title: Early adverse effect of abnormal glucose metabolism on arterial stiffness in drug naive hypertensive patients.
abstract: Arterial stiffness is independently related to increased cardiovascular risk in the hypertensive population. The aim of the present study was to investigate whether various stages of abnormal glucose metabolism may differently affect arterial stiffness in hypertensive patients and whether there is any difference in arterial stiffness among patients with normal glucose regulation. We studied 1375 never-treated hypertensive subjects. Participants were divided into four metabolic groups: normal glucose regulation (NG), impaired fasting glucose, impaired glucose tolerance and type-2 diabetes mellitus (DM 2). Hypertensive subjects with NG were subdivided into three groups according to glucose levels. Arterial stiffness was estimated by carotid-femoral pulse wave velocity (PWV). PWV showed a significant increase from patients with NG to DM 2 (from 7.74 ± 1.38 to 8.40 ± 1.30 to 8.86 ± 1.30 to 10.09 ± 2.07 m/s respectively, p<0.001). Among hypertensive subjects with NG there was an increase in PWV from low normal to high normal values of glucose (p<0.01). PWV was independently related to all glucose metabolic parameters (p<0.001 for all). In the present study, we demonstrated an association between arterial stiffness and glucose tolerance in hypertensive subjects. Given the prognostic significance of arterial stiffness, aims should be towards closer monitoring and intensive care of hypertensive patients with abnormal glucose metabolism.
authors: Hypertension and Peripheral Vessels Unit, 1st Cardiology Department, Athens Medical School, Hippokration Hospital, Athens, Greece.
authors: Gregory
authors: G
authors: Vyssoulis
authors: Panagiota
authors: P
authors: Pietri
authors: Charalambos
authors: C
authors: Vlachopoulos
authors: Nikolaos
authors: N
authors: Alexopoulos
authors: Stella-Maria
authors: SM
authors: Kyvelou
authors: Dimitris
authors: D
authors: Terentes-Printzios
authors: Christodoulos
authors: C
authors: Stefanadis
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D002339:Carotid Arteries / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D004548:Elasticity; D005260:Female; D005263:Femoral Artery / Q000503:physiopathology*; D018149:Glucose Intolerance / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D006115:Greece; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011673:Pulsatile Flow
chemical_list: D001786:Blood Glucose