title: Preventive and therapeutic strategies for bovine leukemia virus: lessons for HTLV.
abstract: Bovine leukemia virus (BLV) is a retrovirus closely related to the human T-lymphotropic virus type 1 (HTLV-1). BLV is a major animal health problem worldwide causing important economic losses. A series of attempts were developed to reduce prevalence, chiefly by eradication of infected cattle, segregation of BLV-free animals and vaccination. Although having been instrumental in regions such as the EU, these strategies were unsuccessful elsewhere mainly due to economic costs, management restrictions and lack of an efficient vaccine. This review, which summarizes the different attempts previously developed to decrease seroprevalence of BLV, may be informative for management of HTLV-1 infection. We also propose a new approach based on competitive infection with virus deletants aiming at reducing proviral loads.
authors: Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics (GIGA), University of Liège (ULg), 4000, Liège, Belgium. Sabrina.Rodriguez@ulg.ac.be
authors: Sabrina M
authors: SM
authors: Rodríguez
authors: Arnaud
authors: A
authors: Florins
authors: Nicolas
authors: N
authors: Gillet
authors: Alix
authors: A
authors: de Brogniez
authors: María Teresa
authors: MT
authors: Sánchez-Alcaraz
authors: Mathieu
authors: M
authors: Boxus
authors: Fanny
authors: F
authors: Boulanger
authors: Gerónimo
authors: G
authors: Gutiérrez
authors: Karina
authors: K
authors: Trono
authors: Irene
authors: I
authors: Alvarez
authors: Lucas
authors: L
authors: Vagnoni
authors: Luc
authors: L
authors: Willems
mesh_terms: D000818:Animals; D002353:Carrier State / Q000517:prevention & control* / Q000662:veterinary* / Q000821:virology; D002417:Cattle; D016583:Enzootic Bovine Leukosis / Q000517:prevention & control* / Q000821:virology; D015490:HTLV-I Infections / Q000517:prevention & control* / Q000821:virology; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification*; D006801:Humans; D001909:Leukemia Virus, Bovine / Q000302:isolation & purification*