title: Kidney injury molecule-1 correlates with kidney function in heart allograft recipients.
abstract: Serum creatinine and estimated glomerular filtration rate (eGFR) (24 hours creatinine clearance, Modification of Diet in Renal Disease, Chronic Kidney Disease Epidemiology Collaboration, Cockcroft-Gault formulae), and urinary kidney injury molecule-1 (KIM-1), were evaluated in 111 heart allograft recipients on therapy with a calcineurin inhibitor, mycophenolate mofetil or azathioprine plus prednisone. KIM-1 was assessed using commercially available assay. Normotensive heart allograft recipients showed significantly lower KIM-1 values than hypertensive subjects. Urinary KIM-1 was significantly higher among New York Heart Association class III versus I and II patients. Upon univariate analysis, urinary KIM-1 strongly correlated with serum creatinine (r=.54) and eGFR (r=.66) but only weakly with other parameters. It was not related to cystatin C. Upon multiple regression analysis, the best predictor of urinary KIM-1 was eGFR (beta -0.56), explaining 76% of KIM-1 concentrations. Even a successful heart transplantation is associated with kidney injury as reflected by elevated urinary KIM-1 and reduced eGFR. Therefore, KIM-1 needs to be investigated as a potential early marker for impaired kidney function/kidney injury, especially in patients with other risk factor for kidney damage, for example, hypertension or congestive heart failure.
authors: Department of Cardiovasvular Surgery and Transplantology, Collegium Medicum, Jagiellonian University, John Paul II Hospital, Krakow, Poland. piotrus@aol.com
authors: P
authors: P
authors: Przybylowski
authors: J
authors: J
authors: Malyszko
authors: S
authors: S
authors: Kozlowska
authors: J S
authors: JS
authors: Malyszko
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000652:urine; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D016027:Heart Transplantation / Q000009:adverse effects* / Q000502:physiology*; D000072596:Hepatitis A Virus Cellular Receptor 1; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000652:urine; D007668:Kidney / Q000293:injuries* / Q000503:physiopathology; D007677:Kidney Function Tests / Q000379:methods*; D008297:Male; D008562:Membrane Glycoproteins / Q000652:urine*; D008875:Middle Aged; D011991:Receptors, Virus; D051436:Renal Insufficiency, Chronic / Q000209:etiology / Q000652:urine
chemical_list: D015415:Biomarkers; C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; D008562:Membrane Glycoproteins; D011991:Receptors, Virus; D003404:Creatinine