title: Role of cellular lipids in positive-sense RNA virus replication complex assembly and function.
abstract: Positive-sense RNA viruses are responsible for frequent and often devastating diseases in humans, animals, and plants. However, the development of effective vaccines and anti-viral therapies targeted towards these pathogens has been hindered by an incomplete understanding of the molecular mechanisms involved in viral replication. One common feature of all positive-sense RNA viruses is the manipulation of host intracellular membranes for the assembly of functional viral RNA replication complexes. This review will discuss the interplay between cellular membranes and positive-sense RNA virus replication, and will focus specifically on the potential structural and functional roles for cellular lipids in this process.
authors: Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA.
authors: Kenneth A
authors: KA
authors: Stapleford
authors: Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.|Department of Microbiology & Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
authors: David J
authors: DJ
authors: Miller