title: Lutein and zeaxanthin supplementation in preterm infants to prevent retinopathy of prematurity: a randomized controlled study.
abstract: Lutein and its isomer zeaxanthin (L/Z) function in the eye as antioxidant agents and blue-light filters. Our aim was to evaluate whether their administration could help decrease the occurrence of retinopathy of prematurity (ROP) in preterm infants.
  
  
  
  Infants with gestational age ≤32 weeks were randomly assigned to receive a daily dose of L/Z (0.14 + 0.006 mg) or placebo until discharge.
  
  
  
  ROP occurrence was similar in the L/Z (11/58; 19%) and placebo (15/56; 27%) groups, as the occurrence of ROP at each stage and the need of eye surgery.
  
  
  
  L/Z supplementation was ineffective in preventing ROP in preterm infants and did not affect the outcome at discharge of our patients.
authors: Department of Surgical and Medical Critical Care, Section of Neonatology, Careggi University Hospital of Florence, Florence, Italy. cdani@unifi.It
authors: Carlo
authors: C
authors: Dani
authors: Ilaria
authors: I
authors: Lori
authors: Federica
authors: F
authors: Favelli
authors: Saverio
authors: S
authors: Frosini
authors: Hubert
authors: H
authors: Messner
authors: Petra
authors: P
authors: Wanker
authors: Sergio
authors: S
authors: De Marini
authors: Chiara
authors: C
authors: Oretti
authors: Antonio
authors: A
authors: Boldrini
authors: Massimiliano
authors: M
authors: Ciantelli
authors: Patrizia
authors: P
authors: Bragetti
authors: Cristiana
authors: C
authors: Germini
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D016015:Logistic Models; D014975:Lutein / Q000627:therapeutic use*; D008297:Male; D012178:Retinopathy of Prematurity / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D012307:Risk Factors; D016896:Treatment Outcome; D024341:Xanthophylls / Q000627:therapeutic use*; D065146:Zeaxanthins
chemical_list: D000975:Antioxidants; D004338:Drug Combinations; D024341:Xanthophylls; D065146:Zeaxanthins; D014975:Lutein