title: Chemical composition and antimicrobial activity of the essential oil of Anthemis altissima L. var. altissima.
abstract: The essential oil obtained from the flowering parts of Anthemis altissima L. var. altissima was analysed by gas chromatography and gas chromatography mass spectroscopy. In this study, 34 compounds representing 98.76% of the essential oil were identified. The main components were α-terpineol (26.42%), β-pinene (9.23%), cis-chrysanthenyl acetate (6.30%), globulol (5.36%), n-tricosane (4.41%), terpinen-4-ol (4.08%) and 1,8 cineole (3.84%). Antibacterial activities of the essential oil and its two major components (α-terpineol and β-pinene) were determined using microdilution method against both Gram-positive (Staphylococcus aureus, Bacillus subtilis, Staphylococcus epidermidis) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae) bacteria. The essential oil showed a broad-spectrum antibacterial activity (MICs ranged from 3.13 to 6.25 µL mL(-1)). It was found that α-terpineol with minimum inhibitory concentration (MIC) values of the range 0.87-1.56 µL mL(-1) was a more potent antibacterial agent than β-pinene with MIC values of the range 1.56-6.25 µL mL(-1). All of them, the essential oil, β-pinene and α-terpineol, were more effective against Gram-positive bacteria than Gram-negative ones.
authors: Department of Drug and Food Control, Faculty of Pharmacy and Pharmaceutical Quality Assurance Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors: Nasrin
authors: N
authors: Samadi
authors: Azadeh
authors: A
authors: Manayi
authors: Mahdi
authors: M
authors: Vazirian
authors: Mahtab
authors: M
authors: Samadi
authors: Zahra
authors: Z
authors: Zeinalzadeh
authors: Zahra
authors: Z
authors: Saghari
authors: Neda
authors: N
authors: Abadian
authors: Vali-O-Allah
authors: VO
authors: Mozaffarian
authors: Mahnaz
authors: M
authors: Khanavi
mesh_terms: D000473:Alkanes / Q000737:chemistry; D031166:Anthemis / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D000081008:Bicyclic Monoterpenes; D001643:Bridged Bicyclo Compounds / Q000737:chemistry / Q000494:pharmacology; D000081005:Cyclohexane Monoterpenes; D053138:Cyclohexenes / Q000737:chemistry / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D039821:Monoterpenes / Q000737:chemistry / Q000494:pharmacology; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000737:chemistry
chemical_list: D000473:Alkanes; D000890:Anti-Infective Agents; D000081008:Bicyclic Monoterpenes; D001643:Bridged Bicyclo Compounds; D000081005:Cyclohexane Monoterpenes; D053138:Cyclohexenes; D039821:Monoterpenes; D009822:Oils, Volatile; D012717:Sesquiterpenes; C016775:alpha-terpineol; C010789:beta-pinene; C059209:chrysanthenyl acetate; C531284:globulol; C554095:n-tricosane