title: Periodic force induced stabilization or destabilization of the denatured state of a protein.
abstract: We have studied the effects of an external sinusoidal force in protein folding kinetics. The externally applied force field acts on the each amino acid residues of polypeptide chains. Our simulation results show that mean protein folding time first increases with driving frequency and then decreases passing through a maximum. With further increase of the driving frequency the mean folding time starts increasing as the noise-induced hoping event (from the denatured state to the native state) begins to experience many oscillations over the mean barrier crossing time period. Thus unlike one-dimensional barrier crossing problems, the external oscillating force field induces both stabilization or destabilization of the denatured state of a protein. We have also studied the parametric dependence of the folding dynamics on temperature, viscosity, non-Markovian character of bath in presence of the external field.
authors.affiliation: Advanced Science Institute, RIKEN, Wako, Saitama 351-0198, Japan. gpulakchem@gmail.com
authors.forename: Pulak Kumar
authors.initials: PK
authors.lastname: Ghosh
authors.forename: Mai Suan
authors.initials: MS
authors.lastname: Li
authors.forename: Bidhan Chandra
authors.initials: BC
authors.lastname: Bag
mesh_terms: D007700:Kinetics; D008958:Models, Molecular; D011489:Protein Denaturation; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D011506:Proteins