title: Tau protein: a possible prognostic factor in optic neuritis and multiple sclerosis.
abstract: BACKGROUND
  Tau protein has been proposed as biomarker of axonal damage leading to irreversible neurological impairment in MS. CSF concentrations may be useful when determining risk of progression from ON to MS.
  
  
  OBJECTIVE
  To investigate the association between tau protein concentration and 14-3-3 protein in the cerebrospinal fluid (CSF) of patients with monosymptomatic optic neuritis (ON) versus patients with monosymptomatic onset who progressed to multiple sclerosis (MS). To evaluate results against data found in a complete literature review.
  
  
  METHODS
  A total of 66 patients with MS and/or ON from the Department of Neurology of Glostrup Hospital, University of Copenhagen, Denmark, were included. CSF samples were analysed for tau protein and 14-3-3 protein, and clinical and paraclinical information was obtained from medical records.
  
  
  RESULTS
  The study shows a significantly increased concentration of tau protein in CSF from patients with relapsing-remitting MS and patients monosymptomatic at onset who progressed to MS, but interestingly no increased tau protein concentration in monosymptomatic ON. The concentration of tau protein was significantly correlated to Expanded Disability Status Scale score. No 14-3-3 protein was detected in any CSF sample.
  
  
  CONCLUSIONS
  The results of this study invite further exploration of the possible role of tau protein as a prognostic factor to predict progression from ON to MS in future studies.
authors.affiliation: Department of Neurology, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark. jefr@glo.regionh.dk
authors.forename: J
authors.initials: J
authors.lastname: Frederiksen
authors.forename: K
authors.initials: K
authors.lastname: Kristensen
authors.forename: J M C
authors.initials: JM
authors.lastname: Bahl
authors.forename: M
authors.initials: M
authors.lastname: Christiansen
mesh_terms: D048948:14-3-3 Proteins / Q000134:cerebrospinal fluid; D000328:Adult; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001921:Brain / Q000378:metabolism*; D003718:Denmark; D004185:Disability Evaluation; D018450:Disease Progression; D005260:Female; D006785:Hospitals, University; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D009902:Optic Neuritis / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D011379:Prognosis; D012720:Severity of Illness Index; D013997:Time Factors; D015854:Up-Regulation; D055815:Young Adult; D016875:tau Proteins / Q000134:cerebrospinal fluid*
chemical_list: D048948:14-3-3 Proteins; D015415:Biomarkers; C054369:MAPT protein, human; D016875:tau Proteins