title: Analyses related to the development of DSM-5 criteria for substance use related disorders: 1. Toward amphetamine, cocaine and prescription drug use disorder continua using Item Response Theory.
abstract: BACKGROUND
  Prior research has demonstrated the dimensionality of alcohol, nicotine and cannabis use disorders criteria. The purpose of this study was to examine the unidimensionality of DSM-IV cocaine, amphetamine and prescription drug abuse and dependence criteria and to determine the impact of elimination of the legal problems criterion on the information value of the aggregate criteria.
  
  
  METHODS
  Factor analyses and Item Response Theory (IRT) analyses were used to explore the unidimensionality and psychometric properties of the illicit drug use criteria using a large representative sample of the U.S. population.
  
  
  RESULTS
  All illicit drug abuse and dependence criteria formed unidimensional latent traits. For amphetamines, cocaine, sedatives, tranquilizers and opioids, IRT models fit better for models without legal problems criterion than models with legal problems criterion and there were no differences in the information value of the IRT models with and without the legal problems criterion, supporting the elimination of that criterion.
  
  
  CONCLUSIONS
  Consistent with findings for alcohol, nicotine and cannabis, amphetamine, cocaine, sedative, tranquilizer and opioid abuse and dependence criteria reflect underlying unitary dimensions of severity. The legal problems criterion associated with each of these substance use disorders can be eliminated with no loss in informational value and an advantage of parsimony. Taken together, these findings support the changes to substance use disorder diagnoses recommended by the American Psychiatric Association's DSM-5 Substance and Related Disorders Workgroup.
authors.affiliation: Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5635 Fishers Lane, Bethesda, MD 20892-9304, USA.
authors.forename: Tulshi D
authors.initials: TD
authors.lastname: Saha
authors.forename: Wilson M
authors.initials: WM
authors.lastname: Compton
authors.forename: S Patricia
authors.initials: SP
authors.lastname: Chou
authors.forename: Sharon
authors.initials: S
authors.lastname: Smith
authors.forename: W June
authors.initials: WJ
authors.lastname: Ruan
authors.forename: Boji
authors.initials: B
authors.lastname: Huang
authors.forename: Roger P
authors.initials: RP
authors.lastname: Pickering
authors.forename: Bridget F
authors.initials: BF
authors.lastname: Grant
mesh_terms: D019969:Amphetamine-Related Disorders / Q000175:diagnosis*; D019970:Cocaine-Related Disorders / Q000175:diagnosis*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D006801:Humans; D013287:Illicit Drugs; D056687:Off-Label Use; D055553:Prescription Drugs; D011594:Psychometrics
chemical_list: D013287:Illicit Drugs; D055553:Prescription Drugs