title: Barrett's esophagus: prevalence and incidence of adenocarcinomas.
abstract: The following on prevalence and incidence of adenocarcinomas in Barrett's esphophagus (BE) includes commentaries on the mechanisms of a potential protective effect of proton pump inhibitors (PPIs) on progression of BE to high-grade dysplasia; evaluation of the role of PPIs in decreasing the risk of degeneration; the geographical variations of incidence of BE; the role of the nonmorphologic biomarkers; the relationship between length of BE and development of cancer; the confounding factors in incidence rates of BE; the role of the increase of cell differentiation and apoptosis induced by PPIs in the diminution of cancer risk; the frequency of occult neoplastic foci and unsuspected invasive cancer in surgical specimens; the influence on the indications of endoscopic therapy; the overestimation of regression in surgical series; attempts to evaluate the reasons for variations of cancer incidence in the literature; and progress in screening and surveillance for BE.
authors.affiliation: Gastroenterology Division, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
authors.forename: Helen M
authors.initials: HM
authors.lastname: Shields
authors.forename: Gerardo
authors.initials: G
authors.lastname: Nardone
authors.forename: Jingjing
authors.initials: J
authors.lastname: Zhao
authors.forename: Wen
authors.initials: W
authors.lastname: Wang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Xing
authors.forename: Dianchun
authors.initials: D
authors.lastname: Fang
authors.forename: Brian C
authors.initials: BC
authors.lastname: Jacobson
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Romero
authors.forename: Katerina
authors.initials: K
authors.lastname: Dvorak
authors.forename: Aaron
authors.initials: A
authors.lastname: Goldman
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Pellegrini
authors.forename: Elizabeth L
authors.initials: EL
authors.lastname: Wiley
authors.forename: David A
authors.initials: DA
authors.lastname: Peura
authors.forename: Roger P
authors.initials: RP
authors.lastname: Tatum
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Schnell
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology*; D001471:Barrett Esophagus / Q000453:epidemiology*; D018450:Disease Progression; D004938:Esophageal Neoplasms / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D015995:Prevalence; D054328:Proton Pump Inhibitors / Q000627:therapeutic use
chemical_list: D054328:Proton Pump Inhibitors