title: Synthesis, Antiviral and Cytotoxic Activities of 2-(2-Phenyl carboxylic acid)-3-Phenylquinazolin -4(3H)-one Derivatives.
abstract: A series of novel 2,3-disubstitutedquinazolin-4(3H)-ones have been synthesized by condensation of 2-substituted benzo[1,3]oxazine-4-ones and anthranilic acid. Synthesized compounds were evaluated for in vitro antiviral activity against HIV, HSV and vaccinia viruses. 5-Bromo-2-(6-bromo-4-oxo-2-phenyl-4H-quinazolin-3-yl)-benzoic acid (MBR2) exhibited distinct antiviral activity against Herpes simplex and vaccinia viruses.
authors.affiliation: Department of Pharmaceutical Chemistry, Devaki Amma Memorial College of Pharmacy, Chelembra, Malapuram - 673 436, India.
authors.forename: P
authors.initials: P
authors.lastname: Selvam
authors.forename: N
authors.initials: N
authors.lastname: Murugesh
authors.forename: M
authors.initials: M
authors.lastname: Chandramohan
authors.forename: C
authors.initials: C
authors.lastname: Pannecouque
authors.forename: E
authors.initials: E
authors.lastname: DE Clercq