title: Spirocyclic acylphloroglucinol derivatives from Hypericum beanii.
abstract: Four new acylphloroglucinols with an unusual 6/6/5 spirocyclic skeleton, hyperbeanols A-D (1-4), were isolated from the methanol extract of Hypericum beanii along with 16 known compounds. Their structures were established on the basis of spectroscopic and X-ray diffraction analysis. Hyperbeanols A-C were three stereoisomers different only at the relative configuration of C-4 and C-13, which were distinguished by the nuclear Overhauser effect spectroscopy (NOESY) spectroscopic data in combination with the single X-ray analysis of hyperbeanol A (1). The cytotoxic activity of hyperbeanols A-D against the cancer cell lines SK-BR-3, HL-60, SMMC-7721, PANC-1, MCF-7, and K562 was also evaluated.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kumning, Yunnan, People's Republic of China.
authors.forename: Xuan-Qin
authors.initials: XQ
authors.lastname: Chen
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Kun-Zhi
authors.initials: KZ
authors.lastname: Li
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Peng
authors.forename: Juan
authors.initials: J
authors.lastname: He
authors.forename: Kou
authors.initials: K
authors.lastname: Wang
authors.forename: Zheng-Hong
authors.initials: ZH
authors.lastname: Pan
authors.forename: Xiao
authors.initials: X
authors.lastname: Cheng
authors.forename: Ming-Ming
authors.initials: MM
authors.lastname: Li
authors.forename: Qin-Shi
authors.initials: QS
authors.lastname: Zhao
authors.forename: Gang
authors.initials: G
authors.lastname: Xu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D020902:Hypericum / Q000737:chemistry*; D015394:Molecular Structure; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D010696:Phloroglucinol