title: Potential of proteomics as a bioanalytic technique for quantifying sleepiness.
abstract: Currently, there are no simple ways to assess the degree of sleep loss in individual subjects. Proteins constitute greater than 98% of all molecules in the cell. They participate in physiological interactions, explain all of posttranslational modifications that occur in cellular micro-environments and thus are potential candidates for identification of a biomarker of sleepiness. A variety of proteonomic techniques are available which are being used in a current sleep deprivation study of monozygotic and dizygotic twin pairs we are performing.
authors: Center for Sleep and Circadian Neurobiology, Division of Sleep Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. naidoo@mail.med.upenn.edu
authors: Nirinjini
authors: N
authors: Naidoo
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D004200:Diseases in Twins; D006970:Disorders of Excessive Somnolence / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism*; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D020543:Proteome / Q000378:metabolism*; D040901:Proteomics / Q000379:methods*; D012892:Sleep Deprivation / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism*; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic
chemical_list: D015415:Biomarkers; D020543:Proteome