title: New therapeutic strategies for the treatment of patent ductus arteriosus.
abstract: In the present manuscript we will focus our attention on the drug choice and its dosage.some studies suggest that the failure of pharmacologic pda closure might be due to the inadequacy of the standard dose regimen, because of large interindividual pharmacokinetics and pharmacodynamic variations in premature infants. we discuss the possibility that the early treatment of pda with ibuprofen doses higher than those actually recommended might increase the closure rate in preterm infants.
authors.affiliation: Department of Medical and Surgical Critical Care, Section of Neonatology, Careggi University Hospital of Florence, Florence, Italy. cdani@unifi.it
authors.forename: Carlo
authors.initials: C
authors.lastname: Dani
mesh_terms: D004305:Dose-Response Relationship, Drug; D054796:Drug Dosage Calculations; D004374:Ductus Arteriosus, Patent / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy*; D035703:Therapies, Investigational / Q000379:methods*