title: Metabolomics in paediatric respiratory diseases and bronchiolitis.
abstract: The metabolic study of an organism may make it possible to monitor, through the metabolites,the physiology and/or pathology of the organism itself. Metabolomics, in the strictest sense, "the set of metabolites, the final products of the genetic expression". Most clinical chemistry tests available today rely on old technologies that measure only a single chemical in blood, urine or other biofluids, and these tests are neither sensitive nor specific for any particular disease. Metabolomics offers a holistic approach to systems medicine, with the promise to enhance clinical chemistry diagnostics in several pathologic conditions. The present review covers the application of clinical metabolomics in three different areas of respiratory diseases in pediatrics: asthma, pneumonia and bronchiolitis. Comparison between two 1H-NMR urine spectra by two bronchiolitis patients are also presented.
authors.affiliation: Neonatal Intensive Care Unit, Puericultura Institute and Neonatal Section, University of Cagliari, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Atzei
authors.forename: Luigi
authors.initials: L
authors.lastname: Atzori
authors.forename: Corrado
authors.initials: C
authors.lastname: Moretti
authors.forename: Luigi
authors.initials: L
authors.lastname: Barberini
authors.forename: Antonio
authors.initials: A
authors.lastname: Noto
authors.forename: Giovanni
authors.initials: G
authors.lastname: Ottonello
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Pusceddu
authors.forename: Vassilios
authors.initials: V
authors.lastname: Fanos
mesh_terms: D001249:Asthma / Q000175:diagnosis / Q000378:metabolism; D015415:Biomarkers / Q000032:analysis; D001826:Body Fluids / Q000737:chemistry; D001988:Bronchiolitis / Q000175:diagnosis / Q000378:metabolism*; D002648:Child; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D055432:Metabolomics / Q000379:methods; D012140:Respiratory Tract Diseases / Q000175:diagnosis / Q000378:metabolism*
chemical_list: D015415:Biomarkers