title: Nucleoside-lipid-based nanoparticles for cisplatin delivery.
abstract: The use of delivery vehicles to selectively transport anticancer agents to tumors is very attractive to address both toxicity and efficacy issues. We report a novel approach based on hybrid nucleoside-lipids allowing the efficient encapsulation and delivery of cisplatin. We demonstrate that the nucleoside polar heads guide the self-assembly of the aggregates into highly loaded and stable nanoparticles. The nanoparticles, which are efficient vehicles for the delivery of cisplatin into different sensitive and resistant cancer cell lines, can overcome the disadvantages and limitations of drug delivery systems previously reported.
authors.affiliation: INSERM U869, Bordeaux F-33076, France.
authors.forename: Salim
authors.initials: S
authors.lastname: Khiati
authors.forename: Delphine
authors.initials: D
authors.lastname: Luvino
authors.forename: Khalid
authors.initials: K
authors.lastname: Oumzil
authors.forename: Bruno
authors.initials: B
authors.lastname: Chauffert
authors.forename: Michel
authors.initials: M
authors.lastname: Camplo
authors.forename: Philippe
authors.initials: P
authors.lastname: Barthélémy
mesh_terms: D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000378:metabolism / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology; D009705:Nucleosides / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008055:Lipids; D009705:Nucleosides; D002945:Cisplatin