful synthons for rapid access to functionalized polycyclic skeletons.
authors.affiliation: Laboratoire des Fonctions Azotées & Oxygénées Complexes de l'IRCOF, CNRS UMR 6014 & FR 3038, Université de Rouen et INSA de Rouen, Mont St Aignan, France. muriel.durandetti@univ-rouen.fr
authors.forename: Muriel
authors.initials: M
authors.lastname: Durandetti
authors.forename: Lucie
authors.initials: L
authors.lastname: Hardou
authors.forename: Rudy
authors.initials: R
authors.lastname: Lhermet
authors.forename: Mathieu
authors.initials: M
authors.lastname: Rouen
authors.forename: Jacques
authors.initials: J
authors.lastname: Maddaluno