title: Circulating vitamin D and colorectal adenoma in asymptomatic average-risk individuals who underwent first screening colonoscopy: a case-control study.
abstract: BACKGROUND
  A higher circulating vitamin D level is inversely associated with the risk of colorectal cancer, but the association with adenoma risk is less clear.
  
  
  OBJECTIVE
  We examined the association between the circulating 25-hydroxyvitamin D(3) [25(OH)D(3)] concentration and colorectal adenoma in asymptomatic average-risk participants undergoing initial screening colonoscopy.
  
  
  METHODS
  The study subjects were comprised of 143 cases of colorectal adenomas and 143 age- and gender-matched controls with normal colonoscopy among the 586 asymptomatic average-risk subjects (median age, 58 years; range, 50-73 years) who underwent first screening colonoscopy and measurement of the serum 25(OH)D(3) between December 2009 and April 2010, consistent with winter months of the region.
  
  
  RESULTS
  The mean concentration of serum 25(OH)D(3) in the adenoma and control groups was 20.0 ± 11.0 ng/ml and 25.0 ± 20.0 ng/ml, respectively (P = 0.009). Using multivariate analysis, higher levels of 25(OH)D(3) were associated with a statistically significant decreased risk of colorectal adenoma after multivariable adjustment (highest vs. lowest quartile OR 0.38, 95% CI 0.18-0.80, P (trend) = 0.012). The inverse association of circulating 25(OH)D(3) with colorectal adenoma was stronger among the patients with proximal adenoma than that among the patients without proximal adenoma (highest vs. lowest quartile OR 0.29, 95% CI 0.13-0.66, P (trend) = 0.001).
  
  
  CONCLUSIONS
  The present study suggests that high levels of circulating vitamin D are associated with a decreased risk of colorectal adenoma, and especially adenoma located in the proximal colon.
authors: Department of Internal Medicine, Konkuk University School of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, Seoul 143-729, Korea.
authors: Sung Noh
authors: SN
authors: Hong
authors: Jeong Hwan
authors: JH
authors: Kim
authors: Won Hyeok
authors: WH
authors: Choe
authors: Sun-Young
authors: SY
authors: Lee
authors: Dong Choon
authors: DC
authors: Seol
authors: Hee-Won
authors: HW
authors: Moon
authors: Mina
authors: M
authors: Hur
authors: Yeo-Min
authors: YM
authors: Yun
authors: In Kyung
authors: IK
authors: Sung
authors: Hyung Seok
authors: HS
authors: Park
authors: Chan Sup
authors: CS
authors: Shim
mesh_terms: D000236:Adenoma / Q000097:blood / Q000453:epidemiology / Q000473:pathology; D017677:Age Distribution; D000368:Aged; D002112:Calcifediol / Q000097:blood*; D016022:Case-Control Studies; D003106:Colon / Q000473:pathology; D003113:Colonoscopy / Q000706:statistics & numerical data*; D015179:Colorectal Neoplasms / Q000097:blood / Q000453:epidemiology / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000706:statistics & numerical data*; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors
chemical_list: D002112:Calcifediol