title: Synthesis of new pyrroles of potential anti-inflammatory activity.
abstract: We herein disclose a series of novel pyrrole derivatives 1-4 and pyrrolo[2,3-d]pyrimidine derivatives 6-11 as novel potent anti-inflammatory compounds. The structures were confirmed by IR, (1) H-NMR, and MS. Some newly synthesized compounds were examined for their in-vivo anti-inflammatory activity. Several derivatives showed a promising anti-inflammatory activity compared to ibuprofen. In this paper, we examine and discuss the structure-activity relationships and anti-inflammatory activities of these compounds.
authors.affiliation: Pharmaceutical Organic Chemistry Department, Helwan University, Ein Helwan, Cairo, Egypt.
authors.forename: Mosaad S
authors.initials: MS
authors.lastname: Mohamed
authors.forename: Rehab
authors.initials: R
authors.lastname: Kamel
authors.forename: Samar S
authors.initials: SS
authors.lastname: Fathallah
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; D011758:Pyrroles