title: Semen quality in patients with Chlamydia trachomatis genital infection treated concurrently with prulifloxacin and a phytotherapeutic agent.
abstract: Chronic prostatitis (CP) due to Chlamydia trachomatis (Ct) infection has a significant impact on young male fertility, and eradication of Ct infection after antibiotic therapy does not always result in recovery of semen quality. The study aim was to evaluate the effects on fertility parameters of L-arginine, L-carnitine, acetyl-L-carnitine, and ginseng extracts (FERTIMEV) associated with prulifloxacin in patients affected by CP and oligoasthenoteratozoospermia due to Ct infection. Two hundred and six patients with proven Ct genital infection and oligoasthenoteratozoospermia were enrolled in a prospective, randomized, and controlled study. Prulifloxacin (600 mg) was administered daily for 14 days, and patients were divided into 2 groups: group A: antibiotic therapy alone; and group B: antibiotic therapy and additional therapy with FERTIMEV (1 vial daily for 6 months). Microbiological and semen parameter analyses were performed both at enrollment and after 6 months. National Institutes of Health Chronic Prostatitis Symptom Index and International Prostatic Symptom Score questionnaires were applied. Of the 206 patients, 109 were assigned to group A and 97 to group B. At the enrollment time, no differences were reported with regard to clinical, instrumental, and laboratory data. Six months after treatment, statistically significant differences were demonstrated between both groups in terms of sperm concentration (21.3 ± 13.2 millions/mL vs 11.5 ± 13.2 millions/mL) (Cohen's d = 0.61) (P < .001, df = 2, F = 62.10) and percentage of motile sperm (42.4% ± 5.2% vs 29.3% ± 11.0%) (Cohen's d = 1.52) (P < .001, df = 2, F = 91.48). In this study treatment with FERTIMEV together with prulifloxacin improved semen parameters in patients with Ct genital infection and oligoasthenoteratozoospermia compared to treatment with prulifloxacin therapy alone.
authors: Department of Urology, Santa Chiara Hospital, Largo Medaglie d'Oro 9, Trento, Italy. ktommy@libero.it
authors: Tommaso
authors: T
authors: Cai
authors: Florian M E
authors: FM
authors: Wagenlehner
authors: Sandra
authors: S
authors: Mazzoli
authors: Francesca
authors: F
authors: Meacci
authors: Nicola
authors: N
authors: Mondaini
authors: Gabriella
authors: G
authors: Nesi
authors: Daniele
authors: D
authors: Tiscione
authors: Gianni
authors: G
authors: Malossini
authors: Riccardo
authors: R
authors: Bartoletti
mesh_terms: D000108:Acetylcarnitine / Q000008:administration & dosage; D000328:Adult; D001120:Arginine / Q000008:administration & dosage; D053627:Asthenozoospermia / Q000188:drug therapy*; D002331:Carnitine / Q000008:administration & dosage; D002690:Chlamydia Infections / Q000188:drug therapy*; D002692:Chlamydia trachomatis; D004148:Dioxolanes / Q000008:administration & dosage*; D024841:Fluoroquinolones / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000188:drug therapy*; D005894:Panax / Q000737:chemistry*; D010879:Piperazines / Q000008:administration & dosage*; D010936:Plant Extracts / Q000008:administration & dosage*; D011472:Prostatitis / Q000188:drug therapy*; D055101:Semen Analysis
chemical_list: D004148:Dioxolanes; D024841:Fluoroquinolones; D010879:Piperazines; D010936:Plant Extracts; D000108:Acetylcarnitine; D001120:Arginine; C074191:prulifloxacin; D002331:Carnitine