title: Design of interior-functionalized fully acetylated dendrimers for anticancer drug delivery.
abstract: In this study, dendrimers was synthesized by introducing functional groups into the interior pockets of fully acetylated dendrimers. NMR techniques including COSY and 2D-NOESY revealed the molecular structures of the synthesized dendrimers and the encapsulation of guest molecule such as methotrexate within their interior pockets. The synthesized polymeric nanocarriers showed much lower cytotoxicity on two cell lines than cationic dendrimers, and exhibited better performance than fully acetylated dendrimers in the sustained release of methotrexate. The results provided a new strategy in the design of non-toxic dendrimers with high performance in the delivery of anti-cancer drugs for clinical applications.
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei 230026, PR China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Hu
authors.forename: Yunzhang
authors.initials: Y
authors.lastname: Su
authors.forename: Hongfeng
authors.initials: H
authors.lastname: Zhang
authors.forename: Tongwen
authors.initials: T
authors.lastname: Xu
authors.forename: Yiyun
authors.initials: Y
authors.lastname: Cheng
mesh_terms: D000107:Acetylation / Q000187:drug effects; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008727:Methotrexate / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D050091:Dendrimers; D004337:Drug Carriers; C104700:PAMAM Starburst; D008727:Methotrexate