title: [Macrolides in antibiotic therapy of infections of the bronchial tree].
abstract: Macrolide antibiotics have been used to treat acute and chronic inflammation in the respiratory tract based on their antibacterial activity. Now it is well known that macrolides down-regulate damaging prolonged inflammation as well as increase mucous clearance and decrease bacterial virulence. Their ability to inhibit bacterial biofilm is a very important point in control of infections of the bronchial tree, where colonization of Haemophilus influenzae, Streptococcus pneumoniae and Pseudomonas aeruginosa were documented in clinical and experimental studies.
authors: Military Institute of Health Services, Department of Internal Medicine, Pneumonology and Allergology, Warsaw, Poland.
authors: Tadeusz
authors: T
authors: Płusa
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D001419:Bacteria / Q000472:pathogenicity; D001424:Bacterial Infections / Q000188:drug therapy*; D018441:Biofilms / Q000187:drug effects; D001980:Bronchi / Q000382:microbiology; D001991:Bronchitis / Q000188:drug therapy*; D015536:Down-Regulation; D006801:Humans; D018942:Macrolides / Q000627:therapeutic use*; D009079:Mucociliary Clearance / Q000187:drug effects*; D014774:Virulence / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D018942:Macrolides