title: Aryl aldehydes as traceless dielectrophiles in bifunctional titanocene-catalyzed propargylic C-X activations.
abstract: The titanocene-catalyzed construction of all-carbon substituted tertiary centers directly from aromatic aldehydes is described. The starting aldehyde behaves as a traceless functionality in the formation of multiple carbon-carbon bonds through consecutive carbon-heteroatom bond activations. The sequential addition of a metal acetylide and a second carbon nucleophile to the dielectrophilic aldehyde enables the construction of symmetrical and unsymmetrical 1,4-diynes in good yields.
authors.affiliation: Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA.
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Campos
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Gianino
authors.forename: David M
authors.initials: DM
authors.lastname: Pinkerton
authors.forename: Brandon L
authors.initials: BL
authors.lastname: Ashfeld