title: Nucleic acid-templated energy transfer leading to a photorelease reaction and its application to a system displaying a nonlinear response.
abstract: The photocleavage of a nitrobenzyl-type linker (NPPOC) at 405 nm wavelength was enabled by nucleic acid-templated energy transfer from a sensitizer (thioxanthenone) to the linker. This strategy was used to release profluorescent rhodamine, which facilitated monitoring of the reaction via fluorescence measurement in a nonoverlapping window with the sensitizer/photocleavage reaction. The rate acceleration of the templated reaction was greater than 20-fold over the background reaction. The templated reaction was used in conjunction with strand displacement to design four-component systems that responded to an analyte (DNA). Programming a specific hierarchical relationship among the four components enabled the design of a system that responded first positively and then negatively to increasing levels of an analyte.
authors: Institut de Science et Ingénierie Supramoléculaires (UMR 7006), Université de Strasbourg-CNRS, 8 allée Gaspard Monge, F67000 Strasbourg, France.
authors: Manuel
authors: M
authors: Röthlingshöfer
authors: Katarzyna
authors: K
authors: Gorska
authors: Nicolas
authors: N
authors: Winssinger
mesh_terms: D004735:Energy Transfer; D009696:Nucleic Acids / Q000737:chemistry*; D055668:Photochemical Processes; D012235:Rhodamines / Q000737:chemistry; D013892:Thioxanthenes / Q000737:chemistry
chemical_list: D009696:Nucleic Acids; D012235:Rhodamines; D013892:Thioxanthenes