title: From synthetic to natural nanoparticles: monitoring the biodegradation of SPIO (P904) into ferritin by electron microscopy.
abstract: A strong focus on Superparamagnetic Iron Oxide Nanoparticles (SPIOs) has been appreciated recently especially for their use in Magnetic Resonance Imaging (MRI). However, some questions are being raised over these particles due to their long-term toxicity related to the production of toxic free iron during their biodegradation. Here we show by Electron Microscopy how SPIOs (P904) (Guerbet, Paris) are degraded after they are taken up by macrophages, so that iron from the SPIO core is progressively incorporated into the iron-storing protein ferritin (a nontoxic form of iron).
authors: Departamento de Ciencia de Materiales e Ingeniería Metalúrgica y Química Inorgánica, Universidad de Cádiz, Campus Río San Pedro, 11510, Cádiz, Spain.
authors: Juan D
authors: JD
authors: López-Castro
authors: Adrian V
authors: AV
authors: Maraloiu
authors: J J
authors: JJ
authors: Delgado
authors: J J
authors: JJ
authors: Calvino
authors: M-G
authors: MG
authors: Blanchin
authors: Natividad
authors: N
authors: Gálvez
authors: José M
authors: JM
authors: Domínguez-Vera
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003911:Dextrans / Q000648:ultrastructure*; D005293:Ferritins / Q000138:chemical synthesis*; D008264:Macrophages / Q000502:physiology* / Q000648:ultrastructure*; D058185:Magnetite Nanoparticles / Q000648:ultrastructure*; D051379:Mice; D008854:Microscopy, Electron; D010587:Phagocytosis / Q000502:physiology*
chemical_list: D003911:Dextrans; D058185:Magnetite Nanoparticles; C097921:ferumoxtran-10; D005293:Ferritins