title: Intrinsic magnetism and hyperthermia in bioactive Fe-doped hydroxyapatite.
abstract: The use of magnetic activation has been proposed to answer the growing need for assisted bone and vascular remodeling during template/scaffold regeneration. With this in mind, a synthesis procedure was developed to prepare bioactive (Fe2+/Fe3+)-doped hydroxyapatite (Fe-HA), endowed with superparamagnetic-like properties. This new class of magnetic hydroxyapatites can be potentially employed to develop new magnetic ceramic scaffolds with enhanced regenerative properties for bone surgery; in addition, magnetic Fe-HA can find application in anticancer therapies, to replace the widely used magnetic iron oxide nanoparticles, whose long-term cytotoxicity was recently found to reach harmful levels. An extensive physicochemical, microstructural and magnetic characterization was performed on the obtained Fe-HA powders, and demonstrated that the simultaneous addition of Fe2+ and Fe3+ ions during apatite nucleation under controlled synthesis conditions induces intrinsic magnetization in the final product, minimizing the formation of magnetite as secondary phase. This result potentially opens new perspectives for biodevices aimed at bone regeneration and for anti-cancer therapies based on hyperthermia.
authors: Institute of Science and Technology for Ceramics-National Research Council, Faenza (RA) 48018, Italy. anna.tampieri@istec.cnr.it
authors: Anna
authors: A
authors: Tampieri
authors: Teresa
authors: T
authors: D'Alessandro
authors: Monica
authors: M
authors: Sandri
authors: Simone
authors: S
authors: Sprio
authors: Elena
authors: E
authors: Landi
authors: Luca
authors: L
authors: Bertinetti
authors: Silvia
authors: S
authors: Panseri
authors: Giancarlo
authors: G
authors: Pepponi
authors: Joerg
authors: J
authors: Goettlicher
authors: Manuel
authors: M
authors: Bañobre-López
authors: Jose
authors: J
authors: Rivas
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects; D017886:Durapatite / Q000737:chemistry* / Q000494:pharmacology; D006358:Hot Temperature; D007501:Iron / Q000737:chemistry* / Q000494:pharmacology; D060526:Magnetic Fields; D008280:Magnetics; D046529:Microscopy, Electron, Transmission; D008856:Microscopy, Fluorescence; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects; D010084:Oxidation-Reduction / Q000187:drug effects; D011208:Powders; D011817:Rabbits; D056928:X-Ray Absorption Spectroscopy; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D011208:Powders; D017886:Durapatite; D007501:Iron