title: Restricted access to myeloid cells explained.
abstract: The lentiviral accessory protein, Vpx, is known to counteract a restriction factor that is specific to myeloid cells, such as macrophages and dendritic cells. This review summarizes the findings in two seminal studies that identify SAMHD1 as the cellular protein that is responsible for myeloid cell restriction, and establish the existence of other types of restriction in these cells.
authors: Division of Microbiology and Immunology, Department of Pathology, School of Medicine, University of Utah, Emma Eccles Jones Building, 15 North Medical Drive East 2100, Room 2520, Salt Lake City, UT 84112, USA. vicente.planelles@path.utah.edu
authors: Vicente
authors: V
authors: Planelles
mesh_terms: D000818:Animals; D020274:Autoimmune Diseases of the Nervous System / Q000821:virology; D003713:Dendritic Cells / Q000378:metabolism / Q000821:virology; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000235:genetics / Q000502:physiology*; D015498:HIV-2 / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008264:Macrophages / Q000378:metabolism / Q000821:virology; D020559:Monomeric GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D022423:Myeloid Cells / Q000378:metabolism* / Q000821:virology; D009421:Nervous System Malformations / Q000821:virology; D000076106:SAM Domain and HD Domain-Containing Protein 1; D015302:Simian Immunodeficiency Virus / Q000235:genetics; D054334:Viral Regulatory and Accessory Proteins / Q000378:metabolism; D014779:Virus Replication
chemical_list: C074286:VPX protein, Human immunodeficiency virus 2; D054334:Viral Regulatory and Accessory Proteins; D000076106:SAM Domain and HD Domain-Containing Protein 1; C484280:SAMHD1 protein, human; D020559:Monomeric GTP-Binding Proteins