title: Green synthesis of tetrahydrobenzo[b]Pyrans by microwave assisted multi-component one-pot reactions in PEG-400.
abstract: Polyethylene glycol is found to be a nontoxic and recyclable reaction medium for the microwave-assisted, multi-component one-pot reactions of aromatic aldehydes with ethyl-2-cyanoacetate and 1,3-cyclohexanedione or 5,5- dimethyl-1,3-cyclohexanedione in the presence of piperidine. This environmentally friendly microwave protocol offers ease of operation and enables recyclability of reaction medium and synthesis of a variety of substituted tetrahydrobenzo[b]pyran derivatives. It is an efficient, promising, and green synthetic strategy to construct tetrahydrobenzo[b]pyran skeleton.
authors: School of Chemistry and Chemical Engineering, Hubei University, Wuhan, Hubei, P.R. China.
authors: Chun
authors: C
authors: Feng
authors: Qiuyan
authors: Q
authors: Wang
authors: Cuifen
authors: C
authors: Lu
authors: Guichun
authors: G
authors: Yang
authors: Zuxing
authors: Z
authors: Chen
mesh_terms: D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry; D008872:Microwaves; D015394:Molecular Structure; D011092:Polyethylene Glycols / Q000737:chemistry*
chemical_list: D001578:Benzopyrans; D011092:Polyethylene Glycols