title: Autophagy: cells SNARE selves.
abstract: Autophagosomes sequester cytosolic constituents and deliver this cargo to lysosomes for destruction. Two groups now report that autophagosome maturation requires homotypic membrane fusion catalyzed by SNARE proteins.
authors.affiliation: Department of Molecular Physiology and Biological Physics and Center for Membrane Biology, University of Virginia, Charlottesville, VA, USA. chris.stroupe@virginia.edu
authors.forename: Christopher
authors.initials: C
authors.lastname: Stroupe
mesh_terms: D001343:Autophagy / Q000502:physiology*; D000071190:Autophagy-Related Protein 8 Family; D000071183:Autophagy-Related Proteins; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D022162:Cytoplasmic Vesicles / Q000378:metabolism; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism / Q000502:physiology; D008561:Membrane Fusion; D008565:Membrane Proteins / Q000378:metabolism / Q000502:physiology; D008869:Microtubule-Associated Proteins / Q000378:metabolism / Q000502:physiology; D008954:Models, Biological; D010588:Phagosomes / Q000378:metabolism / Q000502:physiology; D050600:SNARE Proteins / Q000378:metabolism / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism / Q000502:physiology
chemical_list: C518959:ATG16L1 protein, human; C113757:ATG8 protein, S cerevisiae; C434065:ATG9 protein, S cerevisiae; D000071190:Autophagy-Related Protein 8 Family; D000071183:Autophagy-Related Proteins; D002352:Carrier Proteins; D008565:Membrane Proteins; D008869:Microtubule-Associated Proteins; D050600:SNARE Proteins; D029701:Saccharomyces cerevisiae Proteins