title: Guillain-Barré syndrome associated with the D222E variant of the 2009 pandemic influenza A (H1N1) virus: case report and review of the literature.
abstract: Guillain-Barré syndrome (GBS) is an acute immune-mediated disorder of the peripheral nervous system and a triggering infectious event is often reported in the weeks before the disease onset. Influenza viruses have been associated with Guillain-Barré syndrome (GBS), both after infection and, in rare cases, after vaccination. However, GBS has rarely reported to be a neurological complication of the recent pandemic influenza A(H1N1) 2009 virus infections. Here we describe the case of a young man, who developed acute severe motor inflammatory demyelinating polyradiculoneuropathy during influenza A(H1N1)2009 infection. Peculiar features are the findings of a mutated haemagglutinin gene (D222E variant), which has never previously been associated with neurological involvement, and the almost simultaneous appearance of respiratory infectious and immune-mediated neurological symptoms. Moreover we review the clinical presentation, laboratory findings and outcome of influenza-related GBS.
authors: Unit of General Neurology, Institute of Neurology Fondazione IRCCS C.Mondino, Pavia, Italy. andrea.cortese@mondino.it
authors: Andrea
authors: A
authors: Cortese
authors: Fausto
authors: F
authors: Baldanti
authors: Eleonora
authors: E
authors: Tavazzi
authors: Livio
authors: L
authors: Carnevale
authors: Lorenzo
authors: L
authors: Minoli
authors: Alessandro
authors: A
authors: Lozza
authors: Enrico
authors: E
authors: Marchioni
mesh_terms: D000328:Adult; D004279:DNA, Viral / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics*; D020275:Guillain-Barre Syndrome / Q000453:epidemiology* / Q000821:virology*; D006801:Humans; D015994:Incidence; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics*; D007251:Influenza, Human / Q000453:epidemiology* / Q000821:virology*; D008297:Male; D058873:Pandemics
chemical_list: D004279:DNA, Viral