title: Erdheim-Chester disease of the central nervous system: new manifestations of a rare disease.
abstract: OBJECTIVE
  ECD is a rare non-Langerhans-cell histiocytosis, which can involve the CNS; therefore, CNS imaging findings have been described in only a small number of patients. To gain additional insight into the CNS manifestations of ECD, we reviewed the findings on imaging of the brain, head and neck, and spine in patients with ECD who presented to our institution. Here, we illustrate manifestations that have not, to our knowledge, been previously described.
  
  
  METHODS
  CT, MR imaging, and PET/CT studies of the brain, maxillofacial region, and spine were reviewed in 11 patients with ECD.
  
  
  RESULTS
  Four new manifestations of ECD were present, including the following: a stellate appearance of intracranial extra-axial lesions, ependymal enhancement along the lateral ventricle with deep linear extension to the lentiform nucleus, irregular enhancement in the pons, and diffuse involvement of the vertebral column on PET/CT.
  
  
  CONCLUSIONS
  ECD has a variety of imaging appearances in the CNS, including new manifestations described herein. Neuroradiologists should be aware of these manifestations to avoid mistaking them for other disease processes.
authors.affiliation: Universityof Texas MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: P
authors.initials: P
authors.lastname: Sedrak
authors.forename: L
authors.initials: L
authors.lastname: Ketonen
authors.forename: P
authors.initials: P
authors.lastname: Hou
authors.forename: N
authors.initials: N
authors.lastname: Guha-Thakurta
authors.forename: M D
authors.initials: MD
authors.lastname: Williams
authors.forename: R
authors.initials: R
authors.lastname: Kurzrock
authors.forename: J M
authors.initials: JM
authors.lastname: Debnam
mesh_terms: D000328:Adult; D000368:Aged; D001927:Brain Diseases / Q000175:diagnosis*; D003952:Diagnostic Imaging / Q000379:methods*; D031249:Erdheim-Chester Disease / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D019767:Maxillofacial Abnormalities / Q000175:diagnosis*; D008875:Middle Aged; D035583:Rare Diseases; D013122:Spinal Diseases / Q000175:diagnosis*