title: Tuberculosis of the central nervous system in immunocompromised patients: HIV infection and solid organ transplant recipients.
abstract: Central nervous system (CNS) tuberculosis (TB) is a devastating infection with high rates of morbidity and mortality worldwide and may manifest as meningitis, tuberculoma, abscess, or other forms of disease. Immunosuppression, due to either human immunodeficiency virus infection or solid organ transplantation, increases susceptibility for acquiring or reactivating TB and complicates the management of underlying immunosuppression and CNS TB infection. This article reviews how immunosuppression alters the clinical presentation, diagnosis, treatment, and outcome of TB infections of the CNS.
authors.affiliation: Department of Neurology, Global Health, Medicine, and Epidemiology, University of Washington School of Medicine, Seattle, Washington, USA.
authors.forename: Christina A
authors.initials: CA
authors.lastname: Nelson
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Zunt
mesh_terms: D002493:Central Nervous System Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology*; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D016867:Immunocompromised Host; D016377:Organ Transplantation / Q000009:adverse effects*; D016896:Treatment Outcome; D014376:Tuberculosis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology*