title: Overview of microarrays in drug discovery and development.
abstract: With the sequencing of the human genome, new tools and technologies have been developed to identify and quantify global gene-expression changes occurring in the cell. One of the main tools being utilized is microarray technology, which allows one to quantitate expression changes of thousands of genes in a single experiment. Microarrays allow researchers to gain an unprecedented understanding of the function and regulation of genes, and are transforming virtually all areas of biological research. In the drug-discovery process, microarrays have the potential to play a role in all stages, from new target discovery through compound profiling and safety assessment. This overview highlights some of these studies and discusses how this technology is transforming the field of drug discovery and development.
authors.affiliation: Abbott Laboratories, Abbott Park, Illinois, USA.
authors.forename: Jeffrey F
authors.initials: JF
authors.lastname: Waring
mesh_terms: D002986:Clinical Trials as Topic; D055808:Drug Discovery; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D010597:Pharmacogenetics; D012107:Research Design