title: Innate immune response gene expression profiles in central nervous system of mice infected with rabies virus.
abstract: The present study was focused on the modulation of innate immune response genes in CNS of mouse in response to rabies virus (RABV) infection. The global gene expression changes in brains of RABV- or mock-infected mice were investigated using DNA microarray analysis and quantitative real-time PCR. Then functional enrichment of the differentially expressed mRNAs was performed. Microarray analysis showed that 390 genes in brain were significantly (P<0.01) regulated in response to RABV infection, with obviously up-regulated genes like interferon (IFN) stimulated genes (ISGs), IFN inducible transcription factors, cytokines and complement, etc. The significant pathways of differentially expressed genes are mainly involved in JAK-STAT signaling pathway, antigen processing and presentation, ubiquitin mediated proteolysis and complement cascades. The results suggest that the modulated genes in infected CNS were possibly involved in pathogenesis of rabies. Conversely, they may have protective effects.
authors: Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China. zhaopingsen@hotmail.com
authors: Pingsen
authors: P
authors: Zhao
authors: Lili
authors: L
authors: Zhao
authors: Tao
authors: T
authors: Zhang
authors: Yinglin
authors: Y
authors: Qi
authors: Tiecheng
authors: T
authors: Wang
authors: Kejian
authors: K
authors: Liu
authors: Hualei
authors: H
authors: Wang
authors: Hao
authors: H
authors: Feng
authors: Hongli
authors: H
authors: Jin
authors: Chuan
authors: C
authors: Qin
authors: Songtao
authors: S
authors: Yang
authors: Xianzhu
authors: X
authors: Xia
mesh_terms: D000818:Animals; D001921:Brain / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D020805:Central Nervous System Viral Diseases / Q000235:genetics* / Q000276:immunology*; D016000:Cluster Analysis; D005260:Female; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D007113:Immunity, Innate / Q000235:genetics*; D051379:Mice; D008807:Mice, Inbred BALB C; D011818:Rabies / Q000235:genetics* / Q000276:immunology*; D011820:Rabies virus / Q000302:isolation & purification*; D015398:Signal Transduction; D019562:Viral Load