title: Vitamin D-gene interactions in multiple sclerosis.
abstract: Vitamin D has been studied for over a century and its functions related to calcium homeostasis are well established. Over the last 30 years or so it has become increasingly clear that it has a wider role in physiology and, importantly, also in disease. Vitamin D deficiency has been linked to multiple sclerosis (MS); however the molecular mechanisms of this association were poorly understood. Recent technological advances have provided major insights as to how vitamin D may exert its role, particularly through the actions of the vitamin D receptor (VDR). In this review we aim to highlight the importance of the interaction between vitamin D and MS associated genes which provide a biological basis for the association between vitamin D and MS risk.
authors: Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford, OX3 7BN, UK.
authors: Antonio J
authors: AJ
authors: Berlanga-Taylor
authors: Giulio
authors: G
authors: Disanto
authors: George C
authors: GC
authors: Ebers
authors: Sreeram V
authors: SV
authors: Ramagopalan
mesh_terms: D000818:Animals; D015897:Comorbidity / Q000639:trends; D020022:Genetic Predisposition to Disease / Q000235:genetics; D055106:Genome-Wide Association Study; D006801:Humans; D009103:Multiple Sclerosis / Q000453:epidemiology* / Q000235:genetics* / Q000378:metabolism; D018167:Receptors, Calcitriol / Q000235:genetics / Q000378:metabolism*; D014807:Vitamin D / Q000378:metabolism*; D014808:Vitamin D Deficiency / Q000453:epidemiology* / Q000235:genetics* / Q000378:metabolism
chemical_list: D018167:Receptors, Calcitriol; D014807:Vitamin D