title: New icetexane diterpenes with intestinal α-glucosidase inhibitory and free-radical scavenging activity isolated from Premna tomentosa roots.
abstract: New icetexane diterpenes (1-2); 8, 11, 13-icetexatriene-10-hydroxy, 11, 12, 16-tri acetoxyl (1) and 8, 11, 13-icetexatriene-7, 10, 11-dihydroxy-12, 13-dihydrofuran (2) along with six known compounds namely acetoxy syranzaldehyde (3), syranzaldehyde (4), coniferaldehyde (5), lupeol (6), betulin (7), and 4-(4-methoxy phenyl)-2-butanone (8) were isolated from the roots of Premna tomentosa. The structures of compounds 1 and 2 were established by detailed spectral analysis using UV, IR, (1)H NMR, (13)C NMR, 1D, 2D and Mass. The newly isolated compounds were screened for rat intestinal α-glucosidase inhibitory and free radical (DPPH) scavenging potentiality. The new icetexane diterpenes (1, 2) and compound 3 were found to have significant α-glucosidase inhibitory and also free radical scavenging (DPPH) activities.
authors: Mahatma Gandhi University, Nalgonda-508001, A.P, India. asriict@gmail.com
authors: Sridhar Rao
authors: SR
authors: Ayinampudi
authors: Ramesh
authors: R
authors: Domala
authors: Ramchander
authors: R
authors: Merugu
authors: Sreenivasulu
authors: S
authors: Bathula
authors: Madhusudana Rao
authors: MR
authors: Janaswamy
mesh_terms: D000818:Animals; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D007422:Intestines / Q000201:enzymology; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D051381:Rats; D029648:Verbenaceae / Q000737:chemistry*
chemical_list: D004224:Diterpenes; D016166:Free Radical Scavengers; D065089:Glycoside Hydrolase Inhibitors