title: Cellular players in the herpes simplex virus dependent apoptosis balancing act.
abstract: Apoptosis is triggered as an intrinsic defense against numerous viral infections. Almost every virus encodes apoptotic modulators, and the herpes simplex viruses (HSV) are no exception. During HSV infection, there is an intricate balance between pro- and anti-apoptotic factors that delays apoptotic death until the virus has replicated. Perturbations in the apoptotic balance can cause premature cell death and have the potential to dramatically alter the outcome of infection. Recently, certain cellular genes have been shown to regulate sensitivity to HSV-dependent apoptosis. This review summarizes current knowledge of the cellular genes that impact the apoptotic balance during HSV infection.
authors: Department of Microbiology and Immunology, Des Moines University, Des Moines, IA, USA.
authors: Marie L
authors: ML
authors: Nguyen
authors: John A
authors: JA
authors: Blaho