title: Progress toward developing a carbohydrate-conjugate vaccine against Clostridium difficile ribotype 027: synthesis of the cell-surface polysaccharide PS-I repeating unit.
abstract: Clostridium difficile strain ribotype 027 is a hypervirulent pathogen that is responsible for recent, severe outbreaks of serious nosocomial infections. As a foundation for the development of a preventative carbohydrate-based vaccine, we have synthesized a pentasaccharide cell wall repeating unit from PS-I unique to this strain, by the linear assembly of four monosaccharide building blocks.
authors: Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Am Mühlenberg 1, 14476 Potsdam, Germany.
authors: Christopher E
authors: CE
authors: Martin
authors: Markus W
authors: MW
authors: Weishaupt
authors: Peter H
authors: PH
authors: Seeberger
mesh_terms: D002240:Carbohydrate Sequence; D002473:Cell Wall / Q000737:chemistry; D016360:Clostridioides difficile / Q000166:cytology* / Q000276:immunology*; D015195:Drug Design; D008969:Molecular Sequence Data; D011135:Polysaccharides, Bacterial / Q000138:chemical synthesis* / Q000737:chemistry* / Q000276:immunology; D018074:Vaccines, Conjugate / Q000737:chemistry / Q000276:immunology
chemical_list: D011135:Polysaccharides, Bacterial; D018074:Vaccines, Conjugate