title: Transformation of stimulus value signals into motor commands during simple choice.
abstract: Decision-making can be broken down into several component processes: assigning values to stimuli under consideration, selecting an option by comparing those values, and initiating motor responses to obtain the reward. Although much is known about the neural encoding of stimulus values and motor commands, little is known about the mechanisms through which stimulus values are compared, and the resulting decision is transmitted to motor systems. We investigated this process using human fMRI in a task where choices were indicated using the left or right hand. We found evidence consistent with the hypothesis that value signals are computed in the ventral medial prefrontal cortex, they are passed to regions of dorsomedial prefrontal cortex and intraparietal sulcus, implementing a comparison process, and the output of the comparator regions modulates activity in motor cortex to implement the choice. These results describe the network through which stimulus values are transformed into actions during a simple choice task.
authors: Computation and Neural Systems Division, California Institute of Technology, Pasadena, CA 91125, USA. todd.hare@econ.uzh.ch
authors: Todd A
authors: TA
authors: Hare
authors: Wolfram
authors: W
authors: Schultz
authors: Colin F
authors: CF
authors: Camerer
authors: John P
authors: JP
authors: O'Doherty
authors: Antonio
authors: A
authors: Rangel
mesh_terms: D000328:Adult; D003657:Decision Making; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011594:Psychometrics; D013647:Task Performance and Analysis