title: Intercellular adhesion molecule, plasma adiponectin and albuminuria in type 2 diabetic patients.
abstract: OBJECTIVE
  Our study addressed the influence of early inflammatory stages of diabetic kidney disease: leukocyte adhesion and monocyte activation (as assessed by intercellular leukocyte adhesion molecule-ICAM-1 and monocyte chemoatractant protein-MCP-1) on the degree of albuminuria. Plasma levels of adiponectin, a possible anti-inflammatory counteracting mechanism, were also studied in correlation to the above-mentioned cytokines.
  
  
  METHODS
  79 consecutive type 2 diabetic outpatients and 46 controls were included. Routine laboratory analysis, urinary albumin to creatinine ratio (uACR), plasma adiponectin, plasma ICAM-1 and urinary MPC-1 were assessed.
  
  
  RESULTS
  In multiple regression ICAM-1 (p=0.004) and adiponectin (p=0.04) were the main determinants of uACR. Plasma adiponectin positively correlated to ICAM-1 (p=0.03, r=0.24). In albuminuric patients (uACR ≥30 mg/g) plasma adiponectin was significantly higher compared to normoalbuminuric ones (uACR <30 mg/g). In albuminuric patients the main determinants of uACR were plasma ICAM-1 and adiponectin. In multiple regression ICAM-1 is the only one that retains statistical significance (p=0.02). Urinary MCP-1 did not correlate to uACR.
  
  
  CONCLUSIONS
  In our type 2 diabetic patients, plasma levels of ICAM-1 and adiponectin are predictive for albuminuria. Urinary MCP-1 does not correlated to uACR. Plasma adiponectin positively correlates to adhesion molecule ICAM-1 in our cohort.
authors.affiliation: University of Medicine and Pharmacy Iuliu Hatieganu Cluj Napoca, Department of Nephrology, Romania. alinalen@yahoo.com
authors.forename: Alina Ramona
authors.initials: AR
authors.lastname: Lenghel
authors.forename: Ina Maria
authors.initials: IM
authors.lastname: Kacso
authors.forename: Cosmina Ioana
authors.initials: CI
authors.lastname: Bondor
authors.forename: Crina
authors.initials: C
authors.lastname: Rusu
authors.forename: Rodica
authors.initials: R
authors.lastname: Rahaian
authors.forename: Mirela
authors.initials: M
authors.lastname: Gherman Caprioara
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D000369:Aged, 80 and over; D000419:Albuminuria / Q000097:blood* / Q000652:urine; D018932:Chemokine CCL2 / Q000097:blood; D003404:Creatinine / Q000097:blood / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000652:urine; D003928:Diabetic Nephropathies / Q000097:blood* / Q000652:urine; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000652:urine; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood* / Q000652:urine; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged
chemical_list: D052242:Adiponectin; D018932:Chemokine CCL2; D018799:Intercellular Adhesion Molecule-1; D003404:Creatinine