title: Altered expression of phosphatase of regenerating liver gene family             in non-small cell lung cancer.
abstract: Protein tyrosine phophatases (PTPs) are implicated in the tumorigenesis             and metastasis of human cancer. The phosphatase of regenerating liver (PRL) gene             family, a subgroup of PTPs is also linked to these processes. In many solid cancers,             high levels of PRL-3 expression are related with metastasis and poor prognosis.             However, the expression patterns of PRL-1 and -2 have not been explored in lung             cancer yet. Thus, we investigated the expression levels of PRL-1, -2 and -3 in             the tissues of primary lung cancer patients. The protein expression levels of             PRL-2, but not PRL-1 and -3 were increased in cancer tissues. However, there was             no correlation between mRNA and protein expression levels of the PRLs. Reporter             assays showed that PRLs suppressed the activity of the p21 promoter but promoted             AP-1 activity. Furthermore, transfection of PRLs showed significantly increased             cell proliferation. Therefore, these results suggest that PRL-2 plays an important             role in lung cancer and can be a biomarker of lung cancer, substituting for the             function of other PRLs.
authors: Graduate School of Medical Science and Engineering, Biomedical Research Center, KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology, and Department of Thoracic and Cardiovascular Surgery, Eulji University Hospital, Daejeon 305-701, Republic of Korea.
authors: Jung-Joo
authors: JJ
authors: Hwang
authors: Sang-Hyun
authors: SH
authors: Min
authors: Ki-Hyuk
authors: KH
authors: Sin
authors: Young-Shin
authors: YS
authors: Heo
authors: Kil-Dong
authors: KD
authors: Kim
authors: Ook-Joon
authors: OJ
authors: Yoo
authors: Seung-Hyo
authors: SH
authors: Lee
mesh_terms: D000368:Aged; D000818:Animals; D002289:Carcinoma, Non-Small-Cell Lung / Q000201:enzymology* / Q000235:genetics; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000235:genetics; D005260:Female; D015870:Gene Expression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology* / Q000235:genetics; D008297:Male; D051379:Mice; D008875:Middle Aged; D041681:NIH 3T3 Cells; D017027:Protein Tyrosine Phosphatases / Q000235:genetics / Q000378:metabolism*; D018808:Transcription Factor AP-1 / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D050759:Cyclin-Dependent Kinase Inhibitor p21; D018808:Transcription Factor AP-1; C487561:PTP4A2 protein, human; D017027:Protein Tyrosine Phosphatases