title: [Correlation of CD82 and hTERT expressions and HPV infection with penile cancer].
abstract: OBJECTIVE
  To study the correlation of the expressions of CD82 and hTERT and HPV infection with the clinical pathological features of penile cancer and identify their prognostic significance in the lymphatic metastasis of the disease.
  
  
  METHODS
  A total of 44 patients underwent partial or radical penectomy and lymph node dissection. The expressions of CD82 and hTERT were determined by immunohistochemistry, and HPV infection was detected by PCR.
  
  
  RESULTS
  The positive rates of CD82, hTERT, and HPV DNA in penile carcinoma were 47.7%, 38.6% and 25.9%, respectively. The amplified HPV DNA was HPV-16. The pathological stage and hTERT expression were positively correlated with inguinal lymph node metastasis of penile cancer (P = 0.032, P = 0.041), and so was the pathological stage with the expression of CD82 (P = 0.045), but neither the pathological stage, nor the expression of CD82 or the positive rate of HPV DNA showed any correlation with lymph node metastasis (P = 0.627, P = 0.094, P = 0.633).
  
  
  CONCLUSIONS
  The pathological grade and hTERT expression are independent prognostic factors for lymph node metastasis in penile carcinoma. These features help the prognosis and identification of the patient at the risk of nodal metastasis.
authors.affiliation: Department of Urology, Key Laboratory of the Ministry of Education for Carcinogenesis and Translational Research, Beijing Cancer Hospital/ Beijing Institute for Cancer Prevention and Treatment, Peking University School of Oncology, Beijing 100142, China.
authors.forename: Jian-Po
authors.initials: JP
authors.lastname: Zhai
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.forename: Qi-Yan
authors.initials: QY
authors.lastname: Wang
authors.forename: Dong
authors.initials: D
authors.lastname: Wei
authors.forename: Ke-Xin
authors.initials: KX
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D006801:Humans; D051861:Kangai-1 Protein / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000378:metabolism*; D010412:Penile Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D019098:Telomerase / Q000378:metabolism*
chemical_list: D051861:Kangai-1 Protein; D019098:Telomerase