title: Cross-validation of MR elastography and ultrasound transient elastography in liver stiffness measurement: discrepancy in the results of cirrhotic liver.
abstract: OBJECTIVE
  To evaluate individual differences in liver stiffness measurement using both MR elastography (MRE) and ultrasound transient elastography (UTE) in patients with chronic liver disease.
  
  
  METHODS
  This study included 80 patients with chronic liver disease who underwent both UTE and MRE. MRE and UTE were performed using a pneumatic driver (60 Hz) and an ultrasound probe with a vibrator (50 Hz), respectively. Liver stiffness data measured using the two techniques (μ(UTE) and μ(MRE) ) were compared with respect to shear modulus. The patients were subdivided into four quartiles on the basis of average of the μ(UTE) and μ(MRE) values for each patient.
  
  
  RESULTS
  The analysis of the 4 quartile groups revealed that μ(UTE) was significantly higher than μ(MRE) in the two most stiff liver groups: μ(UTE) versus μ(MRE) , 7.5 (1.2) versus 6.0 (0.72) kPa for the group with [μ(UTE) + μ(MRE) ]/2 of 5.6-8.0 kPa; 15.1(4.2) versus 6.7 (1.4) kPa for the group with >8.0 kPa. However, in the least stiff liver group (i.e., the group with [μ(UTE) + μ(MRE) ]/2 < 3.2 kPa), μ(UTE) was significantly lower than μ(MRE) .
  
  
  CONCLUSIONS
  The shear modulus measured by UTE and MRE are not equivalent, especially in patients with stiff livers.
authors: Department of Radiology, University of Yamanashi, Yamanashi, Japan. utaroh-motosugi@nifty.com
authors: Utaroh
authors: U
authors: Motosugi
authors: Tomoaki
authors: T
authors: Ichikawa
authors: Fumitake
authors: F
authors: Amemiya
authors: Hironobu
authors: H
authors: Sou
authors: Katsuhiro
authors: K
authors: Sano
authors: Ali
authors: A
authors: Muhi
authors: Nobuyuki
authors: N
authors: Enomoto
authors: Tsutomu
authors: T
authors: Araki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002908:Chronic Disease; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D016012:Poisson Distribution; D012372:ROC Curve; D012189:Retrospective Studies