title: Variations in serum 25-hydroxyvitamin D during acute pancreatitis: an exploratory longitudinal study.
abstract: OBJECTIVE
  We tested the hypothesis that 25-hydroxyvitamin D3 (25OHD) changes during acute inflammation in humans.
  
  
  METHODS
  Patients with first episode of acute pancreatitis were included. Blood samples were acquired on admission and on days 1, 2, and 14.
  
  
  RESULTS
  In total, 73 patients (35 males, median age 59) entered the study. On admission, the distribution of 25-OHD levels was as follows: severely deficient (<13 nmol/L) 23%; deficient (13-25 nmol/L) 20%; insufficient (26-50 nmol/L) 40%; and normal (<50 nmol/L) 17%. There was a significant fall and linear trend in 25OHD, albumin, and hemoglobin from day 0 to day 2. From day 0 to day 2 the drop in 25OHD was 3.1 nmol/L (95% CI 0.59-5.63). The changes from day 0 to day 2 in 25OHD were associated with changes in C-reactive protein (p = 0.02) but not with leukocyte or monocyte count.
  
  
  CONCLUSIONS
  The 25OHD levels dropped during the first 2 days of acute pancreatitis beyond what was expected based on 25OHD half-life. This study supports our hypothesis that an acute inflammatory condition utilizes 25OHD, but other mechanisms could interfere.
authors.affiliation: Department of Endocrinology, Hvidovre Hospital, Copenhagen, Denmark. ulrichbangbang@gmail.com
authors.forename: Ulrich C
authors.initials: UC
authors.lastname: Bang
authors.forename: Srdan
authors.initials: S
authors.lastname: Novovic
authors.forename: Anders Møller
authors.initials: AM
authors.lastname: Andersen
authors.forename: Mogens
authors.initials: M
authors.lastname: Fenger
authors.forename: Mark Berner
authors.initials: MB
authors.lastname: Hansen
authors.forename: Jens-Erik Beck
authors.initials: JE
authors.lastname: Jensen
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000378:metabolism; D002112:Calcifediol / Q000097:blood*; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007958:Leukocyte Count; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000097:blood*; D012044:Regression Analysis; D012709:Serum Albumin / Q000378:metabolism; D014808:Vitamin D Deficiency / Q000097:blood*; D055815:Young Adult
chemical_list: D006454:Hemoglobins; D012709:Serum Albumin; D002097:C-Reactive Protein; D002112:Calcifediol