title: Genetic variants, immune function, and risk of pre-eclampsia among American Indians.
abstract: OBJECTIVE
  To determine the prevalence in an American Indian population of genetic variants with putative effects on immune function and determine if they are associated with pre-eclampsia (PE).
  
  
  METHODS
  In a study of 66 cases and 130 matched controls, six single nucleotide polymorphisms (SNP) with either previously demonstrated or postulated modulating effects on the immune system were genotyped. Allele frequencies and various genetic models were evaluated by conditional logistic regression in both univariate and multiply adjusted models.
  
  
  RESULTS
  Although most genetic variants lacked evidence of association with PE, the minor allele of the CRP related, rs1205 SNP in a dominant model with adjustment for age at delivery, nulliparity, and body mass index, exhibited an odds ratio of 0.259 (95% CI of 0.08-0.81, P=0.020) in relation to severe PE (48 cases). The allelic prevalence of this variant was 46.1% in this population.
  
  
  CONCLUSIONS
  Of the six SNPs related to immune function in this study, a functional variant in the 3'UTR of the CRP gene was shown to be associated with severe PE in an American Indian population.
authors: Department of Natural Sciences, Turtle Mountain Community College, Belcourt, ND 58366, USA. sbest@utma.com
authors: Lyle G
authors: LG
authors: Best
authors: Melanie
authors: M
authors: Nadeau
authors: Kylie
authors: K
authors: Davis
authors: Felicia
authors: F
authors: Lamb
authors: Shellee
authors: S
authors: Bercier
authors: Cindy M
authors: CM
authors: Anderson
mesh_terms: D002097:C-Reactive Protein / Q000235:genetics* / Q000276:immunology; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000453:epidemiology / Q000235:genetics / Q000276:immunology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000235:genetics; D055815:Young Adult
chemical_list: D002097:C-Reactive Protein