title: Proton pump inhibitor use in infants:  FDA reviewer experience.
abstract: The Food and Drug Administration has completed its review of 4 clinical trials evaluating the use of proton pump inhibitors (PPIs) in infants (ages 1 month to <12 months) for the treatment of gastroesophageal reflux disease (GERD). An Advisory Committee meeting was held in November 2010 to discuss the potential reasons why PPI use in these trials failed to show a benefit in infants with GERD, and directions for future study. The present review summarizes the findings from the clinical trials. Potential mechanisms for the failed clinical trials are discussed. The safety of long-term use is also discussed. As a result of our analysis and review, the authors agree with the Advisory Committee members that PPIs should not be administered to treat the symptoms of GERD in the otherwise healthy infant without the evidence of acid-induced disease.
authors.affiliation: Division of Gastroenterology and Inborn Errors Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993-0002, USA.
authors.forename: Ii-Lun
authors.initials: IL
authors.lastname: Chen
authors.forename: Wen-Yi
authors.initials: WY
authors.lastname: Gao
authors.forename: Aisha P
authors.initials: AP
authors.lastname: Johnson
authors.forename: Ali
authors.initials: A
authors.lastname: Niak
authors.forename: John
authors.initials: J
authors.lastname: Troiani
authors.forename: Joyce
authors.initials: J
authors.lastname: Korvick
authors.forename: Nancy
authors.initials: N
authors.lastname: Snow
authors.forename: Kristina
authors.initials: K
authors.lastname: Estes
authors.forename: Amy
authors.initials: A
authors.lastname: Taylor
authors.forename: Donna
authors.initials: D
authors.lastname: Griebel
mesh_terms: D026683:Advisory Committees; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D017063:Outcome Assessment, Health Care; D054328:Proton Pump Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D017211:Treatment Failure; D014481:United States; D014486:United States Food and Drug Administration
chemical_list: D054328:Proton Pump Inhibitors