title: Developments towards regioselective synthesis of 1,2-disubstituted benzimidazoles.
abstract: 1,2-Disubstituted benzimidazoles play an important role in several areas and particularly as drug discovery targets. Herein, several methods to assemble these structures are reviewed, from the classical approaches to the more recently developed metal-catalyzed intramolecular amination process, the cascade arylamination/condensation reaction and polymer-supported benzimidazole assembly under microwave conditions.
authors: Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Campus de Caparica, Caparica, Portugal.
authors: Luísa C R
authors: LC
authors: Carvalho
authors: Eduarda
authors: E
authors: Fernandes
authors: M Manuel B
authors: MM
authors: Marques
mesh_terms: D000586:Amination; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002384:Catalysis; D055808:Drug Discovery; D008872:Microwaves; D015394:Molecular Structure
chemical_list: D001562:Benzimidazoles