title: Increased interleukin-17 producing effector memory T cells in the end-stage renal disease patients.
abstract: Patients with end-stage renal disease (ESRD) exhibit immune dysregulation, but the precise immunological profile and the effect of hemodialysis (HD) on it has not been investigated fully. Thirty-eight ESRD patients (22 on HD and 16 in pre-dialysis) and 24 healthy volunteers were included. We compared the T cell immune profiles as in these patients. Among the effector T cell subset, the percentages of Th17 and Th2 cells were significantly higher in the ESRD group than in the healthy controls (P<0.05). The percentage of Th1 cells did not differ significantly between these groups. The percentages of Th1, Th2 and Th17 cells did not differ significantly (P>0.05) between the two subgroups within the ESRD group. The CCR4(-)CCR6(+)/CD4(+) T cell percentage was also significantly higher in the ESRD group. The naïve T cell (T(naïve)) percentage was significantly lower in the ESRD group, and the difference between patients and controls was greater in the pre-dialysis patients than in the HD patients (P<0.05, for each comparison). By contrast, the percentages of central memory T cells (T(CM)) and effector memory T (T(EM)) cells were significantly higher in the ESRD group. Interleukin-17 production by T(EM) cells was significantly higher in the ESRD group. The severity of uremia was related negatively to the T(naïve) cell percentage but positively to the T(CM) and T(EM) cell percentages. The percentages of T(EM) and CD45RA(+) T effector memory subsets of CD8(+) T cells were significantly higher in the ESRD group (P<0.05). The result of this study showed significantly altered T cell-associated immunity and that it could not be corrected with hemodialysis.
authors: Conversant Research Consorcium in Immunologic Disease, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors: Byung Ha
authors: BH
authors: Chung
authors: Kyoung Woon
authors: KW
authors: Kim
authors: In O
authors: IO
authors: Sun
authors: Sun Ryoung
authors: SR
authors: Choi
authors: Hoon Suk
authors: HS
authors: Park
authors: Eun Joo
authors: EJ
authors: Jeon
authors: Bo-Mi
authors: BM
authors: Kim
authors: Bum Soon
authors: BS
authors: Choi
authors: Cheol Whee
authors: CW
authors: Park
authors: Yong-Soo
authors: YS
authors: Kim
authors: Mi-La
authors: ML
authors: Cho
authors: Chul Woo
authors: CW
authors: Yang
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D002469:Cell Separation; D002478:Cells, Cultured; D018450:Disease Progression; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007156:Immunologic Memory; D020381:Interleukin-17 / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D007676:Kidney Failure, Chronic / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D058504:Th17 Cells / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D015854:Up-Regulation; D014511:Uremia
chemical_list: D015703:Antigens, CD; D020381:Interleukin-17