title: Transcription of Aspergillus nidulans pacC is modulated by alternative RNA splicing of palB.
abstract: Fungi have evolved elaborate signal transduction networks for remodeling metabolic pathways to scavenge nutrients, including the secretion of nutritional enzymes. This adaptive response involves the conserved PacC/Pal signal transduction pathway, which mediates the transcriptional response to ambient pH. In this study, we show that transcription of the gene for PacC is modulated in response to nutrient changes, phosphate and carbon sources, and pH. In addition, we show that transcription of pacC is modulated in response to alternative RNA splicing of the palB gene. These results reveal novel aspects of the complex network involved in modulation of pacC.
authors: Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14049-900 Ribeirão Preto, SP, Brazil.
authors: Glauce L
authors: GL
authors: Trevisan
authors: Ernna H D
authors: EH
authors: Oliveira
authors: Nalu T A
authors: NT
authors: Peres
authors: Aline H S
authors: AH
authors: Cruz
authors: Nilce M
authors: NM
authors: Martinez-Rossi
authors: Antonio
authors: A
authors: Rossi
mesh_terms: D017398:Alternative Splicing / Q000187:drug effects / Q000235:genetics*; D001233:Aspergillus nidulans / Q000187:drug effects / Q000235:genetics*; D002244:Carbon / Q000494:pharmacology; D003546:Cysteine Endopeptidases / Q000172:deficiency / Q000235:genetics*; D005656:Fungal Proteins / Q000235:genetics*; D015966:Gene Expression Regulation, Fungal / Q000187:drug effects / Q000235:genetics; D006863:Hydrogen-Ion Concentration; D009154:Mutation; D010710:Phosphates / Q000494:pharmacology; D060888:Real-Time Polymerase Chain Reaction; D014157:Transcription Factors / Q000235:genetics*; D014158:Transcription, Genetic / Q000187:drug effects / Q000235:genetics*
chemical_list: D005656:Fungal Proteins; C092394:PacC protein, Aspergillus; D010710:Phosphates; D014157:Transcription Factors; D002244:Carbon; D003546:Cysteine Endopeptidases; C097042:PalB protein, Aspergillus nidulans