title: 5-Hydroxytryptophan attenuates somatic signs of nicotine withdrawal.
abstract: Abrupt nicotine cessation after chronic use disrupts monoaminergic systems and causes withdrawal signs/symptoms. In this study, the precursor of serotonin 5-hydroxytryptophan (5-HTP) relieved nicotine withdrawal signs. (-)-Nicotine bitartrate or equimolar sodium tartrate was infused into each rat via a s.c. osmotic minipump for 7 days. Somatic abstinence signs (teeth-chattering/chews and shakes, etc.) were counted one day after pump removal. Somatic signs were attenuated by the i.p. injection of 5-HTP, but not by NSD-1015, a centrally-acting L-aromatic amino acid decarboxylase inhibitor, indicating that 5-HTP mitigates somatic signs mainly through its conversion to 5-HT.
authors: Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109-0632, USA.
authors: Yu
authors: Y
authors: Ohmura
authors: Emily M
authors: EM
authors: Jutkiewicz
authors: Mitsuhiro
authors: M
authors: Yoshioka
authors: Edward F
authors: EF
authors: Domino
mesh_terms: D006916:5-Hydroxytryptophan / Q000627:therapeutic use*; D000818:Animals; D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D001522:Behavior, Animal / Q000187:drug effects; D006834:Hydrazines / Q000494:pharmacology; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018490:Serotonin Agents / Q000627:therapeutic use*; D016540:Smoking Cessation; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*
chemical_list: D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D006834:Hydrazines; D018490:Serotonin Agents; D009538:Nicotine; C004297:3-hydroxybenzylhydrazine; D006916:5-Hydroxytryptophan