title: FOXP1 and PAX5 are rare but recurrent translocations partners in acute lymphoblastic leukemia.
abstract: Here, we report the case of a 57-year-old man, who was diagnosed with B-cell acute lymphoblastic leukemia (B-ALL). His diagnostic workup identified a translocation t(3;9)(p13;p13). This is the fifth case reported to date that involved the forkhead box P1 gene (FOXP1) and paired box gene 5 (PAX5). The PAX5-FOXP1 translocation is a nonrandom aberration, which is recurrent in both childhood and in adult B-ALL, and may contribute to leukemogenesis by blocking differentiation of hematopoietic cells into mature B-cells.
authors.affiliation: Department of Human Genetics, Universitaire Ziekenhuizen Leuven, Katholieke Universiteit Leuven, Leuven, Belgium.
authors.forename: Natalie
authors.initials: N
authors.lastname: Put
authors.forename: Dries
authors.initials: D
authors.lastname: Deeren
authors.forename: Lucienne
authors.initials: L
authors.lastname: Michaux
authors.forename: Peter
authors.initials: P
authors.lastname: Vandenberghe
mesh_terms: D001402:B-Lymphocytes / Q000473:pathology; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D051858:Forkhead Transcription Factors / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D051757:PAX5 Transcription Factor / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*
chemical_list: C486626:FOXP1 protein, human; D051858:Forkhead Transcription Factors; D015514:Oncogene Proteins, Fusion; D051757:PAX5 Transcription Factor; C497281:PAX5 protein, human; D012097:Repressor Proteins