title: Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.
abstract: Adult height is a classic polygenic trait of high heritability (h(2) approximately 0.8). More than 180 single nucleotide polymorphisms (SNPs), identified mostly in populations of European descent, are associated with height. These variants convey modest effects and explain approximately10% of the variance in height. Discovery efforts in other populations, while limited, have revealed loci for height not previously implicated in individuals of European ancestry. Here, we performed a meta-analysis of genome-wide association (GWA) results for adult height in 20,427 individuals of African ancestry with replication in up to 16,436 African Americans. We found two novel height loci (Xp22-rs12393627, P = 3.4×10(-12) and 2p14-rs4315565, P = 1.2×10(-8)). As a group, height associations discovered in European-ancestry samples replicate in individuals of African ancestry (P = 1.7×10(-4) for overall replication). Fine-mapping of the European height loci in African-ancestry individuals showed an enrichment of SNPs that are associated with expression of nearby genes when compared to the index European height SNPs (P<0.01). Our results highlight the utility of genetic studies in non-European populations to understand the etiology of complex human diseases and traits.
authors: Montreal Heart Institute, Montréal, Canada.
authors: Amidou
authors: A
authors: N'Diaye
authors: Gary K
authors: GK
authors: Chen
authors: Cameron D
authors: CD
authors: Palmer
authors: Bing
authors: B
authors: Ge
authors: Bamidele
authors: B
authors: Tayo
authors: Rasika A
authors: RA
authors: Mathias
authors: Jingzhong
authors: J
authors: Ding
authors: Michael A
authors: MA
authors: Nalls
authors: Adebowale
authors: A
authors: Adeyemo
authors: Véronique
authors: V
authors: Adoue
authors: Christine B
authors: CB
authors: Ambrosone
authors: Larry
authors: L
authors: Atwood
authors: Elisa V
authors: EV
authors: Bandera
authors: Lewis C
authors: LC
authors: Becker
authors: Sonja I
authors: SI
authors: Berndt
authors: Leslie
authors: L
authors: Bernstein
authors: William J
authors: WJ
authors: Blot
authors: Eric
authors: E
authors: Boerwinkle
authors: Angela
authors: A
authors: Britton
authors: Graham
authors: G
authors: Casey
authors: Stephen J
authors: SJ
authors: Chanock
authors: Ellen
authors: E
authors: Demerath
authors: Sandra L
authors: SL
authors: Deming
authors: W Ryan
authors: WR
authors: Diver
authors: Caroline
authors: C
authors: Fox
authors: Tamara B
authors: TB
authors: Harris
authors: Dena G
authors: DG
authors: Hernandez
authors: Jennifer J
authors: JJ
authors: Hu
authors: Sue A
authors: SA
authors: Ingles
authors: Esther M
authors: EM
authors: John
authors: Craig
authors: C
authors: Johnson
authors: Brendan
authors: B
authors: Keating
authors: Rick A
authors: RA
authors: Kittles
authors: Laurence N
authors: LN
authors: Kolonel
authors: Stephen B
authors: SB
authors: Kritchevsky
authors: Loic
authors: L
authors: Le Marchand
authors: Kurt
authors: K
authors: Lohman
authors: Jiankang
authors: J
authors: Liu
authors: Robert C
authors: RC
authors: Millikan
authors: Adam
authors: A
authors: Murphy
authors: Solomon
authors: S
authors: Musani
authors: Christine
authors: C
authors: Neslund-Dudas
authors: Kari E
authors: KE
authors: North
authors: Sarah
authors: S
authors: Nyante
authors: Adesola
authors: A
authors: Ogunniyi
authors: Elaine A
authors: EA
authors: Ostrander
authors: George
authors: G
authors: Papanicolaou
authors: Sanjay
authors: S
authors: Patel
authors: Curtis A
authors: CA
authors: Pettaway
authors: Michael F
authors: MF
authors: Press
authors: Susan
authors: S
authors: Redline
authors: Jorge L
authors: JL
authors: Rodriguez-Gil
authors: Charles
authors: C
authors: Rotimi
authors: Benjamin A
authors: BA
authors: Rybicki
authors: Babatunde
authors: B
authors: Salako
authors: Pamela J
authors: PJ
authors: Schreiner
authors: Lisa B
authors: LB
authors: Signorello
authors: Andrew B
authors: AB
authors: Singleton
authors: Janet L
authors: JL
authors: Stanford
authors: Alex H
authors: AH
authors: Stram
authors: Daniel O
authors: DO
authors: Stram
authors: Sara S
authors: SS
authors: Strom
authors: Bhoom
authors: B
authors: Suktitipat
authors: Michael J
authors: MJ
authors: Thun
authors: John S
authors: JS
authors: Witte
authors: Lisa R
authors: LR
authors: Yanek
authors: Regina G
authors: RG
authors: Ziegler
authors: Wei
authors: W
authors: Zheng
authors: Xiaofeng
authors: X
authors: Zhu
authors: Joseph M
authors: JM
authors: Zmuda
authors: Alan B
authors: AB
authors: Zonderman
authors: Michele K
authors: MK
authors: Evans
authors: Yongmei
authors: Y
authors: Liu
authors: Diane M
authors: DM
authors: Becker
authors: Richard S
authors: RS
authors: Cooper
authors: Tomi
authors: T
authors: Pastinen
authors: Brian E
authors: BE
authors: Henderson
authors: Joel N
authors: JN
authors: Hirschhorn
authors: Guillaume
authors: G
authors: Lettre
authors: Christopher A
authors: CA
authors: Haiman
mesh_terms: D000328:Adult; D001741:Black or African American / Q000235:genetics*; D000368:Aged; D000369:Aged, 80 and over; D001827:Body Height / Q000235:genetics*; D002874:Chromosome Mapping; D005260:Female; D005787:Gene Frequency; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics