title: Neurodevelopment of infants with prenatal exposure to polybrominated diphenyl ethers.
abstract: The study aimed to examine the impact of prenatal exposure to polybrominated diphenyl ethers (PBDEs) on infant neurodevelopment. PBDEs levels in 36 cord blood samples were analyzed with a high-resolution-gas-chromatograph/high-resolution-mass-spectrometer and infant neurodevelopment was assessed using the Bayley Scales of Infant and Toddler Development, Third Edition. The mean and median of Σ(11)PBDEs were 6.63 and 4.63 ng/g lipid, respectively. As compared to the lower PBDEs group (Σ(11)PBDEs < 4.63 ng/g lipid), the higher PBDEs group (Σ(11)PBDEs > 4.63 ng/g lipid) had a significantly higher actual odds ratio (OR = 1.13, p < 0.05) of the cognition score as well as a lower odds ratio (OR = 0.904, p < 0.01) of the adaptive behavior score, suggesting that prenatal PBDEs exposure may potentially affect infant neurodevelopment.
authors.affiliation: Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Yanpu Pingtung County, 907, Taiwan.
authors.forename: Cherng-Gueih
authors.initials: CG
authors.lastname: Shy
authors.forename: Huei-Lin
authors.initials: HL
authors.lastname: Huang
authors.forename: Gou-Ping
authors.initials: GP
authors.lastname: Chang-Chien
authors.forename: How-Ran
authors.initials: HR
authors.lastname: Chao
authors.forename: Tsui-Chun
authors.initials: TC
authors.lastname: Tsou
mesh_terms: D002657:Child Development / Q000187:drug effects*; D004781:Environmental Exposure / Q000032:analysis*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D008401:Gas Chromatography-Mass Spectrometry; D055768:Halogenated Diphenyl Ethers / Q000097:blood* / Q000633:toxicity; D006801:Humans; D007223:Infant; D016015:Logistic Models; D008895:Milk, Human / Q000737:chemistry; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D016017:Odds Ratio; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013624:Taiwan
chemical_list: D055768:Halogenated Diphenyl Ethers