title: Chronic kidney disease--mineral and bone disorder: a complex scenario.
abstract: The chronic kidney disease-bone and mineral disorders (CKD-MBD) represents a dinamic area of research. Recently, new factors such as FGF-23 have been added to the classic list of regulators of bone metabolism, which include calcium, phosphorus, PTH and calcitriol. Vascular calcification, one of the most important complication of CKD-MBD is regulated by a complex variety of&nbsp; promoters and inhibitors. The relationship between vascular calcification, bone loss and mortality, together with the existence of likely common signaling pathways are subject of interesting investigations.
authors.affiliation: Servicio de Nefrología Pediátrica, Hospital Universitario Central de Asturias, Oviedo, Asturias.
authors.forename: N
authors.initials: N
authors.lastname: Mejía
authors.forename: P
authors.initials: P
authors.lastname: Roman-García
authors.forename: A B
authors.initials: AB
authors.lastname: Miar
authors.forename: B
authors.initials: B
authors.lastname: Tavira
authors.forename: J B
authors.initials: JB
authors.lastname: Cannata-Andía
mesh_terms: D001842:Bone and Bones / Q000378:metabolism*; D002117:Calcitriol / Q000502:physiology; D002118:Calcium / Q000378:metabolism; D002908:Chronic Disease; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000209:etiology* / Q000378:metabolism; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000502:physiology; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000209:etiology / Q000378:metabolism; D007674:Kidney Diseases / Q000150:complications* / Q000378:metabolism / Q000401:mortality; D008903:Minerals / Q000378:metabolism*; D010281:Parathyroid Hormone / Q000502:physiology; D010758:Phosphorus / Q000378:metabolism; D061205:Vascular Calcification / Q000209:etiology / Q000378:metabolism
chemical_list: C000717427:FGF23 protein, human; D008903:Minerals; D010281:Parathyroid Hormone; D010758:Phosphorus; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D002117:Calcitriol; D002118:Calcium