title: Involvement of kainate receptors in the analgesic but not hypnotic effects induced by inhalation anesthetics.
abstract: In the present study, the role of kainate (KA) receptors in hypnosis and analgesia induced by emulsified inhalation anesthetics was investigated. A mouse model of hypnosis and analgesia was established by an intraperitoneal injection of emulsified enflurane, isoflurane or sevoflurane. We intracerebroventricularly (icv) or intrathecally (it) administered KA, a KA receptor agonist to mice. The effects of the KA on the sleep time were observed using a hypnosis test, and the tail-withdrawal latency was analyzed using the tail-withdrawal test. In the hypnosis test, KA (2.5, 5 or 10 ng; icv administered) treatment had no distinctive effects on the sleep time of mice treated with emulsified inhalation anesthetics. In the tail-withdrawal test, KA (0.2, 0.4 or 0.8 ng; it administered) treatment significantly and dose-dependently decreased the tail-withdrawal latency of mice treated with emulsified anesthetics. These results suggested that KA receptors may modulate the analgesic but not hypnotic effects induced by emulsified enflurane, isoflurane or sevoflurane.
authors: Department of Anesthesiology, the Affiliated People's Hospital of Jiangsu University and the First People's Hospital of Zhenjiang, Zhenjiang, Jiangsu, 212002, PR China. hanglihua@yahoo.com.cn
authors: Li-Hua
authors: LH
authors: Hang
authors: Dong-Hua
authors: DH
authors: Shao
authors: Yue-Ping
authors: YP
authors: Gu
authors: Ti-Jun
authors: TJ
authors: Dai
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004655:Emulsions; D004737:Enflurane / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D006991:Hypnosis, Anesthetic / Q000379:methods; D007276:Injections, Intraventricular; D007278:Injections, Spinal; D007530:Isoflurane / Q000008:administration & dosage / Q000494:pharmacology; D007608:Kainic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage / Q000494:pharmacology; D051379:Mice; D018092:Kainic Acid Receptors / Q000187:drug effects* / Q000378:metabolism; D000077149:Sevoflurane; D012890:Sleep / Q000187:drug effects
chemical_list: D000700:Analgesics; D018685:Anesthetics, Inhalation; D004655:Emulsions; D004737:Enflurane; D007530:Isoflurane; D007608:Kainic Acid; D008738:Methyl Ethers; D018092:Kainic Acid Receptors; D000077149:Sevoflurane