title: Vitamin D deficiency and primary hyperparathyroidism.
abstract: Vitamin D via its receptor has essential actions on parathyroid cells, inhibiting PTH secretion, and parathyroid cell proliferation. While the effects of vitamin D depletion in the pathogenesis of secondary hyperparathyroidism in elderly individuals or in the occurrence of parathyroid hyperplasia in patients with renal insufficiency are well established, the association between hypovitaminosis D and primary hyperparathyroidism (P-HPT) has only recently become appreciated. In different cohorts of patients with P-HPT, vitamin D deficiency has been recently associated with higher PTH levels, larger adenomas, and a more severe phenotype (including osteitis fibrosa cystica) as well as negative post-operative outcomes following parathyroidectomy. Despite current guidelines recommend measurement of serum 25OHD (25-hydroxy-cholecalciferol) in P-HPT and their repletion if the levels are <20 ng/ml, future well-designed trials of vitamin D supplementation in P-HPT patients with coexisting vitamin D deficiency are needed to evaluate the risk/benefit profile of this treatment.
authors: Department of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, University of Siena, Viale Braccci, 53100 Siena, Italy. nutir@unisi.it
authors: R
authors: R
authors: Nuti
authors: D
authors: D
authors: Merlotti
authors: L
authors: L
authors: Gennari
mesh_terms: D015652:25-Hydroxyvitamin D 2 / Q000097:blood; D000236:Adenoma / Q000473:pathology; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000209:etiology* / Q000628:therapy; D010281:Parathyroid Hormone / Q000097:blood; D016105:Parathyroidectomy / Q000009:adverse effects; D017698:Postmenopause; D014807:Vitamin D / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000150:complications*
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D; D015652:25-Hydroxyvitamin D 2