title: Glutathione depletion prevents diet-induced obesity and enhances insulin sensitivity.
abstract: Excessive accumulation of reactive oxygen species (ROS) in adipose tissue has been implicated in the development of insulin resistance and type 2 diabetes. However, emerging evidence suggests a physiologic role of ROS in cellular signaling and insulin sensitivity. In this study, we demonstrate that pharmacologic depletion of the antioxidant glutathione in mice prevents diet-induced obesity, increases energy expenditure and locomotor activity, and enhances insulin sensitivity. These observations support a beneficial role of ROS in glucose homeostasis and warrant further research to define the regulation of metabolism and energy balance by ROS.
authors.affiliation: Saha Cardiovascular Research Center, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
authors.forename: Hannes M
authors.initials: HM
authors.lastname: Findeisen
authors.forename: Florence
authors.initials: F
authors.lastname: Gizard
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhao
authors.forename: Hua
authors.initials: H
authors.lastname: Qing
authors.forename: Karrie L
authors.initials: KL
authors.lastname: Jones
authors.forename: Dianne
authors.initials: D
authors.lastname: Cohn
authors.forename: Elizabeth B
authors.initials: EB
authors.lastname: Heywood
authors.forename: Dennis
authors.initials: D
authors.lastname: Bruemmer
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001522:Behavior, Animal; D001786:Blood Glucose / Q000378:metabolism; D004032:Diet / Q000009:adverse effects*; D004734:Energy Metabolism; D005978:Glutathione / Q000378:metabolism*; D006706:Homeostasis; D007333:Insulin Resistance; D008124:Locomotion; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000209:etiology / Q000517:prevention & control*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D017382:Reactive Oxygen Species; D005978:Glutathione