title: Pharmacological and histological effects of Centaurea bruguierana ssp. belangerana on indomethacin-induced peptic ulcer in rats.
abstract: The species Centaurea bruguierana (DC.) Hand.-Mazz. ssp. belangerana (DC.) Bornm. (CBB) (Asteraceae), known as "Baad-Avard" in Borazjan, Bushehr Province, southern Iran, is used in folk medicine as a hypoglycemic herb in diabetes and as a remedy for peptic ulcer disorders. Total 80% EtOH extract and petroleum ether, CHCl(3), EtOAc, n-BuOH, and remaining fractions obtained by solvent-solvent fractionation of dried aerial flowering parts of the plant were investigated for anti-ulcer activity against indomethacin-induced ulcerogenesis in rats. Anti-ulcer activity was evaluated by measuring the ulcer index (UI) and ulcer inhibition. The UI was significantly reduced in all treated animals. A dramatic decrease in the UI was observed following the administration of total extract (100 mg/kg, p < 0.001) and CHCl(3) fraction (42 mg/kg, ***p < 0.001) in comparison with the control group. The percentage ulcer inhibition with total extract at a dose of 100 mg/kg (97.66%) and CHCl(3) fraction at a dose of 42 mg/kg (96.96%) was found to be higher (p < 0.001) than the reference group (cimetidine 100 mg/kg) (87.08%). The pharmacological and histological results of the present study proved that the aerial flowering parts of CBB possess preventive activity against peptic ulcer, supporting the traditional assertion in southern Iranian folk medicine.
authors: Department of Pharmacognosy, Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
authors: Mahnaz
authors: M
authors: Khanavi
authors: Reza
authors: R
authors: Ahmadi
authors: Afsaneh
authors: A
authors: Rajabi
authors: Shaghayegh
authors: S
authors: Jabbari Arfaee
authors: Gholamreza
authors: G
authors: Hassanzadeh
authors: Rahim
authors: R
authors: Khademi
authors: Abbas
authors: A
authors: Hadjiakhoondi
authors: Cordian
authors: C
authors: Beyer
authors: Mohammad
authors: M
authors: Sharifzadeh
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000627:therapeutic use*; D031179:Centaurea / Q000737:chemistry*; D007213:Indomethacin / Q000633:toxicity*; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000188:drug therapy*
chemical_list: D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D007213:Indomethacin