title: Biotin biosynthesis in Mycobacterium tuberculosis: physiology, biochemistry and molecular intervention.
abstract: Biotin is an important micronutrient that serves as an essential enzyme cofactor. Bacteria obtain biotin either through de novo synthesis or by active uptake from exogenous sources. Mycobacteria are unusual amongst bacteria in that their primary source of biotin is through de novo synthesis. Here we review the importance of biotin biosynthesis in the lifecycle of Mycobacteria. Genetic screens designed to identify key metabolic processes have highlighted a role for the biotin biosynthesis in bacilli growth, infection and survival during the latency phase. These studies help to establish the biotin biosynthetic pathway as a potential drug target for new anti-tuberculosis agents.
authors: School of Molecular and Biomedical Sciences, University of Adelaide, South Australia 5005, Australia.
authors: Wanisa
authors: W
authors: Salaemae
authors: Al
authors: A
authors: Azhar
authors: Grant W
authors: GW
authors: Booker
authors: Steven W
authors: SW
authors: Polyak
mesh_terms: D001710:Biotin / Q000096:biosynthesis*; D019735:Carbon-Carbon Ligases / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D003067:Coenzymes / Q000378:metabolism; D005227:Fatty Acids / Q000096:biosynthesis; D005798:Genes, Bacterial; D016680:Genome, Bacterial; D053858:Metabolic Networks and Pathways; D015394:Molecular Structure; D009164:Mycobacterium Infections / Q000382:microbiology; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity / Q000502:physiology*; D014774:Virulence
chemical_list: D002352:Carrier Proteins; D003067:Coenzymes; D005227:Fatty Acids; D001710:Biotin; D019735:Carbon-Carbon Ligases; C018757:acyl-CoA carboxylase