title: Visual and IOP outcomes after PRK in pigment dispersion syndrome.
abstract: OBJECTIVE
  To report the results of photorefractive keratectomy (PRK) in patients with pigment dispersion syndrome.
  
  
  METHODS
  The pre- and postoperative records of patients with pigment dispersion syndrome who underwent PRK between January 2002 and March 2009 were reviewed. Data for analysis included gender, age, ablation depth, surgical complications, manifest refraction spherical equivalent, uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), intraocular pressure (IOP), central corneal thickness (CCT), cup-to-disc (c/d) ratio, and postoperative complications.
  
  
  RESULTS
  Thirty-seven eyes of 19 patients (17 men and 2 women) with a mean age of 37.5 ± 6.9 years were included for review. At final follow-up, mean 404.1±119.5 days postoperative, UDVA was 20/15 or better in 67.6%, 20/20 or better in 91.9%, and 20/25 or better in 100% of eyes; 94.6% of eyes were within 0.50 diopters (D) and 100% were within 1.00 D of emmetropia. Corrected distance visual acuity was unchanged from preoperative in 73% and improved by one line in 27% of eyes. No eye lost 1 or more lines of CDVA. When corrected for change in CCT and curvature, mean postoperative IOP was elevated from baseline (16.7 ± 3.8 mmHg) at 1 month (18.1 ± 4.9 mmHg, P =.044) but unchanged at any other time postoperatively. Two (11%) of 19 patients were steroid responders, requiring a single topical agent until completing the course of steroids. No significant change was noted in mean c/d ratio from baseline (0.35±0.12) to final postoperative (0.35 ± 0.13, P = .99).
  
  
  CONCLUSIONS
  Although PRK in patients with pigment dispersion syndrome resulted in excellent UDVA, retention of CDVA, and low incidence of adverse effects 1 to 2 years after surgery, long-term safety and efficacy outcomes of PRK in this cohort remain speculative
authors.affiliation: The Wilmer Eye Institute, Green Spring Station, Lutherville, MD 21093, USA. kbower5@jhmi.edu
authors.forename: Kraig S
authors.initials: KS
authors.lastname: Bower
authors.forename: Rose K
authors.initials: RK
authors.lastname: Sia
authors.forename: Denise S
authors.initials: DS
authors.lastname: Ryan
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Mines
authors.forename: Richard D
authors.initials: RD
authors.lastname: Stutzman
authors.forename: Chrystyna P
authors.initials: CP
authors.lastname: Kuzmowych
authors.forename: Jennifer B
authors.initials: JB
authors.lastname: Eaddy
authors.forename: Charles D
authors.initials: CD
authors.lastname: Coe
authors.forename: Keith J
authors.initials: KJ
authors.lastname: Wroblewski
mesh_terms: D000328:Adult; D003315:Cornea / Q000473:pathology; D017889:Exfoliation Syndrome / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D054018:Lasers, Excimer / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000503:physiopathology / Q000601:surgery*; D018903:Photorefractive Keratectomy; D011183:Postoperative Complications; D012029:Refraction, Ocular / Q000502:physiology; D014065:Tonometry, Ocular; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology*; D055815:Young Adult