title: Neuronal action on the developing blood vessel pattern.
abstract: The nervous system relies on a highly specialized network of blood vessels for development and neuronal survival. Recent evidence suggests that both the central and peripheral nervous systems (CNS and PNS) employ multiple mechanisms to shape the vascular tree to meet its specific metabolic demands, such as promoting nerve-artery alignment in the PNS or the development the blood brain barrier in the CNS. In this article we discuss how the nervous system directly influences blood vessel patterning resulting in neuro-vascular congruence that is maintained throughout development and in the adult.
authors: Laboratory of Stem Cell and Neuro-Vascular Biology, Genetics and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10/6C103, 10 Center Drive, Bethesda, MD 20892, United States.
authors: Jennifer M
authors: JM
authors: James
authors: Yoh-suke
authors: YS
authors: Mukouyama
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000294:innervation*; D001812:Blood-Brain Barrier; D001921:Brain / Q000098:blood supply*; D006801:Humans; D009024:Morphogenesis / Q000502:physiology; D009420:Nervous System / Q000098:blood supply*; D009474:Neurons / Q000502:physiology*