title: [T-cell large granular lymphocyte leukemia after autologous peripheral blood stem cell transplantation for malignant lymphoma-report of three cases and a review of the literature].
abstract: There have been only three reports in the literature of T-cell large granular lymphocyte (T-LGL) leukemia occurring after autologous peripheral stem cell transplantation (APBSCT). We describe 3 patients in whom a transient monoclonal T-LGL developed after APBSCT for malignant lymphoma. Case 1: A 58-year-old man with peripheral T-cell lymphoma in second complete remission (CR) who underwent APBSCT. Case 2: A 51-year-old man with follicular lymphoma in second CR who underwent APBSCT. Case 3: A 65-year-old man with diffuse large B-cell lymphoma in second CR who underwent tandem APBSCT. One month after transplant, fever followed by the proliferation of CD8+/CD57+ T-LGL in peripheral blood occurred in all three cases. Because clonal rearrangements of the T-cell receptor were detected in peripheral blood samples, T-LGL leukemia was diagnosed. The first patient had episodes of Epstein-Barr virus viremia. The other patients suffered from cytomegalovirus colitis after APBSCT. These data show that T-LGL leukemia can occur after viral infection followed by APBSCT.
authors: Department of Gastroenterology and Hematology/Clinical Oncology, Internal Medicine, Steel Memorial Muroran Hospital, Japan.
authors: Hiroyuki
authors: H
authors: Kuroda
authors: Tamaki
authors: T
authors: Sakurai
authors: Michiko
authors: M
authors: Yamada
authors: Tomoyuki
authors: T
authors: Abe
authors: Shigeyuki
authors: S
authors: Fujii
authors: Masahiro
authors: M
authors: Maeda
authors: Kyuhei
authors: K
authors: Kohda
authors: Yasuo
authors: Y
authors: Hirayama
authors: Wataru
authors: W
authors: Jyomen
authors: Naoki
authors: N
authors: Uemura
authors: Michihiro
authors: M
authors: Ono
authors: Yuko
authors: Y
authors: Fujimi
authors: Satoshi
authors: S
authors: Iyama
authors: Tsutomu
authors: T
authors: Sato
authors: Junji
authors: J
authors: Kato
mesh_terms: D000368:Aged; D003587:Cytomegalovirus / Q000502:physiology; D004854:Herpesvirus 4, Human / Q000502:physiology; D006801:Humans; D054066:Leukemia, Large Granular Lymphocytic / Q000473:pathology* / Q000821:virology; D008223:Lymphoma / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000473:pathology* / Q000821:virology; D036102:Peripheral Blood Stem Cell Transplantation; D014182:Transplantation, Autologous