title: Is there any association between GLY82 ser polymorphism of rage gene and Turkish diabetic and non diabetic patients with coronary artery disease?
abstract: This study was carried out in 52 non-diabetic, 62 diabetic patients with coronary artery disease (CAD) and 55 controls. A Gly to Ser change RAGE gene was analyzed by PCR-RFLP techniques. GlyGly genotype frequency is higher in non-diabetics versus controls (P < 0.001). GlySer frequency is higher in diabetics than controls and non-diabetics (P < 0.001). Ser allele frequency is respectively increased in the order of diabetics > Controls > non-diabetics. These results reveals none association between Gly82Ser and the development of disease in non-diabetic patients. In diabetics with Ser allele, higher prevalence of left-ventricule-hypertrophy was observed, but the significant difference between Gly82Ser and left-ventricule-hypertrophy only found in the whole patient group. As a result Ser allele has much more importance in the development of left-ventricule-hypertrophy than other cardiovascular risk factors. In this study we found the presence of Gly allele contributes to the CAD in non-diabetics and Ser allele may contribute to disease in diabetics.
authors.affiliation: Department of Molecular Medicine, The Institute of Experimental Medicine, Istanbul University, Vakif Gureba Street, Capa-Istanbul, Turkey. ozlemkh@istanbul.edu.tr
authors.forename: Ozlem
authors.initials: O
authors.lastname: Kucukhuseyin
authors.forename: Hulya
authors.initials: H
authors.lastname: Yilmaz-Aydogan
authors.forename: C Selim
authors.initials: CS
authors.lastname: Isbir
authors.forename: Turgay
authors.initials: T
authors.lastname: Isbir
mesh_terms: D003324:Coronary Artery Disease / Q000150:complications* / Q000235:genetics*; D003710:Demography; D048909:Diabetes Complications / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005998:Glycine / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000235:genetics*; D012307:Risk Factors; D012694:Serine / Q000235:genetics; D014421:Turkey
chemical_list: D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic; D012694:Serine; D005998:Glycine