title: Sublethal effects of waterborne herbicides in tropical freshwater fish.
abstract: The study evaluated the sublethal effects of the herbicides glyphosate (Roundup) and diuron (Hexaron) and the mixture of them, used extremely in agriculture, through biomarkers in fish. The glutathione S-transferase activity increased (74%) and catalase activity decreased (37%) at the higher exposure concentration of Hexaron in comparison to the control group, suggesting an activation of this metabolism route. Membrane damage was observed at the higher exposure of Roundup and in the mixture group compared to the control group, which can be related to the nuclear alterations observed in these exposed groups. The cholinesterase activity was also inhibited (37%) in mixture group compared to the control group and no gill morphology damage was found. The results suggested a potential synergic effect in some analysed parameters.
authors: Department of Pharmacology, Federal University of Paraná, PO Box 19031, Curitiba, PR, 81.531-990, Brazil.
authors: Stéfani Cibele
authors: SC
authors: Rossi
authors: Manuela
authors: M
authors: Dreyer da Silva
authors: Laercio Dante Stein
authors: LD
authors: Piancini
authors: Ciro Alberto
authors: CA
authors: Oliveira Ribeiro
authors: Marta Margarete
authors: MM
authors: Cestari
authors: Helena Cristina
authors: HC
authors: Silva de Assis
mesh_terms: D000818:Animals; D015415:Biomarkers; D002374:Catalase / Q000378:metabolism; D060126:Characidae / Q000378:metabolism*; D002802:Cholinesterases / Q000378:metabolism; D004237:Diuron / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004784:Environmental Monitoring / Q000379:methods; D005618:Fresh Water / Q000737:chemistry*; D005982:Glutathione Transferase / Q000378:metabolism; D005998:Glycine / Q000031:analogs & derivatives / Q000633:toxicity; D006540:Herbicides / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D000097797:Glyphosate
chemical_list: D015415:Biomarkers; D002374:Catalase; D002802:Cholinesterases; D004237:Diuron; D005982:Glutathione Transferase; D005998:Glycine; D006540:Herbicides; D014874:Water Pollutants, Chemical; D000097797:Glyphosate