title: Protective properties of five newly synthesized cyclic compounds against sodium azide and N-methyl-N'-nitro-N-nitrosoguanidine genotoxicity.
abstract: The current study aims to determine the antimutagenic potential of five newly synthesized cyclic compounds against the genotoxic agents sodium azide (NaN₃) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The mutant bacterial tester strains were NaN₃-sensitive Salmonella typhimurium TA1535 and MNNG-sensitive Escherichia coli WP2uvrA. According to the results, all the test compounds showed significant antimutagenic activity. The inhibition rates ranged from 26.05% (Compound 4-1 µg/plate) to 68.54% (Compound 5-0.01 µg/plate) for NaN₃ and from 32.44% (Compound 3-1 µg/plate) to 60.77% (Compound 5-1 µg/plate) for MNNG genotoxicity. Moreover, the mutagenic potential of the test compounds was investigated using the same strains. The results showed that all the test compounds do not have mutagenic potential on the bacterial strains at the tested concentrations. Thus, the findings of the present study give valuable information about chemical prevention from NaN₃ and MNNG genotoxicity.
authors.affiliation: Department of Chemistry, Yildiz Technical University, Istanbul, Turkey.
authors.forename: Kadir
authors.initials: K
authors.lastname: Turhan
authors.forename: S Arda
authors.initials: SA
authors.lastname: Ozturkcan
authors.forename: Zuhal
authors.initials: Z
authors.lastname: Turgut
authors.forename: Mehmet
authors.initials: M
authors.lastname: Karadayi
authors.forename: Medine
authors.initials: M
authors.lastname: Gulluce
mesh_terms: D000704:Analysis of Variance; D016587:Antimutagenic Agents / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics; D006571:Heterocyclic Compounds / Q000494:pharmacology*; D008769:Methylnitronitrosoguanidine / Q000633:toxicity*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D009154:Mutation / Q000187:drug effects / Q000235:genetics; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D019810:Sodium Azide / Q000633:toxicity*
chemical_list: D016587:Antimutagenic Agents; D006571:Heterocyclic Compounds; D009153:Mutagens; D008769:Methylnitronitrosoguanidine; D019810:Sodium Azide