title: Iodide-catalyzed reductions: development of a synthesis of phenylacetic acids.
abstract: A new convenient and scalable synthesis of phenylacetic acids has been developed via the iodide catalyzed reduction of mandelic acids. The procedure relies on in situ generation of hydroiodic acid from catalytic sodium iodide, employing phosphorus acid as the stoichiometric reductant.
authors: Chemical Process Research and Development, Amgen Inc., Thousand Oaks, California 91320, USA. milne@amgen.com
authors: Jacqueline E
authors: JE
authors: Milne
authors: Thomas
authors: T
authors: Storz
authors: John T
authors: JT
authors: Colyer
authors: Oliver R
authors: OR
authors: Thiel
authors: Mina
authors: M
authors: Dilmeghani Seran
authors: Robert D
authors: RD
authors: Larsen
authors: Jerry A
authors: JA
authors: Murry
mesh_terms: D000143:Acids / Q000737:chemistry; D002384:Catalysis; D007454:Iodides / Q000737:chemistry*; D017613:Iodine Compounds / Q000737:chemistry; D008333:Mandelic Acids / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010648:Phenylacetates / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000143:Acids; D007454:Iodides; D017613:Iodine Compounds; D008333:Mandelic Acids; D010648:Phenylacetates; C010466:hydroiodic acid; C025136:phenylacetic acid