title: Design, synthesis and antifungal activity of some new imidazole and triazole derivatives.
abstract: Triazole and imidazole are incorporated into the structures of many antifungal compounds. In this study a novel series of 1,2,4-triazole, imidazole, benzoimidazole, and benzotriazole derivatives was designed as inhibitors of cytochrome P450 14α-demethylase (14DM). These structures were docked into the active site of MT-CYP51, using Autodock program. Sixteen compounds with the best binding energy were synthesized. The chemical structures of the new compounds were confirmed by elemental and spectral ((1) H-NMR and Mass) analyses. All compounds were investigated for antifungal activity against Candida albicans, Candida tropicalis, Candida glabrata, Candida parapeilosis, Candida kruzei, Candida dubliniensis, Aspergillus fomigatus, Aspergillus flavus, Microsporum canis, Microsporum gypseum, Trichophyton mentagrophyte, Epidermophyton floccosum. Some compounds showed excellent in-vitro antifungal activity against most of the tested fungi. Compounds 2, 9, and 10 had antifungal activity against several resistant fungi against fluconazole and itraconazole.
authors: Department of Medicinal Chemistry, Shiraz University of Medical Sciences, Iran. rezaeiza@sums.ac.ir
authors: Zahra
authors: Z
authors: Rezaei
authors: Soghra
authors: S
authors: Khabnadideh
authors: Kamiar
authors: K
authors: Zomorodian
authors: Kyvan
authors: K
authors: Pakshir
authors: Giti
authors: G
authors: Kashi
authors: Narges
authors: N
authors: Sanagoei
authors: Sanaz
authors: S
authors: Gholami
mesh_terms: D058888:14-alpha Demethylase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D005658:Fungi / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development; D007093:Imidazoles / Q000737:chemistry*; D008024:Ligands; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011485:Protein Binding; D058886:Sterol 14-Demethylase / Q000378:metabolism; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000737:chemistry*
chemical_list: D058888:14-alpha Demethylase Inhibitors; D000935:Antifungal Agents; D007093:Imidazoles; D008024:Ligands; D014230:Triazoles; C029899:imidazole; D058886:Sterol 14-Demethylase