title: Isolation of talathermophilins from the thermophilic fungus Talaromyces thermophilus YM3-4.
abstract: Six indole alkaloids with various levels of prenylation were isolated from the thermophilic fungus  Talaromyces thermophilus  strain YM3-4. Their structures were identified by NMR and MS spectroscopic analyses. Compounds 1 and 2 are new analogues of the key versatile precursor notoamide E. Compound 3 is a novel analogue of preechinulin, and compound 4 was reported as a natural occurring cyclo(glycyltryptophyl) for the first time. The metabolite profile of this thermophilic organism displayed a biosynthetic pathway for talathermophilins.
authors.affiliation: Laboratory for Conservation and Utilization of Bio-Resources, Yunnan University, Kunming 650091, People's Republic of China.
authors.forename: Ji-Peng
authors.initials: JP
authors.lastname: Guo
authors.forename: Jian-Lin
authors.initials: JL
authors.lastname: Tan
authors.forename: Yan-Li
authors.initials: YL
authors.lastname: Wang
authors.forename: Hong-Yang
authors.initials: HY
authors.lastname: Wu
authors.forename: Chuan-Ping
authors.initials: CP
authors.lastname: Zhang
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Niu
authors.forename: Wen-Zheng
authors.initials: WZ
authors.lastname: Pan
authors.forename: Xiao-Wei
authors.initials: XW
authors.lastname: Huang
authors.forename: Ke-Qin
authors.initials: KQ
authors.lastname: Zhang
mesh_terms: D002681:China; D004151:Dipeptides / Q000737:chemistry* / Q000302:isolation & purification*; D026121:Indole Alkaloids / Q000737:chemistry* / Q000302:isolation & purification*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000302:isolation & purification*; D032901:Talaromyces / Q000737:chemistry*
chemical_list: D004151:Dipeptides; D026121:Indole Alkaloids; D010456:Peptides, Cyclic; C569085:cyclo(glycyltryptophyl); C541224:notoamide E