title: The role of plasma N-terminal pro-B-type natriuretic peptide in predicting the severity of transient tachypnea of the newborn.
abstract: OBJECTIVE
  Transient tachypnea of the newborn (TTN) is a consequence of inadequate neonatal lung fluid clearance. Natriuretic peptides play an important role in the regulation of extracellular fluid volume. The aim of the study was to investigate the relation between plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels and TTN, and to find out its role in predicting disease severity.
  
  
  METHODS
  A prospective controlled study involving 67 infants with TTN and 33 controls ≥34 weeks gestational age was conducted. Study and control groups were compared for plasma NT-proBNP levels measured on the 6th, 24th, 72nd and 120th hours of life. Cardiac systolic functions were evaluated by echocardiography.
  
  
  RESULTS
  NT-proBNP levels were significantly higher in neonates with TTN compared to controls at 6th, 24th, 72nd and 120th hours (p<0.001). NT-proBNP levels at 24th and 72nd hours were significantly higher in infants with prolonged tachypnea (p=0.007 and p=0.03) and in those who required respiratory support (p=0.006 and p<0.001). Tachypnea duration was correlated with NT-proBNP levels at 24h (r=0.41, p=0.001). At a cut-off value of 6575 pg/ml, NT-proBNP had a sensitivity of 85% and specificity of 64% to predict mechanical ventilation requirement. Cardiac systolic functions were normal in all TTN patients.
  
  
  CONCLUSIONS
  Plasma NT-proBNP levels are increased in neonates with TTN. Measurement of plasma NT-proBNP can be useful for predicting infants who will have prolonged tachypnea and mechanical ventilation requirement.
authors.affiliation: Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey. drozgegenc@yahoo.com.tr
authors.forename: Ozge
authors.initials: O
authors.lastname: Aydemir
authors.forename: Cumhur
authors.initials: C
authors.lastname: Aydemir
authors.forename: Yusuf Unal
authors.initials: YU
authors.lastname: Sarikabadayi
authors.forename: Nahide
authors.initials: N
authors.lastname: Altug
authors.forename: Omer
authors.initials: O
authors.lastname: Erdeve
authors.forename: Nurdan
authors.initials: N
authors.lastname: Uras
authors.forename: Serife Suna
authors.initials: SS
authors.lastname: Oguz
authors.forename: Ugur
authors.initials: U
authors.lastname: Dilmen
mesh_terms: D015415:Biomarkers / Q000097:blood; D001724:Birth Weight; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D059245:Transient Tachypnea of the Newborn / Q000097:blood / Q000175:diagnosis*
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain