title: [Role of uric acid in development of essential hypertension: modern conceptions].
abstract: The article deals with current studies on the role of uric acid (UA) in development of cardiovascular diseases. The results of large prospective trials are presented which have revealed a pathogenetic role of UA in development of essential hypertension. Clinical trials demonstrated elevated concentrations of UA in hypertensive patients. Experimental evidence suggests UA involvement in the processes of nonspecific inflammation, oxidant stress, endothelial dysfunction. It is shown that elevated UA levels in blood serum lead to affection of target organs.
authors.forename: O V
authors.initials: OV
authors.lastname: Polovitkina
authors.forename: E V
authors.initials: EV
authors.lastname: Oshchepkova
authors.forename: V A
authors.initials: VA
authors.lastname: Dmitriev
authors.forename: V N
authors.initials: VN
authors.lastname: Titov
mesh_terms: D000818:Animals; D004730:Endothelium, Vascular / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000209:etiology* / Q000378:metabolism; D018384:Oxidative Stress; D014527:Uric Acid / Q000097:blood / Q000378:metabolism*
chemical_list: D014527:Uric Acid