title: Montelukast ameliorates kidney function and urinary bladder sensitivity in experimentally induced renal dysfunction in rats.
abstract: Effect of montelukast on the renal dysfunction induced by cisplatin was investigated. A single dose of cisplatin (7 mg/kg, i.p.) induced nephrotoxicity, which was manifested by increasing the sensitivity of isolated urinary bladder rings to acetylcholine (ACh) together with a significant elevation of serum creatinine, blood urea nitrogen, and lactate dehydrogenase. On the other hand, serum albumin was significantly decreased. Moreover, renal dysfunction was further confirmed by a significant increase in lipid peroxides that were measured as malondialdehyde (MDA) in kidney tissue homogenate. Kidney reduced glutathione (GSH) content and superoxide dismutase (SOD) activity were measured, which were decreased and increased, respectively. Administration of montelukast (10 mg/kg/day, p.o.) 5 days before and 5 days after cisplatin injection significantly ameliorated the renotoxic effects of cisplatin, as judged by a significant reduction in the responses of isolated bladder rings to ACh. The deleterious changes induced by cisplatin treatment in kidney function parameters and oxidative stress markers were significantly mitigated by montelukast treatment.
  
  
  CONCLUSIONS
  Montelukast may be a beneficial remedy for cisplatin-induced renal dysfunction.
authors: Faculty of Pharmacy, Department of Pharmacology and Toxicology, Mansoura University, 35516 Mansoura, Egypt.
authors: Ghada M
authors: GM
authors: Suddek
mesh_terms: D000085:Acetates / Q000494:pharmacology*; D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity; D000975:Antioxidants / Q000378:metabolism; D001806:Blood Urea Nitrogen; D002945:Cisplatin / Q000633:toxicity; D003404:Creatinine / Q000097:blood; D003521:Cyclopropanes; D005978:Glutathione / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D011804:Quinolines / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D051437:Renal Insufficiency / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism; D013440:Sulfides; D013482:Superoxide Dismutase / Q000378:metabolism; D001743:Urinary Bladder / Q000187:drug effects* / Q000378:metabolism
chemical_list: D000085:Acetates; D000970:Antineoplastic Agents; D000975:Antioxidants; D003521:Cyclopropanes; D008054:Lipid Peroxides; D011804:Quinolines; D012709:Serum Albumin; D013440:Sulfides; D008315:Malondialdehyde; D003404:Creatinine; D007770:L-Lactate Dehydrogenase; D013482:Superoxide Dismutase; D005978:Glutathione; C093875:montelukast; D000109:Acetylcholine; D002945:Cisplatin