title: Antiemetics: American Society of Clinical Oncology clinical practice guideline update.
abstract: OBJECTIVE
  To update the American Society of Clinical Oncology (ASCO) guideline for antiemetics in oncology.
  
  
  METHODS
  A systematic review of the medical literature was completed to inform this update. MEDLINE, the Cochrane Collaboration Library, and meeting materials from ASCO and the Multinational Association for Supportive Care in Cancer were all searched. Primary outcomes of interest were complete response and rates of any vomiting or nausea.
  
  
  RESULTS
  Thirty-seven trials met prespecified inclusion and exclusion criteria for this systematic review. Two systematic reviews from the Cochrane Collaboration were identified; one surveyed the pediatric literature. The other compared the relative efficacy of the 5-hydroxytryptamine-3 (5-HT(3)) receptor antagonists.
  
  
  CONCLUSIONS
  Combined anthracycline and cyclophosphamide regimens were reclassified as highly emetic. Patients who receive this combination or any highly emetic agents should receive a 5-HT(3) receptor antagonist, dexamethasone, and a neurokinin 1 (NK(1)) receptor antagonist. A large trial validated the equivalency of fosaprepitant, a single-day intravenous formulation, with aprepitant; either therapy is appropriate. Preferential use of palonosetron is recommended for moderate emetic risk regimens, combined with dexamethasone. For low-risk agents, patients can be offered dexamethasone before the first dose of chemotherapy. Patients undergoing high emetic risk radiation therapy should receive a 5-HT(3) receptor antagonist before each fraction and for 24 hours after treatment and may receive a 5-day course of dexamethasone during fractions 1 to 5. The Update Committee noted the importance of continued symptom monitoring throughout therapy. Clinicians underestimate the incidence of nausea, which is not as well controlled as emesis.
authors.affiliation: Memorial Sloan-Kettering Cancer Center, New York, USA.
authors.forename: Ethan
authors.initials: E
authors.lastname: Basch
authors.forename: Ann Alexis
authors.initials: AA
authors.lastname: Prestrud
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Hesketh
authors.forename: Mark G
authors.initials: MG
authors.lastname: Kris
authors.forename: Petra C
authors.initials: PC
authors.lastname: Feyer
authors.forename: Mark R
authors.initials: MR
authors.lastname: Somerfield
authors.forename: Maurice
authors.initials: M
authors.lastname: Chesney
authors.forename: Rebecca Anne
authors.initials: RA
authors.lastname: Clark-Snow
authors.forename: Anne Marie
authors.initials: AM
authors.lastname: Flaherty
authors.forename: Barbara
authors.initials: B
authors.lastname: Freundlich
authors.forename: Gary
authors.initials: G
authors.lastname: Morrow
authors.forename: Kamakshi V
authors.initials: KV
authors.lastname: Rao
authors.forename: Rowena N
authors.initials: RN
authors.lastname: Schwartz
authors.forename: Gary H
authors.initials: GH
authors.lastname: Lyman
mesh_terms: D000932:Antiemetics / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D000077608:Aprepitant; D003907:Dexamethasone / Q000008:administration & dosage; D004334:Drug Administration Schedule; D006801:Humans; D007262:Infusions, Intravenous; D007546:Isoquinolines / Q000008:administration & dosage; D009025:Morpholines / Q000008:administration & dosage; D009325:Nausea / Q000139:chemically induced / Q000188:drug therapy* / Q000209:etiology*; D064729:Neurokinin-1 Receptor Antagonists; D000077924:Palonosetron; D011812:Quinuclidines / Q000008:administration & dosage; D011878:Radiotherapy / Q000009:adverse effects*; D012702:Serotonin Antagonists / Q000008:administration & dosage; D011795:Surveys and Questionnaires; D014839:Vomiting / Q000139:chemically induced / Q000188:drug therapy / Q000209:etiology* / Q000517:prevention & control*
chemical_list: D000932:Antiemetics; D000970:Antineoplastic Agents; D007546:Isoquinolines; D009025:Morpholines; D064729:Neurokinin-1 Receptor Antagonists; D011812:Quinuclidines; D012702:Serotonin Antagonists; D000077608:Aprepitant; D000077924:Palonosetron; C579707:fosaprepitant; D003907:Dexamethasone