title: Long-term efficacy and safety of the small-sized β2-microglobulin adsorption column for dialysis-related amyloidosis.
abstract: Dialysis-related amyloidosis (DRA) is one of the major complications often seen in long-term dialysis patients, and is one of the factors that decreases quality of life. β2-microglobulin (β2-m) is considered to be a major pathogenic factor in dialysis-related amyloidosis. The Lixelle adsorbent column, with various capacities, has been developed to adsorb β2-m from the circulating blood of patients with dialysis-related amyloidosis. Using a minimum type of β2-m-adsorbing column (Lixelle S-15), we evaluated its therapeutic efficacy and safety in dialysis patients. Seventeen hemodialysis patients with DRA were treated with the S-15 column for one year. Treatment was performed three times a week in this study. During the study period, pinch strength, visual analog scale for joint pain, and activities of daily living were evaluated every three months, and blood sampling was performed every six months. After one year's treatment with the S-15 column, the β2-m level decreased from 29.3±9.6mg/L to 24.7±5.1mg/L (P<0.05), and the high sensitive C-reactive protein level decreased from 2996±4380ng/mL to 1292±1774ng/mL. After one year of S-15 column use, pinch strength increased from 5.9±3.0pounds to 7.2±3.2pounds (P<0.05), and the visual analog scale for joint pain and activities of daily living score also improved. Long-term use of the Lixelle S-15 column is safe and effective for improvement of quality of life in chronic dialysis patients. Improvement of chronic inflammation may be one of the mechanisms through which the beneficial effects of the column is effected.
authors.affiliation: Division of Nephrology, Dialysis and Apheresis, Yokohama City University Medical Center, 45-7, Urafune-cho, Minami-ku, Yokohama 232-0024, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Nobuhito
authors.initials: N
authors.lastname: Hirawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Nariaki
authors.initials: N
authors.lastname: Ogawa
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Takeda
authors.forename: Ken
authors.initials: K
authors.lastname: Shibuya
authors.forename: Kimiko
authors.initials: K
authors.lastname: Kawahara
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Kojima
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Dobashi
authors.forename: Megumi
authors.initials: M
authors.lastname: Fujita
authors.forename: Kengo
authors.initials: K
authors.lastname: Azusima
authors.forename: Nobuko
authors.initials: N
authors.lastname: Miyazaki
authors.forename: Mayumi
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Chinatsu
authors.initials: C
authors.lastname: Kobayashi
authors.forename: Akira
authors.initials: A
authors.lastname: Fujiwara
authors.forename: Jun
authors.initials: J
authors.lastname: Yuto
authors.forename: Sanae
authors.initials: S
authors.lastname: Saka
authors.forename: Keisuke
authors.initials: K
authors.lastname: Yatsu
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Toya
authors.forename: Gen
authors.initials: G
authors.lastname: Yasuda
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Ohnishi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Umemura
mesh_terms: D000203:Activities of Daily Living; D000327:Adsorption; D000686:Amyloidosis / Q000209:etiology / Q000628:therapy*; D018771:Arthralgia / Q000209:etiology; D001781:Blood Component Removal / Q000379:methods*; D002097:C-Reactive Protein / Q000378:metabolism; D004867:Equipment Design; D005260:Female; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D011788:Quality of Life; D006435:Renal Dialysis / Q000009:adverse effects*; D013997:Time Factors; D016896:Treatment Outcome; D001613:beta 2-Microglobulin / Q000097:blood*
chemical_list: D001613:beta 2-Microglobulin; D002097:C-Reactive Protein