title: Penile duplex ultrasonography in men with Peyronie's disease: is it veno-occlusive dysfunction or poor cavernosal arterial inflow that contributes to erectile dysfunction?
abstract: BACKGROUND
  At least 20% of men with Peyronie's disease (PD) suffer from erectile dysfunction (ED). The fundamental mechanism is thought to arise from the progression of penile fibrosis, which was initially limited to the PD plaque within the tunica albuginea. However, recent studies have highlighted the possibility of fibrosis of the cavernosal vessel media wall leading to impairment of arterial inflow.
  
  
  OBJECTIVE
  To evaluate the penile duplex ultrasonographic findings in PD of impotent men and to determine whether early features of PD might predict clinical progression.
  
  
  METHODS
  Patient demographic, comorbidities, International Index of Erectile Function-5 scores, surgical intervention, and physical findings were documented. Penile curvature, plaque size, and peak systolic velocity (PSV) and end-diastolic velocity (EDV) on color duplex ultrasonography (CDU) were recorded.
  
  
  METHODS
  We performed a retrospective review of all men presenting with penile curvature and length loss who underwent penile CDU between January 2001 and January 2010.
  
  
  RESULTS
  A total of 1,120 men underwent penile CDU during the 10-year period. Complete information was obtained in 810 men; 250 men complained of decreased penile rigidity, while 150 men were unable to sustain erection. Comorbidities were similar between men with PD with and without ED. Tunical thickening (65%) was the most common CDU feature, and mean cumulative calcifications was 24.2 mm(2) (1-360 mm(2) , standard deviation 76). The PSV and EDV on the right cavernosal artery were 14.2 cm/second and 3.5 cm/second, while the left cavernosal artery measurements were 15.1 cm/second and 3.2 cm/second. Multivariate logistic regression model showed strong correlation between plaque size and development of ED. Both veno-occlusive dysfunction and impaired cavernosal arterial inflow were associated with ED.
  
  
  CONCLUSIONS
  Veno-occlusive dysfunction and impaired cavernosal arterial inflow contributed to the development of ED, and larger plaque size is a strong predictor of surgical intervention.
authors: Department of Urology, Princess Alexandra Hospital, Brisbane, QLD, Australia. ericchg@hotmail.com
authors: Eric
authors: E
authors: Chung
authors: Ling
authors: L
authors: De Young
authors: Gerald B
authors: GB
authors: Brock
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D018450:Disease Progression; D007172:Erectile Dysfunction / Q000000981:diagnostic imaging* / Q000473:pathology; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010411:Penile Induration / Q000000981:diagnostic imaging* / Q000473:pathology; D010413:Penis / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology; D012189:Retrospective Studies; D018616:Ultrasonography, Doppler, Duplex; D055815:Young Adult