title: Functionalization of DNA nanostructures with proteins.
abstract: Proteins possess intrinsic functionalities, which have been optimized in billions of years of natural evolution. The conjugation of proteins with artificial nucleic acids allows one to further functionalize proteins with a synthetically accessible, physicochemically robust tag, which is addressable in a highly specific manner by Watson-Crick hybridization. The resulting DNA-protein conjugates can be advantageously used in a variety of applications, ranging from biomedical diagnostics to DNA-based nanofabrication. This critical review provides an overview on chemical approaches to the synthesis of DNA-protein conjugates and their applications in biomolecular nanosciences (96 references).
authors: Technische Universität Dortmund, Fakultät Chemie, Biologisch-Chemische Mikrostrukturtechnik, Dortmund, Germany.
authors: Barbara
authors: B
authors: Saccà
authors: Christof M
authors: CM
authors: Niemeyer
mesh_terms: D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D049329:Nanostructures; D036103:Nanotechnology / Q000379:methods*; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D011506:Proteins; D004247:DNA