title: Donor specific antibodies after transplantation.
abstract: The detection of donor-specific antibodies after organ transplantation might provide an incisive way to monitor allo-specific immunity and predict graft outcome. Still, the availability of new assays for these antibodies prompts us to pose some questions about results that might be observed. These questions include whether the antibodies detected in the blood are a sensitive measure of alloimmunity, whether the detected antibodies are truly specific for the donor and whether they are noxious for the graft. Here, we explain why answers to these questions might interest the basic scientist and clinician.
authors: Department of Surgery, University of Michigan, Ann Arbor, MI 48109-2200, USA. plattjl@umich.edu
authors: Jeffrey L
authors: JL
authors: Platt
authors: Marilia
authors: M
authors: Cascalho
mesh_terms: D000818:Animals; D000906:Antibodies / Q000737:chemistry*; D006084:Graft Rejection / Q000276:immunology; D006085:Graft Survival / Q000276:immunology; D006650:Histocompatibility Testing / Q000379:methods; D006801:Humans; D007107:Immune System; D056724:Immunity, Humoral; D007249:Inflammation; D007518:Isoantibodies / Q000737:chemistry; D016030:Kidney Transplantation / Q000379:methods; D010372:Pediatrics / Q000379:methods*; D010477:Perfusion; D010641:Phenotype; D014180:Transplantation / Q000379:methods*; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous / Q000379:methods
chemical_list: D000906:Antibodies; D007518:Isoantibodies