title: [Node status in 454 ductal breast cancers cases according to the association with in situ component].
abstract: BACKGROUND
  Studies have shown that breast infiltrating ductal carcinoma develops from precursor lesions or pre-invasive. It is accepted that the risk of invasive ductal carcinoma increased slightly in hyperplasia, but especially in cases of atypical hyperplasia and intraductal carcinoma.
  
  
  OBJECTIVE
  To evaluate and compare the nodal status between ductal breast cancer with in situ component (group 1) or without it (group 2).
  
  
  METHODS
  Descriptive and retrospective study that included 454 ductal breast cancers. Data concerning clinical and pathological variables was collected. All data was compared between both groups.
  
  
  RESULTS
  Among all cases, 176 (38.8%) showed positive lymph nodes, 136 patients (39.5%) from group 1 and 40 cases (36.4%) from group 2. Among group 1 cases, high-grade subgroup showed higher positive lymph node rate (82 cases, 55.4%) than the extensive in situ carcinomas subgroup (84 cases, 49.7%). Both of them had a significant higher rate than group 2 cases (p = 0.003 y p = 0.028, respectively). Moreover, the low-grade in situ carcinomas without cellular necrosi had positive lymph nodes just in 30 cases (24%), significantly lower (p = 0.034) than group 2.
  
  
  CONCLUSIONS
  We did not find overall statistical differences between groups depending on in situ associated component. But when we analyzed in situ subgroups, we found differences with higher positive lymph node rate in high grade carcinomas and extensive in situ carcinomas subgroups, while lower affectation rates were observed in low grade carcinomas (without cellular necrosis), compared to the group of breast cancers without in situ component associated.
authors.affiliation: Departamento de Obstetricia, Ginecologia y Reproducción, Institut Universitari Dexeus, Barcelona, España.
authors.forename: Pau
authors.initials: P
authors.lastname: Carabias-Meseguer
authors.forename: Maite
authors.initials: M
authors.lastname: Cusidó-Gimferrer
authors.forename: Ignacio
authors.initials: I
authors.lastname: Zapardiel-Gutiérrez
authors.forename: Francesc
authors.initials: F
authors.lastname: Tresserra-Casas
authors.forename: Rafael
authors.initials: R
authors.lastname: Fábregas-Xauradó
authors.forename: Jordi
authors.initials: J
authors.lastname: Xercavins-Montoya
mesh_terms: D000328:Adult; D000368:Aged; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000453:epidemiology / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000453:epidemiology / Q000473:pathology / Q000556:secondary*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000145:classification / Q000453:epidemiology / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D008207:Lymphatic Metastasis; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D009336:Necrosis; D009361:Neoplasm Invasiveness / Q000473:pathology; D011230:Precancerous Conditions / Q000453:epidemiology / Q000473:pathology; D012189:Retrospective Studies