title: [Migration of 51Cr-labeled neutrophils to rat lungs after administration of glucoocorticoid kenalog].
abstract: Cells from the rat bronchoalveolar lavage fluid comprising over 70% of neutrophils were labeled with 51Cr and administered intraperitoneally or intravenously to control animals and to rats which were injected subcutaneously with 2 mg of ketalog 5 days before the onset of experiment. Blood samples, lung, hepatic, splenic, renal, small intestinal, and muscular biposies were taken 1 hour after cell infusion. The intraperitoneal administration of 51Cr-labeled neutrophils did not significantly increase the radioactivity count rate in any organ examined. The rise was most notable in the lungs after v/v infusion of labeled neutrophils. Rats given kenalog showed a low level of radioactivity in the lung tissue compared with controls probably because the glucocorticoid caused a specific change in the mechanism of uptake of labeled neutrophils.
authors.forename: L N
authors.initials: LN
authors.lastname: Shishkina
authors.forename: E M
authors.initials: EM
authors.lastname: Malkova
mesh_terms: D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002465:Cell Movement / Q000187:drug effects*; D058948:Cell Tracking / Q000379:methods*; D002860:Chromium Radioisotopes; D004333:Drug Administration Routes; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects; D008168:Lung / Q000166:cytology* / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D002860:Chromium Radioisotopes; D005938:Glucocorticoids; D014222:Triamcinolone Acetonide