title: Protective constituents against sepsis in mice from the root barks of Ulmus davidiana var. japonica.
abstract: In the course of isolating preventive agents against sepsis based on the in vivo assay model, eleven known compounds, (-)-catechin (1), catechin-7-O-β-apiofuranoside (2), catechin-7-O-α-Lrhamnopyranoside (3), catechin-3-O-α-L-rhamnopyranoside (4), catechin-7-O-β-D-glucopyranoside (5), butyl (+)-5'-methoxyisolariciresinol-9'-O-β-D-xylopyranoside (6), lyoniside (7), nudiposide (8), α-nigerose (9), butyl α-D-fructofuranoside (10), and procyanidin B(3) (11) were isolated from the root barks of Ulmus davidiana var. japonica. Compounds 2, 6, and 8 significantly protected against sepsis in a mouse model with survival rates of mice exposed to 10 mg/kg of LPS/D-GalN ranged from 80%-100%. Among them, 8 exhibited the most potent protective effect and decreased the plasma levels of TNF-α, IL-10 and ALT activity.
authors: College of Pharmacy, Yeungnam University, Gyongsan 712-749, Korea.
authors: Ming Shan
authors: MS
authors: Zheng
authors: Gao
authors: G
authors: Li
authors: Ying
authors: Y
authors: Li
authors: Chang-Seob
authors: CS
authors: Seo
authors: Yeun-Kyung
authors: YK
authors: Lee
authors: Jun-Sub
authors: JS
authors: Jung
authors: Dong-Keun
authors: DK
authors: Song
authors: Hong-Beom
authors: HB
authors: Bae
authors: Sang-Hyun
authors: SH
authors: Kwak
authors: Hyun-Wook
authors: HW
authors: Chang
authors: Jae-Ryong
authors: JR
authors: Kim
authors: Jong-Keun
authors: JK
authors: Son
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000627:therapeutic use*; D002851:Chromatography, High Pressure Liquid; D004195:Disease Models, Animal; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use*; D018517:Plant Roots / Q000737:chemistry; D012772:Shock, Septic / Q000276:immunology / Q000517:prevention & control*; D016019:Survival Analysis; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D034403:Ulmus / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D015850:Interleukin-6; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D000410:Alanine Transaminase