title: Clinicopathological study of poorly differentiated colorectal adenocarcinomas: comparison between solid-type and non-solid-type adenocarcinomas.
abstract: OBJECTIVE
  We aimed to clarify the clinicopathological features of poorly differentiated colorectal adenocarcinomas and to define two subtypes of these adenocarcinomas.
  
  
  METHODS
  We enrolled 78 patients, who had undergone surgery for poorly differentiated colorectal adenocarcinoma. On the basis of the microscopy results, the Por1 type is characterized by cancer cells with solid growth and little stroma; most cells contained round-shaped nuclei. The Por2 type is characterized by cancer cells with a predominantly trabecular structure; these tumors are rich in fibrous stroma. The two groups were compared for clinicopathological factors.
  
  
  RESULTS
  The frequency of metastasis of the lymph node, liver, lung, and peritoneum in the Por2 group was significantly higher than that in the Por1 group. The survival rate in the Por2 group was lower than that in the Por1 group.
  
  
  CONCLUSIONS
  The classification system described in this study is a simple and easy method for predicting poorly differentiated colorectal adenocarcinomas, and the prognosis of patients with Por2 tended to be unfavorable than that of Por1.
authors.affiliation: Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, 1-1, Kanokoden, Chikusa Nagoya, Aichi 464-8681, Japan. kkomori@aichi-cc.jp
authors.forename: Koji
authors.initials: K
authors.lastname: Komori
authors.forename: Yukihide
authors.initials: Y
authors.lastname: Kanemitsu
authors.forename: Seiji
authors.initials: S
authors.lastname: Ishiguro
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Sano
authors.forename: Seiji
authors.initials: S
authors.lastname: Ito
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Abe
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Senda
authors.forename: Kazunari
authors.initials: K
authors.lastname: Misawa
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ito
authors.forename: Norihisa
authors.initials: N
authors.lastname: Uemura
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kato
mesh_terms: D000230:Adenocarcinoma / Q000145:classification* / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D002454:Cell Differentiation; D015179:Colorectal Neoplasms / Q000145:classification* / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D015996:Survival Rate