title: Association of Alpha B-Crystallin (CRYAB) genotypes with breast cancer susceptibility in Taiwan.
abstract: OBJECTIVE
  Alpha B-Crystallin (CRYAB) is purported to be a metastasis suppressor protein, and lack or lower CRYAB expression is a prognostic biomarker for several types of cancer, such as that of the prostate and head and neck. However, the association of genomic variation of CRYAB and breast cancer is not well studied. The aim of this study was to evaluate the association of polymorphic genotypes of CRYAB with breast cancer within a Taiwanese population.
  
  
  METHODS
  In this hospital-based study, 1232 patients with breast cancer and an equal number of healthy controls in central Taiwan were genotyped via polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) and the association of CRYAB A-1215G (rs2228387), C-802G (rs14133) and intron 2 (rs2070894) polymorphisms with breast cancer risk in a central Taiwanese population was investigated.
  
  
  RESULTS
  Those individuals with CRYAB C-802G CG and GG genotypes had 1.50- and 2.22-fold risk for breast cancer than those with the CC genotype. As for the A-1215G and intron 2 polymorphisms, there was no significant association of the genotype with breast cancer risk. In allelic frequency analysis, the G allele CRYAB C-802G conferred a significantly (p=5.63×10(-10)) increased risk of breast cancer. Our results provide evidence that the G allele of CRYAB C-802G is correlated with breast cancer risk and this polymorphism may be a useful marker for early detection of breast cancer in clinical practice.
authors: Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan.
authors: Chen-Hsien
authors: CH
authors: Su
authors: Liang-Chih
authors: LC
authors: Liu
authors: Yi-Hsien
authors: YH
authors: Hsieh
authors: Hwei-Chung
authors: HC
authors: Wang
authors: Chia-Wen
authors: CW
authors: Tsai
authors: Wen-Shin
authors: WS
authors: Chang
authors: Chien-Yi
authors: CY
authors: Ho
authors: Chao-I
authors: CI
authors: Wu
authors: Chih-Hsueh
authors: CH
authors: Lin
authors: Hsien-Yuan
authors: HY
authors: Lane
authors: Da-Tian
authors: DT
authors: Bau
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D013624:Taiwan / Q000453:epidemiology; D038203:alpha-Crystallin B Chain / Q000235:genetics*
chemical_list: D038203:alpha-Crystallin B Chain