title: Effects of antihypertensive drugs on specific harmonic indices of the pulse waveform in normotensive Wistar Kyoto rats.
abstract: We used a self-comparison method and harmonic analysis to compare the blood pressure wave before and after the injection of antihypertensive drugs (atenolol, captopril, and losartan) in normotensive Wistar Kyoto rats. Systolic and diastolic blood pressures decreased significantly after the intraperitoneal injection of drugs. Atenolol significantly reduced all the harmonic proportions of the pulse wave, while captopril and losartan significantly increased the first and fourth harmonic proportions. These findings are the same as those reported for human subjects and confirm that harmonic analysis of the pressure pulse is a useful method to study the efficacy of antihypertensive drugs.
authors: Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan.
authors: Sheng Hung
authors: SH
authors: Wang
authors: Ming Yie
authors: MY
authors: Jan
authors: Wei Kung
authors: WK
authors: Wang
authors: Yuh Ying Lin
authors: YY
authors: Wang
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001262:Atenolol / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D002216:Captopril / Q000494:pharmacology*; D019808:Losartan / Q000494:pharmacology*; D008297:Male; D023421:Models, Animal; D008955:Models, Cardiovascular; D011673:Pulsatile Flow / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011921:Rats, Inbred WKY
chemical_list: D000959:Antihypertensive Agents; D001262:Atenolol; D002216:Captopril; D019808:Losartan