title: Spontaneous uterine perforation of choriocarcinoma with negative beta-human chorionic gonadotropin after chemotherapy.
abstract: OBJECTIVE
  To report an extremely rare case of spontaneous uterine perforation of choriocarcinoma with negative beta-human chorionic gonadotropin (β-hCG) post-chemotherapy.
  
  
  METHODS
  We present a 35-year-old choriocarcinoma patient whose serial serum β-hCG levels following a fifth course of chemotherapy had been within the normal range, but who developed spontaneous uterine perforation with intra-abdominal hemorrhage after eight courses of combined chemotherapy. The patient then underwent an emergency hysterectomy and survived.
  
  
  CONCLUSIONS
  Patients with persistent focus of disease in the uterus might experience uterine perforation even after adequate chemotherapy, and therefore, the follow-up for patients after chemotherapy is very important.
authors: Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu, PR China.
authors: Chuan
authors: C
authors: Xie
authors: Lan
authors: L
authors: Zheng
authors: Zheng-Yu
authors: ZY
authors: Li
authors: Xia
authors: X
authors: Zhao
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D014408:Biomarkers, Tumor; D002822:Choriocarcinoma / Q000097:blood / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D006063:Chorionic Gonadotropin / Q000097:blood*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007813:Laparotomy; D011247:Pregnancy; D013997:Time Factors; D014592:Uterine Hemorrhage / Q000209:etiology* / Q000601:surgery; D014594:Uterine Neoplasms / Q000097:blood / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D014595:Uterine Perforation / Q000209:etiology* / Q000601:surgery
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D006063:Chorionic Gonadotropin