title: Parathyroid hormone/parathyroid hormone-related peptide receptor 1 expression in odontogenic cystic lesions.
abstract: OBJECTIVE
  To evaluate parathyroid hormone/parathyroid hormone-related peptide receptor 1 (PTHR1) expression in odontogenic cystic lesions and to compare immunoexpression between the lesions.
  
  
  METHODS
  Thirty-five radicular cysts, 22 dentigerous cysts and 17 keratocystic odontogenic tumours were evaluated. Immunohistochemical reactions against PHTR1 were carried out in 3-μm histological sections, and the expression and the intensity of PTHR1 expression were evaluated. For statistical analysis, the Fisher exact test was used, with a significance of 5%.
  
  
  RESULTS
  The intensity of expression in the epithelial lining was significantly weaker in the radicular cyst (P = 0.007). However, in the fibrous capsule, the radicular cyst presented higher positivity for PTHR1 (P = 0.04).
  
  
  CONCLUSIONS
  The probable co-expression of PTHrP and PTHR1 in odontogenic cystic lesions may eventually have an autocrine and/or paracrine stimulus in the epithelial and mesenchymal cells, inducing proliferation and lesion growth.
authors: School of Dentistry, University of Ribeirao Preto (UNAERP), Ribeirao Preto, Sao Paulo Department of Stomatology, A. C. Camargo Hospital, Sao Paulo.
authors: A C
authors: AC
authors: Lima
authors: E R
authors: ER
authors: Fregnani
authors: Y T C
authors: YT
authors: Silva-Sousa
authors: D E
authors: DE
authors: da Cruz Perez
mesh_terms: D002863:Chromogenic Compounds; D003803:Dentigerous Cyst / Q000473:pathology; D042783:Endothelial Cells / Q000473:pathology; D004847:Epithelial Cells / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D005347:Fibroblasts / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008648:Mesoderm / Q000473:pathology; D009807:Odontogenic Cysts / Q000473:pathology*; D009808:Odontogenic Tumors / Q000473:pathology; D010281:Parathyroid Hormone / Q000032:analysis*; D011842:Radicular Cyst / Q000473:pathology; D044168:Receptor, Parathyroid Hormone, Type 1 / Q000032:analysis*
chemical_list: D002863:Chromogenic Compounds; D010281:Parathyroid Hormone; D044168:Receptor, Parathyroid Hormone, Type 1