title: Mapping the surface adsorption forces of nanomaterials in biological systems.
abstract: The biological surface adsorption index (BSAI) is a novel approach to characterize surface adsorption energy of nanomaterials that is the primary force behind nanoparticle aggregation, protein corona formation, and other complex interactions of nanomaterials within biological systems. Five quantitative nanodescriptors were obtained to represent the surface adsorption forces (hydrophobicity, hydrogen bond, polarity/polarizability, and lone-pair electrons) of the nanomaterial interaction with biological components. We have mapped the surface adsorption forces over 16 different nanomaterials. When the five-dimensional information of the nanodescriptors was reduced to two dimensions, the 16 nanomaterials were classified into distinct clusters according their surface adsorption properties. BSAI nanodescriptors are intrinsic properties of nanomaterials useful for quantitative structure-activity relationship (QSAR) model development. This is the first success in quantitative characterization of the surface adsorption forces of nanomaterials in biological conditions, which could open a quantitative avenue in predictive nanomedicine development, risk assessment, and safety evaluation of nanomaterials.
authors: Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, North Carolina 27607, USA.
authors: Xin R
authors: XR
authors: Xia
authors: Nancy A
authors: NA
authors: Monteiro-Riviere
authors: Sanjay
authors: S
authors: Mathur
authors: Xuefeng
authors: X
authors: Song
authors: Lisong
authors: L
authors: Xiao
authors: Steven J
authors: SJ
authors: Oldenberg
authors: Bengt
authors: B
authors: Fadeel
authors: Jim E
authors: JE
authors: Riviere
mesh_terms: D000327:Adsorption; D001695:Biology; D049329:Nanostructures / Q000737:chemistry*; D013499:Surface Properties