title: Urinary tract infections in polycystic kidney disease.
abstract: OBJECTIVE
  The aim of this study was to evaluate the bacteriological findings and the frequency of urinary tract infections in autosomal dominant polycystic kidney disease and their impact on renal function.
  
  
  METHODS
  One hundred eighty patients with autosomal dominant polycystic kidney disease were studied from 2003 to 2008. Subjects were considered as having urinary tract infections if they had had one or more episodes of urinary infection. The antibiotic therapy for the treatment has been adapted according to the bacteriological findings.
  
  
  RESULTS
  Urinary tract infections were observed in 60% of our patients (108 patients), and were more frequent in women than in men. The infections were typically caused by gram negative enteric organisms. Blood culture was positive in 10%, while urine culture was negative in 40%. The episodes of isolated cyst infections (negative urine culture and absence of white blood cell casts in urinary sediment) were more frequent than those of acute or chronic pyelonephritis (urinary sediment was positive for white blood cell casts).
  
  
  CONCLUSIONS
  We conclude that urinary tract infections are frequent in our patients with autosomal dominant polycystic kidney disease. Distinguishing between cyst infection and acute or chronic pyelonephritis is often a challenge, and the diagnosis relies mainly on clinical and bacteriological findings.
authors.affiliation: Laboratory of Bacteriology, University Hospital Center "Mother Teresa", Tirana, Albania. alma_idrizi@yahoo.com
authors.forename: Alma
authors.initials: A
authors.lastname: Idrizi
authors.forename: Myftar
authors.initials: M
authors.lastname: Barbullushi
authors.forename: Alketa
authors.initials: A
authors.lastname: Koroshi
authors.forename: Marinela
authors.initials: M
authors.lastname: Dibra
authors.forename: Eriola
authors.initials: E
authors.lastname: Bolleku
authors.forename: Valbona
authors.initials: V
authors.lastname: Bajrami
authors.forename: Xhoana
authors.initials: X
authors.lastname: Xhaferri
authors.forename: Nestor
authors.initials: N
authors.lastname: Thereska
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications*; D014552:Urinary Tract Infections / Q000150:complications* / Q000188:drug therapy; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents