title: Growth hormone deficiency: an unusual presentation of floating harbor syndrome.
abstract: Floating-Harbor Syndrome (FHS) is a very rare condition of unknown etiology characterized by short stature, delayed bone age, characteristic facial features, delayed language skills and usually normal motor development. This syndrome has only once been associated with growth hormone deficiency and precocious puberty in the same patient. We describe a 5 4/12 year-old girl with the typical features of FHS in whom growth hormone deficiency was diagnosed and two years later central precocious puberty was noted. The patient showed a good response to human recombinant growth hormone as well as gonadotropin releasing hormone analogue treatment.
authors: Fourth Department of Pediatrics, Medical School, Aristotle University of Thessaloniki, Papageorgiou General Hospital Thessaloniki, Greece. galtsin@otenet.gr
authors: Assimina
authors: A
authors: Galli-Tsinopoulou
authors: Ioannis
authors: I
authors: Kyrgios
authors: Eleftheria
authors: E
authors: Emmanouilidou
authors: Ioanna
authors: I
authors: Maggana
authors: Eleni
authors: E
authors: Kotanidou
authors: Paraskevi
authors: P
authors: Kokka
authors: Charilaos
authors: C
authors: Stylianou
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis* / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D019465:Craniofacial Abnormalities / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D003937:Diagnosis, Differential; D004393:Dwarfism, Pituitary / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000627:therapeutic use; D006130:Growth Disorders / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D006345:Heart Septal Defects, Ventricular / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D019382:Human Growth Hormone / Q000172:deficiency* / Q000627:therapeutic use; D006801:Humans; D011629:Puberty, Precocious / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology
chemical_list: D019382:Human Growth Hormone; D007987:Gonadotropin-Releasing Hormone