title: Treatment of hematologic malignancies with immunotoxins and antibody-drug conjugates.
abstract: To enable antibodies to function as cytotoxic anticancer agents, they are modified either via attachment to protein toxins or highly potent, low-molecular-weight drugs. Such molecules, termed immunotoxins and antibody-drug conjugates, respectively, represent a second revolution in antibody-mediated cancer therapy. Thus, highly toxic compounds are delivered to the interior of cancer cells based on antibody specificity for cell-surface target antigens.
authors: Laboratory of Molecular Biology, National Cancer Institute, NIH, Bethesda, Maryland 20892-4264, USA.
authors: David J
authors: DJ
authors: FitzGerald
authors: Alan S
authors: AS
authors: Wayne
authors: Robert J
authors: RJ
authors: Kreitman
authors: Ira
authors: I
authors: Pastan
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D018941:Antigens, CD19 / Q000276:immunology; D015214:Antigens, Differentiation, Myelomonocytic / Q000276:immunology; D000970:Antineoplastic Agents / Q000276:immunology / Q000627:therapeutic use*; D001427:Bacterial Toxins / Q000627:therapeutic use; D017252:CD3 Complex / Q000276:immunology; D002986:Clinical Trials as Topic; D005098:Exotoxins / Q000627:therapeutic use; D019337:Hematologic Neoplasms / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D000922:Immunotoxins / Q000737:chemistry / Q000276:immunology / Q000627:therapeutic use*; D053650:Interleukin-3 Receptor alpha Subunit / Q000276:immunology; D051379:Mice; D015375:Receptors, Interleukin-2 / Q000276:immunology; D051918:Sialic Acid Binding Ig-like Lectin 2 / Q000276:immunology; D063268:Sialic Acid Binding Ig-like Lectin 3; D053668:Syndecan-1 / Q000276:immunology
chemical_list: D015703:Antigens, CD; D018941:Antigens, CD19; D015214:Antigens, Differentiation, Myelomonocytic; D000970:Antineoplastic Agents; D001427:Bacterial Toxins; C497867:CD22 protein, human; D017252:CD3 Complex; C571163:CD33 protein, human; C571165:Cd33 protein, mouse; D005098:Exotoxins; C115022:IL3RA protein, human; D000922:Immunotoxins; D053650:Interleukin-3 Receptor alpha Subunit; D015375:Receptors, Interleukin-2; C508241:SDC1 protein, human; D051918:Sialic Acid Binding Ig-like Lectin 2; D063268:Sialic Acid Binding Ig-like Lectin 3; D053668:Syndecan-1; C541974:immunotoxin HA22