title: The role of oral contraception use in the occurrence of breast cancer. A retrospective study of 405 patients.
abstract: The investigation of potential predisposing factors of breast cancer, a disease accounting for almost one-third of malignancies in women, is necessary in order to reduce the incidence.
  
  
  METHODS
  We interviewed 405 female patients who had been diagnosed with breast cancer and who also reported having used oral contraceptive pills before. They were categorized into two groups (group A < 7 years OC use and group B > 7 years OC use).
  
  
  RESULTS
  Statistical analysis revealed a small (p < 0.02) but significant increased risk of the disease to BRCA mutation carriers, as well as to the women with a significant medical or family history of breast, ovarian or colon cancer who had also previously used oral contraceptive pills for more than seven years.
  
  
  CONCLUSIONS
  Breast cancer seems to be positively dependent on prolonged oral contraceptive use.
  
  
  CONCLUSIONS
  More research is needed to establish the hypothesis that the human genome is vulnerable to oral contraceptives.
authors: Technological Educational Institute of Athens, School of Midwifery, Athens, Greece.
authors: G
authors: G
authors: Iatrakis
authors: C
authors: C
authors: Iavazzo
authors: S
authors: S
authors: Zervoudis
authors: A
authors: A
authors: Koumousidis
authors: C
authors: C
authors: Sofoudis
authors: T
authors: T
authors: Kalampokas
authors: N
authors: N
authors: Salakos
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D003276:Contraceptives, Oral / Q000009:adverse effects*; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D020022:Genetic Predisposition to Disease; D006115:Greece / Q000453:epidemiology; D006579:Heterozygote; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D009369:Neoplasms / Q000235:genetics; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D003276:Contraceptives, Oral