title: Damnacanthal-induced anti-inflammation is associated with inhibition of NF-κB activity.
abstract: Morinda citrifolia L. (Rubiaceae), commonly called noni, is a traditional folk medicinal plant with a long history of use for several diseases. Its anti-inflammation activity has been proposed, but detailed knowledge of this antiinflammation mechanism remains unclear. Here, we investigated the effects of noni extract and its major bioactive component damnacanthal on anti-inflammation in vivo as well as in vitro. Our data demonstrate that noni extract and its bioactive component damnacanthal exhibit suppression of inflammation as evidenced by the suppression of paw and ear edema in rats and mice, and down-regulation of lipopolysaccharide-induced nuclear factor-κB (NF-κB) activity, respectively. As a result, the expression of pro-cytokines, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) were suppressed in the presence of damnacanthal. These results provide a potential use of damnacanthal in the treatment of inflammatory-related diseases.
authors: Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, 37996, USA.
authors: Thararat
authors: T
authors: Nualsanit
authors: Pleumchitt
authors: P
authors: Rojanapanthu
authors: Wandee
authors: W
authors: Gritsanapan
authors: Thiwanporn
authors: T
authors: Kwankitpraniti
authors: Kyung-Won
authors: KW
authors: Min
authors: Seung Joon
authors: SJ
authors: Baek
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D002460:Cell Line; D005638:Fruit; D006801:Humans; D008297:Male; D051379:Mice; D032066:Morinda; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000378:metabolism* / Q000502:physiology; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D018517:Plant Roots; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000880:Anthraquinones; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016328:NF-kappa B; D010936:Plant Extracts; C079170:damnacanthal