title: Effect of raloxifene (a Selective Estrogen Receptor Modulator (SERM)) as coadjuvant to antidepressant treatment: a case report.
abstract: We report a case of a woman with a depressive disorder with partial response to antidepressant treatment. Raloxifene, a Selective Estrogen Receptor Modulator (SERM) was added to the treatment, the patient achieving complete remission of her depressive symptoms. The interest of our case lies in the fact that it exemplifies the relationship between depressive disorders and hormonal changes during menopause. Furthermore, raloxifene may become a novel therapeutic option in some postmenopausal women who do not respond or only partially respond to SSRIs, especially in those with a history of depressive disorders related to menopause.
authors.affiliation: Sant Joan de Déu-SSM, Fundació Sant Joan de Déu, Sant Boi, Barcelona. usall@sjd-ssm.com
authors.forename: Judith
authors.initials: J
authors.lastname: Usall
authors.forename: Marta
authors.initials: M
authors.lastname: Coromina
authors.forename: Susana
authors.initials: S
authors.lastname: Araya
authors.forename: Susana
authors.initials: S
authors.lastname: Ochoa
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008875:Middle Aged; D020849:Raloxifene Hydrochloride / Q000627:therapeutic use*; D020845:Selective Estrogen Receptor Modulators / Q000627:therapeutic use*
chemical_list: D000928:Antidepressive Agents; D020845:Selective Estrogen Receptor Modulators; D020849:Raloxifene Hydrochloride