title: Dynamic pain after laser-assisted-Uvulo-palatoplasty (LAUP) can instantaneously be mitigated by topical regimens.
abstract: OBJECTIVE
  Kenalog application onto surgical wounds has been used to control dynamic pain following Laser-Assisted-Uvulo-Palatoplasty (LAUP) with good results in our department. When the effect was sub-optimal, insufficient ointment over the superior-lateral corner of wounds were always noted. Fulfilling the coating led to optimal results, and preliminary trials showed a good outcome of dynamic pain control as well by treating the corners only. The corners were thus named "sweet spots." This study aimed to verify the efficacy of applying Kenalog on "sweet spots" instead of whole surgical wounds to mitigate dynamic pain due to LAUP.
  
  
  METHODS
  This is an outcomes research. Fifty-five subjects with primary snoring treated with LAUP were studied. By using Kenalog, local treatments were applied to sweet spots during the first postoperative week. A visual analogous scale was used to evaluate dynamic pain on the 1st, 2nd, 3rd, and 7th days after LAUP.
  
  
  RESULTS
  Once sweet spots were treated, there was instant alleviation of dynamic pain; the average improvement level was ≥80% (P < 0.001, power = 100%). The area of sweet spots, in contrast to the significant relief in dynamic pain, occupied only about 30% of denuded mucosa.
  
  
  CONCLUSIONS
  Dynamic pain after LAUP could immediately be mitigated by local treatments upon sweet spots using topical regimens. The large-scale relief of dynamic pain in contrast to the small area of sweet spots implies a congregation of free nerve endings there. Our finding invites further studies to correlate the neuroanatomy of the soft palate and dynamic pain caused by LAUP.
authors: Department of Otolaryngology, Cheng Hsin General Hospital, Taipei, Taiwan.
authors: Lieber P H
authors: LP
authors: Li
authors: Shan S
authors: SS
authors: Lee
authors: Ann Y C
authors: AY
authors: Chuang
authors: David M
authors: DM
authors: Niddam
authors: Tao H
authors: TH
authors: Tung
authors: Joshua K C
authors: JK
authors: Chen
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*; D010159:Palate / Q000601:surgery*; D012074:Remission Induction; D012913:Snoring / Q000601:surgery*; D013997:Time Factors; D014222:Triamcinolone Acetonide / Q000008:administration & dosage*; D014609:Uvula / Q000601:surgery*; D055815:Young Adult
chemical_list: D014222:Triamcinolone Acetonide