title: The powerstroke and camshaft of the RIG-I antiviral RNA detection machine.
abstract: The innate immune sensor RIG-I responds to infection by binding to viral double-stranded RNA (dsRNA). In this issue of Cell, Kowalinski et al. (2011) and Luo et al. (2011) reveal the structure of RIG-I, and in combination with functional analyses, they show how RIG-I recognizes viral RNA to initiate signaling and a type I interferon response.
authors: Immunology Research Centre, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland. laoneill@tcd.ie
authors: Luke A J
authors: LA
authors: O'Neill
authors: Andrew G
authors: AG
authors: Bowie