title: Antitumour effect of Diospyros cordifolia bark on Ehrlich ascites carcinoma-bearing Swiss albino mice.
abstract: Diospyros cordifolia Roxb. (Ebenaceae), commonly known as Indian ebony, is used traditionally for several medicinal purposes. In this study, the methanol extract of D. cordifolia bark (MEDC) was evaluated for its antitumour effect against Ehrlich ascites carcinoma (EAC)-bearing Swiss albino mice. Twenty-four hours after intraperitoneal inoculation of tumour (EAC) cells in mice, MEDC was administered intraperitoneally at 25 and 50 mg kg⁻¹ bodyweight for 9 consecutive days. On the 10th day, half of the mice were sacrificed to determine the tumour volume, viable and non-viable tumour cell counts, and rest were kept alive for the assessment of median survival time and increase in life span. Haematological profiles were also determined. MEDC exhibited a marked decrease in tumour growth parameters and increased the survival rate of EAC-bearing animals. MEDC normalised the haematological parameters as compared with the EAC control mice. Therefore, this study demonstrated that D. cordifolia bark possessed remarkable antitumour efficacy.
authors: Netaji Subhas Chandra Bose Institute of Pharmacy, Chakdaha, Nadia 741222, West Bengal, India.
authors: Sudipta
authors: S
authors: Das
authors: Sanjib
authors: S
authors: Bhattacharya
authors: Goutam
authors: G
authors: Pramanik
authors: Pallab Kanti
authors: PK
authors: Haldar
mesh_terms: D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000178:diet therapy*; D029788:Diospyros / Q000737:chemistry*; D051379:Mice; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000627:therapeutic use*
chemical_list: D010936:Plant Extracts