title: Synthesis of α,α-disubstituted aryl amines by rhodium-catalyzed amination of tertiary allylic trichloroacetimidates.
abstract: The rhodium-catalyzed regioselective amination of tertiary allylic trichloroacetimidates with unactivated aromatic amines is a direct and efficient approach to the preparation of α,α-disubstituted allylic aryl amines in good yield and with excellent regioselectivity. This method is applicable to a variety of unactivated primary and secondary amines and allows for the preparation of reverse prenylated indoles in two steps.
authors.affiliation: Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Arnold
authors.forename: Gregory T
authors.initials: GT
authors.lastname: Cizio
authors.forename: Hien M
authors.initials: HM
authors.lastname: Nguyen
mesh_terms: D000081:Acetamides; D000586:Amination; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D062845:Chloroacetates; D020650:Combinatorial Chemistry Techniques; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism; D014238:Trichloroacetic Acid / Q000737:chemistry
chemical_list: D000081:Acetamides; D000588:Amines; D062845:Chloroacetates; D007211:Indoles; D014238:Trichloroacetic Acid; D012238:Rhodium; C009528:trichloroacetamide