title: Trace elements of normal, benign hypertrophic and cancerous tissues of the human prostate gland investigated by neutron activation analysis.
abstract: The Ag, Co, Cr, Fe, Hg, Rb, Sb, Sc, Se, and Zn contents in normal (n=37), benign hypertrophic (n=43), and cancerous tissues (n=60) of the human prostate gland were investigated by neutron activation analysis. Mean values (M±SΕΜ) for content (mg/kg, dry weight basis) of trace elements in the normal tissue were: Ag-0.048±0.009, Co-0.045±0.004, Cr-0.53±0.08, Fe-111±9, Hg-0.056±0.011, Rb-12.7±0.9, Sb-0.045±0.007, Sc-0.029±0.005, Se-0.70±0.04, and Zn-1000±110, respectively. It was observed that in benign hypertrophic tissues the contents of Co, Cr, Hg, Sb, and Se were higher than in normal tissues, with statistically significant differences. The contents of Co, Rb, Sc, and Zn were significantly lower and those of Ag, Cr, Fe, Hg, and Sb were significantly higher in cancerous tissues than in normal tissues.
authors.affiliation: Radionuclide Diagnostics Department, Medical Radiological Research Centre, Russian Academy of Medical Sciences, Koroleva Street- 4, Obninsk 249020, Kaluga Region, Russia. s-zaichick@northwestern.edu
authors.forename: Sofia
authors.initials: S
authors.lastname: Zaichick
authors.forename: Vladimir
authors.initials: V
authors.lastname: Zaichick
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009501:Neutron Activation Analysis / Q000379:methods*; D011470:Prostatic Hyperplasia / Q000175:diagnosis* / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014131:Trace Elements / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; D014131:Trace Elements