title: Effect of blue-light filtering on multifocal visual-evoked potentials.
abstract: OBJECTIVE
  To perform an objective functional assessment of the impact of blue-light filters on cortical processing to evaluate the potential side effects of the filters on higher tier visual function at the neural level.
  
  
  METHODS
  Department of Ophthalmology, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
  
  
  METHODS
  Cohort study.
  
  
  METHODS
  Multifocal pattern-reversal visual-evoked potentials (multifocal VEPs) were recorded monocularly in pseudophakic patients with a clear intraocular lens (IOL) under 2 conditions: (1) stimulus perception through a yellow filter with the filter characteristics of an AF-1 YA-60BB IOL (blue filtering); (2) stimulus perception through a neutral filter that homogeneously attenuates the effective stimulus intensity as under the blue-light filtering condition but independent of the wavelength (neutral filtering). Second-order kernel multifocal VEPs were extracted for 60 visual field locations, and amplitude and latency effects were determined for 6 stimulus eccentricities.
  
  
  RESULTS
  The study evaluated 20 patients. Typical multifocal VEPs were obtained for the blue-light and neutral filtering conditions at all eccentricities. No significant effects on amplitudes were obtained, and a subtle latency effect (<0.5 millisecond delay for neutral filtering; P<.02) did not reach significance in an eccentricity-specific analysis.
  
  
  CONCLUSIONS
  The induced short-term change in the spectral composition of the visual stimulus left neural activity at the level of the primary visual cortex largely unaffected, providing an objective account of the integrity of visual processing under this condition.
authors: Universitäts-Augenklinik, Magdeburg, Germany. michael.hoffmann@med.ovgu.de
authors: Michael B
authors: MB
authors: Hoffmann
authors: Wolfgang
authors: W
authors: Behrens-Baumann
authors: Achim
authors: A
authors: Langenbucher
authors: Juliane
authors: J
authors: Reupsch
authors: Arne
authors: A
authors: Viestenz
mesh_terms: D000368:Aged; D015331:Cohort Studies; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D006801:Humans; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification; D011474:Prosthesis Design; D019591:Pseudophakia / Q000503:physiopathology*; D012160:Retina / Q000502:physiology; D055351:Retinal Neurons / Q000502:physiology; D014792:Visual Acuity / Q000502:physiology; D014793:Visual Cortex / Q000502:physiology