title: Protective effect of Polyalthia longifolia var. pendula leaves on ethanol and ethanol/HCl induced ulcer in rats and its antimicrobial potency.
abstract: OBJECTIVE
  To explore antiulcer and antimicrobial properties of methanolic extract of Polyalthia longifolia var. pendula.
  
  
  METHODS
  Gastroprotective potential of Polyalthia longifolia was studied on ethanol and ethanol/HCl induced ulcers at 2 different doses (270 and 540 mg/kg/body weight). Antimicrobial efficacy of Polyalthia longifolia (25 mg/mL) was also studied against six gram positive, seven gram negative bacteria and five fungi by agar well diffusion method. Minimum inhibitory concentration was determined by agar well diffusion method in two fold serial dilution, in the range of 97-25,000 μg/mL.
  
  
  RESULTS
  The reduction of ulcer index in Polyalthia longifolia treated animals was found to be statistically significant with respect to control animals. The Polyalthia longifolia exhibited ulcer protection activity in dose dependent manner and was also better than the standard. In antimicrobial activity, gram positive bacteria were more susceptible to Polyalthia longifolia than gram negative bacteria and fungal strains.
  
  
  CONCLUSIONS
  Results obtained confirm the antiulcer and antimicrobial potential of the Polyalthia longifolia.
authors.affiliation: Phytochemical, Pharmacological and Microbiological Laboratory, Department of Biosciences, Saurashtra University, Gujarat, India. svchanda@gmail.com
authors.forename: Sumitra
authors.initials: S
authors.lastname: Chanda
authors.forename: Yogesh
authors.initials: Y
authors.lastname: Baravalia
authors.forename: Mital
authors.initials: M
authors.lastname: Kaneria
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000890:Anti-Infective Agents; D001419:Bacteria / Q000187:drug effects; D004195:Disease Models, Animal; D000431:Ethanol / Q000009:adverse effects; D005260:Female; D005658:Fungi / Q000187:drug effects; D006801:Humans; D006851:Hydrochloric Acid / Q000009:adverse effects; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage*; D018515:Plant Leaves / Q000737:chemistry*; D031044:Polyalthia / Q000737:chemistry*; D020011:Protective Agents / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D014456:Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D010936:Plant Extracts; D020011:Protective Agents; D000431:Ethanol; D006851:Hydrochloric Acid