title: Two-year experience of obstetric cholestasis: outcome and management.
abstract: OBJECTIVE
  Our aim was to evaluate the management and outcome of obstetric cholestasis in our perinatology unit.
  
  
  METHODS
  We analyzed 44 pregnant women complicated by cholestasis. Data were collected retrospectively. Details of patient demographics and outcomes of pregnancy were recorded. Patients were randomized due to their decision to take ursodeoxycholic acid (UDCA) therapy or not.
  
  
  RESULTS
  Forty-four women of age 28.09 +/- 4.6 years delivered 45 newborns. The mean gestational age at diagnosis of obstetric cholestasis was 32.36 +/- 3.75 weeks. The mean delivery time was 38.25 +/- 1.5 weeks. Spontaneous premature delivery occurred in five (11.4%) of the patients. No stillbirths were observed. Serum transaminases decreased significantly in 26 of the patients who were treated with oral UDCA therapy. Twelve (27.2%) babies were admitted to the neonatal intensive care unit (NICU). Out of 12 mothers whose babies were admitted to NICU, nine patients had not received UDCA (p = 0.07).
  
  
  CONCLUSIONS
  UDCA is effective in lowering transaminases.
authors: Dr. Zekai Tahir Burak Women Health Research and Education Hospital, Ankara, Turkey. deveer3@hotmail.com
authors: R
authors: R
authors: Deveer
authors: Y
authors: Y
authors: Engin-Ustun
authors: S
authors: S
authors: Celen
authors: O G
authors: OG
authors: Eryilmaz
authors: E
authors: E
authors: Tonguç
authors: L
authors: L
authors: Mollamahmutoğlu
authors: A
authors: A
authors: Oksuzoglu
authors: N
authors: N
authors: Danisman
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D002756:Cholagogues and Choleretics / Q000627:therapeutic use*; D002779:Cholestasis / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D010343:Patient Admission / Q000706:statistics & numerical data; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D011256:Pregnancy Outcome; D012127:Respiratory Distress Syndrome, Newborn / Q000453:epidemiology; D012189:Retrospective Studies; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use*
chemical_list: D002756:Cholagogues and Choleretics; D014580:Ursodeoxycholic Acid; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase