title: A map of local adaptation in Arabidopsis thaliana.
abstract: Local adaptation is critical for species persistence in the face of rapid environmental change, but its genetic basis is not well understood. Growing the model plant Arabidopsis thaliana in field experiments in four sites across the species' native range, we identified candidate loci for local adaptation from a genome-wide association study of lifetime fitness in geographically diverse accessions. Fitness-associated loci exhibited both geographic and climatic signatures of local adaptation. Relative to genomic controls, high-fitness alleles were generally distributed closer to the site where they increased fitness, occupying specific and distinct climate spaces. Independent loci with different molecular functions contributed most strongly to fitness variation in each site. Independent local adaptation by distinct genetic mechanisms may facilitate a flexible evolutionary response to changing environment across a species range.
authors: Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA.
authors: A
authors: A
authors: Fournier-Level
authors: A
authors: A
authors: Korte
authors: M D
authors: MD
authors: Cooper
authors: M
authors: M
authors: Nordborg
authors: J
authors: J
authors: Schmitt
authors: A M
authors: AM
authors: Wilczek
mesh_terms: D000064:Acclimatization; D000222:Adaptation, Physiological; D000483:Alleles; D017360:Arabidopsis / Q000235:genetics* / Q000502:physiology*; D002980:Climate; D005060:Europe; D017343:Genes, Plant; D056084:Genetic Fitness; D056426:Genetic Loci; D018745:Genome, Plant; D055106:Genome-Wide Association Study; D005843:Geography; D020641:Polymorphism, Single Nucleotide; D011485:Protein Binding; D012641:Selection, Genetic; D013696:Temperature; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D014157:Transcription Factors