title: [The influence of morphogene Wg on the formation of an ectopic eye in Drosophila melanogaster].
abstract: Due to the ectopic expression of the ey gene in the wing imaginal disc under the action of the 1096-Gal4 driver, a part of the wing disc cells change their fate and become eye cells. Ectopic eyes are induced in definite regions of the wing disc and form a stable pattern on the wing of an adult fly. Here, we have shown that the ectopic expression of Wg inhibits the formation of ectopic eyes, and conversely the expression of Wg is reduced in the sites of ectopic Ey expression. Experiments with overexpression of the vesicular traffic protein H rs capable of inhibiting the Wg signaling agree with the notion on antagonism of Wg and Ey in ectopic eyes. Our results confirm that the processes of formation of normal and ectopic eyes are principally similar with regard to genetic control.
authors.forename: S A
authors.initials: SA
authors.lastname: Kopyl
authors.forename: T D
authors.initials: TD
authors.lastname: Dubatolova
authors.forename: E I
authors.initials: EI
authors.lastname: Volkova
authors.forename: E V
authors.initials: EV
authors.lastname: Marilovtseva
authors.forename: L V
authors.initials: LV
authors.lastname: Omel'ianchuk
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics; D029721:Drosophila Proteins / Q000096:biosynthesis* / Q000235:genetics; D004331:Drosophila melanogaster; D056827:Endosomal Sorting Complexes Required for Transport / Q000096:biosynthesis / Q000235:genetics; D005123:Eye / Q000166:cytology / Q000196:embryology*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D010750:Phosphoproteins / Q000096:biosynthesis / Q000235:genetics; D015398:Signal Transduction / Q000502:physiology*; D014921:Wings, Animal / Q000166:cytology / Q000196:embryology; D051155:Wnt1 Protein / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D056827:Endosomal Sorting Complexes Required for Transport; D010750:Phosphoproteins; D051155:Wnt1 Protein; C113278:ey protein, Drosophila; C096164:hepatocyte growth factor-regulated tyrosine kinase substrate; C074622:wg protein, Drosophila