title: High fat diet induced downregulation of microRNA-467b increased lipoprotein lipase in hepatic steatosis.
abstract: Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic fat accumulation and is presently the most common chronic liver disease. However, the mechanisms underlying the development of steatosis remain unclear. MicroRNAs (miRNAs) are small non-coding RNAs that modulate a variety of biological functions. We have investigated the role of miRNA in the development of steatosis. We found that miR-467b expression is significantly downregulated in liver tissues of high-fat diet fed mice and in steatosis-induced hepatocytes. The downregulation of miR-467b resulted in the upregulation of hepatic lipoprotein lipase (LPL), the direct target of miR-467b. Moreover, the interaction between miR-467b and LPL was associated with insulin resistance, a major cause of NAFLD. These results suggest that downregulation of miR-467b is involved in the development of hepatic steatosis by modulating the expression of its target, LPL.
authors: Functional Food Research Center, Research Division for Emerging Innovative Technology, Korea Food Research Institute, Seoungnam-si, Gyeonggi-do 463-746, South Korea.
authors: Jiyun
authors: J
authors: Ahn
authors: Hyunjung
authors: H
authors: Lee
authors: Chang Hwa
authors: CH
authors: Chung
authors: Taeyoul
authors: T
authors: Ha
mesh_terms: D000818:Animals; D059305:Diet, High-Fat / Q000009:adverse effects*; D015536:Down-Regulation; D005234:Fatty Liver / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D008071:Lipoprotein Lipase / Q000037:antagonists & inhibitors* / Q000235:genetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*
chemical_list: C569061:MIRN467 microRNA, mouse; D035683:MicroRNAs; D008071:Lipoprotein Lipase