title: The prognostic significance of malnutrition as assessed by the Mini Nutritional Assessment (MNA) in older hospitalized patients with a heavy disease burden.
abstract: OBJECTIVE
  Malnutrition is common in older persons. However, it is unclear whether malnutrition diagnosed with the Mini Nutritional Assessment (MNA) predicts mortality in older hospitalized patients.
  
  
  METHODS
  We prospectively studied the impact of the MNA-short form (MNA-SF) and co-morbidities on long-term mortality in 444 patients (mean age 85.3 ± 6.7; 74.0% women) receiving geriatric inpatient care. In a cross-sectional study we studied the interplay between the MNA, nutritional markers and co-morbidities (using the Cumulative Illness Rating Scale, CIRS).
  
  
  RESULTS
  The prevalence of malnutrition and "at risk of malnutrition", defined by MNA-SF, was 25.5 and 50.5% respectively in our prospective study. CIRS scores (HR = 1.09, p < 0.001) and a low BMI (HR = 0.96, p < 0.05), but not the MNA-SF (HR = 0.79 and 0.89 for "at risk" and malnutrition respectively, P = NS), were associated with 4-year mortality. CIRS scores, albumin and other nutritional markers were similar between MNA categories. High CIRS scores and hypoalbuminemia were observed even in patients with normal MNA scores. There was good agreement (>80%) between the MNA-SF and the complete MNA.
  
  
  CONCLUSIONS
  Malnutrition as diagnosed with the MNA at admission failed to predict long-term mortality in older inpatients, likely due to the overriding impact of co-morbidities and acute disease.
authors: Department of Internal Medicine, Rehabilitation and Geriatrics, Geneva University Hospitals and University of Geneva, Thônex, Switzerland. ulrich.vischer@hcuge.ch
authors: Ulrich M
authors: UM
authors: Vischer
authors: Emilia
authors: E
authors: Frangos
authors: Christophe
authors: C
authors: Graf
authors: Gabriel
authors: G
authors: Gold
authors: Lucien
authors: L
authors: Weiss
authors: François R
authors: FR
authors: Herrmann
authors: Dina
authors: D
authors: Zekry
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D015897:Comorbidity; D003430:Cross-Sectional Studies; D058620:Elder Nutritional Physiological Phenomena; D005260:Female; D015577:Geriatric Assessment; D006760:Hospitalization; D006801:Humans; D034141:Hypoalbuminemia / Q000453:epidemiology* / Q000503:physiopathology; D008297:Male; D044342:Malnutrition / Q000175:diagnosis / Q000453:epidemiology*; D015596:Nutrition Assessment; D011379:Prognosis; D011446:Prospective Studies; D018570:Risk Assessment