title: Magnetic resonance imaging demonstrates long-term  changes in brain structure in children born  preterm and exposed to chorioamnionitis.
abstract: OBJECTIVE
  We sought to determine if children born preterm and exposed to chorioamnionitis have differences in brain structure measured at 6-10 years of age using magnetic resonance imaging (MRI).
  
  
  METHODS
  Structural MRI was performed with 11 preterm children (8.5 ± 1.7 years) with chorioamnionitis and 16 preterm children (8.7 ± 1.4 years) without chorioamnionitis. Cortical surface reconstruction and volumetric segmentation were performed with FreeSurfer image analysis software. Subcortical structures were analyzed using multivariate analysis.
  
  
  RESULTS
  Widespread regional differences in cortical thickness were observed. With chorioamnionitis, the frontal and temporal lobes were primarily affected by decreased cortical thickness, and the limbic, parietal, and occipital lobes were primarily affected by increased cortical thickness when compared to the comparison group. Subcortical differences were observed in the hippocampus and lateral ventricle.
  
  
  CONCLUSIONS
  Using MRI, chorioamnionitis is associated with longterm widespread regional effects on brain development in children born prematurely. Our study is limited by its small sample size.
authors: Department of Obstetrics and Gynecology, Women and Children's Health and Well-Being Project, University of California, Irvine, School of Medicine, Irvine, CA 92868, USA. thatfiel@uci.edu
authors: Tamera
authors: T
authors: Hatfield
authors: Deborah A
authors: DA
authors: Wing
authors: Claudia
authors: C
authors: Buss
authors: Kevin
authors: K
authors: Head
authors: L Tugan
authors: LT
authors: Muftuler
authors: Elysia Poggi
authors: EP
authors: Davis
mesh_terms: D001921:Brain / Q000473:pathology*; D002648:Child; D002821:Chorioamnionitis; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008279:Magnetic Resonance Imaging; D008297:Male; D011247:Pregnancy