title: A marked synergistic effect in antitumor activity of salan titanium(IV) complexes bearing two differently substituted aromatic rings.
abstract: Salan titanium(IV) complexes of differently substituted aromatic rings, where one ring is para-nitrated and another is ortho,para-halogenated, demonstrate exceptionally high anticancer activity, with IC(50) values of <1 μM, exceeding that of cisplatin by ~30-fold. Whereas an additive effect in hydrolytic stability was detected for these highly stable complexes, an unexpected synergistic effect in anticancer activity makes these hybrid complexes substantially more active than both their symmetrical analogues alone and their equimolar mixture.
authors.affiliation: Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem, 91904 Israel.
authors.forename: Hagai
authors.initials: H
authors.lastname: Glasner
authors.forename: Edit Y
authors.initials: EY
authors.lastname: Tshuva
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D019073:HT29 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D014025:Titanium / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D014025:Titanium