title: Plasma concentrations of interleukin-6, C-reactive protein, tumor necrosis factor-α and matrix metalloproteinase-9 in aortic dissection.
abstract: BACKGROUND
  The role of inflammation in aortic dissection (AD) has not fully been investigated. We evaluated the potential relationships between interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and matrix metalloproteinase-9 (MMP-9) and AD.
  
  
  METHODS
  Plasma concentrations of IL-6, TNF-α, MMP-9 and CRP were determined in 64 acute AD patients, 42 patients with chronic AD, 98 patients with hypertension alone, and 96 healthy subjects.
  
  
  RESULTS
  IL-6 concentrations were higher in acute AD than that in hypertension and healthy controls (10.98±2.38 vs. 3.79±1.56 and 3.32±1.60 pg/ml, P<0.05, respectively). Increased CRP concentrations were found in acute AD compared with chronic AD and hypertension as well as healthy subjects (13.48±3.74 vs. 4.12±2.99, 1.62±0.65 and 1.12±0.35 mg/l, P<0.001, respectively). Higher MMP-9 concentrations were detected in acute AD, chronic AD and hypertension compared with healthy controls (37.75±9.38, 55.78±6.41 and 31.03±7.94 vs. 21.24±7.28 ng/ml, P<0.05, P<0.001 and P<0.05, respectively), and in the dead compared to the survived (107.29±9.38 vs. 86.80±7.93 ng/ml, P<0.001) among acute AD patients. In acute AD, the time after onset had positive correlation with TNF-α (r=0.497, P=0.000), and negative correlation with CRP (r=-0.424, P=0.000). Plasma CRP levels decreased significantly when the onset time increased (P=0.013). Moreover, in the patients with acute AD who underwent surgery and stenting, plasma MMP-9 concentrations increased immediately after surgical treatment and stenting, and reached the peak values at 24h, then decreased at 1 week (P<0.001).
  
  
  CONCLUSIONS
  Our findings confirmed and extended previous studies that increased plasma inflammatory markers were significantly associated with AD.
authors: Department of Cardiology, Fu Wai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors: Dan
authors: D
authors: Wen
authors: Xian-Liang
authors: XL
authors: Zhou
authors: Jian-Jun
authors: JJ
authors: Li
authors: Fang
authors: F
authors: Luo
authors: Lin
authors: L
authors: Zhang
authors: Ling-Gen
authors: LG
authors: Gao
authors: Lin-Ping
authors: LP
authors: Wang
authors: Lei
authors: L
authors: Song
authors: Kai
authors: K
authors: Sun
authors: Yu-Bao
authors: YB
authors: Zou
authors: Chan-Na
authors: CN
authors: Zhang
authors: Ru-Tai
authors: RT
authors: Hui
mesh_terms: D000784:Aortic Dissection / Q000097:blood*; D001014:Aortic Aneurysm / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein; D020780:Matrix Metalloproteinase 9