title: Clinical and dimensional characteristics of euthymic bipolar patients with or without suicidal behavior.
abstract: BACKGROUND
  The clinical and dimensional features associated with suicidal behaviour in bipolar patients during euthymic states are not well characterised.
  
  
  METHODS
  In a sample of 652 euthymic bipolar patients, we assessed clinical features with the Diagnostic Interview for Genetics Studies (DIGS) and dimensional characteristics with questionnaires measuring impulsivity/hostility and affective lability/intensity. Bipolar patients with and without suicidal behaviour were compared for these clinical and dimensional variables.
  
  
  RESULTS
  Of the 652 subjects, 42.9% had experienced at least one suicide attempt. Lifetime history of suicidal behaviour was associated with being a woman, a history of head injury, tobacco misuse and indicators of severity of bipolar disorder including early age at onset, high number of depressive episodes, positive history of rapid cycling, alcohol misuse and social phobia. Indirect hostility and irritability were dimensional characteristics associated with suicidal behaviour in bipolar patients, whereas impulsivity and affective lability/intensity were not associated with suicidal behaviour.
  
  
  CONCLUSIONS
  This study had a retrospective design with no replication sample.
  
  
  CONCLUSIONS
  Bipolar patients with earlier onset, mood instability (large number of depressive episodes, rapid cycling) and/or particular addictive and anxiety comorbid disorders might be at high risk of suicidal behaviour. In addition, hostility dimensions (indirect hostility and irritability), may be trait components associated with suicidal behaviour in euthymic bipolar patients.
authors: AP-HP, groupe Henri-Mondor-Albert-Chenevier, pôle de psychiatrie, 94000 Créteil, France. claire.sanz-parmentier@hmn.aphp.fr
authors: C
authors: C
authors: Parmentier
authors: B
authors: B
authors: Etain
authors: L
authors: L
authors: Yon
authors: H
authors: H
authors: Misson
authors: F
authors: F
authors: Mathieu
authors: M
authors: M
authors: Lajnef
authors: B
authors: B
authors: Cochet
authors: A
authors: A
authors: Raust
authors: J P
authors: JP
authors: Kahn
authors: O
authors: O
authors: Wajsbrot-Elgrabli
authors: R
authors: R
authors: Cohen
authors: C
authors: C
authors: Henry
authors: M
authors: M
authors: Leboyer
authors: F
authors: F
authors: Bellivier
mesh_terms: D000328:Adult; D003527:Cyclothymic Disorder / Q000453:epidemiology / Q000503:physiopathology* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D013406:Suicide, Attempted / Q000523:psychology*