title: Indicators associated with coronary atherosclerosis in metabolic syndrome.
abstract: BACKGROUND
  Metabolic factors associated with coronary atherosclerosis (CA) in metabolic syndrome (MetS) remain unclear.
  
  
  METHODS
  A total of 550 consecutive subjects without documented coronary artery disease who received contrast-enhanced coronary computed tomography angiography were analyzed. CA was defined as coronary artery calcification (CAC) scores >0 or, zero CAC score combining noncalcified plaques within the proximal third segment of major coronary arteries. Metabolic factors and novel atherosclerotic biomarkers including high-sensitive C-reactive protein (hs-CRP) and adiponectin were measured. MetS was recognized according to the ethnicity-specific National Cholesterol Educational Program Adult Treatment Panel III, 2001.
  
  
  RESULTS
  After adjusted with novel atherosclerotic biomarkers, MetS was significantly associated with CA Odds ratio [OR], 2.88; 95% confidence interval [CI], 1.88 to 4.42; p<0.001). Subgroup analysis revealed that fasting blood glucose ≥ 110 mg/dl/diabetes mellitus in non-MetS subjects (OR, 1.40; 95%CI, 1.08 to 1.82; p<0.05) and total cholesterol (TC)/high density lipoprotein-cholesterol (HDL-C) ≥ 4.2 in MetS subjects (OR, 4.44; 95%CI, 1.93 to 10.20; p<0.001) were independently associated with CA. Both indicators were significantly associated with increased serum hs-CRP and reduced adiponectin levels in all subjects.
  
  
  CONCLUSIONS
  MetS is independently associated with CA after adjustment of atherosclerotic biomarkers. TC/HDL-C ≥ 4.2 in MetS and fasting blood glucose ≥ 110 mg/dl/diabetes mellitus in non-MetS subjects are independent indicators of CA, suggesting the potential difference in pathophysiology of CA.
authors: Cardiovascular Research Center, and School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC.
authors: Ting-Yu
authors: TY
authors: Chiu
authors: Ching-Yuan
authors: CY
authors: Chen
authors: Shan-Yin
authors: SY
authors: Chen
authors: Chang-Chieng
authors: CC
authors: Soon
authors: Jaw-Wen
authors: JW
authors: Chen
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications*; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D008055:Lipids