title: Overweight children with type 1 diabetes have a more favourable lipid profile than overweight non-diabetic children.
abstract: In the present article, we aimed to compare the cardiometabolic risk between overweight children with and without type 1 diabetes (T1DM). Therefore, data with regard to cardiometabolic risk parameters of 44 overweight Caucasian children (3-18 years) with T1DM were matched with 44 overweight peers without T1DM for sex, ethnicity, age and standard deviation score of BMI (Z-BMI). Detailed history was taken, information regarding anthropometrics and family history were collected and blood pressure was measured. Blood samples were collected for evaluation of lipid profiles (fasting in controls, non-fasting in T1DM children), alanine aminotransferase and HbA1c (in children with T1DM). It was found that overweight children with T1DM had lower median standard deviation score of waist circumference (Z-WC) as compared to the overweight control group [median, 2.0 (interquartile range, IQR, 1.5-2.3) vs. 2.6 (IQR, 2.0-2.9), P < 0.001]. After adjustment for Z-WC, in children with T1DM, median high-density lipoprotein cholesterol levels were significantly higher and median low-density lipoprotein cholesterol lower in T1DM children, as compared to their peers without T1DM [1.40 (IQR, 1.2-1.5) vs. 1.2 (IQR, 1.0-1.3) and 2.7 (IQR, 2.5-3.2) vs. 3.0 (IQR, 2.5-3.4), respectively, all P < 0.01]. When dividing children according to glycaemic status, children with suboptimal glycaemic control had higher values of triglycerides as compared to well-controlled children [1.3 (IQR, 1.0-1.8) vs. 0.96 (IQR, 0.80-1.2), P = 0.036]. In conclusion, overweight children with T1DM have a more favourable lipid profile, as compared to non-diabetic overweight controls, in spite of a higher frequency of a positive family history of CVD, T2DM and hypertension. Still, paediatricians should give extra attention to cardiometabolic risk factors within this vulnerable group, taking into account the already high cardiometabolic risk.
authors.affiliation: Department of Pediatrics, Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands. m.vanvliet@slz.nl
authors.forename: Mariska
authors.initials: M
authors.lastname: van Vliet
authors.forename: Josine C
authors.initials: JC
authors.lastname: van der Heyden
authors.forename: Michaela
authors.initials: M
authors.lastname: Diamant
authors.forename: Inès A
authors.initials: IA
authors.lastname: von Rosenstiel
authors.forename: Roger K
authors.initials: RK
authors.lastname: Schindhelm
authors.forename: Martijn W
authors.initials: MW
authors.lastname: Heymans
authors.forename: Desiderius P M
authors.initials: DP
authors.lastname: Brandjes
authors.forename: Jos H
authors.initials: JH
authors.lastname: Beijnen
authors.forename: Henk J
authors.initials: HJ
authors.lastname: Aanstoot
authors.forename: Henk J
authors.initials: HJ
authors.lastname: Veeze
mesh_terms: D000293:Adolescent; D000410:Alanine Transaminase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000209:etiology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D050177:Overweight / Q000097:blood* / Q000150:complications; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*; D055105:Waist Circumference
chemical_list: D000410:Alanine Transaminase; D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D014280:Triglycerides; C517652:hemoglobin A1c protein, human