title: Non-invasive optical imaging of stroke.
abstract: The acute onset of a neurological deficit is the key clinical feature of stroke. In most cases, however, pathophysiological changes in the cerebral vasculature precede the event, often by many years. Persisting neurological deficits may also require long-term rehabilitation. Hence, stroke may be considered a chronic disease, and diagnostic and therapeutic efforts must include identification of specific risk factors, and the monitoring of and interventions in the acute and subacute stages, and should aim at a pathophysiologically based approach to optimize the rehabilitative effort. Non-invasive optical techniques have been experimentally used in all three stages of the disease and may complement the established diagnostic and monitoring tools. Here, we provide an overview of studies using the methodology in the context of stroke, and we sketch perspectives of how they may be integrated into the assessment of the highly dynamic pathophysiological processes during the acute and subacute stages of the disease and also during rehabilitation and (secondary) prevention of stroke.
authors: Department of Cognitive Neurology, University Hospital Leipzig, Liebigstraße 16, 04103 Leipzig, Germany. obrig@cbs.mpg.de
authors: Hellmuth
authors: H
authors: Obrig
authors: Jens
authors: J
authors: Steinbrink
mesh_terms: D001921:Brain / Q000473:pathology; D002560:Cerebrovascular Circulation; D002908:Chronic Disease; D003952:Diagnostic Imaging / Q000379:methods*; D003576:Electron Transport Complex IV / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D010477:Perfusion; D012307:Risk Factors; D019265:Spectroscopy, Near-Infrared / Q000379:methods; D020521:Stroke / Q000175:diagnosis / Q000503:physiopathology* / Q000517:prevention & control; D000071939:Stroke Rehabilitation; D013997:Time Factors
chemical_list: D006454:Hemoglobins; D003576:Electron Transport Complex IV