title: Sustained clinical efficacy of sublingual immunotherapy with a high-dose grass pollen extract.
abstract: BACKGROUND
  Sublingual immunotherapy (SLIT) with a high-dose 6-grass pollen SingleDose preparation was shown to be effective and safe in a 2-year randomized, double-blind, placebo-controlled trial.
  
  
  OBJECTIVE
  We evaluated the effect of the third year of SLIT in comparison to the second year.
  
  
  METHODS
  46 grass pollen-allergic patients who had received active treatment for 3 consecutive years were included in the safety set. Diary data from 39 subjects were evaluated to calculate symptom and medication scores as well as 'well days'.
  
  
  RESULTS
  Symptoms and medication intake further decreased in the third year of SLIT during the grass pollen season in comparison to the previous years and the number of 'well days' increased accordingly. No serious adverse events occurred during the three years of SLIT.
  
  
  CONCLUSIONS
  The third year of SLIT with the high-dose 6-grass pollen preparation results in sustained and even further increased clinical efficacy.
authors: Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lódz, Poland. pkuna@barlicki.internetdsl.pl
authors: P
authors: P
authors: Kuna
authors: B
authors: B
authors: Samolinski
authors: M
authors: M
authors: Worm
authors: O
authors: O
authors: Pfaar
authors: L
authors: L
authors: Klimek
mesh_terms: D000286:Administration, Sublingual; D000328:Adult; D000485:Allergens / Q000008:administration & dosage* / Q000009:adverse effects; D001249:Asthma / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D003231:Conjunctivitis; D003888:Desensitization, Immunologic; D018450:Disease Progression; D054796:Drug Dosage Calculations; D005500:Follow-Up Studies; D006801:Humans; D010936:Plant Extracts / Q000008:administration & dosage* / Q000009:adverse effects; D006109:Poaceae; D011058:Pollen / Q000009:adverse effects; D012220:Rhinitis; D006255:Rhinitis, Allergic, Seasonal / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000485:Allergens; D010936:Plant Extracts