title: Synthesis and structure-activity relationship studies of dihydronaphthyridinediones as a novel structural class of potent and selective PDE7 inhibitors.
abstract: The synthesis and SAR studies of a series of structurally novel inhibitors of PDE7 are discussed. The best compounds from the series display low nanomolar inhibitory activity and are selective versus other PDE isoenzymes.
authors: biocrea GmbH, Meissner Strasse 191, 01445 Radebeul, Germany. rainer.gewald@biocrea.com
authors: Rainer
authors: R
authors: Gewald
authors: Carla
authors: C
authors: Rueger
authors: Christian
authors: C
authors: Grunwald
authors: Ute
authors: U
authors: Egerland
authors: Norbert
authors: N
authors: Hoefgen
mesh_terms: D000818:Animals; D054708:Cyclic Nucleotide Phosphodiesterases, Type 7 / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008958:Models, Molecular; D009287:Naphthyridines / Q000737:chemistry* / Q000494:pharmacology*; D011485:Protein Binding; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D009287:Naphthyridines; D054708:Cyclic Nucleotide Phosphodiesterases, Type 7; C517458:PDE7A protein, human