title: New-onset psoriasis associated with adalimumab: a report of two cases.
abstract: TNF-α inhibitors, including adalimumab, are increasingly used in the management of inflammatory cutaneous, gastrointestinal, and rheumatologic diseases. An untoward class effect of these medications is the development of new-onset psoriasis, particularly in patients treated for rheumatologic diseases without any personal or family history of cutaneous psoriasis. We report two patients that developed cutaneous and histologic changes consistent with psoriasis while receiving treatment with adalimumab for inflammatory arthridities: one patient with Crohn disease and ankylosing spondylitis who tolerated adalimumab for 15 months before developing psoriasis and another patient with rheumatoid arthritis who developed psoriasis 3 years after starting adalimumab. Both patients experienced rapid resolution of their psoriasis after discontinuation of adalimumab.
authors.affiliation: University of Florida College of Medicine, Gainesville, Florida, USA.
authors.forename: Candace J
authors.initials: CJ
authors.lastname: Glenn
authors.forename: Katherina B
authors.initials: KB
authors.lastname: Kobraei
authors.forename: Jacqueline J
authors.initials: JJ
authors.lastname: Russo
mesh_terms: D000068879:Adalimumab; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D003424:Crohn Disease / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000139:chemically induced*; D013167:Spondylitis, Ankylosing / Q000188:drug therapy
chemical_list: D000893:Anti-Inflammatory Agents; D061067:Antibodies, Monoclonal, Humanized; D000068879:Adalimumab