title: Evolutionary mechanisms of retroviral persistence.
abstract: Retroviruses are known to exhibit remarkable genomic pliancy, a capacity that has been attributed to one or more error prone steps in the viral replication cycle. However, increasing evidence suggests that such error represents a key element in viral survival, as exemplified by studies on virus immune evasion, shifts of cellular tropism, and anatomic compartmentalization, which facilitate persistent virus reservoirs. Understanding the dynamic mechanisms that contribute to the establishment and maintenance of retroviral persistence is critical toward the goal of attaining HIV-1 eradication.
authors: Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA. jwhitne2@bidmc.harvard.edu
authors: James B
authors: JB
authors: Whitney
authors: So-Yon
authors: SY
authors: Lim
authors: Mark A
authors: MA
authors: Wainberg
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D005075:Biological Evolution; D004197:Disease Reservoirs / Q000821:virology; D024882:Drug Resistance, Viral; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D006801:Humans; D014766:Viremia; D017735:Virus Latency; D014779:Virus Replication
chemical_list: D019380:Anti-HIV Agents