title: The sustained influence of short term exposure to a proprietary extract of North American ginseng on the hemopoietic cells of the bone marrow, spleen and blood of adult and juvenile mice.
abstract: This study assessed the influences of CVT-E002, a proprietary extract of North American ginseng, Panax quinquefolius (Afexa Life Sciences, Inc., Edmonton, AB, Canada), in vivo, on murine hemopoietic and immune cells when administered as a dietary additive. The extract was given daily to young, adult mice for a period of 4 weeks, immediately following which one group was euthanized and the hemopoietic and immune cells of their bone marrow, spleen and blood were assayed for CVT-E002-mediated alterations in any of five cell lineages (lymphocytes, nucleated erythroid cells, granulocytes, immature granuloid precursors and monocytes). Another group of these mice was left for a subsequent 8 weeks on control diet, following which the same organs and cell lineages were analysed. In another study, juvenile mice immediately upon weaning (age: 4 weeks), were subjected to the above protocol, and their organs/cell lineages assayed. The results revealed that CVT-E002 had a long-lasting, positive quantitative effect on the lymphocytes and monocytes, regardless of age at commencement of daily, dietary CVT-E002. CVT-E002 may therefore have a prophylactic disease defense, immunostimulatory role, or potentially, even a therapeutic role.
authors: Department of Anatomy and Cell Biology, McGill University, Montreal, QC, Canada. sandra.miller@mcgill.ca
authors: Sandra C
authors: SC
authors: Miller
authors: Lianping
authors: L
authors: Ti
authors: Jacqueline J
authors: JJ
authors: Shan
mesh_terms: D000276:Adjuvants, Immunologic / Q000097:blood / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D001853:Bone Marrow / Q000187:drug effects / Q000276:immunology; D001854:Bone Marrow Cells / Q000187:drug effects; D019587:Dietary Supplements; D041905:Erythroid Cells / Q000187:drug effects; D005260:Female; D006098:Granulocytes / Q000187:drug effects; D006410:Hematopoiesis / Q000187:drug effects*; D007113:Immunity, Innate / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice; D008809:Mice, Inbred C3H; D009000:Monocytes / Q000187:drug effects; D005894:Panax / Q000737:chemistry*; D010936:Plant Extracts / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D011247:Pregnancy; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013997:Time Factors
chemical_list: D000276:Adjuvants, Immunologic; C511203:COLD-fX; D010936:Plant Extracts