title: Antimalarial activity of physalins B, D, F, and G.
abstract: The antimalarial activities of physalins B, D, F, and G (1-4), isolated from Physalis angulata, were investigated. In silico analysis using the similarity ensemble approach (SEA) database predicted the antimalarial activity of each of these compounds, which were shown using an in vitro assay against Plasmodium falciparum. However, treatment of P. berghei-infected mice with 3 increased parasitemia levels and mortality, whereas treatment with 2 was protective, causing a parasitemia reduction and a delay in mortality in P. berghei-infected mice. The exacerbation of in vivo infection by treatment with 3 is probably due to its potent immunosuppressive activity, which is not evident for 2.
authors.affiliation: Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia, Brazil.
authors.forename: Matheus S
authors.initials: MS
authors.lastname: Sá
authors.forename: Maria N
authors.initials: MN
authors.lastname: de Menezes
authors.forename: Antoniana U
authors.initials: AU
authors.lastname: Krettli
authors.forename: Ivone M
authors.initials: IM
authors.lastname: Ribeiro
authors.forename: Therezinha C B
authors.initials: TC
authors.lastname: Tomassini
authors.forename: Ricardo
authors.initials: R
authors.lastname: Ribeiro dos Santos
authors.forename: Walter F
authors.initials: WF
authors.lastname: de Azevedo
authors.forename: Milena B P
authors.initials: MB
authors.lastname: Soares
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008288:Malaria / Q000188:drug therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D018512:Parasitemia / Q000188:drug therapy; D032321:Physalis / Q000737:chemistry*; D010962:Plasmodium berghei / Q000187:drug effects*; D010963:Plasmodium falciparum / Q000187:drug effects*; D012632:Secosteroids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000962:Antimalarials; D007166:Immunosuppressive Agents; D012632:Secosteroids; C441429:physalin D; C569084:physalin G; C033270:physalin B; C075425:physalin F