title: Stable and orally bio-available pro-drugs of CPS11.
abstract: Stable and orally bio-available pro-drugs of CPS11 were synthesized. They are active on human umbilical vein endothelial cell proliferation assay and tube formation assay. The therapeutic efficacy and safety of 4 as a single agent or combined with Taxol in the treatment of MX-1 human breast cancer xenograft were evaluated. Compound 4 as a single agent failed to produce an anti-tumor activity, while it significantly enhanced antitumor potency of Taxol.
authors.affiliation: Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China.
authors.forename: Aihong
authors.initials: A
authors.lastname: Huo
authors.forename: Hesheng
authors.initials: H
authors.lastname: Zhang
authors.forename: Yongbiao
authors.initials: Y
authors.lastname: Guan
authors.forename: Guanghuai
authors.initials: G
authors.lastname: Zeng
authors.forename: Yingwei
authors.initials: Y
authors.lastname: Chen
authors.forename: Xingwen
authors.initials: X
authors.lastname: Li
mesh_terms: D001682:Biological Availability; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D004355:Drug Stability; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects; D005260:Female; D006801:Humans; D011355:Prodrugs / Q000493:pharmacokinetics*; D013792:Thalidomide / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D014471:Umbilical Veins / Q000166:cytology / Q000187:drug effects; D023041:Xenograft Model Antitumor Assays
chemical_list: C494620:CPS 11; D011355:Prodrugs; D013792:Thalidomide