title: STAT3 gene polymorphisms and susceptibility to non-small cell lung cancer.
abstract: Signal transducer and activator of transcription  protein 3 (STAT3) has been implicated in cancer development and is recognized  as a type of oncogene. However, association studies of single nucleotide polymorphisms  (SNPs) in the STAT3 gene with cancer risk are rare and not available for  lung cancer. We examined whether STAT3 polymorphisms are associated with  the risk of non-small cell lung cancer (NSCLC). Eight SNPs in the STAT3 gene  were genotyped by TaqMan assays in 326 NSCLC cases and 432 controls in a  Chinese population. Significant decreased risk of NSCLC was observed for  carriers of minor alleles rs4796793 (odds ratio (OR) = 0.68, 95% confidence  interval (CI) = 0.51-0.92), rs7211777 (OR = 0.67, 95%CI = 0.50-0.90),  rs12949918 (OR = 0.73, 95%CI = 0.54-0.97), rs744166 (OR = 0.69, 95%CI =  0.51-0.92), rs9912773 (OR = 0.75, 95%CI = 0.55-0.98), and rs3869550 (OR = 0.70,  95%CI = 0.53-0.94). The GGCGGC haplotype, comprised of minor alleles of the six  NSCLC-associated SNPs, had a 0.78-fold (95%CI = 0.62-0.97) significantly  decreased risk of NSCLC, as compared to the most common haplotype of CATACT.  Stratification analyses by clinical stage showed that the trend for the  association between STAT3 polymorphisms and NSCLC risk was present both  for stage I/II and stage III/IV, and appeared moderately stronger for stage  III/IV. We conclude that polymorphisms in the STAT3 gene may have a  protective role in the development of NSCLC, particular of stage III/IV NSCLC.
authors.affiliation: Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, PR China.
authors.forename: B
authors.initials: B
authors.lastname: Jiang
authors.forename: Z Z
authors.initials: ZZ
authors.lastname: Zhu
authors.forename: F
authors.initials: F
authors.lastname: Liu
authors.forename: L J
authors.initials: LJ
authors.lastname: Yang
authors.forename: W Y
authors.initials: WY
authors.lastname: Zhang
authors.forename: H H
authors.initials: HH
authors.lastname: Yuan
authors.forename: J G
authors.initials: JG
authors.lastname: Wang
authors.forename: X H
authors.initials: XH
authors.lastname: Hu
authors.forename: G
authors.initials: G
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D002681:China; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D012307:Risk Factors; D050796:STAT3 Transcription Factor / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics; D012907:Smoking
chemical_list: D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human