title: Single nucleotide polymorphisms in CAPN and leptin genes associated with meat color and tenderness in Nellore cattle.
abstract: We analyzed single nucleotide polymorphisms in  calpain, leptin, leptin receptor, and growth hormone receptor genes and their  association with color, drip and cooking losses of longissimus muscle at 7, 14  and 21 days postmortem in 638 purebred Nellore bulls slaughtered between 22 and  26 months of age. Meat samples were vacuum-packed and aged at 4°C. The single  nucleotide polymorphisms T945M, GHR2, E2FB, and CAPN4751 were evaluated. All  genotypic classes were observed; however, the T/T genotype of T945M and E2FB  was found at a low frequency. A significant association of E2FB with drip loss  (a measure of water-holding capacity) was detected at seven days of meat aging.  CAPN4751 had an additive effect on red and yellow color intensities. The T  allele of CAPN4751 was found to be positively associated with improved meat  color, but not with meat tenderness, differing from a previous report  indicating that it is associated with meat tenderness. We conclude that the  potential for use of CAPN4751 as a marker for these meat quality traits  requires further research.
authors.affiliation: Departamento de Produção Animal, Escola de Medicina Veterinária e Zootecnia, Universidade Federal da Bahia, Salvador, BA, Brasil.
authors.forename: L F B
authors.initials: LF
authors.lastname: Pinto
authors.forename: J B S
authors.initials: JB
authors.lastname: Ferraz
authors.forename: V B
authors.initials: VB
authors.lastname: Pedrosa
authors.forename: J P
authors.initials: JP
authors.lastname: Eler
authors.forename: F V
authors.initials: FV
authors.lastname: Meirelles
authors.forename: M N
authors.initials: MN
authors.lastname: Bonin
authors.forename: F M
authors.initials: FM
authors.lastname: Rezende
authors.forename: M E
authors.initials: ME
authors.lastname: Carvalho
authors.forename: D C
authors.initials: DC
authors.lastname: Cucco
authors.forename: R C G
authors.initials: RC
authors.lastname: Silva
mesh_terms: D000818:Animals; D001823:Body Composition / Q000235:genetics*; D002154:Calpain / Q000235:genetics*; D002417:Cattle / Q000235:genetics*; D004247:DNA / Q000032:analysis / Q000235:genetics; D005819:Genetic Markers; D005838:Genotype; D020738:Leptin / Q000235:genetics*; D058751:Livestock / Q000235:genetics; D008460:Meat / Q000032:analysis; D018482:Muscle, Skeletal; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D054411:Receptors, Leptin / Q000235:genetics; D011986:Receptors, Somatotropin / Q000235:genetics
chemical_list: D005819:Genetic Markers; D020738:Leptin; D054411:Receptors, Leptin; D011986:Receptors, Somatotropin; D004247:DNA; D002154:Calpain; C484807:CAPN1 protein, Bos taurus