title: [The relationship between anaphylatoxin C3a and benign prostatic hyperplasia with inflammation].
abstract: OBJECTIVE
  To study the relationship of anaphylatoxin C3a level in expressed prostatic secretions (EPS) with prostate tissue inflammation in BPH.
  
  
  METHODS
  This study included 40 BPH patients receiving TURP operational therapy in West China Hospital during September, 2009 to March, 2010. For each patient, IPSS and NIH-CPSI were evaluated, serum PSA levels, prostatic volume and urine WBC were measured. EPS was collected before operation for the test of C3a level, while EPS also was obtained from 10 healthy men as normal control. Prostatic tissue was collected by the operation and histological inflammation was investigated by histopathological study.
  
  
  RESULTS
  C3a levels in EPS of the BPH patients: severe inflammation group > mild inflammation group > normal control group (all P < 0.01). C3a levels in the EPS could be used to determine whether BPH combined inflammation, sensitivity : 0.97, specificity: 0.70. C3a levels in EPS was not relevant with PSA, fPSA levels, age, BMI, prostate volume or urine WBC levels; but NIH-CPSI was correlated (r = 0.495, P < 0.01). C3a in EPS of retained catheter group was more than non-catheter group significantly (P < 0.05).
  
  
  CONCLUSIONS
  C3a is an ideal criteria to diagnose prostatic histological inflammation in BPH patients. There is no convincing evidence to correlate C3a in EPS with serum PSA levels, BMI, age, prostatic volume and urine's WBC. Excessively high C3a levels and the NIH-CPSI, indwelling have correlations.
authors: Department of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.
authors: Liang
authors: L
authors: Xie
authors: Shu-Lin
authors: SL
authors: Cheng
authors: Yi-Zhu
authors: YZ
authors: Li
authors: Liang-Ren
authors: LR
authors: Liu
authors: Ping
authors: P
authors: Han
authors: Ni
authors: N
authors: Chen
authors: Qiang
authors: Q
authors: Wei
authors: Qiao
authors: Q
authors: Zhou
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003176:Complement C3 / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D011472:Prostatitis / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism*
chemical_list: C038245:C3 protein, human; D003176:Complement C3