title: Copper handling by astrocytes: insights into neurodegenerative diseases.
abstract: Copper (Cu) is an essential trace element in the brain that can be toxic at elevated levels. Cu accumulation is a suspected etiology in several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and prion-induced disorders. Astrocytes are a proposed depot in the brain for Cu and other metals, including lead (Pb). This article describes the physiological roles of Cu in the central nervous system and in selected neurodegenerative diseases, and reviews evidence that astrocytes accumulate Cu and protect neurons from Cu toxicity. Findings from murine genetic models of Menkes disease and from cell culture models concerning the molecular mechanisms by which astrocytes take up, store, and buffer Cu intracellularly are discussed, as well as potential mechanistic linkages between astrocyte functions in Cu handling and neurodegenerative diseases.
authors.affiliation: Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843, USA. ecastiglioni@cvm.tamu.edu
authors.forename: Evelyn
authors.initials: E
authors.lastname: Tiffany-Castiglioni
authors.forename: Sandra
authors.initials: S
authors.lastname: Hong
authors.forename: Yongchang
authors.initials: Y
authors.lastname: Qian
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000378:metabolism*; D002490:Central Nervous System / Q000187:drug effects / Q000502:physiology; D003300:Copper / Q000378:metabolism* / Q000633:toxicity; D004195:Disease Models, Animal; D006801:Humans; D019636:Neurodegenerative Diseases / Q000139:chemically induced / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*
chemical_list: D003300:Copper