title: Wnt signaling as a potential therapeutic target for frontotemporal dementia.
abstract: Progranulin mutations result in frontotemporal dementia, but the underlying pathophysiology has remained largely unexplained. New data by Geschwind and colleagues in this issue of Neuron uncovered that the Wnt/FZD2 signaling pathway is an early and critical contributor to disease pathology.
authors.affiliation: Department of Psychiatry and Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37232, USA. zeljka.korade@vanderbilt.edu
authors.forename: Zeljka
authors.initials: Z
authors.lastname: Korade
authors.forename: Károly
authors.initials: K
authors.lastname: Mirnics