title: Synthesis and biological evaluation of antitumor-active arglabin derivatives.
abstract: Arglabin derivatives varied at the endo- or exo-cyclic double bond were synthesized and studied in a colorimetric sulforhodamine B assay for their cytotoxicity. Variations on the endocyclic double bond led to compounds of reduced cytotoxicity whereas derivatives from the reaction of the α-methylene-γ-butyrolactone moiety led to compounds of similar or only slightly reduced cytotoxicity but different, cell line-dependent selectivity. In addition, arglabin is an excellent starting material for the synthesis of the guaianolide arborescin.
authors: Martin-Luther-Universität Halle-Wittenberg, Bereich Organische Chemie, Halle (Saale), Germany. rene.csuk@chemie.uni-halle.de
authors: René
authors: R
authors: Csuk
authors: Anke
authors: A
authors: Heinold
authors: Bianka
authors: B
authors: Siewert
authors: Stefan
authors: S
authors: Schwarz
authors: Alexander
authors: A
authors: Barthel
authors: Ralph
authors: R
authors: Kluge
authors: Dieter
authors: D
authors: Ströhl
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003124:Colorimetry; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D012235:Rhodamines / Q000737:chemistry; D012717:Sesquiterpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045789:Sesquiterpenes, Guaiane; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D012235:Rhodamines; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane; C022027:lissamine rhodamine B; C083346:arglabin