title: Developmental outcome after exposure to cyclooxygenase inhibitors during pregnancy and lactation.
abstract: The developmental toxicity of non-selective (ibuprofen, piroxicam, tolmetin) and selective cyclooxygenase-2 inhibitors (DFU) was evaluated in rats. Compounds were administered separately from the eighth gestational to the seventh lactational day. After spontaneous delivery, the weight, length and number of fetuses were determined. The digital radiography and double-staining were used to evaluate the skeleton morphology and mineralization in 7-day-old pups. Maternal toxicity was also assessed. Although decrease in pup weight and length was found, no teratogenic effects were revealed. Decrease in the absolute bone optical density was noted in the groups exposed to the middle and highest doses of tolmetin and ibuprofen, respectively. Increase of the absolute bone density was observed in the groups treated with the middle and the lowest doses of piroxicam, as well as in pups born after the expected day. Non-selective cyclooxygenase inhibitors (non-steroidal anti-inflammatory drugs--NSAID) affected pups growth and influenced mineralization of the lumbar vertebrae.
authors: Department of Human Anatomy, Medical University of Lublin, 4 Jaczewskiego Str., Lublin, Poland. fb3@wp.pl
authors: Franciszek
authors: F
authors: Burdan
authors: Malgorzata
authors: M
authors: Pliszczynska-Steuden
authors: Ingrid
authors: I
authors: Rozylo-Kalinowska
authors: Anna
authors: A
authors: Chalas
authors: T Katarzyna
authors: TK
authors: Rozylo
authors: Elzbieta
authors: E
authors: Staroslawska
authors: Robert
authors: R
authors: Klepacz
authors: Justyna
authors: J
authors: Szumilo
mesh_terms: D000818:Animals; D015519:Bone Density; D001846:Bone Development / Q000187:drug effects*; D001842:Bone and Bones / Q000196:embryology; D002113:Calcification, Physiologic / Q000187:drug effects; D052246:Cyclooxygenase 2 Inhibitors / Q000633:toxicity; D016861:Cyclooxygenase Inhibitors / Q000633:toxicity*; D005260:Female; D047109:Fetal Development / Q000187:drug effects*; D005865:Gestational Age; D007774:Lactation; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors