title: Maternal exposure to high levels of dioxins in relation to birth weight in women affected by Yusho disease.
abstract: BACKGROUND
  Studies on the association of maternal exposure to polychlorinated dibenzo-p-dioxin (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) with decreased birth weight in humans have produced conflicting results. In Japan in 1968, an accidental human exposure to rice oil contaminated with PCDDs, PCDFs, and PCBs, led to the development of Yusho disease.
  
  
  OBJECTIVE
  The Yusho cohort was used to evaluate the effect of maternal exposure to PCDDs, PCDFs, and PCBs on birth weight.
  
  
  METHODS
  Blood samples, obtained from 101 Yusho women (190 births) who gave birth after exposure, were analyzed for congeners of seven PCDDs, ten PCDFs, and four non-ortho PCBs.
  
  
  RESULTS
  Total PCDD TEQ (adjusted beta=-161.9g; 95% CI, -265.3 to -58.6), total PCDF TEQ (adjusted beta=-105.9g; 95% CI, -179.5 to -32.2), and total non-ortho PCBs (adjusted beta=-178.4g; 95% CI, -318.3 to -38.5) levels were inversely associated with birth weight. Significant inverse associations with birth weight were also found for total PCDD TEQ, total PCDF TEQ, and total non-ortho PCB TEQ levels among male, but not female, infants. Significant inverse associations with birth weight were also found for nine congeners among all infants; the adjusted beta coefficients were largest for 1,2,3,6,7,8-HxCDD and smallest for 2,3,4,7,8-PeCDF.
  
  
  CONCLUSIONS
  In the setting of exposure to high levels of dioxins, maternal blood levels of PCDDs, PCDFs and PCBs are associated with lower birth weight in Yusho patients. The association exhibited gender-specific differences, as male infants are more susceptible than females to growth restriction induced by in utero dioxin exposures.
authors: Department of Obstetrics, Fukuoka Children's Hospital, Japan. tsukimori.k@fcho.jp
authors: Kiyomi
authors: K
authors: Tsukimori
authors: Hiroshi
authors: H
authors: Uchi
authors: Chikage
authors: C
authors: Mitoma
authors: Fumiko
authors: F
authors: Yasukawa
authors: Takahito
authors: T
authors: Chiba
authors: Takashi
authors: T
authors: Todaka
authors: Junboku
authors: J
authors: Kajiwara
authors: Takesumi
authors: T
authors: Yoshimura
authors: Teruaki
authors: T
authors: Hirata
authors: Kotaro
authors: K
authors: Fukushima
authors: Norio
authors: N
authors: Wake
authors: Masutaka
authors: M
authors: Furue
mesh_terms: D000328:Adult; D001572:Benzofurans / Q000097:blood; D001724:Birth Weight / Q000187:drug effects*; D015331:Cohort Studies; D000072338:Dibenzofurans, Polychlorinated; D004147:Dioxins / Q000097:blood*; D005260:Female; D005506:Food Contamination; D006801:Humans; D007223:Infant; D007564:Japan / Q000453:epidemiology; D008297:Male; D018811:Maternal Exposure / Q000706:statistics & numerical data*; D012275:Oryza / Q000009:adverse effects; D011078:Polychlorinated Biphenyls / Q000097:blood; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives / Q000097:blood; D011164:Porphyrias / Q000139:chemically induced* / Q000453:epidemiology; D055815:Young Adult
chemical_list: D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins; D011078:Polychlorinated Biphenyls; C020887:dibenzo(1,4)dioxin