title: Multimodal MRI assessment of damage and plasticity caused by status epilepticus in the rat brain.
abstract: Status epilepticus or other brain-damaging insults launch a cascade of events that may lead to the development of epilepsy. MRI techniques available today, including T(2) - and T(1) -weighted imaging, functional MRI, manganese enhanced MRI (MEMRI), arterial spin labeling (ASL), diffusion tensor imaging (DTI), and phase imaging, can detect not only damage caused by status epilepticus but also plastic changes in the brain that occur in response to damage. Optimal balance between damage and recovery processes is a key for planning possible treatments, and noninvasive imaging has the potential to greatly facilitate this process and to make personalized treatment plans possible.
authors.affiliation: Biomedical NMR Research Group Epilepsy Research Laboratory, Department of Neurobiology, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland. olli.grohn@uef.fi
authors.forename: Olli
authors.initials: O
authors.lastname: Gröhn
authors.forename: Alejandra
authors.initials: A
authors.lastname: Sierra
authors.forename: Riikka
authors.initials: R
authors.lastname: Immonen
authors.forename: Teemu
authors.initials: T
authors.lastname: Laitinen
authors.forename: Kimmo
authors.initials: K
authors.lastname: Lehtimäki
authors.forename: Antti
authors.initials: A
authors.lastname: Airaksinen
authors.forename: Nick
authors.initials: N
authors.lastname: Hayward
authors.forename: Jaak
authors.initials: J
authors.lastname: Nairismagi
authors.forename: Lauri
authors.initials: L
authors.lastname: Lehto
authors.forename: Asla
authors.initials: A
authors.lastname: Pitkänen
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology* / Q000503:physiopathology*; D001929:Brain Edema / Q000209:etiology / Q000473:pathology; D001930:Brain Injuries / Q000150:complications; D001931:Brain Mapping; D004195:Disease Models, Animal; D008279:Magnetic Resonance Imaging; D009473:Neuronal Plasticity; D051381:Rats; D013226:Status Epilepticus / Q000209:etiology / Q000473:pathology*