title: Side effects of benznidazole treatment in a cohort of patients with Chagas disease in non-endemic country.
abstract: Chagas disease is a disease endemic in Latin America, caused by the parasite Trypanosoma cruzi. Benznidazole is the most commonly used drug for the etiological treatment of the disease although its effectiveness varies according to the phase of the same and toxic side effects are frequent. This prospective study describes the side effects of benznidazole treatment of a cohort of 373 chronic patients. Of these 40.2% presented adverse reactions. The most frequent side effect were dermatological reactions 32.4% (121 of 373) followed by digestive intolerance 9.1% (34 of 373). Surprisingly, three cases of migratory arthritis were observed. Patients treated with benznidazole must be followed up so that the long term incidence of side effects can be studied.
authors.affiliation: Unidad Regional de Medicina Tropical, Servicio de Microbiología, Hospital Universitario Virgen de la Arrixaca, Carretera Madrid-Cartagena, El Palmar Murcia, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Carrilero
authors.forename: L
authors.initials: L
authors.lastname: Murcia
authors.forename: L
authors.initials: L
authors.lastname: Martínez-Lage
authors.forename: M
authors.initials: M
authors.lastname: Segovia
mesh_terms: D000328:Adult; D001168:Arthritis / Q000139:chemically induced / Q000453:epidemiology; D014355:Chagas Disease / Q000150:complications* / Q000188:drug therapy; D015331:Cohort Studies; D003875:Drug Eruptions / Q000453:epidemiology; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009593:Nitroimidazoles / Q000009:adverse effects* / Q000627:therapeutic use; D011446:Prospective Studies; D013030:Spain; D014344:Trypanocidal Agents / Q000009:adverse effects* / Q000627:therapeutic use; D014349:Trypanosoma cruzi
chemical_list: D009593:Nitroimidazoles; D014344:Trypanocidal Agents; C009999:benzonidazole