title: Association of serum leptin levels with progression of diabetic kidney disease in patients with type 2 diabetes.
abstract: OBJECTIVE
  To clarify the association of serum leptin levels with progression of diabetic kidney disease in patients with type 2 diabetes (T2D).
  
  
  METHODS
  This was an observational cohort study of 668 patients with T2D. Patients were classified into three groups by sex-specific tertile of leptin levels. Outcome measurements were the rate of change in estimated glomerular filtration rate (eGFR) and progression to a more advanced stage of albuminuria.
  
  
  RESULTS
  Patients with low or high leptin levels had a steeper eGFR decline (-2.07 and -2.14 mL/min/1.73 m(2)/year) than those with midrange leptin levels (-0.82 mL/min/1.73 m(2)/year; P < 0.01), whereas patients with low leptin levels had an elevated risk of progression of albuminuria as compared with those with high leptin levels (hazard ratio 3.125 [95% CI 1.302-7.499]).
  
  
  CONCLUSIONS
  Both low and high serum leptin levels were risk factors for kidney function decline. Meanwhile, lower serum leptin levels were associated with progression of albuminuria.
authors: Division of Nephrology and Hypertension, Diabetes Center, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan.
authors: Ko
authors: K
authors: Hanai
authors: Tetsuya
authors: T
authors: Babazono
authors: Michino
authors: M
authors: Mugishima
authors: Naoshi
authors: N
authors: Yoshida
authors: Izumi
authors: I
authors: Nyumura
authors: Kiwako
authors: K
authors: Toya
authors: Ryotaro
authors: R
authors: Bouchi
authors: Nobue
authors: N
authors: Tanaka
authors: Yasuko
authors: Y
authors: Uchigata
mesh_terms: D000368:Aged; D000419:Albuminuria / Q000150:complications; D044466:Asian People; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology*; D003928:Diabetic Nephropathies / Q000097:blood / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D020738:Leptin