title: [Influence of the high peak serum estradiol on the outcome of in vitro fertilization cycles].
abstract: BACKGROUND
  For the use of assisted reproductive technologies of high complexity (IVF-ET and ICSI) is essential to proper ovarian stimulation with recombinant FSH drugs menotropins, as well as the use of GnRH analogues.
  
  
  OBJECTIVE
  To correlate serum estradiol level on day 10th with the outcome of in vitro fertilization cycles.
  
  
  METHODS
  Retrospective study of 523 IVF cycles, selected and analyzed from 2005 to 2009. Patients underwent individualized stimulation protocols with gonadotropins and agonist (late luteal phase). The patients were divided into three groups according with the serum level of estradiol on day 10th of stimulation: Group I, patients with serum level of Estradiol below 1,000 pg/mL; Group II, with levels between 1,000-4,000 pg/mL; and Group III, with levels above 4,000 pg/mL. Peak serum estradiol levels, oocyte number, fertilization rates, implantation rates, and pregnancy rates were compared among groups.
  
  
  RESULTS
  The fertilization rate was 62.8 in Group I; 60.6% in Group II, and 54.2% in Group III. The pregnancy rate in Group I was 29.8%; in Group II, 37.3%; and 24% for Group III. The implantation rates were 14, 22 and 14% for each group respectively (I, II and III).
  
  
  CONCLUSIONS
  There is an inverse relationship between high peak serum estradiol levels and pregnancy rate; the implantation rate seems affected by the extreme levels of serum estradiol. The percent of total mature oocytes and fertilization rate improve with serum levels of estradiol at physiologic values.
authors.affiliation: Residente de Biología de la Reproducción Humana, Centro de Fertilidad IECH, Monterrey, NL. carmona@iech.com.mx
authors.forename: Israel Obed
authors.initials: IO
authors.lastname: Carmona-Ruiz
authors.forename: Pedro
authors.initials: P
authors.lastname: Galache-Vega
authors.forename: Roberto
authors.initials: R
authors.lastname: Santos-Haliscak
authors.forename: Pablo
authors.initials: P
authors.lastname: Díaz-Spíndola
authors.forename: Víctor Alfonso
authors.initials: VA
authors.lastname: Batiza-Reséndiz
authors.forename: Samuel
authors.initials: S
authors.lastname: Hernández-Ayup
mesh_terms: D000328:Adult; D010064:Embryo Implantation; D004958:Estradiol / Q000097:blood*; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D054315:Oocyte Retrieval; D009865:Oocytes / Q000166:cytology; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D011388:Prolactin / Q000097:blood; D012189:Retrospective Studies
chemical_list: D004958:Estradiol; D011388:Prolactin; D005640:Follicle Stimulating Hormone