title: Carbonyl group serum levels are associated with CD38 expression in patients with B chronic lymphocytic leukemia.
abstract: OBJECTIVE
  To evaluate carbonyl groups (CG) serum levels in B-chronic lymphocytic leukemia (B-CLL) patients.
  
  
  METHODS
  CG serum levels were assessed in 48 B-CLL patients and in 30 control subjects.
  
  
  RESULTS
  CG were increased in B-CLL patients. We found a positive correlation between CG with CD38 expression and a negative correlation with ZAP 70 expression.
  
  
  CONCLUSIONS
  B-CLL patients displayed an unbalance of the oxidative stress. CG serum levels could be considered as a prognostic factor in B-CLL.
authors.affiliation: Division of Haematology, University of Messina, Messina, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Musolino
authors.forename: Alessandro
authors.initials: A
authors.lastname: Allegra
authors.forename: Andrea
authors.initials: A
authors.lastname: Alonci
authors.forename: Antonella
authors.initials: A
authors.lastname: Saija
authors.forename: Sabina
authors.initials: S
authors.lastname: Russo
authors.forename: Antonino
authors.initials: A
authors.lastname: Cannavò
authors.forename: Mariateresa
authors.initials: M
authors.lastname: Cristani
authors.forename: Raffaella
authors.initials: R
authors.lastname: Centorrino
authors.forename: Salvatore
authors.initials: S
authors.lastname: Saitta
authors.forename: Angela
authors.initials: A
authors.lastname: Alibrandi
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Gangemi
mesh_terms: D051997:ADP-ribosyl Cyclase 1; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D001798:Blood Proteins / Q000378:metabolism*; D002374:Catalase / Q000097:blood; D005260:Female; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007135:Immunoglobulin Variable Region / Q000235:genetics; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008562:Membrane Glycoproteins; D008875:Middle Aged; D009367:Neoplasm Staging; D018384:Oxidative Stress; D011379:Prognosis; D050050:Protein Carbonylation; D051746:ZAP-70 Protein-Tyrosine Kinase / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D001798:Blood Proteins; D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region; D008562:Membrane Glycoproteins; D008315:Malondialdehyde; D002374:Catalase; D051746:ZAP-70 Protein-Tyrosine Kinase; C498154:CD38 protein, human; D051997:ADP-ribosyl Cyclase 1