title: Potential antibacterial activity of carvacrol-loaded poly(DL-lactide-co-glycolide) (PLGA) nanoparticles against microbial biofilm.
abstract: The ability to form biofilms contributes significantly to the pathogenesis of many microbial infections, including a variety of ocular diseases often associated with the biofilm formation on foreign materials. Carvacrol (Car.) is an important component of essential oils and recently has attracted much attention pursuant to its ability to promote microbial biofilm disruption. In the present study Car. has been encapsulated in poly(dl-lactide-co-glycolide (PLGA) nanocapsules in order to obtain a suitable drug delivery system that could represent a starting point for developing new therapeutic strategies against biofilm-associated infections, such as improving the drug effect by associating an antimicrobial agent with a biofilm viscoelasticity modifier.
authors.affiliation: Department of Drug Sciences, Faculty of Pharmacy; University G. d'Annunzio, Via dei Vestini 31, Chieti 66100, Italy; E-Mails:  aiannitelli@unich.it  (A.I.);  r.grande@unich.it  (R.G.);  m.digiulio@unich.it  (M.G.D.);  p.sozio@unich.it  (P.S.);  ljbesa@unich.it  (L.J.B.);  s.laserra@unich.it  (S.L.);  l.cellini@unich.it  (L.C.).
authors.forename: Antonio
authors.initials: A
authors.lastname: Iannitelli
authors.forename: Rossella
authors.initials: R
authors.lastname: Grande
authors.forename: Antonio
authors.initials: A
authors.lastname: Di Stefano
authors.forename: Mara
authors.initials: M
authors.lastname: Di Giulio
authors.forename: Piera
authors.initials: P
authors.lastname: Sozio
authors.forename: Lucinda Janete
authors.initials: LJ
authors.lastname: Bessa
authors.forename: Sara
authors.initials: S
authors.lastname: Laserra
authors.forename: Cecilia
authors.initials: C
authors.lastname: Paolini
authors.forename: Feliciano
authors.initials: F
authors.lastname: Protasi
authors.forename: Luigina
authors.initials: L
authors.lastname: Cellini
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry; D018441:Biofilms / Q000187:drug effects*; D002626:Chemistry, Pharmaceutical; D000081007:Cymenes; D016503:Drug Delivery Systems; D006801:Humans; D007700:Kinetics; D019344:Lactic Acid / Q000737:chemistry*; D039821:Monoterpenes / Q000008:administration & dosage* / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000502:physiology
chemical_list: D000900:Anti-Bacterial Agents; D000081007:Cymenes; D039821:Monoterpenes; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C073316:carvacrol