title: Nanofluidic devices for rapid continuous-flow bioseparation.
abstract: Compared with conventional gel-based techniques, such as gel electrophoresis, which are routinely used for bioseparation in biology and biomedical laboratories, nanofluidic devices with regular engineered sieving structures offer the potential for faster separation, better resolution, higher throughput, and more convenient sample recovery. Here, we detail the fabrication process of a two-dimensional nanofluidic filter array device and its implementation for rapid continuous-flow separation of biomolecules such as proteins.
authors.affiliation: Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
authors.forename: Pan
authors.initials: P
authors.lastname: Mao
authors.forename: Jianping
authors.initials: J
authors.lastname: Fu
mesh_terms: D005591:Chemical Fractionation / Q000295:instrumentation*; D036103:Nanotechnology / Q000295:instrumentation*; D011506:Proteins / Q000302:isolation & purification*; D013997:Time Factors
chemical_list: D011506:Proteins