title: Success rates of a mixture of ciprofloxacin, metronidazole, and minocycline antibiotics used in the non-instrumentation endodontic treatment of mandibular primary molars with carious pulpal involvement.
abstract: OBJECTIVE
  To evaluate the clinical and radiographic success rates of three mixed antibiotics in the non-instrumentation endodontic treatment of primary mandibular molars at 24-27 months postoperatively.
  
  
  METHODS
  Eighty cariously involved lower primary molars from 58 children (ages 3-8 years) received a 3Mix medicament by non-instrumentation endodontic treatment and were then sealed with glass-ionomer cement and composite resin before permanent restoration with stainless steel crowns. The patients received a clinical and radiographic assessment every 6 months over a 2-year follow-up period with an intra-examiner reliability of 0.83-1.00 (κ value).
  
  
  RESULTS
  In 60 cases at 24- to 27-month follow-up, the success rates as determined by clinical and radiographic evaluation were 75% and 36.7%, respectively; however, the overall success rate of 3Mix non-instrumentation endodontic treatment was 36.7% with 15.8% of cases demonstrating a pulpal response of internal resorption.
  
  
  CONCLUSIONS
  Non-instrumentation endodontic treatment using 3Mix-MP showed good clinical success but had a low success rate based on radiographic evaluation at 2-year follow-up. Hence, 3Mix antibiotic treatment cannot replace a conventional root canal treatment agent as a long-term therapy.
authors.affiliation: Department of Pediatric Dentistry, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Chutima
authors.initials: C
authors.lastname: Trairatvorakul
authors.forename: Palinee
authors.initials: P
authors.lastname: Detsomboonrat
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D017438:Bisphenol A-Glycidyl Methacrylate / Q000737:chemistry; D002648:Child; D002675:Child, Preschool; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D003188:Composite Resins / Q000737:chemistry; D003442:Crowns; D003722:Dental Alloys / Q000737:chemistry; D003731:Dental Caries / Q000628:therapy*; D003764:Dental Materials / Q000737:chemistry; D003789:Dental Pulp Exposure / Q000628:therapy; D003790:Dental Pulp Necrosis / Q000628:therapy; D004338:Drug Combinations; D005500:Follow-Up Studies; D005899:Glass Ionomer Cements / Q000737:chemistry; D006801:Humans; D008334:Mandible; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008911:Minocycline / Q000008:administration & dosage / Q000627:therapeutic use*; D008963:Molar / Q000473:pathology*; D010755:Organophosphates / Q000737:chemistry; D011672:Pulpotomy / Q000379:methods*; D016300:Radiography, Bitewing; D012117:Resins, Synthetic / Q000737:chemistry; D012388:Root Canal Irrigants / Q000627:therapeutic use; D013193:Stainless Steel / Q000737:chemistry; D014094:Tooth, Deciduous / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: C489661:Adper Prompt Self-Etch; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D003188:Composite Resins; D003722:Dental Alloys; D003764:Dental Materials; D004338:Drug Combinations; C444701:Filtek Z250; C079765:Fuji II LC cement; D005899:Glass Ionomer Cements; D010755:Organophosphates; D012117:Resins, Synthetic; D012388:Root Canal Irrigants; D013193:Stainless Steel; D008795:Metronidazole; D017438:Bisphenol A-Glycidyl Methacrylate; D002939:Ciprofloxacin; D008911:Minocycline