title: Strategies for B-lymphocyte repertoire remodeling in transplantation tolerance.
abstract: Transplantation tolerance remains an elusive goal as B-cell-initiated chronic humoral rejection evades current immunosuppression. B-cell-directed therapy is thus emerging as a key component in achieving transplantation tolerance and long-term graft survival. Here, we propose strategies of B-cell repertoire remodeling to achieve humoral unresponsiveness to donor antigens with implementation of fundamental B-cell immunobiology and use of newly developed B-cell-directed agents.
authors.affiliation: Harrison Department of Surgical Research, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
authors.forename: Kumar
authors.initials: K
authors.lastname: Vivek
authors.forename: Moiz M
authors.initials: MM
authors.lastname: Mustafa
authors.forename: Eduardo
authors.initials: E
authors.lastname: Rodriguez
authors.forename: Robert R
authors.initials: RR
authors.lastname: Redfield
authors.forename: Ronald F
authors.initials: RF
authors.lastname: Parsons
authors.forename: Susan
authors.initials: S
authors.lastname: Rostami
authors.forename: Thi-Sau
authors.initials: TS
authors.lastname: Migone
authors.forename: Michael P
authors.initials: MP
authors.lastname: Cancro
authors.forename: Ali
authors.initials: A
authors.lastname: Naji
authors.forename: Hooman
authors.initials: H
authors.lastname: Noorchashm
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology; D006084:Graft Rejection / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control*; D006085:Graft Survival / Q000276:immunology*; D006801:Humans; D018448:Models, Immunological; D023001:Transplantation Tolerance / Q000276:immunology*