title: Electroactive porous tubular scaffolds with degradability and non-cytotoxicity for neural tissue regeneration.
abstract: Electroactive degradable porous tubular scaffolds were fabricated from the blends of polycaprolactone and a hyperbranched degradable conducting copolymer at different feed ratios by a solution-casting/salt-leaching method. Scaning electron microscopy (SEM) and microcomputed tomography tests indicated that these scaffolds had homogeneously distributed interconnected pores on the cross-section and surface. The electrical conductivity of films with the same composition as the scaffolds was between 3.4×10(-6) and 3.1×10(-7) S cm(-1), depending on the ratio of hyperbranched degradable conducting copolymer to polycaprolactone. A hydrophilic surface with a contact angle of water about 30° was achieved by doping the films with (±)-10-camphorsulfonic acid. The mechanical properties of the films were investigated by tensile tests, and the morphology of the films was studied by SEM. The scaffolds were subjected to the WST test (a cell proliferation and cytotoxicity assay using water-soluble tetrazolium salts) with HaCaT keratinocyte cells, and the results show that these scaffolds are non-cytotoxic. These degradable electroactive tubular scaffolds are good candidates for neural tissue engineering application.
authors: Department of Fibre and Polymer Technology, School of Chemical Science and Engineering, Royal Institute of Technology, Stockholm, Sweden.
authors: Baolin
authors: B
authors: Guo
authors: Yang
authors: Y
authors: Sun
authors: Anna
authors: A
authors: Finne-Wistrand
authors: Kamal
authors: K
authors: Mustafa
authors: Ann-Christine
authors: AC
authors: Albertsson
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism*; D002460:Cell Line; D004553:Electric Conductivity; D015603:Keratinocytes / Q000166:cytology / Q000378:metabolism; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D009416:Nerve Regeneration / Q000502:physiology*; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D016062:Porosity; D013499:Surface Properties; D013718:Tensile Strength; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds / Q000737:chemistry*; D055114:X-Ray Microtomography
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C016240:polycaprolactone