title: Effect of interval between transcatheter hepatic arterial embolization and radiofrequency ablation on ablated lesion size in a swine model.
abstract: OBJECTIVE
  The aim of the study was to clarify the effect of the interval between transcatheter hepatic arterial embolization (TAE) with Lipiodol plus gelatin sponge particles and radiofrequency (RF) ablation on the extent of ablation.
  
  
  METHODS
  Eight healthy swine were divided into four groups: RF ablation (ablation only), RF ablation immediately after TAE (immediate ablation), RF ablation 3 days after TAE (3-day ablation), and RF ablation 6 days after TAE (6-day ablation). Five ablated lesions were created in each swine (10 per group). A 2-cm expandable LeVeen needle electrode was used for RF ablation. Ablated lesions are composed of an outer reddish zone and an inner whitish zone.
  
  
  RESULTS
  The average longest length of the major, intermediate, and minor axes and the volume in the immediate ablation, 3-day ablation, and 6-day ablation groups were significant longer and greater (1.52 and 1.52, 1.46 and 1.50, and 1.37 and 1.35 times greater in the red zone and the whitish area, respectively) than those in the ablation-only group (P < 0.05/3). Accumulation of Lipiodol was still noted in the hepatic sinusoids in the 3-day and 6-day ablation groups.
  
  
  CONCLUSIONS
  RF ablation delayed to 6 days following TAE produced larger ablation volumes than did RF ablation alone.
authors.affiliation: Department of Radiology, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8510, Japan.
authors.forename: Cao
authors.initials: C
authors.lastname: Guang
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kawai
authors.forename: Morio
authors.initials: M
authors.lastname: Sato
authors.forename: Isao
authors.initials: I
authors.lastname: Takasaka
authors.forename: Hiroki
authors.initials: H
authors.lastname: Minamiguchi
authors.forename: Shinya
authors.initials: S
authors.lastname: Sahara
authors.forename: Kouhei
authors.initials: K
authors.lastname: Nakata
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Sonomura
authors.forename: Shintaro
authors.initials: S
authors.lastname: Shirai
authors.forename: Ichiro
authors.initials: I
authors.lastname: Mori
authors.forename: Renjie
authors.initials: R
authors.lastname: Yang
mesh_terms: D000818:Animals; D017115:Catheter Ablation / Q000379:methods*; D004621:Embolization, Therapeutic / Q000379:methods*; D004998:Ethiodized Oil / Q000008:administration & dosage; D005260:Female; D005781:Gelatin Sponge, Absorbable / Q000008:administration & dosage; D008099:Liver / Q000473:pathology / Q000601:surgery*; D023421:Models, Animal; D013552:Swine; D013997:Time Factors
chemical_list: D004998:Ethiodized Oil