title: Subtype and pathway specific responses to anticancer compounds in breast cancer.
abstract: Breast cancers are comprised of molecularly distinct subtypes that may respond differently to pathway-targeted therapies now under development. Collections of breast cancer cell lines mirror many of the molecular subtypes and pathways found in tumors, suggesting that treatment of cell lines with candidate therapeutic compounds can guide identification of associations between molecular subtypes, pathways, and drug response. In a test of 77 therapeutic compounds, nearly all drugs showed differential responses across these cell lines, and approximately one third showed subtype-, pathway-, and/or genomic aberration-specific responses. These observations suggest mechanisms of response and resistance and may inform efforts to develop molecular assays that predict clinical response.
authors: Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
authors: Laura M
authors: LM
authors: Heiser
authors: Anguraj
authors: A
authors: Sadanandam
authors: Wen-Lin
authors: WL
authors: Kuo
authors: Stephen C
authors: SC
authors: Benz
authors: Theodore C
authors: TC
authors: Goldstein
authors: Sam
authors: S
authors: Ng
authors: William J
authors: WJ
authors: Gibb
authors: Nicholas J
authors: NJ
authors: Wang
authors: Safiyyah
authors: S
authors: Ziyad
authors: Frances
authors: F
authors: Tong
authors: Nora
authors: N
authors: Bayani
authors: Zhi
authors: Z
authors: Hu
authors: Jessica I
authors: JI
authors: Billig
authors: Andrea
authors: A
authors: Dueregger
authors: Sophia
authors: S
authors: Lewis
authors: Lakshmi
authors: L
authors: Jakkula
authors: James E
authors: JE
authors: Korkola
authors: Steffen
authors: S
authors: Durinck
authors: François
authors: F
authors: Pepin
authors: Yinghui
authors: Y
authors: Guan
authors: Elizabeth
authors: E
authors: Purdom
authors: Pierre
authors: P
authors: Neuvial
authors: Henrik
authors: H
authors: Bengtsson
authors: Kenneth W
authors: KW
authors: Wood
authors: Peter G
authors: PG
authors: Smith
authors: Lyubomir T
authors: LT
authors: Vassilev
authors: Bryan T
authors: BT
authors: Hennessy
authors: Joel
authors: J
authors: Greshock
authors: Kurtis E
authors: KE
authors: Bachman
authors: Mary Ann
authors: MA
authors: Hardwicke
authors: John W
authors: JW
authors: Park
authors: Laurence J
authors: LJ
authors: Marton
authors: Denise M
authors: DM
authors: Wolf
authors: Eric A
authors: EA
authors: Collisson
authors: Richard M
authors: RM
authors: Neve
authors: Gordon B
authors: GB
authors: Mills
authors: Terence P
authors: TP
authors: Speed
authors: Heidi S
authors: HS
authors: Feiler
authors: Richard F
authors: RF
authors: Wooster
authors: David
authors: D
authors: Haussler
authors: Joshua M
authors: JM
authors: Stuart
authors: Joe W
authors: JW
authors: Gray
authors: Paul T
authors: PT
authors: Spellman
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000145:classification* / Q000188:drug therapy* / Q000235:genetics; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005260:Female; D018628:Gene Dosage / Q000235:genetics; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction / Q000187:drug effects* / Q000235:genetics; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents