title: Intra-arterial chemotherapy for malignant gliomas: a critical analysis.
abstract: Intra-arterial (IA) chemotherapy for malignant gliomas including glioblastoma multiforme was initiated decades ago, with many preclinical and clinical studies having been performed since then. Although novel endovascular devices and techniques such as microcatheter or balloon assistance have been introduced into clinical practice, the question remains whether IA therapy is safe and superior to other drug delivery modalities such as intravenous (IV) or oral treatment regimens. This review focuses on IA delivery and surveys the available literature to assess the advantages and disadvantages of IA chemotherapy for treatment of malignant gliomas. In addition, we introduce our hypothesis of using IA delivery to selectively target cancer stem cells residing in the perivascular stem cell niche.
authors: Department of Neurological Surgery, Weill Cornell Brain Tumor Center, Weill Cornell Medical College, New York, [corrected] USA.
authors: J-K
authors: JK
authors: Burkhardt
authors: H A
authors: HA
authors: Riina
authors: B J
authors: BJ
authors: Shin
authors: J A
authors: JA
authors: Moliterno
authors: C P
authors: CP
authors: Hofstetter
authors: J A
authors: JA
authors: Boockvar
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001812:Blood-Brain Barrier / Q000187:drug effects; D001932:Brain Neoplasms / Q000188:drug therapy*; D016503:Drug Delivery Systems; D005910:Glioma / Q000188:drug therapy*; D006801:Humans; D007261:Infusions, Intra-Arterial
chemical_list: D000970:Antineoplastic Agents