title: Targeted therapy of SMMC-7721 liver cancer in vitro and in vivo with carbon nanotubes based drug delivery system.
abstract: A new type of drug delivery system (DDS) involved chitosan (CHI) modified single walled carbon nanotubes (SWNTs) for controllable loading/release of anti-cancer doxorubicin (DOX) was constructed. CHI was non-covalently wrapped around SWNTs, imparting water-solubility and biocompatibility to the nanotubes. Folic acid (FA) was also bounded to the outer CHI layer to realize selective killing of tumor cells. The targeting DDS could effectively kill the HCC SMMC-7721 cell lines and depress the growth of liver cancer in nude mice, showing superior pharmaceutical efficiency to free DOX. The results of the blood routine and serum biochemical parameters, combined with the histological examinations of vital organs, demonstrating that the targeting DDS had negligible in vivo toxicity. Thus, this DDS is promising for high treatment efficacy and low side effects for future cancer therapy.
authors.affiliation: Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China.
authors.forename: Zongfei
authors.initials: Z
authors.lastname: Ji
authors.forename: Gaofeng
authors.initials: G
authors.lastname: Lin
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Lu
authors.forename: Lingjie
authors.initials: L
authors.lastname: Meng
authors.forename: Xizhong
authors.initials: X
authors.lastname: Shen
authors.forename: Ling
authors.initials: L
authors.lastname: Dong
authors.forename: Chuanlong
authors.initials: C
authors.lastname: Fu
authors.forename: Xiaoke
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000009:adverse effects / Q000494:pharmacology*; D016503:Drug Delivery Systems; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D037742:Nanotubes, Carbon; D023041:Xenograft Model Antitumor Assays
chemical_list: D000903:Antibiotics, Antineoplastic; D037742:Nanotubes, Carbon; D004317:Doxorubicin