title: Use of radiosynovectomy in recurrent warfarin-related haemarthrosis in degenerative arthritis.
abstract: Radiosynovectomy is a local and minimally invasive radiotherapy for treating various chronic inflammatory arthritis such as rheumatoid arthritis, osteoarthritis and haemophilic arthropathy. In haemophilic arthropathy, it reduces the frequency of haemarthrosis and delays the development of severe joint destruction, which ultimately requires surgical intervention. Its role in warfarin-related haemarthrosis is less clear. Haemarthrosis is an uncommon complication of warfarin use, and anticoagulation may need to be discontinued. We describe yttrium-90 radiosynovectomy use in a 74-year-old man with underlying ischaemic heart disease, atrial fibrillation, previous embolic stroke and recurrent haemarthrosis of an osteoarthritic right knee. Anticoagulation was vital and could not be permanently stopped. Due to continuing anticoagulation, he had multiple hospitalisations with recurrent right knee haemarthrosis. Intraarticular right knee yttrium-90 citrate colloid injection led to a cessation of haemarthrosis for eight months. We examined the available literature for the role of radiosynovectomy in such circumstances.
authors.affiliation: Department of Rheumatology and Immunology, Singapore General Hospital, Outram Road, Singapore 169608. yorkkiat@yahoo.com.sg
authors.forename: Y K
authors.initials: YK
authors.lastname: Tan
authors.forename: H K
authors.initials: HK
authors.lastname: Lai
authors.forename: Y Y
authors.initials: YY
authors.lastname: Chong
mesh_terms: D000368:Aged; D006395:Hemarthrosis / Q000139:chemically induced* / Q000150:complications* / Q000532:radiotherapy; D006801:Humans; D007717:Knee / Q000473:pathology; D007719:Knee Joint / Q000528:radiation effects; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D017202:Myocardial Ischemia / Q000150:complications; D010003:Osteoarthritis / Q000150:complications*; D011878:Radiotherapy / Q000379:methods*; D020521:Stroke / Q000150:complications; D013582:Synovial Fluid / Q000378:metabolism; D014859:Warfarin / Q000009:adverse effects*; D015021:Yttrium Radioisotopes / Q000494:pharmacology
chemical_list: D015021:Yttrium Radioisotopes; D014859:Warfarin