title: A case of hypophosphatemic osteomalacia secondary to deferasirox therapy.
abstract: Patients with β-thalassemia major require iron-chelation therapy to avoid the complication of iron overload. Until recently, deferoxamine (DFO) was the major iron chelator used in patients requiring chronic hypertransfusion therapy, but DFO required continuous subcutaneous therapy. The availability of deferasirox (Exjade®), an orally active iron chelator, over the past 4 years represented a necessary alternative for patients requiring chelation therapy. However, there have been increasing reports of proximal renal tubular dysfunction and Fanconi syndrome associated with deferasirox in the literature. We report a case of hypophosphataemic osteomalacia secondary to deferasirox therapy.
authors.affiliation: Prince Henry's Institute and Department of Endocrinology, Melbourne, Australia.
authors.forename: Frances
authors.initials: F
authors.lastname: Milat
authors.forename: Phillip
authors.initials: P
authors.lastname: Wong
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Fuller
authors.forename: Lillian
authors.initials: L
authors.lastname: Johnstone
authors.forename: Peter G
authors.initials: PG
authors.lastname: Kerr
authors.forename: James C G
authors.initials: JC
authors.lastname: Doery
authors.forename: Boyd J
authors.initials: BJ
authors.lastname: Strauss
authors.forename: Donald K
authors.initials: DK
authors.lastname: Bowden
mesh_terms: D000328:Adult; D001565:Benzoates / Q000009:adverse effects*; D015519:Bone Density / Q000187:drug effects; D000077588:Deferasirox; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D017674:Hypophosphatemia / Q000097:blood / Q000139:chemically induced* / Q000150:complications*; D008159:Lumbar Vertebrae / Q000187:drug effects / Q000503:physiopathology; D010018:Osteomalacia / Q000097:blood / Q000139:chemically induced* / Q000150:complications*; D010710:Phosphates / Q000097:blood; D014230:Triazoles / Q000009:adverse effects*
chemical_list: D001565:Benzoates; D010710:Phosphates; D014230:Triazoles; D000077588:Deferasirox