title: Genomics reaches the clinic: from basic discoveries to clinical impact.
abstract: Today, more than ever, basic science research provides significant opportunities to advance our understanding about the genetic basis of human disease. Close interactions among laboratory, computational, and clinical research communities will be crucial to ensure that genomic discoveries advance medical science and, ultimately, improve human health.
authors.affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Teri A
authors.initials: TA
authors.lastname: Manolio
authors.forename: Eric D
authors.initials: ED
authors.lastname: Green
mesh_terms: D015720:5'-Nucleotidase / Q000378:metabolism; D002114:Calcinosis; D004194:Disease / Q000235:genetics*; D005263:Femoral Artery / Q000473:pathology; D058851:GPI-Linked Proteins / Q000378:metabolism; D055106:Genome-Wide Association Study; D023281:Genomics; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007083:Iliac Artery / Q000473:pathology; D015212:Inflammatory Bowel Diseases / Q000235:genetics / Q000628:therapy; D008297:Male; D009154:Mutation; D058729:Peripheral Arterial Disease / Q000235:genetics / Q000628:therapy; D010597:Pharmacogenetics; D035583:Rare Diseases / Q000175:diagnosis / Q000235:genetics; D051636:X-Linked Inhibitor of Apoptosis Protein / Q000235:genetics / Q000378:metabolism
chemical_list: D058851:GPI-Linked Proteins; D051636:X-Linked Inhibitor of Apoptosis Protein; C496866:XIAP protein, human; D015720:5'-Nucleotidase; C548241:NT5E protein, human