title: Novel rhein analogues as potential anticancer agents.
abstract: Two series of rhein analogues were synthesized with modification at the 3-position. Their cytotoxicities were evaluated using an MTT assay. Among all the compounds synthesized, one compound showed the best potency, with an IC(50) value of 2.7 μM against the HeLa cell line and 0.6 μM against the MOLT4 cell line.
authors.affiliation: Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, 100 Piedmont Ave., Atlanta, GA 30303-4098, USA.
authors.forename: Xiaochuan
authors.initials: X
authors.lastname: Yang
authors.forename: Guojing
authors.initials: G
authors.lastname: Sun
authors.forename: Chunhao
authors.initials: C
authors.lastname: Yang
authors.forename: Binghe
authors.initials: B
authors.lastname: Wang
mesh_terms: D000880:Anthraquinones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D009369:Neoplasms; D013329:Structure-Activity Relationship
chemical_list: C571077:1,8-dihydroxy-3-(2'-chloro-acetamido)anthraquinone; D000880:Anthraquinones; D000970:Antineoplastic Agents; C020491:rhein