title: Nanoparticle agglomerates of fluticasone propionate in combination with albuterol sulfate as dry powder aerosols.
abstract: Particle engineering strategies remain at the forefront of aerosol research for localized treatment of lung diseases and represent an alternative for systemic drug therapy. With the hastily growing popularity and complexity of inhalation therapy, there is a rising demand for tailor-made inhalable drug particles capable of affording the most proficient delivery to the lungs and the most advantageous therapeutic outcomes. To address this formulation demand, nanoparticle agglomeration was used to develop aerosols of the asthma therapeutics, fluticasone or albuterol. In addition, a combination aerosol was formed by drying agglomerates of fluticasone nanoparticles in the presence of albuterol in solution. Powders of the single drug nanoparticle agglomerates or of the combined therapeutics possessed desirable aerodynamic properties for inhalation. Powders were efficiently aerosolized (∼75% deposition determined by cascade impaction) with high fine particle fraction and rapid dissolution. Nanoparticle agglomeration offers a unique approach to obtain high performance aerosols from combinations of asthma therapeutics.
authors.affiliation: Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS 66047, United States.
authors.forename: Nashwa
authors.initials: N
authors.lastname: El-Gendy
authors.forename: Warangkana
authors.initials: W
authors.lastname: Pornputtapitak
authors.forename: Cory
authors.initials: C
authors.lastname: Berkland
mesh_terms: D000336:Aerosols; D000420:Albuterol / Q000008:administration & dosage* / Q000737:chemistry*; D000730:Androstadienes / Q000008:administration & dosage* / Q000737:chemistry*; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D011232:Chemical Precipitation; D003460:Crystallization; D004338:Drug Combinations; D058995:Dry Powder Inhalers; D000068298:Fluticasone; D007930:Leucine / Q000737:chemistry; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D033362:Powder Diffraction; D011208:Powders; D012212:Rheology; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D013016:Sound; D013501:Surface-Active Agents / Q000737:chemistry; D013816:Thermodynamics; D013818:Thermogravimetry; D044366:Transition Temperature; D014961:X-Ray Diffraction
chemical_list: D000336:Aerosols; D000730:Androstadienes; D001993:Bronchodilator Agents; D004338:Drug Combinations; D011208:Powders; D012997:Solvents; D013501:Surface-Active Agents; D000068298:Fluticasone; D007930:Leucine; D000420:Albuterol