title: Usefulness of pulmonary function tests and blood gases in acute neuromuscular respiratory failure.
abstract: OBJECTIVE
  Define the usefulness of pulmonary function tests (PFT) and arterial blood gases (ABG) in patients admitted to the ICU with acute neuromuscular respiratory failure (NMRF).
  
  
  METHODS
  We reviewed 76 patients admitted to an ICU at Mayo Clinic (Rochester) between 2003 and 2009 with acute NMRF defined as need for mechanical ventilation (MV) because of primary impairment of the peripheral nervous system. Poor functional outcome was defined as a modified Rankin score >3.
  
  
  RESULTS
  Median age was 65years. The most frequent diagnosis was myasthenia gravis (25 patients); 54% of patients had no known neuromuscular diagnosis before admission, and 11% had no specific diagnosis at discharge. Median MV time was 16days; 14% of patients died during hospitalization, and 63% were severely disabled at discharge. Maximal expiratory pressure ≤30cm H(2) O and maximal inspiratory pressure (MIP) worse than -28cm H2 O before MV were associated with need for invasive MV for longer than 7days (P=0.02). Indicators of chronic respiratory acidosis (low pH, high pCO2 , and high HCO3 ) before MV were associated with in-hospital death and poor functional outcome, but mostly in patients with progressive, untreatable neuromuscular diagnoses.
  
  
  CONCLUSIONS
  In patients with primary acute NMRF, bedside PFT and ABG before MV can be used to predict evolution and outcome. Lower MIP and MEP portend prolonged MV and are more useful than forced vital capacity. Presentation with chronic respiratory acidosis is associated with high risk of in-hospital mortality and severe disability, especially in patients without treatable diagnoses.
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: M
authors.initials: M
authors.lastname: Cabrera Serrano
authors.forename: A A
authors.initials: AA
authors.lastname: Rabinstein
mesh_terms: D000368:Aged; D001784:Blood Gas Analysis; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D009468:Neuromuscular Diseases / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D012121:Respiration, Artificial; D012129:Respiratory Function Tests; D012131:Respiratory Insufficiency / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy