title: Effects of sevoflurane and propofol on pulmonary inflammatory responses during lung resection.
abstract: OBJECTIVE
  Pulmonary inflammatory reactions are affected by one-lung ventilation (OLV) and anesthetic agents. However, the effects of anesthetic agents on pulmonary inflammatory reactions may vary. Our previous investigations suggested that inflammatory reactions were more pronounced in the dependent lung during lung resection under general anesthesia with propofol and remifentanil. Therefore, in the present study we attempted to determine the difference in pulmonary inflammatory reaction using either sevoflurane or propofol in both dependent and nondependent lungs during OLV.
  
  
  METHODS
  Forty adult patients undergoing elective lung resection were randomized to receive either propofol (n = 20) or sevoflurane (n = 20) as the main anesthetic agent. Intraoperative analgesia was provided by remifentanil in both groups. Epithelial lining fluid (ELF) was obtained from each lung using a bronchoscopic microsampling method. ELF and plasma levels of inflammatory cytokines were measured using multiplexed bead-based immunoassays before and after OLV.
  
  
  RESULTS
  Epithelial lining fluid levels of interleukin (IL)-1β, IL-6, and IL-8 were significantly increased in the dependent lung and the nondependent lung after OLV compared with baseline levels (P < 0.05). Moreover, IL-6 ELF level in the dependent lung was significantly higher in the propofol group than in the sevoflurane group after OLV (P < 0.001).
  
  
  CONCLUSIONS
  One-lung ventilation induced inflammatory responses of the bronchial epithelia in the dependent lung and the nondependent lung during lung resection. Moreover, this inflammatory response was significantly suppressed by sevoflurane compared with propofol. Furthermore, the antiinflammatory effect of sevoflurane was more pronounced in the dependent lung than in the nondependent lung during OLV.
authors: Department of Anesthesiology and Pain Medicine, Juntendo University School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo, 113-8431, Japan. ysugasa@juntendo.ac.jp
authors: Yusuke
authors: Y
authors: Sugasawa
authors: Keisuke
authors: K
authors: Yamaguchi
authors: Seiichiro
authors: S
authors: Kumakura
authors: Taisuke
authors: T
authors: Murakami
authors: Kenji
authors: K
authors: Suzuki
authors: Isao
authors: I
authors: Nagaoka
authors: Eiichi
authors: E
authors: Inada
mesh_terms: D000328:Adult; D000368:Aged; D000777:Anesthetics / Q000494:pharmacology*; D016207:Cytokines / Q000096:biosynthesis; D005260:Female; D006801:Humans; D008168:Lung / Q000187:drug effects* / Q000276:immunology; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology*; D008875:Middle Aged; D011013:Pneumonectomy; D015742:Propofol / Q000494:pharmacology*; D011446:Prospective Studies; D012121:Respiration, Artificial; D000077149:Sevoflurane; D016037:Single-Blind Method
chemical_list: D000777:Anesthetics; D016207:Cytokines; D008738:Methyl Ethers; D000077149:Sevoflurane; D015742:Propofol