title: [Micro-invasive vulvar Paget's disease and lymph node metastasis: a same disease?].
abstract: Vulvar Paget's disease is sub-classified into three types based upon its origin. It might be a primary vulvar disease (type 1) or associated with a non-cutaneous adenocarcinoma-rectal, colonic, cervical (type 2) or linked with an urothelial neoplasia (type 3). Type 1lesions must be considered as potentially invasive. Their immunophenotype is CK7+/CK20-. Classically, in case of depth of invasion below 1mm, nodal metastases are exceptional. We report a case of type 1 Paget's disease in a postmenopausal woman with superficial invasion and multiple inguinal nodal metastases.
authors: Service d'anatomie pathologique et d'histologie-cytologie, hôpital de Rangueil, Toulouse, France. quintyn.ml@chu-toulouse.fr
authors: Marie-Laure
authors: ML
authors: Quintyn-Ranty
authors: Ghislaine
authors: G
authors: Escourrou
authors: Amélie
authors: A
authors: Paute
authors: Julie
authors: J
authors: Viale
authors: Céline
authors: C
authors: Guilbeau
authors: Marie-Bernadette
authors: MB
authors: Delisle
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D005625:Frontal Lobe; D006801:Humans; D007633:Keratins / Q000032:analysis; D008207:Lymphatic Metastasis; D008577:Meningeal Neoplasms; D008579:Meningioma; D009361:Neoplasm Invasiveness; D016609:Neoplasms, Second Primary; D010145:Paget Disease, Extramammary / Q000737:chemistry / Q000473:pathology* / Q000556:secondary; D007703:Peptidyl-Dipeptidase A / Q000032:analysis; D017698:Postmenopause; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D014846:Vulvar Neoplasms / Q000737:chemistry / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D007633:Keratins; D007703:Peptidyl-Dipeptidase A; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; C488034:ACE protein, human