title: Childhood epidermolysis bullosa acquisita: report of a Chinese case.
abstract: Epidermolysis bullosa acquisita (EBA) is a rare, acquired, subepidermal blistering disease characterized by autoantibodies directed against type VII collagen, the major component of anchoring fibrils. We report a 5-year-old Chinese boy who presented with extensive lesions consisting of disseminated pruritic vesicles and tense blisters. The diagnosis of EBA was confirmed by histopathology, immunofluorescence, and immunoblotting analysis. The disease was controlled with a combination of prednisone and dapsone.
authors.affiliation: Shandong Provincial Institute of Dermatology and Venereology, Shandong Provincial Academy of Medical Science, Jinan, China.
authors.forename: Baoqi
authors.initials: B
authors.lastname: Yang
authors.forename: Chong
authors.initials: C
authors.lastname: Wang
authors.forename: Na
authors.initials: N
authors.lastname: Wang
authors.forename: Futang
authors.initials: F
authors.lastname: Pan
authors.forename: Shengli
authors.initials: S
authors.lastname: Chen
authors.forename: Guizhi
authors.initials: G
authors.lastname: Zhou
authors.forename: Meiling
authors.initials: M
authors.lastname: Yu
authors.forename: Furen
authors.initials: F
authors.lastname: Zhang
mesh_terms: D044466:Asian People; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D001485:Basement Membrane / Q000276:immunology; D002675:Child, Preschool; D024143:Collagen Type VII / Q000276:immunology; D003622:Dapsone / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D016107:Epidermolysis Bullosa Acquisita / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D005455:Fluorescent Antibody Technique; D006801:Humans; D015151:Immunoblotting; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies; D024143:Collagen Type VII; D003879:Dermatologic Agents; D003622:Dapsone; D011241:Prednisone