title: Increased risk of acute pancreatitis among tetracycline users in a Swedish population-based case-control study.
abstract: OBJECTIVE
  To evaluate the suggested association between tetracycline and acute pancreatitis in a large pharmacoepidemiological study.
  
  
  METHODS
  The use of tetracycline in relation to the risk of acute pancreatitis was examined in a nationwide case-control study of people aged 40-84 years between 2006 and 2008 in Sweden. The Swedish Patient Register was used to identify 6161 cases of first-episode acute pancreatitis. The Register of the Total Population was used to randomly select 61,637 control subjects from the general population using frequency-based density sampling, matched for age, sex, and calendar year. Tetracycline use was defined as 'current', 'recent', 'past' or 'former' if the drug had been dispensed 0-30 days, 31-180 days, 181-365 days or 1-3½ years before the index date, respectively. The risk of acute pancreatitis was estimated by unconditional logistic regression, providing ORs with 95% CIs, adjusted for potential confounding factors.
  
  
  RESULTS
  There was a 60% increased risk of acute pancreatitis among current users of tetracycline after adjustment for potential confounders (OR=1.6, 95% CI 1.2 to 2.1). There was no increased OR for any category of previous use.
  
  
  CONCLUSIONS
  Current use of tetracycline is associated with an increased risk of acute pancreatitis, verifying previous case reports.
authors.affiliation: Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Norra Stationsgatan 67, 2nd floor, Karolinska Institutet, SE-171 76 Stockholm, Sweden. rickard.ljung@ki.se
authors.forename: Rickard
authors.initials: R
authors.lastname: Ljung
authors.forename: Jesper
authors.initials: J
authors.lastname: Lagergren
authors.forename: Tomas S
authors.initials: TS
authors.lastname: Bexelius
authors.forename: Fredrik
authors.initials: F
authors.lastname: Mattsson
authors.forename: Mats
authors.initials: M
authors.lastname: Lindblad
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D016022:Case-Control Studies; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010195:Pancreatitis / Q000139:chemically induced*; D012307:Risk Factors; D013548:Sweden; D013752:Tetracycline / Q000009:adverse effects*
chemical_list: D000900:Anti-Bacterial Agents; D013752:Tetracycline