title: A straightforward approach towards combined α-amino and α-hydroxy acids based on Passerini reactions.
abstract: Complex amino acids with an α-acyloxycarbonyl functionality in the side chain are easily available through epoxide opening by chelated enolates and subsequent oxidation/Passerini reaction. This protocol works with both, aldehyde and ketone intermediates, as long as the ketones are activated by electron-withdrawing groups. In principle Ugi reactions are also possible, allowing the generation of diamino acid derivatives.
authors: Institute for Organic Chemistry, Saarland University, P.O. Box 151150, 66041 Saarbrücken, Germany.
authors: Ameer F
authors: AF
authors: Zahoor
authors: Sarah
authors: S
authors: Thies
authors: Uli
authors: U
authors: Kazmaier