title: MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis.
abstract: Dysregulation of the T cell-dependent Ab response can lead to numerous immunological disorders, ranging from systemic lupus erythematosus to B cell lymphomas. Cellular processes governed by MHC class II proteins play a major role in this response and its dysregulation. The extent to which processes controlled by the diverse family of MHC class I proteins impact such autoimmune and neoplastic disorders, however, is less clear. In this study, we genetically dissect the contributions of individual MHC class I family members and the pathological processes under their control in the systemic lupus erythematosus-like disease of BXSB.Yaa mice and B cell lymphomagenesis of SJL mice. This study reveals a powerful repressive regulatory axis comprised of MHC class I-dependent CD8(+) T cells and NK cells. These results indicate that the predominant role of the MHC class I protein family in such immunological disorders is to protect from more aggressive diseases.
authors.affiliation: The Jackson Laboratory, Bar Harbor, ME 04609, USA.
authors.forename: Caroline G
authors.initials: CG
authors.lastname: McPhee
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Sproule
authors.forename: Dong-Mi
authors.initials: DM
authors.lastname: Shin
authors.forename: Jason A
authors.initials: JA
authors.lastname: Bubier
authors.forename: William H
authors.initials: WH
authors.lastname: Schott
authors.forename: Martin P
authors.initials: MP
authors.lastname: Steinbuck
authors.forename: Lia
authors.initials: L
authors.lastname: Avenesyan
authors.forename: Herbert C
authors.initials: HC
authors.lastname: Morse
authors.forename: Derry C
authors.initials: DC
authors.lastname: Roopenian
mesh_terms: D000818:Animals; D016175:B-Lymphocyte Subsets / Q000276:immunology* / Q000473:pathology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology; D006183:H-2 Antigens / Q000235:genetics; D064532:Histocompatibility Antigen H-2D; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000502:physiology*; D007694:Killer Cells, Natural / Q000276:immunology / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology* / Q000401:mortality / Q000517:prevention & control*; D016393:Lymphoma, B-Cell / Q000276:immunology* / Q000401:mortality / Q000517:prevention & control*; D051379:Mice; D008815:Mice, Inbred Strains; D008979:Moloney murine leukemia virus / Q000276:immunology; D001613:beta 2-Microglobulin / Q000172:deficiency / Q000235:genetics
chemical_list: D006183:H-2 Antigens; C024755:H-2K(K) antigen; D064532:Histocompatibility Antigen H-2D; D015395:Histocompatibility Antigens Class I; D001613:beta 2-Microglobulin