title: The possible role of TRPC6 in atopic dermatitis.
abstract: Skin barrier dysfunction is involved in the pathogenesis of atopic dermatitis (AD). The impaired barrier function is related to disturbed keratinocyte differentiation through improper Ca2+-regulated pathway in AD. Transient receptor potential canonical (subtype) 6 (TRPC6) is a Ca2+-permeable nonselective cation channel expressed in keratinocytes. TRPC6 contributes to the process of keratinocyte differentiation by regulating Ca2+ influx. Furthermore, TRPC6 alone is considered to be sufficient for nearly full physiological response of keratinocyte differentiation. Until now, the correlation between TRPC6 and AD has not been investigated. We hypothesize that dysfunction of TRPC6 may trigger the process of AD, and that restoring or enhancing the activity of TRPC6 may serve as a new modality in treating AD.
authors: Department of Dermatology, Shenyang No. 7 People's Hospital, Shenyang 110003, China.
authors: Xiao-Dong
authors: XD
authors: Sun
authors: Yang
authors: Y
authors: You
authors: Li
authors: L
authors: Zhang
authors: Song
authors: S
authors: Zheng
authors: Yuxiao
authors: Y
authors: Hong
authors: Jie
authors: J
authors: Li
authors: Xing-Hua
authors: XH
authors: Gao
mesh_terms: D002118:Calcium / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology*; D003876:Dermatitis, Atopic / Q000209:etiology*; D000078404:Epidermal Cells; D004817:Epidermis / Q000502:physiology*; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism* / Q000502:physiology; D008954:Models, Biological; D050052:TRPC Cation Channels / Q000378:metabolism*; D000074287:TRPC6 Cation Channel
chemical_list: D050052:TRPC Cation Channels; D000074287:TRPC6 Cation Channel; C117032:TRPC6 protein, human; D002118:Calcium