title: Awara (Astrocaryum vulgare M.) pulp oil: chemical characterization, and anti-inflammatory properties in a mice model of endotoxic shock and a rat model of pulmonary inflammation.
abstract: Awara (Astrocaryum vulgare M.) is a palm fruit mainly used in nutrition. We analysed the pulp oil for fatty acid, tocopherol, carotenoid, and phytosterol and we evaluated whether this oil may attenuate inflammation in vivo. In an endotoxic shock model, awara pulp oil treatment decreased pro-inflammatory cytokines and increased anti-inflammatory cytokines. In a pulmonary inflammation model, awara pulp oil treatment reduced eosinophil and lymphocyte numbers recovered into the broncho-alveolar lavages. These results suggest that awara pulp oil administration can efficiently counteract an acute and chronic inflammatory response in vivo that is probably mediated by fatty acids and minor compounds.
authors.affiliation: Laboratoire de Pharmacologie et Physiopathologie Expérimentales, UMR Qualisud, Faculté de Pharmacie, Université Montpellier I, 15 avenue Charles Flahault, 34093 Montpellier Cedex 5, France. bony.emilie@free.fr
authors.forename: Emilie
authors.initials: E
authors.lastname: Bony
authors.forename: Frédéric
authors.initials: F
authors.lastname: Boudard
authors.forename: Pierre
authors.initials: P
authors.lastname: Brat
authors.forename: Emilie
authors.initials: E
authors.lastname: Dussossoy
authors.forename: Karine
authors.initials: K
authors.lastname: Portet
authors.forename: Patrick
authors.initials: P
authors.lastname: Poucheret
authors.forename: Jean
authors.initials: J
authors.lastname: Giaimis
authors.forename: Alain
authors.initials: A
authors.lastname: Michel
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D028023:Arecaceae / Q000737:chemistry*; D002338:Carotenoids / Q000737:chemistry; D005227:Fatty Acids / Q000737:chemistry; D008070:Lipopolysaccharides / Q000633:toxicity; D008171:Lung Diseases / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology; D010840:Phytosterols / Q000737:chemistry; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D012772:Shock, Septic / Q000139:chemically induced / Q000188:drug therapy*; D024505:Tocopherols / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D005227:Fatty Acids; D008070:Lipopolysaccharides; D010840:Phytosterols; D010938:Plant Oils; D002338:Carotenoids; D010047:Ovalbumin; D024505:Tocopherols