title: Chiral allene-containing phosphines in asymmetric catalysis.
abstract: We demonstrate that allenes, chiral 1,2-dienes, appended with basic functionality can serve as ligands for transition metals. We describe an allene-containing bisphosphine that, when coordinated to Rh(I), promotes the asymmetric addition of arylboronic acids to α-keto esters with high enantioselectivity. Solution and solid-state structural analysis reveals that one olefin of the allene can coordinate to transition metals, generating bi- and tridentate ligands.
authors.affiliation: Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75398-9038, United States.
authors.forename: Feng
authors.initials: F
authors.lastname: Cai
authors.forename: Xiaotao
authors.initials: X
authors.lastname: Pu
authors.forename: Xiangbing
authors.initials: X
authors.lastname: Qi
authors.forename: Vincent
authors.initials: V
authors.lastname: Lynch
authors.forename: Akella
authors.initials: A
authors.lastname: Radha
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Ready
mesh_terms: D000466:Alkadienes / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*
chemical_list: D000466:Alkadienes; D009942:Organometallic Compounds; D010720:Phosphines; D012238:Rhodium