title: Ten years experience of directly observed treatment short-course (dots) therapy for tuberculosis in Addis Ababa, Ethiopia.
abstract: BACKGROUND
  Tuberculosis (TB) is still the leading cause of death worldwide accounting for 2.5% of the global burden of disease and 25% of all avoidable deaths in developing countries.
  
  
  OBJECTIVE
  The aim of the study was to evaluate the impact of the Directly Observed Treatment-Short course (DOTS) programme in Addis Ababa, Ethiopia from 1998-2007.
  
  
  METHODS
  Institutional-based retrospective study was employed Reports using world health organization (WHO) format for TB case finding and treatment outcome from all Sub-cities of the city to the Federal Ministry of Health were collected
  
  
  RESULTS
  Between the years (1998-2007), 133,340 patients with all form of TB were registered. Of these, 40,929 (31%) were AFB + ve Pulmonary TB (PTB+ve), 48,491 (36%) were AFB-ve Pulmonary TB (PTB-ve), and 43,920 (33%) were Extra Pulmonary TB (EPTB) cases. The trend of case detection rate (CDR) for new smear positive pulmonary TB cases has increased from 73% in 1998 to its peak 113% in 2000 and then it decreased to 68% in 2007. The treatment success rate (TSR) has value with an average and standard deviation of 80% and 3.2, respectively from 1999 to 2007.
  
  
  CONCLUSIONS
  It is possible to achieve the recommended WHO target (70% CDR & 85% TSR) as can be seen how closely these targets were approached (68% & 81%, respectively) in the city in 2007; However, this requires seeking alternative case finding mechanisms.
authors: College of Medicine and Health Sciences, Department of Microbiology, Immunology and Parasitology. P.O.Box 196, Gondar, Ethiopia. desalegn01@gmail.com
authors: Desalegn
authors: D
authors: Woldeyohannes
authors: Nigatu
authors: N
authors: Kebede
authors: Woldaregay
authors: W
authors: Erku
authors: Zerihun
authors: Z
authors: Tadesse
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000995:Antitubercular Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D023801:Directly Observed Therapy; D005002:Ethiopia / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D012189:Retrospective Studies; D017678:Sex Distribution; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents