title: Response of glutathione system and carotenoids to sublethal copper in the postlarvae of Penaeus indicus.
abstract: The objective of this study is to determine the effect of sublethal copper on the glutathione system and carotenoids of Penaeus indicus postlarvae (PL) when subjected to short- and long-term exposure in the laboratory. The PL were exposed to 0.1641ppm (sublethal) copper for a period of 30 days with sampling intervals of 24, 48, 96h and 10, 20, 30 days. Variations in the activity of Glutathione reductase (GR), Glutathione peroxidase (GPx) and Glutathione-S-transferase (GSTase) were measured as biomarkers of toxicity. A significant (P<0.05) increase in the GR and GPx activity of the exposed PL till 20 days of exposure and thereafter a significant decrease indicates susceptibility of the PL to oxidative stress upon chronic exposure. Similarly, a significant decrease in GSTase activity during long-term exposures in the exposed PL reflects possible failure of the detoxification system. A possible role of carotenoids to combat oxidative stress against copper toxicity is also discussed.
authors.affiliation: Department of Zoology, Andhra University, Visakhapatnam, India. vaniprupa@yahoo.co.in
authors.forename: Rupa
authors.initials: R
authors.lastname: Vani Paila
authors.forename: Prabhakara
authors.initials: P
authors.lastname: Rao Yallapragada
authors.forename: Samuel David Raj
authors.initials: SD
authors.lastname: Thatipaka
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002338:Carotenoids / Q000378:metabolism*; D003300:Copper / Q000633:toxicity*; D004784:Environmental Monitoring; D005978:Glutathione / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology; D033561:Penaeidae / Q000187:drug effects* / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D015415:Biomarkers; D014874:Water Pollutants, Chemical; D002338:Carotenoids; D003300:Copper; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D005978:Glutathione