title: Constituents with DNA topoisomerases I and II inhibitory activity and cytotoxicity from the roots of Rubia cordifolia.
abstract: Activity-directed isolation of the ethyl acetate fraction from the roots of Rubia cordifolia resulted in the identification of a new anthraquinone, 1,3,6-trihydroxy-2-hydroxymethyl-9,10-anthraquinone-3- O- α- L-rhamnopyranosyl-(1 → 2)- β-D-(6'-O-acetyl)-glucopyranoside (1), two new dihydronaphtoquinones, 1,4-dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O- β-D-glucopyranoside (2) and mollugin-1-O- β- D-glucopyranoside (3), and a new monoterpenoid, 3 R,3a S,4 R,6a R-3,4,6-tris(hydroxymethyl)-3,3a,4,6a-tetrahydro-2 H-cyclopenta[ B]furan-2-one (4), together with nine known compounds (5-13). The structures of these compounds were elucidated on the basis of spectroscopic evidence. In addition, their DNA topoisomerases I and II inhibitory activity and cytotoxicity were measured.
authors: College of Pharmacy, Catholic University of Daegu, Gyeongsan, Korea.
authors: Su-Yang
authors: SY
authors: Jeong
authors: Bing-Tian
authors: BT
authors: Zhao
authors: Chong-Soon
authors: CS
authors: Lee
authors: Jong-Keun
authors: JK
authors: Son
authors: Byung-Sun
authors: BS
authors: Min
authors: Mi-Hee
authors: MH
authors: Woo
mesh_terms: D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D045470:Rubia / Q000737:chemistry*; D059004:Topoisomerase I Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D059005:Topoisomerase II Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000880:Anthraquinones; D000972:Antineoplastic Agents, Phytogenic; D039821:Monoterpenes; D010936:Plant Extracts; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors