title: Primary B cell repertoire remodeling to achieve humoral transplantation tolerance.
abstract: The current mainstay of immunotherapy in clinical transplantation is T lymphocyte directed. However, it has long been appreciated that the emergence of an alloimmune response mounted by the B lymphocyte compartment and detectable as donor-specific antibodies is a critical challenge to long-term graft survival. Thus, achieving robust transplantation tolerance will require induction of tolerance in both the T- and B-cell compartments. Here we propose that the natural developmental propensity of the B-lymphocyte compartment acquisition of tolerance to self-antigens can be recapitulated to achieve humoral transplantation tolerance. It is our contention B-lymphocyte directed induction immunotherapy would be an important component of emerging strategies for induction of Transplantation tolerance.
authors: Harrison Department of Surgical Research, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
authors: Ronald F
authors: RF
authors: Parsons
authors: Robert R
authors: RR
authors: Redfield
authors: Eduardo
authors: E
authors: Rodriguez
authors: Moiz M
authors: MM
authors: Mustafa
authors: Kumar
authors: K
authors: Vivek
authors: Michael
authors: M
authors: Murayama
authors: Ali
authors: A
authors: Naji
authors: Hooman
authors: H
authors: Noorchashm
mesh_terms: D000818:Animals; D053264:B-Cell Activating Factor / Q000378:metabolism*; D016175:B-Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology / Q000637:transplantation; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D007518:Isoantibodies / Q000096:biosynthesis* / Q000276:immunology; D007519:Isoantigens / Q000276:immunology*; D008212:Lymphocyte Depletion / Q000379:methods; D023001:Transplantation Tolerance / Q000276:immunology*
chemical_list: D053264:B-Cell Activating Factor; D007518:Isoantibodies; D007519:Isoantigens