title: Effect of usnic acid on Candida orthopsilosis and C. parapsilosis.
abstract: The activity of usnic acid against Candida orthopsilosis and Candida parapsilosis on planktonic and biofilm conditions was investigated by using a broth microdilution and microplate methods. Potent in vitro activities against different Candida species were obtained. The metabolic activity of sessile cells of C. parapsilosis complex was reduced by 80% at four times the 80% inhibitory concentration. The in vitro studies support further efforts to determine whether usnic acid can be used clinically to cure patients with Candida infections.
authors: Universidade Estadual Paulista, UNESP, Araraquara, SP, Brazil. rehepi@gmail.com
authors: Regina Helena
authors: RH
authors: Pires
authors: Rodrigo
authors: R
authors: Lucarini
authors: Maria Jose Soares
authors: MJ
authors: Mendes-Giannini
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology; D001572:Benzofurans / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects / Q000254:growth & development; D002175:Candida / Q000187:drug effects* / Q000254:growth & development; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D010933:Plankton / Q000187:drug effects / Q000254:growth & development
chemical_list: D000935:Antifungal Agents; D001572:Benzofurans; C073339:usnic acid