title: Comparative analysis of hemagglutinin of 2009 H1N1 influenza A pandemic indicates its evolution to 1918 H1N1 pandemic.
abstract: To gain insight into the possible origin of the hemagglutinin of 2009 outbreak, we performed its comparative analysis with hemagglutinin of influenza viral strains from 2005 to 2008 and the past pandemics of 1977, 1968, 1957 and 1918. This insilico analysis showed a maximum sequence similarity between 2009 and 1918 pandemics. Primary structure analysis, antigenic and glycosylation site analyses revealed that this protein has evolved from 1918 pandemic. Phylogenetic analysis of HA amino acid sequence of 2009 influenza A(H1N1) viruses indicated that this virus possesses a distinctive evolutionary trait with 1918 influenza A virus. Although the disordered sequences are different among all the isolates, the disordered positions and sequences between 2009 and 1918 isolates show a greater similarity. Thus these analyses contribute to the evidence of the evolution of 2009 pandemic from 1918 influenza pandemic. This is the first computational evolutionary analysis of HA protein of 2009 H1N1 pandemic.
authors: Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia. tahamasoodi@gmail.com
authors: Tariq Ahmad
authors: TA
authors: Masoodi
authors: Noor Ahmad
authors: NA
authors: Shaik
authors: Gowhar
authors: G
authors: Shafi
authors: Anjana
authors: A
authors: Munshi
authors: A Khaleel
authors: AK
authors: Ahamed
authors: Zahid A
authors: ZA
authors: Masoodi
mesh_terms: D019143:Evolution, Molecular; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics* / Q000276:immunology; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics*; D058873:Pandemics; D010802:Phylogeny; D017433:Protein Structure, Secondary; D012689:Sequence Homology, Nucleic Acid
chemical_list: D019267:Hemagglutinin Glycoproteins, Influenza Virus