title: Cutis tricolor parvimaculata in two patients with ring chromosome 15 syndrome.
abstract: Two unrelated girls presented with multiple disseminated, paired, small café-au-lait spots and hypopigmented macules, suggesting didymosis (twin spotting). The girls also had growth retardation, microcephaly, hypertelorism, triangular facies, and a 46,XY, r(15) karyotype. The term cutis tricolor parvimaculata has been proposed to describe a twin spot phenomenon characterized by small, paired hypochromic and hyperchromic macules on a background of normal intermediate-pigmented skin. It has been hypothesized that the underlying gene locus of this phenomenon is a hot spot for postzygotic recombination, resulting in multiple pigmentary twin spots. Future clinical research may show whether analogous "simple" twin-spot phenotypes in the form of cutis tricolor parvimaculata may be considered a further cutaneous sign of the ring chromosome 15 syndrome.
authors: Departments of Dermatology.
authors: María Del Carmen
authors: MDC
authors: Boente
authors: Endocrinology.
authors: Cristina
authors: C
authors: Bazan
authors: Genetics, Hospital del Niño Jesús, Tucumán, Argentina.
authors: Daniela
authors: D
authors: Montanari
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics; D019080:Cafe-au-Lait Spots / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D002675:Child, Preschool; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics; D002658:Developmental Disabilities / Q000235:genetics; D019066:Facies; D005183:Failure to Thrive / Q000235:genetics; D005260:Female; D006801:Humans; D006972:Hypertelorism / Q000235:genetics; D007223:Infant; D008831:Microcephaly / Q000235:genetics; D009030:Mosaicism; D010859:Pigmentation Disorders / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D012303:Ring Chromosomes; D013577:Syndrome