title: Ivy/neurogliaform interneurons coordinate activity in the neurogenic niche.
abstract: Depolarization by the neurotransmitter GABA regulates adult neurogenesis. We found interneurons of the neurogliaform cell family to be a primary source of GABA for newborn neurons in mouse dentate gyrus. GABAergic depolarization occurred in concert with reduced synaptic inhibition of mature neurons, suggesting that the local circuitry coordinates the activation of new and pre-existing cells.
authors: Department of Neurobiology, McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama, USA.
authors: Sean J
authors: SJ
authors: Markwardt
authors: Cristina V
authors: CV
authors: Dieni
authors: Jacques I
authors: JI
authors: Wadiche
authors: Linda
authors: L
authors: Overstreet-Wadiche
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000235:genetics; D000818:Animals; D000831:Animals, Newborn; D001426:Bacterial Proteins / Q000235:genetics; D055592:Biophysical Phenomena / Q000187:drug effects / Q000235:genetics; D015816:Cell Adhesion Molecules, Neuronal / Q000378:metabolism; D004558:Electric Stimulation / Q000379:methods; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D018756:GABA Antagonists / Q000494:pharmacology; D018698:Glutamic Acid / Q000494:pharmacology; D049452:Green Fluorescent Proteins / Q000235:genetics; D007395:Interneurons / Q000187:drug effects / Q000502:physiology*; D007478:Iontophoresis / Q000379:methods; D008164:Luminescent Proteins / Q000235:genetics; D008239:Lysine / Q000031:analogs & derivatives / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D008959:Models, Neurological; D009415:Nerve Net / Q000187:drug effects / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009433:Neural Inhibition / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D055495:Neurogenesis / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D009478:Neuropeptide Y / Q000235:genetics / Q000378:metabolism; D052248:Nitric Oxide Synthase Type I / Q000378:metabolism; D018408:Patch-Clamp Techniques; D010852:Picrotoxin / Q000494:pharmacology; D011333:Pro-Opiomelanocortin / Q000235:genetics / Q000378:metabolism; D011810:Quinoxalines / Q000494:pharmacology; D000091042:Reelin Protein; D012697:Serine Endopeptidases / Q000378:metabolism; D055153:Stem Cell Niche / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D055366:Synaptic Potentials / Q000187:drug effects / Q000235:genetics; D013997:Time Factors; D014633:Valine / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D001426:Bacterial Proteins; D015816:Cell Adhesion Molecules, Neuronal; D018691:Excitatory Amino Acid Antagonists; D016326:Extracellular Matrix Proteins; D018756:GABA Antagonists; D018698:Glutamic Acid; D049452:Green Fluorescent Proteins; D008164:Luminescent Proteins; D008239:Lysine; D009419:Nerve Tissue Proteins; D009478:Neuropeptide Y; D052248:Nitric Oxide Synthase Type I; D010852:Picrotoxin; D011333:Pro-Opiomelanocortin; D011810:Quinoxalines; D000091042:Reelin Protein; D012697:Serine Endopeptidases; D014633:Valine; C485184:enhanced green fluorescent protein; C054562:yellow fluorescent protein, Bacteria; C062865:2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline; C056639:2-amino-5-phosphopentanoic acid; C013411:biocytin