title: Indoloquinazoline alkaloids from Euodia rutaecarpa and their cytotoxic activities.
abstract: Nine indoloquinazoline alkaloids (1-9) were isolated from the dried and nearly ripe fruits of Euodia rutaecarpa (Juss.) Benth. (Euodiae Fructus), along with limonin and β-sitosterol. Their structures were elucidated on the basis of their spectroscopic data. Among them, compounds 1 and 2 were new compounds and characterized as (7R,8S)-7-hydroxy-8-methoxy-rutaecarpine and (7R,8S)-7-hydroxy-8-ethoxy-rutaecarpine, respectively, and 1-hydroxy-rutaecarpine (3) and (7R,8S)-7,8-dihydroxy-rutaecarpine (4) were isolated from Euodiae Fructus for the first time. The nine indoloquinazoline alkaloids were evaluated for their cytotoxic activities against human promyelocytic leukemia HL-60 cells and human gastric carcinoma N-87 cells.
authors: State Key Laboratory of Natural and Biomimetic Drugs (Peking University), Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
authors: Xin
authors: X
authors: Huang
authors: You-Bo
authors: YB
authors: Zhang
authors: Xiu-Wei
authors: XW
authors: Yang
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000081005:Cyclohexane Monoterpenes; D004354:Drug Screening Assays, Antitumor; D032086:Evodia / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry; D018922:HL-60 Cells; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification; D019906:Nuclear Magnetic Resonance, Biomolecular; D011799:Quinazolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D012855:Sitosterols / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D000081005:Cyclohexane Monoterpenes; D007211:Indoles; D039821:Monoterpenes; D011799:Quinazolines; D012855:Sitosterols; C028940:limonene-1,2-epoxide; C025473:gamma-sitosterol