title: Impact of endoscopic and histological evaluations of two different types of mesh plug for a groin hernia model.
abstract: OBJECTIVE
  The biological responses to mesh in vivo have been evaluated in some papers, but the in vivo condition of mesh and plugs have not been sufficiently evaluated. This study evaluated the endoscopic observations and histological assessments of mesh plugs using swine models.
  
  
  METHODS
  An artificial abdominal hernia was established in the porcine abdomen, and repaired using three different sizes of two types of plug, Proloop (ATRIUM Medical Corporation, Hudson, NH, USA) or Perfix (BARD Medical Division, Covington, GA, USA). The in vivo conditions of each plug were periodically observed using a laparoscope. Moreover, a histological evaluation of the plugs was performed 3 months after implantation.
  
  
  RESULTS
  The laparoscopic observation revealed that inversion of the plugs occurred in 10 out of 18 cases repaired with Perfix, while no case repaired with Proloop inverted. The large and medium sizes of Perfix plugs were inclined by an average of more than 30°. In addition, the triangular shape of Perfix plugs was broken and the vertical/horizontal ratio was enlarged during the observation period, while Proloop plugs shrank both vertically and horizontally. The inflammatory cell count was significantly lower within the Proloop plugs than within Perfix plugs.
  
  
  CONCLUSIONS
  Proloop plugs are apparently superior because they are stable even 3 months after implantation.
authors.affiliation: Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Mandai
authors.forename: Minoru
authors.initials: M
authors.lastname: Naito
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Hayashi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Asano
authors.forename: Hideo
authors.initials: H
authors.lastname: Ino
authors.forename: Kazunori
authors.initials: K
authors.lastname: Tsukuda
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Miyoshi
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001707:Biopsy, Needle; D004195:Disease Models, Animal; D006552:Hernia, Inguinal / Q000473:pathology* / Q000601:surgery*; D059685:Herniorrhaphy / Q000379:methods; D007150:Immunohistochemistry; D010535:Laparoscopy / Q000379:methods*; D008422:Materials Testing; D011126:Polypropylenes / Q000494:pharmacology; D011475:Prosthesis Failure; D011897:Random Allocation; D012680:Sensitivity and Specificity; D013526:Surgical Mesh; D013552:Swine
chemical_list: D011126:Polypropylenes