title: Bone healing and osteoporosis.
abstract: A correct fracture healing depends on the synergy between biomechanical, molecular and cellular factors. Focusing on different stages, fracture hematoma represents the starting point of the inflammatory process, with a critical role in triggering the process of fracture healing. The essential factors for bone repair are the activation of mesenchymal stem cells and the release of growth and regulatory factors. Moreover, the efficacy of fracture healing is determined by three ideal conditions: adequate blood supply, good contact between bone fragments and good stability. It is remarkable how the implant choice influences fracture healing after surgical treatment. In osteoporosis, bone quality adversely affects the tissue structural competence, increasing the risk of a complicated fracture healing. The qualitative and quantitative alterations established at the cellular level during osteoporosis explain the progressive deterioration of bone tissue healing ability.
authors.affiliation: Orthopaedics and Traumatology, PTV Foundation, University of Tor Vergata, Rome, Italy. umberto.tarantino@uniroma2.it
authors.forename: Umberto
authors.initials: U
authors.lastname: Tarantino
authors.forename: Irene
authors.initials: I
authors.lastname: Cerocchi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Scialdoni
authors.forename: Luca
authors.initials: L
authors.lastname: Saturnino
authors.forename: Maurizio
authors.initials: M
authors.lastname: Feola
authors.forename: Monica
authors.initials: M
authors.lastname: Celi
authors.forename: Federico Maria
authors.initials: FM
authors.lastname: Liuni
authors.forename: Giovanni
authors.initials: G
authors.lastname: Iolascon
authors.forename: Elena
authors.initials: E
authors.lastname: Gasbarra
mesh_terms: D000368:Aged; D000375:Aging; D001696:Biomechanical Phenomena; D015519:Bone Density; D001842:Bone and Bones / Q000473:pathology*; D005260:Female; D017102:Fracture Healing; D006801:Humans; D010024:Osteoporosis / Q000473:pathology / Q000503:physiopathology*; D015663:Osteoporosis, Postmenopausal / Q000473:pathology; D058866:Osteoporotic Fractures / Q000503:physiopathology