title: The improvement of hypoxia correlates with neuroanatomic and developmental outcomes: comparison of midterm outcomes in infants with transposition of the great arteries or single-ventricle physiology.
abstract: OBJECTIVE
  We performed a prospective longitudinal study of the neuroanatomic and developmental changes in infants with transposition of the great arteries (TGA) or single-ventricle (SV) physiology to identify variables in anatomic development of the brain associated with functional impairment.
  
  
  METHODS
  Thirty-three infants with congenital heart defects, 23 with SV and 10 with TGA, were studied at around 1 year old (time 1) and 3 years old (time 2) by magnetic resonance imaging of the brain. Neurodevelomental assessment was performed at the same time.
  
  
  RESULTS
  The whole and frontal lobe volumes were significantly reduced in both groups at time 1 compared with normal control subjects (P < .01). However, by time 2 whole and frontal brain volumes were normal in the TGA group but remained significantly smaller (P < .01) in the SV group. In agreement with these findings, the mental development index (MDI) was lower (P < .05) at time 1 in both groups but improved to normal levels at time 2 in the TGA group. In the SV group, both MDI and the psychomotor development index (PDI) were significantly decreased at both time 1 and time 2 (P < .01). These patients continued to experience hypoxia, and multivariate analysis revealed that functional oxygen saturation was significantly associated with PDI. Further, the PDI score correlated with whole and regional brain volumes (P < .05).
  
  
  CONCLUSIONS
  Neuroanatomic and developmental outcomes improve progressively in infants with TGA, unlike those with SV physiology. Impaired cerebral circulation and hypoxia may have significant effects on brain growth and development in infants with critical congenital heart disease.
authors.affiliation: Department of Pediatrics, University of Toyama, Toyama, Japan.
authors.forename: Keijiro
authors.initials: K
authors.lastname: Ibuki
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Watanabe
authors.forename: Naoki
authors.initials: N
authors.lastname: Yoshimura
authors.forename: Tachiyo
authors.initials: T
authors.lastname: Kakimoto
authors.forename: Mie
authors.initials: M
authors.lastname: Matsui
authors.forename: Taketoshi
authors.initials: T
authors.lastname: Yoshida
authors.forename: Hideki
authors.initials: H
authors.lastname: Origasa
authors.forename: Fukiko
authors.initials: F
authors.lastname: Ichida
mesh_terms: D000367:Age Factors; D001921:Brain / Q000254:growth & development* / Q000473:pathology / Q000503:physiopathology; D006348:Cardiac Surgical Procedures; D016022:Case-Control Studies; D002657:Child Development; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006352:Heart Ventricles / Q000002:abnormalities / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D000860:Hypoxia / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D021621:Imaging, Three-Dimensional; D007223:Infant; D007564:Japan; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D009929:Organ Size; D011446:Prospective Studies; D011597:Psychomotor Performance; D018570:Risk Assessment; D012307:Risk Factors; D014188:Transposition of Great Vessels / Q000150:complications / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D016896:Treatment Outcome