title: Design and synthesis of biotinylated DHMEQ for direct identification of its target NF-κB components.
abstract: The design and synthesis of dehydroxymethylepoxyquinomicin (DHMEQ) derivatives were carried out to investigate the intracellular targets. The synthetic biotin probe exhibited membrane permeability and combined selectively with the target protein p65.
authors.affiliation: Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Kohoku-ku, Yokohama 223-8522, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Saitoh
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Takeiri
authors.forename: Yuko
authors.initials: Y
authors.lastname: Gotoh
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ishikawa
authors.forename: Kazuo
authors.initials: K
authors.lastname: Umezawa
authors.forename: Shigeru
authors.initials: S
authors.lastname: Nishiyama
mesh_terms: D001549:Benzamides / Q000737:chemistry / Q000494:pharmacology*; D001710:Biotin / Q000737:chemistry*; D003512:Cyclohexanones / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D016328:NF-kappa B / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D001549:Benzamides; D003512:Cyclohexanones; D016328:NF-kappa B; C464444:dehydroxymethylepoxyquinomicin; D001710:Biotin