title: Correlation between expression of S100A4 and VEGF-C, and lymph node metastasis and prognosis in gastric carcinoma.
abstract: This semiquantitative immunohistochemical study investigated the clinical significance of S100A4 and vascular endothelial growth factor C (VEGF-C) protein expression in gastric carcinoma. Correlations between S100A4 and VEGF-C immunoreactivity and clinicopathological characteristics were evaluated using 108 gastric carcinoma specimens and 20 specimens of tissue adjacent to gastric carcinoma. S100A4 and VEGF-C expression in carcinoma was higher than that in adjacent tissues. S100A4 expression was significantly related to tumour size and lymph node metastasis, whereas VEGF-C expression was associated with invasion depth, lymph node metastasis and tumour, node, metastasis (TNM) stage. A significant correlation was found between S100A4 and VEGF-C expression. Patients expressing S100A4 or VEGF-C showed no significant reduction in 5-year survival rate compared with those not expressing these proteins. Sex, age, tumour size, invasion depth, lymph node involvement, TNM stage, S100A4 expression and VEGF-C expression had a common effect on carcinoma prognosis but none was an independent prognostic factor.
authors: Department of Surgery, The Second Hospital of Jiaxing City, Jiaxing, Zhejiang Province, China. lianzhongfengzh@163.com
authors: L-Z
authors: LZ
authors: Feng
authors: X-Y
authors: XY
authors: Zheng
authors: L-X
authors: LX
authors: Zhou
authors: B
authors: B
authors: Fu
authors: Y-W
authors: YW
authors: Yu
authors: S-C
authors: SC
authors: Lu
authors: N-S
authors: NS
authors: Cao
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D012189:Retrospective Studies; D000071999:S100 Calcium-Binding Protein A4; D009418:S100 Proteins / Q000378:metabolism*; D012737:Sex Factors; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology*; D042582:Vascular Endothelial Growth Factor C / Q000378:metabolism*
chemical_list: D000071999:S100 Calcium-Binding Protein A4; D009418:S100 Proteins; C467486:VEGFC protein, human; D042582:Vascular Endothelial Growth Factor C; C077591:S100A4 protein, human