title: Quantum dots and carbon nanotubes in oncology: a review on emerging theranostic applications in nanomedicine.
abstract: Cancer is one of the main causes of death in the world, and according to the WHO it is projected to continue rising. Current diagnostic modalities for the detection of cancer include the use of x-rays, magnetic resonance imaging and positron emission tomography, among others. The treatment of cancer often involves the use (or combination) of chemotherapeutic drugs, radiotherapy and interventional surgery (for solid and operable tumors). The application of nanotechnology in biology and medicine is advancing rapidly. Recent evidence suggests that quantum dots (QDs) can be used to image cancer cells as they display superior fluorescent properties compared with conventional chromophores and contrast agents. In addition, carbon nanotubes (CNTs) have emerged as viable candidates for novel chemotherapeutic drug delivery-platforms. The unique photothermal properties of CNTs also allow them to be used in conjunction with near infrared radiation and lasers to thermally ablate cancer cells. Furthermore, mounting evidence indicates that it is possible to conjugate QDs to CNTs, making it possible to exploit their novel attributes in the realm of cancer theranostics (diagnostics and therapy). Here we review the current literature pertaining to the applications of QDs and CNTs in oncology, and also discuss the relevance and implications of nanomedicine in a clinical setting.
authors.affiliation: Centre for Nanotechnology & Regenerative Medicine, UCL Division of Surgery & Interventional Science, University College London, London, UK.
authors.forename: Aaron
authors.initials: A
authors.lastname: Tan
authors.forename: Lara
authors.initials: L
authors.lastname: Yildirimer
authors.forename: Jayakumar
authors.initials: J
authors.lastname: Rajadas
authors.forename: Hugo
authors.initials: H
authors.lastname: De La Peña
authors.forename: Giorgia
authors.initials: G
authors.lastname: Pastorin
authors.forename: Alexander
authors.initials: A
authors.lastname: Seifalian
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D050997:Nanomedicine / Q000379:methods*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy; D045663:Quantum Dots
chemical_list: D000970:Antineoplastic Agents; D037742:Nanotubes, Carbon