title: Implication of haematophagous arthropod salivary proteins in host-vector interactions.
abstract: The saliva of haematophagous arthropods contains an array of anti-haemostatic, anti-inflammatory and immunomodulatory molecules that contribute to the success of the blood meal. The saliva of haematophagous arthropods is also involved in the transmission and the establishment of pathogens in the host and in allergic responses. This survey provides a comprehensive overview of the pharmacological activity and immunogenic properties of the main salivary proteins characterised in various haematophagous arthropod species. The potential biological and epidemiological applications of these immunogenic salivary molecules will be discussed with an emphasis on their use as biomarkers of exposure to haematophagous arthropod bites or vaccine candidates that are liable to improve host protection against vector-borne diseases.
authors.affiliation: Unité de Parasitologie - UMR6236 - IFR48, Antenne Marseille de l'Institut de Recherche Biomédicale des Armées (IRBA), Le Pharo, BP 60109, 13 262 Marseille Cedex 07, France.
authors.forename: Albin
authors.initials: A
authors.lastname: Fontaine
authors.forename: Ibrahima
authors.initials: I
authors.lastname: Diouf
authors.forename: Nawal
authors.initials: N
authors.lastname: Bakkali
authors.forename: Dorothée
authors.initials: D
authors.lastname: Missé
authors.forename: Frédéric
authors.initials: F
authors.lastname: Pagès
authors.forename: Thierry
authors.initials: T
authors.lastname: Fusai
authors.forename: Christophe
authors.initials: C
authors.lastname: Rogier
authors.forename: Lionel
authors.initials: L
authors.lastname: Almeras
mesh_terms: D000818:Animals; D060829:Arthropod Proteins / Q000276:immunology / Q000494:pharmacology; D001179:Arthropod Vectors / Q000737:chemistry / Q000276:immunology* / Q000502:physiology; D001181:Arthropods / Q000737:chemistry / Q000276:immunology* / Q000502:physiology; D001733:Bites and Stings / Q000097:blood* / Q000276:immunology* / Q000469:parasitology; D006487:Hemostasis; D006790:Host-Parasite Interactions; D006801:Humans; D012471:Salivary Proteins and Peptides / Q000276:immunology* / Q000494:pharmacology
chemical_list: D060829:Arthropod Proteins; D012471:Salivary Proteins and Peptides