title: Using the modern Silverhawk™ atherectomy catheter to characterize biliary structures that appear malignant: review of initial experience.
abstract: BACKGROUND
  Diagnosis of a biliary stricture often hinges on cytological interpretation. In the absence of accompanying stroma, these results can often be equivocal. In theory, advanced shave biopsy techniques would allow for the preservation of tissue architecture and a more accurate definition of biliary pathology.
  
  
  OBJECTIVE
  We sought to determine the initial diagnostic utility of the modern Silverhawk™ atherectomy (SA) catheter in the evaluation of biliary strictures that appear to be malignant.
  
  
  METHODS
  A total of 141 patients with biliary pathology were identified during a retrospective review of medical records for the years 2006-2011. The SA catheter was employed 12 times in seven patients for whom a tissue diagnosis was otherwise lacking.
  
  
  RESULTS
  Neoplasia was definitively excluded in seven specimens from four patients. These four individuals were followed for 1-5 years to exclude the development of cholangiocarcinoma (CC). Samples were positive for CC in three patients, one of whom became eligible for neoadjuvant therapy and orthotopic liver transplantation.
  
  
  CONCLUSIONS
  The SA catheter appears to be a useful adjunct in diagnosing patients with biliary pathology. The existence of this technique, predicated on tissue architecture, may impact therapy, allow more timely diagnosis, and exclude cases of equivocal cytology. Although the initial results of SA use are promising, more experience is required to effectively determine its clinical accuracy.
authors: Department of General Surgery, Section of Transplantation, University of Utah School of Medicine, Salt Lake City, USA. jason.schwartz@hsc.utah.edu
authors: Jason J
authors: JJ
authors: Schwartz
authors: Heather F
authors: HF
authors: Thiesset
authors: Frederic
authors: F
authors: Clayton
authors: Douglas G
authors: DG
authors: Adler
authors: William R
authors: WR
authors: Hutson
authors: James G
authors: JG
authors: Carlisle
mesh_terms: D000368:Aged; D017073:Atherectomy / Q000295:instrumentation*; D001650:Bile Duct Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D001653:Bile Ducts, Intrahepatic / Q000473:pathology*; D001706:Biopsy / Q000295:instrumentation*; D057785:Catheters; D018281:Cholangiocarcinoma / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D002779:Cholestasis / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D003251:Constriction, Pathologic; D004867:Equipment Design; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D014589:Utah