title: Of dogs and men: comparative biology as a tool for the discovery of novel biomarkers and drug development targets in osteosarcoma.
abstract: The similarities between human and canine osteosarcoma with regard to histology, biological behavior and molecular genetic alterations suggest that the dog provides a supplementary model for the development and preclinical testing of novel therapeutics. Counter intuitively, careful examination of the differences between OS in the two species may also be rewarding in terms of increasing our understanding of the pathogenesis of this cancer. This review will discuss the arguments in favor of the "dog model" and outline how the evaluation of treatment strategies in dogs has indicated avenues for improvement of protocols for human patients.
authors: Sarcoma Research Group, Northern Institute for Cancer Research, Newcastle University and North of England Bone and Soft Tissue Sarcoma Service, Framlington Place, Newcastle-Upon-Tyne, UK.
authors: Kenneth S
authors: KS
authors: Rankin
authors: Mike
authors: M
authors: Starkey
authors: John
authors: J
authors: Lunec
authors: Craig H
authors: CH
authors: Gerrand
authors: Sue
authors: S
authors: Murphy
authors: Swethajit
authors: S
authors: Biswas
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000503:physiopathology / Q000662:veterinary*; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000503:physiopathology*; D004285:Dogs; D055808:Drug Discovery; D006801:Humans; D023821:Limb Salvage; D058990:Molecular Targeted Therapy; D012516:Osteosarcoma / Q000188:drug therapy* / Q000503:physiopathology / Q000662:veterinary*; D010828:Physiology, Comparative; D057170:Translational Research, Biomedical
chemical_list: D014408:Biomarkers, Tumor