title: Gene expression profiling of high altitude polycythemia in Han Chinese             migrating to the Qinghai-Tibetan plateau.
abstract: Chronic mountain sickness (CMS) is a condition in which the hematocrit is increased above the normal level in residents at high altitude. High altitude polycythemia (HAPC) is the most characteristic sign of CMS. However, the pathogenesis of HAPC is poorly understood. The present study aimed to investigate the gene expression profile of HAPC in Han Chinese migrating to the Qinghai-Tibetan Plateau and to identify the pathogenetic mechanisms. A total of 9 differentially expressed genes were identified in HAPC patients using microarrays: 5 were up-regulated and 4 were down-regulated. Functional analysis of the array data revealed that cell division cycle 42 (CDC42) and the human immune response may be key features underlying the mechanism and development of HAPC.
authors: Department of Pathophysiology and High Altitude Physiology, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, PR China.
authors: Chunhua
authors: C
authors: Jiang
authors: Fuyu
authors: F
authors: Liu
authors: Yongjun
authors: Y
authors: Luo
authors: Peng
authors: P
authors: Li
authors: Jian
authors: J
authors: Chen
authors: Gang
authors: G
authors: Xu
authors: Yujie
authors: Y
authors: Wang
authors: Xiaoxu
authors: X
authors: Li
authors: Jian
authors: J
authors: Huang
authors: Yuqi
authors: Y
authors: Gao
mesh_terms: D000328:Adult; D000531:Altitude; D000532:Altitude Sickness / Q000097:blood / Q000235:genetics; D002681:China; D004641:Emigration and Immigration; D004921:Erythropoietin / Q000097:blood; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006023:Glycoproteins / Q000097:blood; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008245:Lysophospholipase / Q000097:blood; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D011086:Polycythemia / Q000097:blood / Q000235:genetics*; D017382:Reactive Oxygen Species / Q000097:blood; D018609:Tibet; D055815:Young Adult; D020764:cdc42 GTP-Binding Protein / Q000378:metabolism
chemical_list: D006023:Glycoproteins; D006454:Hemoglobins; D017382:Reactive Oxygen Species; D004921:Erythropoietin; D008245:Lysophospholipase; C011711:lysolecithin acylhydrolase; D020764:cdc42 GTP-Binding Protein