title: [Advances in parallel artificial membrane permeability assay and its applications].
abstract: With the development of drug discovery, more and more candidate compounds need to be studied. Methods that can screen compound rapidly received significant attention. Parallel artificial membrane permeability assay (PAMPA) as a powerful tool has been applied to drug studies. It uses an artificial lipid membrane to mimic the barrier for drug permeability studies. This article introduces the establishment and characteristics of PAMPA, as well as its applications in screening compounds. It can be used as models (e.g. predicting the ability of compound in gastro-intestinal absorption, blood-brain barrier transportation and skin penetration) by changing the component of artificial lipid membrane. PAMPA has advantages in high throughput selection of valuable compound with low cost, versatile, low dose, and good reproducibility.
authors: Institute of Pharmaceutics, School of Pharmacy, Lanzhou University, Lanzhou 730000, China.
authors: Yi-Fan
authors: YF
authors: Wu
authors: Hui
authors: H
authors: Liu
authors: Jing-Man
authors: JM
authors: Ni
mesh_terms: D000042:Absorption; D000818:Animals; D001812:Blood-Brain Barrier; D002463:Cell Membrane Permeability; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption; D008567:Membranes, Artificial; D010539:Permeability; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D012869:Skin Absorption
chemical_list: D008567:Membranes, Artificial; D004364:Pharmaceutical Preparations