title: Secoiridoid glucosides and related compounds from Syringa reticulata and their antioxidant activities.
abstract: A 70% EtOH extract from the bark of Syringareticulata has shown significant antioxidant activity. Chemical study on the extract resulted in the isolation of seventeen compounds (1-17), including a novel oleoside-type secoiridoid glucoside, reticuloside (1), and the structures were elucidated on the basis of extensive spectroscopic analyses. Among the isolated compounds, jaspolyoside (2), oleuropein (4) and 2-(3,4-dihydroxy)-phenylethyl-β-d-glucopyranoside (17), showed the most potent superoxide anion scavenging activity with the EC(50) values of 4.97, 2.57 and 4.97μM, respectively. The structure-activity relationship indicated that the presence of 2-(3,4-dihydroxyphenyl)-ethoxy group is important for exhibiting the activity.
authors.affiliation: Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan.
authors.forename: Xueyan
authors.initials: X
authors.lastname: Bi
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Tatsunori
authors.initials: T
authors.lastname: Sasaki
authors.forename: Qin
authors.initials: Q
authors.lastname: Li
authors.forename: Naoko
authors.initials: N
authors.lastname: Mitsuhata
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Asada
authors.forename: Qingbo
authors.initials: Q
authors.lastname: Zhang
authors.forename: Kazuo
authors.initials: K
authors.lastname: Koike
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D057888:Iridoid Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013329:Structure-Activity Relationship; D031662:Syringa / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D057888:Iridoid Glucosides