title: A nonsynonymous functional variant of the ITGAM gene is not involved in biopsy-proven giant cell arteritis.
abstract: OBJECTIVE
  To investigate whether a functional integrin alpha M (ITGAM) variant is involved in susceptibility to and clinical manifestations of giant cell arteritis (GCA).
  
  
  METHODS
  A Spanish cohort of 437 white patients with biopsy-proven GCA and 1388 healthy controls were genotyped using the TaqMan allele discrimination technology.
  
  
  RESULTS
  No association was observed between ITGAM rs1143679 and GCA (p = 0.80, OR 0.97). Similarly, subphenotype analyses did not yield significant differences between the case subgroups and the control set or between GCA patients with or without the main specific features of GCA.
  
  
  CONCLUSIONS
  Our results suggest that the ITGAM rs1143679 variant does not play an important role in the pathophysiology of GCA.
authors.affiliation: Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain. dcarmona@ipb.csic.es
authors.forename: F David
authors.initials: FD
authors.lastname: Carmona
authors.forename: Aurora
authors.initials: A
authors.lastname: Serrano
authors.forename: Luis
authors.initials: L
authors.lastname: Rodríguez-Rodríguez
authors.forename: Santos
authors.initials: S
authors.lastname: Castañeda
authors.forename: José A
authors.initials: JA
authors.lastname: Miranda-Filloy
authors.forename: Inmaculada C
authors.initials: IC
authors.lastname: Morado
authors.forename: Javier
authors.initials: J
authors.lastname: Narváez
authors.forename: Roser
authors.initials: R
authors.lastname: Solans
authors.forename: Bernardo
authors.initials: B
authors.lastname: Sopeña
authors.forename: Begoña
authors.initials: B
authors.lastname: Marí-Alfonso
authors.forename: Ainhoa
authors.initials: A
authors.lastname: Unzurrunzaga
authors.forename: Norberto
authors.initials: N
authors.lastname: Ortego-Centeno
authors.forename: Ricardo
authors.initials: R
authors.lastname: Blanco
authors.forename: Eugenio
authors.initials: E
authors.lastname: de Miguel
authors.forename: Ana
authors.initials: A
authors.lastname: Hidalgo-Conde
authors.forename: Javier
authors.initials: J
authors.lastname: Martín
authors.forename: Miguel A
authors.initials: MA
authors.lastname: González-Gay
mesh_terms: D000368:Aged; D001706:Biopsy; D039481:CD11b Antigen / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D013700:Giant Cell Arteritis / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D013030:Spain
chemical_list: D039481:CD11b Antigen; C509295:ITGAM protein, human