title: Palladium-catalyzed coupling of arene C-H bonds with methyl- and arylboron reagents assisted by the removable 2-pyridylsulfinyl group.
abstract: The Pd(II)-catalyzed direct coupling of arene C-H bonds with organoboron reagents assisted by the 2-pyridylsulfinyl group is reported. Methylboronic acid and arylboronic acid neopentyl esters proved to be efficient coupling partners, furnishing methylated arenes and biaryl products in moderate to good yields. The 2-pyridylsulfinyl group can be easily removed to provide the free biaryls. The essential role of the 2-pyridyl unit in stabilizing the cyclopalladation complex was demonstrated by X-ray diffraction analysis of the palladacycle intermediate.
authors.affiliation: Departamento de Quı́mica Orgánica, Universidad Autónoma de Madrid, Facultad de Ciencias, Cantoblanco, 28049 Madrid, Spain.
authors.forename: José A
authors.initials: JA
authors.lastname: Romero-Revilla
authors.forename: Alfonso
authors.initials: A
authors.lastname: García-Rubia
authors.forename: Ramón
authors.initials: R
authors.lastname: Goméz Arrayás
authors.forename: M Ángeles
authors.initials: MÁ
authors.lastname: Fernández-Ibáñez
authors.forename: Juan C
authors.initials: JC
authors.lastname: Carretero