title: Prognostic clinicopathologic factors in longitudinally followed patients with metastatic small bowel carcinoid tumors.
abstract: OBJECTIVE
  Neuroendocrine tumors demonstrate heterogeneous behavior based on the site of origin and histology. This study aimed to delineate prognostic clinicopathologic features in patients with metastatic midgut carcinoid.
  
  
  METHODS
  All patients underwent resection of the primary tumor in the setting of metastatic disease. Survival was measured from the date of primary tumor resection and calculated by Kaplan-Meier estimation. Clinical data include age, sex, serum biomarkers, primary tumor size, Ki-67 index, and the performance of hepatic cytoreductive procedure. Serially collected serum biomarkers were considered as mean values within periods relative to primary resection: preoperative, 0 to 1 year postoperative, and years 1 to 5 postoperative. Log-rank comparisons were used to assess the prognostic value of the aforementioned features.
  
  
  RESULTS
  Forty-nine patients (21 men) with metastatic midgut carcinoid who underwent primary tumor resection were identified. Median survival was 121 months. The overall 5-year survival rate was 83%. Age higher than 65 years (P = 0.01) and late postoperative chromogranin A (CgA; P = 0.02) were associated with decreased survival.
  
  
  CONCLUSIONS
  This study highlights the favorable prognosis of patients with metastatic small bowel carcinoid in a multidisciplinary treatment program. Among other factors, elevated postoperative CgA is associated with decreased survival. The significance of increased CgA over time underlies the importance of longitudinal follow-up for these patients.
authors: Division of Gastroenterology, Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA.
authors: Thomas
authors: T
authors: Curran
authors: Sheryl
authors: S
authors: Tulin-Silver
authors: Kalpesh
authors: K
authors: Patel
authors: Stephen
authors: S
authors: Ward
authors: Melissa
authors: M
authors: Schneiderman
authors: Noam
authors: N
authors: Harpaz
authors: Myron
authors: M
authors: Schwartz
authors: Steven
authors: S
authors: Itzkowitz
authors: Richard R P
authors: RR
authors: Warner
authors: Michelle Kang
authors: MK
authors: Kim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis / Q000097:blood; D002276:Carcinoid Tumor / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D053379:Chromogranin A / Q000032:analysis / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D005770:Gastrointestinal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D053208:Kaplan-Meier Estimate; D019394:Ki-67 Antigen / Q000032:analysis; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D053379:Chromogranin A; D019394:Ki-67 Antigen