title: AIMing at metabolic syndrome. -Towards the development of novel therapies for metabolic diseases via apoptosis inhibitor of macrophage (AIM).-.
abstract: Metabolic syndrome (MetS) is a cascade of metabolic diseases, starting with obesity and progressing to atherosclerosis, and is often fatal because of serious cardiovascular problems such as heart/brain infarction and hemorrhage. Accumulating evidence has revealed a critical involvement of inflammatory responses triggered by lesional macrophages in the pathogenesis of MetS. Importantly, we found that macrophages are associated with disease progression, not only in the induction of inflammation but also in the production of apoptosis inhibitor of macrophages (AIM), which we initially identified as a soluble factor expressed by macrophages. In atherosclerotic plaques, AIM is highly expressed by foam macrophages and inhibits apoptosis of these cells, which results in the accumulation of macrophages, causing inflammatory responses within the lesion, and ultimately disease progression. In adipose tissue, macrophage-derived AIM is incorporated into adipocytes through CD36-mediated endocytosis, thereby reducing the activity of cytosolic fatty acid synthase. This unique response stimulates lipolysis, resulting in a decrease in adipocyte size, which is physiologically relevant to the prevention of obesity. The lipolytic response also stimulates inflammation of adipocytes in association with the induction of metabolic disorders subsequent to obesity. Thus, AIM is involved in the progression of MetS in both an advancing and inhibitory fashion. Regulation of AIM could therefore be therapeutically applicable for MetS.
authors.affiliation: Laboratory of Molecular Biomedicine for Pathogenesis, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo, Japan. tm@m.u-tokyo.ac.jp
authors.forename: Toru
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Jun
authors.initials: J
authors.lastname: Kurokawa
authors.forename: Satoko
authors.initials: S
authors.lastname: Arai
mesh_terms: D017667:Adipocytes / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism*; D018955:CD36 Antigens / Q000378:metabolism; D004705:Endocytosis; D064429:Fatty Acid Synthases / Q000378:metabolism; D005487:Foam Cells / Q000378:metabolism* / Q000473:pathology; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D008066:Lipolysis; D024821:Metabolic Syndrome / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D009765:Obesity / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D058226:Plaque, Atherosclerotic / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D051116:Receptors, Scavenger; D051122:Scavenger Receptors, Class B / Q000378:metabolism*
chemical_list: D051017:Apoptosis Regulatory Proteins; D018955:CD36 Antigens; C492821:CD5L protein, human; D051116:Receptors, Scavenger; D051122:Scavenger Receptors, Class B; D064429:Fatty Acid Synthases