title: Correlation of new bone metabolic markers with conventional biomarkers in hemodialysis patients.
abstract: BACKGROUND
  New bone metabolic markers have become available clinically for evaluating chronic kidney disease mineral and bone disorders (CKD-MBD). The aim of this study was to correlate these new bone metabolic markers with conventional markers in regular hemodialysis (HD) patients.
  
  
  METHODS
  One hundred forty three HD patients underwent cross-sectional assessment. Two bone formation markers, bone-specific alkaline phosphatase (BAP) and osteocalcin (OC), and one bone resorption marker, amino-terminal telopeptides of type 1 collagen (NTx), were selected for study.
  
  
  RESULTS
  Both circulating OC and NTx levels showed positive correlations with serum intact parathyroid hormone (iPTH) levels. The levels of NTx and OC showed a strongly positive correlation, although they are known to be markers of different aspects of bone metabolism: bone formation and resorption. Patients with high iPTH (≥300pg/mL) had significantly higher levels of all the three bone markers compared with patients with low or normal iPTH .
  
  
  CONCLUSIONS
  Serum OC and NTx levels may be useful markers of serum iPTH levels for evaluating bone turnover in HD patients and may eventually prove useful in the management of patients with CKD-MBD.
authors.affiliation: Department of 4th Medicine, Tokyo Women’s Medical University, Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Takano
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Okano
authors.forename: Yuki
authors.initials: Y
authors.lastname: Tsuruta
authors.forename: Tetsuri
authors.initials: T
authors.lastname: Yamashita
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Echida
authors.forename: Naoko
authors.initials: N
authors.lastname: Miwa
authors.forename: Naoki
authors.initials: N
authors.lastname: Kimata
authors.forename: Takashi
authors.initials: T
authors.lastname: Akiba
authors.forename: Kosaku
authors.initials: K
authors.lastname: Nitta
mesh_terms: D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D001842:Bone and Bones / Q000378:metabolism*; D024042:Collagen Type I / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D010281:Parathyroid Hormone / Q000097:blood; D010455:Peptides / Q000097:blood; D006435:Renal Dialysis
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D010281:Parathyroid Hormone; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D000469:Alkaline Phosphatase