title: Current status of the management of symptomatic intracranial atherosclerotic disease: the rationale for a randomized trial of medical therapy and intracranial stenting.
abstract: Stenting and Aggressive Medical Management for Preventing Recurrent stroke in Intracranial Stenosis (SAMMPRIS) is a randomized trial comparing aggressive medical management alone with aggressive medical management in combination with angioplasty and stenting using the Gateway-Wingspan system in patients with symptomatic, high-grade, intracranial stenosis. This trial represents a landmark in the maturation of the field of neurointervention, establishing a foundation for evidenced-based practice. We review the natural history of symptomatic intracranial stenosis when treated medically, the available interventional therapies and the rationale for the design of the SAMMPRIS trial.
authors: Department of Neurosurgery, Stony Brook University Medical Center, Stony Brook, New York, New York 11794-8122, USA. dfiorella@notes.cc.sunysb.edu
authors: D
authors: D
authors: Fiorella
authors: T N
authors: TN
authors: Turan
authors: C P
authors: CP
authors: Derdeyn
authors: M I
authors: MI
authors: Chimowitz
mesh_terms: D017130:Angioplasty; D000925:Anticoagulants / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000188:drug therapy / Q000601:surgery; D019317:Evidence-Based Medicine; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000188:drug therapy* / Q000601:surgery*; D016032:Randomized Controlled Trials as Topic; D015607:Stents; D020521:Stroke / Q000188:drug therapy / Q000601:surgery
chemical_list: D000925:Anticoagulants