title: Extrapulmonary comorbidities in chronic obstructive pulmonary disease: state of the art.
abstract: Extrapulmonary comorbidities are common and significant in chronic obstructive pulmonary disease (COPD), often contributing to symptoms, exacerbations, hospital admissions and mortality. Cardiovascular, musculoskeletal and psychological conditions are among the most prevalent and important of these. In particular, ischemic heart disease is a leading cause of death in the COPD population as a whole. Here, we provide a state-of-the-art summary of key comorbidities observed in COPD patients in terms of their prevalence, impact, pathophysiology and prognosis. In addition, we review clinical, diagnostic and management strategies that may differ in COPD patients from the rest of the population.
authors.affiliation: Academic Unit of Respiratory Medicine, Royal Free Campus, UCL Medical School, London, NW3 2PF, UK. anant.patel@ucl.ac.uk
authors.forename: Anant R C
authors.initials: AR
authors.lastname: Patel
authors.forename: John R
authors.initials: JR
authors.lastname: Hurst
mesh_terms: D002318:Cardiovascular Diseases / Q000453:epidemiology; D015897:Comorbidity; D006801:Humans; D001523:Mental Disorders / Q000453:epidemiology; D009140:Musculoskeletal Diseases / Q000453:epidemiology; D015995:Prevalence; D011379:Prognosis; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology* / Q000401:mortality / Q000503:physiopathology; D018570:Risk Assessment; D012307:Risk Factors