title: Congenital disorders of the thyroid: hypo/hyper.
abstract: This article summarizes the ontogenesis and genetics of the thyroid with regards to its possible congenital dysfunction and briefly refers to the roles of the mother-placenta-fetal unit, iodine effect, and organic and functional changes of the negative feedback mechanism, as well as maturity and illness, in some forms of congenital hypo- and hyperthyroidism. This article also describes the published literature and the authors' data on the clinical aspects of congenital hypothyroidism, on the alternating hypo- and hyperthyroidism in the neonatal period, and on neonatal hyperthyroidism.
authors: Department of Pediatrics, Division of Endocrinology, St Johns Hospital and United Hospitals of North-Buda, Buda Children's Hospital, 1023 Bolyai-u. 5-9 Budapest, Hungary. peter_f@budaigyk.hu
authors: Ferenc
authors: F
authors: Péter
authors: Agota
authors: A
authors: Muzsnai
mesh_terms: D000465:Algorithms; D013956:Antithyroid Agents / Q000627:therapeutic use; D003409:Congenital Hypothyroidism / Q000175:diagnosis / Q000196:embryology / Q000235:genetics / Q000628:therapy; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000151:congenital* / Q000175:diagnosis / Q000188:drug therapy / Q000196:embryology; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D013963:Thyroid Hormones / Q000627:therapeutic use
chemical_list: D013956:Antithyroid Agents; D013963:Thyroid Hormones