title: Molecular Darwinism: the contingency of spontaneous genetic variation.
abstract: The availability of spontaneously occurring genetic variants is an important driving force of biological evolution. Largely thanks to experimental investigations by microbial geneticists, we know today that several different molecular mechanisms contribute to the overall genetic variations. These mechanisms can be assigned to three natural strategies to generate genetic variants: 1) local sequence changes, 2) intragenomic reshuffling of DNA segments, and 3) acquisition of a segment of foreign DNA. In these processes, specific gene products are involved in cooperation with different nongenetic elements. Some genetic variations occur fully at random along the DNA filaments, others rather with a statistical reproducibility, although at many possible sites. We have to be aware that evolution in natural ecosystems is of higher complexity than under most laboratory conditions, not at least in view of symbiotic associations and the occurrence of horizontal gene transfer. The encountered contingency of genetic variation can possibly best ensure a long-term persistence of life under steadily changing living conditions.
authors: Biozentrum, University of Basel, Basel, Switzerland. werner.arber@unibas.ch
authors: Werner
authors: W
authors: Arber
mesh_terms: D005075:Biological Evolution; D019295:Computational Biology; D004247:DNA / Q000235:genetics; D019143:Evolution, Molecular; D015321:Gene Rearrangement; D022761:Gene Transfer, Horizontal; D014644:Genetic Variation; D015203:Reproducibility of Results; D017422:Sequence Analysis, DNA
chemical_list: D004247:DNA