title: Diterpenoids from the freshwater green algae Rhizoclonium hieroglyphicum with antibacterial activity.
abstract: Three new isopimarane diterpenes 7β-hydroxy-19α-methylmalonyloxy-isopimara-8(14),15-diene (1), 7β-hydroxy-14-oxo-isopimara-8(9),15-dien-19oic acid (2), and 7β-hydroxy-14-oxo-19α-methylmalonyloxy-isopimara-9(11),15-diene (3) in addition to the known compounds isopimaric acid (4), 7oxo-13-epi-pimara-14,15-dien-18oic acid (5), 7oxo-13-epi-pimara-8,15-dien-18oic acid (6), and 6β-hydroxyisopimaric acid (7) were isolated from the hexane extract of Rhizoclonium hieroglyphicum. The structures of compounds 1-7 were established by 1D and 2D NMR techniques. The isolated diterpenoids were screened for antimicrobial activity against gram-positive and gram-negative bacteria and yeast strains.
authors.affiliation: Laboratorio de Investigación de Productos Naturales, Escuela Superior de Ingeniería Química e Industrias Extractivas IPN, Av Instituto Politecnico Nacional S/N, Zacatenco, CP 07708, Mexico DF. rmpg@prodigy.net.mx
authors.forename: Rosa Martha
authors.initials: RM
authors.lastname: Perez Gutierrez
authors.forename: Efren
authors.initials: E
authors.lastname: Garcia Baez
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D041022:Candida tropicalis / Q000187:drug effects; D000460:Chlorophyta / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism
chemical_list: C568246:7beta-hydroxy-14-oxo-19alpha-methylmalonyloxy-isopimara-9(11),15-diene; C568247:7beta-hydroxy-14-oxo-isopimara-8(9),15-dien-19oic acid; C568245:7beta-hydroxy-19alpha-methylmalonyloxy-isopimara-8(14),15-diene; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D004224:Diterpenes