title: Effect of tissue perfusion on microwave ablation: experimental in vivo study in porcine kidneys.
abstract: OBJECTIVE
  To determine the effect of tissue perfusion on microwave ablation lesions in an experimental in vivo study in porcine kidneys.
  
  
  METHODS
  Twelve kidneys of six pigs were studied. In each animal, two microwave ablations were created in one kidney without limitation of tissue perfusion (group 1). In the other kidney, two microwave ablations were performed with interruption of blood flow (group 2). All microwave ablations were performed with identical system parameters (eg, temperature control mode, ablation time of 80 s, and temperature of 110°C). The animals were euthanized 3 hours later. The kidneys were harvested and cut into 2-3-mm transverse slices. Microwave ablation zone dimensions (eg, length, width, and volume) and shape (eg, sphericity ratio) and corresponding variability were compared between groups.
  
  
  RESULTS
  Microwave ablation areas were significantly longer (41.6 mm ± 4.0 vs 34.2 mm ± 5.9; P < .01) and wider (16.6 mm ± 1.2 vs 12.2 mm ± 2.1; P < .001) in group 2 than in group 1. Similarly, microwave ablation volume was significantly greater in group 2 compared with group 1 (6.7 cm(3) ± 1.0 vs 3.3 cm(3) ± 1.2; P < .001). Ablation area shapes were similar between groups (sphericity ratio, 2.57 ± 0.42 vs 2.39 ± 0.34). Ablation area variabilities were also comparable between groups (volume variance of 1.32 vs 0.93; sphericity ratio variance of 0.18 vs 0.11).
  
  
  CONCLUSIONS
  After interruption of blood flow, microwave ablation areas are significantly larger than those achieved without limitation of tissue perfusion. Microwave ablation area shape and variability were comparable between study groups.
authors: Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany. christof.sommer@med.uni-heidelberg.de
authors: Christof M
authors: CM
authors: Sommer
authors: Vitali
authors: V
authors: Koch
authors: Bence
authors: B
authors: Pap
authors: Nadine
authors: N
authors: Bellemann
authors: Maria
authors: M
authors: Holzschuh
authors: Tobias
authors: T
authors: Gehrig
authors: Maxym
authors: M
authors: Shevchenko
authors: Florian U
authors: FU
authors: Arnegger
authors: Felix
authors: F
authors: Nickel
authors: Carolin
authors: C
authors: Mogler
authors: Sascha
authors: S
authors: Zelzer
authors: Hans P
authors: HP
authors: Meinzer
authors: Ulrike
authors: U
authors: Stampfl
authors: Hans U
authors: HU
authors: Kauczor
authors: Boris A
authors: BA
authors: Radeleff
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D017115:Catheter Ablation / Q000379:methods*; D007668:Kidney / Q000098:blood supply / Q000503:physiopathology* / Q000528:radiation effects*; D008872:Microwaves / Q000627:therapeutic use; D013552:Swine