title: [Clinical manifestations of atopy in children up to two years of age].
abstract: OBJECTIVE
  Atopic diseases such as atopic dermatitis, allergic rhinitis and asthma have had increased prevalence during the past decade and nowadays occur in every third child in developed countries. The aim of the study was to determine frequency and type of atopic diseases at the age of two, as well as the importance the total IgE antibodies concentrations have in diagnosis and prognosis of the disease.
  
  
  METHODS
  The study involved 175 children up to two years of age. Allergy-like symptoms were found after surveying their parents and pediatric medical records. Using the fluorescence immunossay (FIA) method, total IgE antibodies concentrations and specific IgE antibodies (Phadiatop infant) were determined on an Immunocap 100 Dyagnostic System.
  
  
  RESULTS
  One or more allergy-like symptoms accounted for 57.7% of findings in children under the age of two, whilst in 19.4% the existence of IgE-related allergic diseases was found. Atopic diseases usually have clinical manifestations of atopic dermatitis (11.4%), IgE-bound wheezing/asthma (10.8%) and food allergies (7.4%), and to much lesser extent those of allergic rhinitis (3.4%) and urticaria (1.7%). The significantly higher total IgE antibodies concentrations were found in children with allergy-like symptoms (p < 0.0005) (cut-off 15.15 kU/L, sensitivity 76.5% specificity 71.6%).
  
  
  CONCLUSIONS
  Almost 20% of two-year-old children have any of clinically manifested allergic diseases, with atopic dermatitis and IgE wheeze/asthma being predominant. The higher total IgE antibodies concentration is a good marker for sensitization in children with allergy-like symptoms.
authors: Institut za javno zdravlje, Kragujevac, Srbija. ilic_nevenka@yahoo.com
authors: Nevenka
authors: N
authors: Ilić
authors: Vesna
authors: V
authors: Velicković
authors: Dragoljub I
authors: DI
authors: Djokić
authors: Nebojsa
authors: N
authors: Ranković
authors: Gordana
authors: G
authors: Kostić
authors: Marina
authors: M
authors: Petrović
authors: Milica
authors: M
authors: Radunović
authors: Dejan
authors: D
authors: Baskić
mesh_terms: D015415:Biomarkers / Q000097:blood; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis*; D007118:Immunoassay; D007073:Immunoglobulin E / Q000097:blood; D007223:Infant; D008297:Male; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D007073:Immunoglobulin E