title: Why don't CD8+ T cells reduce the lifespan of SIV-infected cells in vivo?
abstract: In January 2010 two groups independently published the observation that the depletion of CD8+ cells in SIV-infected macaques had no detectable impact on the lifespan of productively infected cells. This unexpected observation led the authors to suggest that CD8+ T cells control SIV viraemia via non-lytic mechanisms. However, a number of alternative plausible explanations, compatible with a lytic model of CD8+ T cell control, were proposed. This left the field with no consensus on how to interpret these experiments and no clear indication whether CD8+ T cells operated primarily via a lytic or a non-lytic mechanism. The aim of this work was to investigate why CD8+ T cells do not appear to reduce the lifespan of SIV-infected cells in vivo.
authors: Department of Immunology, Imperial College London, London, United Kingdom. m.elemans@imperial.ac.uk
authors: Marjet
authors: M
authors: Elemans
authors: Nafisa-Katrin
authors: NK
authors: Seich Al Basatena
authors: Nichole R
authors: NR
authors: Klatt
authors: Christos
authors: C
authors: Gkekas
authors: Guido
authors: G
authors: Silvestri
authors: Becca
authors: B
authors: Asquith
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology* / Q000821:virology*; D002470:Cell Survival; D019295:Computational Biology / Q000379:methods; D008212:Lymphocyte Depletion; D008251:Macaca; D008962:Models, Theoretical; D016097:Simian Acquired Immunodeficiency Syndrome / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000378:metabolism*; D019562:Viral Load; D014766:Viremia / Q000276:immunology / Q000821:virology