title: Dendritic carrier based on PEG: design and degradation of acid-sensitive dendrimer-like poly(ethylene oxide)s.
abstract: Degradable dendrimer-like PEOs were designed using an original ABC-type branching agent featuring a cleavable ketal group, following an iterative divergent approach based on the anionic ring opening polymerization (AROP) of ethylene oxide and arborization of PEO chain ends. A seventh generation dendrimer-like PEO carrying 192 peripheral hydroxyls and exhibiting a molar mass of 446 kg · mol(-1) was obtained in this way. The chemical degradation of these dendritic scaffolds was next successfully accomplished under acidic conditions, forming linear PEO chains of low molar mass (≈2 kg · mol(-1)), as monitored by (1)H NMR, SEC, and MALDI-TOF mass spectrometry as well as by AFM.
authors: Laboratoire de Chimie des Polymères Organiques, 16 Av. Pey Berland, F-33607 Pessac Cedex 9, France.
authors: Xiaoshuang
authors: X
authors: Feng
authors: Elliot L
authors: EL
authors: Chaikof
authors: Christelle
authors: C
authors: Absalon
authors: Carlos
authors: C
authors: Drummond
authors: Daniel
authors: D
authors: Taton
authors: Yves
authors: Y
authors: Gnanou
mesh_terms: D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000295:instrumentation*; D008970:Molecular Weight; D011092:Polyethylene Glycols / Q000737:chemistry*
chemical_list: D050091:Dendrimers; D004337:Drug Carriers; D011092:Polyethylene Glycols