title: Melanosis of the vagina and human papillomavirus infection, an uncommon pathology: case report.
abstract: Benign melanotic lesions of the vagina are uncommon and only a few cases have been reported in the literature. A 34-year-old woman was referred because of a Vaginal Intraepithelial Neoplasia 1 biopsy result. On the gynecological examination, two different hyperpigmented areas were noted in the vagina. The colposcopic visualization of the cervix and vagina found an aceto-white lesion at the right lateral wall of the upper third of the vagina. Biopsies from three areas were taken. Histological study reported a melanosis of the vagina and HPV infection. An immunohistochemical panel of epithelial markers was performed in vaginal samples, such as Cytokeratin AE1/AE3 and epithelial membrane antigen, mesenchymal marker: vimentin; melanocytic makers: protein S-100 and HMB45 (Human Melanoma Black); proliferating cell marker: proliferating cell nuclear antigen (PCNA), and P-53 oncoprotein. High Risk (16, 18, 31, 45) and Low Risk (6, 11) HPV types were studied by In Situ Hybridization using the same vaginal samples. CK, EMA and Vimentin were 2+. Melanocytic markers, HMB45 and S100, and PCNA were 1+ in basal cell layer. P-53 was negative. The melanotic tissue and acetowhite lesion were positives to HPV Types 6,11. In conclusion, melanosis of the vagina is a uncommon benign pathology. Usually, melanosis is present in women over 40 years old. We present a case of melanosis of the vagina in a young woman infected with low-risk HPV types and review the literature.
authors.affiliation: Department of Obstetrics and Gynecology, Hospital Manuel Noriega Trigo, Universidad del Zulia. jtnunezt@gmail.com
authors.forename: José
authors.initials: J
authors.lastname: Núñez-Troconis
authors.forename: Mariela
authors.initials: M
authors.lastname: Delgado
authors.forename: Gerardo
authors.initials: G
authors.lastname: González
authors.forename: Airiaudis
authors.initials: A
authors.lastname: Rivas
authors.forename: Katherine
authors.initials: K
authors.lastname: Molero
mesh_terms: D019342:Acetic Acid; D000328:Adult; D015415:Biomarkers; D003127:Colposcopy; D003218:Condylomata Acuminata / Q000473:pathology* / Q000821:virology; D003937:Diagnosis, Differential; D005260:Female; D052140:Human papillomavirus 11 / Q000302:isolation & purification* / Q000472:pathogenicity; D052163:Human papillomavirus 6 / Q000302:isolation & purification* / Q000472:pathogenicity; D006801:Humans; D008545:Melanoma / Q000175:diagnosis; D008548:Melanosis / Q000175:diagnosis / Q000209:etiology* / Q000821:virology; D030361:Papillomavirus Infections / Q000473:pathology* / Q000821:virology; D011230:Precancerous Conditions / Q000473:pathology / Q000821:virology; D014625:Vaginal Neoplasms / Q000175:diagnosis; D014627:Vaginitis / Q000175:diagnosis / Q000473:pathology* / Q000821:virology
chemical_list: D015415:Biomarkers; D019342:Acetic Acid