title: Synthesis, characterization and biological activity of some 1, 3, 4-thiadiazol derivatives.
abstract: Thiadiazoles are their derivatives exhibit a wide variety of pharmacological activities such as Antibacterial and anti-inflammatory. In the present study we have synthesized derivatives some 2,5 substituted 1,3,4- thiadiazoles. The structures of these synthesized compounds were confirmed by IR, NMR, and MASS spectra data. These compounds were evaluated for varies biological activities such as antibacterial and anti-inflammatory activity.
authors.affiliation: Kamla Nehru Institute of Management and Technology, Sultanpur UP, India. adi_arv26@rediffmail.com
authors.forename: Arvind Kumar
authors.initials: AK
authors.lastname: Singh
authors.forename: Mahfooz
authors.initials: M
authors.lastname: Lohani
authors.forename: Umesh Pratap
authors.initials: UP
authors.lastname: Singh
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D001234:Aspergillus niger / Q000187:drug effects; D001549:Benzamides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D002351:Carrageenan / Q000494:pharmacology; D004487:Edema / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D007249:Inflammation / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D051381:Rats; D011919:Rats, Inbred Strains; D013055:Spectrophotometry, Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001549:Benzamides; D013830:Thiadiazoles; D002351:Carrageenan