title: A review of the role of mechanical forces in cutaneous wound healing.
abstract: Cutaneous wound healing is a complex process with many types of mechanical forces regulating the quality and speed of healing. The role of mechanical forces in regulating tissue growth, repair and remodelling was recognised more than a century ago. Such forces influence gene expression, the synthesis of growth factors and inflammatory mediators and cellular processes like proliferation of many load-sensitive cells. However, the exact mechanisms by which these forces interact with cells and ways to use them to stimulate tissues are still active research fronts. This article sets to review the literature on mechanical forces and their role in cutaneous wound healing.
authors: National Institute of Health and Clinical Excellence Scholar, Department of Vascular Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom. mail@riazagha.com
authors: Riaz
authors: R
authors: Agha
authors: Rei
authors: R
authors: Ogawa
authors: Giorgio
authors: G
authors: Pietramaggiori
authors: Dennis P
authors: DP
authors: Orgill
mesh_terms: D000818:Animals; D006801:Humans; D007627:Keloid / Q000503:physiopathology*; D018919:Neovascularization, Physiologic / Q000502:physiology; D012867:Skin / Q000098:blood supply / Q000293:injuries*; D012879:Skin Physiological Phenomena; D013314:Stress, Mechanical; D014945:Wound Healing / Q000502:physiology*