title: Vaccines for colorectal cancer and renal cell carcinoma.
abstract: Vaccines have shown promise for the prevention and treatment of solid tumors. Colorectal cancer and renal cell carcinoma are common malignancies that may be amenable to vaccine strategies. This review summarizes target antigens in colorectal and renal cell carcinoma, discusses some of the vaccine approaches in development, and details the results of pivotal phase III trials evaluating therapeutic vaccines in patients with advanced colorectal and renal cell carcinoma. Finally, some of the challenges with vaccine development for colorectal and renal cell carcinoma are described.
authors.affiliation: Division of Hematology & Oncology and Rush University Cancer Center, Rush University Medical Center, Chicago, IL, USA.
authors.forename: Katherine
authors.initials: K
authors.lastname: Kabaker
authors.forename: Kathryn
authors.initials: K
authors.lastname: Shell
authors.forename: Howard L
authors.initials: HL
authors.lastname: Kaufman
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm; D019496:Cancer Vaccines / Q000276:immunology* / Q000627:therapeutic use*; D002272:Carcinoembryonic Antigen / Q000235:genetics / Q000276:immunology; D002292:Carcinoma, Renal Cell / Q000276:immunology* / Q000628:therapy*; D002986:Clinical Trials as Topic; D015179:Colorectal Neoplasms / Q000276:immunology* / Q000628:therapy*; D006801:Humans; D007680:Kidney Neoplasms / Q000276:immunology* / Q000628:therapy*; D051379:Mice; D008822:Mice, Transgenic; D018396:Mucin-1 / Q000276:immunology / Q000378:metabolism; D019444:Vaccines, DNA / Q000276:immunology
chemical_list: D000951:Antigens, Neoplasm; D019496:Cancer Vaccines; D002272:Carcinoembryonic Antigen; D018396:Mucin-1; D019444:Vaccines, DNA