title: Live birth after allografting of ovarian cortex between monozygotic twins with Turner syndrome (45,XO/46,XX mosaicism) and discordant ovarian function.
abstract: OBJECTIVE
  To report the restoration of ovarian function in a woman with Turner syndrome by allografting ovarian cortex from her monozygotic twin.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Gynecology research unit in a university hospital.
  
  
  METHODS
  A 37-year-old woman with Turner syndrome who had suffered premature ovarian failure (POF) at the age of 15.
  
  
  METHODS
  In this woman, we performed ovarian cortex transplantation. The donor was her monozygotic twin who had not experienced POF and who had had two normal deliveries.
  
  
  METHODS
  Restoration of ovarian activity and pregnancy.
  
  
  RESULTS
  Restoration of ovarian function was achieved 3 months after transplantation. After 7 months of regular cycles, spontaneous pregnancy occurred. The patient delivered a healthy baby girl weighing 2,850 g at 38 weeks of gestation.
  
  
  CONCLUSIONS
  Girls with Turner syndrome suffer accelerated loss of ovarian follicles and only 2%-5% experience spontaneous menses with the potential to achieve pregnancy without medical intervention. This manuscript reports the first live birth after allografting between monozygotic twins with 45,XO/46,XX mosaicism and discordant growth pattern and ovarian function.
authors: Université Catholique de Louvain, Cliniques Universitaires St. Luc, Department of Gynecology, Brussels, Belgium. jacques.donnez@uclouvain.be
authors: Jacques
authors: J
authors: Donnez
authors: Marie-Madeleine
authors: MM
authors: Dolmans
authors: Jean
authors: J
authors: Squifflet
authors: Guy
authors: G
authors: Kerbrat
authors: Pascale
authors: P
authors: Jadoul
mesh_terms: D000328:Adult; D033001:Directed Tissue Donation; D004200:Diseases in Twins / Q000235:genetics / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006801:Humans; D050498:Live Birth; D009030:Mosaicism; D010053:Ovary / Q000502:physiology* / Q000637:transplantation*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D014184:Transplantation, Homologous; D014424:Turner Syndrome / Q000235:genetics / Q000503:physiopathology / Q000628:therapy*; D014430:Twins, Monozygotic / Q000235:genetics