title: Efficient neutralization of primary isolates by the plasma from HIV-1 infected Indian children.
abstract: We tested the plasma of 51 HIV-1-infected children (23 naïve and 28 ART treated) for neutralization against five primary isolates (PIs) generated from adult Indian HIV-1-infected patients. The plasma exhibited neutralization potential with significantly higher neutralizing antibody titers in ART-treated children than naïve children against three out of five PIs (p<0.0001). Further, in treated children, neutralizing antibody titers were higher in those children with suppressed viremia (<1000 RNA copies/mL) than non-suppressors against two of the three PIs. We report here for the first time the neutralization potential of the plasma of HIV-1-infected Indian children.
authors: Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
authors: S S
authors: SS
authors: Prakash
authors: Alok Kumar
authors: AK
authors: Chaudhary
authors: Rakesh
authors: R
authors: Lodha
authors: S K
authors: SK
authors: Kabra
authors: Madhu
authors: M
authors: Vajpayee
authors: Anjali
authors: A
authors: Hazarika
authors: Barun
authors: B
authors: Bagga
authors: Kalpana
authors: K
authors: Luthra
mesh_terms: D000293:Adolescent; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D057134:Antibodies, Neutralizing / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D015483:HIV Antibodies / Q000097:blood / Q000276:immunology*; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D009500:Neutralization Tests; D010949:Plasma / Q000276:immunology*
chemical_list: D019380:Anti-HIV Agents; D057134:Antibodies, Neutralizing; D015483:HIV Antibodies