title: The formulation of polyhedral boranes for the boron neutron capture therapy of cancer.
abstract: The early promise of boron neutron capture therapy as a method for the treatment of cancer has been inhibited by the inherent toxicity associated with therapeutically useful doses of ¹⁰B-containing pharmacophores, the need for target-tissue specificity and the challenges imposed by biological barriers. Although developments in the synthetic chemistry of polyhedral boranes have addressed issues of toxicity to a considerable extent, the optimisation of the transport and the delivery of boronated agents to the site of action--the subject of this review--is a challenge that is addressed by the development of innovative formulation strategies.
authors: School of Pharmacy and Chemistry, Kingston University, Kingston-upon Thames KT1 2EE, UK. G.Calabrese@kingston.ac.uk
authors: Gianpiero
authors: G
authors: Calabrese
authors: John J
authors: JJ
authors: Nesnas
authors: Eugen
authors: E
authors: Barbu
authors: Dimitris
authors: D
authors: Fatouros
authors: John
authors: J
authors: Tsibouklis
mesh_terms: D000818:Animals; D001692:Biological Transport; D001880:Boranes / Q000737:chemistry* / Q000493:pharmacokinetics; D001896:Boron Compounds / Q000009:adverse effects / Q000737:chemistry / Q000493:pharmacokinetics; D016754:Boron Neutron Capture Therapy / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy*
chemical_list: D001880:Boranes; D001896:Boron Compounds