title: Antiangiogenic effect of chamigrane endoperoxides from a Thai mangrove-derived fungus.
abstract: As part of our ongoing efforts to investigate natural products with potential for use as cancer treatments, we have recently disclosed the cytotoxicity of unique nor-chamigrane (1) and chamigrane (2, 3) endoperoxides from a Thai mangrove-derived fungus. Reinvestigation of this fungus in a large-scale fermentation led to the isolation of an additional new chamigrane endoperoxide (4) and one known analogue (5). Among these isolated metabolites, compound 3 (merulin C) exhibited potent antiangiogenic activity mainly by suppression of endothelial cell proliferation and migration in a dose-dependent manner, and its effect is mediated by reduction in the phosphorylation of Erk1/2. Merulin C also displayed promising activity in a rat aortic ring sprouting (ex vivo) and a mouse Matrigel (in vivo) assay.
authors.affiliation: Program in Biotechnology, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Supichar
authors.initials: S
authors.lastname: Chokpaiboon
authors.forename: Damrong
authors.initials: D
authors.lastname: Sommit
authors.forename: Taridaporn
authors.initials: T
authors.lastname: Bunyapaiboonsri
authors.forename: Kiminori
authors.initials: K
authors.lastname: Matsubara
authors.forename: Khanitha
authors.initials: K
authors.lastname: Pudhom
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000187:drug effects; D001487:Basidiomycota / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D029582:Meliaceae / Q000382:microbiology; D051379:Mice; D015394:Molecular Structure; D010545:Peroxides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018515:Plant Leaves / Q000382:microbiology; D051381:Rats; D013785:Thailand
chemical_list: D020533:Angiogenesis Inhibitors; D010545:Peroxides; C550061:merulin C