title: [Vaccination and celiac disease: results of a retrospective study].
abstract: OBJECTIVE
  Human leucocyte antigen (HLA) system plays an essential role in the human immune system activity and the expression of some specific HLA antigens could modify the immune response to vaccinations. Celiac disease is included among the diseases associated to specific HLA profiles, principally characterized by the expression of the HLA DQ2 antigen.
  
  
  METHODS
  Our study was a retrospective study, leaded on a group of celiac children, with the object to evaluate their immunological response to both obligatory and recommended vaccinations in childhood. It was a retrospective study, including 66 patients affected by celiac disease, between 3 and 15 years of age, and a control group of 50 children of the same age. All patients performed both obligatory and recommended vaccinations as indicated in the Italian standard regimen for vaccinations. The immunologic response to each vaccine was analysed and compared in the two groups. Moreover, authors also studied the immunologic response to vaccines in celiac children comparing patients whose diagnosis was made before 18 months of age with those whose disease was diagnosed after 18 months of age.
  
  
  RESULTS
  Our results showed that in celiac patients the immunological response to vaccine is similar to that one found in general population, except for HBV vaccine.
  
  
  CONCLUSIONS
  The evaluation of immunological response to HBV vaccine should be regularly effectuated in celiac children and revaccination should be recommended.
authors.affiliation: Dipartimento di Pediatria, Università degli studi di Catania, Catania, Italia.
authors.forename: S
authors.initials: S
authors.lastname: Leonardi
authors.forename: R
authors.initials: R
authors.lastname: Longo
authors.forename: M
authors.initials: M
authors.lastname: Cotugno
authors.forename: L
authors.initials: L
authors.lastname: Tardino
authors.forename: M
authors.initials: M
authors.lastname: Spina
authors.forename: E
authors.initials: E
authors.lastname: Lionetti
authors.forename: M
authors.initials: M
authors.lastname: La Rosa
mesh_terms: D000293:Adolescent; D000906:Antibodies / Q000097:blood; D002446:Celiac Disease / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D014611:Vaccination; D014612:Vaccines / Q000276:immunology*
chemical_list: D000906:Antibodies; D014612:Vaccines