title: Sleep-prolonging effect of Coriandrum sativum hydro-alcoholic extract in mice.
abstract: The present study was planned to investigate sleep-prolonging effect of C. sativum. The hydro-alcoholic extract (HAE) and its three fractions namely water (WF), ethyl acetate (EAF) and N-butanol (NBF) were prepared from C. sativum aerial parts and administrated to mice. Also, the possible cytotoxicity of the extracts was tested using cultured PC12 cells. The HAE, EAF and NBF significantly prolonged sleep duration. Only the NBF could significantly decrease sleep latency. No decrease in the neuronal surviving was observed either by HAE or by its fractions. The present data indicate that C. sativum exert sleep-prolonging action without major neurotoxic effect.
authors: Pharmacological Research Center of Medicinal Plants, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors: Hassan
authors: H
authors: Rakhshandeh
authors: Hamid Reza
authors: HR
authors: Sadeghnia
authors: Ahmad
authors: A
authors: Ghorbani
mesh_terms: D020001:1-Butanol / Q000737:chemistry; D000085:Acetates / Q000737:chemistry; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D028526:Coriandrum / Q000737:chemistry*; D006993:Hypnotics and Sedatives / Q000009:adverse effects / Q000737:chemistry* / Q000494:pharmacology*; D051379:Mice; D016716:PC12 Cells; D010424:Pentobarbital / Q000494:pharmacology; D010936:Plant Extracts / Q000009:adverse effects / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D012890:Sleep / Q000187:drug effects*
chemical_list: D000085:Acetates; D006993:Hypnotics and Sedatives; D010936:Plant Extracts; C007650:ethyl acetate; D020001:1-Butanol; D010424:Pentobarbital