title: Antifungal sesquiterpenes from Cedrus deodara.
abstract: Two new sesquiterpenes, (E)-(2S,3S,6R)-atlantone-2,3-diol (1) and (E)-(2S,3S,6S)-atlantone-2,3,6-triol (2), along with two known sesquiterpenes, atlantolone (3) and (E)-α-atlantone (4), were isolated from Cedrus deodara Loud. The structures of the new compounds were elucidated on the basis of UV, IR, NMR, HR‑ESI-QTOF‑MS, and EI mass spectral studies. The n-hexane and chloroformextracts of sawdust and compounds 3 and 4 from the plant exhibited antifungal activity against Aspergillus flavus, A. niger, A. ochracoeus, A. parasiticus, and A. sydowii. A weak activity was also recorded against A. parasiticus and A. sydowii for compound 1, while Trichophyton rubrum was inhibited by compound 2 and the extracts.
authors: Natural Plant Products Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, India.
authors: Abha
authors: A
authors: Chaudhary
authors: Swati
authors: S
authors: Sood
authors: Pushpinder
authors: P
authors: Kaur
authors: Neeraj
authors: N
authors: Kumar
authors: Archana
authors: A
authors: Thakur
authors: Arvind
authors: A
authors: Gulati
authors: Bikram
authors: B
authors: Singh
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects*; D028203:Cedrus / Q000737:chemistry*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D014249:Trichophyton / Q000187:drug effects*; D014934:Wood
chemical_list: C573211:(E)-(2S,3S,6R)-atlantone-2,3-diol; C573212:(E)-(2S,3S,6S)-atlantone-2,3,6-triol; D000935:Antifungal Agents; D010936:Plant Extracts; D012717:Sesquiterpenes