title: Bradykinin promotes TLR2 expression in human gingival fibroblasts.
abstract: Bradykinin (BK) is implicated in the sensation of pain, vasodilation, increases in vascular permeability and pathogenic processes associated with inflammation. Studies have shown that BK promotes the intracellular movement of calcium in human gingival fibroblasts by binding to the B2 receptor. In this study we investigated the effect of BK on regulation of Toll-like receptor 2 (TLR2) expression. Our results show that BK stimulates TLR2 receptor transcription and translation by activation of protein kinase C as well as AKT. Our study contributes important information on the regulation and expression of molecules that promote chronic inflammatory processes, which lead to periodontitis and consequently to loss of the dental organ.
authors: Laboratorio de Bioquímica, División de Estudios de Posgrado e Investigación, Facultad de Odontología, Universidad Nacional Autónoma de México, Ciudad Universitaria, México Distrito Federal, C.P. 045010, Mexico. gloria@fo.odonto.unam.mx
authors: Gloria
authors: G
authors: Gutiérrez-Venegas
authors: Juan Antonio
authors: JA
authors: Arreguín-Cano
mesh_terms: D001920:Bradykinin / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000502:physiology*; D002478:Cells, Cultured; D051546:Cyclooxygenase 2 / Q000096:biosynthesis; D015237:Dinoprost / Q000378:metabolism; D005347:Fibroblasts / Q000187:drug effects / Q000276:immunology; D005881:Gingiva / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D006801:Humans; D011493:Protein Kinase C / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D051195:Toll-Like Receptor 2 / Q000096:biosynthesis*
chemical_list: C495342:TLR2 protein, human; D051195:Toll-Like Receptor 2; D015237:Dinoprost; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D051057:Proto-Oncogene Proteins c-akt; D011493:Protein Kinase C; D001920:Bradykinin