title: An evaluation of P50 paired-click methodologies.
abstract: The utility of P50 paired-click measures is limited by their unestablished reliability, unknown effects of time, and long protocol. This study measured within-session reliability, temporal course, effect of varying interpair interval (IPI), and peak definition and ratio calculation methods on P50 paired-click measures in healthy participants. Results indicate higher reliability for difference (ICC=.72) than ratio (ICC=.44) method; when P50 peaks are defined as baseline-to-peak than peak-to-peak; time-related changes; and comparable P50 paired-click measures at long (9 s) and short (3-7 s) IPIs. After controlling for time effects, P50 paired-click measures are relatively reliable within-session and are best measured using the difference method and defined as baseline-to-peak amplitude; time effects must be taken into account when measuring P50 paired-click measures in a long paradigm; and IPI can be shortened in studies with healthy samples.
authors.affiliation: School of Psychology, University of Wollongong, Wollongong, Australia.
authors.forename: Anna
authors.initials: A
authors.lastname: Dalecki
authors.forename: Rodney J
authors.initials: RJ
authors.lastname: Croft
authors.forename: Stuart J
authors.initials: SJ
authors.lastname: Johnstone
mesh_terms: D000161:Acoustic Stimulation; D003627:Data Interpretation, Statistical; D004569:Electroencephalography / Q000379:methods*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000175:diagnosis*; D012569:Schizotypal Personality Disorder / Q000523:psychology; D055139:Sensory Gating / Q000502:physiology; D055815:Young Adult