title: Diversity and phylogenetic relationships among the North American Tacaribe serocomplex viruses (family Arenaviridae).
abstract: The purpose of this study was to extend our knowledge of the genetic diversity and phylogenetic relationships among the North American Tacaribe serocomplex viruses. Analyses of glycoprotein precursor gene sequence data separated the North American arenaviruses into 7 major phylogenetic groups. The results of analyses of Z gene and nucleocapsid protein gene sequence data were not remarkably different from the glycoprotein precursor gene tree. In contrast, the tree generated from RNA-dependent RNA polymerase gene sequences differed from the glycoprotein precursor gene tree with regard to phylogenetic relationships among the viruses associated with woodrats captured in the western United States, Texas, or northern Mexico. Further analyses of the polymerase gene sequence data set suggested that the difference in topology was a consequence of incongruence among the gene tree data sets or chance rather than genetic reassortment or recombination between arenaviruses.
authors: Department of Pathology, The University of Texas Medical Branch, Galveston, TX 77555-0609, USA. nbcajirm@utmb.edu
authors: Maria N B
authors: MN
authors: Cajimat
authors: Mary Louise
authors: ML
authors: Milazzo
authors: Michelle L
authors: ML
authors: Haynie
authors: J Delton
authors: JD
authors: Hanson
authors: Robert D
authors: RD
authors: Bradley
authors: Charles F
authors: CF
authors: Fulhorst
mesh_terms: D000818:Animals; D001117:Arenaviridae Infections / Q000821:virology; D006477:Arenaviruses, New World / Q000145:classification* / Q000235:genetics*; D001483:Base Sequence; D004268:DNA-Binding Proteins / Q000235:genetics*; D019143:Evolution, Molecular; D005814:Genes, Viral; D014644:Genetic Variation; D006023:Glycoproteins / Q000235:genetics; D009656:North America; D019590:Nucleocapsid Proteins / Q000235:genetics*; D010802:Phylogeny; D012324:RNA-Dependent RNA Polymerase / Q000235:genetics; D051381:Rats; D016415:Sequence Alignment; D017423:Sequence Analysis, RNA; D014764:Viral Proteins / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D006023:Glycoproteins; D019590:Nucleocapsid Proteins; D014764:Viral Proteins; C079186:Z protein, Tacaribe virus; D012324:RNA-Dependent RNA Polymerase