title: First insights into the genetic diversity of Mycobacterium tuberculosis strains in Salvador, Bahia State, Brazil.
abstract: This study constitutes a first attempt to describe the genetic population structure of Mycobacterium tuberculosis circulating in Salvador, Bahia State, Brazil. A total of 56 confirmed cases of pulmonary tuberculosis, identified between March and June 2008, were analyzed using restriction fragment length polymorphism (IS6110-RFLP). The study population was characterized by a predominance of males (71.43%) over 30 years of age (68.75%). Forty-one isolates were found to belong to a single pattern (73.2%), while 15 (26.7%) were found in group patterns, forming six clusters. The higher level of diversity observed is much more suggestive of endogenous reactivation than recent transmission.
authors: Centro de Pesquisa Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brasil. aida@aluno.bahia.fiocruz.br
authors: Aída Cristina do Nascimento
authors: AC
authors: Silva
authors: Lucilaine
authors: L
authors: Ferrazoli
authors: Vera
authors: V
authors: Simonsen
authors: Joice Neves
authors: JN
authors: Reis
authors: Susan Martins
authors: SM
authors: Pereira
authors: Theomira Mauadie de Azevedo
authors: TM
authors: Carmo
authors: Eduardo Luiz Andrade
authors: EL
authors: Mota
authors: Mitermayer Galvão
authors: MG
authors: Reis
mesh_terms: D000328:Adult; D017677:Age Distribution; D001938:Brazil; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D009169:Mycobacterium tuberculosis / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D017678:Sex Distribution; D014397:Tuberculosis, Pulmonary / Q000235:genetics / Q000382:microbiology*; D055815:Young Adult