title: Otolaryngologic manifestations of antineutrophil cytoplasmic antibody-associated vasculitis.
abstract: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is characterized by systemic necrotizing vasculitis, and patients fall into 2 groups: those with proteinase 3-ANCA and those with myeloperoxidase-ANCA. As infections are a trigger of ANCA-associated vasculitis, this disease tends to localize in areas around the upper airway. In this study, the authors compared ear and nasal symptoms between patients with proteinase 3-ANCA and those with myeloperoxidase-ANCA. We undertook a retrospective case series study of 34 patients diagnosed with ANCA-associated vasculitis. The otologic symptoms were divided into 3 types: chronic otitis media, secretory otitis media, and sensorineural hearing loss. Chronic otitis media was more common in patients with proteinase 3-ANCA (P = .001), whereas secretory otitis media was more frequently found in patients with myeloperoxidase-ANCA (P = .007). Crust formation (P = .001), saddle nose (P = .024), and sinusitis (P = .001) were more common in patients with proteinase 3-ANCA than in those with myeloperoxidase-ANCA. Marked differences were observed in the disease spectrum between the 2 ANCA groups.
authors: Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan. nmaru@med.hokudai.ac.jp
authors: Yuji
authors: Y
authors: Nakamaru
authors: Dai
authors: D
authors: Takagi
authors: Nobuhiko
authors: N
authors: Oridate
authors: Akihiro
authors: A
authors: Homma
authors: Satoshi
authors: S
authors: Fukuda
mesh_terms: D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000150:complications* / Q000276:immunology / Q000378:metabolism; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology / Q000378:metabolism; D002908:Chronic Disease; D018450:Disease Progression; D005500:Follow-Up Studies; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D006801:Humans; D053146:Myeloblastin / Q000276:immunology / Q000378:metabolism; D010033:Otitis Media / Q000209:etiology* / Q000276:immunology / Q000378:metabolism; D009195:Peroxidase / Q000276:immunology / Q000378:metabolism; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D009195:Peroxidase; D053146:Myeloblastin