title: Superficial mycosis and the immune response elements.
abstract: Superficial mycoses are prevalent worldwide. They are often caused by dermatophytes and restricted to the stratum corneum. The host's immune response against infections caused by dermatophytes basically depends on the host's defense against metabolites of the fungi, virulence of the infecting strain or species and anatomical site of the infection. We will review some of the factors of the host's immune defense that influence the efficacy of the immune response. We will particularly review the role of pattern recognition receptors (PRRs), such as toll-like receptors or lectin receptors (DCSIGN and Dectin 2), which participate in the innate immune response, bringing specificity to the immune response and setting its pattern. The predominance of a cellular or humoral immune response determines the clinical manifestations and the prognosis of the infection, leading to healing or chronicity.
authors: Departamento de Dermatologia, Clinics Hospital, Faculdade de Medicina, Universidade de São Paulo, Brasil.
authors: Paulo Ricardo
authors: PR
authors: Criado
authors: Cristiane Beatriz de
authors: CB
authors: Oliveira
authors: Kátia Cristina
authors: KC
authors: Dantas
authors: Filomena Amaro
authors: FA
authors: Takiguti
authors: Luciana Vasconcellos
authors: LV
authors: Benini
authors: Cidia
authors: C
authors: Vasconcellos
mesh_terms: D003881:Dermatomycoses / Q000276:immunology*; D006790:Host-Parasite Interactions / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007113:Immunity, Innate / Q000276:immunology*; D012307:Risk Factors; D051193:Toll-Like Receptors / Q000276:immunology*
chemical_list: D051193:Toll-Like Receptors