title: Resveratrol modulates murine collagen-induced arthritis by inhibiting Th17 and B-cell function.
abstract: BACKGROUND
  Alcohol intake is inversely related to rheumatoid arthritis (RA) disease incidence and severity. Resveratrol, a safe, well-described plant-derived compound, possesses anti-inflammation and immune-regulatory properties and is present in red wine. As such, it could mediate anti-inflammatory properties of the latter and offer novel therapeutic utility in is own right.
  
  
  OBJECTIVE
  To evaluate the therapeutic effect of resveratrol on collagen-induced arthritis (CIA) and its putative immune modulation in mice.
  
  
  METHODS
  CIA was induced in DBA1 mice by immunisation with collagen II. Different doses of resveratrol were administered before or after the development of CIA. The levels of antibody and cytokines in serum or in draining lymph node (DLN) lymphocyte culture supernatants were measured by ELISA and Th17 cell development in DLN was monitored by flow cytometry.
  
  
  RESULTS
  Either prophylactic or therapeutic administration of resveratrol attenuated clinical parameters and bone erosion in CIA mice. The arthritis-protective effects were associated with markedly reduced serum levels of pro-inflammatory cytokines and collagen-specific, but not total, IgG, and with reduced numbers of Th17 cells and the production of IL-17 in DLN.
  
  
  CONCLUSIONS
  Resveratrol modulates inflammatory arthritis in rodents by selectively suppressing key cellular and humoral responses necessary for disease development. This may partly explain the protective effects of red wine but importantly may offer a novel, effective and safe pathway whereby novel agents could be developed to treat RA.
authors.affiliation: Institute of Infection, Immunity and Infl ammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
authors.forename: Gao
authors.initials: G
authors.lastname: Xuzhu
authors.forename: Mousa
authors.initials: M
authors.lastname: Komai-Koma
authors.forename: Bernard P
authors.initials: BP
authors.lastname: Leung
authors.forename: Hwee Siew
authors.initials: HS
authors.lastname: Howe
authors.forename: Charles
authors.initials: C
authors.lastname: McSharry
authors.forename: Iain B
authors.initials: IB
authors.lastname: McInnes
authors.forename: Damo
authors.initials: D
authors.lastname: Xu
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000276:immunology / Q000517:prevention & control; D001323:Autoantibodies / Q000096:biosynthesis; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D002478:Cells, Cultured; D016207:Cytokines / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000379:methods; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D018836:Inflammation Mediators / Q000378:metabolism; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D058504:Th17 Cells / Q000187:drug effects* / Q000276:immunology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001323:Autoantibodies; D016207:Cytokines; D007166:Immunosuppressive Agents; D018836:Inflammation Mediators; D013267:Stilbenes; D000077185:Resveratrol