title: Mortality and morbidity in preterm small-for-gestational-age infants: a population-based study.
abstract: OBJECTIVE
  We sought to evaluate the impact of severity of growth restriction on mortality and major neonatal morbidity among very-low-birthweight small-for-gestational-age infants.
  
  
  METHODS
  This was a population-based observational study using data collected by the Israel National Very-Low-Birth-Weight Infant Database 1995 through 2007 including infants 24-31 weeks' gestation, with birthweight (BW) ≤ 50th percentile without major malformations. Four BW percentile groups were considered: < 3rd, 3rd-< 10th, 10th-< 25th, and a reference group 25th-50th percentile. Univariate and multivariable logistic regression analyses were performed.
  
  
  RESULTS
  Infants of BW 3rd-< 10th percentile were at increased risk for grades 3-4 retinopathy of prematurity (odds ratio [OR], 2.07; 95% confidence interval [CI], 1.54-2.78), bronchopulmonary dysplasia (OR, 2.52; 95% CI, 2.03-3.12), necrotizing enterocolitis (OR, 1.32; 95% CI, 1.04-1.68), and mortality (OR, 2.37; 95% CI, 1.94-2.90). The risk was further increased among infants of BW < 3rd percentile.
  
  
  CONCLUSIONS
  Growth restriction severity may serve as a clinical marker of degree of risk for neonatal mortality and various morbidities.
authors: Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, The Hebrew University Medical School of Jerusalem, Jerusalem, Israel. granovs@012.net.il
authors: Sorina
authors: S
authors: Grisaru-Granovsky
authors: Brian
authors: B
authors: Reichman
authors: Liat
authors: L
authors: Lerner-Geva
authors: Valentina
authors: V
authors: Boyko
authors: Cathy
authors: C
authors: Hammerman
authors: Arnon
authors: A
authors: Samueloff
authors: Michael S
authors: MS
authors: Schimmel
mesh_terms: D016208:Databases, Factual; D005260:Female; D006801:Humans; D015994:Incidence; D007226:Infant Mortality; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000453:epidemiology* / Q000401:mortality; D007236:Infant, Small for Gestational Age; D008297:Male; D011247:Pregnancy; D012720:Severity of Illness Index