title: The association between common genetic variant of microRNA-146a and cancer susceptibility.
abstract: Published data on the association between microRNA-146a (miR-146a) G/C polymorphism and cancer susceptibility are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 23 studies including 10,585 cases and 12,183 controls were used in the meta-analysis. Overall, no significant associations were found between miR-146a G/C polymorphism and cancer risk when all studies pooled into the meta-analysis (GC vs. CC: OR=1.08, 95% CI=0.94-1.24; GG vs. CC: OR=1.13, 95% CI=0.93-1.37; dominant model: OR=1.09, 95% CI=0.94-1.26). In the subgroup analysis by ethnicity, still no significant associations were found. In the subgroup analysis by cancer type, statistically significantly increased risks were found for papillary thyroid carcinoma (GC vs. CC: OR=3.44, 95% CI=1.86-6.34; GG vs. CC: OR=2.20, 95% CI=1.22-3.99; dominant model: OR=2.68, 95% CI=1.48-4.83). In the subgroup analysis by population-based controls or hospital-based controls, no statistically significantly increased risks were found. Despite some limitations, this meta-analysis suggests that the miR-146a G allele is a low-penetrant risk factor for papillary thyroid carcinoma development.
authors: Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China. mdqiulixin@hotmail.com
authors: Li-Xin
authors: LX
authors: Qiu
authors: Jing
authors: J
authors: He
authors: Meng-Yun
authors: MY
authors: Wang
authors: Ruo-Xin
authors: RX
authors: Zhang
authors: Ting-Yan
authors: TY
authors: Shi
authors: Mei-Ling
authors: ML
authors: Zhu
authors: Chen
authors: C
authors: Mao
authors: Si
authors: S
authors: Sun
authors: Fang-Fang
authors: FF
authors: Lv
authors: Chun-Lei
authors: CL
authors: Zheng
authors: Xiao-Dong
authors: XD
authors: Zhu
mesh_terms: D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias
chemical_list: C542542:MIRN146 microRNA, human; D035683:MicroRNAs