title: Type A monoamine oxidase regulates life and death of neurons in neurodegeneration and neuroprotection.
abstract: In Parkinson's disease, type B monoamine oxidase (MAO-B) is proposed to play an important role in the pathogenesis through production of reactive oxygen species and neurotoxins from protoxicants, such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. In addition, inhibitors of MAO-B protect neurons in the cellular and animal models of Parkinson's and Alzheimer's diseases. However, the role of type A MAO (MAO-A) in neuronal death and neuroprotection by MAO-B inhibitors has been scarcely elucidated. This chapter presents our recent results on the involvement of MAO-A in the activation of mitochondrial death signal pathway and in the induction of prosurvival genes to prevent cell death with MAO-B inhibitors. The roles of MAO-A in the regulation of neuronal survival and death are discussed in concern to find a novel strategy to protect neurons in age-associated neurodegenerative disorders and depression.
authors.affiliation: Department of Neurosciences, Gifu International Institute of Biotechnology, Kakamigahara, Gifu, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Naoi
authors.forename: Wakako
authors.initials: W
authors.lastname: Maruyama
authors.forename: Keiko
authors.initials: K
authors.lastname: Inaba-Hasegawa
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Akao
mesh_terms: D000818:Animals; D016923:Cell Death / Q000187:drug effects / Q000502:physiology; D002470:Cell Survival / Q000502:physiology*; D006801:Humans; D008995:Monoamine Oxidase / Q000378:metabolism / Q000502:physiology* / Q000627:therapeutic use*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology*; D018696:Neuroprotective Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology* / Q000627:therapeutic use*
chemical_list: D008996:Monoamine Oxidase Inhibitors; D018696:Neuroprotective Agents; D008995:Monoamine Oxidase