title: Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples.
abstract: Genetic variants in ankyrin 3 (ANK3) have recently been shown to be associated with bipolar disorder (BD). We genotyped three ANK3 SNPs previously found to be associated with BD (rs10994336, rs1938526, and rs9804190) in a Scandinavian BD case-control sample (N = 854/2,614). Due to evidence of genetic overlap between BD and schizophrenia (SZ), we also genotyped these three SNPs in a Scandinavian SZ case-control sample (N = 1,073/2,919). Combining our Scandinavian samples with an Icelandic sample (N = 435 BD cases, 651 SZ cases, and 11,491 healthy controls), we found rs10994336 and rs9804190 to be nominally significantly associated with BD in this combined Nordic BD sample (N = 1,289/14,105). Nominal P was 0.015/0.018 (fixed/random effect) for rs10994336 (Bonferroni corrected P = 0.044/0.053) and 0.023 for rs9804190 (Bonferroni corrected P = 0.069). None of the SNPs were significantly associated with SZ in the combined Nordic SZ case-control sample (N = 1,724/14,410). These results further support that ANK3 is a susceptibility gene specific to BD and that more than one risk locus is involved.
authors.affiliation: Institute of Clinical Medicine, University of Oslo, Oslo, Norway. m.s.tesli@medisin.uio.no
authors.forename: Martin
authors.initials: M
authors.lastname: Tesli
authors.forename: Pernille
authors.initials: P
authors.lastname: Koefoed
authors.forename: Lavinia
authors.initials: L
authors.lastname: Athanasiu
authors.forename: Morten
authors.initials: M
authors.lastname: Mattingsdal
authors.forename: Omar
authors.initials: O
authors.lastname: Gustafsson
authors.forename: Ingrid
authors.initials: I
authors.lastname: Agartz
authors.forename: Lars M
authors.initials: LM
authors.lastname: Rimol
authors.forename: Andrew
authors.initials: A
authors.lastname: Brown
authors.forename: Katrine V
authors.initials: KV
authors.lastname: Wirgenes
authors.forename: Lisa-Lena
authors.initials: LL
authors.lastname: Smorr
authors.forename: Anna K
authors.initials: AK
authors.lastname: Kähler
authors.forename: Thomas
authors.initials: T
authors.lastname: Werge
authors.forename: Ole
authors.initials: O
authors.lastname: Mors
authors.forename: Erling
authors.initials: E
authors.lastname: Mellerup
authors.forename: Erik G
authors.initials: EG
authors.lastname: Jönsson
authors.forename: Ingrid
authors.initials: I
authors.lastname: Melle
authors.forename: Gunnar
authors.initials: G
authors.lastname: Morken
authors.forename: Srdjan
authors.initials: S
authors.lastname: Djurovic
authors.forename: Ole A
authors.initials: OA
authors.lastname: Andreassen
mesh_terms: D017487:Ankyrins / Q000235:genetics*; D001714:Bipolar Disorder / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007055:Iceland; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012537:Scandinavian and Nordic Countries; D012559:Schizophrenia / Q000235:genetics*
chemical_list: C490613:ANK3 protein, human; D017487:Ankyrins