title: Cerebrospinal Fluid Levels of sAPPα and sAPPβ in Lewy Body and Alzheimer's Disease: Clinical and Neurochemical Correlates.
abstract: We measured cerebrospinal fluid (CSF) levels of the soluble isoforms of amyloid precursor protein (APP; sAPPα sAPPβ) and other CSF biomarkers in 107 patients with Alzheimer's disease (AD), dementia with Lewy body dementia (DLB), Parkinson's disease dementia (PDD), and normal controls (NC) using commercial kits. DLB and PDD were combined in a Lewy body dementia group (LBD). No differences were observed in sAPPα and sAPPβ levels between the groups. Significant correlations were observed between sAPPα and sAPPβ and between sAPPβ and Mini-Mental State Examination scores in the total group analysis as well as when LBD and AD groups were analyzed separately. sAPPα and sAPPβ levels correlated with Aβ38, Aβ40, Aβ42, and Tau in the LBD group. In AD, sAPPα correlated with p-Tau and sAPPβ with Aβ40. The differential association between sAPPα and sAPPβ with Aβ and Tau species between LBD and AD groups suggests a possible relationship with the underlying pathologies in LBD and AD.
authors.affiliation: Centre for Age-Related Medicine, Stavanger University Hospital, 4068 Stavanger, Norway.
authors.forename: Ezra
authors.initials: E
authors.lastname: Mulugeta
authors.forename: Elisabet
authors.initials: E
authors.lastname: Londos
authors.forename: Oskar
authors.initials: O
authors.lastname: Hansson
authors.forename: Clive
authors.initials: C
authors.lastname: Ballard
authors.forename: Ragnhild
authors.initials: R
authors.lastname: Skogseth
authors.forename: Lennart
authors.initials: L
authors.lastname: Minthon
authors.forename: Kaj
authors.initials: K
authors.lastname: Blennow
authors.forename: Henrik
authors.initials: H
authors.lastname: Zetterberg
authors.forename: Dag
authors.initials: D
authors.lastname: Aarsland