title: An evaluation of prognostic value of death-associated protein kinase 1 in breast cancer.
abstract: BACKGROUND
  The benefit of tissue microarray (TMA) is its capability to analyse large numbers of tissue samples in a uniform fashion. This study was designed to evaluate the capability of TMA for analyzing the status of death-associated protein kinase 1 (DAPK1) in breast cancer patient and to explore its potential in the management of breast cancer.
  
  
  METHODS
  Over a 60-month period, tissue specimens of 99 patients with primary invasive breast cancer were selected. Tissue microarray (TMA) was applied to detect the DAPK1 expression. The data for the other clinicopathologic variables, including age, histological grading, estrogen receptor status and TNM staging were also recorded.
  
  
  RESULTS
  Tumor in 11 patients (11.1%) scored 1 for DAPK1 expression, 55 patients (55.6%) scored 2 and 33 (33.3%) scored 3. We found no obvious link between DAPK1 expression and age, histologic grading, primary tumor staging, lymph node status, estrogen receptor and TNM stage. TNM staging was found to be significantly linked to the overall five-year survival rate through multivariate analysis.
  
  
  CONCLUSIONS
  DAPK1 expression did not show any meaningful value in predicting outcome for patients with breast cancer.
authors.affiliation: Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, 123, Ta-Pei Road, Niao-Sung District, Kaohsiung, Taiwan, R.O.C.
authors.forename: Sheng-En
authors.initials: SE
authors.lastname: Chou
authors.forename: Chun-Ying
authors.initials: CY
authors.lastname: Huang
authors.forename: Shyr-Ming
authors.initials: SM
authors.lastname: Sheen-Chen
authors.forename: Yueh-Wei
authors.initials: YW
authors.lastname: Liu
authors.forename: Ching-Hua
authors.initials: CH
authors.lastname: Tsai
authors.forename: Yu-Hung
authors.initials: YH
authors.lastname: Lin
authors.forename: Chao-Cheng
authors.initials: CC
authors.lastname: Huang
authors.forename: Rei-Ping
authors.initials: RP
authors.lastname: Tang
mesh_terms: D000328:Adult; D000368:Aged; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism*; D064550:Death-Associated Protein Kinases; D005260:Female; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D015996:Survival Rate; D046888:Tissue Array Analysis
chemical_list: D051017:Apoptosis Regulatory Proteins; C579096:DAPK1 protein, human; D064550:Death-Associated Protein Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases