title: First case of congenital toxoplasmosis from Nepal.
abstract: Reportedly, nearly half of the Nepalese are Toxoplasma seropositive. However, neither the prevalence of congenital toxoplasmosis (CT) nor the confirmed case to CT is reported from Nepal yet. In this case report, we report the first case of CT in a 53 days old full term male baby (weight: 2,600 grams) delivered by caesarean section. The baby had hepatosplenomegaly and optic nerve coloboma with large scar in the right eye. The TORCH panel test showed significantly high Toxoplasma IgM antibody level (5.77 OD Ratio) compared with IgM antibody level against other agents. The baby was diagnosed as a case of CT and treatment was started accordingly. The baby, however, did not improve with the treatment and died after six days. The immediate cause of death was cardiorespiratory failure with antecedent cause of liver failure, renal insufficiency with thrombocytopenia.
authors: Department of Microbiology, Nepal Medical College and Teaching Hospital, Jorpati-7, Kathmandu, Nepal. drshibakrai@gmail.com
authors: S K
authors: SK
authors: Rai
authors: A
authors: A
authors: Sharma
authors: R K
authors: RK
authors: Shrestha
authors: P
authors: P
authors: Pradhan
mesh_terms: D000962:Antimalarials / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000008:administration & dosage; D004338:Drug Combinations; D017809:Fatal Outcome; D006801:Humans; D007223:Infant; D008297:Male; D009390:Nepal / Q000453:epidemiology; D011739:Pyrimethamine / Q000627:therapeutic use; D013413:Sulfadoxine / Q000627:therapeutic use; D014125:Toxoplasmosis, Congenital / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology
chemical_list: D000962:Antimalarials; D000981:Antiprotozoal Agents; D004338:Drug Combinations; C001205:fanasil, pyrimethamine drug combination; D013413:Sulfadoxine; D011739:Pyrimethamine