title: Storage time of blood products and transfusion-related acute lung injury.
abstract: BACKGROUND
  Besides white blood cell antibodies in plasma-rich products, another cause of transfusion-related acute lung injury (TRALI) could be release of biologically active substances during storage of cellular blood products. We aimed to investigate the association of storage time and risk of TRALI for different product types.
  
  
  METHODS
  We compared storage time of blood products transfused within 6 hours before the onset of TRALI to storage time of a representative sample of all blood products transfused in the Netherlands. Generalized linear models were used to correct for confounding variables.
  
  
  RESULTS
  Platelets (PLTs) in plasma transfused to TRALI patients were stored for 0.7 (95% confidence interval [CI], 0.073 to 1.3) days longer than those transfused to controls. The relative risk of TRALI, after receiving PLTs stored for 4 or 5 days, compared to 3 days or less, was 5.8 (95% CI, 0.99 to 110) and increased to 6.3 (95% CI, 1.1 to 118) after more than 5 days (i.e., 6 or 7 days).
  
  
  CONCLUSIONS
  While longer storage of buffy coat-derived PLTs was associated with an increased risk of TRALI, storage of plasma for up to 2 years and red blood cells for up to 35 days was not associated with the risk of TRALI.
authors.affiliation: Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands. R.Middelburg@Sanquin.nl
authors.forename: Rutger A
authors.initials: RA
authors.lastname: Middelburg
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Borkent-Raven
authors.forename: Barbara
authors.initials: B
authors.lastname: Borkent
authors.forename: Mart P
authors.initials: MP
authors.lastname: Janssen
authors.forename: Mart
authors.initials: M
authors.lastname: Jansen
authors.forename: Leo M G
authors.initials: LM
authors.lastname: van de Watering
authors.forename: Johanna C
authors.initials: JC
authors.lastname: Wiersum-Osselton
authors.forename: Martin R
authors.initials: MR
authors.lastname: Schipperus
authors.forename: Erik A M
authors.initials: EA
authors.lastname: Beckers
authors.forename: Ernest
authors.initials: E
authors.lastname: Briët
authors.forename: Johanna G
authors.initials: JG
authors.lastname: van der Bom
mesh_terms: D055371:Acute Lung Injury / Q000453:epidemiology* / Q000209:etiology; D058621:Blood Buffy Coat; D016913:Blood Component Transfusion / Q000009:adverse effects* / Q000706:statistics & numerical data*; D001793:Blood Preservation / Q000009:adverse effects* / Q000379:methods / Q000706:statistics & numerical data*; D006801:Humans; D016014:Linear Models; D015999:Multivariate Analysis; D009426:Netherlands / Q000453:epidemiology; D053657:Platelet-Rich Plasma; D012307:Risk Factors; D013997:Time Factors