title: Hippocampal effects of neuronostatin on memory, anxiety-like behavior and food intake in rats.
abstract: A 13-amino acid peptide named neuronostatin (NST) encoded in the somatostatin pro-hormone has been recently reported. It is produced throughout the body, particularly in brain areas that have significant actions over the metabolic and autonomic regulation. The present study was performed in order to elucidate the functional role of NST on memory, anxiety-like behavior and food intake and the hippocampal participation in these effects. When the peptide was intra-hippocampally administered at 3.0 nmol/μl, it impaired memory retention in both, object recognition and step-down test. Also, this dose blocked the hippocampal long-term potentiation (LTP) generation. When NST was intra-hippocampally administered at 0.3 nmol/μl and 3.0 nmol/μl, anxiolytic effects were observed. Also, the administration in the third ventricle at the higher dose (3.0 nmol/μl) induced similar effects, and both doses reduced food intake. The main result of the present study is the relevance of the hippocampal formation in the behavioral effects induced by NST, and these effects could be associated to a reduced hippocampal synaptic plasticity.
authors: Cátedra de Fisiología Humana, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Santa Rosa 1085, 5000 Córdoba, Argentina. vcarlini@live.com.ar
authors: V P
authors: VP
authors: Carlini
authors: M
authors: M
authors: Ghersi
authors: L
authors: L
authors: Gabach
authors: H B
authors: HB
authors: Schiöth
authors: M F
authors: MF
authors: Pérez
authors: O A
authors: OA
authors: Ramirez
authors: M
authors: M
authors: Fiol de Cuneo
authors: S R
authors: SR
authors: de Barioglio
mesh_terms: D000818:Animals; D001007:Anxiety / Q000378:metabolism*; D004435:Eating / Q000187:drug effects / Q000502:physiology*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D017774:Long-Term Potentiation / Q000187:drug effects / Q000502:physiology; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D018408:Patch-Clamp Techniques; D010446:Peptide Fragments / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013004:Somatostatin / Q000378:metabolism*
chemical_list: D010446:Peptide Fragments; C554543:neuronostatin protein, rat; D013004:Somatostatin