title: Maternal manganese restriction increases susceptibility to high-fat diet-induced dyslipidemia and altered adipose function in WNIN male rat offspring.
abstract: Growth in utero is largely a reflection of nutrient and oxygen supply to the foetus. We studied the effects of Mn restriction per se, maternal Mn restriction, and postnatal high-fat feeding in modulating body composition, lipid metabolism and adipocyte function in Wistar/NIN (WNIN) rat offspring. Female weanling, WNIN rats received ad libitum for 4 months, a control or Mn-restricted diet and were mated with control males. Some restricted mothers were rehabilitated with control diet from conception (MnRC) or parturition (MnRP), and their offspring were raised on control diet. Some restricted offspring were weaned onto control diet (MnRW), while others continued on restricted diet throughout (MnR). A set of offspring from each group was fed high-fat diet from 9 months onwards. Body composition, adipocytes function, and lipid metabolism were monitored in male rat offspring at regular intervals. Maternal manganese restriction increased the susceptibility of the offspring to high-fat-induced adiposity, dyslipidaemia, and a proinflammatory state but did not affect their glycemic or insulin status.
authors: Division of Endocrinology and Metabolism, National Institute of Nutrition, Hyderabad 500 604, India.
authors: Manisha
authors: M
authors: Ganeshan
authors: Pothaganti B
authors: PB
authors: Sainath
authors: Inagadapa J Naga
authors: IJ
authors: Padmavathi
authors: Lagishetty
authors: L
authors: Venu
authors: Yedla Durga
authors: YD
authors: Kishore
authors: Kalle Anand
authors: KA
authors: Kumar
authors: Nemani
authors: N
authors: Harishanker
authors: J Srinivasa
authors: JS
authors: Rao
authors: Manchala
authors: M
authors: Raghunath
mesh_terms: D017667:Adipocytes / Q000378:metabolism*; D050154:Adiposity; D000818:Animals; D004041:Dietary Fats / Q000009:adverse effects*; D004198:Disease Susceptibility; D050171:Dyslipidemias / Q000209:etiology* / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D005260:Female; D007333:Insulin Resistance; D007774:Lactation; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D008345:Manganese / Q000008:administration & dosage / Q000172:deficiency*; D039382:Maternal Nutritional Physiological Phenomena; D009765:Obesity / Q000209:etiology* / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D011247:Pregnancy; D051381:Rats; D011922:Rats, Mutant Strains; D017208:Rats, Wistar
chemical_list: D004041:Dietary Fats; D008055:Lipids; D008345:Manganese