title: [Comparison of two bedside tests performed on cervicovaginal fluid to diagnose premature rupture of membranes].
abstract: OBJECTIVE
  To compare the performance of two rapid tests for the diagnosis of premature rupture of membranes (PROM) based on the detection of the insulin-like growth factor-binding protein-1 (IGFBP-1) and placental α-microglobulin-1 (PAMG-1) in cervicovaginal secretions.
  
  
  METHODS
  A case-control prospective study. Pregnant women between 24 and 41(6/7) weeks' of gestation, consulting for profuse amniotic fluid loss (group 1) or for other reasons without any rupture of membrane (group 2) were included in the study. Successively, AmniSure(®) test (PAMG-1) without speculum, and then Actim™Prom test (IGFBP-1) during speculum examination were performed during the same visit.
  
  
  RESULTS
  Eighty subjects (40 in each group) were included between 25(1/7) to 41(1/7) weeks of gestation. AmniSure(®) diagnostic test demonstrated a sensitivity and specificity of 95 % (82.4-99.4) and 94.8 % (79.3-98) respectively and a positive and negative predictive value of 95 % (84.7-100) and 94.8 % (87.9-100) respectively. Actim™Prom diagnostic test demonstrated a sensitivity and specificity of 97.5 % (85.7-100) and 97.4 % (82.4-99.4) respectively and a positive and negative predictive value of 97.5 % (88.5-100) and 97.4 % (92.5-100) respectively.
  
  
  CONCLUSIONS
  Both tests have similar performance to diagnose premature rupture of membranes.
authors: Maternité Port-Royal, hôpital Cochin Saint-Vincent-de-Paul, AP-HP, université Paris Descartes, 123, boulevard de Port-Royal, 75014 Paris, France. louismarcellin@hotmail.com
authors: L
authors: L
authors: Marcellin
authors: O
authors: O
authors: Anselem
authors: J
authors: J
authors: Guibourdenche
authors: A
authors: A
authors: De la Calle
authors: C
authors: C
authors: Deput-Rampon
authors: D
authors: D
authors: Cabrol
authors: V
authors: V
authors: Tsatsaris
mesh_terms: D000328:Adult; D000510:Alpha-Globulins / Q000032:analysis; D001826:Body Fluids / Q000737:chemistry; D016022:Case-Control Studies; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000175:diagnosis*; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000032:analysis; D019095:Point-of-Care Systems; D011247:Pregnancy; D012680:Sensitivity and Specificity; D014621:Vagina / Q000378:metabolism; D014626:Vaginal Smears / Q000379:methods*; D055815:Young Adult
chemical_list: D000510:Alpha-Globulins; C032231:IGFBP1 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1; C016001:alpha-1-microglobulin