title: The involvement of NF-?B Transcription factor in asthma.
abstract: PubMed search was performed using the key words: NF-?B, nuclear factors, asthma. Articles were selected based on their relevance to this review.
  
  
  OBJECTIVE
  To review the literature regarding the involvement of the nuclear factor kappa-B (NF-?B) transcription factor in asthma.
  
  
  RESULTS
  NF-?B is a critical transcription factor for the production of many inflammatory cytokines. NF-?B is associated with several diseases, including asthma, where there is an inflammation of the airways with cell infiltration. It is activated in bronchial asthmatic patient biopsies and active in the epithelium of the airways in mice after stimulation. It also participates in the maintenance of the chronic inflammatory response. NF-?B also acts synergistically with other transcription factors, to induce the maximal expression of genes involved with asthma. Activation of NF- ?B by several stimuli induces the release and degradation of the inhibitory protein I-?B from the dimeric complex followed by translocation of NF-?B to the nucleus.
  
  
  CONCLUSIONS
  The NF-?B pathway is central to the pathogenesis of  asthma. NF?B is an important therapeutic target for the treatment of asthma, including intermediate products on the signaling pathway and protein related to Rel. Alterations in the NF-?B signaling pathway are associated with the disease.
authors.affiliation: División de Investigación.
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Rico-Rosillo
authors.forename: Gloria Bertha
authors.initials: GB
authors.lastname: Vega-Robledo
mesh_terms: D000818:Animals; D001249:Asthma; D016207:Cytokines; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation; D016328:NF-kappa B; D015398:Signal Transduction; D014157:Transcription Factors; D014158:Transcription, Genetic
chemical_list: D016207:Cytokines; D016328:NF-kappa B; D014157:Transcription Factors