title: Comparison of focally induced epileptiform activities in C57BL/6 and BALB/c mice by using in vivo EEG recording.
abstract: Epilepsy characterized by repeated seizures is influenced by genetic factors. Seizure response of inbred mouse strains changes depending on the variety of stimuli including chemical (e.g., pentylenetetrazole, nicotine, cocaine, NMDA, kainate), physical (e.g., auditory) or electrical. In this study, we compared the susceptibilities of C57BL/6 and BALB/c mice strains to penicillin induced epileptiform activity (a focally induced, experimental epilepsy model), by analyzing the spike onset latency, spike amplitude and spike frequency. The power spectrums of baseline EEGs were also investigated. We found no alterations of spike onset latencies between the C57 and BALB mice. However, spike amplitudes and spike frequencies were found to be higher in BALB mice than C57 mice. With regard to EEG power spectrum, absolute power of investigated bands was not different between the two strains. Interestingly, the relative power of all investigated bands differed significantly between two strains. The relative power of delta and theta was lower whereas relative power of alpha, beta and gamma was higher in C57 mice compared to BALB mice. In conclusion, our findings showed that BALB mice are more sensitive to penicillin induced epileptiform activity when compared to C57 strain.
authors.affiliation: Department of Biophysics, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey. Electronic address: selcenaydin@yahoo.com.
authors.forename: Selcen
authors.initials: S
authors.lastname: Aydin-Abidin
authors.affiliation: Department of Physiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yildirim
authors.affiliation: Department of Biophysics, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
authors.forename: İsmail
authors.initials: İ
authors.lastname: Abidin
authors.affiliation: Department of Physiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Metehan
authors.initials: M
authors.lastname: Akca
authors.affiliation: Department of Pediatric Neurology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Cansu
mesh_terms: D000513:Alpha Rhythm / Q000187:drug effects / Q000502:physiology; D000818:Animals; D003627:Data Interpretation, Statistical; D003700:Delta Rhythm / Q000187:drug effects; D004558:Electric Stimulation; D004569:Electroencephalography / Q000187:drug effects; D004827:Epilepsy / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010406:Penicillins; D013045:Species Specificity
chemical_list: D010406:Penicillins