title: On becoming a T cell, a convergence of factors kick it up a Notch along the way.
abstract: The thymus is seeded by bone marrow-derived progenitors, which undergo a series of differentiation and proliferation events in order to generate functional T lymphocytes. The Notch signaling pathway, together with multiple transcription factors, act in concert to commit progenitors to a T-lineage fate, extinguishing non-T cell potential, inducing thymocyte differentiation and supporting proliferation and survival along the way to becoming a mature T cell. This review focuses on recent evidence regarding the complex interplay between the Notch pathway and other key transcription factors at specific lineage-decision points during the program of T cell development.
authors: Department of Immunology, University of Toronto, Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada.
authors: Patrycja K
authors: PK
authors: Thompson
authors: Juan Carlos
authors: JC
authors: Zúñiga-Pflücker
mesh_terms: D002454:Cell Differentiation; D019070:Cell Lineage; D006801:Humans; D008954:Models, Biological; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000166:cytology* / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D051880:Receptors, Notch; D014157:Transcription Factors