title: Predictors of long-term pain and disability in patients with low back pain investigated by magnetic resonance imaging: a longitudinal study.
abstract: BACKGROUND
  It is possible that clinical outcome of low back pain (LBP) differs according to the presence or absence of spinal abnormalities on magnetic resonance imaging (MRI), in which case there could be value in using MRI findings to refine case definition of LBP in epidemiological research. We therefore conducted a longitudinal study to explore whether spinal abnormalities on MRI for LBP predict prognosis after 18 months.
  
  
  METHODS
  A consecutive series of patients aged 20-64 years, who were investigated by MRI because of mechanical LBP (median duration of current episode 16.2 months), were identified from three radiology departments, and those who agreed completed self-administered questionnaires at baseline and after a mean follow-up period of 18.5 months (a mean of 22.2 months from MRI investigation). MRI scans were assessed blind to other clinical information, according to a standardised protocol. Associations of baseline MRI findings with pain and disability at follow-up, adjusted for treatment and for other potentially confounding variables, were assessed by Poisson regression and summarised by prevalence ratios (PRs) with their 95% confidence intervals (CIs).
  
  
  RESULTS
  Questionnaires were completed by 240 (74%) of the patients who had agreed to be followed up. Among these 111 men and 129 women, 175 (73%) reported LBP in the past four weeks, 89 (37%) frequent LBP, and 72 (30%) disabling LBP. In patients with initial disc degeneration there was an increased risk of frequent (PR 1.3, 95%CI 1.0-1.9) and disabling LBP (PR 1.7, 95%CI 1.1-2.5) at follow-up. No other associations were found between MRI abnormalities and subsequent outcome.
  
  
  CONCLUSIONS
  Our findings suggest that the MRI abnormalities examined are not major predictors of outcome in patients with LBP. They give no support to the use of MRI findings as a way of refining case definition for LBP in epidemiological research.
authors: MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK. dnc@mrc.soton.ac.uk.
authors: Philip
authors: P
authors: McNee
authors: James
authors: J
authors: Shambrook
authors: E Clare
authors: EC
authors: Harris
authors: Miranda
authors: M
authors: Kim
authors: Madeleine
authors: M
authors: Sampson
authors: Keith T
authors: KT
authors: Palmer
authors: David
authors: D
authors: Coggon
mesh_terms: D000328:Adult; D004185:Disability Evaluation; D006233:Persons with Disabilities; D004651:Employment; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D017116:Low Back Pain / Q000175:diagnosis* / Q000503:physiopathology* / Q000628:therapy; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D013131:Spine / Q000473:pathology / Q000601:surgery; D011795:Surveys and Questionnaires; D055815:Young Adult