title: Curative effect of topical treatment of digital dermatitis with a gel containing activated copper and zinc chelate.
abstract: The efficacy of two topical treatments for painful ulcerative stage (M2) of bovine digital dermatitis (BDD) lesions was compared in a clinical trial conducted on five dairy farms in 2009 to 2010. The first treatment was a water-based gel with active components copper and zinc (Intra Hoof-fit gel [IHF]) and the second treatment was a topical chlortetracycline spray (CTC spray). The experimental unit for this study was the hindleg with the presence of a BDD lesion. Cure was defined as the transition of an M2 lesion into a healed (M0) or a non-painful chronic stage (M4) of BDD at D28. On day 0, cows with M2 BDD lesions were photographed and were treated with either IHF or CTC. Subsequently, feet were photographed and scored on D28. The cure rate of M2 BDD lesions treated with IHF at D28 was 0.92 (CI 0.84 to 0.96) and was significantly better than for M2 BDD lesions treated with CTC, which was 0.58 (CI 0.47 to 0.68).
authors.affiliation: GD Deventer, Ruminant Health Department, Deventer, The Netherlands. m.holzhauer@gddeventer.com
authors.forename: M
authors.initials: M
authors.lastname: Holzhauer
authors.forename: C J
authors.initials: CJ
authors.lastname: Bartels
authors.forename: M
authors.initials: M
authors.lastname: van Barneveld
authors.forename: C
authors.initials: C
authors.lastname: Vulders
authors.forename: T
authors.initials: T
authors.lastname: Lam
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D015913:Chelation Therapy / Q000379:methods / Q000662:veterinary*; D003300:Copper / Q000008:administration & dosage / Q000627:therapeutic use*; D058066:Digital Dermatitis / Q000188:drug therapy*; D005260:Female; D005782:Gels; D006724:Hoof and Claw / Q000187:drug effects / Q000473:pathology; D016896:Treatment Outcome; D015032:Zinc / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D005782:Gels; D003300:Copper; D015032:Zinc