title: Association of genetic variations in mTOR with risk of childhood acute lymphoblastic leukemia in a Chinese population.
abstract: The mammalian target of rapamycin (mTOR) is an important protein kinase regulating cell survival and apoptosis. To determine whether genetic variations in mTOR are associated with risk of acute lymphoblastic leukemia (ALL) in Chinese children, we genotyped two tag single nucleotide poymorphisms (SNPs) in mTOR (rs2536 and rs2295080) in a case-control study. We observed that the variant genotype TC of mTOR rs2536 was associated with a significantly decreased risk of childhood ALL (adjusted odds ratio [OR] = 0.67, 95% confidence interval [CI] = 0.46-0.96), and the association was more pronounced in high-risk ALL and T-phenotype ALL groups. Additionally, we found that the combined genotypes TC/CC decreased the risk of ALL only in the high-risk ALL group (adjusted OR = 0.54, 95% CI = 0.32-0.91) and T-phenotype ALL group (adjusted OR = 0.29, 95% CI = 0.10-0.84). These results suggest that the mTOR rs2536 polymorphism is involved in the susceptibility to childhood ALL in a Chinese population.
authors.affiliation: Department of Hematology and Oncology, Nanjing Medical University, Nanjing, China.
authors.forename: Lizhen
authors.initials: L
authors.lastname: Huang
authors.forename: Jie
authors.initials: J
authors.lastname: Huang
authors.forename: Peng
authors.initials: P
authors.lastname: Wu
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.forename: Liucheng
authors.initials: L
authors.lastname: Rong
authors.forename: Yao
authors.initials: Y
authors.lastname: Xue
authors.forename: Qin
authors.initials: Q
authors.lastname: Lu
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.forename: Na
authors.initials: N
authors.lastname: Tong
authors.forename: Meilin
authors.initials: M
authors.lastname: Wang
authors.forename: Zhengdong
authors.initials: Z
authors.lastname: Zhang
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Fang
mesh_terms: D000293:Adolescent; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007223:Infant; D020641:Polymorphism, Single Nucleotide; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology / Q000235:genetics*; D012306:Risk; D058570:TOR Serine-Threonine Kinases / Q000235:genetics*
chemical_list: C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases