title: [The target of Musca domestica cecropin on human hepatocellular carcinoma BEL-7402 cells].
abstract: Human hepatocellular carcinoma BEL-7402 cells were treated with 50 micromol/L Musca domestica cecropin for 12 h, and observed under scanning electron microscope. The effect of Musca domestica cecropin labeled with FITC (FITC-cecropin) on BEL-7402 cells was detected by laser scanning confocal microscopy. The scanning electron microscopy showed that most microvilli on the surface of BEL-7402 cells disappeared at 12 h after cecropin treatment. The laser scanning confocal microscopy revealed that most FITC-cecropin combined with BEL-7402 cell membrane, and partly in the cytoplasm.
authors.affiliation: School of Basic Courses, Guangdong Pharmaceutical University, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China.
authors.forename: Xiao-bao
authors.initials: XB
authors.lastname: Jin
authors.forename: Xiao-bo
authors.initials: XB
authors.lastname: Li
authors.forename: Jia-yong
authors.initials: JY
authors.lastname: Zhu
authors.forename: Xue-mei
authors.initials: XM
authors.lastname: Lu
authors.forename: Juan
authors.initials: J
authors.lastname: Shen
authors.forename: Fu-jiang
authors.initials: FJ
authors.lastname: Chu
authors.forename: Han-fang
authors.initials: HF
authors.lastname: Mei
mesh_terms: D000818:Animals; D054807:Cecropins / Q000494:pharmacology*; D045744:Cell Line, Tumor / Q000187:drug effects / Q000648:ultrastructure; D002462:Cell Membrane / Q000187:drug effects / Q000648:ultrastructure*; D006793:Houseflies / Q000737:chemistry*; D006801:Humans
chemical_list: D054807:Cecropins