title: Do cysteine residues regulate transient receptor potential canonical type 6 channel protein expression?
abstract: The regulation of calcium influx through transient receptor potential canonical type 6 (TRPC6) channel is mandatory for the activity of human monocytes. We submit the first evidence that cysteine residues of homocysteine (HC) or acetylcysteine (ACC) affect TRPC6 expression in human monocytes. We observed that patients with chronic renal failure had significantly elevated HC levels and TRPC6 mRNA expression levels in monocytes compared with control subjects. We further observed that administration of HC or ACC significantly increased TRPC6 channel protein expression compared with control conditions. We, therefore, hypothesize that cysteine residues increase TRPC6 channel protein expression in humans.
authors: Department of Medicine, Division of Nephrology, Charité Campus Benjamin Franklin, Berlin, Germany. florian.thilo@charite.de
authors: Florian
authors: F
authors: Thilo
authors: Ying
authors: Y
authors: Liu
authors: Katharina
authors: K
authors: Krueger
authors: Nora
authors: N
authors: Förste
authors: Antje
authors: A
authors: Wittstock
authors: Alexandra
authors: A
authors: Scholze
authors: Martin
authors: M
authors: Tepel
mesh_terms: D000368:Aged; D003545:Cysteine / Q000031:analogs & derivatives / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D009000:Monocytes / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D060888:Real-Time Polymerase Chain Reaction; D050052:TRPC Cation Channels / Q000096:biosynthesis / Q000737:chemistry* / Q000235:genetics*; D000074287:TRPC6 Cation Channel
chemical_list: D012333:RNA, Messenger; D050052:TRPC Cation Channels; D000074287:TRPC6 Cation Channel; C117032:TRPC6 protein, human; D003545:Cysteine