title: Analysis of systemic inflammatory response in the carcinogenic process of uterine cervical neoplasia.
abstract: The inflammatory response is an active process in cervical cancer and may act in the progression and/or regression of the lesion. At the site of inflammation, macrophages and neutrophils are present as well as cytokines such as TNF-α and IFN-γ. This study aims to evaluate the inflammatory response levels in women with cervical intraepithelial lesions (CIN) and with squamous cell carcinoma (SCC) of the cervix. Serum samples obtained from women without evidence of disease (n=30), with CIN (n=30) and with SCC of the cervix (n=30) were analyzed for the activities of N-acetylglucosaminidase (NAG) and myeloperoxidase (MPO) by enzymatic assay and the serum levels of TNF-α and IFN-γ by ELISA assay. The activities of NAG and MPO and the level of TNF-α were higher in women with CIN compared to the women with SCC. The levels of IFN-γ were lower in the group of women with CIN compared to the group with SCC. There was not a significant association between the degree of the CIN and the staging of the SCC of the cervix and the degree of inflammation as assessed by the levels of inflammatory markers. The inflammatory response was inversely correlated with the progression of the carcinogenic process. In the three groups, the control group, women with CIN and women with invasive SCC, there was no association between the degree of preinvasive lesions and staging of the SCC of the cervix.
authors: Department of Gynecology and Obstetrics, Botucatu Medical School, UNESP, Univ Estadual Paulista, Botucatu, SP, Brazil.
authors: Elisa Lopes e
authors: EL
authors: Lages
authors: Andrezza Vilaça
authors: AV
authors: Belo
authors: Silvia Passos
authors: SP
authors: Andrade
authors: Monaliza Ângela
authors: MÂ
authors: Rocha
authors: Gustavo Ferreira
authors: GF
authors: de Freitas
authors: Rívia Mara
authors: RM
authors: Lamaita
authors: Paulo
authors: P
authors: Traiman
authors: Agnaldo Lopes
authors: AL
authors: Silva-Filho
mesh_terms: D000118:Acetylglucosaminidase / Q000097:blood*; D000328:Adult; D000368:Aged; D015415:Biomarkers; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000503:physiopathology*; D002471:Cell Transformation, Neoplastic; D018450:Disease Progression; D005260:Female; D006801:Humans; D007157:Immunologic Surveillance; D007249:Inflammation / Q000097:blood / Q000503:physiopathology*; D007371:Interferon-gamma / Q000097:blood; D008262:Macrophage Activation; D008264:Macrophages / Q000201:enzymology*; D008875:Middle Aged; D009504:Neutrophils / Q000201:enzymology*; D009195:Peroxidase / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis; D002583:Uterine Cervical Neoplasms / Q000097:blood / Q000503:physiopathology*; D002578:Uterine Cervical Dysplasia / Q000097:blood / Q000503:physiopathology*
chemical_list: D015415:Biomarkers; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma; D009195:Peroxidase; D000118:Acetylglucosaminidase