title: Novel platinum(II) and palladium(II) complexes of thiosemicarbazones derived from 5-substitutedthiophene-2-carboxaldehydes and their antiviral and cytotoxic activities.
abstract: A series of thiosemicarbazones and their platinum(II) and palladium(II) complexes have been synthesized. The chemical structures of ligands and their complexes were characterized by UV-Vis, IR, (1)H NMR, (13)C NMR, MS spectra, elemental analysis and TGA. The antiviral and cytotoxic activities of all compounds have been tested. Results of broad antiviral evaluation showed that none of the compounds evaluated endowed with anti-DNA or -RNA virus activity at subtoxic concentrations except for the palladium complex 1b. This compound exhibited slightly selective inhibition against cytomegalovirus. The platinum complex 4a exhibited the best cytostatic activities against human cervix carcinoma. Ligands 2, 4 and 5 showed cytostatic potential. The palladium complexes were in general less cytostatic than the corresponding platinum complexes or unliganded congeners.
authors: Department of Chemistry, Faculty of Arts and Sciences, Gaziantep University, 27310 Gaziantep, Turkey.
authors: Ayşegül
authors: A
authors: Karaküçük-İyidoğan
authors: Demet
authors: D
authors: Taşdemir
authors: Emine Elçin
authors: EE
authors: Oruç-Emre
authors: Jan
authors: J
authors: Balzarini
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D015195:Drug Design; D006801:Humans; D013058:Mass Spectrometry; D009944:Organoplatinum Compounds / Q000737:chemistry* / Q000494:pharmacology*; D010165:Palladium / Q000737:chemistry*; D013057:Spectrum Analysis; D013696:Temperature; D013882:Thiosemicarbazones / Q000737:chemistry*; D014780:Viruses / Q000187:drug effects
chemical_list: D000447:Aldehydes; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D009944:Organoplatinum Compounds; D013882:Thiosemicarbazones; D010165:Palladium