title: Complications and adverse events associated with Neuroform stent-assisted coiling of wide-neck intracranial aneurysms.
abstract: BACKGROUND
  Successful experiences of the Neuroform stent-assisted coiling have been reported by many teams in endovascular neurosurgery centers throughout the world. However, most of the reported complications involved a limited number of patients.
  
  
  OBJECTIVE
  To systematically report the complications of Neuroform stent-assisted coiling of intracranial aneurysms and to tentatively assess the efficacy and safety of this method.
  
  
  METHODS
  A retrospective study of 232 consecutive patients with 239 wide-neck aneurysms treated with Neuroform  stent-assisted coil embolization at our institution over a 6-year period was performed. Angiographic results and clinical outcome were evaluated. Cases with complications were analyzed.
  
  
  RESULTS
  Stenting was successful in 237 of 239 aneurysms. Favorable clinical outcome (modified  Rankin score: 0-2) was observed in 88·3% of the patients. Procedure-related complications included thromboembolism (n = 13), intraprocedural rupture (n=8), coil protrusions (n=5), new mass effect (n=3),  vessel injury (n=3), and stent dislodgement (n=2). Procedure-related morbidity and mortality were 4·2 and 1·3%, respectively. Non-procedural complications attributable to subarachnoid hemorrhage in 129 patients with ruptured aneurysms were  symptomatic vasospasm (18·6%) and shunt-dependent hydrocephalus (6·9%). Angiography follow-up was obtained in 67·1% of the treated aneurysms. The overall recanalization rate was 14·5%. Delayed complications included in-stent stenosis (n=2) and  penetrating artery occlusion (n=2) in follow-up period.
  
  
  CONCLUSIONS
  Neuroform sent-assisted coiling of intracranial aneurysm is a safe technique with relatively low recanalization rate. The main cause of morbidity and mortality is thromboembolism. Long-term effect  on parent artery should be observed carefully.
authors: Department of Neurosurgery, the General Hospital of Shenyang Military Command, Shenyang, China.
authors: Xu
authors: X
authors: Gao
authors: Guobiao
authors: G
authors: Liang
authors: Zhiqing
authors: Z
authors: Li
authors: Xuezhong
authors: X
authors: Wei
authors: Qu
authors: Q
authors: Hong
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001807:Blood Vessel Prosthesis / Q000009:adverse effects*; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects* / Q000379:methods / Q000401:mortality; D002533:Cerebral Angiography / Q000379:methods; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000379:methods* / Q000401:mortality; D012189:Retrospective Studies; D015607:Stents / Q000009:adverse effects*