title: Serum uric acid: a marker of metabolic syndrome and subclinical atherosclerosis in Korean men.
abstract: Serum uric acid (SUA) is a potential risk factor for atherosclerosis. We assessed the relationship between SUA and subclinical atherosclerosis in Korean men (n = 3010). Multidetector computed tomography (MDCT) and ultrasonographic measurements of coronary artery calcification (CAC) and carotid intima-media thickness (cIMT), respectively, are markers of subclinical atherosclerosis. Odds ratios (ORs) of CAC score and cIMT across SUA levels were 1.101 (P = .046) and 1.266 (P = .002), respectively, after adjustment for several variables. The independent association between CAC and cIMT was observed (OR = 1.231, P < .001). Serum uric acid was independently associated with metabolic syndrome (MetS) with an OR of 1.415 (P < .001). Metabolic syndrome was only independently associated with cIMT, with an OR of 2.103 (P = .003). High-sensitivity C-reactive protein was positively correlated with SUA (r = .125, P < .001). Serum uric acid level is independently associated with CAC, cIMT, and MetS in Korean men.
authors: Department of Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiaotong University, China. zhengyunzh@gmail.com
authors: Zhengyun
authors: Z
authors: Zhang
authors: Luqin
authors: L
authors: Bian
authors: Yoonho
authors: Y
authors: Choi
mesh_terms: D050197:Atherosclerosis / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D015415:Biomarkers / Q000097:blood*; D015992:Body Mass Index; D002114:Calcinosis / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D059168:Carotid Intima-Media Thickness; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D003331:Coronary Vessels; D004562:Electrocardiography; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000453:epidemiology*; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D016017:Odds Ratio; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D014527:Uric Acid