title: Extensively spreading intraepithelial bile duct carcinoma causing multiple bile duct strictures: report of three cases.
abstract: Extensive intraepithelial spread of bile duct carcinoma is a common feature, seen in approximately 18% of all cases. However, this spread is rarely accompanied by bile duct strictures. We herein describe three cases of bile duct carcinoma with multiple bile duct strictures due to extensive intraepithelial spread. In all three cases, the spread of intraepithelial cancer extended into the epithelium of the peribiliary glands along the intrahepatic bile ducts with marked fibrosis on histopathological examination. It is speculated that peribiliary gland involvement by superficially spreading bile duct cancer and subsequent obstructive glandular inflammation with fibrosis might cause intrahepatic bile duct strictures even without interstitial cancer invasion.
authors.affiliation: Department of Surgical Oncology, Division of Surgery, Hokkaido University Graduate School of Medicine, N-15, W-17, Sapporo, 060-0815, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Tsuchikawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kondo
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hirano
authors.forename: Eiichi
authors.initials: E
authors.lastname: Tanaka
authors.forename: Kentaro
authors.initials: K
authors.lastname: Kato
authors.forename: Joe
authors.initials: J
authors.lastname: Matsumoto
authors.forename: Kanako C
authors.initials: KC
authors.lastname: Kubota
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Shichinohe
mesh_terms: D000368:Aged; D001650:Bile Duct Neoplasms / Q000150:complications*; D001653:Bile Ducts, Intrahepatic / Q000473:pathology*; D018281:Cholangiocarcinoma / Q000150:complications*; D002780:Cholestasis, Intrahepatic / Q000209:etiology*; D003251:Constriction, Pathologic; D006801:Humans; D008297:Male