title: A case of congenital hyperostosis in a newborn piglet.
abstract: One female newborn piglet showed prominent thickening of both forelimbs and died soon after birth. Histopathologically, thin and woven trabeculae of bone was extending out from the edge of cortical bone in the affected forelimbs, and diagnosed as congenital hyperostosis. The extent of radially proliferated trabeculae was most prominent in radioulna. Many round- to spindle-shaped cells were observed in periosteum, which were considered to be osteoblasts. Around the periosteum, the mesenchymal proliferation was extensive with abundant mucus, and cartilaginous metaplastic changes were observed mainly around the radioulna and humerus. Dilatation of vessels with fibrin deposition in vessel walls was often observed, which were considered to reflect the localized circulatory disturbance.
authors.affiliation: Nippon Institute for Biological Science, 9–2221–1 Shinmachi, Ome, Tokyo 198–0024, Japan. koji_ue@nibs.or.jp
authors.forename: Koji
authors.initials: K
authors.lastname: Uetsuka
authors.forename: Takayuki
authors.initials: T
authors.lastname: Suzuki
authors.forename: Hirohito
authors.initials: H
authors.lastname: Ogawa
authors.forename: Hiroko
authors.initials: H
authors.lastname: Sato
authors.forename: Kunio
authors.initials: K
authors.lastname: Doi
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Nunoya
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D017809:Fatal Outcome; D005260:Female; D005552:Forelimb / Q000473:pathology; D006958:Hyperostosis, Cortical, Congenital / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry / Q000662:veterinary; D013552:Swine; D013553:Swine Diseases / Q000473:pathology*