title: Apparent dexmedetomidine-induced polyuric syndrome in an achondroplastic patient undergoing posterior spinal fusion.
abstract: A 40-year-old achondroplastic patient underwent posterior spinal fusion under general endotracheal anesthesia. Anesthesia was maintained with isoflurane, and sufentanil, dexmedetomidine, and lidocaine infusions. Urine output increased from 150 mL/hr to 950 mL/hr the fourth hour. An increasing serum sodium, low urine-specific gravity, and increased serum osmolarity occurred simultaneously with the polyuria. Within 2 hours of discontinuing the dexmedetomidine infusion urine output greatly decreased. Within 24 hours all signs of the polyuric syndrome resolved spontaneously. Alpha(2) agonists block arginine-vasopressin release and action; however, a polyuric syndrome has not been reported in the human literature.
authors: Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232-7237, USA. allison.greening@gmail.com
authors: Allison
authors: A
authors: Greening
authors: Letha
authors: L
authors: Mathews
authors: James
authors: J
authors: Blair
mesh_terms: D000130:Achondroplasia / Q000188:drug therapy / Q000601:surgery*; D000328:Adult; D020927:Dexmedetomidine / Q000009:adverse effects*; D006801:Humans; D008297:Male; D011141:Polyuria / Q000139:chemically induced* / Q000175:diagnosis*; D013123:Spinal Fusion / Q000009:adverse effects; D013577:Syndrome
chemical_list: D020927:Dexmedetomidine