title: Early results of core decompression and autologous bone marrow mononuclear cells instillation in femoral head osteonecrosis: a randomized control study.
abstract: Fifty-one osteonecrotic hips in 40 patients were randomly divided into 2 treatment groups. Patients in group A (25 hips) were treated with core decompression, and those in group B (26 hips) received autologous bone marrow mononuclear cell instillation into the core tract after core decompression. Outcome between the 2 groups were compared clinically (Harris Hip score), radiographically (x-ray and magnetic resonance imaging), and by Kaplan-Meier hip survival analysis after 12 and 24 months of surgical intervention. The clinical score and mean hip survival were significantly better in group B than in group A (P < .05). Patients with adverse prognostic features at initial presentation, that is, poor Harris Hip score, x-ray changes, edema, and/or effusion on magnetic resonance imaging had significantly better clinical outcome and hip survival in group B than in group A.
authors: Department of Orthopedics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors: Ramesh Kumar
authors: RK
authors: Sen
authors: Sujit Kumar
authors: SK
authors: Tripathy
authors: Sameer
authors: S
authors: Aggarwal
authors: Neelam
authors: N
authors: Marwaha
authors: Ratti Ram
authors: RR
authors: Sharma
authors: Niranjan
authors: N
authors: Khandelwal
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D016026:Bone Marrow Transplantation; D019299:Decompression, Surgical; D005260:Female; D005270:Femur Head / Q000000981:diagnostic imaging / Q000473:pathology; D005271:Femur Head Necrosis / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009000:Monocytes / Q000637:transplantation*; D011379:Prognosis; D011859:Radiography; D033581:Stem Cell Transplantation; D016019:Survival Analysis; D014182:Transplantation, Autologous; D016896:Treatment Outcome