title: The regenerating gene iα is overexpressed in atrophic gastritis rats with hypergastrinemia.
abstract: The role of gastrin on the development of atrophic gastritis (AG) and its relationship with the expression of RegIα  in vivo remain unclear. We established experimental AG in rats by combination administration with sodium salicylate, alcohol, and deoxycholate sodium. The mean score of inflammation in gastric antrum in AG rats was significantly elevated (P < 0.05), while the number of glands dramatically decreased (P < 0.05). In addition, the cell proliferation in gastric glands was increased in experimental AG rats, as determined by immunohistochemistry staining of PCNA and GS II. The level of serum gastrin in AG rats was significantly elevated relative to that of normal rats (P < 0.01). Moreover, the expression of RegIα protein and its receptor mRNA was increased in gastric tissues in AG rats (P < 0.05). Taken together, we demonstrated that the overexpression of Reglα is related with hypergastrinemia in AG rats.
authors.affiliation: Laboratory of Digestive Disease, Sir Run Run Shaw Clinical Medicine Institution of Zhejiang University, Hangzhou 310003, China.
authors.forename: Shujie
authors.initials: S
authors.lastname: Chen
authors.forename: Jing
authors.initials: J
authors.lastname: Zhong
authors.forename: Qunyan
authors.initials: Q
authors.lastname: Zhou
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Lu
authors.forename: Liangjing
authors.initials: L
authors.lastname: Wang
authors.forename: Jianmin
authors.initials: J
authors.lastname: Si