title: Synthesis, antimicrobial activity and cytotoxicity of some new carbazole derivatives.
abstract: In this work, some N-(9-Ethyl-9H-carbazole-3-yl)-2-(phenoxy)acetamide derivatives were synthesised and evaluated for their antimicrobial activity and cytotoxicity. The structural elucidation of the compounds was performed by IR, (1)H-NMR, (13)C-NMR and FAB(+)-MS spectral data and elemental analyses. The title compounds were obtained by reacting 2-chloro-N-(9-ethyl-9H-carbazole-3-yl)acetamide with some substituted phenols. The synthesised compounds were investigated for their antibacterial and antifungal activities against Micrococcus luteus, Bacillus subtilis, Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Listeria monocytogenes and Candida albicans. The compounds N-(9-Ethyl-9H-carbazole-3-yl)-2-(4-ethylphenoxy)acetamide (2c) and N-(9-Ethyl-9H-carbazole-3-yl)-2-(quinolin-8-yloxy)acetamide (2n) showed notable antimicrobial activity. The compounds were also studied for their cytotoxic effects using MTT assay, and it was seen that 2n had the lowest cytotoxic activity against NIH/3T3 cells.
authors: Department of Pharmaceutical Chemistry, Anadolu University, Eskişehir, Turkey. zakaplan@anadolu.edu.tr
authors: Zafer Asim
authors: ZA
authors: Kaplancikli
authors: Leyla
authors: L
authors: Yurttaş
authors: Gülhan
authors: G
authors: Turan-Zitouni
authors: Ahmet
authors: A
authors: Özdemir
authors: Rasime
authors: R
authors: Özic
authors: Şafak
authors: Ş
authors: Ulusoylar-Yildirim
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D002227:Carbazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000254:growth & development; D051379:Mice; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D041681:NIH 3T3 Cells
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D002227:Carbazoles