title: [A case of symptomatic pituitary metastases from renal cell carcinoma].
abstract: Symptomatic metastases to the pituitary from renal cell carcinoma are rare. We present a case of pituitary metastases from renal cell carcinoma showing panhypopituitarism. A 50-year-old man who had renal cell carcinoma with distant metastases in skin, bone and lymph nodes was referred to our department. Clinically he showed severe cognitive function disorder. Endocrinological evaluation revealed central adrenal and gonadal insufficiencies. Brain magnetic resonance imaging demonstrated a hemorrhagic mass in left frontal lobe and a sellar mass with supra sellar cistern extension. After hormonal replacement and surgical removal of the frontal tumor, he immediately recovered from his cognitive function disorder. Subsequently, whole brain radiotherapy for metastatic pituitary tumor was performed. At present, he is being treated with molecular targeting drugs for other distant metastases and he presents no neurological deficit. Palliative therapy for CNS metastases from renal cell carcinoma may result in better quality of life for patients with advanced stage of renal cell carcinoma.
authors.affiliation: Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Japan.
authors.forename: Yuuta
authors.initials: Y
authors.lastname: Kamoshima
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Terasaka
authors.forename: Shuji
authors.initials: S
authors.lastname: Hamauchi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Shogo
authors.initials: S
authors.lastname: Endo
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kanno
authors.forename: Kimihiko
authors.initials: K
authors.lastname: Kimachi
authors.forename: Kiyohiro
authors.initials: K
authors.lastname: Houkin
mesh_terms: D002292:Carcinoma, Renal Cell / Q000473:pathology*; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy