title: Asymmetric multi-component reactions: convenient access to acyclic stereocenters and functionalized cyclopentenoids.
abstract: Asymmetric multi-component reactions of optically active phenyl dihydrofuran, keto ester or N-tosyl imino ester, and allylsilane provided functionalized phenyl tetrahydrofurans with multiple stereogenic centers diastereoselectively. Cleavage of the resulting substituted tetrahydrofurans readily provided acyclic derivatives with three contiguous asymmetric centers via an acyloxycarbenium ion intermediate. Ring closing olefin metathesis, using Grubbs catalyst, afforded functionalized cyclopentene derivatives in optically active form. A one pot tandem tetrahydrofuran ring cleavage followed by ring closing olefin metathesis also provided functionalized cyclopentenes in good yield.
authors.affiliation: Department of Chemistry and Medicinal Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA.
authors.forename: Arun K
authors.initials: AK
authors.lastname: Ghosh
authors.forename: Sarang S
authors.initials: SS
authors.lastname: Kulkarni
authors.forename: Chun-Xiao
authors.initials: CX
authors.lastname: Xu
authors.forename: Khriesto
authors.initials: K
authors.lastname: Shurrush