title: Changes in incidence, survival and mortality of prostate cancer in Europe and the United States in the PSA era: additional diagnoses and avoided deaths.
abstract: BACKGROUND
  We describe changes in prostate cancer incidence, survival and mortality and the resulting impact in additional diagnoses and avoided deaths in European areas and the United States.
  
  
  METHODS
  Using data from 12 European cancer registries and the Surveillance, Epidemiology and End Results program, we describe changes in prostate cancer epidemiology between the beginning of the PSA era (USA: 1985-1989, Europe: 1990-1994) and 2002-2006 among patients aged 40-64, 65-74, and 75+. Additionally, we examine changes in yearly numbers of diagnoses and deaths and variation in male life expectancy.
  
  
  RESULTS
  Incidence and survival, particularly among patients aged <75, increased dramatically, yet both remain (with few exceptions in incidence) lower in Europe than in the United States. Mortality reductions, ongoing since the mid/late 1990 s, were more consistent in the United States, had a distressingly small absolute impact among patients aged 40-64 and the largest absolute impact among those aged 75+. Overall ratios of additional diagnoses/avoided deaths varied between 3.6 and 27.6, suggesting large differences in the actual impact of prostate cancer incidence and mortality changes. Ten years of remaining life expectancy was reached between 68 and 76 years.
  
  
  CONCLUSIONS
  Policies reflecting variation in population life expectancy, testing preferences, decision aids and guidelines for surveillance-based management are urgently needed.
authors.affiliation: Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Neppl-Huber
authors.affiliation: Tuscany Cancer Registry, Clinical and Descriptive Epidemiology Unit, CSPO, Florence, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Zappa
authors.affiliation: Department of Public Health, Erasmus MC Rotterdam, Rotterdam, The Netherlands.
authors.forename: J W
authors.initials: JW
authors.lastname: Coebergh
authors.affiliation: Geneva Cancer Registry, Geneva, Switzerland.
authors.forename: E
authors.initials: E
authors.lastname: Rapiti
authors.affiliation: Cracow Cancer Registry, Cracow, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Rachtan
authors.affiliation: Saarland Cancer Registry, Saarbrücken, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Holleczek
authors.affiliation: Piedmont Cancer Registry, Turin, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Rosso
authors.affiliation: Department of Epidemiology and Biostatistics, National Institute for Health Development, Tallinn, Estonia.
authors.forename: T
authors.initials: T
authors.lastname: Aareleid
authors.affiliation: Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Brenner
authors.affiliation: Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany. Electronic address: a.gondos@dkfz.de.
authors.forename: A
authors.initials: A
authors.lastname: Gondos
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality*; D002423:Cause of Death / Q000639:trends; D003940:Diagnostic Techniques, Endocrine / Q000706:statistics & numerical data / Q000639:trends; D005060:Europe / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008403:Mass Screening / Q000379:methods / Q000706:statistics & numerical data / Q000639:trends*; D008495:Medical Oncology / Q000379:methods / Q000639:trends; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000032:analysis*; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality*; D016019:Survival Analysis; D015996:Survival Rate / Q000639:trends; D014481:United States / Q000453:epidemiology
chemical_list: D017430:Prostate-Specific Antigen