title: Anatomical study of serotonergic innervation and 5-HT(1A) receptor in the human spinal cord.
abstract: Serotonergic innervation of the spinal cord in mammals has multiple roles in the control of motor, sensory and visceral functions. In rats, functional consequences of spinal cord injury at thoracic level can be improved by a substitutive transplantation of serotonin (5-HT) neurons or regeneration under the trophic influence of grafted stem cells. Translation to either pharmacological and/or cellular therapies in humans requires the mapping of the spinal cord 5-HT innervation and its receptors to determine their involvement in specific functions. Here, we have performed a preliminary mapping of serotonergic processes and serotonin-lA (5-HT(1A)) receptors in thoracic and lumbar segments of the human spinal cord. As in rodents and non-human primates, 5-HT profiles in human spinal cord are present in the ventral horn, surrounding motoneurons, and also contact their presumptive dendrites at lumbar level. 5-HT(1A) receptors are present in the same area, but are more densely expressed at lumbar level. 5-HT profiles are also present in the intermediolateral region, where 5-HT(1A) receptors are absent. Finally, we observed numerous serotonergic profiles in the superficial part (equivalent of Rexed lamina II) of the dorsal horn, which also displayed high levels of 5-HT(1A) receptors. These findings pave the way for local specific therapies involving cellular and/or pharmacological tools targeting the serotonergic system.
authors: IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.
authors: F E
authors: FE
authors: Perrin
authors: Y N
authors: YN
authors: Gerber
authors: M
authors: M
authors: Teigell
authors: N
authors: N
authors: Lonjon
authors: G
authors: G
authors: Boniface
authors: L
authors: L
authors: Bauchet
authors: J J
authors: JJ
authors: Rodriguez
authors: J P
authors: JP
authors: Hugnot
authors: A M
authors: AM
authors: Privat
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D051381:Rats; D044282:Receptor, Serotonin, 5-HT1A / Q000378:metabolism*; D059326:Serotonergic Neurons / Q000166:cytology* / Q000378:metabolism; D013116:Spinal Cord / Q000033:anatomy & histology* / Q000378:metabolism; D055815:Young Adult
chemical_list: D044282:Receptor, Serotonin, 5-HT1A