title: [Leishmania donovani: structural insignt in the recognition of C-methylated analogues of spermidine as natural polyamine].
abstract: The ability of alpha-, beta-, gamma- and omega-methylated spermidine analogues to restore the growth of L. donovani promastigotes that were depleted of putrescine and spermidine was investigated. Only beta-methylated spermidine, like natural spermidine was capable of restoring the growth of L. donovani, while the remaining three analogues turned out to be inactive. Considering that alpha-methylated spermidine is a functionally active spermidine surrogate both in vivo and in vitro, this analogue can be considered as an antidote in the host-parasite system, especially in cases where inhibitors of polyamine biosynthesis are used for the therapy of leishmaniasis.
authors.forename: S
authors.initials: S
authors.lastname: Mandal
authors.forename: M A
authors.initials: MA
authors.lastname: Khomutov
authors.forename: A P
authors.initials: AP
authors.lastname: Simonian
authors.forename: S N
authors.initials: SN
authors.lastname: Kochetkov
authors.forename: R
authors.initials: R
authors.lastname: Madhubala
mesh_terms: D015317:Biogenic Polyamines / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D007893:Leishmania donovani / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism*; D008745:Methylation; D013095:Spermidine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000737:chemistry / Q000494:pharmacology
chemical_list: D015317:Biogenic Polyamines; D014344:Trypanocidal Agents; D013095:Spermidine