title: Translocation mapping exposes the risky lifestyle of B cells.
abstract: Recurrent chromosomal translocations can drive oncogenesis, but how they form has remained elusive. Now, Chiarle et al. (2011) and Klein et al. (2011) characterize the genome-wide spectrum of translocations that form from a single double-stranded break, revealing that specific loci have an intrinsic predisposition for frequent chromosomal rearrangements.
authors.affiliation: Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605-0103, USA.
authors.forename: Rachel Patton
authors.initials: RP
authors.lastname: McCord
authors.forename: Job
authors.initials: J
authors.lastname: Dekker