title: Pituitary function impairment after moderate traumatic brain injury.
abstract: To determine the prevalence of pituitary hormone deficiencies after moderate traumatic brain injury (TBI). We conducted a prospective cohort and included 75 patients with moderate TBI with GCS between 9 and 13 who referred to emergency department of Shariati Hospital, Tehran/Iran, during 2004-2007. Pituitary hormones were assessed 3 and 6 months after injury. In 3(rd) month post-injury, 39 cases had not any pituitary dysfunction; however, deficiencies in one, two and three of the pituitary hormones were found in 26, 8 and 2 patients, respectively. Twenty one patients showed a deficiency in one of the pituitary hormones and only one case with deficiency of two after 6 months. The most prevalent changes occur in IGF-1 and LH/FSH after moderate TBI. However, the whole deficiencies decrease over the time.
authors.affiliation: Department of Neurosurgery, School of Medicine, Tehran University of Medical Sciences, Iran.
authors.forename: Mohammad Reza Hadji
authors.initials: MR
authors.lastname: Abadi
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ghodsi
authors.forename: Masoud
authors.initials: M
authors.lastname: Merazin
authors.forename: Hadi
authors.initials: H
authors.lastname: Roozbeh
mesh_terms: D000293:Adolescent; D000328:Adult; D001930:Brain Injuries / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000378:metabolism / Q000503:physiopathology*; D010907:Pituitary Hormones / Q000378:metabolism; D011446:Prospective Studies; D012720:Severity of Illness Index
chemical_list: D010907:Pituitary Hormones