title: Anti-inflammatory activity of alkaloids: an update from 2000 to 2010.
abstract: Many natural substances with proven anti-inflammatory activity have been isolated throughout the years. The aim of this review is to review naturally sourced alkaloids with anti-inflammatory effects reported from 2000 to 2010. The assays were conducted mostly in vivo, and carrageenan-induced pedal edema was the most used experimental model. Of the 49 alkaloids evaluated, 40 demonstrated anti-inflammatory activity. Of these the most studied type were the isoquinolines. This review was based on NAPRALERT data bank, Web of Science and Chemical Abstracts. In this review, 95 references are cited.
authors: Laboratory of Pharmaceutical Technology, Federal University of Paraiba, 58051-900, João Pessoa-PB, Brazil. augustosouto@gmail.com
authors: Augusto Lopes
authors: AL
authors: Souto
authors: Josean Fechine
authors: JF
authors: Tavares
authors: Marcelo Sobral
authors: MS
authors: da Silva
authors: Margareth de Fátima Formiga Melo
authors: Mde F
authors: Diniz
authors: Petrônio Filgueiras
authors: PF
authors: de Athayde-Filho
authors: José Maria
authors: JM
authors: Barbosa Filho
mesh_terms: D000470:Alkaloids / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D018836:Inflammation Mediators / Q000494:pharmacology*; D007546:Isoquinolines / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D010936:Plant Extracts / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000470:Alkaloids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D018836:Inflammation Mediators; D007546:Isoquinolines; D010936:Plant Extracts