title: Efficient oxidation of cysteine and glutathione catalyzed by a dinuclear areneruthenium trithiolato anticancer complex.
abstract: The highly cytotoxic diruthenium complex [(p-MeC(6)H(4)Pr(i))(2)Ru(2)(SC(6)H(4)-p-Me)(3)](+) (1), water-soluble as the chloride salt, is shown to efficiently catalyze oxidation of the thiols cysteine and glutathione to give the corresponding disulfides, which may explain its high in vitro anticancer activity.
authors: Departement für Chemie und Biochemie, Universität Bern, CH-3012 Bern, Switzerland.
authors: Federico
authors: F
authors: Giannini
authors: Georg
authors: G
authors: Süss-Fink
authors: Julien
authors: J
authors: Furrer
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D002384:Catalysis; D003545:Cysteine / Q000737:chemistry / Q000378:metabolism*; D004220:Disulfides / Q000138:chemical synthesis; D005978:Glutathione / Q000737:chemistry / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D009369:Neoplasms / Q000188:drug therapy; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology; D010084:Oxidation-Reduction / Q000187:drug effects; D012428:Ruthenium / Q000737:chemistry* / Q000633:toxicity
chemical_list: D000970:Antineoplastic Agents; D004220:Disulfides; D009942:Organometallic Compounds; D012428:Ruthenium; D005978:Glutathione; D003545:Cysteine