title: Tirucallane-type triterpenoids from Dysoxylum lenticellatum.
abstract: Ten new tirucallane-type triterpenoids, represented by a rearranged skeleton dysolenticin A (1), dysolenticin B (2), a rare trinortriterpenoid dysolenticin C (3), three tirucallane triterpenoid derivatives with a hemiketal moiety dysolenticins D-F (4-6), dysolenticins G-I (7, 9, 10), and the new alkaloid dysolenticin J (12), together with seven known analogues were isolated from the twigs and leaves of Dysoxylum lenticellatum. Their structures were elucidated by extensive spectroscopic methods, and those of compounds 1, 3, 4, 6, and 10 were confirmed by single-crystal X-ray diffraction experiments. Dysolenticin J (12) showed significant vasodilative effects on intact rat aortic rings with a diastolic degree of 87.4% at 10 μg/mL.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China.
authors.forename: Hong-Li
authors.initials: HL
authors.lastname: Huang
authors.forename: Chun-Ming
authors.initials: CM
authors.lastname: Wang
authors.forename: Zhen-Hua
authors.initials: ZH
authors.lastname: Wang
authors.forename: Ming-Jun
authors.initials: MJ
authors.lastname: Yao
authors.forename: Guang-Tian
authors.initials: GT
authors.lastname: Han
authors.forename: Ji-Cheng
authors.initials: JC
authors.lastname: Yuan
authors.forename: Kun
authors.initials: K
authors.lastname: Gao
authors.forename: Cheng-Shan
authors.initials: CS
authors.lastname: Yuan
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D001011:Aorta / Q000187:drug effects; D018360:Crystallography, X-Ray; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D051381:Rats; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014665:Vasodilator Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D014315:Triterpenes; D014665:Vasodilator Agents; C569080:dysolenticin J; C514393:tirucallane