title: Performance of the MGIT TBc identification test and meta-analysis of MPT64 assays for identification of the Mycobacterium tuberculosis complex in liquid culture.
abstract: Rapid MPT64-based immunochromatographic tests (MPT64 ICTs) have been developed to detect Mycobacterium tuberculosis complex (MTBC) in culture. We demonstrated the noninferiority of one commercial MTP64 ICT, the MGIT TBc identification (TBcID) test, to GenoType line probe assays for MTBC identification in positive MGIT cultures. Meta-analysis of MPT64 ICT performance for identification of MTBC in liquid culture confirmed similar very high sensitivities and specificities for all three commercial MPT64 assays for which sufficient data were available.
authors: KEMRI-Wellcome Trust Research Programme, P.O. Box 230, 80108 Kilifi, Kenya. dr.a.brent@gmail.com
authors: Andrew J
authors: AJ
authors: Brent
authors: Daisy
authors: D
authors: Mugo
authors: Robert
authors: R
authors: Musyimi
authors: Agnes
authors: A
authors: Mutiso
authors: Susan
authors: S
authors: Morpeth
authors: Michael
authors: M
authors: Levin
authors: J Anthony G
authors: JA
authors: Scott
mesh_terms: D000942:Antigens, Bacterial / Q000032:analysis*; D019411:Clinical Laboratory Techniques / Q000379:methods*; D006801:Humans; D007118:Immunoassay / Q000379:methods; D025202:Molecular Diagnostic Techniques / Q000379:methods; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D012680:Sensitivity and Specificity
chemical_list: D000942:Antigens, Bacterial; C510537:MPT64 protein, Mycobacterium tuberculosis