title: Quality of RCTs exploring Helicobacter pylori eradication for the prevention of gastric cancer and preneoplastic lesions.
abstract: Randomized controlled trials (RCTs) are considered the gold standard for evaluating the efficacy of clinical interventions and developing evidence-based clinical practice guidelines; however, they can yield biased results when their methodology is less than rigorous, or their published reports fail to report key items. A number of RCTs have been carried out to explore the relationship between Helicobacter pylori eradication and gastric cancer, but their results remain controversial. In this article, we will comprehensively review searched medical electronic databases, and appraise the reporting and methodological quality of these relevant RCTs according to the Consolidated Standards of Reporting Trials 2010 statement and the Cochrane Handbook in order to learn about the internal and external validity of these RCTs.
authors: Shanghai Institute of Digestive Disease, Shanghai Jiao-Tong University School of Medicine, Ren-ji Hospital, 145 Shandong Rd Middle, Shanghai 200001, China.
authors: Tian-Tian
authors: TT
authors: Sun
authors: Ji-Lin
authors: JL
authors: Wang
authors: Jing-Yuan
authors: JY
authors: Fang
mesh_terms: D016481:Helicobacter Infections / Q000517:prevention & control*; D016480:Helicobacter pylori; D006801:Humans; D015201:Meta-Analysis as Topic; D011230:Precancerous Conditions / Q000382:microbiology / Q000517:prevention & control; D016032:Randomized Controlled Trials as Topic / Q000379:methods* / Q000592:standards*; D015203:Reproducibility of Results; D013274:Stomach Neoplasms / Q000382:microbiology* / Q000517:prevention & control*