title: Scope of the organocatalysed asymmetric reductive amination of ketones with trichlorosilane.
abstract: A highly active organocatalyst has been shown to affect the asymmetric reductive amination of ketones producing both aromatic and aliphatic amines. At 1 mol% catalyst loading, a series of structurally diverse chiral amines were quickly and economically prepared with good enantioselectivity and generally useful yield. The efficient synthesis of the calcimimetic (+)-NPS R-568 (67%, 89% ee) demonstrated the synthetic applicability of this methodology.
authors.affiliation: Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, UK S3 7HF.
authors.forename: François-Moana
authors.initials: FM
authors.lastname: Gautier
authors.forename: Simon
authors.initials: S
authors.lastname: Jones
authors.forename: Xianfu
authors.initials: X
authors.lastname: Li
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Martin
mesh_terms: D000586:Amination; D000588:Amines / Q000032:analysis / Q000138:chemical synthesis*; D002384:Catalysis; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D007659:Ketones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012821:Silanes / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000588:Amines; D007659:Ketones; D012821:Silanes; C065893:trichlorosilane