title: Synthesis and anti-inflammatory activity of some new 4,5-dihydro-1,5-diaryl-1H-pyrazole-3-substituted-heteroazole derivatives.
abstract: A series of 4,5-dihydro-1,5-diaryl-1H-pyrazole-3-substituted-heteroazoles were designed and synthesized in order to obtain new compounds with potential anti-inflammatory activity. The title compounds were screened for in vivo anti-inflammatory activity by using Carrageenan induced rat paw edema method. Diclofenac sodium was used as a standard drug for comparison. Out of the 30 compounds tested, compound 19a, 19b, 25a, 25b exhibited significant anti-inflammatory activity. Selected compounds were also screened for in vitro COX-2 inhibition assay and analgesic activity in the acetic acid induced writhing model.
authors.affiliation: Department of Chemistry, Vinyakrao Patil Mahavidyala Vaijapur, Aurangabad, MS 423701, India.
authors.forename: Deepak V
authors.initials: DV
authors.lastname: Dekhane
authors.forename: Shivaji S
authors.initials: SS
authors.lastname: Pawar
authors.forename: Sunil
authors.initials: S
authors.lastname: Gupta
authors.forename: Murlidhar S
authors.initials: MS
authors.lastname: Shingare
authors.forename: C R
authors.initials: CR
authors.lastname: Patil
authors.forename: Shivaji N
authors.initials: SN
authors.lastname: Thore
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001393:Azoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D051381:Rats
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001393:Azoles