title: Synthesis of NP25302.
abstract: An efficient synthesis of NP25302 is presented that relies on 5-endo-dig N-cyclization to establish the bicyclic core and Curtius rearrangement to install the N-acyl vinylogous urea functionality.
authors: Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.
authors: Kiri
authors: K
authors: Stevens
authors: Andrew J
authors: AJ
authors: Tyrrell
authors: Sarah
authors: S
authors: Skerratt
authors: Jeremy
authors: J
authors: Robertson
mesh_terms: D003500:Cyclization; D008958:Models, Molecular; D015394:Molecular Structure; D011763:Pyrrolizidine Alkaloids / Q000138:chemical synthesis*; D014508:Urea / Q000737:chemistry; D014753:Vinyl Compounds / Q000737:chemistry
chemical_list: C478487:NP 25302; D011763:Pyrrolizidine Alkaloids; D014753:Vinyl Compounds; D014508:Urea