title: Effects of pioglitazone add-on to gliclazide and metformin on glycemic control in patients with type 2 diabetes.
abstract: OBJECTIVE
  This study aims to evaluate the efficacy and safety of adding pioglitazone to treatment with metformin (MF) and gliclazide in patients with type 2 diabetes mellitus (DM2) who had inadequate glycemic control.
  
  
  METHODS
  This study is a retrospective cohort study based on King Abdullah University Hospital records concerning type 2 diabetic adult patients for year 2008. Patients included were assessed according to changes in glycosylated hemoglobin (HbA1c), lipid profile, albuminuria and liver enzymes before and after the addition of pioglitazone.
  
  
  RESULTS
  The patients included in the study had an initial mean HbA1c of 9.44%, which decreased to 7.56% after the addition of pioglitazone (P-value < 0.005).
authors: Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology , Irbid , Jordan. sayerazzam@yahoo.com
authors: Sayer I
authors: SI
authors: Al-Azzam
authors: Mousa
authors: M
authors: Alomari
authors: Yousef S
authors: YS
authors: Khader
authors: Fatimah A
authors: FA
authors: Almahasneh
authors: Suhaib M
authors: SM
authors: Muflih
authors: Shoroq
authors: S
authors: Altawalbeh
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D005907:Gliclazide / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008687:Metformin / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D000077205:Pioglitazone; D012189:Retrospective Studies; D045162:Thiazolidinediones / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D008687:Metformin; D005907:Gliclazide; D000077205:Pioglitazone