title: [Enhancing effect of volatile oils of rhizoma zingiberis, flos magnoliae and fructus litseae on permeation of rotundine in vitro].
abstract: OBJECTIVE
  To investigate the enhancing effect of volatile oils of Rhizoma Zingiberis (RZ), Flos Magnoliae (FM), Fructus Litseae (FL), Azone and pairwise combinations on the permeation of Rotundine in vitro.
  
  
  METHODS
  To screen out the volatile oils with the best percutaneous enhancing effect on Rotundine, a test of penetration through rats skin was conducted by using an improved Franz diffusion cell. The accumulative penetration amount of Rotundine was determined by UV and HPLC.
  
  
  RESULTS
  All of the 3 volatile oils had enhancing effect on Rotundine permeation. The average accumulative doses of Rotundine for 8 hours (Q8, mg/cm2) of 5% volatile oil of FL, 5% volatile oil of, RZ, 2.5% FL + 2.5% Azone were 6.0758, 6.1148, 6.5487, the enhancement ratios of 4 hours were 1.01, 1.00, 1.13 respectively.
  
  
  CONCLUSIONS
  2.5% FL + 2.5% Azone had the best effect of percutaneous enhancing on Rotundine.
authors.affiliation: College of Chinese Traditional Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650200, China. cuilili_04@163.com
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Cui
authors.forename: Yun-Shu
authors.initials: YS
authors.lastname: Ma
authors.forename: Hui-Xun
authors.initials: HX
authors.lastname: Han
mesh_terms: D000279:Administration, Cutaneous; D000700:Analgesics / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D001600:Berberine Alkaloids / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D051379:Mice; D009822:Oils, Volatile / Q000302:isolation & purification / Q000494:pharmacology*; D010539:Permeability / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D012869:Skin Absorption / Q000187:drug effects*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000700:Analgesics; D001600:Berberine Alkaloids; D004365:Drugs, Chinese Herbal; D009822:Oils, Volatile; C014215:tetrahydropalmatine