title: Ellagic acid ameliorates lung injury after intestinal ischemia-reperfusion.
abstract: BACKGROUND
  The aim of this study was to investigate the possible protective role of antioxidant treatment with ellagic acid (EA) on lung injury after intestinal ischemia-reperfusion (I/R) injury using biochemical and histopatological approaches.
  
  
  METHODS
  Forty rats were divided into four groups as control, control + EA, I/R, and I/R + EA. The control and control + EA groups were also anesthetized and subjected to laparotomy, but without clamp application. The control + EA and I/R + EA groups were given EA (85 mg/kg) orally prior to experiment. The I/R and I/R + EA groups underwent 30 minutes of intestinal ischemia and 1 hour of reperfusion. In all groups, serum total antioxidant capacity (TAC) and malondialdehyde (MDA) levels were determined. TAC, total oxidative status (TOS), and oxidative stress index (OSI) in lung tissue were measured. Lung tissue histopathology was also evaluated by light microscopy.
  
  
  RESULTS
  TAC levels were higher in control, EA, and I/R + EA groups while TOS, OSI, and MDA levels were lower in these groups compared with I/R group. Serum MDA levels were significantly higher in I/R + EA group than that of control group. Lung tissue TAC levels were lower in I/R + EA group while OSI values were higher in that groups compared with EA group. Histological tissue damage was milder in the EA treatment group than in the I/R group.
  
  
  CONCLUSIONS
  These results suggest that EA treatment protected the rats lung tissue against intestinal I/R injury.
authors.affiliation: Department of General Surgery, Medical School, Dicle University, Diyarbakιr, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Böyük
authors.forename: Akin
authors.initials: A
authors.lastname: Onder
authors.forename: Murat
authors.initials: M
authors.lastname: Kapan
authors.forename: Metehan
authors.initials: M
authors.lastname: Gümüş
authors.forename: Uğur
authors.initials: U
authors.lastname: Fιrat
authors.forename: Mustafa Kemal
authors.initials: MK
authors.lastname: Başaralι
authors.forename: Harun
authors.initials: H
authors.lastname: Alp