title: Novel terpenoids from Calocedrus macrolepis var. formosana.
abstract: Calocetriol (1), diacetylcalocediol (2), and ferrugimenthenol (3) were isolated from the bark of Calocedrus macrolepis var. formosana. Among them, 1 and 2 are secoabietane-type diterpenoids, and 3, with a novel C(20)-C(10) skeleton, is classified as a meroterpenoid. The structures of 1-3 were elucidated by spectroscopic analyses, and their biological activities were also evaluated. Compound 3 exhibited significant cytotoxic activity against human oral epidermoid carcinoma KB cells with an IC(50) value of 9.0±0.1 μM.
authors: Department of Chemistry, National Taiwan University, Taipei 106, Taiwan.
authors: Chin-Lin
authors: CL
authors: Hsieh
authors: Mei-Hwei
authors: MH
authors: Tseng
authors: Ryh-Nan
authors: RN
authors: Pan
authors: Jang-Yang
authors: JY
authors: Chang
authors: Ching-Chuan
authors: CC
authors: Kuo
authors: Tzong-Huei
authors: TH
authors: Lee
authors: Yueh-Hsiung
authors: YH
authors: Kuo
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology; D045744:Cell Line, Tumor; D029779:Cupressaceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009062:Mouth Neoplasms / Q000188:drug therapy / Q000473:pathology; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D013729:Terpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D013729:Terpenes