title: Synthesis of a platform to access bistramides and their analogues.
abstract: The platform C14-C40, which can be used to prepare bistramide C and 39-oxobistramide K, was synthesized in 19 steps with an overall yield of 6.2%. Furthermore, the chemoselective reduction of the ketone at C-39 was performed giving an easy access to bistramides A, B, D, K, and L. Finally, the versatility of the synthesis of the C14-C40 fragment can allow the preparation of a large variety of stereoisomers to produce bistramide analogues.
authors: Laboratoire de Chimie Organique Associé au CNRS, ESPCI ParisTech, 10, rue Vauquelin, 75231 Paris Cedex 05, France.
authors: Malgorzata
authors: M
authors: Commandeur
authors: Claude
authors: C
authors: Commandeur
authors: Janine
authors: J
authors: Cossy
mesh_terms: D002384:Catalysis; D004988:Ethers, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013141:Spiro Compounds / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D004988:Ethers, Cyclic; D013141:Spiro Compounds