title: [The potential of photodynamic therapy for the treatment of recurrent respiratory papillomatosis].
abstract: The problem of recurrent respiratory papillomatosis (RRP) thus far remains unresolved despite a large number of surgical and conservative methods proposed to address it. Photodynamic therapy is an up-to-date tool for the treatment of various neoplasms based on the interaction between the light and a photosensitizing agent (PA) that gives rise to active oxygen species and causes the death of cells. The potential of photodynamic therapy for the treatment of recurrent respiratory papillomatosis remains to be elucidated. A total of 8 seances of photodynamic therapy were undertaken at the Department of Otorhinolaryngology, I.P. Pavlov Sankt-Peterburg State Medical University, during the period between 2006 and 2010 for the treatment of patients with laryngeal and tracheal lesion, two of them under local anesthesia and the remaining ones under general narcosis. Complete and partial regression of the disease was achieved in 2 and 5 cases respectively. One patient failed to benefit from the treatment. Photodynamic therapy was well tolerated by the patients and produced good functional results; none of them developed adverse effects, there were no signs of refractoriness to the treatment.
authors: Kafedra otorinolaringologii s klinikoĭ Sankt-Peterburgskogo gosudarstvennogo meditsinskogo universiteta im. akad. I.P. Pavlova.
authors: S A
authors: SA
authors: Karpishchenko
authors: M A
authors: MA
authors: Riabova
authors: E B
authors: EB
authors: Katinas
authors: M Iu
authors: MIu
authors: Ulupov
authors: L R
authors: LR
authors: Kucherova
mesh_terms: D006801:Humans; D007822:Laryngeal Neoplasms; D007830:Larynx; D009364:Neoplasm Recurrence, Local; D010036:Otolaryngology; D010212:Papilloma / Q000188:drug therapy; D010778:Photochemotherapy