title: 4-Week inhalation toxicity of 2-methylnaphthalene in experimental animals.
abstract: OBJECTIVE
  This paper presents toxic effects of 2-MN in laboratory animals under conditions of 4-week inhalation exposure to 2-methylnaphthalene (2-MN) vapors.
  
  
  METHODS
  Male Wistar rats were exposed to 2-MN vapors at a nominal concentration of 0, 2, 10 or 50 mg/m(3) in dynamic inhalation chambers for 4 weeks (6 h/day, 5 days/week). After 4 weeks of inhalation exposure the animals were necropsied. Blood samples were collected and selected organs were weighted and prepared for histological examinations.
  
  
  RESULTS
  The effects of the increased levels of exposure to 2-MN experienced by the experimental rats were as follows: a) increasing γ-glutamylotransferase activity, b) stimulation of the hematopoietic system, c) lower cholesterol concentrations, d) higher number of goblet cells in lobar bronchi, e) hyperplasia of hepatic bile ducts.
  
  
  CONCLUSIONS
  Four-week exposure of the animals to 2-MN at 2 mg/m(3) proved to be the no-observed-adverse-effect-level (NOAEL), while 10 mg/m(3) appeared to represent the lowest-observed-adverse-effect-level (LOAEL).
authors: Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Łódź, Poland. radek@imp.lodz.pl
authors: Radosław
authors: R
authors: Swiercz
authors: Wojciech
authors: W
authors: Wąsowicz
authors: Jan
authors: J
authors: Stetkiewicz
authors: Jolanta
authors: J
authors: Gromadzińska
authors: Wanda
authors: W
authors: Majcherek
mesh_terms: D000825:Animal Structures / Q000187:drug effects / Q000473:pathology; D000818:Animals; D005260:Female; D019570:Inhalation Exposure / Q000009:adverse effects*; D008297:Male; D009281:Naphthalenes / Q000097:blood / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D009281:Naphthalenes; C027384:2-methylnaphthalene