title: Misfolded proteins driven to destruction by Hul5.
abstract: Misfolded proteins are potentially toxic and are therefore subjected to highly selective degradation by the ubiquitin-proteasome system. The identification of the Hul5 ubiquitin ligase as a major mediator of such 'quality-control' ubiquitylation following heat shock raises new questions about the design of these pathways.
authors: Daniel
authors: D
authors: Finley
mesh_terms: D003600:Cytosol / Q000201:enzymology*; D011499:Protein Processing, Post-Translational; D012441:Saccharomyces cerevisiae / Q000201:enzymology*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
chemical_list: D029701:Saccharomyces cerevisiae Proteins; C468547:HUL5 protein, S cerevisiae; D044767:Ubiquitin-Protein Ligases