title: [Predictors of axillary node metastasis at breast surgery after neoadjuvant chemotherapy in patients with pre- chemotherapy-sentinel node positive breast cancer].
abstract: BACKGROUND
  We investigated predictors for axillary node metastasis at breast surgery after neoadjuvant chemotherapy (NAC) in patients with pre-chemotherapy-sentinel node positive breast cancer.
  
  
  METHODS
  Eighty-two patients were diagnosed as having positive sentinel lymph node (SLN), who had axillary lymph node dissection (ALND) performed after combination anthracycline/taxan based NAC, between 2002 and 2009.
  
  
  RESULTS
  Eighteen (22.0%) of the 82 patients had residual axillary metastases after NAC. Multivariate analysis revealed that SLNs status before NAC was an important factor in predicting residual axillary metastases. Predictors of residual nodal disease were the number of macrometastases and the percentage (>50%) of positive SLNs in all SLNs. Among a subgroup of hormone-receptor positive and HER2-negative tumors, the risk of residual nodal metastases were high sensitivity of hormone receptor, with more than 50% of tumor cells staining positive for ER and PgR.
  
  
  CONCLUSIONS
  Patients with two or more positive SLNs before NAC had a high risk of residual nodal metastasis after NAC.
authors: Department of Breast Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
authors: Hiromi
authors: H
authors: Tokita
authors: Tomoyuki
authors: T
authors: Aruga
authors: Toshinari
authors: T
authors: Yamashita
authors: Shigehira
authors: S
authors: Saji
authors: Eiji
authors: E
authors: Suzuki
authors: Kazumi
authors: K
authors: Horiguchi
authors: Dai
authors: D
authors: Kitagawa
authors: Susumu
authors: S
authors: Sekine
authors: Shin-ichiro
authors: S
authors: Horiguchi
authors: Yuka
authors: Y
authors: Hirashima
authors: Katsumasa
authors: K
authors: Kuroi
mesh_terms: D000328:Adult; D000368:Aged; D001365:Axilla / Q000473:pathology; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008408:Mastectomy; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D021701:Sentinel Lymph Node Biopsy