title: Supercritical extraction of phloroglucinol and benzophenone derivatives from Hypericum carinatum: quantification and mathematical modeling.
abstract: The aerial parts of Hypericum carinatum (Guttiferae) were extracted with supercritical carbon dioxide under constant temperature (40, 50 or 60°C) and gradual pressure increase (90, 120, 150 and 200 bar) aiming at the recovery of enriched fractions containing uliginosin B, cariphenone A and cariphenone B, compounds of pharmaceutical interest. The yields of these substances were determined by high-performance liquid chromatography and compared with those obtained with n-hexane maceration. The supercritical-fluid extraction showed higher selectivity than the conventional solvent extraction method. After defining 40°C and 90 bar as the best conditions to obtain the target compounds, a mathematical model was used for the extraction process and a good correlation was achieved with the experimental data.
authors: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
authors: Francisco M C
authors: FM
authors: Barros
authors: Flávia C
authors: FC
authors: Silva
authors: Jéssica M
authors: JM
authors: Nunes
authors: Rubem M F
authors: RM
authors: Vargas
authors: Eduardo
authors: E
authors: Cassel
authors: Gilsane L
authors: GL
authors: von Poser
mesh_terms: D001577:Benzophenones / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid; D020902:Hypericum / Q000737:chemistry*; D008956:Models, Chemical; D010696:Phloroglucinol / Q000032:analysis* / Q000302:isolation & purification*; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry*
chemical_list: D001577:Benzophenones; D010936:Plant Extracts; C047723:benzophenone; D010696:Phloroglucinol