title: Classification of protein aggregates.
abstract: Comparison of protein aggregates/self-associated species between laboratories and across disciplines is complicated by the imprecise language presently used to describe them. In this commentary, we propose a standardized nomenclature and classification scheme that can be applied to describe all protein aggregates. Five categories are described under which a given aggregate may be independently classified: size, reversibility/dissociation, conformation, covalent modification, and morphology. Possible subclassifications within each category, several examples of applications of the nomenclature, and difficulties in making appropriate assignments will be discussed.
authors: Amgen Inc., Thousand Oaks, California, USA. lnarhi@amgen.com
authors: Linda O
authors: LO
authors: Narhi
authors: Jeremy
authors: J
authors: Schmit
authors: Karoline
authors: K
authors: Bechtold-Peters
authors: Deepak
authors: D
authors: Sharma
mesh_terms: D007753:Laboratories; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000145:classification; D015203:Reproducibility of Results
chemical_list: D011506:Proteins