title: Wall shear stress distribution inside growing cerebral aneurysm.
abstract: OBJECTIVE
  Hemodynamic stimulation has been suggested to affect the growth of cerebral aneurysms. The present study examined the effects of intra-aneurysmal hemodynamics on aneurysm growth.
  
  
  METHODS
  Velocity profiles were measured for 2 cases of AcomA aneurysms. Realistically shaped models of these aneurysms were constructed, based on CT angiograms. Flow fields and WSS in the models were measured by using particle image velocimetry and LDV. In 1 case, hemodynamic changes were observed in 4 stages of growth over a 27-month period, whereas no development was observed in the other case.
  
  
  RESULTS
  The growing model had a smaller and more stagnant recirculation area than that in the nongrowth model. The WSS was markedly reduced in the enlarging region in the growing models, whereas extremely low WSS was not found in the nongrowth model. In addition, a higher WSSG was consistently observed adjacent to the enlarging region during aneurysm growth.
  
  
  CONCLUSIONS
  The results indicated that the flow structure of recirculation itself does not necessarily lead to high likelihood of cerebral aneurysm. However, WSSG and WSS were distinctly different between the 2 cases. Higher WSSG was found surrounding the growing region, and extremely low WSS was found at the growing region of the growing cerebral aneurysm.
authors: Department of System Design Engineering, Keio University Faculty of Science and Technology, Yokohama, Japan. moonlight_game@diamond.broba.cc
authors: T
authors: T
authors: Tanoue
authors: S
authors: S
authors: Tateshima
authors: J P
authors: JP
authors: Villablanca
authors: F
authors: F
authors: Viñuela
authors: K
authors: K
authors: Tanishita
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology; D002533:Cerebral Angiography; D002536:Cerebral Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D018450:Disease Progression; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000503:physiopathology*; D008953:Models, Anatomic; D008955:Models, Cardiovascular; D012031:Refractometry; D012307:Risk Factors; D033081:Shear Strength / Q000502:physiology*; D012828:Silicones; D013314:Stress, Mechanical; D014057:Tomography, X-Ray Computed
chemical_list: D012828:Silicones