title: Endothelin(A)-endothelin(B) receptor cross-talk and endothelin receptor binding.
abstract: OBJECTIVE
  The magnitude of inhibition of an endothelin (ET)-1 response by selective blockade of the ET(A) or ET(B) receptors can be limited by apparent compensation mediated by the unblocked receptor. While the mechanism underlying this functionally defined interaction, or 'cross-talk', is not clear, binding studies suggest an interaction between the ET receptor subtypes.
  
  
  RESULTS
  These binding studies are reviewed and suggest that, in general, they support the hypothesis that ET(A) and ET(B) receptor activation of intracellular signalling pathways influence ET-1 binding to these receptor subtypes.
  
  
  CONCLUSIONS
  However, the relationship of these binding studies to functional effects and, thus, functional ET(A)-ET(B) receptor cross-talk, remains largely untested.
authors: Research Service, Veterans Affairs Medical Center, Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0575, USA. robert.rapoport@uc.edu
authors: Robert M
authors: RM
authors: Rapoport
authors: Mario
authors: M
authors: Zuccarello
mesh_terms: D000818:Animals; D065130:Endothelin A Receptor Antagonists; D065131:Endothelin B Receptor Antagonists; D019332:Endothelin-1 / Q000378:metabolism; D006801:Humans; D020239:Receptor Cross-Talk / Q000502:physiology*; D044022:Receptor, Endothelin A / Q000378:metabolism*; D044023:Receptor, Endothelin B / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D065130:Endothelin A Receptor Antagonists; D065131:Endothelin B Receptor Antagonists; D019332:Endothelin-1; D044022:Receptor, Endothelin A; D044023:Receptor, Endothelin B