title: Design and synthesis of triazolopyridazines substituted with methylisoquinolinone as selective c-Met kinase inhibitors.
abstract: A series of triazolopyridazines substituted with methylisoquinolinone were designed and synthesized. Some of the triazolopyridazines strongly inhibited c-Met kinase and showed good anti-proliferative activity against a panel of c-Met-amplified gastric cancer cell lines (MKN-45, SNU-5 and Hs746T).
authors: Bio-Organic Science Division, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.
authors: Jae Wook
authors: JW
authors: Ryu
authors: Sun-Young
authors: SY
authors: Han
authors: Jeong In
authors: JI
authors: Yun
authors: Sang-Un
authors: SU
authors: Choi
authors: Heejung
authors: H
authors: Jung
authors: Jae Du
authors: JD
authors: Ha
authors: Sung Yun
authors: SY
authors: Cho
authors: Chong Ock
authors: CO
authors: Lee
authors: Nam Sook
authors: NS
authors: Kang
authors: Jong Sung
authors: JS
authors: Koh
authors: Hyoung Rae
authors: HR
authors: Kim
authors: Jongkook
authors: J
authors: Lee
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D015195:Drug Design; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008958:Models, Molecular; D015394:Molecular Structure; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D019859:Proto-Oncogene Proteins c-met / Q000037:antagonists & inhibitors*; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013274:Stomach Neoplasms / Q000188:drug therapy*; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D007546:Isoquinolines; D047428:Protein Kinase Inhibitors; D011724:Pyridazines; D014230:Triazoles; D019859:Proto-Oncogene Proteins c-met