title: Acinetobacter infection--an emerging threat to human health.
abstract: The genus Acinetobacter comprises a complex and heterogeneous group of bacteria, many of which are capable of causing a range of opportunistic, often catheter-related, infections in humans. However, Acinetobacter baumannii, as well as its close relatives belonging to genomic species 3 ("Acinetobacter pittii") and 13TU ("Acinetobacter nosocomialis"), are important nosocomial pathogens, often associated with epidemic outbreaks of infection, that are only rarely found outside of a clinical setting. These organisms are frequently pandrug-resistant and are capable of causing substantial morbidity and mortality in patients with severe underlying disease, both in the hospital and in the community. Several epidemic clonal lineages of A. baumannii have disseminated worldwide and seem to have a selective advantage over non-epidemic strains. The reasons for the success of these epidemic lineages remain to be elucidated, but could be related to the potential of these organisms to achieve very dynamic reorganization and rapid evolution of their genome, including the acquisition and expression of additional antibiotic resistance determinants, under fluctuating environmental and selective conditions.
authors: Department of Biology, University Roma Tre, Rome, Italy. visca@uniroma3.it.
authors: Paolo
authors: P
authors: Visca
authors: Harald
authors: H
authors: Seifert
authors: Kevin J
authors: KJ
authors: Towner
mesh_terms: D000150:Acinetobacter / Q000145:classification* / Q000166:cytology / Q000235:genetics / Q000472:pathogenicity; D000151:Acinetobacter Infections / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D040981:Acinetobacter baumannii / Q000166:cytology / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D021821:Communicable Diseases, Emerging / Q000453:epidemiology*; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D004196:Disease Outbreaks / Q000706:statistics & numerical data*; D014943:Global Health; D006801:Humans; D012307:Risk Factors