title: Synthesis and antibacterial activity of a new series of 3-[3-(substituted phenyl)-1-phenyl-1H-pyrazol-5-yl]-2H-chromen-2-one derivatives.
abstract: A series of 3-[3-(substituted phenyl)-1-phenyl-1H-pyrazol-5-yl]-2H-chromen-2-one (4a-k) were synthesized by reaction of 3-[2,3-dibromo-3-(substituted phenyl)propanoyl]-2H-chromen-2-one (3 a-k) with phenyl hydrazine in presence of triethylamine in absolute ethanol, characterized by spectral data and screened for their in vitro antibacterial activity against gram-positive and gram-negative bacteria. Among the series, compounds 4d, 4h and 4i displayed an encouraging antibacterial activity profile as compared to reference standard drug ciprofloxacin against tested bacterial strains.
authors: RVS College of Pharmaceutical Science, Sulur, Coimbatore, Tamilnadu, India. prashant.argade@gmail.com
authors: Prashant
authors: P
authors: Aragade
authors: R Venkat
authors: RV
authors: Narayanan
authors: Veeresh
authors: V
authors: Maddi
authors: Pankaj
authors: P
authors: Patil
authors: Prashant
authors: P
authors: Shinde
authors: Mohan
authors: M
authors: Agrawal
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects* / Q000254:growth & development; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development; D000431:Ethanol / Q000737:chemistry; D005021:Ethylamines / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D010659:Phenylhydrazines / Q000737:chemistry; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000254:growth & development; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D001578:Benzopyrans; D005021:Ethylamines; D010659:Phenylhydrazines; D011720:Pyrazoles; C030299:phenylhydrazine; D000431:Ethanol; D002939:Ciprofloxacin; C016162:triethylamine