title: Synchronous bilateral urothelial cancer in a kidney recipient.
abstract: Synchronous bilateral urothelial cancer is very rare. We report a 25-year-old male kidney recipient with Alport syndrome who developed bilateral synchronous urothelial cancer after transplantation. At the age of 16 this patient was referred to our clinic for a kidney transplantation. A living related donor kidney transplantation was performed with cyclosporin-based quadruple immunosuppression. He experienced no acute rejection and his graft function was excellent after transplantation. Nine years after transplantation, he complained of asymptomatic gross hematuria and was diagnosed as having a bilateral urothelial cancer in the native upper urinary tracts. A bilateral total nephroureterectomy was undertaken, and the postoperative pathological diagnosis was advanced bilateral urothelial carcinoma. The patient received adjuvant gemcitabine plus cisplatin chemotherapy at a cisplatin dosage reduced by 50%. After 4 years of follow-up, he is alive with a functioning graft and no evidence of recurrence.
authors: Department of Urology, Division of Nephrology and Hypertension, St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan. ryuto@marianna-u.ac.jp
authors: Ryuto
authors: R
authors: Nakazawa
authors: Satetsu
authors: S
authors: Miyano
authors: Hideo
authors: H
authors: Sasaki
authors: Hiroya
authors: H
authors: Kudo
authors: Kenjiro
authors: K
authors: Kimura
authors: Tatsuya
authors: T
authors: Chikaraishi
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002277:Carcinoma / Q000188:drug therapy / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000188:drug therapy / Q000601:surgery*; D014516:Ureteral Neoplasms / Q000188:drug therapy / Q000601:surgery*; D019459:Urothelium / Q000473:pathology; D000093542:Gemcitabine
chemical_list: D003841:Deoxycytidine; D002945:Cisplatin; D000093542:Gemcitabine