title: Association between Helicobacter pylori infection and laryngeal squamous cell carcinoma in a Chinese male population.
abstract: OBJECTIVE
  To investigate the presence of Helicobacter pylori in the larynx, and to identify the relationship between H. pylori infection and laryngeal squamous cell carcinoma in a male population.
  
  
  METHODS
  This study included 59 male patients with laryngeal squamous cell carcinoma and 41 control subjects. Nested polymerase chain reaction and target fragment sequencing were used to detect the presence of H. pylori in laryngeal mucosa. Logistic regression analysis was used to assess the association between H. pylori infection and laryngeal cancer.
  
  
  RESULTS
  H. pylori was present in a significantly greater number of patients with laryngeal carcinoma (76.3%) than in control subjects (31.7%) (p < 0.001). The correlation between H. pylori infection and laryngeal cancer was highly significant (OR = 9.82, 95% CI [3.35, 28.80], p < 0.001).
  
  
  CONCLUSIONS
  The present study shows that H. pylori is present in the laryngeal mucosa of men, and supports a possible relationship between H. pylori infection and laryngeal squamous cell carcinoma in a male population.
authors.affiliation: Department of Clinical Laboratory, Fudan University, Shanghai, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Shi
authors.forename: Hongli
authors.initials: H
authors.lastname: Gong
authors.forename: Liang
authors.initials: L
authors.lastname: Zhou
authors.forename: Lei
authors.initials: L
authors.lastname: Tao
authors.forename: Yong
authors.initials: Y
authors.lastname: Shi
authors.forename: Wenjun
authors.initials: W
authors.lastname: Cao
authors.forename: Lei
authors.initials: L
authors.lastname: Cheng
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000208:ethnology; D044466:Asian People / Q000706:statistics & numerical data*; D002294:Carcinoma, Squamous Cell / Q000208:ethnology* / Q000382:microbiology / Q000473:pathology; D002681:China / Q000453:epidemiology; D016481:Helicobacter Infections / Q000208:ethnology*; D016480:Helicobacter pylori / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000208:ethnology* / Q000382:microbiology / Q000473:pathology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000382:microbiology; D009367:Neoplasm Staging / Q000706:statistics & numerical data; D016133:Polymerase Chain Reaction; D012307:Risk Factors; D012907:Smoking / Q000208:ethnology; D055815:Young Adult