title: A hypertriglyceridemic state increases high sensitivity C-reactive protein of Japanese men with normal glucose tolerance.
abstract: Both fasting and postprandial hypertriglyceridemia have been identified as risk markers for cardiovascular disease. High-sensitivity C-reactive protein (hs-CRP), known to independently predict future cardiovascular disease, has also been reported to be a direct participant in the progression of atherosclerosis. We evaluated whether or not fasting and/or postprandial hypertriglyceridemia influence hs-CRP of men with normal glucose tolerance. According to the triglyceride (TG) level, measured before and 1 and 2 h after a meal tolerance test, subjects were classified into a normotriglyceridemic (NTG) group (n = 86), a postprandial hypertriglyceridemia (PHTG) group (n = 50), or a fasting hypertriglyceridemia (FHTG) group (n = 53). Hs-CRP and HOMA-R were significantly higher in the FHTG group than in the other groups (P < 0.01). The PHTG group had higher hs-CRP than the NTG group (P < 0.05). No significant differences in age, BMI, LDL cholesterol, or carotid intima-media thickness were found in comparison of the three groups. Multivariate linear regression analysis showed that the area under the TG curve (AUC-TG), HbA1c, and BMI were independently correlated with hs-CRP (P < 0.001, P = 0.016, P = 0.032, respectively). Our data suggests that a hypertriglyceridemic state is associated with hs-CRP irrespective of BMI, LDL-C, and HDL-C, indicating that hs-CRP might represent chronic inflammation induced by hypertriglyceridemia in Japanese men with normal glucose tolerance.
authors.affiliation: Department of General Internal Medicine, Kyushu University Hospital, Higashi-ku, Fukuoka, 812-8582, Japan. okyouko@gim.med.kyushu-u.ac.jp
authors.forename: Kyoko
authors.initials: K
authors.lastname: Okada
authors.forename: Norihiro
authors.initials: N
authors.lastname: Furusyo
authors.forename: Masayuki
authors.initials: M
authors.lastname: Murata
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Sawayama
authors.forename: Mosaburo
authors.initials: M
authors.lastname: Kainuma
authors.forename: Jun
authors.initials: J
authors.lastname: Hayashi
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000208:ethnology*; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D059168:Carotid Intima-Media Thickness; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D005215:Fasting / Q000502:physiology; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood* / Q000208:ethnology* / Q000503:physiopathology; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period / Q000502:physiology; D012189:Retrospective Studies
chemical_list: D002097:C-Reactive Protein; D002784:Cholesterol; D005947:Glucose