title: Maternal waist to hip ratio is a risk factor for macrosomia.
abstract: OBJECTIVE
  Fetal growth during pregnancy may be affected by the metabolic activity and distribution of fat stores in women. This study investigates the association between waist to hip ratio (WHR) as a measure of the distribution of adiposity in primiparous mothers living in Avon, England, and macrosomia in their offspring.
  
  
  METHODS
  Prospective historical cohort study.
  
  
  METHODS
  The Avon Longitudinal Study of Parents and Children (ALSPAC) prospective cohort study in Avon, UK.
  
  
  METHODS
  A cohort of 3083 primiparous women with a term singleton delivery with expected dates of delivery from 1 April 1991 to 31 December 1992.
  
  
  METHODS
  The distribution of WHR was categorised into quartiles. We compared the second, third and fourth quartiles against the first (reference) quartile with respect to whether the mother delivered a macrosomic newborn. We controlled for maternal age, gestational age, body mass index (BMI), marital status and racial group using multivariate logistic regression.
  
  
  METHODS
  Macrosomia defined in three ways: birthweight ≥ 4000 g; birthweight ≥ 4500 g; large for gestational age (LGA: ≥ 95th percentile of birth weight adjusted for sex and gestational age).
  
  
  RESULTS
  Waist to hip ratios in the third and fourth quartiles were associated with a higher odds of delivering a macrosomic infant, defined as a birthweight ≥ 4000 g (third quartile, OR 1.59, 95% CI 1.12-2.26; fourth quartile, OR 1.69, 95% CI 1.18-2.42) or as LGA (≥95th percentile of the cohort; third quartile, OR 1.77, 95% CI 1.10-2.85; fourth quartile, OR 1.78, 95% CI 1.09-2.91). When defined as a birthweight ≥ 4500 g, the fourth quartile was associated with increased odds of macrosomia (OR 2.74, 95% CI 1.05-7.16). Odds ratios after adjustment for confounding factors followed a similar pattern.
  
  
  CONCLUSIONS
  Independent of confounding factors, women with increased WHRs were significantly more likely to give birth to macrosomic newborns.
authors: Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
authors: W
authors: W
authors: Salem
authors: A I
authors: AI
authors: Adler
authors: C
authors: C
authors: Lee
authors: G C S
authors: GC
authors: Smith
mesh_terms: D000328:Adult; D001724:Birth Weight; D005260:Female; D005320:Fetal Macrosomia / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D016015:Logistic Models; D015999:Multivariate Analysis; D016017:Odds Ratio; D011247:Pregnancy; D011446:Prospective Studies; D012307:Risk Factors; D057566:Self Report; D049629:Waist-Hip Ratio / Q000009:adverse effects*