title: Effects of augmented exercise therapy on outcome of gait and gait-related activities in the first 6 months after stroke: a meta-analysis.
abstract: OBJECTIVE
  The purpose of this study was to determine the effects of augmented exercise therapy on gait, gait-related activities, and (basic and extended) activities of daily living within the first 6 months poststroke.
  
  
  METHODS
  A systematic literature search in electronic databases from 1990 until October 2010 was performed. Randomized controlled trials were included in which the experimental group spent augmented time in lower-limb exercise therapy compared with the control group. Outcomes were gait, gait-related activities, and (extended) activities of daily living. Results from individual studies were pooled by calculating the summary effect sizes. Subgroup analyses were applied for a treatment contrast of ≥16 hours, timing poststroke, type of control intervention, and methodological quality.
  
  
  RESULTS
  Fourteen (N=725) of 4966 identified studies were included. Pooling resulted in small to moderate significant summary effect sizes in favor of augmented exercise therapy for walking ability, comfortable and maximum walking speed, and extended activities of daily living. No significant effects were found for basic activities of daily living. Subgroup analysis did not show a significant effect modification.
  
  
  CONCLUSIONS
  Dose-response trials in stroke rehabilitation are heterogeneous. The present meta-analysis suggests that increased time spent on exercise of gait and gait-related activities in the first 6 months poststroke results in significant small to moderate effects in terms of walking ability, walking speed, and extended activities of daily living. High-quality dose-response exercise therapy trials are needed with identical treatment goals but incremental levels of intensity.
authors: Department of Rehabilitation Medicine, Research Institute MOVE, VU University Medical Center, 1007 MB Amsterdam, The Netherlands.
authors: Janne M
authors: JM
authors: Veerbeek
authors: Muriel
authors: M
authors: Koolstra
authors: Johannes C F
authors: JC
authors: Ket
authors: Erwin E H
authors: EE
authors: van Wegen
authors: Gert
authors: G
authors: Kwakkel
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic / Q000379:methods / Q000639:trends; D016208:Databases, Factual / Q000639:trends; D005081:Exercise Therapy / Q000379:methods / Q000639:trends*; D005684:Gait / Q000502:physiology*; D006801:Humans; D020521:Stroke / Q000503:physiopathology*; D000071939:Stroke Rehabilitation; D013997:Time Factors; D016896:Treatment Outcome; D016138:Walking / Q000502:physiology