title: Poxvirus exploitation of the ubiquitin-proteasome system.
abstract: Ubiquitination plays a critical role in many cellular processes. A growing number of viruses have evolved strategies to exploit the ubiquitin-proteasome system, including members of the Poxviridae family. Members of the poxvirus family have recently been shown to encode BTB/kelch and ankyrin/F-box proteins that interact with cullin-3 and cullin-1 based ubiquitin ligases, respectively. Multiple members of the poxvirus family also encode ubiquitin ligases with intrinsic activity. This review describes the numerous mechanisms that poxviruses employ to manipulate the ubiquitin-proteasome system.
authors: Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, T6G 2S2, Canada.
authors: Michele
authors: M
authors: Barry
authors: Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, T6G 2S2, Canada.
authors: Nicholas
authors: N
authors: Van Buuren
authors: Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, T6G 2S2, Canada.
authors: Kristin
authors: K
authors: Burles
authors: Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, T6G 2S2, Canada.
authors: Kelly
authors: K
authors: Mottet
authors: Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, T6G 2S2, Canada.
authors: Qian
authors: Q
authors: Wang
authors: Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, T6G 2S2, Canada.
authors: Alastair
authors: A
authors: Teale