title: The tolerogenic interplay(s) among HLA-G, myeloid APCs, and regulatory cells.
abstract: Myeloid antigen-presenting cells (APCs), regulatory cells, and the HLA-G molecule are involved in modulating immune responses and promoting tolerance. APCs are known to induce regulatory cells and to express HLA-G as well as 2 of its receptors; regulatory T cells can express and act through HLA-G; and HLA-G has been directly involved in the generation of regulatory cells. Thus, interplay(s) among HLA-G, APCs, and regulatory cells can be easily envisaged. However, despite a large body of evidence on the tolerogenic properties of HLA-G, APCs, and regulatory cells, little is known on how these tolerogenic players cooperate. In this review, we first focus on key aspects of the individual relationships between HLA-G, myeloid APCs, and regulatory cells. In its second part, we highlight recent work that gathers individual effects and demonstrates how intertwined the HLA-G/myeloid APCs/regulatory cell relationship is.
authors.affiliation: Commissariat a l'Energie Atomique et aux Energies Alternatives-Institute d'Imagerie Biomedicale, Service de Recherches en Hemato-Immunologie, Hopital Saint Louis, 1 Avenue Claude Vellejause, Paris Cedex, France. edgardo.carosella@cea.fr
authors.forename: Edgardo D
authors.initials: ED
authors.lastname: Carosella
authors.forename: Silvia
authors.initials: S
authors.lastname: Gregori
authors.forename: Joel
authors.initials: J
authors.lastname: LeMaoult
mesh_terms: D000938:Antigen-Presenting Cells / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology; D059951:HLA-G Antigens / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D018448:Models, Immunological; D022423:Myeloid Cells / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D059951:HLA-G Antigens