title: Type 2 diabetes is associated with increased pulse wave velocity measured at different sites of the arterial system but not augmentation index in a Chinese population.
abstract: BACKGROUND
  Patients with type 2 diabetes have increased stiffness of central elastic arteries. However, whether peripheral muscular artery stiffness is equally affected by the disease remains sparsely examined. Moreover, the association between pulse wave velocity (PWV) and augmentation index (AIx) in diabetes is poorly understood.
  
  
  OBJECTIVE
  Type 2 diabetes is associated with the alterations in arterial stiffness (PWV and AIx) in a community-based population.
  
  
  METHODS
  A total of 79 Chinese patients with type 2 diabetes and 79 sex-, age- (±3 years), and body mass index- (±2 kg/m(2) ) matched healthy controls were studied. Carotid-femoral pulse wave velocity (CF-PWV), carotid-radial pulse wave velocity (CR-PWV), and carotid-ankle pulse wave velocity (CA-PWV) were calculated from tonometry waveforms and body surface measurements, whereas AIx was assessed using pulse wave analyses.
  
  
  RESULTS
  In univariate analysis, patients with type 2 diabetes showed increased CF-PWV (P < 0.001), CR-PWV (P = 0.012), and CA-PWV (P = 0.016), and lower AIx (P = 0.017) than the control group. In multiple linear regression models adjusting for covariates, type 2 diabetes remained a significant determinant of CF-PWV. Fasting glucose was associated with CR-PWV but was not related to CA-PWV or AIx.
  
  
  CONCLUSIONS
  Our findings suggest that patients with type 2 diabetes have increased central and peripheral artery stiffness, but preserved AIx compared to controls. Diabetes was a predictor of central artery stiffness, and glucose was a determinant of peripheral artery stiffness.
authors: Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.
authors: Minghua
authors: M
authors: Zhang
authors: Yongyi
authors: Y
authors: Bai
authors: Ping
authors: P
authors: Ye
authors: Leiming
authors: L
authors: Luo
authors: Wenkai
authors: W
authors: Xiao
authors: Hongmei
authors: H
authors: Wu
authors: Dejun
authors: D
authors: Liu
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D000842:Ankle / Q000098:blood supply; D001158:Arteries / Q000503:physiopathology*; D044466:Asian People / Q000706:statistics & numerical data; D001783:Blood Flow Velocity; D001786:Blood Glucose / Q000378:metabolism; D001916:Brachial Artery / Q000503:physiopathology; D002339:Carotid Arteries / Q000503:physiopathology; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000208:ethnology / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000097:blood / Q000208:ethnology / Q000209:etiology* / Q000503:physiopathology; D004548:Elasticity; D005260:Female; D005263:Femoral Artery / Q000503:physiopathology; D006801:Humans; D016014:Linear Models; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011673:Pulsatile Flow; D017534:Radial Artery / Q000503:physiopathology; D012039:Regional Blood Flow; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D001786:Blood Glucose