title: Evaluation of striatal oxidative stress in patients with Parkinson's disease using [62Cu]ATSM PET.
abstract: BACKGROUND
  To clarify the role of oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson's disease (PD) in living patients, positron emission tomography (PET) with [(62)Cu]diacetyl-bis(N(4)-methylthiosemicarbazone) ([(62)Cu]ATSM) was applied to functional imaging of oxidative stress mainly due to mitochondrial dysfunction in the striata of patients with PD.
  
  
  METHODS
  Fifteen PD patients who presented with lateral dominant symptoms at onset and six healthy controls underwent [(62)Cu]ATSM PET. Dynamic PET data acquisition was performed, and standardized uptake values (SUVs) were obtained from the delayed phase of dynamic data by means of region of interest analysis. The striatum-to-cerebellum SUV ratio (S/C ratio) was calculated from the SUV in all subjects of the striatum and the cerebellar cortex.
  
  
  RESULTS
  The mean S/C ratio of the bilateral striata of the patients (1.15±0.10) was significantly increased compared with that of the controls (1.08±0.02) (P<.05). In the patients, the S/C ratio of the bilateral striata showed a positive correlation with the Unified Parkinson's Disease Rating Scale (UPDRS) rating (r=0.52, P<.05), and the S/C ratio of the striatum contralateral to the initially affected body side showed a strong positive correlation with the UPDRS rating (r=0.62, P<.05).
  
  
  CONCLUSIONS
  [(62)Cu]ATSM PET imaging demonstrated that striatal oxidative stress was enhanced in PD patients compared with the controls and increased with the progression of disease severity, particularly in the contralateral striatum. These findings indicated that oxidative stress associates with striatal neurodegeneration in PD.
authors: Second Department of Internal Medicine (Neurology), Faculty of Medical Sciences, University of Fukui, Eiheiji-cho, Fukui 910-1193, Japan.
authors: Masamichi
authors: M
authors: Ikawa
authors: Hidehiko
authors: H
authors: Okazawa
authors: Takashi
authors: T
authors: Kudo
authors: Masaru
authors: M
authors: Kuriyama
authors: Yasuhisa
authors: Y
authors: Fujibayashi
authors: Makoto
authors: M
authors: Yoneda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D056831:Coordination Complexes; D003301:Copper Radioisotopes; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000378:metabolism / Q000473:pathology; D017072:Neostriatum / Q000000981:diagnostic imaging / Q000378:metabolism*; D009942:Organometallic Compounds; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology; D049268:Positron-Emission Tomography; D013882:Thiosemicarbazones; D013997:Time Factors
chemical_list: D056831:Coordination Complexes; D003301:Copper Radioisotopes; D009942:Organometallic Compounds; D013882:Thiosemicarbazones; C089548:copper (II) diacetyl-di(N(4)-methylthiosemicarbazone)