title: Modeling the impact on the HIV epidemic of treating discordant couples with antiretrovirals to prevent transmission.
abstract: BACKGROUND
  The HPTN 052 study demonstrated a 96% reduction in HIV transmission in discordant couples using antiretroviral therapy (ART).
  
  
  OBJECTIVE
  To predict the epidemic impact of treating HIV-discordant couples to prevent transmission.
  
  
  METHODS
  Mathematical modeling to predict incidence reduction and the number of infections prevented.
  
  
  METHODS
  Demographic and epidemiological data from Ghana, Lesotho, Malawi and Rwanda were used to parameterize the model. ART was assumed to be 96% effective in preventing transmission.
  
  
  RESULTS
  Our results show there would be a fairly large reduction in incidence and a substantial number of infections prevented in Malawi. However, in Ghana a large number of infections would be prevented, but only a small reduction in incidence. Notably, the predicted number of infections prevented would be similar (and low) in Lesotho and Rwanda, but incidence reduction would be substantially greater in Lesotho than Rwanda. The higher the proportion of the population in stable partnerships (whether concordant or discordant), the greater the effect of a discordant couple's intervention on HIV epidemics.
  
  
  CONCLUSIONS
  The effectiveness of a discordant couples intervention in reducing incidence will vary among countries due to differences in HIV prevalence and the percentage of couples that are discordant (i.e. degree of discordancy). The number of infections prevented within a country, as a result of an intervention, will depend upon a complex interaction among three factors: population size, HIV prevalence and degree of discordancy. Our model provides a quantitative framework for identifying countries most likely to benefit from treating discordant couples to prevent transmission.
authors: ICAP, Mailman School of Public Health, Department of Epidemiology and Medicine at Columbia University, New York, New York 10032, USA. wme1@columbia.edu
authors: Wafaa M
authors: WM
authors: El-Sadr
authors: Brian J
authors: BJ
authors: Coburn
authors: Sally
authors: S
authors: Blower
mesh_terms: D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D005191:Family Characteristics; D005260:Female; D005869:Ghana / Q000453:epidemiology; D015658:HIV Infections / Q000453:epidemiology / Q000517:prevention & control / Q000635:transmission*; D006801:Humans; D015994:Incidence; D007927:Lesotho / Q000453:epidemiology; D008295:Malawi / Q000453:epidemiology; D008297:Male; D015233:Models, Statistical; D012307:Risk Factors; D012432:Rwanda / Q000453:epidemiology; D012747:Sexual Partners
chemical_list: D044966:Anti-Retroviral Agents