title: Survey of anaemia and Helicobacter pylori infection in adolescent girls in Suihua, China and enhancement of iron intervention effects by H. pylori eradication.
abstract: In the present study, we investigated the prevalence of anaemia and Fe deficiency anaemia (IDA) and explored the relationship between Helicobacter pylori infection and IDA in adolescent girls. A total of 1037 adolescent girls from Suihua, China were enrolled. Hb, serum ferritin (SF), serum transferrin receptor (sTfR) and serum IgG antibodies to H. pylori were measured. Participants with IDA and co-existing H. pylori infection (n 80) who had an intake of >25 mg/d of Fe were assigned randomly to the intervention and control groups. Patients in the intervention group were administered a 12-week course of oral EDTA-Na-Fe (60 mg Fe/dose, three times a week) and a 2-week course of colloidal bismuth subcitrate, amoxicillin and metronidazole. Subjects in the control group were administered EDTA-Na-Fe alone. Hb, SF and sTfR were reassessed 3 months after the 12-week regimen ended. Prevalence of anaemia, Fe deficiency (defined as SF < 12·0 μg/l), IDA and H. pylori infection in the population of 1037 was 19.5, 40.4, 17.1 and 31.2 %, respectively. The prevalence of H. pylori infection in the IDA group was 46.9 %, while the non-anaemic group had 28.1 % prevalence. A significant increase in Hb and SF and a decrease in sTfR value were found in the intervention group and the H. pylori-negative group. Findings suggest that IDA is still one of the prominent problems in adolescent girls. There is an association between H. pylori infection and IDA. Treatment of H. pylori infection is associated with a more rapid response to oral Fe therapy.
authors: Department of Children Health and Hygiene, School of Public Health, Harbin Medical University, Harbin, Heilongjiang Province, People's Republic of China.
authors: Wei
authors: W
authors: Xia
authors: Xin
authors: X
authors: Zhang
authors: Jiajia
authors: J
authors: Wang
authors: Caihong
authors: C
authors: Sun
authors: Lijie
authors: L
authors: Wu
mesh_terms: D000293:Adolescent; D000658:Amoxicillin / Q000627:therapeutic use; D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000150:complications / Q000178:diet therapy / Q000453:epidemiology* / Q000208:ethnology; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000032:analysis; D002648:Child; D002681:China / Q000453:epidemiology; D019587:Dietary Supplements; D004359:Drug Therapy, Combination; D004492:Edetic Acid / Q000627:therapeutic use; D005260:Female; D005290:Ferric Compounds / Q000627:therapeutic use; D005500:Follow-Up Studies; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D008403:Mass Screening; D008795:Metronidazole / Q000627:therapeutic use; D009942:Organometallic Compounds / Q000627:therapeutic use; D015995:Prevalence; D018881:Suburban Health / Q000208:ethnology; D014504:Urban Health / Q000208:ethnology
chemical_list: D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D000907:Antibodies, Bacterial; D005290:Ferric Compounds; D009942:Organometallic Compounds; D008795:Metronidazole; D000658:Amoxicillin; D004492:Edetic Acid; C002791:bismuth tripotassium dicitrate; C019179:Fe(III)-EDTA