title: Modulation of the cytokine response in human monocytes by mycobacterium leprae phenolic glycolipid-1.
abstract: Leprosy is a chronic but treatable infectious disease caused by the intracellular pathogen Mycobacterium leprae. M. leprae cell wall is characterized by a unique phenolic glycolipid-1 (PGL-1) reported to have several immune functions. We have examined the role of PGL-1 in the modulation of monocyte cytokine/chemokine production in naive human monocytes. PGL-1 in its purified form or expressed in a recombinant Mycobacterium bovis Bacillus Colmette-Guérin (BCG) background (rBCG-PGL-1) was tested. We found that PGL-1 selectively modulated the induction of specific monocyte cytokines and chemokines and, when used as prestimulus, exerted priming and/or inhibitory effects on the induction of selected cytokines/chemokines in response to a second stimulus. Taken together, the results of this study support a modulatory role for PGL-1 in the innate immune response to M. leprae. Thus, PGL-1 may play an important role in the development of the anergic clinical forms of disease and in tissue damage seen in lepromatous patients and during the reactional states of leprosy.
authors: Laboratory of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute at the International Center for Public Health, Newark, New Jersey 07103-3535, USA.
authors: Claudia
authors: C
authors: Manca
authors: Blas
authors: B
authors: Peixoto
authors: Wladimir
authors: W
authors: Malaga
authors: Christophe
authors: C
authors: Guilhot
authors: Gilla
authors: G
authors: Kaplan
mesh_terms: D000942:Antigens, Bacterial / Q000276:immunology*; D018925:Chemokines / Q000096:biosynthesis / Q000276:immunology; D016207:Cytokines / Q000096:biosynthesis*; D006017:Glycolipids / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D009000:Monocytes / Q000276:immunology* / Q000378:metabolism; D009163:Mycobacterium bovis / Q000276:immunology; D009166:Mycobacterium leprae / Q000276:immunology
chemical_list: D000942:Antigens, Bacterial; D018925:Chemokines; D016207:Cytokines; D006017:Glycolipids; C045169:phenolic glycolipid I, Mycobacterium leprae