title: Quantitative autism traits in first degree relatives: evidence for the broader autism phenotype in fathers, but not in mothers and siblings.
abstract: Autism spectrum disorder (ASD) symptoms are present in unaffected relatives and individuals from the general population. Results are inconclusive, however, on whether unaffected relatives have higher levels of quantitative autism traits (QAT) or not. This might be due to differences in research populations, because behavioral data and molecular genetic research suggest that the genetic etiology of ASD is different in multiplex and simplex families. We compared 117 unaffected siblings and 276 parents of at least one child with ASD with 280 children and 595 adults from the general population on the presence of QAT using the Social Responsiveness Scale (SRS). Mean SRS scores for siblings, control children, parents and control adults were 25.4, 26.6, 33.7 and 32.9. Fathers of children with ASD showed significantly higher levels of QAT than controls, but siblings and mothers did not. We could not detect a statistically significant difference in SRS scores between relatives from simplex and multiplex families. These results do not support the theory of differential (genetic) etiology in multiplex and simplex families and suggest that a carried genetic risk is generally not expressed phenotypically in most relatives, except in fathers.
authors.affiliation: Child and Adolescent Psychiatry Department and Leuven Autism Research, UPC-K.U.Leuven, Leuven, Belgium.
authors.forename: Wouter
authors.initials: W
authors.lastname: De la Marche
authors.forename: Ilse
authors.initials: I
authors.lastname: Noens
authors.forename: Jan
authors.initials: J
authors.lastname: Luts
authors.forename: Evert
authors.initials: E
authors.lastname: Scholte
authors.forename: Sabine
authors.initials: S
authors.lastname: Van Huffel
authors.forename: Jean
authors.initials: J
authors.lastname: Steyaert
mesh_terms: D000293:Adolescent; D000328:Adult; D001530:Belgium / Q000453:epidemiology; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000453:epidemiology / Q000235:genetics*; D002675:Child, Preschool; D005190:Family; D005220:Fathers; D005260:Female; D006801:Humans; D008297:Male; D009035:Mothers; D010641:Phenotype; D011569:Psychiatric Status Rating Scales; D035781:Siblings