title: A versatile synthetic approach to grandisol monoterpene pheromone.
abstract: A versatile and efficient synthetic procedure for the grandisol pheromone library has been established. The key feature of our synthesis involves a versatile and highly regioselective Pd(0)-catalyzed intramolecular allylic alkylation for the key cyclobutane skeleton of grandisol. In this connection, the concise synthesis of (±)-grandisol as well as mechanism study of Pd(0)-catalyzed regioselective cyclization as a key reaction have also been accomplished.
authors: College of Pharmacy, Seoul National University, Seoul 151-742, Korea.
authors: Young Taek
authors: YT
authors: Han
authors: Nam-Jung
authors: NJ
authors: Kim
authors: Jong-Wha
authors: JW
authors: Jung
authors: Hwayoung
authors: H
authors: Yun
authors: Sujin
authors: S
authors: Lee
authors: Young-Ger
authors: YG
authors: Suh
mesh_terms: D000478:Alkylation; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D012724:Sex Attractants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014835:Volatilization
chemical_list: D012724:Sex Attractants; D013729:Terpenes; D010165:Palladium; C013009:grandisol