title: Pathogenesis and disease mechanisms of occupational asthma.
abstract: Occupational asthma (OA) is one of the most common forms of work-related lung disease in all industrialized nations. The clinical management of patients with OA depends on an understanding of the multifactorial pathogenetic mechanisms that can contribute to this disease. This article discusses the various immunologic and nonimmunologic mechanisms and genetic susceptibility factors that drive the inflammatory processes of OA.
authors: Department of Internal Medicine, University of Cincinnati College of Medicine, 3255 Eden Avenue, Cincinnati, OH 45267-0563, USA.
authors: Zana L
authors: ZL
authors: Lummus
authors: Adam V
authors: AV
authors: Wisnewski
authors: David I
authors: DI
authors: Bernstein
mesh_terms: D056151:Airway Remodeling / Q000276:immunology; D000485:Allergens / Q000009:adverse effects* / Q000276:immunology; D059366:Asthma, Occupational / Q000145:classification / Q000209:etiology / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity / Q000209:etiology / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007113:Immunity, Innate; D007073:Immunoglobulin E / Q000276:immunology*; D007509:Irritants / Q000009:adverse effects* / Q000276:immunology; D016273:Occupational Exposure / Q000517:prevention & control; D018384:Oxidative Stress; D012307:Risk Factors
chemical_list: D000485:Allergens; D007509:Irritants; D007073:Immunoglobulin E