title: Cerebral blood flow changes in very-late-onset schizophrenia-like psychosis with catatonia before and after successful treatment.
abstract: The purpose of the present study was to investigate regional cerebral blood flow (rCBF) changes in a patient with very-late-onset schizophrenia-like psychosis (VLOS) with catatonia. A 64-year-old woman developed catatonia after experiencing persecutory delusions. The patient's rCBF was examined using single photon emission computed tomography (SPECT) with easy Z-score imaging system. Before treatment, hypoperfusion was observed in the striatum and the thalamus, whereas hyperperfusion was observed in the left lateral frontal cortex and the left temporal cortex. After treatment, the disproportions in rCBF disappeared, and hyperperfusion was observed in the motor cortex. Sequential SPECT findings suggest that rCBF abnormalities may be correlated with the symptomatology of catatonia in patients with VLOS.
authors: Department of Neuropsychiatry, Toho University School of Medicine, Ota-ku, Tokyo, Japan. ntsujino@med.toho-u.ac.jp
authors: Naohisa
authors: N
authors: Tsujino
authors: Takahiro
authors: T
authors: Nemoto
authors: Taiju
authors: T
authors: Yamaguchi
authors: Naoyuki
authors: N
authors: Katagiri
authors: Nao
authors: N
authors: Tohgi
authors: Ryu
authors: R
authors: Ikeda
authors: Nobuyuki
authors: N
authors: Shiraga
authors: Sunao
authors: S
authors: Mizumura
authors: Masafumi
authors: M
authors: Mizuno
mesh_terms: D014150:Antipsychotic Agents / Q000494:pharmacology / Q000627:therapeutic use; D000068180:Aripiprazole; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001931:Brain Mapping; D002389:Catatonia / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006220:Haloperidol / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D010879:Piperazines / Q000494:pharmacology / Q000627:therapeutic use; D011618:Psychotic Disorders / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology*; D015363:Quinolones / Q000494:pharmacology / Q000627:therapeutic use; D012559:Schizophrenia / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology*; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D010879:Piperazines; D015363:Quinolones; D000068180:Aripiprazole; D006220:Haloperidol