title: Aggressive peripheral CD70-positive T-cell lymphoma associated with severe chronic active EBV infection.
abstract: Severe chronic active Epstein-Barr virus infection (CAEBV) in T or NK cells is a rare complication of latent EBV infection. CAEBV associated T-cell lymphoproliferative disease (LPD) consists of polyclonal lesions as well as aggressive lymphomas. Here, we report such a patient. In addition, we show that this primary CAEBV associated T-cell lymphoma expresses CD70 and is sensitive to killing by CD70-specific T cells, identifying CD70 as a potential immunotherapeutic target for CAEBV-associated T-cell lymphoma.
authors: Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, The Methodist Hospital, Houston, Texas 77030, USA.
authors: Donald R
authors: DR
authors: Shaffer
authors: Andrea M
authors: AM
authors: Sheehan
authors: Zhongzhen
authors: Z
authors: Yi
authors: Cheryl C
authors: CC
authors: Rodgers
authors: Catherine M
authors: CM
authors: Bollard
authors: Malcolm K
authors: MK
authors: Brenner
authors: Cliona M
authors: CM
authors: Rooney
authors: Helen E
authors: HE
authors: Heslop
authors: Stephen
authors: S
authors: Gottschalk
mesh_terms: D053282:CD27 Ligand / Q000378:metabolism*; D002675:Child, Preschool; D002908:Chronic Disease; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000276:immunology / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016399:Lymphoma, T-Cell / Q000209:etiology / Q000276:immunology / Q000821:virology*; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D053282:CD27 Ligand