title: Motor and non-motor behaviour in experimental Huntington's disease.
abstract: In this study, we investigated motor and non-motor behaviour in the transgenic rat model of Huntington's disease (tgHD). In particular, we were interested in the development and changes of motor and non-motor features (anxiety, motivation and hedonia) of disease over time and their interactions. We found tgHD animals to be hyperkinetic in the open field test compared to their wild-type littermates at all ages tested, which was accompanied by reduced anxiety-like behaviour in the open field test and the elevated zero maze, but not in the home cage emergence test. No major changes were found in hedonia (sucrose intake test) and motivation for food (food intake test). Our data suggest that hyperkinetic features and reduced-anxiety in the tgHD rats are associated behaviours and are seen in the earlier stages of the disease.
authors: Department of Neuroscience, Maastricht University Medical School, Maastricht, The Netherlands. dh.zeef@maastrichtuniversity.nl
authors: Dagmar H
authors: DH
authors: Zeef
authors: Rinske
authors: R
authors: Vlamings
authors: Lee Wei
authors: LW
authors: Lim
authors: Sonny
authors: S
authors: Tan
authors: Marcus L F
authors: ML
authors: Janssen
authors: Ali
authors: A
authors: Jahanshahi
authors: Govert
authors: G
authors: Hoogland
authors: Jos
authors: J
authors: Prickaerts
authors: Harry W M
authors: HW
authors: Steinbusch
authors: Yasin
authors: Y
authors: Temel
mesh_terms: D000367:Age Factors; D000818:Animals; D030801:Animals, Genetically Modified; D001007:Anxiety / Q000150:complications / Q000235:genetics / Q000503:physiopathology / Q000523:psychology; D004195:Disease Models, Animal; D004435:Eating / Q000235:genetics / Q000502:physiology*; D005106:Exploratory Behavior / Q000502:physiology*; D006801:Humans; D006816:Huntington Disease / Q000150:complications / Q000235:genetics / Q000503:physiopathology* / Q000523:psychology*; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D009042:Motivation / Q000235:genetics / Q000502:physiology; D051381:Rats