title: Luminescent Ir(III) complex exclusively made of polypyridine ligands capable of intercalating into calf-thymus DNA.
abstract: Efficient intercalation of a luminescent Ir(III) complex exclusively made of polypyridine ligands in natural and synthetic biopolymers is reported for the first time. The emission of the complex is largely enhanced in the presence of [poly(dA-dT)(2)] and strongly quenched in the presence of [poly(dG-dC)(2)]. By comparing the emission decays in DNA and in synthetic polynucleotides, it is proposed that the emission quenching of the title compound by guanine residues in DNA is no longer effective over a distance of four dA-dT base pairs.
authors.affiliation: Dipartimento di Chimica Inorganica, Chimica Analitica e Chimica Fisica, Università di Messina, Via F. Stagno D'Alcontres 31, 98166 Messina, Italy. campagna@unime.it
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Campagna
authors.forename: Marco
authors.initials: M
authors.lastname: Cavazzini
authors.forename: Matteo
authors.initials: M
authors.lastname: Cusumano
authors.forename: Maria Letizia
authors.initials: ML
authors.lastname: Di Pietro
authors.forename: Antonino
authors.initials: A
authors.lastname: Giannetto
authors.forename: Fausto
authors.initials: F
authors.lastname: Puntoriero
authors.forename: Silvio
authors.initials: S
authors.lastname: Quici
mesh_terms: D001704:Biopolymers / Q000737:chemistry / Q000378:metabolism; D002942:Circular Dichroism; D004247:DNA / Q000378:metabolism*; D007364:Intercalating Agents / Q000032:analysis / Q000138:chemical synthesis* / Q000378:metabolism; D007495:Iridium / Q000737:chemistry*; D008024:Ligands; D049449:Luminescence; D008958:Models, Molecular; D015335:Molecular Probes / Q000032:analysis / Q000138:chemical synthesis* / Q000378:metabolism; D011067:Poly dA-dT / Q000737:chemistry / Q000378:metabolism; D011089:Polydeoxyribonucleotides / Q000737:chemistry / Q000378:metabolism; D058105:Polymerization; D011119:Polynucleotides / Q000737:chemistry / Q000378:metabolism; D011725:Pyridines / Q000737:chemistry*
chemical_list: D001704:Biopolymers; D007364:Intercalating Agents; D008024:Ligands; D015335:Molecular Probes; D011089:Polydeoxyribonucleotides; D011119:Polynucleotides; D011725:Pyridines; D011067:Poly dA-dT; C019530:poly(dC-dG); D007495:Iridium; D004247:DNA; C427203:calf thymus DNA; C023666:pyridine