title: A double-blind randomized controlled comparison of APDDR-0901, a novel cosmeceutical formulation, and 0.1% adapalene gel in the treatment of mild-to-moderate acne vulgaris.
abstract: Topical retinoids have been widely used in the treatment of acne. They comprise several products used as prescription drugs as well as cosmeceuticals. Of these products, retinol has better tolerability compared with prescription retinoids such as tretinoin, but it is only used in cosmeceuticals due to its low biologic activity. A combination formulation could be an effective alternative to address the problem of decreased therapeutic activity. Recently, hexamidine diisethionate is known to have antibacterial activity, and rose extract has been shown to possess anti-inflammatory activity. In this study, we compared the efficacy and safety of the combination product APDDR-0901 (0.03% retinol, 0.7% rose extract, and 0.05% hexamidine diisethionate) vs 0.1% adapalene gel for the treatment of mild-to-moderate acne. This 12-week, multicenter, double-blinded study included 97 patients with mild-to-moderate acne. Efficacy was evaluated using 4 discrete variables: lesion count, acne grade, physician-assessed global improvement, and patient self-assessment. We also assessed safety profiles, including cutaneous irritation. Both APDDR-0901 and adapalene showed significant improvements without significant differences. Otherwise, the APDDR-0901 group showed better safety profiles, particularly in the first 2 weeks. In conclusion, APDDR-0901 could be an effective and safe alternative in the treatment of mild-to-moderate acne.
authors: Department of Dermatology, Hanyang University College of Medicine, Seoul 133-792, South Korea.
authors: Ha Eun
authors: HE
authors: Lee
authors: Joo Yeon
authors: JY
authors: Ko
authors: Young Hoon
authors: YH
authors: Kim
authors: Seo Rye
authors: SR
authors: Yoo
authors: Sang Ho
authors: SH
authors: Moon
authors: Nack In
authors: NI
authors: Kim
authors: Chun Wook
authors: CW
authors: Park
authors: Jeong Hwan
authors: JH
authors: Kim
authors: Hyun Ju
authors: HJ
authors: Koh
authors: Won Seok
authors: WS
authors: Park
authors: Young Suck
authors: YS
authors: Ro
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000068816:Adapalene; D000293:Adolescent; D000328:Adult; D001550:Benzamidines / Q000008:administration & dosage*; D003358:Cosmetics / Q000008:administration & dosage; D003879:Dermatologic Agents / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D009281:Naphthalenes / Q000008:administration & dosage*; D010936:Plant Extracts / Q000008:administration & dosage*; D016896:Treatment Outcome; D014801:Vitamin A / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: C571279:APDDR-0901; D001550:Benzamidines; D003358:Cosmetics; D003879:Dermatologic Agents; D005782:Gels; D009281:Naphthalenes; D010936:Plant Extracts; D014801:Vitamin A; D000068816:Adapalene; C018961:hexamidine