title: High predictive accuracy of Aldosteronoma Resolution Score in Japanese patients with aldosterone-producing adenoma.
abstract: BACKGROUND
  Primary aldosteronism caused by aldosterone-producing adenoma is the most common curable cause of secondary hypertension, but despite resection, many patients continue to require antihypertensive medications to control their blood pressure postoperatively. The Aldosteronoma Resolution Score is a preoperative 4-item predictive model for the complete postoperative resolution of hypertension. Our aim was to validate the accuracy of this model in predicting postoperative resolution of hypertension in Japanese patients.
  
  
  METHODS
  The records of 91 Japanese patients who underwent unilateral adrenalectomy for aldosterone-producing adenoma were surveyed retrospectively. Patients were distributed into 2 groups according to whether blood pressure was normal without antihypertensive medications at 6 months postoperatively. Clinical and biochemical data were evaluated at baseline and after the 6-month follow-up.
  
  
  RESULTS
  At 6 months, blood pressure had normalized in 45% of the patients without antihypertensive medications. Multivariate logistic regression analysis revealed that patients who had complete resolution of hypertension were significantly more likely to have been taking ≤2 antihypertensive medications preoperatively, have a duration of hypertension of <6 years, and be female. The predictive accuracy of the Aldosteronoma Resolution Score was assessed using the area under the curve of receiver operator characteristics analysis. The value of the area under the curve was 0.81.
  
  
  CONCLUSIONS
  Our external validation revealed that the Aldosteronoma Resolution Score developed using Western data can identify accurately Japanese individuals with aldosterone-producing adenoma who are likely to have complete resolution of hypertension after adrenalectomy.
authors: Department of Urology, Graduate School of Medicine, Chiba University, Chiba, Japan.
authors: Takanobu
authors: T
authors: Utsumi
authors: Koji
authors: K
authors: Kawamura
authors: Takashi
authors: T
authors: Imamoto
authors: Naoto
authors: N
authors: Kamiya
authors: Akira
authors: A
authors: Komiya
authors: Sawako
authors: S
authors: Suzuki
authors: Hidekazu
authors: H
authors: Nagano
authors: Tomoaki
authors: T
authors: Tanaka
authors: Naoki
authors: N
authors: Nihei
authors: Yukio
authors: Y
authors: Naya
authors: Hiroyoshi
authors: H
authors: Suzuki
authors: Ichiro
authors: I
authors: Tatsuno
authors: Tomohiko
authors: T
authors: Ichikawa
mesh_terms: D000236:Adenoma / Q000150:complications / Q000378:metabolism* / Q000601:surgery*; D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000378:metabolism* / Q000601:surgery*; D000315:Adrenalectomy; D000959:Antihypertensive Agents / Q000627:therapeutic use; D044466:Asian People; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006929:Hyperaldosteronism / Q000209:etiology / Q000601:surgery; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology / Q000601:surgery; D007564:Japan; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents