title: Allosteric regulation of phenylalanine hydroxylase.
abstract: The liver enzyme phenylalanine hydroxylase is responsible for conversion of excess phenylalanine in the diet to tyrosine. Phenylalanine hydroxylase is activated by phenylalanine; this activation is inhibited by the physiological reducing substrate tetrahydrobiopterin. Phosphorylation of Ser16 lowers the concentration of phenylalanine for activation. This review discusses the present understanding of the molecular details of the allosteric regulation of the enzyme.
authors: Department of Biochemistry and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, TX 78229-3900, USA. fitzpatrick@biochem.uthscsa.edu
authors: Paul F
authors: PF
authors: Fitzpatrick
mesh_terms: D000494:Allosteric Regulation; D000818:Animals; D006801:Humans; D010651:Phenylalanine Hydroxylase / Q000737:chemistry* / Q000378:metabolism*; D010766:Phosphorylation
chemical_list: D010651:Phenylalanine Hydroxylase