title: Personalized vascular medicine: individualizing drug therapy.
abstract: Personalized medicine refers to the application of an individual's biological fingerprint - the comprehensive dataset of unique biological information - to optimize medical care. While the principle itself is straightforward, its implementation remains challenging. Advances in pharmacogenomics as well as functional assays of vascular biology now permit improved characterization of an individual's response to medical therapy for vascular disease. This review describes novel strategies designed to permit tailoring of four major pharmacotherapeutic drug classes within vascular medicine: antiplatelet therapy, antihypertensive therapy, lipid-lowering therapy, and antithrombotic therapy. Translation to routine clinical practice awaits the results of ongoing randomized clinical trials comparing personalized approaches with standard of care management.
authors: Division of Cardiovascular Medicine, University of Pennsylvania, Philadelphia, USA. Emil.deGoma@uphs.upenn.edu
authors: Emil M
authors: EM
authors: Degoma
authors: Giovanni
authors: G
authors: Rivera
authors: Scott M
authors: SM
authors: Lilly
authors: M Haris U
authors: MH
authors: Usman
authors: Emile R
authors: ER
authors: Mohler
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000235:genetics; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D060005:Genotyping Techniques; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D057285:Precision Medicine / Q000379:methods*
chemical_list: D000959:Antihypertensive Agents; D005343:Fibrinolytic Agents; D000960:Hypolipidemic Agents; D010975:Platelet Aggregation Inhibitors