title: On the lookout for precursor lesions: where does dry skin end and slight hand eczema begin?
abstract: BACKGROUND
  The prognosis of occupational hand eczema is strongly associated with its duration, severity, and the onset of treatment.
  
  
  OBJECTIVE
  The study was aimed at characterizing skin eruptions that might be potential precursors of occupational hand eczema, their pattern, and typical sites in a population at moderate risk of hand eczema.
  
  
  METHODS
  Eight hundred German male metal workers took part in a structured interview focused on their medical history combined with a dermatological examination of their hands, by use of the quantitative Hand Eczema Score for Occupational Screenings, with follow-up 1 year later.
  
  
  RESULTS
  The most frequent lesions were erythema (91.8%), lichenification (98.8%), crusting (70%), and scaling (35%); all other lesions were relatively rare (15%). The distribution of lesions remained stable between baseline and follow-up. The areas most affected were knuckles, palms, and finger shafts (excluding tips). Interdigital regions were uncommonly affected in this sample.
  
  
  CONCLUSIONS
  Erythema, lichenification, and crusting, indicating constant skin 'strain', can be regarded as precursor lesions for slight hand eczema, and should be monitored quantitatively. As other occupations, for example hairdressing, have different predilection sites, it can be concluded that the pattern of occupational hand eczema is strongly influenced by the distinct strain profile of an occupation.
authors.affiliation: Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen-Nuremberg, Schillerstr. 25 + 29, D-91054 Erlangen, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Baumeister
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Uter
authors.forename: Wobbeke
authors.initials: W
authors.lastname: Weistenhöfer
authors.forename: Hans
authors.initials: H
authors.lastname: Drexler
authors.forename: Birgitta
authors.initials: B
authors.lastname: Kütting
mesh_terms: D000293:Adolescent; D000328:Adult; D009783:Dermatitis, Occupational / Q000453:epidemiology / Q000473:pathology*; D004485:Eczema / Q000453:epidemiology / Q000473:pathology*; D005500:Follow-Up Studies; D005858:Germany / Q000453:epidemiology; D006229:Hand Dermatoses / Q000453:epidemiology / Q000473:pathology*; D006801:Humans; D008297:Male; D008669:Metallurgy; D008875:Middle Aged; D036301:Qualitative Research; D018570:Risk Assessment; D012720:Severity of Illness Index; D055815:Young Adult