title: Ultra-sensitive microfibre absorption detection in a microfluidic chip.
abstract: We report a microfibre absorption sensor by using a 900 nm diameter silica microfibre embedded in a 125 μm wide microchannel with a detection length of 2.5 cm. Investigated by measuring the absorbance of methylene blue (MB), the sensor shows a detection limit down to 50 pM with excellent reversibility in a concentration range of 0-5 nM. The sensor has also been applied to bovine serum albumin (BSA) measurement, with a detection limit of 10 fg mL(-1). In addition, the sample volume requirement is merely 500 nL with a probing light power of about 150 nW, which is very promising for safe detection of single or a few molecules of biological specimens.
authors.affiliation: State Key Laboratory of Modern Optical Instrumentation, Department of Optical Engineering, Zhejiang University, Hangzhou, 310027, China. zhang_lei@zju.edu.cn
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Pan
authors.initials: P
authors.lastname: Wang
authors.forename: Yao
authors.initials: Y
authors.lastname: Xiao
authors.forename: Huakang
authors.initials: H
authors.lastname: Yu
authors.forename: Limin
authors.initials: L
authors.lastname: Tong