title: Low water intake and risk for new-onset hyperglycemia.
abstract: OBJECTIVE
  Water intake alters vasopressin secretion. Recent findings reveal an independent association between plasma copeptin, a surrogate for vasopressin, and risk of diabetes.
  
  
  METHODS
  Participants were 3,615 middle-aged men and women, with normal baseline fasting glycemia (FG), who were recruited in a 9-year follow-up study. Odds ratios (ORs) and 95% CIs for the incidence of hyperglycemia (FG ≥6.1 mmol/L or treatment for diabetes) were calculated according to daily water intake classes based on a self-administered questionnaire.
  
  
  RESULTS
  During follow-up, there were 565 incident cases of hyperglycemia. After adjustment for confounding factors, ORs (95% CIs) for hyperglycemia associated with classes of water intake (<0.5 L, n = 677; 0.5 to <1.0 L, n = 1,754; and >1.0 L, n = 1,184) were 1.00, 0.68 (0.52-0.89), and 0.79 (0.59-1.05), respectively (P = 0.016).
  
  
  CONCLUSIONS
  Self-reported water intake was inversely and independently associated with the risk of developing hyperglycemia.
authors: Université Paris–Diderot, Paris 7, Paris, France. ronan.roussel@bch.aphp.fr
authors: Ronan
authors: R
authors: Roussel
authors: Léopold
authors: L
authors: Fezeu
authors: Nadine
authors: N
authors: Bouby
authors: Beverley
authors: B
authors: Balkau
authors: Olivier
authors: O
authors: Lantieri
authors: François
authors: F
authors: Alhenc-Gelas
authors: Michel
authors: M
authors: Marre
authors: Lise
authors: L
authors: Bankir
mesh_terms: D000328:Adult; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000209:etiology*; D004326:Drinking; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006020:Glycopeptides / Q000097:blood; D006801:Humans; D006943:Hyperglycemia / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D012306:Risk
chemical_list: D006020:Glycopeptides; C048197:copeptins