title: Optimal design of a spectral readout type planar waveguide-mode sensor with a monolithic structure.
abstract: Optical planar waveguide-mode sensor is a promising candidate for highly sensitive biosensing techniques in fields such as protein adsorption, receptor-ligand interaction and surface bacteria adhesion. To make the waveguide-mode sensor system more realistic, a spectral readout type waveguide sensor is proposed to take advantage of its high speed, compactness and low cost. Based on our previously proposed monolithic waveguide-mode sensor composed of a SiO2 waveguide layer and a single crystalline Si layer [1], the mechanism for achieving high sensitivity is revealed by numerical simulations. The optimal achievable sensitivities for a series of waveguide structures are summarized in a contour map, and they are found to be better than those of previously reported angle-scan type waveguide sensors.
authors: National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8562, Japan. x.wang@aist.go.jp
authors: Xiaomin
authors: X
authors: Wang
authors: Makoto
authors: M
authors: Fujimaki
authors: Takafumi
authors: T
authors: Kato
authors: Ken-Ichi
authors: K
authors: Nomura
authors: Koichi
authors: K
authors: Awazu
authors: Yoshimichi
authors: Y
authors: Ohki
mesh_terms: D000327:Adsorption; D001422:Bacterial Adhesion; D015374:Biosensing Techniques; D003198:Computer Simulation; D060733:Electromagnetic Radiation; D008024:Ligands; D008422:Materials Testing; D008962:Models, Theoretical; D055095:Optics and Photonics / Q000379:methods*; D011506:Proteins / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D013499:Surface Properties; D014867:Water / Q000737:chemistry
chemical_list: D008024:Ligands; D011506:Proteins; D014867:Water; D012822:Silicon Dioxide