title: Accuracy of the reconstruction of the crystalline lens gradient index with optimization methods from ray tracing and Optical Coherence Tomography data.
abstract: The accuracy of the reconstruction of the Gradient Refractive Index (GRIN) of the crystalline lens from optimization methods was evaluated. Different input data, including direction cosines of deflected rays, ray impacts obtained from ray tracing and optical path differences from Optical Coherence Tomography (OCT) were studied. Three different GRIN models were analyzed. The experimental errors of the different experimental input data were estimated from comparisons of measurements and simulations using artificial lenses of known geometries. The experimental errors in the surfaces shape measurement and the influence of the number of rays were also considered. OCT-based input data produced the most accurate GRIN reconstructions. We found that optimization methods (combining global and local search algorithms) allow GRIN reconstructions with acceptable accuracies for moderate noise level.
authors: Instituto de Óptica Daza de Valdés, Consejo Superior de Investigaciones Científicas, C/ Serrano 121, 28006 Madrid Spain. alberto@io.cfmac.csic.es
authors: Alberto
authors: A
authors: de Castro
authors: Sergio
authors: S
authors: Barbero
authors: Sergio
authors: S
authors: Ortiz
authors: Susana
authors: S
authors: Marcos
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007908:Lens, Crystalline / Q000033:anatomy & histology*; D012031:Refractometry / Q000379:methods*; D041623:Tomography, Optical Coherence / Q000379:methods*