title: G501C polymorphism of the  oxidized LDL receptor gene is associated with albuminuria in Chinese essential  hypertension patients.
abstract: Albuminuria  is an independent predictor of renal and cardiovascular complications in  hypertensive subjects. We previously showed that lectin-like oxidized low  density lipoprotein receptor 1 (OLR-1) polymorphisms at G501C are associated  with susceptibility to essential hypertension and serum C-reactive protein  levels. We have now investigated a possible association between OLR-1  polymorphisms at G501C, genotyped by PCR-RFLP, and severity of albuminuria in  307 hypertensive Chinese subjects and 225 age- and sex-matched controls. Urine albumin  concentration /urine creatinine concentrations (ACR) were measured to evaluate  the severity of albuminuria. Hypertensive subjects had a significantly higher  frequency of the CC genotype and the C allele of the OLR-1 polymorphism than  controls; this was also true for . hypertensive subjects with macroalbuinuria  and microalbuminuria compared to those with normoalbuminuria. The mean ACR  levels and mean serum C-reactive protein levels in CC carriers were  significantly higher than in GG and GC carriers. There was a significant,  positive correlation between serum hs-C-reactive protein levels and ACR levels.  We conclude that OLR-1 polymorphisms at G501C affect the severity of  albuminuria in essential hypertension patients.
authors.affiliation: Department of Cardiology, Hangzhou First Municipal Hospital & Hangzhou Hospital, Nanjing Medical University, Hangzhou, China beckhxw007@yahoo.com.cn.
authors.forename: X W
authors.initials: XW
authors.lastname: Hou
authors.forename: R Q
authors.initials: RQ
authors.lastname: Yang
authors.forename: Y G
authors.initials: YG
authors.lastname: Zhong
authors.forename: W
authors.initials: W
authors.lastname: Gao
authors.forename: S P
authors.initials: SP
authors.lastname: Sun
authors.forename: N F
authors.initials: NF
authors.lastname: Wang