title: Natural sulforaphane as a functional chemopreventive agent: including a review of isolation, purification and analysis methods.
abstract: Epidemiological data show that a diet rich in fruits and vegetables can reduce the risk from a number of cancers and chronic diseases. Sulforaphane (SF), a phytochemical constituent of cruciferous vegetables, has been widely researched in recent decades as a potential chemopreventive compound. Nonexistent in intact vegetables, natural SF, is formed from glucoraphanin hydrolyzed by myrosinase. This review summarizes and compares different analysis, isolation and purification methods engaged in SF research. Major important chemopreventive properties of SF investigated in existing research are reviewed and discussed, including antioxidant, anticarcinogenic and anti-inflammatory functions. Considering the potential applications of SF in the future, metabolism, stability and formulation developments of SF are also discussed. Research opportunities are identified based on the review of existing studies to facilitate future explorations on SF, a promising natural compound in chemopreventive therapy.
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, People's Republic of China.
authors.forename: Hao
authors.initials: H
authors.lastname: Liang
authors.forename: Qipeng
authors.initials: Q
authors.lastname: Yuan
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D001709:Biotechnology / Q000379:methods; D002478:Cells, Cultured; D005961:Glucosinolates / Q000378:metabolism; D006801:Humans; D007096:Imidoesters / Q000378:metabolism; D017879:Isothiocyanates; D010091:Oximes; D013454:Sulfoxides; D013861:Thiocyanates / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D016588:Anticarcinogenic Agents; D000975:Antioxidants; D005961:Glucosinolates; D007096:Imidoesters; D017879:Isothiocyanates; D010091:Oximes; D013454:Sulfoxides; D013861:Thiocyanates; C016766:sulforaphane; C119494:glucoraphanin