title: Medicinal chemistry for 2020.
abstract: Rapid advances in our collective understanding of biomolecular structure and, in concert, of biochemical systems, coupled with developments in computational methods, have massively impacted the field of medicinal chemistry over the past two decades, with even greater changes appearing on the horizon. In this perspective, we endeavor to profile some of the most prominent determinants of change and speculate as to further evolution that may consequently occur during the next decade. The five main angles to be addressed are: protein-protein interactions; peptides and peptidomimetics; molecular diversity and pharmacological space; molecular pharmacodynamics (significance, potential and challenges); and early-stage clinical efficacy and safety. We then consider, in light of these, the future of medicinal chemistry and the educational preparation that will be required for future medicinal chemists.
authors: Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Drive, Monroe LA 71201, USA. jois@ulm.edu
authors: Seetharama D
authors: SD
authors: Satyanarayanajois
authors: Ronald A
authors: RA
authors: Hill
mesh_terms: D002626:Chemistry, Pharmaceutical; D015195:Drug Design; D018716:Molecular Mimicry; D010455:Peptides / Q000737:chemistry; D010600:Pharmacology; D011485:Protein Binding
chemical_list: D010455:Peptides