title: Efficacy of chitooligosaccharides for the management of diabetes in alloxan induced mice: a correlative study with antihyperlipidemic and antioxidative activity.
abstract: The present study evaluates the effects of chitooligosaccharides (COS) for the management of alloxan induced diabetes in mice. For the management of the carbohydrate metabolism in diabetes by the COS, the amount of glucose in blood along with quantification of glycogen in liver were measured and noted a significant recovery in respect to diabetic control group. As hyperlipidemia and oxidative stress are the disorders of diabetes so, we have also assessed the serum levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDLc), very low density lipoprotein cholesterol (VLDLc) and high density lipoprotein cholesterol (HDLc). For the recovery of oxidative stress the SOD MDA catalase in liver and GOT and GPT activities in serum were measured. The COS results a significant recovery in the levels of above mentioned biosensors of lipid profile when treated to experimentally induce diabetic mice. The effect of COS at the dose of 10mg/kg body weight was found to be a potent agent for diabetes and complication associated with this disease. The COS has no toxic effect in general which has been focused here by the monitoring of COS dose in normal healthy mice. The results of this study enlighted that the COS has antidiabetic, antihyperlipidemic and antioxidative activities.
authors.affiliation: Department of Biochemistry & Bioprocess Technology, Jacob School of Biotechnology & Bio-engineering, Sam Higginbottom Institute of Agriculture, Technology and Sciences, Allahabad, India.
authors.forename: Deepmala
authors.initials: D
authors.lastname: Katiyar
authors.forename: Bharati
authors.initials: B
authors.lastname: Singh
authors.forename: Alok Milton
authors.initials: AM
authors.lastname: Lall
authors.forename: Chandana
authors.initials: C
authors.lastname: Haldar
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002374:Catalase / Q000378:metabolism; D002686:Chitin / Q000737:chemistry; D048271:Chitosan / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D002784:Cholesterol / Q000032:analysis / Q000097:blood; D003404:Creatinine / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D006003:Glycogen / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D008074:Lipoproteins / Q000737:chemistry; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009844:Oligosaccharides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D010206:Papain / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014280:Triglycerides / Q000097:blood; D014508:Urea / Q000097:blood
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D000960:Hypolipidemic Agents; D008074:Lipoproteins; D009844:Oligosaccharides; D017392:Thiobarbituric Acid Reactive Substances; D014280:Triglycerides; D002686:Chitin; D014508:Urea; D006003:Glycogen; D048271:Chitosan; D002784:Cholesterol; D003404:Creatinine; D002374:Catalase; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D010206:Papain