title: Hypoxia, stem cells and bone tumor.
abstract: Normal oxygen level is critical for niches that together with other components of the niche play vital role in regulating stem or tumor cells behavior. Hypoxia plays an important role in normal development and disease progression, including the growth of solid tumors. The hypoxia inducible factors (HIFs) are the key mediators of the cellular response to hypoxia. In this review, we focused on the role of HIFs on bone tumor formation. Further, we also emphasized how hypoxia, stem cells, and its niches regulate the bone tumorigenesis.
authors: Department of Orthopaedics, Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, People's Republic of China.
authors: Wen
authors: W
authors: Zeng
authors: Rong
authors: R
authors: Wan
authors: Yuehuan
authors: Y
authors: Zheng
authors: Shree Ram
authors: SR
authors: Singh
authors: Yiyong
authors: Y
authors: Wei
mesh_terms: D001859:Bone Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology* / Q000556:secondary; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology; D015687:Cell Hypoxia / Q000502:physiology*; D002813:Chondrosarcoma / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism; D008297:Male; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000473:pathology; D012516:Osteosarcoma / Q000378:metabolism / Q000473:pathology; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology; D012512:Sarcoma, Ewing / Q000378:metabolism / Q000473:pathology; D013234:Stem Cells / Q000378:metabolism / Q000473:pathology
chemical_list: D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit