title: Best practice for peripheral blood progenitor cell mobilization and collection in adults and children: results of a Società Italiana Di Emaferesi e Manipolazione Cellulare (SIDEM) and Gruppo Italiano Trapianto Midollo Osseo (GITMO) consensus process.
abstract: BACKGROUND
  A large heterogeneity in current mobilization and collection practices is perceived. Moreover, recent evidence introduced novel issues into some specific topics. Optimization of the clinical practice, through the adoption of clinical practice guidelines, previously proved to reduce health care resource use.
  
  
  METHODS
  Two Italian scientific societies, Società Italiana Di Emaferesi e Manipolazione Cellulare (SIDEM) and Gruppo Italiano Trapianto Midollo Osseo (GITMO), perceived the need of hematologists and transfusionists to share a common paradigm in the setting of hematopoietic stem cell transplantation (SCT). The aim of the current position paper is to provide common definitions and criteria for mobilization and collection of peripheral blood stem cells both in autologous and in the allogeneic setting. Current international and national standards (i.e., International Society of Hematotherapy and Graft Engineering) and recommendations (i.e., European Group for Blood and Marrow Transplantation) were harmonized with the Panel recommendations.
  
  
  RESULTS
  The Expert Panel consisted of nine members (five transfusionists and four hematologists with both clinical and scientific experience of SCT in both pediatric and adult setting) and one methodologist and first convened on April 19, 2010: they in turn agreed on the questions to be answered by the project. Available literature was reviewed by one expert and the methodologist and presented to the other members. Statements were then formulated. SIDEM and GITMO planned an informal meeting of the Panel every 2 years to discuss relevant updates and possible changes to the recommendations.
  
  
  CONCLUSIONS
  The efforts of the expert panel members allowed to set up and share a common approach to the mobilization, enumeration, and collection issues in the field of both autologous and allogeneic peripheral blood SCT.
authors: Servizio Trasfusionale, UOS Aferesi e Nuove Tecnologie Trasfusionali, Azienda Ospedaliera San Gerardo, Via Pergolesi 33 20900 Monza (MB) Italy. p.perseghin@hsgerardo.org
authors: Luca
authors: L
authors: Pierelli
authors: Paolo
authors: P
authors: Perseghin
authors: Monia
authors: M
authors: Marchetti
authors: Patrizia
authors: P
authors: Accorsi
authors: Renato
authors: R
authors: Fanin
authors: Chiara
authors: C
authors: Messina
authors: Attilio
authors: A
authors: Olivieri
authors: Marco
authors: M
authors: Risso
authors: Laura
authors: L
authors: Salvaneschi
authors: Alberto
authors: A
authors: Bosi
mesh_terms: D000328:Adult; D001781:Blood Component Removal; D001782:Blood Donors; D002452:Cell Count; D002469:Cell Separation / Q000379:methods*; D002648:Child; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D006801:Humans; D036102:Peripheral Blood Stem Cell Transplantation; D014182:Transplantation, Autologous
chemical_list: D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor