title: Abenquines A-D: aminoquinone derivatives produced by Streptomyces sp. strain DB634.
abstract: New bioactive secondary metabolites, called abenquines, were found in the fermentation broth of Streptomyces sp. strain DB634, which was isolated from the soils of the Chilean highland of the Atacama Desert. They are composed of an amino acid linked to an N-acetyl-aminobenzoquinone. Isolation of the abenquines (1-4), their structure elucidation by NMR analysis and MS, as well as the kinetics of their production are presented. The abenquines show inhibitory activity against bacteria, dermatophytic fungi and phosphodiesterase type 4b. The amino acid attached to the quinone is relevant to the enzyme inhibitory activity.
authors.affiliation: Kieler Wirkstoff-Zentrum at the Leibniz-Institute of Marine Sciences (IFM-GEOMAR), Kiel, Germany.
authors.forename: Dirk
authors.initials: D
authors.lastname: Schulz
authors.forename: Pascal
authors.initials: P
authors.lastname: Beese
authors.forename: Birgit
authors.initials: B
authors.lastname: Ohlendorf
authors.forename: Arlette
authors.initials: A
authors.lastname: Erhard
authors.forename: Heidi
authors.initials: H
authors.lastname: Zinecker
authors.forename: Cristina
authors.initials: C
authors.lastname: Dorador
authors.forename: Johannes F
authors.initials: JF
authors.lastname: Imhoff
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002677:Chile; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4 / Q000378:metabolism; D003889:Desert Climate; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D051379:Mice; D008826:Microbial Sensitivity Tests; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism* / Q000494:pharmacology; D012988:Soil Microbiology; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D004791:Enzyme Inhibitors; D011809:Quinones; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4