title: Microwave-assisted Pd/Cu-catalyzed C-8 direct alkenylation of purines and related azoles: an alternative access to 6,8,9-trisubstituted purines.
abstract: An efficient microwave-assisted palladium/copper comediated C-8 direct alkenylation of purines with styryl bromides has been developed. The method is regioselective, functional group tolerant, rapid, and compatible with other related azoles. Combined with subsequent nucleophilic substitution, it provides an easy access to new 6,8,9-trisubstituted purines.
authors: Univ Paris-Sud, Orsay, F-91405, France.
authors: Roxane
authors: R
authors: Vabre
authors: Franciane
authors: F
authors: Chevot
authors: Michel
authors: M
authors: Legraverend
authors: Sandrine
authors: S
authors: Piguel
mesh_terms: D001393:Azoles / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011687:Purines / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001393:Azoles; D011687:Purines; D010165:Palladium; D003300:Copper