title: Pulmonary zygomycosis with Cunninghamella bertholletiae in a killer whale (Orcinus orca).
abstract: An adult female killer whale (Orcinus orca) was transported to the Port of Nagoya public aquarium in June 2010. While the animal was being maintained in the aquarium there was a gradual decrease in body weight. On October 1st, 2010 the whale exhibited signs of gastrointestinal disease and died on January 14th, 2011. At necropsy examination the gastric compartments were filled with a large number of variably-sized rocks (total weight 81.4 kg) and there was marked ulceration in the third compartment. There were multifocal tubercle-like nodules within the lungs and on sectioning there were numerous abscesses and pulmonary cavities. Microscopically, there was severe suppurative pneumonia associated with fungal hyphae that were infrequently septate and often branched. Numerous bacterial colonies were also present. The hyphae demonstrated immunohistochemical cross-reactivity with Rhizomucor spp. and Cunninghamella bertholletiae was cultured. Bacteriological culture revealed the presence of Proteus mirabilis, Pseudomonas aeruginosa and Pseudomonas oryzihabitans. This case represents the first documentation of zygomycosis associated with C. bertholletiae in a marine mammal.
authors: Department of Veterinary Pathology, Faculty of Applied Biological Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
authors: W
authors: W
authors: Abdo
authors: Y
authors: Y
authors: Kakizoe
authors: M
authors: M
authors: Ryono
authors: S R
authors: SR
authors: Dover
authors: H
authors: H
authors: Fukushi
authors: H
authors: H
authors: Okuda
authors: R
authors: R
authors: Kano
authors: T
authors: T
authors: Shibahara
authors: E
authors: E
authors: Okada
authors: H
authors: H
authors: Sakai
authors: T
authors: T
authors: Yanai
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D020093:Cunninghamella / Q000302:isolation & purification; D005260:Female; D006403:Hematologic Tests / Q000662:veterinary*; D008172:Lung Diseases, Fungal / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D009091:Mucormycosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D050685:Whale, Killer
chemical_list: D000935:Antifungal Agents