title: Evaluation of the clinical efficacy of a betaine-containing mouthwash and an intraoral device for the treatment of dry mouth.
abstract: OBJECTIVE
  An evaluation is made of the efficacy and safety of an intraoral device with a betaine (BET)-containing mouthwash in treating xerostomia.
  
  
  METHODS
  A total of 105 patients with dry mouth (xerostomia) were included in a randomized, non-blinded, parallel-group, controlled clinical trial. The patients were assigned to one of the three groups: A (night guard), B (mouthwash), or C (night guard and mouthwash). A xerostomia questionnaire was administered, and unstimulated salivary flow was measured. The Oral Health Impact Profile (OHIP) - 14 was assessed. All measurements were taken before and after treatment, which had a duration of 4 weeks. The patients in turn completed a treatment satisfaction questionnaire.
  
  
  RESULTS
  Ninety patients (eight men and 82 women) completed the study. All three treatments alleviated the symptoms of xerostomia, with improvement in the OHIP-14 scores and sialometry findings. There were no adverse effects. Patient satisfaction with the treatment received showed no statistically significant differences among the three groups; though, the patients in group A considered treatment to have been extremely beneficial in 10% of the cases, while 43% considered it to have been beneficial.
  
  
  CONCLUSIONS
  The daily use of a night guard and BET-containing mouthwash was seen to improve dry mouth during the 4-week duration of the study.
authors.affiliation: Department of Oral Medicine, University of Murcia, Murcia, Spain. majornet@um.es
authors.forename: Pia
authors.initials: P
authors.lastname: López-Jornet
authors.forename: Fabio
authors.initials: F
authors.lastname: Camacho-Alonso
authors.forename: Consuelo
authors.initials: C
authors.lastname: Rodriguez-Aguado
mesh_terms: D001622:Betaine / Q000627:therapeutic use*; D003679:Deglutition / Q000502:physiology; D004435:Eating / Q000502:physiology; D005260:Female; D006801:Humans; D008046:Lip / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000503:physiopathology; D009064:Mouth Protectors; D009067:Mouthwashes / Q000627:therapeutic use*; D017060:Patient Satisfaction; D010614:Pharynx / Q000503:physiopathology; D020011:Protective Agents / Q000627:therapeutic use*; D011788:Quality of Life; D012463:Saliva / Q000378:metabolism; D012636:Secretory Rate / Q000502:physiology; D013060:Speech / Q000502:physiology; D013649:Taste / Q000502:physiology; D013894:Thirst / Q000502:physiology; D014059:Tongue / Q000503:physiopathology; D014987:Xerostomia / Q000188:drug therapy / Q000628:therapy*
chemical_list: D009067:Mouthwashes; D020011:Protective Agents; D001622:Betaine