title: Hormone therapy and coronary heart disease risk by vasomotor menopausal symptoms.
abstract: OBJECTIVE
  We examined whether the association between hormone therapy (HT) use and coronary heart disease (CHD) risk differed between women with and without vasomotor symptoms (VMS).
  
  
  METHODS
  We used data from a Dutch (EPOS) and Swedish (WHILA) population-based sample of 8865 women, aged 46-64 years, and free of CHD, stroke, venous thrombosis/pulmonary embolism or cancer at baseline. Data on HT use, VMS and potential confounders were collected by questionnaires.
  
  
  METHODS
  CHD endpoints, obtained via registries.
  
  
  RESULTS
  252 CHD cases occurred during 10.3 years of follow-up. Neither for women with nor for women without flushing or (night) sweats ever HT use was associated with CHD risk, compared with never HT use. Among women with intense VMS, ever HT use borderline significantly decreased CHD risk compared with never HT use (HR 0.48 [95% CI 0.20-1.03]). Among women without intense VMS, ever HT use was associated with a borderline significant increased CHD risk (HR 1.28 [95% CI 0.96-1.70]; P for interaction=0.02). However, after multivariate adjustment, as compared to never HT use, ever HT use was not associated with risk of CHD among women with or without intense VMS.
  
  
  CONCLUSIONS
  In both groups of women with and without VMS, HT use does not seem to be associated with the risk of CHD. Hence, our findings do not support the view that HT use increases the CHD risk among women with an indication, i.e. VMS, but this needs to be confirmed in specifically designed studies.
authors: Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
authors: Gerrie-Cor M
authors: GC
authors: Gast
authors: Victor J M
authors: VJ
authors: Pop
authors: Göran N
authors: GN
authors: Samsioe
authors: Diederick E
authors: DE
authors: Grobbee
authors: Peter M
authors: PM
authors: Nilsson
authors: Jules J
authors: JJ
authors: Keyzer
authors: Colette J M
authors: CJ
authors: Wijnands-van Gent
authors: Yvonne T
authors: YT
authors: van der Schouw
mesh_terms: D000368:Aged; D003327:Coronary Disease / Q000453:epidemiology* / Q000209:etiology; D015914:Estrogen Replacement Therapy / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D019584:Hot Flashes / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D006945:Hyperhidrosis / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D008593:Menopause; D008875:Middle Aged; D012307:Risk Factors; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D013546:Sweating