title: Two different dosing regimens of human recombinant erythropoietin beta during preoperative autologous blood donation in patients having hip arthroplasty.
abstract: OBJECTIVE
  Our aim was to evaluate the effectiveness of two different dosing regimens of human recombinant erythropoietin (rHu-EPO) for preoperative autologous blood collection in patients undergoing total hip arthroplasty (THA).
  
  
  METHODS
  Prospective randomised trials in which erythropoietin 15,000 IU was administered intravenously twice a week or 30,000 IU once a week (total 90,000 IU) combined with ferrous II sulphate (Ferro-Gradumet 2) orally and compared with Ferro-Gradumet 2 alone.
  
  
  RESULTS
  Although different dosing regimens of rHu-EPO administration during preoperative autologous blood donation have similar effects on the collection of two units of autologous blood, preoperative haemoglobin level and perioperative allogenic blood transfusion, a once weekly dose regimen of rHu-EPO was more convenient (although not statistically significantly) for patients.
  
  
  CONCLUSIONS
  We recommend the more practical and comfortable but yet highly effective therapeutic regimen with a single weekly intravenous administration of rHu-EPO for patients scheduled for THA.
authors.affiliation: Department of Orthopaedic Surgery, Clinical Hospital Centre Zagreb, School of Medicine, University of Zagreb, Zagreb, Croatia.
authors.forename: Melita
authors.initials: M
authors.lastname: Buljan
authors.forename: Damir
authors.initials: D
authors.lastname: Nemet
authors.forename: Branka
authors.initials: B
authors.lastname: Golubic-Cepulic
authors.forename: Goran
authors.initials: G
authors.lastname: Bicanic
authors.forename: Branko
authors.initials: B
authors.lastname: Tripkovic
authors.forename: Domagoj
authors.initials: D
authors.lastname: Delimar
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip / Q000379:methods*; D001804:Blood Transfusion, Autologous / Q000379:methods*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004921:Erythropoietin / Q000008:administration & dosage*; D005260:Female; D005296:Ferrous Compounds / Q000008:administration & dosage; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000378:metabolism / Q000601:surgery*; D011300:Preoperative Care; D011994:Recombinant Proteins
chemical_list: D005296:Ferrous Compounds; D006454:Hemoglobins; D011994:Recombinant Proteins; D004921:Erythropoietin; C020748:ferrous sulfate