title: A ferrocenyl-DHIPOH/Cu(OAc)2 complex for diastereo- and enantioselective catalysis of the 1,4-addition of glycine derivatives to alkylidene malonates.
abstract: A planar chiral ferrocene derivative Fc-DHIPOH served as an excellent N,O- chiral ligand for asymmetric copper catalyzed 1,4-addition of glycine derivatives to alkylidene malonates. The corresponding 1,4-adducts were obtained in high yields with excellent enantioselectivities up to 95% ee.
authors: Shanghai Key Laboratory of Functional Materials Chemistry & School of Pharmacy, East China University of Science and Technology, Shanghai, China, 200237.
authors: Yu-Hua
authors: YH
authors: Shi
authors: Zheng
authors: Z
authors: Wang
authors: Bin
authors: B
authors: Hu
authors: Ming
authors: M
authors: Wang
authors: John S
authors: JS
authors: Fossey
authors: Wei-Ping
authors: WP
authors: Deng
mesh_terms: D000478:Alkylation; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D005296:Ferrous Compounds / Q000737:chemistry*; D005998:Glycine / Q000737:chemistry*; D008024:Ligands; D008314:Malonates / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D005296:Ferrous Compounds; D008024:Ligands; D008314:Malonates; D003300:Copper; D005998:Glycine