title: Overview of pharmacokinetics.
abstract: In addition to having potency against the molecular target, a compound must be able to reach its intended site of action in vivo in sufficient quantity and for the appropriate duration to exert a biological effect. The fate of a compound after in vivo administration depends upon the absorption, distribution, metabolism, and excretion (ADME) of the compound, and the concentration of the compound in the blood, plasma, or other tissues represents the sum of all of these processes. Described in this unit are protocols for administering a compound by a variety of routes and for collecting the appropriate samples to determine the pharmacokinetic profile. The basic terms used in pharmacokinetic studies are defined, and representative examples are given to illustrate important variables to consider.
authors.affiliation: Cephalon Inc., West Chester, Pennsylvania, USA.
authors.forename: Lisa D
authors.initials: LD
authors.lastname: Aimone
mesh_terms: D000818:Animals; D003627:Data Interpretation, Statistical; D005260:Female; D008297:Male; D010599:Pharmacokinetics; D051381:Rats; D013048:Specimen Handling