title: Synthesis of grandisol, the sexual attracting insect pheromone.
abstract: In this issue, Suh's group reported a new formal total synthesis of (±)-grandisol featuring a palladium-catalyzed 4-exo-trig cyclization. Grandisol's interesting cyclobutane structure has been a popular test model for various cyclization methods over the years. This report summarizes Suh's formal synthesis of grandisol along with a concise review of the four-membered ring cyclization strategies employed in the synthesis of grandisol.
authors: Korea Research Institute of Bioscience and Biotechnology, Ochang 363-883, Korea. yskwak@kribb.re.kr
authors: Young-Shin
authors: YS
authors: Kwak
authors: Byeong-Seon
authors: BS
authors: Jeong
mesh_terms: D000818:Animals; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D012724:Sex Attractants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D048889:Weevils
chemical_list: D012724:Sex Attractants; D013729:Terpenes; D010165:Palladium; C013009:grandisol