title: Preparation and surface properties of polyrotaxane-containing tri-block copolymers as a design for dynamic biomaterials surfaces.
abstract: A tri-block copolymer series containing hydrophilic polyrotaxane and hydrophobic poly(iso-butylmethacrylate) (PiBMA) segments was prepared by atom transfer radical polymerization (ATRP), starting from a pseudopolyrotaxane consisting of 2-bromoisobutyryl end-capped poly(ethylene glycol) (PEG) and α-cyclodextrin (α-CD) and followed by methylation. The dynamic wettability and molecular mobility of the copolymer surfaces were evaluated by dynamic contact angle (DCA) and quartz crystal microbalance with dissipation (QCM-D) measurements, respectively. The polyrotaxane tri-block copolymer surfaces were found to show pronounced dynamic wettability and molecular mobility compared to the control surfaces-a tri-block polymer consisting of PEG and PiBMA, and a PiBMA homopolymer-suggesting that a polyrotaxane loop-like structure exists at the outermost surface in an aqueous environment and exhibits dynamic properties attributable to the possible mobile nature of hydrated α-CD molecules along the PEG backbone. Finally, excellent protein adsorption repellency was achieved on the polyrotaxane tri-block copolymer surface, presumably due to the mobile nature of the supramolecular architecture on the surface.
authors.affiliation: JST-CREST, Chiyoda-ku, Tokyo, Japan.
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Inoue
authors.forename: Lin
authors.initials: L
authors.lastname: Ye
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Ishihara
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Yui
mesh_terms: D001672:Biocompatible Materials; D003505:Cyclodextrins / Q000737:chemistry*; D008745:Methylation; D020442:Poloxamer / Q000737:chemistry*; D043862:Rotaxanes / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D003505:Cyclodextrins; D043862:Rotaxanes; C475673:polyrotaxane; D020442:Poloxamer