title: Quantification of retinal nerve fiber layer thickness after unilateral acute primary angle closure in Asian Indian eyes.
abstract: OBJECTIVE
  To determine retinal nerve fiber layer thickness (RNFLT) using Spectral optical coherence tomography/scanning laser ophthalmoscope (Spectral OCT/SLO) in Asian Indian eyes after single, unilateral attack of acute primary angle closure (APAC).
  
  
  METHODS
  Thirty-two patients with unilateral attack of APAC with normal optic disc and normal visual field, unaffected fellow eyes, and 35 age-matched normal control eyes were enrolled for the study. Six weeks after the remission of acute attack, peripapillary average, quadrant, and clock-hour RNFLT were compared between 3 groups using Spectral OCT/SLO.
  
  
  RESULTS
  APAC patients had mean IOP of 51.3±13.3 mm Hg (range, 40-74) at the time of presentation with acute attack in the affected eye and 14.9±2.9 mm Hg at 6 weeks after resolution of APAC. Duration of symptoms of acute attack was 35.9±23.8 hours. Significant differences were found between RNFLT in APAC and fellow eyes for most the parameters except for 1, 4, 6, and 7-o'clock-hour sector. Most of the RNFLT parameters showed statistically significant difference between APAC and normal control eyes except for temporal quadrant, 6, 7-o'clock-hour sectors. Statistically significant differences were found between RNFLT in unaffected fellow and normal control eyes for most of the parameters except for 6, 7, 11 o'clock-hour sectors.
  
  
  CONCLUSIONS
  RNFLT was found to be significantly thinner in APAC and unaffected fellow eyes when compared with normal age-matched controls. Hence, patients with APAC should be monitored carefully to determine its long-term effects on optic disc, RNFLT, and visual fields. Longitudinal studies can determine whether the RNFLT measurements remained stable or showed progression in these patients.
authors.affiliation: *Department of Glaucoma, Pushpagiri Eye Institute, Uma Plaza, West Marredpally, Secunderabad, Andhra Pradesh, India †Department of Biostatistics, National Institute of Nutrition, Hyderabad, Andhra Pradesh, India.
authors.forename: Tarannum
authors.initials: T
authors.lastname: Mansoori
authors.forename: Kalluri
authors.initials: K
authors.lastname: Viswanath
authors.forename: Nagalla
authors.initials: N
authors.lastname: Balakrishna
mesh_terms: D000208:Acute Disease; D000959:Antihypertensive Agents / Q000627:therapeutic use; D044466:Asian People / Q000208:ethnology; D003430:Cross-Sectional Studies; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000175:diagnosis* / Q000208:ethnology / Q000628:therapy; D006801:Humans; D007194:India / Q000453:epidemiology; D007429:Intraocular Pressure; D032801:Iridectomy; D053685:Laser Therapy; D053844:Lasers, Solid-State / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009887:Ophthalmoscopy; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis* / Q000208:ethnology / Q000628:therapy; D011446:Prospective Studies; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence; D058609:Visual Field Tests; D014794:Visual Fields
chemical_list: D000959:Antihypertensive Agents