title: Post-reperfusion syndrome during isolated intestinal transplantation: outcome and predictors.
abstract: BACKGROUND
  Post-reperfusion syndrome (PRS) during isolated intestinal transplantation (ITx) is characterized by decreased systemic blood pressure, systemic vascular resistance, and cardiac output and by a moderate increased pulmonary arterial pressure. We hypothesize that the more severe PRS causes a poorer long-term outcome. The primary aim of this study was to determine the independent clinical predictors of intra-operative PRS, as well as to investigate the link between the severity of PRS and the intra-operative profiles and to examine the post-operative complications and their relationship with transplant outcome.
  
  
  METHODS
  This observational study was conducted on 27 patients undergoing isolated ITx in a single adult liver and multivisceral transplantation center. PRS was considered when the mean arterial blood pressure was 30% lower than the pre-unclamping value and lasted for at least one min within 10 min after unclamping.
  
  
  CONCLUSIONS
  The main results of this study can be summarized in two findings: in patients undergoing ITx, the duration of cold ischemia and the pre-operative glomerular filtration rate were independent predictors of PRS and the occurrence of intra-operative PRS was associated with significantly more frequent post-operative renal failure and early post-operative death.
authors: Department of Anesthesiology, Alma Mater Studiorum, University of Bologna, Bologna, Italy. sinianest@libero.it
authors: Antonio
authors: A
authors: Siniscalchi
authors: Alessandro
authors: A
authors: Cucchetti
authors: Zuzana
authors: Z
authors: Miklosova
authors: Augusto
authors: A
authors: Lauro
authors: Andrea
authors: A
authors: Zanoni
authors: Salvatore
authors: S
authors: Spedicato
authors: Enrico
authors: E
authors: Bernardi
authors: Lucia
authors: L
authors: Aurini
authors: Antonio D
authors: AD
authors: Pinna
authors: Stefano
authors: S
authors: Faenza
mesh_terms: D000293:Adolescent; D000328:Adult; D050377:Cold Ischemia / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D007410:Intestinal Diseases / Q000401:mortality / Q000601:surgery*; D007422:Intestines / Q000601:surgery / Q000637:transplantation*; D008297:Male; D008875:Middle Aged; D016377:Organ Transplantation / Q000009:adverse effects* / Q000401:mortality; D011183:Postoperative Complications; D011379:Prognosis; D051437:Renal Insufficiency / Q000209:etiology / Q000401:mortality; D015427:Reperfusion Injury / Q000209:etiology* / Q000401:mortality*; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D013577:Syndrome; D055815:Young Adult