title: Hepatoprotective action of Radix Paeoniae Rubra aqueous extract against CCl4-induced hepatic damage.
abstract: In the present study the capacity of Radix Paeoniae Rubra aqueous extract (RPRAE) as an antioxidant to protect against carbon tetrachloride (CCl(4))-induced oxidative stress and hepatotoxicity in Wistar rats was investigated. Six groups of rats were used. Radix Paeoniae Rubra aqueous extract (100 or 200 or 300 mg/kg of bw) or bifendate (100 mg/kg of bw) were given daily by gavage to the animals on 28 consecutive days to elucidate the protective effects against CCl(4)-induced hepatotoxicity. The 20% CCl(4)/olive oil was gavage of gastric tube twice a week (on the third and seventh days of each week). The animals of normal control group were given only vehicle. The animals of CCl(4)-treated group were administered with CCl(4) twice a week (on the third and seventh days of each week) and with vehicle on rest of the days. The test materials were found effective as hepatoprotective agents, as evidenced by plasma and liver biochemical parameters. Therefore, the results of this study show that Radix Paeoniae Rubra aqueous extract can protect the liver against CCl(4)-induced oxidative damage in rats, and the hepatoprotective effects might be correlated with its antioxidant and free radical scavenger effects.
authors: Department of Organ Transplantation, Changzheng Hospital, The Second Military Medical University, Shanghai, China. rdliczsh@yahoo.com.cn
authors: Ruidong
authors: R
authors: Li
authors: Wenyuan
authors: W
authors: Guo
authors: Zhiren
authors: Z
authors: Fu
authors: Guoshan
authors: G
authors: Ding
authors: You
authors: Y
authors: Zou
authors: Zhengxin
authors: Z
authors: Wang
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology; D002251:Carbon Tetrachloride; D002252:Carbon Tetrachloride Poisoning; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D029596:Paeonia / Q000378:metabolism*; D008517:Phytotherapy; D018517:Plant Roots / Q000737:chemistry; D020011:Protective Agents / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D004365:Drugs, Chinese Herbal; D020011:Protective Agents; C465548:bifendate; D002251:Carbon Tetrachloride