title: A new regulator of the vacuolar H(+)-ATPase in the kidney.
abstract: Xu et al. identify Slc26a11, a novel member of the Slc26 anion exchanger family, as an electrogenic (Cl(-))(n)/HCO(3)(-) exchanger. Functional characterization of this transporter suggests that Slc26a11 mediates classical electroneutral Cl(-)/HCO(3)(-) exchange but also exhibits an electrogenic Cl(-) conductance. In the kidney, Slc26a11 colocalizes with the vacuolar H(+)-ATPase in intercalated cells, emphasizing the cooperation of the proton pump with chloride transporters.
authors: Centre de Recherche des Cordeliers, Équipe de Recherche Labellisée (ERL) Centre National de la Recherche Scientifique (CNRS) 7226, INSERM UMRS 872 (Équipe 3), Université Pierre et Marie Curie, Paris, France; Département de Physiologie, Hôpital Européen Georges-Pompidou-Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France; Faculté de Médecine Paris Descartes, Université Paris Descartes, Paris, France. Electronic address: dominique.eladari@crc.jussieu.fr.
authors: Dominique
authors: D
authors: Eladari
authors: Centre de Recherche des Cordeliers, Équipe de Recherche Labellisée (ERL) Centre National de la Recherche Scientifique (CNRS) 7226, INSERM UMRS 872 (Équipe 3), Université Pierre et Marie Curie, Paris, France.
authors: Jacques
authors: J
authors: Teulon
mesh_terms: D000818:Animals; D027321:Anion Transport Proteins / Q000378:metabolism*; D002712:Chlorides / Q000378:metabolism*; D007685:Kidney Tubules, Collecting / Q000201:enzymology*; D000076988:Sulfate Transporters; D025262:Vacuolar Proton-Translocating ATPases / Q000378:metabolism*
chemical_list: D027321:Anion Transport Proteins; D002712:Chlorides; C513264:Slc26a2 protein, mouse; D000076988:Sulfate Transporters; D025262:Vacuolar Proton-Translocating ATPases