title: Current surgical treatment of non-small-cell lung cancer.
abstract: When considering surgical treatment for non-small-cell lung cancer (NSCLC), a distinction is made between early-stage disease (stages IA/B and IIA/B), locoregionally advanced disease (stages IIIA/B) and metastatic disease (stage IV). Complete surgical resection of NSCLC can provide good long-term outcome. Surgery is considered the treatment of choice in patients with early-stage NSCLC or patients with T3N1 disease. Surgery for locoregionally advanced disease remains controversial. In specific cases of T4 disease, surgery can provide long-term survival. In patients with stage IIIA-N2 disease, surgery is only offered to patients who have achieved mediastinal downstaging following induction therapy. Careful preoperative evaluation is clearly important in the staging and selection of patients with NSCLC for surgery.
authors: Department of Thoracic and Vascular Surgery, Antwerp University, Hospital, Wilrijkstraat 10, B-2650 Edegem, Antwerp, Belgium. paul.van.schil@uza.be
authors: Paul E
authors: PE
authors: Van Schil
authors: Jeroen M
authors: JM
authors: Hendriks
authors: Marjan
authors: M
authors: Hertoghs
authors: Patrick
authors: P
authors: Lauwers
authors: Cliff
authors: C
authors: Choong
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology* / Q000601:surgery*; D017322:Clinical Trials, Phase II as Topic; D017326:Clinical Trials, Phase III as Topic; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000601:surgery*; D015337:Multicenter Studies as Topic; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging / Q000379:methods; D016032:Randomized Controlled Trials as Topic