title: [Ocular changes after hormone replacement therapy in postmenopausal women. A preliminary report].
abstract: BACKGROUND
  Ocular function is modified with hormone therapy; however, reports in literature are highly controversial.
  
  
  OBJECTIVE
  To analyze how hormone therapy modifies intraocular pressure and the number of tears shed by Mexican women.
  
  
  METHODS
  Eighteen postmenopausal women were studied and randomly divided into two groups, according to the treatment they received: group 1, conjugated equine estrogens (CEE) 0.625 mg/day (n=9) (hysterectomized women with bilateral oophorectomy) and group 2, CEE 0.625 mg/day plus chlormadinone 1 mg/day (n=9) (women with intact uterus). Changes in intraocular pressure and Schirmer's test were analyzed at baseline and three months after the treatment. Statistical analysis was performed with Student's t test for independent and paired samples.
  
  
  RESULTS
  There were no significant differences in intraocular pressure or Schirmer's test among groups, neither when comparing baseline and final results in each group independently.
  
  
  CONCLUSIONS
  We could not demonstrate the effect of hormone replacement therapy on intraocular pressure and on Schirmer's test after three months of its administration.
authors.affiliation: Departamento de Ginecología Endocrina, Hospital de Ginecología y Obstetricia Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, México, DF. scarranzal@mexis.com
authors.forename: Sebastián
authors.initials: S
authors.lastname: Carranza Lira
authors.forename: Alicia M
authors.initials: AM
authors.lastname: Jiménez
authors.forename: Irene
authors.initials: I
authors.lastname: Olhovich
mesh_terms: D002715:Chlormadinone Acetate / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004966:Estrogens, Conjugated (USP) / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D007044:Hysterectomy; D007429:Intraocular Pressure / Q000187:drug effects*; D008875:Middle Aged; D010052:Ovariectomy; D017698:Postmenopause; D012636:Secretory Rate / Q000187:drug effects; D013666:Tears / Q000378:metabolism*
chemical_list: D004966:Estrogens, Conjugated (USP); D002715:Chlormadinone Acetate