title: Experimental hyperlipemia induces insulin resistance in cats.
abstract: The effect of experimental hyperlipemia on insulin sensitivity was evaluated in seven healthy cats. Serum triglyceride and free fatty acid concentrations were significantly (P<0.05) higher when lipid-heparin was administered (2,894 ± 1,526 mg/dl and 4.54 ± 0.70 mEq/l, respectively) than when saline was administered (70 ± 42 mg/dl and 0.22 ± 0.08 mEq/l, respectively). A glucose clamp test revealed that the mean glucose infusion rate when lipid-heparin was administered (5.80 ± 0.67 mg/kg/min) was significantly (P<0.05) lower than when saline was administered (8.52 ± 1.83 mg/kg/min). These results suggest that experimental hyperlipemia induced insulin resistance in the healthy cats.
authors: Laboratory of Veterinary Pharmacotherapeutics, Faculty of Agriculture, Tottori University, 4–101 Koyama-minami, Tottori 680–5883, Japan. nnishii@muses.tottori-u.ac.jp
authors: Naohito
authors: N
authors: Nishii
authors: Haruka
authors: H
authors: Maeda
authors: Yusuke
authors: Y
authors: Murahata
authors: Aya
authors: A
authors: Matsuu
authors: Yoshiaki
authors: Y
authors: Hikasa
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002415:Cats; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006949:Hyperlipidemias / Q000097:blood*; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D014280:Triglycerides