title: [Heterogeneity of the rat respiratory way responses to serotonin].
abstract: In stimulation of preganglionic and postganglionic nervous fibres of the trachea and stimulation of preganglionic nervous fibres of the bronchi, serotonin strengthened reduction of a smooth muscle to 114 %. Methysergide (1.0 mkg) reduced responses to serotonin to 74-77 % on the trachea and practically didn't influence the bronchi. Against ketanserinum (1.0 mkg) serotonin is dose-dependent and reduced trachea's amplitude of the constriction to 60-63% and bronchi's amplitude of the constriction to 75-79%. Hexamethonium (100.0 mkg) reduced the serotonin amplitude of the constriction of the trachea at stimulation of postganglionic nerve to 64% and the bronchi at all kinds of irritation to 82-84%. Atropine (1.0 mkg) reduced effect of serotonin in stimulation of postganglionic nerve and tracheal smooth muscles to 75-77%. On preparations of bronchi, atropine reduced the serotonin effects in stimulation of preganglionic nervous fibres to 83% and strengthened to 117% in smooth muscles in stimulation of preganglionic nerve. Thus, there is heterogeneity of responses of smooth muscles of different sites of the tracheal-bronchial pathways of the rat to serotonin.
authors.forename: A N
authors.initials: AN
authors.lastname: Fedin
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Postnikova
authors.forename: V M
authors.initials: VM
authors.lastname: Kirilina
authors.forename: A I
authors.initials: AI
authors.lastname: Krivchenko
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001980:Bronchi / Q000187:drug effects* / Q000294:innervation / Q000502:physiology; D004558:Electric Stimulation; D018738:Hexamethonium / Q000494:pharmacology; D007537:Isometric Contraction / Q000187:drug effects*; D007650:Ketanserin / Q000494:pharmacology; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D009130:Muscle, Smooth / Q000187:drug effects* / Q000294:innervation / Q000502:physiology; D009412:Nerve Fibers / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000494:pharmacology; D046509:Tissue Culture Techniques; D014132:Trachea / Q000187:drug effects* / Q000294:innervation / Q000502:physiology
chemical_list: D012702:Serotonin Antagonists; D012701:Serotonin; D018738:Hexamethonium; D001285:Atropine; D007650:Ketanserin; D008784:Methysergide