title: Effect of surfactants on the characteristics of fluconazole niosomes for enhanced cutaneous delivery.
abstract: Fluconazole-loaded niosomes were prepared by the film hydration method with different surfactants (Span and Brij series) and characterized for various parameters. Results showed that niosomes composed of Span 40, Span 60, and Brij 72 were most stable with smaller size, i.e. 0.378 ± 0.022 μm, 0.343 ± 0.063 μm, and 0.287 ± 0.012 μm, respectively, along with higher entrapment efficiency (approx. > 41%). In vitro skin permeation and retention studies suggested that cutaneous accumulation was affected by surfactant property and vesicle size. Therefore the niosomes consisting of Span 40, Span 60, and Brij 72 surfactant are seemingly accumulated and form localized drug depots in the skin, thereby releasing the contents in a sustained manner and able to greatly enhance cutaneous retention of the drug.
authors.affiliation: Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences , Dr. H. S. Gour Viswavidyalaya, Sagar, India.
authors.forename: Madhu
authors.initials: M
authors.lastname: Gupta
authors.forename: Bhuvaneshwar
authors.initials: B
authors.lastname: Vaidya
authors.forename: Neeraj
authors.initials: N
authors.lastname: Mishra
authors.forename: Suresh P
authors.initials: SP
authors.lastname: Vyas
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002214:Capsules; D002784:Cholesterol / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D004356:Drug Storage; D015725:Fluconazole / Q000008:administration & dosage* / Q000378:metabolism*; D008081:Liposomes / Q000737:chemistry*; D010539:Permeability; D051381:Rats; D012867:Skin / Q000378:metabolism*; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D002214:Capsules; D008081:Liposomes; D013501:Surface-Active Agents; D015725:Fluconazole; D002784:Cholesterol