title: [Raltegravir in a special case: patient with HIV and Burkitt's lymphoma].
abstract: METHODS
  A 38-year-old HIV positive man suffered from right upper abdominal pain and oesophageal reflux syndromes. He was in a good general state of health and nutrition with no concomitant symptoms.
  
  
  METHODS
  A small bowel tumor and slight soor esophagitis had been diagnosed by esophago-gastroduodenoscopy. The tumor was histologically classified as Burkitt?s lymphoma.
  
  
  RESULTS
  The patient received 6 cycles of chemotherapy according to the B-ALL protocol, and antiretroviral therapy with lamivudine (300 mg), abacavir (600 mg) und raltegravir (2 × 400 mg) was initiated immediately. After the first cycle of chemotherapy a complete remission of Burkitt?s lymphoma was achieved. Laboratory parameters recovered after completion of 6 cycles to a value of 400 CD4-positive lymphocytes/mm (3) with a viral load of HIV-1-RNA 20 - 300 copies/ml in plasma.
  
  
  CONCLUSIONS
  Immediate initiation of antiretroviral therapy is essential after the diagnosis of AIDS-defining symptoms. The choice of an appropriate treatment regimen is a critical factor in order to avoid toxic drug interactions and adverse events while maintaining a highly effective treatment.
authors.affiliation: Facharzt für Innere Medizin, Privatpraxis Berlin.
authors.forename: B
authors.initials: B
authors.lastname: Bieniek
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002051:Burkitt Lymphoma / Q000175:diagnosis / Q000188:drug therapy*; D018791:CD4 Lymphocyte Count; D015224:Dideoxynucleosides / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004379:Duodenal Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D006679:HIV Seropositivity / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007421:Intestine, Small; D019259:Lamivudine / Q000627:therapeutic use; D016483:Lymphoma, AIDS-Related / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D011760:Pyrrolidinones / Q000009:adverse effects / Q000627:therapeutic use*; D000068898:Raltegravir Potassium; D012074:Remission Induction; D019562:Viral Load; D000099227:Abacavir
chemical_list: D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; D019259:Lamivudine; D011760:Pyrrolidinones; D000068898:Raltegravir Potassium; D000099227:Abacavir