title: Insulin resistance increases risk of carpal tunnel syndrome: a case-control study.
abstract: Carpal tunnel syndrome (CTS) is one of the most common upper limb compression neuropathies. In only 50% of cases it is possible to identify a cause. Our objective was to determine the role of glucose metabolism abnormalities in idiopathic CTS. We identified 117 patients with idiopathic moderate or severe CTS and 128 controls. In all we evaluated glucose and insulin levels at fasting and after 2-h oral glucose tolerance test (2h-OGTT). In addition we determined insulin resistance (IR). Following OGTT the prevalence of glucose metabolism abnormalities was significantly higher in the CTS group (p = 0.001). IR was documented in 80% of patients, of whom 45% had impaired glucose tolerance, 14% newly diagnosed diabetes mellitus, and 20% IR only. Waist circumference and body mass index were also significantly increased in the CTS group. In this study, we focused on evidence that pre-diabetes may represent a risk factor for CTS. We proposed to determine IR as a rule in all patients with idiopathic CTS.
authors: Department of Neuroscience, S. Giovanni di Dio Hospital, Crotone, Italy.
authors: Massimiliano
authors: M
authors: Plastino
authors: Antonietta
authors: A
authors: Fava
authors: Colica
authors: C
authors: Carmela
authors: Matteo
authors: M
authors: De Bartolo
authors: Caterina
authors: C
authors: Ermio
authors: Dario
authors: D
authors: Cristiano
authors: Maria
authors: M
authors: Ettore
authors: Ludovico
authors: L
authors: Abenavoli
authors: Domenico
authors: D
authors: Bosco
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002349:Carpal Tunnel Syndrome / Q000150:complications* / Q000453:epidemiology* / Q000378:metabolism; D016022:Case-Control Studies; D004576:Electromyography; D005260:Female; D018149:Glucose Intolerance / Q000150:complications* / Q000453:epidemiology* / Q000378:metabolism; D005951:Glucose Tolerance Test; D006801:Humans; D015994:Incidence; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose