title: Fluoride excess in coccidioidomycosis patients receiving long-term antifungal therapy: an assessment of currently available triazoles.
abstract: The use of voriconazole, a trifluorinated antifungal, has been associated with the development of fluoride excess and periostitis/exostoses. We evaluated a cohort of patients on long-term triazole therapy and found that other fluorinated triazoles (fluconazole and posaconazole) conferred no risk for the development of hyperfluorosis and its complications in our cohort.
authors: Department of Medical Microbiology and Immunology, Coccidioidomycosis Serology Laboratory, University of California—Davis, Davis, California, USA. grthompson@ucdavis.edu
authors: George R
authors: GR
authors: Thompson
authors: Derek
authors: D
authors: Bays
authors: Stuart H
authors: SH
authors: Cohen
authors: Demosthenes
authors: D
authors: Pappagianis
mesh_terms: D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003045:Coccidioides / Q000187:drug effects / Q000254:growth & development; D003047:Coccidioidomycosis / Q000188:drug therapy* / Q000382:microbiology; D015331:Cohort Studies; D005096:Exostoses / Q000139:chemically induced; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage*; D005459:Fluorides / Q000378:metabolism; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010522:Periostitis / Q000139:chemically induced; D011743:Pyrimidines / Q000008:administration & dosage / Q000009:adverse effects*; D014230:Triazoles / Q000008:administration & dosage* / Q000009:adverse effects*; D014481:United States; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; C101425:posaconazole; D015725:Fluconazole; D065819:Voriconazole; D005459:Fluorides