title: Antibacterial activity of the essential oil and main components of two Dracocephalum species from Iran.
abstract: The antibacterial activity of Dracocephalum polychaetum and D. surmandinum essential oils and two main components were investigated. Essential oils of the plants were analysed by GC and GC-MS. Twenty-three components were characterised in the essential oil of D. polychaetum. The oil was rich in oxygenated (73.1%) and hydrocarbon (25.0%) monoterpenes including perilla aldehyde (63.4 %) and limonene (22.1%) as the major constituents. From 25 identified compounds (97.8%) in the oil of D. surmandinum perilla aldehyde (54.3%) and limonene (30.1%) were the main constituents. The bioassays exhibited that all of the Gram-positive and Gram-negative bacteria tested were highly inhibited in the presence of the oils and main components investigated. The most sensitive microorganism to the oils was found to be Staphylococcus epidermidis with the lowest MIC value of 0.3 mgmL(-1). The resistant Gram-negative Pseudomonas aeruginosa was highly inhibited by the oil of D. polychaetum with MIC value of 2.4 mgmL(-1).
authors: Department of Biology, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Evin 1983963113, Tehran, Iran. a-sonboli@sbu.ac.ir
authors: Ali
authors: A
authors: Sonboli
authors: Abbas
authors: A
authors: Gholipour
authors: Morteza
authors: M
authors: Yousefzadi
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D053138:Cyclohexenes / Q000737:chemistry / Q000494:pharmacology; D007492:Iran; D019686:Lamiaceae / Q000737:chemistry*; D000077222:Limonene; D008826:Microbial Sensitivity Tests; D039821:Monoterpenes / Q000737:chemistry / Q000494:pharmacology; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology*; D013212:Staphylococcus epidermidis / Q000187:drug effects; D013729:Terpenes / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D053138:Cyclohexenes; D039821:Monoterpenes; D009822:Oils, Volatile; D013729:Terpenes; C033342:perillaldehyde; D000077222:Limonene