title: Synthesis of purine modified 2'-C-methyl nucleosides as potential anti-HCV agents.
abstract: Based on the anti-hepatitis C activity of 2'-C-methyl-adenosine and 2'-C-methyl-guanosine, a series of new modified purine 2'-C-methyl nucleosides was prepared as potential anti-hepatitis C virus agents. Herein, we report the synthesis of both 6-modified and 2-modified purine 2'-C-methyl-nucleosides along with their anti-HCV replication activity and cytotoxicity in different cells.
authors: Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors: Hong-wang
authors: HW
authors: Zhang
authors: Longhu
authors: L
authors: Zhou
authors: Steven J
authors: SJ
authors: Coats
authors: Tamara R
authors: TR
authors: McBrayer
authors: Phillip M
authors: PM
authors: Tharnish
authors: Lavanya
authors: L
authors: Bondada
authors: Mervi
authors: M
authors: Detorio
authors: Sarah A
authors: SA
authors: Amichai
authors: Melissa D
authors: MD
authors: Johns
authors: Tony
authors: T
authors: Whitaker
authors: Raymond F
authors: RF
authors: Schinazi
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D016174:Hepacivirus / Q000187:drug effects*; D006526:Hepatitis C / Q000188:drug therapy; D006801:Humans; D011684:Purine Nucleosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D011684:Purine Nucleosides