title: MOSFET assessment of radiation dose delivered to mice using the Small Animal Radiation Research Platform (SARRP).
abstract: The Small Animal Radiation Research Platform (SARRP) is a novel isocentric irradiation system that enables state-of-the-art image-guided radiotherapy research to be performed with animal models. This paper reports the results obtained from investigations assessing the radiation dose delivered by the SARRP to different anatomical target volumes in mice. Surgically implanted metal oxide semiconductor field effect transistors (MOSFET) dosimeters were employed for the dose assessment. The results reveal differences between the calculated and measured dose of -3.5 to 0.5%, -5.2 to -0.7%, -3.9 to 0.5%, -5.9 to 2.5%, -5.5 to 0.5%, and -4.3 to 0% for the left kidney, liver, pancreas, prostate, left lung, and brain, respectively. Overall, the findings show less than 6% difference between the delivered and calculated dose, without tissue heterogeneity corrections. These results provide a useful assessment of the need for tissue heterogeneity corrections in SARRP dose calculations for clinically relevant tumor model sites.
authors.affiliation: Department of Radiation Oncology, Division of Medical Physics and Biophysics, Brigham and Women's Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Wilfred
authors.initials: W
authors.lastname: Ngwa
authors.forename: Houari
authors.initials: H
authors.lastname: Korideck
authors.forename: Lee M
authors.initials: LM
authors.lastname: Chin
authors.forename: G Mike
authors.initials: GM
authors.lastname: Makrigiorgos
authors.forename: Ross I
authors.initials: RI
authors.lastname: Berbeco
mesh_terms: D000818:Animals; D054893:Cone-Beam Computed Tomography; D008297:Male; D051379:Mice; D010087:Oxides / Q000737:chemistry*; D011874:Radiometry / Q000295:instrumentation*; D014173:Transistors, Electronic
chemical_list: D010087:Oxides