title: Cannabis in sport: anti-doping perspective.
abstract: Since 2004, when the World Anti-Doping Agency assumed the responsibility for establishing and maintaining the list of prohibited substances and methods in sport (i.e. the Prohibited List), cannabinoids have been prohibited in all sports during competition. The basis for this prohibition can be found in the World Anti-Doping Code, which defines the three criteria used to consider banning a substance. In this context, we discuss the potential of cannabis to enhance sports performance, the risk it poses to the athlete's health and its violation of the spirit of sport. Although these compounds are prohibited in-competition only, we explain why the pharmacokinetics of their main psychoactive compound, Δ(9)-tetrahydrocannabinol, may complicate the results management of adverse analytical findings. Passive inhalation does not appear to be a plausible explanation for a positive test. Although the prohibition of cannabinoids in sports is one of the most controversial issues in anti-doping, in this review we stress the reasons behind this prohibition, with strong emphasis on the evolving knowledge of cannabinoid pharmacology.
authors: Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA. mhuestis@intra.nida.nih.gov
authors: Marilyn A
authors: MA
authors: Huestis
authors: Irene
authors: I
authors: Mazzoni
authors: Olivier
authors: O
authors: Rabin
mesh_terms: D002186:Cannabinoids / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology*; D002188:Cannabis; D003163:Competitive Behavior; D004300:Doping in Sports / Q000331:legislation & jurisprudence / Q000517:prevention & control; D006801:Humans
chemical_list: D002186:Cannabinoids