title: Solidified mPEG-PDLLA micelles as a novel oral delivery system of indomethacin.
abstract: In this study, indomethacin (IND) loaded solidified-polymeric micelles (IND-SPM) were prepared. Their in vitro characteristics were investigated. Methoxy-poly(ethylene glycol) poly(D, L-lactide) copolymer (mPEG-PDLLA) was used as IND carrier. The preparation of IND-SPM was conducted by solution-absorption method and evaporation by rotary evaporator. Polyplasdone XL-10 was used as adsorbent. The solution-absorption method was conducted by the following procedure; IND and mPEG-PDLLA were dissolved in acetone, followed by addition of polyplasdone XL-10 and stirred to obtain a suspension. The powder of IND-SPM was simply obtained after the organic solvent was completely evaporated. More than 90% (w/w) of IND (20 mg) in the powder was dissolved in 250 mL PBS within 30 min. DSC, 1H NMR and SEM results proved that IND was encapsulated within mPEG-PDLLA. The solubility of IND in the system increased 4.6 times with the highest amount of copolymer. The solidified particles were found to be suitable for the formulation of tablets or capsules.
authors: Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China.
authors: Ouahab
authors: O
authors: Ammar
authors: Yan
authors: Y
authors: Shen
authors: Qi-Neng
authors: QN
authors: Ping
authors: Jia-Sheng
authors: JS
authors: Tu
mesh_terms: D000284:Administration, Oral; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D004339:Drug Compounding; D016503:Drug Delivery Systems; D007213:Indomethacin / Q000008:administration & dosage* / Q000737:chemistry; D008823:Micelles; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry; D012995:Solubility
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D008823:Micelles; D011091:Polyesters; C561465:methoxy poly(ethylene glycol)-block-poly(lactic acid); D011092:Polyethylene Glycols; D011205:Povidone; D007213:Indomethacin