title: Impact of the HYPITAT trial on doctors' behaviour and prevalence of eclampsia in the Netherlands.
abstract: We questioned if participation in the HYPITAT trial (induction of labour versus expectant monitoring in women with gestational hypertension or pre-eclampsia at term) impacted implementation of its results and subsequently maternal health. We identified women with hypertensive disease from the Perinatal Registry, and distinguished the period before, during and after the trial. We included 43 641 women. Induction of labour increased from 58.3 to 67.1% (P < 0.001) and prevalence of eclampsia decreased from 0.85 to 0.19% (P < 0.001) before and after the trial. Concurrently, participation in the HYPITAT trial among others had immediate consequences for obstetric management and maternal health.
authors: Department of Obstetrics and Gynaecology, University Medical Centre Groningen, Groningen, the Netherlands. k.van.der.tuuk@og.umcg.nl
authors: K
authors: K
authors: van der Tuuk
authors: C M
authors: CM
authors: Koopmans
authors: H
authors: H
authors: Groen
authors: B W
authors: BW
authors: Mol
authors: M G
authors: MG
authors: van Pampus
mesh_terms: D036861:Delivery, Obstetric / Q000706:statistics & numerical data; D004461:Eclampsia / Q000453:epidemiology / Q000628:therapy*; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000628:therapy; D007751:Labor, Induced / Q000706:statistics & numerical data; D007743:Labor, Obstetric; D015337:Multicenter Studies as Topic; D009426:Netherlands / Q000453:epidemiology; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*; D011225:Pre-Eclampsia / Q000628:therapy; D011247:Pregnancy; D011295:Prenatal Care / Q000379:methods*; D015995:Prevalence; D016032:Randomized Controlled Trials as Topic