title: Synthesis and SAR of 2-phenoxypyridines as novel c-Jun N-terminal kinase inhibitors.
abstract: The design and synthesis of a novel series of c-jun N-terminal kinase (JNK3) inhibitors is described. The development and optimization of the 2-phenoxypyridine series was carried out from an earlier pyrimidine series of JNK1 inhibitors. Through the optimization of the scaffold 2, several potent compounds with good in vivo profiles were discovered.
authors: Department of Molecular Therapeutics and Translational Research Institute, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA.
authors: Xinyi
authors: X
authors: Song
authors: Weimin
authors: W
authors: Chen
authors: Li
authors: L
authors: Lin
authors: Claudia H
authors: CH
authors: Ruiz
authors: Michael D
authors: MD
authors: Cameron
authors: Derek R
authors: DR
authors: Duckett
authors: Theodore M
authors: TM
authors: Kamenecka
mesh_terms: D015195:Drug Design; D004789:Enzyme Activation / Q000187:drug effects; D020128:Inhibitory Concentration 50; D048031:JNK Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors*; D008958:Models, Molecular; D015394:Molecular Structure; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D047428:Protein Kinase Inhibitors; D011725:Pyridines; D011743:Pyrimidines; D048031:JNK Mitogen-Activated Protein Kinases