title: Estimation of Tc-99m MAG3 clearance using camera-based methods without blood sampling.
abstract: OBJECTIVE
  To establish camera-based methods for estimating Tc-99m mercaptoacetyltriglycine (MAG3) clearance without blood sampling.
  
  
  METHODS
  The results of renal scintigraphy with Tc-99m MAG3 obtained from 160 patients were analyzed retrospectively. Eight renogram parameters were calculated for each patient based on the area under the renogram (area method) and slope of the renogram (slope method) using different periods for analysis (1-2 and 1-2.5 minutes for the area method; 0.5-1.5 and 0.5-2 minutes for the slope method) and different backgrounds for subtraction (perirenal and subrenal backgrounds). The 8 parameters were then correlated with MAG3 clearance measured by the single-sample methods proposed by Russell et al and Bubeck et al to determine the equation for the conversion of renogram parameters to clearance.
  
  
  RESULTS
  All 8 renogram parameters were highly correlated with clearance measured by the single-sample methods, and the obtained equations enabled the estimation of clearance from image data. Selection between the area and slope methods, between different periods for analysis, or between perirenal and subrenal backgrounds did not cause large differences in the estimation.
  
  
  CONCLUSIONS
  The camera-based methods determined in the present study allow the estimation of MAG3 clearance with acceptable accuracy.
authors: Department of Diagnostic Radiology, Kitasato University School of Medicine, Sagamihara, Japan. inoueys34@gmail.com
authors: Yusuke
authors: Y
authors: Inoue
authors: Kuni
authors: K
authors: Ohtomo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001800:Blood Specimen Collection / Q000379:methods*; D005260:Female; D015902:Gamma Cameras; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011866:Radioisotope Renography / Q000295:instrumentation*; D017263:Technetium Tc 99m Mertiatide / Q000493:pharmacokinetics*; D055815:Young Adult
chemical_list: D017263:Technetium Tc 99m Mertiatide