title: Electrically controlled molecular recognition harnessed to activate a cellular response.
abstract: Seamless embedment of electronic devices in biological systems is expected to add the outstanding computing power, memory, and speed of electronics to the biochemical toolbox of nature. Such amalgamation requires transduction of electronic signals into biochemical cues that affect cells. Inspired by biology, where pathways are directed by molecular recognition, we propose and demonstrate a generic electrical-to-biological transducer comprising a two-state electronic antigen and a chimeric cell receptor engineered to bind the antigen exclusively in its "on" state. T-cells expressing these receptors remain inactivated with the antigen in its "off" state. Switching the antigen to its "on" state by an electrical signal leads to its recognition by the T-cells and correspondingly to cell activation.
authors: Department of Biology, Technion-Israel Institute of Technology, Haifa 32000, Israel.
authors: Arbel
authors: A
authors: Artzy-Schnirman
authors: Dan
authors: D
authors: Blat
authors: Yael
authors: Y
authors: Talmon
authors: Rami
authors: R
authors: Fishler
authors: Dori
authors: D
authors: Gertman
authors: Ravit
authors: R
authors: Oren
authors: Ron
authors: R
authors: Wolchinsky
authors: Tova
authors: T
authors: Waks
authors: Itai
authors: I
authors: Benhar
authors: Zelig
authors: Z
authors: Eshhar
authors: Uri
authors: U
authors: Sivan
authors: Yoram
authors: Y
authors: Reiter
mesh_terms: D002478:Cells, Cultured; D004574:Electromagnetic Fields; D006801:Humans; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry / Q000528:radiation effects*; D057127:Single-Chain Antibodies / Q000737:chemistry / Q000528:radiation effects*; D013601:T-Lymphocytes / Q000737:chemistry / Q000528:radiation effects*
chemical_list: D011948:Receptors, Antigen, T-Cell; D057127:Single-Chain Antibodies