title: Antiretroviral therapy for treatment-naïve chronic HIV-1 infection with an axonal variant of Guillain-Barré syndrome positive for anti-ganglioside antibody: a case report.
abstract: Guillain-Barré syndrome sometimes manifests as immune reconstitution inflammatory syndrome. We report a treatment-naïve male with chronic HIV-1 infection who presented with an axonal variant of Guillain-Barré syndrome. Antiretroviral therapy commenced one month later and no rapid improvement or deterioration of tetraparesis was noted. This is the first report that describes the detection and serial measurements of anti-ganglioside antibody in a patient with HIV infection. This case suggests a limited role for T-cell immunity in the production of anti-ganglioside antibody and the pathogenesis of axonal variants, since the antiretroviral therapy-induced improvement in T-cell immunity neither re-elevated anti-ganglioside antibody titer nor worsened tetraparesis.
authors: National Center for Global Health and Medicine, Japan. tnishiji@acc.ncgm.go.jp
authors: Takeshi
authors: T
authors: Nishijima
authors: Kunihisa
authors: K
authors: Tsukada
authors: Sosuke
authors: S
authors: Takeuchi
authors: Atsuro
authors: A
authors: Chiba
authors: Miwako
authors: M
authors: Honda
authors: Katsuji
authors: K
authors: Teruya
authors: Hiroyuki
authors: H
authors: Gatanaga
authors: Yoshimi
authors: Y
authors: Kikuchi
authors: Shinichi
authors: S
authors: Oka
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D005677:G(M1) Ganglioside / Q000276:immunology*; D020275:Guillain-Barre Syndrome / Q000097:blood* / Q000145:classification / Q000150:complications*; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D015497:HIV-1; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male
chemical_list: D044966:Anti-Retroviral Agents; D007074:Immunoglobulin G; D005677:G(M1) Ganglioside