title: Moving out: from sterol transport to drug resistance - the ABCG subfamily of efflux pumps.
abstract: The ATP binding cassette (ABC) proteins are typically ATP-driven transmembrane pumps that have been evolutionarily conserved from bacteria to humans. In humans these transporters are subdivided into seven subfamilies, ranging from A to G. The ABCG subfamily of transporters is the primary focus of this review. This subfamily of proteins has been conserved throughout evolution and plays a central role in several cellular processes, such as sterol homeostasis and multidrug resistance. Functional polymorphisms/mutations in some of these G-subfamily transporters have clinical consequences in humans.
authors.affiliation: National Cancer Institute, Frederick, MD, USA. moitrak@mail.nih.gov
authors.forename: Karobi
authors.initials: K
authors.lastname: Moitra
authors.forename: Latoya
authors.initials: L
authors.lastname: Silverton
authors.forename: Katy
authors.initials: K
authors.lastname: Limpert
authors.forename: Kate
authors.initials: K
authors.lastname: Im
authors.forename: Michael
authors.initials: M
authors.lastname: Dean
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D000818:Animals; D001692:Biological Transport; D018432:Drug Resistance, Multiple; D019143:Evolution, Molecular; D006801:Humans; D013261:Sterols / Q000378:metabolism*
chemical_list: D018528:ATP-Binding Cassette Transporters; D013261:Sterols