title: Acute cellular rejection resulting in sinusoidal obstruction syndrome and ascites postliver transplantation.
abstract: BACKGROUND
  The cause of ascites formation postliver transplantation (LT) is multifactorial. Sinusoidal obstruction syndrome (SOS) is a rare cause of ascites post-LT and has been reported to occur as a sequela of acute cellular rejection (ACR). We sought to examine the histologic features of patients developing ascites in the setting of ACR.
  
  
  METHODS
  By using the pathology database, we identified five patients with ACR who had ascites and 10 control patients with severe ACR without ascites. Features of SOS such as congestion, central venulitis, and hepatocyte necrosis were scored (zero absent, one mild, two moderate, and three severe) and perivenular fibrosis (zero absent, one mild, two fibrous septa present, three bridging fibrous septa, and four numerous septa with architectural distortion). Rejection activity index (Banff criteria) was determined. Clinical, biochemical and outcome information were obtained from chart review.
  
  
  RESULTS
  All five ascites patient had histologic evidence of SOS. Statistical significance was noted between the ascites and control groups for perivenular fibrosis score (3.6 vs. 0.8, P=0.0004), congestion (3 vs. 1.2, P=0.000005), and central venulitis (3 vs. 1.7, P=0.002). All patients in the ascites group required re-LT or died whereas all control patients remain alive. No significant statistical difference was noted with donor age despite the mean being older in the ascites group (52.8 vs. 35.8 years).
  
  
  CONCLUSIONS
  ACR resulting in SOS and associated with significant perivenular fibrosis, central venulitis and congestion may be the cause of ascites post-LT and may portend a poor prognosis for recovery.
authors: Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Mohammad Hossein
authors: MH
authors: Sanei
authors: Thomas D
authors: TD
authors: Schiano
authors: Christine
authors: C
authors: Sempoux
authors: Cathy
authors: C
authors: Fan
authors: M Isabel
authors: MI
authors: Fiel
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D001201:Ascites / Q000209:etiology*; D005260:Female; D006084:Graft Rejection; D006504:Hepatic Veno-Occlusive Disease / Q000209:etiology*; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged