title: The influence of neighboring group participation on the hydrolysis of 2-O-substituted methyl glucopyranosides.
abstract: Does neighboring group participation actually enhance the reactivity of the anomeric center when the participating group is inherently disarming? To investigate the influence of the neighboring group effect from a 2-O protective group on acidic glycoside hydrolysis, 10 methyl glucosides having different protective groups on O2 have been synthesized and a clear trend between anomeric configuration, participation of the protective group, and the rate of hydrolysis could be observed.
authors: Universitetsparken 5, DK-2100 Copenhagen O, Denmark.
authors: Mads
authors: M
authors: Heuckendorff
authors: Christian M
authors: CM
authors: Pedersen
authors: Mikael
authors: M
authors: Bols