title: Angiogenic therapy for cardiac repair based on protein delivery systems.
abstract: Cardiovascular diseases remain the first cause of morbidity and mortality in the developed countries and are a major problem not only in the western nations but also in developing countries. Current standard approaches for treating patients with ischemic heart disease include angioplasty or bypass surgery. However, a large number of patients cannot be treated using these procedures. Novel curative approaches under investigation include gene, cell, and protein therapy. This review focuses on potential growth factors for cardiac repair. The role of these growth factors in the angiogenic process and the therapeutic implications are reviewed. Issues including aspects of growth factor delivery are presented in relation to protein stability, dosage, routes, and safety matters. Finally, different approaches for controlled growth factor delivery are discussed as novel protein delivery platforms for cardiac regeneration.
authors: Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain.
authors: F R
authors: FR
authors: Formiga
authors: E
authors: E
authors: Tamayo
authors: T
authors: T
authors: Simón-Yarza
authors: B
authors: B
authors: Pelacho
authors: F
authors: F
authors: Prósper
authors: M J
authors: MJ
authors: Blanco-Prieto
mesh_terms: D043925:Angiogenesis Inducing Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage / Q000627:therapeutic use*; D017202:Myocardial Ischemia / Q000188:drug therapy*; D011506:Proteins
chemical_list: D043925:Angiogenesis Inducing Agents; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins