title: Human-leukocyte antigen class I Cw 1502 and class II DR 0301 genotypes are associated with resistance to severe acute respiratory syndrome (SARS) infection.
abstract: One-hundred and thirty confirmed cases of severe acute respiratory syndrome (SARS) were recruited to evaluate their anti-SARS-coronavirus (CoV) antibody status and human leukocyte antigen (HLA) types in September 2006, 3 y after the SARS outbreaks in Taiwan. Western blot assay showed that 6.9% of participants still had anti-spike and anti-nucleocapside antibodies. A case-control study of the association of HLA with SARS revealed that the HLA-Cw1502 and DR0301 alleles conferred resistance against SARS infection (p<0.05).
authors.affiliation: Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
authors.forename: Sheng-Fan
authors.initials: SF
authors.lastname: Wang
authors.forename: Kuan-Hsuan
authors.initials: KH
authors.lastname: Chen
authors.forename: Marcelo
authors.initials: M
authors.lastname: Chen
authors.forename: Wen-Yi
authors.initials: WY
authors.lastname: Li
authors.forename: Yen-Ju
authors.initials: YJ
authors.lastname: Chen
authors.forename: Ching-Han
authors.initials: CH
authors.lastname: Tsao
authors.forename: Muh-yong
authors.initials: MY
authors.lastname: Yen
authors.forename: Jason C
authors.initials: JC
authors.lastname: Huang
authors.forename: Yi-Ming Arthur
authors.initials: YM
authors.lastname: Chen
mesh_terms: D000328:Adult; D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood*; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D060467:Disease Resistance / Q000235:genetics* / Q000276:immunology; D005260:Female; D005838:Genotype; D015236:HLA-C Antigens / Q000235:genetics*; D015803:HLA-DR3 Antigen / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D045473:Severe acute respiratory syndrome-related coronavirus / Q000276:immunology / Q000472:pathogenicity; D045169:Severe Acute Respiratory Syndrome / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D013624:Taiwan / Q000453:epidemiology
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D015236:HLA-C Antigens; C500432:HLA-DR0301 antigen; D015803:HLA-DR3 Antigen