title: Dietary magnesium sulfate supplementation protects heat stress-induced oxidative damage by restoring the activities of anti-oxidative enzymes in broilers.
abstract: The purpose of this study was to investigate the effect of dietary magnesium sulfate supplementation on heat stress-induced oxidative damage in broilers. One hundred twenty 14-day-old broilers were randomly assigned into four treatment groups with three replicates of ten birds each. The broilers were reared under normal ambient temperature (24 ± 1°C) fed with a basal (control) diet or reared under high ambient temperature (35 ± 1°C between 1000 and 1800 h, 8 h each day) fed with a basal diet supplemented with magnesium sulfate (0, 2.5 or 5.0 mg/kg of diet) from 14 to 42 days of age. Growth performance and oxidative damage were evaluated in each treatment group. Our results demonstrated that dietary magnesium sulfate supplementation significantly prevented heat stress-induced oxidative damage and improved growth performance in broilers compared with that of control. Mechanistically, this beneficial effect was mediated, at least partly, by restoring the activity of anti-oxidative enzymes. This finding suggests that magnesium sulfate supplementation might be a potential strategy to attenuate heat stress-induced detrimental effects in broilers raised in summer season or tropical areas.
authors.affiliation: State key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yang
authors.forename: Mingyu
authors.initials: M
authors.lastname: Gao
authors.forename: Wei
authors.initials: W
authors.lastname: Nie
authors.forename: Jianmin
authors.initials: J
authors.lastname: Yuan
authors.forename: Bingkun
authors.initials: B
authors.lastname: Zhang
authors.forename: Zhong
authors.initials: Z
authors.lastname: Wang
authors.forename: Zhenlong
authors.initials: Z
authors.lastname: Wu
mesh_terms: D000821:Animal Feed; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002645:Chickens; D019587:Dietary Supplements; D018882:Heat Stress Disorders / Q000517:prevention & control / Q000662:veterinary*; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D018384:Oxidative Stress; D011201:Poultry Diseases / Q000517:prevention & control*
chemical_list: D000975:Antioxidants; D008278:Magnesium Sulfate; D007770:L-Lactate Dehydrogenase