title: Serum adiponectin levels are significantly reduced during the second half of normal pregnancy.
abstract: OBJECTIVE
  To demonstrate the physiologic changes in adiponectin levels during the first vs second half of pregnancy.
  
  
  METHODS
  Sixty-six females with uncomplicated pregnancies and normal pre-gestational BMI had serum adiponectin levels obtained at various gestational ages. Thirty-one samples were obtained during the first half of their pregnancy vs 35 in the second half. Thirty-three healthy non-pregnant females with comparable ages and BMI were controls.
  
  
  RESULTS
  Mean adiponectin levels were 9.55 microg/dl (95% CI 8.2-10.77) vs 9.48 microg/dl (95% CI 8.44-10.66) in the control group in the first half of pregnancy (p = NS). We noted a 21% reduction in mean adiponectin levels (7.51 microg/dl) during the second half of pregnancy (p = 0.03) compared to the first half of pregnancy.
  
  
  CONCLUSIONS
  Early pregnancy does not affect adiponectin levels. However, there is a significant reduction in adiponectin levels during the second half of pregnancy.
authors: The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ, USA.
authors: H
authors: H
authors: Elshoreya
authors: F
authors: F
authors: Steinberg
authors: R
authors: R
authors: Perry
authors: C
authors: C
authors: Hansen
authors: B
authors: B
authors: Milcareck
authors: S
authors: S
authors: Elkouachi
authors: J H
authors: JH
authors: Check
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy / Q000097:blood*; D055815:Young Adult
chemical_list: D052242:Adiponectin