title: Weekly exercise does not improve fatigue levels in Parkinson's disease.
abstract: BACKGROUND
  Fatigue is one of the most disabling non-motor symptoms for people with Parkinson's disease. Exercise may modify fatigue. This study examines prescribed exercise effects on physical activity levels, well-being, and fatigue in Parkinson's disease.
  
  
  METHODS
  In this single-blinded trial, participants were randomly assigned to either a 12 week community exercise program or control group. Primary outcome measures were fatigue (Fatigue Severity Scale) and physical activity.
  
  
  RESULTS
  Thirty-nine people with Parkinson's disease were included: 20 in exercise and 19 in control. Sixty-five percent of the study group were fatigued (n = 24, mean 4.02, SD 1.48). Increased fatigue was associated with lower mobility and activity (P < .05). Individuals participated in a mean of 15 (SD 10) exercise sessions with no significant change in fatigue, mobility, well-being, or physical activity after exercise (P ≥ .05).
  
  
  CONCLUSIONS
  Participation in weekly exercise did not improve fatigue in people with Parkinson's Disease.
authors.affiliation: Movement Science Group, School of Life Sciences, Oxford Brookes University, Oxford, UK. Charlie.winward@noc.nhs.uk
authors.forename: Charlotte
authors.initials: C
authors.lastname: Winward
authors.forename: Cath
authors.initials: C
authors.lastname: Sackley
authors.forename: Charmaine
authors.initials: C
authors.lastname: Meek
authors.forename: Hooshang
authors.initials: H
authors.lastname: Izadi
authors.forename: Karen
authors.initials: K
authors.lastname: Barker
authors.forename: Derick
authors.initials: D
authors.lastname: Wade
authors.forename: Helen
authors.initials: H
authors.lastname: Dawes
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D005081:Exercise Therapy / Q000379:methods*; D005221:Fatigue / Q000209:etiology* / Q000534:rehabilitation*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology; D010300:Parkinson Disease / Q000150:complications*; D012720:Severity of Illness Index; D016037:Single-Blind Method; D011795:Surveys and Questionnaires