title: Post term dietary-induced changes in DHA and AA status relate to gains in weight, length, and head circumference in preterm infants.
abstract: Preterms need supplementation with docosahexaenoic (DHA) and arachidonic (AA) acids to prevent steep postnatal declines. Associations between growth and erythrocyte (RBC) DHA and AA were studied in 139 preterms (51% male, gestational age 30.3±1.5 weeks, birth weight 1341±288g) fed human milk with breast milk fortifier or preterm formula until term, followed by postdischarge formula (PDF; n=52, 0.4% DHA, 0.4% AA), term formula (TF; n=41, 0.2% DHA, 0.2% AA), or human milk (HM; n=46). At six months, PDF resulted in higher RBC-DHA than TF and HM, while RBC-AA was higher than TF, but similar to HM. There were no between-group differences in growth between term and six months. RHC-DHA related positively with gain in weight and length and negatively with gain in head circumference. RBC-AA related positively with gain in head circumference and negatively with gain in weight and length. In conclusion, PDF with higher DHA and AA than TF may promote postnatal growth of preterms.
authors: Department of Pediatrics, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands. m.vandelagemaat@vumc.nl
authors: Monique
authors: M
authors: van de Lagemaat
authors: Joost
authors: J
authors: Rotteveel
authors: Frits A J
authors: FA
authors: Muskiet
authors: Anne
authors: A
authors: Schaafsma
authors: Harrie N
authors: HN
authors: Lafeber
mesh_terms: D016718:Arachidonic Acid / Q000008:administration & dosage* / Q000378:metabolism; D001827:Body Height; D004281:Docosahexaenoic Acids / Q000008:administration & dosage* / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D006257:Head / Q000033:anatomy & histology*; D006801:Humans; D007223:Infant; D041943:Infant Formula; D007231:Infant, Newborn; D007234:Infant, Premature / Q000254:growth & development*; D008297:Male; D016896:Treatment Outcome; D015430:Weight Gain
chemical_list: D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid