title: The adaptor proteins p140CAP and p130CAS as molecular hubs in cell migration and invasion of cancer cells.
abstract: The assembly of molecular hubs upon integrin and growth factor stimulation represents a preferential way to transduce signals throughout the cell. Among the intracellular kinases that are responsive to integrin and growth factor activation, Src Family Kinases (SFKs) are crucial regulators of cell migration and invasion. Increasing evidence highlight the importance of adaptor proteins in these processes, based on their ability to create signalling platforms that control downstream signals. Among these adaptors we will discuss the molecular features of p130Cas and p140Cap proteins in terms of regulation of cell migration and invasion in normal and transformed cells.
authors: Molecular Biotechnology Center, Università di Torino Via Nizza 52, Torino, Italy.
authors: Paola
authors: P
authors: Di Stefano
authors: Maria Pilar Camacho
authors: MP
authors: Leal
authors: Giusy
authors: G
authors: Tornillo
authors: Brigitte
authors: B
authors: Bisaro
authors: Daniele
authors: D
authors: Repetto
authors: Alessandra
authors: A
authors: Pincini
authors: Emanuela
authors: E
authors: Santopietro
authors: Nanaocha
authors: N
authors: Sharma
authors: Emilia
authors: E
authors: Turco
authors: Sara
authors: S
authors: Cabodi
authors: Paola
authors: P
authors: Defilippi