title: Acetylation regulates monopolar attachment at multiple levels during meiosis I in fission yeast.
abstract: In fission yeast, meiotic mono-orientation of sister kinetochores is established by cohesion at the core centromere, which is established by a meiotic cohesin complex and the kinetochore protein Moa1. The cohesin subunit Psm3 is acetylated by Eso1 and deacetylated by Clr6. We show that in meiosis, Eso1 is required for establishing core centromere cohesion during S phase, whereas Moa1 is required for maintaining this cohesion after S phase. The clr6-1 mutation suppresses the mono-orientation defect of moa1Δ cells, although the Clr6 target for this suppression is not Psm3. Thus, several acetylations are crucial for establishing and maintaining core centromere cohesion.
authors: Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
authors: Ayano
authors: A
authors: Kagami
authors: Takeshi
authors: T
authors: Sakuno
authors: Yuya
authors: Y
authors: Yamagishi
authors: Tadashi
authors: T
authors: Ishiguro
authors: Tatsuya
authors: T
authors: Tsukahara
authors: Katsuhiko
authors: K
authors: Shirahige
authors: Koichi
authors: K
authors: Tanaka
authors: Yoshinori
authors: Y
authors: Watanabe
mesh_terms: D000107:Acetylation; D004261:DNA Replication; D008540:Meiosis; D049469:Meiotic Prophase I; D008954:Models, Biological; D009154:Mutation / Q000235:genetics; D021122:Protein Subunits / Q000378:metabolism; D012568:Schizosaccharomyces / Q000166:cytology* / Q000378:metabolism*; D029702:Schizosaccharomyces pombe Proteins / Q000378:metabolism
chemical_list: D021122:Protein Subunits; D029702:Schizosaccharomyces pombe Proteins