title: Introduction to induced pluripotent stem cells: advancing the potential for personalized medicine.
abstract: Induced pluripotent stem (iPS) cell technology has enormous potential to advance medical therapy by personalizing regenerative medicine and creating novel human disease models for research and therapeutic testing. Before this technology is broadly used in the clinic, we must realistically evaluate its disease modeling and therapeutic potential. Recent advances including the use of iPS cells to successfully model spinal muscular atrophy in vitro, as well as new techniques in generating iPS cells with recombinant proteins have accelerated the prospects of iPS cells for clinical use in regenerative therapy. This review explores the development and limitations of iPS cell technology, presents a critical comparison of iPS cells and embryonic stem cells, and discusses potential clinical applications and future research directions.
authors: Brain Tumor Research Laboratory, Department of Neurological Surgery, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA.
authors: Johnathan D
authors: JD
authors: Ebben
authors: Michael
authors: M
authors: Zorniak
authors: Paul A
authors: PA
authors: Clark
authors: John S
authors: JS
authors: Kuo
mesh_terms: D000755:Anemia, Sickle Cell / Q000628:therapy; D000818:Animals; D060846:Cell Engineering; D004195:Disease Models, Animal; D006801:Humans; D057026:Induced Pluripotent Stem Cells; D051379:Mice; D009422:Nervous System Diseases / Q000628:therapy*; D009493:Neurosurgery; D010300:Parkinson Disease / Q000628:therapy; D036102:Peripheral Blood Stem Cell Transplantation; D057285:Precision Medicine / Q000379:methods*; D051381:Rats; D044968:Regenerative Medicine