title: A new approach in the first-line treatment of bacterial and mycotic vulvovaginitis with topical lipohydroperoxides and glycyrrhetic acid: a comparative study.
abstract: PURPOSE OF INVESTIGATIONS: The aim of this randomized controlled trial was to evaluate efficacy and tolerability of a new association of lipohydroperoxides and glycyrrhetic acid on topical treatment of bacterial and mycotic vulvovaginitis.
  
  
  METHODS
  One hundred consecutive patients with bacterial or mycotic vulvovaginitis were randomly assigned to a study group treated with vaginal lipohydroperoxides and a derivative of glycyrrhetic acid for three days (n = 50), and a control group using vaginal antibacterial metronidazole (500 mg) or antimycotic econazole (150 mg) for six days (n = 50).
  
  
  RESULTS
  A clinical and microbiological response was achieved in 80.4% and 88.9% in investigational and control group, respectively (p > 0.05). Compared to traditional antimicrobial drugs, the effect appears to be faster and safer, even if not significantly. The 6-month recurrence rate was 7.7% and 5.6% in the investigational and control group, respectively.
  
  
  CONCLUSIONS
  Topical medication based on lipohydroperoxides and glycyrrhetic acid showed a clinical and microbiological efficacy in the first-line treatment of bacterial and mycotic vulvovaginitis, comparable to conventional drugs.
authors: Fondazione IRCCS SDN, Napoli, Italy. giampaolomainini@libero.it
authors: G
authors: G
authors: Mainini
authors: M
authors: M
authors: Rotondi
authors: C
authors: C
authors: Scaffa
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D005260:Female; D006034:Glycyrrhetinic Acid / Q000627:therapeutic use*; D006801:Humans; D008054:Lipid Peroxides / Q000627:therapeutic use*; D008875:Middle Aged; D012008:Recurrence; D013488:Suppositories; D014622:Vaginal Creams, Foams, and Jellies; D014848:Vulvovaginitis / Q000188:drug therapy* / Q000382:microbiology; D055815:Young Adult
chemical_list: D000890:Anti-Infective Agents; D008054:Lipid Peroxides; D013488:Suppositories; D014622:Vaginal Creams, Foams, and Jellies; D006034:Glycyrrhetinic Acid