title: Myocardial segmentation of late gadolinium enhanced MR images by propagation of contours from cine MR images.
abstract: Automatic segmentation of myocardium in Late Gadolinium Enhanced (LGE) Cardiac MR (CMR) images is often difficult due to the intensity heterogeneity resulting from accumulation of contrast agent in infarcted areas. In this paper, we propose an automatic segmentation framework that fully utilizes shared information between corresponding cine and LGE images of a same patient. Given myocardial contours in cine CMR images, the proposed framework achieves accurate segmentation of LGE CMR images in a coarse-to-fine manner. Affine registration is first performed between the corresponding cine and LGE image pair, followed by nonrigid registration, and finally local deformation of myocardial contours driven by forces derived from local features of the LGE image. Experimental results on real patient data with expert outlined ground truth show that the proposed framework can generate accurate and reliable results for myocardial segmentation of LGE CMR images.
authors: Department of Electrical and Computer Engineering, National University of Singapore, Singapore. dongwei@nus.edu.sg
authors: Dong
authors: D
authors: Wei
authors: Ying
authors: Y
authors: Sun
authors: Ping
authors: P
authors: Chai
authors: Adrian
authors: A
authors: Low
authors: Sim Heng
authors: SH
authors: Ong
mesh_terms: D000465:Algorithms; D002309:Cardiology / Q000379:methods*; D003287:Contrast Media / Q000494:pharmacology; D004699:Endocardium / Q000473:pathology; D005682:Gadolinium / Q000494:pharmacology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D015233:Models, Statistical; D009206:Myocardium / Q000473:pathology*; D010496:Pericardium / Q000473:pathology; D015203:Reproducibility of Results
chemical_list: D003287:Contrast Media; D005682:Gadolinium