title: A threat of the Klebsiella pneumoniae carbapenemase-producing strains among transplant recipients.
abstract: BACKGROUND
  Infections due to Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae are associated with increased therapeutic failure and mortality. Our laboratory recognized several strains producing KPC, most of which originated from transplantation ward patients.
  
  
  METHODS
  All strains of K pneumoniae resistant to at least 1 carbapenem isolated in 2010 were examined for KPC production by disc diffusion and then verified by molecular methods.
  
  
  RESULTS
  All positive strains originated from 7 patients. Six of them were from transplantation wards. None of the KPC-producing strains was isolated from the patient's blood.
  
  
  CONCLUSIONS
  A quick, accurate diagnosis of KPC-producing strains enabled immediate isolation of carriers or infected persons. Isolation prevented spread of dangerous strains among immunocompromised patients and reduced the possibility of serious infections.
authors: Department of Medical Microbiology, Medical University of Warsaw, Warsaw, Poland.
authors: G
authors: G
authors: Mlynarczyk
authors: E
authors: E
authors: Kosykowska
authors: S Walter
authors: SW
authors: de Walthoffen
authors: K
authors: K
authors: Szymanek-Majchrzak
authors: A
authors: A
authors: Sawicka-Grzelak
authors: T
authors: T
authors: Baczkowska
authors: J
authors: J
authors: Pazik
authors: M
authors: M
authors: Durlik
authors: M
authors: M
authors: Ciszek
authors: L
authors: L
authors: Paczek
authors: A
authors: A
authors: Chmura
authors: A
authors: A
authors: Mlynarczyk
mesh_terms: D001426:Bacterial Proteins / Q000096:biosynthesis*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D007710:Klebsiella Infections / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology* / Q000302:isolation & purification; D016031:Liver Transplantation / Q000009:adverse effects*; D008826:Microbial Sensitivity Tests; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D001426:Bacterial Proteins; D001618:beta-Lactamases; C063912:carbapenemase