title: Sleep study, respiratory mechanics, chemosensitive response and quality of life in morbidly obese patients undergoing bariatric surgery: a prospective, randomized, controlled trial.
abstract: BACKGROUND
  Obesity is a major public health problem in both developed and developing countries alike and leads to a series of changes in respiratory physiology. There is a strong correlation between obesity and cardiopulmonary sleep disorders. Weight loss among such patients leads to a reduction in these alterations in respiratory physiology, but clinical treatment is not effective for a long period of time. Thus, bariatric surgery is a viable option.
  
  
  METHODS
  The present study involves patients with morbid obesity (BMI of 40 kg/m2 or 35 kg/m2 to 39.9 kg/m2 with comorbidities), candidates for bariatric surgery, screened at the Santa Casa de Misericórdia Hospital in the city of Sao Paulo (Brazil). The inclusion criteria are grade III morbid obesity, an indication for bariatric surgery, agreement to participate in the study and a signed term of informed consent. The exclusion criteria are BMI above 55 kg/m2, clinically significant or unstable mental health concerns, an unrealistic postoperative target weight and/or unrealistic expectations of surgical treatment. Bariatric surgery candidates who meet the inclusion criteria will be referred to Santa Casa de Misericórdia Hospital and will be reviewed again 30, 90 and 360 days following surgery. Data collection will involve patient records, personal data collection, objective assessment of HR, BP, neck circumference, chest and abdomen, collection and analysis of clinical preoperative findings, polysomnography, pulmonary function test and a questionnaire on sleepiness.
  
  
  CONCLUSIONS
  This paper describes a randomised controlled trial of morbidly obese patients. Polysomnography, respiratory mechanics, chemosensitive response and quality of life will be assessed in patients undergoing or not undergoing bariatric surgery.
  
  
  BACKGROUND
  The protocol for this study is registered with the Brazilian Registry of Clinical Trials - ReBEC (RBR-9k9hhv).
authors: Nove de Julho University, Sao Paulo, Brazil. oliveira.lvf@pq.cnpq.br
authors: Luis V F
authors: LV
authors: Oliveira
authors: Isabella C
authors: IC
authors: Aguiar
authors: Raquel P
authors: RP
authors: Hirata
authors: Newton S
authors: NS
authors: Faria Junior
authors: Israel S
authors: IS
authors: Reis
authors: Luciana M M
authors: LM
authors: Sampaio
authors: Claudia S
authors: CS
authors: Oliveira
authors: Paulo T C
authors: PT
authors: Carvalho
authors: Fernando S S
authors: FS
authors: Leitao Filho
authors: Lilian C
authors: LC
authors: Giannasi
authors: Lia Azevedo
authors: LA
authors: Pinto
authors: Carlos Alberto
authors: CA
authors: Malheiros
authors: Wilson Rodrigues
authors: WR
authors: Freitas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D050110:Bariatric Surgery; D002245:Carbon Dioxide / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000150:complications / Q000503:physiopathology* / Q000601:surgery*; D017286:Polysomnography; D011446:Prospective Studies; D011788:Quality of Life; D015656:Respiratory Mechanics / Q000187:drug effects; D013147:Spirometry
chemical_list: D002245:Carbon Dioxide