title: Association of ApoE genetic polymorphisms with proximal deep venous thrombosis.
abstract: The aim of the current study was to evaluate a possible association between apolipoprotein E (ApoE) genetic polymorphisms and deep venous thrombosis. A case-control study of ApoE genetic polymorphisms was carried out in 60 male and female patients with deep venous thrombosis and 60 male and female controls. The ages of the patients ranged between 23 and 90 years old (mean ± standard deviation: 58 ± 16.56 years) and the ages of the control group, varied between 21 and 56 years old (mean ± SD: 33 ± 10.93 years). Genetic polymorphisms were analyzed in respect to the prevalence of alleles (APOE*2, APOE*3 and APOE*4) and genotypes (APOE*2/2, APOE*2/3, APOE*2/4, APOE*3/3, APOE*3/4 and APOE*4/4). The ε2 allele was more common in patients who had suffered thrombotic events (P = 0.0034). Additionally, there was a significant difference on comparing the distribution of alleles in female patients and female controls (P = 0.027). These results demonstrate an association between the ApoE ε2 allele and deep venous thrombotic events in women. This association opens the possibility of a new line of research to better understand these thrombotic events.
authors: Department of Cardiology and Cardiovascular Surgery, Medicine School in São José do Rio Preto (FAMERP), São Paulo, Brazil.
authors: Luís Cavalcante
authors: LC
authors: Nagato
authors: Marcela Augusta
authors: MA
authors: de Souza Pinhel
authors: José Maria Pereira
authors: JM
authors: de Godoy
authors: Dorotéia Rossi Silva
authors: DR
authors: Souza
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D053329:Apolipoprotein E2 / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012737:Sex Factors; D020246:Venous Thrombosis / Q000175:diagnosis / Q000235:genetics*; D055815:Young Adult
chemical_list: D053329:Apolipoprotein E2