title: Neuraminidase inhibitory polyketides from the marine-derived fungus Phoma herbarum.
abstract: Two new polyketides, arthropsadiol C (1) and massarilactone H (2), together with six known derivatives (3-8) were isolated from the culture broth of the marine-derived fungus Phoma herbarum. Their structures were elucidated on the basis of spectroscopic methods, including 2D NMR techniques. Compounds 2, 4, 5, and 8 showed moderate neuraminidase inhibitory activity with IC(50) values ranging from 4.15 to 9.16 µM.
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.
authors.forename: Gao Fei
authors.initials: GF
authors.lastname: Zhang
authors.forename: Wen Bo
authors.initials: WB
authors.lastname: Han
authors.forename: Jiang Tao
authors.initials: JT
authors.lastname: Cui
authors.forename: Seik Weng
authors.initials: SW
authors.lastname: Ng
authors.forename: Zhi Kai
authors.initials: ZK
authors.lastname: Guo
authors.forename: Ren Xiang
authors.initials: RX
authors.lastname: Tan
authors.forename: Hui Ming
authors.initials: HM
authors.lastname: Ge
mesh_terms: D001203:Ascomycota / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D001688:Biological Products; D004791:Enzyme Inhibitors; D061065:Polyketides; C572582:arthropsadiol C; C572584:massarilactone H; D009439:Neuraminidase