title: In search of prognostic indicators for lymphomatoid papulosis: a retrospective study of 123 patients.
abstract: BACKGROUND
  Lymphomatoid papulosis (LyP) is a benign recurrent papulonodular skin eruption with histologically malignant features that sometimes (10%-20%) progresses to lymphoma.
  
  
  OBJECTIVE
  We retrospectively evaluated the clinical course of patients with LyP and identify prognostic factors possibly indicating a malignant course.
  
  
  METHODS
  Clinical, histopathologic, and immunologic features and molecular genetics were examined and correlated with clinical course and outcomes. Immunophenotyping and chemokine profiling were performed in select skin biopsy samples. A follow-up questionnaire was sent to patients. Clinical course and association with neoplastic disorders were correlated with LyP subtypes, molecular genetics, and immunophenotyping studies.
  
  
  RESULTS
  Of 123 patients with LyP (1991-2008) followed up a mean of 4 years (range, 2 months to 14 years), 17 (14%) had an associated hematologic malignancy, 8 of which were mycosis fungoides. Histopathologic analyses demonstrated classic LyP type A (n = 69), B (n = 13), or C (n = 6), and a slight predominance of T-cell CD8 marker expression for type A. More than one type of lesion was present in 9 patients with a higher incidence of hematologic malignancies. T-cell receptor gene rearrangement positivity was about two times higher, with LyP associated with hematologic malignancy (82% vs 44%; odds ratio 5.7; P = .02). Chemokine studies in a subset of 25 patients showed chemokine receptor (CCR) CCR4(+) and thymus and activation-related chemokine (TARC(+)) in all LyP types and CCR3(+) and chemokine-related receptor (CXCR) CXCR3(+) in types B and C.
  
  
  CONCLUSIONS
  Retrospective study design is a limitation.
  
  
  CONCLUSIONS
  Positive T-cell receptor gene rearrangement or diagnosis of mixed-type LyP may be a prognostic indicator of disease more prone to progress to lymphoma.
authors: Department of Dermatology, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors: Aieska
authors: A
authors: de Souza
authors: Rokea A
authors: RA
authors: el-Azhary
authors: Michael J
authors: MJ
authors: Camilleri
authors: David A
authors: DA
authors: Wada
authors: David L
authors: DL
authors: Appert
authors: Lawrence E
authors: LE
authors: Gibson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D020869:Gene Expression Profiling; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D017731:Lymphomatoid Papulosis / Q000235:genetics / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000235:genetics / Q000276:immunology; D055815:Young Adult
chemical_list: D011948:Receptors, Antigen, T-Cell