title: The Effect of Antiretroviral Combination Treatment on Epstein-Barr Virus (EBV) Genome Load in HIV-Infected Patients.
abstract: We evaluated the effect of combination anti-retroviral treatment (cART) on the host control of EBV infection in moderately immunosuppressed HIV-1 patients. Twenty HIV-1 infected individuals were followed for five years with repeated measurements of EBV DNA load in peripheral blood lymphocytes in relation to HIV-RNA titers and CD4+ cell counts. Individuals with optimal response, i.e. durable non-detectable HIV-RNA, showed a decline of EBV load to the level of healthy controls. Individuals with non-optimal HIV-1 control did not restore their EBV control. Long-lasting suppression of HIV-replication after early initiation of cART is a prerequisite for re-establishing the immune control of EBV.
authors: Microbiology and Tumor Biology Center, Karolinska Institute, SE-171 65 Stockholm, Sweden.
authors: Anna M C
authors: AMC
authors: Friis
authors: Gay Men's Health Clinic, Karolinska Institutet, Department of Clinical Science and Education, Södersjukhuset, SE-118 83 Stockholm, Sweden.
authors: Katarina
authors: K
authors: Gyllensten
authors: Microbiology and Tumor Biology Center, Karolinska Institute, SE-171 65 Stockholm, Sweden.
authors: Anna
authors: A
authors: Aleman
authors: Microbiology and Tumor Biology Center, Karolinska Institute, SE-171 65 Stockholm, Sweden.
authors: Ingemar
authors: I
authors: Ernberg
authors: Department of Infectious Diseases, Karolinska University Hospital, Huddinge, SE-141 86 Stockholm, Sweden.
authors: Börje
authors: B
authors: Åkerlund