title: Small bowel lesions detected with wireless capsule endoscopy in patients with active ulcerative colitis and with post-proctocolectomy.
abstract: BACKGROUND
  Although rare, duodenal lesions have been reported in association with ulcerative colitis (UC); however, there have been very few reports on small bowel lesions, and many aspects of their pathology and frequency remain unknown. This study determined whether small bowel lesions are present in UC by using wireless capsule endoscopy (WCE).
  
  
  METHODS
  WCE was performed on 20 patients with active UC and 10 who had undergone proctocolectomy.
  
  
  RESULTS
  Small bowel lesions (e.g. edema or ulcers) were observed in 11 of the 30 patients (36.6%): in eight (40%) of the 20 patients with active UC and in three (33.3%) of the 10 post-proctocolectomy patients. Ulcers that extended over a long segment or whole tertile of the small bowel were observed in five patients, and the disease type was extensive colitis in three of these and pouchitis in the other two. Age at onset was significantly lower in the 20 active UC patients that had small bowel lesions.
  
  
  CONCLUSIONS
  WCE revealed the presence of ulcers that extended over a long segment or a whole tertile in the small bowel in active extensive colitis and pouchitis. In future, it will be necessary to assess the clinical significance of small bowel lesions in UC in detail.
authors.affiliation: Department of Gastroenterology, Fukuoka University Chikushi Hospital, 1-1-1 Zokumyoin, Chikushino, Fukuoka 818-8502, Japan. hisabe@cis.fukuoka-u.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Hisabe
authors.forename: Kazeo
authors.initials: K
authors.lastname: Ninomiya
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Matsui
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Karashima
authors.forename: Yuho
authors.initials: Y
authors.lastname: Sato
authors.forename: Takashi
authors.initials: T
authors.lastname: Nagahama
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Takaki
authors.forename: Fumihito
authors.initials: F
authors.lastname: Hirai
authors.forename: Kenshi
authors.initials: K
authors.lastname: Yao
authors.forename: Daijiro
authors.initials: D
authors.lastname: Higashi
authors.forename: Kitaro
authors.initials: K
authors.lastname: Futami
authors.forename: Akinori
authors.initials: A
authors.lastname: Iwashita
mesh_terms: D000328:Adult; D053704:Capsule Endoscopy; D016009:Chi-Square Distribution; D003093:Colitis, Ulcerative / Q000473:pathology* / Q000601:surgery; D004378:Duodenal Diseases / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007421:Intestine, Small / Q000473:pathology* / Q000601:surgery; D008297:Male; D019449:Pouchitis / Q000473:pathology* / Q000601:surgery; D016737:Proctocolectomy, Restorative; D018709:Statistics, Nonparametric