title: Highly diastereoselective and general synthesis of primary β-fluoroamines.
abstract: A short, high yielding protocol has been developed for the highly diastereoselective (dr >20:1) and general synthesis of primary β-fluoroamines by the enantioselective α-fluorination of aldehydes, conversion into the N-sulfinyl aldimine, nucleophilic addition of various organometallic species, and 1° amine liberation.
authors.affiliation: Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232, USA.
authors.forename: Michael L
authors.initials: ML
authors.lastname: Schulte
authors.forename: Craig W
authors.initials: CW
authors.lastname: Lindsley
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000588:Amines; D006845:Hydrocarbons, Fluorinated