title: A possible subcellular mechanism underlying the "French paradox": the opening of mitochondrial K(ATP) channels.
abstract: A reduction in the risk of coronary heart disease has been associated to moderate red wine consumption. We tested whether a nonalcoholic red wine extract would open mitochondrial K(ATP) channels in guinea pig myocytes. The opening of mitochondrial K(ATP) channels was assessed by endogenous flavoprotein fluorescence. Red wine extract (100 μg·mL(-1)) increased flavoprotein oxidation (10.9% ± 1.2%, n = 20). This effect was prevented by the mitochondrial K(ATP) channel blocker, 5-hydroxydecanoate (500 µmol·L(-1); 0.3% ± 1.1%, n = 13), confirming the hypothesis that red wine extract opens mitochondrial K(ATP) channels.
authors: Centro de Investigaciones Cardiovasculares, Facultad de Ciencias Médicas, UNLP, La Plata, Argentina. aaiello@med.unlp.edu.ar
authors: Ernesto A
authors: EA
authors: Aiello
authors: Horacio E
authors: HE
authors: Cingolani
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003327:Coronary Disease / Q000517:prevention & control*; D003652:Decanoic Acids / Q000494:pharmacology; D005420:Flavoproteins / Q000378:metabolism; D006168:Guinea Pigs; D006880:Hydroxy Acids / Q000494:pharmacology; D007700:Kinetics; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism*; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000378:metabolism*; D010084:Oxidation-Reduction; D010936:Plant Extracts / Q000378:metabolism; D026902:Potassium Channel Blockers / Q000494:pharmacology; D015221:Potassium Channels / Q000819:agonists* / Q000737:chemistry; D014920:Wine / Q000009:adverse effects / Q000032:analysis*
chemical_list: D003652:Decanoic Acids; D005420:Flavoproteins; D006880:Hydroxy Acids; D010936:Plant Extracts; D026902:Potassium Channel Blockers; D015221:Potassium Channels; C117780:mitochondrial K(ATP) channel; C052853:5-hydroxydecanoic acid