title: [Prognostic value of the molecular markers cyclin D1 and P53 in patients with lung cancer].
abstract: The discovery of new genes with important regulatory functions on cellular level, allowed the investigation of many biological and molecular changes and defining their value as potential prognostic factors.
  
  
  METHODS
  The study included 122 patients with non-small cell lung cancer. We examined the expression of cyclin D1 and p53.
  
  
  RESULTS
  The 5-years survival rate was 26% for the group with strong nuclear expression of cyclin D1, and 80% for the group with moderate expression of the marker. We found 5-years survival rate of 100% for the group with poor expression of p53, and 24.55% for the group with strong expression.
  
  
  CONCLUSIONS
  The increased levels of cyclin D1 and p53 are negative prognostic factors for the patients with non-small cell lung cancer.
authors.forename: A
authors.initials: A
authors.lastname: Uchikov
authors.forename: B
authors.initials: B
authors.lastname: Hadjiev
authors.forename: I
authors.initials: I
authors.lastname: Dimitrov
authors.forename: G
authors.initials: G
authors.lastname: Prisadov
authors.forename: E
authors.initials: E
authors.lastname: Uchikova
authors.forename: A
authors.initials: A
authors.lastname: Batashki
authors.forename: P
authors.initials: P
authors.lastname: Ganchevska
mesh_terms: D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000401:mortality; D019938:Cyclin D1; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53
chemical_list: D016159:Tumor Suppressor Protein p53; D019938:Cyclin D1