title: A survey on hematology-oncology pediatric AIEOP centers: prophylaxis, empirical therapy and nursing prevention procedures of infectious complications.
abstract: A nationwide questionnaire-based survey was designed to evaluate the management and prophylaxis of febrile neutropenia in pediatric patients admitted to hematology-oncology and hematopoietic stem cell transplant units. Of the 34 participating centers, 40 and 63%, respectively, continue to prescribe antibacterial and antimycotic prophylaxis in low-risk subjects and 78 and 94% in transplant patients. Approximately half of the centers prescribe a combination antibiotic regimen as first-line therapy in low-risk patients and up to 81% in high-risk patients. When initial empirical therapy fails after seven days, 63% of the centers add empirical antimycotic therapy in low-and 81% in high-risk patients. Overall management varies significantly across centers. Preventive nursing procedures are in accordance with international guidelines. This survey is the first to focus on prescribing practices in children with cancer and could help to implement practice guidelines.
authors: Immunoinfectivology Units, IRCCS Children's Hospital Bambino Gesù, Rome, Italy. susanna.livadiotti@opbg.net
authors: Susanna
authors: S
authors: Livadiotti
authors: Giuseppe Maria
authors: GM
authors: Milano
authors: Annalisa
authors: A
authors: Serra
authors: Laura
authors: L
authors: Folgori
authors: Alessandro
authors: A
authors: Jenkner
authors: Elio
authors: E
authors: Castagnola
authors: Simone
authors: S
authors: Cesaro
authors: Mario R
authors: MR
authors: Rossi
authors: Angelica
authors: A
authors: Barone
authors: Giulio
authors: G
authors: Zanazzo
authors: Francesca
authors: F
authors: Nesi
authors: Maria
authors: M
authors: Licciardello
authors: Raffaella
authors: R
authors: De Santis
authors: Ottavio
authors: O
authors: Ziino
authors: Monica
authors: M
authors: Cellini
authors: Fulvio
authors: F
authors: Porta
authors: Desiree
authors: D
authors: Caselli
authors: Giuseppe
authors: G
authors: Pontrelli
mesh_terms: D000890:Anti-Infective Agents / Q000009:adverse effects / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis; D002648:Child; D003140:Communicable Disease Control; D003141:Communicable Diseases / Q000188:drug therapy / Q000209:etiology / Q000451:nursing; D019337:Hematologic Neoplasms / Q000150:complications* / Q000451:nursing / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D011795:Surveys and Questionnaires
chemical_list: D000890:Anti-Infective Agents