title: [Transcriptional analysis of the Grp gene, a genomic homolog of the retrotransposon gypsy gag gene, in Drosophila melanogaster].
abstract: In the present work, we studied the Grp gene (CG4680, Gag related protein) expression at the transcriptional level. It was found that at the embryonic and larval stages of D. melanogaster development the Grp expression proceeds at a low level, but it significantly increases at the adult stage. Adult individuals display a tissue-specific expression: an eleveated level of transcription is observed in the gut tissues, but not in the chitin carcass, head, and gonads. Since the gut may potentially be a primary barrier for the penetration of a viral infection, we conducted a comparative analysis of Grp gene transcription in D. melanogaster strains differing in the presence of active copies of the gypsy errantivirus and in the status of the flamenco gene controlling sensitivity to errantiviral infections. No noticeable differences in the level of Grp gene transcription were revealed. Thus, the Grp gene is not a pseudogene, but it is a functional gene of the D. melanogaster genome whose role remains to be elucidated.
authors.forename: L N
authors.initials: LN
authors.lastname: Nefedova
authors.forename: I V
authors.initials: IV
authors.lastname: Kuz'min
authors.forename: D A
authors.initials: DA
authors.lastname: Burmistrova
authors.forename: S
authors.initials: S
authors.lastname: Rezazadekh
authors.forename: A I
authors.initials: AI
authors.lastname: Kim
mesh_terms: D000818:Animals; D000071877:Checkpoint Kinase 1; D029721:Drosophila Proteins; D004331:Drosophila melanogaster; D018507:Gene Expression Regulation, Developmental; D015683:Gene Products, gag / Q000235:genetics / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000196:embryology / Q000821:virology; D009928:Organ Specificity / Q000235:genetics; D011494:Protein Kinases / Q000096:biosynthesis* / Q000235:genetics; D018626:Retroelements; D012190:Retroviridae / Q000235:genetics / Q000378:metabolism*; D012192:Retroviridae Infections / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D029721:Drosophila Proteins; D015683:Gene Products, gag; D018626:Retroelements; D011494:Protein Kinases; D000071877:Checkpoint Kinase 1; C000605877:grp protein, Drosophila