title: Effect of physical exercise on bone density and remodeling in egyptian type 1 diabetic osteopenic adolescents.
abstract: BACKGROUND
  The study was planned to assess effect of physical exercise on bone remodeling in type I diabetics with osteopenia.
  
  
  METHODS
  Twenty-four type I diabetes mellitus (DM1) with osteopenia (10 females and 14 males) were compared to thirty-eight age- and sex-matched healthy control individuals (20 females and 18 males) for biochemical and radiologic parameters of bone mass. Laboratory investigations included serum and urinary calcium, inorganic phosphorus, alkaline phosphatase, and serum "procollagen type 1 N-terminal propeptide (P1NP). Bone densitometry was assessed at neck femur using Dual Energy X-ray Absorptiometry (DEXA). Serum P1NP and DEXA were reevaluated after a planned exercise program.
  
  
  RESULTS
  Patients and controls were comparable with respect to serum as well as urinary biochemical parameters of bone mass namely; calcium, phosphorus and total serum alkaline phosphatase. Osteopenic DM1 patients displayed lower mean serum P1NP than control group (20.11 ± 6.72 ug\dL versus 64.96 ± 34.89 ug\dL; p < 0.05). A significant correlation was observed between BMD and degree of glycemic control reflected by serum glycated hemoglobin (r = -0.44, p, 0.030). Bone densitometry correlated with serum P1NP (r = -0.508, p, 0.011). After a planned regular exercise for 3 months, serum P1NP and BMD levels increased with percentage change of 40.88 ± 31.73 and 3.36 ± 2.94, respectively. Five patients resumed normal densitometry and they were all males.
  
  
  CONCLUSIONS
  Diabetic osteopenic patients displayed lower serum levels of procollagen type 1 N-terminal propeptide which reflects poor bone formation. A 3-months planned exercise program was associated with improvement of bone densitometry and significant increment of serum P1NP.
authors.affiliation: Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. elhabashysafinaz@yahoo.co.uk.
authors.forename: Safinaz A
authors.initials: SA
authors.lastname: Elhabashy
authors.forename: Omaima Mohamed
authors.initials: OM
authors.lastname: Said
authors.forename: Mervat Harvi
authors.initials: MH
authors.lastname: Agaiby
authors.forename: Amr A
authors.initials: AA
authors.lastname: Abdelrazek
authors.forename: Sayed
authors.initials: S
authors.lastname: Abdelhamid