title: [Sodium thiosulfate--new hope for the treatment of calciphylaxis].
abstract: Calciphylaxis is a rare disease primarily affecting patients dependent on dialysis. It is characterised by small vessel media calcification leading to cutaneous ischemia and necrosis. The mortality rate is high with infection and sepsis being the most common causes of death. Calcium salts, vitamin D and high levels of serum calcium and phosphorus increase the risk of calciphylaxis. Current therapies including restoration of mineral homeostasis, wound care and pain control, are not entirely effective. Sodium thiosulfate, by dissolving calcium deposits, is a novel therapeutic choice for calciphylaxis. It has proved successful also in cases refractory to conventional treatment.
authors.affiliation: TYKS:n Sisätautien Klinikka, Turku.
authors.forename: Maija
authors.initials: M
authors.lastname: Heiro
authors.forename: Leeni
authors.initials: L
authors.lastname: Mäkelä
authors.forename: Niina
authors.initials: N
authors.lastname: Koivuviita
authors.forename: Ilkka
authors.initials: I
authors.lastname: Manner
authors.forename: Risto
authors.initials: R
authors.lastname: Tertti
authors.forename: Ulla
authors.initials: U
authors.lastname: Hohenthal
authors.forename: Kaj
authors.initials: K
authors.lastname: Metsärinne
mesh_terms: D002115:Calciphylaxis / Q000188:drug therapy* / Q000209:etiology* / Q000401:mortality; D002614:Chelating Agents / Q000627:therapeutic use*; D006801:Humans; D006435:Renal Dialysis / Q000009:adverse effects*; D013885:Thiosulfates / Q000627:therapeutic use*
chemical_list: D002614:Chelating Agents; D013885:Thiosulfates; C017717:sodium thiosulfate