title: The effect of menopause on the skin and other connective tissues.
abstract: Cutaneous ageing manifests itself as a progressive reduction in function and reserve capacity of skin tissue. Collagen atrophy is a major factor in skin ageing. There is a strong correlation between skin collagen loss and oestrogen deficiency due to the menopause. Skin ageing is associated with a progressive increase in extensibility and a reduction in elasticity. With increasing age, the skin also becomes more fragile and susceptible to trauma, leading to more lacerations and bruising. Furthermore, wound healing is impaired in older women. Oestrogen use after the menopause increases collagen content, dermal thickness and elasticity, and it decreases the likelihood of senile dry skin. Large-scale clinical trials are necessary to help make informed recommendations regarding postmenopausal oestrogen use and its role in the prevention of skin ageing. Oestrogen has profound effects on connective tissue turnover, no matter the site. It has been shown that menopause has similar effects on the connective tissue of the carotid artery media, intervertebral discs and bones.
authors.affiliation: Department of Anatomy, Faculty of Medicine and Surgery, University of Malta, Tal-Qroqq, Malta. jean.calleja-agius@um.edu.mt
authors.forename: J
authors.initials: J
authors.lastname: Calleja-Agius
authors.forename: M
authors.initials: M
authors.lastname: Brincat
mesh_terms: D003238:Connective Tissue / Q000502:physiology*; D004548:Elasticity; D005260:Female; D006801:Humans; D008593:Menopause / Q000502:physiology*; D012867:Skin; D012879:Skin Physiological Phenomena; D014945:Wound Healing / Q000502:physiology*