title: Preparation and evaluation of orally rapidly disintegrating tablets containing taste-masked particles using one-step dry-coated tablets technology.
abstract: In this study, in order to address the problems with manufacturing orally rapidly disintegrating tablets (ODT) containing functional (taste masking or controlled release) coated particles, such as the low compactability of coated particles and the rupture of coated membrane during compression, a novel ODT containing taste-masked coated particles (TMP) in the center of the tablets were prepared using one-step dry-coated tablets (OSDrC) technology. As a reference, physical-mixture tablets (PM) were prepared by a conventional tableting method, and the properties of the tablets and the effect of compression on the characteristics of TMP were evaluated. OSDrC was found to have higher tensile strength and far lower friability than PM, but the oral disintegration time of OSDrC is slightly longer than that of PM following high compression pressure. Consequently, OSDrC approaches the target tablet properties of ODT, whereas PM does not. The deformation of TMP in OSDrC due to compression is slight, and the release rate of acetaminophen (AAP) from OSDrC is the same as from TMP. However, TMP on the surface of PM are considerably deformed, and the release rate of AAP from PM is faster than from TMP. These findings suggest that OSDrC technology is a useful approach for preparing ODT containing functional coated particles. Furthermore, we demonstrate that the elastic recovery of tablets can affect differences in the properties of OSDrC, PM and placebo tablets (PC).
authors.affiliation: Faculty of Pharmacy, Meijo University, Nagoya, Japan. 103674501@ccalumni.meijo-u.ac.jp
authors.forename: Keita
authors.initials: K
authors.lastname: Kondo
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Niwa
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ozeki
authors.forename: Masaki
authors.initials: M
authors.lastname: Ando
authors.forename: Kazumi
authors.initials: K
authors.lastname: Danjo
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D019245:Compressive Strength; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems; D005079:Excipients / Q000737:chemistry; D006801:Humans; D008956:Models, Chemical; D016062:Porosity; D011208:Powders; D012995:Solubility; D013395:Sucrose / Q000737:chemistry; D013607:Tablets / Q000008:administration & dosage / Q000737:chemistry*; D013649:Taste; D013718:Tensile Strength
chemical_list: D018712:Analgesics, Non-Narcotic; D005079:Excipients; D011208:Powders; D013607:Tablets; D000082:Acetaminophen; D013395:Sucrose; D002482:Cellulose; C008079:hydroxypropylcellulose