title: Protein kinase C-theta in platelet activation.
abstract: Members of the protein kinase C (PKC) family of serine/threonine kinases have been implicated in several physiological processes regulating the activation response of platelets. They are involved in processes leading to granule secretion, integrin activation, platelet aggregation and spreading, and procoagulation. The protein kinase C θ (PKCθ) isoform, which was originally identified in T lymphocytes, is also expressed at relatively high levels in platelets, wherein it is involved in the regulation of hemostasis and thrombosis. Recent studies suggest a role for PKCθ in protease-activated receptor (PAR)-, glycoprotein VI (GPVI) receptor- and glycoprotein α(IIb)β(3) integrin receptor-linked signal transduction pathways. The present review focuses on the latest observations relevant to the role of PKCθ in platelet activation.
authors.affiliation: The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences and the Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva, Israel.
authors.forename: Sagit
authors.initials: S
authors.lastname: Cohen
authors.forename: Alex
authors.initials: A
authors.lastname: Braiman
authors.forename: George
authors.initials: G
authors.lastname: Shubinsky
authors.forename: Noah
authors.initials: N
authors.lastname: Isakov
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000201:enzymology*; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology; D006487:Hemostasis / Q000502:physiology; D006801:Humans; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism*; D010974:Platelet Aggregation / Q000502:physiology*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000235:genetics / Q000378:metabolism; D011493:Protein Kinase C / Q000235:genetics / Q000378:metabolism*; D000074121:Protein Kinase C-theta; D018179:Receptors, Thrombin / Q000235:genetics / Q000378:metabolism; D022142:Secretory Vesicles / Q000201:enzymology / Q000235:genetics; D015398:Signal Transduction / Q000502:physiology; D013601:T-Lymphocytes / Q000201:enzymology; D013927:Thrombosis / Q000201:enzymology / Q000235:genetics
chemical_list: D007527:Isoenzymes; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D018179:Receptors, Thrombin; C076233:PRKCQ protein, human; D011493:Protein Kinase C; D000074121:Protein Kinase C-theta