title: Differing self-similarity in light scattering spectra: a potential tool for pre-cancer detection.
abstract: The fluctuations in the elastic light scattering spectra of normal and dysplastic human cervical tissues analyzed through wavelet transform based techniques reveal clear signatures of self-similar behavior in the spectral fluctuations. The values of the scaling exponent observed for these tissues indicate the differences in the self-similarity for dysplastic tissues and their normal counterparts. The strong dependence of the elastic light scattering on the size distribution of the scatterers manifests in the angular variation of the scaling exponent. Interestingly, the spectral fluctuations in both these tissues showed multi-fractality (non-stationarity in fluctuations), the degree of multi-fractality being marginally higher in the case of dysplastic tissues. These findings using the multi-resolution analysis capability of the discrete wavelet transform can contribute to the recent surge in the exploration for non-invasive optical tools for pre-cancer detection.
authors: School of Physics, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa.
authors: Sayantan
authors: S
authors: Ghosh
authors: Jalpa
authors: J
authors: Soni
authors: Harsh
authors: H
authors: Purwar
authors: Jaidip
authors: J
authors: Jagtap
authors: Asima
authors: A
authors: Pradhan
authors: Nirmalya
authors: N
authors: Ghosh
authors: Prasanta K
authors: PK
authors: Panigrahi
mesh_terms: D000328:Adult; D000465:Algorithms; D014408:Biomarkers, Tumor / Q000032:analysis*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D005260:Female; D017709:Fractals; D006801:Humans; D008027:Light; D008875:Middle Aged; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000378:metabolism; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D013050:Spectrometry, Fluorescence / Q000379:methods*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor