title: Synthesis of "two-story" calix[6]aza-cryptands.
abstract: The first four members of a new family of C(3v)-symmetrical "two-story" calix[6]aza-cryptands have been synthesized. These large funnel shaped aza-ligands are formed through introduction of three aromatic arms as spacers onto the small rim of a calix[6]arene and subsequently capped with the tripodal aza caps tacn [1,3,5-triazacyclononane] or tren [tris(aminoethyl)amine]. A key feature for an efficient final 1:1 macrocyclization appears to be an adequate geometrical fit between the extended calixarene scaffold and the aza caps.
authors.affiliation: Laboratoire de Chimie et de Biochimie pharmacologiques et toxicologiques, Université Paris Descartes, Sorbonne Paris Cité, CNRS UMR 860, 45, rue des Saints Pères, 75006 Paris, France.
authors.forename: Xianshun
authors.initials: X
authors.lastname: Zeng
authors.forename: Claudia
authors.initials: C
authors.lastname: Bornholdt
authors.forename: Diana
authors.initials: D
authors.lastname: Over
authors.forename: Olivia
authors.initials: O
authors.lastname: Reinaud
mesh_terms: D001372:Aza Compounds / Q000737:chemistry*; D047250:Calixarenes / Q000138:chemical synthesis* / Q000737:chemistry; D043844:Crown Ethers / Q000138:chemical synthesis* / Q000737:chemistry; D008024:Ligands; D015394:Molecular Structure
chemical_list: D001372:Aza Compounds; D043844:Crown Ethers; D008024:Ligands; D047250:Calixarenes