title: 1-Hexyl n-cyanoacrylate compound (Neucrylate™ AN), a new berry aneurysm treatment. I. Theoretical basis and laboratory evaluation.
abstract: OBJECTIVE
  To develop and optimize a system for treating cerebral berry aneurysm using a new polymer based liquid embolic agent.
  
  
  METHODS
  Using a variety of human corrosion casting aneurysm replicas placed in a circuit of pulsatile flowing blood, techniques were developed to optimize aneurysm filling and recreate good blood flow dynamics. As part of this effort, both experienced physicians and lay personnel were asked to treat these replicas to discover common failure modes. Additional surgically created aneurysms in dog carotid arteries were treated by experienced physicians.
  
  
  RESULTS
  Physicians experienced in the use of microcatheters and endovascular techniques learned to use the device effectively after, on average, five aneurysm treatments. In the dog aneurysms, all were treated to complete filling.
authors: Department of Radiology, UCSD Medical Center, San Diego, California 92103-8756, USA. cwkerber@gmail.com
authors: Charles W
authors: CW
authors: Kerber
authors: Ramin Sean
authors: RS
authors: Pakbaz
mesh_terms: D000818:Animals; D002404:Catheterization / Q000379:methods* / Q000592:standards; D019411:Clinical Laboratory Techniques / Q000379:methods / Q000592:standards; D016319:Corrosion Casting / Q000379:methods* / Q000592:standards; D003487:Cyanoacrylates / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004285:Dogs; D006801:Humans; D002532:Intracranial Aneurysm / Q000145:classification / Q000473:pathology / Q000601:surgery*; D012756:Sheep; D013552:Swine; D014014:Tissue Adhesives / Q000008:administration & dosage*
chemical_list: D003487:Cyanoacrylates; D014014:Tissue Adhesives