title: Human neutrophil peptide in lung chronic allograft dysfunction.
abstract: BACKGROUND
  Our previous case-control study identified human neutrophil peptide (HNP) as a potential biomarker for bronchiolitis obliterans syndrome (BOS) in lung transplant recipients.
  
  
  OBJECTIVE
  To prospectively validate HNP as a biomarker for BOS.
  
  
  METHODS
  HNP was measured by ELISA in bronchoalveolar lavage (BAL) fluid in lung transplant recipients.
  
  
  RESULTS
  The first HNP measurement after reaching baseline pulmonary function was predictive of developing BOS ≥2 (p = 0.0419). HNP remained elevated in those that developed BOS. The effect of potential confounders did not significantly impact BOS-free survival time.
  
  
  CONCLUSIONS
  HNP levels are elevated early and persistently in those that develop BOS.
authors: Department of Biostatistics, University of Minnesota, Minneapolis, MN, USA.
authors: Cavan
authors: C
authors: Reilly
authors: Tereza
authors: T
authors: Cervenka
authors: Marshall I
authors: MI
authors: Hertz
authors: Trisha
authors: T
authors: Becker
authors: Chris H
authors: CH
authors: Wendt
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D001992:Bronchoalveolar Lavage Fluid; D004797:Enzyme-Linked Immunosorbent Assay; D006084:Graft Rejection; D006801:Humans; D016040:Lung Transplantation; D009504:Neutrophils / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism*; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D010455:Peptides