title: Magnetic silyl scaffold enables efficient recycling of protecting groups.
abstract: A novel organic/inorganic hybrid material comprising carboncoated cobalt nanoparticles and a poly(benzylchloride)styrene shell is the first magnetic support that complies with important requirements for immobilized reagents and scavengers, that is, stability under harsh conditions (e.g., acids), sufficient loading (up to 2 mmol g(-1)), and satisfying magnetization. The durability of the scaffold was demonstrated by immobilization of a trialkylsilane reagent, which served as a "magnetic" protecting group for a number of primary and secondary alcohols. Importantly, the scaffold could be efficiently separated, recycled, and reused after alcohol cleavage (HF·pyridine) via regeneration of the silyl chloride moiety with BCl(3).
authors: Institute for Chemical and Bioengineering, ETH Zürich, Switzerland.
authors: Alexander
authors: A
authors: Schaetz
authors: Martin
authors: M
authors: Zeltner
authors: Thomas D
authors: TD
authors: Michl
authors: Michael
authors: M
authors: Rossier
authors: Roland
authors: R
authors: Fuhrer
authors: Wendelin J
authors: WJ
authors: Stark