title: HASTE diffusion-weighted MRI for the reliable detection of cholesteatoma.
abstract: OBJECTIVE
  To assess the detection efficiency of Half-Fourier acquisition single-shot turbo spin-echo (HASTE) diffusion-weighted magnetic resonance imaging (MRI) for cholesteatoma.
  
  
  METHODS
  A total of 21 patients with suspected primary (n=16) or recurrent cholesteatoma (n=5) underwent MRI in a 1.5 Tesla scanner using an adapted protocol for cholesteatoma detection that included a coronal HASTE diffusion-weighted MRI sequence. The cholesteatoma diagnosis was based on evidence of a hyperintense lesion at b-1000 on diffusion-weighted images. The imaging findings were correlated with findings from surgery or clinical evaluations in all patients.
  
  
  RESULTS
  HASTE diffusion-weighted MRI successfully detected 11 primary and 5 recurrent lesions out of 17 cholesteatomas (sensitivity, 94.1%). One primary cholesteatoma with a diameter of 4-5 mm was missed. MRI of patients without cholesteatoma were correctly interpreted as negative for cholesteatoma (specificity, 100%). The positive and negative predictive values for the HASTE diffusion-weighted MRI in detecting cholesteatoma were 100% and 80%, respectively.
  
  
  CONCLUSIONS
  HASTE diffusion-weighted MRI offers great promise for cholesteatoma screening. The addition of this sequence to the posterior fossa MRI protocol may preclude unnecessary cholesteatoma surgery.
authors.affiliation: Department of Radiology, Gülhane Military Medical School, Ankara, Turkey. aturca2002@yahoo.com
authors.forename: A Turan
authors.initials: AT
authors.lastname: Ilıca
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Hıdır
authors.forename: Nail
authors.initials: N
authors.lastname: Bulakbaşı
authors.forename: Bülent
authors.initials: B
authors.lastname: Satar
authors.forename: Inanç
authors.initials: I
authors.lastname: Güvenç
authors.forename: Hasan Hüseyin
authors.initials: HH
authors.lastname: Arslan
authors.forename: Nurcan
authors.initials: N
authors.lastname: Imre
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018424:Cholesteatoma, Middle Ear / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D015331:Cohort Studies; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D013506:Otologic Surgical Procedures / Q000379:methods; D011446:Prospective Studies; D012008:Recurrence; D012016:Reference Values; D012086:Reoperation / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D055815:Young Adult