title: The effect of paracetamol on postoperative nausea and vomiting during the first 24 h after strabismus surgery: a prospective, randomised, double-blind study.
abstract: BACKGROUND
  Strabismus surgery is one of the most common ophthalmic surgical procedures in children and is associated with significant postoperative nausea and vomiting (PONV).
  
  
  OBJECTIVE
  We evaluated the effect of intravenous paracetamol on PONV in children after strabismus surgery.
  
  
  METHODS
  Prospective, placebo-controlled, randomised double-blind study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Ninety children, between 2 and 14 years scheduled for strabismus surgery, were recruited. Eighty-six completed the study.
  
  
  METHODS
  After induction of anaesthesia, intravenous dexamethasone 0.1 mg kg was administered to all. The patients were enrolled to receive either intravenous physiological saline (group S) or paracetamol 15 mg kg (group P).
  
  
  METHODS
  Incidence of PONV in the first 24 h postoperatively.
  
  
  RESULTS
  General and clinical characteristics of the children were similar in both groups. PONV during the first 24 h was significantly higher in group S in comparison with group P (group S vs. group P, 33 vs. 14.6%, respectively, P = 0.038 for nausea; 24.4 vs. 7.3%, respectively, P = 0.030 for vomiting). The number of analgesic administrations during the first 24 h was higher in group S compared with group P (1.31 ± 0.85 and 0.73 ± 0.6, respectively, P = 0.001). The repeat number of postoperative analgesic administrations was significantly different between groups during the first 24 h (P = 0.005), but during 24-48 h was not significant.
  
  
  CONCLUSIONS
  Intraoperative administration of intravenous paracetamol decreases the incidence of PONV during the first 24 h in children after strabismus surgery.
authors: Department of Anaesthesiology and Reanimation, Baskent University, Ankara, Turkey. oyacok@yahoo.com
authors: Oya Y
authors: OY
authors: Cok
authors: H Evren
authors: HE
authors: Eker
authors: Aysel
authors: A
authors: Pelit
authors: Silay
authors: S
authors: Canturk
authors: Sule
authors: S
authors: Akin
authors: Anis
authors: A
authors: Aribogan
authors: Gulnaz
authors: G
authors: Arslan
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage*; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007430:Intraoperative Care / Q000379:methods; D008297:Male; D010147:Pain Measurement / Q000187:drug effects / Q000379:methods; D020250:Postoperative Nausea and Vomiting / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D011446:Prospective Studies; D013285:Strabismus / Q000503:physiopathology / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000082:Acetaminophen