title: Renal parenchymal volume increases after contralateral nephrectomy: assessment using three-dimensional ultrasonography.
abstract: We investigated the relationship between changes in renal parenchymal volume (RPV) and renal function after a unilateral nephrectomy. In all 46 consecutive patients undergoing unilateral nephrectomy were included. Three-dimensional ultrasonography was performed before surgery (n=46) and at 4.3±1.9 h (n=46), 2 days (n=39), and 7 days (n=43) after surgery to determine RPV. The mean RPV of the remaining kidney was 104.7 mL before surgery, 116.1 mL (+13.2%) at 4.3 h, 122.7 mL (+18.2%) at 2 days, and 117.6 mL (+13.3%) at 7 days after surgery. Sequential volume measurements during surgery (n=5) revealed that the transection of the renal artery was followed by an increase in RPV on the contralateral side at 60-90 min. Multivariate regression analysis revealed that RPV was positively associated with the single-kidney glomerular filtration rate (GFR) and body surface area in both the preoperative and postoperative states. An increase in the single-kidney GFR was not seen at 2 years in patients with an RPV increase of <5% at 1 week (102.9±8.4%, P=0.322), but was still significant in the other patients (115.5±21.0%, P<0.001). These findings suggest that kidney volume may increase due to enlargement of the vascular bed caused by increased renal blood flow during the acute phase. Thereafter, histological hypertrophic responses may replace the hemodynamic changes in the chronic phase.
authors: Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan. funa418@yahoo.co.jp
authors: Yasuhito
authors: Y
authors: Funahashi
authors: Ryohei
authors: R
authors: Hattori
authors: Tokunori
authors: T
authors: Yamamoto
authors: Shigeyuki
authors: S
authors: Aoki
authors: Tsuyoshi
authors: T
authors: Majima
authors: Momokazu
authors: M
authors: Gotoh
mesh_terms: D000368:Aged; D001830:Body Surface Area; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D021621:Imaging, Three-Dimensional; D007668:Kidney / Q000033:anatomy & histology* / Q000000981:diagnostic imaging / Q000502:physiology; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009392:Nephrectomy; D009929:Organ Size; D014463:Ultrasonography
chemical_list: D003404:Creatinine