title: Amyloid β induces adhesion of erythrocytes to endothelial cells and affects endothelial viability and functionality.
abstract: It has been suggested that amyloid β-peptide (Aβ) might mediate the adhesion of erythrocytes to the endothelium which could disrupt the properties of endothelial cells. We provide evidence here that Aβ actually induced the binding of erythrocytes to endothelial cells and decreased endothelial viability, perhaps by the generation of oxidative and inflammatory stress. These changes are likely to contribute to the pathogenesis of Alzheimer's disease.
authors: Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan. nkgw@biochem.tohoku.ac.jp
authors: Kiyotaka
authors: K
authors: Nakagawa
authors: Takehiro
authors: T
authors: Kiko
authors: Satoko
authors: S
authors: Kuriwada
authors: Taiki
authors: T
authors: Miyazawa
authors: Fumiko
authors: F
authors: Kimura
authors: Teruo
authors: T
authors: Miyazawa
mesh_terms: D016229:Amyloid beta-Peptides / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects*; D004912:Erythrocytes / Q000166:cytology* / Q000187:drug effects*; D061307:Human Umbilical Vein Endothelial Cells / Q000166:cytology* / Q000187:drug effects*; D006801:Humans; D008297:Male; D013997:Time Factors; D055815:Young Adult
chemical_list: D016229:Amyloid beta-Peptides