title: [Local injection of gentamycin for female urethral syndrome: a clinical study].
abstract: OBJECTIVE
  To observe the therapeutic effect of local antibiotic injection into the female prostate on female urethral syndrome (FUS), and search for an effective treatment for this disease.
  
  
  METHODS
  This study included 163 FUS patients treated in the out-patient department between July 2009 and December 2010. According to the visiting order, the patients were randomly assigned to Groups A (n = 58), B (n = 55) and C (n = 50). All underwent routine treatment. Inaddition Group A received local injection of 2 ml of 80 000 U gentamycin + 2 ml of lidocaine, and Group B 2 ml of normal saline + 2 ml of lidocaine, both injected into the distal segment of the urethral back wall where the female prostate is located, twice a week for 3 weeks. The therapeutic effects were evaluated according to the changes of the patients' independent symptom scores at 2 and 4 weeks after the treatment. Disappearance of the symptoms was considered as "curative" , > 1/2 reduction in the symptom score as "obviously effective", 1/2 - > 1/4 reduction in the symptom score as "effective", and < 1/4 reduction or increase in the symptom score as "ineffective".
  
  
  RESULTS
  At 2 weeks after the treatment, the total effectiveness rate was significantly higher in Group A (77.5%) than in B (67.3%) and C (68.0%) (P < 0.05), but with no statistically significant difference between B and C (P > 0.05). At 4 weeks, the total effectiveness rate of Group A was slightly decreased, but still remarkably higher than that of group B or C (P < 0.05).
  
  
  CONCLUSIONS
  Local injection of gentamycin into the female prostate is effective for the treatment of female urethral syndrome.
authors.affiliation: Department of Urology, Humen Hospital, Dongguan, Guangdong 523902, China. dxm42003@yahoo.com.cn
authors.forename: Xin-Min
authors.initials: XM
authors.lastname: Ding
authors.forename: Guo-Hua
authors.initials: GH
authors.lastname: Jiang
authors.forename: Hong-Bo
authors.initials: HB
authors.lastname: Wen
authors.forename: Jin-Yuan
authors.initials: JY
authors.lastname: He
authors.forename: Guan-Hao
authors.initials: GH
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007267:Injections; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome; D014522:Urethral Diseases / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D005839:Gentamicins