title: Manganese superoxide dismutase and glutathione peroxidase as prognostic markers in patients with buccal mucosal squamous cell carcinomas.
abstract: BACKGROUND
  We investigated the relationship of the immunohistochemical expression status of manganese superoxide dismutase (MnSOD), catalase, glutathione peroxidase (GPx), and myeloperoxidase (MPO) in buccal mucosal squamous cell carcinoma (SCC) with clinicopathologic parameters and prognosis.
  
  
  METHODS
  The expression status of MnSOD, GPx, catalase, and MPO was evaluated by immunohistochemistry in a series of 216 surgically resected buccal mucosal SCC specimens, using tissue microarray slides.
  
  
  RESULTS
  MnSOD, GPx, catalase, and MPO were commonly expressed in buccal mucosal SCC. The high expression level of MnSOD was associated with better disease-specific survival (p = .009), especially for patients in moderate or poor cell differentiation (p = .045), pathologic stage I (p = .002) and postoperative radiotherapy (p = .048). The high expression level of GPx was also correlated with better disease-specific survival (p = .042), especially for patients in pathologic stage IV (p = .010) and postoperative radiotherapy (p = .018).
  
  
  CONCLUSIONS
  MnSOD and GPx are significant prognostic factors for favorable survival in patients with buccal mucosal SCC.
authors: Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, Republic of China.
authors: Ting-Ying
authors: TY
authors: Fu
authors: Yu-Yi
authors: YY
authors: Hou
authors: Sau-Tung
authors: ST
authors: Chu
authors: Ching-Feng
authors: CF
authors: Liu
authors: Cheng-Hui
authors: CH
authors: Huang
authors: Hung-Chih
authors: HC
authors: Chen
authors: Michael
authors: M
authors: Hsiao
authors: Pei-Jung
authors: PJ
authors: Lu
authors: Jyh-Seng
authors: JS
authors: Wang
authors: Luo-Ping
authors: LP
authors: Ger
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D014408:Biomarkers, Tumor / Q000032:analysis / Q000378:metabolism*; D001707:Biopsy, Needle; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D005979:Glutathione Peroxidase / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology*; D009062:Mouth Neoplasms / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D009367:Neoplasm Staging; D009195:Peroxidase / Q000032:analysis / Q000378:metabolism; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012494:Sampling Studies; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D013482:Superoxide Dismutase / Q000032:analysis / Q000378:metabolism*; D016019:Survival Analysis; D016610:Tissue Embedding; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D009195:Peroxidase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase