title: Shape-memory surface with dynamically tunable nano-geometry activated by body heat.
abstract: Shape-memory surfaces with on-demand, tunable nanopatterns are developed to observe time dependent changes in cell alignment using temperature-responsive poly(ϵ-caprolactone) (PCL) films. Temporary grooved nanopatterns are easily programmed on the films and triggered to transition quickly to permanent surface patterns by the application of body heat. A time-dependent cytoskeleton remodeling is also observed under biologically relevant conditions.
authors.affiliation: Biomaterials Unit, International Research Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), Tsukuba, Ibaraki, Japan.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Ebara
authors.forename: Koichiro
authors.initials: K
authors.lastname: Uto
authors.forename: Naokazu
authors.initials: N
authors.lastname: Idota
authors.forename: John M
authors.initials: JM
authors.lastname: Hoffman
authors.forename: Takao
authors.initials: T
authors.lastname: Aoyagi
mesh_terms: D000818:Animals; D002460:Cell Line; D003599:Cytoskeleton; D051379:Mice; D018625:Microscopy, Atomic Force; D049329:Nanostructures / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry; D013499:Surface Properties; D013997:Time Factors; D044366:Transition Temperature
chemical_list: D011091:Polyesters; C016240:polycaprolactone