title: Multimodal imaging of spike propagation: a technical case report.
abstract: We report an 11-year-old boy with intractable epilepsy, who had cortical dysplasia in the right superior frontal gyrus. Spatiotemporal source analysis of MEG and EEG spikes demonstrated a similar time course of spike propagation from the superior to inferior frontal gyri, as observed on intracranial EEG. The tractography reconstructed from DTI showed a fiber connection between these areas. Our multimodal approach demonstrates spike propagation and a white matter tract guiding the propagation.
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging,, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA. naoro@nmr.mgh.harvard.ed
authors.forename: N
authors.initials: N
authors.lastname: Tanaka
authors.forename: P E
authors.initials: PE
authors.lastname: Grant
authors.forename: N
authors.initials: N
authors.lastname: Suzuki
authors.forename: J R
authors.initials: JR
authors.lastname: Madsen
authors.forename: A M
authors.initials: AM
authors.lastname: Bergin
authors.forename: M S
authors.initials: MS
authors.lastname: Hämäläinen
authors.forename: S M
authors.initials: SM
authors.lastname: Stufflebeam
mesh_terms: D000200:Action Potentials; D002540:Cerebral Cortex / Q000473:pathology* / Q000503:physiopathology*; D002648:Child; D056324:Diffusion Tensor Imaging / Q000379:methods*; D004569:Electroencephalography / Q000379:methods*; D004827:Epilepsy / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods*; D008297:Male; D009415:Nerve Net / Q000473:pathology / Q000503:physiopathology; D009434:Neural Pathways / Q000473:pathology / Q000503:physiopathology; D013382:Subtraction Technique