title: Effects of atorvastatin on pathological changes in brain tissue and plasma MMP-9 in rats with intracerebral hemorrhage.
abstract: To explore the effects of atorvastatin on hydrocephalus, neurocyte apoptosis, and the level of plasma matrix metalloproteinase-9 (MMP-9) after intracerebral hemorrhage (ICH) in rats. A rat model of ICH was established by intracerebral injection of collagenase. The brain water content was determined by the wet/dry weight ratio, ultrastructural changes in brain tissue were observed by electron microscopy, and the level of plasma MMP-9 was quantified by ELISA. Atorvastatin showed significant effects in reducing the brain water content, blocking neuron apoptosis, and decreasing plasma MMP-9 in rats with ICH. There was a positive linear correlation between plasma MMP-9 and the brain water content. Atorvastatin can significantly relieve brain edema, decrease the brain injury caused by MMP-9 and protect neurons in rats with ICH.
authors: Department of Cardiovasology, Affiliated Hospital, Binzhou Medical College, Binzhou, China.
authors: Jing-Jing
authors: JJ
authors: Cui
authors: Dong
authors: D
authors: Wang
authors: Fei
authors: F
authors: Gao
authors: Yue-Rong
authors: YR
authors: Li
mesh_terms: D000818:Animals; D000069059:Atorvastatin; D001921:Brain / Q000187:drug effects* / Q000473:pathology*; D001929:Brain Edema / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000188:drug therapy / Q000378:metabolism*; D004195:Disease Models, Animal; D006538:Heptanoic Acids / Q000494:pharmacology* / Q000627:therapeutic use; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D011758:Pyrroles / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D014867:Water / Q000378:metabolism
chemical_list: D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D018696:Neuroprotective Agents; D011758:Pyrroles; D014867:Water; D000069059:Atorvastatin; D020780:Matrix Metalloproteinase 9