title: A brief history of error.
abstract: The spindle checkpoint monitors chromosome alignment on the mitotic and meiotic spindle. When the checkpoint detects errors, it arrests progress of the cell cycle while it attempts to correct the mistakes. This perspective will present a brief history summarizing what we know about the checkpoint, and a list of questions we must answer before we understand it.
authors.affiliation: Harvard University, Molecular and Cellular Biology, 52 Oxford Street, Northwest Science Building, Cambridge, Massachusetts 02138, USA. awm@mcb.harvard.edu
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Murray
mesh_terms: D000818:Animals; D003585:Cell Biology / Q000266:history*; D002453:Cell Cycle / Q000235:genetics; D059447:Cell Cycle Checkpoints; D002875:Chromosomes / Q000378:metabolism; D004249:DNA Damage; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D015398:Signal Transduction; D008941:Spindle Apparatus / Q000378:metabolism