title: Febrile infection-related epilepsy syndrome (FIRES): does duration of anesthesia affect outcome?
abstract: We conducted a retrospective multicenter study on children who had been included in eight studies published between November 2001 and July 2010 to explore the correlations between burst-suppression coma (BSC) with outcome in febrile infection-related epilepsy syndrome (FIRES). The 77 enrolled patients presented with prolonged refractory status epilepticus. BSC was induced in 46 patients. Cognitive levels at follow-up were significantly associated with duration of a BSC (p=0.005). The outcome of FIRES is poor. Treatment by inducing a prolonged BSC was associated with a worse cognitive outcome.
authors.affiliation: Pediatric Epilepsy Unit, Tel Aviv Sourasky Medical Center, Tel Aviv University, 6 Weitzman Street, Tel Aviv, Israel. umkramer@netvision.net.il
authors.forename: Uri
authors.initials: U
authors.lastname: Kramer
authors.forename: Ching-Shiang
authors.initials: CS
authors.lastname: Chi
authors.forename: Kuang-Lin
authors.initials: KL
authors.lastname: Lin
authors.forename: Nicola
authors.initials: N
authors.lastname: Specchio
authors.forename: Mustafa
authors.initials: M
authors.lastname: Sahin
authors.forename: Heather
authors.initials: H
authors.lastname: Olson
authors.forename: Gerhard
authors.initials: G
authors.lastname: Kluger
authors.forename: Andreas
authors.initials: A
authors.lastname: van Baalen
mesh_terms: D000758:Anesthesia / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D003072:Cognition Disorders / Q000209:etiology; D003128:Coma / Q000139:chemically induced / Q000503:physiopathology; D004660:Encephalitis / Q000150:complications; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D003294:Seizures, Febrile / Q000209:etiology / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome