title: Estrogen dependent signaling in reproductive tissues - a role for estrogen receptors and estrogen related receptors.
abstract: Estrogens play a fundamental role in the development and normal physiological function of multiple tissue systems and have been implicated in the ontogeny of cancers. The biological effects of estrogens are classically mediated via interaction with cognate nuclear receptors. The relative expression of ER subtypes/variants varies between cells within different tissues and this alters the response to natural and synthetic ligands. This review focuses on the role of estrogen and estrogen related receptors in reproductive tissues.
authors.affiliation: MRC/UoE Centre for Reproductive Health, The University of Edinburgh, The Queen's Medical Research Institute, Edinburgh EH16 4TJ, UK.
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Gibson
authors.forename: Philippa T K
authors.initials: PT
authors.lastname: Saunders
mesh_terms: D000818:Animals; D004967:Estrogens; D018507:Gene Expression Regulation, Developmental; D005835:Genitalia / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D006801:Humans; D020033:Protein Isoforms / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D017434:Protein Structure, Tertiary; D011960:Receptors, Estrogen / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D004967:Estrogens; D020033:Protein Isoforms; D011960:Receptors, Estrogen