title: Antiviral inhibition of enveloped virus release by tetherin/BST-2: action and counteraction.
abstract: Tetherin (BST2/CD317) has been recently recognized as a potent interferon-induced antiviral molecule that inhibits the release of diverse mammalian enveloped virus particles from infected cells. By targeting an immutable structure common to all these viruses, the virion membrane, evasion of this antiviral mechanism has necessitated the development of specific countermeasures that directly inhibit tetherin activity. Here we review our current understanding of the molecular basis of tetherin's mode of action, the viral countermeasures that antagonize it, and how virus/tetherin interactions may affect viral transmission and pathogenicity.
authors: Department of Infectious Disease, King's College London School of Medicine, Guy's Hospital, London SE19RT, UK.
authors: Anna
authors: A
authors: Le Tortorec
authors: Suzanne
authors: S
authors: Willey
authors: Stuart J D
authors: SJ
authors: Neil
mesh_terms: D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism*; D015536:Down-Regulation; D058851:GPI-Linked Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D006678:HIV / Q000235:genetics / Q000502:physiology*; D015658:HIV Infections / Q000235:genetics / Q000378:metabolism* / Q000821:virology; D006801:Humans; D011485:Protein Binding; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism; D057074:Virus Release; D000074010:Bone Marrow Stromal Antigen 2
chemical_list: D015703:Antigens, CD; D058851:GPI-Linked Proteins; D014764:Viral Proteins; C094572:BST2 protein, human; D000074010:Bone Marrow Stromal Antigen 2