title: Usefulness of monitoring linezolid trough serum concentration in prolonged treatments.
abstract: Linezolid has proven valuable in musculoskeletal infections, however, failure and resistance have been described and toxicity is worrisome when more than 28 days are necessary. We describe the first 5 cases in whom linezolid trough serum concentrations were weekly measured and its relationship with clinical outcome and toxicity.
authors.affiliation: Orthopaedics Department, Hospital Santo António - Centro Hospitalar do Porto, Oporto, Portugal.
authors.forename: R
authors.initials: R
authors.lastname: Sousa
authors.forename: R
authors.initials: R
authors.lastname: López
authors.forename: J C
authors.initials: JC
authors.lastname: Martínez-Pastor
authors.forename: C
authors.initials: C
authors.lastname: Cervera
authors.forename: G
authors.initials: G
authors.lastname: Bori
authors.forename: S
authors.initials: S
authors.lastname: García-Ramiro
authors.forename: J
authors.initials: J
authors.lastname: Mensa
authors.forename: A
authors.initials: A
authors.lastname: Soriano
mesh_terms: D000081:Acetamides / Q000097:blood* / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000097:blood* / Q000627:therapeutic use*; D016903:Drug Monitoring; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D006095:Gram-Positive Cocci; D006801:Humans; D000069349:Linezolid; D008297:Male; D008875:Middle Aged; D009140:Musculoskeletal Diseases / Q000188:drug therapy / Q000382:microbiology; D019637:Orthopedic Procedures; D023303:Oxazolidinones / Q000097:blood* / Q000627:therapeutic use*; D016459:Prosthesis-Related Infections / Q000188:drug therapy* / Q000382:microbiology; D016896:Treatment Outcome
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid