title: Two new imidazolone-containing alkaloids and further metabolites from the ascomycete fungus Tricladium sp.
abstract: Tricladins A and B (1 and 2, resp.), new imidazolone-containing alkaloids, together with five known metabolites, bacillamides A, B (3 and 4, resp.), 20-hydroxyaflavinine (5), N-(2-phenylethyl)acetamide (6), and N(b)-acetyltryptamine (7), have been isolated from the crude extract of the ascomycete fungus Tricladium sp. The structures of 1 and 2 were elucidated primarily by NMR and MS methods. Compound 2 showed marginal cytotoxicity against MDA-MB-231 human breast cancer cells, whereas the known metabolite 4 displayed an inhibitory effect on HIV-1 replication in C8166 cells.
authors: Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, P. R. China.
authors: Xianwei
authors: X
authors: Zou
authors: Shuchun
authors: S
authors: Liu
authors: Zhihui
authors: Z
authors: Zheng
authors: Hua
authors: H
authors: Zhang
authors: Xulin
authors: X
authors: Chen
authors: Xingzhong
authors: X
authors: Liu
authors: Erwei
authors: E
authors: Li
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D005260:Female; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D007093:Imidazoles / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology; D014363:Tryptamines / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D019380:Anti-HIV Agents; D000972:Antineoplastic Agents, Phytogenic; D007093:Imidazoles; D013844:Thiazoles; D014363:Tryptamines; C525339:bacillamide B; C117197:imidazolone; C570498:tricladin A; C570499:tricladin B; C043464:N-acetyltryptamine