title: High-grade invasive urothelial carcinoma with focal plasmacytoid differentiation successfully treated by transurethral resection followed by chemoradiotherapy.
abstract: We report a case of high-grade invasive urothelial carcinoma with plasmacytoid differentiation of the urinary bladder. A 75-year-old woman was referred to our hospital because of macroscopic hematuria. Cystoscopy detected a solid pedunculated bladder tumor, and a transurethral resection of the bladder tumor (TUR-Bt) and the image findings showed pT1N0M0 bladder cancer. The histopathological examination revealed the coexistence of a large component of high-grade invasive urothelial carcinoma and a small component of plasmacytoid carcinoma. Following the TUR-Bt, external beam radiotherapy and chemotherapy with gemcitabine and nedaplatin were carried out. The bladder tumor has not recurred for 2 years after the TUR-Bt.
authors: Department of Urology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan. takashi_tk2001@yahoo.co.jp
authors: Takashi
authors: T
authors: Kawahara
authors: Hisashi
authors: H
authors: Oshiro
authors: Zenkichi
authors: Z
authors: Sekiguchi
authors: Hiroki
authors: H
authors: Ito
authors: Kazuhide
authors: K
authors: Makiyama
authors: Hiroji
authors: H
authors: Uemura
authors: Yoshinobu
authors: Y
authors: Kubota
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002277:Carcinoma / Q000473:pathology* / Q000628:therapy*; D059186:Chemoradiotherapy, Adjuvant; D015653:Cystectomy; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000628:therapy*; D019459:Urothelium / Q000473:pathology; D000093542:Gemcitabine
chemical_list: D009944:Organoplatinum Compounds; D003841:Deoxycytidine; C053989:nedaplatin; D000093542:Gemcitabine