title: Synthesis of 2H-indazoles by the [3 + 2] dipolar cycloaddition of sydnones with arynes.
abstract: A rapid and efficient synthesis of 2H-indazoles has been developed using a [3 + 2] dipolar cycloaddition of sydnones and arynes. A series of 2H-indazoles have been prepared in good to excellent yields using this protocol, and subsequent Pd-catalyzed coupling reactions can be applied to the halogenated products to generate a structurally diverse library of indazoles.
authors.affiliation: Department of Chemistry, Iowa State University, Ames, Iowa 50011, United States.
authors.forename: Yuesi
authors.initials: Y
authors.lastname: Fang
authors.forename: Chunrui
authors.initials: C
authors.lastname: Wu
authors.forename: Richard C
authors.initials: RC
authors.lastname: Larock
authors.forename: Feng
authors.initials: F
authors.lastname: Shi
mesh_terms: D002384:Catalysis; D006846:Hydrocarbons, Halogenated / Q000737:chemistry; D007191:Indazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D013237:Stereoisomerism; D013558:Sydnones / Q000737:chemistry*
chemical_list: D006846:Hydrocarbons, Halogenated; D007191:Indazoles; D013558:Sydnones; D010165:Palladium