title: microRNA-34c is a novel target to treat dementias.
abstract: MicroRNAs are key regulators of transcriptome plasticity and have been implicated with the pathogenesis of brain diseases. Here, we employed massive parallel sequencing and provide, at an unprecedented depth, the complete and quantitative miRNAome of the mouse hippocampus, the prime target of neurodegenerative diseases such as Alzheimer's disease (AD). Using integrative genetics, we identify miR-34c as a negative constraint of memory consolidation and show that miR-34c levels are elevated in the hippocampus of AD patients and corresponding mouse models. In line with this, targeting miR-34 seed rescues learning ability in these mouse models. Our data suggest that miR-34c could be a marker for the onset of cognitive disturbances linked to AD and indicate that targeting miR-34c could be a suitable therapy.
authors.affiliation: Laboratory for Aging and Cognitive Diseases, European Neuroscience Institute, Göttingen, Germany.
authors.forename: Athanasios
authors.initials: A
authors.lastname: Zovoilis
authors.forename: Hope Y
authors.initials: HY
authors.lastname: Agbemenyah
authors.forename: Roberto C
authors.initials: RC
authors.lastname: Agis-Balboa
authors.forename: Roman M
authors.initials: RM
authors.lastname: Stilling
authors.forename: Dieter
authors.initials: D
authors.lastname: Edbauer
authors.forename: Pooja
authors.initials: P
authors.lastname: Rao
authors.forename: Laurent
authors.initials: L
authors.lastname: Farinelli
authors.forename: Ivana
authors.initials: I
authors.lastname: Delalle
authors.forename: Andrea
authors.initials: A
authors.lastname: Schmitt
authors.forename: Peter
authors.initials: P
authors.lastname: Falkai
authors.forename: Sanaz
authors.initials: S
authors.lastname: Bahari-Javan
authors.forename: Susanne
authors.initials: S
authors.lastname: Burkhardt
authors.forename: Farahnaz
authors.initials: F
authors.lastname: Sananbenesi
authors.forename: Andre
authors.initials: A
authors.lastname: Fischer
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism; D000818:Animals; D005260:Female; D006624:Hippocampus / Q000378:metabolism*; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D035683:MicroRNAs / Q000378:metabolism*; D059467:Transcriptome
chemical_list: C522425:MIRN34 microRNA, human; C551848:MIRN34a microRNA, mouse; D035683:MicroRNAs