title: Changes in central macular thickness after uncomplicated corneal transplantation for keratoconus: penetrating keratoplasty versus deep anterior lamellar keratoplasty.
abstract: OBJECTIVE
  The aim of this study was to assess changes in macular thickness by means of optical coherence tomography after penetrating keratoplasty (PKP) and deep anterior lamellar keratoplasty (DALK) for keratoconus.
  
  
  METHODS
  This prospective study comprised 60 eyes of 60 patients who had keratoplasty for the treatment of keratoconus. Eyes were divided into 2 groups according to the keratoplastic technique applied: PKP group and DALK group. Measurements of central macular thickness were performed preoperatively and 1, 3, and 6 months after surgery.
  
  
  RESULTS
  The final analysis included 33 eyes in the PKP group and 24 eyes in the DALK group. In the PKP group, the central macula was found to be 6.5%, 6.3%, and 4.5% thicker in the first, third, and sixth month, respectively. Similarly, the central macula was 5.6%, 5.4%, and 2.9% thicker at months 1, 3, and 6 in the DALK group. The 2 groups did not differ significantly in terms of macular thickening. The percentage of eyes showing more than 10% increase in the macular region at any time during the follow-up period was 43.2% in the PKP group and 50.0% in the DALK group (P = 0.614). The percentage of eyes found to have a central macular thickness more than 250 μm at any time during the follow-up period was 10.8% in the PKP group and 18.2% in the DALK group (P = 0.424).
  
  
  CONCLUSIONS
  The study showed that DALK, although it is a closed-system technique, has a similar impact on the macula compared with PKP.
authors: Department of Ophthalmology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey. akoytak@yahoo.com
authors: Arif
authors: A
authors: Koytak
authors: Anil
authors: A
authors: Kubaloglu
authors: Esin Sogutlu
authors: ES
authors: Sari
authors: Mehmet
authors: M
authors: Atakan
authors: Safak
authors: S
authors: Culfa
authors: Yusuf
authors: Y
authors: Ozerturk
mesh_terms: D000293:Adolescent; D000328:Adult; D016039:Corneal Transplantation / Q000379:methods*; D005260:Female; D006801:Humans; D007640:Keratoconus / Q000503:physiopathology / Q000601:surgery*; D015948:Keratoplasty, Penetrating / Q000379:methods*; D008266:Macula Lutea / Q000473:pathology*; D008269:Macular Edema / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods; D014792:Visual Acuity; D055815:Young Adult