title: The effects of olibanum administered to methimazole-treated dams during lactation on learning and memory of offspring rats.
abstract: The effect of olibanum administered during lactation to methimazole-treated dams on the learning of offspring was evaluated. The animals were treated for 60 days from the first day of lactation period: group 1--tap water, group 2-0.03% methimazole and groups 3 and 4-0.03% methimazole with 0.25% or 0.125% olibanum, respectively. The serum thyroxin level in the offspring of group 2 was significantly lower than that of group 1. However, there was no difference compared to groups 3 and 4. In a Morris water maze, the distance and time latency to reach the platform in offspring of group 2 was significantly higher than groups 1, 3 and 4. In probe trial, the time spent in target quadrant (Q₁) by offspring of group 2 was lower than groups 1, 3 and 4. It is suggested that impaired learning and memory in the offspring of hypothyroid rats may be prevented by olibanum.
authors: Neuroscience Research Center, University of Medical Sciences-MUMS, Mashhad, Iran. hosseinim@MUMS.ac.ir
authors: Mahmoud
authors: M
authors: Hosseini
authors: Mohammad Naser
authors: MN
authors: Shafei
authors: Vajiheh
authors: V
authors: Safari
authors: Zahra
authors: Z
authors: Taiarani
authors: Marzieh
authors: M
authors: Kafami Ladani
authors: Reihaneh
authors: R
authors: Sadeghian
mesh_terms: D000818:Animals; D029743:Boswellia / Q000737:chemistry*; D005260:Female; D007774:Lactation / Q000187:drug effects; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D008713:Methimazole / Q000494:pharmacology*; D028321:Plant Preparations / Q000627:therapeutic use*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000188:drug therapy; D051381:Rats
chemical_list: D028321:Plant Preparations; D008713:Methimazole