title: Rare-earth-catalyzed C-H bond addition of pyridines to olefins.
abstract: An efficient and general protocol for the ortho-alkylation of pyridines via C-H addition to olefins has been developed, using cationic half-sandwich rare-earth catalysts, which provides an atom-economical method for the synthesis of alkylated pyridine derivatives. A wide range of pyridine and olefin substrates including α-olefins, styrenes, and conjugated dienes are compatible with the catalysts.
authors: Organometallic Chemistry Laboratory and Advanced Catalyst Research Team, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
authors: Bing-Tao
authors: BT
authors: Guan
authors: Zhaomin
authors: Z
authors: Hou
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D008674:Metals, Rare Earth / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D008674:Metals, Rare Earth; D009942:Organometallic Compounds; D011725:Pyridines