title: Restriction of rift valley Fever virus virulence in mosquito cells.
abstract: Arboviruses are maintained in a natural cycle that requires blood-sucking arthropod and vertebrate hosts. Arboviruses are believed to persistently infect their arthropod host without overt pathology and cause acute infection with viremia in their vertebrate host. We have focused on elucidating how a specific arbovirus, Rift Valley fever (RVF) virus, causes cytopathic effect in cells derived from vertebrates and non-cytopathic infection in cells derived from arthropods. We demonstrate that the vertebrate virulence factor, NSs, is functional in arthropod cells but is expressed at significantly lower levels in infected arthropod versus infected vertebrate cells.
authors: Medical Scientist Training Program, School of Medicine, University of Michigan, Ann Arbor, Michigan, USA.
authors: Valerie M
authors: VM
authors: Vaughn
authors: Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
authors: Cale C
authors: CC
authors: Streeter
authors: Department of Microbiology and Immunology, School of Medicine, University of Michigan, Ann Arbor, Michigan, USA.|Internal Medicine School of Medicine, University of Michigan, Ann Arbor, Michigan, USA.
authors: David J
authors: DJ
authors: Miller
authors: Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
authors: Sonja R
authors: SR
authors: Gerrard