title: Synthesis and biological evaluation of novel (thio)urea derivatives as potential antitumor agents.
abstract: A series of novel (thio)ureas containing the pyrimidinyl group was designed and synthesized. Their in-vitro antitumor activity against different human tumor cells was examined. Some of the compounds showed potential antitumor activity, which provided some hints for further studies on structure modification.
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, P. R. China.
authors.forename: Chuanfei
authors.initials: C
authors.lastname: Jin
authors.forename: Yong-Ju
authors.initials: YJ
authors.lastname: Liang
authors.forename: Hongwu
authors.initials: H
authors.lastname: He
authors.forename: Liwu
authors.initials: L
authors.lastname: Fu
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D011743:Pyrimidines; D013890:Thiourea