title: Turnover ability of a designed RNA acting as a template for chemical peptide ligation.
abstract: A designed self-folding RNA possessing two peptide-recognition motifs served as a template for the chemical ligation of two RNA-binding peptides under stoichiometric conditions. In this study, we investigated the turnover ability of this template RNA in facilitation of peptide ligation and found that the RNA exhibited modest turnover ability under conditions in which its 3D structure was marginally stable.
authors: Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Fukuoka, Japan.
authors: Kohei
authors: K
authors: Yamashita
authors: Norimasa
authors: N
authors: Kashiwagi
authors: Hiroyuki
authors: H
authors: Furuta
authors: Yoshiya
authors: Y
authors: Ikawa
mesh_terms: D001483:Base Sequence; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism*; D012313:RNA / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D059370:RNA Folding; D020871:RNA Stability; D016601:RNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism
chemical_list: D010455:Peptides; D016601:RNA-Binding Proteins; D012313:RNA