title: Small lymphocytic lymphoma in a patient with CREST syndrome.
abstract: We report a case of a 61-year-old man with a history of CREST syndrome (calcinosis cutis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia) who presented for evaluation of thrombocytopenia. He had evident cervical adenopathy and lymph node biopsy showed small lymphocytic lymphoma (SLL) with evident systemic adenopathy and bone marrow involvement. The patient achieved a complete remission with FCR (fludarabine/cyclophosphamide/rituximab) chemotherapy. About 30 cases of lymphomas are reported in the literature in association with systemic sclerosis. To our knowledge, there are no reports of a small lymphocytic lymphoma (SLL) in association with limited cutaneous systemic sclerosis with classic features of the CREST syndrome.
authors: University of Nebraska Medical Center and Omaha Veterans Affairs Medical Center, Omaha, Nebraska 68198-7680, USA. bwillia@unmc.edu
authors: Basem M
authors: BM
authors: William
authors: Tracey
authors: T
authors: Harbert
authors: Apar K
authors: AK
authors: Ganti
authors: Philip J
authors: PJ
authors: Bierman
mesh_terms: D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D017675:CREST Syndrome / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D002449:Cell Aggregation; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology / Q000601:surgery; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed