title: Cardioprotective effects of an aminothiazole compound on isoproterenol-induced myocardial injury in mice.
abstract: Dendrodoine analogue (DA), an aminothiazole compound derived from dendrodoine, present in a marine tunicate, has been shown to possess many beneficial properties. This study was aimed to evaluate its cardioprotective effect against isoproterenol (ISO)-induced myocardial damage in mice. Swiss mice were pretreated with DA for 7 days and then treated with ISO (5 mg/kg BW, for 2 consecutive days). Biochemical assessment of myocardial injury was carried out by measuring marker enzymes, antioxidant enzymes and levels of lipid peroxidation. Histological studies of hearts were also carried out. ISO administration increased the activities of creatine kinase-MB, lactate dehydrogenase and aspartate aminotranferase (AST) in serum. Prior administration of DA restored the levels of these enzymes and the heart coefficient close to normal levels. DA at a concentration of 5 mg/kg BW was most effective in reducing AST, and this concentration was used for further studies. DA also gave significant protection against lipid peroxidation in the heart besides restoring histopathological alterations. DA showed significant reactivity towards superoxide radicals. In conclusion our study indicates that DA can protect mouse myocardium against damage and one of the possible reasons behind this protective effect can be attributed to its antioxidant property.
authors.affiliation: Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400 085, India.
authors.forename: Strayo
authors.initials: S
authors.lastname: De
authors.forename: S
authors.initials: S
authors.lastname: Adhikari
authors.forename: Thomas P A
authors.initials: TP
authors.lastname: Devasagayam
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D002316:Cardiotonic Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006335:Heart Injuries / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D007211:Indoles / Q000494:pharmacology*; D007545:Isoproterenol / Q000009:adverse effects*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism; D016019:Survival Analysis; D013830:Thiadiazoles / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D002316:Cardiotonic Agents; D007211:Indoles; D011943:Receptors, Adrenergic, beta; D013830:Thiadiazoles; D013481:Superoxides; C054959:dendrodoine; D007545:Isoproterenol