title: Perfluoroalkylation in flow microreactors: generation of perfluoroalkyllithiums in the presence and absence of electrophiles.
abstract: Perfluoroalkyllithiums were effectively generated from perfluoroalkyl halides in the presence and absence of electrophiles using flow microreactor systems. The in situ trapping with electrophile is conducted at much higher temperatures than those required for batch macro reactors. The subsequent trapping method is quite effective for highly reactive electrophiles that are not compatible with the lithiation process.
authors.affiliation: Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, 615-8510, Kyoto, Japan.
authors.forename: Aiichiro
authors.initials: A
authors.lastname: Nagaki
authors.forename: Shinya
authors.initials: S
authors.lastname: Tokuoka
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Yamada
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Tomida
authors.forename: Kojun
authors.initials: K
authors.lastname: Oshiro
authors.forename: Hideki
authors.initials: H
authors.lastname: Amii
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Yoshida
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000478:Alkylation; D008094:Lithium / Q000737:chemistry*; D046210:Microfluidic Analytical Techniques; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000447:Aldehydes; D009942:Organometallic Compounds; D008094:Lithium