title: The rgg0182 gene encodes a transcriptional regulator required for the full Streptococcus thermophilus LMG18311 thermal adaptation.
abstract: BACKGROUND
  Streptococcus thermophilus is an important starter strain for the production of yogurt and cheeses. The analysis of sequenced genomes of four strains of S. thermophilus indicates that they contain several genes of the rgg familly potentially encoding transcriptional regulators. Some of the Rgg proteins are known to be involved in bacterial stress adaptation.
  
  
  RESULTS
  In this study, we demonstrated that Streptococcus thermophilus thermal stress adaptation required the rgg0182 gene which transcription depends on the culture medium and the growth temperature. This gene encoded a protein showing similarity with members of the Rgg family transcriptional regulator. Our data confirmed that Rgg0182 is a transcriptional regulator controlling the expression of its neighboring genes as well as chaperones and proteases encoding genes. Therefore, analysis of a Δrgg0182 mutant revealed that this protein played a role in the heat shock adaptation of Streptococcus thermophilus LMG18311.
  
  
  CONCLUSIONS
  These data showed the importance of the Rgg0182 transcriptional regulator on the survival of S. thermophilus during dairy processes and more specifically during changes in temperature.
authors: INRA, UMR1128 Génétique et Microbiologie, F-54506 Vandœuvre-lès-Nancy Cedex, France.
authors: Romain
authors: R
authors: Henry
authors: Emmanuelle
authors: E
authors: Bruneau
authors: Rozenn
authors: R
authors: Gardan
authors: Stéphane
authors: S
authors: Bertin
authors: Betty
authors: B
authors: Fleuchot
authors: Bernard
authors: B
authors: Decaris
authors: Nathalie
authors: N
authors: Leblond-Bourget
mesh_terms: D000222:Adaptation, Physiological; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D006358:Hot Temperature; D008969:Molecular Sequence Data; D048249:Streptococcus thermophilus / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D014157:Transcription Factors