title: Facile synthesis of new 4-aza-podophyllotoxin analogs via microwave-assisted multi-component reactions and evaluation of their cytotoxic activity.
abstract: A series of new 4-aza-podophyllotoxin analogs containing thiazole unit were synthesized via multi-component reactions of aldehydes, tetronic acid and 2-methylbenzo[d]thiazol-5-amine under microwave irradiation. The method not only provides a valuable tool in design and synthesis of new 4-aza-podophyllotoxin analogs but also has the advantages of atom-economy, environmental-friendliness, good yields and operational simplicity. More importantly, the preliminary evaluation on the cytotoxic activity of this type of new 4-aza-podophyllotoxin analogs has resulted in the finding of several compounds with potent and efficacious cytotoxicity to three carcinoma cell lines M14, MCF7 and SW1116.
authors: School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, PR China.
authors: Feng
authors: F
authors: Shi
authors: Xiao-Ning
authors: XN
authors: Zeng
authors: Ge
authors: G
authors: Zhang
authors: Ning
authors: N
authors: Ma
authors: Bo
authors: B
authors: Jiang
authors: Shujiang
authors: S
authors: Tu
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001372:Aza Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D015195:Drug Design; D006801:Humans; D020128:Inhibitory Concentration 50; D008872:Microwaves; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D011034:Podophyllotoxin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D001372:Aza Compounds; D011034:Podophyllotoxin