title: Seroprevalence and incidence of transfusion-transmitted infectious diseases among blood donors from regional blood transfusion centres in Burkina Faso, West Africa.
abstract: OBJECTIVE
  The high prevalence of numerous transfusion-transmitted infectious diseases such as HIV, HBV, HCV and syphilis in sub-Saharan Africa affects blood safety for transfusion recipients. The aim of this study was to evaluate the prevalence and incidence of transfusion-transmissible infectious diseases among blood donors in Burkina Faso.
  
  
  METHODS
  A retrospective study of blood donors' records from January to December 2009 was conducted. Prevalence and incidence of viral infections were calculated among repeat and first-time blood donors.
  
  
  RESULTS
  Of the total of 31405 first-time volunteer blood donors in 2009, 24.0% were infected with at least one pathogen and 1.8% had serological evidence of multiple infections. The seroprevalence of HIV, HBV, HCV and syphilis in first-time volunteer donors was 1.8%, 13.4%, 6.3% and 2.1%, respectively. In 3981 repeat donors, the incidence rate was 3270.2, 5874.1 and 6784.6 per 100000 donations for anti-HIV-1, HBsAg and anti-HCV, respectively. These numbers varied significantly according to populations where blood is collected and blood centres in Burkina Faso.
  
  
  CONCLUSIONS
  The relatively high prevalence of viral markers in first-time volunteers and remarkably high incidence of infections in repeat donors raise concerns regarding the safety of these donors and suggest that implementation of NAT might significantly improve the situation.
authors: Centre National de Transfusion Sanguine, Ouagadougou, Burkina Faso  Centre de Recherche Biomoléculaire Pietro Annigoni, Ouagadougou, Burkina Faso.
authors: Bolni Marius
authors: BM
authors: Nagalo
authors: Cyrille
authors: C
authors: Bisseye
authors: Mahamoudou
authors: M
authors: Sanou
authors: Kisito
authors: K
authors: Kienou
authors: Yacouba K
authors: YK
authors: Nebié
authors: Alice
authors: A
authors: Kiba
authors: Honorine
authors: H
authors: Dahourou
authors: Siaka
authors: S
authors: Ouattara
authors: Jean Baptiste
authors: JB
authors: Nikiema
authors: Rémy
authors: R
authors: Moret
authors: Jean Didier
authors: JD
authors: Zongo
authors: Jacques
authors: J
authors: Simpore
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001782:Blood Donors / Q000706:statistics & numerical data; D002050:Burkina Faso / Q000453:epidemiology; D003141:Communicable Diseases / Q000097:blood* / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000453:epidemiology / Q000635:transmission*; D006509:Hepatitis B / Q000097:blood / Q000453:epidemiology / Q000635:transmission*; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006526:Hepatitis C / Q000097:blood / Q000453:epidemiology / Q000635:transmission*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D016036:Seroepidemiologic Studies; D013587:Syphilis / Q000097:blood / Q000453:epidemiology / Q000635:transmission*; D065227:Transfusion Reaction; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D015415:Biomarkers; D006514:Hepatitis B Surface Antigens