title: Markers of redox imbalance in the blood of hypertensive patients of a community in Northeastern Brazil.
abstract: BACKGROUND
  Recent studies describe the participation of reactive oxygen and nitrogen species in hypertension.
  
  
  OBJECTIVE
  To identify the redox imbalance in the blood of hypertensive.
  
  
  METHODS
  Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH), vitamin C, transferrin, ceruloplasmin, malondialdehyde (MDA) and carbonyl group were quantified in the blood of 20 hypertensives and 21 controls. The individuals had a Body Mass Index of ≥ 18.5 and ≤ 30 kg/m(2), glycemia ≤ 100 mg/dL, serum cholesterol ≤ 200 mg/dL, and were nonsmokers, non-pregnant and non-lactating women, non-users of alopurinol and probucol, with hypertensives on antihypertensive medication. All individuals underwent a preparatory period of 4 weeks without alcohol, vitamin supplements, dexamethasone and paracetamol.
  
  
  RESULTS
  Reduced levels of CAT (p 0.013), GSH (p 0.003) and MDA (p 0.014), and high levels of GPx (p 0.001) and ceruloplasmin (p 0.015) were obtained in the hypertensive group compared with controls. A positive correlation between systolic pressure and MDA in hypertensive and diastolic pressure and CAT in controls was obtained.
  
  
  CONCLUSIONS
  The data obtained suggest that the hypertensives were in redox imbalance, despite the possibly attenuating effect of their antihypertensive medication.
authors: Universidade Federal de Alagoas, Maceió, AL, Brazil. sandra-mary@hotmail.com
authors: Sandra Mary Lima
authors: SM
authors: Vasconcelos
authors: Marília Oliveira Fonseca
authors: MO
authors: Goulart
authors: Maria Alayde Mendonça da
authors: MA
authors: Silva
authors: Vanusa
authors: V
authors: Manfredini
authors: Mara da Silveira
authors: Mda S
authors: Benfato
authors: Luiza Antas
authors: LA
authors: Rabelo
authors: Gilberto
authors: G
authors: Fontes
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000032:analysis* / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D001938:Brazil; D002374:Catalase / Q000097:blood; D004812:Epidemiologic Methods; D005260:Female; D005978:Glutathione / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*
chemical_list: D000959:Antihypertensive Agents; D000975:Antioxidants; D015415:Biomarkers; D008315:Malondialdehyde; D002374:Catalase; D005978:Glutathione