title: High levels of serum uric acid impair development of coronary collaterals in patients with acute coronary syndrome.
abstract: We evaluated the association of serum uric acid (SUA) level and development of coronary collateral vessels (CCVs) in patients with acute coronary syndrome (ACS). Patients (n = 224) with ACS were included in the study. Coronary collateral vessels were graded according to the Rentrop scoring system. Rentrop grade 0 was accepted as absence of CCV (group 1; n = 117) and Rentrop grade ≥1 was accepted as presence of CCV (group 2; n = 107). Rentrop 0-1 (poor CCV) were determined in 167 patients and Rentrop 2-3 (good CCV) were determined in 57 patients. Both presence of CCV (P < .001) and development of good CCV (P = .003) were significantly associated with low levels of SUA. We suggest that high levels of SUA affect the CCV development negatively in nondiabetic and nonhypertensive patients with ACS.
authors.affiliation: Department of Cardiology, Etlik Ihtisas Research and Education Hospital, Ankara, Turkey. mduran2@gmail.com
authors.forename: Mustafa
authors.initials: M
authors.lastname: Duran
authors.forename: Ender
authors.initials: E
authors.lastname: Ornek
authors.forename: Sani N
authors.initials: SN
authors.lastname: Murat
authors.forename: Murat
authors.initials: M
authors.lastname: Turfan
authors.forename: Mehmet A
authors.initials: MA
authors.lastname: Vatankulu
authors.forename: Ayse
authors.initials: A
authors.lastname: Ocak
authors.forename: Cihan
authors.initials: C
authors.lastname: Doger
authors.forename: Ahmet A
authors.initials: AA
authors.lastname: Yalcin
authors.forename: Muhammed B
authors.initials: MB
authors.lastname: Demircelik
mesh_terms: D054058:Acute Coronary Syndrome / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D003097:Collateral Circulation; D017023:Coronary Angiography; D003326:Coronary Circulation; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D033461:Hyperuricemia / Q000097:blood* / Q000150:complications; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D014527:Uric Acid