title: Clinical outcome of acute intoxication due to ingestion of auxin-like herbicides.
abstract: BACKGROUND
  The human toxicity of synthetic auxin analogue herbicides has not been extensively studied.
  
  
  METHODS
  Clinical outcome was assessed from medical records of 17 patients who had intentionally ingested auxin pesticides with active ingredients like dicamba, triclopyr, MCPA or mecoprop. The patients were interviewed after discharge to follow outcome (interval 2 to 56 months).
  
  
  RESULTS
  One patient who had ingested 500 mL of a mecoprop product died of hypotension and respiratory failure 36 hours after hospital admission. The other 16 patients recovered and were discharged by hospital day 28. After discharge, four patients died from causes not related to herbicide intoxication. In the 12 surviving patients, no long-term effects were reported.
  
  
  CONCLUSIONS
  Human toxicity of synthetic auxins appears relatively benign with conservative treatment. However, when the amount ingested is above several hundred milliliters of commercial product, especially in combination of mecoprop with other intoxicants (e.g. alcohol), shock with respiratory failure may develop and lead to death.
authors.affiliation: Internal Medicine, Soonchunhyang University Cheonan Hospital, Republic of Korea.
authors.forename: Jae-Seok
authors.initials: JS
authors.lastname: Park
authors.forename: Su-Jin
authors.initials: SJ
authors.lastname: Seok
authors.forename: Hyo-Wook
authors.initials: HW
authors.lastname: Gil
authors.forename: Jong-Oh
authors.initials: JO
authors.lastname: Yang
authors.forename: Eun-Young
authors.initials: EY
authors.lastname: Lee
authors.forename: Yoon-Hyung
authors.initials: YH
authors.lastname: Park
authors.forename: Sae-Yong
authors.initials: SY
authors.lastname: Hong
mesh_terms: D008456:2-Methyl-4-chlorophenoxyacetic Acid / Q000031:analogs & derivatives / Q000506:poisoning / Q000633:toxicity; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003996:Dicamba / Q000506:poisoning; D005260:Female; D006016:Glycolates / Q000506:poisoning; D006540:Herbicides / Q000506:poisoning*; D006801:Humans; D007210:Indoleacetic Acids / Q000506:poisoning; D008297:Male; D008875:Middle Aged; D011041:Poisoning / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D006016:Glycolates; D006540:Herbicides; D007210:Indoleacetic Acids; C008340:mecoprop; D008456:2-Methyl-4-chlorophenoxyacetic Acid; C032742:triclopyr; D003996:Dicamba