title: Of fat, β cells, and diabetes.
abstract: The molecular mechanisms linking diet, obesity, and type 2 diabetes are still poorly understood. In a recent paper, Ohtsubo et al. (2011) show that high lipid levels induce nuclear exclusion of Foxa2 and HNF1α in β cells, leading to impaired expression and glycosylation of proteins controlling glucose-stimulated insulin secretion.
authors: Center for Integrative Genomics, University of Lausanne, CH-1015 Lausanne, Switzerland. bernard.thorens@unil.ch
authors: Bernard
authors: B
authors: Thorens