title: Cytotoxicity and mechanical behavior of chitin-bentonite clay based polyurethane bio-nanocomposites.
abstract: Chitin based polyurethane bio-nanocomposites (PUBNC) were prepared using chitin, Delite HPS bentonite nanoclay enriched in montmorillonite (MMT), 4,4'-diphenylmethane diisocyanate (MDI) and polycaprolactone polyol CAPA 231 (3000 g/mol(-1)). The prepolymers having different concentration of Delite HPS bentonite nanoclay were extended with 2 moles of chitin. The structures of the resulted polymers were determined by FT-IR technique. The effect of nanoclay contents on mechanical properties and in vitro biocompatibility was investigated. The mechanical properties of the synthesized materials were improved with increase in the Delite HPS bentonite nanoclay contents. Optimum mechanical properties were obtained from the PU bio-nanocomposite samples having 4% Delite HPS bentonite nanoclay. The results revealed that the final PU bio-nanocomposite having 2% Delite HPS bentonite nanoclay contents is ideal contenders for surgical threads with on going investigations into their in vitro biocompatibility, non-toxicity, and mechanical properties.
authors.affiliation: Institute of Chemistry, Government College University, Faisalabad 38030, Pakistan.
authors.forename: Khalid Mahmood
authors.initials: KM
authors.lastname: Zia
authors.forename: Mohammad
authors.initials: M
authors.lastname: Zuber
authors.forename: Mehdi
authors.initials: M
authors.lastname: Barikani
authors.forename: Rizwan
authors.initials: R
authors.lastname: Hussain
authors.forename: Tahir
authors.initials: T
authors.lastname: Jamil
authors.forename: Sohail
authors.initials: S
authors.lastname: Anjum
mesh_terms: D000818:Animals; D001546:Bentonite / Q000737:chemistry*; D001672:Biocompatible Materials / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D001709:Biotechnology / Q000379:methods*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002686:Chitin / Q000737:chemistry*; D020724:Elastomers; D005347:Fibroblasts / Q000187:drug effects; D017953:Isocyanates / Q000737:chemistry; D051379:Mice; D008853:Microscopy; D053761:Nanocomposites / Q000032:analysis / Q000737:chemistry* / Q000648:ultrastructure; D011091:Polyesters / Q000737:chemistry; D011140:Polyurethanes / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D001559:Benzhydryl Compounds
chemical_list: D001546:Bentonite; D001672:Biocompatible Materials; D002686:Chitin; D020724:Elastomers; D017953:Isocyanates; D011091:Polyesters; D011140:Polyurethanes; C016240:polycaprolactone; C005969:4,4'-diphenylmethane diisocyanate; D001559:Benzhydryl Compounds