title: In vitro drug metabolism using liver microsomes.
abstract: Metabolic biotransformation of a drug can increase the rate of elimination from the body and have a significant effect on efficacy and safety. Drug candidates are screened early in the discovery process for metabolic stability using liver microsomes. Methods for microsome isolation and characterization and the determination of metabolic stability are presented.
authors.affiliation: Ricerca Biosciences, Concord, Ohio, USA.
authors.forename: Jeanette R
authors.initials: JR
authors.lastname: Hill
mesh_terms: D000818:Animals; D057166:High-Throughput Screening Assays; D006801:Humans; D008862:Microsomes, Liver / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D051381:Rats
chemical_list: D004364:Pharmaceutical Preparations