title: Relationship between circulating cytokine levels and physical or psychological functioning in patients with advanced cancer.
abstract: OBJECTIVE
  To investigate the relation between functional impairments of cancer patients and circulating cytokines using a multiplex technique.
  
  
  METHODS
  50 patients with cancer were assessed using the quality of life (QOL) questionnaire. 27 plasma cytokine levels were determined by using the Bio-Plex array system. The relation to QOL scores was assessed using Chi-square test for categorical variables and univariate linear regression analysis for cytokine levels.
  
  
  RESULTS
  Multivariate analysis showed that interleukin-6 (IL-6) level is a significant independent determinant of physical (β=-0.238, P=0.0126) and cognitive functioning (β=-0.462, P=0.0006) and that vascular endothelial growth factor (VEGF) level is a significant independent determinant of emotional functioning (β=-0.414, P=0.039).
  
  
  CONCLUSIONS
  This study, in which 27 cytokines are simultaneously tested with cutting edge technology, demonstrates that plasma IL-6 and VEGF are significant independent determinants of functional impairments in patients with cancer.
authors.affiliation: Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kokura
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Sakamoto
authors.forename: Manabu
authors.initials: M
authors.lastname: Okajima
authors.forename: Tatsuzo
authors.initials: T
authors.lastname: Matsuyama
authors.forename: Hiromi
authors.initials: H
authors.lastname: Sakai
authors.forename: Yoko
authors.initials: Y
authors.lastname: Okumura
authors.forename: Satoko
authors.initials: S
authors.lastname: Adachi
authors.forename: Naohisa
authors.initials: N
authors.lastname: Yoshida
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Uchiyama
authors.forename: Osamu
authors.initials: O
authors.lastname: Handa
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Takagi
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Konishi
authors.forename: Naoki
authors.initials: N
authors.lastname: Wakabayashi
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Yagi
authors.forename: Takashi
authors.initials: T
authors.lastname: Ando
authors.forename: Kazuko
authors.initials: K
authors.lastname: Uno
authors.forename: Yuji
authors.initials: Y
authors.lastname: Naito
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Yoshikawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003071:Cognition; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009369:Neoplasms / Q000097:blood* / Q000473:pathology / Q000503:physiopathology / Q000523:psychology*; D012044:Regression Analysis; D055815:Young Adult
chemical_list: D016207:Cytokines