title: Sesquiterpenoids and norterpenoids from Vitex negundo.
abstract: Chemical investigation on the seeds of Vitex negundo has afforded a new furan-containing sesquiterpenoid, negunfurol (1), a new norlabdane-type diterpenoid, negundoal (2), and two new norursane-type triterpenoids, negundonorins A (3) and B (4), together with two know compounds, 3-formyl-4,5-dimethyl-8-oxo-5H-6,7-dihydronaphtho[2,3-b]furan (5) and 3-epi-corosolic acid (6). Their structures and configurations were elucidated by detailed spectroscopic analyses on the basis of NMR, IR, and MS data. Compound 3 was strongly cytotoxic against ZR-75-30 cell line with IC(50) value of 0.56 ± 0.19 μg/mL, whereas compound 1 was most active against HL-60 cell line with IC(50) value of 0.94 ± 0.26 μg/mL.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, PR China.
authors.forename: Cheng-Jian
authors.initials: CJ
authors.lastname: Zheng
authors.forename: Jiang
authors.initials: J
authors.lastname: Pu
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Ting
authors.initials: T
authors.lastname: Han
authors.forename: Khalid
authors.initials: K
authors.lastname: Rahman
authors.forename: Lu-Ping
authors.initials: LP
authors.lastname: Qin
mesh_terms: D015394:Molecular Structure; D013729:Terpenes / Q000737:chemistry*; D020950:Vitex / Q000737:chemistry*
chemical_list: D013729:Terpenes