title: Medication Exposure in Pregnancy Risk Evaluation Program.
abstract: To describe a program to study medication safety in pregnancy, the Medication Exposure in Pregnancy Risk Evaluation Program (MEPREP). MEPREP is a multi-site collaborative research program developed to enable the conduct of studies of medication use and outcomes in pregnancy. Collaborators include the U.S. Food and Drug Administration and researchers at the HMO Research Network, Kaiser Permanente Northern and Southern California, and Vanderbilt University. Datasets have been created at each site linking healthcare data for women delivering an infant between January 1, 2001 and December 31, 2008 and infants born to these women. Standardized data files include maternal and infant characteristics, medication use, and medical care at 11 health plans within 9 states; birth certificate data were obtained from the state departments of public health. MEPREP currently involves more than 20 medication safety researchers and includes data for 1,221,156 children delivered to 933,917 mothers. Current studies include evaluations of the prevalence and patterns of use of specific medications and a validation study of data elements in the administrative and birth certificate data files. MEPREP can support multiple studies by providing information on a large, ethnically and geographically diverse population. This partnership combines clinical and research expertise and data resources to enable the evaluation of outcomes associated with medication use during pregnancy.
authors: Meyers Primary Care Institute, 630 Plantation St., Worcester, MA 01605, USA. sandrade@meyersprimary.org
authors: Susan E
authors: SE
authors: Andrade
authors: Robert L
authors: RL
authors: Davis
authors: T Craig
authors: TC
authors: Cheetham
authors: William O
authors: WO
authors: Cooper
authors: De-Kun
authors: DK
authors: Li
authors: Thushi
authors: T
authors: Amini
authors: Sarah J
authors: SJ
authors: Beaton
authors: Sascha
authors: S
authors: Dublin
authors: Tarek A
authors: TA
authors: Hammad
authors: Pamala A
authors: PA
authors: Pawloski
authors: Marsha A
authors: MA
authors: Raebel
authors: David H
authors: DH
authors: Smith
authors: Judy A
authors: JA
authors: Staffa
authors: Sengwee
authors: S
authors: Toh
authors: Inna
authors: I
authors: Dashevsky
authors: Katherine
authors: K
authors: Haffenreffer
authors: Kimberly
authors: K
authors: Lane
authors: Richard
authors: R
authors: Platt
authors: Pamela E
authors: PE
authors: Scott
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001719:Birth Certificates; D003299:Cooperative Behavior; D003625:Data Collection / Q000379:methods; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008498:Medical Record Linkage / Q000379:methods; D008875:Middle Aged; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D017891:Pharmacoepidemiology / Q000379:methods*; D011159:Population Surveillance; D011247:Pregnancy; D011256:Pregnancy Outcome; D018570:Risk Assessment; D055815:Young Adult
chemical_list: D004364:Pharmaceutical Preparations