title: Antibodies against lytic and latent Kaposi's sarcoma-associated herpes virus antigens and lymphoma in the European EpiLymph case-control study.
abstract: BACKGROUND
  Kaposi's sarcoma-associated herpes virus is associated with primary effusion lymphoma and multicentric Castleman's disease.
  
  
  METHODS
  Seropositivity to lytic and latent Kaposi's sarcoma herpes virus (KSHV) antigens were examined in 2083 lymphomas and 2013 controls from six European countries.
  
  
  RESULTS
  Antibodies against KSHV latent and lytic antigens were detectable in 4.5% and 3.4% of controls, respectively, and 3.6% of cases (P>0.05). The KSHV seropositivity was associated with splenic marginal zone lymphoma (SMZL) (odds ratio (OR)=4.11, 95% confidence interval (CI)=1.57-10.83) and multiple myeloma (OR=0.31, 95% CI=0.11-0.85).
  
  
  CONCLUSIONS
  The KSHV is unlikely to contribute importantly to lymphomagenesis among immunocompetent subjects. However, the observed association with SMZL may underline a chronic antigen mechanism in its aetiology.
authors.affiliation: Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Català d' Oncologia, IDIBELL, L' Hospitalet de Llobregat, Gran Via km.199-203, Barcelona, Spain.
authors.forename: Y
authors.initials: Y
authors.lastname: Benavente
authors.forename: G
authors.initials: G
authors.lastname: Mbisa
authors.forename: N
authors.initials: N
authors.lastname: Labo
authors.forename: D
authors.initials: D
authors.lastname: Casabonne
authors.forename: N
authors.initials: N
authors.lastname: Becker
authors.forename: M
authors.initials: M
authors.lastname: Maynadie
authors.forename: L
authors.initials: L
authors.lastname: Foretova
authors.forename: P L
authors.initials: PL
authors.lastname: Cocco
authors.forename: A
authors.initials: A
authors.lastname: Nieters
authors.forename: A
authors.initials: A
authors.lastname: Staines
authors.forename: P
authors.initials: P
authors.lastname: Bofetta
authors.forename: P
authors.initials: P
authors.lastname: Brennan
authors.forename: D
authors.initials: D
authors.lastname: Whitby
authors.forename: S
authors.initials: S
authors.lastname: de Sanjosé
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000906:Antibodies / Q000276:immunology*; D000956:Antigens, Viral / Q000276:immunology*; D016022:Case-Control Studies; D005871:Castleman Disease / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005060:Europe; D005260:Female; D019288:Herpesvirus 8, Human / Q000276:immunology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology* / Q000821:virology; D054685:Lymphoma, Primary Effusion / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012514:Sarcoma, Kaposi / Q000276:immunology*; D055815:Young Adult
chemical_list: D000906:Antibodies; D000956:Antigens, Viral