title: Usabamycins A-C: new anthramycin-type analogues from a marine-derived actinomycete.
abstract: New anthramycin-type analogues, designated usabamycin A-C (1, 2 and 3), have been isolated from cultures of Streptomyces sp. NPS853, a bacterium found in marine sediments. The structures of the new compounds were established on the basis of extensive spectroscopic analyses including 1D- and 2D-NMR ((1)H-(1)H COSY, HSQC, and HMBC) experiments. The usabamycins show weak inhibition of HeLa cell growth and selective inhibition of serotonin (5-hydroxytrypamine) 5-HT(2B) uptake.
authors: Central Research Laboratory, Tokyo Innovation Center, Nippon Suisan Kaisha, Ltd, Hachioji, Tokyo, Japan. s-satou@nissui.co.jp
authors: Seizo
authors: S
authors: Sato
authors: Fumie
authors: F
authors: Iwata
authors: Shoichi
authors: S
authors: Yamada
authors: Hiroyuki
authors: H
authors: Kawahara
authors: Masashi
authors: M
authors: Katayama
mesh_terms: D039903:Actinobacteria / Q000737:chemistry*; D000876:Anthramycin / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012702:Serotonin Antagonists / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D012702:Serotonin Antagonists; C571320:usabamycin A; C571322:usabamycin B; C571321:usabamycin C; D000876:Anthramycin