title: Hepatoprotective activity of Tribulus terrestris extract against acetaminophen-induced toxicity in a freshwater fish (Oreochromis mossambicus).
abstract: The potential protective role of Tribulus terrestris in acetaminophen-induced hepatotoxicity in Oreochromis mossambicus was investigated. The effect of oral exposure of acetaminophen (500 mg/kg) in O. mossambicus at 24-h duration was evaluated. The plant extract (250 mg/kg) showed a remarkable hepatoprotective activity against acetaminophen-induced hepatotoxicity. It was judged from the tissue-damaging level and antioxidant levels in liver, gill, muscle and kidney tissues. Further acetaminophen impact induced a significant rise in the tissue-damaging level, and the antioxidant level was discernible from the enzyme activity modulations such as glutamate oxaloacetic transaminase, glutamate pyruvic transaminase, alkaline phosphatase, acid phosphatase, glucose-6-phosphate dehydrogenase, lactate dehydrogenase, superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione S-transferase, lipid peroxidase and reduced glutathione. The levels of all these enzymes have significantly (p < 0.05) increased in acetaminophen-treated fish tissues. The elevated levels of these enzymes were significantly controlled by the treatment of T. terrestris extract (250 kg/mg). Histopathological changes of liver, gill and muscle samples were compared with respective controls. The results of the present study specify the hepatoprotective and antioxidant properties of T. terrestris against acetaminophen-induced toxicity in freshwater fish, O. mossambicus.
authors: Department of Animal Science, Bharathidasan University, Tiruchirappalli 620 024, Tamil Nadu, India. kavithabio200481@gmail.com
authors: P
authors: P
authors: Kavitha
authors: R
authors: R
authors: Ramesh
authors: G
authors: G
authors: Bupesh
authors: A
authors: A
authors: Stalin
authors: P
authors: P
authors: Subramanian
mesh_terms: D000082:Acetaminophen / Q000633:toxicity*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D000431:Ethanol; D005419:Flavonoids / Q000032:analysis; D005618:Fresh Water; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D010936:Plant Extracts / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology*; D012015:Reference Standards; D017210:Tilapia / Q000378:metabolism*; D018675:Toxicity Tests; D032444:Tribulus / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D010936:Plant Extracts; D020011:Protective Agents; D000082:Acetaminophen; D000431:Ethanol