title: Obtain osteoarthritis related molecular signature genes through regulation             network.
abstract: Osteoarthritis (OA), also known as degenerative joint disease or osteoarthrosis,             is the most common form of arthritis. OA occurs when cartilage in the joints wears             down over time. We used the GSE1919 series to identify potential genes that correlated             to OA. The aim of our study was to obtain a molecular signature of OA through             the regulation network based on differentially expressed genes. From the result             of regulation network construction in OA, a number of transcription factors (TFs)             and pathways closely related to OA were linked by our method. Peroxisome proliferator-activated             receptor γ also arises as hub nodes in our transcriptome network and certain TFs             containing CEBPD, EGR2 and ETS2 were shown to be related to OA by a previous study.
authors.affiliation: Department of Spinal Surgery, The Second Xiangya Hospital of Central South University, Hunan 410011, PR China.
authors.forename: Yawei
authors.initials: Y
authors.lastname: Li
authors.forename: Bing
authors.initials: B
authors.lastname: Wang
authors.forename: Guohua
authors.initials: G
authors.lastname: Lv
authors.forename: Guangzhong
authors.initials: G
authors.lastname: Xiong
authors.forename: Wei Dong
authors.initials: WD
authors.lastname: Liu
authors.forename: Lei
authors.initials: L
authors.lastname: Li
mesh_terms: D030541:Databases, Genetic; D053263:Gene Regulatory Networks; D006801:Humans; D010003:Osteoarthritis / Q000235:genetics*; D047495:PPAR gamma / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D059467:Transcriptome
chemical_list: D047495:PPAR gamma; D014157:Transcription Factors