title: Effective everolimus treatment of inoperable, life-threatening subependymal giant cell astrocytoma and intractable epilepsy in a patient with tuberous sclerosis complex.
abstract: We present successful everolimus treatment of a huge subependymal giant cell astrocytoma in a 10-year old boy with tuberous sclerosis complex. The patient underwent several partial tumor resections complicated by intraoperative cardiac arrest. The tumor has been regrowing and produced severe clinical symptoms. Everolimus treatment resulted in marked tumor regression, significant improvement in patient's ambulation and cessation of seizures. Moreover, the therapy was well tolerated. These findings indicate that everolimus treatment should be considered as a therapeutic option alternative to surgery in patients with tuberous sclerosis complex.
authors: Department of Oncology, The Children's Memorial Health Institute, Warsaw, Poland.
authors: Marta
authors: M
authors: Perek-Polnik
authors: Sergiusz
authors: S
authors: Jóźwiak
authors: Elżbieta
authors: E
authors: Jurkiewicz
authors: Danuta
authors: D
authors: Perek
authors: Katarzyna
authors: K
authors: Kotulska
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001254:Astrocytoma / Q000188:drug therapy* / Q000473:pathology; D002551:Cerebral Ventricle Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002648:Child; D004827:Epilepsy / Q000188:drug therapy* / Q000209:etiology; D000068338:Everolimus; D006801:Humans; D008297:Male; D020123:Sirolimus / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014402:Tuberous Sclerosis / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents; D000068338:Everolimus; D020123:Sirolimus