title: Involvement of SEPT4_i1 in hepatocellular carcinoma: SEPT4_i1 regulates susceptibility to apoptosis in hepatocellular carcinoma cells.
abstract: SEPT4 belongs to the Septin family with multiple functions in cell division, cytoskeletal organization and other processes. This study aims to investigate the relationship between SEPT4_i1 isoform and human hepatocellular carcinoma (HCC). We showed that over-expression of SEPT4_i1 in HCC cells was able to sensitize cells to serum starvation-induced apoptosis. By contrast, knockdown of SEPT4_i1 expression in HCC cells was able to rescue cells from apoptosis induced by serum deprivation and to promote cell growth. Expressional analysis of SEPT4_i1 in tumor tissues further revealed that SEPT4_i1 was significantly down-regulated in human HCC tissues. Taken together, these data suggests a tumor suppressor role of SEPT4_i1 in HCC through regulating HCC cell apoptosis.
authors.affiliation: State Key Laboratory of Genetic Engineering, Institute of Genetics, Fudan University, 220 Handan Road, Shanghai, 200433, People's Republic of China.
authors.forename: Suqin
authors.initials: S
authors.lastname: Shen
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Wu
authors.forename: Hexige
authors.initials: H
authors.lastname: Saiyin
authors.forename: Guoyuan
authors.initials: G
authors.lastname: Liu
authors.forename: Long
authors.initials: L
authors.lastname: Yu
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D016895:Culture Media, Serum-Free / Q000494:pharmacology; D019610:Cytoprotection / Q000187:drug effects; D015536:Down-Regulation / Q000187:drug effects; D055785:Gene Knockdown Techniques; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology*; D020033:Protein Isoforms / Q000378:metabolism; D058112:Septins / Q000378:metabolism*; D014410:Tumor Stem Cell Assay
chemical_list: D016895:Culture Media, Serum-Free; D020033:Protein Isoforms; C492027:SEPTIN4 protein, human; D058112:Septins