title: Could dietary trans fatty acids induce movement disorders? Effects of exercise and its influence on Na⁺K⁺-ATPase and catalase activity in rat striatum.
abstract: The influence of trans fatty acids (FA) on development of orofacial dyskinesia (OD) and locomotor activity was evaluated. Rats were fed with diets enriched with 20% soybean oil (SO; n-6 FA), lard (L; saturated FA) or hydrogenated vegetable fat (HVF; trans FA) for 60 weeks. In the last 12 weeks each group was subdivided into sedentary and exercised (swimming). Brains of HVF and L-fed rats incorporated 0.33% and 0.20% of trans FA, respectively, while SO-fed group showed no incorporation of trans FA. HVF increased OD, while exercise exacerbated this in L and HVF-fed rats. HVF and L reduced locomotor activity, and exercise did not modify. Striatal catalase activity was reduced by L and HVF, but exercise increased its activity in the HVF-fed group. Na(+)K(+)-ATPase activity was not modified by dietary FA, however it was increased by exercise in striatum of SO and L-fed rats. We hypothesized that movement disorders elicited by HVF and less by L could be related to increased dopamine levels in striatum, which have been related to chronic trans FA intake. Exercise increased OD possibly by increase of brain dopamine levels, which generates pro-oxidant metabolites. Thus, a long-term intake of trans FA caused a small but significant brain incorporation of trans FA, which favored development of movement disorders. Exercise worsened behavioral outcomes of HVF and L-fed rats and increased Na(+)K(+)-ATPase activity of L and SO-fed rats, indicating its benefits. HVF blunted beneficial effects of exercise, indicating a critical role of trans FA in brain neurochemistry.
authors: Programa de Pós-Graduação em Farmacologia-Universidade Federal de Santa Maria-RS, Brazil.
authors: A M
authors: AM
authors: Teixeira
authors: V T
authors: VT
authors: Dias
authors: C S
authors: CS
authors: Pase
authors: K
authors: K
authors: Roversi
authors: N
authors: N
authors: Boufleur
authors: R C S
authors: RC
authors: Barcelos
authors: D M
authors: DM
authors: Benvegnú
authors: F
authors: F
authors: Trevizol
authors: G S
authors: GS
authors: Dolci
authors: N R
authors: NR
authors: Carvalho
authors: A
authors: A
authors: Quatrin
authors: F A A
authors: FA
authors: Soares
authors: P
authors: P
authors: Reckziegel
authors: H J
authors: HJ
authors: Segat
authors: J B T
authors: JB
authors: Rocha
authors: T
authors: T
authors: Emanuelli
authors: M E
authors: ME
authors: Bürger
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism*; D003342:Corpus Striatum / Q000201:enzymology*; D004041:Dietary Fats / Q000009:adverse effects*; D004409:Dyskinesia, Drug-Induced / Q000378:metabolism*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010805:Physical Conditioning, Animal / Q000379:methods / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D044242:Trans Fatty Acids / Q000009:adverse effects* / Q000378:metabolism
chemical_list: D004041:Dietary Fats; D044242:Trans Fatty Acids; D002374:Catalase; D000254:Sodium-Potassium-Exchanging ATPase