title: Synthesis and in-vivo evaluation of carbonyl-amide linkage based new benzimidazole derivatives.
abstract: In search of pharmacologically active potent compounds, a series of carbonyl-amide linkage based new benzimidazole derivatives were synthesized from acid, aldehydes and isocyanide at ambient temperature via Passerini reaction. All the compounds synthesized were screened for their potential anti-inflammatory, antidiabetic and anticonvulsant properties. The results revealed that compounds 2i and 2j were found to be the most potent anti-inflammatory agents, while compounds 2a, 2c, 2e, 2f, 2i and 2j showed increased antidiabetic activity than the reference drugs and 2a, 2g, 2h, 2i and 2j were found to be the main structural requirement for maintaining anticonvulsant activity.
authors.affiliation: P.G. Department of Studies in Chemistry, Karnatak University, Dharwad, India.
authors.forename: Irfan N
authors.initials: IN
authors.lastname: Shaikh
authors.forename: Kallappa M
authors.initials: KM
authors.lastname: Hosamani
authors.forename: Harisha R
authors.initials: HR
authors.lastname: Seetharamareddy
authors.forename: Mallinath H
authors.initials: MH
authors.lastname: Hugar
mesh_terms: D000577:Amides / Q000737:chemistry*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D001786:Blood Glucose / Q000032:analysis; D002244:Carbon / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy; D015195:Drug Design; D004487:Edema / Q000188:drug therapy; D005260:Female; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D008297:Male; D051381:Rats; D012640:Seizures / Q000188:drug therapy; D023382:Toxicity Tests, Acute
chemical_list: D000577:Amides; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants; D001562:Benzimidazoles; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D002244:Carbon