title: Early-pregnancy changes in maternal lipid profile in women with recurrent preeclampsia and previously preeclamptic women with normal next pregnancy.
abstract: OBJECTIVE
  To evaluate early-pregnancy changes in lipid profile in recurrent preeclampsia.
  
  
  METHODS
  In this retrospective observational study, blood samples were obtained from 41 normotensive women with a history of early-onset preeclampsia preconceptionally and at 12 and 16 weeks in the next pregnancy. We assessed triglycerides (TGs), total cholesterol (TC), and high- and low-density lipoprotein cholesterol (HDL-C and LDL-C, respectively). We analyzed differences in longitudinal patterns between normal and recurrent preeclamptic next pregnancy using mixed-design repeated measurements analysis of covariance (ANCOVA).
  
  
  RESULTS
  Eleven (28%) women developed recurrent preeclampsia. Eighteen (45%) women had a normal pregnancy. In normal pregnancy, LDL-C declines transiently in the first trimester (P < .01). In women who develop recurrent preeclampsia later on this decline was absent. Moreover, from 12 weeks onward the elevating levels of HDL-C stagnates in women who subsequently develop recurrent preeclampsia (P = .02).
  
  
  CONCLUSIONS
  These observations point to an abnormal early adaptation of lipid metabolism to pregnancy preceding clinical manifestation of preeclampsia.
authors.affiliation: Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands. s.sep@mumc.nl
authors.forename: Simone
authors.initials: S
authors.lastname: Sep
authors.forename: Carmen
authors.initials: C
authors.lastname: Rijvers
authors.forename: Luc
authors.initials: L
authors.lastname: Smits
authors.forename: Marc
authors.initials: M
authors.lastname: van Bilsen
authors.forename: Otto
authors.initials: O
authors.lastname: Bekers
authors.forename: Louis
authors.initials: L
authors.lastname: Peeters
mesh_terms: D000328:Adult; D002784:Cholesterol / Q000097:blood; D015331:Cohort Studies; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008137:Longitudinal Studies; D011225:Pre-Eclampsia / Q000097:blood / Q000378:metabolism*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D012189:Retrospective Studies; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; D002784:Cholesterol