title: Enhancement of placental antioxidative function and P-gp expression by sodium ferulate mediated its protective effect on rat IUGR induced by prenatal tobacco/alcohol exposure.
abstract: This study was aimed to explore the therapeutic effect of sodium ferulate (SF) on rats with intrauterine growth retardation (IUGR), and then to clarify the corresponding mechanism. Pregnant rats were divided into normal group, tobacco/alcohol exposure group, and tobacco/alcohol+SF groups. Fetal developmental indices, placental weight, histological alteration, oxidative and antioxidative-function (e.g. MDA, SOD, CAT) and Mdr1 levels were assayed. Results showed exposure to tobacco/alcohol resulted in reduced fetal developmental indices and placental histological alteration, as well as the increased MDA content, decreased SOD and CAT activities and decreased Mdr1a level. After SF treatment, fetal developmental indices, and placental weight, histological alteration, oxidative and antioxidative-function and mdr1a levels were reversed. Our study indicated SF may be effective in reversing IUGR production, and its underlying mechanism may be due to enhanced placental antioxidative function and P-gp expression, which may be related to IUGR formation by tobacco/alcohol exposure.
authors: Department of Pharmacology of Basic Medical College, Wuhan University, Wuhan 430071, China.
authors: Yan
authors: Y
authors: Li
authors: You-E
authors: YE
authors: Yan
authors: Hui
authors: H
authors: Wang
mesh_terms: D000818:Animals; D005260:Female; D008297:Male; D011247:Pregnancy; D051381:Rats; D000975:Antioxidants / Q000378:metabolism; D018435:ATP Binding Cassette Transporter, Subfamily B / Q000378:metabolism; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D000097202:ATP-Binding Cassette Sub-Family B Member 4; D002374:Catalase / Q000378:metabolism; D003373:Coumaric Acids / Q000494:pharmacology; D000431:Ethanol / Q000009:adverse effects; D047109:Fetal Development / Q000187:drug effects; D005317:Fetal Growth Retardation / Q000188:drug therapy / Q000209:etiology; D009929:Organ Size / Q000187:drug effects; D010920:Placenta / Q000187:drug effects; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism; D015430:Weight Gain / Q000187:drug effects; D011297:Prenatal Exposure Delayed Effects; D014028:Tobacco Smoke Pollution
chemical_list: D000975:Antioxidants; D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000097202:ATP-Binding Cassette Sub-Family B Member 4; D002374:Catalase; D003373:Coumaric Acids; D000431:Ethanol; C004999:ferulic acid; C095122:multidrug resistance protein 3; D013482:Superoxide Dismutase; D014028:Tobacco Smoke Pollution