title: Creatine supplementation does not augment muscle carnosine content in type 2 diabetic patients.
abstract: We examined whether creatine supplementation affects muscle carnosine content in type 2 diabetic patients. Subjects were randomly assigned to receive either creatine (5 g·day(-1)) or placebo in a double-blind fashion. At baseline and after 12 weeks, carnosine content was evaluated in gastrocnemius and soleus muscles by using a 1H-MRS technique. No changes were found in gastrocnemius (p = 0.81) and soleus (p = 0.85). We concluded that creatine supplementation does not augment muscle carnosine content in type 2 diabetic patients.
authors: School of Physical Education and Sport, School of Medicine, University of Sao Paulo, Av Mello de Moraes, Sao Paulo, SP, Brazil. gualano@usp.br
authors: Bruno
authors: B
authors: Gualano
authors: Rebeca
authors: R
authors: Lugaresi
authors: Vitor
authors: V
authors: de Salles Painelli
authors: Vitor
authors: V
authors: Painelli de Salles
authors: Andréia Cristina Carrenho
authors: AC
authors: Queiroz
authors: Guilherme
authors: G
authors: Artioli
authors: Hamilton
authors: H
authors: Roschel
authors: Maria Concepción
authors: MC
authors: Otaduy
authors: Cláudia da Costa
authors: Cda C
authors: Leite
authors: Antonio Herbert
authors: AH
authors: Lancha
mesh_terms: D015992:Body Mass Index; D003401:Creatine / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000628:therapy; D019587:Dietary Supplements; D004311:Double-Blind Method; D015444:Exercise; D005260:Female; D006801:Humans; D007866:Leg; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D018656:Muscle Fibers, Fast-Twitch / Q000378:metabolism; D018657:Muscle Fibers, Slow-Twitch / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism*
chemical_list: D003401:Creatine