title: [Association of filaggrin gene polymorphism with atopic dermatitis in southern Chinese Han population].
abstract: OBJECTIVE
  To investigate the association of filaggrin gene (FLG) polymorphism with atopic dermatitis (AD) in southern Chinese Han population.
  
  
  METHODS
  The frequencies of the 13 known FLG gene single nucleotide polymorphism(SNPs), including 3321delA, 441delA, 1249insG, E1795X, S3296X, R501X, 2282del4, R2447X, S2889X, 7945delA, 3702delG, Q2417X, R4307X, were detected in a cohort of 50 AD patients and 100 control individuals using polymerase chain reaction (PCR) and DNA sequencing.
  
  
  RESULTS
  FLG 3321delA and 441delA were detected in 14 (28%) and 6 (12%) AD patients, respectively. The other 11 SNPs were not detected in the patients. None of the 13 SNPs was detected in the controls.
  
  
  CONCLUSIONS
  The results suggested that the FLG gene might be associated with atopic dermatitis susceptibility in southern Chinese Han population.
authors: Department of Dermatology, Dongguan Institute of Dermatology, Dongguan, Guangdong, People's Republic of China. lilichangxing@163.com
authors: Chang-xing
authors: CX
authors: Li
authors: Xue-mei
authors: XM
authors: Li
authors: Xi-bao
authors: XB
authors: Zhang
authors: Chun-lei
authors: CL
authors: Han
authors: Ze-lin
authors: ZL
authors: Ma
authors: Dong-zi
authors: DZ
authors: Lin
mesh_terms: D000293:Adolescent; D044466:Asian People / Q000235:genetics; D001483:Base Sequence; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000235:genetics*; D005260:Female; D000091344:Filaggrin Proteins; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007381:Intermediate Filament Proteins / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins