title: [Establishment and evaluation of a modified plasma protamine paracoagulation test].
abstract: OBJECTIVE
  To establish a modified plasma protamine paracoagulation test.
  
  
  METHODS
  Plasma protamine paracoagulation, modified plasma protamine paracoagulation and D-dimer (D-D) tests were performed for the plasma samples collected from 98 cases of disseminated intravascular coagulation (DIC) and 156 normal subjects. The sensitivity and specificity of the 3 tests were analyzed. The plasma samples from 8 cases of suspected myocardial infarction were detected using modified plasma protamine paracoagulation for diagnostic purpose.
  
  
  RESULTS
  The sensitivity of plasma protamine paracoagulation, modified plasma protamine paracoagulation and D-D tests was 16.33%, 88.76% and 77.56%, and the specificity was 100%, 88.46% and 97.44%, respectively. Positive results occurred earlier in modified plasma protamine paracoagulation test than in plasma protamine paracoagulation and D-D tests in 5 cases of myocardial infarction.
  
  
  CONCLUSIONS
  The modified plasma protamine paracoagulation test has a higher sensitivity than plasma protamine paracoagulation test and a higher specificity than D-D test, and can be helpful in early diagnosis of thrombosis and fibrinolysis.
authors.affiliation: 173 Clinic, 421 Hospital of PLA, Huizhou 516008, China. 380103228@qq.com
authors.forename: Xu-hua
authors.initials: XH
authors.lastname: Tang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.forename: Wen-hao
authors.initials: WH
authors.lastname: Lin
authors.forename: Lin
authors.initials: L
authors.lastname: Fu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Xie
authors.forename: Yu-ming
authors.initials: YM
authors.lastname: Zhang
mesh_terms: D000328:Adult; D001780:Blood Coagulation Tests / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011479:Protamines / Q000097:blood*; D012680:Sensitivity and Specificity; D013927:Thrombosis / Q000097:blood / Q000175:diagnosis*
chemical_list: D011479:Protamines