title: Synthetic analogues of mycobacterial arabinogalactan linkage-disaccharide part II: synthesis and preliminary screening of lipophilic O-alkyl glycosides.
abstract: Lipophilic analogues of the linkage-disaccharide found in the mycobacterial cell wall were synthesized and the synthetic analogues when biologically evaluated showed promising antimycobacterial property with MIC value in the range 3.13-12.50 μg/mL against Mycobacterium tuberculosis H(37)Rv.
authors.affiliation: Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, S.A.S. Nagar, Punjab 160062, India.
authors.forename: G
authors.initials: G
authors.lastname: Mugunthan
authors.forename: Dharmarajan
authors.initials: D
authors.lastname: Sriram
authors.forename: Perumal
authors.initials: P
authors.lastname: Yogeeswari
authors.forename: K P Ravindranathan
authors.initials: KP
authors.lastname: Kartha
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002473:Cell Wall / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D004187:Disaccharides / Q000138:chemical synthesis* / Q000494:pharmacology; D005685:Galactans / Q000737:chemistry*; D006027:Glycosides / Q000138:chemical synthesis* / Q000494:pharmacology; D006031:Glycosylation; D057927:Hydrophobic and Hydrophilic Interactions; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000737:chemistry / Q000187:drug effects
chemical_list: D000995:Antitubercular Agents; D004187:Disaccharides; D005685:Galactans; D006027:Glycosides; C005653:arabinogalactan