title: Vaginal langerhans cells nonproductively transporting HIV-1 mediate infection of T cells.
abstract: Although implied by other models, proof that Langerhans cells (LCs) in the human vagina participate in dissemination of infectious human immunodeficiency virus type 1 (HIV-1) has been lacking. Here, we show that LCs migrate from HIV-1-exposed vaginal epithelia and pass infectious virus to CD4+ T cells without being productively infected themselves, and we point to a pathway that might enable HIV-1 to avoid degradation in vaginal LCs. Transport by migratory LCs to local lymphatics in a nonproductive but infectious form may aid HIV-1 in evasion of topical microbicides that target its intracellular productive life cycle.
authors: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., D3-100, Seattle, WA 98109-1024, USA.
authors: Lamar
authors: L
authors: Ballweber
authors: Barry
authors: B
authors: Robinson
authors: Allison
authors: A
authors: Kreger
authors: Michael
authors: M
authors: Fialkow
authors: Gretchen
authors: G
authors: Lentz
authors: M Juliana
authors: MJ
authors: McElrath
authors: Florian
authors: F
authors: Hladik
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000821:virology*; D002465:Cell Movement; D005260:Female; D015658:HIV Infections / Q000635:transmission* / Q000821:virology; D015497:HIV-1 / Q000254:growth & development* / Q000472:pathogenicity*; D006801:Humans; D007801:Langerhans Cells / Q000821:virology*; D014621:Vagina / Q000276:immunology* / Q000821:virology*