title: Direct effect of protein kinase C inhibitors on cardiovascular ion channels.
abstract: Protein kinase C (PKC) is a central enzyme that modulates numerous biological functions. For this reason, specific PKC inhibitors/ activators are required to study PKC-related signaling mechanisms. To date, although many PKC inhibitors have been developed, they are limited by poor selectivity and nonspecificity. In this review, we focus on the nonspecific actions of PKC inhibitors on cardiovascular ion channels in addition to their PKC-inhibiting functions. The aim of this paper is to urge caution when using PKC inhibitors to block PKC function. This information may help to better understand PKC-related physiological/biochemical studies.
authors.affiliation: Department of Physiology, Kangwon National University School of Medicine, Chuncheon 200-701, Korea
authors.forename: Youn Kyoung
authors.initials: YK
authors.lastname: Son
authors.forename: Da Hye
authors.initials: DH
authors.lastname: Hong
authors.forename: Dae-Joong
authors.initials: DJ
authors.lastname: Kim
authors.forename: Amy L
authors.initials: AL
authors.lastname: Firth
authors.forename: Won Sun
authors.initials: WS
authors.lastname: Park
mesh_terms: D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology; D007473:Ion Channels / Q000187:drug effects* / Q000378:metabolism; D008301:Maleimides / Q000737:chemistry / Q000494:pharmacology; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000201:enzymology / Q000378:metabolism*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors* / Q000378:metabolism; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D019311:Staurosporine / Q000737:chemistry / Q000494:pharmacology
chemical_list: D007211:Indoles; D007473:Ion Channels; D008301:Maleimides; D047428:Protein Kinase Inhibitors; D011493:Protein Kinase C; D019311:Staurosporine; C070515:bisindolylmaleimide I