title: Intercellular adhesion molecule-1 E469K gene polymorphism and coronary artery disease in the Chinese population: a meta-analysis involving 3065 subjects.
abstract: BACKGROUND
  The intercellular adhesion molecule-1 (ICAM-1) E469K gene polymorphism has been implicated in increased coronary artery disease (CAD) susceptibility, but the individual study results are still controversial.
  
  
  OBJECTIVE
  The ICAM-1 E469K gene polymorphism may be associated with CAD risk.
  
  
  METHODS
  The current meta-analysis involving 3065 subjects and 11 separate studies was conducted to explore the relationship between the ICAM-1 E469K gene polymorphism and CAD in the Chinese population. The pooled odds ratio (ORs) for the distribution of K allele frequency of ICAM-1 E469K gene and its corresponding 95% confidence interval (CI) was assessed by random effect model.
  
  
  RESULTS
  The distribution of the K allele frequency was 0.67 for the CAD group and 0.60 for the control group. The pooled OR for the distribution of the K allele frequency of the ICAM-1 E469K gene was 1.32 (95% CI, 1.02-1.72; P(heterogeneity) < 0.00001; inconsistency index I(2) = 81.8%). The association between the ICAM-1 E469K gene polymorphism and CAD in the Chinese population was significant (P = 0.04).
  
  
  CONCLUSIONS
  In the Chinese population, the distribution of the K allele frequency of the ICAM-1 E469K gene was indicated to be associated with CAD risk. The K allele of the ICAM-1 E469K gene might predispose to the CAD susceptibility.
authors: Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University, China. lyynjmu123@126.com
authors: Li
authors: L
authors: Yanyan
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China; D003324:Coronary Artery Disease / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D018799:Intercellular Adhesion Molecule-1