title: A randomized, controlled pilot trial of hormone therapy for menopausal insomnia.
abstract: Insomnia is a frequent climacteric symptom. This pilot, double-blind, randomized placebo-controlled trial compared estradiol associated with trimegestone or placebo in 12 women with perimenopausal insomnia. The Pittsburgh Sleep Quality Index (PSQI) was administered, and polysomnography was performed at baseline and after 28 days. Sleep efficiency and median score of the PSQI improved significantly in the hormone therapy group (HT) (p=0.041 and p=0.027, respectively) and not in placebo group. Perimenopausal insomnia improved after short-term HT.
authors: Postgraduate Program in Medical Sciences, Obstetrics and Gynecology Department, UFRGS, and Menopause Clinic, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil.
authors: Betania Huber
authors: BH
authors: Silva
authors: Denis
authors: D
authors: Martinez
authors: Maria Celeste Osório
authors: MC
authors: Wender
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D004958:Estradiol / Q000008:administration & dosage*; D015914:Estrogen Replacement Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008875:Middle Aged; D047648:Perimenopause; D010865:Pilot Projects; D017286:Polysomnography; D011397:Promegestone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D012890:Sleep / Q000187:drug effects; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: C050319:trimegestone; D004958:Estradiol; D011397:Promegestone