title: Ebola virus failure to stimulate plasmacytoid dendritic cell interferon responses correlates with impaired cellular entry.
abstract: We examined the ability of the Ebola virus to elicit an antiviral response from plasmacytoid dendritic cells (pDCs). Exposure of pDCs to Ebola virus did not result in significantly higher levels of interferon-α production than the levels in mock-infected cells. After inoculation with Ebola virus under the same conditions, conventional dendritic cells expressed viral proteins whereas pDCs did not, suggesting that the latter cells were not infected. Assessment of the entry of Ebola virus-like particles into pDCs revealed that pDCs are highly impaired for viral entry in comparison with conventional dendritic cells. These observations identify a novel means by which Ebola virus can avoid triggering an antiviral response.
authors: Department of Microbiology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York 10029, USA.
authors: Lawrence W
authors: LW
authors: Leung
authors: Osvaldo
authors: O
authors: Martinez
authors: Olivier
authors: O
authors: Reynard
authors: Viktor E
authors: VE
authors: Volchkov
authors: Christopher F
authors: CF
authors: Basler
mesh_terms: D003713:Dendritic Cells / Q000276:immunology* / Q000821:virology*; D029043:Ebolavirus / Q000502:physiology*; D015967:Gene Expression Regulation, Viral / Q000502:physiology; D006801:Humans; D007372:Interferons / Q000378:metabolism*; D014764:Viral Proteins / Q000378:metabolism; D053586:Virus Internalization
chemical_list: D014764:Viral Proteins; D007372:Interferons