title: Molecular mechanisms of Barrett's esophagus and adenocarcinoma.
abstract: The following on molecular mechanisms of Barrett's esophagus and adenocarcinoma contains commentaries on the mechanism of bile and gastric acid induced damage; the roles of BMP-4 and CDX-2 in the development of intestinal metaplasia; the transcription factors driving intestinalization in Barrett's esophagus; the contribution of bone marrow to metaplasia and adenocarcinoma; activation and inactivation of transcription factors; and a novel study design targeting molecular pathways in Barrett's esophagus.
authors.affiliation: Department of Cell Biology and Anatomy, College of Medicine, Tucson, Arizona, USA.
authors.forename: Katerina
authors.initials: K
authors.lastname: Dvorak
authors.forename: Aaron
authors.initials: A
authors.lastname: Goldman
authors.forename: Jianping
authors.initials: J
authors.lastname: Kong
authors.forename: John P
authors.initials: JP
authors.lastname: Lynch
authors.forename: Lloyd
authors.initials: L
authors.lastname: Hutchinson
authors.forename: Jean Marie
authors.initials: JM
authors.lastname: Houghton
authors.forename: Hao
authors.initials: H
authors.lastname: Chen
authors.forename: Xiaoxin
authors.initials: X
authors.lastname: Chen
authors.forename: Kausilia K
authors.initials: KK
authors.lastname: Krishnadath
authors.forename: Wytske M
authors.initials: WM
authors.lastname: Westra
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000503:physiopathology; D001471:Barrett Esophagus / Q000235:genetics* / Q000503:physiopathology; D001647:Bile Acids and Salts / Q000502:physiology; D055415:Bone Morphogenetic Protein 4 / Q000502:physiology; D000071616:CDX2 Transcription Factor; D004249:DNA Damage; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000503:physiopathology; D018398:Homeodomain Proteins / Q000502:physiology; D006801:Humans; D015534:Trans-Activators / Q000502:physiology
chemical_list: D001647:Bile Acids and Salts; D055415:Bone Morphogenetic Protein 4; D000071616:CDX2 Transcription Factor; D018398:Homeodomain Proteins; D015534:Trans-Activators