title: Synthetic and biological applications of fluorous reagents as phase tags.
abstract: The search for new and better techniques for the purification of organic compounds has made the recent emergence of fluorous chemistry in the field of organic synthesis possible. Using fluorous reagents as phase tags allows for the access of different synthetic routes, and this has been translated into a time reduction and higher simplicity compared to standard, nonfluorous procedures. The synthesis in fluorous phase of target molecules can be pursued in a parallel or combinatorial manner in order to access chemical libraries with structural and/or stereochemical diversity. The preparation of radiolabeled molecules also benefits from the advantages of fluorous synthesis. Finally, biochemical tools such as microarrays or proteomic techniques are improved by means of fluorous-tagged compounds.
authors.affiliation: Departamento de Química Orgánica, Universidad de Valencia, Burjassot, Spain. santos.fustero@uv.es
authors.forename: Santos
authors.initials: S
authors.lastname: Fustero
authors.forename: José Luis
authors.initials: JL
authors.lastname: Aceña
authors.forename: Silvia
authors.initials: S
authors.lastname: Catalán
mesh_terms: D001695:Biology / Q000379:methods*; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D005466:Fluorocarbons / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry; D011854:Radiochemistry
chemical_list: D005466:Fluorocarbons; D007202:Indicators and Reagents