title: Localized surface plasmon resonance: nanostructures, bioassays and biosensing--a review.
abstract: Localized surface plasmon resonance (LSPR) is an optical phenomena generated by light when it interacts with conductive nanoparticles (NPs) that are smaller than the incident wavelength. As in surface plasmon resonance, the electric field of incident light can be deposited to collectively excite electrons of a conduction band, with the result being coherent localized plasmon oscillations with a resonant frequency that strongly depends on the composition, size, geometry, dielectric environment and separation distance of NPs. This review serves to describe the physical theory of LSPR formation at the surface of nanostructures, and the potential for this optical technology to serve as a basis for the development bioassays and biosensing of high sensitivity. The benefits and challenges associated with various experimental designs of nanoparticles and detection systems, as well as creative approaches that have been developed to improve sensitivity and limits of detection are highlighted using examples from the literature.
authors: Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada.
authors: Eleonora
authors: E
authors: Petryayeva
authors: Ulrich J
authors: UJ
authors: Krull
mesh_terms: D015374:Biosensing Techniques; D004247:DNA / Q000032:analysis; D049329:Nanostructures / Q000737:chemistry*; D009693:Nucleic Acid Hybridization; D011506:Proteins / Q000032:analysis; D013059:Spectrum Analysis, Raman; D020349:Surface Plasmon Resonance; D013499:Surface Properties
chemical_list: D011506:Proteins; D004247:DNA