title: Menin prevents liver steatosis through co-activation of peroxisome proliferator-activated receptor alpha.
abstract: Fatty liver is strongly associated with metabolic syndrome. Here, we show that the impaired hepatic expression of menin, the product of the MEN1 (multiple endocrine neoplasia type 1) tumor suppressor gene, represents a common feature of several fatty liver mouse models. The liver specific ablation of MEN1 gene expression in healthy mice induced hepatic steatosis under high-fat dietary conditions. Moreover, overexpression of menin in livers of steatotic db/db mice reduced liver triglyceride accumulation. At the molecular level, we found that menin acts synergistically with the nuclear receptor PPARα to control gene expression of fatty acid oxidation. Collectively, these data suggest a crucial role for menin as an integrator of the complex transcriptional network controlling hepatic steatosis.
authors: Department of General Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, People's Republic of China. dfbbcxjh@Gmail.com
authors: Peng
authors: P
authors: Cheng
authors: Sheng Sheng
authors: SS
authors: Yang
authors: Xian Gui
authors: XG
authors: Hu
authors: Xu Yu
authors: XY
authors: Zhou
authors: Yi Jie
authors: YJ
authors: Zhang
authors: Gang
authors: G
authors: Jin
authors: Ying Qi
authors: YQ
authors: Zhou
mesh_terms: D000818:Animals; D015536:Down-Regulation / Q000235:genetics; D005234:Fatty Liver / Q000235:genetics / Q000378:metabolism* / Q000517:prevention & control; D055785:Gene Knockdown Techniques; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D009928:Organ Specificity; D047493:PPAR alpha / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D034741:RNA, Small Interfering / Q000235:genetics
chemical_list: C484898:Men1 protein, mouse; D047493:PPAR alpha; D011518:Proto-Oncogene Proteins; D034741:RNA, Small Interfering