title: Estradiol plus drospirenone therapy increases mammographic breast density in perimenopausal women.
abstract: OBJECTIVE
  To investigate the effects of 17β-estradiol 1mg plus drospirenone 2mg (E2/DRSP) treatment on mammographic breast density in perimenopausal women.
  
  
  METHODS
  In this prospective study, 80 healthy perimenopausal women aged 41-49 years were enrolled and assigned to either E2/DRSP (n=40) or a control group (n=40). Mammograms were performed at baseline and after 12 months of treatment. Mammographic breast density was quantified according to the Wolfe classification.
  
  
  RESULTS
  We demonstrated an increase in mammographic breast density in 37% (95% CI (confidence interval): 18.8-55.3%) of women treated with E2/DRSP after 12 months. The percentage of women with increased density was 0% (95% CI: 0.0-0.0%) in the control group. The difference in breast density between the E2/DRSP group and the control group was statistically very significant (p<0.001).
  
  
  CONCLUSIONS
  E2/DRSP therapy for 12 months in perimenopausal women significantly increased mammographic breast density in comparison to a control group. Further long-term and large scale prospective studies are needed to evaluate this issue.
authors: Department of Obstetrics and Gynecology, Kahramanmaras Sutcuimam University School of Medicine, Kahramanmaras, Turkey. hakankiran01@yahoo.com
authors: Hakan
authors: H
authors: Kiran
authors: Abdullah
authors: A
authors: Tok
authors: Mürvet
authors: M
authors: Yüksel
authors: Deniz Cemgil
authors: DC
authors: Arikan
authors: Hasan Cetin
authors: HC
authors: Ekerbicer
mesh_terms: D000328:Adult; D000726:Androgen Antagonists / Q000009:adverse effects / Q000494:pharmacology*; D000736:Androstenes / Q000009:adverse effects / Q000494:pharmacology*; D004338:Drug Combinations; D055088:Early Detection of Cancer; D004958:Estradiol / Q000009:adverse effects / Q000494:pharmacology*; D015914:Estrogen Replacement Therapy / Q000009:adverse effects; D005260:Female; D006801:Humans; D042361:Mammary Glands, Human / Q000187:drug effects*; D008327:Mammography; D008875:Middle Aged; D008901:Mineralocorticoids / Q000037:antagonists & inhibitors*; D047648:Perimenopause
chemical_list: D000726:Androgen Antagonists; D000736:Androstenes; D004338:Drug Combinations; D008901:Mineralocorticoids; C488382:estradiol-drospirenone combination; D004958:Estradiol