title: Discovery of small molecules that enhance astrocyte differentiation in rat fetal neural stem cells.
abstract: 1,3,4-Oxadiazole derivatives were found to enhance astrocyte differentiation in rat fetal neural stem cells (NSCs). Differentiation activity was assessed by immunocytochemistry and analysis of mRNA expression of astrocyte markers, GFAP and S100. Compounds 7 and 8 showed approximately a two-fold increase in astrocyte differentiation without engagement of neuronal differentiation and detectable cytotoxicity.
authors: College of Pharmacy, Seoul National University, Seoul, Republic of Korea.
authors: Dong Jo
authors: DJ
authors: Chang
authors: Mi Young
authors: MY
authors: Jeong
authors: Jiho
authors: J
authors: Song
authors: Chang Yun
authors: CY
authors: Jin
authors: Young-Ger
authors: YG
authors: Suh
authors: Hyun-Jung
authors: HJ
authors: Kim
authors: Kyung Hoon
authors: KH
authors: Min
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects*; D056148:Chromatography, Reverse-Phase; D053686:Fetal Stem Cells / Q000166:cytology* / Q000187:drug effects*; D005904:Glial Fibrillary Acidic Protein / Q000235:genetics / Q000378:metabolism; D007150:Immunohistochemistry; D015394:Molecular Structure; D058953:Neural Stem Cells / Q000166:cytology* / Q000187:drug effects*; D010069:Oxadiazoles / Q000737:chemistry* / Q000494:pharmacology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D009418:S100 Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D005904:Glial Fibrillary Acidic Protein; D010069:Oxadiazoles; D012333:RNA, Messenger; D009418:S100 Proteins