title: [Protective effect of hydroxysafflor yellow A on endothelial cell injury induced by lipopolysaccharide].
abstract: To observe the protective effect of hydroxyl safflor yellow A (HSYA) on endothelial cell (EC). It has been observed by RT-PCR that HSYA can inhibit the elevation of TNF-alpha, IL-6, ICAM-1 and VCAM-1 mRNA level induced by LPS. The result of immunofluorescence test suggested that HSYA can alleviate p65 subgroup of NF-kappaB nuclear translocation. The experiment on EA-HY926 cell line proved that HSYA can protect EC against inflammation injury.
authors: Department of Pharmacology, Beijing Institute of Heart Lung and Blood Vessel Diseases-Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China. wangxiaofei610@sina.com
authors: Xiaofei
authors: X
authors: Wang
authors: Baoxia
authors: B
authors: Zang
authors: Wei
authors: W
authors: Wu
authors: Jing
authors: J
authors: Tong
authors: Ming
authors: M
authors: Jin
mesh_terms: D002460:Cell Line; D002599:Chalcone / Q000031:analogs & derivatives* / Q000494:pharmacology; D042783:Endothelial Cells / Q000187:drug effects* / Q000378:metabolism*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008070:Lipopolysaccharides / Q000633:toxicity*; D016328:NF-kappa B / Q000378:metabolism; D011809:Quinones / Q000494:pharmacology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism
chemical_list: D015850:Interleukin-6; D008070:Lipopolysaccharides; D016328:NF-kappa B; D011809:Quinones; D014409:Tumor Necrosis Factor-alpha; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1; C085278:hydroxysafflor yellow A; D002599:Chalcone