title: [Update on HPV-induced oropharyngeal cancer].
abstract: Oropharyngeal squamous cell carcinoma (OSCC) is associated with oncogenic human papillomavirus (HPV) infection in 30-40% of all cases in Germany. The use of PCR and / or in situ hybridisation to detect HPV in tumour tissue is used in combination with p16 immunohistochemistry to reliably distinguish HPV-related and HPV-unrelated OSCC. The distinct biological behaviour of the HPV-related subset of OSCC results in a more favourable prognosis. This might be the result of a greater response to chemotherapy and radiotherapy as seen in recent studies. Ongoing and future clinical trials will stratify for HPV status. If the results of these prospective, randomized trials are consistent with the preliminary results of recent studies, HPV status will be of enormous clinical relevance in the future.
authors.affiliation: Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde, Kopf-Hals-Chirurgie, Klinikum der Universität zu Köln, Kerpener Str. 62, 50924, Köln, Deutschland. simon.preuss@uni-koeln.de
authors.forename: S F
authors.initials: SF
authors.lastname: Preuss
authors.forename: J-P
authors.initials: JP
authors.lastname: Klussmann
authors.forename: R
authors.initials: R
authors.lastname: Semrau
authors.forename: C
authors.initials: C
authors.lastname: Huebbers
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D015344:DNA Probes, HPV; D019942:Genes, p16; D052162:Human papillomavirus 16; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D060828:Induction Chemotherapy; D009367:Neoplasm Staging; D009959:Oropharyngeal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D016133:Polymerase Chain Reaction; D011379:Prognosis
chemical_list: D015344:DNA Probes, HPV