title: Intranasal application of S. epidermidis prevents colonization by methicillin-resistant Staphylococcus aureus in mice.
abstract: Methicillin-resistant S. aureus emerged in recent decades to become a leading cause of infection worldwide. Colonization with MRSA predisposes to infection and facilitates transmission of the pathogen; however, available regimens are ineffective at preventing MRSA colonization. Studies of human nasal flora suggest that resident bacteria play a critical role in limiting S. aureus growth, and prompted us to query whether application of commensal resident bacteria could prevent nasal colonization with MRSA. We established a murine model system to study this question, and showed that mice nasally pre-colonized with S. epidermidis became more resistant to colonization with MRSA. Our study suggests that application of commensal bacteria with antibiotics could represent a more effective strategy to prevent MRSA colonization.
authors: Division of Infectious Diseases, Department of Pediatrics, Research Division of Immunology, Department of Biomedical Sciences, and the Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
authors: Bonggoo
authors: B
authors: Park
authors: Tadayuki
authors: T
authors: Iwase
authors: George Y
authors: GY
authors: Liu
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000254:growth & development*; D051379:Mice; D009666:Nose / Q000382:microbiology; D013203:Staphylococcal Infections / Q000382:microbiology / Q000517:prevention & control; D013212:Staphylococcus epidermidis / Q000502:physiology*