title: Design, synthesis, and properties of boat-shaped glucopyranosyl nucleic acid.
abstract: A boat-shaped glucopyranosyl nucleic acid (BsNA) was synthesized to investigate the possibility that the lean of a nucleobase is a factor affecting duplex-forming ability of oligonucleotides. From the crystal structure of a BsNA nucleoside and the thermal stability of duplex oligonucleotides, it was found that not only the lean of the base but also the rotation angle of the glycosidic bond axis were important factors in a stable duplex formation.
authors: Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors: Kazuto
authors: K
authors: Mori
authors: Tetsuya
authors: T
authors: Kodama
authors: Satoshi
authors: S
authors: Obika
mesh_terms: D005947:Glucose / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009691:Nucleic Acid Denaturation; D009696:Nucleic Acids / Q000138:chemical synthesis*
chemical_list: D009696:Nucleic Acids; D005947:Glucose