title: An artificial metalloenzyme for olefin metathesis.
abstract: A Grubbs-Hoveyda type olefin metathesis catalyst, equipped with an electrophilic bromoacetamide group, was used to modify a cysteine-containing variant of a small heat shock protein from Methanocaldococcus jannaschii. The resulting artificial metalloenzyme was found to be active under acidic conditions in a benchmark ring closing metathesis reaction.
authors: Laboratory of Organic Chemistry, ETH Zürich, 8093 Zürich, Switzerland.
authors: Clemens
authors: C
authors: Mayer
authors: Dennis G
authors: DG
authors: Gillingham
authors: Thomas R
authors: TR
authors: Ward
authors: Donald
authors: D
authors: Hilvert
mesh_terms: D000498:Allyl Compounds / Q000737:chemistry; D019843:Archaeal Proteins / Q000737:chemistry*; D002384:Catalysis; D006360:Heat-Shock Proteins / Q000737:chemistry*; D008667:Metalloproteins / Q000737:chemistry*; D017015:Methanococcales; D012428:Ruthenium / Q000737:chemistry*; D013449:Sulfonamides / Q000737:chemistry; D014050:Toluene / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D000498:Allyl Compounds; D019843:Archaeal Proteins; D006360:Heat-Shock Proteins; D008667:Metalloproteins; D013449:Sulfonamides; D014050:Toluene; D012428:Ruthenium