title: Notch1 signaling pathway participates in cancer invasion by regulating             MMPs in lingual squamous cell carcinoma.
abstract: Some studies show the Notch signaling pathway may participate in carcinoma             invasion and metastasis. However, the mechanisms by which Notch1 mediates cell             invasion and migration, especially in lingual squamous cell carcinoma, are not             yet known. In the current study, we demonstrated for the first time the anti-invasion             and anti-metastasis effect of down-regulation of Notch1 in lingual squamous cell             carcinoma. Down-regulation of Notch1 could be an effective approach for inhibition             of the expression of matrix metalloproteinase (MMP)-2 and MMP-9 resulting in the             inhibition of invasion and metastasis, which could be useful for devising novel             preventive and therapeutic strategies for lingual squamous cell carcinoma.
authors: Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, and Department of Pediatrics, Xijing Hospital, Xi'an, Shannxi 710032, PR China.
authors: Bo
authors: B
authors: Yu
authors: Jianhua
authors: J
authors: Wei
authors: Xinhong
authors: X
authors: Qian
authors: Delin
authors: D
authors: Lei
authors: Qin
authors: Q
authors: Ma
authors: Yanpu
authors: Y
authors: Liu
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D002470:Cell Survival / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000235:genetics / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000235:genetics / Q000378:metabolism*; D009361:Neoplasm Invasiveness / Q000235:genetics; D034622:RNA Interference; D051881:Receptor, Notch1 / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D014062:Tongue Neoplasms / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*
chemical_list: D051881:Receptor, Notch1; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9