title: Study on the role of environmental parameters and HIF-1A gene polymorphism in coronary collateral formation among patients with ischemic heart disease.
abstract: OBJECTIVE
  To evaluate the association between collateral formation and some environmental factors along with a polymorphism in HIF-1A gene in selected Iranian patients with CAD.
  
  
  METHODS
  Patients with ≥ 70% narrowing in at least one coronary vessel according to coronary angiography were enrolled. The patients' demographic, clinical and biochemical data were collected. The presence of C1772T polymorphisms within HIF-1A was analyzed using the polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP).
  
  
  RESULTS
  There is no significant difference between the patients with and without collaterals according to the frequency of T allele or HIF-1A variants. The higher severity of coronary vessel obstruction was positive predictor of collateral formation (OR=1.026, 95%, CI: 1.02-0.04, p<0.001), whereas aging and cigarette smoking were negative predictors (OR=0.95, 95% CI: 0.91-0.99, p<0.05; OR=0.30, 95% CI: 0.11-0.79, p <0.05; respectively).
  
  
  CONCLUSIONS
  The findings indicate not any significant association between collateral formation and polymorphic variants of HIF-1A and P582S substitution does not appear to influence the collateral formation in patients with myocardial ischemia.
authors.affiliation: Interventional Cardiology Department, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Alidoosti
authors.forename: Mahboobeh
authors.initials: M
authors.lastname: Ghaedi
authors.forename: Abbas
authors.initials: A
authors.lastname: Soleimani
authors.forename: Salar
authors.initials: S
authors.lastname: Bakhtiyari
authors.forename: Mehrnaz
authors.initials: M
authors.lastname: Rezvanfard
authors.forename: Shekufeh
authors.initials: S
authors.lastname: Golkhu
authors.forename: Narges
authors.initials: N
authors.lastname: Mohammadtaghvaei
mesh_terms: D000368:Aged; D019943:Amino Acid Substitution; D003097:Collateral Circulation / Q000235:genetics*; D017023:Coronary Angiography; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging / Q000209:etiology* / Q000235:genetics; D018919:Neovascularization, Physiologic / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit