title: Identification of novel plasmin inhibitors possessing nitrile moiety as warhead.
abstract: Lysine-nitrile derivatives having a trisubstituted benzene, which belongs to a new chemical class, were prepared and tested for inhibitory activities against plasmin and the highly homologous plasma kallikrein and urokinase. The use of the novel chemotype in the development of plasmin inhibitors has been demonstrated by derivatives of compound 9.
authors.affiliation: Hiroshima International University, Faculty of Pharmaceutical Science, 5-1-1, Hirokoshingai, Kure, Hiroshima 737-0112, Japan. n-teno@ps.hirokoku-u.ac.jp
authors.forename: Naoki
authors.initials: N
authors.lastname: Teno
authors.forename: Keigo
authors.initials: K
authors.lastname: Gohda
authors.forename: Keiko
authors.initials: K
authors.lastname: Wanaka
authors.forename: Takuya
authors.initials: T
authors.lastname: Sueda
authors.forename: Yuko
authors.initials: Y
authors.lastname: Tsuda
mesh_terms: D005341:Fibrinolysin / Q000037:antagonists & inhibitors*; D008958:Models, Molecular; D009570:Nitriles / Q000737:chemistry*
chemical_list: D009570:Nitriles; D005341:Fibrinolysin