title: Sodium Tripolyphosphate: an excipient with intrinsic in vitro anti-Candida activity.
abstract: Sodium Tripolyphosphate (STPP) is a food additive that is being used in the development of micro and nanoparticles as it induces ionic interactions with chitosan molecules. Although the ability of STPP to inhibit the growth of several food contaminants has been reported, studies on its activity against clinical isolates are scarce. Candida spp. are common causative agents of mucocutaneous infections including the vulvovaginal tegument and new therapeutic approaches are needed in order to treat resistant and recurrent cases. The aim of this study was to evaluate in vitro both antifungal (anti-Candida spp.) activity, and cytotoxicity, on human dermal fibroblasts, of STPP solutions. STPP showed an inhibitory species-dependent activity against several Candida spp. strains being particularly active on C. glabrata, followed by C. guilliermondii. In vitro, STPP showed a concentration dependent cytotoxicity. Therefore STPP use, in low concentrations, seems to be interesting in the development of drug delivery systems for the treatment of vulvovaginal candidosis.
authors: CICS-UBI - Health Sciences Research Centre, University of Beira Interior, Av. Infante D. Henrique, 6200-506, Covilhã, Portugal. rpo@fcsaude.ubi.pt
authors: R
authors: R
authors: Palmeira-de-Oliveira
authors: A
authors: A
authors: Palmeira-de-Oliveira
authors: C
authors: C
authors: Gaspar
authors: S
authors: S
authors: Silvestre
authors: J
authors: J
authors: Martinez-de-Oliveira
authors: M H
authors: MH
authors: Amaral
authors: L
authors: L
authors: Breitenfeld
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000254:growth & development; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D005079:Excipients / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects; D005503:Food Additives / Q000494:pharmacology; D006801:Humans; D011122:Polyphosphates / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D005079:Excipients; D005503:Food Additives; D011122:Polyphosphates; C005692:triphosphoric acid