title: Synthesis and biological activity of new bispyridinium salts of 4,4'-bispyridyl-5,5'-perfluoroalkyl-2,2'-bisoxazoles.
abstract: A series of bispyridinium compounds were synthesized by a short sequence of reactions from symmetric diamides. All compounds were tested for their antiproliferative activity against HT-29, a cell line derived from a human colon adenocarcinoma, and their inhibitory activity against choline kinase (ChoK), a novel anticancer molecular target already in clinical trials. Most of the compounds analyzed showed good antiproliferative activities, in the micromolar range, with the identification of promising lead molecules as a new family of potential inhibitors of ChoK.
authors: Departamento de Ciencias, Escuela Politécnica, Universidad Europea de Madrid, Villaviciosa de Odón 28670, Madrid, Spain. yolanda.martin@uem.es
authors: Y
authors: Y
authors: Martín-Cantalejo
authors: B
authors: B
authors: Sáez
authors: M I
authors: MI
authors: Monterde
authors: M T
authors: MT
authors: Murillo
authors: M F
authors: MF
authors: Braña
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D002797:Choline Kinase / Q000037:antagonists & inhibitors; D004579:Electron Transport; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D019073:HT29 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D010080:Oxazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011725:Pyridines / Q000737:chemistry*; D012492:Salts / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D010080:Oxazoles; D011725:Pyridines; D012492:Salts; D002797:Choline Kinase; C023666:pyridine