title: Photoswitchable click amino acids: light control of conformation and bioactivity.
abstract: Click the switch: By using a photoswitchable click amino acid (PSCaa) a light-induced intramolecular thiol-ene click reaction with a neighboring cysteine under very mild conditions results in an azobenzene bridge. By expanding the genetic code for PSCaa the specific incorporation of photoswitch units into proteins in living cells can result in an exciting approach for studying light-controllable activity, in vivo.
authors: Department Chemical Biology, Leibniz-Institut für Molekulare Pharmakologie, Robert-Rössle-Strasse 10, 13125 Berlin, Germany. hoppmann@fmp-berlin.de
authors: Christian
authors: C
authors: Hoppmann
authors: Peter
authors: P
authors: Schmieder
authors: Nadja
authors: N
authors: Heinrich
authors: Michael
authors: M
authors: Beyermann
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D001391:Azo Compounds / Q000737:chemistry; D057930:Click Chemistry; D003545:Cysteine / Q000737:chemistry; D007536:Isomerism; D008027:Light; D008968:Molecular Conformation; D055668:Photochemical Processes; D013438:Sulfhydryl Compounds / Q000737:chemistry; D054832:Urocortins / Q000737:chemistry
chemical_list: D000596:Amino Acids; D001391:Azo Compounds; D013438:Sulfhydryl Compounds; D054832:Urocortins; C009850:azobenzene; D003545:Cysteine