title: Dietary vitamin E deficiency increases anxiety-like behavior in juvenile and adult rats.
abstract: Vitamin E deficiency from birth or infancy has recently been found to increase anxiety-like behavior in rodents. The present study was undertaken to elucidate the effect of dietary vitamin E deficiency on anxiety in adult rats in comparison with juvenile rats. Male Wistar rats, 3 or 10 weeks old, were divided into two groups and fed a control or vitamin E-deficient diet for 4 weeks. The results of behavioral analysis revealed that vitamin E-deficiency increased anxiety in both juvenile and adult rats. Plasma, liver, and brain α-tocopherol concentrations decreased significantly due to vitamin E deficiency in both age groups. Plasma corticosterone concentrations were higher in the vitamin E-deficient rats in response to the stress of a behavioral test. Based on these results, we conclude that dietary vitamin-E deficiency induces anxiety in adult rats as well as juvenile rats. This might be due to an elevated plasma corticosterone concentration.
authors: Department of Agricultural Chemistry, Faculty of Agriculture, Meiji University, Kawasaki, Kanagawa, Japan.
authors: Yuki
authors: Y
authors: Terada
authors: Yuki
authors: Y
authors: Okura
authors: Takefumi
authors: T
authors: Kikusui
authors: Asako
authors: A
authors: Takenaka
mesh_terms: D000375:Aging; D000818:Animals; D001007:Anxiety / Q000097:blood / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D001522:Behavior, Animal; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D003345:Corticosterone / Q000097:blood; D004032:Diet; D008099:Liver / Q000378:metabolism; D008297:Male; D018782:Maze Learning; D009132:Muscles / Q000378:metabolism; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014811:Vitamin E Deficiency / Q000150:complications*; D024502:alpha-Tocopherol / Q000097:blood / Q000378:metabolism
chemical_list: D015415:Biomarkers; D017392:Thiobarbituric Acid Reactive Substances; D024502:alpha-Tocopherol; D003345:Corticosterone