title: Effect of cinacalcet on bone mineral density of the radius in hemodialysis patients with secondary hyperparathyroidism.
abstract: OBJECTIVE
  Cinacalcet, an allosteric modulator of the calcium sensing receptor, effectively reduces serum parathyroid hormone (PTH) in patients with secondary hyperparathyroidism. It is not well known whether bone mineral density (BMD) of hemodialysis patients with secondary hyperparathyroidism is altered after cinacalcet treatment.
  
  
  METHODS
  The BMD in the distal 1/3 of the radius and in the ultradistal radius, which are enriched with cortical and cancellous bone, respectively, was examined by dual X-ray absorptiometry, 1 year prior to, at the start, and 1 year after cinacalcet treatment, in 61 patients.
  
  
  RESULTS
  The BMD of both the distal 1/3 and ultradistal radius decreased significantly in the year prior to cinacalcet treatment (p < 0.01). However, the BMD at either site did not change significantly in the year after cinacalcet treatment. The annual changes in the BMD of the distal 1/3 radius increased significantly from -0.023 ± 0.029 g/cm2/year to -0.002 ± 0.033 g/cm2/year, prior to and after cinacalcet treatment, respectively; however, the annual changes in the BMD of the ultradistal radius did not change significantly prior to and after cinacalcet treatment.
  
  
  CONCLUSIONS
  There was a significant association between cinacalcet treatment and reduction in BMD loss in patients with secondary hyperparathyroidism. Cortical bone, rather than cancellous bone, was particularly affected by cinacalcet treatment.
authors.affiliation: Department of Nephrology, Osaka City University Graduate School of Medicine, Japan. ish@med.osaka-cu.ac.jp
authors.forename: E
authors.initials: E
authors.lastname: Ishimura
authors.forename: S
authors.initials: S
authors.lastname: Okuno
authors.forename: N
authors.initials: N
authors.lastname: Tsuboniwa
authors.forename: M
authors.initials: M
authors.lastname: Ichii
authors.forename: K
authors.initials: K
authors.lastname: Yamakawa
authors.forename: T
authors.initials: T
authors.lastname: Yamakawa
authors.forename: S
authors.initials: S
authors.lastname: Shoji
authors.forename: Y
authors.initials: Y
authors.lastname: Nishizawa
authors.forename: M
authors.initials: M
authors.lastname: Inaba
mesh_terms: D015502:Absorptiometry, Photon; D000704:Analysis of Variance; D015519:Bone Density / Q000187:drug effects*; D000069449:Cinacalcet; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000188:drug therapy*; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009281:Naphthalenes / Q000627:therapeutic use*; D011884:Radius / Q000000981:diagnostic imaging; D006435:Renal Dialysis; D016896:Treatment Outcome
chemical_list: D009281:Naphthalenes; D000069449:Cinacalcet