title: Candida albicans infections in renal transplant recipients: effect of caspofungin on polymorphonuclear cells.
abstract: This study aimed to compare the caspofungin immunomodulating activities against Candida albicans on polymorphonuclear cells (PMNs) from renal transplant recipients (RTRs) and healthy subjects (HSs). RTR PMNs showed a significantly reduced fungicidal activity compared with that of HS PMNs. Addition of caspofungin to RTR PMNs significantly potentiated the yeast intracellular killing rate, achieving values similar to those observed for HS PMNs. These data show that caspofungin is suitable for invasive candidiasis treatment in patients with immune system-impaired components.
authors.affiliation: Department of Public Health and Microbiology, Microbiology Section, University of Turin, Via Santena 9, 10126 Turin, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Allizond
authors.forename: Giuliana
authors.initials: G
authors.lastname: Banche
authors.forename: Franca
authors.initials: F
authors.lastname: Giacchino
authors.forename: Chiara
authors.initials: C
authors.lastname: Merlino
authors.forename: Daniela
authors.initials: D
authors.lastname: Scalas
authors.forename: Vivian
authors.initials: V
authors.lastname: Tullio
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Garneri
authors.forename: Narcisa
authors.initials: N
authors.lastname: Mandras
authors.forename: Janira
authors.initials: J
authors.lastname: Roana
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Cuffini
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D002176:Candida albicans / Q000187:drug effects*; D058365:Candidiasis, Invasive / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D000077336:Caspofungin; D054714:Echinocandins / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D055666:Lipopeptides; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077336:Caspofungin