title: The role of TRPA1 in visceral inflammation and pain.
abstract: Despite significant progress in our understanding of the cellular and molecular mechanisms underlying sensory transduction and nociception, clinical pain management remains a considerable challenge in health care and basic research. The identification of the superfamily of transient receptor potential (TRP) cation channels, particularly TRPV1 and TRPA1, has shed light on the molecular basis of pain signaling during inflammatory conditions. TRPV1 and TRPA1 are considered as potential targets in the treatment of inflammatory pain because of their ability to be activated by nociceptive signals and sensitized by pro-inflammatory mediators. Notably, TRPA1 is expressed in visceral afferent neurons and is known to participate in inflammatory responses and the establishment of hypersensitivity. This review summarizes the current knowledge of the role of TRPA1 in sensory transduction, particularly in the context of visceral inflammation and pain in the gastrointestinal and urinary tracts.
authors: University of Calgary, AB, Canada.
authors: Tamia K
authors: TK
authors: Lapointe
authors: Christophe
authors: C
authors: Altier
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000378:metabolism*; D041981:Gastrointestinal Tract / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D018836:Inflammation Mediators / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D059225:Nociception; D000074025:TRPA1 Cation Channel; D050916:TRPV Cation Channels / Q000378:metabolism; D050051:Transient Receptor Potential Channels / Q000378:metabolism*; D014551:Urinary Tract / Q000378:metabolism* / Q000503:physiopathology; D059265:Visceral Pain / Q000378:metabolism*
chemical_list: D015220:Calcium Channels; D018836:Inflammation Mediators; D009419:Nerve Tissue Proteins; D000074025:TRPA1 Cation Channel; C473350:TRPA1 protein, human; D050916:TRPV Cation Channels; C494482:TRPV1 protein, human; D050051:Transient Receptor Potential Channels