title: PLA/ β-TCP complex tubes: the mechanical properties and applications of artificial bone.
abstract: Poly(lactic acid) (PLA) twisted yarn was braided into a 6-layered, hollow, cylindrical braid on a 16-spindle braid machine. The PLA braid was then placed inside a β-TCP tube, forming the PLA/β-TCP complex tube which imitates the porous structure of sponge bone. Different components and structures were studied to determine the best bone molding material. The β-TCP tube was created by sintering TCP powder mixed with stearic acid in a ratio of 1:1.5 to form a highly porous and well-structured tube with interconnected pores; its resulting porosity was 85.8 ± 0.93%. The PLA/β-TCP complex tube was implanted in a rabbit's femur and after 3 months a marrow cavity was discovered at the tube's core. New bone was also observed, regenerating around the PLA braid within the PLA/β-TCP complex tube.
authors.affiliation: a Institute of Biomedical Engineering and Material Science, Central Taiwan University of Science and Technology , Taichung , 40601 , Taiwan, ROC.
authors.forename: Ching-Wen
authors.initials: CW
authors.lastname: Lou
authors.forename: Chun-Hsu
authors.initials: CH
authors.lastname: Yao
authors.forename: Yueh-Sheng
authors.initials: YS
authors.lastname: Chen
authors.forename: Chao-Tsang
authors.initials: CT
authors.lastname: Lu
authors.forename: Wen-Cheng
authors.initials: WC
authors.lastname: Chen
authors.forename: Ke-Chung
authors.initials: KC
authors.lastname: Yen
authors.forename: Jia-Horng
authors.initials: JH
authors.lastname: Lin
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000737:chemistry; D002130:Calcium Phosphates / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival; D018920:Coculture Techniques; D004195:Disease Models, Animal; D005269:Femur / Q000293:injuries / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D011091:Polyesters; D011108:Polymers / Q000737:chemistry; D016062:Porosity; D011817:Rabbits; D013229:Stearic Acids / Q000737:chemistry; D023822:Tissue Engineering / Q000295:instrumentation / Q000379:methods
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; D011091:Polyesters; D011108:Polymers; D013229:Stearic Acids; C485817:beta-tricalcium phosphate; D019344:Lactic Acid; C033616:poly(lactide); C031183:stearic acid