title: Placental protein 13 and decidual zones of necrosis: an immunologic diversion that may be linked to preeclampsia.
abstract: We evaluated the role of placental protein 13 (PP13; galectin 13) in the process of trophoblast invasion and decidual necrosis. Immunohistochemical analysis for PP13, immune cells, human placental lactogen, cytokeratin, and apoptosis markers was performed on 20 elective pregnancy termination specimens between 6 and 15 weeks of gestation. Placental protein 13 was localized to syncytiotrophoblasts in the chorionic villi and to occasional multinucleated luminal trophoblasts within converted decidual spiral arterioles. Cytotrophoblasts, anchoring trophoblasts, and invasive trophoblasts did not stain for PP13. Extracellular PP13 aggregates were found around decidual veins associated with T-cell-, neutrophil- and macrophage-containing decidual zones of necrosis (ZONEs). We hypothesize that PP13 is secreted into the intervillus space, drains through the decidua basalis veins, and forms perivenous PP13 aggregates which attract and activate maternal immune cells. Thus, syncytiotrophoblast-derived PP13 may create a ZONE that facilitates trophoblast invasion and conversion of the maternal spiral arterioles.
authors: Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, New Haven, CT 06520, USA. harvey.kliman@yale.edu
authors: Harvey J
authors: HJ
authors: Kliman
authors: M
authors: M
authors: Sammar
authors: Y I
authors: YI
authors: Grimpel
authors: S K
authors: SK
authors: Lynch
authors: K M
authors: KM
authors: Milano
authors: E
authors: E
authors: Pick
authors: J
authors: J
authors: Bejar
authors: A
authors: A
authors: Arad
authors: J J
authors: JJ
authors: Lee
authors: H
authors: H
authors: Meiri
authors: R
authors: R
authors: Gonen
mesh_terms: D000293:Adolescent; D000328:Adult; D003656:Decidua / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D037161:Galectins / Q000097:blood* / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D009336:Necrosis / Q000097:blood / Q000276:immunology / Q000473:pathology; D010920:Placenta / Q000098:blood supply / Q000378:metabolism / Q000473:pathology; D011225:Pre-Eclampsia / Q000276:immunology / Q000378:metabolism* / Q000473:pathology*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood* / Q000378:metabolism; D014327:Trophoblasts / Q000276:immunology / Q000378:metabolism; D055815:Young Adult
chemical_list: D037161:Galectins; C038195:LGALS13 protein, human; D011257:Pregnancy Proteins