title: Gel from unripe Musa sapientum peel to repair surgical wounds in rats.
abstract: OBJECTIVE
  To determine the optimum concentration of a gel obtained from unripe banana (Musa sapientum) peel for wound treatment in rats.
  
  
  METHODS
  A randomized triple blind study was conducted with 40 Wistar rats, which were divided into 4 groups: CG, control group; G2%, 2% gel concentration group; G4%, 4% gel concentration group; and G10%, 10 % gel concentration group. The banana peel gel was applied daily, for 7 days, to a 4-cm(2) wound created on the back of each animal of all groups. After this period, the wounds were biopsied. Statistical analysis was carried out using the Kruskal-Wallis test complemented by the Student-Newman-Keuls test.
  
  
  RESULTS
  Macroscopic examination revealed that partial epithelialization occurred in all groups. Wound contraction was also observed in all groups and ranged from 1.38 to 1.57 mm in the study groups, and from 1.03 to 1.10 mm in the control group, with significant differences (p < 0.05) between the groups: CG and G10%, G2% and G4%, G2% and G10%. The interquartile deviation was smaller between the groups CG and G4%.
  
  
  CONCLUSIONS
  The 4% gel obtained from unripe banana peel (G4%) resulted in better epithelialization of wounds healed by secondary intention compared with other gel concentrations.
authors.affiliation: UNIFESP, Sao Paulo, Brazil.
authors.forename: Dênia Amélia Novato Castelli Von
authors.initials: DA
authors.lastname: Atzingen
authors.forename: Alfredo
authors.initials: A
authors.lastname: Gragnani
authors.forename: Daniela Francescato
authors.initials: DF
authors.lastname: Veiga
authors.forename: Luis Eduardo Felipe
authors.initials: LE
authors.lastname: Abla
authors.forename: Adriana Rodrigues dos Anjos
authors.initials: AR
authors.lastname: Mendonça
authors.forename: Clayton Aparecido de
authors.initials: CA
authors.lastname: Paula
authors.forename: Yara
authors.initials: Y
authors.lastname: Juliano
authors.forename: José Carlos
authors.initials: JC
authors.lastname: Correa
authors.forename: Marcio Raimundo de
authors.initials: MR
authors.lastname: Faria
authors.forename: Lydia Masako
authors.initials: LM
authors.lastname: Ferreira
mesh_terms: D000818:Animals; D001706:Biopsy; D004305:Dose-Response Relationship, Drug; D005782:Gels / Q000008:administration & dosage; D028521:Musa; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000008:administration & dosage*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000188:drug therapy*
chemical_list: D005782:Gels; D010936:Plant Extracts