title: In vivo flow speed measurement of capillaries by photoacoustic correlation spectroscopy.
abstract: We recently proposed photoacoustic correlation spectroscopy (PACS) and demonstrated a proof-of-concept experiment. Here we use the technique for in vivo flow speed measurement in capillaries in a chick embryo model. The photoacoustic microscopy system is used to render high spatial resolution and high sensitivity, enabling sufficient signals from single red blood cells. The probe beam size is calibrated by a blood-mimicking phantom. The results indicate the feasibility of using PACS to study flow speeds in capillaries.
authors: Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors: Sung-Liang
authors: SL
authors: Chen
authors: Zhixing
authors: Z
authors: Xie
authors: Paul L
authors: PL
authors: Carson
authors: Xueding
authors: X
authors: Wang
authors: L Jay
authors: LJ
authors: Guo
mesh_terms: D000818:Animals; D001775:Blood Circulation / Q000502:physiology*; D001783:Blood Flow Velocity; D002138:Calibration; D002196:Capillaries / Q000502:physiology*; D002642:Chick Embryo; D004912:Erythrocytes / Q000502:physiology; D019047:Phantoms, Imaging; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence / Q000379:methods*