title: Spectral optical coherence tomography in a patient with type I sialidosis.
abstract: BACKGROUND
  The aim of our study was to analyze spectral optical coherence tomography (SD-OCT) findings in a patient with clinical signs of sialidosis.
  
  
  METHODS
  Fluorescein angiography and spectral optical coherence tomography was performed in a 37-year-old woman using a SD-OCT device with axial resolution of 6 µm. Enzyme assay followed. The patient was diagnosed with type I sialidosis by enzymatic assay. Besides a normal angiogram, a thickened nerve fiber layer was observed on spectral optical coherence tomography.
  
  
  CONCLUSIONS
  The thickened nerve fiber layer was probably caused by accumulation of metabolic products such as sialylated oligosaccharides and glycopeptides, suggesting that SD- OCT, due to its enhanced resolution, can be a useful tool for diagnosis of rare neurological conditions.
authors.affiliation: Ophthalmic Clinic Jasne Blonia, Lodz, Poland. zosia_n@yahoo.com
authors.forename: Zofia
authors.initials: Z
authors.lastname: Michalewska
authors.forename: Agata
authors.initials: A
authors.lastname: Gajos
authors.forename: Janusz
authors.initials: J
authors.lastname: Michalewski
authors.forename: Jerzy
authors.initials: J
authors.lastname: Nawrocki
authors.forename: Alexey V
authors.initials: AV
authors.lastname: Pshezhetsky
authors.forename: Andrzej
authors.initials: A
authors.lastname: Bogucki
mesh_terms: D000328:Adult; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D009081:Mucolipidoses / Q000097:blood / Q000175:diagnosis* / Q000473:pathology*; D009439:Neuraminidase / Q000097:blood*; D012160:Retina / Q000473:pathology*; D013050:Spectrometry, Fluorescence; D041623:Tomography, Optical Coherence / Q000379:methods*
chemical_list: D009439:Neuraminidase