title: Plasma dehydroepiandrosterone sulphate and insulin-like growth factor I levels in obstructive sleep apnoea syndrome.
abstract: BACKGROUND
  We aimed to assess whether obstructive sleep apnoea syndrome (OSAS) affects plasma IGF-1 and dehydroepiandrosterone sulphate (DHEA-S) levels in men, factors implicated in the development of age-related metabolic disorders.
  
  
  METHODS
  We conducted a cross-sectional and longitudinal clinical study.
  
  
  METHODS
  We measured plasma IGF-1 and DHEA-S levels in 191 non-drug-treated Japanese men (34 primary snorers (PS), 88 patients with mild-to-moderate OSAS and 69 patients severe OSAS ).
  
  
  RESULTS
  Plasma IGF-1 and DHEA-S were negatively correlated with age. Plasma IGF-1 was also negatively correlated with plasma glucose, HOMA-IR and systolic blood pressure and apnoea parameters such as the apnoea-hypopnea index, minimum oxygen saturation and slow-wave sleep (SWS) time. Plasma DHEA-S was associated with plasma glucose, HbA1c and free fatty acid and was negatively correlated with SWS time. To eliminate the influence of age, PS, patients with mild-to-moderate OSAS and severe OSAS were divided into three groups by age: young (<40 years), middle-aged (40-59 years) and elderly (≥ 60 years). Patients with severe OSAS aged <40 or <60 years had lower plasma IGF-1 or DHEA-S levels, respectively, than did the corresponding snorers and mild-to-moderate OSAS groups. Continuous positive airway pressure therapy for generally 16-18 months increased plasma IGF-1 levels in patients with severe OSAS aged <40 years (n = 18). Plasma DHEA-S levels were increased in patients with severe OSAS aged <60 years, whose DHEA-S level was below the mean value for that age (n = 23/41).
  
  
  CONCLUSIONS
  Severe OSAS could reduce plasma IGF-1 and DHEA-S levels in younger, but not elderly Japanese men, which is potentially associated with the development of metabolic abnormalities.
authors.affiliation: Department of Internal Medicine, Osaka Gyomeikan Hospital, Kasugade-naka, Konohana-ku, Osaka, Japan. makinos@ares.eonet.ne.jp
authors.forename: Shinya
authors.initials: S
authors.lastname: Makino
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Fujiwara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Handa
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Fujie
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Aoki
authors.forename: Kozo
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Terada
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Sugimoto
mesh_terms: D000328:Adult; D000367:Age Factors; D003430:Cross-Sectional Studies; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000378:metabolism*
chemical_list: D019314:Dehydroepiandrosterone Sulfate; D007334:Insulin-Like Growth Factor I