title: [Content of chaperon Hsp70 in dopaminergic neurons of the black substance increases in proteasome dysfunstion].
abstract: In Wistar rats, specific inhibitor UPS lactacystin induced degeneration of 24% of the dopaminergic neurons in the black substance. The work shows that a moderate weakening of the UPS function is characterized by an enhanced activity of the shaperon system. This process seems to restore and maintain population of the dopaminergic neurons.
authors.forename: Iu F
authors.initials: IuF
authors.lastname: Pastukhov
authors.forename: I V
authors.initials: IV
authors.lastname: Ekimova
authors.forename: I V
authors.initials: IV
authors.lastname: Guzhova
authors.forename: I V
authors.initials: IV
authors.lastname: Romanova
authors.forename: Z E
authors.initials: ZE
authors.lastname: Artiukhina
mesh_terms: D000111:Acetylcysteine / Q000031:analogs & derivatives / Q000494:pharmacology; D000375:Aging / Q000502:physiology; D000818:Animals; D001426:Bacterial Proteins / Q000032:analysis; D001710:Biotin / Q000031:analogs & derivatives / Q000032:analysis; D015153:Blotting, Western; D002404:Catheterization; D015853:Cysteine Proteinase Inhibitors / Q000494:pharmacology; D004195:Disease Models, Animal; D004298:Dopamine / Q000494:pharmacology; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D008845:Microinjections; D018613:Microscopy, Confocal; D009474:Neurons / Q000166:cytology / Q000187:drug effects*; D010300:Parkinson Disease / Q000473:pathology / Q000503:physiopathology; D046988:Proteasome Endopeptidase Complex / Q000187:drug effects* / Q000378:metabolism; D061988:Proteasome Inhibitors; D051381:Rats; D017208:Rats, Wistar; D013378:Substantia Nigra / Q000187:drug effects / Q000473:pathology* / Q000503:physiopathology; D014446:Tyrosine 3-Monooxygenase / Q000096:biosynthesis*; D025801:Ubiquitin / Q000037:antagonists & inhibitors / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D001426:Bacterial Proteins; D015853:Cysteine Proteinase Inhibitors; D018840:HSP70 Heat-Shock Proteins; D061988:Proteasome Inhibitors; D025801:Ubiquitin; C066114:biotin-streptavidin complex; C067713:lactacystin; D001710:Biotin; D014446:Tyrosine 3-Monooxygenase; D046988:Proteasome Endopeptidase Complex; D004298:Dopamine; D000111:Acetylcysteine