title: Pharmacologic therapy for nonvariceal upper gastrointestinal bleeding.
abstract: There are many clinical outcome measures for evaluation of the effectiveness of a pharmacologic agent in the management of upper gastrointestinal bleeding (UGIB). As a preemptive treatment, it should reduce the need for emergency endoscopy and endoscopic intervention, facilitate the efficient identification of the bleeding source and, hence, shorten procedure time and reduce the risk of procedure-related complications. As an effective adjunctive therapy after endoscopic hemostasis, it should reduce the incidence of recurrent bleeding and the need to repeat endoscopic hemostasis. This article provides an overview of different pharmacologic agents that have been used in the management of UGIB.
authors.affiliation: Institute of Digestive Disease, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin.
authors.forename: Justin C Y
authors.initials: JC
authors.lastname: Wu
authors.forename: Joseph J Y
authors.initials: JJ
authors.lastname: Sung
mesh_terms: D004917:Erythromycin / Q000008:administration & dosage / Q000627:therapeutic use; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy* / Q000208:ethnology; D016558:Hemostasis, Endoscopic; D006635:Histamine H2 Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D054328:Proton Pump Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D013004:Somatostatin / Q000031:analogs & derivatives*; D041742:Upper Gastrointestinal Tract / Q000187:drug effects*
chemical_list: D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors; D013004:Somatostatin; D004917:Erythromycin