title: Antiplasmodial and antiproliferative pseudoguaianolides of Athroisma proteiforme from the Madagascar Dry Forest.
abstract: Investigation of extracts from the plant Athroisma proteiforme (Humbert) Mattf. (Asteraceae) for antimalarial activity led to the isolation of the five new sesquiterpene lactones 1-5 together with centaureidin (6). The structures of the new compounds were deduced from analyses of physical and spectroscopic data, and the absolute configuration of compound 1 was confirmed by an X-ray crystallographic study. Athrolides C (3) and D (4) both showed antiplasmodial activities with IC50 values of 6.6 (3) and 7.2 μM (4) against the HB3 strain and 5.5 (3) and 4.2 μM (4) against the Dd2 strain of the malarial parasite Plasmodium falciparum. The isolates 1-6 also showed antiproliferative activity against A2780 human ovarian cancer cells, with IC50 values ranging from 0.4 to 2.5 μM.
authors: Department of Chemistry, M/C 0212, Virginia Tech, Blacksburg, Virginia 24061, United States.
authors: Ende
authors: E
authors: Pan
authors: Alexander P
authors: AP
authors: Gorka
authors: John N
authors: JN
authors: Alumasa
authors: Carla
authors: C
authors: Slebodnick
authors: Liva
authors: L
authors: Harinantenaina
authors: Peggy J
authors: PJ
authors: Brodie
authors: Paul D
authors: PD
authors: Roepe
authors: Richard
authors: R
authors: Randrianaivo
authors: Chris
authors: C
authors: Birkinshaw
authors: David G I
authors: DG
authors: Kingston
mesh_terms: D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008270:Madagascar; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014197:Trees
chemical_list: D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D007783:Lactones; D012717:Sesquiterpenes; C569056:athrolide C; C569057:athrolide D; C083161:centaureidin