title: Use of antiplatelets. A survey of secondary prevention of ischemic stroke with intracranial hemorrhage history in Chinese patients.
abstract: OBJECTIVE
  To explore whether antiplatelet (AP) agent therapy increased intracranial hemorrhage (ICH) incidence and reduced ischemic stroke recurrence.
  
  
  METHODS
  A single-center retrospective cohort study involving 256 cases from 336 Chinese in-patients who had ischemic stroke with ICH history in Beijing Chaoyang Hospital, Beijing, China between May 2005 and October 2009 was conducted. Subjects were divided into 2 groups (with AP and without AP), followed by stroke events for 12-38 months. Logistic regression analysis was used to evaluate the effects of AP on cerebral infarction and ICH recurrence.
  
  
  RESULTS
  The AP agent did not increase ICH recurrence in the secondary prevention of ischemic stroke with ICH history (odds ratio [OR] 1.431, confidence interval [CI] 0.198-2.467, p=0.577). Hypertension and lobar hemorrhage were risk factors of ICH recurrence. However, there was no statistical difference between recurrence of lobar hemorrhage and AP use (x2=0.516, p=0.468). The AP agent significantly decreased the incidence of cerebral infarction (OR 0.424, CI 0.190-0.950, p=0.037).
  
  
  CONCLUSIONS
  The AP agents may be beneficial to secondary prevention of ischemic stroke with ICH history, with no increased incidence of cerebral hemorrhage. It would be safer to maintain blood pressure in the normal range and to exclude lobar hemorrhage when AP is used.
authors: Department of Neurology, Capital Medical University, Beijing, China.
authors: Weihua
authors: W
authors: Jia
authors: Lichun
authors: L
authors: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D002545:Brain Ischemia / Q000188:drug therapy* / Q000208:ethnology / Q000517:prevention & control*; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D019538:Health Care Surveys / Q000706:statistics & numerical data; D006801:Humans; D020300:Intracranial Hemorrhages / Q000139:chemically induced* / Q000208:ethnology*; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D012189:Retrospective Studies; D055502:Secondary Prevention
chemical_list: D010975:Platelet Aggregation Inhibitors