title: Patterning and development of the atrioventricular canal in zebrafish.
abstract: Proper atrioventricular canal (AVC) patterning and subsequent valvulogenesis is a complex process, and defects can result in disease or early death. The zebrafish Danio rerio has become a useful model system for studying AVC development, and much progress has been made in dissecting out the critical steps. Here, we review the recent advances in the field and highlight the cellular and molecular changes observed during zebrafish AVC development.
authors.affiliation: Cardiovascular Research Center and Cardiac Arrhythmia Service, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown, Boston, MA 02129, USA.
authors.forename: David S
authors.initials: DS
authors.lastname: Peal
authors.forename: Stacey N
authors.initials: SN
authors.lastname: Lynch
authors.forename: David J
authors.initials: DJ
authors.lastname: Milan
mesh_terms: D000818:Animals; D019521:Body Patterning; D054089:Endocardial Cushions / Q000196:embryology* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006351:Heart Valves / Q000196:embryology* / Q000378:metabolism; D009024:Morphogenesis; D015398:Signal Transduction; D015027:Zebrafish / Q000196:embryology* / Q000235:genetics / Q000378:metabolism