title: It takes two to Get3.
abstract: Tail-anchored (TA) membrane proteins perform essential cellular functions. They are posttranslationally inserted into the endoplasmic reticulum (ER) membrane by interaction of the Get3 chaperone with the Get1/2 receptor. Two independent structural and functional analyses of the Get3/receptor complex by Stefer et al. and Mariappan et al. now provide insights into TA protein insertion.
authors: Heidelberg University Biochemistry Center, INF 328, 69120 Heidelberg, Germany. irmi.sinning@bzh.uni-heidelberg
authors: Irmgard
authors: I
authors: Sinning
authors: Gert
authors: G
authors: Bange
authors: Klemens
authors: K
authors: Wild