title: Interaction of cells with decellularized biological materials.
abstract: The idea to create the concept of cardiovascular "tissue engineering" is based on the  recognition that until then all known allogeneic/xenogeneic biological or alloplastic  implant materials were associated with shortcomings, which led to graft deterioration,  degradation and finally destruction. Thus, it aims to develop viable cardiovascular  structures, e.g. heart valves, myocardium or blood vessels, which ideally  demonstrate mechanisms of remodeling and self-repair, a high microbiological  resistance, complete immunological integrity and a functional endothelial cell layer to  guarantee physiological hemostasis.  In our current review we aim to identify basic limitations of previous concepts, explain  why the use of decellularized matrices was a logical consequence and which  limitations still exist.
authors: Division of Cardiac, Thoracic, Transplantation and Vascular Surgery, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Germany, wilhelmi.mathias@mh-hannover.de.
authors: Mathias
authors: M
authors: Wilhelmi
authors: Bettina
authors: B
authors: Giere
authors: Michael
authors: M
authors: Harder
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002448:Cell Adhesion / Q000502:physiology*; D002470:Cell Survival / Q000502:physiology*; D002474:Cell-Free System / Q000737:chemistry*; D006801:Humans; D019736:Prostheses and Implants; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials