title: Treatment of rabies in the 21st century: curing the incurable?
abstract: Despite the extreme case fatality attributable to rabies, reports of survivors provide a faint glimpse of a possibility of overcoming this deadly disease, even after clinical symptoms manifest. At present, no existing approach fulfills modern medical criteria for the optimal therapy of rabies. Until new efficacious antiviral compounds and optimized treatment protocols are developed, animal population management and vaccination of major reservoirs and vectors, minimization of the risk of viral exposures, and appropriate and early postexposure prophylaxis, remain the hallmarks of modern public health intervention.
authors: Centers for Disease Control & Prevention, Division of High-Consequence Pathogens & Pathology, 1600 Clifton Road, MS G33, GA 30333, USA.
authors: Richard
authors: R
authors: Franka
authors: Charles E
authors: CE
authors: Rupprecht
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003140:Communicable Disease Control / Q000639:trends*; D019468:Disease Management; D049674:History, 21st Century; D006801:Humans; D056990:Post-Exposure Prophylaxis; D011634:Public Health / Q000639:trends; D011818:Rabies / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control / Q000628:therapy*; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000627:therapeutic use*; D011820:Rabies virus / Q000276:immunology; D014611:Vaccination
chemical_list: D000998:Antiviral Agents; D011819:Rabies Vaccines