title: Clinical response to Auron Misheil Therapy in a man with advanced multifocal hepatocellular carcinoma: A case report.
abstract: BACKGROUND
  Auron Misheil Therapy was developed based on similarities between carcinogenesis and inflammation. Auron Misheil Therapy is a combination of natural and synthetic compounds, including anti-inflammatory drugs and insulin, expected to exhibit synergistic effects.
  
  
  METHODS
  Here, we report the case of a 78-year-old Caucasian male patient who presented with multifocal hepatocellular carcinoma and chronic hepatitis C virus infection. Over a four-year period our patient was treated with radiofrequency ablation and transarterial chemoembolization. After these treatments there was tumor progression, with new hyperperfused lesions without evidence of extrahepatic tumor involvement. Our patient refused sorafenib therapy. Therefore, he received twice daily intramuscular injections of Auron Misheil Therapy on an outpatient basis for two months. Partial remission of the hepatic lesions was observed eight weeks after the start of treatment, and confirmed four weeks later. Unfortunately, at that time our patient refused therapy due to dizziness. During follow-up two target lesions remained stable, but one lesion increased in size. At the latest follow-up, one year later, there was still tumor control.
  
  
  CONCLUSIONS
  While the mechanisms underlying the antitumor effects of Auron Misheil Therapy are not fully understood, stable disease and remissions have been observed in different types of tumors, including hepatocellular carcinoma.
authors.affiliation: Department of Hematology and Oncology, University Medical Center Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany. juergen.scheele@uniklinik-freiburg.de.
authors.forename: Jürgen S
authors.initials: JS
authors.lastname: Scheele
authors.forename: Jan
authors.initials: J
authors.lastname: Harder
authors.forename: Zoran
authors.initials: Z
authors.lastname: Stankovic
authors.forename: Daniel
authors.initials: D
authors.lastname: Räpple
authors.forename: Annette
authors.initials: A
authors.lastname: Dorn
authors.forename: Hans C
authors.initials: HC
authors.lastname: Spangenberg
authors.forename: Hubert E
authors.initials: HE
authors.lastname: Blum