title: Biomarker analysis for prostate cancer diagnosis using LC-MS and CE-MS.
abstract: Prostate cancer is one of the most common cancer types in men. In addition, it is the second leading cause of cancer death in the USA and Canada. Prostate cancer diagnosis is not a precise science yet. Discovery of potential biomarkers for early prostate cancer diagnosis and monitoring is crucially important. LC-MS and CE-MS have been widely used analytical techniques in the biomarker discovery. This review will describe the applications of LC-MS with different ionization techniques, such as ESI, atmospheric-pressure photoionization and atmospheric-pressure chemical ionization, and CE-MS techniques used in prostate cancer biomarker analysis.
authors.affiliation: Department of Chemistry & Environmental Research Center, Missouri University of Science & Technology, Rolla, MO 65409, USA.
authors.forename: Sanjeewa
authors.initials: S
authors.lastname: Gamagedara
authors.forename: Yinfa
authors.initials: Y
authors.lastname: Ma
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D015415:Biomarkers / Q000032:analysis* / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D003404:Creatinine / Q000652:urine; D003839:Deoxyadenosines / Q000032:analysis; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000032:analysis; D019075:Electrophoresis, Capillary; D006801:Humans; D008297:Male; D011453:Prostaglandins / Q000032:analysis; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D015415:Biomarkers; D003839:Deoxyadenosines; D011453:Prostaglandins; C078251:2'-deoxy-7,8-dihydro-8-oxoadenosine; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003404:Creatinine; D003849:Deoxyguanosine