title: PHGDH amplification and altered glucose metabolism in human melanoma.
abstract: The metabolic requirements of cancer cells differ from that of their normal counterparts. To support their proliferation, cancer cells switch to a fermentative metabolism that is thought to support biomass production. Instances where metabolic enzymes promote tumorigenesis remain rare. However, an enzyme involved in the de novo synthesis of serine, 3-phosphoglycerate dehydrogenase (PHGDH), was recently identified as a putative oncogene. The potential mechanisms by which PHGDH promotes cancer are discussed.
authors: Division of Signal Transduction, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
authors: Edouard
authors: E
authors: Mullarky
authors: Katherine R
authors: KR
authors: Mattaini
authors: Matthew G
authors: MG
authors: Vander Heiden
authors: Lewis C
authors: LC
authors: Cantley
authors: Jason W
authors: JW
authors: Locasale
mesh_terms: D005784:Gene Amplification; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008545:Melanoma / Q000201:enzymology* / Q000235:genetics*; D053858:Metabolic Networks and Pathways; D050543:Phosphoglycerate Dehydrogenase / Q000235:genetics*; D012878:Skin Neoplasms / Q000201:enzymology* / Q000235:genetics*
chemical_list: D050543:Phosphoglycerate Dehydrogenase; D005947:Glucose