title: Chemical stability and antimicrobial activity of plasma sprayed bioactive Ca2ZnSi2O7 coating.
abstract: Calcium silicate ceramic coatings have received considerable attention in recent years due to their excellent bioactivity and bonding strength. However, their high dissolution rates limit their practical applications. In this study, zinc incorporated calcium silicate based ceramic Ca(2)ZnSi(2)O(7) coating was prepared on Ti-6Al-4V substrate via plasma spraying technology aiming to achieve higher chemical stability and additional antibacterial activity. Chemical stability of the coating was assessed by monitoring mass loss and ion release of the coating after immersion in the Tris-HCl buffer solution and examining pH value variation of the solution. Results showed that the chemical stability of zinc incorporated coating was improved significantly. Antimicrobial activity of the Ca(2)ZnSi(2)O(7) coating was evaluated, and it was found that the coating exhibited 93% antibacterial ratio against Staphylococcus aureus. In addition, in vitro bioactivity and cytocompatibility were confirmed for the Ca(2)ZnSi(2)O(7) coating by simulated body fluid test, MC3T3-E1 cells adhesion investigation and cytotoxicity assay.
authors: Key Laboratory of Inorganic Coating Materials, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, People's Republic of China.
authors: Kai
authors: K
authors: Li
authors: Jiangming
authors: J
authors: Yu
authors: Youtao
authors: Y
authors: Xie
authors: Liping
authors: L
authors: Huang
authors: Xiaojian
authors: X
authors: Ye
authors: Xuebin
authors: X
authors: Zheng
mesh_terms: D016475:3T3 Cells; D000497:Alloys; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001826:Body Fluids; D002118:Calcium / Q000737:chemistry*; D002448:Cell Adhesion; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007477:Ions; D051379:Mice; D008855:Microscopy, Electron, Scanning; D010100:Oxygen / Q000737:chemistry*; D011208:Powders; D011312:Pressure; D012825:Silicon / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects; D013234:Stem Cells; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry
chemical_list: D000497:Alloys; D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D007477:Ions; D011208:Powders; C031462:titanium alloy (TiAl6V4); D014025:Titanium; D015032:Zinc; D010100:Oxygen; D002118:Calcium; D012825:Silicon