title: Clinicopathologic features of intraductal papillary neoplasm of the bile duct according to histologic subtype.
abstract: OBJECTIVE
  Despite an increase in the reports of intraductal papillary neoplasm of the bile duct (IPN-B), the clinical characteristics and long-term prognosis of this disease are not well known compared with those of intraductal papillary mucinous neoplasms of the pancreas. The objective of our study was to compare the clinical features, radiologic findings, and clinical outcomes of IPN-B according to histologic subtype.
  
  
  METHODS
  A retrospective analysis was performed on the medical records of 97 patients diagnosed with IPN-B by pathologic analysis of their surgical specimens between May 1995 and May 2010. We compared the clinical manifestations, radiological findings, pathologic grade, curative resection rate, recurrence, and overall survival according to four histologic subtypes: gastric (n=15), intestinal (n=46), pancreaticobiliary (n=33), and oncocytic (n=3), which were classified on the basis of hematoxylin and eosin staining and the immunohistochemical profile of mucin core proteins.
  
  
  RESULTS
  Mucin hypersecretion was significantly more frequent in patients with gastric and intestinal types than it was in those with oncocytic and pancreaticobiliary types (P=0.014). There were no significant differences between groups regarding the presence of bile duct stones or tumor location. The frequency of invasive carcinoma in the pancreaticobiliary type was significantly higher than those in the gastric and intestinal types (72.7 vs. 26.7 and 32.6%, P<0.001 and P<0.001). When comparing the survival curves according to histologic subtype, patients with pancreaticobiliary type demonstrated significantly worse survival compared to those with gastric and intestinal types (P=0.035).
  
  
  CONCLUSIONS
  Gastric and intestinal types of IPN-B have similar clinical characteristics compared with the pancreaticobiliary type, which has a worse prognosis.
authors.affiliation: Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
authors.forename: Kwang Min
authors.initials: KM
authors.lastname: Kim
authors.forename: Jong Kyun
authors.initials: JK
authors.lastname: Lee
authors.forename: Jae Uk
authors.initials: JU
authors.lastname: Shin
authors.forename: Kwang Hyuck
authors.initials: KH
authors.lastname: Lee
authors.forename: Kyu Taek
authors.initials: KT
authors.lastname: Lee
authors.forename: Ji-Youn
authors.initials: JY
authors.lastname: Sung
authors.forename: Kee-Taek
authors.initials: KT
authors.lastname: Jang
authors.forename: Jin Seok
authors.initials: JS
authors.lastname: Heo
authors.forename: Seong-Ho
authors.initials: SH
authors.lastname: Choi
authors.forename: Dong Wook
authors.initials: DW
authors.lastname: Choi
authors.forename: Jae Hoon
authors.initials: JH
authors.lastname: Lim
mesh_terms: D001650:Bile Duct Neoplasms / Q000145:classification* / Q000473:pathology*; D002291:Carcinoma, Papillary / Q000145:classification* / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies