title: Hypothalamic-pituitary-adrenal axis suppression related to topical glucocorticoid therapy in a child with psoriatic exfoliative erythroderma.
abstract: Exfoliative erythroderma is a rare presentation of psoriasis in children and adults. We report a 9-year-old girl with exfoliative erythroderma secondary to plaque-type psoriasis who developed hypothalamic-pituitary-adrenal axis suppression resulting from topical treatment with a medium-potency glucocorticoid. This case emphasizes the need for awareness of this potentially life-threatening complication of topical glucocorticoid use, particularly in patients who have significant compromise of barrier function secondary to widespread skin disease.
authors: Department of Dermatology, Rush University Medical Center, Chicago, Illinois 60612, USA. Lauren_Campbell@rush.edu
authors: Lauren S
authors: LS
authors: Campbell
authors: Michelle
authors: M
authors: Chevalier
authors: Richard A
authors: RA
authors: Levy
authors: Arthur
authors: A
authors: Rhodes
mesh_terms: D000287:Administration, Topical; D002648:Child; D003873:Dermatitis, Exfoliative / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects* / Q000503:physiopathology; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects; D010913:Pituitary-Adrenal System / Q000187:drug effects* / Q000503:physiopathology; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents