title: A convergent strategy for the synthesis of polycyclic ethers by using oxiranyl anions.
abstract: A new [X+2+Y]-type for the convergent synthesis of polycyclic ethers based on an oxiranyl anion strategy was developed. The sequence involves nucleophilic substitution of a triflate with an oxiranyl anion followed by 6-endo cyclization, ring expansion, and reductive etherification. The protocol features a flexible approach toward trans-fused polycyclic arrays consisting of six- and seven-membered ether rings from the same starting materials.
authors: Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Nagoya 468-8503, Japan.
authors: Takeo
authors: T
authors: Sakai
authors: Ai
authors: A
authors: Sugimoto
authors: Yuji
authors: Y
authors: Mori
mesh_terms: D000838:Anions / Q000737:chemistry; D003500:Cyclization; D004987:Ethers / Q000138:chemical synthesis*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D008745:Methylation; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry*
chemical_list: D000838:Anions; D004987:Ethers; D006571:Heterocyclic Compounds; D010100:Oxygen