title: The fruits of Cudrania tricuspidata suppress development of atopic dermatitis in NC/Nga mice.
abstract: The fruits of Cudrania tricuspidata are a medicinal herb in Korea, known for its antiatherosclerotic and antiinflammatory effects. Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by the influx of lymphocytes into the dermis. Using an animal model of AD, we assessed whether C. tricuspidata suppresses the development of AD-like skin lesions. Cudrania tricuspidata was administered orally to NC/Nga mice with Dermatophagoides-farinae-induced AD-like lesions for 49 days. The effects of C. tricuspidata were assessed by measuring clinical symptoms, swelling of the skin on the back and ears, and plasma concentrations of mTARC (mouse thymus and activation regulated chemokine), histamine and immunoglobulin E (IgE). We found that C. tricuspidata (60 mg/kg/day) inhibited the development of AD-like skin lesions, reduced skin dermatitis scores and inhibited the histological changes induced by repeated application of D. farinae. In addition, C. tricuspidata inhibited the increases in plasma concentrations of mTARC, histamine and IgE induced by D. farinae. These findings indicate that C. tricuspidata inhibits the development of AD-like skin lesions induced by repeated applications of D. farinae in sensitized NC/Nga by suppressing plasma concentrations of mTARC, histamine and IgE.
authors.affiliation: Herbal Medicine EBM Research Center, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea.
authors.forename: Hoyoung
authors.initials: H
authors.lastname: Lee
authors.forename: Hyekyung
authors.initials: H
authors.lastname: Ha
authors.forename: Jun Kyung
authors.initials: JK
authors.lastname: Lee
authors.forename: Chang-Seob
authors.initials: CS
authors.lastname: Seo
authors.forename: Nam-Hun
authors.initials: NH
authors.lastname: Lee
authors.forename: Da-Young
authors.initials: DY
authors.lastname: Jung
authors.forename: Sang-Joon
authors.initials: SJ
authors.lastname: Park
authors.forename: Hyeun Kyoo
authors.initials: HK
authors.lastname: Shin
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology*; D054414:Chemokine CCL17 / Q000097:blood; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000469:parasitology / Q000473:pathology; D040001:Dermatophagoides farinae / Q000276:immunology / Q000472:pathogenicity; D004353:Drug Evaluation, Preclinical; D005638:Fruit / Q000737:chemistry*; D006632:Histamine / Q000097:blood; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D051379:Mice; D015394:Molecular Structure; D029586:Moraceae / Q000737:chemistry*; D011239:Prednisolone / Q000097:blood; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; C499538:Ccl17 protein, mouse; D054414:Chemokine CCL17; D007073:Immunoglobulin E; D006632:Histamine; D011239:Prednisolone