title: Minor labdane diterpenes from Marrubium thessalum.
abstract: Five new labdane diterpenes, thessalines A, B, and D, 14β-hydroxythessaline A, and 14β-hydroxythessaline B (1-5, resp.) were isolated from the aerial parts of Marrubium thessalum, along with the known labdane diterpene deacetylvitexilactone (6) and the methoxylated flavones 4',7-dimethylapigenin and salvigenin. (3S,5R)-Loliolide was also found in the same source. Their structures were established by 1D- and 2D-NMR (COSY, HSQC, HMBC, NOESY, and ROESY) and MS analyses. The plant produces a great variety of labdane-type diterpenes, with variations in functionalities, particularly in the side chain. Their structures could be of chemotaxonomic significance for the genus Marrubium.
authors: Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, GR-15771, Athens.
authors: Catherine
authors: C
authors: Argyropoulou
authors: Anastasia
authors: A
authors: Karioti
authors: Helen
authors: H
authors: Skaltsa
mesh_terms: D001572:Benzofurans / Q000737:chemistry; D004224:Diterpenes / Q000737:chemistry*; D047309:Flavones / Q000737:chemistry; D027522:Marrubium / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D001572:Benzofurans; D004224:Diterpenes; D047309:Flavones; C014049:salvigenin; C030425:loliolide