title: Phenobarbital and temperature profile during hypothermia for hypoxic-ischemic encephalopathy.
abstract: Data from the whole-body hypothermia trial was analyzed to examine the effects of phenobarbital administration prior to cooling (+PB) on the esophageal temperature (T               (e)) profile, during the induction phase of hypothermia. A total of 98 infants were analyzed. At enrollment, +PB infants had a higher rate of severe hypoxic-ischemic encephalopathy and clinical seizures and lower T               (e) and cord pH than infants that have not received phenobarbital (-PB). There was a significant effect of phenobarbital itself and an interaction between phenobarbital and time in the T               (e) profile. Mean T               (e) in the +PB group was lower than in the -PB group, and the differences decreased over time. In +PB infants, the time to surpass target T               (e) of 33.5°C and to reach the minimum T               (e) during overshoot were shorter. In conclusion, the administration of phenobarbital before cooling was associated with changes that may reflect a reduced thermogenic response associated with barbiturates.
authors.affiliation: McGill University, Montreal, Quebec, Canada. guilherme.santanna@mcgill.ca
authors.forename: Guilherme
authors.initials: G
authors.lastname: Sant'Anna
authors.forename: Abbot R
authors.initials: AR
authors.lastname: Laptook
authors.forename: Seetha
authors.initials: S
authors.lastname: Shankaran
authors.forename: Rebecca
authors.initials: R
authors.lastname: Bara
authors.forename: Scott A
authors.initials: SA
authors.lastname: McDonald
authors.forename: Rosemary D
authors.initials: RD
authors.lastname: Higgins
authors.forename: Jon E
authors.initials: JE
authors.lastname: Tyson
authors.forename: Richard A
authors.initials: RA
authors.lastname: Ehrenkranz
authors.forename: Abhik
authors.initials: A
authors.lastname: Das
authors.forename: Ronald N
authors.initials: RN
authors.lastname: Goldberg
authors.forename: Michele C
authors.initials: MC
authors.lastname: Walsh
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D001831:Body Temperature / Q000187:drug effects / Q000502:physiology; D003080:Cold Temperature; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D020925:Hypoxia-Ischemia, Brain / Q000628:therapy*; D007223:Infant; D008297:Male; D010634:Phenobarbital / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D010634:Phenobarbital