title: A marine carotenoid, fucoxanthin, induces regulatory T cells and inhibits Th17 cell differentiation in vitro.
abstract: Fucoxanthin is a non-provitamin A carotenoid contained in brown seaweeds. We found that it suppressed interleukin-17 secretion from CD4(+) T cells under IL-17-producing T (Th17) cell development conditions. By evaluating T cell differentiation in vitro, fucoxanthin and its metabolite fucoxanthinol inhibited T cell differentiation into Th17 cells. This suggests that fucoxanthin can improve inflammatory diseases due to Th17 cells.
authors: Research and Development Division, Kikkoman Corporation, Noda, Chiba, Japan. takawashima@mail.kikkoman.co.jp
authors: Tadaomi
authors: T
authors: Kawashima
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D051858:Forkhead Transcription Factors / Q000235:genetics; D005786:Gene Expression Regulation / Q000187:drug effects; D020381:Interleukin-17 / Q000096:biosynthesis; D051379:Mice; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000166:cytology* / Q000187:drug effects* / Q000378:metabolism; D058504:Th17 Cells / Q000166:cytology* / Q000187:drug effects* / Q000378:metabolism; D024341:Xanthophylls / Q000494:pharmacology*
chemical_list: D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse; D020381:Interleukin-17; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D012333:RNA, Messenger; D024341:Xanthophylls; C025164:fucoxanthin