title: Mobilization of Stem Cells Using G-CSF for Acute Ischemic Stroke: A Randomized Controlled, Pilot Study.
abstract: Background. There is emerging evidence to support the use of granulocyte colony-stimulating factor (G-CSF) therapy in patients with acute ischemic stroke. Aims. To explore feasibility, safety, and preliminary efficacy of G-CSF therapy in patients with acute ischemic stroke. Patients and Method. In randomized study, 10 patients with acute ischemic stroke were recruited in 1 : 1 ratio to receive 10 μg/kg G-CSF treatment subcutaneously daily for five days with conventional care or conventional treatment alone. Efficacy outcome measures were assessed at baseline, one month, and after six months of treatment included Barthel Index (BI), National Institute of Health Stroke Scale, and modified Rankin Scale. Results. One patient in G-CSF therapy arm died due to raised intracranial pressure. No severe adverse effects were seen in rest of patients receiving G-CSF therapy arm or control arm. No statistically significant difference between intervention and control was observed in any of the scores though a trend of higher improvement of BI score is seen in the intervention group. Conclusion. Although this study did not have power to examine efficacy, it provides preliminary evidence of potential safety, feasibility, and tolerability of G-CSF therapy. Further studies need to be done on a large sample to confirm the results.
authors: Department of Neurology, Room No. 704, Neurosciences Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
authors: Kameshwar
authors: K
authors: Prasad
authors: Amit
authors: A
authors: Kumar
authors: Jitendra Kumar
authors: JK
authors: Sahu
authors: M V P
authors: MV
authors: Srivastava
authors: Sujata
authors: S
authors: Mohanty
authors: Rohit
authors: R
authors: Bhatia
authors: Shailesh B
authors: SB
authors: Gaikwad
authors: Achal
authors: A
authors: Srivastava
authors: Vinay
authors: V
authors: Goyal
authors: Manjari
authors: M
authors: Tripathi
authors: Chandrashekar
authors: C
authors: Bal
authors: Nalini Kant
authors: NK
authors: Mishra