title: Histopathological and immunohistochemical study on the effects of a direct pulp capping experimentally developed adhesive resin system containing reparative dentin-promoting agents.
abstract: The studies so far conducted by our colleagues in relation to dental pulp capping using adhesive resins revealed that the adhesive resins are useful for capping exposed pulps but are a little slower to take effect on the injured pulp tissue during the initial stage: up to 90-days after pulp exposure, compared with calcium hydroxide and its preparations. In the present study, an experimentally developed adhesive resin system was applied in direct pulp capping and restoration and the healing process was examined histopathologically and immunohistochemically. The resin system was manufactured with calcium phosphate added into the bonding material for the purpose of accelerating the healing process. The largest amount of reparative dentin was formed by SE5 (whitlockite 5 wt%), followed by SE9 (hydroxyapatite 5 wt%, whitlockite 5 wt%), SE1 (hydroxyapatite 5 wt%), and SE2 (hydroxyapatite 10 wt%). Generally, it could be said that the experimental groups using whitlockite and hydroxyapatite had the tendency to produce a larger amount of reparative dentin.
authors.affiliation: Advanced Operative Dentistry-Endodontics, Graduate School of Life Dentistry at Niigata, The Nippon Dental University, 1-8 Hamaura-cho, Chuo-ku, Niigata 951-8580, Japan. chigeru1514@yahoo.co.jp
authors.forename: Chikage
authors.initials: C
authors.lastname: Kato
authors.forename: Masaya
authors.initials: M
authors.lastname: Suzuki
authors.forename: Koichi
authors.initials: K
authors.lastname: Shinkai
authors.forename: Yoshiroh
authors.initials: Y
authors.lastname: Katoh
mesh_terms: D000636:Aminosalicylic Acids / Q000627:therapeutic use; D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use; D002126:Calcium Hydroxide / Q000627:therapeutic use; D002130:Calcium Phosphates / Q000627:therapeutic use; D004396:Coloring Agents; D003782:Dental Pulp / Q000187:drug effects / Q000382:microbiology / Q000473:pathology; D003785:Dental Pulp Capping / Q000379:methods*; D003789:Dental Pulp Exposure / Q000628:therapy; D003790:Dental Pulp Necrosis / Q000473:pathology; D003793:Dental Restoration, Permanent; D003809:Dentin, Secondary / Q000187:drug effects*; D017886:Durapatite / Q000627:therapeutic use; D007150:Immunohistochemistry; D008297:Male; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry / Q000627:therapeutic use; D008903:Minerals / Q000627:therapeutic use; D057872:Pulp Capping and Pulpectomy Agents / Q000627:therapeutic use*; D011671:Pulpitis / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D019279:Resin Cements / Q000737:chemistry*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000636:Aminosalicylic Acids; D001672:Biocompatible Materials; D002130:Calcium Phosphates; C112828:Clearfil AP-X; C438313:Clearfil SE Bond; D004396:Coloring Agents; D008689:Methacrylates; D008903:Minerals; D057872:Pulp Capping and Pulpectomy Agents; D019279:Resin Cements; C485817:beta-tricalcium phosphate; C022045:octacalcium phosphate; C074497:N-methacryloyl-5-aminosalicylic acid; C025702:Dycal; D017886:Durapatite; C494366:calcium phosphate, dibasic, dihydrate; D002126:Calcium Hydroxide