title: Wavelength-orthogonal photolysis of neurotransmitters in vitro.
abstract: Irradiation of a mixture of 4-methoxyphenacyl-caged (S)-glutamate and 4,5-dimethoxy-2-nitrobenzyl-caged γ-amino butyric acid (GABA) on neurons, at ~260 nm, evokes selective photorelease of (S)-glutamate (Glu) whereas photolysis at 405 nm causes selective photorelease of GABA.
authors: Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.
authors: Megan N
authors: MN
authors: Stanton-Humphreys
authors: Ruth D T
authors: RD
authors: Taylor
authors: Craig
authors: C
authors: McDougall
authors: Mike L
authors: ML
authors: Hart
authors: C Tom A
authors: CT
authors: Brown
authors: Nigel J
authors: NJ
authors: Emptage
authors: Stuart J
authors: SJ
authors: Conway
mesh_terms: D000818:Animals; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D018756:GABA Antagonists / Q000494:pharmacology; D005971:Glutamates / Q000378:metabolism; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D009682:Magnetic Resonance Spectroscopy; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D018377:Neurotransmitter Agents / Q000037:antagonists & inhibitors / Q000378:metabolism; D018408:Patch-Clamp Techniques; D010777:Photochemistry / Q000379:methods*; D010782:Photolysis / Q000528:radiation effects; D018079:Receptors, GABA / Q000378:metabolism; D017470:Receptors, Glutamate / Q000378:metabolism; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D014466:Ultraviolet Rays; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D018691:Excitatory Amino Acid Antagonists; D018756:GABA Antagonists; D005971:Glutamates; D018377:Neurotransmitter Agents; D018079:Receptors, GABA; D017470:Receptors, Glutamate; C082764:alpha-(4,5-dimethoxy-2-nitrobenzyl) glutamate; D005680:gamma-Aminobutyric Acid