title: [The influnence of dachengqi tang on acute lung injury and intra abdominal hypertension in rats with acute pancreatitis].
abstract: OBJECTIVE
  To test the hypothesis "lung and large intestine are interior exteriorly related" through investgating into the effect of Dacheng qi tang (DCQT) on intra abdominal hypertension (IAH) and acute lung injury (ALI) in rats with acute pancreatitis.
  
  
  METHODS
  Male SD rats were randomly divided into three groups with ten rats for each group: rats with sham-operations (SO); rats with acute necrosis pancreatitis (ANP); rats with ANP plus DCQT treatment. ANP was induced by retrograde infusion of 5% taurocholic acid into pancreatic duct. Two hours after operations, 10 mL/kg of normal saline was orally adminstered to the rats in both SO and ANP groups, whereas 10 mL/kg DCQT was adminstered to the rats in the treatment group. Aterial blood, pancreas and lung tissues were collected for biomarkers and histopathology 24 hours after operations. Intra-abdominal pressure and intestinal propulsion rate were also measured. RESULTS; DCQT treatment reduced intra-abdominal pressure and improved intestinal propulsion rate compared with those treated with saline (P < 0.05). The ANP rats treated with DCQT had lower wet to dry weight ratio, and milder myeloperoxidase activity and histopathology changes in pancreas and lung than those treated with saline (P < 0.05). Higher pressure of oxygen (PO2) was found in the rats treated with DCQT, while no difference in PCO2 was found between the DCQT and ANP groups (P > 0.05). Only two rats in the ANP group died.
  
  
  CONCLUSIONS
  DCQT can effectively relieve IAH and cure ALI at the same time in rats with acute pancreatitis. The result provides evidence to support the hypothesis "lung and large intestine are interior exteriorly related".
authors: Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
authors: Mei-Hua
authors: MH
authors: Wan
authors: Juan
authors: J
authors: Li
authors: Wen-Fu
authors: WF
authors: Tang
authors: Han-Lin
authors: HL
authors: Gong
authors: Guang-Yuan
authors: GY
authors: Chen
authors: Ping
authors: P
authors: Xue
authors: Xian-Lin
authors: XL
authors: Zhao
authors: Qing
authors: Q
authors: Xia
mesh_terms: D055371:Acute Lung Injury / Q000188:drug therapy* / Q000209:etiology; D000818:Animals; D059325:Intra-Abdominal Hypertension / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D019283:Pancreatitis, Acute Necrotizing / Q000150:complications* / Q000188:drug therapy; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D010936:Plant Extracts; C477169:dachengqi decoction