title: 14-3-3 proteins as potential therapeutic targets.
abstract: The 14-3-3 family of phosphoserine/phosphothreonine-binding proteins dynamically regulates the activity of client proteins in various signaling pathways that control diverse physiological and pathological processes. In response to environmental cues, 14-3-3 proteins orchestrate the highly regulated flow of signals through complex networks of molecular interactions to achieve well-controlled physiological outputs, such as cell proliferation or differentiation. Accumulating evidence now supports the concept that either an abnormal state of 14-3-3 protein expression, or dysregulation of 14-3-3/client protein interactions, contributes to the development of a large number of human diseases. In particular, clinical investigations in the field of oncology have demonstrated a correlation between upregulated 14-3-3 levels and poor survival of cancer patients. These studies highlight the rapid emergence of 14-3-3 proteins as a novel class of molecular target for potential therapeutic intervention. The current status of 14-3-3 modulator discovery is discussed.
authors: Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA. zhaojing@fmmu.edu.cn
authors: Jing
authors: J
authors: Zhao
authors: Cheryl L
authors: CL
authors: Meyerkord
authors: Yuhong
authors: Y
authors: Du
authors: Fadlo R
authors: FR
authors: Khuri
authors: Haian
authors: H
authors: Fu
mesh_terms: D048948:14-3-3 Proteins / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000378:metabolism*; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D002454:Cell Differentiation; D049109:Cell Proliferation; D055808:Drug Discovery; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology*; D011485:Protein Binding; D015398:Signal Transduction
chemical_list: D048948:14-3-3 Proteins; D002352:Carrier Proteins