title: Novel 1-indanone Thiosemicarbazone Antiviral Candidates: Aqueous Solubilization and Physical Stabilization by Means of Cyclodextrins.
abstract: OBJECTIVE
  To investigate cyclodextrin-mediated solubilization and physical stabilization of novel 1-indanone thiosemicarbazone (TSC) candidate drugs that display extremely high self-aggregation and precipitation tendency in water.
  
  
  METHODS
  TSC/CD complexes were produced by co-solvent method, and TSC/CD phase-solubility diagrams were obtained by plotting TSC concentration as a function of increasing CD concentration. Size, size distribution, and zeta-potential of the different TSC/CD complexes and aggregates were fully characterized by dynamic light scattering. The morphology of the structures was visualized by atomic force microscopy.
  
  
  RESULTS
  Results indicated the formation of Type A inclusion complexes; the solubility of different TSCs was enhanced up to 215 times. The study of physical stability revealed that, as opposed to free TSCs that self-aggregate, crystallize, and precipitate in water very rapidly, complexed TSCs remain in solution for at least 1 week. On the other hand, a gradual size growth was observed. This phenomenon stemmed from the self-aggregation of the TSC/CD complex.
  
  
  CONCLUSIONS
  1-indanone TSC/CD inclusion complexes improved aqueous solubility and physical stability of these new drug candidates and constitute a promising technological approach towards evaluation of their activity against the viruses hepatitis B and C.
authors: The Group of Biomaterials & Nanotechnology for Improved Medicines (BIONIMED) Department of Pharmaceutical Technology Faculty of Pharmacy & Biochemistry, University of Buenos Aires, 956 Junín St., 6th Floor, Buenos Aires, CP1113, Argentina.|National Science Research Council (CONICET), Buenos Aires, Argentina.
authors: Romina J
authors: RJ
authors: Glisoni
authors: The Group of Biomaterials & Nanotechnology for Improved Medicines (BIONIMED) Department of Pharmaceutical Technology Faculty of Pharmacy & Biochemistry, University of Buenos Aires, 956 Junín St., 6th Floor, Buenos Aires, CP1113, Argentina.|National Science Research Council (CONICET), Buenos Aires, Argentina.
authors: Diego A
authors: DA
authors: Chiappetta
authors: National Science Research Council (CONICET), Buenos Aires, Argentina.|Department of Pharmacology, Faculty of Pharmacy & Biochemistry University of Buenos Aires, Buenos Aires, Argentina.
authors: Albertina G
authors: AG
authors: Moglioni
authors: The Group of Biomaterials & Nanotechnology for Improved Medicines (BIONIMED) Department of Pharmaceutical Technology Faculty of Pharmacy & Biochemistry, University of Buenos Aires, 956 Junín St., 6th Floor, Buenos Aires, CP1113, Argentina. alesosnik@gmail.com.|National Science Research Council (CONICET), Buenos Aires, Argentina. alesosnik@gmail.com.
authors: Alejandro
authors: A
authors: Sosnik