title: Metabolic syndrome is associated with change in subclinical arterial stiffness: a community-based Taichung community health study.
abstract: BACKGROUND
  The aim of this study was to evaluate the effect of MetS on arterial stiffness in a longitudinal study.
  
  
  METHODS
  Brachial-ankle pulse wave velocity (baPWV), a measurement interpreted as arterial stiffness, was measured in 1518 community-dwelling persons at baseline and re-examined within a mean follow-up period of 3 years. Multivariate linear regression with generalized estimating equations (GEE) were used to examine the longitudinal relationship between MetS and its individual components and baPWV, while multivariate logistic regression with GEE was used to examine the longitudinal relationship between MetS and its individual components and the high risk group with arterial stiffness.
  
  
  RESULTS
  Subjects with MetS showed significantly greater baPWV at the end point than those without MetS, after adjusting for age, gender, education, hypertension medication and mean arterial pressure (MAP). MetS was associated with the top quartile of baPWV (the high-risk group of arterial stiffness, adjusted odds ratio [95% confidence interval] 1.52 [1.21-1.90]), and a significant linear trend of risk for the number of components of MetS was found (p for trend < 0.05). In further considering the individual MetS component, elevated blood pressure and fasting glucose significantly predicted a high risk of arterial stiffness (adjusted OR [95% CI] 3.72 [2.81-4.93] and 1.35 [1.08-1.68], respectively).
  
  
  CONCLUSIONS
  MetS affects the subject's progression to arterial stiffness. Arterial stiffness increased as the number of MetS components increased. Management of MetS is important for preventing the progression to advanced arterial stiffness.
authors: School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
authors: Chia-Ing
authors: CI
authors: Li
authors: Sharon Lr
authors: SL
authors: Kardia
authors: Chiu-Shong
authors: CS
authors: Liu
authors: Wen-Yuan
authors: WY
authors: Lin
authors: Chih-Hsueh
authors: CH
authors: Lin
authors: Yi-Dar
authors: YD
authors: Lee
authors: Fung-Chang
authors: FC
authors: Sung
authors: Tsai-Chung
authors: TC
authors: Li
authors: Cheng-Chieh
authors: CC
authors: Lin
mesh_terms: D000328:Adult; D000368:Aged; D055109:Ankle Brachial Index; D000886:Anthropometry; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications*; D008875:Middle Aged; D016017:Odds Ratio; D013624:Taiwan; D059289:Vascular Stiffness / Q000502:physiology*