title: Vancomycin storage stability in multilayer thin film coatings for on-demand care.
abstract: A rise in drug-resistant bacteria coupled with a decline in the development of new classes of antibiotics has increased the need for new local antibiotic delivery methods. To address this need, we have previously developed layer-by-layer assembled films releasing the potent antibiotic, vancomycin, for use as coatings for on-demand care. In this work, we explore the potential for practical application of these films through an in-depth study of their long term storage stability over a wide range of temperatures, including refrigerator, room and elevated temperature (4, 25 and 37°C, respectively). Our results indicate that the drug-release profiles and minimum inhibitory concentration against Staphylococcus aureus of vancomycin released from films stored at these different conditions are not affected over a period of 1-6 months. Consequently, these films can be used where traditional refrigeration of prepared intravenous vancomycin solutions or immediate reconstitution of lyophilized vancomycin is not possible.
authors.affiliation: a Department of Chemical Engineering , Massachusetts Institute of Technology , 66-352, 77 Massachusetts Avenue , Cambridge , MA , 02139 , USA.
authors.forename: Anita
authors.initials: A
authors.lastname: Shukla
authors.forename: Sravanthi
authors.initials: S
authors.lastname: Puranam
authors.forename: Paula T
authors.initials: PT
authors.lastname: Hammond
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D016503:Drug Delivery Systems; D065546:Drug Liberation; D004355:Drug Stability; D004356:Drug Storage; D008422:Materials Testing; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects; D013696:Temperature; D013997:Time Factors; D014640:Vancomycin / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D014640:Vancomycin