title: Multiple genes in the 15q13-q14 chromosomal region are associated with schizophrenia.
abstract: OBJECTIVE
  The chromosomal region, 15q13-q14, including the α7 nicotinic acetylcholine receptor gene, CHRNA7, is a replicated region for schizophrenia. This study fine-mapped genes at 15q13-q14 to determine whether the association is unique to CHRNA7.
  
  
  METHODS
  Family-based and case-control association studies were performed on Caucasian-non-Hispanic and African-American individuals from 120 families as well as 468 individual patients with schizophrenia and 144 well-characterized controls. Single-nucleotide polymorphism (SNP) markers were genotyped, and association analyses carried out for the outcomes of schizophrenia, smoking, and smoking in schizophrenia.
  
  
  RESULTS
  Three genes were associated with schizophrenia in both ethnic populations: TRPM1, KLF13, and RYR3. Two SNPs in CHRNA7 were associated with schizophrenia in African-Americans, and a second SNP in CHRNA7 was significant for an association with smoking and smoking in schizophrenia in Caucasians.
  
  
  CONCLUSIONS
  Results of these studies support association of the 15q13-q14 region with schizophrenia. The broad positive association suggests that more than one 15q gene may be contributing to the disorder, either in combination or through a regulatory mechanism.
authors.affiliation: Department of Psychiatry, University of Colorado Denver, Colorado 80045, USA.
authors.forename: Sarah H
authors.initials: SH
authors.lastname: Stephens
authors.forename: Alexis
authors.initials: A
authors.lastname: Franks
authors.forename: Ralph
authors.initials: R
authors.lastname: Berger
authors.forename: Milda
authors.initials: M
authors.lastname: Palionyte
authors.forename: Tasha E
authors.initials: TE
authors.lastname: Fingerlin
authors.forename: Brandie
authors.initials: B
authors.lastname: Wagner
authors.forename: Judith
authors.initials: J
authors.lastname: Logel
authors.forename: Ann
authors.initials: A
authors.lastname: Olincy
authors.forename: Randal G
authors.initials: RG
authors.lastname: Ross
authors.forename: Robert
authors.initials: R
authors.lastname: Freedman
authors.forename: Sherry
authors.initials: S
authors.lastname: Leonard
mesh_terms: D001741:Black or African American / Q000235:genetics; D016022:Case-Control Studies; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics*; D005190:Family; D056726:Genetic Association Studies; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D060005:Genotyping Techniques; D006630:Hispanic or Latino / Q000235:genetics; D006801:Humans; D018895:Microsatellite Repeats / Q000235:genetics; D016017:Odds Ratio; D020161:Physical Chromosome Mapping; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012559:Schizophrenia / Q000235:genetics*; D012907:Smoking / Q000235:genetics; D044465:White People / Q000235:genetics
chemical_list: D005819:Genetic Markers