title: Can Chiari malformation negatively affect higher mental functioning in developmental age?
abstract: Numerous studies on adults have confirmed that the cerebellum has a role in processing higher brain functions, and evidence of this role has emerged more recently in developmental age as well. Various types of congenital lesion are associated with neuropsychological impairments and behavioral changes that can sometimes even give rise to a picture of autism. Acquired cerebellar lesions (especially tumors and stroke) in children of normal intelligence have enabled different neuropsychological profiles to be identified, depending on the cerebellar site involved. In Chiari malformation, the cerebellar structures are squeezed and crowded inside the posterior fossa and along the time this could generate various kinds of cognitive and behavioral disorders. Currently available data remain inconclusive, however, and prospective longitudinal studies on sizable series will be needed to ascertain whether and to what degree Chiari malformations may negatively affect mental functioning in developmental age.
authors: UO Neurologia dello Sviluppo, Fondazione IRCCS Istituto Neurologico C. Besta, Via Celoria 11, 20133, Milan, Italy. driva@istituto-besta.it
authors: Daria
authors: D
authors: Riva
authors: Arianna
authors: A
authors: Usilla
authors: Veronica
authors: V
authors: Saletti
authors: Sivia
authors: S
authors: Esposito
authors: Sara
authors: S
authors: Bulgheroni
mesh_terms: D000293:Adolescent; D001139:Arnold-Chiari Malformation / Q000150:complications*; D002675:Child, Preschool; D003072:Cognition Disorders / Q000209:etiology*; D002658:Developmental Disabilities / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male