title: Prothrombotic gene variants and mortality after cerebral ischemia of arterial origin.
abstract: BACKGROUND
  Several functional prothrombotic gene variants have been associated with cerebral ischemia and myocardial infarction. We hypothesized that such gene variants may also be associated with mortality after cerebral ischemia of arterial origin because of an increased risk of fatal vascular events.
  
  
  METHODS
  We performed a case-control study in 316 long-term survivors and 887 patients with recent cerebral ischemia of arterial origin. False discovery rate q values were calculated to account for multiple testing. The mean duration between occurrence of cerebral ischemia and DNA collection was 16.8 years in long-term survivors and 3.2 months in recent patients.
  
  
  RESULTS
  Two of 23 variants were associated with mortality: the 95Arg allele of the coagulation factor XIII subunit B (F13B) His95Arg variant (OR, 1.5 for Arg/Arg and His/Arg vs. His/His genotype; 95% CI, 1.1-2.2, q = 0.29) and the 4G allele of the plasminogen activator inhibitor-1 (PAI-1) 4G/5G variant (OR, 1.5 for 4G/4G and 5G/4G vs. 5G/5G genotype; 95% CI, 1.1-2.0, q = 0.29). Both associations disappeared after accounting for multiple testing. Data analysis restricted to recently deceased patients (n = 133) yielded similar results.
  
  
  CONCLUSIONS
  In this hospital-based study none of 23 prothrombotic gene variants were associated with long-term mortality after cerebral ischemia of arterial origin. Prothrombotic gene variants do not appear to play an important role in long-term mortality after cerebral ischemia.
authors: Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.
authors: D Martijn O
authors: DM
authors: Pruissen
authors: Frits R
authors: FR
authors: Rosendaal
authors: Catharina J M
authors: CJ
authors: Frijns
authors: L Jaap
authors: LJ
authors: Kappelle
authors: Hans L
authors: HL
authors: Vos
authors: Ale
authors: A
authors: Algra
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000235:genetics* / Q000401:mortality*; D016022:Case-Control Studies; D002536:Cerebral Arteries / Q000473:pathology; D005176:Factor XIII / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D005176:Factor XIII; C054380:factor XIIIb