title: Surgical management of gastric perforation in the setting of gastric cancer.
abstract: BACKGROUND
  Gastric perforation is a rare presentation of gastric cancer and is thought to be a predictor of advanced disease and, thus, poor prognosis. Guidelines do not exist for the optimal management strategy. We aimed to identify, review, and summarize the literature pertaining to perforation in the setting of gastric cancer.
  
  
  METHODS
  A qualitative, systematic review of the literature was performed from January 1, 1985, to January 1, 2010. Searches of MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were performed using search terms related to gastric cancer surgery. Abstracts were examined by two independent reviewers and a standardized data collection tool was used to extract relevant data points. Summary tables were created.
  
  
  RESULTS
  Nine articles were included. Perforation was reported to occur in fewer than 5% of gastric cancer patients. Preoperative diagnosis of a gastric cancer was rated and occurred in 14-57% of patients in the papers reviewed. Mortality rates for emergency gastrectomy ranged from 0 to 50% and for simple closure procedures the rates ranged from 8 to 100%. Patients able to receive an R0 gastrectomy demonstrated better long-term survival (median 75 months, 50% 5-year) compared with patients who had simple closure procedures.
  
  
  CONCLUSIONS
  Gastric cancer patients presenting with a gastric perforation demonstrate improved overall survival with an R0 resection; however, implementation of this management technique is complicated by infrequent preoperative gastric cancer diagnosis, and inability to perform an oncologic resection due to patient instability and intra-abdominal contamination.
authors: Department of Community Health and Epidemiology, Queen's University, Kingston, Canada.
authors: Alyson L
authors: AL
authors: Mahar
authors: Savtaj S
authors: SS
authors: Brar
authors: Natalie G
authors: NG
authors: Coburn
authors: Calvin
authors: C
authors: Law
authors: Lucy K
authors: LK
authors: Helyer
mesh_terms: D004630:Emergencies; D005743:Gastrectomy / Q000379:methods* / Q000401:mortality; D006801:Humans; D017410:Practice Guidelines as Topic; D011379:Prognosis; D012422:Rupture, Spontaneous / Q000453:epidemiology / Q000209:etiology / Q000601:surgery; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D013275:Stomach Rupture / Q000453:epidemiology / Q000209:etiology / Q000601:surgery*; D015996:Survival Rate; D016896:Treatment Outcome