title: Acetylator status and N-acetyltransferase 2 gene polymorphisms; phenotype-genotype correlation with the sulfamethazine test.
abstract: N-acetyltransferase 2 (NAT2) catalyzes the bioactivation and/or detoxification of drugs and carcinogens. The aim of this study was to establish the correlation between the NAT2 genotype and the acetylating phenotype in a Mexican population using sulfamethazine as a probe. From a total of 122 individuals, 73 (59.8%) were slow and 49 (40.2%) were fast acetylators. Eleven individuals (9%) had the wild-type genotype (NAT2*4/NAT2*4). The most frequent genotype was NAT2*4/NAT2*5B observed in 20.66% of individuals. In conclusion, our results show that an accurate prediction of the acetylation phenotype by genotyping can be achieved in around half of the population. Further studies with a larger number of individuals are required to establish correlations between phenotype and genotype in half of that patients having a genotype combined with slow/rapid alleles.
authors.affiliation: Laboratory of Epigenetics, Division of Basic Research, Instituto Nacional de Cancerología, Mexico City, Mexico.
authors.forename: Lucia
authors.initials: L
authors.lastname: Taja-Chayeb
authors.forename: Aurora
authors.initials: A
authors.lastname: González-Fierro
authors.forename: Cristian
authors.initials: C
authors.lastname: Miguez-Muñoz
authors.forename: Catalina
authors.initials: C
authors.lastname: Trejo-Becerril
authors.forename: Erick de la
authors.initials: Ede L
authors.lastname: Cruz-Hernandez
authors.forename: David
authors.initials: D
authors.lastname: Cantu
authors.forename: Jose A
authors.initials: JA
authors.lastname: Agundez
authors.forename: Silvia
authors.initials: S
authors.lastname: Vidal-Millan
authors.forename: Olga
authors.initials: O
authors.lastname: Gutierrez
authors.forename: Alfonso
authors.initials: A
authors.lastname: Dueñas-González
mesh_terms: D000107:Acetylation; D000328:Adult; D000368:Aged; D000483:Alleles; D001191:Arylamine N-Acetyltransferase / Q000235:genetics* / Q000378:metabolism; D002273:Carcinogens / Q000494:pharmacology*; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D011110:Polymorphism, Genetic; D013418:Sulfamethazine / Q000493:pharmacokinetics*
chemical_list: D002273:Carcinogens; D013418:Sulfamethazine; D001191:Arylamine N-Acetyltransferase; C478900:NAT2 protein, human