title: Hippocampal plasticity in rats submitted to a gastric restrictive procedure.
abstract: Bariatric surgery has been the most effective therapeutic intervention for morbidly obese patients. However, recent evidence has shown that this procedure may cause serious neurological complications such as Wernicke encephalopathy, depression, and memory impairment. With this in mind,  we conducted an experimental study to investigate whether weight-reduction surgery would promote morphological changes in the hippocampal formation, a brain region linked to cognitive and emotional processes. To do so, the present study evaluated the hippocampal expression of parvalbumin interneurons  in rats submitted to a gastric restrictive procedure (experimental phytobezoar). Our results demonstrated that rats with gastric-reduced capacity presented a significant increase in the expression of the parvalbumin interneurons in the hippocampal CA1 and CA3 subfields. These data are the  first experimental evidence that restrictive bariatric surgery may alter hippocampal cytoarchitecture.
authors: Laboratory of Experimental Neurology, Universidade Federal de São Paulo (UNIFESP), São Paulo - SP, Brasil.
authors: Elisa Yumi de Freitas
authors: EY
authors: Sonoda
authors: Sérgio
authors: S
authors: Gomes da Silva
authors: Ricardo Mario
authors: RM
authors: Arida
authors: Pedro Nogueira
authors: PN
authors: Giglio
authors: Nelson Fontana
authors: NF
authors: Margarido
authors: Carlos Augusto Real
authors: CA
authors: Martinez
authors: Aline Priscila
authors: AP
authors: Pansani
authors: Rude de Souza
authors: Rde S
authors: Maciel
authors: Esper Abrão
authors: EA
authors: Cavalheiro
authors: Fulvio Alexandre
authors: FA
authors: Scorza
mesh_terms: D000818:Animals; D050110:Bariatric Surgery / Q000009:adverse effects* / Q000379:methods; D001630:Bezoars; D001835:Body Weight; D056547:CA1 Region, Hippocampal / Q000166:cytology / Q000502:physiology*; D056654:CA3 Region, Hippocampal / Q000166:cytology / Q000502:physiology*; D003072:Cognition Disorders / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D004195:Disease Models, Animal; D007395:Interneurons / Q000378:metabolism; D029776:Luffa; D008297:Male; D009473:Neuronal Plasticity / Q000502:physiology*; D009748:Nutrition Disorders / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D010320:Parvalbumins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013270:Stomach / Q000601:surgery
chemical_list: D010320:Parvalbumins