title: Bromine-lithium exchange: An efficient tool in the modular construction of biaryl ligands.
abstract: Regioselective bromine-lithium exchange reactions on polybrominated biaryls enable the modular synthesis of various polysubstituted biphenyls such as bis(dialkylphosphino)-, bis(diarylphosphino)- and dialkyl(diaryl)phosphinobiphenyls. All permutations of substituents at the ortho positions of the biphenyls are possible. In a similar manner, one can gain access to monophosphine analogues. So far, such a process, based on the effective discrimination between bromine atoms as a function of their chemical environment, has been observed only sporadically.
authors: Laboratoire de stéréochimie, UMR 7509, CNRS-Université de Strasbourg, ECPM, 25 rue Becquerel, F-67087 Strasbourg Cedex 02, France.
authors: Laurence
authors: L
authors: Bonnafoux
authors: Frédéric R
authors: FR
authors: Leroux
authors: Françoise
authors: F
authors: Colobert