title: Leiomyosarcomas of the oral cavity: report of a radiation-associated and a metastatic case.
abstract: BACKGROUND
  Leiomyosarcoma is rare in the oral cavity, where it may arise as primary, radiation-associated, or metastatic tumor. This article reports two cases of oral leiomyosarcoma, discussing the range of clinicopathological features and the significance of these presentations.
  
  
  METHODS
  One case is a radiation-associated leiomyosarcoma arising in the tongue of a 71-year-old male occurring 22 years after radiation therapy for tonsil squamous cell carcinoma that was surgically treated. The other one is a mandible metastasis from a retroperitoneal widespread leiomyosarcoma in a 69-year-old man, who was treated by surgery and chemotherapy but died from the disease.
  
  
  CONCLUSIONS
  Post-radiotherapy sarcomas of the oral cavity and oral metastasis from soft tissue sarcomas are very uncommon, but based on patient's clinical history, they should be considered by oral health care providers in order to allow an early diagnosis and proper and timely management. Finally, to the best of our knowledge, this seems to be the first reported case of tongue leiomyosarcoma arising in a previously irradiated field.
authors.affiliation: Oral Pathology, School of Dentistry, Fluminense Federal University, Rua Doutor Silvio Henrique Braune, 22-Centro, CEP: 28625-650, Nova Friburgo, Rio de Janiero, Brazil. rebecadesa@gmail.com
authors.forename: Rebeca Souza
authors.initials: RS
authors.lastname: Azevedo
authors.forename: Fábio Ramôa
authors.initials: FR
authors.lastname: Pires
authors.forename: Adriele Ferreira
authors.initials: AF
authors.lastname: Gouvêa
authors.forename: Márcio Ajudarte
authors.initials: MA
authors.lastname: Lopes
authors.forename: Jacks
authors.initials: J
authors.lastname: Jorge
mesh_terms: D000368:Aged; D000539:Alveolar Process / Q000473:pathology / Q000601:surgery; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D018450:Disease Progression; D017809:Fatal Outcome; D005500:Follow-Up Studies; D006801:Humans; D007890:Leiomyosarcoma / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary; D008297:Male; D008339:Mandibular Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D012186:Retroperitoneal Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D014059:Tongue / Q000473:pathology / Q000601:surgery; D014062:Tongue Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D014067:Tonsillar Neoplasms / Q000532:radiotherapy*
chemical_list: D014408:Biomarkers, Tumor