title: Modeling nerve conduction criteria for diagnosis of diabetic polyneuropathy.
abstract: BACKGROUND
  In this study we aimed to determine which criteria are valid for nerve conduction (NC) diagnosis of typical diabetic sensorimotor polyneuropathy (DSPN).
  
  
  METHODS
  Eight criteria were assessed from among diabetes databases, the Rochester Diabetic Neuropathy Study (RDNS, N = 456), and in healthy subjects (RDNS-HS, N = 330).
  
  
  RESULTS
  In the RDNS, the most frequent abnormal attributes (≤2.5th/≥97.5th percentile) are: fibular motor nerve conduction velocity (MNCV; 26.3%); sural sensory nerve conduction velocity (SNAP; 25.4%); tibial MNCV (24.8%); ulnar MNCV (21.3%); fibular F latency (16.9%); and ulnar F latency (16.0%). Normal deviate (from percentiles) composite scores of NC included: representative of neurophysiological abnormalities; sensitive and specific for diagnosis and useful for epidemiological surveys; randomized trials; and medical practice. By contrast, abnormality of one or more attributes in any nerve or abnormally of two most sensitive attributes performed poorly.
  
  
  CONCLUSIONS
  Composite sum scores of normal deviates (from percentiles corrected for applicable variables) of sensitive NC attributes and with modifications, RDNS and AAN criteria performed acceptably for diagnosis of DSPN.
authors: Peripheral Neuropathy Research Laboratory, Department of Neurology Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA. dyck.peter@mayo.edu
authors: Peter J
authors: PJ
authors: Dyck
authors: Rickey E
authors: RE
authors: Carter
authors: William J
authors: WJ
authors: Litchy
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015331:Cohort Studies; D003929:Diabetic Neuropathies / Q000175:diagnosis* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology*; D010543:Peroneal Nerve / Q000503:physiopathology; D012680:Sensitivity and Specificity; D013497:Sural Nerve / Q000503:physiopathology; D013979:Tibial Nerve / Q000503:physiopathology; D014459:Ulnar Nerve / Q000503:physiopathology; D055815:Young Adult