title: Aquaporin-4-dependent edema clearance following status epilepticus.
abstract: We investigated the role of aquaporin-4 in the development of cerebral edema following kainic acid-induced status epilepticus (SE) using specific gravimetry and T2 MRI techniques at 6 h, 1 day, 4 days and 7 days after SE. Our results indicate significantly greater tissue edema and T2 MRI changes in AQP4(-/-) compared to AQP4(+/+) mice that peaks at about 1 day after SE (greater in hippocampus relative to cortex). These results have implications for the mechanisms of edema formation and clearance following intense seizure activity.
authors: Department of Neurological Surgery, University of California, Davis, CA, United States.
authors: Darrin J
authors: DJ
authors: Lee
authors: Mariam
authors: M
authors: Amini
authors: Mark J
authors: MJ
authors: Hamamura
authors: Mike S
authors: MS
authors: Hsu
authors: Marcus M
authors: MM
authors: Seldin
authors: Orhan
authors: O
authors: Nalcioglu
authors: Devin K
authors: DK
authors: Binder
mesh_terms: D000818:Animals; D051401:Aquaporin 4 / Q000172:deficiency / Q000378:metabolism*; D001929:Brain Edema / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000378:metabolism; D004195:Disease Models, Animal; D006624:Hippocampus / Q000378:metabolism; D007608:Kainic Acid / Q000633:toxicity; D008279:Magnetic Resonance Imaging; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D013226:Status Epilepticus / Q000139:chemically induced / Q000150:complications*; D013997:Time Factors; D014867:Water / Q000378:metabolism
chemical_list: D051401:Aquaporin 4; D014867:Water; D007608:Kainic Acid