title: Death receptor signalling in central nervous system inflammation and demyelination.
abstract: Death receptors (DRs) are members of the tumor necrosis factor receptor (TNF-R) superfamily that are characterised by the presence of a conserved intracellular death domain and are able to trigger a signalling pathway leading to apoptosis. Strong evidence suggests that DRs contribute to the pathology of tissue destructive diseases, including multiple sclerosis (MS), the most common inflammatory demyelinating disease of the central nervous system (CNS). Here, we review the evidence supporting a role for DRs in MS pathology and its implications for the development of therapeutic strategies for MS and other demyelinating pathologies of the CNS.
authors: Department for Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, VIB, B-9052 Ghent, Belgium.
authors: Conor
authors: C
authors: Mc Guire
authors: Rudi
authors: R
authors: Beyaert
authors: Geert
authors: G
authors: van Loo
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000276:immunology; D002490:Central Nervous System / Q000254:growth & development / Q000276:immunology* / Q000473:pathology*; D003711:Demyelinating Diseases; D004195:Disease Models, Animal; D053222:Fas Ligand Protein / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D009103:Multiple Sclerosis / Q000276:immunology / Q000473:pathology; D020800:Receptor, Nerve Growth Factor / Q000276:immunology; D053218:Receptors, Death Domain / Q000378:metabolism*; D018124:Receptors, Tumor Necrosis Factor / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology; D019014:fas Receptor / Q000276:immunology
chemical_list: D053222:Fas Ligand Protein; D020800:Receptor, Nerve Growth Factor; D053218:Receptors, Death Domain; D018124:Receptors, Tumor Necrosis Factor; D053221:TNF-Related Apoptosis-Inducing Ligand; D014409:Tumor Necrosis Factor-alpha; D019014:fas Receptor