title: Computerized morphometry as an aid in distinguishing recurrent versus nonrecurrent meningiomas.
abstract: OBJECTIVE
  To use novel digital and morphometric methods to identify variables able to better predict the recurrence of intracranial meningiomas.
  
  
  METHODS
  Histologic images from 30 previously diagnosed meningioma tumors that recurred over 10 years of follow-up were consecutively selected from the Rambam Pathology Archives. Images were captured and morphometrically analyzed. Novel algorithms of digital pattern recognition using Fourier transformation and fractal and nuclear texture analyses were applied to evaluate the overall growth pattern complexity of the tumors, as well as the chromatin texture of individual tumor nuclei. The extracted parameters were then correlated with patient prognosis.
  
  
  RESULTS
  Kaplan-Meier analyses revealed statistically significant associations between tumor morphometric parameters and recurrence times. Tumors with less nuclear orientation, more nuclear density, higher fractal dimension, and less regular chromatin textures tended to recur faster than those with a higher degree of nuclear order, less pattern complexity, lower density, and more homogeneous chromatin nuclear textures (p < 0.01).
  
  
  CONCLUSIONS
  To our knowledge, these digital morphometric methods were used for the first time to accurately predict tumor recurrence in patients with intracranial meningiomas. The use of these methods may bring additional valuable information to the clinician regarding the optimal management of these patients.
authors: Department of Pathology and Oncology, Rambam Health Care Campus, Legacy Heritage Clinical Research Institute at Ram-bam, and Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
authors: Shawna
authors: S
authors: Noy
authors: Euvgeni
authors: E
authors: Vlodavsky
authors: Geula
authors: G
authors: Klorin
authors: Karen
authors: K
authors: Drumea
authors: Ofer
authors: O
authors: Ben Izhak
authors: Eli
authors: E
authors: Shor
authors: Edmond
authors: E
authors: Sabo
mesh_terms: D000368:Aged; D000465:Algorithms; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis*; D008579:Meningioma / Q000175:diagnosis*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis; D011379:Prognosis