title: [Tissue and cell interactions in the oral mucosa after cytostatic drugs administration].
abstract: In the preceding work ("Morphology", 2011, issue 2), the regularities of oral mucosal (OM) epithelium injury after the cytostatic drug (CSD) treatment and its further regeneration, were reviewed. This paper presents the systematized summary of current literature data and the authors' own findings on the regularities of CSD effect on non-epithelial OM cell populations and their interactions with each other and the epithelium. The changes of intraepithelial tissue homeostasis, associated with CSD effect on intraepithelial lymphocytes, granulocytes, dendritic antigen presenting cells and melanocytes, interacting with epitheliocytes, are described. The data are presented, indicating that along with the epithelium, the cell populations of lamina propria and submucosal connective tissue, as well as the small blood vessels, are important targets of CSD in the OM tissues. The concept of a unifying model, describing tissue, cellular and molecular mechanisms of the oral mucositis development after CSD treatment, is reviewed.
authors.forename: V L
authors.initials: VL
authors.lastname: Bykov
authors.forename: I V
authors.initials: IV
authors.lastname: Leont'eva
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000187:drug effects*; D054697:Cytostatic Agents / Q000009:adverse effects*; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D009061:Mouth Mucosa / Q000098:blood supply / Q000166:cytology / Q000187:drug effects; D013280:Stomatitis / Q000139:chemically induced
chemical_list: D054697:Cytostatic Agents