title: In vitro anti-HMPV activity of meroditerpenoids from marine alga Stypopodium zonale (Dictyotales).
abstract: In this paper, we evaluated the antiviral activity against HMPV replication of crude extract of the marine algae Stypopodium zonale and of two meroditerpenoids obtained from it, atomaric acid and epitaondiol, and a methyl ester derivative of atomaric acid. Their selectivity indexes were 20.78, >56.81, 49.26 and 12.82, respectively. Compared to ribavirin, the substances showed a relatively low cytotoxicity on LLC-MK2 cells, with a significant antiviral activity, inhibiting at least 90% of viral replication in vitro, which demonstrates the potential of these marine natural products to combat infections caused by HMPV in vitro.
authors: Laboratório Experimental de Drogas Antivirais e Citotóxicas (LEDAC), Departamento de Virologia do, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), CCS, Bloco I, Caixa Postal 68040, 21941-590 Rio de Janeiro, RJ, Brasil.
authors: Gabriella
authors: G
authors: Mendes
authors: Angélica Ribeiro
authors: AR
authors: Soares
authors: Lorena
authors: L
authors: Sigiliano
authors: Fernanda
authors: F
authors: Machado
authors: Carlos
authors: C
authors: Kaiser
authors: Nelilma
authors: N
authors: Romeiro
authors: Lísia
authors: L
authors: Gestinari
authors: Norma
authors: N
authors: Santos
authors: Maria Teresa Villela
authors: MT
authors: Romanos
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology*; D008253:Macaca mulatta; D029121:Metapneumovirus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D000459:Phaeophyceae; D012254:Ribavirin / Q000494:pharmacology; D013729:Terpenes / Q000737:chemistry / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D004224:Diterpenes; D013729:Terpenes; C570614:atomaric acid; D012254:Ribavirin; C094446:epitaondiol