title: Antimicrobial antioxidant daucane sesquiterpenes from Ferula hermonis Boiss.
abstract: Seventeen daucane sesquiterpenoid esters, including a new one (4), were isolated from the root of Ferula hermonis Boiss. The structures of the isolated compounds were elucidated on the basis of spectroscopic evidence and correlated with known compounds. The relative stereochemistry of the new compound was determined using 2D NOESY and the most stable and the lowest energy conformation was determined using molecular modelling. The antimicrobial activity was evaluated by determination of MIC using the broth microdilution method against six bacterial strains and one fungal strain (Pseudomonas aeruginosa PAO1, Escherichia coli, Bacillus subtilis ATCC6633, Mycobacterium bovis BCG Pasteur, Mycobacterium tuberculosis H37Rv, Staphylococcus aureus ATCC6538 and Candida albicans SC5314). There was a significant indication that compounds 15, 16, 17 demonstrated potent activity against Gram +ve (S. aureus, B. subtilis), as well as Mycobacterium strains M. bovis BCG and M. tuberculosis H37Rv. None of the isolated compounds exhibited a significant antifungal activity. In the antioxidant study using the DPPH assay method, the highest radical scavenging activity was observed for compounds 15, 16, 17.
authors.affiliation: Pharmacognosy Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt. Zedanibraheim59@hotmail.com
authors.forename: Zedan Zeid
authors.initials: ZZ
authors.lastname: Ibraheim
authors.forename: Wael M
authors.initials: WM
authors.lastname: Abdel-Mageed
authors.forename: Huanqin
authors.initials: H
authors.lastname: Dai
authors.forename: Hui
authors.initials: H
authors.lastname: Guo
authors.forename: Lixin
authors.initials: L
authors.lastname: Zhang
authors.forename: Marcel
authors.initials: M
authors.lastname: Jaspars
mesh_terms: D000890:Anti-Infective Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001565:Benzoates / Q000302:isolation & purification / Q000494:pharmacology; D001643:Bridged Bicyclo Compounds / Q000302:isolation & purification / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003508:Cycloheptanes / Q000302:isolation & purification / Q000494:pharmacology; D004357:Drug Synergism; D005309:Ferula / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000302:isolation & purification* / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D018517:Plant Roots / Q000737:chemistry; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D014641:Vanillic Acid / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D001565:Benzoates; D001643:Bridged Bicyclo Compounds; D003508:Cycloheptanes; D016166:Free Radical Scavengers; D012717:Sesquiterpenes; C493118:jaeschkeanadiol; C507392:teferin; C111068:4-oxy-6-(4-oxybezoyloxy)dauc-8,9-en; D014641:Vanillic Acid