title: Successful tigecycline lock therapy in a Lactobacillus rhamnosus catheter-related bloodstream infection.
abstract: BACKGROUND
  Catheter-related bloodstream infections very often involve the premature removal of long-term intravascular devices (LTID). The antibiotic lock therapy (ALT) represents a conservative approach to the treatment of uncomplicated infections of tunneled LTID when catheter removal is not a feasible option.
  
  
  METHODS
  We present here the first reported case of tunneled LTID bloodstream infection due to a multidrug resistant Lactobacillus rhamnosus. The patient, who had large granular lymphocytic leukemia, was successfully treated with systemic tigecycline therapy and lock therapy.
  
  
  CONCLUSIONS
  Our results confirm ALT as a valid catheter-salvage strategy for the treatment of CRBSIs in clinically stable patients when catheter removal is not a feasible option, tigecycline appear to be a good option.
authors: SOD Malattie Infettive e Tropicali, Azienda Ospedaliero-Universitaria Careggi, Largo Brambilla 3, 50134, Florence, Italy. bartalesif@aou-careggi.toscana.it
authors: F
authors: F
authors: Bartalesi
authors: S
authors: S
authors: Veloci
authors: F
authors: F
authors: Baragli
authors: E
authors: E
authors: Mantengoli
authors: S
authors: S
authors: Guidi
authors: A M
authors: AM
authors: Bartolesi
authors: R
authors: R
authors: Mannino
authors: P
authors: P
authors: Pecile
authors: A
authors: A
authors: Bartoloni
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016470:Bacteremia / Q000188:drug therapy*; D055499:Catheter-Related Infections / Q000188:drug therapy* / Q000382:microbiology; D002405:Catheterization, Central Venous / Q000009:adverse effects; D002408:Catheters, Indwelling / Q000382:microbiology; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D052201:Lacticaseibacillus rhamnosus / Q000187:drug effects / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000078304:Tigecycline; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline