title: Platelet-rich plasma for the replenishment of bone.
abstract: This review examines the use of platelet-rich plasma (PRP) in the treatment of bone injuries and to stimulate bone formation. Studies examining both in vivo bone healing and in vitro actions of PRP on osteoblasts are reviewed. Overall, the available literature suggests that PRP does not appreciably impact bone healing or induce bone formation. However, there is some evidence to suggest that PRP might augment recruitment of osteoblast progenitors to injection sites or in sites expected to experience delayed healing. In this capacity PRP might be utilized to initiate repair of an otherwise poorly healing skeletal lesion. The demonstration that PRP is a viable therapy is hindered by a lack of standardized criteria for what constitutes PRP, and more studies are needed to compare the efficacy of PRP to that of transforming growth factor-β or platelet-derived growth factor used as sole agents.
authors: Department of Pathology and Lab Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA. drjamesiqbal@gmail.com
authors: Jameel
authors: J
authors: Iqbal
authors: Samuel H
authors: SH
authors: Pepkowitz
authors: Ellen
authors: E
authors: Klapper
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000293:injuries* / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D023421:Models, Animal; D010006:Osteoblasts / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology*; D010982:Platelet-Derived Growth Factor / Q000502:physiology; D053657:Platelet-Rich Plasma / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000502:physiology; D014945:Wound Healing / Q000502:physiology*
chemical_list: D010982:Platelet-Derived Growth Factor; D016212:Transforming Growth Factor beta