title: Wegener's granulomatosis of the orbit: a review of clinical features and updates in diagnosis and treatment.
abstract: Wegener's Granulomatosis (WG) is an uncommon systemic vasculitic disease involving the respiratory system and kidneys. It is the most common antineutrophil cytoplasm antibody (ANCA)-associated vasculitis. Orbital involvement in WG is a rare but potentially devastating disorder leading to visual loss and deformity. Most clinical characteristics of this disease are non-specific, making clinical diagnosis nearly impossible. We reviewed the features of WG involving the orbit including radiologic, serologic, and histopathologic findings. Advances in treatment are likewise discussed.
authors.affiliation: Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
authors.forename: Yvette Marie
authors.initials: YM
authors.lastname: Santiago
authors.forename: Aaron
authors.initials: A
authors.lastname: Fay
mesh_terms: D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D009916:Orbital Diseases / Q000175:diagnosis* / Q000628:therapy*