title: Facile synthesis of hybrid sulfonophosphinodipeptides composing of taurines and 1-aminoalkylphosphinic acids.
abstract: Both sulfonopeptides and phosphonopeptides are important analogs of naturally occurring peptides and have been widely used as enzyme inhibitors and haptens for producing catalytic antibodies due to their tetrahedrally structural features. A series of hybrid sulfonophosphinodipeptides composing of taurines and 1-aminoalkylphosphinic acids were first and conveniently synthesized in satisfactory to good yields via a Mannich-type reaction of N-benzyloxycarbonylaminoalkanesulfonamides, aldehydes, and aryldichlorophosphines, and subsequent hydrolysis. The current method provides an efficient and direct synthesis of hybrid sulfonophosphinodipeptides.
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Department of Organic Chemistry, Faculty of Science, Beijing University of Chemical Technology, Beijing, 100029, People's Republic of China.
authors.forename: Fanhua
authors.initials: F
authors.lastname: Meng
authors.forename: Fengdan
authors.initials: F
authors.lastname: He
authors.forename: Xiuqing
authors.initials: X
authors.lastname: Song
authors.forename: Leilei
authors.initials: L
authors.lastname: Zhang
authors.forename: Wenxiang
authors.initials: W
authors.lastname: Hu
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.forename: Jiaxi
authors.initials: J
authors.lastname: Xu
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D004151:Dipeptides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010721:Phosphinic Acids / Q000032:analysis* / Q000138:chemical synthesis* / Q000737:chemistry*; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry*; D013654:Taurine / Q000032:analysis*
chemical_list: D000447:Aldehydes; D004151:Dipeptides; D010721:Phosphinic Acids; D013449:Sulfonamides; D013654:Taurine