title: [Effect of intranasal administration of dopamine on anxiety and locomotor activity of two lines of mice].
abstract: Intranasal administration of dopamine (0.3; 3 and 30 microg/kg) on anxious behaviour of mice was studied using elevated plus-maze and open fields tests and the pinch-induced catalepsy on parallel bars test. Dopamine was introduced as nose drops or inhalation of nanoparticles of the compound solution in C57B1/6J and CBA/Lac mice with differences of dopaminergic function features. In our experiment, dopamine had anxiolytic and elevated motor activity effects in C57B1/6J, but not in the CBA/Lac mice. Nose drops were more effective than inhalation; perhaps, it was a more stressful manipulation. Apparently dopamine increased the number of CBA/Lac mice who demonstrated catalepsy and the reflex duration. Indeed, the neurotransmitter is active in different psycho-emotional phenomena.
authors.forename: A V
authors.initials: AV
authors.lastname: Kholodar'
authors.forename: A V
authors.initials: AV
authors.lastname: Amikishieva
authors.forename: M P
authors.initials: MP
authors.lastname: Anisimov
mesh_terms: D000280:Administration, Inhalation; D000281:Administration, Intranasal; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001007:Anxiety / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D001008:Anxiety Disorders / Q000378:metabolism / Q000503:physiopathology; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D002375:Catalepsy / Q000378:metabolism / Q000503:physiopathology; D004298:Dopamine / Q000494:pharmacology*; D004304:Dosage Forms; D004305:Dose-Response Relationship, Drug; D004644:Emotions / Q000187:drug effects*; D008297:Male; D018782:Maze Learning / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D023421:Models, Animal; D009043:Motor Activity / Q000187:drug effects*; D053758:Nanoparticles / Q000008:administration & dosage; D013045:Species Specificity
chemical_list: D014151:Anti-Anxiety Agents; D004304:Dosage Forms; D004298:Dopamine