title: CSF α-synuclein concentrations do not fluctuate over hours and are not correlated to amyloid β in humans.
abstract: Reports on the value of cerebrospinal fluid (CSF) α-synuclein as a biomarker for dementia with Lewy bodies and Parkinson disease are contradicting. This may be explained by fluctuating CSF α-synuclein concentrations over time. Such fluctuations have been suggested for CSF amyloid β concentrations. Furthermore, a physiological relationship between α-synuclein and amyloid β has been suggested based on in vitro research. We performed repeated CSF sampling in healthy elderly and AD patients and showed that sinusoidal fluctuations in CSF α-synuclein concentrations were not present. Furthermore, we did not find evidence for an interaction between amyloid β and α-synuclein concentrations in CSF.
authors: Department of Geriatric Medicine, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, and Alzheimer Centre, Nijmegen, The Netherlands. PetraESpies@gmail.com
authors: Petra E
authors: PE
authors: Spies
authors: Diane
authors: D
authors: Slats
authors: Marcel G M Olde
authors: MG
authors: Rikkert
authors: Jack
authors: J
authors: Tseng
authors: Jurgen A H R
authors: JA
authors: Claassen
authors: Marcel M
authors: MM
authors: Verbeek
mesh_terms: D000368:Aged; D000375:Aging / Q000134:cerebrospinal fluid; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid*; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D010446:Peptide Fragments / Q000134:cerebrospinal fluid*; D013997:Time Factors; D051844:alpha-Synuclein / Q000134:cerebrospinal fluid*
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; D051844:alpha-Synuclein; C078592:amyloid beta-protein (1-40); C075222:amyloid beta-protein (1-42)