title: [Exposure to nanoparticle-rich diesel exhaust may cause liver damage].
abstract: Diesel exhaust (DE) is one of the air pollutants in the world, and exposure to DE is an environmental health concern. Most studies amongst the limited number of studies on hepatotoxicity have focused on genotoxicity or mutagenicity. However, DE exposure may cause liver damage because one prospective study suggests that DE exposure is associated with increased mortality due to arteriosclerosis and cirrhosis of the liver. Peroxisome proliferator-activated receptor (PPAR) α plays a role in the regulation of lipid homeostasis and inflammation and thereby may be involved in the progression of atherosclerosis. We investigated whether nanoparticle-rich diesel exhaust (NR-DE) affects the liver and how PPARα is involved in the NR-DE induced effects. We report these results briefly in this minireview. Our results suggest NR-DE-induced hepatic inflammation and dyslipidemia. PPARα may be involved in the development of these disorders.
authors: Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medical Sciences, Japan.
authors: Yuki
authors: Y
authors: Ito
authors: Doni Hikmat
authors: DH
authors: Ramdhan
authors: Yukie
authors: Y
authors: Yanagiba
authors: Nozomi
authors: N
authors: Yamagishi
authors: Michihiro
authors: M
authors: Kamijima
authors: Tamie
authors: T
authors: Nakajima
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D001161:Arteriosclerosis / Q000139:chemically induced; D006801:Humans; D008099:Liver / Q000187:drug effects*; D053758:Nanoparticles / Q000633:toxicity*; D047492:Peroxisome Proliferator-Activated Receptors; D001335:Vehicle Emissions / Q000633:toxicity*
chemical_list: D000393:Air Pollutants; D047492:Peroxisome Proliferator-Activated Receptors; D001335:Vehicle Emissions