title: ICESp2905, the erm(TR)-tet(O) element of Streptococcus pyogenes, is formed by two independent integrative and conjugative elements.
abstract: In ICESp2905, a widespread erm(TR)- and tet(O)-carrying genetic element of Streptococcus pyogenes, the two resistance determinants are contained in separate fragments inserted into a scaffold of clostridial origin. ICESp2905 (∼65.6 kb) was transferable not only in its regular form but also in a defective form lacking the erm(TR) fragment (ICESp2906, ∼53.0 kb). The erm(TR) fragment was also an independent integrative and conjugative element (ICE) (ICESp2907, ∼12.6 kb). ICESp2905 thus results from one ICE (ICESp2907) being integrated into another (ICESp2906).
authors: Department of Biomedical Sciences, Section of Microbiology, Marche Polytechnic University, Ancona, Italy.
authors: Eleonora
authors: E
authors: Giovanetti
authors: Andrea
authors: A
authors: Brenciani
authors: Erika
authors: E
authors: Tiberi
authors: Alessandro
authors: A
authors: Bacciaglia
authors: Pietro Emanuele
authors: PE
authors: Varaldo
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001483:Base Sequence; D002874:Chromosome Mapping; D002876:Chromosomes, Bacterial; D003227:Conjugation, Genetic; D004269:DNA, Bacterial; D004270:DNA, Circular; D004917:Erythromycin / Q000008:administration & dosage*; D005798:Genes, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D017422:Sequence Analysis, DNA; D013290:Streptococcal Infections / Q000188:drug therapy* / Q000382:microbiology / Q000635:transmission; D013297:Streptococcus pyogenes / Q000187:drug effects / Q000235:genetics* / Q000472:pathogenicity; D013752:Tetracycline / Q000008:administration & dosage*; D013753:Tetracycline Resistance
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D004270:DNA, Circular; D004917:Erythromycin; D013752:Tetracycline