title: Compounds from Arnebia euchroma and their related anti-HCV and antibacterial activities.
abstract: Three new hydroquinone terpenoids with benzogeijerene skeletons, euchroquinols A-C (1- 3), and a new monoterpenylbenzenoid, 9,17-epoxyarnebinol (4), along with five known compounds were isolated from the stem bark of ARNEBIA EUCHROMA. Shikonin (6) exhibited potent anti-HCV activity with a selective index of 43.56, and compounds 1, 6, and des-O-methyllasiodiplodin (7) showed anti-Staphylococcus aureus activity with MICs of 0.5, 0.125, and 0.125 mg/mL, respectively.
authors: The College of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, P. R. China.
authors: Hong-Mei
authors: HM
authors: Li
authors: Ying-Lei
authors: YL
authors: Tang
authors: Zhong-Hua
authors: ZH
authors: Zhang
authors: Chen-Jian
authors: CJ
authors: Liu
authors: Hai-Zhou
authors: HZ
authors: Li
authors: Rong-Tao
authors: RT
authors: Li
authors: Xue-Shan
authors: XS
authors: Xia
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology*; D028082:Boraginaceae / Q000737:chemistry*; D016174:Hepacivirus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009285:Naphthoquinones / Q000302:isolation & purification / Q000494:pharmacology; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018547:Plant Stems; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D009285:Naphthoquinones; D010936:Plant Extracts; C016101:shikonin