title: Cutaneous effects after prolongaded use of hydroxyurea in Polycythemia Vera.
abstract: Hydroxyurea is an hydroxylated urea derivative used in many myeloproliferative disorders. Many, but unusual cutaneous disorders are related after its prolonged use. Their pathogenesis is not clear, but it is suggested that there is direct toxicity of the drug on the skin. We described a white, 75-year old man with diagnosis of Polycythemia Vera that in 11 years of treatment developed many cutaneous lesions: skin hyperpigmentation, atrophic lesions on forearms, longitudinal melanonychia of 20 nails, right forearm ulcer, cutaneous xerosis, ichthyosis and auricular spinocellular carcinoma. At this moment, the literature reports describe little diversity of lesions in affected patients.
authors: Serviço de Dermatologia, Universidade de Pernambuco, Recife, PE, Brasil.
authors: Emmanuel Rodrigues de
authors: ER
authors: França
authors: Márcia Almeida Galvão
authors: MA
authors: Teixeira
authors: Kleber de Freitas
authors: Kde F
authors: Matias
authors: Daniela Eugenia Costa Morais
authors: DE
authors: Antunes
authors: Rafael de Almeida
authors: Rde A
authors: Braz
authors: Claudia Elise Ferraz
authors: CE
authors: Silva
mesh_terms: D000368:Aged; D000986:Antisickling Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003875:Drug Eruptions / Q000209:etiology*; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D011087:Polycythemia Vera / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D000986:Antisickling Agents; D006918:Hydroxyurea