title: Viral determinants of FeLV infection and pathogenesis: lessons learned from analysis of a natural cohort.
abstract: Detailed analysis has been performed over many years of a geographic and temporal cohort of cats naturally infected with feline leukemia virus (FeLV). Molecular analysis of FeLV present in the diseased tissues and application of those viruses to experimental systems has revealed unique isolates with distinctive disease potential, previously uncharacterized virus-receptor interactions, information about the role of recombinant viruses in disease induction, and novel viral and cellular oncogenes implicated in pathogenesis, among other findings. The studies have contributed to an understanding of the selective forces that lead to predominance of distinctive FeLV isolates and disease outcomes in a natural population.
authors: Department of Microbiology and Immunology, School of Medicine, Tulane University, 1430 Tulane Avenue SL-38, New Orleans, LA 70112, USA. lbolin@tulane.edu
authors: Lisa L
authors: LL
authors: Bolin
authors: Laura S
authors: LS
authors: Levy
mesh_terms: D000818:Animals; D002415:Cats; D015331:Cohort Studies; D014644:Genetic Variation; D054884:Host-Pathogen Interactions; D006801:Humans; D005256:Leukemia Virus, Feline / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D016582:Leukemia, Feline / Q000821:virology*; D012641:Selection, Genetic; D014412:Tumor Virus Infections / Q000662:veterinary* / Q000821:virology; D014759:Viral Envelope Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D014759:Viral Envelope Proteins