title: Fully substituted unsaturated lactones from endophytic Myrothecium sp.
abstract: Two new α,β-unsaturated γ-lactones, myrolactones A (1) and B (2), were characterized from the culture broth of the Myrothecium sp. IFB-E106 isolated from the roots of Vatica mangachapoi Blauco. The absolute configuration was determined by the computational electronic circular dichroism approach. Myolactone B showed neuraminidase inhibitory activity with the IC(50) value of 13.95 μM.
authors: State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing, 210093, China.
authors: Hao
authors: H
authors: Xu
authors: Nan
authors: N
authors: Jiang
authors: Ye
authors: Y
authors: Guo
authors: Rui-Hua
authors: RH
authors: Jiao
authors: Jiang-Tao
authors: JT
authors: Cui
authors: Yong-Chun
authors: YC
authors: Song
authors: Ren-Xiang
authors: RX
authors: Tan
mesh_terms: D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D053958:Dipterocarpaceae / Q000382:microbiology; D006999:Hypocreales / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D018517:Plant Roots / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D007783:Lactones; C569277:myrolactone A; C569278:myrolactone B; D009439:Neuraminidase