title: [Recurrent autoimmune hemolytic anemia induced by XELOX chemotherapy for colon cancer].
abstract: We describe a 54-year old woman with oxaliplatin-induced autoimmune hemolytic anemia and review the clinical features of similar published cases. The present patient had metastatic colon cancer and was admitted to our hospital with a floating sensation and general malaise on day 4 after undergoing the last of 4 cycles of a 7th round of chemotherapy with XELOX. Laboratory data revealed 4.6g/dl hemoglobin and 8.77 mg/dl creatinine. Direct and indirect Coombs tests of a blood sample for blood transfusion were both positive. We diagnosed immune hemolysis with acute renal failure based on the clinical course and blood samples showing haptoglobin <10mg/dl. We treated her with hemodialysis, plasmapheresis and immune suppression with prednisolone, which improved the anemia and renal failure.
authors.affiliation: Department of Gastroenterology, Aichi Cancer Center Hospital.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ogura
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tajika
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Niwa
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kawai
authors.forename: Shinya
authors.initials: S
authors.lastname: Kondo
authors.forename: Akira
authors.initials: A
authors.lastname: Sawaki
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Mizuno
authors.forename: Kazuo
authors.initials: K
authors.lastname: Hara
authors.forename: Susumu
authors.initials: S
authors.lastname: Hijioka
authors.forename: Masamichi
authors.initials: M
authors.lastname: Nakamura
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Higuchi
authors.forename: Hidemi
authors.initials: H
authors.lastname: Goto
authors.forename: Kenji
authors.initials: K
authors.lastname: Yamao
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000139:chemically induced*; D000970:Antineoplastic Agents / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D000069287:Capecitabine; D003110:Colonic Neoplasms / Q000188:drug therapy*; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects / Q000031:analogs & derivatives; D006801:Humans; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000009:adverse effects; D000077150:Oxaliplatin; D010071:Oxaloacetates; D012008:Recurrence
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D010071:Oxaloacetates; D000077150:Oxaliplatin; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil