title: Association between promoter polymorphisms of the LIFR gene and schizophrenia             with persecutory delusion in a Korean population.
abstract: Schizophrenia has been associated with an imbalance in inflammatory cytokines.             Leukemia inhibitory factor receptor α (LIFR) is an integral component of the glycoprotein             130-LIFR signaling complex, which participates in signal transduction by members             of the interleukin (IL)-6 cytokine family. The aim of this study was to investigate             whether genetic polymorphisms of the LIFR gene are associated with schizophrenia             in the Korean population. We also explored possible associations between the polymorphisms             and the clinical symptoms of schizophrenia. We selected three single nucleotide             polymorphisms (SNPs) (rs2071237 -200C/G, rs2071236 -254C/T and rs6862038 -962A/G)             on the promoter region of the LIFR gene and recruited 204 schizophrenia patients             and 367 control subjects from the Korean population. All patients were evaluated             according to the Operational Criteria Checklist for Psychotic Illness. SNP genotyping             was performed by direct sequencing. An analysis of multiple logistic regression             models (co-dominant 1, co-dominant 2, dominant, recessive and overdominant) was             performed to evaluate odds ratios (ORs), 95% confidence intervals (CIs) and p-values.             No significant difference was revealed between schizophrenia patients and controls.             However, a significant association was detected between the LIFR gene polymorphisms             and schizophrenia patients with persecutory delusion (rs2071236, OR=2.18, 95%             CI=1.20-3.94, P=0.009 in the overdominant model; rs6862038, OR=2.08, 95% CI=1.16-3.74,             P=0.013 in the overdominant model). The present study suggests that the LIFR gene             may be related to schizophrenia with persecutory delusion in the Korean population.
authors.affiliation: Department of Neuropsychiatry, School of Medicine, Kyung Hee                     University, Dongdaemun-gu, Seoul 130-702, Republic of Korea.
authors.forename: Won Sub
authors.initials: WS
authors.lastname: Kang
authors.forename: Su Kang
authors.initials: SK
authors.lastname: Kim
authors.forename: Jin Kyung
authors.initials: JK
authors.lastname: Park
authors.forename: Ah Rang
authors.initials: AR
authors.lastname: Cho
authors.forename: Hae Jeong
authors.initials: HJ
authors.lastname: Park
authors.forename: Joo-Ho
authors.initials: JH
authors.lastname: Chung
authors.forename: Jong Woo
authors.initials: JW
authors.lastname: Kim
mesh_terms: D000328:Adult; D003702:Delusions / Q000150:complications* / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D053680:Leukemia Inhibitory Factor Receptor alpha Subunit / Q000235:genetics*; D016015:Logistic Models; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*; D056910:Republic of Korea; D012559:Schizophrenia / Q000150:complications* / Q000235:genetics*; D017422:Sequence Analysis, DNA
chemical_list: D053680:Leukemia Inhibitory Factor Receptor alpha Subunit