title: Synthesis, characterization, and light-controlled antibiotic application of a composite material derived from polyurethane and silica xerogel with embedded photoactive manganese nitrosyl.
abstract: The synthesis of a light-sensitive polyurethane-based composite material (PUX-NO) is described. In its polyurethane medium, PUX-NO contains entrapped silica xerogel particles in which a photoactive manganese nitrosyl has been incorporated. Green flexible films of PUX-NO readily release nitric oxide (NO) only when exposed to low power (mW) visible light. Incorporation of the nitrosyl in the xerogel not only retains the nitrosyl (NO donor) within the composite material but also provides the right extent of hydration. Pre-swelled films of PUX-NO have water content close to 30 Wt % and such films can be stored for months under slightly moist condition without loss in NO-delivering capacity. The NO-releasing parameters of the film have been determined. The NO-releasing capacity of PUX-NO films can be conveniently altered by changing the amount of the nitrosyl as well as the thickness of the films. Patches of PUX-NO film have been successfully employed to reduce drastically bacterial loads of both gram-positive and gram-negative bacteria including methicillin-resistant Staphylococcus aureus and Acinetobacter baumannii under the total control of light. Effective control of infections by these bacterial pathogens via delivery of proper doses of NO only to the sites of infection appears feasible with PUX-NO films.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA.
authors.forename: Brandon J
authors.initials: BJ
authors.lastname: Heilman
authors.forename: Genevieve M
authors.initials: GM
authors.lastname: Halpenny
authors.forename: Pradip K
authors.initials: PK
authors.lastname: Mascharak
mesh_terms: D040981:Acinetobacter baumannii / Q000378:metabolism; D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry; D005782:Gels / Q000737:chemistry*; D006801:Humans; D008027:Light; D008345:Manganese / Q000737:chemistry*; D008422:Materials Testing; D055624:Methicillin-Resistant Staphylococcus aureus / Q000378:metabolism; D009569:Nitric Oxide / Q000737:chemistry; D009584:Nitrogen / Q000737:chemistry*; D011140:Polyurethanes / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D013207:Staphylococcal Skin Infections / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D005782:Gels; D011140:Polyurethanes; D009569:Nitric Oxide; D008345:Manganese; D012822:Silicon Dioxide; D009584:Nitrogen