title: Complex pleural empyema can be safely treated with vacuum-assisted closure.
abstract: OBJECTIVE
  For patients with postoperative pleural empyema, open window thoracostomy (OWT) is often necessary to prevent sepsis. Vacuum-assisted closure (VAC) is a well-known therapeutic option in wound treatment. The efficacy and safety of intrathoracal VAC therapy, especially in patients with pleural empyema with bronchial stump insufficiency or remain lung, has not yet been investigated.
  
  
  METHODS
  Between October 2009 and July 2010, eight consecutive patients (mean age of 66.1 years) with multimorbidity received an OWT with VAC for the treatment of postoperative or recurrent pleural empyema. Two of them had a bronchial stump insufficiency (BPF).
  
  
  RESULTS
  VAC therapy ensured local control of the empyema and control of sepsis. The continuous suction up to 125 mm Hg cleaned the wound and thoracic cavity and supported the rapid healing. Additionally, installation of a stable vacuum was possible in the two patients with BPF. The smaller bronchus stump fistula closed spontaneously due to the VAC therapy, but the larger remained open. The direct contact of the VAC sponge did not create any air leak or bleeding from the lung or the mediastinal structures. The VAC therapy allowed a better re-expansion of remaining lung. One patient died in the late postoperative period (day 47 p.o.) of multiorgan failure. In three cases, VAC therapy was continued in an outpatient service, and in four patients, the OWT was treated with conventional wound care. After a mean time of three months, the chest wall was closed in five of seven cases. However, two patients rejected the closure of the OWT. After a follow-up at 7.7 months, neither recurrent pleural empyema nor BPF was observed.
  
  
  CONCLUSIONS
  VAC therapy was effective and safe in the treatment of complicated pleural empyema. The presence of smaller bronchial stump fistula and of residual lung tissue are not a contraindication for VAC therapy.
authors: Department of Thoracic Surgery, Hospital Barmherzige Brüder Regensburg, Prüfeningerstrasse 86, 93049 Regensburg, Germany. zsolt.sziklavari@barmherzige-regensburg.de
authors: Zsolt
authors: Z
authors: Sziklavari
authors: Christian
authors: C
authors: Grosser
authors: Reiner
authors: R
authors: Neu
authors: Rudolf
authors: R
authors: Schemm
authors: Ariane
authors: A
authors: Kortner
authors: Tamas
authors: T
authors: Szöke
authors: Hans-Stefan
authors: HS
authors: Hofmann
mesh_terms: D000368:Aged; D015897:Comorbidity; D016724:Empyema, Pleural / Q000401:mortality / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D054843:Negative-Pressure Wound Therapy; D012008:Recurrence; D012189:Retrospective Studies; D016896:Treatment Outcome