title: Optic neuropathy associated with CANOMAD: description of 2 cases.
abstract: CANOMAD is a chronic ataxic neuropathy associated with IgM paraproteinemia and reactivity against disialosyl gangliosides. Ophthalmoplegia is a typical feature, but optic pathway involvement has not been reported previously. We describe 2 cases of CANOMAD associated with optic neuropathy. Severe visual loss was present in 1 case. We postulate that optic nerve damage may be related to antibody reactivity against gangliosides. Our report broadens the spectrum of cranial nerve involvement in this rare entity.
authors: Neuromuscular Clinic, Department of Neurology, University Hospitals of Leicester, Leicester LES 4PW, UK.
authors: Lara
authors: L
authors: Sanvito
authors: Yusuf A
authors: YA
authors: Rajabally
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications* / Q000503:physiopathology; D001259:Ataxia / Q000150:complications* / Q000503:physiopathology; D055724:Electrophysiological Phenomena; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D009886:Ophthalmoplegia / Q000150:complications* / Q000503:physiopathology; D009900:Optic Nerve / Q000503:physiopathology; D009901:Optic Nerve Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D013256:Steroids / Q000627:therapeutic use; D017211:Treatment Failure; D016896:Treatment Outcome; D014786:Vision Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology
chemical_list: D016756:Immunoglobulins, Intravenous; D013256:Steroids