title: Mast cell interleukin-2 production contributes to suppression of chronic allergic dermatitis.
abstract: The incidence of chronic allergic dermatitis is rapidly increasing. Regulatory control of this disease has not been adequately explored. Here we report that mast cell-derived interleukin-2 (IL-2) contributes to the suppression of chronic allergic dermatitis. Mice deficient in IL-2 production, or deficient in mast cells (Kit(W-sh/W-sh)), showed exacerbated dermatitis upon repeated oxazolone challenge when compared to their wild-type counterparts. Adoptive transfer of wild-type, but not Il2(-/-), mast cells into Kit(W-sh/W-sh) mice dampened the inflammatory response. During the course of disease, mast cell expansion occurred at the site of inflammation and also in the spleen, where production of IL-2 by mast cells was markedly enhanced. In the absence of mast cell IL-2 production, the ratio of activated to regulatory T cells at the site of inflammation was increased. Thus, MC-derived IL-2 contributes to the maintenance of suppression in chronic allergic skin inflammation.
authors: Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
authors: Alon Y
authors: AY
authors: Hershko
authors: Ryo
authors: R
authors: Suzuki
authors: Nicolas
authors: N
authors: Charles
authors: Damiana
authors: D
authors: Alvarez-Errico
authors: Jennifer L
authors: JL
authors: Sargent
authors: Arian
authors: A
authors: Laurence
authors: Juan
authors: J
authors: Rivera
mesh_terms: D000818:Animals; D002908:Chronic Disease; D003876:Dermatitis, Atopic / Q000139:chemically induced / Q000276:immunology* / Q000473:pathology; D007073:Immunoglobulin E / Q000276:immunology; D007376:Interleukin-2 / Q000096:biosynthesis* / Q000172:deficiency / Q000276:immunology; D008407:Mast Cells / Q000276:immunology*; D051379:Mice; D018345:Mice, Knockout; D010081:Oxazolone; D013154:Spleen / Q000276:immunology
chemical_list: D007376:Interleukin-2; D010081:Oxazolone; D007073:Immunoglobulin E