title: Association of pregnancy-associated plasma protein A polymorphism with preeclampsia - a pilot study.
abstract: OBJECTIVE
  The aim of the study was to investigate genetic and biochemical background of PAPP-A (pregnancy-associated plasma protein A) in patients with risk pregnancies.
  
  
  METHODS
  Five PAPP-A gene polymorphisms and PAPP-A maternal serum levels were studied together in 165 women in third trimester pregnancies complicated with threatening preterm labor (n=98), preeclampsia (n=35), intrauterine growth restriction (n=34) and ICP (intrahepatic cholestasis of pregnancy) (n=15). 114 healthy pregnant women served as controls.
  
  
  RESULTS
  Preeclamptic patients had significantly higher frequency of TT genotype of Cys327Cys polymorphism compared to controls (p<0.01). Patients with ICP had increased serum levels of PAPP-A compared to controls and correlation analysis showed significant relationship between PAPP-A and CRP (C-reactive protein) in the patients with intrauterine growth restriction (r=0.49, p=0.007).
  
  
  CONCLUSIONS
  Our study indicates the association of TT genotype of Cys327Cys polymorphism of the PAPP-A gene with preeclampsia. However, further study with larger groups of preeclamptic patients is needed to confirm our results.
authors: Institute of Clinical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, U nemocnice 2, 128 08 Prague, Czech Republic.
authors: Alexandra
authors: A
authors: Muravská
authors: Anna
authors: A
authors: Germanová
authors: Marie
authors: M
authors: Jáchymová
authors: Zdeněk
authors: Z
authors: Hájek
authors: Jana
authors: J
authors: Svarcová
authors: Tomáš
authors: T
authors: Zima
authors: Marta
authors: M
authors: Kalousová
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D010865:Pilot Projects; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D011266:Pregnancy-Associated Plasma Protein-A / Q000235:genetics* / Q000378:metabolism; D012307:Risk Factors; D017422:Sequence Analysis, DNA
chemical_list: D011266:Pregnancy-Associated Plasma Protein-A