title: Coenzyme Q(10) supplementation ameliorates inflammatory signaling and oxidative stress associated with strenuous exercise.
abstract: BACKGROUND
  Exhausting exercise induces muscle damage associated with high production of free radicals and pro-inflammatory mediators.
  
  
  OBJECTIVE
  The objective of this study was to determine for the first time and simultaneously whether oral coenzyme Q(10) (CoQ(10)) supplementation can prevent over-expression of inflammatory mediators and oxidative stress associated with strenuous exercise.
  
  
  METHODS
  The participants were classified in two groups: CoQ(10) group (CG) and placebo group (PG). The physical test consisted in a constant run (50 km) that combined several degrees of high effort (mountain run and ultra-endurance), in permanent climbing.
  
  
  RESULTS
  Exercise was associated with an increase in TNF-α, IL-6, 8-hydroxy-2'-deoxyguanosine (8-OHdG), and isoprostane levels, revealing the degree of inflammation and oxidative stress induced. Oral supplementation of CoQ(10) during exercise was efficient reducing oxidative stress (decreased membrane hydroperoxides, 8-OHdG and isoprostanes generation, increased catalase, and total antioxidant status), which would lead to the maintenance of the cell integrity. Data obtained also indicate that CoQ(10) prevents over-expression of TNF-α after exercise, together with an increase in sTNF-RII that limits the pro-inflammatory actions of TNF. Moreover, CoQ(10) supplementation reduced creatinine production.
  
  
  CONCLUSIONS
  CoQ(10) supplementation before strenuous exercise decreases the oxidative stress and modulates the inflammatory signaling, reducing the subsequent muscle damage.
authors: Department of Physiology, University of Granada, Granada, Spain.
authors: Javier
authors: J
authors: Díaz-Castro
authors: Rafael
authors: R
authors: Guisado
authors: Naroa
authors: N
authors: Kajarabille
authors: Carmen
authors: C
authors: García
authors: Isabel M
authors: IM
authors: Guisado
authors: Carlos
authors: C
authors: de Teresa
authors: Julio J
authors: JJ
authors: Ochoa
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000284:Administration, Oral; D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D056352:Athletes; D002374:Catalase / Q000378:metabolism; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000097:blood; D019587:Dietary Supplements; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D018836:Inflammation Mediators / Q000037:antagonists & inhibitors / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood; D028421:Isoprostanes / Q000097:blood; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D012420:Running / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D000975:Antioxidants; D018836:Inflammation Mediators; D015850:Interleukin-6; D028421:Isoprostanes; D014409:Tumor Necrosis Factor-alpha; D014451:Ubiquinone; D000080242:8-Hydroxy-2'-Deoxyguanosine; D002374:Catalase; C024989:coenzyme Q10; D003849:Deoxyguanosine