title: Revisiting the Role of Acetylcholinesterase in Alzheimer's Disease: Cross-Talk with P-tau and β-Amyloid.
abstract: A common feature in the Alzheimer's disease (AD) brain is the presence of acetylcholinesterase (AChE) which is commonly associated with β-amyloid plaques and neurofibrillary tangles (NFT). Although our understanding of the relationship between AChE and the pathological features of AD is incomplete, increasing evidence suggests that both β-amyloid protein (Aβ) and abnormally hyperphosphorylated tau (P-tau) can influence AChE expression. We also review recent findings which suggest the possible role of AChE in the development of a vicious cycle of Aβ and P-tau dysregulation and discuss the limited and temporary effect of therapeutic intervention with AChE inhibitors.
authors.affiliation: Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-CSIC Alacant, Spain.
authors.forename: María-Salud
authors.initials: MS
authors.lastname: García-Ayllón
authors.forename: David H
authors.initials: DH
authors.lastname: Small
authors.forename: Jesús
authors.initials: J
authors.lastname: Avila
authors.forename: Javier
authors.initials: J
authors.lastname: Sáez-Valero