title: Dysregulation of microRNAs in adrenocortical tumors.
abstract: MicroRNAs (miRNAs) are short non-coding RNAs that are involved in the epigenetic regulation of cellular processes. Different malignancies are often associated with the deregulation of specific sets of miRNAs. The prognosis of adrenocortical cancers (ACCs) is very poor as compared to adrenocortical adenomas (ACAs), and even within ACCs there are cases with better disease specific survival. An improved understanding of the pathobiology of this disease will therefore be useful in facilitating better management of ACCs as well as distinguishing high risk versus low risk subgroups. One third of coding genes are regulated by miRNAs and therefore changes in miRNA expression may be associated with cancer development and progression. In this review we summarize the current understanding of miRNAs in adrenocortical tumors, and highlight their potential in differentiating between ACCs and ACAs, risk stratification and prognosis.
authors: Cancer Genetics Unit, Hormones & Cancer Group, Kolling Institute of Medical Research, University of Sydney, Sydney, Australia. puneetsingh@sydney.edu.au
authors: Puneet
authors: P
authors: Singh
authors: Patsy S H
authors: PS
authors: Soon
authors: Jean-Jacques
authors: JJ
authors: Feige
authors: Olivier
authors: O
authors: Chabre
authors: Jing Ting
authors: JT
authors: Zhao
authors: Nadia
authors: N
authors: Cherradi
authors: Enzo
authors: E
authors: Lalli
authors: Stan B
authors: SB
authors: Sidhu
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D018246:Adrenocortical Adenoma / Q000235:genetics / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D000818:Animals; D018572:Disease-Free Survival; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D012334:RNA, Neoplasm / Q000096:biosynthesis* / Q000235:genetics; D015996:Survival Rate
chemical_list: D035683:MicroRNAs; D012334:RNA, Neoplasm