title: Circulating CD8+CD56-perforin+ T cells are increased in multiple sclerosis patients.
abstract: Relapsing-remitting multiple sclerosis (RRMS), secondary progressive (SP)MS and primary progressive (PP)MS patients showed higher percentages of circulating CD8+CD56-perforin+ T cells than controls whereas only relapsing RRMS and PPMS patients showed higher perforin expression in CD8+CD56- T cells than controls. MS patients with EDSS ≥3 showed higher percentage of CD8+CD56-perforin+ T cells than patients with EDSS <3 and controls whereas patients with EDSS <3 showed higher percentage of this T cell subpopulation than controls. Our data show that MS is characterized by a dysregulation of CD8+CD56-perforin+ T cells that may play a role in the development of disability.
authors: Institute of Neurology, Department of Neurosciences, Catholic University, Rome, Italy.
authors: Frisullo
authors: F
authors: Giovanni
authors: Plantone
authors: P
authors: Domenico
authors: Marti
authors: M
authors: Alessandro
authors: Iorio
authors: I
authors: Raffaele
authors: Nociti
authors: N
authors: Viviana
authors: Patanella Agata
authors: PA
authors: Katia
authors: Batocchi Anna
authors: BA
authors: Paola
mesh_terms: D000328:Adult; D019002:CD56 Antigen / Q000097:blood; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000473:pathology; D018450:Disease Progression; D018984:Epitopes, T-Lymphocyte / Q000096:biosynthesis / Q000097:blood; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000276:immunology* / Q000473:pathology; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000276:immunology* / Q000473:pathology; D054353:Perforin / Q000096:biosynthesis* / Q000097:blood; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000473:pathology
chemical_list: D019002:CD56 Antigen; D018984:Epitopes, T-Lymphocyte; D054353:Perforin