title: Cutaneous reactions to non-steroidal anti-inflammatory drugs.
abstract: We retrospectively reviewed the records of 195 patients with suspected cutaneous reactions from NSAIDs. Two hundred and six different non-steroidal anti-inflammatory drugs (NSAIDs) were suspected of causing cutaneous reactions, and the most frequent suspected causative NSAID was ibuprofen (25.7%). Angioedema and/or urticaria were the most frequent cutaneous reactions (54.4%), and the foremost suspected causative drug for these reactions was ibuprofen. The second most frequently found cutaneous reaction was maculopapular eruption (26.2%), and celecoxib was the most commonly suspected causative NSAID for it. The primary suspected NSAIDs causing fixed drug eruption were in enolic acid group. Furthermore, drug hypersensitivity syndrome was diagnosed in five patients, and Stevens-Johnson syndrome and toxic epidermal necrolysis were detected in five patients.
authors.affiliation: Department of Dermatology, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Pranee
authors.initials: P
authors.lastname: Kasemsarn
authors.forename: Kanokvalai
authors.initials: K
authors.lastname: Kulthanan
authors.forename: Papapit
authors.initials: P
authors.lastname: Tuchinda
authors.forename: Naruemon
authors.initials: N
authors.lastname: Dhana
authors.forename: Kowit
authors.initials: K
authors.lastname: Jongjarearnprasert
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000799:Angioedema / Q000139:chemically induced; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000068579:Celecoxib; D003875:Drug Eruptions / Q000209:etiology*; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D011720:Pyrazoles / Q000009:adverse effects; D012189:Retrospective Studies; D013449:Sulfonamides / Q000009:adverse effects; D014581:Urticaria / Q000139:chemically induced; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011720:Pyrazoles; D013449:Sulfonamides; D000068579:Celecoxib; D007052:Ibuprofen