title: Synthesis of novel derivatives of esculentoside A and its aglycone phytolaccagenin, and evaluation of their haemolytic activity and inhibition of lipopolysaccharide-induced nitric oxide production.
abstract: A series of 46 compounds derived from esculentoside A and its aglycone were synthesized and characterized. The effect of these compounds on lipopolysaccharide (LPS)-induced NO production, haemolytic activity, and cell viability was evaluated. Structure-activity relationship was established by comparing the derivatives of esculentoside A with its aglycone derivatives. Both the aglycone and its derivatives showed higher inhibitory effects on LPS-induced NO production, and lower haemolytic activities than esculentoside A and its derivatives.
authors: School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, P. R. China.
authors: Wei
authors: W
authors: Gong
authors: Zhihui
authors: Z
authors: Jiang
authors: Peng
authors: P
authors: Sun
authors: Ling
authors: L
authors: Li
authors: Yongsheng
authors: Y
authors: Jin
authors: Lucheng
authors: L
authors: Shao
authors: Wen
authors: W
authors: Zhang
authors: Baoshu
authors: B
authors: Liu
authors: Hongwei
authors: H
authors: Zhang
authors: Hua
authors: H
authors: Tang
authors: Yufeng
authors: Y
authors: Chen
authors: Yanghua
authors: Y
authors: Yi
authors: Dazhi
authors: D
authors: Zhang
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004912:Erythrocytes / Q000187:drug effects; D053878:Hemolytic Agents / Q000737:chemistry* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis*; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D029603:Phytolacca / Q000737:chemistry; D011817:Rabbits; D012503:Saponins / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D053878:Hemolytic Agents; D008070:Lipopolysaccharides; D012503:Saponins; C472597:phytolaccoside B; D009569:Nitric Oxide; C076297:esculentoside A; D009828:Oleanolic Acid