title: Lipofundin-induced hyperlipidemia promotes oxidative stress and atherosclerotic lesions in new zealand white rabbits.
abstract: Atherosclerosis represents a major cause of death in the world. It is known that Lipofundin 20% induces atherosclerotic lesions in rabbits, but its effects on serum lipids behaviour and redox environment have not been addressed. In this study, New Zealand rabbits were treated with 2 mL/kg of Lipofundin for 8 days. Then, redox biomarkers and serum lipids were determined spectrophotometrically. On the other hand, the development of atherosclerotic lesions was confirmed by eosin/hematoxylin staining and electron microscopy. At the end of the experiment, total cholesterol, triglycerides, cholesterol-LDL, and cholesterol-HDL levels were significantly increased. Also, a high index of biomolecules damage, a disruption of both enzymatic and nonenzymatic defenses, and a reduction of nitric oxide were observed. Our data demonstrated that Lipofundin 20% induces hyperlipidemia, which promotes an oxidative stress state. Due to the importance of these phenomena as risk factors for atherogenesis, we suggest that Lipofundin induces atherosclerosis mainly through these mechanisms.
authors: Center of Studies for Research and Biological Evaluations, Pharmacy and Food Science College, University of Havana, PO. Box 13 600, La Coronela, La Lisa, Havana 13600, Cuba.
authors: Livan
authors: L
authors: Delgado Roche
authors: Emilio
authors: E
authors: Acosta Medina
authors: Angela
authors: A
authors: Fraga Pérez
authors: María A
authors: MA
authors: Bécquer Viart
authors: Yosdel
authors: Y
authors: Soto López
authors: Viviana
authors: V
authors: Falcón Cama
authors: Ana M
authors: AM
authors: Vázquez López
authors: Gregorio
authors: G
authors: Martínez-Sánchez
authors: Eduardo
authors: E
authors: Fernández-Sánchez