title: Restenosis after PCI. Part 2: prevention and therapy.
abstract: The techniques and materials used during percutaneous coronary intervention have advanced considerably over the past 3 decades, yet restenosis remains one of the major drawbacks of this procedure. Many innovative technologies, including drug-eluting stents, with or without specific polymers, and fully biodegradable stents have been and continue to be developed in the search for a safe and effective antirestenosis therapy. Remarkable advances in stent design and nanoparticle delivery systems ('nanovehicles') have already fueled revolutionary changes in the prevention and treatment of in-stent restenosis. In this Review we provide an overview of the latest innovations for optimizing outcomes of coronary stenting, and up-to-date information about prevention and treatment of in-stent restenosis.
authors: Department of Cardiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands. j.w.jukema@lumc.nl
authors: J Wouter
authors: JW
authors: Jukema
authors: Tarek A N
authors: TA
authors: Ahmed
authors: Jeffrey J W
authors: JJ
authors: Verschuren
authors: Paul H A
authors: PH
authors: Quax
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000379:methods* / Q000639:trends; D023903:Coronary Restenosis / Q000517:prevention & control*; D054855:Drug-Eluting Stents; D006801:Humans; D053758:Nanoparticles / Q000627:therapeutic use; D011474:Prosthesis Design; D016896:Treatment Outcome