title: Stereotactic radiosurgery for spinal metastases: update on treatment strategies.
abstract: Metastatic tumors are the most common tumors that affect the spinal column and are the source of significant pain and disability in cancer patients. The management of symptomatic spinal metastases presents unique challenges to surgeons as a number of considerations specific to the underlying tumor histology, extent of disease, the functional status of the patient and response to systemic therapy often affect the role, timing and effectiveness of any surgical intervention. As surgical techniques have evolved, the focus of therapy has shifted towards minimizing the morbidity associated with treatments for patients in whom limited nutrition and functional reserve impact their overall survival. As such, stereotactic spinal radiosurgery (SRS) has emerged as a powerful adjunct to surgery as well as a stand-alone treatment option for patients with metastatic disease. Recent technological innovations such as intensity-modulated radiation therapy, image-guidance, and non-invasive spine immobilization have made significant improvements to the delivery of highly conformal radiation to spinal tumors. In this article, current treatment strategies utilizing SRS in the multidisciplinary management of spinal metastases are discussed.
authors.affiliation: Department of Neurosurgery, Harvard Medical School, Boston, MA, USA. johnhongshin@gmail.com
authors.forename: J H
authors.initials: JH
authors.lastname: Shin
authors.forename: S T
authors.initials: ST
authors.lastname: Chao
authors.forename: L
authors.initials: L
authors.lastname: Angelov
mesh_terms: D000328:Adult; D002292:Carcinoma, Renal Cell / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000379:methods / Q000639:trends*; D016634:Radiosurgery / Q000379:methods / Q000639:trends*; D013125:Spinal Neoplasms / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery*; D001749:Urinary Bladder Neoplasms / Q000473:pathology