title: Monitoring the fidelity of mitotic chromosome segregation by the spindle assembly checkpoint.
abstract: Accurate chromosome segregation relies on activity of the spindle assembly checkpoint, a surveillance mechanism that prevents premature anaphase onset until all chromosomes are properly attached to the mitotic spindle apparatus and aligned at the metaphase plate. Defects in this mechanism contribute to chromosome instability and aneuploidy, a hallmark of malignant cells. Here, we review the molecular mechanisms of activation and silencing of the spindle assembly checkpoint and its relationship to tumourigenesis.
authors.affiliation: Health Sciences Research Center, Superior Institute of Health Sciences - North, CESPU, Gandra PRD, Portugal.
authors.forename: P
authors.initials: P
authors.lastname: Silva
authors.forename: J
authors.initials: J
authors.lastname: Barbosa
authors.forename: A V
authors.initials: AV
authors.lastname: Nascimento
authors.forename: J
authors.initials: J
authors.lastname: Faria
authors.forename: R
authors.initials: R
authors.lastname: Reis
authors.forename: H
authors.initials: H
authors.lastname: Bousbaa
mesh_terms: D000705:Anaphase / Q000235:genetics / Q000502:physiology; D000818:Animals; D020090:Chromosome Segregation / Q000235:genetics* / Q000502:physiology*; D018816:Genes, cdc; D006801:Humans; D018386:Kinetochores / Q000502:physiology; D008870:Microtubules / Q000235:genetics / Q000502:physiology; D008938:Mitosis / Q000235:genetics* / Q000502:physiology*; D008954:Models, Biological; D009369:Neoplasms / Q000209:etiology / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction; D008941:Spindle Apparatus / Q000235:genetics / Q000502:physiology*