title: Antimicrobial activities of sesquiterpene lactones and inositol derivatives from Hymenoxys robusta.
abstract: Six compounds from the aerial parts of the Argentinean plant Hymenoxys robusta (Rusby) Parker were isolated and their structures elucidated using extensive spectroscopic analyses. These compounds comprise two inositol derivatives and four 3,4-seco-pseudoguaianolides, including vermeerin. Bioactivity assays of these compounds against bacterial and fungal pathogens showed that only vermeerin possessed antimicrobial activity specific against Staphylococcus aureus, and showed no toxicity when exposed to human-derived macrophages.
authors.affiliation: Facultad de Agronomía y Zootecnia, Universidad Nacional de Tucumán, San Miguel de Tucumán, Argentina.
authors.forename: Antonio M
authors.initials: AM
authors.lastname: Fortuna
authors.forename: Zaida N
authors.initials: ZN
authors.lastname: Juárez
authors.forename: Horacio
authors.initials: H
authors.lastname: Bach
authors.forename: Anouf
authors.initials: A
authors.lastname: Nematallah
authors.forename: Yossef
authors.initials: Y
authors.lastname: Av-Gay
authors.forename: Eugenio
authors.initials: E
authors.lastname: Sánchez-Arreola
authors.forename: C A N
authors.initials: CA
authors.lastname: Catalán
authors.forename: S
authors.initials: S
authors.lastname: Turbay
authors.forename: Luis R
authors.initials: LR
authors.lastname: Hernández
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001234:Aspergillus niger / Q000187:drug effects; D019659:Asteraceae / Q000737:chemistry*; D002176:Candida albicans / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007294:Inositol / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D014249:Trichophyton / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D007783:Lactones; D012717:Sesquiterpenes; D007294:Inositol