title: Morning glory resin glycosides as modulators of antibiotic activity in multidrug-resistant gram-negative bacteria.
abstract: Twenty-six microbiologically inactive (MIC > 512 µg/mL) convolvulaceous resin glycosides ( 1- 26) were tested for resistance modulatory activity in vitro against Escherichia coli Rosetta-gami and two nosocomial pathogens, Salmonella typhi and Shigella flexneri. These compounds exerted a potentiation effect of the clinically useful antibiotics tetracycline, kanamycin, and chloramphenicol against the tested gram-negative bacteria by increasing antibiotic susceptibility up to 32-fold at concentrations of 25 µg/mL. Therefore, the oligosaccharides from the morning glory family (Convolvulaceae) represent metabolites that reverse microbial resistance mechanisms, favoring an increase in the strength and effectiveness of current antibiotics that are not effective in the treatment of refractive infections caused by multidrug-resistant strains.
authors: Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City, Mexico.
authors: Berenice
authors: B
authors: Corona-Castañeda
authors: Rogelio
authors: R
authors: Pereda-Miranda
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002701:Chloramphenicol / Q000494:pharmacology; D004351:Drug Resistance / Q000187:drug effects*; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects; D006027:Glycosides / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D027741:Ipomoea / Q000737:chemistry*; D007612:Kanamycin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009844:Oligosaccharides / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D012116:Resins, Plant / Q000494:pharmacology*; D012475:Salmonella / Q000187:drug effects; D012760:Shigella / Q000187:drug effects; D013752:Tetracycline / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D006027:Glycosides; D009844:Oligosaccharides; D010936:Plant Extracts; D012116:Resins, Plant; D007612:Kanamycin; D002701:Chloramphenicol; D013752:Tetracycline