title: Dendritic cells: novel players in fibrosis and scleroderma.
abstract: Dendritic cells are professional antigen-presenting cells that are most studied for their function in mediating T-cell tolerance and T-cell activation. In addition, recent evidence indicates that dendritic cells can regulate the vasculature and function of fibroblast-type cells. The potential contribution of dendritic cells to scleroderma and fibrosis is not well-understood. In this article, we review recent studies as well as describe our own ongoing work that points toward a role for dendritic cells in scleroderma and fibrosis.
authors: Autoimmunity and Inflammation Program and Pediatric Rheumatology, Hospital for Special Surgery, New York, NY 10021, USA. lut@hss.edu
authors: Theresa T
authors: TT
authors: Lu
mesh_terms: D003713:Dendritic Cells / Q000502:physiology*; D005355:Fibrosis; D006801:Humans; D007668:Kidney / Q000473:pathology*; D008099:Liver / Q000473:pathology*; D008168:Lung / Q000473:pathology*; D012595:Scleroderma, Systemic / Q000503:physiopathology*; D012867:Skin / Q000473:pathology*