title: Chronic toxicity of erythromycin thiocyanate to Daphnia magna in a flow-through, continuous exposure test system.
abstract: Approval of a new animal drug application for AQUAMYCIN 100(®) (erythromycin thiocyanate; ET) to treat freshwater salmonid species with bacterial kidney disease is being pursued in the US. As part of the approval process, ET's impact on an aquatic environment had to be described in an environmental assessment. The environmental assessment was lacking data to characterize the effect ET would have on a chronically exposed aquatic invertebrate organism. A major step to fulfilling the environmental assessment was completed after conducting a comprehensive study continuously exposing Daphnia magna to ET for 21 days. Results indicated that the no observable effect concentration for ET was 179 μg/L.
authors: Biological Resources Division, US Geological Survey, Upper Midwest Environmental Sciences Center, 2630 Fanta Reed Road, La Crosse, WI 54603, USA. jmeinertz@usgs.gov
authors: Jeffery R
authors: JR
authors: Meinertz
authors: Theresa M
authors: TM
authors: Schreier
authors: Jeffry A
authors: JA
authors: Bernardy
mesh_terms: D000818:Animals; D003621:Daphnia / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004784:Environmental Monitoring / Q000379:methods; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000633:toxicity; D005618:Fresh Water / Q000737:chemistry; D012098:Reproduction / Q000187:drug effects; D036401:Toxicity Tests, Chronic / Q000379:methods*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D014874:Water Pollutants, Chemical; D004917:Erythromycin; C025000:erythromycin thiocyanate