title: [Y-chromosome microdeletions do not affect the outcomes of ICSI for infertile males].
abstract: OBJECTIVE
  To compare the outcomes of intracytoplasmic sperm injection (ICSI) for infertile males with Y-chromosome microdeletions and for those with azoospermia or severe oligospermia but without Y-chromosome microdeletions.
  
  
  METHODS
  We retrospectively analyzed 56 cycles of ICSI for 48 infertile cases with Y microdeletions (Group A) and 94 cycles for 90 cases with azoospermia or severe oligospermia but without Y-chromosome microdeletions (Group B) during the same period. We compared the two groups in the females' age, duration of infertility, males' age, number of oocytes retrieved, number of ICSI oocytes, fertilization rate, good embryo rate, number of embryos transferred, implantation rate, clinical pregnancy rate, abortion rate, live birth rate and babies' sexes.
  
  
  RESULTS
  There were no significant differences between Groups A and B in the females' age, duration of infertility, males' age, number of oocytes retrieved, number of ICSI oocytes and number of embryos transferred (P > 0.05), nor in the rates of fertilization (69.0% vs 73.2%), good embryos (53.3% vs 48.7%), implantation (24.0% vs 30.3%), biochemical pregnancy (41.1% vs 44.7%), clinical pregnancy (37.5% vs 35.1%), early abortion (4.8% vs 6.1%) and live birth (35.7% vs 29.2%) (P > 0.05).
  
  
  CONCLUSIONS
  Y-chromosome microdeletions do not affect the outcomes of ICSI. The affected couples should be informed of the necessity of prenatal genetic diagnosis before embryo implantation and the inevitability of vertical transmission to male offspring.
authors.affiliation: Department of Reproductive Medicine, The First Affiliated Hospital, Nanjing, Jiangsu 210029, China. weiwu77@163.com
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.forename: Zuo-Ming
authors.initials: ZM
authors.lastname: Zhou
authors.forename: Min
authors.initials: M
authors.lastname: Lin
authors.forename: Yun-Dong
authors.initials: YD
authors.lastname: Mao
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Yang
authors.forename: Jia-Yin
authors.initials: JY
authors.lastname: Liu
mesh_terms: D000328:Adult; D053713:Azoospermia / Q000235:genetics / Q000628:therapy*; D002872:Chromosome Deletion; D041322:Chromosomes, Human, Y / Q000235:genetics; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000235:genetics / Q000628:therapy*; D008297:Male; D009845:Oligospermia / Q000235:genetics / Q000628:therapy*; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D012729:Sex Chromosome Aberrations; D058533:Sex Chromosome Disorders of Sex Development / Q000235:genetics / Q000628:therapy*; D020554:Sperm Injections, Intracytoplasmic; D016896:Treatment Outcome