title: Cannabinomimetic lipid from a marine cyanobacterium.
abstract: NMR-guided fractionation of two independent collections of the marine cyanobacteria Lyngbya majuscula obtained from Papua New Guinea and Oscillatoria sp. collected in Panama led to the isolation of the new lipids serinolamide A (3) and propenediester (4). Their structures were determined by NMR and MS data analysis. Serinolamide A (3) exhibited a moderate agonist effect and selectivity for the CB1 cannabinoid receptor (Ki=1.3 μM, >5-fold) and represents the newest addition to the known cannabinomimetic natural products of marine origin.
authors: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography , and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States.
authors: Marcelino
authors: M
authors: Gutiérrez
authors: Alban R
authors: AR
authors: Pereira
authors: Hosana M
authors: HM
authors: Debonsi
authors: Alessia
authors: A
authors: Ligresti
authors: Vincenzo
authors: V
authors: Di Marzo
authors: William H
authors: WH
authors: Gerwick
mesh_terms: D000458:Cyanobacteria / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008055:Lipids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010176:Panama; D010219:Papua New Guinea; D043884:Receptor, Cannabinoid, CB1 / Q000819:agonists
chemical_list: D008055:Lipids; D043884:Receptor, Cannabinoid, CB1; C568802:propenediester lipid; C568801:serinolamide A