title: DTI analyses and clinical applications in Alzheimer's disease.
abstract: DTI is one of the most effective MR tools for the investigation of the brain anatomy. In addition to the gray matter, histopathological studies indicate that white matter is also a good target for both the early diagnosis of AD and for monitoring disease progression, which motivates us to use DTI to study AD patients in vivo. There are already a large amount of studies reporting significant differences between AD patients and controls, as well as to predict progression of disease in symptomatic non-demented individuals. Application of these findings in clinical practice remains to be demonstrated.
authors.affiliation: The Russell H. Morgan Department of Radiology and Radiological Science, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA. koishi@mri.jhu.edu
authors.forename: Kenichi
authors.initials: K
authors.lastname: Oishi
authors.forename: Michelle M
authors.initials: MM
authors.lastname: Mielke
authors.forename: Marilyn
authors.initials: M
authors.lastname: Albert
authors.forename: Constantine G
authors.initials: CG
authors.lastname: Lyketsos
authors.forename: Susumu
authors.initials: S
authors.lastname: Mori
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications / Q000175:diagnosis*; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D003072:Cognition Disorders / Q000209:etiology / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales