title: Tc-99m sestamibi scintimammography for the diagnosis of breast cancer:  meta-analysis and meta-regression.
abstract: Tc-99m sestamibi (MIBI) is a relatively noninvasive diagnostic modality in the evaluation of breast cancer. The purpose of this study was to review the existing literature on the accuracy of Tc-99m MIBI in the diagnosis of breast cancer. After a systematic review of English-language studies, the sensitivity, specificity, and other measures of accuracy of Tc-99m MIBI in the diagnosis of breast cancer were pooled using random-effects models. Summary receiver operating characteristic curves were used to summarize the overall test performance. Forty-five studies met our inclusion criteria. The summary estimates for Tc-99m MIBI in the diagnosis of breast cancer in the studies included were as follows: sensitivity, 0.83 [95% confidence interval (CI), 0.82-0.84]; specificity, 0.85 (95% CI, 0.83-0.86); positive likelihood ratio, 5.06 (95% CI, 4.26-6.01); negative likelihood ratio, 0.20 (95% CI, 0.17-0.24); and diagnostic odds ratio, 27.63 (95% CI, 21.63-36.10). For patients with a palpable mass, the sensitivity and specificity were 87 and 86%, respectively. For patients without a palpable mass, the sensitivity and specificity were 59 and 89%, respectively. Tc-99m MIBI has a high level of overall accuracy for the diagnosis of breast cancer.
authors.affiliation: Department of Clinical Pharmacy, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China. xuhongbin119@yahoo.cn
authors.forename: Hong-Bin
authors.initials: HB
authors.lastname: Xu
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.forename: Qing
authors.initials: Q
authors.lastname: Xu
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012044:Regression Analysis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D017256:Technetium Tc 99m Sestamibi
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi