title: Functional human to mouse adipose tissue xenotransplantation.
abstract: White adipose tissue (WAT) produces a number of metabolically important factors and, therefore, some inborn errors of metabolism may potentially be corrected by transplantation of normal allogeneic WAT. To explore the ability of human WAT (HuWAT) to compensate for a missing factor and to induce allogeneic immune response, we created leptin-deficient, immunodeficient mice and transplanted them with either 2·5 or 5 ml HuWAT. Recipient mice showed stable levels of human leptin in circulation, reduced body mass gain, and amelioration of hepatic steatosis. Food consumption and plasma insulin levels were reduced only in recipients of 5 ml WAT. Transfer of 2×10(7) human mononuclear cells to reject WAT as an allograft was ineffective and resulted only in some reduction of circulating leptin and a limited damage to the WAT grafts followed by the loss of human leukocytes.
authors: Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA. vitaly.ablamunits@yale.edu
authors: Vitaly
authors: V
authors: Ablamunits
authors: Simon
authors: S
authors: Klebanov
authors: Sharon Y
authors: SY
authors: Giese
authors: Kevan C
authors: KC
authors: Herold
mesh_terms: D052436:Adipose Tissue, White / Q000637:transplantation*; D000818:Animals; D005234:Fatty Liver / Q000473:pathology / Q000628:therapy; D006084:Graft Rejection / Q000276:immunology; D006801:Humans; D020738:Leptin / Q000097:blood / Q000172:deficiency; D008099:Liver / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008820:Mice, Obese; D014183:Transplantation, Heterologous
chemical_list: D020738:Leptin