title: Hiding the road signs that lead to tumor immunity.
abstract: Tumors exploit many strategies to evade T cell-mediated destruction. For example, tumors can prevent T cell infiltration by modifying gene expression in the endothelial cells and pericytes that form their vasculature. New work showing that the T cell-attracting chemokine CCL2 can be posttranslationally modified in the tumor microenvironment adds another mechanism to the already formidable arsenal of immunoevasion tactics used by solid tumors.
authors.affiliation: Swim Across America Laboratory, Immunology Program, Sloan-Kettering Institute for Cancer Research, New York, NY, USA. schaerd@mskcc.org
authors.forename: David A
authors.initials: DA
authors.lastname: Schaer
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Lesokhin
authors.forename: Jedd D
authors.initials: JD
authors.lastname: Wolchok
mesh_terms: D018932:Chemokine CCL2 / Q000276:immunology; D006801:Humans; D016219:Immunotherapy, Adoptive; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology*; D026361:Reactive Nitrogen Species / Q000378:metabolism; D054390:Receptors, CCR2 / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D059016:Tumor Microenvironment
chemical_list: D018932:Chemokine CCL2; D026361:Reactive Nitrogen Species; D054390:Receptors, CCR2