title: Obstetric outcomes after treatment for cervical intraepithelial neoplasia: six years of experience.
abstract: OBJECTIVE
  : The purpose of this study was to assess the effect of cervical conization on subsequent pregnancy and delivery outcomes.
  
  
  METHODS
  : A retrospective case-control study was performed in patients who underwent conization from 2000 to 2005 and had a subsequent delivery. Two case controls were matched for each case studied. The obstetric outcomes of the 2 groups were compared. A subsequent analysis comparing the 2 excisional techniques used was performed.
  
  
  RESULTS
  : The study population group included 87 women (29 cases and 58 controls). Overall, the mean gestation age at delivery (38 vs 39 wk, p = .003), prevalence of preterm birth (20.7% vs 5.2%, p = .025), mean birth weight (3,035 vs 3279 g, p = .018), and low birth weight (20.7% vs 1.7%, p = .02) were statistically different among the cases and controls.In the study group (n = 29), large loop excision of the transformation zone was used in 62% (n = 18) and laser was used in 38% (n = 11) of the cases. There was no significant difference in the medium depth of the excised tissue, the prevalence of preterm birth, low birth weight, and the cesarean delivery rate between the 2 techniques.
  
  
  CONCLUSIONS
  : Despite the small number of cases, this study indicates that excision of the transformation zone is associated with an increased risk of overall preterm delivery and low-birth weight infants in subsequent pregnancies. No significant difference was found between the 2 cervical excision procedures.
authors.affiliation: Colposcopy Unit, Gynecology Department, Dr Alfredo da Costa Maternity, Lisbon, Portugal.
authors.forename: Ana Furtado
authors.initials: AF
authors.lastname: Lima
authors.forename: Carla
authors.initials: C
authors.lastname: Francisco
authors.forename: Catarina
authors.initials: C
authors.lastname: Júlio
authors.forename: Tereza
authors.initials: T
authors.lastname: Paula
authors.forename: Adelaide
authors.initials: A
authors.lastname: Vitorino
authors.forename: Jorge
authors.initials: J
authors.lastname: Borrego
mesh_terms: D016022:Case-Control Studies; D002584:Cervix Uteri / Q000601:surgery*; D019092:Conization / Q000379:methods*; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D011247:Pregnancy; D047928:Premature Birth / Q000453:epidemiology; D012189:Retrospective Studies; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000601:surgery*; D002578:Uterine Cervical Dysplasia / Q000601:surgery*