title: Mass spectrometric immunoassay revisited.
abstract: The progressive understanding and improvement of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS), realized over the years through the considerable efforts of Dr. Marvin Vestal, have made possible numerous comparable efforts involving its application in the biological sciences. Here we revisit the concepts behind one such analytical approach, Mass Spectrometric Immunoassay, which is designed to selectively detect and quantify proteins present in biological milieu.
authors.affiliation: Molecular Biomarkers, The Biodesign Institute at Arizona State University, Tempe, AZ 85287, USA. randal.nelson@asu.edu
authors.forename: Randall W
authors.initials: RW
authors.lastname: Nelson
authors.forename: Chad R
authors.initials: CR
authors.lastname: Borges
mesh_terms: D007118:Immunoassay; D025202:Molecular Diagnostic Techniques; D011506:Proteins / Q000032:analysis / Q000737:chemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D011506:Proteins