title: Porcine intestinal epithelial responses to Campylobacter infection.
abstract: Campylobacter infection is estimated to cause diarrhoea in 1% of the population of developed countries every year, but our understanding of this disease has been hampered by a lack of a suitable animal model. Colostrum-deprived piglets have been suggested as models since they produce similar clinical signs to humans when infected but little information currently exists regarding the response of this species to Campylobacter at cellular and molecular level. This study shows that intestinal epithelial cells from both species respond in a similar manner to Campylobacter infection regarding invasion, induction of innate immune response and effect on barrier function.
authors.affiliation: Division of Veterinary Pathology, Infection and Immunity, School of Clinical Veterinary Science, University of Bristol, Langford House, Langford, North Somerset, BS40 5DU, UK. helsmurphy@hotmail.com
authors.forename: H
authors.initials: H
authors.lastname: Murphy
authors.forename: T
authors.initials: T
authors.lastname: Cogan
authors.forename: R
authors.initials: R
authors.lastname: Hughes
authors.forename: T
authors.initials: T
authors.lastname: Humphrey
mesh_terms: D000818:Animals; D017000:Campylobacter coli / Q000472:pathogenicity*; D016123:Campylobacter jejuni / Q000472:pathogenicity*; D016923:Cell Death / Q000276:immunology; D002460:Cell Line; D006801:Humans; D016209:Interleukin-8 / Q000276:immunology / Q000378:metabolism; D007413:Intestinal Mucosa / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D013552:Swine; D019108:Tight Junctions / Q000648:ultrastructure; D000097782:NF-kappaB-Inducing Kinase
chemical_list: D016209:Interleukin-8; D017346:Protein Serine-Threonine Kinases; D000097782:NF-kappaB-Inducing Kinase