title: Ocular complications of human immunodeficiency virus infection in eastern china.
abstract: OBJECTIVE
  To investigate ocular complications in patients with HIV/AIDS in eastern China during the time of highly active antiretroviral therapy (HAART).
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  This study was carried out from August 1, 2009 to July 31, 2010. Recruited HIV/AIDS patients underwent a series of surveys and ophthalmologic and laboratory examinations (including CD4 level) at enrollment.
  
  
  RESULTS
  In this study, all 787 HIV/AIDS patients (1574 eyes) had a history of HAART. Of these patients, 28.72% (95% CI = 0.26-0.32) had a history of systemic disease and 26.30% (95% CI = 0.23-0.29) had ocular complications. Of these ocular complications, cytomegalovirus retinitis (CMVR) had the highest prevalence (10.6%, 83/787) and ocular microangiopathy had the second-highest prevalence (9.4%, 74/787). Among the patients with CMVR, 16.9% (14/83) suffered from immune recovery uveitis (IRU). Furthermore, 3.4% (27/787) of the recruited AIDS patients had neuro-ophthalmologic disorders. The mean logMAR visual acuity of the group with ocular complications was 0.47 ± 0.64, which was significantly different from the asymptomatic group (0.17 ± 0.39, P < .001). The median CD4 T-cell count of the group with ocular complications is 43 cells/μL, which was significantly different from the asymptomatic group (116.5 cells/μL, P < .001).
  
  
  CONCLUSIONS
  The study shows a high rate of treatable ocular complications among patients with HIV/AIDS in eastern China. HIV/AIDS treatment programs in China must be prepared to identify ocular complications and refer patients to the correct treatment facilities.
authors: Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, PR China.
authors: Zhiliang
authors: Z
authors: Wang
authors: Renbing
authors: R
authors: Jia
authors: Shengfang
authors: S
authors: Ge
authors: Taiwen
authors: T
authors: He
authors: Yunzhi
authors: Y
authors: Zhang
authors: Yaling
authors: Y
authors: Yang
authors: Yefei
authors: Y
authors: Wang
authors: Wodong
authors: W
authors: Shi
authors: Yongrong
authors: Y
authors: Ji
authors: Fuxiang
authors: F
authors: Ye
authors: Ping
authors: P
authors: Chen
authors: Jianfeng
authors: J
authors: Lu
authors: Jing
authors: J
authors: Sun
authors: Xiaofang
authors: X
authors: Xu
authors: Yixiong
authors: Y
authors: Zhou
authors: Ping
authors: P
authors: Gu
authors: Min
authors: M
authors: Luo
authors: Hongzhou
authors: H
authors: Lu
authors: Xianqun
authors: X
authors: Fan
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002681:China / Q000453:epidemiology; D017726:Cytomegalovirus Retinitis / Q000453:epidemiology; D015828:Eye Infections, Viral / Q000188:drug therapy / Q000453:epidemiology* / Q000503:physiopathology; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D015861:Retinal Neovascularization / Q000453:epidemiology; D014605:Uveitis / Q000453:epidemiology; D014792:Visual Acuity / Q000502:physiology