title: Accumulation of visceral fat in maintenance hemodialysis patients.
abstract: BACKGROUND
  In hemodialysis (HD) patients, obesity has been recognized as a serious risk factor for mortality and morbidity for cardiovascular diseases. In addition, abnormalities of lipid profiles exist in these patients.
  
  
  METHODS
  In patients undergoing maintenance HD, incidences of abnormality of lipid profiles and visceral obesity determined by computed tomography scans were compared. In addition, the relationship between visceral fat area (VFA) and brachial-ankle pulse wave velocity (baPWV), an index of arterial stiffness, or carotid intima-media thickness (IMT), an index of atherosis, was examined.
  
  
  RESULTS
  The incidence of high VFA (27.0%) was significantly greater than that of high body mass index (BMI) (9.7%), high low-density-lipoprotein cholesterol (LDL-C) (4.8%), and high triglyceride (12.7%). In patients with diabetes mellitus (DM), waist circumference and VFA showed a significant positive relationship with baPWV. baPWV was significantly higher in patients with high VFA and DM than in patients with low VFA without DM, those with high VFA without DM, and those with low VFA and DM. Carotid IMT was significantly greater in patients with high VFA and DM than in those with low VFA without DM and those with low VFA and DM.
  
  
  CONCLUSIONS
  The incidence of high VFA was much greater than that of high BMI, high LDL-C, or high triglyceride. Visceral fat accumulation may be related to both arterial stiffness and atherosis in diabetic patients on maintenance HD.
authors: Second Department of Internal Medicine, Kansai Medical University, 2-3-1 Shin-machi, Hirakata, Osaka, 573-1191, Japan. yurugitakatomi@yahoo.co.jp
authors: Takatomi
authors: T
authors: Yurugi
authors: Satoshi
authors: S
authors: Morimoto
authors: Takayuki
authors: T
authors: Okamoto
authors: Yoshifumi
authors: Y
authors: Amari
authors: Yuko
authors: Y
authors: Kasuno
authors: Masayoshi
authors: M
authors: Fukui
authors: Fumitaka
authors: F
authors: Nakajima
authors: Mitsushige
authors: M
authors: Nishikawa
authors: Toshiji
authors: T
authors: Iwasaka
mesh_terms: D055109:Ankle Brachial Index; D001783:Blood Flow Velocity; D015992:Body Mass Index; D059168:Carotid Intima-Media Thickness; D008078:Cholesterol, LDL / Q000097:blood; D003920:Diabetes Mellitus / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging*; D009765:Obesity / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011673:Pulsatile Flow; D006435:Renal Dialysis / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed; D014280:Triglycerides / Q000097:blood; D059289:Vascular Stiffness; D055105:Waist Circumference
chemical_list: D008078:Cholesterol, LDL; D014280:Triglycerides