title: Reactive oxygen species driven angiogenesis by inorganic nanorods.
abstract: The exact mechanism of angiogenesis by europium hydroxide nanorods was unclear. In this study we have showed that formation of reactive oxygen species (H(2)O(2) and O(2)·-) is involved in redox signaling pathways during angiogenesis, important for cardiovascular and ischemic diseases. Here we used single-walled carbon nanotube sensor array to measure the single-molecule efflux of H(2)O(2) and a HPLC method for the determination of O(2)·- from endothelial cells in response to proangiogenic factors. Additionally, reactive oxygen species-mediated angiogenesis using inorganic nanorods was observed in transgenic (fli1a:EGFP) zebrafish embryos.
authors.affiliation: Department of Chemical Biology, Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500607, AP, India. CRPatra@iict.res.in
authors.forename: Chitta Ranjan
authors.initials: CR
authors.lastname: Patra
authors.forename: Jong-Ho
authors.initials: JH
authors.lastname: Kim
authors.forename: Kallal
authors.initials: K
authors.lastname: Pramanik
authors.forename: Livius V
authors.initials: LV
authors.lastname: d'Uscio
authors.forename: Sujata
authors.initials: S
authors.lastname: Patra
authors.forename: Krishnendu
authors.initials: K
authors.lastname: Pal
authors.forename: Ramani
authors.initials: R
authors.lastname: Ramchandran
authors.forename: Michael S
authors.initials: MS
authors.lastname: Strano
authors.forename: Debabrata
authors.initials: D
authors.lastname: Mukhopadhyay
mesh_terms: D002478:Cells, Cultured; D042783:Endothelial Cells / Q000187:drug effects* / Q000502:physiology*; D006801:Humans; D007287:Inorganic Chemicals / Q000494:pharmacology*; D053758:Nanoparticles / Q000008:administration & dosage*; D018919:Neovascularization, Physiologic / Q000187:drug effects* / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism*
chemical_list: D007287:Inorganic Chemicals; D017382:Reactive Oxygen Species