title: Prognostic factors and outcomes in 28 cases of uterine leiomyosarcoma.
abstract: OBJECTIVE
  It was the aim of this study to evaluate clinicopathological characteristics and prognostic factors of uterine leiomyosarcomas (LMS).
  
  
  METHODS
  Twenty-eight patients with uterine LMS were evaluated in this retrospective study. Their features and survival were analyzed by Kaplan-Meier and log-rank tests.
  
  
  RESULTS
  The median age of the patients was 52 years (range 25-74). Nine patients had a disease with a mitotic count <10/10 high-power fields. Twenty-one patients presented with stage I disease, 1 with stage II and 6 with stage IV. Twelve patients underwent total hysterectomy and bilateral salpingo-oophorectomy, 2 simple hysterectomy, 5 myomectomy and 9 more comprehensive surgical treatments. Adjuvant chemotherapy was administered to 16 patients, whereas chemoradiation was given only to 2 patients. Fifty percent presented with recurrence of the disease. The median overall survival was 46 months. Age, mitotic count, type of surgery, adjuvant therapy, recurrence and clinical response to chemotherapy were not found to affect survival, while the menopausal status and FIGO (International Federation of Gynecology and Obstetrics) stage were found to be prognostic factors.
  
  
  CONCLUSIONS
  In our series, the menopausal state and FIGO stage were found to be prognostic factors related to survival.
authors.affiliation: Department of Gynecology, Obstetrics and Neonatology, University of Bari, Bari, Italy. vloizzi@tiscali.it
authors.forename: V
authors.initials: V
authors.lastname: Loizzi
authors.forename: G
authors.initials: G
authors.lastname: Cormio
authors.forename: D
authors.initials: D
authors.lastname: Nestola
authors.forename: M
authors.initials: M
authors.lastname: Falagario
authors.forename: A
authors.initials: A
authors.lastname: Surgo
authors.forename: A
authors.initials: A
authors.lastname: Camporeale
authors.forename: G
authors.initials: G
authors.lastname: Putignano
authors.forename: L
authors.initials: L
authors.lastname: Selvaggi
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000628:therapy; D009367:Neoplasm Staging; D011379:Prognosis; D011960:Receptors, Estrogen / Q000032:analysis; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy
chemical_list: D011960:Receptors, Estrogen