title: Dopaminergic striatal innervation predicts interlimb transfer of a visuomotor skill.
abstract: We investigated whether dopamine influences the rate of adaptation to a visuomotor distortion and the transfer of this learning from the right to the left limb in human subjects. We thus studied patients with Parkinson disease as a putative in vivo model of dopaminergic denervation. Despite normal adaptation rates, patients showed a reduced transfer compared with age-matched healthy controls. The magnitude of the transfer, but not of the adaptation rate, was positively predicted by the values of dopamine-transporter binding of the right caudate and putamen. We conclude that striatal dopaminergic activity plays an important role in the transfer of visuomotor skills.
authors: Università degli Studi di Milano, Dipartimento di Fisiologia Umana, 20133 Milano, Italy. iuisaias@yahoo.it
authors: Ioannis U
authors: IU
authors: Isaias
authors: Clara
authors: C
authors: Moisello
authors: Giorgio
authors: G
authors: Marotta
authors: Mauro
authors: M
authors: Schiavella
authors: Margherita
authors: M
authors: Canesi
authors: Bernardo
authors: B
authors: Perfetti
authors: Paolo
authors: P
authors: Cavallari
authors: Gianni
authors: G
authors: Pezzoli
authors: M Felice
authors: MF
authors: Ghilardi
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000328:Adult; D000368:Aged; D001931:Brain Mapping; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism; D005121:Extremities / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009048:Motor Skills / Q000502:physiology*; D010300:Parkinson Disease / Q000473:pathology / Q000503:physiopathology; D010775:Photic Stimulation / Q000379:methods; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D014163:Transfer, Psychology / Q000502:physiology*; D014326:Tropanes / Q000378:metabolism
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane; D004298:Dopamine