title: Ferumoxytol: a new era of iron deficiency anemia treatment for patients with chronic kidney disease.
abstract: Ferumoxytol is a new product approved for intravenous use by the US Food and Drug Administration (FDA) in the treatment of iron deficiency anemia in adults with chronic kidney disease. This approval was based on data from 3 open-label, randomized, controlled clinical trials. In all of these trials, ferumoxytol was well tolerated, and hemoglobin levels were significantly increased compared with those achieved by orally administered iron. Ferumoxytol, a superparamagnetic iron oxide coated with a carbohydrate shell, is also used as a magnetic resonance imaging (MRI) agent due to its magnetic properties. In addition, it has demonstrated a greater T1 relaxation time than MRI gadolinium-contrast agents. Currently, the Ferumoxytol Compared to Iron Sucrose Trial (FIRST) has started. This is a multicenter randomized trial of ferumoxytol compared with iron sucrose for the treatment of iron deficiency anemia in adult subjects with chronic kidney disease, where intravenous ferumoxytol is being compared with other intravenous agents to evaluate the safety of ferumoxytol and assess changes in hemoglobin level.
authors.affiliation: Department of Nephrology, Medical University of Lodz, Lodz, Poland.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Kowalczyk
authors.forename: Maciej
authors.initials: M
authors.lastname: Banach
authors.forename: Jacek
authors.initials: J
authors.lastname: Rysz
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000188:drug therapy* / Q000453:epidemiology* / Q000378:metabolism; D002908:Chronic Disease; D015897:Comorbidity; D005290:Ferric Compounds / Q000009:adverse effects / Q000627:therapeutic use; D000077605:Ferric Oxide, Saccharated; D052203:Ferrosoferric Oxide / Q000009:adverse effects / Q000627:therapeutic use*; D005937:Glucaric Acid; D006397:Hematinics / Q000009:adverse effects / Q000627:therapeutic use; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007674:Kidney Diseases / Q000453:epidemiology* / Q000378:metabolism
chemical_list: D005290:Ferric Compounds; D006397:Hematinics; D006454:Hemoglobins; D000077605:Ferric Oxide, Saccharated; D005937:Glucaric Acid; D052203:Ferrosoferric Oxide