title: Synthesis, characterization and antitumor activity of polymeric copper(II) complexes with thiosemicarbazones of 3-methyl-5-oxo-1-phenyl-3-pyrazolin-4-carboxaldehyde and 5-oxo-3-phenyl-3-pyrazolin-4-carboxaldehyde.
abstract: New polymeric copper(II) complexes with two tridentate ONS thiosemicarbazone ligands containing substituted pyrazolone moiety were synthesized and characterized by means of spectroscopic, electrochemical and crystallographic techniques. While both ligands exist as different tautomers in the solid state and DMSO-d(6) solution, Cu(II) ion coordinates the ligands from the same tautomeric form with square-pyramidal geometry around each Cu atom. In the crystal structures, the copper(II) complex cation forms polymeric chains {[Cu(L)Cl](+)}(n) with a bridging chlorine atom. One of the complexes was found to have a significantly higher cytotoxic potential in comparison with cisplatin in inhibition of several cell lines (HL60, REH, C6, L929 and B16). The results obtained on the basis of flow cytometry indicated that apoptosis could be possible mechanism of cell death.
authors.affiliation: Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, University of Novi Sad, Trg D.Obradovića 3, 21000 Novi Sad, Serbia. vukadin.leovac@dh.uns.ac.rs
authors.forename: Vukadin M
authors.initials: VM
authors.lastname: Leovac
authors.forename: Goran A
authors.initials: GA
authors.lastname: Bogdanović
authors.forename: Ljiljana S
authors.initials: LS
authors.lastname: Jovanović
authors.forename: Ljubinka
authors.initials: L
authors.lastname: Joksović
authors.forename: Violeta
authors.initials: V
authors.lastname: Marković
authors.forename: Milan D
authors.initials: MD
authors.lastname: Joksović
authors.forename: Sonja Misirlić
authors.initials: SM
authors.lastname: Denčić
authors.forename: Anđelka
authors.initials: A
authors.lastname: Isaković
authors.forename: Ivanka
authors.initials: I
authors.lastname: Marković
authors.forename: Frank W
authors.initials: FW
authors.lastname: Heinemann
authors.forename: Srećko
authors.initials: S
authors.lastname: Trifunović
authors.forename: Ivica
authors.initials: I
authors.lastname: Đalović
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D002453:Cell Cycle; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D006801:Humans; D051379:Mice; D008958:Models, Molecular; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011720:Pyrazoles / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013882:Thiosemicarbazones / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D011108:Polymers; D011720:Pyrazoles; D013882:Thiosemicarbazones