title: Identifying a new locus that regulates the development of rete ovarian cysts in MRL/MpJ mice.
abstract: MRL/MpJ (MRL) is a mouse model for autoimmune disease and develops ovarian cysts with age. The ovarian cysts originate from the rete ovarii, which is considered to be the remnant of fetal mesonephric tubules. In a previous study, we analyzed the genetic background of ovarian cysts by using backcross progenies between MRL and C57BL/6N (B6) mice. By interval mapping, suggestive linkages were detected on several chromosomes (Chrs), and a significant linkage on Chr 14 was designated as MRL Rete Ovarian Cyst (mroc). In the present study, which evaluated 113 F2 intercross progenies, a significant linkage appeared on Chr 6 at the marker position D6Mit188 (likelihood ratio statistic = 18.5). In particular, the peak regions of Chrs 6 and 14, which contain major causative loci by backcross analysis, showed close reverse interaction. From these results, a locus on Chr 6 was identified as mroc2, the second major locus associated with ovarian cyst formation in MRL mice.
authors: Laboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.
authors: Shin-Hyo
authors: SH
authors: Lee
authors: Osamu
authors: O
authors: Ichii
authors: Saori
authors: S
authors: Otsuka
authors: Yoshiharu
authors: Y
authors: Hashimoto
authors: Yuka
authors: Y
authors: Namiki
authors: Yasuhiro
authors: Y
authors: Kon
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D016678:Genome; D051379:Mice; D008815:Mice, Inbred Strains; D010048:Ovarian Cysts / Q000235:genetics / Q000378:metabolism*; D040641:Quantitative Trait Loci
chemical_list: D005819:Genetic Markers