title: E-cadherin/β-catenin complex and the epithelial barrier.
abstract: E-Cadherin/β-catenin complex plays an important role in maintaining epithelial integrity and disrupting this complex affect not only the adhesive repertoire of a cell, but also the Wnt-signaling pathway. Aberrant expression of the complex is associated with a wide variety of human malignancies and disorders of fibrosis resulting from epithelial-mesenchymal transition. These associations provide insights into the complexity that is likely responsible for the fibrosis/tumor suppressive action of E-cadherin/β-catenin.
authors: Centre for Transplantation and Renal Research, Westmead Millennium Institute, The University of Sydney, NSW 2145, Australia.
authors: Xinrui
authors: X
authors: Tian
authors: Zhuola
authors: Z
authors: Liu
authors: Bo
authors: B
authors: Niu
authors: Jianlin
authors: J
authors: Zhang
authors: Thian Kui
authors: TK
authors: Tan
authors: So Ra
authors: SR
authors: Lee
authors: Ye
authors: Y
authors: Zhao
authors: David C H
authors: DC
authors: Harris
authors: Guoping
authors: G
authors: Zheng
mesh_terms: D015820:Cadherins / Q000235:genetics / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics / Q000502:physiology*; D004848:Epithelium / Q000378:metabolism* / Q000473:pathology; D005355:Fibrosis; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D060449:Wnt Signaling Pathway / Q000502:physiology*; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism*
chemical_list: D015820:Cadherins; D051176:beta Catenin