title: Regenerative biomaterials that "click": simple, aqueous-based protocols for hydrogel synthesis, surface immobilization, and 3D patterning.
abstract: The click chemistry era has generated a library of versatile "spring-loaded" reactions that offer high yields, regio- and stereospecificity, and outstanding functional group tolerance. These powerful transformations are particularly advantageous for the design of sophisticated biomaterials that require high levels of precision and control, namely, materials that promote tissue regeneration such as hydrogels, 2D functionalized substrates, and 3D biomimetic scaffolds. In this review, the synthesis and application of regenerative biomaterials via click chemistry are summarized. Particular emphasis is placed on the copper(I)-catalyzed alkyne-azide cycloaddition, Diels-Alder cycloadditions, and thiol-click coupling.
authors: The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada.
authors: Chelsea M
authors: CM
authors: Nimmo
authors: Molly S
authors: MS
authors: Shoichet
mesh_terms: D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry*; D057930:Click Chemistry / Q000379:methods*; D003300:Copper / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D020100:Hydrogels / Q000138:chemical synthesis* / Q000737:chemistry*; D008301:Maleimides / Q000737:chemistry; D015394:Molecular Structure; D012038:Regeneration; D044968:Regenerative Medicine / Q000379:methods; D013438:Sulfhydryl Compounds / Q000737:chemistry; D013499:Surface Properties; D023822:Tissue Engineering / Q000379:methods; D014867:Water / Q000737:chemistry*
chemical_list: D000480:Alkynes; D001386:Azides; D001672:Biocompatible Materials; D020100:Hydrogels; D008301:Maleimides; D013438:Sulfhydryl Compounds; D014867:Water; D003300:Copper