title: Analgesic and antiinflammatory activities of taxoids from Taxus wallichiana Zucc.
abstract: A study was conducted to identify constituents that might be responsible for analgesic and antiinflammatory conditions. Tasumatrol B, 1,13-diacetyl-10-deacetylbaccatin III (10-DAD) and 4-deacetylbaccatin III (4-DAB) were isolated from the bark extract of Taxus wallichiana Zucc. All the compounds were assessed for analgesic and antiinflammatory activities using an acetic acid-induced writhing model, a hot-plate test, a carrageenan-induced paw oedema model, a cotton-pellet oedema model and in vitro lipoxygenase inhibitory assay. All the compounds, especially tasumatrol B, revealed significant analgesic activity in comparison to a saline group based on an acetic acid-induced model. Similarly all of the test compounds, particularly tasumatrol B, showed significant antiinflammatory activity. However, all the compounds failed to exhibit any considerable activity in of the hot-plate test and the in vitro lipoxygenase inhibitory assay. This study has highlighted the potential of tasumatrol B to be further explored as a new lead compound for the management of pain and inflammation, one that has been discovered by scientific validation of the traditional medicinal use of T. wallichiana Zucc.
authors.affiliation: Department of Pharmacy, University of Peshawar, 25120 Pakistan.
authors.forename: Mughal
authors.initials: M
authors.lastname: Qayum
authors.forename: Muhammad
authors.initials: M
authors.lastname: Nisar
authors.forename: Muhammad Raza
authors.initials: MR
authors.lastname: Shah
authors.forename: Achyut
authors.initials: A
authors.lastname: Adhikari
authors.forename: Waqar Ahmad
authors.initials: WA
authors.lastname: Kaleem
authors.forename: Inamullah
authors.initials: I
authors.lastname: Khan
authors.forename: Nematullah
authors.initials: N
authors.lastname: Khan
authors.forename: Farah
authors.initials: F
authors.lastname: Gul
authors.forename: Ihsan Ali
authors.initials: IA
authors.lastname: Khan
authors.forename: M
authors.initials: M
authors.lastname: Zia-Ul-Haq
authors.forename: Abad
authors.initials: A
authors.lastname: Khan
mesh_terms: D019342:Acetic Acid / Q000009:adverse effects; D000700:Analgesics / Q000302:isolation & purification / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D002351:Carrageenan / Q000009:adverse effects; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D016859:Lipoxygenase Inhibitors / Q000302:isolation & purification / Q000627:therapeutic use; D008297:Male; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy; D008517:Phytotherapy; D024301:Plant Bark / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D043823:Taxoids / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D020946:Taxus / Q000737:chemistry*
chemical_list: C555562:4-deacetylbaccatin III; D000700:Analgesics; D000893:Anti-Inflammatory Agents; D016859:Lipoxygenase Inhibitors; D043823:Taxoids; C574197:tasumatrol B; D002351:Carrageenan; D019342:Acetic Acid