title: Association of SNCA with Parkinson: replication in the Harvard NeuroDiscovery Center Biomarker Study.
abstract: BACKGROUND
  Mutations in the α-synuclein gene (SNCA) cause autosomal dominant forms of Parkinson's disease, but the substantial risk conferred by this locus to the common sporadic disease has only recently emerged from genome-wide association studies.
  
  
  METHODS
  We genotyped a prioritized noncoding variant in SNCA intron 4 in 344 patients with Parkinson's disease and 275 controls from the longitudinal Harvard NeuroDiscovery Center Biomarker Study.
  
  
  RESULTS
  The common minor allele of rs2736990 was associated with elevated disease susceptibility (odds ratio, 1.40; P = .0032).
  
  
  CONCLUSIONS
  This result increases confidence in the notion that in many clinically well-characterized patients, genetic variation in SNCA contributes to "sporadic" disease.
authors.affiliation: Center for Neurologic Diseases, Harvard Medical School and Brigham & Women's Hospital, Cambridge, Massachusetts, USA.
authors.forename: Hongliu
authors.initials: H
authors.lastname: Ding
authors.forename: Alison K
authors.initials: AK
authors.lastname: Sarokhan
authors.forename: Sarah S
authors.initials: SS
authors.lastname: Roderick
authors.forename: Rachit
authors.initials: R
authors.lastname: Bakshi
authors.forename: Nancy E
authors.initials: NE
authors.lastname: Maher
authors.forename: Paymon
authors.initials: P
authors.lastname: Ashourian
authors.forename: Caroline G
authors.initials: CG
authors.lastname: Kan
authors.forename: Sunny
authors.initials: S
authors.lastname: Chang
authors.forename: Andrea
authors.initials: A
authors.lastname: Santarlasci
authors.forename: Kyleen E
authors.initials: KE
authors.lastname: Swords
authors.forename: Bernard M
authors.initials: BM
authors.lastname: Ravina
authors.forename: Michael T
authors.initials: MT
authors.lastname: Hayes
authors.forename: U Shivraj
authors.initials: US
authors.lastname: Sohur
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Wills
authors.forename: Alice W
authors.initials: AW
authors.lastname: Flaherty
authors.forename: Vivek K
authors.initials: VK
authors.lastname: Unni
authors.forename: Albert Y
authors.initials: AY
authors.lastname: Hung
authors.forename: Dennis J
authors.initials: DJ
authors.lastname: Selkoe
authors.forename: Michael A
authors.initials: MA
authors.lastname: Schwarzschild
authors.forename: Michael G
authors.initials: MG
authors.lastname: Schlossmacher
authors.forename: Lewis R
authors.initials: LR
authors.lastname: Sudarsky
authors.forename: John H
authors.initials: JH
authors.lastname: Growdon
authors.forename: Adrian J
authors.initials: AJ
authors.lastname: Ivinson
authors.forename: Bradley T
authors.initials: BT
authors.lastname: Hyman
authors.forename: Clemens R
authors.initials: CR
authors.lastname: Scherzer
mesh_terms: D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D006801:Humans; D007438:Introns / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D051844:alpha-Synuclein / Q000235:genetics*
chemical_list: D051844:alpha-Synuclein