title: Target recognition, resistance, immunity and genome mining of class II bacteriocins from Gram-positive bacteria.
abstract: Due to their very potent antimicrobial activity against diverse food-spoiling bacteria and pathogens and their favourable biochemical properties, peptide bacteriocins from Gram-positive bacteria have long been considered promising for applications in food preservation or medical treatment. To take advantage of bacteriocins in different applications, it is crucial to have detailed knowledge on the molecular mechanisms by which these peptides recognize and kill target cells, how producer cells protect themselves from their own bacteriocin (self-immunity) and how target cells may develop resistance. In this review we discuss some important recent progress in these areas for the non-lantibiotic (class II) bacteriocins. We also discuss some examples of how the current wealth of genome sequences provides an invaluable source in the search for novel class II bacteriocins.
authors: Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway.
authors: Morten
authors: M
authors: Kjos
authors: Departamento de Nutrición, Bromatología y Tecnología de los Alimentos, Facultad de Veterinaria, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain.
authors: Juan
authors: J
authors: Borrero
authors: Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway.
authors: Mona
authors: M
authors: Opsata
authors: Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway.
authors: Dagim J
authors: DJ
authors: Birri
authors: Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway.
authors: Helge
authors: H
authors: Holo
authors: Departamento de Nutrición, Bromatología y Tecnología de los Alimentos, Facultad de Veterinaria, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain.
authors: Luis M
authors: LM
authors: Cintas
authors: Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway.
authors: Lars
authors: L
authors: Snipen
authors: Departamento de Nutrición, Bromatología y Tecnología de los Alimentos, Facultad de Veterinaria, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain.
authors: Pablo E
authors: PE
authors: Hernández
authors: Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway.
authors: Ingolf F
authors: IF
authors: Nes
authors: Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway.
authors: Dzung B
authors: DB
authors: Diep
mesh_terms: D000900:Anti-Bacterial Agents / Q000378:metabolism*; D001430:Bacteriocins / Q000235:genetics* / Q000378:metabolism*; D019295:Computational Biology; D024881:Drug Resistance, Bacterial; D016680:Genome, Bacterial; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000235:genetics* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001430:Bacteriocins