title: Association of interleukin-11 with mortality in patients with spontaneous basal ganglia haemorrhage.
abstract: This study evaluated interleukin (IL)-11 as an independent prognostic marker of mortality following intracerebral haemorrhage (ICH). Plasma IL-11 levels in patients with ICH were significantly higher than in healthy controls. Multivariate analysis indicated that plasma IL-11 level was  an independent predictor for mortality within 1 week of ICH onset and was positively associated with haematoma volume. Receiver operating characteristic curve analysis identified that a baseline plasma IL-11 level > 20.9 pg/ml predicted mortality within 1 week of ICH onset with 81.2% sensitivity  and 74.1% specificity. The area under the curve for IL-11 level was significantly smaller than that for the Glasgow Coma Scale score, but similar to that for haematoma volume. IL-11 did not, however, significantly improve the predictive value of the Glasgow Coma Scale or haematoma volume.  Thus, IL-11 may be considered as a new independent prognostic marker of mortality and an additional valuable tool for risk stratification and decision-making in the acute phase of ICH.
authors: Department of Neurosurgery, Shaoxing County Central Hospital, Shaoxing, China.
authors: C J
authors: CJ
authors: Tu
authors: W G
authors: WG
authors: Liu
authors: X Q
authors: XQ
authors: Dong
authors: J S
authors: JS
authors: Liu
authors: D G
authors: DG
authors: Song
authors: W H
authors: WH
authors: Yu
authors: Z Y
authors: ZY
authors: Zhang
authors: G
authors: G
authors: Zhen
authors: H M
authors: HM
authors: Lou
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020145:Basal Ganglia Hemorrhage / Q000097:blood* / Q000401:mortality* / Q000473:pathology; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017370:Interleukin-11 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012372:ROC Curve; D015996:Survival Rate
chemical_list: D017370:Interleukin-11