title: Serum cystatin C and microalbuminuria in the detection of vascular and renal damage in early stages.
abstract: BACKGROUND
  The aim of this study was to assess serum cystatin C and urinary albumin in the early detection of impairment in cardiovascular and renal function. MATERIAL ANS METHODS: Cystatin C was quantified in sera from healthy people, moreover, cystatin C was quantified in a group of patients diagnosed with chronic kidney disease for predicting a measured glomerular filtration rate <60 ml/min/1.73 m2. Finally serum cystatin C and microalbuminuria were measured in patients with increasing of risk of impairment in cardiovascular and renal function (hypertension, diabetes and hyperlipidemia).
  
  
  RESULTS
  When the serum cystatin C was quantified in a group of risk, we observe as when being increased the cystatin C, the values of the glomerular filtration rate decreased (p <0.05), the cystatin values C were increased when increasing the age of the patients (p <0.05) and cystatin C values higher than 0.95 mg/l were not observed in patient smaller than 50 years old. In the group of risk, serum cystatin C was high regarding to the values obtained in healthy people in 27.6%, microalbuminuria in the 20.3% and both parameters were high in the 14.4% of patients with a glomerular filtration rate >90 ml/min/1.73 m2, while in patients with a glomerular filtration rate 60-90 ml/min/1.73 m2, cystatin C was high in the 51.7% and the microalbuminuria only in the 6.4%.
  
  
  CONCLUSIONS
  Determinations of serum cystatin C associated to the quantification of urinary albumin in patients with cardiovascular risk can optimize the early detection of vascular and renal damage. Cystatin C can show vascular and renal damage in patients without urinary albumin.
authors.affiliation: Clinical Analysis Department, Infanta Cristina University Hospital, Badajoz, Spain. lopezhospi@yahoo.es
authors.forename: J M
authors.initials: JM
authors.lastname: López Gómez
authors.forename: B
authors.initials: B
authors.lastname: Sacristán Enciso
authors.forename: M
authors.initials: M
authors.lastname: Micó
authors.forename: F
authors.initials: F
authors.lastname: Arias Meneses
authors.forename: F
authors.initials: F
authors.lastname: de Sande Medel
authors.forename: S
authors.initials: S
authors.lastname: Alejo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000419:Albuminuria / Q000097:blood*; D015415:Biomarkers; D002318:Cardiovascular Diseases / Q000097:blood* / Q000175:diagnosis; D002908:Chronic Disease; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D055312:Cystatin A / Q000097:blood*; D003920:Diabetes Mellitus / Q000097:blood / Q000453:epidemiology; D042241:Early Diagnosis; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000453:epidemiology; D006973:Hypertension / Q000097:blood / Q000453:epidemiology; D007674:Kidney Diseases / Q000097:blood* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014508:Urea / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D055312:Cystatin A; C026407:CSTA protein, human; D014508:Urea; D003404:Creatinine