title: Clindamycin release determined by high performance liquid chromatography from a novel low-cost local drug delivery system: a new potential treatment option for chronic osteomyelitis.
abstract: Osteomyelitis continues to be a severe problem worldwide, causing plenty of hospital admissions and entailing vast expenses. Previously, we developed a low-cost polymethyl-methacrylate (PMMA)-sorbitol based capsule system for local long-term drug delivery. In the present study we aimed to test the in vitro release of clindamycin capsules by high performance liquid chromatography. By the end of the clinically relevant period (42 days), the capsules released 70-100% of their load. Furthermore, the release kinetics suggested that an effective antimicrobial concentration may be maintained within the target area. Our findings indicate that these newly developed capsules may be a versatile device for local clindamycin delivery by providing efficient release and reducing financial burdens.
authors: Department of Laboratory Medicine, Faculty of Medicine, University of Pécs, Pécs, Hungary.
authors: D
authors: D
authors: Frank
authors: G
authors: G
authors: Montskó
authors: I
authors: I
authors: Juricskay
authors: B
authors: B
authors: Borsiczky
authors: G
authors: G
authors: Cseh
authors: B
authors: B
authors: Kocsis
authors: T
authors: T
authors: Nagy
authors: Á K
authors: ÁK
authors: Nagy
authors: G L
authors: GL
authors: Kovács
authors: A
authors: A
authors: Miseta
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry* / Q000191:economics; D002214:Capsules; D002851:Chromatography, High Pressure Liquid; D002908:Chronic Disease; D002981:Clindamycin / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry* / Q000191:economics; D003692:Delayed-Action Preparations / Q000191:economics; D004339:Drug Compounding; D016503:Drug Delivery Systems / Q000191:economics; D017048:Health Care Costs; D007700:Kinetics; D010019:Osteomyelitis / Q000188:drug therapy* / Q000191:economics; D019904:Polymethyl Methacrylate / Q000737:chemistry; D012995:Solubility; D013012:Sorbitol / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D002214:Capsules; D003692:Delayed-Action Preparations; D002981:Clindamycin; D013012:Sorbitol; D019904:Polymethyl Methacrylate