title: Bilateral thoracic sympathetic block for refractory polymorphic tachycardia.
abstract: BACKGROUND
  Extensive evidence has established a link between sympathetic nervous system hyperactivity, ventricular arrhythmias, and sudden cardiac death. For this reason, cardiac sympathectomy is often beneficial in the treatment of patients at high risk for ventricular ectopy, although it involves an invasive procedure associated with potential morbidity. We report a case in which we used guided lytic thoracic sympathetic block in a patient with underlying cardiomyopathy and refractory polymorphic ventricular tachycardia.
  
  
  METHODS
  A 74-yr-old African American male with ischemic cardiomyopathy presented with refractory episodes of ventricular tachycardia despite maximal medical therapy involving antiarrhythmic drugs and previous interventions, including endovascular epicardial ablation and open cryoablation via sternotomy. During his inpatient admission, the patient developed sustained ventricular tachycardia associated with cardiac depression requiring vasopressors. An open thoracoscopic sympathectomy was considered as a possible treatment, but in our view, the patient would not tolerate this procedure. As an alternative, the pain medicine team successfully performed a lytic thoracic sympathetic block. Subsequently, the patient demonstrated a period of clinical improvement with no apparent morbidity related to the procedure.
  
  
  CONCLUSIONS
  Lytic thoracic sympathetic blockade is a novel technique for the treatment of sympathetically mediated ventricular tachycardia, and it is less invasive than other types of cardiac sympathectomy. Additional studies are required to evaluate this treatment as a viable alternative in patients at high risk for ventricular ectopy. This report suggests the feasibility of this approach and the potential for minimal morbidity in cases of refractory ventricular arrhythmias.
authors.affiliation: Department of Anesthesiology and Critical Care, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA. fredallenmd@gmail.com
authors.forename: Frederick
authors.initials: F
authors.lastname: Allen
authors.forename: Brian
authors.initials: B
authors.lastname: Weaver
authors.forename: Adam
authors.initials: A
authors.lastname: Burkey
mesh_terms: D000368:Aged; D001340:Autonomic Nerve Block / Q000379:methods*; D009202:Cardiomyopathies / Q000503:physiopathology*; D005240:Feasibility Studies; D006801:Humans; D008297:Male; D017202:Myocardial Ischemia / Q000503:physiopathology; D017180:Tachycardia, Ventricular / Q000503:physiopathology / Q000628:therapy*; D013904:Thoracic Vertebrae; D016896:Treatment Outcome; D014662:Vasoconstrictor Agents / Q000627:therapeutic use
chemical_list: D014662:Vasoconstrictor Agents