title: Degradation of target oligosaccharides by anthraquinone-lectin hybrids with light switching.
abstract: Anthraquinone-lectin hybrids were effectively synthesized using water-soluble anthraquinone derivative 11 with concanavalin A (ConA) and hygrophorus russula lectin (HRL) to give anthraquinone-ConA (16) and anthraquinone-HRL (17) hybrids, respectively. These anthraquinone-lectin hybrids effectively and selectively degraded oligosaccharides containing a mannose residue as a non-reducing terminal sugar, which has affinity for ConA and HRL, under photo-irradiation with long-wavelength UV light without additives and under neutral conditions. In addition, anthraquinone-HRL (17) selectively photo-degraded only Man(α1,6)Man, which has a high affinity for HRL, among several mannosides by recognition of both the type and glycosidic linkage profile of the sugar in an oligosaccharide.
authors: Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Kohoku-ku, Yokohama, Japan.
authors: Yukari
authors: Y
authors: Imai
authors: Shingo
authors: S
authors: Hirono
authors: Haruka
authors: H
authors: Matsuba
authors: Tomohiro
authors: T
authors: Suzuki
authors: Yuka
authors: Y
authors: Kobayashi
authors: Hirokazu
authors: H
authors: Kawagishi
authors: Daisuke
authors: D
authors: Takahashi
authors: Kazunobu
authors: K
authors: Toshima
mesh_terms: D000880:Anthraquinones / Q000737:chemistry*; D037102:Lectins / Q000737:chemistry*; D015394:Molecular Structure; D009844:Oligosaccharides / Q000737:chemistry*; D012995:Solubility; D014466:Ultraviolet Rays; D014867:Water / Q000737:chemistry
chemical_list: D000880:Anthraquinones; D037102:Lectins; D009844:Oligosaccharides; D014867:Water