title: [Expression of cytoskeleton genes in culture of human mesenchymal stromal cells in different periods of simulating the effects of microgravity].
abstract: Simulation of microgravity for cultivated multipotent mesenchymal stromal cells (MSCs) from human marrow changes transiently expression of genes associated with actin cytoskeleton; the effect fades away partially in 120 hrs. following microgravity and completely after 24-hr cell readaptation to static conditions. These changes in expression of some cytoskeleton genes seem to predetermine their reaction to simulated microgravity, and therefore inhibition of MSCs differentiation potential.
authors.forename: P M
authors.initials: PM
authors.lastname: Gershkovich
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Gershkovich
authors.forename: L B
authors.initials: LB
authors.lastname: Buravkova
mesh_terms: D000222:Adaptation, Physiological; D001854:Bone Marrow Cells / Q000378:metabolism; D002478:Cells, Cultured; D003598:Cytoskeletal Proteins / Q000235:genetics*; D003599:Cytoskeleton / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000378:metabolism*; D017154:Stromal Cells / Q000378:metabolism; D018474:Weightlessness Simulation / Q000009:adverse effects*
chemical_list: D003598:Cytoskeletal Proteins