title: Discovery of pyrazoles as novel FPR1 antagonists.
abstract: A series of pyrazole inhibitors of the human FPR1 receptor have been identified from high throughput screening. The compounds demonstrate potent inhibition in human neutrophils and attractive physicochemical and in vitro DMPK profiles to be of further interest.
authors.affiliation: AstraZeneca R&D Charnwood, Chemistry, Bakewell Road, Loughborough LE11 5RH, UK. andymorley@live.com
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Morley
authors.forename: Andrew
authors.initials: A
authors.lastname: Cook
authors.forename: Sarah
authors.initials: S
authors.lastname: King
authors.forename: Bryan
authors.initials: B
authors.lastname: Roberts
authors.forename: Sarah
authors.initials: S
authors.lastname: Lever
authors.forename: Richard
authors.initials: R
authors.lastname: Weaver
authors.forename: Cathy
authors.initials: C
authors.lastname: Macdonald
authors.forename: John
authors.initials: J
authors.lastname: Unitt
authors.forename: Malbinder
authors.initials: M
authors.lastname: Fagura
authors.forename: Tim
authors.initials: T
authors.lastname: Phillips
authors.forename: Richard
authors.initials: R
authors.lastname: Lewis
authors.forename: Mark
authors.initials: M
authors.lastname: Wenlock
mesh_terms: D055808:Drug Discovery; D006801:Humans; D009504:Neutrophils / Q000187:drug effects; D011720:Pyrazoles / Q000737:chemistry / Q000494:pharmacology*; D044042:Receptors, Formyl Peptide / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D011720:Pyrazoles; D044042:Receptors, Formyl Peptide