title: Impact of Ca2+ signaling on B cell function.
abstract: In B cells, changes in intracellular concentration of Ca(2+) drive signal transduction to initiate changes in gene expression and various cellular events, including apoptosis and differentiation. B cell receptor engagement causes a transient Ca(2+) flux from the endoplasmic reticulum Ca(2+) store, followed by a continuous increase in intracellular Ca(2+) concentration, mainly resulting from store-operated Ca(2+) entry (SOCE). The recent identification of stromal interaction molecule (STIM) and Orai as essential components for SOCE has allowed researchers to probe further the role of Ca(2+) signals in B cell biology. Here, we summarize the B cell signaling pathways that lead to SOCE, the role of Ca(2+) signals in B cell regulatory function, and how a breakdown in the balance of Ca(2+) signals is associated with immune-related disease.
authors: Laboratory for Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan. babay@ifrec.osaka-u.ac.jp
authors: Yoshihiro
authors: Y
authors: Baba
authors: Tomohiro
authors: T
authors: Kurosaki
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling; D004721:Endoplasmic Reticulum / Q000276:immunology / Q000378:metabolism; D005110:Extracellular Space / Q000276:immunology / Q000378:metabolism; D006801:Humans
chemical_list: D002118:Calcium