title: [Effect of Eupolyphaga fibrinolytic protein on microvessel density and the expression of vascular endothelial growth factor in mice tumor].
abstract: OBJECTIVE
  To study the effect of Eupolyphaga fibrinolyric protein (EFP) on microvessel density (MVD) and the expression of vascular endthelial growth factor in transplantation S180 and H22 mice.
  
  
  METHODS
  The MVD in tumor was measured with immunohistochemical SP method and the VEGF level in serum was measured with ELISA method.
  
  
  RESULTS
  Compared with the control group, EFP could significantly reduce the microvessel density and decrease the expression of vascular endothelial growth factor.
  
  
  CONCLUSIONS
  EFP has the effect of anti-angiogenesis.
authors.affiliation: Bioengineering Dept, Faculty of light and Chemical, Guangdong University of Technology, Guangzhou 510006, China.
authors.forename: Fu-Chun
authors.initials: FC
authors.lastname: Cao
authors.forename: Ya-Li
authors.initials: YL
authors.lastname: Han
authors.forename: Bing
authors.initials: B
authors.lastname: Chen
authors.forename: Hao
authors.initials: H
authors.lastname: Liu
authors.forename: Hong
authors.initials: H
authors.lastname: Ding
authors.forename: Ming-Xing
authors.initials: MX
authors.lastname: Huang
authors.forename: Yun
authors.initials: Y
authors.lastname: Ye
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D018952:Antigens, CD34 / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000098:blood supply / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D003058:Cockroaches / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D042783:Endothelial Cells / Q000378:metabolism; D005260:Female; D007150:Immunohistochemistry; D019476:Insect Proteins / Q000494:pharmacology*; D008113:Liver Neoplasms / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D051379:Mice; D055806:Microvessels / Q000473:pathology; D009368:Neoplasm Transplantation; D009389:Neovascularization, Pathologic; D012510:Sarcoma 180 / Q000098:blood supply / Q000378:metabolism / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000097:blood* / Q000378:metabolism
chemical_list: D020533:Angiogenesis Inhibitors; D018952:Antigens, CD34; D019476:Insect Proteins; D042461:Vascular Endothelial Growth Factor A