title: A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and steroid-sensitive nephrotic syndrome in children.
abstract: OBJECTIVE
  Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism correlates with circulating and cellular ACE concentration. Association between ACE I/D gene polymorphism and steroid-sensitive nephrotic syndrome (SSNS) risk in children is still controversial. This meta-analysis was performed to evaluate the relation between ACE I/D gene polymorphism and SSNS susceptibility in children.
  
  
  METHODS
  The relevant investigations were screened from the search engines of PubMed, Cochrane Library and CBM-disc (China Biological Medicine Database) as of 1 March 2011, and eligible studies were synthesized using meta-analysis methods.
  
  
  RESULTS
  Ten studies were identified for the analysis of association between ACE I/D gene polymorphism and SSNS risk in children, including seven in Asians, one for Caucasians and two in Africans. There was no markedly positive association between D allele or DD genotype and SSNS susceptibility in Asians, Caucasians and Africans (D: Asians OR = 1.24, p = 0.28; Caucasians OR = 1.61, p = 0.15; Africans OR = 1.61, p = 0.53; DD: Asians OR = 1.72, p = 0.15; Caucasians OR = 1.39, p = 0.48; Africans OR = 1.80, p = 0.56). Furthermore, II homozygous seemed not to play a protective role against SSNS onset for Asians, Caucasians and Africans (Asians OR = 0.95, p = 0.85; Caucasians OR = 0.30, p = 0.11; Africans OR = 0.60, p = 0.65).
  
  
  CONCLUSIONS
  There was no association between ACE I/D gene polymorphism and SSNS susceptibility in Asians, Caucasians and Africans. However, the conclusions for Caucasians and Africans were less powerful.
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital of GuangXi Medical University, NanNing, China. a126tianbiao@126.com
authors.forename: Tian-Biao
authors.initials: TB
authors.lastname: Zhou
authors.forename: Yuan-Han
authors.initials: YH
authors.lastname: Qin
authors.forename: Chao
authors.initials: C
authors.lastname: Ou
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Su
authors.forename: Feng-Ying
authors.initials: FY
authors.lastname: Lei
authors.forename: Wei-Fang
authors.initials: WF
authors.lastname: Huang
authors.forename: Yan-Jun
authors.initials: YJ
authors.lastname: Zhao
authors.forename: Yu-Sheng
authors.initials: YS
authors.lastname: Pang
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D002648:Child; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006720:Homozygote; D006801:Humans; D054643:INDEL Mutation / Q000235:genetics*; D009404:Nephrotic Syndrome / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013256:Steroids / Q000627:therapeutic use*
chemical_list: D013256:Steroids; C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A