title: Does 6% hydroxyethyl starch 130/0.4 impact differently on blood glucose than 4% gelatin in patients receiving open heart surgery?
abstract: OBJECTIVE
  To investigate whether starch-based colloid may impact differently on blood glucose than a gelatin-based colloid in adult patients receiving open heart surgery.
  
  
  METHODS
  70 adult patients scheduled for elective first-time cardiac surgery were enrolled and randomized into two groups. The circuits were primed with either 6% HES 130/0.4 or 4% gelatin. The peak glucose level, incidence of hyperglycemia, glucose variation and glucose level at different time points during operation were compared between the two groups. A p-value ≤ 0.05 was accepted as significant.
  
  
  RESULTS
  The peak glucose (150±30mg/dl vs 142±27, p=0.236) and glucose variation demonstrated by standard deviation (26±12mg/dl vs 23±11mg/dl, p=0.202) were comparable between the two groups. Repeated measurement ANOVA revealed that the main effect for artificial colloid was not significant (p=0.349).
  
  
  CONCLUSIONS
  With the data available, we could not prove that starch-based colloid (HES130) had a different impact on intra-operative blood glucose than a gelatin-based colloid in adult patients receiving open heart surgery.
authors: Department of Cardiopulmonary Bypass, FuWai Hospital, Beijing, China. lousongfw@gmail.com
authors: S
authors: S
authors: Lou
authors: L
authors: L
authors: Bian
authors: C
authors: C
authors: Long
authors: Z
authors: Z
authors: Wang
authors: J
authors: J
authors: Ma
authors: B
authors: B
authors: Zhou
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001786:Blood Glucose / Q000378:metabolism*; D002315:Cardiopulmonary Bypass; D005260:Female; D005780:Gelatin / Q000627:therapeutic use*; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010952:Plasma Substitutes / Q000627:therapeutic use*; D013903:Thoracic Surgery
chemical_list: D001786:Blood Glucose; C485123:HES 130-0.4; D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes; D005780:Gelatin