title: A cross-sectional study of the association between heat shock protein 27 antibody titers, pro-oxidant-antioxidant balance and metabolic syndrome in patients with angiographically-defined coronary artery disease.
abstract: OBJECTIVE
  To investigate the association between serum antibody titers to Hsp27 (anti-Hsp27) and pro-oxidant-antioxidant balance (PAB) in patients with angiographically-defined coronary artery disease (CAD) with or without the metabolic syndrome (MS).
  
  
  METHODS
  Subjects (n=243) were classified into MS+ (n=161) and MS- (n=82) subgroups, based on the AHA/NHBLI criteria.
  
  
  RESULTS
  Serum anti-Hsp27 titers were found to be significantly higher in the MS+ vs. MS- group. However, no significant difference was observed in serum PAB values. When assessed for individual components of MS, increased serum anti-Hsp27 was found to be higher in subgroups with elevated triglycerides, elevated blood pressure and reduced high-density lipoprotein cholesterol (HDL-C). Subgroups of patients with elevated triglycerides had higher PAB values. HDL-C was the only significant predictor of anti-Hsp27 in the population as a whole.
  
  
  CONCLUSIONS
  The evidence from this investigation indicates the presence of elevated anti-Hsp27 in patients with concurrent CAD and MS compared to those with CAD alone.
authors: Cardiovascular Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Amirhossein
authors: A
authors: Sahebkar
authors: Hossein
authors: H
authors: Pourghadamyari
authors: Mohsen
authors: M
authors: Moohebati
authors: Seyed Mohammad Reza
authors: SM
authors: Parizadeh
authors: Homa
authors: H
authors: Falsoleiman
authors: Mashallah
authors: M
authors: Dehghani
authors: Afsoon
authors: A
authors: Fazlinezhad
authors: Saeed
authors: S
authors: Akhlaghi
authors: Shima
authors: S
authors: Tavallaie
authors: Roghayeh
authors: R
authors: Paydar
authors: Majid
authors: M
authors: Ghayour-Mobarhan
authors: Gordon A
authors: GA
authors: Ferns
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000276:immunology*; D003430:Cross-Sectional Studies; D005260:Female; D055551:HSP27 Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications / Q000276:immunology*; D008875:Middle Aged; D015999:Multivariate Analysis; D016877:Oxidants / Q000097:blood*
chemical_list: D000975:Antioxidants; D001323:Autoantibodies; D015415:Biomarkers; D055551:HSP27 Heat-Shock Proteins; D016877:Oxidants