title: T2-weighted cardiac MR assessment of the myocardial area-at-risk and salvage area in acute reperfused myocardial infarction: comparison of state-of-the-art dark blood and bright blood T2-weighted sequences.
abstract: OBJECTIVE
  To compare different state-of-the-art T2-weighted (T2w) imaging sequences combined with late gadolinium enhancement (LGE) for myocardial salvage area (MSA) assessment by cardiac magnetic resonance (CMR). T2w imaging has been used to assess the myocardial area at risk (AAR) in acute myocardial infarction (AMI) patients, but its clinical application is challenging due to technical and physical limitations.
  
  
  METHODS
  Thirty patients with reperfused AMI underwent complete CMR imaging 2-5 days after hospital admission. Myocardial AAR and MSA were quantified on four different T2w sequences: (a) free-breathing T2-prepared single-shot balanced steady-state free precession (T2p_ssbSSFP); (b) breathhold T2-weighted acquisition for cardiac unified T2 edema (ACUTE); (c) breathhold T2w dark-blood inversion recovery turbo-spin echo (IR-TSE) (short-term inversion recovery: STIR); and (d) free-breathing high-resolution T2 dark-blood navigated BLADE. The diagnostic performance of each technique was also assessed.
  
  
  RESULTS
  Quantitative analysis showed significant differences in myocardial AAR extent as quantified by the four T2w sequences (P < 0.05). There were also significant differences in sensitivity, specificity and overall diagnostic performance.
  
  
  CONCLUSIONS
  Detection and quantification of AAR, and thus of MSA, by T2wCMR in reperfused AMI patients varied significantly between different T2w sequences in the same clinical setting.
authors.affiliation: Department of Radiology, University Hospital of Geneva, Geneva, Switzerland. magalie.viallon@hcuge.ch
authors.forename: Magalie
authors.initials: M
authors.lastname: Viallon
authors.forename: Nathan
authors.initials: N
authors.lastname: Mewton
authors.forename: Franck
authors.initials: F
authors.lastname: Thuny
authors.forename: Jens
authors.initials: J
authors.lastname: Guehring
authors.forename: Thomas
authors.initials: T
authors.lastname: O'Donnell
authors.forename: Alto
authors.initials: A
authors.lastname: Stemmer
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Bi
authors.forename: Stanislas
authors.initials: S
authors.lastname: Rapacchi
authors.forename: Sven
authors.initials: S
authors.lastname: Zuehlsdorff
authors.forename: Didier
authors.initials: D
authors.lastname: Revel
authors.forename: Pierre
authors.initials: P
authors.lastname: Croisille
mesh_terms: D000704:Analysis of Variance; D016009:Chi-Square Distribution; D003287:Contrast Media; D017023:Coronary Angiography; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008536:Meglumine; D008875:Middle Aged; D009203:Myocardial Infarction / Q000473:pathology* / Q000628:therapy; D015425:Myocardial Reperfusion; D009942:Organometallic Compounds; D012372:ROC Curve; D015203:Reproducibility of Results; D014672:Vectorcardiography
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D008536:Meglumine; C072417:gadoterate meglumine