title: Vanadium bromoperoxidase from Delisea pulchra: enzyme-catalyzed formation of bromofuranone and attendant disruption of quorum sensing.
abstract: Vanadium bromoperoxidase was isolated and cloned from the marine red alga Delisea pulchra. This enzyme catalyzes the bromolactonization of 4-pentynoic acid forming 5E-bromo-methylidenetetrahydro-2-furanone, a compound which is shown herein to inhibit quorum sensing in the engineered reporter strain, Agrobacterium tumefaciens NTL4.
authors: Department of Chemistry & Biochemistry, University of California, Santa Barbara, CA, USA.
authors: Moriah
authors: M
authors: Sandy
authors: Jayme N
authors: JN
authors: Carter-Franklin
authors: Jessica D
authors: JD
authors: Martin
authors: Alison
authors: A
authors: Butler
mesh_terms: D016960:Agrobacterium tumefaciens / Q000187:drug effects / Q000502:physiology; D005663:Furans / Q000737:chemistry / Q000494:pharmacology*; D010544:Peroxidases / Q000737:chemistry* / Q000302:isolation & purification / Q000502:physiology; D053038:Quorum Sensing / Q000187:drug effects*; D000461:Rhodophyta / Q000201:enzymology*; D001616:beta-Galactosidase / Q000378:metabolism
chemical_list: D005663:Furans; D010544:Peroxidases; C026195:bromide peroxidase; D001616:beta-Galactosidase