title: Comparison of a continuous glucose monitoring system with a portable blood glucose meter to determine insulin dose in cats with diabetes mellitus.
abstract: BACKGROUND
  The continuous glucose monitoring system (CGMS) Guardian REAL-Time(®) allows the generation of very detailed glucose profiles in cats. The performance of CGMS to generate short-term glucose profiles to evaluate treatment response has not been yet evaluated in diabetic cats.
  
  
  OBJECTIVE
  Analysis of glucose profiles generated using the CGMS produces insulin dose recommendations that differ from those of profiles generated using the portable blood glucose meter (PBGM) in diabetic cats.
  
  
  METHODS
  Thirteen client-owned diabetic cats.
  
  
  METHODS
  Prospective, observational study. Simultaneous glucose profiles were generated over an 8-10 hour period using the CGMS, blood glucose concentration was measured every 2 hours with the PBGM. Profiles were submitted to three internal medicine specialists who used them to determine the insulin dose. Differences between insulin doses deduced from paired profiles were compared. Percentages of nadirs recorded with the CGMS that were lower, higher, or equal to those derived with the PBGM were calculated.
  
  
  RESULTS
  Twenty-one paired glucose profiles were obtained. There was no difference of insulin doses based on CGMS and PBGM profiles (median 0 U; range: -1 to +0.5). Treatment decisions did not differ among investigators. Compared with the observed PBGM nadir, the CGMS nadir was lower, higher, or equal in 17, 2, and 2 of 21 cases, respectively.
  
  
  CONCLUSIONS
  Adjustments in insulin dose based on glucose profiles generated with the CGMS are similar to those based on the PBGM. The common occurrence of lower nadirs recorded with the CGMS suggests that this device detects hypoglycemic periods that are not identified with the PBGM.
authors: Clinic for Small Animal Internal Medicine, University of Zurich, Zurich, Switzerland.
authors: S
authors: S
authors: Dietiker-Moretti
authors: C
authors: C
authors: Müller
authors: N
authors: N
authors: Sieber-Ruckstuhl
authors: F
authors: F
authors: Tschuor
authors: M
authors: M
authors: Osto
authors: M
authors: M
authors: Franchini
authors: M
authors: M
authors: Ackermann
authors: T A
authors: TA
authors: Lutz
authors: C E
authors: CE
authors: Reusch
authors: E
authors: E
authors: Zini
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D002371:Cat Diseases / Q000097:blood* / Q000188:drug therapy; D002415:Cats; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D018670:Monitoring, Ambulatory / Q000295:instrumentation / Q000662:veterinary*
chemical_list: D001786:Blood Glucose; D007328:Insulin