title: Green synthesis and antimicrobial evaluation of some new trifluoromethyl-substituted hexahydropyrimidines by grinding.
abstract: A series of trifluoromethyl-substituted hexahydropyrimidine derivatives were efficiently synthesized in excellent yields via one-pot three-component reaction of aromatic aldehydes, ethyl trifluoroacetoacetate and thiourea(urea) in presence of p-toluenesulfonic acid under solvent-free conditions at room temperature by grinding. The present method does not involve any hazardous organic solvent and has proven to be simple, efficient, environmentally benign and cost-effective compared with the classical synthetic methods. These compounds were screened for their antibacterial activities against Escherichia coli and Bacillus thuringiensis and found to exhibit remarkably better antibacterial activities than the control drug.
authors: Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt. zohdi@cu.edu.eg
authors: Hussein F
authors: HF
authors: Zohdi
authors: Nora M
authors: NM
authors: Rateb
authors: Sherif M
authors: SM
authors: Elnagdy
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001413:Bacillus thuringiensis / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D004926:Escherichia coli / Q000187:drug effects; D055772:Green Chemistry Technology / Q000379:methods*; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008968:Molecular Conformation; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D011743:Pyrimidines