title: Aurora promotes cell division during recovery from TOR-mediated cell cycle arrest by driving spindle pole body recruitment of Polo.
abstract: The coordination of cell division and growth in response to changes in nutrient supply is mediated by TOR signalling. In fission yeast, increased nutrient provision transiently delays mitotic onset without affecting growth. The result is an increase in cell size at division. We find that this block to cell division relies upon TOR and MAPK signalling and that mitotic entry during recovery from this block is regulated by the Aurora kinase Ark1. We show that Ark1 phosphorylation of polo kinase Plo1 within the linker region between the kinase domain and polo boxes drives Plo1 onto the spindle poles where it promotes mitosis. Interestingly, the use of Ark1 to phosphorylate Plo1 and promote mitotic entry is dependent on the environment.
authors.affiliation: University of Manchester, C.4255 Michael Smith Building, Faculty of Life Sciences, Oxford Road, Manchester M13 9PT,  UK.
authors.forename: Lenka
authors.initials: L
authors.lastname: Hálová
authors.forename: Janni
authors.initials: J
authors.lastname: Petersen
mesh_terms: D020816:Amino Acid Motifs / Q000235:genetics; D000818:Animals; D064127:Aurora Kinases; D059447:Cell Cycle Checkpoints; D002455:Cell Division; D048708:Cell Growth Processes; D017124:Conserved Sequence / Q000235:genetics; D019143:Evolution, Molecular; D006801:Humans; D020935:MAP Kinase Signaling System; D008938:Mitosis; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*; D021381:Protein Transport; D012568:Schizosaccharomyces / Q000502:physiology*; D029702:Schizosaccharomyces pombe Proteins / Q000235:genetics / Q000378:metabolism*; D008941:Spindle Apparatus / Q000378:metabolism*; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*; D014981:Xenopus
chemical_list: D029702:Schizosaccharomyces pombe Proteins; D064127:Aurora Kinases; C501407:Plo1 protein, S pombe; D017346:Protein Serine-Threonine Kinases; D058570:TOR Serine-Threonine Kinases; C576962:ark1 protein, S pombe