title: A 4-week Repeated Dose Oral Toxicity and Cytotoxicity Study of Gumiganghwaltang in Crl:CD (SD) Rats.
abstract: Gumiganghwaltang (GGT) is a traditional oriental herbal prescription commonly used to treat colds and inflammatory diseases in Korea. This study reports the first evaluation of the oral toxicity and cytotoxicity effects of repeat doses of GGT. GGT was orally administered daily at doses of 0, 500, 1000, and 2000 mg/kg for 4 weeks. Analysis of body weight gain, mortality, clinical observations, urinalysis, blood biochemistry, hematology, organ weight, and histopathological data revealed no significant differences between the V.CONTROL and GGT-treated groups. In addition, we investigated the cytotoxicity of GGT against LNCaP, RBL-1, and BEAS-2B cell lines, and splenocytes. Based on the results, we conclude that GGT orally administered to rats is safe with no drug-related toxicity, even at the highest dose, in 4-week repeated dose studies. Thus, this concentration is considered the non-observable effect dose in rats.
authors: Depatment of Herbal Medicine EBM Research Center, Korea Institute of Oriental Medicine, Yuseong-gu, Daejeon 305 811, Korea.
authors: Mee-Young
authors: MY
authors: Lee
authors: In-Sik
authors: IS
authors: Shin
authors: Chang-Seob
authors: CS
authors: Seo
authors: Jung-Hoon
authors: JH
authors: Kim
authors: Heykyung
authors: H
authors: Ha
authors: Jung-Im
authors: JI
authors: Huh
authors: Hyeun-Kyoo
authors: HK
authors: Shin