title: Hepatitis C virus infection: molecular pathways to steatosis, insulin resistance and oxidative stress.
abstract: The persistent infection with hepatitis C virus is a major cause of chronic liver disease worldwide. However, the morbidity associated with hepatitis C virus widely varies and depends on several host-related cofactors, such as age, gender, alcohol consumption, body weight, and co-infections. The objective of this review is to discuss three of these cofactors: steatosis, insulin resistance and oxidative stress. Although all may occur independently of HCV, a direct role of HCV infection in their pathogenesis has been reported. This review summarizes the current understanding and potential molecular pathways by which HCV contributes to their development.
authors: Division of Clinical Pathology, University Hospitals, Geneva, Switzerland.
authors: Sophie
authors: S
authors: Clément
authors: Division of Clinical Pathology, University Hospitals, Geneva, Switzerland.
authors: Stéphanie
authors: S
authors: Pascarella
authors: Division of Clinical Pathology, University Hospitals, Geneva, Switzerland.|Division of Gastroenterology and Hepatology, University Hospitals, Geneva, Switzerland.
authors: Francesco
authors: F
authors: Negro