title: Long-chain lipids are required for the innate immune recognition of trehalose diesters by macrophages.
abstract: Going to any length? Trehalose diesters of various chain lengths have been synthesised in order to determine the effect of lipid length on innate immune recognition, as determined by NO and cytokine production by macrophages. In this work, we show that longer lipids (C(20) -C(26)) are required for macrophage activation, with C(22) giving optimal activity.
authors: Malaghan Institute of Medical Research, Wellington 6242, New Zealand.
authors: Ashna A
authors: AA
authors: Khan
authors: Stephanie H
authors: SH
authors: Chee
authors: Rene J
authors: RJ
authors: McLaughlin
authors: Jacquie L
authors: JL
authors: Harper
authors: Faustin
authors: F
authors: Kamena
authors: Mattie S M
authors: MS
authors: Timmer
authors: Bridget L
authors: BL
authors: Stocker
mesh_terms: D000818:Animals; D003311:Cord Factors / Q000737:chemistry / Q000276:immunology; D016207:Cytokines / Q000378:metabolism; D007113:Immunity, Innate; D008055:Lipids / Q000737:chemistry* / Q000276:immunology; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009569:Nitric Oxide / Q000378:metabolism; D014199:Trehalose / Q000737:chemistry* / Q000276:immunology
chemical_list: D003311:Cord Factors; D016207:Cytokines; D008055:Lipids; D009569:Nitric Oxide; D014199:Trehalose