title: Synthesis and apoptosis inducing ability of new anilino substituted pyrimidine sulfonamides as potential anticancer agents.
abstract: A series of anilino substituted pyrimidine sulfonamides were prepared and evaluated for their anticancer activity. These sulfonamides showed promising activity with IC(50) values ranging from 5.6 to 12.3 μM. The detailed biological aspects of some of the promising compounds (3d, 3e and 3g) on the K562 cell line were studied. Interestingly, compounds induced G1 cell cycle arrest and down regulation of G1 phase cell cycle regulatory proteins such as cyclin D1, CDK4. These compounds also exhibited inhibition of NF-κB as well as its downstream target gene Akt1 and the phosphorylated form of AKt ser 474 proteins. One of the representative compound 3e could be considered as the potential lead for its development as a new anticancer agent.
authors: Division of Organic Chemistry, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India. ahmedkamal@iict.res.in
authors: Ahmed
authors: A
authors: Kamal
authors: D
authors: D
authors: Dastagiri
authors: M Janaki
authors: MJ
authors: Ramaiah
authors: J Surendranadha
authors: JS
authors: Reddy
authors: E Vijaya
authors: EV
authors: Bharathi
authors: M Kashi
authors: MK
authors: Reddy
authors: M Victor Prem
authors: MV
authors: Sagar
authors: T Lakshminarayan
authors: TL
authors: Reddy
authors: S N C V L
authors: SN
authors: Pushpavalli
authors: Manika
authors: M
authors: Pal-Bhadra
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D019938:Cyclin D1 / Q000378:metabolism; D015536:Down-Regulation / Q000187:drug effects; D016193:G1 Phase / Q000187:drug effects; D006801:Humans; D016328:NF-kappa B / Q000235:genetics; D009369:Neoplasms / Q000188:drug therapy; D011743:Pyrimidines / Q000737:chemistry* / Q000494:pharmacology*; D013449:Sulfonamides / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D016328:NF-kappa B; D011743:Pyrimidines; D013449:Sulfonamides; D019938:Cyclin D1