title: Insulin resistance and its association with metabolic syndrome components.
abstract: BACKGROUND
  Individuals with insulin resistance are more prone to the development of metabolic syndrome (MS), Type 2 Diabetes Mellitus and Cardiovascular Disease (CVD) OBJECTIVE: To evaluate the association between insulin resistance (IR) and metabolic syndrome components.
  
  
  METHODS
  Cross-sectional study of 196 individuals between 2 and 18 years, treated at the Brazilian Public Healthcare system. The association of IR with the MS components was evaluated by Chi-square test, adopting the Homeostasis model assessment-insulin resistance (HOMA-IR) value > 2.5, and by analysis of variance (ANOVA) and Tukey's test, by comparing the means of the components in the HOMA-IR quartiles. Statistical analysis was performed using SPSS 17.0 software and significance level was set at 5%.
  
  
  RESULTS
  IR was observed in 41.3% of the studied population and was associated with age between 10-18 years (p = 0.002 PR = 3.2), to MS in both sexes [Male (p = 0.022 PR = 3.7) and female (p = 0.007 PR = 2.7)] and altered triglycerides (p = 0.005 PR = 2.9) in females. The mean values of the MS components differed significantly between HOMA-IR quartiles (p <0.01), except for HDL-cholesterol.
  
  
  CONCLUSIONS
  Insulin resistance can be considered a marker of cardiovascular risk.
authors.affiliation: Universidade Estadual da Paraíba, Núcleo de Estudos e Pesquisas Epidemiológicas, Campina Grande, PB, Brazil.
authors.forename: Carla Campos Muniz
authors.initials: CC
authors.lastname: Medeiros
authors.forename: Alessandra Teixeira
authors.initials: AT
authors.lastname: Ramos
authors.forename: Maria Aparecida Alves
authors.initials: MA
authors.lastname: Cardoso
authors.forename: Inácia Sátiro Xavier
authors.initials: IS
authors.lastname: França
authors.forename: Anajás da Silva
authors.initials: Ada S
authors.lastname: Cardoso
authors.forename: Nathalia Costa
authors.initials: NC
authors.lastname: Gonzaga
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000209:etiology; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis* / Q000209:etiology; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D012307:Risk Factors
chemical_list: D015415:Biomarkers