title: Kidney abnormalities in sickle cell disease.
abstract: Patients with sickle cell disease exhibits numerous kidney structural and functional abnormalities, changes that are seen along the entire length of the nephron. Changes are most marked in patients with homozygous sickle cell anemia, but are also seen in those with compound heterozygous states and the sickle cell trait. The renal features of sickle cell disease include some of the most common reasons for referral to nephrologists, such as hematuria, proteinuria, tubular disturbances and chronic kidney disease. Therapy of these conditions requires specialized knowledge of their distinct pathogenic mechanisms. Spanish Haemathology and Hemotherapy Association has recently publicated their Clinical Practice Guidelines of SCD management. Renal chapter is reproduced in this article for Nefrología difussion.
authors.affiliation: Nephrology Department, Fundación Alcorcón University Hospital, Madrid, Spain. klopez@fhalcorcon.es
authors.forename: K
authors.initials: K
authors.lastname: López Revuelta
authors.forename: M P
authors.initials: MP
authors.lastname: Ricard Andrés
mesh_terms: D000755:Anemia, Sickle Cell / Q000150:complications*; D018276:Carcinoma, Medullary / Q000209:etiology / Q000473:pathology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D007680:Kidney Neoplasms / Q000209:etiology / Q000473:pathology; D016030:Kidney Transplantation; D008297:Male; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology; D011446:Prospective Studies; D017582:Renal Replacement Therapy; D012805:Sickle Cell Trait / Q000150:complications; D014552:Urinary Tract Infections / Q000150:complications