title: Myocardial tissue Doppler velocities in fetuses with hypoplastic left heart syndrome.
abstract: BACKGROUND
  Tissue Doppler Imaging (TDI) is a sensitive index of myocardial function. Its role in the fetus has not been extensively evaluated.
  
  
  OBJECTIVE
  To compare myocardial tissue Doppler velocities in fetuses with hypoplastic left heart syndrome (HLHS) to those of normal fetuses (matched for gestational age.)
  
  
  METHODS
  Cross-sectional retrospective study conducted at 2 large perinatal centers (2003-2007). Fetuses with HLHS (n = 13) were compared with normal fetuses (n = 207) in 5 gestational age groups. TDI data included peak systolic (s'), peak early (e'), and late diastolic velocities (a'). Linear regression was used to compare TDI parameters in fetuses with HLHS to normal fetuses matched for gestational age.
  
  
  RESULTS
  Fetuses with HLHS had significantly reduced lateral tricuspid annular e' as compared to normal fetuses. Both normal fetuses and those with HLHS had linear increase in TDI velocities with advancing gestational age.
  
  
  CONCLUSIONS
  TDI velocities are abnormal in fetuses with HLHS. TDI can be useful in serial follow-up of cardiac function in fetuses with HLHS.
authors: Department of Pediatrics, Division of Pediatric Cardiology, Mayo Clinic College of Medicine, Rochester, MN, USA.
authors: Himesh V
authors: HV
authors: Vyas
authors: Benjamin W
authors: BW
authors: Eidem
authors: Frank
authors: F
authors: Cetta
authors: Ganesh
authors: G
authors: Acharya
authors: James
authors: J
authors: Huhta
authors: David
authors: D
authors: Roberson
authors: Bettina
authors: B
authors: Cuneo