title: [Current methods of systemic amyloidosis diagnosis and monitoring of its course].
abstract: OBJECTIVE
  To determine clinical significance of measuring blood levels of protein precursors of AA- and AL-amyloidosis - SAA and immunoglobulin free light chains (ILC), respectively.
  
  
  METHODS
  SAA concentrations were studied with ELISA in 43 rheumatoid arthritis (RA) patients including complicated with reactive AA-amyloidosis (n = 31). Inflammation activity and its severity were studied (indices Li, richi, HAQ, DAS4). A modern quantitative nephelometric method Freelite estimated ILC levels in 31 patients with AL-amyloidosis.
  
  
  RESULTS
  Patients with RA complicated with AA-amyloidosis and free of it had a strong correlation between blood serum SAA concentration and activity of joint disease. Elevated SAA concentrations to 160 mg/l (normal 10 mg/l) were detected in many patients with clinical remission of the joint syndrome. Significal inhibition of AA-amyloidosis progression was seen only in SAA concentration drop under 60 mg/l. For AL-amyloidosis patients ILC fall by less than 3 normal value means a 6-time increase in chances of a favourable outcome.
  
  
  CONCLUSIONS
  Monitoring of blood levels of proteins precursors of AA- and AL-amyloidosis is a key factor in prognosis of the disease and treatment efficacy.
authors.forename: V V
authors.initials: VV
authors.lastname: Rameev
authors.forename: L V
authors.initials: LV
authors.lastname: Kozlovskaia
authors.forename: E A
authors.initials: EA
authors.lastname: Malinina
authors.forename: A G
authors.initials: AG
authors.lastname: Serova
authors.forename: I N
authors.initials: IN
authors.lastname: Kogarko
authors.forename: B S
authors.initials: BS
authors.lastname: Kogarko
authors.forename: N V
authors.initials: NV
authors.lastname: Liubimova
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000686:Amyloidosis / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D000685:Serum Amyloid A Protein / Q000032:analysis*; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D007147:Immunoglobulin Light Chains; D000685:Serum Amyloid A Protein