title: Description of a prospective 17DD yellow fever vaccine cohort in Recife, Brazil.
abstract: From September 2005 to March 2007, 238 individuals being vaccinated for the first time with the yellow fever (YF) -17DD vaccine were enrolled in a cohort established in Recife, Brazil. A prospective study indicated that, after immunization, anti-YF immunoglobulin M (IgM) and anti-YF IgG were present in 70.6% (IgM) and 98.3% (IgG) of the vaccinated subjects. All vaccinees developed protective immunity, which was detected by the plaque reduction neutralization test (PRNT) with a geometric mean titer of 892. Of the 238 individuals, 86.6% had IgG antibodies to dengue virus; however, the presence of anti-dengue IgG did not interfere significantly with the development of anti-YF neutralizing antibodies. In a separate retrospective study of individuals immunized with the 17DD vaccine, the PRNT values at 5 and 10 years post-vaccination remained positive but showed a significant decrease in neutralization titer (25% with PRNT titers < 100 after 5 years and 35% after 10 years).
authors: Virology and Experimental Therapy Laboratory, Aggeu Magalhães Research Center, Fiocruz, Recife, Pernambuco, Brazil. abm@cpqam.fiocruz.br
authors: Andréa Barbosa
authors: AB
authors: de Melo
authors: Maria da Paz C
authors: Mda P
authors: da Silva
authors: Maria Cecília F
authors: MC
authors: Magalhães
authors: Laura Helena Vega
authors: LH
authors: Gonzales Gil
authors: Eduardo M
authors: EM
authors: Freese de Carvalho
authors: Ulisses M
authors: UM
authors: Braga-Neto
authors: Giovani Rota
authors: GR
authors: Bertani
authors: Ernesto T A
authors: ET
authors: Marques
authors: Marli Tenório
authors: MT
authors: Cordeiro
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D001938:Brazil; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D009500:Neutralization Tests; D011446:Prospective Studies; D010948:Viral Plaque Assay; D022341:Yellow Fever Vaccine / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D022341:Yellow Fever Vaccine