title: Unrelated cord blood transplantation after myeloablative conditioning regimen in adolescent and young adult patients with hematologic malignancies: a single institute analysis.
abstract: We report the results of unrelated cord blood transplantation (CBT) after myeloablative conditioning regimen in 16 patients with hematologic malignancies from 15 to 20 years old. The median times of myeloid and platelet engraftment were 21 and 38 days, respectively. The cumulative incidences of acute graft-vs-host disease (GVHD) was 62.0%, all of which were grade I or II, and that of extensive-type chronic GVHD was 12.5%. The probabilities of overall and disease-free survival at 3 years were 68.2% and 48.6%, respectively, comparable to adult or childhood cases. Adolescents and young adult patients with hematologic malignancies who have no HLA-matched adult donors could be considered as candidates for CBT.
authors: Department of Pediatric Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. ebihara@ims.u-tokyo.ac.jp
authors: Yasuhiro
authors: Y
authors: Ebihara
authors: Satoshi
authors: S
authors: Takahashi
authors: Shinji
authors: S
authors: Mochizuki
authors: Seiko
authors: S
authors: Kato
authors: Toshiro
authors: T
authors: Kawakita
authors: Jun
authors: J
authors: Ooi
authors: Kazuaki
authors: K
authors: Yokoyama
authors: Fumitaka
authors: F
authors: Nagamura
authors: Arinobu
authors: A
authors: Tojo
authors: Shigetaka
authors: S
authors: Asano
authors: Kohichiro
authors: K
authors: Tsuji
mesh_terms: D000293:Adolescent; D000328:Adult; D036101:Cord Blood Stem Cell Transplantation; D018572:Disease-Free Survival; D005260:Female; D006086:Graft vs Host Disease / Q000517:prevention & control; D019337:Hematologic Neoplasms / Q000097:blood / Q000401:mortality / Q000628:therapy*; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D015996:Survival Rate; D014019:Tissue Donors; D019172:Transplantation Conditioning; D055815:Young Adult