title: [Application thymogen for preoperative preparation of elderly patients with tumor processes in abdominal cavity].
abstract: A double-blind, randomized, placebo-controlled study of the efficacy of Thymogen preparation for elderly patients for surgery on the solid tumors in abdominal cavity and retroperitoneal space was carried out. The drug has been administered by intranasal instillation of 100 mg once a day for 7 days before surgery. The isotonic sodium chloride solution for the placebo group in the same scheme was used. The preoperative use of Thymogen proved to be useful to restore the structural and functional parameters of cellular immunity. Immunomodulatory therapy resulted in the significant decrease in the number and range of post-operative complications and the shorting of the postoperative period.
authors.forename: V S
authors.initials: VS
authors.lastname: Smirnov
authors.forename: S V
authors.initials: SV
authors.lastname: Petlenko
authors.forename: S S
authors.initials: SS
authors.lastname: El'tsin
mesh_terms: D034841:Abdominal Cavity; D000008:Abdominal Neoplasms / Q000601:surgery*; D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000187:drug effects* / Q000276:immunology; D004151:Dipeptides / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D056747:Immunomodulation; D008297:Male; D011300:Preoperative Care; D012186:Retroperitoneal Neoplasms / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D000276:Adjuvants, Immunologic; D004151:Dipeptides; C060736:thymogen