title: European dissemination of a single OXA-48-producing Klebsiella pneumoniae clone.
abstract: A Klebsiella pneumoniae isolate with decreased susceptibility to carbapenems was isolated in April 2011 in a hospital in Amsterdam (the Netherlands) and later found to be the source of an important outbreak in a Rotterdam hospital. The strain, belonging to sequence type (ST) 395, carried the bla(OXA-48) gene located onto a c 62-kb conjugative plasmid, together with the extended-spectrum β-lactamase gene bla(CTX-M-15) . It was closely related or identical to other OXA-48-positive Klebsiella pneumoniae isolates belonging to the same ST type and identified in France and Morocco. This study sheds light on the European dissemination of a single OXA-48 K. pneumoniae clone.
authors.affiliation: Service de Bactériologie-Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine et Université Paris-Sud, K. Bicêtre, France.
authors.forename: A
authors.initials: A
authors.lastname: Potron
authors.forename: J
authors.initials: J
authors.lastname: Kalpoe
authors.forename: L
authors.initials: L
authors.lastname: Poirel
authors.forename: P
authors.initials: P
authors.lastname: Nordmann
mesh_terms: D000368:Aged; D016000:Cluster Analysis; D004196:Disease Outbreaks; D005602:France / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D007710:Klebsiella Infections / Q000453:epidemiology* / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000201:enzymology* / Q000235:genetics* / Q000302:isolation & purification; D008297:Male; D017720:Molecular Epidemiology; D058889:Molecular Typing; D009018:Morocco / Q000453:epidemiology; D009426:Netherlands / Q000453:epidemiology; D010957:Plasmids / Q000032:analysis; D016133:Polymerase Chain Reaction; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
chemical_list: D001618:beta-Lactamases; C108449:oxacillinase