title: Minireview: the role of the vacuolar ATPase in nematodes.
abstract: The vacuolar ATPase enzyme complex (V-ATPase) pumps protons across membranes, energised by hydrolysis of ATP. It is involved in many physiological processes and has been implicated in many different diseases. While the broader functions of V-ATPases have been reviewed extensively, the role of this complex in nematodes specifically has not. Here, the essential role of the V-ATPase in nematode nutrition, osmoregulation, synthesis of the cuticle, neurobiology and reproduction is discussed. Based on the requirement of V-ATPase activity, or components of the V-ATPase, for these processes, the potential of the V-ATPase as a drug target for nematode parasites, which cause a significant burden to human health and agriculture, is also discussed. The V-ATPase has all the characteristics of a suitable drug target against nematodes, however the challenge will be to develop a high-throughput assay with which to test potential inhibitors.
authors.affiliation: Research School of Biology, College of Medicine, Biology and Environment, Australian National University, Canberra ACT 0200, Australia.
authors.forename: Alison J
authors.initials: AJ
authors.lastname: Knight
authors.forename: Carolyn A
authors.initials: CA
authors.lastname: Behm
mesh_terms: D000818:Animals; D006801:Humans; D009348:Nematoda / Q000187:drug effects / Q000201:enzymology* / Q000502:physiology; D018377:Neurotransmitter Agents / Q000378:metabolism; D012098:Reproduction; D025262:Vacuolar Proton-Translocating ATPases / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D014882:Water-Electrolyte Balance
chemical_list: D018377:Neurotransmitter Agents; D025262:Vacuolar Proton-Translocating ATPases