title: Emerging therapeutic strategies to enhance HDL function.
abstract: Epidemiologic studies indicate a strong inverse correlation between plasma levels of high-density lipoproteins (HDL) and cardiovascular disease (CVD). The most relevant cardioprotective mechanism mediated by HDL is thought to be reverse cholesterol transport (RCT). New insights in HDL biology and RCT have allowed the development of promising agents aimed to increase HDL function and promote atherosclerosis regression. In this regard, apo-AI analogs and CETP inhibitors dalcetrapib and anacetrapib have aroused a great interest and opened new expectations in the treatment of CVD.
authors: Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, Spain. santiredondo@hotmail.com
authors: Santiago
authors: S
authors: Redondo
authors: José
authors: J
authors: Martínez-González
authors: Concha
authors: C
authors: Urraca
authors: Teresa
authors: T
authors: Tejerina
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology / Q000627:therapeutic use; D016632:Apolipoprotein A-I / Q000235:genetics / Q000378:metabolism / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000097:blood* / Q000188:drug therapy* / Q000378:metabolism / Q000517:prevention & control; D002784:Cholesterol / Q000378:metabolism; D053480:Cholesterol Ester Transfer Proteins / Q000037:antagonists & inhibitors; D015507:Drugs, Investigational / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood* / Q000378:metabolism; D000071518:Liver X Receptors; D058990:Molecular Targeted Therapy; D057093:Orphan Nuclear Receptors / Q000819:agonists / Q000627:therapeutic use; D058226:Plaque, Atherosclerotic / Q000097:blood / Q000188:drug therapy / Q000517:prevention & control; D051122:Scavenger Receptors, Class B / Q000037:antagonists & inhibitors
chemical_list: D000924:Anticholesteremic Agents; D016632:Apolipoprotein A-I; D053480:Cholesterol Ester Transfer Proteins; D015507:Drugs, Investigational; D008075:Lipoproteins, HDL; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; C495124:SCARB1 protein, human; D051122:Scavenger Receptors, Class B; C080631:apolipoprotein A-I Milano; D002784:Cholesterol