title: Synthesis and antioxidant activity of substituted-1,3,2-diazaphosphole 1-oxides.
abstract: Synthesis of 1-substituted-1,3,2-diazaphosphole 1-oxides (3a-l) were accomplished via a two-step process. It involves the preparation of diazaphospholo 1-oxide monochloride intermediate (2) and its subsequent reaction with phenols/amino acid esters in dry THF in the presence of triethylamine at 40-45°C. The structures of newly synthesized compounds were characterized by spectral and elemental analysis. The title compounds were evaluated for their in-vitro antioxidant properties.
authors.affiliation: Department of Chemistry, Sri Venkateswara University, Tirupati, India.
authors.forename: Kalla Reddi Mohan
authors.initials: KR
authors.lastname: Naidu
authors.forename: Pasupuleti Visweswara
authors.initials: PV
authors.lastname: Rao
authors.forename: Chamarthi Naga
authors.initials: CN
authors.lastname: Raju
authors.forename: Kambam
authors.initials: K
authors.lastname: Srinivasulu
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D001921:Brain / Q000378:metabolism; D010087:Oxides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D010087:Oxides; D001205:Ascorbic Acid