title: Role of Siglecs on the leucocytes during the process of the joint's inflammation in rheumatoid arthritis.
abstract: Rheumatoid arthritis (RA) is considered as an autoimmune disease that intermittently causes the chronic and acute inflammation of the patient's small joints which can destroy the tissues around the joints resulting in the limitation of the joint's function. In the synovium and synovia of the joints, the infiltration and/or phagocytosis of the different kinds of leucocytes were demonstrated according to the phases of the acute and chronic inflammation. Also, Siglecs (sialic acid binding Ig-like lectins) were reported on the leucocytes which can induce the active and inhibitory immune response by the specific binding with sialic acid on the conjugates including the sialylation of the immunoglobulin which has been reported there was striking increasing in the synovium and synovia of the small joints, also in the sera on RA cases. This hypothesis proposed Siglecs on the leucocytes which infiltrate into the joint's cavity and the increasing sialic acid conjugates might play a role during the acute and chronic inflammation on RA disease. It might be helpful to explain the mechanism of the different inflammation in different circumstances in the RA.
authors.affiliation: Department of Orthopedics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Sichuan, China. yangmed@126.com
authors.forename: Xiao
authors.initials: X
authors.lastname: Yang
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
mesh_terms: D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000503:physiopathology*; D006801:Humans; D037102:Lectins / Q000276:immunology* / Q000378:metabolism; D007962:Leukocytes / Q000276:immunology* / Q000378:metabolism; D018448:Models, Immunological; D019158:N-Acetylneuraminic Acid / Q000378:metabolism; D063265:Sialic Acid Binding Immunoglobulin-like Lectins
chemical_list: D037102:Lectins; D063265:Sialic Acid Binding Immunoglobulin-like Lectins; D019158:N-Acetylneuraminic Acid