title: Single- and 14-day repeat-dose toxicity of cross-linked β-cyclodextrin in rats.
abstract: The present study was carried out to investigate the oral single and repeat toxicity of cross-linked β-cyclodextrin (β-CD) made with adipic acid. Ten each of female and male rats were orally administered a 5000 mg/kg single dose. At this dose, mortality or macroscopic changes of internal organs were not observed. Dose levels 500, 1000, or 2000 mg/kg of β-CD were given daily to 5 each of female and male rats by oral gavage for 14 days. Body and organ weights were not significantly different during the study (P < .05). Hematology and clinical chemistry did not show any toxicity from the cross-linked β-CD. Macroscopic or microscopic changes were not observed between the controls and the treated rats. Based on these results, the cross-linked β-CD did not produce any signs of toxicity or other adverse effects at dose levels up to 2000 mg/kg per d for 14 days.
authors: Department of Food Science and Technology, Sejong University, Seoul, Korea.
authors: Ju-Hyun
authors: JH
authors: Park
authors: Kyung-Hoon
authors: KH
authors: Choi
authors: Hae-Soo
authors: HS
authors: Kwak
mesh_terms: D000272:Adipates / Q000737:chemistry; D000818:Animals; D003432:Cross-Linking Reagents / Q000737:chemistry; D005260:Female; D005503:Food Additives / Q000737:chemistry / Q000633:toxicity*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D023382:Toxicity Tests, Acute; D059551:Toxicity Tests, Subacute; D047392:beta-Cyclodextrins / Q000737:chemistry / Q000633:toxicity*
chemical_list: D000272:Adipates; D003432:Cross-Linking Reagents; D005503:Food Additives; D047392:beta-Cyclodextrins; C029900:adipic acid; C031215:betadex