title: Move or die: the fate of the Tax oncoprotein of HTLV-1.
abstract: The HTLV-1 Tax protein both activates viral replication and is involved in HTLV-1-mediated transformation of T lymphocytes. The transforming properties of Tax include altering the expression of select cellular genes via activation of cellular pathways and perturbation of both cell cycle control mechanisms and apoptotic signals. The recent discovery that Tax undergoes a hierarchical sequence of posttranslational modifications that control its intracellular localization provides provocative insights into the mechanisms regulating Tax transcriptional and transforming activities.
authors: Institut de Recherches Microbiologiques J-M Wiame, Université Libre de Bruxelles, B-1070 Bruxelles, Belgium. jlodewic@ulb.ac.be
authors: Julie
authors: J
authors: Lodewick
authors: Isabelle
authors: I
authors: Lamsoul
authors: Françoise
authors: F
authors: Bex
mesh_terms: D000818:Animals; D002472:Cell Transformation, Viral; D016356:Gene Products, tax / Q000235:genetics / Q000378:metabolism*; D015490:HTLV-I Infections / Q000235:genetics / Q000378:metabolism / Q000821:virology*; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction; D015533:Transcriptional Activation
chemical_list: D016356:Gene Products, tax; C514970:tax protein, Human T-lymphotrophic virus 1