title: Models for assessing antipsychotics: antagonism of amphetamine-induced hyperactivity and stereotypies in mice.
abstract: All classical antipsychotics, such as chlorpromazine and haloperidol, have potent dopamine receptor-blocking properties. This unit describes the rat anti-Thy-1.1 model of acute proliferative glomerulonephritis for the study of chronic renal insufficiency. A procedure is detailed for the induction of glomerulonephritis in rats as well as measurement of daily urinary excretion of protein, which is a convenient, primary screening tool. The unit also provides methods for assessment of glomerular filtration rate and effective renal plasma flow in anesthetized rats with anti-Thy-1.1-induced renal insufficiency.
authors.affiliation: Phoenix International Pharmacology, Le Kremlin-Bicêtre Cedex, France.
authors.forename: S
authors.initials: S
authors.lastname: Roux
authors.forename: A M
authors.initials: AM
authors.lastname: Hay
authors.forename: R D
authors.initials: RD
authors.lastname: Porsolt
mesh_terms: D000661:Amphetamine / Q000633:toxicity*; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D006948:Hyperkinesis / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D051379:Mice; D019956:Stereotypic Movement Disorder / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D014150:Antipsychotic Agents; D000661:Amphetamine