title: Mortality of cerebral venous-sinus thrombosis in a large national sample.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the mortality rates associated with cerebral venous-sinus thrombosis in a large national sample.
  
  
  METHODS
  A cohort of patients with cerebral venous-sinus thrombosis was identified from the National Inpatient Sample database for the years 2000 to 2007. According to the International Classification of Diseases, 9th Revision, Clinical Modification codes, cerebral venous-sinus thrombosis is categorized into pyogenic and nonpyogenic groups. Multivariate logistic regression analysis was used to assess covariates associated with hospital mortality.
  
  
  RESULTS
  Among 3488 patients, the overall mortality rate was 4.39%, which was nonsignificantly higher among the pyogenic group (4.55% versus 3.52%; OR, 0.76; 95% CI, 0.47-1.23). In the pyogenic cerebral venous-sinus thrombosis group, hematologic disorders were the most frequent predisposing condition (16.2%); whereas systemic malignancy followed by hematologic disorders were most common in the nonpyogenic group (14.08% and 10.04%, respectively). Predictors of mortality included age, intracerebral hemorrhage as well as the predisposing conditions of hematologic disorders, systemic malignancy, and central nervous system infection.
  
  
  CONCLUSIONS
  Compared with arterial stroke, CVST harbors a relatively low mortality rate. Death is determined by age, the presence of intracerebral hemorrhage, and certain predisposing conditions.
authors: Souers Stroke Institute, Department of Neurology, St Louis University, 1438 S Grand Boulevard, St Louis, MO 63104, USA.
authors: Afshin
authors: A
authors: Borhani Haghighi
authors: Randall C
authors: RC
authors: Edgell
authors: Salvador
authors: S
authors: Cruz-Flores
authors: Eli
authors: E
authors: Feen
authors: Paisith
authors: P
authors: Piriyawat
authors: Nirav
authors: N
authors: Vora
authors: R Charles
authors: RC
authors: Callison
authors: Amer
authors: A
authors: Alshekhlee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D016208:Databases, Factual; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012851:Sinus Thrombosis, Intracranial / Q000401:mortality*; D015996:Survival Rate; D014481:United States / Q000453:epidemiology