title: Family history of dementia predicts worse neuropsychological functioning among HIV-infected persons.
abstract: HIV-negative individuals with a family history of dementia (FHD) are more likely to develop dementia than those without FHD. Whether FHD increases risk for neuropsychological (NP) impairment in HIV+ persons is unknown. As part of a multisite study into HIV-associated neurocognitive disorders (HAND), the authors captured FHD with a free-response, self-report question, and assessed NP performance with a comprehensive battery of tests. The authors examined HIV+ persons with (N=190) and without (N=916) self-reported FHD. Despite the fact that the FHD group had factors typically associated with better NP performance (e.g., higher CD4 counts and estimated verbal IQ), persons with FHD had significantly worse NP ability than those without FHD as measured by a Global Deficit Score. Thus, FHD appears to be a risk factor for HAND; the mechanism(s) underlying how FHD contributes to NP impairment among HIV+ persons warrants study.
authors.affiliation: Dept. of Psychiatry, University of California, San Diego (UCSD) and the HIV Neurobehavioral Research Center (HNRC), UCSD, CA, USA. djmoore@ucsd.edu
authors.forename: David J
authors.initials: DJ
authors.lastname: Moore
authors.forename: Miguel
authors.initials: M
authors.lastname: Arce
authors.forename: Suzanne
authors.initials: S
authors.lastname: Moseley
authors.forename: J Allen
authors.initials: JA
authors.lastname: McCutchan
authors.forename: Jennifer
authors.initials: J
authors.lastname: Marquie-Beck
authors.forename: Donald R
authors.initials: DR
authors.lastname: Franklin
authors.forename: Florin
authors.initials: F
authors.lastname: Vaida
authors.forename: Cristian L
authors.initials: CL
authors.lastname: Achim
authors.forename: Justin
authors.initials: J
authors.lastname: McArthur
authors.forename: Susan
authors.initials: S
authors.lastname: Morgello
authors.forename: David M
authors.initials: DM
authors.lastname: Simpson
authors.forename: Benjamin B
authors.initials: BB
authors.lastname: Gelman
authors.forename: Ann C
authors.initials: AC
authors.lastname: Collier
authors.forename: Christina M
authors.initials: CM
authors.lastname: Marra
authors.forename: David B
authors.initials: DB
authors.lastname: Clifford
authors.forename: Robert K
authors.initials: RK
authors.lastname: Heaton
authors.forename: Igor
authors.initials: I
authors.lastname: Grant
mesh_terms: D000328:Adult; D018791:CD4 Lymphocyte Count; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology* / Q000821:virology; D056344:Executive Function / Q000502:physiology; D005192:Family Health; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009048:Motor Skills / Q000502:physiology; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D014705:Verbal Behavior / Q000502:physiology