title: Antidiabetic and antioxidant potentials of Euphorbia hirta leaves extract studied in streptozotocin-induced experimental diabetes in rats.
abstract: Euphorbia hirta, commonly known as asthma weed, is a popular folk remedy for the treatment of various ailments. Recent studies have indicated that plant has potent antioxidant properties. As part of an ongoing programme to validate the use of some reputed herbs in Indian traditional medicines, the present study was aimed to evaluate the antidiabetic and antioxidant potentials of E. hirta leaves in streptozotocin-induced experimental diabetes in rats. Oral administration of E. hirta leaves extract (300 mg/kg b.w./rat/day) for a period of 30 days indicated the antidiabetic nature of the leaves extract. Determination of the lipid peroxides, hydroperoxides, and both enzymatic and non-enzymatic antioxidants evidenced the antioxidant potential of the leaves extract. Assay of enzymes such as serum aspartate transaminase (AST), serum alanine transaminase (ALT) and serum alkaline phosphatase (ALP) revealed the non-toxic nature of E. hirta leaves. The hypoglycemic activity of the leaves extract was comparable with gliclazide, a standard reference drug.
authors.affiliation: Department of Biochemistry, University of Madras, Chennai, India. subbus2020@yahoo.co.in
authors.forename: Sorimuthu P
authors.initials: SP
authors.lastname: Subramanian
authors.forename: Subramanian
authors.initials: S
authors.lastname: Bhuvaneshwari
authors.forename: Gopalan S
authors.initials: GS
authors.lastname: Prasath
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism*; D028481:Euphorbia / Q000378:metabolism*; D005907:Gliclazide / Q000494:pharmacology; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D010936:Plant Extracts / Q000378:metabolism / Q000494:pharmacology; D018515:Plant Leaves / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000975:Antioxidants; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D013311:Streptozocin; D005907:Gliclazide