title: Alcaligenes xylosoxidans contact lens-related keratitis--a case report and literature review.
abstract: BACKGROUND
  Alcaligenes xylosoxidans can result in opportunistic infections in patients who are immunocompromised. Alcaligenes xylosoxidans keratitis is a rare infection, almost always occurring in a compromised cornea. Few reported cases have occurred as contact lens-induced keratitis. The purposes of this report are to report a case of A. xylosoxidans keratitis in an immunocompetent contact lens wearer (2-week disposable) and to review the related literature.
  
  
  METHODS
  A 30-year-old man developed acute keratitis in the right eye. He was a 2-week disposable contact lens wearer. He did not report any ocular or systemic illness. Corneal scraping, contact lens, and conjunctiva cultures were performed.
  
  
  RESULTS
  0.5% moxifloxacin eye drops were started hourly with quick recovery and healing of the ulcer and epithelial defect noted within a few days. Culture of the contact lens was positive for A. xylosoxidans. The organism was sensitive to penicillins, third-generation cephalosporins, and fluoroquinolones but resistant to aminoglycosides.
  
  
  CONCLUSIONS
  Alcaligenes xylosoxidans is a potential pathogen in compromised corneas. It has high susceptibility to extended-spectrum penicillins and current generations of fluoroquinolones but rarely responds to aminoglycosides. Alcaligenes xylosoxidans should be considered in the differential diagnosis of contact lens-induced keratitis.
authors: Makkah Eye Complex, Khartoum, Sudan. Abdu1974@hotmail.com
authors: Abdalla Awadalla
authors: AA
authors: Ahmed
authors: Roberto
authors: R
authors: Pineda
mesh_terms: D000328:Adult; D000421:Alcaligenes / Q000302:isolation & purification*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001372:Aza Compounds / Q000627:therapeutic use; D003228:Conjunctiva / Q000382:microbiology; D003261:Contact Lenses / Q000382:microbiology*; D003315:Cornea / Q000382:microbiology; D024841:Fluoroquinolones; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy; D006801:Humans; D007634:Keratitis / Q000188:drug therapy / Q000382:microbiology*; D008297:Male; D000077266:Moxifloxacin; D011804:Quinolines / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D000077266:Moxifloxacin