title: Type 2 diabetic patients with non-alcoholic fatty liver disease exhibit significant haemorheological abnormalities.
abstract: Haemorheological abnormalities have been described in diabetes mellitus, as well as in non-alcoholic fatty liver disease (NAFLD). However, the relationship between the changes in liver fat content and haemorheology is unknown. The current study aims to show the correlation between haemorheological parameters and intrahepatic lipid content (IHLC) in patients with type 2 diabetes. The serum biochemical markers, such as fasting plasma glucose (FPG), haemoglobin A1c (HbA1c), liver enzymes, lipid profiles, and haemorheological properties, were examined. IHLC was quantified using proton magnetic resonance spectroscopy ((1)H-MRS) scanning of the liver. A significant correlation was observed between IHLC and whole blood viscosity at high, middle, and low shear rates. IHLC also positively correlated with haematocrit, the reduced whole blood viscosity at low and middle shear rates, and the erythrocyte aggregation index. Diabetic patients with NAFLD exhibited significant haemorheological abnormalities compared with patients without NAFLD. In summary, haemorheological disorders are linked to non-alcoholic fatty liver in type 2 diabetes.
authors.affiliation: Institute of Integrative Traditional and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Dong
authors.forename: Fu'er
authors.initials: F
authors.lastname: Lu
authors.forename: Nan
authors.initials: N
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Zou
authors.forename: Jingjing
authors.initials: J
authors.lastname: Rao
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002681:China; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology / Q000473:pathology; D005234:Fatty Liver / Q000097:blood* / Q000453:epidemiology / Q000473:pathology; D005260:Female; D018056:Hemorheology / Q000502:physiology; D006801:Humans; D008055:Lipids / Q000097:blood; D008099:Liver / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease
chemical_list: D015415:Biomarkers; D008055:Lipids