title: Designing 2-aminoimidazole alkaloids analogs with anti-biofilm activities: structure-activities relationships of polysubstituted triazoles.
abstract: In order to discover novel probes that may help in the investigation and the control of bacterial biofilms, we have designed a library of triazole-based analogs of 2-aminoimidazole marine alkaloids: naamine A and isonaamine A. Twenty-two compounds were screened for their biofilm inhibitory activity against two strains of Gram-negative bacteria. Four compounds were shown to act as non-toxic inhibitors of biofilm development without effect on bacterial growth even at high concentrations (100 μM).
authors: Laboratoire MAPIEM, EA 4323, UFR Sciences et Techniques, Université du Sud Toulon-Var, 83957 La Garde cedex, France.
authors: D
authors: D
authors: Linares
authors: O
authors: O
authors: Bottzeck
authors: O
authors: O
authors: Pereira
authors: A
authors: A
authors: Praud-Tabariès
authors: Y
authors: Y
authors: Blache
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D015195:Drug Design; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000502:physiology; D007093:Imidazoles / Q000737:chemistry* / Q000494:pharmacology*; D008958:Models, Molecular; D010230:Paracoccus / Q000187:drug effects / Q000502:physiology; D031161:Pseudoalteromonas / Q000187:drug effects / Q000502:physiology; D054852:Small Molecule Libraries / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D007093:Imidazoles; D054852:Small Molecule Libraries; D014230:Triazoles; C014973:2-aminoimidazole