title: [The studies for activating and inhibitory receptors on natural killer cells in HIV/HCV co-infected patients].
abstract: OBJECTIVE
  To investigate the characteristics of inhibitory and activating receptor expressions on natural killer (NK) cells in HIV/HCV co-infected patients.
  
  
  METHODS
  Numbers, frequencies and expressions of activating and inhibitory receptors of NK cells were measured with flow cytometry (FCS) from HIV/HCV co-infected group (n = 24), HCV mono-infected group (n = 34), HIV mono-infected group (n = 21) and healthy control group (HC, n = 20), then analysis and compare were performed among those groups.
  
  
  RESULTS
  The NK cell absolute counts in HIV/HCV group were significantly lower than those in other three groups. The NKP30 and NKP46 frequencies on NK cells in HIV/HCV, HIV and HCV groups were all significantly lower than those in HC group, but there were no significant differences of NKP30 among former three groups; and NKP46 frequencies in HIV/HCV and HIV groups were lower than those in HCV group, but there were no significant differences between former two groups. The NKG2A frequencies in HIV/HCV and HCV groups were all higher than those in HIV and HC groups significantly, but the NKG2A frequencies in HIV group were lower than those in HC group; There were no significant differences of NKG2D, CD158a and CD158b among those four groups.
  
  
  CONCLUSIONS
  NK cell numbers and expressions of activiting receptors on NK cells obviously decreased in HIV/HCV co-infected patients, but some inhibitory receptors expressions increased, even higher than those of HIV mono-infected patients. NK cells impairments in HIV/HCV co-infection is more severe than HIV or HCV mono-infection.
authors: PLA Medical School for Advanced Study, Beijing 100853, China.
authors: Peng
authors: P
authors: Zhao
authors: Xin
authors: X
authors: Zhang
authors: Fu-Biao
authors: FB
authors: Kang
authors: Xin-Wei
authors: XW
authors: Zhang
authors: Liu
authors: L
authors: Zhang
authors: Wen-Hui
authors: WH
authors: Tan
authors: Wei-Wei
authors: WW
authors: Chen
authors: Min
authors: M
authors: Zhao
mesh_terms: D000328:Adult; D005260:Female; D005434:Flow Cytometry; D015658:HIV Infections / Q000235:genetics / Q000378:metabolism*; D006526:Hepatitis C / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007694:Killer Cells, Natural / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D055654:NK Cell Lectin-Like Receptor Subfamily C / Q000235:genetics / Q000378:metabolism; D055655:NK Cell Lectin-Like Receptor Subfamily K / Q000235:genetics / Q000378:metabolism; D055627:Natural Cytotoxicity Triggering Receptor 1 / Q000235:genetics / Q000378:metabolism; D055628:Natural Cytotoxicity Triggering Receptor 3 / Q000235:genetics / Q000378:metabolism; D054342:Receptors, KIR2DL1 / Q000235:genetics / Q000378:metabolism; D054344:Receptors, KIR2DL3 / Q000235:genetics / Q000378:metabolism; D055815:Young Adult
chemical_list: C527085:KLRK1 protein, human; C112260:NCR1 protein, human; C431710:NCR3 protein, human; D055654:NK Cell Lectin-Like Receptor Subfamily C; D055655:NK Cell Lectin-Like Receptor Subfamily K; D055627:Natural Cytotoxicity Triggering Receptor 1; D055628:Natural Cytotoxicity Triggering Receptor 3; D054342:Receptors, KIR2DL1; D054344:Receptors, KIR2DL3