title: Reduced sebum production in Turner syndrome: a study of twenty-two patients.
abstract: Turner's syndrome (TS) is a genetic disorder caused by numeric and/or structural abnormalities of the X chromosome. In a previous study it was observed that acne is less frequent in TS than in the general population. Since the onset of acne in pre-pubertal or pubertal age is related to sebum production, this study evaluates sebum secretion in TS patients, comparing the results with those of a control group of age-matched healthy female subjects. A total of 22 patients affected by TS (mean age 26.56±7.89 years) and a control group of 23 age-matched healthy females were studied. Sebum production was measured using a Sebumeter SM810. Mean sebum secretion in TS subjects was significantly lower than in the control group (81.35±66.44 UA vs 147.09±33.62 UA, p<0.001) and this significant difference was found in every facial zone. The reduction of sebum secretion may explain, using a simple and non-invasive method, the absence or the low incidence of acne in TS patients.
authors: Valeria
authors: V
authors: Brazzelli
authors: V
authors: V
authors: Calcaterra
authors: F
authors: F
authors: Muzio
authors: C
authors: C
authors: Klersy
authors: D
authors: D
authors: Larizza
authors: G
authors: G
authors: Borroni
mesh_terms: D000152:Acne Vulgaris / Q000453:epidemiology; D000293:Adolescent; D000328:Adult; D001940:Breast / Q000254:growth & development; D002648:Child; D005145:Face; D005260:Female; D013006:Growth Hormone / Q000627:therapeutic use; D006801:Humans; D007621:Karyotyping; D011627:Puberty / Q000502:physiology; D012629:Sebum / Q000378:metabolism*; D014424:Turner Syndrome / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism*; D055815:Young Adult
chemical_list: D013006:Growth Hormone