title: Facile synthesis and altered ionization efficiency of diverse Nε-alkyllysine-containing peptides.
abstract: Protein lysine methylation is a biologically-important posttranslational modification. Given the increased use of alkyllysine-containing peptides to study protein methylation, we describe an efficient solid-phase synthesis to access various alkyllysine-containing peptides. As an exemplary application, we evaluated how ionization efficiency of the alkyllysine peptides affects mass spectrometric analysis.
authors.affiliation: Tri-Institutional Training Program in Chemical Biology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
authors.forename: Debjani
authors.initials: D
authors.lastname: Chakraborty
authors.forename: Kabirul
authors.initials: K
authors.lastname: Islam
authors.forename: Minkui
authors.initials: M
authors.lastname: Luo
mesh_terms: D008239:Lysine / Q000031:analogs & derivatives / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D010455:Peptides; D008239:Lysine