title: Primary cutaneous, composite, Epstein-Barr virus-associated, diffuse large B-cell lymphoma and peripheral T-cell lymphoma.
abstract: T-cell lymphomas have a broad spectrum of cutaneous involvement. Several subtypes of T-cell lymphomas are associated with Epstein-Barr virus (EBV)-driven lymphoproliferative processes. We present a case of a composite, primary, cutaneous, EBV-associated, diffuse, large B-cell lymphoma and mature T-cell lymphoma occurring in a patient with Klinefelter karyotype (47, XXY). The patient had a characteristic clinical course of a systemic mature T-cell lymphoma before the presentation of the composite, primary, EBV-associated, diffuse, large B-cell lymphoma. Although similar cases have been described in extracutaneous locations, we believe that this is the first description with a primary cutaneous presentation.
authors.affiliation: Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA. papal002@mc.duke.edu
authors.forename: John A
authors.initials: JA
authors.lastname: Papalas
authors.forename: Puja K
authors.initials: PK
authors.lastname: Puri
authors.forename: Siby
authors.initials: S
authors.lastname: Sebastian
authors.forename: Endi
authors.initials: E
authors.lastname: Wang
mesh_terms: D020031:Epstein-Barr Virus Infections / Q000473:pathology*; D006801:Humans; D007713:Klinefelter Syndrome / Q000150:complications; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology* / Q000821:virology; D016411:Lymphoma, T-Cell, Peripheral / Q000473:pathology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000821:virology; D012878:Skin Neoplasms / Q000473:pathology* / Q000821:virology