title: Biochemical markers analyzed using microdialysis and traumatic brain injury outcomes.
abstract: OBJECTIVE
  Traumatic brain injury is a leading cause of disability and mortality among young people. Multiparametric cerebral bedside monitoring is a safe and promising technique for preventing secondary brain damage. The objective of this study was to investigate the usefulness of cerebral microdialysis in predicting the outcomes of patients with traumatic brain injury.
  
  
  METHODS
  Thirty-eight patients (33 males) were included in the study. The GCS on admission was ≤8. The outcome was assessed using the GOS over six months of follow-up.
  
  
  RESULTS
  Among the patients included, 18 had a favorable outcome (GOS=4.5) and the remaining 20 had an unfavorable outcome. L/P ratio and glycerol concentration were statistically significantly higher in the patients with unfavorable prognosis.
  
  
  CONCLUSIONS
  Biochemical parameters analysed using microdialysis could serve as predictor indexes of clinical outcome several months after the injury.
authors.affiliation: Intensive Care Unit, Achillopoulio General Hospital, Volos, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Karathanou
authors.forename: K
authors.initials: K
authors.lastname: Paterakis
authors.forename: M
authors.initials: M
authors.lastname: Pakopoulou
authors.forename: A
authors.initials: A
authors.lastname: Tasiou
authors.forename: G
authors.initials: G
authors.lastname: Hadjigeorgiou
authors.forename: A
authors.initials: A
authors.lastname: Chovas
authors.forename: G
authors.initials: G
authors.lastname: Paraforos
authors.forename: K
authors.initials: K
authors.lastname: Fountas
authors.forename: A
authors.initials: A
authors.lastname: Komnos
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D001930:Brain Injuries / Q000175:diagnosis* / Q000378:metabolism* / Q000628:therapy; D003422:Critical Care / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism; D008297:Male; D017551:Microdialysis / Q000379:methods*; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods*; D011237:Predictive Value of Tests; D011379:Prognosis; D019289:Pyruvic Acid / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D019344:Lactic Acid; D019289:Pyruvic Acid