title: The 2,11-cyclized cembranoids: cladiellins, asbestinins, and briarellins (period 1998-2010).
abstract: The 2,11-cyclized cembranoids are isolated from marine invertebrates of Octocorallia species. They are a very interesting class of natural products sharing a common oxatricyclo[6.6.1.0(2,7)]pentadecane core and carrying a varied substituent pattern. This review presents their structural diversity along with the reported biological activities. The 2,11-cyclized cembranoids were comprehensively reviewed previously in 1998, and this contribution will serve as an update of that work. Since 1998 a number of structural assignments of the isolated products have been revised, some as a result of total synthesis efforts. The chemical reactivity of several of the natural compounds has been studied, and the relevance of these findings to the biosynthesis or the generation of isolation artifacts is discussed. The wide range of biological activities displayed by the 2,11-cyclized cembranoids justifies the interest shown within the synthetic chemistry community and suggests that this class of natural products remains a fruitful area for future synthetic and biological research.
authors.affiliation: Cancer Research UK Cancer Therapeutics Unit, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.
authors.forename: Amanda J
authors.initials: AJ
authors.lastname: Welford
authors.forename: Ian
authors.initials: I
authors.lastname: Collins
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004988:Ethers, Cyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008386:Marine Biology; D015394:Molecular Structure; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014363:Tryptamines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014439:Tyramine / Q000031:analogs & derivatives
chemical_list: C568804:2-bromo-N-methyltryptamine; C568805:3-bromo-N-methyltyramine; D004224:Diterpenes; D004988:Ethers, Cyclic; D013256:Steroids; D014363:Tryptamines; C475784:briarellin E; C506145:cladiellin A; D014439:Tyramine