title: Multimodal functional network connectivity: an EEG-fMRI fusion in network space.
abstract: EEG and fMRI recordings measure the functional activity of multiple coherent networks distributed in the cerebral cortex. Identifying network interaction from the complementary neuroelectric and hemodynamic signals may help to explain the complex relationships between different brain regions. In this paper, multimodal functional network connectivity (mFNC) is proposed for the fusion of EEG and fMRI in network space. First, functional networks (FNs) are extracted using spatial independent component analysis (ICA) in each modality separately. Then the interactions among FNs in each modality are explored by Granger causality analysis (GCA). Finally, fMRI FNs are matched to EEG FNs in the spatial domain using network-based source imaging (NESOI). Investigations of both synthetic and real data demonstrate that mFNC has the potential to reveal the underlying neural networks of each modality separately and in their combination. With mFNC, comprehensive relationships among FNs might be unveiled for the deep exploration of neural activities and metabolic responses in a specific task or neurological state.
authors.affiliation: The Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Lei
authors.forename: Dirk
authors.initials: D
authors.lastname: Ostwald
authors.forename: Jiehui
authors.initials: J
authors.lastname: Hu
authors.forename: Chuan
authors.initials: C
authors.lastname: Qiu
authors.forename: Camillo
authors.initials: C
authors.lastname: Porcaro
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Bagshaw
authors.forename: Dezhong
authors.initials: D
authors.lastname: Yao
mesh_terms: D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods; D003198:Computer Simulation; D004569:Electroencephalography / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008959:Models, Neurological; D009415:Nerve Net / Q000033:anatomy & histology / Q000502:physiology*; D015203:Reproducibility of Results