title: ABC transporters involved in drug resistance in human parasites.
abstract: The ABC (ATP-binding cassette) protein superfamily is a ubiquitous and functionally versatile family of proteins that is conserved from archaea to humans. In eukaryotes, most of these proteins are implicated in the transport of a variety of molecules across cellular membranes, whereas the remaining ones are involved in biological processes unrelated to transport. The biological functions of several ABC proteins have been described in clinically important parasites and nematode worms and include vesicular trafficking, phospholipid movement, translation and drug resistance. This chapter reviews our current understanding of the role of ABC proteins in drug resistance and treatment failure in apicomplexan, trypanosomatid and amitochondriate parasites of medical relevance as well as in helminths.
authors.affiliation: Centre de Recherche en Infectiologie, (Centre Hospitalier Universitaire de Québec) (Pavillon Centre Hospitalier de l'Université Laval), 2705 Boul. Laurier, Quebec City, QC, Canada.
authors.forename: Philippe
authors.initials: P
authors.lastname: Leprohon
authors.forename: Danielle
authors.initials: D
authors.lastname: Légaré
authors.forename: Marc
authors.initials: M
authors.lastname: Ouellette
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000502:physiology*; D000818:Animals; D004351:Drug Resistance; D006790:Host-Parasite Interactions; D006801:Humans; D011528:Protozoan Infections / Q000188:drug therapy / Q000469:parasitology*
chemical_list: D018528:ATP-Binding Cassette Transporters