title: Effects of hesperidin on the progression of hypercholesterolemia and fatty liver induced by high-cholesterol diet in rats.
abstract: The protective effects of hesperidin against hypercholesterolemia and fatty liver were examined in male Wistar rats fed a high-cholesterol diet for 12 weeks. Compared with a standard diet, a high-cholesterol diet not only increased body weights, liver weights, and serum concentration of cholesterol, but also induced the fatty degeneration (steatosis) of liver. Hesperidin (0.08%) reduced levels of hepatic steatosis, adipose tissue and liver weights (P < 0.05), serum total cholesterol and retinol binding protein (RBP) 4 concentrations (P < 0.05) in rats fed with high-cholesterol diet, while reduction in low-density lipoprotein cholesterol levels and triglyceride concentrations was not significant. It also attenuated the marked changes in mRNA expression of lipid metabolism-related proteins: RBP, heart fatty acid-binding protein (H-FABP), and cutaneous fatty acid-binding protein (C-FABP), in liver and adipose tissue. According to the results of gas chromatography, serum concentrations of total cholesterol and biomarkers of cholesterol synthesis (lathosterol) and absorption (campesterol, β-sitosterol) were lower, and concentrations of cholesterol in feces were higher in the rats given hesperidin (P < 0.05). Hesperidin may improve hypercholesterolemia and fatty liver by inhibiting both the synthesis and absorption of cholesterol and regulating the expression of mRNA for RBP, C-FABP, and H-FABP.
authors: Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University, 86 Nishicho, Yonago 683-8503, Japan.
authors: Xinhui
authors: X
authors: Wang
authors: Junichi
authors: J
authors: Hasegawa
authors: Yoshiyuki
authors: Y
authors: Kitamura
authors: Zhongzhi
authors: Z
authors: Wang
authors: Akiko
authors: A
authors: Matsuda
authors: Waka
authors: W
authors: Shinoda
authors: Norimasa
authors: N
authors: Miura
authors: Koji
authors: K
authors: Kimura
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002791:Cholesterol, Dietary / Q000494:pharmacology; D059305:Diet, High-Fat / Q000009:adverse effects*; D005136:Eye Proteins / Q000378:metabolism; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins / Q000378:metabolism; D005234:Fatty Liver / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D005243:Feces / Q000737:chemistry; D006569:Hesperidin / Q000494:pharmacology / Q000627:therapeutic use*; D006937:Hypercholesterolemia / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D054839:Retinol-Binding Proteins, Plasma / Q000235:genetics / Q000378:metabolism; D013261:Sterols / Q000097:blood; D014280:Triglycerides / Q000097:blood
chemical_list: D000924:Anticholesteremic Agents; D002791:Cholesterol, Dietary; D005136:Eye Proteins; C509948:FABP3 protein, rat; C107356:Fabp5 protein, rat; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins; D009419:Nerve Tissue Proteins; C532035:Rbp4 protein, rat; D054839:Retinol-Binding Proteins, Plasma; D013261:Sterols; D014280:Triglycerides; D006569:Hesperidin