title: Synthesis of a benzomacrolactone-based somatostatin mimetic.
abstract: The benzomacrolactone is a framework found in numerous natural products. The synthesis of an orthogonally functionalized benzomacrolactone from D-glucosamine and a salicylic acid derivative is described. This macrolactone was used for the synthesis of a somatostatin mimetic that has submicromolar affinity for the human somatostatin receptor 4 (hSSTR4).
authors: School of Chemistry, National University of Ireland Galway, University Road, Galway, Ireland.
authors: Jian
authors: J
authors: Zhou
authors: Marie-Christine
authors: MC
authors: Matos
authors: Paul V
authors: PV
authors: Murphy
mesh_terms: D001593:Benzyl Compounds / Q000138:chemical synthesis* / Q000378:metabolism; D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000378:metabolism; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis* / Q000378:metabolism; D015394:Molecular Structure; D017481:Receptors, Somatostatin / Q000378:metabolism; D013004:Somatostatin / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D001593:Benzyl Compounds; D007783:Lactones; D017481:Receptors, Somatostatin; C098681:somatostatin receptor subtype-4; D013004:Somatostatin