title: Point-to-volume registration of prostate implants to ultrasound.
abstract: Ultrasound-Fluoroscopy fusion is a key step toward intraoperative dosimetry for prostate brachytherapy. We propose a method for intensity-based registration of fluoroscopy to ultrasound that obviates the need for seed segmentation required for seed-based registration. We employ image thresholding and morphological and Gaussian filtering to enhance the image intensity distribution of ultrasound volume. Finally, we find the registration parameters by maximizing a point-to-volume similarity metric. We conducted an experiment on a ground truth phantom and achieved registration error of 0.7 +/- 0.2 mm. Our clinical results on 5 patient data sets show excellent visual agreement between the registered seeds and the ultrasound volume with a seed-to-seed registration error of 1.8 +/- 0.9mm. With low registration error, high computational speed and no need for manual seed segmentation, our method is promising for clinical application.
authors: Johns Hopkins University, USA.
authors: Ehsan
authors: E
authors: Dehghan
authors: Junghoon
authors: J
authors: Lee
authors: Pascal
authors: P
authors: Fallavollita
authors: Nathanael
authors: N
authors: Kuo
authors: Anton
authors: A
authors: Deguet
authors: E Clif
authors: EC
authors: Burdette
authors: Danny
authors: D
authors: Song
authors: Jerry L
authors: JL
authors: Prince
authors: Gabor
authors: G
authors: Fichtinger
mesh_terms: D000465:Algorithms; D001918:Brachytherapy / Q000379:methods*; D003201:Computers; D006801:Humans; D008297:Male; D015233:Models, Statistical; D016011:Normal Distribution; D019047:Phantoms, Imaging; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011881:Radiotherapy, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012984:Software