title: Human papillomavirus type distribution among heterosexual couples.
abstract: OBJECTIVE
  To gain a better understanding of human papillomavirus (HPV) transmission dynamics between sexual partners, HPV-type-specific concordance was investigated.
  
  
  METHODS
  Twenty-nine couples were enrolled in this cross-sectional study. Mean age was 30.5 years (range = 19.1-42.6 y) for men and 28.2 years (range = 19.4-44.5 y) for women. Samples were collected at the glans penis, penile shaft, and scrotum in men and at the endo/ectocervix and labia/vulva, and perineum in women. Samples were analyzed for the presence of HPV DNA first by polymerase chain reaction and then genotyped using the reverse-line blot method.
  
  
  RESULTS
  Human papillomavirus prevalence for any HPV type was 75.9% among men and 86.2% among women. Eleven men and 10 women were infected with multiple HPV types. At least partial type-specific concordance was observed in 66% of the couples. Forty-one percent of the couples had perfect concordance. In 11 couples (37.9%), complete discordance was observed.
  
  
  CONCLUSIONS
  These results provide valuable information about HPV-type-specific concordance and demonstrate the complexity of transmission dynamics in heterosexual couples.
authors.affiliation: Arizona Cancer Center, Tucson, AZ, USA. abalos@email.arizona.edu
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Abalos
authors.forename: Robin B
authors.initials: RB
authors.lastname: Harris
authors.forename: Alan G
authors.initials: AG
authors.lastname: Nyitray
authors.forename: Amy
authors.initials: A
authors.lastname: Mitchell
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Thompson
authors.forename: Anna R
authors.initials: AR
authors.lastname: Giuliano
authors.forename: Francisco
authors.initials: F
authors.lastname: Garcia
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D004279:DNA, Viral / Q000032:analysis / Q000302:isolation & purification; D005260:Female; D005836:Genitalia, Female / Q000821:virology; D005837:Genitalia, Male / Q000821:virology; D005838:Genotype; D020010:Heterosexuality / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000635:transmission* / Q000821:virology; D016133:Polymerase Chain Reaction / Q000379:methods; D015995:Prevalence; D012747:Sexual Partners; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D004279:DNA, Viral