title: Effect of corpus callosotomy on attention deficit and behavioral problems in pediatric patients with intractable epilepsy.
abstract: To evaluate the effect of corpus callosotomy (CC) on attention deficit and behavioral problems in pediatric patients with intractable epilepsy, we retrospectively investigated sequential patients who had undergone CC to control seizures. Between August 2005 and April 2010, a total of 15 patients aged between 3.1 and 17.9 years underwent CC at our institute. All the patients experienced either drop attacks or head nodding, which were considered to be therapeutic targets of CC. A standardized instrument, the Child Behavior Checklist (CBCL), was used to assess behavioral and emotional problems before and after surgery. On postoperative EEGs, 8 (53%) showed improvement and 7 (47%) showed no change in epileptiform discharges. The Attention Problems scale and total score on the CBCL significantly improved in patients whose postoperative EEGs showed improvement. In addition to amelioration of target seizures, CC can improve attention impairments in association with improvement in the postoperative EEG.
authors: Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan. yonekawa@ncnp.go.jp
authors: Takahiro
authors: T
authors: Yonekawa
authors: Eiji
authors: E
authors: Nakagawa
authors: Eri
authors: E
authors: Takeshita
authors: Yuki
authors: Y
authors: Inoue
authors: Masumi
authors: M
authors: Inagaki
authors: Makiko
authors: M
authors: Kaga
authors: Kenji
authors: K
authors: Sugai
authors: Masayuki
authors: M
authors: Sasaki
authors: Takanobu
authors: T
authors: Kaido
authors: Akio
authors: A
authors: Takahashi
authors: Taisuke
authors: T
authors: Otsuki
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000209:etiology* / Q000601:surgery*; D057189:Checklist; D002648:Child; D002653:Child Behavior Disorders / Q000209:etiology* / Q000601:surgery*; D002675:Child, Preschool; D003337:Corpus Callosum / Q000502:physiology / Q000601:surgery*; D002658:Developmental Disabilities / Q000209:etiology / Q000601:surgery; D004569:Electroencephalography; D004827:Epilepsy / Q000150:complications* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D012189:Retrospective Studies; D016896:Treatment Outcome