title: Acetylcholinesterase inhibition activity of acetylated depsidones from Lobaria pulmonaria.
abstract: As part of our ongoing project of new acetylcholinesterase inhibitors from lower marine and terrestrial species, a phytochemical investigation was conducted on a foliose lichen, Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), from Bosnia and Herzegovina. The study led to the isolation of a mixture of acetylated depsidones which showed a moderate activity (0.5 µg) in the acetylcholinesterase inhibition test on Thin-layer chromatography plate. Our results indicate for the first time the significance of depsidones, highly specific metabolites from lichen species, in searching for these inhibitors which still represent the best drugs currently available for the management of Alzheimer's disease.
authors: Department of Organic Chemistry, Faculty of Chemistry, University of Belgrade, Serbia. borispejin@yahoo.com
authors: Boris
authors: B
authors: Pejin
authors: Giuseppina
authors: G
authors: Tommonaro
authors: Carmine
authors: C
authors: Iodice
authors: Vele
authors: V
authors: Tesevic
authors: Vlatka
authors: V
authors: Vajs
mesh_terms: D000107:Acetylation; D000110:Acetylcholinesterase / Q000378:metabolism*; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D053630:Depsides / Q000737:chemistry* / Q000494:pharmacology*; D007783:Lactones / Q000737:chemistry* / Q000494:pharmacology*; D008011:Lichens / Q000737:chemistry*
chemical_list: D002800:Cholinesterase Inhibitors; D053630:Depsides; D007783:Lactones; C000875:depsidone; D000110:Acetylcholinesterase