title: Spindle positioning: going against the actin flow.
abstract: Successful completion of meiosis in vertebrate oocytes requires the localization and maintenance of the meiotic spindle at the cell cortex. Arp2/3-nucleated actin filaments are now shown to flow away from the cortex overlying the spindle, resulting in cytoplasmic streaming, which maintains the spindle in its asymmetric position.
authors.affiliation: Collège de France, Center for Interdisciplinary Research in Biology, UMR-CNRS7241/INSERM-U1050, 11 place Marcelin Berthelot, 75005 Paris, France. marie-helene.verlhac@college-de-france.fr
authors.forename: Marie-Hélène
authors.initials: MH
authors.lastname: Verlhac
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism*; D051377:Actin-Related Protein 2 / Q000378:metabolism*; D051376:Actin-Related Protein 2-3 Complex / Q000378:metabolism*; D051378:Actin-Related Protein 3 / Q000378:metabolism*; D000818:Animals; D003595:Cytoplasmic Streaming; D005260:Female; D008540:Meiosis; D009865:Oocytes / Q000378:metabolism*; D008941:Spindle Apparatus / Q000378:metabolism*
chemical_list: D051377:Actin-Related Protein 2; D051376:Actin-Related Protein 2-3 Complex; D051378:Actin-Related Protein 3; C495927:Actr2 protein, mouse; C495929:Actr3 protein, mouse