title: Serum S100B and neuron-specific enolase levels in normothermic and hypothermic infants after perinatal asphyxia.
abstract: OBJECTIVE
  Serum S100B and neuron-specific enolase (NSE) levels are elevated after perinatal asphyxia, but the influence of hypothermia on these proteins has not been previously reported. The aim of this study was to evaluate the effect of systemic hypothermia on these protein levels after perinatal asphyxia, time course, and association with perinatal factors and neurodevelopmental outcome at 2 years of age.
  
  
  METHODS
  Serum S100B and NSE levels were measured at fixed time points in asphyxiated infants treated with standard intensive care on hypothermia (HT: n = 13) or normothermia (NT: n = 11).
  
  
  RESULTS
  Serum S100B and NSE levels were grossly elevated in both HT and NT groups. Compared with the values at 6 h of age, S100B values decreased over time in both groups (NT: p = 0.002, HT: p = 0.04). Serum S100B values were lower in HT infants compared with those in NT infants (p = 0.047 at 48 h). Serum S100B and NSE values were significantly higher in infants who died or developed severe neurological impairment (S100B, p < 0.05 at all time points; NSE, p = 0.036 at 24 h of age).
  
  
  CONCLUSIONS
  Both NSE and S100B levels are highly elevated following asphyxia. Serum S100B levels were lower in the HT group and strongly correlated with the neurodevelopmental outcome.
authors: Neonatal Unit, Queen Charlotte's and Chelsea Hospital, London, UK. aniko.roka@gmail.com
authors: Aniko
authors: A
authors: Roka
authors: Dorottya
authors: D
authors: Kelen
authors: Jozsef
authors: J
authors: Halasz
authors: Gabriella
authors: G
authors: Beko
authors: Denis
authors: D
authors: Azzopardi
authors: Miklos
authors: M
authors: Szabo
mesh_terms: D001238:Asphyxia Neonatorum / Q000097:blood / Q000150:complications / Q000401:mortality / Q000628:therapy*; D015415:Biomarkers / Q000097:blood; D001831:Body Temperature; D001925:Brain Damage, Chronic / Q000175:diagnosis / Q000209:etiology; D002658:Developmental Disabilities / Q000175:diagnosis / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007036:Hypothermia, Induced; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009414:Nerve Growth Factors / Q000097:blood*; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human; D010751:Phosphopyruvate Hydratase