title: A chemical investigation of the Antarctic sponge Lyssodendoryx flabellata.
abstract: From the Antarctic sponge Lyssodendoryx flabellata, a new polycyclic compound, which we named flabellone, related to the oestrogenic hormone oestrone, has been elucidated by spectrometric and spectroscopic means. Along with flabellone, a glycosphingolipid (GSL) mixture featuring an unusual α-fucofuranosyl-3-β-glucopyranoside unit structurally identical to the previously reported terpioside has been isolated and identified. The mixture of GSL homologues exhibited inhibitory effects in mixed lymphocyte reactions on human cells.
authors: Istituto di Chimica Biomolecolare-CNR, via Campi Flegrei 34, Pozzuoli, Naples, Italy. acutignano@icb.cnr.it
authors: A
authors: A
authors: Cutignano
authors: R
authors: R
authors: De Palma
authors: A
authors: A
authors: Fontana
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D006028:Glycosphingolipids / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D007155:Immunologic Factors / Q000737:chemistry* / Q000494:pharmacology*; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*
chemical_list: D006028:Glycosphingolipids; D007155:Immunologic Factors