title: A modular approach to trim cellular targets in anticancer drug discovery.
abstract: A Phenotypic Drug Discovery strategy was applied to study a set of pyrimidine analogs prepared by means of intramolecular oxidation-reduction reactions of N-substituted-N-(2,6-disubstituted-5-nitro-4-pyrimidinyl)aminoacetic acid methyl esters in basic media. The combined and rational use of specific assays allowed in short time reducing from all possible cellular targets to those involved in metaphase to anaphase transition.
authors: BioLab, Instituto Universitario de Bio-Orgánica Antonio González (IUBO-AG), Universidad de La Laguna, C/ Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.
authors: Carla
authors: C
authors: Ríos-Luci
authors: Raquel
authors: R
authors: Domínguez-Kelly
authors: Leticia G
authors: LG
authors: León
authors: Elena
authors: E
authors: Díaz-Rodríguez
authors: Raimundo
authors: R
authors: Freire
authors: Atanasio
authors: A
authors: Pandiella
authors: Inga
authors: I
authors: Cikotiene
authors: José M
authors: JM
authors: Padrón
mesh_terms: D000705:Anaphase / Q000187:drug effects; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects*; D045744:Cell Line, Tumor; D055808:Drug Discovery; D006801:Humans; D008677:Metaphase / Q000187:drug effects; D009369:Neoplasms / Q000188:drug therapy; D010084:Oxidation-Reduction; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D011743:Pyrimidines