title: Genes differentially expressed in the peripheral zone compared to the transitional zone of the normal human prostate and their potential regulation by ETS factors.
abstract: Prostate cancer (PCa) is a clinically heterogeneous and multifocal disease             with a clinical outcome that is difficult to predict. Notably, predisposition             to develop prostate cancer is different among the prostate zones, with the peripheral             zone (PZ) or prostate proper as the most frequent site compared to the transitional             zone (TZ). Translocations between the TMPRSS2 gene and a number of members of             the ETS family are frequently found in PCa. Here, we examined expression differences             among the two zones by laser microdissection of normal tissues from PCa patients             to separate glands from stroma, and investigated the gene expression differences             in the glands of the PZ compared to those of the TZ using microarray analysis.             We identified 9 genes involved in the so-called metastatic cascade, to be highly             differentially expressed in the normal glands of the PZ compared to those of the             TZ. The genes which were found to be up-regulated in the PZ compared to the TZ             are commonly up-regulated in tumors. These findings may explain the lower susceptibility             for PCa of the TZ compared to the PZ. According to bioinformatic analysis, 8/9             of these genes may be potentially regulated by ETS transcription factors.
authors: Institute of Pathology, University Hospital Bonn, D-53127 Bonn,                     Germany.
authors: David
authors: D
authors: Adler
authors: Andreas
authors: A
authors: Lindstrot
authors: Jörg
authors: J
authors: Ellinger
authors: Sebastian
authors: S
authors: Rogenhofer
authors: Reinhard
authors: R
authors: Buettner
authors: Nicolas
authors: N
authors: Wernert
mesh_terms: D001665:Binding Sites; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D011401:Promoter Regions, Genetic; D011471:Prostatic Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D050783:Proto-Oncogene Proteins c-ets / Q000235:genetics* / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D050783:Proto-Oncogene Proteins c-ets