title: Enantioselective synthesis of α-deuterium labelled chiral α-amino acids via dynamic kinetic resolution of racemic azlactones.
abstract: Catalytic dynamic kinetic resolution (DKR) of racemic azlactones with EtOD using squaramide-based dimeric cinchona alkaloid organocatalysts is shown to be a highly effective strategy for the preparation of enantiomerically pure α-deuterated chiral α-amino acids.
authors.affiliation: Department of Chemistry, Sungkyunkwan University, Suwon, Gyeonggi 440-746, Korea.
authors.forename: Joong-Suk
authors.initials: JS
authors.lastname: Oh
authors.forename: Kyung Il
authors.initials: KI
authors.lastname: Kim
authors.forename: Choong Eui
authors.initials: CE
authors.lastname: Song
mesh_terms: D000470:Alkaloids / Q000737:chemistry; D000596:Amino Acids / Q000138:chemical synthesis*; D002384:Catalysis; D003903:Deuterium / Q000737:chemistry; D007700:Kinetics; D007783:Lactones / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D000596:Amino Acids; D007783:Lactones; D003903:Deuterium