title: Macrophage migration inhibitory factor in fetoplacental tissues from preeclamptic pregnancies with or without fetal growth restriction.
abstract: The proinflammatory cytokine MIF (macrophage migration inhibitory factor) is involved in physiological and pathological processes in pregnancy. MIF maternal serum levels are increased in preeclampsia (PE). We hypothesize that pregnancy tissues are the source of MIF overexpression in PE. MIF protein was studied in maternal sera, placental tissues, fetal membranes, and umbilical cord of 8 control and 20 PE pregnancies: 10 with normal fetal growth (PE-AGA) and 10 with fetal growth restriction (PE-FGR). MIF levels were significantly higher in PE-AGA membranes than in controls and PE-FGR. In PE-FGR, MIF cord concentrations were higher than in PE-AGA while MIF placental levels were lower than in controls. MIF maternal serum levels were higher in PE, compared to controls, and the difference was mainly due to PE-FGR samples. These data support MIF involvement in PE pathogenesis and suggest that different pregnancy tissues contribute to MIF production in PE with and without fetoplacental compromise.
authors: Department of Obstetrics and Gynecology, University of Turin, Sant'Anna Hospital, Via Ventimiglia 3, 10126 Torino, Italy. simona.cardaropoli@unito.it
authors: Simona
authors: S
authors: Cardaropoli
authors: Luana
authors: L
authors: Paulesu
authors: Roberta
authors: R
authors: Romagnoli
authors: Francesca
authors: F
authors: Ietta
authors: Daniela
authors: D
authors: Marzioni
authors: Mario
authors: M
authors: Castellucci
authors: Alessandro
authors: A
authors: Rolfo
authors: Elena
authors: E
authors: Vasario
authors: Ettore
authors: E
authors: Piccoli
authors: Tullia
authors: T
authors: Todros
mesh_terms: D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005321:Extraembryonic Membranes / Q000378:metabolism*; D005260:Female; D005317:Fetal Growth Retardation; D005786:Gene Expression Regulation; D006801:Humans; D007150:Immunohistochemistry; D019746:Intramolecular Oxidoreductases / Q000235:genetics / Q000378:metabolism*; D008263:Macrophage Migration-Inhibitory Factors / Q000235:genetics / Q000378:metabolism*; D009928:Organ Specificity; D010920:Placenta / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000175:diagnosis* / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D011247:Pregnancy; D014470:Umbilical Cord / Q000378:metabolism
chemical_list: D008263:Macrophage Migration-Inhibitory Factors; D019746:Intramolecular Oxidoreductases; C515598:MIF protein, human