title: Systematic review of parkinsonian syndromes in short- and long-term survivors of paraquat poisoning.
abstract: OBJECTIVE
  The objective of this study was to assess whether high-dose paraquat exposure was associated with the development of parkinsonism.
  
  
  METHODS
  We carried out a systematic review of all published cases of paraquat toxicity meeting a case-definition of paraquat poisoning and who either recovered or lived for at least 30 days (primary analysis) or lived for 15 to 30 days (secondary analysis). Cases were included if they contained sufficient information to determine whether they had signs of parkinsonism.
  
  
  RESULTS
  Our search yielded 818 publications containing 83 cases. The primary analysis yielded 70 cases. None manifested signs of parkinsonism. An additional 13 were in the secondary analysis and none exhibited signs of parkinsonism.
  
  
  CONCLUSIONS
  An analysis the world's entire published experience found no connection between high-dose paraquat exposure in humans and the development of parkinsonism.
authors: Toxicology Associates, Denver, Colorado 80210, USA. Jeffrey.brent@ucdenver.edu
authors: Jeffrey
authors: J
authors: Brent
authors: Tammi H
authors: TH
authors: Schaeffer
mesh_terms: D006540:Herbicides / Q000008:administration & dosage / Q000506:poisoning*; D006801:Humans; D010269:Paraquat / Q000008:administration & dosage / Q000506:poisoning*; D020734:Parkinsonian Disorders / Q000139:chemically induced* / Q000503:physiopathology; D017741:Survivors
chemical_list: D006540:Herbicides; D010269:Paraquat