title: Exercise prior to a freely requested meal modifies pre and postprandial glucose profile, substrate oxidation and sympathovagal balance.
abstract: BACKGROUND
  The effects of exercise on glucose and metabolic events preceding and following a freely initiated meal have never been assessed. Moreover, the relationship between these events and sympathovagal balance is not known. The objective of this study was to determine whether exercise prior to a freely requested meal modifies the pre- and postprandial glucose profile, substrate oxidation and sympathovagal balance.
  
  
  METHODS
  Nine young active male subjects consumed a standard breakfast (2298 ± 357 kJ). After 120 min, they either performed 75 min of exercise on a cycle ergometer (EX - 70% VO2max) or rested (RT). Lunch was freely requested but eaten ad libitum only during the 1st session, and then energy intake was fixed across conditions. Glucose and sympathovagal balance were assessed continuously using a subcutaneous glucose monitoring system and analysis of heart rate variability, respectively. Every 5 min, a mean value was calculated for both glucose and sympathovagal balance. Substrate oxidation was determined by calculating the gas exchange ratio when lunch was requested and 180 min after the onset of eating.
  
  
  RESULTS
  Preprandial glucose profiles were found in 72% of the sessions and with a similar frequency under both conditions. Meals were requested after a similar delay (40 ± 12 and 54 ± 10 min in EX and RT respectively; ns). At meal request, sympathovagal balance was not different between conditions but CHO oxidation was lower and fat oxidation higher in EX than in RT (-46% and +63%, respectively; both p < 0.05). Glucose responses to the meal were higher in incremental (+ 48%) but not in absolute value in EX than in RT, with a higher fat oxidation (+ 46%, p < 0.05), and a greater vagal withdrawal (+ 15%, p < 0.05).
  
  
  CONCLUSIONS
  These results show that exercise does not impair preprandial glucose declines at the following meal freely requested, but leads to an increased postprandial glucose response and an elevated fat oxidation, an effect that vagal withdrawal may contribute to explain.
authors.affiliation: Université Paris 13, Laboratoire des Réponses Cellulaires et Fonctionnelles à l'Hypoxie, UFR SMBH, 74 rue Marcel Cachin, 93017, Bobigny, France. dchapelot@gmail.com.
authors.forename: Keyne
authors.initials: K
authors.lastname: Charlot
authors.forename: Aurélien
authors.initials: A
authors.lastname: Pichon
authors.forename: Didier
authors.initials: D
authors.lastname: Chapelot