title: Expression of the tumor suppressor miR-206 is associated with cellular proliferative inhibition and impairs invasion in ERα-positive endometrioid adenocarcinoma.
abstract: This study investigated the role of miR-206 in estrogen receptor-α (ERα)-positive endometrial endometrioid adenocarcinoma (EEC). We profiled miR-206 expression in 30 EEC clinical samples using qRT-PCR, and explored its relationship with ERα and clinical parameters. A luciferase reporter assay assessed the ERα targeting potential of miR-206. Functional analyses of miR-206 were performed in EEC cell lines. MiRNA-206 expression decreased in ERα-positive EECs, and its expression was negatively correlated with ERα. MiRNA-206 overexpression inhibited ERα-dependent proliferation, impaired invasiveness and induced cell cycle arrest of ERα-positive EEC cell lines. Therefore, aberrantly expressed miRNA-206 may be associated with the development of ERα-positive EEC.
authors: International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University School of Medicine, No. 910 Hengshan Road, Shanghai, China.
authors: Xiaoyue
authors: X
authors: Chen
authors: Qin
authors: Q
authors: Yan
authors: Shuangdi
authors: S
authors: Li
authors: Long
authors: L
authors: Zhou
authors: Huajing
authors: H
authors: Yang
authors: Yixia
authors: Y
authors: Yang
authors: Xuelian
authors: X
authors: Liu
authors: Xiaoping
authors: X
authors: Wan
mesh_terms: D000328:Adult; D018269:Carcinoma, Endometrioid / Q000737:chemistry / Q000473:pathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D016889:Endometrial Neoplasms / Q000737:chemistry / Q000473:pathology*; D047628:Estrogen Receptor alpha / Q000032:analysis* / Q000235:genetics / Q000502:physiology; D005260:Female; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D008875:Middle Aged; D009361:Neoplasm Invasiveness
chemical_list: C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; C546087:MIRN206 microRNA, human; D035683:MicroRNAs