title: Triterpenoids with rare carbon skeletons from Salvia hydrangea: antiprotozoal activity and absolute configurations.
abstract: Salvadione C (1) and perovskone B (2), two new triterpenoids with rare carbon skeletons, were isolated from an antiplasmodial n-hexane extract of Salvia hydrangea. The absolute configuration was determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra. In vitro activity against Plasmodium falciparum K1 strain, Trypanosoma brucei rhodesiense STIB 900 strain, and cytotoxicity in rat myoblast (L6) cells were determined. Compounds 1 and 2 showed in vitro antiplasmodial activity, with IC50 values of 1.43 and 0.18 μM and selectivity indices (SI) of 86.2 and 69.6, respectively. IC50 values against T. brucei rhodesiense were found to be 4.33 and 15.92 μM, respectively.
authors.affiliation: Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin, Tehran, Iran. m_moridi@sbu.ac.ir
authors.forename: M
authors.initials: M
authors.lastname: Moridi Farimani
authors.forename: M Babak
authors.initials: MB
authors.lastname: Bahadori
authors.forename: Salman
authors.initials: S
authors.lastname: Taheri
authors.forename: Samad N
authors.initials: SN
authors.lastname: Ebrahimi
authors.forename: Stefanie
authors.initials: S
authors.lastname: Zimmermann
authors.forename: Reto
authors.initials: R
authors.lastname: Brun
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Amin
authors.forename: Matthias
authors.initials: M
authors.lastname: Hamburger
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007492:Iran; D015394:Molecular Structure; D032446:Myoblasts / Q000187:drug effects; D021261:Parasitic Sensitivity Tests; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D051381:Rats; D027544:Salvia / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D016833:Trypanosoma brucei rhodesiense / Q000187:drug effects
chemical_list: D000981:Antiprotozoal Agents; D014315:Triterpenes; C569059:perovskone B; C569060:salvadione C