title: Preparation of cross-linked carboxymethyl jackfruit starch and evaluation as a tablet disintegrant.
abstract: The main purposes of this study are to prepare cross-linked carboxymethyl jackfruit starch (CL-CMJF) and to evaluate its pharmaceutical property as a tablet disintegrant. CL-CMJF was prepared by a dual carboxymethyl-crosslinking reaction in a flask containing jackfruit seed starch (JFS), chloroacetic acid (CAA), sodium hydroxide (NaOH) and sodium trimetaphosphate (STMP). The reaction was carried out using methanol as a solvent for 60 min at 70°C and at JFS:CAA:NaOH:STMP ratio of 1.0:0.29:0.28:0.07. The obtained CL-CMJF, with degree of substitution and degree of crosslinking calculated to be 0.34 and 0.06, respectively, was insoluble but swellable in water. Rheological study revealed a decreased in solution viscosity compared to the non-crosslinked CMJF. The water uptake of CL-CMJF was 23 times higher than that of native starch and was comparable to that of a commercial superdisintegrant, sodium starch glycolate (SSG). The swelling ability of CL-CMRS was similar to that of crosscarmellose sodium (CCS), another commercial superdisintegrant. Disintegration test of aspirin tablets containing 2%w/w of JFS, CL-CMJF, SSG and CCS showed disintegration times in the order of SSG < CCS ~ CL-CMJF <<< JFS. The results suggested that CL-CMJF could be developed as a tablet disintegrant.
authors.affiliation: Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Nisit
authors.initials: N
authors.lastname: Kittipongpatana
authors.forename: Janta
authors.initials: J
authors.lastname: Suwakon
authors.forename: Ornanong
authors.initials: O
authors.lastname: Kittipongpatana
mesh_terms: D000085:Acetates / Q000737:chemistry; D031622:Artocarpus / Q000737:chemistry*; D001241:Aspirin / Q000008:administration & dosage; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry; D005079:Excipients / Q000138:chemical synthesis / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D011122:Polyphosphates / Q000737:chemistry; D012639:Seeds / Q000737:chemistry; D012995:Solubility; D013213:Starch / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification; D013607:Tablets / Q000737:chemistry*; D014783:Viscosity; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D000085:Acetates; D003432:Cross-Linking Reagents; D005079:Excipients; D011122:Polyphosphates; D013607:Tablets; D014867:Water; C006972:chloroacetic acid; D013213:Starch; C034848:carboxymethyl starch; C048390:sodium starch glycolate; C009293:trimetaphosphoric acid; D002266:Carboxymethylcellulose Sodium; D001241:Aspirin