title: D-penicillamine, a potent melanogenesis inhibitor, lacks any depigmenting effect on black guinea pig skin: the first randomized, evaluator-blinded, vehicle-controlled, in vivo study.
abstract: D-penicillamine is a melanogenesis inhibitor. This in vivo study on ten black guinea pigs using a 5% D-penicillamine ointment showed its lack of any skin-lightening effect. The potential reasons for this ineffectiveness are discussed in the paper, which could be very helpful for researchers exploring new skin-lightening agents.
authors: Shiraz Skin Research Center, Shiraz University of Medical Sciences, Iran.
authors: Maryam
authors: M
authors: Sharifian
authors: Fatemeh
authors: F
authors: Sari-Aslani
authors: Bahram
authors: B
authors: Hemmatinejad
authors: Mohammad K
authors: MK
authors: Fallahzadeh
authors: Behrooz
authors: B
authors: Kasraee
authors: Mohammad
authors: M
authors: J Khoshandish
authors: Ramin
authors: R
authors: Miri
authors: Soleyman
authors: S
authors: Mohammadi-Samani
authors: Farideh
authors: F
authors: Jowkar
authors: Mohammad R
authors: MR
authors: Namazi
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D010396:Penicillamine / Q000494:pharmacology*; D011897:Random Allocation; D012880:Skin Pigmentation / Q000187:drug effects*
chemical_list: D010396:Penicillamine