title: Electrical amygdala kindling.
abstract: This unit describes a method of electrical amygdala kindling in the rat. This procedure requires mastery of stereotaxic electrode implantation which is not covered in the current unit. Also, the investigator must have a sound knowledge of electronics and computing. The text gives instructions on how to render rats epileptic, how to determine the effects of compounds in kindled rats, and how to analyze the data. Results with three reference substances are illustrated. These substances are used in the clinic and give robust results in kindling.
authors.affiliation: Porsolt and Partners Pharmacology, Boulogne Billancourts, France.
authors.forename: N
authors.initials: N
authors.lastname: Dürmüller
authors.forename: R D
authors.initials: RD
authors.lastname: Porsolt
mesh_terms: D000679:Amygdala / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D002220:Carbamazepine / Q000494:pharmacology; D003627:Data Interpretation, Statistical; D003975:Diazepam / Q000494:pharmacology; D004569:Electroencephalography / Q000187:drug effects; D007696:Kindling, Neurologic / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014635:Valproic Acid / Q000494:pharmacology
chemical_list: D002220:Carbamazepine; D014635:Valproic Acid; D003975:Diazepam