title: Computer-based classification of small colorectal polyps by using narrow-band imaging with optical magnification.
abstract: BACKGROUND
  Recent studies have shown that narrow-band imaging (NBI) is a powerful diagnostic tool for the differentiation between neoplastic and non-neoplastic colorectal polyps.
  
  
  OBJECTIVE
  To develop a computer-based method for classification of colorectal polyps.
  
  
  METHODS
  A prospective study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  A total of 214 patients with colorectal polyps who underwent a zoom NBI colonoscopy.
  
  
  METHODS
  A total of 434 detected polyps 10 mm or smaller were imaged and subsequently removed for histological analysis.
  
  
  METHODS
  Diagnostic performance in polyp classification by 2 experts, 2 nonexperts, and a computer-based algorithm.
  
  
  RESULTS
  The expert group and the computer-based algorithm achieved a comparable diagnostic performance (expert group: 93.4% sensitivity, 91.8% specificity, and 92.7% accuracy; computer-based algorithm: 95.0% sensitivity, 90.3% specificity, and 93.1% accuracy) and were both significantly superior to the nonexpert group (86.0% sensitivity, 87.8% specificity, and 86.8% accuracy) in terms of sensitivity, negative predictive value, and accuracy. Subgroup analysis of 255 polyps 5 mm or smaller revealed comparable results without significant differences in the overall analysis of all polyps.
  
  
  CONCLUSIONS
  No fully automatic classification system.
  
  
  CONCLUSIONS
  The study demonstrates that computer-based classification of colon polyps can be achieved with high diagnostic performance.
authors: Medical Department III (Gastroenterology, Hepatology, and Metabolic Diseases), University Hospital RWTH Aachen, Aachen, Germany.
authors: Sebastian
authors: S
authors: Gross
authors: Christian
authors: C
authors: Trautwein
authors: Alexander
authors: A
authors: Behrens
authors: Ron
authors: R
authors: Winograd
authors: Stephan
authors: S
authors: Palm
authors: Holger H
authors: HH
authors: Lutz
authors: Ramin
authors: R
authors: Schirin-Sokhan
authors: Hartmut
authors: H
authors: Hecker
authors: Til
authors: T
authors: Aach
authors: Jens J W
authors: JJ
authors: Tischendorf
mesh_terms: D000465:Algorithms; D003111:Colonic Polyps / Q000145:classification* / Q000175:diagnosis; D003113:Colonoscopy / Q000379:methods*; D003937:Diagnosis, Differential; D001330:Electronic Data Processing / Q000379:methods*; D005500:Follow-Up Studies; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation*; D008403:Mass Screening / Q000379:methods; D055095:Optics and Photonics; D011446:Prospective Studies; D015203:Reproducibility of Results; D013997:Time Factors