title: Spontaneous occurrence of dissecting aneurysms in the region of the ductus arteriosus in four-day-old Wistar rat pups.
abstract: Dissecting aortic aneurysms, generally involving the thoracic aorta, have been shown to be caused by specific aliphatic amines in developing rats. Whether such lesions might occur spontaneously in control rats is not known. Therefore, in this study, 1,016 four-day-old, untreated rats culled from ongoing scheduled breeding studies were subjected to gross and histopathological examination in order to create a background control data base on the incidence of spontaneous aortic dissecting aneurysms. Two animals (0.2%) were found to have small dissecting aortic aneurysms, and an additional 2 (0.2%) had only hemorrhagic lesions. All of these lesions were limited to the region of the ductus arteriosus. An additional 18 findings were judged to be artifacts. These findings suggest that small vascular dissections may rarely occur in the aortic arch adjacent to the ductus arteriosus. Special attention should be paid in experimental studies to avoid confusing these small spontaneous lesions with treatment-induced lesions or artifacts.
authors.affiliation: Product Safety, BASF SE, 67056 Ludwigshafen, Germany. silke.treumann@basf.com
authors.forename: Silke
authors.initials: S
authors.lastname: Treumann
authors.forename: Steffen
authors.initials: S
authors.lastname: Schneider
authors.forename: Sibylle
authors.initials: S
authors.lastname: Gröters
authors.forename: Nigel P
authors.initials: NP
authors.lastname: Moore
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Boor
mesh_terms: D000784:Aortic Dissection / Q000175:diagnosis* / Q000473:pathology*; D000818:Animals; D001013:Aorta, Thoracic / Q000002:abnormalities* / Q000473:pathology; D001014:Aortic Aneurysm / Q000175:diagnosis* / Q000473:pathology*; D016477:Artifacts; D004373:Ductus Arteriosus / Q000002:abnormalities* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar