title: Hollow nanospheres based on the self-assembly of alginate-graft-poly(ethylene glycol) and α-cyclodextrin.
abstract: This article studies the self-assembly of alginate-graft-poly(ethylene glycol) (Alg-g-PEG) and α-cyclodextrin (α-CD) in aqueous solution. It was found that they could form hollow spheres because of the formation of coil-rod Alg-g-PEG/α-CD inclusion complexes. In these Alg-g-PEG/α-CD complexes, the α-CDs are stacked along the PEG side chains to form a rod block, and alginate main chains act as a coil block. More rod-like blocks in Alg-g-PEG/α-CD favor the formation of small assemblies. The assemblies of Alg-g-PEG/α-CD show a dependence on concentration, temperature, pH, and salt concentration. At low concentration (below 0.125%) or high temperature (above 32 °C), Alg-g-PEG/α-CD particles were unstable and disrupted. Increasing the salt or decreasing the pH resulted in the aggregation of Alg-g-mPEG/α-CD particles, as detected by the increase in the recorded hydrodynamic diameter (D(h)).
authors: State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University, Sichuan University, Chengdu 610065, China.
authors: Xian-Wei
authors: XW
authors: Meng
authors: Wei
authors: W
authors: Ha
authors: Cong
authors: C
authors: Cheng
authors: Zhen-Qiang
authors: ZQ
authors: Dong
authors: Li-Sheng
authors: LS
authors: Ding
authors: Bang-Jing
authors: BJ
authors: Li
authors: Sheng
authors: S
authors: Zhang
mesh_terms: D000464:Alginates / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D015394:Molecular Structure; D054118:Nanospheres / Q000737:chemistry*; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*; D016062:Porosity; D013499:Surface Properties; D047391:alpha-Cyclodextrins / Q000737:chemistry*
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D047391:alpha-Cyclodextrins; D011092:Polyethylene Glycols; D020723:Glucuronic Acid; C032613:alpha-cyclodextrin