title: Neonatal diethylstilbestrol exposure disrupts female reproductive tract structure/function via both direct and indirect mechanisms in the hamster.
abstract: We assessed neonatal diethylstilbestrol (DES)-induced disruption at various endocrine levels in the hamster. In particular, we used organ transplantation into the hamster cheek pouch to determine whether abnormalities observed in the post-pubertal ovary are due to: (a) a direct (early) mechanism or (b) an indirect (late) mechanism that involves altered development and function of the hypothalamus and/or pituitary. Of the various disruption endpoints and attributes assessed: (1) some were consistent with the direct mechanism (altered uterine and cervical dimensions/organization, ovarian polyovular follicles, vaginal hypospadius, endometrial hyperplasia/dysplasia); (2) some were consistent with the indirect mechanism (ovarian/oviductal salpingitis, cystic ovarian follicles); (3) some were consistent with a combination of the direct and indirect mechanisms (altered endocrine status); and (4) the mechanism(s) for one (lack of corpora lutea) was uncertain. This study also generated some surprising observations regarding vaginal estrous assessments as a means to monitor periodicity of ovarian function in the hamster.
authors.affiliation: Department of Biological Sciences, Wichita State University, 1845 Fairmount, Wichita, KS 67260-0026, United States.
authors.forename: Imala D
authors.initials: ID
authors.lastname: Alwis
authors.forename: Dulce M
authors.initials: DM
authors.lastname: Maroni
authors.forename: Isabel R
authors.initials: IR
authors.lastname: Hendry
authors.forename: Shyamal K
authors.initials: SK
authors.lastname: Roy
authors.forename: Jeffrey V
authors.initials: JV
authors.lastname: May
authors.forename: Wendell W
authors.initials: WW
authors.lastname: Leavitt
authors.forename: William J
authors.initials: WJ
authors.lastname: Hendry
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002584:Cervix Uteri / Q000033:anatomy & histology; D006224:Cricetinae; D004054:Diethylstilbestrol / Q000633:toxicity*; D004968:Estrogens, Non-Steroidal / Q000633:toxicity*; D030762:Estrous Cycle; D005187:Fallopian Tubes / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology; D005260:Female; D005836:Genitalia, Female / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology; D006728:Hormones / Q000097:blood; D007031:Hypothalamus / Q000502:physiology; D008647:Mesocricetus; D010052:Ovariectomy; D010053:Ovary / Q000033:anatomy & histology / Q000502:physiology / Q000637:transplantation; D010902:Pituitary Gland / Q000502:physiology; D011247:Pregnancy; D012741:Sexual Maturation; D014599:Uterus / Q000033:anatomy & histology; D014621:Vagina / Q000502:physiology
chemical_list: D004968:Estrogens, Non-Steroidal; D006728:Hormones; D004054:Diethylstilbestrol