title: [Studies on preparation and dissolution test in vitro of intragastric floating two-chamber osmotic pump tablets of total alkaloids of Coptis chinensis and Evodia rutaecarpa].
abstract: OBJECTIVE
  To study prescription and technique of intragastric floating two-chamber osmotic pump tablets (TCOPT) of total alkaloids of Coptis chinensis and Evodia rutaecarpa and inspect release property in vitro.
  
  
  METHODS
  The orthogonal experiment was designed to screen prescription and technique.
  
  
  RESULTS
  The optimization of prescription and technique were as follows: the expanding agent was a mixture of PEO and HPMC as a ratio of 4:1; the osmotic agent in propelling layer contained sodium chloride 20 mg, PEG 400 in the cellulose acetate, 10%; coating membrane in core tablet, 9%. The release behavior of TCOPT coincidented with zero-level equation well and the character of controlled-release was transparent.
  
  
  CONCLUSIONS
  TCOPT has good effect of controlled-release in vitro and the release behavior in vivo need to be inspected.
authors.affiliation: Pharmacy Faculty of Hebei Medical University, Shijiazhuang 050017, China. triqq@126.com
authors.forename: Yu
authors.initials: Y
authors.lastname: Fang
authors.forename: Qing-Wen
authors.initials: QW
authors.lastname: Shi
mesh_terms: D000470:Alkaloids / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics*; D002626:Chemistry, Pharmaceutical; D039323:Coptis / Q000737:chemistry*; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D004355:Drug Stability; D032086:Evodia / Q000737:chemistry*; D005079:Excipients / Q000737:chemistry; D005638:Fruit / Q000737:chemistry; D005753:Gastric Mucosa / Q000378:metabolism*; D009995:Osmosis; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry; D012965:Sodium Chloride / Q000737:chemistry; D012995:Solubility; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D000470:Alkaloids; D003692:Delayed-Action Preparations; D005079:Excipients; D013607:Tablets; D011092:Polyethylene Glycols; D012965:Sodium Chloride