title: Conditionally replicating adenoviruses carrying mda-7/IL-24 for cancer therapy.
abstract: BACKGROUND
  Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) suppresses growth and induces apoptosis in a broad range of human cancers without significant cytotoxicity to normal cells. Conditionally replicating adenoviruses (CRAds) not only have the ability to destroy cancer cells but may also be potential vectors for the expression of therapeutic genes.
  
  
  METHODS
  This review provides an overview of specifications for a novel anti-tumor approach CRAds carrying IL-24, and discusses recent progress in this field.
  
  
  RESULTS
  Studies in multiple laboratories report that CRAds carrying IL-24 selectively induced apoptosis in some cancer cells, and enhanced selective toxicity to cancer cells when combined with chemotherapeutic agents.
  
  
  CONCLUSIONS
  CRAds carrying IL-24 may prove a novel and effective approach for the treatment of cancers.
authors: Laboratory of Biological Cancer Therapy, Xuzhou Medical College, Xuzhou, China.
authors: Guan
authors: G
authors: Jiang
authors: Lei
authors: L
authors: Zhang
authors: Yong
authors: Y
authors: Xin
authors: Dong-Sheng
authors: DS
authors: Pei
authors: Zhi-Ping
authors: ZP
authors: Wei
authors: Yan-Qun
authors: YQ
authors: Liu
authors: Jun-Nian
authors: JN
authors: Zheng
mesh_terms: D000256:Adenoviridae / Q000235:genetics*; D017209:Apoptosis; D015316:Genetic Therapy; D006801:Humans; D007378:Interleukins / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy*; D014779:Virus Replication / Q000502:physiology*; D000099180:Interleukin-24
chemical_list: D007378:Interleukins; D000099180:Interleukin-24