title: Emetic liability testing in ferrets.
abstract: Evidence of a candidate drug's efficacy and safety is mandatory for successful drug registration by regulatory authorities. However, a third property, tolerability, often determines a drug's acceptance by the patient population. Gastrointestinal events often determine the maximum tolerated dose in Phase I clinical trials. If the plasma concentrations achieved at the maximum tolerable dose are below those required for efficacy, the drug will certainly fail. The identification of a compound's emetic/nauseogenic liability early in the discovery process can be critical to the ultimate success of the drug discovery project. Ferrets are small carnivores (~1 kg) of the Mustelidae family that vomit in response to many pharmacological classes of drugs as well as to cytotoxic chemotherapeutics and radiation. This unit describes a simple method for evaluating the emetic and nauseogenic potential of drug candidates in ferrets.
authors.affiliation: Abbott Laboratories, Abbott Park, Illinois, USA.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Osinski
authors.forename: Terese R
authors.initials: TR
authors.lastname: Seifert
authors.forename: Thomas K
authors.initials: TK
authors.lastname: Shaughnessy
authors.forename: Gary A
authors.initials: GA
authors.lastname: Gintant
authors.forename: Bryan F
authors.initials: BF
authors.lastname: Cox
mesh_terms: D000818:Animals; D055808:Drug Discovery; D005289:Ferrets; D008297:Male; D009325:Nausea / Q000139:chemically induced*; D015203:Reproducibility of Results; D014839:Vomiting / Q000139:chemically induced*