title: Occurrence of cholelithiasis and cholecystitis in amyotrophic lateral sclerosis patients with long-term tracheostomy invasive ventilation.
abstract: OBJECTIVE
  We clarified the prevalence of cholelithiasis/cholecystitis in long-term tracheostomy invasive ventilation (TIV) patients in our hospital.
  
  
  METHODS
  We investigated the occurrence of cholelithiasis/cholecystitis in twenty-seven TIV patients over the past eight years.
  
  
  RESULTS
  There were ten patients with cholelithiasis/cholecystitis. The underlying disease was amyotrophic lateral sclerosis (ALS), except for 1 patient. Mean age was 56.2 ± 4.7 years and the average period to the attack of cholelithiasis/cholecystitis from TIV was 57.6 ± 15.1 months. Two patients of acute cholecystitis had acalculous cholecystitis. Five of the ten patients developed a severe state of cholecystitis and needed aggressive therapy.
  
  
  CONCLUSIONS
  The prevalence of gallstones, symptom prevalence of asymptomatic cholelithiasis, the percentage of acalculous cholecystitis of acute cholecystitis in TIV patients was higher than in the general population. Therefore, it may be possible that TIV is a risk for cholelithiasis/cholecystitis. Some of the ALS patients with long-term TIV develop severe cholelithiasis/cholecystitis, and those facts should be considered in our daily clinical practice.
authors: Department of Neurology, Kitasato University School of Medicine, Japan. ekitamura@med.kitasato-u.ac.jp
authors: Eiji
authors: E
authors: Kitamura
authors: Mieko
authors: M
authors: Ogino
mesh_terms: D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000150:complications / Q000628:therapy*; D002764:Cholecystitis / Q000453:epidemiology* / Q000209:etiology; D002769:Cholelithiasis / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012121:Respiration, Artificial; D012189:Retrospective Studies; D013997:Time Factors; D014139:Tracheostomy; D055815:Young Adult