title: Giant cell tumor of the odontoid in an adolescent male: radiation, chemotherapy, and resection for recurrence with 10-year follow-up.
abstract: Giant cell tumors (GCTs) are rare lesions of the cervical spine, with only 14 previously reported pediatric cases in the literature, all occurring in females. The authors present the case of a 15-year-old boy with neck pain who was found to have a lytic GCT of the odontoid process. Following resection, recurrent disease was treated with radiotherapy and chemotherapy and then a final resection. He has remained tumor free for more than 10 years. The rarity of GCTs can make their diagnosis difficult in the cervical spine. Because of their aggressive behavior and relative resistance to adjuvant therapy, GCTs must be monitored diligently and treated aggressively.
authors.affiliation: Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, California 90048, USA. ali.shirzadi@cshs.org
authors.forename: Ali
authors.initials: A
authors.lastname: Shirzadi
authors.forename: Doniel
authors.initials: D
authors.lastname: Drazin
authors.forename: Serguei
authors.initials: S
authors.lastname: Bannykh
authors.forename: Moise
authors.initials: M
authors.lastname: Danielpour
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001265:Athletic Injuries / Q000150:complications*; D001859:Bone Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D002574:Cervical Vertebrae / Q000293:injuries / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D018212:Giant Cell Tumor of Bone / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D006801:Humans; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008297:Male; D019838:Neck Injuries / Q000150:complications* / Q000209:etiology; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D019635:Neurosurgical Procedures / Q000379:methods; D009809:Odontoid Process / Q000293:injuries / Q000473:pathology / Q000601:surgery; D018714:Radiotherapy, Adjuvant; D012086:Reoperation; D012509:Sarcoma / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D012916:Soccer; D016896:Treatment Outcome