title: Xenon-inhalation computed tomography for noninvasive quantitative measurement of tissue blood flow in pancreatic tumor.
abstract: OBJECTIVE
  The purpose of this prospective study was to demonstrate the ability to measure pancreatic tumor tissue blood flow (TBF) with a noninvasive method using xenon inhalation computed tomography (xenon-CT) and to correlate TBF with histological features, particularly microvascular density (MVD).
  
  
  METHODS
  TBFs of pancreatic tumors in 14 consecutive patients were measured by means of xenon-CT at diagnosis and following therapy. Serial abdominal CT scans were obtained before and after inhalation of nonradioactive xenon gas. TBF was calculated using the Fick principle. Furthermore, intratumoral microvessels were stained with anti-CD34 monoclonal antibodies before being quantified by light microscopy (×200). We evaluated MVD based on CD34 expression and correlated it with TBF.
  
  
  RESULTS
  The quantitative TBF of pancreatic tumors measured by xenon CT ranged from 22.3 to 111.4 ml/min/100 g (mean ± SD, 59.6 ± 43.9 ml/min/100 g). High correlation (r = 0.885, P < 0.001) was observed between TBF and intratumoral MVD.
  
  
  CONCLUSIONS
  Xenon-CT is feasible in patients with pancreatic tumors and is able to accurately estimate MVD noninvasively.
authors.affiliation: Department of Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita-city, Osaka 565-0871, Japan. mk3306@columbia.edu
authors.forename: Masaru
authors.initials: M
authors.lastname: Kubota
authors.forename: Takamichi
authors.initials: T
authors.lastname: Murakami
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nagano
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Eguchi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Marubashi
authors.forename: Shogo
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Wada
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tanemura
authors.forename: Keizo
authors.initials: K
authors.lastname: Dono
authors.forename: Shoji
authors.initials: S
authors.lastname: Nakamori
authors.forename: Masato
authors.initials: M
authors.lastname: Sakon
authors.forename: Morito
authors.initials: M
authors.lastname: Monden
authors.forename: Masaki
authors.initials: M
authors.lastname: Mori
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Doki
mesh_terms: D000230:Adenocarcinoma / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D018273:Carcinoma, Islet Cell / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D021441:Carcinoma, Pancreatic Ductal / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D005240:Feasibility Studies; D015408:Gastrinoma / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008833:Microcirculation; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging / Q000473:pathology; D018358:Neuroendocrine Tumors / Q000098:blood supply* / Q000000981:diagnostic imaging* / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging* / Q000473:pathology; D055420:Perfusion Imaging / Q000379:methods; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014978:Xenon
chemical_list: D014978:Xenon