title: Methods for detection of circulating tumour cells and their clinical value in cancer patients.
abstract: Currently available analytical methods enable             identification, detection and characterization of             circulating tumour cells in the peripheral blood and             disseminated tumour cells in the bone marrow of             breast cancer patients. About 0.01 % of the circulating             tumour cells observed in the blood are able to             form metastases. Therefore, they could be used for             estimation of the risk for metastatic relapse, as a diagnostic             tool for patient stratification, early determination             of the therapy failure, or potential risk of resistance             to the given therapeutic intervention. New             therapeutic molecular targets could be identified for             management of cancer patients using circulating tumour             cell detection. The following review summarizes             introduced methods of circulating tumour cell             detection and their possible application in clinics.
authors: Laboratory of Clinical Immunology and Allergology, Institute of Clinical Biochemistry and Laboratory Diagnostics, Charles University in Prague, Czech Republic. veronika.mikulova(@)vfn.cz
authors: V
authors: V
authors: Mikulová
authors: K
authors: K
authors: Kološtová
authors: T
authors: T
authors: Zima
mesh_terms: D006801:Humans; D007150:Immunohistochemistry; D018189:Immunomagnetic Separation; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D009360:Neoplastic Cells, Circulating / Q000378:metabolism / Q000473:pathology*; D020133:Reverse Transcriptase Polymerase Chain Reaction