title: First face composite-tissue transplant recipient successfully treated for cytomegalovirus infection with preemptive valganciclovir treatment.
abstract: Little is known about cytomegalovirus (CMV) infection after face transplantation, since only two of the 11 cases of face transplantation reported worldwide have documented a CMV infection after transplantation. Herein, we present the first report of a composite-tissue face allotransplant recipient at high risk for CMV infection (D(+)/R(-) [CMV serpositive donor positive/CMV seronegative receptor]) undergoing preemptive treatment. Preemptive treatment was safe and effective for controlling CMV infection and thus promoting early acquisition of a CMV-specific immune response that protected the patient from late-onset CMV disease.
authors.affiliation: Unit of Infectious Diseases, Microbiology and Preventive Medicine/Instituto de Biomedicina de Sevilla, University Hospital Virgen del Rocío/CSIC/University of Sevilla, Seville, Spain.
authors.forename: O J
authors.initials: OJ
authors.lastname: BenMarzouk-Hidalgo
authors.forename: E
authors.initials: E
authors.lastname: Cordero
authors.forename: T
authors.initials: T
authors.lastname: Gómez-Cía
authors.forename: M
authors.initials: M
authors.lastname: Sánchez
authors.forename: J D
authors.initials: JD
authors.lastname: González-Padilla
authors.forename: P
authors.initials: P
authors.lastname: Infante-Cossio
authors.forename: D
authors.initials: D
authors.lastname: Sicilia-Castro
authors.forename: J M
authors.initials: JM
authors.lastname: Hernández-Guisado
authors.forename: P
authors.initials: P
authors.lastname: Pérez-Romero
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D003587:Cytomegalovirus / Q000187:drug effects; D003586:Cytomegalovirus Infections / Q000188:drug therapy* / Q000821:virology; D054445:Facial Transplantation / Q000009:adverse effects*; D015774:Ganciclovir / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000188:drug therapy; D016896:Treatment Outcome; D000077562:Valganciclovir
chemical_list: D000998:Antiviral Agents; D000077562:Valganciclovir; D015774:Ganciclovir