title: Increased circulating plasma lysophosphatidic acid in patients with acute coronary syndrome.
abstract: BACKGROUND
  The platelet activator lysophosphatidic acid (LPA) has recently been identified as an ingredient in oxidized LDL and it has been isolated from atherosclerotic plaques. The lysophospholipase D activity of autotaxin produces LPA extracellularly from lysophosphatidylcholine (LPC). The present study determines whether circulating LPA is associated with acute coronary syndrome (ACS).
  
  
  METHODS
  We enrolled 141 consecutive patients (age, 62.6±3.8 y; male, 69.2%) with ACS (n=38), stable angina pectoris (SAP; n=72) or angiographically normal coronary arteries (NCA; n=31). The relationships between LPA and other established biomarkers were examined. Concentrations of plasma LPA were determined using an enzymatic assay.
  
  
  RESULTS
  Concentrations of LPA significantly correlated with LPC (r=0.549), autotaxin (r=0.370) and LDL-C (r=0.307) (all p<0.01). Lysophosphatidic acid concentrations were significantly higher in patients with ACS than with SAP and NCA (p<0.01), but did not significantly differ between patients with SAP and NCA. Multivariate logistic regression analyses revealed that the highest LPA tertile was independently associated with ACS (odds ratio 1.99, 95% CI: 1.18-3.39, p=0.02).
  
  
  CONCLUSIONS
  The present study demonstrated that increased circulating plasma LPA concentrations are significantly associated with ACS.
authors: Department of Cardiovascular Medicine, Juntendo University School of Medicine, Tokyo, Japan. tdohi@juntendo.ac.jp
authors: Tomotaka
authors: T
authors: Dohi
authors: Katsumi
authors: K
authors: Miyauchi
authors: Ryunosuke
authors: R
authors: Ohkawa
authors: Kazuhiro
authors: K
authors: Nakamura
authors: Tatsuya
authors: T
authors: Kishimoto
authors: Tadashi
authors: T
authors: Miyazaki
authors: Akihisa
authors: A
authors: Nishino
authors: Naohisa
authors: N
authors: Nakajima
authors: Kenji
authors: K
authors: Yaginuma
authors: Hiroshi
authors: H
authors: Tamura
authors: Takahiko
authors: T
authors: Kojima
authors: Ken
authors: K
authors: Yokoyama
authors: Takeshi
authors: T
authors: Kurata
authors: Kazunori
authors: K
authors: Shimada
authors: Yutaka
authors: Y
authors: Yatomi
authors: Hiroyuki
authors: H
authors: Daida
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood*; D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008246:Lysophospholipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D008246:Lysophospholipids; C032881:lysophosphatidic acid