title: Epigenetic control of macrophage polarization.
abstract: Epigenetic control of gene expression is critical for cellular differentiation and development. Macrophage development, polarization and activation are also controlled by DNA and histone modifications. This Viewpoint summarizes the recent findings on the role of histone modifications regulating macrophage polarization toward M1 and M2 subtypes.
authors.affiliation: Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Takeuch
authors.forename: Shizuo
authors.initials: S
authors.lastname: Akira
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D019070:Cell Lineage; D042002:Chromatin Assembly and Disassembly; D016207:Cytokines / Q000276:immunology*; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation / Q000276:immunology; D006657:Histones / Q000276:immunology*; D006801:Humans; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology*; D058408:Th1-Th2 Balance
chemical_list: D016207:Cytokines; D006657:Histones