title: Chronic inflammation and immunologic-based constraints in malignant disease.
abstract: Acute inflammatory reactions benefit the host by supporting the effective clearance of pathogens and fostering wound healing, in addition to other self-preservative processes. However, when the inflammatory program is not resolved, becoming chronic in nature, it creates an environment conducive to cancer development and progression. Therefore, minimizing exposure to risk factors that contribute to chronic inflammation and reconditioning the host towards a state of (at least locoregional) acute inflammation would meaningfully impact cancer incidence and its treatment, respectively. Regarding cancer therapy, combinational treatments that both disrupt chronic inflammation and install specific adaptive type I immunity are predicted to enhance quality of life and extend the overall survival of patients.
authors: Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
authors: Devin B
authors: DB
authors: Lowe
authors: Walter J
authors: WJ
authors: Storkus
mesh_terms: D000208:Acute Disease; D056704:Adaptive Immunity; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000276:immunology; D002908:Chronic Disease; D018450:Disease Progression; D006801:Humans; D007167:Immunotherapy; D007249:Inflammation; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D012307:Risk Factors; D018417:Th1 Cells / Q000276:immunology