title: Amygdala lesions selectively impair familiarity in recognition memory.
abstract: A major controversy in the study of memory concerns whether there are distinct medial temporal lobe (MTL) substrates of recollection and familiarity. Studies using receiver operating characteristics analyses of recognition memory indicate that the hippocampus is essential for recollection, but not for familiarity. We found the converse pattern in the amygdala, wherein damage impaired familiarity while sparing recollection. Combined with previous findings, these results dissociate recollection and familiarity by selective MTL damage.
authors.affiliation: Center for Memory and Brain, Boston University, Boston, Massachusetts, USA.
authors.forename: Anja
authors.initials: A
authors.lastname: Farovik
authors.forename: Ryan James
authors.initials: RJ
authors.lastname: Place
authors.forename: Danielle Renée
authors.initials: DR
authors.lastname: Miller
authors.forename: Howard
authors.initials: H
authors.lastname: Eichenbaum
mesh_terms: D000679:Amygdala / Q000293:injuries* / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal; D003216:Conditioning, Operant / Q000502:physiology; D008297:Male; D008569:Memory Disorders / Q000503:physiopathology*; D011939:Mental Recall / Q000502:physiology; D012372:ROC Curve; D051381:Rats; D020318:Rats, Long-Evans; D021641:Recognition, Psychology / Q000502:physiology*