title: [Small-world properties of glucose metabolism based brain functional network].
abstract: OBJECTIVE
  To establish a brain functional network of the whole brain based on glucose metabolism, and to evaluate the cost and efficiency of the functional network.
  
  
  METHODS
  18F-FDG PET of 148 healthy volunteers (30-59 years, n = 148) was performed in a resting state. Images were registered to atlas by using the statistical parametric mapping (SPM) software. The functional connectivity between 90 cortical and sub-cortical regions was estimated by correlation analysis.
  
  
  RESULTS
  Glucose metabolism brain functional networks had global efficiency greater than the lattice but less than the random graph, and local efficiency greater than random but less than lattice. This characteristically small-world behavior of the brain network was most consistently seen for low-cost to medium-cost networks. The small world regime was Cost-[0.0512, 0.5406]. The cost efficiency of the networks typically had a maximum positive value when the cost was 0.23.
  
  
  CONCLUSIONS
  Glucose metabolism brain functional networks have economical small-world properties. It is feasible to analyze the functional characteristics of human brain by study 18F-FDG PET images. This paper provides a new method for studies on brain function.
authors.affiliation: Department of Biomedical Engineering, School of Medicine, Shanghai Jiaotong University, Shanghai 200025. peggy_zhang@shsmu.edu.cn
authors.forename: Fang
authors.initials: F
authors.lastname: Zhang
authors.forename: Jiange
authors.initials: J
authors.lastname: Zhang
authors.forename: Chuantao
authors.initials: C
authors.lastname: Zuo
authors.forename: Wanhua
authors.initials: W
authors.lastname: Guo
authors.forename: Cheng
authors.initials: C
authors.lastname: Wang
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism* / Q000502:physiology; D001931:Brain Mapping; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D009415:Nerve Net; D049268:Positron-Emission Tomography / Q000379:methods*
chemical_list: D019788:Fluorodeoxyglucose F18; D005947:Glucose