title: Long-term outcomes in octogenarians following aortic valve replacement.
abstract: BACKGROUND
  The aging of the population has resulted in an increasing number of elderly patients undergoing cardiac operations. We reviewed our experience in patients over the age of 80 undergoing primary aortic valve replacement (AVR) with or without CABG.
  
  
  METHODS
  Between 2000 and 2008, 345 patients (226 male) ≥80 years underwent primary AVR in our unit. The notes of these patients were retrospectively reviewed and follow-up information was obtained from their general practitioners. They had a mean age of 82.9 ± 2.3 years and a median logistic EuroSCORE of 13.4 (IQR 9.4, 19.1). Isolated AVR was performed in 161 patients (45.5%), and 184 (51.6%) patients underwent combined AVR and CABG. A quality of life questionnaire was sent to all survivors.
  
  
  RESULTS
  Hospital mortality occurred in 17 patients (4.9%), which was significantly lower than the mortality predicted by logistic EuroSCORE (16.2%, p < 0.01). Hospital mortality was comparable between patients undergoing isolated AVR and those undergoing additional CABG (4.3% vs. 5.4%, respectively). Actuarial survival at one and five years was 90.1 ± 1.6% and 77.2 ± 2.9%, respectively. There was a 62% response on the questionnaire showing 70% of the patients were NYHA I and 83.7% were satisfied with the operation outcome.
  
  
  CONCLUSIONS
  AVR can be undertaken with excellent results in octogenarians and the current risk is significantly lower than what is predicted with conventional risk-scoring systems. Patients with advanced age should not necessarily be excluded from being candidates for AVR.
authors.affiliation: Wessex Cardiac Centre, Southampton University Hospital, Tremona Road, Southampton SO16 6YD, United Kingdom. nicnik1977@yahoo.com
authors.forename: Nicolas
authors.initials: N
authors.lastname: Nikolaidis
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Pousios
authors.forename: Marcus P
authors.initials: MP
authors.lastname: Haw
authors.forename: Markku
authors.initials: M
authors.lastname: Kaarne
authors.forename: Clifford W
authors.initials: CW
authors.lastname: Barlow
authors.forename: Steve A
authors.initials: SA
authors.lastname: Livesey
authors.forename: Geoff M
authors.initials: GM
authors.lastname: Tsang
authors.forename: Sunil K
authors.initials: SK
authors.lastname: Ohri
mesh_terms: D000367:Age Factors; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006349:Heart Valve Diseases / Q000401:mortality / Q000601:surgery*; D019918:Heart Valve Prosthesis Implantation / Q000379:methods* / Q000401:mortality; D017052:Hospital Mortality / Q000639:trends; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate / Q000639:trends; D013997:Time Factors; D016896:Treatment Outcome; D006113:United Kingdom / Q000453:epidemiology