title: Stool pattern changes in toddlers consuming a follow-on formula supplemented with polydextrose and galactooligosaccharides.
abstract: Healthy 9- to 48-month-old children (n = 133) were randomized to receive a cow's-milk-based follow-on formula (control) or the same formula with polydextrose and galactooligosaccharides (PDX/GOS) for 108 days. Pediatricians assessed diarrheal disease, stool pattern, acute respiratory infection, systemic antibiotic use, and growth. The 2 groups had similar weight-for-length/height z score and similar odds of having diarrheal disease, acute respiratory infection, and systemic antibiotic use; however, PDX/GOS had greater odds of increased defecation than control (P ≤ 0.01). Addition of PDX and GOS to a follow-on formula was well tolerated and induced a pattern of more frequent and softer stools in toddlers.
authors: Department of Pediatrics, Fima Lifshitz Research Center, University Hospital Complex Professor Edgard Santos, Federal University of Bahia, Salvador, Brazil.
authors: Tereza C M
authors: TC
authors: Ribeiro
authors: Hugo
authors: H
authors: Costa-Ribeiro
authors: Patricia S
authors: PS
authors: Almeida
authors: Mariana V
authors: MV
authors: Pontes
authors: Maria E Q
authors: ME
authors: Leite
authors: Lais R
authors: LR
authors: Filadelfo
authors: Jane C
authors: JC
authors: Khoury
authors: Judy A
authors: JA
authors: Bean
authors: Susan H
authors: SH
authors: Mitmesser
authors: Jon A
authors: JA
authors: Vanderhoof
authors: Deolinda M F
authors: DM
authors: Scalabrin
mesh_terms: D000208:Acute Disease; D000818:Animals; D002675:Child, Preschool; D003248:Constipation / Q000517:prevention & control; D003672:Defecation / Q000187:drug effects*; D003967:Diarrhea / Q000517:prevention & control*; D004311:Double-Blind Method; D005260:Female; D005936:Glucans / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007223:Infant; D041943:Infant Formula / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D008892:Milk; D009844:Oligosaccharides / Q000008:administration & dosage / Q000494:pharmacology*; D056692:Prebiotics; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012141:Respiratory Tract Infections / Q000517:prevention & control*
chemical_list: D005936:Glucans; D009844:Oligosaccharides; D056692:Prebiotics; C033375:polydextrose