title: [A case of drug-induced eosinophilic pneumonia due to tegafur-uracil(UFT®)].
abstract: A 68-year-old female received a left lower lobectomy for lung cancer (adenocarcinoma, pT2N1M0, stage II B). She had a postoperative bronchial fistula that was treated conservatively and cured. Two months after the operation, tegafur-uracil (UFT) 300 mg/day was initiated.She felt dyspnea on exertion after taking UFT for two weeks, and some infiltration shadows were observed on a chest X-ray two weeks later. A chest CT scan revealed unsegmental infiltration shadows at the intermediate areas of the right middle and lower lobes, and an air-bronchogram was observed inside of the shadows. A bronchoscopy was performed. Bronchoalveolar lavage revealed a high fraction rate of eosinophil(24%), and a transbronchial lung biopsy revealed infiltrations of lymphocytes, eosinophils and neutrophils into the intra-alveolar space. However, fibrosis of the alveolar wall was not observed. A drug-induced lymphocyte stimulation test was performed for UFT, resulting positive. She was diagnosed as drug-induced eosinopilic pneumonia due to UFT. After she discontinued UFT and started 30 mg/day of prednisolone, dyspnea and infiltrations on chest X-ray disappeared.
authors: Department of Surgery, Himeji Red Cross Hospital, Japan.
authors: Itaru
authors: I
authors: Nagahiro
authors: Manabu
authors: M
authors: Miyamoto
authors: Hironobu
authors: H
authors: Sugiyama
authors: Tsuyoshi
authors: T
authors: Kawai
authors: Keisuke
authors: K
authors: Toda
authors: Tetsuharu
authors: T
authors: Nobuhisa
authors: Yoshikatsu
authors: Y
authors: Endou
authors: Takanori
authors: T
authors: Watanabe
authors: Yusuke
authors: Y
authors: Matsumoto
authors: Naoki
authors: N
authors: Watanabe
authors: Kyohei
authors: K
authors: Kai
authors: Shizou
authors: S
authors: Satou
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D000077192:Adenocarcinoma of Lung; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D009367:Neoplasm Staging; D011657:Pulmonary Eosinophilia / Q000139:chemically induced*; D005641:Tegafur / Q000009:adverse effects / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D014498:Uracil / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D005641:Tegafur; D014498:Uracil