title: Variation in genes of β-glucan recognition pathway and susceptibility to opportunistic infections in HIV-positive patients.
abstract: Opportunistic infections are the main cause of morbidity and death among HIV-positive patients. Most of these infections are linked to the immunodeficiency due to low CD4+ counts. However, not all patients with low CD4+ counts are equally susceptible to infections, and we hypothesize that variability in genes of innate immunity may also play an important role. The dectin-1/CARD9 pathway is crucial for recognition of both fungal and bacterial pathogens. The aim of this study was to assess the possible association between the occurrence of opportunistic infections and single nucleotide polymorphisms in DECTIN-1 and CARD9 in a cohort of 187 HIV-infected patients. The incidence of oropharyngeal candidiasis and other opportunistic infections was not influenced by either the Y238X DECTIN-1 or the S12N CARD9 polymorphism. Surprisingly however, the prevalence of pneumonia was significantly higher in patients bearing the defective variant DECTIN-1 allele. These results suggest a role of dectin-1 in the host defense against respiratory bacterial infections, and future studies are warranted to confirm this association.
authors: Department of Internal Medicine, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Geert Grooteplein 8, Nijmegen, The Netherlands.
authors: Diana C
authors: DC
authors: Rosentul
authors: Theo S
authors: TS
authors: Plantinga
authors: Antonios
authors: A
authors: Papadopoulos
authors: Leo A B
authors: LA
authors: Joosten
authors: Anastasia
authors: A
authors: Antoniadou
authors: Hanka
authors: H
authors: Venselaar
authors: Bart-Jan
authors: BJ
authors: Kullberg
authors: Jos W M
authors: JW
authors: van der Meer
authors: Evangelos J
authors: EJ
authors: Giamarellos-Bourboulis
authors: Mihai G
authors: MG
authors: Netea
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology / Q000235:genetics* / Q000382:microbiology; D000328:Adult; D053468:CARD Signaling Adaptor Proteins / Q000235:genetics*; D002180:Candidiasis, Oral / Q000453:epidemiology / Q000235:genetics* / Q000382:microbiology; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006679:HIV Seropositivity / Q000150:complications* / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D007113:Immunity, Innate; D015994:Incidence; D037181:Lectins, C-Type / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D000099181:Dectin-1
chemical_list: D053468:CARD Signaling Adaptor Proteins; D037181:Lectins, C-Type; D000099181:Dectin-1; C505855:CARD9 protein, human