title: [Effect of indometofen on the survival and bone marrow hemopoiesis of mice exposed to acute external gamma- or X-ray irradiation].
abstract: The purpose of the study is evaluation of radioprotective effectiveness of indometofen at its prophylactic administration in conditions of acute irradiation. Evaluation of radioprotective efficiency was performed by studying the 30-day survival rate, life expectancy, structure of deathly irradiated mice, and bone marrow hemopoiesis using methods of endogenous and exogenous colony formation. The prophylactic application of indometofen at doses 30 mg/kg for 5 days before irradiation has been observed to protect mice against radiation death induced by gamma or X-ray exposures at doses LD(50-70/30), increasing their survival rate by 16-44%, and reduce severity of post radiation disorders of bone marrow hemopoiesis.
authors.forename: A N
authors.initials: AN
authors.lastname: Grebeniuk
authors.forename: V N
authors.initials: VN
authors.lastname: Bykov
authors.forename: V A
authors.initials: VA
authors.lastname: Miasnikov
authors.forename: V V
authors.initials: VV
authors.lastname: Zatsepin
authors.forename: N V
authors.initials: NV
authors.lastname: Aksenova
authors.forename: I S
authors.initials: IS
authors.lastname: Drachev
authors.forename: E B
authors.initials: EB
authors.lastname: Suprunova
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000528:radiation effects; D005720:Gamma Rays; D006410:Hematopoiesis / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011829:Radiation Dosage; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013629:Tamoxifen / Q000031:analogs & derivatives* / Q000494:pharmacology; D014965:X-Rays
chemical_list: D011837:Radiation-Protective Agents; C091454:indometafen; D013629:Tamoxifen