title: Electrodiffusion model simulation of the potassium channel.
abstract: The drift-diffusion (Poisson-Nernst-Planck) model is applied to the potassium channel in a biological membrane plus surrounding solution baths. Two-dimensional cylindrically symmetric simulations of the K channel in KCl solutions are presented which show significant boundary layers at the ends of the channel and display the spreading of charge into the bath regions. The computed current-voltage curve shows excellent agreement with experimental measurements. In addition, the response of the K channel to time-dependent applied voltages is investigated.
authors.affiliation: School of Mathematical & Statistical Sciences, Arizona State University, Tempe AZ 85287, United States. gardner@math.asu.edu
authors.forename: Carl L
authors.initials: CL
authors.lastname: Gardner
authors.forename: Jeremiah R
authors.initials: JR
authors.lastname: Jones
mesh_terms: D000818:Animals; D004058:Diffusion; D004553:Electric Conductivity; D004558:Electric Stimulation; D015640:Ion Channel Gating / Q000502:physiology; D008954:Models, Biological; D015221:Potassium Channels / Q000502:physiology*; D011189:Potassium Chloride
chemical_list: D015221:Potassium Channels; D011189:Potassium Chloride