title: Hyperammonemic coma in an ornithine transcarbamylase mutation carrier following antepartum corticosteroids.
abstract: Women who are carriers of the ornithine transcarbamylase (OTC) mutation are at risk for developing hyperammonemia during the postpartum period and at times of metabolic stress. We present a unique case of hyperammonemic coma occurring in an OTC mutation carrier during the antepartum period. Multiple factors, including the administration of antenatal corticosteroids, likely precipitated this critical condition. Clinicians should be aware of this life-threatening clinical presentation and be prepared to identify, treat, and prevent hyperammonemia in affected individuals.
authors.affiliation: Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Evanston, IL, USA.
authors.forename: S
authors.initials: S
authors.lastname: Lipskind
authors.forename: S
authors.initials: S
authors.lastname: Loanzon
authors.forename: E
authors.initials: E
authors.lastname: Simi
authors.forename: D W
authors.initials: DW
authors.lastname: Ouyang
mesh_terms: D000328:Adult; D003128:Coma / Q000209:etiology*; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects / Q000627:therapeutic use; D006579:Heterozygote; D006801:Humans; D022124:Hyperammonemia / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D009154:Mutation; D007752:Obstetric Labor, Premature / Q000188:drug therapy; D009954:Ornithine Carbamoyltransferase / Q000235:genetics; D020163:Ornithine Carbamoyltransferase Deficiency Disease / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000235:genetics*
chemical_list: D005938:Glucocorticoids; D009954:Ornithine Carbamoyltransferase