title: A case of drug-induced hypersensitivity syndrome due to carbamazepine.
abstract: The patient was a 51-year-old man who had been prescribed carbamazepine for right third-branch trigeminal neuralgia. He had stopped taking the medication after the neuralgia resolved. When the neuralgia recurred, he resumed medication, and about 1 month later he developed fever, fatigue, cervical lymphadenopathy, generalized skin flushing, facial edema and perioral vesicles, and was admitted to Ichikawa General Hospital, Tokyo Dental College. Oral findings showed reddening and erosion of the buccal mucosa. Routine laboratory examination revealed leukocytosis and hepatic dysfunction. Human herpesvirus 6 antibody titer remarkably increased during development of eruptions. These findings led to a diagnosis of drug-induced hypersensitivity syndrome. Carbamazepine was discontinued, and prednisolone (30 mg/day) was started and tapered based on improvement of symptoms. Because skin symptoms recurred after he was discharged 15 days after admission, the dose of prednisolone was increased and the symptoms finally disappeared. The patient has experienced no further recurrence.
authors: Department of Oral Medicine, Oral and Maxillofacial Surgery, Tokyo Dental College, Japan.
authors: Mitsuaki
authors: M
authors: Morimoto
authors: Yutaka
authors: Y
authors: Watanabe
authors: Takehiro
authors: T
authors: Arisaka
authors: Atsushi
authors: A
authors: Takada
authors: Morio
authors: M
authors: Tonogi
authors: Gen-yuki
authors: GY
authors: Yamane
authors: Daihei
authors: D
authors: Fukushima
authors: Shin-ichi
authors: S
authors: Takahashi
authors: Yoichi
authors: Y
authors: Tanaka
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D002220:Carbamazepine / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D003875:Drug Eruptions / Q000209:etiology; D004342:Drug Hypersensitivity / Q000209:etiology*; D005148:Facial Dermatoses / Q000139:chemically induced; D015654:Herpesvirus 6, Human / Q000187:drug effects; D006801:Humans; D007964:Leukocytosis / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000139:chemically induced; D019349:Roseolovirus Infections / Q000175:diagnosis; D013577:Syndrome; D014277:Trigeminal Neuralgia / Q000188:drug therapy; D014775:Virus Activation / Q000187:drug effects
chemical_list: D018712:Analgesics, Non-Narcotic; D002220:Carbamazepine