title: Autophagy and p62 in cardiac protein quality control.
abstract: This is an addendum to a recent report which demonstrates for the first time that autophagic flux is increased in the heart of a well-established mouse model of cardiac proteinopathy and p62 is transcriptionally upregulated in cardiomyocytes and hearts overexpressing human cardiomyopathy-linked misfolded proteins. The p62 plays a critical and protective role in aggresome formation and autophagic activation in cardiomyocytes overexpressing misfolded proteins.
authors: Protein Quality Control and Degradation Research Center, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA.
authors: Huabo
authors: H
authors: Su
authors: Xuejun
authors: X
authors: Wang
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D001343:Autophagy; D006801:Humans; D008247:Lysosomes / Q000378:metabolism / Q000648:ultrastructure; D051379:Mice; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D032383:Myocytes, Cardiac / Q000378:metabolism; D010588:Phagosomes / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing