title: Brief report: Platelet-poor plasma serotonin in autism.
abstract: Possible explanations for the well-replicated platelet hyperserotonemia of autism include an alteration in the platelet's handling of serotonin (5-hydroxyserotonin, 5-HT) or an increased exposure of the platelet to 5-HT. Measurement of platelet-poor plasma (PPP) levels of 5-HT appears to provide the best available index of in vivo exposure of the platelet to 5-HT. Mean (± SD) concentrations of PPP 5-HT observed in the autism (N = 18), hyperserotonemic subgroup (N = 5) and control (N = 24) groups were 0.86 ± 0.53, 0.87 ± 0.43 and 0.86 ± 0.36 nM, respectively. The results suggest that the hyperserotonemia of autism is not due to increased exposure of the platelet to 5-HT and make it more likely that the factor(s) contributing to the hyperserotonemia of autism have to do with the platelet's handling of 5-HT.
authors: Departments of Child Psychiatry & Laboratory Medicine, Yale University School of Medicine, 230 S Frontage Rd, New Haven, CT 06520, USA. george.anderson@yale.edu
authors: George M
authors: GM
authors: Anderson
authors: Margaret E
authors: ME
authors: Hertzig
authors: P A
authors: PA
authors: McBride
mesh_terms: D000293:Adolescent; D001792:Blood Platelets / Q000378:metabolism*; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000097:blood*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D010976:Platelet Count; D012016:Reference Values; D012701:Serotonin / Q000097:blood*; D055815:Young Adult
chemical_list: D012701:Serotonin