title: Filovirus outbreak detection and surveillance: lessons from Bundibugyo.
abstract: The first outbreak of Ebola hemorrhagic fever (EHF) due to Bundibugyo ebolavirus occurred in Uganda from August to December 2007. During outbreak response and assessment, we identified 131 EHF cases (44 suspect, 31 probable, and 56 confirmed). Consistent with previous large filovirus outbreaks, a long temporal lag (approximately 3 months) occurred between initial EHF cases and the subsequent identification of Ebola virus and outbreak response, which allowed for prolonged person-to-person transmission of the virus. Although effective control measures for filovirus outbreaks, such as patient isolation and contact tracing, are well established, our observations from the Bundibugyo EHF outbreak demonstrate the need for improved filovirus surveillance, reporting, and diagnostics, in endemic locations in Africa.
authors: Viral Special Pathogens Branch, The Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. aho3@cdc.gov
authors: Adam
authors: A
authors: MacNeil
authors: Eileen C
authors: EC
authors: Farnon
authors: Oliver W
authors: OW
authors: Morgan
authors: Philip
authors: P
authors: Gould
authors: Tegan K
authors: TK
authors: Boehmer
authors: David D
authors: DD
authors: Blaney
authors: Petra
authors: P
authors: Wiersma
authors: Jordan W
authors: JW
authors: Tappero
authors: Stuart T
authors: ST
authors: Nichol
authors: Thomas G
authors: TG
authors: Ksiazek
authors: Pierre E
authors: PE
authors: Rollin
mesh_terms: D004196:Disease Outbreaks; D019142:Hemorrhagic Fever, Ebola / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D006801:Humans; D011159:Population Surveillance / Q000379:methods*; D014454:Uganda / Q000453:epidemiology