title: Evaluation of the new AJCC staging system for resectable hepatocellular carcinoma.
abstract: BACKGROUND
  The aim of this study was to assess the validity of the 7th edition of the American Joint Committee on Cancer (AJCC) TNM system (TNM-7) for patients undergoing hepatectomy for hepatocellular carcinoma (HCC).
  
  
  METHODS
  Partial hepatectomies performed for 879 patients from 1993 to 2005 were retrospectively reviewed. Clinicopathological factors, surgical outcome, overall survival (OS), and disease-free survival (DFS) were analyzed to evaluate the predictive value of the TNM-7 staging system.
  
  
  RESULTS
  According to the TNM-7 system, differences in five-year survival between stages I, II, and III were statistically significant. Subgroup analysis of stage III patients revealed that the difference between stages II and IIIA was not significant (OS, p = 0.246; DFS, p = 0.105). Further stratification of stages IIIA, IIIB and IIIC also did not reveal significant differences. Cox proportional hazard models of stage III analyses identified additional clinicopathological factors affecting patient survival: lack of tumor encapsulation, aspartate aminotransferase (AST) values > 68 U/L, and blood loss > 500 mL affected DFS whereas lack of tumor encapsulation, AST values > 68 U/L, blood loss > 500 mL, and serum α-fetoprotein (AFP) values > 200 ng/mL were independent factors impairing OS. Stage III factors including tumor thrombus, satellite lesions, and tumor rupture did not appear to influence survival in the stage III subgroup.
  
  
  CONCLUSIONS
  In terms of 5-year survival rates, the TNM-7 system is capable of stratifying post-hepatectomy HCC patients into stages I, II, and III but is unable to stratify stage III patients into stages IIIA, IIIB and IIIC. Lack of tumor encapsulation, AST values > 68 U/L, blood loss > 500 mL, and AFP values > 200 ng/mL are independent prognostic factors affecting long-term survival.
authors.affiliation: Department of Surgery, Chang Gung Memorial Hospital, Linkou, Chang Gung University Medical School, Taoyuan, Taiwan.
authors.forename: Chih H
authors.initials: CH
authors.lastname: Cheng
authors.forename: Chen F
authors.initials: CF
authors.lastname: Lee
authors.forename: Tsung H
authors.initials: TH
authors.lastname: Wu
authors.forename: Kun M
authors.initials: KM
authors.lastname: Chan
authors.forename: Hong S
authors.initials: HS
authors.lastname: Chou
authors.forename: Ting J
authors.initials: TJ
authors.lastname: Wu
authors.forename: Ming C
authors.initials: MC
authors.lastname: Yu
authors.forename: Tse C
authors.initials: TC
authors.lastname: Chen
authors.forename: Wei C
authors.initials: WC
authors.lastname: Lee
authors.forename: Miin F
authors.initials: MF
authors.lastname: Chen
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging / Q000592:standards*; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome