title: Cardiac cycle-related volume change in unruptured cerebral aneurysms: a detailed volume quantification study using 4-dimensional CT angiography.
abstract: OBJECTIVE
  The hemodynamic factors of aneurysms were recently evaluated using computational fluid dynamics in a static vessel model in an effort to understand the mechanisms of initiation and rupture of aneurysms. However, few reports have evaluated the dynamic wall motion of aneurysms due to the cardiac cycle. The objective of this study was to quantify cardiac cycle-related volume changes in aneurysms using 4-dimensional CT angiography.
  
  
  METHODS
  Four-dimensional CT angiography was performed in 18 patients. Image data of 1 cardiac cycle were divided into 10 phases and the volume of the aneurysm was then quantified in each phase. These data were also compared with intracranial vessels of normal appearance.
  
  
  RESULTS
  The observed cardiac cycle-related volume changes were in good agreement with the sizes of the aneurysms and normal vessels. The cardiac cycle-related volume changes of the intracranial aneurysms and intracranial normal arteries were 5.40%±4.17% and 4.20±2.04%, respectively, but these did not differ statistically (P=0.12).
  
  
  CONCLUSIONS
  We successfully quantified the volume change in intracranial aneurysms and intracranial normal arteries in human subjects. The data may indicate that cardiac cycle-related volume changes do not differ between unruptured aneurysms and normal intracranial arteries, suggesting that the global integrity of an unruptured aneurysmal wall is not different from that of normal intracranial arteries.
authors: Department of Neurosurgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors: Junko
authors: J
authors: Kuroda
authors: Manabu
authors: M
authors: Kinoshita
authors: Hisashi
authors: H
authors: Tanaka
authors: Takeo
authors: T
authors: Nishida
authors: Hajime
authors: H
authors: Nakamura
authors: Yoshiyuki
authors: Y
authors: Watanabe
authors: Noriyuki
authors: N
authors: Tomiyama
authors: Toshiyuki
authors: T
authors: Fujinaka
authors: Toshiki
authors: T
authors: Yoshimine
mesh_terms: D000368:Aged; D002306:Cardiac Volume; D002533:Cerebral Angiography; D005260:Female; D056973:Four-Dimensional Computed Tomography; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged