title: Zinc monotherapy from time of diagnosis for young pediatric patients with presymptomatic Wilson disease.
abstract: In 4 young pediatric patients with presymptomatic Wilson disease, we found zinc monotherapy beginning at time of diagnosis to be safe and highly effective for follow-up intervals between 1 and 2 years. Such maintenance therapy with zinc can maintain urinary copper excretion between 1 and 3 μg · kg(-1) · day.
authors.affiliation: Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Japan.
authors.forename: Tatsuki
authors.initials: T
authors.lastname: Mizuochi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kimura
authors.forename: Norikazu
authors.initials: N
authors.lastname: Shimizu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nishiura
authors.forename: Masami
authors.initials: M
authors.lastname: Matsushita
authors.forename: Makoto
authors.initials: M
authors.lastname: Yoshino
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D058070:Asymptomatic Diseases / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D003300:Copper / Q000097:blood / Q000652:urine; D005260:Female; D005500:Follow-Up Studies; D006527:Hepatolenticular Degeneration / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D015032:Zinc / Q000627:therapeutic use*
chemical_list: D003300:Copper; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D015032:Zinc