title: AMPA receptor endocytosis in rat perirhinal cortex underlies retrieval of object memory.
abstract: Mechanisms consistent with long-term depression in the perirhinal cortex (PRh) play a fundamental role in object recognition memory; however, whether AMPA receptor endocytosis is involved in distinct phases of recognition memory is not known. To address this question, we used local PRh infusions of the cell membrane-permeable Tat-GluA2(3Y) interference peptide or a scrambled control to block the endocytosis of AMPA receptors during the encoding, consolidation, or retrieval phase of object recognition memory. Tat-GluA2(3Y) infusion before the encoding and consolidation phases did not alter recognition memory. In contrast, Tat-GluA2(3Y) infusion prior to the retrieval phase disrupted object recognition memory. The present results indicate a distinct role for AMPA receptor endocytosis in the retrieval of visual recognition memory.
authors: Department of Physiology, University of Saskatchewan, Saskatoon, SK, Canada.
authors: Brittany N
authors: BN
authors: Cazakoff
authors: John G
authors: JG
authors: Howland
mesh_terms: D000818:Animals; D004705:Endocytosis / Q000502:physiology*; D036881:Long-Term Synaptic Depression / Q000502:physiology*; D008297:Male; D011939:Mental Recall / Q000502:physiology; D010775:Photic Stimulation; D051381:Rats; D020318:Rats, Long-Evans; D018091:Receptors, AMPA / Q000378:metabolism*; D021641:Recognition, Psychology / Q000502:physiology*; D018709:Statistics, Nonparametric; D013702:Temporal Lobe / Q000378:metabolism*; D014796:Visual Perception / Q000502:physiology
chemical_list: D018091:Receptors, AMPA