title: Class II alleles HLA-DQB1* 0301 among a seven-membered Egyptian family of a child with oral pemphigoid.
abstract: OBJECTIVE
  The presence of HLA-DBQ1* 0301 allele in an Egyptian patient with oral pemphigoid and six of his family members was investigated.
  
  
  BACKGROUND
  Oral pemphigoid is a variant of vesiculobullous mucous membrane pemphigoid with an immunogenetic predisposition related to defects in major histocompatibility complex (OMIM 604305), HLA-DQB 1 alleles.
  
  
  METHODS
  High resolution typing of HLA-DQB 1*0301 allele was carried out for the seven members of an Egyptian family including the child affected with oral pemphigoid.
  
  
  RESULTS
  Both parents and three children including the proband were found to be carriers for the studied allele, while the other two children were not.
  
  
  CONCLUSIONS
  Participation of HLA-DBQ1*0301 allele was not informative for both susceptibility and/or phenotypic expression of the disease within the studied family (Fig. 2, Ref. 31).
authors.affiliation: Oro-dental Genetics Department, Division of Oral and Dental Medicine research National Research Centre, Cairo, Egypt. mostafanrc@yahoo.com
authors.forename: M I
authors.initials: MI
authors.lastname: Mostafa
authors.forename: W A
authors.initials: WA
authors.lastname: Zarouk
authors.forename: G Y
authors.initials: GY
authors.lastname: El-Kamah
mesh_terms: D000328:Adult; D002648:Child; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006801:Humans; D008297:Male; D009059:Mouth Diseases / Q000235:genetics* / Q000473:pathology; D010375:Pedigree; D010390:Pemphigoid, Benign Mucous Membrane / Q000235:genetics* / Q000473:pathology; D010641:Phenotype
chemical_list: D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C057615:HLA-DQbeta antigen