title: Cortical-limbic regions modulate depression and anxiety factors in functional dyspepsia: a PET-CT study.
abstract: OBJECTIVE
  To observe some specific brain areas or cerebral functional network participating in the modulation of depression and anxiety factors in functional dyspepsia (FD) patients by detecting cerebral glucose metabolism (CGM) in fluorine-18 fluorodeoxyglucose ((18)F-FDG) positron emission tomography-computed tomography (PET-CT) scans.
  
  
  METHODS
  Eight FD patients with depression and anxiety (DA-FD group) and eight FD patients without depression and anxiety (non-DA-FD group) were recruited and evaluated by the Nepean Dyspepsia Index (NDI) and Dyspepsia Symptom Scores (DSS). Cerebral (18)F-FDG PET-CT scans were performed on the DA-FD group and non-DA-FD group, respectively. The differences in CGM between the two groups were analyzed with SPM2.
  
  
  RESULTS
  Extensive changes in the CGM signals were observed in the cerebral cortex and limbic system of FD patients with depression and anxiety. Compared to non-DA-FD patients, DA-FD patients showed a higher glucose metabolism in the right postcentral gyrus (BA 1 and 5), inferior frontal gyrus (BA 45), superior temporal gyrus (BA 22), middle temporal gyrus (BA 22), inferior parietal lobule (BA 40), lingual gyrus (BA 18) and the left middle occipital gyrus (BA 37), as well as the limbic system including the left thalamus, lateral globus pallidus, parahippocampal gyrus (BA 35), right insular cortex (BA 13) and parahippocampal gyrus (BA 18); a lower glucose metabolism was presented in the left middle cingulated gyrus (BA 24), the right superior frontal gyrus (BA 6), the medial frontal gyrus (BA 6) and middle temporal gyrus (BA 21).
  
  
  CONCLUSIONS
  An extensive cortical-limbic brain network might modulate the procession of FD patients with depression and anxiety factors.
authors.affiliation: Traditional Chinese Medicine of Chengdu University, Chengdu, China. liumailan2006@yahoo.com.cn
authors.forename: Mai-Lan
authors.initials: ML
authors.lastname: Liu
authors.forename: Fan-Rong
authors.initials: FR
authors.lastname: Liang
authors.forename: Fang
authors.initials: F
authors.lastname: Zeng
authors.forename: Yong
authors.initials: Y
authors.lastname: Tang
authors.forename: Lei
authors.initials: L
authors.lastname: Lan
authors.forename: Wen-Zhong
authors.initials: WZ
authors.lastname: Song
mesh_terms: D000328:Adult; D001007:Anxiety / Q000150:complications*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003863:Depression / Q000150:complications*; D004415:Dyspepsia / Q000150:complications / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D041981:Gastrointestinal Tract / Q000503:physiopathology; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008032:Limbic System / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D019788:Fluorodeoxyglucose F18; D005947:Glucose