title: Antiproliferative activity of xanthones isolated from Artocarpus obtusus.
abstract: An investigation of the chemical constituents in Artocarpus obtusus species led to the isolation of three new xanthones, pyranocycloartobiloxanthone A (1), dihydroartoindonesianin C (2), and pyranocycloartobiloxanthone B (3). The compounds were subjected to antiproliferative assay against human promyelocytic leukemia (HL60), human chronic myeloid leukemia (K562), and human estrogen receptor (ER+) positive breast cancer (MCF7) cell lines. Pyranocycloartobiloxanthone A (1) consistently showed strong cytotoxic activity against the three cell lines compared to the other two with IC(50) values of 0.5, 2.0 and 5.0 μg/mL, respectively. Compound (1) was also observed to exert antiproliferative activity and apoptotic promoter towards HL60 and MCF7 cell lines at respective IC(50) values. The compound (1) was not toxic towards normal cell lines human nontumorigenic breast cell line (MCF10A) and human peripheral blood mononuclear cells (PBMCs) with IC(50) values of more than 30 μg/mL.
authors.affiliation: Department of Chemistry, Universiti Putra Malaysia, Selangor, 43400 Serdang, Malaysia.
authors.forename: Najihah Mohd
authors.initials: NM
authors.lastname: Hashim
authors.forename: Mawardi
authors.initials: M
authors.lastname: Rahmani
authors.forename: Gwendoline Cheng Lian
authors.initials: GC
authors.lastname: Ee
authors.forename: Mohd Aspollah
authors.initials: MA
authors.lastname: Sukari
authors.forename: Maizatulakmal
authors.initials: M
authors.lastname: Yahayu
authors.forename: Winda
authors.initials: W
authors.lastname: Oktima
authors.forename: Abd Manaf
authors.initials: AM
authors.lastname: Ali
authors.forename: Rusea
authors.initials: R
authors.lastname: Go
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D031622:Artocarpus / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D051379:Mice; D011960:Receptors, Estrogen / Q000032:analysis; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D006576:Heterocyclic Compounds, 4 or More Rings; D011960:Receptors, Estrogen; D044004:Xanthones; C549170:dihydroartoindonesianin C; C549169:pyranocycloartobiloxanthone A; C569637:pyranocycloartobiloxanthone B