title: ortho-Bromo(propa-1,2-dien-1-yl)arenes: substrates for domino reactions.
abstract: o-Bromo(propa-1,2-dien-1-yl)arenes exhibit novel and orthogonal reactivity under Pd catalysis in the presence of secondary amines to form enamines (concerted Pd insertion, intramolecular carbopalladation, and terminative Buchwald-Hartwig coupling) and of amides to form indoles (addition, Buchwald-Hartwig cyclization, and loss of the acetyl group). The substrates for these reactions can be accessed in a reliable and highly selective two-step process from 2-bromoaryl bromides.
authors.affiliation: Institut für Organische Chemie, Karlsruher Institut für Technologie, Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany.
authors.forename: Kye-Simeon
authors.initials: KS
authors.lastname: Masters
authors.forename: Manuela
authors.initials: M
authors.lastname: Wallesch
authors.forename: Stefan
authors.initials: S
authors.lastname: Bräse