title: Donor-recipient gender mismatch affects early graft loss after kidney transplantation.
abstract: BACKGROUND
  We sought to determine the risk factors influencing the occurrence of early graft loss among kidney transplant recipients.
  
  
  METHODS
  One hundred forty-six potential donors and 230 kidney recipients were included in the study. Prior to organ procurement we collected demographic data as well as hemodynamic data of mean arterial pressure, central venous pressure, pulmonary capillary wedge pressure, systemic vascular resistance index acquired by means of a thermodilution method. The recipient data included age, gender, prior hemodialysis period, panel-reactive antibodies, cold ischemia time, renal insufficiency cause, and donor-recipient gender mismatch. We assessed the influence of the data on graft loss at 30 days after renal transplantation. To confirm the relationships, we performed statistical analyses using chi-square, Fisher exact, and V. Cramer tests.
  
  
  RESULTS
  There were no significant relationships between the analyzed parameters and early graft loss in the study group except for gender mismatch. The 71 female recipients of male kidneys showed the lowest graft survival: donor/recipient male/female 89%; donor/recipient female/male 97%; no mismatch 97% (P=.01).
  
  
  CONCLUSIONS
  Female recipients of male kidneys may experience a greater risk of early graft loss compared with all other gender combinations.
authors: Department of Anaesthesiology and Intensive Care, Pomeranian Medical University, Szczecin, Poland. zukowski@pum.edu.pl
authors: M
authors: M
authors: Zukowski
authors: K
authors: K
authors: Kotfis
authors: J
authors: J
authors: Biernawska
authors: M
authors: M
authors: Zegan-Barańska
authors: M
authors: M
authors: Kaczmarczyk
authors: A
authors: A
authors: Ciechanowicz
authors: M
authors: M
authors: Brykczyński
authors: M
authors: M
authors: Ostrowski
authors: T
authors: T
authors: Nikodemski
authors: R
authors: R
authors: Bohatyrewicz
mesh_terms: D000328:Adult; D005260:Female; D006084:Graft Rejection / Q000209:etiology*; D006085:Graft Survival; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012727:Sex Characteristics; D013997:Time Factors; D014019:Tissue Donors; D009927:Tissue and Organ Procurement