title: ICSH recommendations for the measurement of haemoglobin A2.
abstract: Although DNA analysis is needed for characterization of the mutations that cause β-thalassaemia, measurement of the Hb A(2)  is essential for the routine identification of people who are carriers of β-thalassaemia. The methods of quantitating Hb A(2)  are described together with pitfalls in undertaking these laboratory tests with particular emphasis on automated high-performance liquid chromatography and capillary electrophoresis.
authors.affiliation: Department of Haematology, University College London Hospitals, London, UK. adrian.stephens@mac.com
authors.forename: A D
authors.initials: AD
authors.lastname: Stephens
authors.forename: M
authors.initials: M
authors.lastname: Angastiniotis
authors.forename: E
authors.initials: E
authors.lastname: Baysal
authors.forename: V
authors.initials: V
authors.lastname: Chan
authors.forename: S
authors.initials: S
authors.lastname: Fucharoen
authors.forename: P C
authors.initials: PC
authors.lastname: Giordano
authors.forename: J D
authors.initials: JD
authors.lastname: Hoyer
authors.forename: A
authors.initials: A
authors.lastname: Mosca
authors.forename: B
authors.initials: B
authors.lastname: Wild
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods; D019075:Electrophoresis, Capillary; D006443:Hemoglobin A2 / Q000032:analysis*; D006579:Heterozygote; D006801:Humans; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013048:Specimen Handling / Q000379:methods; D009626:Terminology as Topic; D017086:beta-Thalassemia / Q000175:diagnosis* / Q000235:genetics
chemical_list: D006443:Hemoglobin A2