title: Interferon-induced obsessive-compulsive symptoms in malignant melanoma.
abstract: Immunotherapy with alpha-interferon (IFN-α) is currently used as adjuvant treatment in patients with malignant melanoma. Psychiatric side effects such depression, mania or psychosis during treatment with IFN-α have been well documented in the literature. In comparison, however, data on interferon-induced obsessive-compulsive disorder are rare. We report here the case of a 23-year-old woman who developed obsessive-compulsive symptoms for the first time during interferon therapy after excision of a malignant melanoma.
authors: P
authors: P
authors: Mavrogiorgou
authors: G
authors: G
authors: Juckel
mesh_terms: D000328:Adult; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000009:adverse effects* / Q000627:therapeutic use; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology / Q000523:psychology / Q000601:surgery; D009367:Neoplasm Staging; D009771:Obsessive-Compulsive Disorder / Q000139:chemically induced* / Q000188:drug therapy / Q000209:etiology / Q000523:psychology; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007155:Immunologic Factors; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins