title: [T-cells in ANCA-associated vasculitis].
abstract: CD4+NKG2D+effector memory T-cell-mediated endothelial cell damage and a Th17 dominated cytokine profile of PR3-specific T-cells may play an important role in the pathogenesis of granulomatosis with polyangiitis (Wegener's). The anti-IL-5 antibody mepolizumab (anti-IL-5) induces remission in Churg-Strauss syndrome.
authors: Poliklinik für Rheumatologie, Vaskulitiszentrum UKSH & Klinikum Bad Bramstedt, Universität zu Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland. peter.lamprecht@uk-sh.de
authors: P
authors: P
authors: Lamprecht
authors: D
authors: D
authors: Kabelitz
mesh_terms: D000818:Animals; D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000188:drug therapy / Q000276:immunology*; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000276:immunology; D016175:B-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D015267:Churg-Strauss Syndrome / Q000188:drug therapy / Q000276:immunology; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000187:drug effects / Q000276:immunology; D004804:Eosinophils / Q000187:drug effects / Q000276:immunology; D005921:Glomerulonephritis / Q000188:drug therapy / Q000276:immunology; D006098:Granulocytes / Q000187:drug effects / Q000276:immunology; D014890:Granulomatosis with Polyangiitis / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology*; D015848:Interleukin-5 / Q000097:blood; D051379:Mice; D055655:NK Cell Lectin-Like Receptor Subfamily K / Q000276:immunology; D012074:Remission Induction; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D058504:Th17 Cells / Q000187:drug effects / Q000276:immunology; D018418:Th2 Cells / Q000187:drug effects / Q000276:immunology
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D015848:Interleukin-5; C527085:KLRK1 protein, human; D055655:NK Cell Lectin-Like Receptor Subfamily K; C434107:mepolizumab