title: The effect of quinapril treatment on insulin resistance, leptin and high sensitive C-reactive protein in hypertensive patients.
abstract: The aim of the study was to evaluate the effect of quinapril on HOMA-IR, high sensitive C-reactive protein and leptin. Total 54 hypertensive and 24 control subjects were included in this study. Blood pressure, leptin, high sensitive C-reactive protein, and HOMA-IR were determined at baseline and after 3 months quinapril treatment. After treatment with quinapril HOMA-IR (p = 0.04), high sensitive C-reactive protein (p = 0.027), and leptin (p = 0.046) were decreased in hypertensive patients. Quinapril may be used as a therapy for improving blood pressure as well as the insulin resistant, hyperleptinemic, and low-grade inflammatory state in hypertension.
authors.affiliation: Division of Nephrology, Antalya Education and Research Hospital, Ministry of Health, Turkey.
authors.forename: Funda
authors.initials: F
authors.lastname: Sari
authors.forename: Esin
authors.initials: E
authors.lastname: Eray
authors.forename: Ramazan
authors.initials: R
authors.lastname: Sari
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage; D001794:Blood Pressure / Q000187:drug effects; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism*; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D000077583:Quinapril; D044005:Tetrahydroisoquinolines / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D020738:Leptin; D044005:Tetrahydroisoquinolines; D002097:C-Reactive Protein; D000077583:Quinapril