title: Magnetic resonance imaging relaxation time measurements of the placenta at 1.5 T.
abstract: Placental insufficiency is a major cause of fetal growth restriction (FGR) and accumulating evidence indicates several aspects of placental morphology are altered in this condition. MRI provides quantitative indices that may be used in non-invasive assessment of the human placenta, such as relaxation time measurements, T1 and T2. We hypothesised that placental relaxation times relate to alterations in placental tissue morphology and hence may be useful in identifying the changes associated with FGR. We report on the first phase of testing this hypothesis, in a study of women in normal pregnancy.
  
  
  OBJECTIVE
  To assess relaxation time measurements in the placenta in normal pregnancy and correlate these with gestational age and stereological analyses of placental morphology following delivery.
  
  
  METHODS
  30 women underwent MRI examination (1.5 T) between 20 and 41 weeks gestation. Placental T1 and T2 measurements were acquired from a mid-depth placental region, co-localised to a structural scan. Fixed, wax-embedded sections of these placentas collected at delivery were stained with hematoxylin/eosin and subjected to stereological analysis.
  
  
  RESULTS
  Placental T1 and T2 show a significant negative correlation with gestation, (Pearson correlation p=0.01, 0.03 respectively). 17 placentas were analysed stereologically. In the group as a whole there was no significant correlation between T1 and T2 and morphological features. However, in a subset of 7 pregnancies scanned within a week of delivery, a significant positive correlation was observed between the fibrin volume density and the ratio of fibrin: villous volume densities and T2 (Spearman correlation p=0.02, 0.03 respectively).
  
  
  CONCLUSIONS
  The correlations between placental T1 and T2 and gestation show that these variables are clearly influenced by changes in placental structure. Fibrin might be a key component but further work is needed to fully elucidate the major structural influences on placental T1 and T2.
authors: Maternal & Fetal Health Research Centre, University of Manchester, M13 9WL, UK. carolinewright@doctors.org.uk
authors: C
authors: C
authors: Wright
authors: D M
authors: DM
authors: Morris
authors: P N
authors: PN
authors: Baker
authors: I P
authors: IP
authors: Crocker
authors: P A
authors: PA
authors: Gowland
authors: G J
authors: GJ
authors: Parker
authors: C P
authors: CP
authors: Sibley
mesh_terms: D005260:Female; D005317:Fetal Growth Retardation / Q000473:pathology*; D005337:Fibrin / Q000032:analysis; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010920:Placenta / Q000737:chemistry / Q000473:pathology*; D010927:Placental Insufficiency / Q000473:pathology; D011247:Pregnancy
chemical_list: D005337:Fibrin