title: ITPKC and CASP3 polymorphisms and risks for IVIG unresponsiveness and coronary artery lesion formation in Kawasaki disease.
abstract: Functional single-nucleotide polymorphisms (SNPs) in inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) (rs28493229) and caspase-3 (CASP3) (rs113420705; formerly rs72689236) are associated with susceptibility to Kawasaki's disease (KD). To evaluate the involvement of these 2 SNPs in the risk for intravenous immunoglobulin (IVIG) unresponsiveness, we investigated 204 Japanese KD patients who received a single IVIG dose of 2 g kg(-1) (n=70) or 1 g kg(-1) daily for 2 days (n=134). The susceptibility allele of both SNPs showed a trend of overrepresentation in IVIG non-responders and, in combined analysis of these SNPs, patients with at least 1 susceptible allele at both loci had a higher risk for IVIG unresponsiveness (P=0.0014). In 335 prospectively collected KD patients who were treated with IVIG (2 g kg(-1)), this 2-locus model showed a more significant association with resistance to initial and additional IVIG (P=0.011) compared with individual SNPs. We observed a significant association when all KD patients with coronary artery lesions were analyzed with the 2-locus model (P=0.0031). Our findings strongly suggest the existence of genetic factors affecting patients' responses to treatment and the risk for cardiac complications, and provide clues toward understanding the pathophysiology of KD inflammation.
authors: Laboratory for Cardiovascular Diseases, Center for Genomic Medicine RIKEN, Yokohama, Kanagawa, Japan. onouchi@src.riken.jp
authors: Y
authors: Y
authors: Onouchi
authors: Y
authors: Y
authors: Suzuki
authors: H
authors: H
authors: Suzuki
authors: M
authors: M
authors: Terai
authors: K
authors: K
authors: Yasukawa
authors: H
authors: H
authors: Hamada
authors: T
authors: T
authors: Suenaga
authors: T
authors: T
authors: Honda
authors: A
authors: A
authors: Honda
authors: H
authors: H
authors: Kobayashi
authors: T
authors: T
authors: Takeuchi
authors: N
authors: N
authors: Yoshikawa
authors: J
authors: J
authors: Sato
authors: S
authors: S
authors: Shibuta
authors: M
authors: M
authors: Miyawaki
authors: K
authors: K
authors: Oishi
authors: H
authors: H
authors: Yamaga
authors: N
authors: N
authors: Aoyagi
authors: S
authors: S
authors: Iwahashi
authors: R
authors: R
authors: Miyashita
authors: Y
authors: Y
authors: Murata
authors: R
authors: R
authors: Ebata
authors: K
authors: K
authors: Higashi
authors: K
authors: K
authors: Ozaki
authors: K
authors: K
authors: Sasago
authors: T
authors: T
authors: Tanaka
authors: A
authors: A
authors: Hata
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D053148:Caspase 3 / Q000235:genetics*; D002648:Child; D003331:Coronary Vessels / Q000201:enzymology / Q000473:pathology*; D004351:Drug Resistance; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000201:enzymology / Q000235:genetics* / Q000473:pathology*; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies
chemical_list: D016756:Immunoglobulins, Intravenous; D017853:Phosphotransferases (Alcohol Group Acceptor); C051038:Inositol 1,4,5-trisphosphate 3-kinase; C505407:CASP3 protein, human; D053148:Caspase 3