title: Serum levels of lipids, lipoproteins and paraoxonase activity in pre-eclampsia.
abstract: Serum paraoxonase 1 (PON1) activity and the oxidation of lipoproteins were investigated in 35 women with pre-eclampsia and in 35 healthy control women with normal pregnancies. Blood pressure, body mass index (BMI), serum levels of total cholesterol, triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB) and lipoprotein (a) (Lp[a]), and PON1 activity were assessed. There were no significant between-group differences in subject age, gestational age at diagnosis of pre-eclampsia, BMI, serum total cholesterol, triglycerides, LDL and ApoB levels. Mean systolic and diastolic blood pressures and serum Lp(a) were significantly higher in subjects with pre-eclampsia than in controls. Mean serum HDL, ApoA1 and PON1 activity were significantly lower in subjects with pre-eclampsia compared with controls. In conclusion, lipids and oxidized lipoproteins may play important roles in the pathogenesis of pre-eclampsia.
authors: Department of Obstetrics and Gynaecology, Ergani State Hospital, Diyarbakir, Turkey. bulentdemirmd@hotmail.com
authors: B
authors: B
authors: Demir
authors: S
authors: S
authors: Demir
authors: Y
authors: Y
authors: Atamer
authors: S
authors: S
authors: Guven
authors: A
authors: A
authors: Atamer
authors: Y
authors: Y
authors: Kocyigit
authors: A
authors: A
authors: Hekimoglu
authors: G
authors: G
authors: Toprak
mesh_terms: D000328:Adult; D043303:Aryldialkylphosphatase / Q000097:blood*; D001794:Blood Pressure; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D011225:Pre-Eclampsia / Q000378:metabolism* / Q000473:pathology; D011247:Pregnancy; D011379:Prognosis
chemical_list: D008055:Lipids; D008074:Lipoproteins; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human