title: [Effects of β-lactam antibiotics ceftriaxone on expression of glutamate in hippocampus after traumatic brain injury in rats].
abstract: To investigate the effect of β-lactam antibiotics ceftriaxone on the levels of glutamate in hippocampus following traumatic brain injury in rat.
  
  
  
  Rats were divided randomly into three groups:sham group; trauma group and trauma+ceftriaxone group. Rats in the later two groups were subjected to a lateral cortical impact injury caused by a free-falling object, and trauma+ceftriaxone group was treated with ceftriaxone immediately after injury. The levels of glutamate in hippocampus was determined by HPLC at 12 h after trauma; the pathological change at 24 h after trauma was examined and water content of brain tissue at 3, 12 and 24 h after trauma was measured in three groups.
  
  
  
  Compared with the trauma group,the water content in brain tissue (P<0.05), neuronal death in hippocampus CAl area and the levels of glutamate and aspartate in hippocampus at 12 h (P<0.05) were significantly decreased in trauma+ceftriaxone group.
  
  
  
  β-lactam antibiotics ceftriaxone can reduce the level of brain glutamate, brain edema and neuronal death after traumatic brain injury in rat.
authors: Lin'an Hospital of Traditional Chinese Medicine, Lin'an, China.
authors: Xiang-dong
authors: XD
authors: Pan
authors: Jing
authors: J
authors: Wei
authors: Guo-min
authors: GM
authors: Xiao
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000378:metabolism* / Q000473:pathology; D002443:Ceftriaxone / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D018698:Glutamic Acid; D002443:Ceftriaxone