title: Structural basis of cross-allele presentation by HLA-A*0301 and HLA-A*1101 revealed by two HIV-derived peptide complexes.
abstract: Human leukocyte antigens (HLA) are initially classified by serotyping but recently can be re-grouped by their peptide-presentation characteristics into supertypes. Both HLA-A*0301 and HLA-A*1101 are grouped into A3 supertype. Although a number of cross-presented T cell epitopes of HLA-A*0301 and HLA-A*1101 have been identified, the molecular mechanisms of cross-presentation remain elusive. Herein, the structures of HLA-A*0301 with two HIV-derived immunodominant T cell epitopes were solved and their characteristics in comparison with HLA-A*1101 presenting the same peptides were analyzed. The comparable structures of HLA-A*0301 and HLA-A*1101 with subtle differences illustrate the common modes of cross-presented peptides and the strict HLA-restriction of T cell receptor (TCR)-recognition.
authors.affiliation: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
authors.forename: Shihong
authors.initials: S
authors.lastname: Zhang
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Hao
authors.initials: H
authors.lastname: Cheng
authors.forename: Shuguang
authors.initials: S
authors.lastname: Tan
authors.forename: Jianxun
authors.initials: J
authors.lastname: Qi
authors.forename: Jinghua
authors.initials: J
authors.lastname: Yan
authors.forename: George F
authors.initials: GF
authors.lastname: Gao
mesh_terms: D017951:Antigen Presentation / Q000276:immunology*; D045142:Cross-Priming / Q000276:immunology*; D018984:Epitopes, T-Lymphocyte / Q000276:immunology; D059870:HLA-A11 Antigen / Q000737:chemistry* / Q000276:immunology; D015791:HLA-A3 Antigen / Q000737:chemistry* / Q000276:immunology; D054298:Human Immunodeficiency Virus Proteins / Q000276:immunology; D006801:Humans; D008958:Models, Molecular; D010455:Peptides / Q000276:immunology; D011487:Protein Conformation; D011948:Receptors, Antigen, T-Cell / Q000276:immunology
chemical_list: D018984:Epitopes, T-Lymphocyte; C442141:HLA-A*03:01 antigen; C515740:HLA-A*11:01 antigen; D059870:HLA-A11 Antigen; D015791:HLA-A3 Antigen; D054298:Human Immunodeficiency Virus Proteins; D010455:Peptides; D011948:Receptors, Antigen, T-Cell