title: Urinary excretion of liver-type fatty acid-binding protein as a marker of progressive kidney function deterioration in patients with chronic glomerulonephritis.
abstract: BACKGROUND
  To evaluate the value of basal urinary L-FABP (uL-FABP) excretion as a prognostic indicator of the progression of kidney function impairment in patients with chronic glomerulonephritis (CGN).
  
  
  METHODS
  One hundred twenty-three patients with newly diagnosed, biopsy-proven primary CGN were included. In all patients, and in 28 healthy subjects, uL-FABP was measured using an ELISA. Risk factors of the progression of kidney function were evaluated. The patients were in follow-up for at least 5 years.
  
  
  RESULTS
  uL-FABP in the patients with CGN (76.58±17.3 μg/g.cr) was greater than in the healthy subjects. A significant positive correlation between uL-FABP and proteinuria (R=0.501, P<0.01), serum creatinine (R=0.601, P<0.01) were found. Kaplan-Meier analysis revealed that uL-FABP >76.58 μg/g.cr predicts progression of renal function. The cut off values for L-FABP at 119.8 μg/g.cr was found to be more sensitive, area under the curve (AUC) was 0.95.
  
  
  CONCLUSIONS
  Urinary L-FABP may be a useful clinical biomarker for monitoring chronic glomerular disease. Urinary L-FABP can help predict the progression of chronic glomerular disease.
authors.affiliation: Renal Division, Renji Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, PR China. shan_mou@126.com
authors.forename: Shan
authors.initials: S
authors.lastname: Mou
authors.forename: Qin
authors.initials: Q
authors.lastname: Wang
authors.forename: Jialin
authors.initials: J
authors.lastname: Li
authors.forename: Beili
authors.initials: B
authors.lastname: Shi
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Ni
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000652:urine*; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D050556:Fatty Acid-Binding Proteins / Q000652:urine*; D005260:Female; D005921:Glomerulonephritis / Q000503:physiopathology* / Q000652:urine; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D050556:Fatty Acid-Binding Proteins