title: Association between tumor necrosis factor-α-308G/A polymorphism and obstructive sleep apnea: a meta-analysis.
abstract: OBJECTIVE
  The tumor necrosis factor (TNF)-α-308G/A polymorphism has been implicated in susceptibility to obstructive sleep apnea (OSA). However, results from previous studies are inconsistent. A systematic review and meta-analysis of the published studies was performed to investigate this association.
  
  
  METHODS
  We searched PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), and Weipu databases for published studies evaluating the association between -308G/A polymorphism and OSA. Data were extracted using standardized forms and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.
  
  
  RESULTS
  Four case-control studies involving a total of 419 cases and 460 controls were included in the meta-analysis. Combined data indicated that individuals carrying the -308A allele had a 65% increased risk of developing OSA when compared with the GG homozygotes (OR=1.65, 95% CI=1.02-2.68, p=0.04). In adults, the risk was even higher, elevated by 100% (OR=2.00, 95% CI=1.26-3.18, p=0.003).
  
  
  CONCLUSIONS
  The TNF-α-308G/A polymorphism contributes to the risk of OSA, especially in adults.
authors: Institute of Respiratory Diseases, First Affiliated Hospital, Guangxi Medical University, Nanning, China.
authors: Jian
authors: J
authors: Huang
authors: Ning
authors: N
authors: Liao
authors: Qiu-Pin
authors: QP
authors: Huang
authors: Zheng-Fu
authors: ZF
authors: Xie
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002648:Child; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D020181:Sleep Apnea, Obstructive / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D014409:Tumor Necrosis Factor-alpha