title: [Cerebral microdialysis in the current clinical setting].
abstract: Cerebral microdialysis, introduced in experimental studies 40 years ago, has been used clinically since 1992 for the neurochemical monitoring of patients in intensive care. The principles underlying this technique are closely related to brain metabolism. The study of the metabolites detected at brain interstitial tissue level, through the semipermeable membrane of the device, allows us to assess different physiological pathways in the brain, analyzing the changes that occur when they become less efficient in terms of energy, and also detecting waste products secondary to tissue damage. Despite its current limitations, this technique provides relevant information for research and the clinical management of critical neurological patients.
authors: Unidad de Gestión Clínica de Cuidados Críticos y Urgencias, Hospital Universitario Virgen del Rocío, Sevilla, España. drjau@hotmail.com
authors: J
authors: J
authors: Revuelto-Rey
authors: J J
authors: JJ
authors: Egea-Guerrero
authors: M A
authors: MA
authors: Muñoz-Sánchez
authors: F
authors: F
authors: Murillo-Cabezas
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D001925:Brain Damage, Chronic / Q000517:prevention & control; D001930:Brain Injuries / Q000175:diagnosis / Q000378:metabolism*; D002561:Cerebrovascular Disorders / Q000175:diagnosis / Q000378:metabolism*; D003422:Critical Care / Q000379:methods; D004734:Energy Metabolism; D005947:Glucose / Q000032:analysis; D018698:Glutamic Acid / Q000032:analysis; D005990:Glycerol / Q000032:analysis; D006801:Humans; D002534:Hypoxia, Brain / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism; D007773:Lactates / Q000032:analysis; D017551:Microdialysis / Q000295:instrumentation / Q000379:methods; D008991:Monitoring, Physiologic / Q000379:methods*; D011379:Prognosis; D011773:Pyruvates / Q000032:analysis
chemical_list: D007773:Lactates; D011773:Pyruvates; D018698:Glutamic Acid; D005947:Glucose; D005990:Glycerol