title: A simple, rapid procedure for nucleophilic radiosynthesis of aliphatic [18F]trifluoromethyl groups.
abstract: A procedure for the radiosynthesis of aliphatic [(18)F]trifluoromethyl groups by reacting 1,1-difluorovinyl precursors with [(18)F]fluoride ions, resulting in the equivalent of direct nucleophilic addition of H[(18)F]F, has been developed. A variety of (18)F-labelled model compounds were then obtained and two potential [(18)F]radiotracers were synthesised by a two step process starting from 1,1-difluorovin-2-yl 4-toluenesulfonate. The method is widely applicable for the synthesis of novel radiotracers in high radiochemical yields and good specific activity.
authors: Wolfson Brain Imaging Centre, University of Cambridge, Box 65 Addenbrooke's Hospital, CB2 0QQ, Cambridge, UK. pr340@wbic.cam.ac.uk
authors: Patrick J
authors: PJ
authors: Riss
authors: Franklin I
authors: FI
authors: Aigbirhio
mesh_terms: D005462:Fluorine Radioisotopes / Q000737:chemistry; D007553:Isotope Labeling; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals