title: The European Medicines Agency review of Tegafur/Gimeracil/Oteracil (Teysuno™) for the treatment of advanced gastric cancer when given in combination with cisplatin: summary of the Scientific Assessment of the Committee for medicinal products for human use (CHMP).
abstract: The product Teysuno™ (S-1) contains tegafur, a prodrug of 5-fluorouracil (5-FU), and two modulators of 5-FU metabolism, gimeracil and oteracil. The main clinical study in this application was a randomized controlled study comparing S-1 plus cisplatin with 5-FU plus cisplatin. In this study, median overall survival times of 8.6 months and 7.9 months for S-1 plus cisplatin and 5-FU plus cisplatin, respectively, were observed (hazard ratio, 0.92; 95% confidence interval, 0.80-1.05). The Committee for Medicinal Products for Human Use of the European Medicines Agency concluded that S-1 in combination with cisplatin (75 mg/m²) was noninferior to 5-FU plus cisplatin (100 mg/m²) in patients with advanced gastric cancer and adopted a positive opinion recommending the marketing authorization for this product for the treatment of advanced gastric cancer when given in combination with cisplatin. The recommended dose of S-1 is 25 mg/m² (expressed as tegafur content) twice a day, for 21 consecutive days followed by 7 days rest (one treatment cycle), in combination with 75 mg/m² cisplatin i.v. administered on day 1. This treatment cycle is repeated every 4 weeks. The most common side effects reported in the pivotal study were anemia, neutropenia, vomiting, diarrhea, abdominal pain, weight decrease, anorexia, and fatigue. The objective of this paper is to summarize the scientific review of the application leading to approval in the EU. The full scientific assessment report and the summary of product characteristics are available on the European Medicines Agency website (http://www.ema.europa.eu).
authors.affiliation: European Medicines Agency, London, UK. Petra.Matt@ema.europa.eu
authors.forename: Petra
authors.initials: P
authors.lastname: Matt
authors.forename: Barbara
authors.initials: B
authors.lastname: van Zwieten-Boot
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Calvo Rojas
authors.forename: Hadewych
authors.initials: H
authors.lastname: Ter Hofstede
authors.forename: Rocio
authors.initials: R
authors.lastname: Garcia-Carbonero
authors.forename: Jorge
authors.initials: J
authors.lastname: Camarero
authors.forename: Eric
authors.initials: E
authors.lastname: Abadie
authors.forename: Francesco
authors.initials: F
authors.lastname: Pignatti
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D004334:Drug Administration Schedule; D017277:Drug Approval; D005062:European Union; D006801:Humans; D010094:Oxonic Acid / Q000008:administration & dosage / Q000009:adverse effects; D017410:Practice Guidelines as Topic; D011725:Pyridines / Q000008:administration & dosage / Q000009:adverse effects; D016032:Randomized Controlled Trials as Topic; D013274:Stomach Neoplasms / Q000188:drug therapy*; D005641:Tegafur / Q000008:administration & dosage / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D011725:Pyridines; D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin; C104201:gimeracil