title: Association of mtDNA haplogroup F with healthy longevity in the female Chuang population, China.
abstract: Human longevity is a complex heritable genetic trait. Based on substantial evidence from model organisms, it is clear that mitochondria play a pivotal role in aging and lifespan. However, the effects that mitochondrial genome variations have upon longevity and longevity-related phenotypes in Chuang people in China have yet to be established. By genotyping 15 variants for 10 haplogroups in 738 Chuang subjects, including 367 long-lived individuals and 371 controls, we found that haplogroup F was significantly associated with longevity in females of Zhuang population of China (p=0.003, OR: 2.01, 95%CI: 1.263-3.197). Additionally, haplogroup F was related to higher HDL levels (p<0.05) in long-lived individuals. Further analysis suggests that the non-synonymous variant m.13928G>C in haplogroup F was also associated with longevity in female Zhuang Chinese which might account for the beneficial effect of F.
authors.affiliation: Genetics Department, National Institutes of Geriatrics, Beijing Hospital, Ministry of Health P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Feng
authors.forename: Jianyi
authors.initials: J
authors.lastname: Zhang
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.forename: Gang
authors.initials: G
authors.lastname: Wan
authors.forename: Keyan
authors.initials: K
authors.lastname: Qi
authors.forename: Chenguang
authors.initials: C
authors.lastname: Zheng
authors.forename: Zeping
authors.initials: Z
authors.lastname: Lv
authors.forename: Caiyou
authors.initials: C
authors.lastname: Hu
authors.forename: Yi
authors.initials: Y
authors.lastname: Zeng
authors.forename: Simon G
authors.initials: SG
authors.lastname: Gregory
authors.forename: Ze
authors.initials: Z
authors.lastname: Yang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics* / Q000502:physiology; D044466:Asian People / Q000235:genetics*; D002681:China / Q000453:epidemiology; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008136:Longevity / Q000235:genetics* / Q000502:physiology; D008875:Middle Aged; D010641:Phenotype; D010802:Phylogeny
chemical_list: D004272:DNA, Mitochondrial