title: [Preparation and pharmaceutical characterization of Marine-SSL].
abstract: OBJECTIVE
  To prepare and characterize marine sterically stabilized liposomes (Marine-SSL).
  
  
  METHODS
  Liposomes were prepared by ethanol injection technique. An orthogonal test was utilized to optimize the formulation and preparation of Marine-SSL The unencapsulated marine and liposomes were separated by sephadex gel G-50, the encapsulation efficiency was detected by HPLC. The morphological examination of Marine-SSL was performed using transmission electron microscopy. The particle size and Zeta potential of the liposomes were measured. The in vitro release rate of marine from liposomes was tested.
  
  
  RESULTS
  The liposomes with spherical or ellipsoidal shape and better stability featured the encapsulation efficiency of (85.39 +/- 1.21)%, the mean partical size of (156 +/- 10) nm, and Zeta potential of (- 39.0 +/- 3.06) mv. The release kinetics in vitro obeyed Higuchi equation. The stability of Marine-SSL was better.
  
  
  CONCLUSIONS
  The selected formulation and preparation technic of Marine-SSL are rational and stable and liposomes feature a sustained release in vitro.
authors.affiliation: Department of Chinese Herbal Medicine, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510006, China. hollyzdq@126.com
authors.forename: Dong-Qing
authors.initials: DQ
authors.lastname: Zhang
authors.forename: Yi
authors.initials: Y
authors.lastname: Cheng
authors.forename: Cong-Lin
authors.initials: CL
authors.lastname: Bai
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wu
authors.forename: Gai-Hao
authors.initials: GH
authors.lastname: Pang
mesh_terms: D000470:Alkaloids / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004355:Drug Stability; D000431:Ethanol; D007887:Fabaceae / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D010316:Particle Size; D010743:Phospholipids / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D011807:Quinolizines / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D013678:Technology, Pharmaceutical / Q000379:methods*; D000093842:Matrines
chemical_list: D000470:Alkaloids; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D000431:Ethanol; D008081:Liposomes; D010743:Phospholipids; D011092:Polyethylene Glycols; D011807:Quinolizines; C037573:oxymatrine; D000093842:Matrines