title: Pristine C(60) fullerenes inhibit the rate of tumor growth and metastasis.
abstract: OBJECTIVE
  To estimate the impact of C(60) fullerene aqueous solution (C(60)FAS) on the rate of transplanted malignant tumor growth and metastasis.
  
  
  METHODS
  Lewis lung carcinoma was transplanted into С57Bl/6J male mice. Conventional methods for the evaluation of antitumor and antimetastatic effects have been used.
  
  
  RESULTS
  The C(60)FAS at low single therapeutic dose of 5 mg/kg inhibited the growth of transplanted malignant tumor (antitumor effect) and metastasis (antimetastatic effect): the maximum therapeutic effect was found to be of 76.5% for the tumor growth inhibition; the increase of animal life span by 22% was found; the metastasis inhibition index was estimated as 48%.
  
  
  CONCLUSIONS
  It was found that water-soluble pristine С(60) fullerenes efficiently inhibit the transplanted malignant tumor growth and metastasis.
authors.affiliation: Taras Shevchenko National University of Kyiv, Institute of Biology, Volodymyrska Str., 64, 01601 Kyiv, Ukraine. prylut@ukr.net
authors.forename: S V
authors.initials: SV
authors.lastname: Prylutska
authors.forename: A P
authors.initials: AP
authors.lastname: Burlaka
authors.forename: Yu I
authors.initials: YI
authors.lastname: Prylutskyy
authors.forename: U
authors.initials: U
authors.lastname: Ritter
authors.forename: P
authors.initials: P
authors.lastname: Scharff
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy* / Q000473:pathology* / Q000556:secondary; D049109:Cell Proliferation / Q000187:drug effects; D037741:Fullerenes / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis / Q000188:drug therapy; D009368:Neoplasm Transplantation
chemical_list: D000970:Antineoplastic Agents; D037741:Fullerenes; C530172:pristine (C60)