title: Genetic variation of 15 autosomal microsatellite loci in a Nayarit population (Mexico).
abstract: Fifteen STRs are studied to determine the allele frequencies' distribution and to evaluate the homogeneity of Nayarit populations. This study allows the identification of forensic efficiency parameters to be used in forensic genetics and to explore the genetic similarities between Nayarit and the neighboring countries such as Mexico, Brazil, Puerto Rico, Guatemala, Honduras, Bolivia and Costa Rica. The Hardy-Weinberg equilibrium, expected heterozygosity, matching probability, and power of discrimination, were calculated in the Nayarit population. We found that with respect to the studied markers, Nayarit genetic structure is homogeneous. In this study, it is established that Nayarit is genetically similar to the South American Mestizo population. The distribution of a set of these 15 STRs was analyzed with other South American populations as well as in the extensive set of neighboring populations from the literature (USA, Europe and Africa). We found significant differences exist between the isolated populations (Huastecos, Otomi from Sierra Madre and from Ixmiquilpan Valley) and Mestizo populations. Statistical analysis supports that Americans actual inhabitants and Europeans are genetically similar, while Africans and isolated populations from South America have more genetic differences.
authors.affiliation: Laboratory of Genetic Identification, Department of Legal Medicine, University of Granada, Granada, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Alvarez-Cubero
authors.forename: L J
authors.initials: LJ
authors.lastname: Martinez-Gonzalez
authors.forename: D
authors.initials: D
authors.lastname: Virgen-Ponce
authors.forename: E A
authors.initials: EA
authors.lastname: Delgado-Najar
authors.forename: G H
authors.initials: GH
authors.lastname: Moscoso-Caloca
authors.forename: J C
authors.initials: JC
authors.lastname: Alvarez
authors.forename: J A
authors.initials: JA
authors.lastname: Lorente
mesh_terms: D030541:Databases, Genetic; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics*; D005828:Genetics, Population; D006801:Humans; D008800:Mexico / Q000208:ethnology; D018895:Microsatellite Repeats / Q000235:genetics*; D008962:Models, Theoretical; D016133:Polymerase Chain Reaction