title: Primary diffuse large B-cell lymphoma of the testis.
abstract: In this short review, we discuss primary diffuse large B-cell lymphoma of the testis, an entity that is most commonly seen in older patients. The most common clinical presentation is a unilateral testicular mass. Microscopically, the tumor shows diffuse infiltration of lymphocytes between intact seminiferous tubules. Spermatogenic arrest, interstitial fibrosis, and tubular hyalinization are commonly seen. The tumor is positive for B-cell markers by immunohistochemistry. Treatment has traditionally been with orchiectomy and combination chemotherapy; however, only a minority of patients enjoy a prolonged disease-free survival. Differential diagnosis includes seminoma and viral and granulomatous orchitis.
authors.affiliation: Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06519, USA.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Horne
authors.forename: Adebowale J
authors.initials: AJ
authors.lastname: Adeniran
mesh_terms: D003937:Diagnosis, Differential; D019254:Genes, bcl-2; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D008297:Male; D009154:Mutation; D011379:Prognosis; D013736:Testicular Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy