title: Vascular signaling abnormalities in Alzheimer disease.
abstract: Our laboratory has documented that brain microvessels derived from patients with Alzheimer disease (AD) express or release a myriad of factors that have been implicated in vascular activation and angiogenesis. In addition, we have documented that signaling cascades associated with vascular activation and angiogenesis are upregulated in AD-derived brain microvessels. These results are consistent with emerging data suggesting that factors and processes characteristic of vascular activation and angiogenesis are found in the AD brain. Despite increases in proangiogenic factors and signals in the AD brain, however, evidence for increased vascularity in AD is lacking. Cerebral hypoperfusion/hypoxia, a potent stimulus for vascular activation and angiogenesis, triggers hypometabolic, cognitive, and degenerative changes in the brain. In our working model, hypoxia stimulates the angiogenic process; yet, there is no new vessel growth. Therefore, there are no feedback signals to shut off vascular activation, and endothelial cells become irreversibly activated. This activation results in release of a large number of proteases, inflammatory proteins, and other gene products with biologic activity that can injure or kill neurons. Pathologic activation of brain vasculature may contribute noxious mediators that lead to neuronal injury and disease processes in AD brains. This concept is supported by preliminary experiments in our laboratory, which show that pharmacologic blockade of vascular activation improves cognitive function in an animal model of AD. Thus, "vascular activation" could be a novel, unexplored therapeutic target in AD.
authors.affiliation: Garrison Institute on Aging and Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA. paula.grammas@ttuhsc.edu
authors.forename: Paula
authors.initials: P
authors.lastname: Grammas
authors.forename: Alma
authors.initials: A
authors.lastname: Sanchez
authors.forename: Debjani
authors.initials: D
authors.lastname: Tripathy
authors.forename: Ester
authors.initials: E
authors.lastname: Luo
authors.forename: Joseph
authors.initials: J
authors.lastname: Martinez
mesh_terms: D000544:Alzheimer Disease / Q000453:epidemiology / Q000473:pathology*; D002318:Cardiovascular Diseases / Q000150:complications / Q000473:pathology*; D004730:Endothelium, Vascular; D006801:Humans; D000860:Hypoxia; D007249:Inflammation / Q000473:pathology; D009389:Neovascularization, Pathologic; D012307:Risk Factors; D015398:Signal Transduction