title: Association of Arg194Trp, Arg280His and Arg399Gln polymorphisms in X-ray repair cross-complementing group 1 gene and risk of differentiated thyroid carcinoma in Iran.
abstract: X-ray repair cross-complementing group 1 (XRCC1) gene is a DNA repair gene and its non-synonymous single nucleotide polymorphisms (SNP) may influence DNA repair capacity which has been considered as a modifying risk factor for cancer development.
  
  
  
  A case-control study was conducted to investigate impact of three frequently studied polymorphisms (Arg194Trp, Arg280His and Arg399Gln) on developing differentiated thyroid carcinoma (DTC).
  
  
  
  Increased risks for DTC were shown in homozygous (odds ratio [OR]: 3.66, 95% confidence interval [CI]: 0.38-35.60) and in dominant trait (OR: 1.22, 95% CI: 1.64-2.32) of Arg194Trp genotype. Also, for Arg280His genotype, an increased risk for DTC was shown in dominant trait (OR: 1.42, 95% confidence interval [CI]: 0.76-2.68), while a mildly reduction of risk for DTC (OR: 0.77, 95% [CI]: 0.50-1.17) was estimated in dominant Gln genotype of Arg399Gln. Considering combinatory effects of Arg194Trp and Arg280His genotypes on DTC, the calculated OR and 95% CI for being heterozygous for one of Arg194Trp or Arg280His genotypes were 1.57 and 0.90-2.74, respectively.
  
  
  
  Genotyping of codons 194, 280 and 399 in XRCC1 gene may use in risk assessment of DTC.
authors: Dept. of Biochemistry, Pasteur Institute of Iran, Tehran, Iran. fard-esfahani@pasteur.ac.ir
authors: Pezhman
authors: P
authors: Fard-Esfahani
authors: Research Institute for Nuclear Medicine, 
  Tehran University of Medical Sciences, Tehran, Iran.
authors: Armaghan
authors: A
authors: Fard-Esfahani
authors: Dept. of Biochemistry, Pasteur Institute of Iran, Tehran, Iran. fard-esfahani@pasteur.ac.ir
authors: Shima
authors: S
authors: Fayaz
authors: Dept. of Biochemistry and Genetics, 
  Payam-e-Noor University of Tehran, Tehran, Iran.
authors: Bahareh
authors: B
authors: Ghanbarzadeh
authors: Dept. of Biochemistry, Pasteur Institute of Iran, Tehran, Iran. fard-esfahani@pasteur.ac.ir
authors: Parinaz
authors: P
authors: Saidi
authors: Dept. of Biochemistry, Pasteur Institute of Iran, Tehran, Iran. fard-esfahani@pasteur.ac.ir
authors: Reyhaneh
authors: R
authors: Mohabati
authors: Dept. of Biochemistry and Genetics, 
  Payam-e-Noor University of Tehran, Tehran, Iran.
authors: Seyed Kazem
authors: SK
authors: Bidoki
authors: Research Institute for Nuclear Medicine, 
  Tehran University of Medical Sciences, Tehran, Iran.
authors: Mina
authors: M
authors: Majdi
mesh_terms: D001120:Arginine / Q000235:genetics; D001483:Base Sequence; D016022:Case-Control Studies; D002454:Cell Differentiation; D017931:DNA Primers; D005260:Female; D005816:Genetic Complementation Test; D005998:Glycine / Q000235:genetics; D006639:Histidine / Q000235:genetics; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013964:Thyroid Neoplasms / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology; D014364:Tryptophan / Q000235:genetics
chemical_list: D017931:DNA Primers; D006639:Histidine; D014364:Tryptophan; D001120:Arginine; D005998:Glycine