title: Bacterial inactivation using silver-coated magnetic nanoparticles as functional antimicrobial agents.
abstract: The ability for silver nanoparticles to function as an antibacterial agent while being separable from the target fluids is important for bacterial inactivation in biological fluids. This report describes the analysis of the antimicrobial activities of silver-coated magnetic nanoparticles synthesized by wet chemical methods. The bacterial inactivation of several types of bacteria was analyzed, including Gram-positive bacteria ( Staphylococcus aureus  and  Bacillus cereus ) and Gram-negative bacteria ( Pseudomonas aeruginosa ,  Enterobacter cloacae , and  Escherichia coli ). The results have demonstrated the viability of the silver-coated magnetic nanoparticles for achieving effective bacterial inactivation efficiency comparable to and better than that of silver nanoparticles conventionally used. The bacteria inactivation efficiency of our silver-coated MnZn ferrite (MZF@Ag) nanoparticles was also determined for blood platelets samples, demonstrating the potential of utilization in inactivating bacterial growth in platelets prior to transfusion to ensure blood product safety, which also has important implications for enabling the capability of effective separation, delivery, and targeting of the antibacterial agents.
authors: Department of Chemistry, State University of New York at Binghamton, Binghamton, New York 13902, United States.
authors: Lingyan
authors: L
authors: Wang
authors: Jin
authors: J
authors: Luo
authors: Shiyao
authors: S
authors: Shan
authors: Elizabeth
authors: E
authors: Crew
authors: Jun
authors: J
authors: Yin
authors: Chuan-Jian
authors: CJ
authors: Zhong
authors: Brandi
authors: B
authors: Wallek
authors: Season S S
authors: SS
authors: Wong
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008280:Magnetics; D053768:Metal Nanoparticles / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D012834:Silver / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D012834:Silver