title: Overview of the use of transgenic animals in CNS drug discovery.
abstract: This overview highlights how transgenic mice, and related genetic manipulations, can contribute in important ways to the goal of developing novel treatments for neuropsychiatric disorders. A brief background of the field of drug discovery is covered and then new animal models of CNS disorders are discussed along with the topics of target validation, identification of novel targets, and functional genomics.
authors.affiliation: Yale University School of Medicine and Connecticut Mental Health Center, New Haven, Connecticut, USA.
authors.forename: E J
authors.initials: EJ
authors.lastname: Nestler
authors.forename: B
authors.initials: B
authors.lastname: Olivier
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D002491:Central Nervous System Agents / Q000737:chemistry / Q000627:therapeutic use*; D002493:Central Nervous System Diseases / Q000188:drug therapy / Q000235:genetics*; D004195:Disease Models, Animal; D055808:Drug Discovery / Q000379:methods* / Q000639:trends; D055785:Gene Knockdown Techniques / Q000379:methods; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic
chemical_list: D002491:Central Nervous System Agents