title: In vivo MRS study of intraventricular tumors.
abstract: OBJECTIVE
  To evaluate the role of MR spectroscopy (MRS) as a noninvasive tool for characterization of intraventricular brain tumors.
  
  
  METHODS
  Twenty-three intraventricular tumors, all histologically classified (11 central neurocytomas [CNC], 5 meningiomas [Men], other intraventricular tumors [OIV], including 2 anaplastic gliomas [WHO III], 1 tumor each of rhabdoid tumor, glioneuronal hamartoma, GBM, hemangiopericytoma, and subependymoma II), were studied by MRS before surgery using a point-resolved spectroscopic sequence (PRESS).
  
  
  RESULTS
  Statistically significant differences (P < 0.03) were observed for NAA/Cr and Cho/Cr between CNCs and OIV. A significant difference (P < 0.01) was observed in the presence of Gly between the CNCs and meningiomas, and CNCs and OIV. In addition, the presence of Ala was also significantly different (P < 0.01) between OIV and meningiomas, and OIV and CNCs.
  
  
  CONCLUSIONS
  The present study has shown that MRS can be useful in characterizing intraventricular tumor and distinguishing CNCs from meningiomas and other intraventricular tumors. Prior information about intraventricular tumor types could be useful to clinicians in planning treatment and resection strategy.
authors: Department of NMR, All India Institute of Medical Sciences, New Delhi, India. tariq196@yahoo.com
authors: Tariq
authors: T
authors: Shah
authors: Rama
authors: R
authors: Jayasundar
authors: Virendera Paul
authors: VP
authors: Singh
authors: Chitra
authors: C
authors: Sarkar
mesh_terms: D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology*; D002551:Cerebral Ventricle Neoplasms / Q000175:diagnosis / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D005910:Glioma / Q000175:diagnosis; D005998:Glycine / Q000737:chemistry; D006801:Humans; D007223:Infant; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008579:Meningioma / Q000175:diagnosis / Q000473:pathology; D008875:Middle Aged; D018306:Neurocytoma / Q000175:diagnosis
chemical_list: D005998:Glycine