title: In search of epilepsy biomarkers in the immature brain: goals, challenges and strategies.
abstract: Epilepsy and seizures are very common in the early years of life and are often associated with significant morbidity and mortality. Identification of biomarkers for the early detection of epileptogenicity, epileptogenesis, comorbidities, disease progression and treatment implementation will be very important in implementing more effective therapies. This article summarizes the current needs in the search for new early life epilepsy-related biomarkers and discusses the candidate biomarkers that are under investigation, as well as the challenges associated with the identification and validation of these biomarkers.
authors: Saul R Korey Department of Neurology, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Kennedy Center, Room 306, Bronx, NY 10461, USA. aristea.galanopoulou@einstein.yu.edu
authors: Aristea S
authors: AS
authors: Galanopoulou
authors: Solomon L
authors: SL
authors: Moshé
mesh_terms: D000367:Age Factors; D000818:Animals; D015415:Biomarkers / Q000737:chemistry / Q000378:metabolism; D001921:Brain / Q000033:anatomy & histology / Q000254:growth & development* / Q000378:metabolism; D004195:Disease Models, Animal; D004285:Dogs; D004569:Electroencephalography; D004827:Epilepsy / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D051379:Mice; D051381:Rats; D011963:Receptors, GABA-A / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D012737:Sex Factors; D013997:Time Factors
chemical_list: D015415:Biomarkers; D011963:Receptors, GABA-A; D016194:Receptors, N-Methyl-D-Aspartate