title: A case of pure red cell aplasia and immune thrombocytopenia complicating systemic lupus erythematosus: response to rituximab and cyclophosphamide.
abstract: Pure red cell aplasia (PRCA) is a recognized but rare complication of systemic lupus erythematosus (SLE) and is characterized by the near absence of red blood cell precursors in the bone marrow but with normal megakaryocyte and granulocytes. We report a novel case of acquired PRCA occurring simultaneously with immune thrombocytopenia in the context of active SLE. Both syndromes were refractory to conventional treatment but responded to rituximab and cyclophosphamide.
authors: Department of Rheumatology, University College Hospital, London, UK.
authors: R K
authors: RK
authors: Gupta
authors: A N
authors: AN
authors: Ezeonyeji
authors: A S
authors: AS
authors: Thomas
authors: M A
authors: MA
authors: Scully
authors: M R
authors: MR
authors: Ehrenstein
authors: D A
authors: DA
authors: Isenberg
mesh_terms: D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy; D012010:Red-Cell Aplasia, Pure / Q000188:drug therapy / Q000209:etiology*; D000069283:Rituximab; D013921:Thrombocytopenia / Q000188:drug therapy / Q000276:immunology*; D055815:Young Adult
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D018501:Antirheumatic Agents; D005938:Glucocorticoids; D000069283:Rituximab; D003520:Cyclophosphamide