title: Right ventricle myocardial perfusion scintigraphy: feasibility and expected values in children.
abstract: Stress myocardial perfusion scintigraphy imaging (SMPSI) has important applications for evaluating coronary disease and ventricular function. Studies consistently focus on the left ventricle (LV), with no normal right ventricle (RV) data available. This study sought to evaluate the feasibility of RV perfusion with technetium (Tc-99m) sestamibi using a low radiotracer dose for children free of coronary artery (CA) anomalies and to determine its normal pattern. Patients with a history of Kawasaki disease who showed no coronary complications on selective angiography or no LV perfusion defects on SMPSI were studied at rest and during an exercise challenge. The RV uptake counts were compared with those for different segments of the LV, and multiple ratios of the uptakes between RV and LV segments were calculated. The study subjects were 23 children (age, 11.1 ± 3.3 years) imaged with 0.12 ± 0.03 mCi/kg at rest and 0.31 ± 0.06 mCi/kg during stress. The RV to LV uptake proportion was approximately 6%. Exercise-related uptake increased threefold in both the RV and the LV. The findings showed RV myocardial scintigraphy to be feasible with reproducible ratios. Potential clinical applications include acquired and congenital CA anomalies such as Kawasaki disease, right CA ostium stenosis after a switch operation, and anomalous origin of the right CA.
authors.affiliation: Department of Pediatrics, Université de Montréal, Montreal, QC, H3T 1C5, Canada.
authors.forename: Daniel
authors.initials: D
authors.lastname: Velasco-Sanchez
authors.forename: Raymond
authors.initials: R
authors.lastname: Lambert
authors.forename: Sophie
authors.initials: S
authors.lastname: Turpin
authors.forename: Serge
authors.initials: S
authors.lastname: Laforge
authors.forename: Anne
authors.initials: A
authors.lastname: Fournier
authors.forename: Chantale
authors.initials: C
authors.lastname: Lapierre
authors.forename: Nagib
authors.initials: N
authors.lastname: Dahdah
mesh_terms: D002648:Child; D002675:Child, Preschool; D005080:Exercise Test; D005240:Feasibility Studies; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications / Q000000981:diagnostic imaging*; D055414:Myocardial Perfusion Imaging; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi