title: Susceptibility to exudative age-related macular degeneration and three genetic polymorphisms of glutathione S-transferase Z1 (GSTZ1).
abstract: OBJECTIVE
  To investigate whether genetic polymorphisms of GSTZ1 contribute to the development of exudative age-related macular degeneration (AMD).
  
  
  METHODS
  The present case-control study consisted of 112 patients (44 female, 68 male) with exudative AMD and 112 sex frequency-matched healthy controls were randomly selected from unrelated volunteers in the same clinic. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism-based method.
  
  
  RESULTS
  There was no significant association between study polymorphisms and susceptibility to exudative AMD. Considering the significant difference in age distribution between cases and controls, age was used as a covariate in further analysis. After odds ratio adjustment for age, the same results were observed. The study polymorphisms showed linkage disequilibrium. Analysis revealed that there was no difference between cases and controls for the prevalence of the haplotypes of GSTZ1.
  
  
  CONCLUSIONS
  Our study did not support any association between susceptibility to exudative AMD and polymorphisms of GSTZ1.
authors.affiliation: Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran.
authors.forename: Hasan
authors.initials: H
authors.lastname: Othman
authors.forename: Iraj
authors.initials: I
authors.lastname: Saadat
authors.forename: Majid
authors.initials: M
authors.lastname: Farvardin-Jahromi
authors.forename: Mostafa
authors.initials: M
authors.lastname: Saadat
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005122:Exudates and Transudates; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008268:Macular Degeneration / Q000201:enzymology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D014792:Visual Acuity
chemical_list: C407705:GSTZ1 protein, human; D005982:Glutathione Transferase