title: [Uterine artery score in patients with systemic lupus erythematous as a predictor of intrauterine growth restriction].
abstract: BACKGROUND
  Because of its high prevalence in the female population and its high incidence in reproductive age, Systemic Lupus Erythematosus can complicate pregnancy causing miscarriage, fetal death, preeclampsia, fetal growth restriction (up to 25%) and preterm birth. Doppler ultrasonography measures the flow in the uterine arteries, which is reduced in patients with preeclampsia and FGR, and thus is an ideal method for identifying pregnant women with a high risk of developing an adverse perinatal outcome.
  
  
  OBJECTIVE
  Identify if Doppler ultrasound predicts FGR in patients with systemic lupus erythematosus.
  
  
  METHODS
  In this observational, transversal, prospective study carried out from June 1st, 2010 to November 30th, 2010, in patients who had already been diagnosed with SLE, a complete clinical history was registered, blood samples taken and Doppler of uterine arteries between 18 and 23 gestation weeks taken (measuring the pulsatility index)
  
  
  RESULTS
  Of the 17 women in the study, 6 patients had a PI equal or greater than 1.45 (35.29%), of whom in 5 cases (29.41%), the product had FGR. Therefore the sensitivity of this test is 100%, with a specificity of 91%, a predictive positive value of 83% and a predictive negative value of 100%. With a p of 0.0010, which is considered extremely significant, and a confidence interval of 95%.
  
  
  CONCLUSIONS
  There exists a high association between an abnormal PI and the development of FGR. Abnormal Doppler ultrasound of uterine arteries is useful for predicting FGR in pregnant women with SLE.
authors.affiliation: Jefe de División de Ginecologia y Obstetricia.
authors.forename: José Angel
authors.initials: JA
authors.lastname: López-Farfán
authors.forename: Dolores G
authors.initials: DG
authors.lastname: Martínez-Marín
authors.forename: Tatiana
authors.initials: T
authors.lastname: Van Der Heyden-Pardo
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D008180:Lupus Erythematosus, Systemic / Q000503:physiopathology*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D011446:Prospective Studies; D011673:Pulsatile Flow; D012680:Sensitivity and Specificity; D018608:Ultrasonography, Doppler; D055988:Uterine Artery / Q000000981:diagnostic imaging* / Q000503:physiopathology; D055815:Young Adult