title: [A case of gastric cancer with liver metastasis had a good reaction to S-1/CDDP chemotherapy after S-1 chemotherapy was ineffective].
abstract: A woman in her sixties underwent total gastrectomy for gastric cancer. The pathological diagnosis was pT3, pN3, sH0, pCY0, sP0, sM0, fStage IV. Chemotherapy with S-1 was used after surgical treatment. Because a CT scan after three courses chemotherapy showed the paraaortic lymph nodes swelling, combination chemotherapy with S-1 and docetaxel was used as a second-line chemotherapy. When the CT scan after 8 courses of this combination chemotherapy revealed multiple liver metastases, the chemotherapy was changed to CPT-11 monotherapy and paclitaxel monotherapy as the third-and fourth-line chemotherapy, respectively. In spite of those chemotherapies, the metastatic disease progressed, and therefore, combination chemotherapy with S-1 and CDDP was used as the fifth-line chemotherapy. After 6 courses of this treatment, serum CEA and CA19-9 levels dropped into the normal range. Multiple liver metastases were markedly reduced, and were considered as a partial response(PR). The patient is still alive, maintaining the effect of PR for 17 months without any adverse effects except appetite loss and vomiting of grade 2.
authors: Department of Surgery, Kansai Rosai Hospital, Japan.
authors: Kumiko
authors: K
authors: Uji
authors: Shigeyuki
authors: S
authors: Tamura
authors: Atsushi
authors: A
authors: Takeno
authors: Hirofumi
authors: H
authors: Miki
authors: Takashi
authors: T
authors: Kanemura
authors: Ayako
authors: A
authors: Yanai
authors: Masayoshi
authors: M
authors: Kobayashi
authors: Yasumasa
authors: Y
authors: Yoshioka
authors: Atsuko
authors: A
authors: Teramoto
authors: Shin
authors: S
authors: Nakahira
authors: Rei
authors: R
authors: Suzuki
authors: Ken
authors: K
authors: Nakata
authors: Chiyomi
authors: C
authors: Egawa
authors: Syu
authors: S
authors: Okamura
authors: Keishi
authors: K
authors: Sugimoto
authors: Yuichi
authors: Y
authors: Takatsuka
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D004338:Drug Combinations; D004357:Drug Synergism; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D010094:Oxonic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D016879:Salvage Therapy; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005641:Tegafur / Q000008:administration & dosage / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin