title: Periventricular white matter injury by primary intraventricular hemorrhage: a diffusion tensor imaging study.
abstract: OBJECTIVE
  Intraventricular hemorrhage (IVH) in adult stroke patients is known to be an independent risk factor for poor functional outcome. Using diffusion tensor imaging (DTI), we attempted to investigate the effect of IVH on the white matter.
  
  
  METHODS
  We recruited 10 consecutive patients with IVH and 18 age- and sex-matched control subjects. Using a 1.5-T Philips Gyroscan Intera system, DTI data was acquired at an average of 84 days (range: 38-149) after IVH onset. We measured fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values at the fornix, corpus callosum (CC), corona radiata (CR), and posterior limb of the internal capsule (PL). In addition, integrity and fiber number were measured for the fornix.
  
  
  RESULTS
  DTI revealed disruption of the fornix in all patients. FA values showed a decrease in the fornix, CC, and CR; in contrast, the ADC value showed an increase in the CC, without changes in the fornix or CR. Fiber number of the fornix also decreased. However, no change was observed in the PL.
  
  
  CONCLUSIONS
  We found periventricular white matter (fornix, CC, and CR) injury following IVH. We think that this result would be helpful in the establishment of management strategies for patients with IVH.
authors.affiliation: Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Taegu, Republic of Korea.
authors.forename: Sang Seok
authors.initials: SS
authors.lastname: Yeo
authors.forename: Byung Yeon
authors.initials: BY
authors.lastname: Choi
authors.forename: Chul Hoon
authors.initials: CH
authors.lastname: Chang
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Jung
authors.forename: Sang Ho
authors.initials: SH
authors.lastname: Ahn
authors.forename: Su Min
authors.initials: SM
authors.lastname: Son
authors.forename: Woo Mok
authors.initials: WM
authors.lastname: Byun
authors.forename: Sung Ho
authors.initials: SH
authors.lastname: Jang
mesh_terms: D000328:Adult; D016880:Anisotropy; D001931:Brain Mapping; D016022:Case-Control Studies; D002543:Cerebral Hemorrhage / Q000150:complications / Q000175:diagnosis*; D002552:Cerebral Ventricles / Q000473:pathology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology; D003337:Corpus Callosum / Q000473:pathology*; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000175:diagnosis / Q000209:etiology; D018709:Statistics, Nonparametric