title: Photodegradation of hexythiazox in different solvent systems under the influence of ultraviolet light and sunlight in the presence of TiO2, H2O2, and KNO3 and identification of the photometabolites.
abstract: The photodegradation of the carboxamide acaricide hexythiazox in three different solvent systems (aqueous methanolic, aqueous isopropanolic, and aqueous acetonitrilic solutions) in the presence of H(2)O(2), KNO(3), and TiO(2) under ultraviolet (UV) light (λ(max) ≥ 250 nm) and sunlight (λ(max) ≥290 nm) has been assessed in this work. The kinetics of photodecomposition of hexythiazox and the identification of photoproducts were carried out using liquid chromatography-mass spectrometry. The rate of photodecomposition of hexythiazox in different solvents followed first-order kinetics in both UV radiation and natural sunlight, and the degradation rates were faster under UV light than under sunlight. Hexythiazox was found to be more efficiently photodegraded in the presence of TiO(2) than in the presence of H(2)O(2) and KNO(3). Two major photoproducts were separated in pure form using column chromatography and identified according to IR, (1)H NMR, and mass spectral information as cyclohexylamine and 5-(4-chlorophenyl)-4-methylthiazolidin-2-one. Another nine photoproducts were identified according to LC-MS/MS spectral information. The plausible photodegradation pathways of hexythiazox were proposed according to the structures of the photoproducts.
authors.affiliation: Department of Chemistry, Kalyani University, Kalyani 741235, West Bengal, India.
authors.forename: Sudeb
authors.initials: S
authors.lastname: Mandal
authors.forename: Soumen
authors.initials: S
authors.lastname: Joardar
authors.forename: Saktipada
authors.initials: S
authors.lastname: Das
authors.forename: Anjan
authors.initials: A
authors.lastname: Bhattacharyya
mesh_terms: D056810:Acaricides / Q000737:chemistry*; D004355:Drug Stability; D006861:Hydrogen Peroxide / Q000737:chemistry; D007700:Kinetics; D009566:Nitrates / Q000737:chemistry; D010782:Photolysis / Q000528:radiation effects*; D017680:Potassium Compounds / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D014025:Titanium / Q000737:chemistry; D014466:Ultraviolet Rays
chemical_list: D056810:Acaricides; D009566:Nitrates; D017680:Potassium Compounds; D012997:Solvents; C009495:titanium dioxide; D006861:Hydrogen Peroxide; D014025:Titanium; C023844:potassium nitrate