title: Effects of beta-carotene supplements on cancer prevention: meta-analysis of randomized controlled trials.
abstract: This meta-analysis aimed to investigate the effects of beta-carotene supplements alone on cancer prevention as reported by randomized controlled trials (RCTs). We searched PubMed, EMBASE, and CENTRAL. Among the 848 articles searched, 6 randomized controlled trials, including 40,544 total participants, 20,290 in beta-carotene supplement groups, and 20,254 in placebo groups, were included in the final analysis. In a meta-analysis of 6 RCTs, beta-carotene supplements had no preventive effect on either cancer incidence [relative risk (RR) = 1.08, 95% confidence interval (CI) = 0.99-1.18] or cancer mortality (RR = 1.00, 95% CI = 0.87-1.15). Similar findings were observed in both primary prevention trials and secondary prevention trials. Subgroup analyses by various factors revealed no preventive effect of beta-carotene supplementation on cancer prevention and that it significantly increased the risk of urothelial cancer, especially bladder cancer (RR = 1.52, 95% CI = 1.03-2.24) and marginally increased the risk of cancer among current smokers (RR = 1.07, 95% CI = 0.99-1.17). The current meta-analysis of RCTs indicated that there is no clinical evidence to support the overall primary or secondary preventive effect of beta-carotene supplements on cancer. The potential effects, either beneficial or harmful, of beta-carotene supplementation on cancer should not be overemphasized.
authors: Department of Family Medicine, Inje University Haeundae Paik Hospital, Busan, Republic of Korea.
authors: Young-Jee
authors: YJ
authors: Jeon
authors: Seung-Kwon
authors: SK
authors: Myung
authors: Eun-Hyun
authors: EH
authors: Lee
authors: Yeol
authors: Y
authors: Kim
authors: Yoon Jung
authors: YJ
authors: Chang
authors: Woong
authors: W
authors: Ju
authors: Hong-Jun
authors: HJ
authors: Cho
authors: Hong Gwan
authors: HG
authors: Seo
authors: Bong Yul
authors: BY
authors: Huh
mesh_terms: D016588:Anticarcinogenic Agents / Q000008:administration & dosage; D000975:Antioxidants / Q000008:administration & dosage; D016208:Databases, Factual; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015994:Incidence; D009369:Neoplasms / Q000453:epidemiology* / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D012907:Smoking / Q000378:metabolism; D019207:beta Carotene / Q000008:administration & dosage*
chemical_list: D016588:Anticarcinogenic Agents; D000975:Antioxidants; D019207:beta Carotene