title: [The influence of tripterygium hypoglaucum hutch on the HIF-1α  expression in the CIA rat models].
abstract: OBJECTIVE
  To investigate the effect of tripterygium hypoglaucum hutch (THH) on the expression of hypoxi induciable factor (HIF-1α) in rats with collagen induced arthritis (CIA) model and its mechanism.
  
  
  METHODS
  Establish CIA model rat,  group randomly,  treat groups with gastric feeding at High,  Medium and Low doses of THH once a day,  with continuous medication for 30 days. Record arthritis index (AI) and joint pathology change. Detect HIF-1α mRNA and protein expression with PT-PCR and immunohistochemical staining.
  
  
  RESULTS
  THH could inhibit paw swelling in CIA rats,  reduce synovial proliferation and inflammatory response significantly.
  
  
  CONCLUSIONS
  THH may mitigate joint inflammation of CIA model rat through reduction of HIF-1α expression.
authors.affiliation: Department of Biochemistry and Molecularbiology, Guilin Medical College, Guilin, China. bl93@glmc.edu.cn
authors.forename: Ling
authors.initials: L
authors.lastname: Bai
authors.forename: Sen-zhou
authors.initials: SZ
authors.lastname: Chen
authors.forename: Shuang
authors.initials: S
authors.lastname: Liang
authors.forename: Sha-sha
authors.initials: SS
authors.lastname: Li
authors.forename: Wen
authors.initials: W
authors.lastname: Wang
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use*; D012333:RNA, Messenger / Q000378:metabolism; D011859:Radiography; D051381:Rats; D017208:Rats, Wistar; D029757:Tripterygium
chemical_list: D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D028321:Plant Preparations; D012333:RNA, Messenger