title: Reduction of erosive wear in situ by stannous fluoride-containing toothpaste.
abstract: OBJECTIVE
  Stannous fluoride (SnF) has been suggested as a dental erosion-preventive agent. The aim of this single-centre, randomized, double-blind, in situ study was to evaluate the effect of toothpastes with SnF in the prevention of erosive enamel wear.
  
  
  METHODS
  A combined split-mouth (extra-oral water or toothpaste brushing) and crossover (type of toothpaste) set-up was used. Twelve volunteers wore palatal appliances containing human enamel samples. Three toothpastes were used, in three consecutive runs, in randomized order: two toothpastes containing SnF (coded M and PE) and one toothpaste containing only sodium fluoride (coded C). On day 1 of each run the appliances were worn for pellicle formation. On days 2-5 the samples were also brushed twice with a toothpaste-water slurry or only water (control). Erosion took place on days 2-5 extra-orally 3 times a day (5 min) in a citric acid solution (pH 2.3). Enamel wear depth was quantified by optical profilometry. The effect of toothpastes was tested using General Linear Modeling.
  
  
  RESULTS
  Average erosive wear depth of control samples was 23 μm. Both SnF toothpastes significantly reduced erosive wear: M by 34% (SD 39%) and PE by 26% (SD 25%). The control toothpaste reduced erosive wear non-significantly by 7% (SD 20%). Both SnF-containing toothpastes significantly reduced erosive wear compared to the sodium fluoride toothpaste.
  
  
  CONCLUSIONS
  We conclude that SnF-containing toothpastes are able to reduce erosive tooth wear in situ.
authors: College of Dental Science, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. m.c.d.n.j.m.huysmans@dent.umcn.nl
authors: M C D N J M
authors: MC
authors: Huysmans
authors: D H J
authors: DH
authors: Jager
authors: J L
authors: JL
authors: Ruben
authors: D E M F
authors: DE
authors: Unk
authors: C P A H
authors: CP
authors: Klijn
authors: A M
authors: AM
authors: Vieira
mesh_terms: D000328:Adult; D019343:Citric Acid / Q000494:pharmacology; D018592:Cross-Over Studies; D003743:Dental Enamel / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D012969:Sodium Fluoride / Q000627:therapeutic use; D018709:Statistics, Nonparametric; D014002:Tin Fluorides / Q000627:therapeutic use*; D014077:Tooth Erosion / Q000517:prevention & control*; D014100:Toothpastes / Q000737:chemistry / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D014002:Tin Fluorides; D014100:Toothpastes; D019343:Citric Acid; D012969:Sodium Fluoride