title: Adenovirus recruits dynein by an evolutionary novel mechanism involving direct binding to pH-primed hexon.
abstract: Following receptor-mediated uptake into endocytic vesicles and escape from the endosome, adenovirus is transported by cytoplasmic dynein along microtubules to the perinuclear region of the cell. How motor proteins are recruited to viruses for their own use has begun to be investigated only recently. We review here the evidence for a role for dynein and other motor proteins in adenovirus infectivity. We also discuss the implications of recent studies on the mechanism of dynein recruitment to adenovirus for understanding the relationship between pathogenic and physiological cargo recruitment and for the evolutionary origins of dynein-mediated adenovirus transport.
authors: Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA. js3203@columbia.edu
authors: Julian
authors: J
authors: Scherer
authors: Richard B
authors: RB
authors: Vallee
mesh_terms: D000256:Adenoviridae / Q000737:chemistry* / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology; D000257:Adenoviridae Infections / Q000821:virology; D001692:Biological Transport; D036022:Capsid Proteins / Q000737:chemistry* / Q000235:genetics; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D056445:Cytoplasmic Dyneins / Q000737:chemistry*; D004705:Endocytosis; D011992:Endosomes / Q000737:chemistry / Q000821:virology; D019143:Evolution, Molecular; D006801:Humans; D006863:Hydrogen-Ion Concentration; D011991:Receptors, Virus / Q000737:chemistry; D053585:Virus Attachment; D053586:Virus Internalization
chemical_list: C568771:CLMP protein, human; D036022:Capsid Proteins; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D011991:Receptors, Virus; C018315:hexon capsid protein, Adenovirus; D056445:Cytoplasmic Dyneins