title: Dietary antioxidant supplements: benefits of their combined use.
abstract: Several dietary supplements claim medicinal benefits due to their composition in hydrophilic and lipophilic molecules, natural extracts or synthetic compounds with antioxidant properties. In the present work, the antioxidant activity of selected supplements taken in pills, capsules or infusions were studied either individually or combined. Linear discriminant analysis (LDA) was used to categorize the condensed formulations (pills and capsules), infusion bags and combined samples according with their antioxidant activity measured by radical scavenging activity, reducing power and lipid peroxidation inhibition using brain homogenates as models. AAF proved to have the highest antioxidant activity in all the assayed methods, either singly taken or included in mixtures. Furthermore, the mixtures containing this supplement revealed synergistic effects in 92% of the cases. The intake of antioxidant mixtures might provide some additional benefits.
authors.affiliation: REQUIMTE/ Depto. de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Aníbal Cunha, 164, 4050-047 Porto, Portugal.
authors.forename: Ivone M C
authors.initials: IM
authors.lastname: Almeida
authors.forename: João C M
authors.initials: JC
authors.lastname: Barreira
authors.forename: M Beatriz P P
authors.initials: MB
authors.lastname: Oliveira
authors.forename: Isabel C F R
authors.initials: IC
authors.lastname: Ferreira
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D001713:Biphenyl Compounds / Q000008:administration & dosage*; D001921:Brain / Q000378:metabolism; D019587:Dietary Supplements; D004338:Drug Combinations; D004357:Drug Synergism; D016014:Linear Models; D015227:Lipid Peroxidation / Q000187:drug effects; D010851:Picrates / Q000008:administration & dosage*; D010936:Plant Extracts / Q000008:administration & dosage*; D034421:Sus scrofa; D013607:Tablets; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D004338:Drug Combinations; D010851:Picrates; D010936:Plant Extracts; D013607:Tablets; D017392:Thiobarbituric Acid Reactive Substances; C004931:1,1-diphenyl-2-picrylhydrazyl