title: Renal function in type 1 diabetics one year after successful pancreas transplantation.
abstract: The effect of pancreas transplantation on renal function remains a matter of debate. The purpose of this retrospective, single-unit study is a preliminary analysis of renal function one yr after pancreas transplant (pancreas alone [PTA] or pancreas after kidney [PAK]). Fifty-nine patients were included. Serum creatinine and estimated glomerular filtration rate (eGFR) levels were compared three, six, and 12 months post-transplantation for the whole sample and separately for PTA and PAK and high (>45 mL/min/1.73 m(2)) and low (≤45 mL/min/1.73 m(2)) pre-transplant eGFR subgroups. Overall, eGFR did not change significantly (p = 0.228) at the end of the first year post-transplant, with patients of low initial eGFR presenting a more prominent trend toward stable or improved levels. In the PAK subgroup, eGFR was significantly improved (p = 0.035). High eGFR subgroup demonstrated no significant deterioration in renal function, while patients with low initial eGFR had significantly higher levels 3 (p = 0.012) and six months (p = 0.009) post-transplant. Our study shows that renal function did not deteriorate significantly one yr after pancreas transplant (PTA or PAK), even in patients with substantial pre-existing renal dysfunction. Evaluation at a wider scale and identification of risk factors for potential deterioration are challenges for future research.
authors: Oxford Transplant Centre, Churchill Hospital, Oxford, UK.
authors: Nikolaos A
authors: NA
authors: Chatzizacharias
authors: Anil
authors: A
authors: Vaidya
authors: Sanjay
authors: S
authors: Sinha
authors: Richard
authors: R
authors: Smith
authors: Gareth
authors: G
authors: Jones
authors: Edward
authors: E
authors: Sharples
authors: Peter J
authors: PJ
authors: Friend
mesh_terms: D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000401:mortality* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D016035:Pancreas Transplantation; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate