title: Synthesis and in vitro study of antiviral and virucidal activity of novel 2-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetamide derivatives.
abstract: 2-[(4-Methyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetamide derivatives were synthesized and their structures were confirmed by 1H NMR, IR, and elemental analysis. Cytotoxicity of the compounds towards HEK-293 and GMK cells was evaluated. Moreover, the antiviral and virucidal activities of these compounds against human adenovirus type 5 and ECHO-9 virus were assessed. Some of the newly synthesized derivatives have the potential to reduce the viral replication of both tested viruses.
authors.affiliation: Department of Organic Chemistry, Medical University, Staszica 6, 20-081 Lublin, Poland. monika.wujec@am.lublin.pl
authors.forename: Monika
authors.initials: M
authors.lastname: Wujec
authors.forename: Tomasz
authors.initials: T
authors.lastname: Plech
authors.forename: Agata
authors.initials: A
authors.lastname: Siwek
authors.forename: Barbara
authors.initials: B
authors.lastname: Rajtar
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Polz-Dacewiczb
mesh_terms: D000081:Acetamides / Q000138:chemical synthesis* / Q000494:pharmacology*; D000256:Adenoviridae / Q000187:drug effects; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002460:Cell Line; D004459:Echovirus 9 / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000081:Acetamides; D000998:Antiviral Agents; D014230:Triazoles