title: Effects of a plum (Prunus mume Siebold and Zucc.) ethanol extract on the immune system in vivo and in vitro.
abstract: The effect of a plum ethanol extract (PEE) on immunity was analyzed. An oral administration of PEE increased the interleukin (IL)-12p40 concentration in the serum and T-cell ratio in the spleen. In vitro studies revealed that PEE stimulated IL-12p70 production in peritoneal macrophages and natural killer activity. These findings suggest that PEE enhanced the immune function by stimulating innate immune cells.
authors: Central Laboratories for Frontier Technology, Kirin Holdings Co., Ltd., Yokohama, Kanagawa, Japan. Ryohei_Tsuji@kirin.co.jp
authors: Ryohei
authors: R
authors: Tsuji
authors: Hideki
authors: H
authors: Koizumi
authors: Daisuke
authors: D
authors: Fujiwara
mesh_terms: D000818:Animals; D000431:Ethanol / Q000737:chemistry*; D005260:Female; D007113:Immunity, Innate / Q000187:drug effects*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D027861:Prunus / Q000737:chemistry*
chemical_list: D010936:Plant Extracts; D000431:Ethanol