title: Lipid metabolism and HCV infection.
abstract: Chronic infection by hepatitis C virus (HCV) can lead to severe liver disease and is a global healthcare problem. The liver is highly metabolically active and one of its key functions is to control the balance of lipid throughout the body. A number of pathologies have been linked to the impact of HCV infection on liver metabolism. However, there is also growing evidence that hepatic metabolic processes contribute to the HCV life cycle. This review summarizes the relationship between lipid metabolism and key stages in the production of infectious HCV.
authors: Pfizer Global Research & Development, Infectious Diseases Group, Sandwich Laboratories, Sandwich, CT13 9NJ, UK.
authors: Paul
authors: P
authors: Targett-Adams
authors: Immune Disease Institute, Harvard Medical School, Department of Microbiology and Molecular Genetics, Boston, MA 02115, USA.
authors: Steeve
authors: S
authors: Boulant
authors: Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, PO Box 412, Westmead, NSW 2145, Australia.
authors: Mark W
authors: MW
authors: Douglas
authors: MRC Virology Unit, Church Street, Glasgow G11 5JR, UK.
authors: John
authors: J
authors: McLauchlan