title: Experimental microsphere targeting in a representative hepatic artery system.
abstract: Recent work employing the computational fluid-particle modeling of the hepatic arteries has identified a correlation between particle release position and downstream branch distribution for direct tumor-targeting in radioembolization procedures. An experimental model has been constructed to evaluate the underlying simulation theory and determine its feasibility for future clinical use. A scaled model of a generalized hepatic system with a single inlet and five outlet branches was fabricated to replicate the fluid dynamics in the hepatic arteries of diseased livers. Assuming steady flow, neutrally buoyant microspheres were released from controlled locations within the inlet of the model and the resulting output distributions were recorded. Fluid and particle transport simulations were conducted with identical parameters. The resulting experimentally and simulation-derived microsphere distributions were compared. The experimental microsphere distribution exhibited a clear dependence on injection location that correlated very strongly with the computationally predicted results. Individual branch targeting was possible for each of the five outputs. The experimental results validate the simulation methodology for achieving targeted microsphere distributions in a known geometry under constant flow conditions.
authors.affiliation: Department of Mechanical Engineering, North Carolina State University, Raleigh, NC 27695, USA. andy_richards@ncsu.edu
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Richards
authors.forename: Clement
authors.initials: C
authors.lastname: Kleinstreuer
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Kennedy
authors.forename: Emily
authors.initials: E
authors.lastname: Childress
authors.forename: Gregory D
authors.initials: GD
authors.lastname: Buckner
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D001790:Blood Physiological Phenomena; D001918:Brachytherapy / Q000295:instrumentation*; D003198:Computer Simulation; D004337:Drug Carriers / Q000737:chemistry*; D006499:Hepatic Artery / Q000503:physiopathology*; D006801:Humans; D008863:Microspheres; D008955:Models, Cardiovascular; D009038:Motion; D019275:Radiopharmaceuticals / Q000737:chemistry*; D012212:Rheology / Q000379:methods*
chemical_list: D004337:Drug Carriers; D019275:Radiopharmaceuticals