title: [Follow-up study on refractory schizophrenia  with brain stereotaxis therapy].
abstract: OBJECTIVE
  To determine the long-term effect and security of refractory schizophrenia with brain stereotaxis multi-target therapy technique.
  
  
  METHODS
  A total of 87 patients with refractory schizophrenia were treated with brain stereotaxis multi-target therapy and were followed up over 2 years. The scores of Clinical Global Impression, Brief Psychiatric Rating Scale, Positive and Negative Symptom Scale, Wechsler Adult Intelligence Scale, Wechsler Memory Scale, Actives of Daily Living, and Social Disability Screening Schedule were compared before and after the operation.
  
  
  RESULTS
  Of the 87 patients, 40 obviously improved, 24 improved, 12 improved little, 7 did not change. None grew worse, 1 died, and 3 shed. There was a significant difference in the scales before and after the operation (P<0.01). No severe complications and sequelae occurred.
  
  
  CONCLUSIONS
  Stereotaxic multi-target therapy is effective and safe for refractory schizophrenia. After the operation, drug therapy should be maintained and recovery of social function is helpful.
authors.affiliation: Department of Functional Neurosurgery, Brains Hospital of Hunan Province, Changsha, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Cai
authors.forename: Weiping
authors.initials: W
authors.lastname: Kuang
authors.forename: Tiansheng
authors.initials: T
authors.lastname: Guo
authors.forename: Hongxing
authors.initials: H
authors.lastname: Huang
authors.forename: Zhimei
authors.initials: Z
authors.lastname: Wu
authors.forename: Bin
authors.initials: B
authors.lastname: Zhou
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhu
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Chen
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: Hongxian
authors.initials: H
authors.lastname: Chen
mesh_terms: D000328:Adult; D001921:Brain / Q000601:surgery*; D010054:Brief Psychiatric Rating Scale; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000601:surgery*; D013238:Stereotaxic Techniques; D055815:Young Adult