title: Real-time 3D ultrasound guided interventional system for cardiac stem cell therapy with motion compensation.
abstract: This paper describes a clinically translatable interventional guidance platform to improve the accuracy and precision of stem cell injections into a beating heart. The proposed platform overlays live position of an injection catheter onto a fusion of a pre-procedural MR roadmap with real-time 3D transesophageal echocardiography (TEE). Electromagnetic (EM) tracking is used to initialize the fusion. The fusion is intra-operatively compensated for respiratory motion using a novel algorithm that uses peri-operative full volume ultrasound images. Validation of the system on a moving heart phantom produced a landmark registration accuracy of 2.8 +/- 1.45mm. Validation on animal in vivo data produced an average registration accuracy of 2.2 +/- 1.8 mm; indicating that it is feasible to reliably and robustly fuse the MR road-map with catheter position using 3D ultrasound in a clinical setting.
authors: Philips Research North America, Briarcliff Manor, NY, USA.
authors: Vijay
authors: V
authors: Parthasarathy
authors: Charles
authors: C
authors: Hatt
authors: Zoran
authors: Z
authors: Stankovic
authors: Amish
authors: A
authors: Raval
authors: Ameet
authors: A
authors: Jain
mesh_terms: D000818:Animals; D006348:Cardiac Surgical Procedures / Q000379:methods*; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D019560:Echocardiography, Three-Dimensional / Q000379:methods; D017548:Echocardiography, Transesophageal / Q000379:methods; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D009038:Motion; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012119:Respiration; D033581:Stem Cell Transplantation / Q000379:methods*; D025321:Surgery, Computer-Assisted / Q000379:methods*; D014463:Ultrasonography / Q000379:methods*