title: [Adaptive hypometabolism in man].
abstract: Two hypotheses of functional organization of hypoxic hypometabolism in man is discussed. One is a bioenergetic hypothesis stating that progressive oxygen deficiency in the cells leads to suppression of macrophage production. The other regards hypometabolism as a result of decreased energy consumption in response to hypoxia or the lack of energy of any etiology; it results in impaired intensity of energy metabolism. The letter strategy is underlain by central regulatory mechanisms for which proteins of the HIF-factor system are the most probable markers.
authors.forename: O V
authors.initials: OV
authors.lastname: Grishin
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D015415:Biomarkers; D031204:Caloric Restriction / Q000009:adverse effects; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000150:complications / Q000378:metabolism; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000097:blood*; D008297:Male; D008660:Metabolism / Q000502:physiology*; D010101:Oxygen Consumption / Q000502:physiology; D013312:Stress, Physiological
chemical_list: D015415:Biomarkers; D051795:Hypoxia-Inducible Factor 1, alpha Subunit