title: Artificial metalloenzymes for olefin metathesis based on the biotin-(strept)avidin technology.
abstract: Incorporation of a biotinylated Hoveyda-Grubbs catalyst within (strept)avidin affords artificial metalloenzymes for the ring-closing metathesis of N-tosyl diallylamine in aqueous solution. Optimization of the performance can be achieved either by chemical or genetic means.
authors.affiliation: Department of Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland.
authors.forename: Cheikh
authors.initials: C
authors.lastname: Lo
authors.forename: Mark R
authors.initials: MR
authors.lastname: Ringenberg
authors.forename: David
authors.initials: D
authors.lastname: Gnandt
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Wilson
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Ward
mesh_terms: D000498:Allyl Compounds / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D001710:Biotin / Q000737:chemistry*; D019921:Biotinylation; D002384:Catalysis; D008667:Metalloproteins / Q000138:chemical synthesis*; D012428:Ruthenium / Q000737:chemistry*; D019809:Streptavidin / Q000737:chemistry*
chemical_list: D000498:Allyl Compounds; D000588:Amines; D008667:Metalloproteins; D001710:Biotin; D012428:Ruthenium; D019809:Streptavidin