title: Mass spectrometry in systems biology an introduction.
abstract: The qualitative detection, quantification, and structural characterization of analytes in biological systems are important requirements for objectives to be fulfilled in systems biology research. One analytical tool applied to a multitude of systems biology studies is mass spectrometry, particularly for the study of proteins and metabolites. Here, the role of mass spectrometry in systems biology will be assessed, the advantages and disadvantages discussed, and the instrument configurations available described. Finally, general applications will be briefly reviewed.
authors.affiliation: Manchester Centre for Integrative Systems Biology, Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, United Kingdom.
authors.forename: Warwick B
authors.initials: WB
authors.lastname: Dunn
mesh_terms: D000818:Animals; D005583:Fourier Analysis; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D055442:Metabolome; D008970:Molecular Weight; D020543:Proteome / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*; D049490:Systems Biology / Q000379:methods*
chemical_list: D020543:Proteome