title: Review of the series "Disease of the year 2011: toxoplasmosis" pathophysiology of toxoplasmosis.
abstract: Toxoplasma gondii is a major cause of chronic parasitic infection in the world. This protozoan can cause retino-choroiditis in newborns and in adults, both immunocompetent and immunodeficient. This disease tends to be recurrent and can lead to severe visual impairment. The authors review current knowledge on the role of parasite genetics in influencing susceptibility to ocular toxoplasmosis and on the immuno-pathogenesis of this disease.
authors.affiliation: Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA. css34@case.edu
authors.forename: Carlos S
authors.initials: CS
authors.lastname: Subauste
authors.forename: Daniel
authors.initials: D
authors.lastname: Ajzenberg
authors.forename: Aize
authors.initials: A
authors.lastname: Kijlstra
mesh_terms: D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000150:complications / Q000276:immunology; D006801:Humans; D051379:Mice; D014122:Toxoplasma / Q000235:genetics* / Q000276:immunology; D014123:Toxoplasmosis / Q000235:genetics / Q000276:immunology* / Q000469:parasitology*
chemical_list: D000953:Antigens, Protozoan