title: No evidence for association between DRD3 and COMT with schizophrenia in a Malay population.
abstract: Molecular components of the dopamine D3 receptor  (DRD3) may play an important role in the pathophysiology of schizophrenia.  Previous studies have demonstrated an association between DRD3 Ser9Gly and  cathechol-o-methyltransferase (COMT, SNP = rs165656) polymorphisms and  schizophrenia but the results were inconclusive. We investigated this apparent  association between Ser9Gly (A/G) polymorphism and an intronic SNP (dbSNP or  rs165656) in 261 Malay patients diagnosed with schizophrenia and 216 controls,  using PCR-RFLP. The genotype distribution of the polymorphism DRD3 Ser9Gly was  in Hardy-Weinberg equilibrium (HWE) for patients (P = 0.1251) and out of HWE  for controls (P = 0.0137). However, both healthy controls and schizophrenia  patients were out of HWE for the polymorphism COMT rs165656. Based on allele  and genotype frequencies in both groups, we found no significant association of  DRD3 Ser9Gly polymorphisms and COMT (rs165656) with schizophrenia in Malays.  Further studies should examine the association between other dopamine-related  genes and the behavioral phenotypes of schizophrenia.
authors.affiliation: Department of Chemical Engineering, Faculty of Engineering and Science, Universiti Tunku Abdul Rahman, Kuala Lumpur, Malaysia.
authors.forename: S F
authors.initials: SF
authors.lastname: Tee
authors.forename: P Y
authors.initials: PY
authors.lastname: Tang
authors.forename: H C
authors.initials: HC
authors.lastname: Loh
mesh_terms: D000328:Adult; D000368:Aged; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008296:Malaysia; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D050637:Receptors, Dopamine D3 / Q000235:genetics*; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*
chemical_list: C493593:DRD3 protein, human; D050637:Receptors, Dopamine D3; D002394:Catechol O-Methyltransferase