title: Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in T(H)17 cells.
abstract: Interleukin 22 (IL-22), which is produced by cells of the T(H)17 subset of helper T cells and other leukocytes, not only enhances proinflammatory innate defense mechanisms in epithelial cells but also provides crucial protection to tissues from damage caused by inflammation and infection. In T(H)17 cells, transforming growth factor-β (TGF-β) regulates IL-22 and IL-17 differently. IL-6 alone induces T cells to produce only IL-22, whereas the combination of IL-6 and high concentrations of TGF-β results in the production of IL-17 but not IL-22 by T cells. Here we identify the transcription factor c-Maf, which is induced by TGF-β, as a downstream repressor of Il22. We found that c-Maf bound to the Il22 promoter and was both necessary and sufficient for the TGF-β-dependent suppression of IL-22 production in T(H)17 cells.
authors: Department of Immunology, Genentech, South San Francisco, California, USA.
authors: Sascha
authors: S
authors: Rutz
authors: Rajkumar
authors: R
authors: Noubade
authors: Céline
authors: C
authors: Eidenschenk
authors: Naruhisa
authors: N
authors: Ota
authors: Wenwen
authors: W
authors: Zeng
authors: Yan
authors: Y
authors: Zheng
authors: Jason
authors: J
authors: Hackney
authors: Jiabing
authors: J
authors: Ding
authors: Harinder
authors: H
authors: Singh
authors: Wenjun
authors: W
authors: Ouyang
mesh_terms: D000818:Animals; D001483:Base Sequence; D050976:Basic-Leucine Zipper Transcription Factors / Q000235:genetics / Q000378:metabolism; D001665:Binding Sites / Q000235:genetics; D002478:Cells, Cultured; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000187:drug effects; D057809:HEK293 Cells; D006801:Humans; D007378:Interleukins / Q000096:biosynthesis* / Q000235:genetics; D051379:Mice; D008807:Mice, Inbred BALB C; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000235:genetics / Q000378:metabolism; D059372:Nucleotide Motifs; D011401:Promoter Regions, Genetic; D051257:Proto-Oncogene Proteins c-maf / Q000235:genetics / Q000378:metabolism*; D018336:Receptors, Aryl Hydrocarbon / Q000235:genetics / Q000378:metabolism; D058504:Th17 Cells / Q000187:drug effects / Q000276:immunology*; D014158:Transcription, Genetic; D016212:Transforming Growth Factor beta / Q000494:pharmacology*; D000097043:Interleukin-22
chemical_list: D050976:Basic-Leucine Zipper Transcription Factors; D007378:Interleukins; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D051257:Proto-Oncogene Proteins c-maf; D018336:Receptors, Aryl Hydrocarbon; D016212:Transforming Growth Factor beta; D000097043:Interleukin-22; C431772:Batf protein, mouse