title: Nuclear architecture: the cell biology of a laminopathy.
abstract: Lamin mutations cause muscular dystrophies, but the mechanism is unclear. A new study shows that lamin mutant worms display muscle-specific defects linked to altered subnuclear localization of heterochromatin, leading to altered gene expression.
authors: Department of Molecular Biosciences, Northwestern University, Hogan 2100, Evanston, IL 60201, USA. j-brickner@northwestern.edu
authors: Jason H
authors: JH
authors: Brickner
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D006801:Humans; D007797:Laminin / Q000378:metabolism*; D020389:Muscular Dystrophy, Emery-Dreifuss / Q000235:genetics*; D017354:Point Mutation
chemical_list: D029742:Caenorhabditis elegans Proteins; C570326:LMN-1 protein, C elegans; D007797:Laminin