title: Ron receptor overexpression in the murine prostate induces prostate intraepithelial neoplasia.
abstract: Previous studies have shown that the Ron receptor is overexpressed in prostate cancer and Ron expression increases with disease severity in humans and the mouse TRAMP model. Here, the causal role of Ron overexpression in the murine prostate was examined in the development and progression of prostate cancer. Transgenic mouse strains were generated which selectively overexpressed Ron in the prostate epithelium and prostate histopathology was evaluated and compared to wild type controls. Ron overexpression led to the development of prostate intraepithelial neoplasia (mPIN) with local invasion and was associated with increases in prostate cell proliferation and decreases in cell death.
authors: Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0521, United States.
authors: Jerilyn K
authors: JK
authors: Gray
authors: Andrew M
authors: AM
authors: Paluch
authors: William D
authors: WD
authors: Stuart
authors: Susan E
authors: SE
authors: Waltz
mesh_terms: D000818:Animals; D017209:Apoptosis; D049109:Cell Proliferation; D020287:In Situ Nick-End Labeling; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D011467:Prostate / Q000737:chemistry / Q000473:pathology; D019048:Prostatic Intraepithelial Neoplasia / Q000209:etiology* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000209:etiology* / Q000473:pathology; D020794:Receptor Protein-Tyrosine Kinases / Q000032:analysis / Q000502:physiology*; D015398:Signal Transduction
chemical_list: C080835:RON protein; D020794:Receptor Protein-Tyrosine Kinases