title: Reconstruction of 3-D histology images by simultaneous deformable registration.
abstract: The reconstruction of histology sections into a 3-D volume receives increased attention due to its various applications in modern medical image analysis. To guarantee a geometrically coherent reconstruction, we propose a new way to register histological sections simuItaneously to previously acquired reference images and to neighboring slices in the stack. To this end, we formulate two potential functions and associate them to the same Markov random field through which we can efficiently find an optimal solution. Due to our simultaneous formulation and the absence of any segmentation step during the reconstruction we can dramatically reduce error propagation effects. This is illustrated by experiments on carefully created synthetic as well as real data sets.
authors: microDimensions and Computer Aided Medical Procedures (CAMP Technische Universität München, Germany.
authors: Marco
authors: M
authors: Feuerstein
authors: Hauke
authors: H
authors: Heibel
authors: José
authors: J
authors: Gardiazabal
authors: Nassir
authors: N
authors: Navab
authors: Martin
authors: M
authors: Groher
mesh_terms: D000465:Algorithms; D000818:Animals; D001331:Automation; D003952:Diagnostic Imaging / Q000379:methods; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007668:Kidney / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008390:Markov Chains; D015233:Models, Statistical; D051381:Rats