title: Assessment of rodents as animal models for Reston ebolavirus.
abstract: The emergence of Reston ebolavirus (REBOV) in domestic swine in the Philippines has caused a renewed interest in REBOV pathogenicity. Here, the use of different rodent species as animal disease models for REBOV was investigated. BALB/c and STAT1(-)(/-) mice, Hartley guinea pigs, and Syrian hamsters were inoculated intraperitoneally with REBOV strain Pennsylvania or Reston08-A. Although virus replication occurred in guinea pigs, hamsters, and STAT1(-/-) mice, progression to disease was only observed in STAT1(-)(/-) mice. Moreover, REBOV Pennsylvania was more pathogenic than REBOV Reston08-A in this model. Thus, STAT1(-)(/-) mice may be used for research of REBOV pathogenicity and intervention strategies.
authors: Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
authors: Emmie
authors: E
authors: de Wit
authors: Vincent J
authors: VJ
authors: Munster
authors: Samia A
authors: SA
authors: Metwally
authors: Heinz
authors: H
authors: Feldmann
mesh_terms: D000818:Animals; D006224:Cricetinae; D004195:Disease Models, Animal; D029043:Ebolavirus / Q000472:pathogenicity*; D005260:Female; D006168:Guinea Pigs; D019142:Hemorrhagic Fever, Ebola / Q000821:virology*; D008099:Liver / Q000821:virology; D008168:Lung / Q000821:virology; D008647:Mesocricetus; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D050794:STAT1 Transcription Factor / Q000235:genetics / Q000378:metabolism; D013154:Spleen / Q000821:virology; D013997:Time Factors; D014766:Viremia; D014774:Virulence
chemical_list: D050794:STAT1 Transcription Factor; C494080:Stat1 protein, mouse