title: Sesquiterpenoids and lignans from the roots of Valeriana officinalis L.
abstract: Two new guaiane-type sesquiterpenoids, valerol A (1) and kessyl 3-acetate (2), together with nine known compounds, valeracetate (3), anismol A (4), orientalol C (5), spatulenol (6), 4α,10α-epoxyaromadendrane (7), (+)-8-hydroxypinoresinol (8), pinorespiol (9), pinoresinol 4-O-β-D-glucopyranoside (10), and 8-hydroxypinoresinol 4'-O-β-D-glucopyranoside (11) were isolated from the roots of Valeriana officinalis. The structures and relative configurations of 1 and 2 were elucidated on the basis of spectroscopic methods (1D- and 2D-NMR, MS, UV, and IR). These compounds were evaluated for inhibitory activity on acetylcholinesterase (AChE) and enhancing activity on nerve growth factor (NGF)-mediated neurite outgrowth in PC12 cells.
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, P. R. China.
authors: Peng-Cheng
authors: PC
authors: Wang
authors: Xin-Hui
authors: XH
authors: Ran
authors: Rui
authors: R
authors: Chen
authors: Huai-Rong
authors: HR
authors: Luo
authors: Qing-Yun
authors: QY
authors: Ma
authors: Yu-Qing
authors: YQ
authors: Liu
authors: Jiang-Miao
authors: JM
authors: Hu
authors: Sheng-Zhuo
authors: SZ
authors: Huang
authors: He-Zhong
authors: HZ
authors: Jiang
authors: Zhong-Quan
authors: ZQ
authors: Chen
authors: Jun
authors: J
authors: Zhou
authors: You-Xing
authors: YX
authors: Zhao
mesh_terms: D000818:Animals; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D005960:Glucosides / Q000737:chemistry; D017705:Lignans / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D020932:Nerve Growth Factor / Q000502:physiology; D016501:Neurites / Q000187:drug effects; D016716:PC12 Cells; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology*; D045789:Sesquiterpenes, Guaiane / Q000737:chemistry; D014632:Valerian / Q000737:chemistry*
chemical_list: C542293:8-hydroxypinoresinol; D002800:Cholinesterase Inhibitors; D005960:Glucosides; D017705:Lignans; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane; C530440:pinoresinol 4-O-glucopyranoside; D020932:Nerve Growth Factor