title: The nuclear envelope as a chromatin organizer.
abstract: In the past 15 years our perception of nuclear envelope function has evolved perhaps nearly as much as the nuclear envelope itself evolved in the last 3 billion years. Historically viewed as little more than a diffusion barrier between the cytoplasm and the nucleoplasm, the nuclear envelope is now known to have roles in the cell cycle, cytoskeletal stability and cell migration, genome architecture, epigenetics, regulation of transcription, splicing, and DNA replication. Here we will review both what is known and what is speculated about the role of the nuclear envelope in genome organization, particularly with respect to the positioning and repositioning of genes and chromosomes within the nucleus during differentiation.
authors.affiliation: The Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, EH9 3JR, UK.
authors.forename: Nikolaj
authors.initials: N
authors.lastname: Zuleger
authors.forename: Michael I
authors.initials: MI
authors.lastname: Robson
authors.forename: Eric C
authors.initials: EC
authors.lastname: Schirmer
mesh_terms: D002467:Cell Nucleus / Q000502:physiology; D002843:Chromatin / Q000378:metabolism*; D002875:Chromosomes / Q000502:physiology; D009685:Nuclear Envelope / Q000378:metabolism*; D022022:Nuclear Pore / Q000502:physiology; D009687:Nuclear Proteins / Q000378:metabolism
chemical_list: D002843:Chromatin; D009687:Nuclear Proteins