title: The sFlt-1/PlGF ratio in different types of hypertensive pregnancy disorders and its prognostic potential in preeclamptic patients.
abstract: OBJECTIVE
  The soluble fms-like tyrosine kinase (sFlt-1)/placental growth factor (PlGF) ratio is a reliable tool in the assessment of preeclampsia. We tested the hypothesis that the sFlt-1/PlGF ratio is able to identify women at risk for imminent delivery. We characterized the sFlt-1/PlGF ratio in different types of hypertensive pregnancy disorders.
  
  
  METHODS
  We investigated 388 singleton pregnancies with normal pregnancy outcome, 164 with PE, 36 with gestational hypertension, and 42 with chronic hypertension. sFlt-1 and PlGF were measured in serum samples.
  
  
  RESULTS
  Patients with preeclampsia had a significantly increased sFlt-1/PlGF ratio as compared with controls and with patients with chronic and gestational hypertension in <34 weeks and ≥34 weeks (P < .001). Time to delivery was significantly reduced in women with preeclampsia in the highest quartile of the sFlt-1/PlGF ratio (P < .001).
  
  
  CONCLUSIONS
  The sFlt-1/PlGF ratio allows the identification of women at risk for imminent delivery and is a reliable tool to discriminate between different types of pregnancy-related hypertensive disorders.
authors: Department of Obstetrics, Campus Virchow-Clinic, Charité University Medicine, Berlin, Germany. stefan.verlohren@charite.de
authors: Stefan
authors: S
authors: Verlohren
authors: Ignacio
authors: I
authors: Herraiz
authors: Olav
authors: O
authors: Lapaire
authors: Dietmar
authors: D
authors: Schlembach
authors: Manfred
authors: M
authors: Moertl
authors: Harald
authors: H
authors: Zeisler
authors: Pavel
authors: P
authors: Calda
authors: Wolfgang
authors: W
authors: Holzgreve
authors: Alberto
authors: A
authors: Galindo
authors: Theresa
authors: T
authors: Engels
authors: Barbara
authors: B
authors: Denk
authors: Holger
authors: H
authors: Stepan
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008565:Membrane Proteins / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011379:Prognosis; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood*
chemical_list: D015415:Biomarkers; D008565:Membrane Proteins; C098069:PIGF protein, human; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1