title: Association of hyperplastic polyposis syndrome, colorectal cancer and meningioma.
abstract: Recent research has provided compelling evidence that a subset of hyperplastic polyps may be associated with a risk of colorectal cancer. Colorectal cancer with extracolonic manifestation is usually seen in a hereditary syndrome setting, but some association with meningioma has been reported. The association of colorectal cancer with hyperplastic polyposis and meningioma is extremely rare. This report in a 57-year-old female with no family history of colon cancer or polyps, could be the first case of hyperplastic polyposis syndrome, colorectal cancer and meningioma. Hyperplastic polyposis syndrome was diagnosed as per WHO criteria at the time of colon cancer diagnosis. Within 4 months of colon cancer diagnosis she developed seizures. Imaging of the brain revealed meningioma of the left cerebellopontine angle. The patient underwent surgery followed by chemotherapy.
authors: Department of Internal Medicine, Department of Pathology, Department of Hematology and Oncology, University of Toledo Medical Center, Ohio 43614, USA. mahvish.muzaffar@utoledo.edu
authors: Mahvish
authors: M
authors: Muzaffar
authors: John
authors: J
authors: Irlam
authors: Iman
authors: I
authors: Mohamed
mesh_terms: D015179:Colorectal Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008279:Magnetic Resonance Imaging; D008579:Meningioma / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008875:Middle Aged; D011127:Polyps / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D013577:Syndrome