title: Chemical composition, antinociceptive and anti-inflammatory properties of essential oil from the roots of Illicium lanceolatum.
abstract: Illicium lanceolatum is a popular aromatic and medicinal plant in China. Essential oil from the roots of I. lanceolatum, obtained by hydrodistillation, was analysed by GC-MS. The essential oil was dominated by phenylpropenes. The major components were myristicin (17.63%), α-asarone (17.23%), methyl isoeugenol (11.19%), apiol (8.82%) and isolongifolol (5.94%). When investigated using acetic acid-induced abdominal writhe models and the xylene-induced ear oedema model, the essential oil showed significantly antinociceptive and anti-inflammatory effects. The results indicate that the essential oil may contain the bioactive components of I. lanceolatum. This is the first report on the chemistry, antinociceptive and anti-inflammatory activities of I. lanceolatum.
authors: School of Pharmacy, Second Military Medical University, Shanghai, China. hbkcn@163.com
authors: Jie
authors: J
authors: Liang
authors: Baokang
authors: B
authors: Huang
authors: Guowei
authors: G
authors: Wang
mesh_terms: D000700:Analgesics / Q000737:chemistry* / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000627:therapeutic use*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D029523:Illicium / Q000737:chemistry*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009822:Oils, Volatile / Q000737:chemistry* / Q000627:therapeutic use*; D018517:Plant Roots / Q000737:chemistry*; D014992:Xylenes / Q000494:pharmacology
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D009822:Oils, Volatile; D014992:Xylenes