title: Influence of clonidine on the chemodynamic stability and stress response in the course of surgery on general anesthesia.
abstract: This work provides results of therapeutic efficacy testing and clonidine toleration in moderating of perioperative tachicardia and hypertension, as well as reducing the needs for anaestathic drugs, thus providing better patients' cardiovascular stability.
  
  
  METHODS
  The study involved 60 patients, that were subdued to elective non-cardiosurgical operations in general anaesthesia. One half of the patients was administred the Clonidine, 0.2 microg/kg/min in solution, while the other half served as a control group.
  
  
  RESULTS
  of the study it was evident that the Clonidine group had considerably less stress response, which was shown through variaton of cortisol levels during operation, glicemy levels and vital parameters. There was a statisticly significant difference (p < 0.001) in cortisol serum levels and glicemy beetwen these two groups. Complications during anesthesia were fewer in the Clonidine group, and the consumption of anesthetic drugs was also lower.
  
  
  CONCLUSIONS
  Clonidine effects were favourable during anaesthesia.
authors.affiliation: Department of Anesthesiology, Intensive care and Treatment of Pain, Cantonal Hospital Zenica, Bosnia and Herzegovina.
authors.forename: Merlina
authors.initials: M
authors.lastname: Kalajdzija
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Cero
authors.forename: Besim
authors.initials: B
authors.lastname: Prnjavorac
authors.forename: Senad
authors.initials: S
authors.lastname: Ljuca
mesh_terms: D000759:Adjuvants, Anesthesia / Q000008:administration & dosage*; D058647:Adrenergic alpha-2 Receptor Agonists / Q000008:administration & dosage*; D000328:Adult; D000768:Anesthesia, General; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects; D003000:Clonidine / Q000008:administration & dosage*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D013312:Stress, Physiological; D013514:Surgical Procedures, Operative / Q000009:adverse effects*
chemical_list: D000759:Adjuvants, Anesthesia; D058647:Adrenergic alpha-2 Receptor Agonists; D001786:Blood Glucose; D003000:Clonidine; D006854:Hydrocortisone