title: Lipoprotein-associated phospholipase A2 activity in patients with preserved left ventricular ejection fraction.
abstract: BACKGROUND
  A significant proportion of heart failure (HF) patients have preserved ejection fraction (EF). Considering that inflammation and oxidative stress are involved in HF evolution, we investigated lipoprotein-associated phospholipase A2 (LpPLA2), an enzyme involved in these pathophysiologic processes in relation to EF.
  
  
  RESULTS
  The study included 208 HF patients and 20 healthy controls. HF patients with preserved EF (HFpEF) represented 42.31% of all HF patients. LpPLA2 activity was significantly increased in HF patients when compared with controls and was higher in HFpEF than in HF with reduced EF patients (HFrEF). The incidence of left ventricular hypertrophy was higher in HFpEF than in HFrEF (EF < 50).
  
  
  CONCLUSIONS
  Confirming its role as a marker of vascular inflammation, LpPLA2 seems to be a biomarker constantly correlated with HF, regardless of etiology. Elevated plasma values of LpPLA2 in HFpEF are consistent with the exacerbated inflammatory status.
authors.affiliation: "Victor Babes" National Institute of Pathology , Bucharest , Romania. Emoldoveanu@hotmail.com
authors.forename: Elena
authors.initials: E
authors.lastname: Moldoveanu
authors.forename: Mihnea
authors.initials: M
authors.lastname: Serban
authors.forename: Daciana S
authors.initials: DS
authors.lastname: Marta
authors.forename: Irina
authors.initials: I
authors.lastname: Serban
authors.forename: Radu
authors.initials: R
authors.lastname: Huica
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000097:blood / Q000378:metabolism*; D000368:Aged; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D004562:Electrocardiography; D005260:Female; D006333:Heart Failure / Q000201:enzymology* / Q000503:physiopathology*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000201:enzymology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013318:Stroke Volume
chemical_list: D015415:Biomarkers; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase