title: Breast cancer susceptibility polymorphisms and endometrial cancer risk: a Collaborative Endometrial Cancer Study.
abstract: Recent large--scale association studies, both of genome-wide and candidate gene design, have revealed several single-nucleotide polymorphisms (SNPs) which are significantly associated with risk of developing breast cancer. As both breast and endometrial cancers are considered to be hormonally driven and share multiple risk factors, we investigated whether breast cancer risk alleles are also associated with endometrial cancer risk. We genotyped nine breast cancer risk SNPs in up to 4188 endometrial cases and 11,928 controls, from between three and seven Caucasian populations. None of the tested SNPs showed significant evidence of association with risk of endometrial cancer.
authors.affiliation: Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK.
authors.forename: Catherine S
authors.initials: CS
authors.lastname: Healey
authors.forename: Shahana
authors.initials: S
authors.lastname: Ahmed
authors.forename: Tracy A
authors.initials: TA
authors.lastname: O'Mara
authors.forename: Kaltin
authors.initials: K
authors.lastname: Ferguson
authors.forename: Diether
authors.initials: D
authors.lastname: Lambrechts
authors.forename: Diego A
authors.initials: DA
authors.lastname: Garcia-Dios
authors.forename: Ignace
authors.initials: I
authors.lastname: Vergote
authors.forename: Frederic
authors.initials: F
authors.lastname: Amant
authors.forename: Kimberley
authors.initials: K
authors.lastname: Howarth
authors.forename: Maggie
authors.initials: M
authors.lastname: Gorman
authors.forename: Shirley
authors.initials: S
authors.lastname: Hodgson
authors.forename: Ian
authors.initials: I
authors.lastname: Tomlinson
authors.forename: Hannah P
authors.initials: HP
authors.lastname: Yang
authors.forename: Jolanta
authors.initials: J
authors.lastname: Lissowska
authors.forename: Louise A
authors.initials: LA
authors.lastname: Brinton
authors.forename: Stephen
authors.initials: S
authors.lastname: Chanock
authors.forename: Montserrat
authors.initials: M
authors.lastname: Garcia-Closas
authors.forename: Per
authors.initials: P
authors.lastname: Hall
authors.forename: Jianjun
authors.initials: J
authors.lastname: Liu
authors.forename: Mitul
authors.initials: M
authors.lastname: Shah
authors.forename: Paul D P
authors.initials: PD
authors.lastname: Pharoah
authors.forename: Deborah J
authors.initials: DJ
authors.lastname: Thompson
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Rebbeck
authors.forename: Brian L
authors.initials: BL
authors.lastname: Strom
authors.forename: Alison M
authors.initials: AM
authors.lastname: Dunning
authors.forename: Douglas F
authors.initials: DF
authors.lastname: Easton
authors.forename: Amanda B
authors.initials: AB
authors.lastname: Spurdle
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D016889:Endometrial Neoplasms / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult