title: Additive value of adult bone-marrow-derived cell transplantation to conventional revascularization in chronic ischemic heart disease: a systemic review and meta-analysis.
abstract: OBJECTIVE
  Whether adult bone marrow (BM)-derived cells (BMCs) transplantation benefits patients with chronic ischemic heart disease (IHD) remains controversial. This systemic and meta-analysis study aimed to assess the potential therapeutic effects of BMCs transplantation with revascularization in chronic IHD.
  
  
  METHODS
  Randomized controlled trials of BMCs in combination with coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) for chronic IHD were identified by searching Medline, Embase, the Cochrane Controlled Trials Register, the Cochrane Library, and the Web of Science. We conducted a random-effects meta-analysis across eligible studies measuring the same outcomes.
  
  
  RESULTS
  Ten randomized controlled trials including 422 participants were reviewed. In the trials with six months of follow-up, BMCs transplantation improved left ventricular (LV) ejection fraction (LVEF) by 4.02% and reduced LV end-systolic and end-diastolic volumes. Subgroup analysis revealed a statistically significant difference in LVEF associated with primary intervention, route of cell delivery, cell type, and baseline LVEF, but not with cell dose or storage duration.
  
  
  CONCLUSIONS
  Selected-BMCs transplantation through myocardial injection after surgical revascularization may benefit patients with chronic IHD and severely impaired LV function. Due to the limitation of patient number, RCT with larger sample size and long follow-up are required for future research.
authors: Shanghai Jiaotong University, Ruijin Hospital, Department of Cardiac Surgery, Shanghai 200025, PR China. zq11607@rjh.com.cn
authors: Qiang
authors: Q
authors: Zhao
authors: Xiaofeng
authors: X
authors: Ye
mesh_terms: D000328:Adult; D015906:Angioplasty, Balloon, Coronary; D016009:Chi-Square Distribution; D002908:Chronic Disease; D003131:Combined Modality Therapy; D001026:Coronary Artery Bypass; D019317:Evidence-Based Medicine; D006801:Humans; D017202:Myocardial Ischemia / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic; D020127:Recovery of Function; D033581:Stem Cell Transplantation; D013318:Stroke Volume; D013997:Time Factors; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D016277:Ventricular Function, Left