title: Spleen: A new role for an old player?
abstract: The spleen could be considered a neglected organ. To date, it has been deemed an ancillary organ in portal hypertension or an organ localization in lymphoproliferative diseases, even though it has had significant attention in infectious diseases for some time. Now, it is thought to be central in regulating the immune system, a metabolic asset and involved in endocrine function with regard to nonalcoholic fatty liver disease. The main mechanisms involved in this complex network will be critically discussed in this article.
authors: Department of Clinical and Experimental Medicine, Federico II University Medical School of Naples, Via S. Pansini 5 80131 Naples, Italy. tarantin@unina.it
authors: Giovanni
authors: G
authors: Tarantino
authors: Silvia
authors: S
authors: Savastano
authors: Domenico
authors: D
authors: Capone
authors: Annamaria
authors: A
authors: Colao
mesh_terms: D000818:Animals; D005234:Fatty Liver / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D006728:Hormones / Q000378:metabolism; D006801:Humans; D008103:Liver Cirrhosis / Q000473:pathology / Q000503:physiopathology; D018377:Neurotransmitter Agents / Q000378:metabolism; D065626:Non-alcoholic Fatty Liver Disease; D013154:Spleen / Q000033:anatomy & histology / Q000276:immunology / Q000502:physiology; D014807:Vitamin D / Q000378:metabolism
chemical_list: D006728:Hormones; D018377:Neurotransmitter Agents; D014807:Vitamin D