title: The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional Insights.
abstract: Since its initial description as an HIV-1 integrase (IN) interactor seven years ago, LEDGF has become one of the best-characterized host factors involved in viral replication. Results of intensive studies in several laboratories indicated that the protein serves as a targeting factor for the lentiviral DNA integration machinery, and accounts for the characteristic preference of Lentivirus to integrate within active transcription units. The IN-LEDGF interaction has been put forward as a promising target for antiretroviral drug development and as a potential tool to improve safety of lentiviral vectors for use in gene therapy. Additionally, as a natural ligand of lentiviral IN proteins, LEDGF has been successfully used in structural biology studies of retroviral DNA integration. This review focuses on the structural aspects of the IN-LEDGF interaction and their functional consequences.
authors: Division of Medicine, Imperial College London, St. Mary's Campus, Norfolk Place, London, W2 1PG, UK; E-mail:  s.hare@imperial.ac.uk.
authors: Stephen
authors: S
authors: Hare
authors: Peter
authors: P
authors: Cherepanov