title: Personal and family history of immune-related conditions increase the risk of plasma cell disorders: a population-based study.
abstract: The associations between immune-related conditions and multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) have previously been investigated with inconsistent results. In a large population-based study, we identified 19 112 patients with MM, 5403 patients with MGUS, 96 617 matched control subjects, and 262 931 first-degree relatives. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) for the association of MM and MGUS with immune-related conditions by use of logistic regression. A personal history of all infections combined was associated with a significantly increased risk of MM (OR = 1.2; 95% CI, 1.1-1.3), and a personal history of all conditions in the categories infections (OR = 1.6; 95% CI, 1.5-1.7), inflammatory conditions (OR = 1.4; 95% CI, 1.2-1.5), and autoimmune diseases (OR = 2.1; 95% CI, 1.9-2.4) was associated with a significantly increased risk of MGUS. Several specific immune-related conditions elevated the risk of MM and/or MGUS. A family history of autoimmune disease was associated with a significantly increased risk of MGUS (OR = 1.1; 95% CI, 1.00-1.2), but not MM. Our findings suggest that immune-related conditions and/or their treatment are of importance in the etiology of MGUS and possibly MM. The association of both personal and family history of autoimmune disease with MGUS indicates the potential for shared susceptibility for these conditions.
authors: Department of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden.
authors: Ebba K
authors: EK
authors: Lindqvist
authors: Lynn R
authors: LR
authors: Goldin
authors: Ola
authors: O
authors: Landgren
authors: Cecilie
authors: C
authors: Blimark
authors: Ulf-Henrik
authors: UH
authors: Mellqvist
authors: Ingemar
authors: I
authors: Turesson
authors: Anders
authors: A
authors: Wahlin
authors: Magnus
authors: M
authors: Björkholm
authors: Sigurdur Y
authors: SY
authors: Kristinsson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001327:Autoimmune Diseases / Q000276:immunology* / Q000503:physiopathology; D016022:Case-Control Studies; D015331:Cohort Studies; D004198:Disease Susceptibility / Q000276:immunology; D005192:Family Health; D005260:Female; D006801:Humans; D007154:Immune System Diseases / Q000503:physiopathology*; D007239:Infections / Q000503:physiopathology; D007249:Inflammation / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000453:epidemiology / Q000209:etiology / Q000276:immunology*; D009101:Multiple Myeloma / Q000453:epidemiology / Q000209:etiology / Q000276:immunology; D012042:Registries; D012306:Risk; D013548:Sweden / Q000453:epidemiology; D055815:Young Adult