title: Synthesis of novel thiazolyl-pyrimidines and their anticancer activity in vitro.
abstract: A series of novel compounds 7-43 were prepared via the condensation of enaminones 4a-h and the guanidines carbonate 6a-f. The structures of these newly synthesized compounds were confirmed by (1) H-NMR, MS, EA and IR. All the compounds were tested for their cytotoxic activity in vitro against human cancer cell lines including Ishikawa, A549, BEL-7404, SPC-A-01 and SGC-7901. Most of them showed moderate cytotoxic against the tested cell lines. Among them, the most potent compounds 9 and 30 exhibited more efficient activity against Ishikawa, A549.
authors: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, P.R. China.
authors: Hai-Bo
authors: HB
authors: Shi
authors: Hai-Bo
authors: HB
authors: Li
authors: Kong-Qin
authors: KQ
authors: Lu
authors: Xia-Re
authors: XR
authors: Zhu
authors: Wei-Xiao
authors: WX
authors: Hu
authors: Wen
authors: W
authors: Pei
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: C550465:4-methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine; D000970:Antineoplastic Agents; D011743:Pyrimidines; D013844:Thiazoles