title: The emergence of rotavirus G12 and the prevalence of enteric viruses in hospitalized pediatric diarrheal patients in southern Vietnam.
abstract: Diarrhea is a major cause of childhood morbidity and mortality in developing countries, and the majority of infections are of viral etiology. We aimed to compare the etiological prevalence of the major enteric viruses in an urban and a rural setting in southern Vietnam. We simultaneously screened fecal specimens from 362 children in Ho Chi Minh City and Dong Thap province that were hospitalized with acute diarrhea over a 1-month-long period for four viral gastrointestinal pathogens. Rotavirus was the most common pathogen identified, but there was a differential prevalence of rotavirus and norovirus between the urban and rural locations. Furthermore, rotavirus genotyping and phylogenetic analysis again differentiated the genotypes by the sampling location. Our data show a disproportional distribution of enteric viral pathogens in urban and rural locations, and we provide evidence of continual importation of new rotavirus strains into southern Vietnam and report the emergence of rotavirus genotype G12.
authors: Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam. mypvt@oucru.org
authors: Phan Vu
authors: PV
authors: Tra My
authors: Maia A
authors: MA
authors: Rabaa
authors: Ha
authors: H
authors: Vinh
authors: Edward C
authors: EC
authors: Holmes
authors: Nguyen Van Minh
authors: NV
authors: Hoang
authors: Nguyen Thanh
authors: NT
authors: Vinh
authors: Le Thi
authors: le T
authors: Phuong
authors: Nguyen Thi
authors: NT
authors: Tham
authors: Phan Van Be
authors: PV
authors: Bay
authors: James I
authors: JI
authors: Campbell
authors: Jeremy
authors: J
authors: Farrar
authors: Stephen
authors: S
authors: Baker
mesh_terms: D002648:Child; D003967:Diarrhea / Q000628:therapy / Q000821:virology*; D004770:Enterovirus / Q000235:genetics / Q000254:growth & development / Q000302:isolation & purification*; D005838:Genotype; D006760:Hospitalization; D006801:Humans; D010802:Phylogeny; D015995:Prevalence; D012401:Rotavirus / Q000235:genetics / Q000254:growth & development / Q000302:isolation & purification*; D014744:Vietnam / Q000453:epidemiology