title: Design, synthesis and biological evaluation of substituted 11H-benzo[a]carbazole-5-carboxamides as novel antitumor agents.
abstract: A series of novel 11H-benzo[a]carbazole-5-carboxamide derivatives were designed, synthesized and evaluated for their antitumor activity against human cancer A549 and HCT-116 cell lines. Most of the compounds showed potent antitumor activities, and compound 8 displayed remarkable in vitro and in vivo anticancer activity comparable to that of amonafide.
authors: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, 555 Zu Chong Zhi Road, Shanghai 201203, PR China.
authors: Yu-Qin
authors: YQ
authors: Wang
authors: Xiao-Hua
authors: XH
authors: Li
authors: Qian
authors: Q
authors: He
authors: Yi
authors: Y
authors: Chen
authors: Yu-Yuan
authors: YY
authors: Xie
authors: Jian
authors: J
authors: Ding
authors: Ze-Hong
authors: ZH
authors: Miao
authors: Chun-Hao
authors: CH
authors: Yang
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D002227:Carbazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D059447:Cell Cycle Checkpoints / Q000187:drug effects; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009369:Neoplasms / Q000188:drug therapy; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D000970:Antineoplastic Agents; D002227:Carbazoles; C041514:carbazole