title: [Protective effect of limited fluid resuscitation against intestinal ischemia-reperfusion injury in postpartum rabbits with uncontrolled hemorrhagic shock].
abstract: OBJECTIVE
  To investigate the protective effect of limited fluid resuscitation against intestinal ischemia- reperfusion injury in postpartum rabbits with severe uncontrolled obstetrical hemorrhagic shock.
  
  
  METHODS
  Twenty- four postpartum rabbits were randomly assigned into sham shock group (group P), shock group without interventions (group P0), conventional fluid resuscitation group (group PNL), and limited fluid resuscitation group (group PLH), and the model of severe uncontrolled hemorrhagic shock was established in the latter 3 groups. The rabbits were sacrificed 4 h later, and SOD activity and MDA content in the intestinal mucosa and the degree of injury to the intestinal mucosa were observed.
  
  
  RESULTS
  Ischemia-reperfusion injury of the intestine due to uncontrolled hemorrhagic shock resulted in decreased SOD activity and increased MDA content. The MDA content was significantly lower and SOD activity was significantly higher in group PLH than in group PNL (P<0.05), and the intestinal mucosal tissue morphology and intestinal mucosa barrier lesion increased in group PLH.
  
  
  CONCLUSIONS
  Initial limited fluid  resuscitation can relieve intestinal ischemia-reperfusion injury in postpartum rabbits with severe uncontrolled obstetrical hemorrhagic shock.
authors.affiliation: Department of Gynecolocy and Obstetrics, Southern Medical University, Guangzhou, China. Lphuang2006@126.com
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Huang
authors.forename: Yan-hong
authors.initials: YH
authors.lastname: Yu
authors.forename: Chao
authors.initials: C
authors.lastname: Sheng
authors.forename: Shi-peng
authors.initials: SP
authors.lastname: Gong
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005440:Fluid Therapy / Q000379:methods*; D007422:Intestines / Q000098:blood supply*; D011247:Pregnancy; D011817:Rabbits; D015427:Reperfusion Injury / Q000209:etiology / Q000517:prevention & control*; D012771:Shock, Hemorrhagic / Q000150:complications