title: Evaluation of analgesic, anti-inflammatory and hepatoprotective effects of lycorine from Sternbergia fisheriana (Herbert) Rupr.
abstract: The present study reports the potential antinociceptive, anti-inflammatory and hepatoprotective activities of lycorine from Sternbergia fischeriana (Herbert) Rupr. (Amaryllidaceae). Lycorine was evaluated on mice by using acetic-acid induced writhing and tail-flick tests. Lycorine exhibited stronger inhibition than aspirin in acetic-acid induced abdominal stretching at 1.0mg/kg dose. Lycorine also showed antinociceptive activity at 1.0mg/kg dose in tail-flick test. The anti-inflammatory activity of lycorine was not found to be significant at dose of 0.5mg/kg. However, at doses of 1.0mg/kg and 1.5mg/kg, i.p. showed a significant reduction with 53.45% and 36.42%, respectively in rat paw oedema induced by carrageenan against the reference anti-inflammatory drug indomethacin (3mg/kg, i.p.) (95.70%). The ED(50) of lycorine was determined as 0.514 mg/kg. Hepatoprotective activity of lycorine on carbon tetrachloride (CCl(4)) induced acute liver toxicity following biochemical parameters were also evaluated. Rats were treated with lycorine at doses of 1.0mg/kg and 2.0mg/kg, i.p. Results of biochemical tests were confirmed by histopathological examination. Lycorine exhibited significant hepatoprotective effect at dose of 2.0mg/kg i.p. dose.
authors.affiliation: Ankara University, Faculty of Pharmacy, Department of Pharmacognosy, 06100 Ankara, Turkey. gulcin.saltan@pharmacy.ankara.edu.tr
authors.forename: G Saltan
authors.initials: GS
authors.lastname: Çitoğlu
authors.forename: O Bahadir
authors.initials: OB
authors.lastname: Acikara
authors.forename: B Sever
authors.initials: BS
authors.lastname: Yilmaz
authors.forename: H
authors.initials: H
authors.lastname: Ozbek
mesh_terms: D047151:Amaryllidaceae Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology*; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D019668:Liliaceae / Q000737:chemistry*; D008297:Male; D051379:Mice; D015394:Molecular Structure; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy; D010617:Phenanthridines / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D047151:Amaryllidaceae Alkaloids; D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010617:Phenanthridines; C015330:lycorine