title: Photochemically induced radical transformation of C(sp3)-H bonds to C(sp3)-CN bonds.
abstract: A general protocol for direct transformation of unreactive C(sp(3))-H bonds to C(sp(3))-CN bonds has been developed. The C-H activation was effected by photoexcited benzophenone, and the generated carbon radical was subsequently trapped with tosyl cyanide to afford the corresponding nitrile in a highly efficient manner. The present methodology is widely applicable to versatile starting materials and, thus, serves as a powerful tool for selective one-carbon elongation for construction of architecturally complex molecules.
authors: Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Tokyo 113-0033, Japan.
authors: Shin
authors: S
authors: Kamijo
authors: Tamaki
authors: T
authors: Hoshikawa
authors: Masayuki
authors: M
authors: Inoue
mesh_terms: D003486:Cyanides / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry*; D015394:Molecular Structure; D055668:Photochemical Processes; D011392:Proline / Q000737:chemistry
chemical_list: D003486:Cyanides; D005609:Free Radicals; D006859:Hydrogen; D011392:Proline