title: Optical properties of neonatal skin measured in vivo as a function of age and skin pigmentation.
abstract: Knowledge of the optical properties of neonatal skin is invaluable when developing new, or improving existing optical techniques for use at the neonatal intensive care. In this article, we present in vivo measurements of the absorption μ(a) and reduced scattering coefficient μ(s) (') of neonatal skin between 450 and 600 nm and assess the influence of age and skin pigmentation on the optical properties. The optical properties were measured using a spatially resolved, steady state diffuse reflectance spectroscopy setup, combined with a modified spatially resolved diffusion model. The method was validated on phantoms with known values for the absorption and reduced scattering coefficient. Values of μ(a) and μ(s) (') were obtained from the skin at four different body locations (forehead, sternum, hand, and foot) of 60 neonates with varying gestational age, postnatal age, and skin pigmentation. We found that μ(a) ranged from 0.02 to 1.25 mm(-1) and μ(s) (') was in the range of 1 to 2.8 mm(-1) (5th to 95th percentile of the patient population), independent of body location. In contrast to previous studies, no to very weak correlation was observed between the optical properties and gestational maturity, but a strong dependency of the absorption coefficient on postnatal age was found for dark skinned patients.
authors.affiliation: University of Amsterdam, Biomedical Engineering and Physics, Academic Medical Center, P.O. Box 22700, NL-1100 DE Amsterdam. n.bosschaart@amc.uva.nl
authors.forename: Nienke
authors.initials: N
authors.lastname: Bosschaart
authors.forename: Rosaline
authors.initials: R
authors.lastname: Mentink
authors.forename: Joke H
authors.initials: JH
authors.lastname: Kok
authors.forename: Ton G
authors.initials: TG
authors.lastname: van Leeuwen
authors.forename: Maurice C G
authors.initials: MC
authors.lastname: Aalders
mesh_terms: D000042:Absorption; D000328:Adult; D000367:Age Factors; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D015931:Intensive Care, Neonatal; D008954:Models, Biological; D015999:Multivariate Analysis; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D012867:Skin / Q000737:chemistry*; D012879:Skin Physiological Phenomena; D012880:Skin Pigmentation / Q000502:physiology*; D013057:Spectrum Analysis / Q000379:methods*; D018709:Statistics, Nonparametric; D041623:Tomography, Optical Coherence