title: [Galli-Galli disease. Clinical and histopathological investigation using a case series of 18 patients].
abstract: Galli-Galli disease, a rare genodermatosis belonging to the spectrum of reticulate pigment dermatoses, is classified as an acantholytic variant of Dowling-Degos disease on the basis of its characteristic clinical and histological findings. In the context of this case series, Galli-Galli disease is characterized in detail based on the clinical and histopathological evaluation of 18 patients. The disease pattern is discussed in view of the current literature. In addition, a classification into two clinical subtypes is made and a genotype/phenotype correlation with mutations in the keratin 5 (KRT5) gene is established.
authors.affiliation: Hautklinik, Universitätsklinikum Düsseldorf, Moorenstr. 5, 40225 Düsseldorf. Hanneken@med.uni-duesseldorf.de
authors.forename: S
authors.initials: S
authors.lastname: Hanneken
authors.forename: A
authors.initials: A
authors.lastname: Rütten
authors.forename: S
authors.initials: S
authors.lastname: Eigelshoven
authors.forename: M
authors.initials: M
authors.lastname: Braun-Falco
authors.forename: S M
authors.initials: SM
authors.lastname: Pasternack
authors.forename: T
authors.initials: T
authors.lastname: Ruzicka
authors.forename: M M
authors.initials: MM
authors.lastname: Nöthen
authors.forename: R C
authors.initials: RC
authors.lastname: Betz
authors.forename: R
authors.initials: R
authors.lastname: Kruse
mesh_terms: D000051:Acantholysis / Q000235:genetics* / Q000473:pathology*; D000328:Adult; D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D053555:Keratin-5 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012867:Skin / Q000473:pathology*
chemical_list: C503940:KRT5 protein, human; D053555:Keratin-5