title: The influence of vascular endothelial growth factor (VEGF) polymorphism on the progression of chronic glomerulonephritides.
abstract: Vascular endothelial growth factor is an             important mediator in maintaining normal kidney             functions. In addition, several lines of evidence show             that up-regulation of this mediator in glomeruli may             be associated with or may directly cause renal dysfunction.             We tried to assess the influence of the -2578             C/A and -1154 G/A polymorphisms in the regulatory             region of the vascular endothelial growth factor gene             upon progression of three primary chronic glomerulonephritides             (minimal change disease/focal and segmental             glomerulosclerosis, membranous nephropathy,             immunoglobulin A nephropathy). We studied a             cohort of 213 patients compared to 311 unrelated             healthy controls. Analysis of the C/A polymorphism             of vascular endothelial growth factor revealed an increased             prevalence of CC genotype in the minimal             change disease/focal and segmental glomerulosclerosis             group in comparison with the other groups. A balanced             distribution of G and A alleles among the respective             types of chronic glomerulonephritides was             shown in the analysis of -1154 G/A polymorphism.             Finally, we have not proved any significant influence             of the polymorphisms at positions -2578 C/A and             -1154 G/A of the vascular endothelial growth factor             gene promoter on the progression of chronic glomerulonephritides             even though our study suggests a negative             effect of CC genotype of -2578 C/A polymorphism             on the clinical course of minimal change             disease/focal segmental glomerulosclerosis.
authors: Department of Nephrology, Charles University in Prague and General University Hospital in Prague, Czech Republic. diebo@email.cz
authors: H
authors: H
authors: Safránková
authors: M
authors: M
authors: Merta
authors: J
authors: J
authors: Reiterová
authors: J
authors: J
authors: Stekrová
authors: D
authors: D
authors: Maixnerová
authors: R
authors: R
authors: Ryšavá
authors: J
authors: J
authors: Skibová
authors: V
authors: V
authors: Tesař
mesh_terms: D000328:Adult; D002908:Chronic Disease; D018450:Disease Progression; D005260:Female; D005838:Genotype; D005921:Glomerulonephritis / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: D042461:Vascular Endothelial Growth Factor A