title: Carbon-carbon bond-forming enzymes for the synthesis of non-natural amino acids.
abstract: An enzymatic methodology for the preparation of β-hydroxy-α-amino acid derivatives is described. The method consists of the stereoselective aldol addition reaction of glycine to N-Cbz-amino aldehydes furnishing 3-hydroxy-2,4-diaminobutyric derivatives.
authors.affiliation: Department of Chemical Biology and Molecular Modeling, Instituto de Química Avanzada de Cataluña IQAC-CSIC, Barcelona, Spain. pere.clapes@iqac.csic.es
authors.forename: Pere
authors.initials: P
authors.lastname: Clapés
authors.forename: Jesús
authors.initials: J
authors.lastname: Joglar
authors.forename: Mariana
authors.initials: M
authors.lastname: Gutiérrez
mesh_terms: D000596:Amino Acids / Q000096:biosynthesis*; D001483:Base Sequence; D002244:Carbon / Q000378:metabolism*; D017931:DNA Primers; D012696:Glycine Hydroxymethyltransferase / Q000378:metabolism*; D016133:Polymerase Chain Reaction
chemical_list: D000596:Amino Acids; D017931:DNA Primers; D002244:Carbon; D012696:Glycine Hydroxymethyltransferase