title: Influence of Cu supplementation on toxic and essential trace element status in intensive reared beef cattle.
abstract: The aim of this study is to evaluate if dietary Cu supplementation that leads to a hepatic Cu accumulation over the normal range has an influence on trace element status that could contribute to the pathogenesis of other mineral related disorders. Samples (liver, kidney, spleen, diaphragm and brain) of beef calves receiving typical commercial diets Cu supplemented and non-supplemented were tested for differences in non-essential and essential trace elements determined by ICP-MS. As (kidney and diaphragm), Hg (liver and kidney), and Pb (liver, kidney and spleen) were significantly lower, while Cd residues (liver and kidney) were significantly higher in the Cu supplemented group. Mn and Ni significantly decreased and Mo increased in the brain, and Se (diaphragm) decreased in the Cu supplemented group. These interactions are unknown, and possibly with more than two metals involved as suggested in the case of the ratio Se:Cu in the animals of this study. The possible role of Cu supplementation on the status of certain metals associated to neurological diseases (Mn-Ni) in the brain deserves further investigation. Finally new research on Cu-Se supplementation is necessary to better understand the risk of the animals to suffer from Se deficiency.
authors.affiliation: Universidade de Santiago de Compostela, Departamento de Patoloxía Animal, Facultade de Veterinaria, 27002 Lugo, Spain. garcia.vaquero@usc.es
authors.forename: M
authors.initials: M
authors.lastname: García-Vaquero
authors.forename: M
authors.initials: M
authors.lastname: López-Alonso
authors.forename: J L
authors.initials: JL
authors.lastname: Benedito
authors.forename: J
authors.initials: J
authors.lastname: Hernández
authors.forename: B
authors.initials: B
authors.lastname: Gutiérrez
authors.forename: M
authors.initials: M
authors.lastname: Miranda
mesh_terms: D000818:Animals; D001151:Arsenic / Q000032:analysis / Q000633:toxicity*; D001921:Brain / Q000378:metabolism; D002417:Cattle / Q000378:metabolism*; D003300:Copper / Q000008:administration & dosage* / Q000493:pharmacokinetics; D003964:Diaphragm; D004032:Diet / Q000662:veterinary; D019587:Dietary Supplements; D007668:Kidney / Q000378:metabolism; D007854:Lead / Q000032:analysis / Q000633:toxicity*; D008099:Liver / Q000378:metabolism; D008460:Meat; D008628:Mercury / Q000032:analysis / Q000633:toxicity*; D012643:Selenium / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics; D013154:Spleen / Q000378:metabolism
chemical_list: D007854:Lead; D003300:Copper; D008628:Mercury; D012643:Selenium; D001151:Arsenic