title: Pharmacokinetics of Cyclosporine A in Chinese heart transplant recipients.
abstract: OBJECTIVE
  To determine the steady state concentration and the pharmacokinetics of Cyclosporine A (CsA) in heart transplant recipients.
  
  
  METHODS
  A single dose of 100 mg CsA capsules twice daily was given to five heart transplant recipients of steady state. The concentrations of CsA in plasma were determined by streptavidin peroxidase fluorescent polarization immunoassay.
  
  
  RESULTS
  The main pharmacokinetic parameters of CsA were as follows: t(max) (1.60 ± 0.55) h, ρmax(951.60 ± 229.20) μg.L-1, t1/2(6.53 ± 2.40) h, and AUC0 -t(5162.10 ± 1355.01) μg.h.L-1.
  
  
  CONCLUSIONS
  The study obtained the steady state pharmacokinetic parameters of CsA in Chinese heart transplant recipients.
authors.affiliation: Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Jin
authors.forename: Hongzhang
authors.initials: H
authors.lastname: Duan
authors.forename: Can
authors.initials: C
authors.lastname: Zhao
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.forename: Fujun
authors.initials: F
authors.lastname: Qu
mesh_terms: D000328:Adult; D044466:Asian People; D002681:China; D016572:Cyclosporine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D016027:Heart Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine