title: Candida in oral pre-cancer and oral cancer.
abstract: Oral pre-malignancies and carcinomas are common epithelial pathologies caused by a variety of etiological factors. In the oral cavity, candidiasis is the most frequent opportunistic fungal infection. Since the initial reports of an association between candidiasis with oral pre-cancer and cancer, various theories have been debated regarding the role of candida in development and transformation of oral pre-malignancies. However, the exact role is still unclear. In the present article, we hypothesize a causal role for candidiasis in oral pre-cancer and cancer albeit an indirect one. We also suggest that candida along with other co-factors may play a role in initiation and promotion of carcinogenesis.
authors: Department of Oral Pathology and Microbiology, Drs Sudha and Nageshwara Rao Siddhartha Institute of Dental Sciences and Hospital, Chinnaouutpalli, Gannavaram Mandal 521 286, Vijayawada, Krishna District, Andhra Pradesh, India. drsanjaynayak@gmail.com
authors: P R
authors: PR
authors: Sanjaya
authors: S
authors: S
authors: Gokul
authors: B
authors: B
authors: Gururaj Patil
authors: Ramanjeneya
authors: R
authors: Raju
mesh_terms: D002176:Candida albicans / Q000378:metabolism* / Q000472:pathogenicity; D002177:Candidiasis / Q000150:complications*; D006801:Humans; D008954:Models, Biological; D009061:Mouth Mucosa / Q000378:metabolism; D009062:Mouth Neoplasms / Q000209:etiology / Q000382:microbiology*; D009602:Nitrosamines / Q000378:metabolism; D015538:Nitrosation; D011230:Precancerous Conditions / Q000209:etiology / Q000382:microbiology*
chemical_list: D009602:Nitrosamines