title: [Correlation between expression of HIF-2α and  OCT-4 and  prognosis of NSCLC].
abstract: OBJECTIVE
  To investigate the expression and significance of hypoxia inducible factor-2α (HIF-2α) and transcription factor OCT-4 in non-small cell lung cancer (NSCLC), and evaluate their roles in the prognosis of NSCLC.
  
  
  METHODS
  Tissues from 51 cases of NSCLC were collected and immunohistochemistry (SP method) was used to detect the expression of HIF-2α and OCT-4 proteins. The correlation between the protein expression and the prognosis of NSCLC was analyzed.
  
  
  RESULTS
  The positive rates of HIF-2α and OCT-4 expression in the NSCLC were 52.9% and 72.5%, respectively. There was significant relation between the expression of HIF-2α and OCT-4 (r=0.514,P<0.01). High expression of them revealed poor prognosis for NSCLC patients characterized with a bad overall survival(P<0.05).
  
  
  CONCLUSIONS
  There is a negative corelation between the expression of HIF-2α and OCT-4 and the prognosis of NSCLC. Combined examination of HIF-2α and OCT-4 expression might be an important biomarker for NSCLC prognosis.
authors.affiliation: Department of Oncology, Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Linfang
authors.initials: L
authors.lastname: Wei
authors.forename: Xianling
authors.initials: X
authors.lastname: Liu
authors.forename: Chunhong
authors.initials: C
authors.lastname: Hu
mesh_terms: D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D008297:Male; D050814:Octamer Transcription Factor-3 / Q000378:metabolism*; D011379:Prognosis; D000099162:Endothelial PAS Domain-Containing Protein 1
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D014408:Biomarkers, Tumor; D050814:Octamer Transcription Factor-3; D000099162:Endothelial PAS Domain-Containing Protein 1; C494173:POU5F1 protein, human