title: [Oxytocin and syndrome of inappropriate secretion of antidiuretic neonatal hormone. Case report of early severe hyponatremia and literature review].
abstract: This is a clinical case presentation of a full term newborn infant who suffered severe hyponatremia and early seizures, associated with maternal fluid overload with electrolyte free solutions and high doses of oxytocin for labor augmentation. Although this condition has been recognized since the 1960's with isolated reports, this particular case has features that needs further investigation, not only for the unsually severe hyponatremia, but most importantly we think, for the prominent signs of fluid retention, the infant had, that suggest excessive antidiuretic activity probably due to oxytocin. These findings are consistent with syndrome of inappropriate secretion of antidiuretic hormone. Although until now there is no proof that oxytocin by itself produces this syndrome. We think the association is possible in certain clinical circumstances, such as those found in this case. We also, briefly discussed the pathophysiology of perinatal hyponatremia, the neonatal treatment of this condition and the current guidelines for the women in labor. Hyponatremia should not be considered a benign condition, since in the neonate, it may affect brain function.
authors.affiliation: Departamento de Neonatología, Hospital Materno Infantil de León, Guanajauto. caldnfp@prodigy.net.mx
authors.forename: Carlos
authors.initials: C
authors.lastname: Aldana-Valenzuela
authors.forename: José Alfredo
authors.initials: JA
authors.lastname: Prieto-Pantoja
authors.forename: Angélica
authors.initials: A
authors.lastname: Hernández-Acevedo
mesh_terms: D002585:Cesarean Section; D004829:Epilepsy, Generalized / Q000151:congenital* / Q000209:etiology / Q000503:physiopathology; D005260:Female; D005440:Fluid Therapy / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D007010:Hyponatremia / Q000151:congenital* / Q000209:etiology / Q000503:physiopathology; D007177:Inappropriate ADH Syndrome / Q000151:congenital* / Q000209:etiology / Q000503:physiopathology; D007231:Infant, Newborn; D007751:Labor, Induced / Q000379:methods; D008431:Maternal-Fetal Exchange; D009846:Oliguria / Q000151:congenital / Q000209:etiology; D010120:Oxytocics / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000494:pharmacology; D010121:Oxytocin / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000494:pharmacology; D011247:Pregnancy; D013943:Thymol / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D014869:Water Intoxication / Q000151:congenital* / Q000209:etiology / Q000503:physiopathology; D055815:Young Adult
chemical_list: C007905:Hartman's solution; D010120:Oxytocics; D013943:Thymol; D010121:Oxytocin