title: Clinical outcomes of fertility-sparing treatments in young patients with epithelial ovarian carcinoma.
abstract: OBJECTIVE
  To assess the clinical outcomes of fertility-sparing treatments in young patients with epithelial ovarian carcinoma (EOC).
  
  
  METHODS
  A retrospective study of young EOC inpatients (≤40 years old) was performed during January 1994 and December 2010 in eight institutions.
  
  
  RESULTS
  Data were analyzed from 94 patients treated with fertility-sparing surgery with a median follow-up time of 58.7 months. As histologic grade increased, overall survival (OS) and disease-free survival (DFS) of patients receiving fertility-sparing surgery declined. Neither staging surgery nor laparoscopy of early stage EOC with conservative surgery had a significant effect on OS or DFS. Normal menstruation recommenced after chemotherapy in 89% of the fertility-sparing group. Seventeen pregnancies among twelve patients were achieved by the end of the follow-ups.
  
  
  CONCLUSIONS
  Fertility-sparing treatment for patients with EOC Stage I Grade 1 could be cautiously considered for young patients. The surgical procedure and surgical route might not significantly influence the prognosis. Standard chemotherapy is not likely to have an evident impact on ovarian function or fertility in young patients.
authors.affiliation: Department of Gynecology, Peking University First Hospital, Beijing, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Hu
authors.forename: Li-rong
authors.initials: LR
authors.lastname: Zhu
authors.forename: Zhi-qing
authors.initials: ZQ
authors.lastname: Liang
authors.forename: Yuan-guang
authors.initials: YG
authors.lastname: Meng
authors.forename: Hong-yan
authors.initials: HY
authors.lastname: Guo
authors.forename: Peng-peng
authors.initials: PP
authors.lastname: Qu
authors.forename: Cai-ling
authors.initials: CL
authors.lastname: Ma
authors.forename: Cong-jian
authors.initials: CJ
authors.lastname: Xu
authors.forename: Bi-bo
authors.initials: BB
authors.lastname: Yuan
mesh_terms: D000328:Adult; D000077216:Carcinoma, Ovarian Epithelial; D018572:Disease-Free Survival; D005260:Female; D005298:Fertility / Q000187:drug effects; D059247:Fertility Preservation; D006801:Humans; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000188:drug therapy / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D010053:Ovary / Q000187:drug effects / Q000502:physiology; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult