title: Macrophage activation governs schistosomiasis-induced inflammation and fibrosis.
abstract: Macrophages regulate the initiation, maintenance, and resolution of chronic inflammatory responses and their function depends on their activation status. Studies in mice infected with the helminth parasite Schistosoma mansoni have been particularly helpful in defining the in vivo function of classically and alternatively activated macrophages (AAMϕs). These studies have shown that AAMϕs protect mice from acute and chronic S. mansoni infection through distinct mechanisms, which are discussed in this Viewpoint.
authors.affiliation: Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Luke
authors.initials: L
authors.lastname: Barron
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Wynn
mesh_terms: D000208:Acute Disease; D000818:Animals; D002908:Chronic Disease; D006801:Humans; D007249:Inflammation; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology* / Q000382:microbiology; D051379:Mice; D012547:Schistosoma / Q000276:immunology*; D012552:Schistosomiasis / Q000276:immunology*