title: Development of an electronic decision tool to support appropriate treatment choice in adult patients with epilepsy--Epi-Scope(®).
abstract: BACKGROUND
  Given the continuous knowledge progression and the growing number of available antiepileptic drugs (AEDs), making appropriate treatment choices for patients with epilepsy is increasingly difficult. While published guidelines help for separate clinical aspects, patients with a combination of specific characteristics may escape proper guidance. This study aimed to determine the appropriateness of AEDs for particular clinical variables and to offer treatment recommendations for adult patients with epilepsy in a user-friendly format for practicing neurologists.
  
  
  METHODS
  Using the RAND/UCLA Appropriateness Method, the appropriateness of AEDs as initial/second mono-therapy and combination therapy was assessed in relation to selected clinical variables by a Belgian panel of 13 experts in epilepsy. Panel recommendations for particular patient profiles were determined by the outcome of these separate ratings.
  
  
  RESULTS
  The appropriateness outcome of individual AEDs was not substantially different between first and second mono-therapy; valproate was considered appropriate for all types of generalised and partial seizures. The outcome for combination therapy was highly dependent on the type of AED and seizures. With respect to co-morbidities and co-treatments, levetiracetam and pregabalin proved to have the least contra-indications. For the elderly and with respect to factors related to the female reproductive system the appropriateness of AEDs showed a more diffuse pattern. Although caution was deemed necessary for some combinations, the AEDs were never considered inappropriate regarding their drug interaction profile.
  
  
  CONCLUSIONS
  The Epi-Scope(®) tool that displays appropriateness recommendations for highly specific, possibly complex cases, supports optimal treatment choices for adult patients with epilepsy in daily practice.
authors: Hôpital Erasme, Université Libre de Bruxelles, Centre de Référence Pour le Traitement de l'Épilepsie Réfractaire, 808, Route de Lennik, 1070 Bruxelles, Belgium. blegros@ulb.ac.be
authors: Benjamin
authors: B
authors: Legros
authors: Paul
authors: P
authors: Boon
authors: Berten
authors: B
authors: Ceulemans
authors: Thomas
authors: T
authors: Coppens
authors: Karine
authors: K
authors: Geens
authors: Henri
authors: H
authors: Hauman
authors: Lieven
authors: L
authors: Lagae
authors: Alfred
authors: A
authors: Meurs
authors: Leon
authors: L
authors: Mol
authors: Michel
authors: M
authors: Ossemann
authors: Kenou
authors: K
authors: van Rijckevorsel
authors: Michel
authors: M
authors: Van Zandijcke
authors: Pascal
authors: P
authors: Vrielynck
authors: Daniëlla
authors: D
authors: Wagemans
authors: Thierry
authors: T
authors: Grisar
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D003661:Decision Support Techniques; D004827:Epilepsy / Q000188:drug therapy*; D005103:Expert Systems; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014584:User-Computer Interface; D055815:Young Adult
chemical_list: D000927:Anticonvulsants