title: Dual properties of anticancer agents: an exploratory study on the in vitro anti-Candida properties of thirty drugs.
abstract: BACKGROUND
  Anticancer/antineoplastic agents could be a good resource for the discovery of novel antifungal agents and targets since human beings share a common eukaryotic heritage with fungi.
  
  
  METHODS
  Thirty commonly prescribed anticancer drugs belonging to 12 different classes were analyzed for their effects on the growth of Candida albicans. Minimum inhibitory concentrations (MICs) were obtained using standard CLSI-M27 A2 methodology, and minimal fungicidal concentrations (MFCs) were determined via the agar plate method.
  
  
  RESULTS
  Anticancer agents inhibited the growth of C. albicans in a concentration-dependent manner. Nine drugs from different classes were effective at low concentrations (≤50 μg·ml(-1)), while 15 anticancer drugs exhibited MICs of 100 μg·ml(-1). Sixteen out of 30 drugs exerted fungicidal activity in the range of 400-800 μg·ml(-1).
  
  
  CONCLUSIONS
  MICs and MFCs for 30 anticancer drugs were established against C. albicans. Our study highlighted the anti-Candida potential of these drugs, which may give insights to unexplored targets for antifungal chemotherapy.
authors: DST-FIST Sponsored School of Life Sciences, SRTM University, Nanded, India.
authors: Madhushree M
authors: MM
authors: Routh
authors: Jayant S
authors: JS
authors: Raut
authors: S Mohan
authors: SM
authors: Karuppayil
mesh_terms: D000935:Antifungal Agents / Q000145:classification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000145:classification / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D008826:Microbial Sensitivity Tests
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents