title: [Role of IL-12P40 and IL-10 in progression of colorectal cancer].
abstract: The aim of study was to investigate the association between serum levels of IL-12p40 and IL-10 and progression of the colorectal cancer (CRC). Be observed an association between severity of CRC and serum levels of investigated cytokines. IL-12p40 was in the highest level in stage-I (423.6 +/- 224.7 pg/ml) compared to more severe stages. In the opposite direction were the data for immunosuppressive cytokine, IL-10. Patients with stage-IV had the highest level of IL-10 (36.02 +/- 9.5 pg/ml). On the basis of our results we could conclude that IL-12p40 and IL-10 serum levels were associated with tumour progression. More severe stages of CRC are characterized by low IL-12p40 and high IL-10 serum levels.
authors.forename: N
authors.initials: N
authors.lastname: Stanilov
authors.forename: L
authors.initials: L
authors.lastname: Miteva
authors.forename: N
authors.initials: N
authors.lastname: Stankova
authors.forename: J
authors.initials: J
authors.lastname: Jovchev
authors.forename: T
authors.initials: T
authors.lastname: Deliyski
authors.forename: S
authors.initials: S
authors.lastname: Stanilova
mesh_terms: D000368:Aged; D015179:Colorectal Neoplasms / Q000097:blood* / Q000473:pathology*; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D053762:Interleukin-12 Subunit p40 / Q000097:blood*; D008297:Male; D009367:Neoplasm Staging
chemical_list: D053762:Interleukin-12 Subunit p40; D016753:Interleukin-10