title: What tubulin drugs tell us about microtubule structure and dynamics.
abstract: A wide range of small molecules, including alkaloids, macrolides and peptides, bind to tubulin and disturb microtubule assembly dynamics. Some agents inhibit assembly, others inhibit disassembly. The binding sites of drugs that stabilize microtubules are discussed in relation to the properties of microtubule associated proteins. The activities of assembly inhibitors are discussed in relation to different nucleotide states of tubulin family protein structures.
authors: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK. laa@mrc-lmb.cam.ac.uk
authors: Linda A
authors: LA
authors: Amos
mesh_terms: D001665:Binding Sites; D006801:Humans; D008870:Microtubules / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure*; D014404:Tubulin / Q000737:chemistry* / Q000378:metabolism* / Q000648:ultrastructure; D050257:Tubulin Modulators / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D014404:Tubulin; D050257:Tubulin Modulators