title: Resuscitation in the delivery room: lung protection from the first breath.
abstract: Resuscitation of newborn infants occurs in approximately 10% of the more than 100 million infants born annually worldwide. The techniques used during resuscitation, such as positive-pressure ventilation and supplemental oxygen, may revive many infants, but have the potential to harm  their lungs. In recent years increasing attention has been applied to providing lung protection from the first breath. This paper reviews the currently available medical evidence concerning modifying aspects of delivery room management that are thought to mitigate lung injury. These include:  F(IO(2)) < 1.0; early use of continuous positive airway pressure (CPAP) and PEEP; optimizing pressure and/or volume during ventilation; sustained inflations; need for and timing of surfactant therapy; and airway management of meconium-stained amniotic fluid. Although the  evidence against 100% oxygen use is of low quality, it has been enough to alter the recommendations for oxygen use in the delivery room. It is suggested (not mandated) to use room air initially when resuscitating a term-gestation infant, and to use F(IO(2)) < 1.0 in premature  infants, with F(IO(2)) adjustments depending on oximetry values. Recent studies have not indicated better outcomes in premature infants in whom CPAP or PEEP is applied in the delivery room. Optimal peak ventilatory pressure and tidal volume have yet to be delineated. Although  an intriguing therapy, sustained inflations have not been shown to markedly improve outcomes. Prophylactic use of surfactant in small, premature infants remains the accepted standard. Immediate placement on CPAP after surfactant instillation has yet to demonstrate clear-cut advantages. Finally,  intrapartum oropharyngeal and nasopharyngeal suctioning of meconium-stained amniotic fluid does not improve outcomes in meconium-stained infants. Moreover, routine intubation and intratracheal suctioning of apparently vigorous meconium-stained infants do not improve outcomes. In summary, although  multiple therapies are touted as protecting the lungs in the delivery room "from the first breath," to date there are scant supportive data.
authors.affiliation: Center for Neonatal Care and the Department of Neonatology, Florida Hospital for Children, Orlando, Florida 32804, USA. thomas_wiswell@yahoo.com
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Wiswell
mesh_terms: D045422:Continuous Positive Airway Pressure; D003696:Delivery Rooms; D005260:Female; D005333:Fetus / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology; D007745:Labor Onset / Q000502:physiology; D010102:Oxygen Inhalation Therapy; D011175:Positive-Pressure Respiration; D011247:Pregnancy; D011663:Pulmonary Surfactants / Q000008:administration & dosage; D012121:Respiration, Artificial; D012151:Resuscitation / Q000379:methods
chemical_list: D011663:Pulmonary Surfactants