title: [Measurements of TMR, Absorbed Dose using Long SSD TBI Dosimetry and Calculation Accuracy of Treatment Planning System].
abstract: Over the last 50 years, total body irradiation (TBI) has become widely used in conditioning regimens for the treatment of hematological malignancies prior to bone marrow or peripheral blood stem cell transplantation. Many techniques and prescriptions have been proposed, and the use of a treatment planning system (TPS) may be best in terms of preventing toxicity to normal tissues and insufficient low dose in bone marrow. Since many measurement data in TPS can be applied at source axis distance (SAD) (1 m), absorbed dose at long source surface distance (SSD) calculated by TPS must be verified prior to clinical use. The aim of this study is to evaluate the difference between (1) TMR measured at long SSD (4 m) and TMR at SAD and (2) the absorbed dose measured at long SSD and the absorbed dose calculated by TPS. TMR measured at long SSD agreed with TMR at SAD within 2.0%, while absorbed dose measured at long SSD agreed with that calculated by TPS within 2.5%. These verifications show that the CT-based treatment planning system of TBI can calculate prescription MU within an acceptable tolerance.
authors: Department of Radiology, Shiga Medical Center for Children.
authors: Atsushi
authors: A
authors: Fukuda
mesh_terms: D006801:Humans; D010347:Patient Care Planning; D019047:Phantoms, Imaging; D011874:Radiometry; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D012867:Skin; D014916:Whole-Body Irradiation