title: Reclassification of diabetes type in pediatric patients initially classified as type 2 diabetes mellitus: 15 years follow-up using routine data from the German/Austrian DPV database.
abstract: OBJECTIVE
  To examine change of diagnosis in patients from the German/Austrian multicenter DPV (Diabetes Patienten Verlaufsdokumentation) database initially classified as type 2 diabetes.
  
  
  METHODS
  Patients aged ≤20 years at onset, diagnosed between 1995 and 2010 were followed for at least 6 months. Chi-square/Wilcoxon tests were performed to compare patient groups according to diabetes type after reclassification.
  
  
  RESULTS
  From 580 study patients, 60 (10.3%) were reclassified, on average 2.4 years after initial diagnosis as follows: 23 (38.3%) as type 1 diabetes; 9 (15%) as maturity onset diabetes of the young (MODY); 20 (33.3%) as "other specific diabetes forms" and 8 (13.3%) as "remission" of type 2 diabetes. Patients reclassified to type 1 were significantly younger (13.5 ± 2.9 versus 14.0 ± 2.6; p=0.027) and more often β-cell antibody positive at disease onset (80.0% versus 31.2%; p=0.002), while patients reclassified as MODY had significantly lower BMI-SDS values than 520 patients with confirmed type 2 diabetes (2.5 ± 1.1 versus 0.9 ± 1.1; p<0.001). The latter were also considerably more obese than patients in "remission" and those reclassified to "other specific diabetes forms".
  
  
  CONCLUSIONS
  About 10% of patients in the DPV database, initially diagnosed as type 2 diabetes, were retrospectively reclassified.
authors.affiliation: Institute of Epidemiology and Medical Biometry, University of Ulm, 89081, Germany. wendy.awa@uni-ulm.de
authors.forename: W L
authors.initials: WL
authors.lastname: Awa
authors.forename: E
authors.initials: E
authors.lastname: Schober
authors.forename: S
authors.initials: S
authors.lastname: Wiegand
authors.forename: J
authors.initials: J
authors.lastname: Herwig
authors.forename: T
authors.initials: T
authors.lastname: Meissner
authors.forename: F
authors.initials: F
authors.lastname: Schmidt
authors.forename: E
authors.initials: E
authors.lastname: Molz
authors.forename: R W
authors.initials: RW
authors.lastname: Holl
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001317:Austria / Q000453:epidemiology; D016208:Databases, Factual; D003924:Diabetes Mellitus, Type 2 / Q000145:classification* / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012189:Retrospective Studies; D055815:Young Adult