title: Decrease of serum chemerin concentration in patients with end stage renal disease after successful kidney transplantation.
abstract: Chemerin is an adipokine associated with metabolic syndrome, systemic inflammation and innate immune system. It has been suggested recently that the decrease in renal function may cause an increase in serum chemerin concentration. In this paper we investigated the effect of kidney transplantation on elevated serum chemerin concentration in dialyzed patients with end stage renal disease (ESRD). Twenty five ESRD patients were tested before and 3months after the kidney transplantation. The control group was comprised of twenty one healthy subjects. Serum chemerin concentrations were measured using commercial ELISA kit, and were related to clinical status, and biomarkers of renal function. We have shown that the kidney transplantation resulted in the decrease of the serum chemerin concentration. Concomitantly, serum creatinine, blood urea nitrogen, phosphate and C-reactive protein concentrations were significantly reduced, while estimated glomerular filtration rate (eGFR), calcium and hemoglobin substantially increased. Univariate regression analysis showed that serum chemerin concentration was positively correlated with serum creatinine and phosphate concentrations and negatively correlated with eGFR. The results presented here indicate that the serum chemerin concentration in patients with ESRD normalizes after the kidney transplantation, and provide additional evidence that serum chemerin concentration is related to renal function.
authors.affiliation: Department of Nephrology, Transplantation and Internal Medicine, Medical University of Gdansk, Gdansk, Poland.
authors.forename: Przemyslaw
authors.initials: P
authors.lastname: Rutkowski
authors.forename: Tomasz
authors.initials: T
authors.lastname: Sledzinski
authors.forename: Hanna
authors.initials: H
authors.lastname: Zielinska
authors.forename: Slawomir
authors.initials: S
authors.lastname: Lizakowski
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Goyke
authors.forename: Sylwia
authors.initials: S
authors.lastname: Szrok-Wojtkiewicz
authors.forename: Julian
authors.initials: J
authors.lastname: Swierczynski
authors.forename: Bolesław
authors.initials: B
authors.lastname: Rutkowski
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D018925:Chemokines / Q000097:blood*; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D007668:Kidney / Q000503:physiopathology / Q000601:surgery; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D020127:Recovery of Function; D055815:Young Adult
chemical_list: D015415:Biomarkers; D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human; D003404:Creatinine