title: First description of an olfactory neuroblastoma in goldfish Carassius auratus: a case report.
abstract: An external pinkish growing mass that emerged from the right nostril of an adult goldfish Carassius auratus L. was evaluated by means of light microscopy and immunohistochemistry. The neoplasm presented a well-developed fibrovascular stroma associated with solid cell nests and a large number of Flexner-Wintersteiner rosettes. Myelinated fibres were observed around them. Neoplastic cells showed a prominent degree of nuclear atypia and low mitotic activity. The latter was in agreement with the low reactivity of tumour cells to anti-proliferating cell nuclear antigen antibody. Immunohistochemistry also revealed anti-neuronal nitric oxide synthase, anti-S100 protein, antineuropeptide Y, and anti-cytokeratin immunoreactivity in tumour cells as well as in normal olfactory epithelium of goldfish control sections. Histopathological and immunohistochemical findings strongly suggest a diagnosis of an olfactory neuroblastoma (ONB). To our knowledge this is the first description of ONB in goldfish.
authors: Cátedra de Histología y Embriología, Facultad de Ciencias Veterinarias, Universidad Nacional de Rosario, S2170HGJ Casilda, Argentina. fviglian@fveter.unr.edu.ar
authors: F A
authors: FA
authors: Vigliano
authors: A J
authors: AJ
authors: Marcaccini
authors: J
authors: J
authors: Sarradell
authors: R
authors: R
authors: Bermúdez
authors: M I
authors: MI
authors: Quiroga
mesh_terms: D000818:Animals; D005393:Fish Diseases / Q000473:pathology*; D006054:Goldfish; D009447:Neuroblastoma / Q000473:pathology / Q000662:veterinary*; D009669:Nose Neoplasms / Q000473:pathology / Q000662:veterinary*