title: Synthesis and pharmacological activity of diterpenylnaphthoquinone derivatives.
abstract: New diterpenylquinones, combining a diterpene diacid and a naphthoquinone, were prepared from junicedric acid and lapachol. The new derivatives were assessed as gastroprotective agents by the HCl-EtOH-induced gastric lesions model in mice as well as for basal cytotoxicity on the following human cell lines: Normal lung fibroblasts (MRC-5), gastric epithelial adenocarcinoma (AGS), and hepatocellular carcinoma (Hep G2). Several of the new compounds were significantly active as antiulcer agents and showed selective cytotoxicity against AGS cells.
authors: Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile.
authors: Mariano Walter
authors: MW
authors: Pertino
authors: Cristina
authors: C
authors: Theoduloz
authors: Jose Antonio
authors: JA
authors: Palenzuela
authors: Maria del Mar
authors: Mdel M
authors: Afonso
authors: Erdem
authors: E
authors: Yesilada
authors: Francisco
authors: F
authors: Monsalve
authors: Paulo
authors: P
authors: González
authors: Daniel
authors: D
authors: Droguett
authors: Guillermo
authors: G
authors: Schmeda-Hirschmann
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D000077743:Diterpene Alkaloids; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D006801:Humans; D008099:Liver / Q000187:drug effects; D008168:Lung / Q000187:drug effects; D008297:Male; D051379:Mice; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013270:Stomach / Q000187:drug effects / Q000473:pathology; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D029663:Tabebuia / Q000737:chemistry
chemical_list: D000897:Anti-Ulcer Agents; D000077743:Diterpene Alkaloids; D004224:Diterpenes; D009285:Naphthoquinones; C555577:diterpene 8(17)-labden-15,19-dioic acid; C008252:lapachol