title: A case of selective mutism in an 8-year-old girl with thalassaemia major after bone marrow transplantation.
abstract: Selective mutism is rare with a prevalence below 1% in the general population, but a higher prevalence in populations at risk (children with speech retardation, migration). Evidence for treatment strategies is hardly available. This case report provides information on the treatment of selective mutism in an 8-year-old girl with preexisting thalassaemia major. As medications she received penicillin prophylaxis (500000 IE/d) and deferasirox (Exjade; 20-25mg/kg/d), an iron chelator. The preexisting somatic disease and treatment complicated the treatment, as there are no data about pharmacological combination therapy. Psychotherapy in day treatment, supported by the use of the SSRI fluoxetine (10 mg), led to a decrease in the selective mutism score from 33 to 12 points, GAF improved by 21 points. Mean levels of fluoxetine plus norfluoxetine were 287.8 ng/ml without significant level fluctuations.
authors: P L
authors: PL
authors: Plener
authors: S A
authors: SA
authors: Gatz
authors: C
authors: C
authors: Schuetz
authors: A G
authors: AG
authors: Ludolph
authors: M
authors: M
authors: Kölch
mesh_terms: D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000523:psychology*; D002648:Child; D002673:Child, Hospitalized / Q000523:psychology*; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use; D006801:Humans; D009155:Mutism / Q000188:drug therapy / Q000523:psychology* / Q000628:therapy; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D016896:Treatment Outcome; D017086:beta-Thalassemia / Q000188:drug therapy / Q000523:psychology* / Q000628:therapy
chemical_list: D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors