title: The utility of naphthyl-keratin adducts as biomarkers for jet-fuel exposure.
abstract: We investigated the association between biomarkers of dermal exposure, naphthyl-keratin adducts (NKA), and urine naphthalene biomarker levels in 105 workers routinely exposed to jet-fuel. A moderate correlation was observed between NKA and urine naphthalene levels (p = 0.061). The NKA, post-exposure breath naphthalene, and male gender were associated with an increase, while CYP2E1*6 DD and GSTT1-plus (++/+-) genotypes were associated with a decrease in urine naphthalene level (p < 0.0001). The NKA show great promise as biomarkers for dermal exposure to naphthalene. Further studies are warranted to characterize the relationship between NKA, other exposure biomarkers, and/or biomarkers of biological effects due to naphthalene and/or PAH exposure.
authors.affiliation: Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, USA.
authors.forename: Juei-Chuan C
authors.initials: JC
authors.lastname: Kang-Sickel
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Butler
authors.forename: Lynn
authors.initials: L
authors.lastname: Frame
authors.forename: Berrin
authors.initials: B
authors.lastname: Serdar
authors.forename: Yi-Chun E
authors.initials: YC
authors.lastname: Chao
authors.forename: Peter
authors.initials: P
authors.lastname: Egeghy
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Rappaport
authors.forename: Christine A
authors.initials: CA
authors.lastname: Toennis
authors.forename: Wang
authors.initials: W
authors.lastname: Li
authors.forename: Tatyana
authors.initials: T
authors.lastname: Borisova
authors.forename: John E
authors.initials: JE
authors.lastname: French
authors.forename: Leena A
authors.initials: LA
authors.lastname: Nylander-French
mesh_terms: D000293:Adolescent; D000328:Adult; D000395:Air Pollutants, Occupational / Q000032:analysis / Q000506:poisoning; D000401:Aircraft; D015415:Biomarkers / Q000032:analysis* / Q000737:chemistry; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D006838:Hydrocarbons / Q000032:analysis* / Q000506:poisoning; D007633:Keratins / Q000032:analysis* / Q000737:chemistry; D008297:Male; D008889:Military Personnel; D009281:Naphthalenes / Q000032:analysis* / Q000737:chemistry / Q000652:urine; D016273:Occupational Exposure / Q000009:adverse effects / Q000032:analysis*; D011084:Polycyclic Aromatic Hydrocarbons / Q000506:poisoning; D012044:Regression Analysis; D012867:Skin / Q000378:metabolism; D013723:Teratogens / Q000032:analysis; D055815:Young Adult
chemical_list: D000395:Air Pollutants, Occupational; D015415:Biomarkers; D006838:Hydrocarbons; C098607:JP8 aviation fuel; D009281:Naphthalenes; D011084:Polycyclic Aromatic Hydrocarbons; D013723:Teratogens; C031721:naphthalene; D007633:Keratins; D019392:Cytochrome P-450 CYP2E1; C413545:glutathione S-transferase T1; D005982:Glutathione Transferase