title: Multidrug-resistant tuberculosis, People's Republic of China, 2007-2009.
abstract: We conducted a case-control study to investigate risk factors for multidrug-resistant tuberculosis (MDR TB) in the People's Republic of China. Genotyping analysis was used to estimate the percentage of cases from recent transmission among 100 MDR TB case-patients hospitalized during April 2007-July 2009. Molecular subtyping of isolates showed that 41% of MDR TB strains clustered. Beijing genotype was found in 94% of the MDR TB isolates and 79% of the pan-susceptible isolates. In multivariate analysis, MDR TB was independently associated with Beijing genotype, retreatment for TB, symptoms lasting >3 months before first evaluation at the hospital, lack of health insurance, and being a farmer (vs. being a student). MDR TB was associated with Beijing genotype and lower socioeconomic status. A large percentage of MDR TB cases seemed to result from recent transmission. Early detection, effective treatment, and infection control measures for MDR TB are needed to reduce transmission.
authors: Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China. heguangxue@chinatb.org
authors: Guang Xue
authors: GX
authors: He
authors: Hai Ying
authors: HY
authors: Wang
authors: Martien W
authors: MW
authors: Borgdorff
authors: Dick
authors: D
authors: van Soolingen
authors: Marieke J
authors: MJ
authors: van der Werf
authors: Zhi Min
authors: ZM
authors: Liu
authors: Xue Zheng
authors: XZ
authors: Li
authors: Hui
authors: H
authors: Guo
authors: Yan Lin
authors: YL
authors: Zhao
authors: Jay K
authors: JK
authors: Varma
authors: Christopher P
authors: CP
authors: Tostado
authors: Susan
authors: S
authors: van den Hof
mesh_terms: D000328:Adult; D000904:Antibiotics, Antitubercular / Q000494:pharmacology; D015373:Bacterial Typing Techniques; D016022:Case-Control Studies; D002681:China; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000187:drug effects / Q000235:genetics*; D010802:Phylogeny; D012307:Risk Factors; D018088:Tuberculosis, Multidrug-Resistant / Q000382:microbiology* / Q000635:transmission
chemical_list: D000904:Antibiotics, Antitubercular