title: Comparison of MRI, F-18 FDG, and 11C-choline PET/CT for their potentials in differentiating brain tumor recurrence from brain tumor necrosis following radiotherapy.
abstract: OBJECTIVE
  To compare potentials of magnetic resonance imaging (MRI), F-18 FDG, and 11C-Choline PET/CT in differentiating brain tumor recurrence from necrosis after radiotherapy.
  
  
  METHODS
  Fifty-five patients with suspected brain tumor recurrence or necrosis after radiotherapy underwent MRI, F-18 FDG, and 11C-choline PET/CT examinations, and all the patients were followed up for at least 11 months. Lesion diagnoses based on medical imaging were compared with pathology or follow-up outcomes.
  
  
  RESULTS
  The sensitivities of MRI, F-18 FDG PET/CT, and 11C-Choline PET/CT in lesion diagnosis were 87.2%, 76.9%, and 92.3%, respectively, and their specificities were 81.3%, 62.5%, and 87.5%, respectively.
  
  
  CONCLUSIONS
  The results suggest that 11C-Choline PET/CT with higher sensitivity and specificity may be better in distinguishing recurrent brain tumor from radionecrosis compared with F-18 FDG PET/CT and MRI.
authors: PET Center, Huashan Hospital of Fudan University, Shanghai, China.
authors: Haibo
authors: H
authors: Tan
authors: Limin
authors: L
authors: Chen
authors: Yihui
authors: Y
authors: Guan
authors: Xiangtong
authors: X
authors: Lin
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy; D002794:Choline; D003937:Diagnosis, Differential; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D009336:Necrosis / Q000000981:diagnostic imaging / Q000209:etiology; D049268:Positron-Emission Tomography; D011832:Radiation Injuries / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D019788:Fluorodeoxyglucose F18; D002794:Choline