title: A practical, convergent route to the key precursor to the tetracycline antibiotics.
abstract: Here we describe a 5-step sequence to prepare the AB enone 1, the key precursor to fully synthetic tetracyclines, that begins with a diastereoselective Michael-Claisen coupling of two simple starting materials, a cyclohexenone (compound 2 or, in a refinement, a substituted variant, vide infra) and the isoxazole ester 3. This advance defines an 8-step linear sequence to 6-deoxytetracycline antibiotics from three components of similar complexity (cyclohexenone 2, isoxazole ester 3, and structurally diverse D-ring precursors) in which sequential diastereoselective Michael-Claisen cyclization reactions form the A- and C-rings, respectively, of the linearly fused ABCD tetracycline skeleton. In addition to providing a readily scalable, practical route to fully synthetic tetracyclines of broad structural diversity, the sequence reported comprises a series of non-obvious stereoselective transformations, including a novel means for C12a hydroxylation.
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, 02138, USA.  myers@chemistry.harvard.edu ; ; Tel: +1-617-495-5679.
authors.forename: David A
authors.initials: DA
authors.lastname: Kummer
authors.forename: Derun
authors.initials: D
authors.lastname: Li
authors.forename: Amelie
authors.initials: A
authors.lastname: Dion
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Myers