title: CRMP5 regulates generation and survival of newborn neurons in olfactory and hippocampal neurogenic areas of the adult mouse brain.
abstract: The Collapsin Response Mediator Proteins (CRMPS) are highly expressed in the developing brain, and in adult brain areas that retain neurogenesis, ie: the olfactory bulb (OB) and the dentate gyrus (DG). During brain development, CRMPs are essentially involved in signaling of axon guidance and neurite outgrowth, but their functions in the adult brain remain largely unknown. CRMP5 has been initially identified as the target of auto-antibodies involved in paraneoplasic neurological diseases and further implicated in a neurite outgrowth inhibition mediated by tubulin binding. Interestingly, CRMP5 is also highly expressed in adult brain neurogenic areas where its functions have not yet been elucidated. Here we observed in both neurogenic areas of the adult mouse brain that CRMP5 was present in proliferating and post-mitotic neuroblasts, while they migrate and differentiate into mature neurons. In CRMP5(-/-) mice, the lack of CRMP5 resulted in a significant increase of proliferation and neurogenesis, but also in an excess of apoptotic death of granule cells in the OB and DG. These findings provide the first evidence that CRMP5 is involved in the generation and survival of newly generated neurons in areas of the adult brain with a high level of activity-dependent neuronal plasticity.
authors: Team Neuroplasticity and Neuropathology of Olfactory Perception, Lyon Neuroscience Research Center INSERM U 1028/CNRS UMR 5292, Université de Lyon - Université Claude Bernard Lyon 1, Lyon, France.
authors: Alexandra
authors: A
authors: Veyrac
authors: Sophie
authors: S
authors: Reibel
authors: Joëlle
authors: J
authors: Sacquet
authors: Mireille
authors: M
authors: Mutin
authors: Jean-Philippe
authors: JP
authors: Camdessanche
authors: Pappachan
authors: P
authors: Kolattukudy
authors: Jérôme
authors: J
authors: Honnorat
authors: François
authors: F
authors: Jourdan
mesh_terms: D000375:Aging / Q000378:metabolism*; D000581:Amidohydrolases / Q000172:deficiency / Q000378:metabolism*; D000818:Animals; D002452:Cell Count; D016923:Cell Death; D049109:Cell Proliferation; D002470:Cell Survival; D018891:Dentate Gyrus / Q000166:cytology / Q000378:metabolism; D000089622:Doublecortin Domain Proteins; D005455:Fluorescent Antibody Technique; D006624:Hippocampus / Q000166:cytology* / Q000378:metabolism; D006867:Hydrolases; D051379:Mice; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D055495:Neurogenesis; D009474:Neurons / Q000166:cytology* / Q000378:metabolism*; D009479:Neuropeptides / Q000378:metabolism; D009830:Olfactory Bulb / Q000166:cytology* / Q000378:metabolism
chemical_list: D000089622:Doublecortin Domain Proteins; D008869:Microtubule-Associated Proteins; D009479:Neuropeptides; C501733:Dpysl5 protein, mouse; D006867:Hydrolases; D000581:Amidohydrolases