title: Anthraquinones from the roots of Knoxia valerianoides.
abstract: Five new 9,10-anthraquinones (1-5) were isolated from an ethanol extract of the roots of Knoxia valerianoides. Their structures including absolute configuration of 1 were determined by spectroscopic analysis. Compounds 4 and 5 showed moderate activity against nitrogen oxide production in macrophages induced by lipopolysaccharide, at 10(- 5) M, with inhibition ratios of 50.4 ± 3.6 and 41.7 ± 2.1%, respectively.
authors: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, and Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
authors: Feng
authors: F
authors: Zhao
authors: Su-Juan
authors: SJ
authors: Wang
authors: Sheng
authors: S
authors: Lin
authors: Cheng-Gen
authors: CG
authors: Zhu
authors: Shao-Peng
authors: SP
authors: Yuan
authors: Xiao-Yu
authors: XY
authors: Ding
authors: Zheng-Gang
authors: ZG
authors: Yue
authors: Yang
authors: Y
authors: Yu
authors: Bo
authors: B
authors: Liu
authors: Xiu-Li
authors: XL
authors: Wu
authors: Qi
authors: Q
authors: Hou
authors: Jian-Gong
authors: JG
authors: Shi
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D017737:Macrophages, Peritoneal / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D019666:Rubiaceae / Q000737:chemistry*
chemical_list: D000880:Anthraquinones; D004365:Drugs, Chinese Herbal; D008070:Lipopolysaccharides; D009569:Nitric Oxide