title: Portal vein embolisation for extended hepatectomy: single-centre experience.
abstract: BACKGROUND
  Portal vein embolisation (PVE) induces contra-lateral liver hypertrophy to facilitate an extended hepatectomy.
  
  
  OBJECTIVE
  This paper aims to analyse our data on PVE and extended hepatectomy. Outcome measures included success of PVE, feasibility of resections, operative morbidity and survival.
  
  
  METHODS
  A retrospective analysis of data collected prospectively on 33 patients (2004-2008) was performed. Survival curves were estimated by the Kaplan-Meier (Breslow) method. Significance was defined as p < 0.05.
  
  
  RESULTS
  A total of 31 patients had successful PVE. There were 24 patients who underwent surgery. Significant hypertrophy of residual liver was noted from 230.15 (pre-embolisation) to 428.50 ml (post-embolisation) (median, p < 0.0001). A total of 16 patients had hepatectomy (14: R0; 2: R1) with a single mortality (6.25%) and 56.25% morbidity, and a median length of stay of 17 days. Median overall survival was 14 (95% CI 7.8-20.2) months. Patients who underwent resection had a median disease-specific survival of 33 (95% CI 4-62) months compared with 8.6 (95% CI 0-19.9) months for patients without resection (p = 0.14). For patients with primary hepato-biliary tumours, the median disease-specific survival was 7.9 (95% CI 4.5-11.3) months compared with a median survival of 19.7 (95% CI 0-42.2) months for patients with metastases (p = 0.07).
  
  
  CONCLUSIONS
  PVE is safe, facilitates R0 resection and offers the best chance of cure, especially for liver metastases.
authors.affiliation: Division of Hepato-biliary and Pancreatic Surgery, Barts and the London HPB Centre, The Royal London Hospital, London, E1 1BB, UK. soumil_v@yahoo.com
authors.forename: Soumil
authors.initials: S
authors.lastname: Vyas
authors.forename: Clare
authors.initials: C
authors.lastname: Bent
authors.forename: Stefano
authors.initials: S
authors.lastname: Partelli
authors.forename: Ajit T
authors.initials: AT
authors.lastname: Abraham
authors.forename: Robert R
authors.initials: RR
authors.lastname: Hutchins
authors.forename: Satyajit
authors.initials: S
authors.lastname: Bhattacharya
authors.forename: Deborah
authors.initials: D
authors.lastname: Low
authors.forename: Tim
authors.initials: T
authors.lastname: Fotheringham
authors.forename: Hemant M
authors.initials: HM
authors.lastname: Kocher
mesh_terms: D004621:Embolization, Therapeutic; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D011169:Portal Vein; D011446:Prospective Studies; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome