title: [What do we know about pathogenesis of psoriasis?].
abstract: Psoriasis has been considered as a disease of the keratinocytes, or an autoimmune disease. According to the current view, altered interaction of the immune system with epithelial cells and mediators of the skin is essential in psoriasis. In genetically predisposed subjects, psoriasis may appear as a result of external factors, but no antigen or autoantigen triggering the inflammation has been identified. Genetic factors have a particularly strong effect in the so-called type I psoriasis. During the last few years, genome research has revealed a number of new susceptibility genes for psoriasis.
authors: HUS Iho- ja allergiasairaala, PL 160, 00029 HUS.
authors: Tarja
authors: T
authors: Mälkonen
authors: Sari
authors: S
authors: Suomela
mesh_terms: D020022:Genetic Predisposition to Disease; D006801:Humans; D011565:Psoriasis / Q000235:genetics* / Q000276:immunology*