title: Selectivity in C-alkylation of dianions of protected 6-methyluridine.
abstract: A regioselective synthesis of 6-ω-alkenyluridines 3, precursors of potent antiviral and antitumor cyclonucleosides 5, is described. While ω-alkenyl halides do not alkylate 6-lithiouridine, compounds 3 were prepared in a regioselective manner by sequential treatment of 6-methyluridine 2 with LTMP or LDA (4 equiv) in THF at -30 °C followed by alkylation with ω-alkenyl bromides.
authors: Université du Maine and CNRS, Unité de chimie organique moléculaire et macromoléculaire (UMR 6011), Faculté des sciences, avenue Olivier Messiaen, 72085 Le Mans Cedex 9, France.
authors: Ngoc Hoa
authors: NH
authors: Nguyen
authors: Christophe
authors: C
authors: Len
authors: Anne-Sophie
authors: AS
authors: Castanet
authors: Jacques
authors: J
authors: Mortier