title: The effect of Plantago major Linnaeus on serum total sialic acid, lipid-bound sialic acid, some trace elements and minerals after administration of 7,12-dimethylbenz(a)anthracene in rats.
abstract: The present study was designed to evaluate the effect of Plantago major Linnaeus (PM) extract on serum total sialic acid (TSA), lipid-bound sialic acid (LSA), some trace elements (copper (Cu), zinc (Zn) and iron) and mineral levels (magnesium, calcium and sodium) in Wistar albino rat administrated 7,12-dimethylbenz(a)anthracene (DMBA). Rats were divided into three equal groups (n = 6). Group I comprised the control group, group II was treated with DMBA (100 mg/kg, single dose) and group III was treated with DMBA (100 mg/kg single dose) and aqueous extract of PM 100 mg/kg/day for 60 days. After 60 days, statistical analyses showed that TSA and LSA levels in DMBA and DMBA + PM groups were significantly higher compared to the control group (TSA: p < 0.01, p < 0.05; LSA: p < 0.05, p < 0.05, respectively). Serum Zn levels were decreased in subjects treated with DMBA (p < 0.01) and DMBA + PM (p < 0.05) compared to the control group values. Serum Cu levels were increased in DMBA group and PM-treated group compared to the control group values. The results of this investigation showed that the levels of TSA and LSA changed significantly, which are sensitive markers for detecting the toxic effects of DMBA. On the other hand, observed decline in Zn levels in rats from DMBA + PM group might be due to decreased generation of free radicals and oxidative stress. Results from this study suggest that PM may be partially effective in preventing carcinogenesis initiated by environmental carcinogen DMBA.
authors: Department of Pharmacology, Medical Faculty, Yuzuncu Yil University, Van, Turkey. gokhanoto@hotmail.com
authors: Gokhan
authors: G
authors: Oto
authors: Suat
authors: S
authors: Ekin
authors: Hulya
authors: H
authors: Ozdemir
authors: Abdulkadir
authors: A
authors: Levent
authors: Ismet
authors: I
authors: Berber
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity*; D000704:Analysis of Variance; D000818:Animals; D008670:Metals / Q000097:blood; D008903:Minerals / Q000097:blood*; D019158:N-Acetylneuraminic Acid / Q000097:blood*; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D010943:Plantago / Q000737:chemistry*; D020011:Protective Agents / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014131:Trace Elements / Q000097:blood*
chemical_list: D008670:Metals; D008903:Minerals; D010936:Plant Extracts; D020011:Protective Agents; D014131:Trace Elements; D015127:9,10-Dimethyl-1,2-benzanthracene; D019158:N-Acetylneuraminic Acid