title: Anti-hyperglycemic activity of leaves extract of Hyptis suaveolens L. Poit in streptozotocin induced diabetic rats.
abstract: OBJECTIVE
  To evaluate the antihyperglycemic activity of leaves of Hyptis suaveolens using streptozotocin model.
  
  
  METHODS
  Hyptis suaveolens extract (HSE) 250 and 500 mg/kg body weight was administered orally to streptozotocin induced diabetes, once daily for 21 days.
  
  
  RESULTS
  A significant reduction in blood glucose was observed in diabetic animals treated with HSE at different doses when compared with diabetic rats. Levels of triglyceride, total cholesterol, low density lipoprotein, very low density lipoprotein were decreased while administering HSE at different doses, compared with their control values in diabetic animals.
  
  
  CONCLUSIONS
  Our results show that HSE possesses significant antihyperglycemic activity which might be attributed to stimulating effects on glucose utilization and antioxidant enzyme.
authors.affiliation: United Institute of Pharmacy, UCER, Allahabad, India. shantipharma15@gmail.com
authors.forename: Shanti Bhushan
authors.initials: SB
authors.lastname: Mishra
authors.forename: Amita
authors.initials: A
authors.lastname: Verma
authors.forename: Alok
authors.initials: A
authors.lastname: Mukerjee
authors.forename: M
authors.initials: M
authors.lastname: Vijayakumar
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D031331:Hyptis / Q000737:chemistry*; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D014280:Triglycerides; D013311:Streptozocin; D002784:Cholesterol