title: [Expression of CCR1 in the orbital fibroblasts with thyroid associated ophthalmopathy].
abstract: OBJECTIVE
  To investigate the expression of chemokine receptor (CCR1) in the orbital fibroblasts (OFs) with thyroid associated ophthalmopathy (TAO) and to explore the pathogenesis of TAO.
  
  
  METHODS
  By immunohistochemistry, the expression of CCR1 was studied in 25 cases of TAO patients and 10 normal control subjects and the correlation between CCR1 and GAS was analysed.
  
  
  RESULTS
  The expression of CCR1 in the OFs with TAO was positive, but it was negative or weak positive in normal control subjects. The difference between them was significant (P < 0.05). And the expression of CCR1 in the OFs with TAO had no significant correlation with GAS (r = 0. 048, P > 0.05).
  
  
  CONCLUSIONS
  The expression of chemokine receptor CCR1 is higher on OFs of TAO patients than that of normal subjects. CCR1 maybe play a role in pathogenesis of TAO.
authors: Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, China.
authors: Chun-Ling
authors: CL
authors: Liu
authors: Xue-Jin
authors: XJ
authors: Zhang
authors: Bo
authors: B
authors: Guo
authors: Jun-Feng
authors: JF
authors: Yang
authors: Qing-Li
authors: QL
authors: Luo
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005347:Fibroblasts / Q000378:metabolism*; D049970:Graves Ophthalmopathy / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009915:Orbit / Q000378:metabolism / Q000473:pathology*; D054389:Receptors, CCR1 / Q000235:genetics / Q000378:metabolism*; D055815:Young Adult
chemical_list: C515300:CCR1 protein, human; D054389:Receptors, CCR1