title: Food allergy: mechanisms and therapeutics.
abstract: The immunologic mechanisms responsible for the development of allergic sensitization rather than tolerance to foods are not well understood, although there have been a number of recent advances in our understanding of why some foods are inherently allergenic. In addition, the involvement of alternative routes of exposure that are not inherently tolerogenic may play a role in sensitization to foods. Although there are no currently accepted therapeutic approaches to food allergy, there are a number of approaches to treatment in preclinical or clinical trials. Here, we review selected findings published since 2009 that advance our understanding of mechanisms and new therapeutics for IgE-mediated food allergy.
authors.affiliation: Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA.
authors.forename: M Cecilia
authors.initials: MC
authors.lastname: Berin
authors.forename: Scott
authors.initials: S
authors.lastname: Sicherer
mesh_terms: D000707:Anaphylaxis / Q000276:immunology; D000818:Animals; D005512:Food Hypersensitivity / Q000276:immunology* / Q000628:therapy*; D006801:Humans; D007108:Immune Tolerance; D007113:Immunity, Innate; D007073:Immunoglobulin E / Q000276:immunology
chemical_list: D007073:Immunoglobulin E