title: HNF1B polymorphism associated with development of prostate cancer in Korean patients.
abstract: OBJECTIVE
  To identify whether the genetic variations in HNF1B are associated with the development of prostate cancer in Korean patients. Genome-wide association studies have found the HNF1B gene at 17q12 to be a major causal gene for the risk of prostate cancer.
  
  
  METHODS
  We evaluated the association of 47 single nucleotide polymorphisms (SNPs) in the HNF1B gene with prostate cancer risk and clinical characteristics (Gleason score and tumor stage) in Korean men (240 case subjects and 223 control subjects) using unconditional logistic regression analysis.
  
  
  RESULTS
  Of the 47 SNPs, 14 were associated with prostate cancer risk (P = .002-.02); 9 SNPs were associated with a lower risk of prostate cancer (odds ratio 0.67-0.71, P = .005-.05), and 5 SNPs were associated with a greater risk of disease (odds ratio 1.49-1.51, P = .002-.02). In an analysis involving only patients with prostate cancer, 1 SNP (rs11868513) in the HNF1B gene was more frequent in patients with tumors with a greater stage than in those with a lower tumor stage. Two SNPs (rs4430796 and rs2074429) and 1 haplotype (Block3_ht1) were more frequent in patients with Gleason score of ≥7 than in those with Gleason score <6.
  
  
  CONCLUSIONS
  As in studies from other populations, our findings indicate that HNF1B is also associated with prostate cancer risk in the Korean population.
authors: Advanced Urogenital Disease Research Center, Chung-Ang University College of Medicine, Seoul, South Korea.
authors: Hae Jong
authors: HJ
authors: Kim
authors: Joon Seol
authors: JS
authors: Bae
authors: Jaehyouk
authors: J
authors: Lee
authors: In Ho
authors: IH
authors: Chang
authors: Kyung Do
authors: KD
authors: Kim
authors: Hyoung Doo
authors: HD
authors: Shin
authors: June Hyun
authors: JH
authors: Han
authors: Shin Young
authors: SY
authors: Lee
authors: Wonyong
authors: W
authors: Kim
authors: Soon Chul
authors: SC
authors: Myung
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D006239:Haplotypes; D051539:Hepatocyte Nuclear Factor 1-beta / Q000235:genetics*; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*; D012044:Regression Analysis; D012306:Risk
chemical_list: C496495:HNF1B protein, human; D051539:Hepatocyte Nuclear Factor 1-beta