title: Simvastatin modulates the Alzheimer's disease-related gene seladin-1.
abstract: This work describes a novel mechanism of neuroprotection by simvastatin: the modulation of seladin-1, an enzyme involved in Alzheimer's disease. Genomic and proteomic studies in human neuronal cells showed seladin-1 production to be increased in a dose- and time-dependent manner by simvastatin. This was confirmed in mice by immunohistochemical and qRT-PCR studies.
authors: Neuron BIO, BioPharma Division, Parque Tecnológico de Ciencias de la Salud, Edificio BIC, Armilla, Granada, Spain.
authors: Maria C
authors: MC
authors: Ramos
authors: Saleta
authors: S
authors: Sierra
authors: Carlos
authors: C
authors: Ramirez
authors: Javier
authors: J
authors: Velasco
authors: Javier S
authors: JS
authors: Burgos
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D006801:Humans; D051379:Mice; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D009447:Neuroblastoma / Q000473:pathology; D044925:Oxidoreductases Acting on CH-CH Group Donors / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D019821:Simvastatin / Q000494:pharmacology*; D013997:Time Factors; D015854:Up-Regulation / Q000187:drug effects*
chemical_list: D000924:Anticholesteremic Agents; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D019821:Simvastatin; D044925:Oxidoreductases Acting on CH-CH Group Donors; C499055:DHCR24 protein, human