title: Organophosphorous pesticides research in Mexico: epidemiological and experimental approaches.
abstract: Non-persistent pesticides, such as organophosphorous (OP) insecticides have been extensively used in Mexico, and becoming a public health problem. This review presents data of OP use and related toxicity from epidemiological and experimental studies conducted in Mexico. Studies in agricultural workers from several regions of the country reported moderate to severe cholinergic symptoms, including decreased acetylcholinesterase (AChE) activity (the main acute OP toxic effect that causes an over accumulation of the neurotransmitter acetylcholine), revealing the potential risk of intoxication of Mexican farmers. OP exposure in occupational settings has been associated with decreased semen quality, sperm DNA damage and as endocrine disrupter, particularly in agricultural workers. Alterations in female reproductive function have also been observed, as well as adverse effects on embryo development by prenatal exposure in agricultural communities. This illustrates that OP exposure represents a risk for reproduction and offspring well-being in Mexico. The genotoxic effects of this group of pesticides in somatic and sperm cells are also documented. Lastly, we present data about gene-environmental interactions regarding OP metabolizing enzymes, such as paraoxonase-1 (PON1) and its role in modulating their toxicity, particularly on semen quality and sperm DNA integrity. In summary, readers will see the important health problems associated with OP exposure in Mexican populations, thereby the need of capacitation programs to communicate farmers the proper handling of agrochemicals to prevent their toxic effects and of more well designed human studies to support data of the current situation of workers and communities dedicated to agriculture activities.
authors: Departamento de Toxicología, CINVESTAV-IPN, Mexico.
authors: M
authors: M
authors: Sánchez-Guerra
authors: N
authors: N
authors: Pérez-Herrera
authors: B
authors: B
authors: Quintanilla-Vega
mesh_terms: D004249:DNA Damage / Q000187:drug effects; D006801:Humans; D008297:Male; D008800:Mexico; D009943:Organophosphorus Compounds / Q000494:pharmacology* / Q000633:toxicity; D010575:Pesticides / Q000494:pharmacology* / Q000633:toxicity; D012661:Semen / Q000187:drug effects
chemical_list: D009943:Organophosphorus Compounds; D010575:Pesticides