title: OX40 ligand levels and high-sensitivity C-reactive protein levels in blood from local coronary plaque and the femoral artery in patients with acute coronary syndrome or stable angina.
abstract: OX40 ligand (OX40L) and high-sensitivity C-reactive protein (hs-CRP) play important roles in the pathogenesis of atherosclerosis. In this study, consecutive patients with acute coronary syndrome (ACS; n = 90) or stable angina (SA; n = 40) and healthy control subjects (n  = 50) were evaluated to assess plasma OX40L and serum hs-CRP levels in local coronary plaque and the femoral artery. OX40L and hs-CRP levels in the femoral artery were significantly higher in patients with ACS compared with controls. OX40L and hsCRP levels in local coronary plaque (OX40L(c)  and hs-CRP(c), respectively) were significantly higher in ACS than in SA patients. OX40L and hs-CRP levels were positively correlated with each other and were also correlated with fibrinogen levels. The number of complex lesions was correlated with OX40L(c) and hs-CRP(c)  levels. It is concluded that the OX40L(c) level was highly sensitive for evaluating the inflammatory response in ACS and elevated levels of OX40L(c) may be a valuable predictive marker for increased risk of atherosclerotic progression in ACS patients.
authors: Department of Cardiology, Provincial Hospital affiliated to Shandong University, Jinan, China.
authors: J Z
authors: JZ
authors: Shi
authors: L Y
authors: LY
authors: Wang
authors: Y
authors: Y
authors: Zhu
authors: C Y
authors: CY
authors: Zhao
authors: W
authors: W
authors: Liu
authors: S L
authors: SL
authors: Jiang
authors: H W
authors: HW
authors: You
authors: Y
authors: Y
authors: Wang
authors: F Y
authors: FY
authors: Xu
authors: Y S
authors: YS
authors: Tang
authors: L Q
authors: LQ
authors: Cui
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000175:diagnosis; D060050:Angina, Stable / Q000097:blood* / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005263:Femoral Artery / Q000378:metabolism* / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D053278:OX40 Ligand / Q000097:blood*; D058226:Plaque, Atherosclerotic / Q000097:blood* / Q000175:diagnosis; D011379:Prognosis; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D053278:OX40 Ligand; D002097:C-Reactive Protein