title: Identification of the distinctive type i/XhoI+ strain of Epstein-Barr virus in gastric carcinoma in Peru.
abstract: OBJECTIVE
  To clarify the reason for the low frequency of Epstein-Barr virus-associated gastric carcinoma (EBVaGC) in Peru, despite the high frequency reported in neighboring countries, the distribution of the distinctive EBV (type i/XhoI+) strain in EBVaGC and a healthy population was examined.
  
  
  METHODS
  EBV polymorphisms in BamHI W1/I1 and XhoI restriction site of the latent membrane protein 1 gene (LMP1) were examined among 11 EBVaGCs and 172 healthy controls from Peru, and these frequencies were compared with those in a previous study of Chile and Colombia (n=303).
  
  
  RESULTS
  The frequency of the distinctive EBV strain in EBVaGCs (55%) was significantly higher than that in controls (7%). Furthermore, the frequency of this EBV type in Peruvian controls was significantly lower than that in controls from Chile and Colombia (27%, p<0.001).
  
  
  CONCLUSIONS
  The low frequency of the distinctive EBV strain among the Peruvian population might be a reason for the lower incidence of EBVaGC in Peru, as compared with neighboring countries.
authors.affiliation: Department of Epidemiology and Preventive Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka 8-35-1, Kagoshima 890-8544, Japan.
authors.forename: Paula
authors.initials: P
authors.lastname: Ordonez
authors.forename: Chihaya
authors.initials: C
authors.lastname: Koriyama
authors.forename: Shan
authors.initials: S
authors.lastname: Ding
authors.forename: Elena
authors.initials: E
authors.lastname: Yoshiwara
authors.forename: Alejandro H
authors.initials: AH
authors.lastname: Corvalan
authors.forename: Juan
authors.initials: J
authors.lastname: Takano
authors.forename: Jesus L
authors.initials: JL
authors.lastname: Chirinos
authors.forename: Jose
authors.initials: J
authors.lastname: Watanabe
authors.forename: Juan
authors.initials: J
authors.lastname: Miyagui
authors.forename: Heriberto
authors.initials: H
authors.lastname: Hidalgo
authors.forename: Pedro
authors.initials: P
authors.lastname: Chacon
authors.forename: Victor
authors.initials: V
authors.lastname: Linares
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Eizuru
authors.forename: Suminori
authors.initials: S
authors.lastname: Akiba
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002677:Chile; D003105:Colombia; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism*; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010568:Peru; D013274:Stomach Neoplasms / Q000821:virology*; D055815:Young Adult
chemical_list: C034510:CTCGAG-specific type II deoxyribonucleases; D015252:Deoxyribonucleases, Type II Site-Specific