title: Phyllodes tumor of the breast: role of CD10 in predicting metastasis.
abstract: BACKGROUND
  Phyllodes tumors are classified as benign, borderline, and malignant according to a group of histological features. The expression of many biological markers has been explored to discriminate between different grades of phyllodes tumor and to predict their behavior. The immunohistochemical expression of CD10 has been shown to discriminate between benign and other grades of phyllodes tumor but has not been evaluated as a predictor of metastasis. The purpose of this study was to evaluate the usefulness of immunohistochemical staining of stromal CD10 in predicting the likelihood of metastasis in phyllodes tumors.
  
  
  METHODS
  The expression of CD10 was studied in 43 phyllodes tumors (16 benign, 10 borderline, and 17 malignant) using immunohistochemistry to evaluate whether differences in expression correlated with the presence of, and or, development of distant metastasis.
  
  
  RESULTS
  Metastasis occurred in six malignant phyllodes tumors. The expression of CD10 significantly (P<0.05) correlated with the occurrence of distant metastasis.
  
  
  CONCLUSIONS
  The expression of CD10 can be used to predict the occurrence of distant metastasis in phyllodes tumors of the breast.
authors: Department of Surgical Oncology, King Hussein Cancer Center, Amman, Jordan. malmasri@khcc.jo
authors: Mahmoud
authors: M
authors: Al-Masri
authors: Ghaleb
authors: G
authors: Darwazeh
authors: Samer
authors: S
authors: Sawalhi
authors: Ayman
authors: A
authors: Mughrabi
authors: Maher
authors: M
authors: Sughayer
authors: Marwa
authors: M
authors: Al-Shatti
mesh_terms: D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D060787:Neoplasm Grading; D015260:Neprilysin / Q000378:metabolism*; D003557:Phyllodes Tumor / Q000378:metabolism* / Q000473:pathology / Q000556:secondary*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D015260:Neprilysin