title: A new sesquiterpenoid from the rhizomes of Homalomena sagittifolia.
abstract: A new sesquiterpenoid, 1α,4β,7β-eudesmanetriol (1), was isolated together with the known compounds 1β,4β,7β-eudesmanetriol (2) and oplopanone (3) from the rhizomes of Homalomena sagittifolia. The structures of these compounds were determined by extensive spectral analyses. The compounds 1 and 2 inhibited growth of Pseudomonas stutzeri with a MIC value of 117 µM when evaluated for antibacterial activity using the minimum concentration assay. Both these compounds showed remarkable activities against acetylcholinesterase enzyme with IC(50) values ranging between 25 and 26 µM. The isolation of these sesquiterpenoids and their biological activities observed in this study support the reported traditional uses of H. sagittifolia for the treatment of microbial related diseases and central nervous system disorders.
authors: School of Chemical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia. kcwong@usm.my
authors: K C
authors: KC
authors: Wong
authors: Abdul
authors: A
authors: Hamid
authors: I M S
authors: IM
authors: Eldeen
authors: M Zaini
authors: MZ
authors: Asmawi
authors: S
authors: S
authors: Baharuddin
authors: H S
authors: HS
authors: Abdillahi
authors: J
authors: J
authors: Van Staden
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology; D029064:Araceae / Q000737:chemistry*; D002800:Cholinesterase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D044223:Pseudomonas stutzeri / Q000187:drug effects; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
chemical_list: D000900:Anti-Bacterial Agents; D002800:Cholinesterase Inhibitors; D012717:Sesquiterpenes