title: Synthesis and in vitro antiproliferative activity of novel (4-chloro- and 4-acyloxy-2-butynyl)thioquinolines.
abstract: The series of new acetylenic thioquinolines containing propargyl, 4-chloro-2-butynyl, and 4-acyloxy-2-butynyl groups have been prepared and tested for antiproliferative activity in vitro against human [SW707 (colorectal adenocarcinoma), CCRF/CEM (leukemia), T47D (breast cancer)] and murine [P388 (leukemia), B16 (melanoma)] cancer lines. Most of the obtained compounds exhibited antiproliferative activity, especially compounds 8, 12, and 21 showed the ID(50) values ranging from 0.4 to 3.8 μg/ml comparable to that of cisplatin used as reference compounds.
authors: Stanisław
authors: S
authors: Boryczka
authors: Wojciech
authors: W
authors: Mól
authors: Magdalena
authors: M
authors: Milczarek
authors: Joanna
authors: J
authors: Wietrzyk
authors: Ewa
authors: E
authors: Bębenek