title: Nonlinear models of development, amplification and compression in the mammalian cochlea.
abstract: This paper reviews current understanding and presents new results on some of the nonlinear processes that underlie the function of the mammalian cochlea. These processes occur within mechano-sensory hair cells that form part of the organ of Corti. After a general overview of cochlear physiology, mathematical modelling results are presented in three parts. First, the dynamic interplay between ion channels within the sensory inner hair cells is used to explain some new electrophysiological recordings from early development. Next, the state of the art is reviewed in modelling the electro-motility present within the outer hair cells (OHCs), including the current debate concerning the role of cell body motility versus active hair bundle dynamics. A simplified model is introduced that combines both effects in order to explain observed amplification and compression in experiments. Finally, new modelling evidence is presented that structural longitudinal coupling between OHCs may be necessary in order to capture all features of the observed mechanical responses.
authors.affiliation: Department of Engineering Mathematics, University of Bristol, Bristol BS8 1TR, UK. r.szalai@bristol.ac.uk
authors.forename: R
authors.initials: R
authors.lastname: Szalai
authors.forename: K
authors.initials: K
authors.lastname: Tsaneva-Atanasova
authors.forename: M E
authors.initials: ME
authors.lastname: Homer
authors.forename: A R
authors.initials: AR
authors.lastname: Champneys
authors.forename: H J
authors.initials: HJ
authors.lastname: Kennedy
authors.forename: N P
authors.initials: NP
authors.lastname: Cooper
mesh_terms: D000465:Algorithms; D000818:Animals; D001703:Biophysics / Q000379:methods; D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D003051:Cochlea / Q000196:embryology / Q000502:physiology*; D004563:Electrochemistry; D006198:Hair Cells, Auditory / Q000502:physiology; D006309:Hearing / Q000502:physiology; D006801:Humans; D007473:Ion Channels; D008954:Models, Biological; D008962:Models, Theoretical; D017711:Nonlinear Dynamics; D012533:Scala Tympani / Q000473:pathology
chemical_list: D007473:Ion Channels; D002118:Calcium