title: Obstetric antiphospholipid syndrome.
abstract: Antiphospholipid syndrome (APS) in pregnancy has a serious impact on maternal and fetal morbidity. It causes recurrent pregnancy miscarriage and it is associated with other adverse obstetric findings like preterm delivery, intrauterine growth restriction, preeclampsia, HELLP syndrome and others. The 2006 revised criteria, which is still valid, is used for APS classification. Epidemiology of obstetric APS varies from one population group to another largely due to different inclusion criteria and lack of standardization of antibody detection methods. Treatment is still controversial. This topic should include a multidisciplinary team and should be individualized. Success here is based on strict control and monitoring throughout pregnancy and even in the preconception and postpartum periods. Further research in this field and unification of criteria are required to yield better therapeutic strategies in the future.
authors: Unit of Rheumatic and Autoimmune Diseases UNERA, Lupus Center, Mont Sinai Hospital, Cuenca, Ecuador. claudiogalarza@hotmail.com
authors: Claudio
authors: C
authors: Galarza-Maldonado
authors: Maria R
authors: MR
authors: Kourilovitch
authors: Oscar M
authors: OM
authors: Pérez-Fernández
authors: Mariana
authors: M
authors: Gaybor
authors: Christian
authors: C
authors: Cordero
authors: Sonia
authors: S
authors: Cabrera
authors: Nikolai F
authors: NF
authors: Soroka
mesh_terms: D000026:Abortion, Habitual / Q000453:epidemiology; D000818:Animals; D017152:Antibodies, Antiphospholipid / Q000276:immunology*; D000920:Antibody-Dependent Cell Cytotoxicity; D016736:Antiphospholipid Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology; D001241:Aspirin / Q000627:therapeutic use; D001777:Blood Coagulation / Q000187:drug effects; D004195:Disease Models, Animal; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007167:Immunotherapy / Q000639:trends; D051379:Mice; D057285:Precision Medicine; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy / Q000191:economics / Q000453:epidemiology / Q000276:immunology
chemical_list: D017152:Antibodies, Antiphospholipid; D006493:Heparin; D001241:Aspirin