title: [Suppression of colon cancer in murine model by recombinant human endostatin adenovirus and cisplatin].
abstract: OBJECTIVE
  To investigate the efficacy, side effect and anti-tumor mechanism of recombinant human endostatin adenovirus (Ad-hE) and cisplatin on murine colon cancer.
  
  
  METHODS
  Mice with CT26 colon cancer were randomly divided into 5 groups, being given Ad-hE via tail vein, cisplatin (Cis) intraperitoneally, Ad-hE plus cisplatin (Ad-hE+Cis), empty adenovirus (Ad-N), and saline (NS), respectively. The therapeutic effect and side effect of the treatments and the angiogenesis and apoptosis of tumor cells were observed.
  
  
  RESULTS
  Ad-hE + Cis suppressed the growth of lung metastatic tumor and prolonged survival time of the murine CT26 colon cancer model. The anti-tumor activity was associated with decreased microvessel density and increased apoptosis of tumor cells.
  
  
  CONCLUSIONS
  Recombinant human endostatin adenovirus enhances the anti-tumor activity of cisplatin without increasing toxicity.
authors: State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China.
authors: Lian
authors: L
authors: Wang
authors: Li
authors: L
authors: Yang
authors: Yang
authors: Y
authors: Wu
authors: Xin-Rong
authors: XR
authors: Jing
authors: Li
authors: L
authors: Wang
authors: Huan-Yi
authors: HY
authors: Liu
authors: Qiu
authors: Q
authors: Li
mesh_terms: D000256:Adenoviridae / Q000235:genetics / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002945:Cisplatin / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000473:pathology*; D003131:Combined Modality Therapy; D043169:Endostatins / Q000096:biosynthesis* / Q000235:genetics; D015316:Genetic Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary* / Q000628:therapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000235:genetics / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D043169:Endostatins; D011994:Recombinant Proteins; D002945:Cisplatin