title: Thick corpus callosum: a clue to the diagnosis of fetal septopreoptic holoprosencephaly?
abstract: We describe fetal septopreoptic holoprosencephaly (HPE) associated with a thick corpus callosum (CC) diagnosed with MRI in a fetus at 31 weeks' gestation. Our report supports a recently published study connecting a thick fetal CC to other brain abnormalities. On diffusion tensor imaging (DTI), the body of the CC contained an abnormal longitudinal bundle, presumed to be a congenital heterotopic cingulum. Prenatal and postmortem brain MRI with DTI, CT, and pathological analyses are described and illustrated.
authors: Radiopédiatrie, Radiologie 2, CHU Strasbourg-Hautepierre, 1 Avenue Molière, 67098, Strasbourg, France. meriam.koob@chru-strasbourg.fr
authors: Mériam
authors: M
authors: Koob
authors: Anne-sophie
authors: AS
authors: Weingertner
authors: Bernard
authors: B
authors: Gasser
authors: Estanislao
authors: E
authors: Oubel
authors: Jean-Louis
authors: JL
authors: Dietemann
mesh_terms: D003337:Corpus Callosum / Q000473:pathology*; D016142:Holoprosencephaly / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011296:Prenatal Diagnosis / Q000379:methods*; D025962:Septo-Optic Dysplasia / Q000473:pathology*