title: Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules.
abstract: Ru(II)(arene) anticancer compounds with maleimide functionality were prepared to allow selective interaction with thiol-containing biomolecules and thereby enforcing the selective delivery of the compounds to the tumour.
authors: University of Vienna, Institute of Inorganic Chemistry, Waehringer Str. 42, A-1090 Vienna, Austria.
authors: Muhammad
authors: M
authors: Hanif
authors: Alexey A
authors: AA
authors: Nazarov
authors: Anton
authors: A
authors: Legin
authors: Michael
authors: M
authors: Groessl
authors: Vladimir B
authors: VB
authors: Arion
authors: Michael A
authors: MA
authors: Jakupec
authors: Yury O
authors: YO
authors: Tsybin
authors: Paul J
authors: PJ
authors: Dyson
authors: Bernhard K
authors: BK
authors: Keppler
authors: Christian G
authors: CG
authors: Hartinger
mesh_terms: D000111:Acetylcysteine / Q000031:analogs & derivatives / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001665:Binding Sites; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003545:Cysteine / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D005978:Glutathione / Q000737:chemistry; D006801:Humans; D008301:Maleimides / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D012428:Ruthenium / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D008301:Maleimides; D009942:Organometallic Compounds; D013438:Sulfhydryl Compounds; C043592:maleimide; D012428:Ruthenium; D005978:Glutathione; D003545:Cysteine; D000111:Acetylcysteine