title: Potential pharmacological applications of polyphenolic derivatives from marine brown algae.
abstract: Recently, the isolation and characterization of the biologically active components from seaweeds have gained much attention from various research groups across the world. The marine algae have been studied for biologically active components and phlorotannins are one among them. Among marine algae, brown algal species such as Ecklonia cava, Eisenia arborea, Ecklonia stolinifera and Eisenia bicyclis have been studied for their potential biological activities. Majority of the investigations on phlorotannins derived from brown algae have exhibited their potentiality as antioxidant, anti-inflammatory, antidiabetic, antitumor, antihypertensive, anti-allergic, hyaluronidase enzyme inhibition and in matrix metalloproteinases (MMPs) inhibition activity. In this review, we have made an attempt to discuss the potential biological activities of phlorotannins from marine brown algae and their possible candidature in the pharmaceutical applications.
authors: Marine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan 608-737, Republic of Korea.
authors: Noel Vinay
authors: NV
authors: Thomas
authors: Se-Kwon
authors: SK
authors: Kim
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology; D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000037:antagonists & inhibitors; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology; D061965:Matrix Metalloproteinase Inhibitors; D000459:Phaeophyceae / Q000737:chemistry*; D059808:Polyphenols / Q000737:chemistry* / Q000494:pharmacology*; D012624:Seaweed / Q000737:chemistry; D013634:Tannins / Q000737:chemistry / Q000494:pharmacology
chemical_list: D018926:Anti-Allergic Agents; D019380:Anti-HIV Agents; D000893:Anti-Inflammatory Agents; D000959:Antihypertensive Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D004791:Enzyme Inhibitors; D007004:Hypoglycemic Agents; D061965:Matrix Metalloproteinase Inhibitors; D059808:Polyphenols; D013634:Tannins; D006821:Hyaluronoglucosaminidase