title: A new method for aromatic difluoromethylation: copper-catalyzed cross-coupling and decarboxylation sequence from aryl iodides.
abstract: A new methodology for aromatic difluoromethylation is described. Aryl iodides reacted with α-silyldifluoroacetates upon treatment with copper catalyst in DMSO or DME to give the corresponding aryldifluoroacetates in moderate to good yields. The subsequent hydrolysis of aryldifluoroacetates and KF-promoted decarboxylation afforded a variety of difluoromethyl aromatics.
authors.affiliation: Department of Chemistry, Graduate School of Science, Kobe University, Kobe 657-8501, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Fujikawa
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Fujioka
authors.forename: Akira
authors.initials: A
authors.lastname: Kobayashi
authors.forename: Hideki
authors.initials: H
authors.lastname: Amii
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003653:Decarboxylation; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D006847:Hydrocarbons, Iodinated / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D006845:Hydrocarbons, Fluorinated; D006847:Hydrocarbons, Iodinated; D003300:Copper