title: Incidence and seroprevalence of dengue virus infections in Australian travellers to Asia.
abstract: The purpose of this study was to estimate the incidence density and prevalence of dengue virus infection in Australian travellers to Asia. We conducted a multi-centre prospective cohort study of Australian travellers over a 32-month period. We recruited 467 travellers (≥ 16 years of age) from three travel clinics who intended to travel Asia, and 387 (82.9%) of those travellers completed questionnaires and provide samples pre- and post-travel for serological testing for dengue virus infection. Demographic data, destination countries and history of vaccinations and flavivirus infections were obtained. Serological testing for dengue IgG and IgM by enzyme-linked immunosorbent assay (ELISA) (PanBio assay) was performed. Acute seroconversion for dengue infection was demonstrated in 1.0% of travellers, representing an incidence of 3.4 infections per 10,000 days of travel (95% confidence interval [CI]: 0.9-8.7). The seroprevalence of dengue infection was 4.4% and a greater number of prior trips to Asia was a predictor for dengue seroprevalence (p = 0.019). All travellers experienced subclinical dengue infections and had travelled to India (n = 3) and China (n = 1). This significant attack rate of dengue infection can be used to advise prospective travellers to dengue-endemic countries.
authors: The Royal Melbourne Hospital, Parkville, VIC, Australia.
authors: I
authors: I
authors: Ratnam
authors: J
authors: J
authors: Black
authors: K
authors: K
authors: Leder
authors: B-A
authors: BA
authors: Biggs
authors: E
authors: E
authors: Matchett
authors: A
authors: A
authors: Padiglione
authors: I
authors: I
authors: Woolley
authors: T
authors: T
authors: Panagiotidis
authors: T
authors: T
authors: Gherardin
authors: L
authors: L
authors: Pollissard
authors: C
authors: C
authors: Demont
authors: C
authors: C
authors: Luxemburger
authors: J
authors: J
authors: Torresi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D001208:Asia; D001315:Australia / Q000453:epidemiology; D015331:Cohort Studies; D003715:Dengue / Q000453:epidemiology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016036:Seroepidemiologic Studies; D011795:Surveys and Questionnaires; D014195:Travel; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M