title: [The protective effects of Aduola Fuzhenglin on the heart injury induced by microwave exposure in rats].
abstract: OBJECTIVE
  To study the protective effects of AduoLa Fuzhenglin(ADL) on the heart injury induced by microwave exposure in rats.
  
  
  METHODS
  One hundred forty male Wistar rats were divided randomly into 5 groups: control, microwave radiation, 0.75 g x kg(-1) d(-1) ADL, 1.50 g x kg(-1) d(-1) ADL and 3.00 g x kg(-1) d(-1) ADL pretreatment groups. Rats in three ADL pretreatment groups were administrated by ADL per day for 2w then exposed to 30 mW/cm2 microwaves for 15 min. The left ventricle blood of rats was obtained at 7 d and 14 d after exposure to microwaves, and the blood Ca2+, AST and CK were detected with Coulter automatic biochemical analyzer, then the histological changes and ultrastructure of heart were observed under light and electron microscopes.
  
  
  RESULTS
  At 7 d and 14 d after exposure to microwaves, the blood Ca2+, AST and CK concentrations significantly increased (P<0.05 or P<0.01) as compared with controls; Heart muscle fibers showed wavilness, endotheliocyte karyopyknosis, anachromasis; The mitochondria swelling and cavitation, intercalary dies blurred in radiation groups. The changes in 0.75 g x kg(-1) d(-1) ADL pretreatment group were similar to the radiation group, but in 1.50 g x kg(-1)d(-1) and 3.00 g x kg(-1) d(-1) ADL pretreatment groups, above indexes of rats significantly reduced as compared with microwaves group (P<0.05); also the blood Ca2+, AST, CK contents were significantly lower than those in microwave group (P<0.05); The heart showed a tendency to improve.
  
  
  CONCLUSIONS
  Microwave radiation (30 mW/cm2) can cause the blood Ca2+, AST and CK turbulence, and heart injury in the histology and ultrastructure; ADL at the dosages of 1.50 g x kg(-1) d(-1) and 3.00 g x kg(-1) d(-1) has a protective effects on the heart injury induced by microwave in rats.
authors.affiliation: Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Rui-yun
authors.initials: RY
authors.lastname: Peng
authors.forename: Jun-hui
authors.initials: JH
authors.lastname: Ren
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Shui-ming
authors.initials: SM
authors.lastname: Wang
authors.forename: Ya-bing
authors.initials: YB
authors.lastname: Gao
authors.forename: Qi
authors.initials: Q
authors.lastname: Dong
authors.forename: Li
authors.initials: L
authors.lastname: Zhao
authors.forename: Shu-chen
authors.initials: SC
authors.lastname: Liu
mesh_terms: D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002118:Calcium / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects / Q000528:radiation effects*; D008297:Male; D008872:Microwaves / Q000009:adverse effects*; D008929:Mitochondria, Heart / Q000528:radiation effects / Q000648:ultrastructure; D009206:Myocardium / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004365:Drugs, Chinese Herbal; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase; D002118:Calcium