title: BRCA1 is required for postreplication repair after UV-induced DNA damage.
abstract: BRCA1 contributes to the response to UV irradiation. Utilizing its BRCT motifs, it is recruited during S/G2 to UV-damaged sites in a DNA replication-dependent but nucleotide excision repair (NER)-independent manner. More specifically, at UV-stalled replication forks, it promotes photoproduct excision, suppression of translesion synthesis, and the localization and activation of replication factor C complex (RFC) subunits. The last function, in turn, triggers post-UV checkpoint activation and postreplicative repair. These BRCA1 functions differ from those required for DSBR.
authors.affiliation: Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Shailja
authors.initials: S
authors.lastname: Pathania
authors.forename: Jenna
authors.initials: J
authors.lastname: Nguyen
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Hill
authors.forename: Ralph
authors.initials: R
authors.lastname: Scully
authors.forename: Guillaume O
authors.initials: GO
authors.lastname: Adelmant
authors.forename: Jarrod A
authors.initials: JA
authors.lastname: Marto
authors.forename: Jean
authors.initials: J
authors.lastname: Feunteun
authors.forename: David M
authors.initials: DM
authors.lastname: Livingston
mesh_terms: D019313:BRCA1 Protein / Q000235:genetics / Q000378:metabolism*; D002460:Cell Line; D053903:DNA Breaks, Double-Stranded; D004249:DNA Damage; D004260:DNA Repair / Q000502:physiology; D004261:DNA Replication; D006801:Humans; D051818:Replication Protein C / Q000235:genetics / Q000378:metabolism; D014466:Ultraviolet Rays
chemical_list: D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D051818:Replication Protein C