title: The influence of obesity on androstenedione to testosterone ratio in women with polycystic ovary syndrome (PCOS) and hyperandrogenemia.
abstract: The aim of the present study was to evaluate the impact of obesity and insulin resistance on testosterone formation from androstenedione and its contribution to biochemical hyperandrogenemia in all different phenotypic subgroups of PCOS patients. The case-control study included 1087 PCOS women and 206 regularly menstruating, ovulatory controls. The main clinical measurements included anthropometric and basal hormonal characteristics and evaluation of hyperandrogenic and insulin resistance-related features. The results were the following: In PCOS women with biochemical hyperandrogenemia, obesity significantly lowers serum A levels and increases T to A ratio. These findings were not present in PCOS women with clinical hypeandrogenemia and in normal ovulatory controls.
authors.affiliation: Division of Endocrinology and Human Reproduction, 2nd Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: G
authors.initials: G
authors.lastname: Misichronis
authors.forename: N A
authors.initials: NA
authors.lastname: Georgopoulos
authors.forename: D J
authors.initials: DJ
authors.lastname: Marioli
authors.forename: A K
authors.initials: AK
authors.lastname: Armeni
authors.forename: I
authors.initials: I
authors.lastname: Katsikis
authors.forename: A D
authors.initials: AD
authors.lastname: Piouka
authors.forename: A D
authors.initials: AD
authors.lastname: Saltamavros
authors.forename: N D
authors.initials: ND
authors.lastname: Roupas
authors.forename: D
authors.initials: D
authors.lastname: Panidis
mesh_terms: D000293:Adolescent; D000328:Adult; D000735:Androstenedione / Q000097:blood*; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood* / Q000150:complications; D009765:Obesity / Q000097:blood* / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications; D013739:Testosterone / Q000097:blood*; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: D013739:Testosterone; D000735:Androstenedione