title: Concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and polychlorinated biphenyls in blood and breast milk collected from pregnant women in Sapporo City, Japan.
abstract: We measured the concentrations of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), dioxin-like polychlorinated biphenyls (PCBs), and non-dioxin-like PCBs in paired samples of blood and breast milk collected from 67 secundiparas in Sapporo City, Japan, and combined this data with those of the 30 secundiparas previously measured. The arithmetic mean total toxic equivalents (TEQ-WHO) concentrations of PCDDs, PCDFs, non-ortho PCBs, and mono-ortho PCBs in blood and breast milk of the 97 secundiparous subjects were 3.0-23 (mean: 13, median: 14) and 2.7-20 (mean: 8.6, median: 8.5) pg TEQ g(-1) lipid, respectively. The sums of the concentrations of 56 non-dioxin-like PCB congeners that were measured in the subjects' blood and breast milk were 16-326 (mean: 107, median: 100) and 12-252 (mean: 73, median: 67) ng g(-1) lipid, respectively. The partitioning ratios of individual congeners of PCDDs, PCDFs, dioxin-like PCBs, and non-dioxin-like PCBs from blood to breast milk in secundiparas were almost the same as those of primiparas that have been recently reported, suggesting that the partitioning ratios of these compounds from maternal blood to breast milk in women is little affected by delivery. Furthermore, the partition of PCB congeners with chlorine at the 2-, 3-, 4'-, and 5-positions or the 2-, 4-, 4'-, and 5-positions of the biphenyl ring from the blood to the breast milk tended to occur at a higher level than that of other congeners. In particular, the levels of tetraCB-74 and hexaCB-146 in the breast milk for both primiparous and secundiparous mothers were slightly higher than those in the blood.
authors: Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan. todaka@fihes.pref.fukuoka.jp
authors: Takashi
authors: T
authors: Todaka
authors: Hironori
authors: H
authors: Hirakawa
authors: Jumboku
authors: J
authors: Kajiwara
authors: Daisuke
authors: D
authors: Onozuka
authors: Seiko
authors: S
authors: Sasaki
authors: Chihiro
authors: C
authors: Miyashita
authors: Eiji
authors: E
authors: Yoshioka
authors: Motoyuki
authors: M
authors: Yuasa
authors: Reiko
authors: R
authors: Kishi
authors: Takao
authors: T
authors: Iida
authors: Hiroshi
authors: H
authors: Uchi
authors: Masutaka
authors: M
authors: Furue
mesh_terms: D000328:Adult; D001572:Benzofurans / Q000097:blood*; D015331:Cohort Studies; D000072338:Dibenzofurans, Polychlorinated; D005260:Female; D006801:Humans; D007564:Japan; D008895:Milk, Human / Q000737:chemistry*; D011078:Polychlorinated Biphenyls / Q000097:blood*; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000097:blood; D011247:Pregnancy
chemical_list: D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D000072317:Polychlorinated Dibenzodioxins; D011078:Polychlorinated Biphenyls