title: Association of caveolin-1 genotypes with nasopharyngeal carcinoma susceptibility in Taiwan.
abstract: BACKGROUND
  Caveolin-1 (Cav-1), which has been proposed as a candidate tumor suppressor, plays a regulatory role in several signaling pathways. High expression of Cav-1 in nasopharyngeal carcinoma (NPC) may enhance tumor cell migration and correlate with poor prognosis of the patients, while the genetic alterations of Cav-1 during nasopharyngeal carcinogenesis are still largely unknown. The aim of this study was to evaluate the association between NPC susceptibility and Cav-1 genotypes.
  
  
  METHODS
  One hundred and seventy six patients with NPC and 176 age- and gender-matched healthy controls recruited in Taiwan were genotyped and analyzed by PCR-restriction fragment length polymorphism.
  
  
  RESULTS
  There were significant differences between the NPC and control groups in the distributions of the genotypic (p=0.0019) and allelic frequencies (p=2.5 10(-4)) in the Cav-1 T29107A (rs7804372) polymorphism.
  
  
  CONCLUSIONS
  In this first report of Cav-1 involvement in NPC the A allele of Cav-1 T29107A is found to be protective against the development of NPC and may be a novel useful genomic marker for early screening and prediction of NPC.
authors.affiliation: Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, 2 Yuh-Der Road, Taichung, 404 Taiwan, R.O.C.
authors.forename: Yung-An
authors.initials: YA
authors.lastname: Tsou
authors.forename: Chia-Wen
authors.initials: CW
authors.lastname: Tsai
authors.forename: Ming-Hsui
authors.initials: MH
authors.lastname: Tsai
authors.forename: Wen-Shin
authors.initials: WS
authors.lastname: Chang
authors.forename: Fang-Jing
authors.initials: FJ
authors.lastname: Li
authors.forename: Yen-Fang
authors.initials: YF
authors.lastname: Liu
authors.forename: Chang-Fang
authors.initials: CF
authors.lastname: Chiu
authors.forename: Cheng-Chieh
authors.initials: CC
authors.lastname: Lin
authors.forename: Da-Tian
authors.initials: DT
authors.lastname: Bau
mesh_terms: D000483:Alleles; D002277:Carcinoma; D016022:Case-Control Studies; D051242:Caveolin 1 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000235:genetics*; D013624:Taiwan
chemical_list: C495540:CAV1 protein, human; D051242:Caveolin 1