title: Instantaneous room-temperature and highly enantioselective ArTi(O-i-Pr)3 additions to aldehydes.
abstract: Direct asymmetric additions of ArTi(O-i-Pr)(3) to aldehydes catalyzed by a titanium catalyst of (R)-H(8)-BINOL are reported. The reactions proceed instantaneously at room temperature, affording alcohols in ≥90% ee. Importantly, the ArTi(O-i-Pr)(3) reagent differentiates the ligand effectiveness in an order of H(8)-BINOL > BINOL > TADDOL > diol 3 > disulfonamide 2.
authors.affiliation: Department of Chemistry, National Chung Hsing University, Taichung 402, Taiwan, Republic of China.
authors.forename: Kuo-Hui
authors.initials: KH
authors.lastname: Wu
authors.forename: Shuangliu
authors.initials: S
authors.lastname: Zhou
authors.forename: Chien-An
authors.initials: CA
authors.lastname: Chen
authors.forename: Mao-Chi
authors.initials: MC
authors.lastname: Yang
authors.forename: Ruei-Tang
authors.initials: RT
authors.lastname: Chiang
authors.forename: Chi-Ren
authors.initials: CR
authors.lastname: Chen
authors.forename: Han-Mou
authors.initials: HM
authors.lastname: Gau
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D001128:Argon / Q000737:chemistry*; D013237:Stereoisomerism; D013696:Temperature; D014025:Titanium / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D001128:Argon; D014025:Titanium