title: The oral iron chelator deferasirox induces apoptosis in myeloid leukemia cells by targeting caspase.
authors.affiliation: Graduate School of Medicine, Korea University College of Medicine, Seoul, South Korea.
authors.forename: Jung-Lim
authors.initials: JL
authors.lastname: Kim
authors.forename: Han-Na
authors.initials: HN
authors.lastname: Kang
authors.forename: Myoung Hee
authors.initials: MH
authors.lastname: Kang
authors.forename: Young A
authors.initials: YA
authors.lastname: Yoo
authors.forename: Jun Suk
authors.initials: JS
authors.lastname: Kim
authors.forename: Chul Won
authors.initials: CW
authors.lastname: Choi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects*; D001562:Benzimidazoles; D001565:Benzoates / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D020169:Caspases / Q000378:metabolism*; D002453:Cell Cycle / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D000077588:Deferasirox; D004789:Enzyme Activation / Q000187:drug effects; D018922:HL-60 Cells; D006801:Humans; D007274:Injections, Intraperitoneal; D007502:Iron Chelating Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D007951:Leukemia, Myeloid / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D009363:Neoplasm Proteins / Q000378:metabolism*; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D059748:Proteolysis; D014230:Triazoles / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D047368:Tumor Burden / Q000187:drug effects; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D001562:Benzimidazoles; D001565:Benzoates; D007502:Iron Chelating Agents; D009363:Neoplasm Proteins; D014230:Triazoles; C043345:emedastine; D011065:Poly(ADP-ribose) Polymerases; D020169:Caspases; D000077588:Deferasirox