title: Modular kinetic analysis.
abstract: Modularization is an important strategy to tackle the study of complex biological systems. Modular kinetic analysis (MKA) is a quantitative method to extract kinetic information from such a modularized system that can be used to determine the control and regulatory structure of the system, and to pinpoint and quantify the interaction of effectors with the system. The principles of the method are described, and the relation with metabolic control analysis is discussed. Examples of application of MKA are given.
authors.affiliation: Department of Molecular Cell Physiology, IMC, Faculty of Earth and Life Sciences, Vrije Universiteit, De Boelelaan 1085, Amsterdam, The Netherlands.
authors.forename: Klaas
authors.initials: K
authors.lastname: Krab
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000465:Algorithms; D000818:Animals; D019069:Cell Respiration; D006801:Humans; D007700:Kinetics; D053078:Membrane Potential, Mitochondrial; D053858:Metabolic Networks and Pathways; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D010085:Oxidative Phosphorylation
chemical_list: D000255:Adenosine Triphosphate