title: The role of pro-inflammatory and anti-inflammatory adipokines on exercise-induced bronchospasm in obese adolescents undergoing treatment.
abstract: BACKGROUND
  Recent studies have demonstrated a greater prevalence in exercise-induced bronchospasm (EIB) in obese adolescents. However, the role of pro-/anti-inflammatory adipokines and the repercussions of obesity treatment on EIB need to be explored further. Therefore, the objective  of this study was to evaluate the role of pro-/anti-inflammatory adipokines on EIB in obese adolescents evaluated after long-term interdisciplinary therapy.
  
  
  METHODS
  Thirty-five post-pubertal obese adolescents, including 20 non-EIB (body mass index [BMI] 36 ± 5 kg/m(2)) and  15 EIB (BMI 36 ± 5 kg/m(2)), were enrolled in this study. Body composition was measured by plethysmography, using the BOD POD body composition system, and visceral fat was analyzed by ultrasound. Serum levels of adiponectin and leptin were analyzed. EIB and lung function were  evaluated according to the American Thoracic Society criteria. Patients were recruited to a 1-year interdisciplinary intervention of weight loss, consisting of medical, nutritional, exercise, and psychological components.
  
  
  RESULTS
  Anthropometrics and lung function variables improved significantly  after the therapy in both groups. Furthermore we observed a reduction in EIB occurrence in obese adolescents after treatment. There was an increase in adiponectin levels and a reduction in leptin levels after the therapy. In addition, a low FEV(1) value was a risk factor associated  with EIB occurrence at baseline, and was correlated after treatment with changes in anthropometric and maximal O(2) consumption values as well as the adipokines profile.
  
  
  CONCLUSIONS
  In the present study it was demonstrated that 1 year of interdisciplinary therapy decreased EIB frequency  in obese adolescents, paralleled by an increase in lung function and improvement in pro-/anti-inflammatory adipokines.
authors: Universidade Federal de São Paulo, São Paulo, Brazil. patricialeao@ceperb.org
authors: Patrícia Leão
authors: PL
authors: da Silva
authors: Marco Túlio
authors: MT
authors: de Mello
authors: Nadia Carla
authors: NC
authors: Cheik
authors: Priscila Lima
authors: PL
authors: Sanches
authors: Aline
authors: A
authors: Piano
authors: Flávia Campos
authors: FC
authors: Corgosinho
authors: Raquel Munhoz da Silveira
authors: RM
authors: Campos
authors: June
authors: J
authors: Carnier
authors: Daniela
authors: D
authors: Inoue
authors: Claudia Mo
authors: CM
authors: do Nascimento
authors: Lila M
authors: LM
authors: Oyama
authors: Lian
authors: L
authors: Tock
authors: Sérgio
authors: S
authors: Tufik
authors: Ana R
authors: AR
authors: Dâmaso
mesh_terms: D054392:Adipokines / Q000502:physiology*; D052242:Adiponectin / Q000097:blood; D000293:Adolescent; D001250:Asthma, Exercise-Induced / Q000453:epidemiology / Q000503:physiopathology*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D020738:Leptin / Q000097:blood; D016015:Logistic Models; D008297:Male; D009765:Obesity / Q000453:epidemiology*; D010101:Oxygen Consumption; D055815:Young Adult
chemical_list: D054392:Adipokines; D052242:Adiponectin; D020738:Leptin