title: Successful mobilization of peripheral blood stem cells in children with cancer using plerixafor (Mozobil) and granulocyte-colony stimulating factor.
abstract: This paper describes the successful mobilization of peripheral blood stem cells for autologous transplantation in three children with malignant diseases by using plerixafor (Mozobil; Genzyme Corporation, Cambridge, MA) and granulocyte-colony stimulating factor (G-CSF) after failed previous mobilizations. A median sixfold increase in the number of circulating CD34+ cells after plerixafor treatment as compared with the baseline level was observed. An optimal CD34+ cell count for transplantation with one or two leukapheresis sessions was achieved. Mobilization using plerixafor was found to be safe with no adverse events. Therefore, the combination of G-CSF and plerixafor in children results in effective increases in peripheral CD34+ cell counts and reduces the risk of mobilization failure.
authors.affiliation: Specialized Hospital for Treatment of Children with Onco-Haematological Diseases, Sofia, Bulgaria. b.avramova@sbaldohz.com
authors.forename: Boryana E
authors.initials: BE
authors.lastname: Avramova
authors.forename: Maya N
authors.initials: MN
authors.lastname: Yordanova
authors.forename: Dobrin N
authors.initials: DN
authors.lastname: Konstantinov
authors.forename: Dragan G
authors.initials: DG
authors.lastname: Bobev
mesh_terms: D000293:Adolescent; D018952:Antigens, CD34 / Q000378:metabolism; D001596:Benzylamines; D001772:Blood Cell Count; D002648:Child; D000080027:Cyclams; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage*; D019650:Hematopoietic Stem Cell Mobilization / Q000009:adverse effects / Q000379:methods; D006571:Heterocyclic Compounds / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007937:Leukapheresis / Q000379:methods; D008297:Male; D009369:Neoplasms / Q000628:therapy*; D036102:Peripheral Blood Stem Cell Transplantation / Q000379:methods*; D014182:Transplantation, Autologous; D016896:Treatment Outcome
chemical_list: D018952:Antigens, CD34; D001596:Benzylamines; D000080027:Cyclams; D006571:Heterocyclic Compounds; D016179:Granulocyte Colony-Stimulating Factor; C088327:plerixafor