title: Antibiotic control of tumor-colonizing Salmonella enterica serovar Typhimurium.
abstract: Systemic administration of Salmonella enterica serovar Typhimurium (S. typhimurium) into tumor-bearing mice results in preferential colonization of tumors and causes shrinkage and sometimes complete tumor clearance. However, in spite of these beneficial antitumor effects, the systemic administration of a bacterial pathogen raises serious safety concerns as well. Addressing those concerns, here, we demonstrate that tumor-colonizing Salmonella can be readily controlled by systemic administration of the antibiotic - ciprofloxacin. Treatment was most effective when started early postinfection. This was achieved at the expense of the efficacy of tumor therapy. In many of the mice treated in such a way, tumors re-grew again. Nevertheless, some mice were able to clear the tumor despite the start of antibiotic treatment only 24 h after the start of infection. Furthermore, we could demonstrate that such mice had elicited a specific antitumor immune response. Thus, S. typhimurium-mediated tumor therapy might be applied safely when combined with early antibiotic treatment. However, the therapeutic power of the bacteria needs to be enhanced in order to provide a more effective therapeutic tool.
authors: Molecular Immunology, HZI - Helmholtz Centre for Infection Research, Inhoffenstr 7, D-38124 Braunschweig,  Germany.
authors: Katja
authors: K
authors: Crull
authors: Siegfried
authors: S
authors: Weiss
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002277:Carcinoma / Q000276:immunology / Q000382:microbiology* / Q000628:therapy; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000276:immunology / Q000382:microbiology* / Q000628:therapy; D004195:Disease Models, Animal; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D012480:Salmonella Infections / Q000188:drug therapy*; D012486:Salmonella typhimurium / Q000187:drug effects*
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin