title: Classic in vivo cancer models: three examples of mouse models used in experimental therapeutics.
abstract: Transplantable animal tumors have been associated with the discovery of most clinically active anticancer agents. They are still useful today in conducting detailed evaluations of new candidate anticancer drugs. Three protocols relating to transplantable experimental tumors are described in this unit. Included are the intravenously-implanted murine P388 leukemia, the subcutaneously-implanted murine B16 melanoma and two examples of subcutaneously-implanted human tumor xenografts, the LX-1 (lung) and MX-1 (breast) tumors.
authors.affiliation: Centre de Recherche Pierre Fabre, Cedex, France.
authors.forename: Anna
authors.initials: A
authors.lastname: Kruczynski
authors.forename: Bridget T
authors.initials: BT
authors.lastname: Hill
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D023041:Xenograft Model Antitumor Assays / Q000379:methods*