title: Macrophages in cancer and infectious diseases: the 'good' and the 'bad'.
abstract: Macrophages are crucial orchestrators of host defence and tissue homeostasis. Macrophages are heterogeneous and plastic cells that in response to different microenvironmental signals can mount a broad spectrum of different programs of polarized activation. In different pathological contexts including cancer and infectious diseases, macrophages diversity and plasticity may act as a double-edged sword. The elucidation of the molecular mechanisms underlying macrophages recruitment and functional activation allows the identification of valuable targets for the development of innovative therapeutic approaches.
authors: DiSCAFF, University of Piemonte Orientale A. Avogadro, Novara, Italy.
authors: Chiara
authors: C
authors: Porta
authors: Elena
authors: E
authors: Riboldi
authors: Maria Grazia
authors: MG
authors: Totaro
authors: Laura
authors: L
authors: Strauss
authors: Antonio
authors: A
authors: Sica
authors: Alberto
authors: A
authors: Mantovani
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D002465:Cell Movement / Q000276:immunology; D060833:Cellular Microenvironment / Q000276:immunology; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy / Q000639:trends; D007239:Infections / Q000276:immunology* / Q000628:therapy; D007249:Inflammation; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology*; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D058408:Th1-Th2 Balance
chemical_list: D016207:Cytokines