title: Effects of cytokinins, cytokinin ribosides and their analogs on the viability of normal and neoplastic human cells.
abstract: We examined the effects of some cytokinins and cytokinin ribosides including a series of adenosine analogs differently substituted in the N(6) position, along with some hypoxanthine derivatives on the viability of normal and neoplastic human cells. Cytokinins such as trans-zeatin, isopentenyladenine and benzyladenine do not show any effect, while cytokinin ribosides such as trans-zeatin riboside, isopentenyladenosine, and benzylaminopurine riboside impair the viability of normal and neoplastic cells, apart from colon carcinoma LoVo cells.
authors.affiliation: Dipartimento di Scienze Cliniche "Luigi Sacco", Università degli Studi di Milano, Via G.B. Grassi, 74 - 20157 Milano, Italy.
authors.forename: Silvana
authors.initials: S
authors.lastname: Casati
authors.forename: Roberta
authors.initials: R
authors.lastname: Ottria
authors.forename: Erika
authors.initials: E
authors.lastname: Baldoli
authors.forename: Elisa
authors.initials: E
authors.lastname: Lopez
authors.forename: Jeanette A M
authors.initials: JA
authors.lastname: Maier
authors.forename: Pierangela
authors.initials: P
authors.lastname: Ciuffreda
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology; D003583:Cytokinins / Q000737:chemistry / Q000494:pharmacology*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007541:Isopentenyladenosine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D009369:Neoplasms / Q000473:pathology*; D009499:Neutral Red / Q000378:metabolism; D012263:Ribonucleosides / Q000737:chemistry / Q000494:pharmacology*; D014410:Tumor Stem Cell Assay; D015026:Zeatin / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D003583:Cytokinins; D012263:Ribonucleosides; D009499:Neutral Red; C017061:N(6)-benzyladenosine; D007541:Isopentenyladenosine; D015026:Zeatin; C009699:zeatin riboside; D000241:Adenosine; D002945:Cisplatin