title: Cardiovascular and metabolic safety profiles of the fluoroquinolones.
abstract: BACKGROUND
  Certain fluoroquinolones share similar indications of use. A comparison among Cardiovascular and metabolic (i.e., dysglycemia) safety profiles of the fluoroquinolones might be particularly useful for the prescribers' decision-making process as well as to hypothesize future researcher purposes.
  
  
  METHODS
  A literature search was conducted using keywords apt to identify information on safety profile of the fluoroquinolones. Publications concerned with descriptive and etiological surveys were manually reviewed.
  
  
  CONCLUSIONS
  Cardiac alterations and blood glucose impairments might be associated with any fluoroquinolone. However, the benefit/risk profile of these agents could be stratified for the single compounds. Several predisposing factors, such as diabetes, heart illnesses and their related pharmacotherapies, might exacerbate the risk of potentially serious adverse events. In this context, the opportunity of the more appropriate choice among different fluoroquinolones could be applicable.
authors.affiliation: University of Florence, Department of Pharmacology, Viale Pieraccini 6, 50139, Florence, Italy. francesco.lapi@unifi.it
authors.forename: Alessandra
authors.initials: A
authors.lastname: Pugi
authors.forename: Loreta
authors.initials: L
authors.lastname: Longo
authors.forename: Alessandro
authors.initials: A
authors.lastname: Bartoloni
authors.forename: Gian Maria
authors.initials: GM
authors.lastname: Rossolini
authors.forename: Alessandro
authors.initials: A
authors.lastname: Mugelli
authors.forename: Alfredo
authors.initials: A
authors.lastname: Vannacci
authors.forename: Francesco
authors.initials: F
authors.lastname: Lapi
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use; D001786:Blood Glucose / Q000187:drug effects*; D002318:Cardiovascular Diseases / Q000139:chemically induced*; D003920:Diabetes Mellitus / Q000453:epidemiology; D024841:Fluoroquinolones / Q000009:adverse effects* / Q000627:therapeutic use; D006331:Heart Diseases / Q000150:complications; D006801:Humans; D012307:Risk Factors
chemical_list: D000900:Anti-Bacterial Agents; D001786:Blood Glucose; D024841:Fluoroquinolones