title: PLGA/Ag nanocomposites: in vitro degradation study and silver ion release.
abstract: New nanocomposite films based on a biodegradable poly (DL-Lactide-co-Glycolide) copolymer (PLGA) and different concentration of silver nanoparticles (Ag) were developed by solvent casting. In vitro degradation studies of PLGA/Ag nanocomposites were conducted under physiological conditions, over a 5 week period, and compared to the behaviour of the neat polymer. Furthermore the silver ions (Ag(+)) release upon degradation was monitored to obtain information on the properties of the nanocomposites during the incubation. The obtained results suggest that the PLGA film morphology can be modified introducing a small percentage of silver nanoparticles that do not affect the degradation mechanism of PLGA polymer in the nanocomposite. However results clearly evinced the stabilizing effect of the Ag nanoparticles in the PLGA polymer and the mineralization process induced by the combined effect of silver and nanocomposite surface topography. The Ag(+) release can be controlled by the polymer degradation processes, evidencing a prolonged antibacterial effect.
authors: Materials Engineering Centre, UdR INSTM, NIPLAB, University of Perugia, Terni, Italy.
authors: E
authors: E
authors: Fortunati
authors: L
authors: L
authors: Latterini
authors: S
authors: S
authors: Rinaldi
authors: J M
authors: JM
authors: Kenny
authors: I
authors: I
authors: Armentano
mesh_terms: D020341:Absorbable Implants; D000890:Anti-Infective Agents / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry; D016503:Drug Delivery Systems; D007477:Ions; D019344:Lactic Acid / Q000737:chemistry*; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D053761:Nanocomposites / Q000737:chemistry*; D055095:Optics and Photonics; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry; D012834:Silver / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry
chemical_list: D000890:Anti-Infective Agents; D001672:Biocompatible Materials; D007477:Ions; D011108:Polymers; D012997:Solvents; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D012834:Silver