title: Haemogram pattern at diagnosis of malignant disorders and variations post-chemotherapy.
abstract: A total of eighty patients with various malignancies seen between September 2008 and April 2009 at the University of Nigeria Teaching Hospital, (UNTH) Ituku-Ozalla Enugu Nigeria had their haemogram values done at Days 0 and 12 of the first cycle of their various chemotherapeutic regimens. They were adult patients who had been diagnosed of various malignancies, consisting of Breast cancer 36 patients (45%), Non-Hodgkin's iymphoma 8 (10%), Hodgkin's lymphoma 13 (16.25%), Colorectal carcinoma 6 (7.5%), Multiple myeloma 7 (8.75%), Cervical carcinoma 1 (1.25%) and other malignancies 9 (11.25%). Haematological indices evaluated include: packed cell volume, haemoglobin concentration; total white blood cell count, platelet count and erythrocyte sedimentation rate. The socio demographic data of the patients were assessed from a questionnaire. There were 27 males (33.75%) and 53 females (66.25%). The age of the patients ranged from 18-80 years with a median of 45 years. Haematological parameters which were found to be significantly reduced include: haemoglobin concentration, packed cell volume and total white cell count.
authors.affiliation: Department of Haematology & Immunology, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu State, Nigeria.
authors.forename: A J
authors.initials: AJ
authors.lastname: Madu
authors.forename: O G
authors.initials: OG
authors.lastname: Ibegbulam
authors.forename: S
authors.initials: S
authors.lastname: Ocheni
authors.forename: K A
authors.initials: KA
authors.lastname: Madu
authors.forename: E N
authors.initials: EN
authors.lastname: Aguwa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects*; D004906:Erythrocyte Count; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000187:drug effects*; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy; D009549:Nigeria; D010976:Platelet Count; D012016:Reference Values; D012959:Socioeconomic Factors; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D006454:Hemoglobins