title: Oxidant-antioxidant imbalance in horses infected with equine infectious anaemia virus.
abstract: This study assesses the impact of equine infectious anaemia virus (EIAV) infection on the oxidant/antioxidant equilibrium of horses. Blood samples from 96 Romanian horses aged 1-25 years, were divided into different groups according to their EIAV-infection status, age, and time post-seroconversion. The effect of infection on oxidative stress was estimated by measuring enzymatic antioxidants (superoxide dismutase [SOD], glutathione peroxidase [GPx] and catalase), non-enzymatic antioxidants (uric acid and carotenoids), and lipid peroxidation (malondialdehyde [MDA]). Infection modified the oxidant/antioxidant equilibrium in the horses, influencing GPx and uric acid levels (P<0.05). Time post-seroconversion also contributed to oxidative stress imbalance, exhibiting a significant influence on both SOD and MDA concentrations in the blood (P<0.05). Animal age did not have a significant influence on oxidative stress. Recently infected horses (<1 year following seroconversion), and horses >5 years old, represented the most vulnerable category in terms of oxidative stress, followed by recently infected animals <5 years old. The results of this study are novel in implicating EIAV infection in the development of oxidative stress in horses.
authors.affiliation: Department of Pathology, Faculty of Veterinary Medicine, USAMV, Calea Mănăştur 3-5, Cluj-Napoca 400372, Romania. pompeibolfa@gmail.com
authors.forename: Pompei Florin
authors.initials: PF
authors.lastname: Bolfă
authors.forename: Caroline
authors.initials: C
authors.lastname: Leroux
authors.forename: Adela
authors.initials: A
authors.lastname: Pintea
authors.forename: Sanda
authors.initials: S
authors.lastname: Andrei
authors.forename: Cornel
authors.initials: C
authors.lastname: Cătoi
authors.forename: Marian
authors.initials: M
authors.lastname: Taulescu
authors.forename: Flaviu
authors.initials: F
authors.lastname: Tăbăran
authors.forename: Marina
authors.initials: M
authors.lastname: Spînu
mesh_terms: D000375:Aging; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D004859:Equine Infectious Anemia / Q000097:blood / Q000378:metabolism*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood / Q000378:metabolism; D006736:Horses; D004860:Infectious Anemia Virus, Equine / Q000502:physiology*; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D016877:Oxidants / Q000097:blood*; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism; D013997:Time Factors
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D016877:Oxidants; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase