title: Rabs and EHDs: alternate modes for traffic control.
abstract: Endocytic trafficking is a highly organized process regulated by a network of proteins, including the Rab family of small GTP-binding proteins and the C-terminal EHDs (Eps15 homology-domain-containing proteins). Central roles for Rab proteins have been described in vesicle budding, delivery, tethering and fusion, whereas little is known about the functions of EHDs in membrane transport. Common effectors for these two protein families have been identified, and they facilitate regulation of sequential steps in transport. By comparing and contrasting key aspects in their modes of function, we shall promote a better understanding of how Rab proteins and EHDs regulate endocytic trafficking.
authors: Department of Biochemistry and Molecular Biology and Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA.
authors: Jing
authors: J
authors: Zhang
authors: Naava
authors: N
authors: Naslavsky
authors: Steve
authors: S
authors: Caplan
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology*; D006801:Humans; D060066:Protein Interaction Maps; D021381:Protein Transport; D033921:Vesicular Transport Proteins / Q000378:metabolism*; D020691:rab GTP-Binding Proteins / Q000502:physiology*
chemical_list: D002352:Carrier Proteins; C120700:EHD1 protein, human; C406446:EHD2 protein, human; D033921:Vesicular Transport Proteins; D020691:rab GTP-Binding Proteins