title: [Characteristics of endothelium hemodynamics and functional condition of hypertensive patients in high mountains].
abstract: Hemodynamics, geometry of the left myocardium ventricle (LV), blood nitrogen oxide and their interdependence were studied in hypertensive (n = 90) and normal mountain dwellers (n = 40) at the age of 37 to 72 years. The patients underwent general clinical and outpatient examination, electro- and echocardiography. The hypertensive patients were diagnosed for disorders in endothelium functioning, intracardiac hemodynamics, and LV geometry. In patients with class II and II hypertension, LV volumetric parameters were enlarged and contractility parameters decreased by 29%. Also, indices of LV mass, relative wall thickness and sphericity in these patients were significantly higher as compared with normal people. Blood concentration of nitrogen oxide was reduced by 28% and 40% in patients with hypertension class II and III, respectively. This reduction was caused disbalance of NO plasma metabolites and erythrocytes. All together data from the groups of equally patients and normal people suggests a particular role of nitrogen oxide in controlling myocardium LV hemodynamics and geometry in hypertensive mountain dwellers.
authors.forename: M Kh
authors.initials: MKh
authors.lastname: Kurdanova
authors.forename: I A
authors.initials: IA
authors.lastname: Beslaneev
authors.forename: L M
authors.initials: LM
authors.lastname: Batyrbekova
authors.forename: Kh A
authors.initials: KhA
authors.lastname: Kurdanov
mesh_terms: D000328:Adult; D000531:Altitude; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood / Q000502:physiology*; D014463:Ultrasonography; D016277:Ventricular Function, Left
chemical_list: D009569:Nitric Oxide