title: Comparison of permissible source region and multispectral data using efficient bioluminescence tomography method.
abstract: As a novel molecular imaging technology, bioluminescence tomography (BLT) has become an important tool for biomedical research in recent years, which can perform a quantitative reconstruction of an internal light source distribution with the scattered and transmitted bioluminescent signals measured on the external surface of a small animal. However, BLT is severely ill-posed because of complex photon propagation in the biological tissue and limited boundary measured data with noise. Therefore, sufficient a priori knowledge should be fused for the uniqueness and stability of BLT solution. Permissible source region strategy and spectrally resolved measurements are two kinds of a priori knowledge commonly used in BLT reconstruction. This paper compares their performance with simulation and in vivo heterogeneous mouse experiments. In order to improve the efficiency of large-scale source restoration, this paper introduces an efficient iterative shrinkage thresholding method that not only has faster convergence rate but also has better reconstruction accuracy than the modified Newton-type optimization approach. Finally, a discussion of these two kinds of a priori knowledge is given based on the comparison results.
authors: Intelligent Medical Research Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
authors: Chenghu
authors: C
authors: Qin
authors: Shouping
authors: S
authors: Zhu
authors: Jinchao
authors: J
authors: Feng
authors: Jianghong
authors: J
authors: Zhong
authors: Xibo
authors: X
authors: Ma
authors: Ping
authors: P
authors: Wu
authors: Jie
authors: J
authors: Tian
mesh_terms: D000465:Algorithms; D000825:Animal Structures / Q000033:anatomy & histology; D000818:Animals; D003198:Computer Simulation; D003287:Contrast Media / Q000008:administration & dosage; D005456:Fluorescent Dyes / Q000008:administration & dosage; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008163:Luminescent Measurements / Q000295:instrumentation / Q000379:methods*; D051379:Mice; D008819:Mice, Nude; D057054:Molecular Imaging / Q000295:instrumentation / Q000379:methods; D055620:Optical Phenomena; D019047:Phantoms, Imaging; D014054:Tomography / Q000295:instrumentation / Q000379:methods*; D055114:X-Ray Microtomography
chemical_list: D003287:Contrast Media; D005456:Fluorescent Dyes