title: Aberrant DNA methylation of drug metabolism and transport genes in nodular goiter.
abstract: The genes encoding drug-metabolizing enzymes and transporters play an important role in maintaining the normal life processes of human body. Their disorder or defect will lead to the occurrence and development of various diseases. Currently, most of studies have focused on genetic variations in these genes, however, in the present study, we analyzed promoter methylation of 11 drug metabolism and transport genes in a cohort of nodular goiter and normal thyroid tissues using methylation-specific PCR (MSP). Our data first revealed a distinct methylation profiling in drug metabolism and transport genes between nodular goiter and normal thyroid tissues, particularly ABCB4, CYP1B1 and CYP24A1 and SLC1A2. Given these genes contribute to the development and progression of various diseases, such as multidrug resistance and tumorigenesis, these epigenetic events may thus play a critical role in the pathogenesis of nodular goiter.
authors: Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an 710061, the People's Republic of China. jimeiju@yahoo.com.
authors: Lihong
authors: L
authors: Zhang
authors: Jing
authors: J
authors: Shi
authors: Li
authors: L
authors: Xu
authors: Bingyin
authors: B
authors: Shi
authors: Peng
authors: P
authors: Hou
authors: Meiju
authors: M
authors: Ji