title: (WO2011057959) indole and indazole derivatives as glycogen synthase activators: a patent evaluation.
abstract: Scientific evaluation of a patent aiming for the development of indole and indazole derivatives from biaryloxymethylarene as glycogen synthase activators, a key enzyme involved in type 2 diabetes mellitus.
authors: University of Athens, Department of Pharmacy and Natural Products Chemistry, Panepistimiopolis Zografou, GR-15771 Athens, Greece. skaltsounis@pharm.uoa.gr
authors: Alexios-Leandros
authors: AL
authors: Skaltsounis
authors: Nicolas
authors: N
authors: Gaboriaud-Kolar
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000201:enzymology; D015195:Drug Design; D004789:Enzyme Activation; D020536:Enzyme Activators / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006006:Glycogen Synthase / Q000378:metabolism*; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D007191:Indazoles / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D015394:Molecular Structure; D010330:Patents as Topic; D013329:Structure-Activity Relationship
chemical_list: D020536:Enzyme Activators; D007004:Hypoglycemic Agents; D007191:Indazoles; D007211:Indoles; D006006:Glycogen Synthase