title: [A family-based association study of FXYD6 gene polymorphisms and schizophrenia].
abstract: OBJECTIVE
  To study the association between the single nucleotide polymorphisms (SNPs) in FXYD6 gene and schizophrenia in a family-trios population.
  
  
  METHODS
  Six SNPs (rs10790212, rs11544201, rs555577, rs1815774, rs4938446 and rs497768) in the FXYD6 gene were genotyped by allele-specific PCR method in 101 nuclear families, and transmission disequilibrium test (TDT) was performed.
  
  
  RESULTS
  SNPs rs10790212 and rs11544201 showed significant association with schizophrenia (P<0.05). Furthermore, significant association of schizophrenia with the haplotype rs10790212-rs11544201 was found (P<0.05).
  
  
  CONCLUSIONS
  FXYD6 gene might play an important role in schizophrenia susceptibility and functional analysis of FXYD6 are needed.
authors: Department of Genetics and Molecular Biology, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi, People's Republic of China.
authors: Li-zi
authors: LZ
authors: Jiao
authors: Bing
authors: B
authors: Wang
authors: Xiao-rong
authors: XR
authors: Niu
authors: Xu-dong
authors: XD
authors: Ma
authors: Jian-peng
authors: JP
authors: Li
authors: Bo
authors: B
authors: Shen
authors: Yan-li
authors: YL
authors: Huang
authors: Huan
authors: H
authors: Zhang
authors: Rui
authors: R
authors: Zhang
authors: Jie
authors: J
authors: Ma
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D007473:Ion Channels / Q000235:genetics*; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D055815:Young Adult
chemical_list: C531119:FXYD6 protein, human; D007473:Ion Channels