title: High prevalence of coexisting prehypertension and prediabetes among healthy adults in northern and northeastern China.
abstract: BACKGROUND
  Prehypertension and prediabetes are major risk factors of cardiovascular disease, and their combined presence may result in more serious cardiovascular outcomes than expected with either prehypertension or prediabetes alone. The aim of the present study was to evaluate the prevalence of coexisting prehypertension and prediabetes, and the associated risk profiles in a Chinese population.
  
  
  METHODS
  A cross-sectional survey in a representative sample of 3,595 men and 4,593 women aged 18 years and older was performed between 2008 and 2010. Prehypertension and prediabetes were diagnosed using the guidelines from the Seventh Report of the Joint National Committee on prevention, detection, and treatment of high blood pressure and American Diabetes Association, respectively. Prehypertension was defined as a systolic blood pressure of 120-139 mmHg and/or diastolic blood pressure of 80-89 mmHg, and prediabetes was defined as a fasting blood glucose of 5.6-6.9 mmol/L.
  
  
  RESULTS
  The prevalence of coexisting prehypertension and prediabetes was 11.0%. Men had a higher prevalence of coexisting prehypertension and prediabetes than women (14.2% vs. 8.4%; P < 0.0001). This prevalence increased with age and body mass index, and was the lowest among Mongolian-Chinese (5.1%). A multivariate analysis showed that γ-glutamyltransferase and uric acid were significantly and positively correlated with body mass index, waist circumference, blood pressure, triglycerides, and total cholesterol, and negatively correlated with high density lipoprotein cholesterol in subjects with prehypertension and prediabetes.
  
  
  CONCLUSIONS
  There is a large proportion of Chinese adults with coexisting prehypertension and prediabetes. Thus, there is a need for more efforts that implement public health programs that target the earlier stages of hypertension and diabetes.
authors: Jie
authors: J
authors: Wu
authors: Wen-hua
authors: WH
authors: Yan
authors: Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Bejing 100730, China.
authors: Ling
authors: L
authors: Qiu
authors: Xin-qi
authors: XQ
authors: Chen
authors: Xiu-zhi
authors: XZ
authors: Guo
authors: Wei
authors: W
authors: Wu
authors: Liang-yu
authors: LY
authors: Xia
authors: Xu-zhen
authors: XZ
authors: Qin
authors: Yan-hong
authors: YH
authors: Liu
authors: Hai-tao
authors: HT
authors: Ding
authors: Shao-mei
authors: SM
authors: Han
authors: Cheng-li
authors: CL
authors: Xu
authors: Guang-jin
authors: GJ
authors: Zhu
mesh_terms: D000293:Adolescent; D000328:Adult; D000886:Anthropometry; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000502:physiology; D002318:Cardiovascular Diseases / Q000453:epidemiology; D002681:China / Q000453:epidemiology; D002784:Cholesterol / Q000097:blood; D016000:Cluster Analysis; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000097:blood / Q000453:epidemiology*; D058246:Prehypertension / Q000097:blood / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors; D012424:Rural Population / Q000706:statistics & numerical data; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D014505:Urban Population / Q000706:statistics & numerical data; D014527:Uric Acid / Q000097:blood; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D014527:Uric Acid; D002784:Cholesterol