title: Physical exercise improves cardiac autonomic modulation in hypertensive patients independently of angiotensin-converting enzyme inhibitor treatment.
abstract: We investigated the influence of angiotensin-converting enzyme inhibitor (ACEi) treatment and physical exercise on arterial pressure (AP) and heart rate variability (HRV) in volunteer patients with hypertension. A total of 54 sedentary volunteers were divided into three groups: normotensive (NT Group), hypertensive (HT Group) and HT volunteers treated with ACEi (ACEi Group). All volunteers underwent an aerobic physical-training protocol for 15 weeks. HRV was investigated using a spectral analysis of a time series of R-R interval (RRi) that was obtained in a supine position and during a tilt test. Physical training promoted a significant reduction in the mean arterial pressure of the HT group (113±3 vs. 106±1 mm Hg) and the ACEi group (104±2 vs. 98±2 mm Hg). Spectral analysis of RRi in the supine position before physical training demonstrated that the NT and ACEi groups had similar values at low frequency (LF; 0.04-0.15 Hz) and high frequency (HF; 0.15-0.5 Hz) oscillations. The HT group had an increase in LF oscillations in absolute and normalized units and a decrease in HF oscillations in normalized units compared with the other groups. The HT group had the lowest responses to the tilt test during LF oscillations in normalized units. Physical training improved the autonomic modulation of the heart rate in the supine position only in the HT group. Physical training promoted a similar increase in autonomic modulation responses in the tilt test in all groups. Our findings show that aerobic physical training improves cardiac autonomic modulation in HT volunteers independently of ACEi treatment.
authors.affiliation: Exercise Physiology Laboratory, Department of Biomechanics, Medicine and Rehabilitation, School of Medicine, University of São Paulo, Ribeirão Preto, Brazil.
authors.forename: Izabela C
authors.initials: IC
authors.lastname: Cozza
authors.forename: Thaisa H R
authors.initials: TH
authors.lastname: Di Sacco
authors.forename: José H
authors.initials: JH
authors.lastname: Mazon
authors.forename: Maria Cristina O
authors.initials: MC
authors.lastname: Salgado
authors.forename: Sabrina G V
authors.initials: SG
authors.lastname: Dutra
authors.forename: Evandro J
authors.initials: EJ
authors.lastname: Cesarino
authors.forename: Hugo C D
authors.initials: HC
authors.lastname: Souza
mesh_terms: D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D001341:Autonomic Nervous System / Q000187:drug effects / Q000503:physiopathology*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D004656:Enalapril / Q000494:pharmacology / Q000627:therapeutic use; D015444:Exercise / Q000502:physiology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D057185:Sedentary Behavior; D018667:Tilt-Table Test
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D004656:Enalapril