title: 9,10-secosteroids, protein kinase inhibitors from the Chinese gorgonian Astrogorgia sp.
abstract: Fourteen new 9,10-secosteroids designated as astrogorgols A-N (1-14) were isolated from a Chinese gorgonian Astrogorgia sp. together with eight known analogues. The structural patterns were characterized by the presence of a sterol-based 9,10-seco nucleus containing a 3-hydroxy-10-methylphenyl ring. Astrogorgol N (14) possessing a 1,4-dien-3-one unit in ring A was biogenetically considered as an intermediate to generate diverse 9,10-secosteroids. Five compounds showed significant inhibitory activities against human tumor related protein kinases, including ALK, AXL, FAK, IGF-1R, MET wt, SRC, and VEGF-R2.
authors: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, PR China.
authors: Daowan
authors: D
authors: Lai
authors: Shanjiang
authors: S
authors: Yu
authors: Leen
authors: L
authors: van Ofwegen
authors: Frank
authors: F
authors: Totzke
authors: Peter
authors: P
authors: Proksch
authors: Wenhan
authors: W
authors: Lin
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D047428:Protein Kinase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D012632:Secosteroids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D047428:Protein Kinase Inhibitors; D012632:Secosteroids