title: [Expression of cell adhesion molecules in the maternal fetal period of human gestation].
abstract: BACKGROUND
  The human labor is an inflammatory process invading leukocytes modulated by gestational tissues. The local increase of cell adhesion molecules (CAMs) promotes the permanence of these leukocytes in the coriodecidua. Gestational tissues express ICAM-1, while circulating leukocytes expressing its ligand Mac-1.
  
  
  OBJECTIVE
  To analyze, first, if the expression of CAMs in the fetal membranes is associated with progress of gestational age, and second, the expression of CAMs on circulating leukocytes in the uterus (placenta).
  
  
  METHODS
  original and closed study conducted at the Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes (Mexico City). We included samples from healthy women between 15 and 44 years of age with term pregnancies (> or =37 weeks gestation).
  
  
  RESULTS
  Real time PCR analysis showed that the expression of CAMs in the fetal membranes remained constant before labor. ICAM3 and ICAM1 tended to increase during labor, while ICAM2, VCAM1, SELE and SELP decrease with advancing gestational age. Placental leukocytes showed a clear increase in the expression of ITGAM (Mac-1) during labor.
  
  
  CONCLUSIONS
  These results show that the maternal-fetal interface expresses a specific combination of CAMs during labor, including ICAM1, ICAM-3 and Mac-1. The expression of these molecules could promote the retention of leukocytes in the local tissues to modulate the local inflammatory microenvironment during human labor.
authors.affiliation: Departamento de Investigación en Nutrición, Instituto Nacional de Parinatología Isidro Espinosa de los Reyes, México, DF. r.vega@servidor.inper.edu.mx
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Vega-Sánchez
authors.forename: Elizabeth
authors.initials: E
authors.lastname: de Jesús-Torres
authors.forename: Marcia
authors.initials: M
authors.lastname: Arenas-Hernández
authors.forename: Jorge
authors.initials: J
authors.lastname: Beltrán-Montoya
authors.forename: Rolando
authors.initials: R
authors.lastname: Maida-Claros
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Estrada-Gutiérrez
authors.forename: Felipe
authors.initials: F
authors.lastname: Vadillo-Ortega
mesh_terms: D000293:Adolescent; D000328:Adult; D001363:Awards and Prizes; D001773:Blood Cells / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002634:Chemotaxis, Leukocyte; D003199:Computer Systems; D005321:Extraembryonic Membranes / Q000378:metabolism*; D005260:Female; D005865:Gestational Age; D006176:Gynecology; D006801:Humans; D007249:Inflammation; D007743:Labor, Obstetric / Q000378:metabolism*; D007962:Leukocytes / Q000378:metabolism*; D008800:Mexico; D009774:Obstetrics; D010920:Placenta / Q000166:cytology / Q000378:metabolism; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011263:Pregnancy Trimester, Third / Q000378:metabolism*; D055815:Young Adult
chemical_list: D015815:Cell Adhesion Molecules