title: New insights into the mechanism of low high-density lipoprotein cholesterol in obesity.
abstract: Obesity, a significant risk factor for various chronic diseases, is universally related to dyslipidemia mainly represented by decreasing high-density lipoprotein cholesterol (HDL-C), which plays an indispensible role in development of cardiovascular disease (CVD). However, the mechanisms underlying obesity and low HDL-C have not been fully elucidated. Previous studies have focused on the alteration of HDL catabolism in circulation following elevated triglyceride (TG). But recent findings suggested that liver and fat tissue played pivotal role in obesity related low HDL-C. Some new molecular pathways like microRNA have also been proposed in the regulation of HDL metabolism in obesity. This article will review recent advances in understanding of the potential mechanism of low HDL-C in obesity.
authors: Departments of Cardiology, the Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, PR China.
authors: Hao
authors: H
authors: Wang
authors: Dao-Quan
authors: DQ
authors: Peng
mesh_terms: D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters / Q000378:metabolism; D017667:Adipocytes / Q000378:metabolism; D000818:Animals; D002318:Cardiovascular Diseases / Q000209:etiology; D002784:Cholesterol / Q000378:metabolism; D008078:Cholesterol, LDL / Q000097:blood / Q000378:metabolism*; D050171:Dyslipidemias / Q000209:etiology; D022781:Hepatocytes / Q000378:metabolism; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood / Q000378:metabolism; D035683:MicroRNAs / Q000378:metabolism; D009765:Obesity / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology; D051780:Sterol Regulatory Element Binding Protein 1 / Q000378:metabolism
chemical_list: D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters; D008078:Cholesterol, LDL; D008075:Lipoproteins, HDL; C550416:MIRN33a microRNA, human; D035683:MicroRNAs; D051780:Sterol Regulatory Element Binding Protein 1; D002784:Cholesterol