title: Ameliorative effect of BDNF on prenatal ethanol and stress exposure-induced behavioral disorders.
abstract: Brain-derived neurotrophic factor (BDNF) plays critical role in neuronal development, function, survival and plasticity of mature neurons. The present experiments investigated whether BDNF ameliorates the damaging effect of prenatal ethanol and stress exposure on behavior in offspring. Prenatal exposure of ethanol and stress combined during gestation inverted sexual partner preference of male offspring, increased social contacts with juvenile male mouse and stereotypic burying activity in the marble-burying test suggesting predisposition to homosexuality and to obsessive-compulsive disorder. Centrally administered BDNF (300ng i.c.v.) restored sexual female preference of male adult offspring and decreased marble-burying activity. Ameliorative effect was shown in 7-10 days after BDNF administration. The results provide the first evidence that BDNF improves epigenetic impairment of behavior and may have profound implications in the treatment of neurologic disorders induced by early environmental challenges.
authors: Department of Behavioral Neurogenomics, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Lavrentyeva av. 10, 630090 Novosibirsk, Russia. npopova@bionet.nsc.ru
authors: Nina K
authors: NK
authors: Popova
authors: Maryana V
authors: MV
authors: Morozova
authors: Vladimir S
authors: VS
authors: Naumenko
mesh_terms: D020268:Alcohol-Induced Disorders, Nervous System / Q000188:drug therapy* / Q000378:metabolism*; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000502:physiology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D001523:Mental Disorders / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D051379:Mice; D008808:Mice, Inbred CBA; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000188:drug therapy* / Q000378:metabolism*; D012726:Sexual Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D013315:Stress, Psychological / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D019208:Brain-Derived Neurotrophic Factor