title: A successful 4S heart transplantation.
abstract: Donor recipient matching is paramount to successful heart transplantation. The presence of allosensitization decreases the transplant candidate's donor pool, prolongs the time to transplantation, and increases the post-transplant mortality and morbidity. Various strategies are applied to reduce antibody loads with mixed results being reported. The development of a new listing criterion by the Canadian Cardiac Transplant Network (CCTN) for sensitized patients may overcome this problem by increasing the odds that a given recipient receives an organ from an appropriately matched donor. The success of this case gives hope to patients and provides insights into the treatment of sensitized patients.
authors.affiliation: Division of Cardiology Adult Heart Transplant Program, St Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Maha A
authors.initials: MA
authors.lastname: Al-Mohaissen
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Ignaszewski
authors.forename: Anson
authors.initials: A
authors.lastname: Cheung
authors.forename: Annemarie
authors.initials: A
authors.lastname: Kaan
authors.forename: Wynne
authors.initials: W
authors.lastname: Chiu
authors.forename: Jennifer
authors.initials: J
authors.lastname: Kealy
authors.forename: Sean A
authors.initials: SA
authors.lastname: Virani
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal; D046148:Donor Selection / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000517:prevention & control*; D006333:Heart Failure / Q000601:surgery*; D016027:Heart Transplantation / Q000379:methods*; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage; D007155:Immunologic Factors / Q000008:administration & dosage; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D010956:Plasmapheresis / Q000379:methods; D014019:Tissue Donors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors; D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid