title: Novel 4,5-dihydro-thiazinogeldanamycin in a gdmP mutant strain of Streptomyces hygroscopicus 17997.
abstract: Novel geldanamycin derivative, 4,5-dihydro-thiazinogeldanamycin (3), was characterized from the gdmP mutant in Streptomyces hygroscopicus 17997, besides expected 4,5-dihydro-geldanamycin (2). The presence of this compound would suggest an unknown post-PKS modification in geldanamycin biosynthesis. Compound 3 exhibited moderate anti-HSV-1-virus activity and higher water solubility than geldanamycin (1). Cysteine served as a precursor to synthesize 3, whose formation required obligatory enzymatic assistance.
authors: Northeast Agricultural University, Harbin, China.
authors: Ling
authors: L
authors: Lin
authors: SiYang
authors: S
authors: Ni
authors: LinZhuan
authors: L
authors: Wu
authors: YiGuang
authors: Y
authors: Wang
authors: YuCheng
authors: Y
authors: Wang
authors: PeiZhen
authors: P
authors: Tao
authors: WeiQing
authors: W
authors: He
authors: XiangJing
authors: X
authors: Wang
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism*; D016227:Benzoquinones / Q000737:chemistry* / Q000378:metabolism*; D047029:Lactams, Macrocyclic / Q000737:chemistry* / Q000378:metabolism*; D009154:Mutation; D015202:Protein Engineering; D013302:Streptomyces / Q000235:genetics* / Q000378:metabolism*; D013843:Thiazines / Q000737:chemistry* / Q000378:metabolism*
chemical_list: C569935:4,5-dihydrothiazinogeldanamycin; D001426:Bacterial Proteins; D016227:Benzoquinones; D047029:Lactams, Macrocyclic; D013843:Thiazines; C001277:geldanamycin