title: Cardiopulmonary bypass and its direct effects on neonatal piglet kidney morphology.
abstract: Renal failure after open heart surgery is a serious complication even in the pediatric population. The aim of the present study was to analyze morphological changes after cardiopulmonary bypass (CPB) surgery in a neonatal piglet model. The kidneys of newborn piglets sacrificed 6 h after CPB were examined (CPB; n = 4) regarding tubular dilatation, vacuole formation, leukocytic infiltration, epithelial destruction, and interstitial edema. Thereafter, the findings were compared with the morphology of normal (untreated) neonatal piglet kidneys (control; n = 4). All changes but the interstitial edema were statistically significant if compared with the normal renal tissue: tubular dilatation (CPB vs. control P < 0.05), vacuole formation (CPB vs. control P < .05), leukocytic infiltration (CPB vs. control P < 0.05), and epithelial destruction (CPB vs. control P < 0.001). In conclusion, CPB induces significant changes in the morphology of the neonatal piglet kidneys.
authors.affiliation: Department for Thoracic, Cardiac, and Vascular Surgery, University of Goettingen, Goettingen, Germany. theodor.tirilomis@med.uni-goettingen.de
authors.forename: Theodor
authors.initials: T
authors.lastname: Tirilomis
authors.forename: Martin
authors.initials: M
authors.lastname: Friedrich
authors.forename: Kasim Oguz
authors.initials: KO
authors.lastname: Coskun
authors.forename: Tasso
authors.initials: T
authors.lastname: Tempes
authors.forename: Aron-Frederik
authors.initials: AF
authors.lastname: Popov
authors.forename: Jan D
authors.initials: JD
authors.lastname: Schmitto
authors.forename: Friedrich A
authors.initials: FA
authors.lastname: Schoendube
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D007668:Kidney / Q000473:pathology* / Q000648:ultrastructure; D051437:Renal Insufficiency / Q000209:etiology* / Q000473:pathology; D013552:Swine