title: Sirolimus- vs. paclitaxel-eluting stent to coronary intervention in dialysis patients.
abstract: BACKGROUND
  Patients on maintenance hemodialysis (HD) are at high risk for restenosis after percutaneous coronary intervention (PCI) even if treated with a sirolimus-eluting stent (SES). The aim of this study was to compare the effects of SES and paclitaxel-eluting stent (PES) in preventing restenosis in HD patients with coronary artery disease.
  
  
  METHODS
  A total of 100 consecutive patients on HD who underwent PCI were enrolled into the study. They were randomly assigned to receive either SES or PES. We compared follow-up angiographic outcomes between the SES and PES groups at 8-month follow-up.
  
  
  RESULTS
  The angiographical restenosis rate, defined as % diameter stenosis>50% at 8-month follow-up, was 19.7% in the SES group and 20.0% in the PES group (p=0.97). Late loss was also similar between the two groups (0.49±0.70 mm vs. 0.48±0.91 mm, P=0.94). There were no significant differences in the rates of all-cause death, non-fatal myocardial infarction, or TLR due to stent restenosis-induced ischemia between the two groups (2.0% vs. 4.0%, p=0.56, 2.0% vs. 4.0%, p=0.56, and 16.0% vs. 12.0%, p=0.57, respectively).
  
  
  CONCLUSIONS
  There was no significant difference in angiographical outcome at 8-month follow-up between HD patients treated with SES and PES. Even if treated with DES including SES and PES, patients on HD are at high risk of restenosis after PCI.
authors: Department of Cardiology, Nagoya Kyoritsu Hospital, Nagoya, Japan.
authors: Daisuke
authors: D
authors: Kamoi
authors: Hideki
authors: H
authors: Ishii
authors: Hiroshi
authors: H
authors: Takahashi
authors: Toru
authors: T
authors: Aoyama
authors: Takanobu
authors: T
authors: Toriyama
authors: Miho
authors: M
authors: Tanaka
authors: Yoshihiro
authors: Y
authors: Kawamura
authors: Kazuhiro
authors: K
authors: Kawashima
authors: Daiji
authors: D
authors: Yoshikawa
authors: Tetsuya
authors: T
authors: Amano
authors: Tadayuki
authors: T
authors: Uetani
authors: Tatsuaki
authors: T
authors: Matsubara
authors: Toyoaki
authors: T
authors: Murohara
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000628:therapy*; D054855:Drug-Eluting Stents; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage*; D062645:Percutaneous Coronary Intervention / Q000379:methods; D011446:Prospective Studies; D011859:Radiography; D006435:Renal Dialysis / Q000009:adverse effects; D020123:Sirolimus / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D017239:Paclitaxel; D020123:Sirolimus