title: Identification of mutaprodenafil in a dietary supplement and its subsequent synthesis.
abstract: We isolated a new illegal sildenafil analogue named mutaprodenafil from a dietary supplement for erectile dysfunction (ED) and proposed that it is an aildenafil derivative containing an imidazole moiety. We subsequently synthesized mutaprodenafil from a thioaildenafil and authenticated its structure.
authors.affiliation: National Institute of Health Sciences, Tokyo, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Demizu
authors.forename: Daigo
authors.initials: D
authors.lastname: Wakana
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kamakura
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kurihara
authors.forename: Haruhiro
authors.initials: H
authors.lastname: Okuda
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Goda
mesh_terms: D019587:Dietary Supplements / Q000032:analysis; D004340:Drug Contamination; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D007093:Imidazoles / Q000032:analysis* / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008297:Male; D015394:Molecular Structure; D058986:Phosphodiesterase 5 Inhibitors / Q000032:analysis* / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D010879:Piperazines / Q000737:chemistry; D011687:Purines / Q000737:chemistry; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000737:chemistry
chemical_list: D007093:Imidazoles; D058986:Phosphodiesterase 5 Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; C573109:mutaprodenafil; C520604:aildenafil; D000068677:Sildenafil Citrate