title: [Contribution of nitric oxide in the mechanisms of flow-dependent vasodilation in normo- and hypertensive rats].
abstract: The aim of this study was to evaluate the role of nitric oxide (NO) in the mechanisms of arterial distensibility and intravascular pressure stability in normotensive and spontaneously hypertensive rats. The experiments were performed on the anesthetized male Wistar, Wistar-Kyoto (WKY), and spontaneously hypertensive rats (SHR). The abdominal aorta was cannulated and perfused with variable blood flow rates with subsequent determination of major characteristics of regional vascular function. The blockade of nitric oxide (NO) synthase resulted in the increase in hydraulic resistance of the hindlimb vascular bed in all series of the experiments. It was associated with the decrease in the intravascular pressure stability. The obtained results provide further evidence for an important role of NO in the formation of conductivity and stability of the arterial pressure both in normo- and hypertensive rats. However, the involvement of NO in the phenomenon of flow-dependent vasodilation in SHR is unlikely. The major difference between SHR and normotensive rats involved the ability of the resistive arteries of SHR to enhance vascular conductivity in response to blood flow enhancement. Presumably, there are some unidentified additional factors that are involved in the flow-dependent vasodilation in SHR.
authors.forename: D L
authors.initials: DL
authors.lastname: Sonin
authors.forename: M M
authors.initials: MM
authors.lastname: Galagudza
authors.forename: A V
authors.initials: AV
authors.lastname: Syrenskiĭ
authors.forename: E I
authors.initials: EI
authors.lastname: Egorova
authors.forename: M K
authors.initials: MK
authors.lastname: Nekrasova
authors.forename: V A
authors.initials: VA
authors.lastname: Tsyrlin
mesh_terms: D000465:Algorithms; D000818:Animals; D001158:Arteries / Q000503:physiopathology; D001794:Blood Pressure; D002404:Catheterization; D004791:Enzyme Inhibitors / Q000009:adverse effects / Q000494:pharmacology*; D006439:Hemodynamics; D006940:Hyperemia / Q000139:chemically induced / Q000503:physiopathology; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D019335:Nitroarginine / Q000009:adverse effects / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D017208:Rats, Wistar; D014655:Vascular Resistance / Q000502:physiology*; D014664:Vasodilation / Q000187:drug effects
chemical_list: D004791:Enzyme Inhibitors; D019335:Nitroarginine; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase