title: Acute psychosis after paclitaxel infusion.
abstract: Paclitaxel (PTX) is a widely used antineoplastic agent against a variety of cancers. The common side effects are myelosuppression and peripheral neurotoxicity. There have been occasional instances of central nervous system toxicity after PTX treatment though the syndrome is not well described. We report a patient undergoing treatment for laryngeal cancer who experienced mental status changes and psychosis after each cycle of PTX and carboplatin, lasting for less than a day. In a subsequent cycle excluding PTX, these symptoms did not recur.
authors: Department of Internal Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA. naush2003@yahoo.com
authors: Nausheen
authors: N
authors: Ahmed
authors: Saad
authors: S
authors: Usmani
authors: Nicola
authors: N
authors: Jabbour
authors: Upendra
authors: U
authors: Hegde
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D016190:Carboplatin / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D007260:Infusion Pumps; D007822:Laryngeal Neoplasms / Q000188:drug therapy; D008297:Male; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects*; D010300:Parkinson Disease / Q000150:complications; D011618:Psychotic Disorders / Q000209:etiology*; D012307:Risk Factors
chemical_list: D016190:Carboplatin; D017239:Paclitaxel