title: Molecular biology of myelodysplastic syndromes.
abstract: Myelodysplastic syndromes (MDS) are a group of clonal hematopoetic disorders marked by ineffective hematopoiesis, peripheral cytopenias, and an increased risk of transformation to acute myeloid leukemia. Multiple processes govern hematopoietic progenitor proliferation and natural differentiation into mature myeloid elements. Molecular events that disrupt any of these processes have the potential to lead to ineffective hematopoiesis and an MDS phenotype. Recent advances in genomic analysis have identified a number of new genes that may be involved. The molecular description of MDS will lead to better understanding, classification, and treatment of this disease.
authors.affiliation: Human Oncology and Pathogenesis Program and Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, NY 10065, USA.
authors.forename: Alan H
authors.initials: AH
authors.lastname: Shih
authors.forename: Ross L
authors.initials: RL
authors.lastname: Levine
mesh_terms: D044127:Epigenesis, Genetic; D006801:Humans; D058990:Molecular Targeted Therapy; D009190:Myelodysplastic Syndromes / Q000235:genetics* / Q000503:physiopathology; D015398:Signal Transduction; D055153:Stem Cell Niche; D014157:Transcription Factors
chemical_list: D014157:Transcription Factors