title: [Influence of aqueous extract of Aralia echinocaulis Hand.-Mazz on the expression of fracture healing-related factor receptors].
abstract: OBJECTIVE
  To investigate the influence of aqueous extract of Aralia echinocaulis Hand.-Mazz on the expression of fracture healing-ralated factor receptors.
  
  
  METHODS
  Single factor model was set up in SD rat. Selecting 14 and 28 days in the experiment. Immunohistochemistry was employed to determine the expression of Fibroblast growth factor receptor 2 (FGFR2), Fms-like tyrosine kinase (Flt-1) and Fetal licer kinase (Flk-1) at 14 and 28 days after model establishing.
  
  
  RESULTS
  The expression of Flt-1 and Flk-1 at 14 days (the latter was more remarkable) were obviously promoted in High dose group of aqueous extract of Aralia echinocaulis Hand.-Mazz, and higher than that in normal group and model group. The expression of FGFR2 in the high dose group of Aralia echinocaulis Hand -Mazz was also promoted visibility, close to that in the compare group (traditional Chinese medicine), but higher than than in the model group. There was no significant difference among them. At 28 days, the expression of FGFR2, Flt-1 and Flk-1 in all groups decreased except normal group, and got higher expression in model groups than each control groups.
  
  
  CONCLUSIONS
  Aqueous extract of Aralia echinocaulis Hand.-Mazz can promote angiogenesis in fracture healing, improve the activity and aggregation of fibroblasts, osteoblasts and chondrocytes. It also helps to quicken ossification in the cartilage and promote fracture healing.
authors: Department of Orthopaedics, Wangjing Hospital Affiliated to China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors: Xia
authors: X
authors: Yin
authors: Li
authors: L
authors: Li
authors: Ling-ling
authors: LL
authors: Zheng
authors: Wan-qiang
authors: WQ
authors: Zhang
authors: Jia
authors: J
authors: Zhu
authors: Ling-peng
authors: LP
authors: Pei
authors: Fu-hui
authors: FH
authors: Dong
mesh_terms: D000818:Animals; D027983:Aralia / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D005260:Female; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D007150:Immunohistochemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D004365:Drugs, Chinese Herbal; D042461:Vascular Endothelial Growth Factor A; D005346:Fibroblast Growth Factors