title: The association of body composition and sex hormones with quantitative ultrasound parameters at the calcaneus and phalanxes in elderly women.
abstract: We investigated the associations of body composition and sex hormones with quantitative ultrasound (QUS) parameters carried out at different skeletal sites. In 897 postmenopausal women (64.1 ± 6.6 years) we measured QUS at the calcaneus (stiffness) by Achilles-GE and at phalanxes (amplitude-dependent speed of sound [AD-SOS], bone transmission time [BTT], and ultrasound bone profile index [UBPI]) by Bone Profiler-IGEA. In all subjects we measured fat mass (FM), lean mass (LM), android fat, and gynoid fat by DXA. In all subjects we also assessed serum testosterone (T), estradiol (E(2)), sex-hormone binding globulin, free estrogen index (FEI), free androgen index, 25-hydroxyvitamin D (25OHD), bone alkaline phosphatase (B-ALP), and type I collagen β carboxy telopeptide. Both E(2) and FEI showed weak but significant correlations with stiffness and QUS parameters at phalanxes. No significant relationships were found between T and QUS. BMI and LM were positively correlated with stiffness (r = 0.14 and r = 0.17, respectively), whereas BMI and FM showed negative correlations with AD-SOS, BTT, and UBPI. 25OHD showed positive relationships with stiffness and QUS at phalanxes. In multivariate models LM and age were associated with stiffness whereas E(2) and age were significant predictors of BTT. AD-SOS was negatively associated with FM, B-ALP, and age but positively with E(2) and 25OHD. In postmenopausal women QUS parameters at the calcaneus and at phalanxes are significantly, but diversely, associated with body composition, sex hormones, 25OHD, and bone turnover markers.
authors: Department of Internal Medicine, Endocrine-Metabolic Science and Biochemistry, University of Siena, Policlinico Le Scotte, Italy. gonnelli@unisi.it
authors: S
authors: S
authors: Gonnelli
authors: C
authors: C
authors: Caffarelli
authors: L
authors: L
authors: Tanzilli
authors: D
authors: D
authors: Merlotti
authors: L
authors: L
authors: Gennari
authors: S
authors: S
authors: Rossi
authors: B
authors: B
authors: Lucani
authors: M S
authors: MS
authors: Campagna
authors: B
authors: B
authors: Franci
authors: R
authors: R
authors: Nuti
mesh_terms: D000368:Aged; D001823:Body Composition; D001851:Bone Diseases, Metabolic / Q000175:diagnosis / Q000000981:diagnostic imaging; D002111:Calcaneus / Q000000981:diagnostic imaging*; D003430:Cross-Sectional Studies; D004958:Estradiol / Q000097:blood; D005260:Female; D050278:Finger Phalanges / Q000000981:diagnostic imaging*; D012739:Gonadal Steroid Hormones / Q000097:blood* / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause / Q000378:metabolism; D013739:Testosterone / Q000097:blood; D014463:Ultrasonography; D014807:Vitamin D / Q000031:analogs & derivatives / Q000378:metabolism
chemical_list: D012739:Gonadal Steroid Hormones; D014807:Vitamin D; D013739:Testosterone; D004958:Estradiol; C104450:25-hydroxyvitamin D