title: TREM-1 expression on monocytes is not a parameter specific for infectious etiology of systemic inflammatory response syndrome.
abstract: Determination of mTREM-1 expression on monocytes has been             investigated as a perspective diagnostic method to distinguish infectious from             non-infectious etiology of the inflammation.
  
  
  OBJECTIVE
  i) to             investigate the expression of TREM-1 on monocytes in septic patients and in those             after elective spinal surgery without infection; ii) to assess the dynamics of mTREM-1             expression on monocytes and its association with the outcome in patients with             severe sepsis. Fifty two patients with severe sepsis, 20 healthy volunteers, and             20 patients after elective spinal surgery were involved in our study. TREM-1             expression on monocytes was evaluated by flow cytometry. Compared with the             group of healthy adults (median 42.0, interquartile range (IQR) 30.3-76 MFI),             mTREM-1 expression was increased in the group of septic patients both at entry             (median 138.4, IQR 78.4-187.5 MFI) and the last examination (median 136.5,             IQR 69.0-170.0 MFI) as well as in patients 24 hours after spinal surgery (median             138.5, IQR 45.3-165.5 MFI). The increase was statistically significant. mTREM-1             expression in patients undergoing spinal surgery and those with severe sepsis did             not differ. TREM-1 expression on the monocytes in survivors was higher than in             non-survivors (p=0.007). TREM-1 levels in septic non-surviving patients correlated             weakly with TNF-α levels (r=0.38; p=0.003) and with HLA-DR/CD14 levels             (r=0.38; p=0.003). Increased TREM-1 expression on monocytes is not associated             exclusively with the presence of systemic infection.
authors: Department of Clinical Biochemistry, Na Homolce Hospital, Prague, Czech Republic. miroslav.prucha@homolka.cz
authors: M
authors: M
authors: Průcha
authors: R
authors: R
authors: Zazula
authors: M
authors: M
authors: Müller
authors: T
authors: T
authors: Hyánek
authors: M
authors: M
authors: Dostál
authors: L
authors: L
authors: Sedláčková
mesh_terms: D000328:Adult; D005260:Female; D006684:HLA-DR Antigens / Q000378:metabolism; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000378:metabolism*; D013131:Spine / Q000601:surgery; D018746:Systemic Inflammatory Response Syndrome / Q000378:metabolism*; D000073871:Triggering Receptor Expressed on Myeloid Cells-1; D055815:Young Adult
chemical_list: D006684:HLA-DR Antigens; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1