title: Effects of lycopene on oxidative stress and remnant liver histology after partial hepatectomy in rats.
abstract: OBJECTIVE
  Partial hepatectomy is performed for the treatment of mass lesions in the liver. Lycopene, which is a carotenoid, is present in various physiologic processes. In this study, the effects of lycopene administration in partially hepatectomized rats were evaluated by assessing various oxidant/antioxidant parameters, remnant liver histology and plasma nitric oxide levels.
  
  
  METHODS
  Thirty Wistar albino adult male rats were randomly divided into three equal groups as: Sham, Partial Hepatectomy and Lycopene-Administered + Partial Hepatectomy groups. Lycopene (4 mg/kg), which was dissolved in olive oil, was given to the rats per orally (via gavage tube) (0.1 ml) every day for 6 weeks before partial hepatectomy and for one week after partial hepatectomy. Tissue and blood samples were collected one week after partial hepatectomy.
  
  
  RESULTS
  Plasma malondialdehyde (p<0.001) and nitric oxide (p<0.05) levels in the lycopene-administered + partial hepatectomy group were significantly higher than in the partial hepatectomy group. Intraerythrocytic glutathione (p<0.001), plasma (p<0.001) and liver tissue Cu-Zn (p<0.05) superoxide dismutase levels of the lycopene-administered + partial hepatectomy group were significantly lower than in the partial hepatectomy group.
  
  
  CONCLUSIONS
  Lycopene administration could be harmful by increasing oxidative stress after partial hepatectomy.
authors.affiliation: Department of 1General Surgery, ‹stanbul University, Cerrahpasa Medical School, Istanbul, Turkey. eaytactr@yahoo.com
authors.forename: Erman
authors.initials: E
authors.lastname: Aytac
authors.forename: Fadıl
authors.initials: F
authors.lastname: Ayan
authors.forename: Seha
authors.initials: S
authors.lastname: Saygili
authors.forename: Habibe
authors.initials: H
authors.lastname: Genç
authors.forename: Cetin
authors.initials: C
authors.lastname: Karaca
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Bayrak
authors.forename: Hafize
authors.initials: H
authors.lastname: Uzun
authors.forename: Ziya
authors.initials: Z
authors.lastname: Salıhoğlu
authors.forename: Sibel
authors.initials: S
authors.lastname: Erdamar
authors.forename: Volkan
authors.initials: V
authors.lastname: Sözer
authors.forename: Tuncay
authors.initials: T
authors.lastname: Altuğ
authors.forename: Pınar
authors.initials: P
authors.lastname: Seymen
authors.forename: Hakkı Oktay
authors.initials: HO
authors.lastname: Seymen
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D002338:Carotenoids / Q000008:administration & dosage*; D005978:Glutathione / Q000187:drug effects / Q000378:metabolism; D006498:Hepatectomy; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D000077276:Lycopene; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D011184:Postoperative Period; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000187:drug effects / Q000378:metabolism
chemical_list: D000975:Antioxidants; D009569:Nitric Oxide; D002338:Carotenoids; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D005978:Glutathione; D000077276:Lycopene