title: Chronic bilateral subthalamic stimulation after anterior callosotomy in drug-resistant epilepsy: long-term clinical and functional outcome of two cases.
abstract: We explored the efficacy and safety of bilateral SubThalamic Nucleus (STN) stimulation in two subjects suffering from drug-resistant epilepsy even after anterior callosotomy. Case 1 had about 65% decrease of partial motor seizures and the complete disappearance of tonic-clonic generalized attacks. Case 2, with sudden drop (atonic) attacks, partial complex seizures, atypical absences and rare tonic-clonic seizures, showed no meaningful reduction of fits and a stimulation associated atypical absence rate increase.
authors.affiliation: Neuroscience Department, Politecnica delle Marche University, Azienda Ospedali Riuniti di Ancona, Italy. m.capecci@univpm.it
authors.forename: Marianna
authors.initials: M
authors.lastname: Capecci
authors.forename: Riccardo A
authors.initials: RA
authors.lastname: Ricciuti
authors.forename: Andrea
authors.initials: A
authors.lastname: Ortenzi
authors.forename: Aldo
authors.initials: A
authors.lastname: Paggi
authors.forename: Vasco
authors.initials: V
authors.lastname: Durazzi
authors.forename: Franco
authors.initials: F
authors.lastname: Rychlicki
authors.forename: Leandro
authors.initials: L
authors.lastname: Provinciali
authors.forename: Massimo
authors.initials: M
authors.lastname: Scerrati
authors.forename: Maria Gabriella
authors.initials: MG
authors.lastname: Ceravolo
mesh_terms: D000328:Adult; D003337:Corpus Callosum / Q000601:surgery*; D046690:Deep Brain Stimulation / Q000379:methods*; D004827:Epilepsy / Q000628:therapy*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D011612:Psychosurgery / Q000379:methods*; D020531:Subthalamic Nucleus / Q000502:physiology*; D016896:Treatment Outcome