title: The role of naïve T-cells in HIV-1 pathogenesis: an emerging key player.
abstract: Functional naïve T-cells are critical for an effective immune response to multiple pathogens. HIV leads to a significant reduction in CD4+ naïve T-cell number and impaired function and there is incomplete recovery following combination antiretroviral therapy (cART). Here we review the basic homeostatic mechanisms that maintain naïve CD4+ T-cells and discuss recent developments in understanding the impact of HIV infection on naïve CD4+ T-cells. Finally we review therapeutic interventions in HIV-infected individuals aimed at specifically enhancing recovery of naïve CD4+ T-cells.
authors: Department of Medicine, Monash University, Melbourne Victoria, 3004, Australia.
authors: Gabriela
authors: G
authors: Khoury
authors: Reena
authors: R
authors: Rajasuriar
authors: Paul U
authors: PU
authors: Cameron
authors: Sharon R
authors: SR
authors: Lewin
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D018925:Chemokines / Q000276:immunology; D002986:Clinical Trials as Topic; D003713:Dendritic Cells / Q000276:immunology / Q000821:virology; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007376:Interleukin-2 / Q000276:immunology / Q000627:therapeutic use; D015851:Interleukin-7 / Q000276:immunology / Q000627:therapeutic use; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D020395:Receptors, Interleukin-7 / Q000276:immunology
chemical_list: D019380:Anti-HIV Agents; D018925:Chemokines; D007376:Interleukin-2; D015851:Interleukin-7; D011948:Receptors, Antigen, T-Cell; D020395:Receptors, Interleukin-7