title: Adiponectin as a marker of complications in type I diabetes.
abstract: OBJECTIVE
  To evaluate adiponectin levels in children and adolescents with type I diabetes, and their relationship to long term complications.
  
  
  METHODS
  Cross sectional.
  
  
  METHODS
  Tertiary referral hospital, Cairo, Egypt.
  
  
  METHODS
  Thirty children and adolescents with type I diabetes mellitus, classified into complicated and non-complicated and compared to 10 healthy age and sex matched subjects as a control group.
  
  
  METHODS
  All children underwent anthropometric measurements, neurological assessment, fundus examination, echocardiography and assays of HbA1c, creatinine, 24-hr urinary protein, and serum adiponectin.
  
  
  METHODS
  Relationship of serum adiponectin to complications of type I diabetes mellitus, and glucose control.
  
  
  RESULTS
  Serum adiponectin was significantly elevated in complicated diabetes (10.3 ± 5.9 pg/dL) as compared to the controls (6.5 ± 3.7 pg/dL) (P<0.01), and correlated directly with HbA1c (P<0.05) and creatinine (P<0.001). Patients with nephropathy showed high values of adiponectin (15.7 ± 3.7 pg/dL).
  
  
  CONCLUSIONS
  Elevated adiponectin level in children and adolescents with type I diabetes indicates poor glycemic control and development of complications, especially nephropathy.
authors: Department of Pediatrics, Ain Shams University, Cairo, Egypt.
authors: Nevin Mohamed Mamdouh
authors: NM
authors: Habeeb
authors: Omneya Ibrahim
authors: OI
authors: Youssef
authors: Azza Abdel Rahman
authors: AA
authors: Saab
authors: Eman Saleh
authors: ES
authors: El Hadidi
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications* / Q000453:epidemiology; D003928:Diabetic Nephropathies / Q000097:blood* / Q000453:epidemiology; D003930:Diabetic Retinopathy / Q000097:blood* / Q000453:epidemiology; D004534:Egypt / Q000453:epidemiology; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D011379:Prognosis
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D006442:Glycated Hemoglobin