title: Pico-inplace-inversions between human and chimpanzee.
abstract: BACKGROUND
  There have been several studies on the micro-inversions between human and chimpanzee, but there are large discrepancies among their results. Furthermore, all of them rely on alignment procedures or existing alignment results to identify inversions. However, the core alignment procedures do not take very small inversions into consideration. Therefore, their analyses cannot find inversions that are too small to be detected by a classic aligner. We call such inversions pico-inversions.
  
  
  RESULTS
  We re-analyzed human-chimpanzee alignment from the UCSC Genome Browser for micro-inplace-inversions and screened for pico-inplace-inversions using a likelihood ratio test. We report that the quantity of inplace-inversions between human and chimpanzee is substantially greater than what had previously been discovered. We also present the software tool PicoInversionMiner to detect pico-inplace-inversions between closely related species.
  
  
  BACKGROUND
  Software tools, scripts and result data are available at http://faculty.cs.niu.edu/~hou/PicoInversion.html.
  
  
  BACKGROUND
  mhou@cs.niu.edu.
authors: Department of Computer Science, Northern Illinois University, DeKalb, IL 60115, USA. mhou@cs.niu.edu
authors: Minmei
authors: M
authors: Hou
authors: Ping
authors: P
authors: Yao
authors: Angela
authors: A
authors: Antonou
authors: Mitrick A
authors: MA
authors: Johns
mesh_terms: D000818:Animals; D007446:Chromosome Inversion; D019143:Evolution, Molecular; D016678:Genome; D006801:Humans; D002679:Pan troglodytes / Q000235:genetics*; D016415:Sequence Alignment / Q000379:methods*; D012984:Software