title: Pyrazinamide-induced anaphylaxis: diagnosed by skin test and successful desensitization.
abstract: Pyrazinamide (PZA), an antituberculosis drug, may cause hypersensitivity reactions. Here, we report a case of anaphylaxis secondary to a PZA administration for tuberculosis pleuritis. To the best of our knowledge, this is the first reported case of strongly possible IgE-mediated, PZA-induced anaphylaxis proved by skin prick test and oral provocation/desensitization.
authors: Division of Immunology and Allergy, Department of Chest Diseases, Ankara University School of Medicine, Ankara, Turkey. bavbek@medicine.ankara.edu.tr
authors: Sevim
authors: S
authors: Bavbek
authors: Insu
authors: I
authors: Yılmaz
authors: Ömür
authors: Ö
authors: Aydın
authors: Seçil Kepil
authors: SK
authors: Ozdemir
mesh_terms: D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D003888:Desensitization, Immunologic; D005260:Female; D006801:Humans; D011718:Pyrazinamide / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D012882:Skin Tests
chemical_list: D000995:Antitubercular Agents; D011718:Pyrazinamide