title: Urinary markers of nucleic acid oxidation and long-term mortality of newly diagnosed type 2 diabetic patients.
abstract: OBJECTIVE
  We analyzed data from a cohort of 1,381 newly diagnosed type 2 diabetic patients to test the hypothesis that urinary markers of nucleic acid oxidation are independent predictors of mortality.
  
  
  METHODS
  We examined the relationship between urinary excretion of markers of DNA oxidation (8-oxo-7,8-dihydro-2'-deoxyguanosine [8-oxodG]) and RNA oxidation (8-oxo-7,8-dihydroguanosine [8-oxoGuo]) and long-term mortality using Cox proportional hazards regression.
  
  
  RESULTS
  After multivariate adjustment, the hazard ratios for all-cause and diabetes-related mortality of patients with 8-oxoGuo levels in the highest quartile compared with those in the lowest quartile were 1.44 (1.12-1.85) and 1.54 (1.13-2.10), respectively. Conversely, no significant associations between 8-oxodG and mortality were found in the adjusted analyses.
  
  
  CONCLUSIONS
  Urinary excretion of the RNA oxidation marker 8-oxoGuo measured shortly after diagnosis of type 2 diabetes predicts long-term mortality independently of conventional risk factors. This finding suggests that 8-oxoGuo could serve as a new clinical biomarker in diabetes.
authors: Laboratory of Clinical Pharmacology, Rigshospitalet, Copenhagen, Denmark. kasper.broedbaek@rh.regionh.dk
authors: Kasper
authors: K
authors: Broedbaek
authors: Volkert
authors: V
authors: Siersma
authors: Trine
authors: T
authors: Henriksen
authors: Allan
authors: A
authors: Weimann
authors: Morten
authors: M
authors: Petersen
authors: Jon T
authors: JT
authors: Andersen
authors: Espen
authors: E
authors: Jimenez-Solem
authors: Elisabeth S
authors: ES
authors: Stovgaard
authors: Lars J
authors: LJ
authors: Hansen
authors: Jan Erik
authors: JE
authors: Henriksen
authors: Steen J
authors: SJ
authors: Bonnema
authors: Niels de Fine
authors: Nde F
authors: Olivarius
authors: Henrik E
authors: HE
authors: Poulsen
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D015415:Biomarkers / Q000652:urine*; D004249:DNA Damage; D003718:Denmark / Q000453:epidemiology; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000401:mortality* / Q000652:urine; D006151:Guanosine / Q000031:analogs & derivatives* / Q000652:urine; D006801:Humans; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology; D011379:Prognosis; D016016:Proportional Hazards Models; D012313:RNA / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D006151:Guanosine; C046215:8-hydroxyguanosine; D012313:RNA; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine