title: Transfer factor and allergy.
abstract: Although various mechanisms involving antibodies and various cell types participate, a Thl and Th2 cells imbalance seems to play a central role for allergy development. Other lymphocyte subpopulations, such as Th17, CD4 FOXP3, and Th9 positive regulatory T lymphocytes may also be involved in the allergic response. Regulatory processes are an appealing target for therapeutic approaches aiming to solve allergic reactions by restoring the delicate balance within the immune system. Transfer factor (TF) or dialyzable leukocyte extract is meant to transfer cell-mediated immunity from immune competent donors to unsensitized or deficient recipients. A PubMed search on the current knowledge on TF indicates that TF may restore the Th1/Th2 balance and improve immune regulatory mechanisms of patients receiving it. Our preliminary results demonstrate that TF induces mRNA expression of IFN-g, osteopontin, RANTES, and hBD-2 in human healthy subjects. TF has been used to treat a variety of immune dysfunction related-pathologies, such as allergy, autoimmunity, immunodeficiencies, infectious diseases and tumors. Patients receiving TF together with their conventional treatment often have better clinical evolution than without it, as we have witnessed, adding TF to the usual medical treatment of allergic diseases as an attempt to provide allergic patients with those regulatory elements that they apparently lack but require to achieve properly regulated immune responses and thus obtain a faster and better resolution of allergic reactions.
authors.affiliation: Immunology and Allergy Unit, Adolfo Lopez Mateos Hospital, ISSSTE, Mexico. iestrada@encb.ipn.mx.
authors.forename: Javier
authors.initials: J
authors.lastname: Gómez Vera
authors.forename: Raúl
authors.initials: R
authors.lastname: Chávez Sánchez
authors.forename: Graciela
authors.initials: G
authors.lastname: Flores Sandoval
authors.forename: Modesto
authors.initials: M
authors.lastname: Orea Solano
authors.forename: José Jesús
authors.initials: JJ
authors.lastname: López Tiro
authors.forename: A D
authors.initials: AD
authors.lastname: Santiago Santos
authors.forename: Sara
authors.initials: S
authors.lastname: Espinosa Padilla
authors.forename: Francisco
authors.initials: F
authors.lastname: Espinosa Rosales
authors.forename: J
authors.initials: J
authors.lastname: Huerta
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Ortega Martell
authors.forename: Renato
authors.initials: R
authors.lastname: Berrón Pérez
authors.forename: Alejandro
authors.initials: A
authors.lastname: Estrada García
authors.forename: Mayra
authors.initials: M
authors.lastname: Pérez Tapia
authors.forename: Azucena
authors.initials: A
authors.lastname: Rodríguez Flores
authors.forename: Ernestina
authors.initials: E
authors.lastname: Serrano Miranda
authors.forename: Oscar
authors.initials: O
authors.lastname: Pineda García
authors.forename: Consuelo
authors.initials: C
authors.lastname: Andaluz
authors.forename: Edgar
authors.initials: E
authors.lastname: Cervantes Trujano
authors.forename: Abraham
authors.initials: A
authors.lastname: Portugués Díaz
authors.forename: Javier
authors.initials: J
authors.lastname: Barrientos Zamudio
authors.forename: Laura
authors.initials: L
authors.lastname: Cano Ortíz
authors.forename: Jeanet
authors.initials: J
authors.lastname: Serafín López
authors.forename: María Del Carmen
authors.initials: Mdel C
authors.lastname: Jiménez Martínez
authors.forename: Gustavo
authors.initials: G
authors.lastname: Aguilar Velázquez
authors.forename: Yonathan
authors.initials: Y
authors.lastname: Garfias Becerra
authors.forename: Concepción
authors.initials: C
authors.lastname: Santacruz Valdéz
authors.forename: Daniel
authors.initials: D
authors.lastname: Aguilar Ángeles
authors.forename: María Isabel
authors.initials: MI
authors.lastname: Rojo Guiérrez
authors.forename: Miguel
authors.initials: M
authors.lastname: Aguilar Santelises
authors.forename: Sergio
authors.initials: S
authors.lastname: Estrada Parra
mesh_terms: D015496:CD4-Positive T-Lymphocytes; D016207:Cytokines; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D007111:Immunity, Cellular; D050378:T-Lymphocytes, Regulatory; D018418:Th2 Cells; D014165:Transfer Factor
chemical_list: D016207:Cytokines; D014165:Transfer Factor