title: Structural MRI reveals cortical thinning in amyotrophic lateral sclerosis.
abstract: OBJECTIVE
  Amyotrophic lateral sclerosis (ALS) is a fatal disease characterised by combined upper and lower motor neuron degeneration. An early and accurate diagnosis is important for patient care and might facilitate the search for a more effective therapy. MRI was used to study the whole cortical mantle, applying an unbiased surface based approach to identify a marker of upper motor neuron involvement in ALS.
  
  
  METHODS
  Surface based cortical morphology analyses were performed on structural, 3T MRI data of 45 patients with ALS and 25 matched healthy controls in a case control study design. These analyses consisted of measuring cortical thickness, surface area and volume. The effects of disease progression were examined by correlating cortical measures with progression rate and by longitudinal measures in 20 patients.
  
  
  RESULTS
  Cortical morphology analyses revealed specific thinning in the precentral gyrus, considered the primary motor cortex, in patients with ALS compared with controls (p=6.3×10(-8)). Surface area was reduced in the right inferior parietal region (p=0.049) and volume--the product of cortical thickness and surface area--was reduced in the right precentral gyrus (p=0.031). From these findings, it appears that cortical thickness is superior in detecting the degenerative effects of ALS. Relative cortical thinning in temporal regions was related to faster clinical progression (right inferior temporal gyrus: p=3.3×10(-4)).
  
  
  CONCLUSIONS
  Cortical thinning of the primary motor cortex might be a diagnostic marker for upper motor neuron degeneration in ALS. Relative thinning in temporal regions was associated with a rapidly progressive disease course.
authors.affiliation: Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands.
authors.forename: Esther
authors.initials: E
authors.lastname: Verstraete
authors.forename: Jan H
authors.initials: JH
authors.lastname: Veldink
authors.forename: Jeroen
authors.initials: J
authors.lastname: Hendrikse
authors.forename: H Jurgen
authors.initials: HJ
authors.lastname: Schelhaas
authors.forename: Martijn P
authors.initials: MP
authors.lastname: van den Heuvel
authors.forename: Leonard H
authors.initials: LH
authors.lastname: van den Berg
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000453:epidemiology / Q000473:pathology*; D016022:Case-Control Studies; D015897:Comorbidity; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000473:pathology*; D016472:Motor Neuron Disease / Q000453:epidemiology / Q000473:pathology*; D010296:Parietal Lobe; D013702:Temporal Lobe