title: Lower urinary tract symptoms have negative associations with glomerular filtration rate irrespective of prostate volume in Korean men.
abstract: OBJECTIVE
  To understand the relationship between lower urinary tract symptoms (LUTS) and renal function by prostate volume (PV) in Korean men. LUTS can be related to early renal dysfunction, irrespective of bladder outlet obstructive lesions, few studies have been conducted.
  
  
  METHODS
  We conducted a cross-sectional survey of 3713 men, aged≥40 years, who received routine comprehensive health evaluations, including transrectal ultrasonography and the International Prostate Symptom Score questionnaire. We used the estimated glomerular filtration rate (GFR) for the assessment of renal function and the IPSS for LUTS severity. We compared LUTS and GFR using multivariate regression analysis after adjusting for age and/or PV.
  
  
  RESULTS
  An increasing severity of LUTS, especially voiding LUTS, was associated with a decreasing GFR in the older age group (≥55 years). In a stratified analysis by PV of 30 cm3, voiding LUTS showed a negative association with GFR, irrespective of the PV (P for trend<.01 and P for trend<.02), but total LUTS did so only in the small PV group.
  
  
  CONCLUSIONS
  In men without known urinary tract disease, LUTS and renal function had a negative association, especially in older men with a normal PV. Although the underlying mechanism is uncertain, physicians who treat patients with moderate or severe LUTS should monitor renal function, even in patients with a normal PV.
authors.affiliation: Department of Family Medicine, Sahmyook Medical Center, Seoul, South Korea.
authors.forename: Young-Min
authors.initials: YM
authors.lastname: Kwon
authors.forename: Belong
authors.initials: B
authors.lastname: Cho
authors.forename: Ki Young
authors.initials: KY
authors.lastname: Son
authors.forename: Ho-Chun
authors.initials: HC
authors.lastname: Choi
authors.forename: Seung-Guk
authors.initials: SG
authors.lastname: Park
authors.forename: Jin-Ho
authors.initials: JH
authors.lastname: Park
mesh_terms: D000328:Adult; D000367:Age Factors; D044466:Asian People / Q000706:statistics & numerical data*; D015331:Cohort Studies; D016001:Confidence Intervals; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D015994:Incidence; D059411:Lower Urinary Tract Symptoms / Q000175:diagnosis* / Q000453:epidemiology* / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011467:Prostate / Q000254:growth & development; D011470:Prostatic Hyperplasia / Q000175:diagnosis* / Q000453:epidemiology* / Q000208:ethnology; D012016:Reference Values; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index