title: Improvement of sodium status to optimize the efficacy of Renin-Angiotensin system blockade.
abstract: Blockade of the renin-angiotensin-aldosterone system (RAAS) offers superior renoprotection in the treatment of patients with hypertension, but the efficacy of RAAS inhibition strongly depends on sodium status, presumably in relation to extracellular volume status. Because assessing volume status by physical examination is challenging, 24-hour urine collection and NT-proBNP levels are useful tools for guiding volume management and achieving sodium status targets.
authors.affiliation: Department of Internal Medicine, Division of Nephrology, ZGT Hospital Almelo, Almelo, The Netherlands.
authors.forename: Gozewijn D
authors.initials: GD
authors.lastname: Laverman
authors.forename: Gerjan
authors.initials: G
authors.lastname: Navis
mesh_terms: D005110:Extracellular Space / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007676:Kidney Failure, Chronic / Q000517:prevention & control*; D020097:Natriuretic Peptide, Brain / Q000652:urine; D009752:Nutritional Status; D010446:Peptide Fragments / Q000652:urine; D012084:Renin-Angiotensin System / Q000187:drug effects* / Q000502:physiology; D012964:Sodium / Q000378:metabolism*; D012982:Sodium, Dietary
chemical_list: D010446:Peptide Fragments; D012982:Sodium, Dietary; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D012964:Sodium