title: Concise synthesis and antitumor activities of trisaccharide steroidal saponins.
abstract: The naturally derived trisaccharide steroidal saponin 1 and structurally modified derivatives 2 and 3 bearing the same sarsasapogenin aglycon were synthesized concisely via a direct transglycosylation strategy. The antitumor activities of the synthetic trisaccharide saponins 1-3 and their corresponding α-isomers 1a-3a were preliminarily evaluated against human gastric adenocarcinoma cell (MKN-45) and human epithelial cervical cancer cell (HeLa) by CCK-8 assay.
authors.affiliation: National Glycoengineering Research Center, Shandong University, Jinan 250100, PR China. guofenggu@sdu.edu.cn
authors.forename: Guofeng
authors.initials: G
authors.lastname: Gu
authors.forename: Min
authors.initials: M
authors.lastname: Fang
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Gu
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006031:Glycosylation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D012503:Saponins / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D012503:Saponins; C570003:sarsasapogenyl arabinopyranosyl-(1-4)-(arabinopyranosyl-(1-6))glucopyranoside; C570002:sarsasapogenyl glucopyranosyl-(1-4)-(arabinopyranosyl-(1-6))glucopyranoside; C570004:sarsasapogenyl glucopyranosyl-(1-4)-(glucopyranosyl-(1-6))glucopyranoside