title: Improved blood compatibility of Mg-1.0Zn-1.0Ca alloy by micro-arc oxidation.
abstract: Magnesium and its alloys have been used in the recent development of lightweight, biodegradeable implant materials. However, the corrosion properties of magnesium limit its usefulness. In a previous study, a micro-arc oxidation (MAO) method was used to modify a Mg-1.0 wt % Zn-1.0 wt % Ca alloy surface, with the purpose of improving the corrosion resistance of Mg alloys. However, the blood compatibility of MAO-treated Mg alloy is unknown. Results of cytotoxicity assays with bone marrow-derived mesenchymal stem cells showed that extracts of MAO-treated alloy significantly decreased cytotoxicity compared to titanium alloy extract. Results of blood compatibility tests showed that the MAO group had a decreased hemolytic ratio (2.25%) compared to the untreated Mg alloy group (24.58%) (p < 0.001). The MAO group showed significantly shorter prothrombin and thrombin times and significantly longer activated partial thromboplastin time than the untreated Mg alloy group. Arachidonic acid- and adenosine diphosphate-induced platelet aggregations were significantly decreased by the untreated Mg alloy extract, and they were less affected by extract of MAO-treated Mg alloy. In conclusion, MAO-treated Mg-1.0 wt % Zn-1.0 wt % Ca alloy exhibits favorable blood compatibility characteristics and may be useful in the development of magnesium implant materials.
authors: National Engineering Laboratory for Carbon Fiber Technology, Institute of Coal Chemistry, Chinease Academy of Sciences, Taiyuan 030001, [corrected] People's Republic of China.
authors: Bao-Ping
authors: BP
authors: Zhang
authors: Hui
authors: H
authors: Qiu
authors: Da-Wei
authors: DW
authors: Wang
authors: Yang
authors: Y
authors: Cao
authors: Ying-Qun
authors: YQ
authors: Liu
authors: Zheng-Gang
authors: ZG
authors: Bi
mesh_terms: D000497:Alloys / Q000737:chemistry* / Q000378:metabolism*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism*; D001777:Blood Coagulation; D001854:Bone Marrow Cells / Q000166:cytology / Q000502:physiology; D002118:Calcium / Q000737:chemistry* / Q000378:metabolism; D002478:Cells, Cultured; D002516:Ceramics / Q000737:chemistry; D003343:Corrosion; D006461:Hemolysis; D006801:Humans; D008274:Magnesium / Q000737:chemistry* / Q000378:metabolism; D008297:Male; D008422:Materials Testing; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology; D010084:Oxidation-Reduction; D010974:Platelet Aggregation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013499:Surface Properties
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D008274:Magnesium; D002118:Calcium