title: [Relationship of TLR2 and TLR4 gene polymorphism with a penchant for individual urogenital infections].
abstract: We investigated the population prevalence of polymorphisms of Arg753Gln TLR2gene, and Asp299Gly, Thr399Ile TLR4 genes among people living in the Poltava region, as well as data communication polymorphisms with the presence of diseases caused by urogenital infections. The group of population control was a random sample of residents of the Poltava region (n = 299). The group of patients with urogenital diseases included 156 people. Genotyping of these groups TLR2 Arg753Gln polymorphism and the gene TLR4 Asp299Gly, Thr399Ile was performed using PCR and subsequent restriction analysis. Statistically significant association of allele A ofgene TLR2 (p = 0.0018) and allele G of gene TLR4 (p = 0.085) with the presence of urogenital diseases was confirmed.
authors.forename: O V
authors.initials: OV
authors.lastname: Izmaĭlova
authors.forename: O A
authors.initials: OA
authors.lastname: Shlykova
authors.forename: N O
authors.initials: NO
authors.lastname: Bobrova
authors.forename: I P
authors.initials: IP
authors.lastname: Kaĭdashev
mesh_terms: D000328:Adult; D001424:Bacterial Infections / Q000453:epidemiology / Q000235:genetics* / Q000382:microbiology; D016022:Case-Control Studies; D002689:Chlamydia / Q000254:growth & development; D002690:Chlamydia Infections / Q000453:epidemiology / Q000235:genetics* / Q000382:microbiology; D003430:Cross-Sectional Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006090:Gram-Negative Bacteria / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000254:growth & development; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011159:Population Surveillance / Q000379:methods*; D015183:Restriction Mapping; D012307:Risk Factors; D051195:Toll-Like Receptor 2 / Q000737:chemistry / Q000235:genetics; D051197:Toll-Like Receptor 4 / Q000737:chemistry / Q000235:genetics; D014455:Ukraine; D014566:Urogenital System / Q000378:metabolism / Q000382:microbiology*
chemical_list: C495342:TLR2 protein, human; C495345:TLR4 protein, human; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4