title: Quantitative relationship between the extent and morphology of coronary atherosclerotic plaque and downstream myocardial perfusion.
abstract: OBJECTIVE
  The purpose of this study was to quantify the effects of coronary atherosclerosis morphology and extent on myocardial flow reserve (MFR).
  
  
  BACKGROUND
  Although the relationship between coronary stenosis and myocardial perfusion is well established, little is known about the contribution of other anatomic descriptors of atherosclerosis burden to this relationship.
  
  
  METHODS
  We evaluated the relationship between atherosclerosis plaque burden, morphology, and composition and regional MFR (MFR(regional)) in 73 consecutive patients undergoing Rubidium-82 positron emission tomography and coronary computed tomography angiography for the evaluation of known or suspected coronary artery disease.
  
  
  RESULTS
  Atherosclerosis was seen in 51 of 73 patients and in 107 of 209 assessable coronary arteries. On a per-vessel basis, the percentage diameter stenosis (p = 0.02) or summed stenosis score (p = 0.002), integrating stenoses in series, was the best predictor of MFR(regional). Importantly, MFR(regional) varied widely within each coronary stenosis category, even in vessels with nonobstructive plaques (n = 169), 38% of which had abnormal MFR(regional) (<2.0). Total plaque length, composition, and remodeling index were not associated with lower MFR. On a per-patient basis, the modified Duke CAD (coronary artery disease) index (p = 0.04) and the number of segments with mixed plaque (p = 0.01) were the best predictors of low MFR(global).
  
  
  CONCLUSIONS
  Computed tomography angiography descriptors of atherosclerosis had only a modest effect on downstream MFR. On a per-patient basis, the extent and severity of atherosclerosis as assessed by the modified Duke CAD index and the number of coronary segments with mixed plaque were associated with decreased MFR.
authors: Noninvasive Cardiovascular Imaging Program, Department of Medicine (Cardiology), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors: Masanao
authors: M
authors: Naya
authors: Venkatesh L
authors: VL
authors: Murthy
authors: Ron
authors: R
authors: Blankstein
authors: Arkadiusz
authors: A
authors: Sitek
authors: Jon
authors: J
authors: Hainer
authors: Courtney
authors: C
authors: Foster
authors: Mariya
authors: M
authors: Gaber
authors: Jolene M
authors: JM
authors: Fantony
authors: Sharmila
authors: S
authors: Dorbala
authors: Marcelo F
authors: MF
authors: Di Carli
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003326:Coronary Circulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging* / Q000503:physiopathology; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed