title: Discovery of highly potent small molecule Hepatitis C Virus entry inhibitors.
abstract: Novel, highly potent small molecule HCV entry inhibitors are reported. The SAR exploration of a hit molecule identified from screening of a compound library led to the identification of highly potent compounds with IC(50) values of <5 nM in the tissue culture HCV infectious assay.
authors: iTherX Pharmaceuticals, Inc., PO Box 910530, San Diego, CA 92191-0530, USA.
authors: Gopi Kumar
authors: GK
authors: Mittapalli
authors: Andrew
authors: A
authors: Jackson
authors: Fang
authors: F
authors: Zhao
authors: Haekyung
authors: H
authors: Lee
authors: Stephine
authors: S
authors: Chow
authors: Jeffrey
authors: J
authors: McKelvy
authors: Flossie
authors: F
authors: Wong-Staal
authors: James E
authors: JE
authors: Macdonald
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D055808:Drug Discovery; D016174:Hepacivirus / Q000187:drug effects* / Q000502:physiology; D006526:Hepatitis C / Q000188:drug therapy*; D006801:Humans; D020128:Inhibitory Concentration 50; D051381:Rats; D054852:Small Molecule Libraries / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D053586:Virus Internalization / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D054852:Small Molecule Libraries