title: A pentad of vancomycin reactions.
abstract: Vancomycin is used in the treatment of infections caused by gram-positive bacteria resistant to beta-lactam antibiotics. It is also used in the treatment ofenterococci, although this use has been limited due to resistance. The authors report the clinical and pathological presentations of 5 different vancomycin hypersensitivity reactions, including morbilliform eruption, erythroderma, acute generalized exanthematous pustulosis, linear immunoglobulin A bullous dermatosis, and toxic epidermal necrolysis. With the increased prevalence of beta-lactam-resistant bacteria, reliance on vancomycin continues to increase; thus, the recognition of reactions to this drug will be helpful in caring for patients who require this medication in the future.
authors: Department of Dermatology, Drexel University College of Medicine, 219 North Broad Street, Philadelphia, PA 19107, USA.
authors: Meghan
authors: M
authors: O'Brien
authors: Avnee
authors: A
authors: Shah
authors: Herbert B
authors: HB
authors: Allen
mesh_terms: D056150:Acute Generalized Exanthematous Pustulosis / Q000139:chemically induced; D000293:Adolescent; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003873:Dermatitis, Exfoliative / Q000139:chemically induced; D003875:Drug Eruptions / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced; D013262:Stevens-Johnson Syndrome / Q000209:etiology; D014640:Vancomycin / Q000009:adverse effects* / Q000627:therapeutic use; D028761:Withholding Treatment
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin