title: Platelet activity indices in patients with deep vein thrombosis.
abstract: BACKGROUND
  Extensive research has been performed regarding the association between platelet activity indices and various cardiovascular disorders. Less clear data, however, are present between these indices and deep vein thrombosis (DVT).
  
  
  OBJECTIVE
  The aim of this study was to investigate the association between platelet activity indices and DVT in a relatively large population.
  
  
  METHODS
  Mean platelet volume (MPV), mean platelet mass (MPM), and mean platelet component (MPC) were measured by an autoanalyzer in a total of 203 patients with DVT and the results were compared with 210 age- and sex-matched controls without DVT.
  
  
  RESULTS
  There were significant differences between the study and control groups in MPV (8.6 ± 1.3 fL vs 7.9 ± 0.5 fL [95% CI -0.82 to -0.44], P < .001, respectively), MPM (2.2 ± 0.3 pg vs 2.0 ± 0.1 pg [95% CI -0.20 to -0.11], P < .001, respectively), and MPC (24.9 ± 3.2 g/dL vs 26.3 ± 1.6 g/dL [95% CI 0.91 to 1.89], P < .001, respectively). These 3 platelet activity indices were also found to be significant predictors of the presence of DVT (all Ps < .001).
  
  
  CONCLUSIONS
  In patients with DVT, the presence of DVT was closely associated with increased platelet activation. The MPV, MPM, and MPC may identify patients requiring aggressive antiplatelet treatment.
authors.affiliation: Department of Radiology, Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey. nurdancay@yahoo.com
authors.forename: Nurdan
authors.initials: N
authors.lastname: Cay
authors.forename: Ali
authors.initials: A
authors.lastname: Ipek
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gumus
authors.forename: Zulfu
authors.initials: Z
authors.lastname: Birkan
authors.forename: Evrim
authors.initials: E
authors.lastname: Ozmen
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D001792:Blood Platelets / Q000502:physiology* / Q000648:ultrastructure; D048429:Cell Size; D015897:Comorbidity; D048909:Diabetes Complications / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation; D010976:Platelet Count; D010979:Platelet Function Tests / Q000295:instrumentation / Q000379:methods; D012907:Smoking / Q000097:blood; D013924:Thrombophlebitis / Q000097:blood* / Q000000981:diagnostic imaging; D018616:Ultrasonography, Doppler, Duplex
chemical_list: D001786:Blood Glucose; D008055:Lipids