title: AdipoR1 and 2 are expressed on warm sensitive neurons of the hypothalamic preoptic area and contribute to central hyperthermic effects of adiponectin.
abstract: Adiponectin can act in the brain to increase energy expenditure and reduce body weight by mechanisms not entirely understood. We found that adiponectin type 1 and type 2 receptors (AdipoR1 and AdipoR2) are expressed in warm sensitive neurons of the hypothalamic preoptic area (POA) which play a critical role in the regulation of core body temperature (CBT) and energy balance. Thus, we tested the ability of adiponectin to influence CBT in wild-type mice and in mice deficient for AdipoR1 or AdipoR2. Local injection of adiponectin into the POA induced prolonged elevation of core body temperature and decreased respiratory exchange ratio (RER) indicating that increased energy expenditure is associated with increased oxidation of fat over carbohydrates. In AdipoR1 deficient mice, the ability of adiponectin to raise CBT was significantly blunted and its ability to decrease RER was completely lost. In AdipoR2 deficient mice, adiponectin had only diminished hyperthermic effects but reduced RER similarly to wild type mice. These results indicate that adiponectin can contribute to energy homeostasis by regulating CBT by direct actions on AdipoR1 and R2 in the POA.
authors: Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, La Jolla, CA 92037, USA.
authors: Izabella
authors: I
authors: Klein
authors: Manuel
authors: M
authors: Sanchez-Alavez
authors: Iustin
authors: I
authors: Tabarean
authors: Jean
authors: J
authors: Schaefer
authors: Kristina H
authors: KH
authors: Holmberg
authors: Joe
authors: J
authors: Klaus
authors: Fengcheng
authors: F
authors: Xia
authors: Maria Cecilia Garibaldi
authors: MC
authors: Marcondes
authors: Jeffrey S
authors: JS
authors: Dubins
authors: Brad
authors: B
authors: Morrison
authors: Viktor
authors: V
authors: Zhukov
authors: Alejandro
authors: A
authors: Sanchez-Gonzalez
authors: Kayo
authors: K
authors: Mitsukawa
authors: John R
authors: JR
authors: Hadcock
authors: Tamas
authors: T
authors: Bartfai
authors: Bruno
authors: B
authors: Conti
mesh_terms: D052242:Adiponectin / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D002153:Calorimetry, Indirect; D004734:Energy Metabolism / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects / Q000235:genetics; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011301:Preoptic Area / Q000166:cytology*; D054419:Receptors, Adiponectin / Q000172:deficiency / Q000378:metabolism*; D011984:Sensory Receptor Cells / Q000187:drug effects / Q000502:physiology*; D013686:Telemetry; D013697:Thermosensing / Q000187:drug effects / Q000502:physiology
chemical_list: D052242:Adiponectin; D054419:Receptors, Adiponectin; C504339:adiponectin receptor 1, rat; C475421:adiponectin receptor 2, mouse