title: Protein degradation: BAGging up the trash.
abstract: Cells efficiently uncover and degrade proteins that are misfolded. However, we know very little about what cells do to protect themselves from mislocalized proteins. A new study reveals a novel quality control pathway that recognizes and degrades secretory pathway proteins that have failed to target to the endoplasmic reticulum.
authors.affiliation: Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.
authors.forename: Tslil
authors.initials: T
authors.lastname: Ast
authors.forename: Maya
authors.initials: M
authors.lastname: Schuldiner
mesh_terms: D003593:Cytoplasm / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D018832:Molecular Chaperones / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D011328:Prions / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex; D017510:Protein Folding; D021382:Protein Sorting Signals; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D059748:Proteolysis; D025801:Ubiquitin / Q000378:metabolism; D054875:Ubiquitination
chemical_list: C092009:BAG6 protein, human; D018832:Molecular Chaperones; D011328:Prions; D021382:Protein Sorting Signals; D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex