title: Common-path low-coherence interferometry fiber-optic sensor guided microincision.
abstract: We propose and demonstrate a common-path low-coherence interferometry (CP-LCI) fiber-optic sensor guided precise microincision. The method tracks the target surface and compensates the tool-to-surface relative motion with better than ± 5 μm resolution using a precision micromotor connected to the tool tip. A single-fiber distance probe integrated microdissector was used to perform an accurate 100 μm incision into the surface of an Intralipid phantom. The CP-LCI guided incision quality in terms of depth was evaluated afterwards using three-dimensional Fourier-domain optical coherence tomography imaging, which showed significant improvement of incision accuracy compared to free-hand-only operations.
authors.affiliation: Johns Hopkins University, Department of Electrical and Computer Engineering, Baltimore, Maryland 21218, USA. kangzhang2011@gmail.com
authors.forename: Kang
authors.initials: K
authors.lastname: Zhang
authors.forename: Jin U
authors.initials: JU
authors.lastname: Kang
mesh_terms: D004655:Emulsions; D004867:Equipment Design; D005336:Fiber Optic Technology / Q000295:instrumentation*; D005583:Fourier Analysis; D007368:Interferometry / Q000379:methods*; D042282:Microdissection; D008866:Microsurgery / Q000295:instrumentation* / Q000379:methods*; D008954:Models, Biological; D019047:Phantoms, Imaging; D010743:Phospholipids; D013024:Soybean Oil; D025321:Surgery, Computer-Assisted / Q000379:methods*; D041623:Tomography, Optical Coherence / Q000379:methods*
chemical_list: D004655:Emulsions; D010743:Phospholipids; C545823:soybean oil, phospholipid emulsion; D013024:Soybean Oil