title: Cervical adenoid basal carcinoma associated with invasive squamous cell carcinoma: a report of rare co-existence and review of literature.
abstract: Cervical adenoid basal carcinoma (ABC) rarely can harbor associated malignancies like adenoid cystic carcinoma or squamous cell carcinoma (SCC), which express markedly different prognosis from a pure ABC, making an appropriate biopsy essential to provide a clear diagnosis and therapeutic plan. We report a 64-year-old asymptomatic lady with an abnormal cervical cytology, who underwent a conization to reveal an ABC with overlying microinvasive SCC. Doubtful resection margins led us to perform radical hysterectomy with lymph node dissection. Subsequent pathological examination showed a true invasive SCC co-existing with ABC, with invasion of the parametrium. Unlike the indolent course of many pure ABC patients, the prognosis of 11 previously reported co-existing invasive SCC with ABC patients appears to depend on the SCC component. Our case reiterates the importance of adequate biopsy with careful interpretation to cover the possibility of a co-existent malignancy. Besides, it presents an argument in favor of radical surgery for the primary treatment of suspicious associated malignancy, and supports adjuvant treatment according to the unfavorable extent of the co-existent invasive carcinoma.
authors: Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
authors: Boonlert
authors: B
authors: Viriyapak
authors: Sung Taek
authors: ST
authors: Park
authors: Ah Won
authors: AW
authors: Lee
authors: Jong Sup
authors: JS
authors: Park
authors: Chung Won
authors: CW
authors: Lee
authors: Min Jong
authors: MJ
authors: Song
authors: Soo Young
authors: SY
authors: Hur
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D003528:Carcinoma, Adenoid Cystic / Q000150:complications / Q000473:pathology* / Q000628:therapy; D002280:Basal Cell Carcinoma / Q000150:complications / Q000473:pathology* / Q000628:therapy; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D019092:Conization; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008197:Lymph Node Excision; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000628:therapy; D011379:Prognosis; D012196:Review Literature as Topic; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000473:pathology* / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents