title: Risk factors and clinical outcomes of childhood ischemic stroke in a single Korean tertiary care center.
abstract: A 10-year, retrospective review of the risk factors and clinical outcome of childhood ischemic stroke treated in a single tertiary care center was conducted. Sixty-two children were identified (33 boys and 29 girls), ages 1 month to 17 years. Risk factors included vasculopathy (35.5%), cardiac disease (17.4%), metabolic disorder (14.5%), infection (14.5%), and coagulopathy (1.6%). Nine patients (14.5%) had no identifiable cause of stroke and 1 patient had 2 risk factors. Hemiplegia (69.3%) and seizures (32.3%) were the most common presenting features, and seizures were significantly more frequent in children <12 months of age than in older children (71.4% vs 20.8%, P = .001). Recurrence of stroke occurred in 55.6% of patients with metabolic disorder, 33.3% of those with cardiac disease, and 19.0% of those with vasculopathy. Vasculopathy including moyamoya disease was the most important risk factor for ischemic stroke in Korea, and their prognosis were varied with the etiology of stroke.
authors.affiliation: Department of Pediatrics, Division of Pediatric Neurology, Asan Medical Center, Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Eun Hye
authors.initials: EH
authors.lastname: Lee
authors.forename: Mi-Sun
authors.initials: MS
authors.lastname: Yum
authors.forename: Tae-Sung
authors.initials: TS
authors.lastname: Ko
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002545:Brain Ischemia / Q000150:complications / Q000453:epidemiology*; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D053208:Kaplan-Meier Estimate; D008137:Longitudinal Studies; D008297:Male; D009069:Movement Disorders; D009072:Moyamoya Disease / Q000453:epidemiology; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D012640:Seizures / Q000453:epidemiology; D020521:Stroke / Q000453:epidemiology* / Q000209:etiology*; D014652:Vascular Diseases / Q000453:epidemiology