title: Gender differences in age-related changes in left and right ventricular geometries and functions. Echocardiography of a healthy subject group.
abstract: BACKGROUND
  The purpose of the present study was to investigate gender differences in age-related changes of left ventricular (LV) and right ventricular (RV) geometries and functions throughout the entire adult age range using the Japanese Normal Values for Echocardiographic Measurements Project (JAMP) study database.
  
  
  RESULTS
  Seven hundred healthy volunteers (aged 20-79 years) underwent 2-dimensional and Doppler echocardiography. The subjects were stratified into 6 different age groups and then stratified by gender in each age group. LV diastolic function was assessed from pulsed wave Doppler measurements of mitral early (E) and late (A) inflow velocities and tissue Doppler measurements of mitral early (e') and late (a') annular velocities. LV volume decreased and LV mass increased with age to a similar extent in both men and women. Furthermore, for subjects <50 years, women had significantly greater E, E/A ratio and e' than men, but these parameters were similar between genders in subjects >50 years. In addition, there was a significant interaction between age and gender that affected the differences in E, e' and E/e' among the groups (P<0.03, P<0.01, and P<0.03, respectively; ANOVA). There were no gender differences in age-related changes in RV parameters.
  
  
  CONCLUSIONS
  Gender differences were found in age-related changes in LV diastolic function in a healthy population. Gender differences should be considered for optimal diagnosis and management of cardiovascular disease.
authors.affiliation: Juntendo University, Tokyo, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Daimon
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Watanabe
authors.forename: Yukio
authors.initials: Y
authors.lastname: Abe
authors.forename: Kumiko
authors.initials: K
authors.lastname: Hirata
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hozumi
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Ishii
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ito
authors.forename: Katsuomi
authors.initials: K
authors.lastname: Iwakura
authors.forename: Chisato
authors.initials: C
authors.lastname: Izumi
authors.forename: Masunori
authors.initials: M
authors.lastname: Matsuzaki
authors.forename: Shinichi
authors.initials: S
authors.lastname: Minagoe
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Abe
authors.forename: Kazuya
authors.initials: K
authors.lastname: Murata
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nakatani
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Negishi
authors.forename: Ken
authors.initials: K
authors.lastname: Yoshida
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Tanabe
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Tanaka
authors.forename: Kotaro
authors.initials: K
authors.lastname: Tokai
authors.forename: Junichi
authors.initials: J
authors.lastname: Yoshikawa
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology; D002318:Cardiovascular Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology; D015150:Echocardiography, Doppler; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012727:Sex Characteristics; D016277:Ventricular Function, Left / Q000502:physiology*; D016278:Ventricular Function, Right / Q000502:physiology*