title: In vitro efficacy of some cattle drugs on bovine serum paraoxonase 1 (PON1) activity.
abstract: Serum paraoxonase 1 (EC 3.1.8.1, PON1), a calcium-associated enzyme, has an ability to hydrolyze organophosphate compounds. Related to this property, PON1 has a critical role in antioxidant mechanisms. It is well-known that the enzyme protects LDL from oxidation. In this study we investigated the in vitro inhibitory effects of some drugs. These drugs are oxytocin, dexamethasone, atropine sulphate, gentamicin sulphate, sulfadoxine-trimethoprim, furosemid, metamizole sodium and toldimfos sodium. The IC(50) values obtained varied markedly from 0.014 to 507.72 mg/mL. According to our findings, most potent and significant inhibition was displayed by dexamethasone, atropine sulphate and furosemid.
authors: Susurluk Technical Vocational School of Higher Education, Balikesir University, Balikesir, Turkey.
authors: Mikail
authors: M
authors: Arslan
authors: Nahit
authors: N
authors: Gencer
authors: Oktay
authors: O
authors: Arslan
authors: Ozen Ozensoy
authors: OO
authors: Guler
mesh_terms: D000818:Animals; D043303:Aryldialkylphosphatase / Q000037:antagonists & inhibitors* / Q000097:blood; D002417:Cattle; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D066298:In Vitro Techniques; D020128:Inhibitory Concentration 50; D010084:Oxidation-Reduction; D014730:Veterinary Medicine
chemical_list: D004791:Enzyme Inhibitors; D043303:Aryldialkylphosphatase