title: [Risk factors for fragility fractures in a cohort of Spanish women].
abstract: BACKGROUND
  Fragility fractures are an important public health issue. The aim of this study was to analyze the association of the main osteoporotic risk factors related to fragility fracture in a cohort of women with an indication of bone densitometry (BD).
  
  
  METHODS
  A retrospective cohort was followed-up until a fragile fracture occurred, in a population of women aged 40 to 90 years with a first visit for BD between January 1992 and February 2008. We calculated the incidence rate of fracture per 1000 women-years of follow-up, and the hazard ratio (HR) of fragile fracture using a Cox regression model.
  
  
  RESULTS
  A total of 49,735 women were studied. The average age of participants was 57.8 years (SD: 8.5). Of these, 3631 women (7.1%) reported a new fragility fracture in post-baseline visits. Risk factors with higher adjusted HR were age ≥ 75 years compared with age < 55 years (HR: 3.8; 95% CI: 3.3-4.4) and having a BC result evaluated as osteoporosis compared to normal (HR: 2.0; 95% CI: 1.8-2.2). A personal history of humerus, hip or vertebral fractures had an adjusted HR of 1.2 (95% CI: 1.1-1.3).
  
  
  CONCLUSIONS
  The main risk factors for fragility fracture were advanced age, BD result and a personal history of fracture, although 74% of fractures were detected with a bone mineral density classified as normal or osteopenia. Other relevant factors were rheumatoid arthritis or having received prolonged corticosteroid therapy.
authors.affiliation: Agència d'Informació, Avaluació i Qualitat en Salut (AIAQS), Barcelona, España. ctebe@aatrm.catsalut.cat
authors.forename: Cristian
authors.initials: C
authors.lastname: Tebé
authors.forename: Luis Miguel
authors.initials: LM
authors.lastname: del Río
authors.forename: Lidia
authors.initials: L
authors.lastname: Casas
authors.forename: Maria-Dolors
authors.initials: MD
authors.lastname: Estrada
authors.forename: Anna
authors.initials: A
authors.lastname: Kotzeva
authors.forename: Silvana
authors.initials: S
authors.lastname: Di Gregorio
authors.forename: Mireia
authors.initials: M
authors.lastname: Espallargues
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000150:complications; D001835:Body Weight; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000150:complications; D002136:Calcium, Dietary; D005260:Female; D005500:Follow-Up Studies; D005598:Fractures, Spontaneous / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D010024:Osteoporosis / Q000139:chemically induced / Q000150:complications*; D015663:Osteoporosis, Postmenopausal / Q000150:complications; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D013030:Spain
chemical_list: D000305:Adrenal Cortex Hormones; D002136:Calcium, Dietary