title: Mechanisms and principles of N-linked protein glycosylation.
abstract: N-linked glycosylation, a protein modification system present in all domains of life, is characterized by a high structural diversity of N-linked glycans found among different species and by a large number of proteins that are glycosylated. Based on structural, functional, and phylogenetic approaches, this review discusses the highly conserved processes that are at the basis of this unique general protein modification system.
authors: Institute of Microbiology, Department of Biology, ETH Zurich, 8093 Zurich, Switzerland.
authors: Flavio
authors: F
authors: Schwarz
authors: Markus
authors: M
authors: Aebi
mesh_terms: D001105:Archaea / Q000378:metabolism; D001216:Asparagine / Q000378:metabolism*; D001419:Bacteria / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D016384:Consensus Sequence; D003600:Cytosol / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D004789:Enzyme Activation; D006031:Glycosylation; D006602:Hexosyltransferases / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D010802:Phylogeny; D011134:Polysaccharides / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D013379:Substrate Specificity
chemical_list: D008565:Membrane Proteins; D011134:Polysaccharides; D001216:Asparagine; D006602:Hexosyltransferases; C025620:dolichyl-diphosphooligosaccharide - protein glycotransferase