title: Functional platform for controlled subcellular distribution of carbon nanotubes.
abstract: As nanoparticles can cross different cellular barriers and access different tissues, control of their uptake and cellular fate presents a functional approach that will be broadly applicable to nanoscale technologies in cell biology. Here we show that the trafficking of single-walled carbon nanotubes (SWCNTs) through various subcellular membranes of the plant cell is facilitated or inhibited by attaching a suitable functional tag and controlling medium components. This enables a unique control over the uptake and the subcellular distribution of SWCNTs and provides a key strategy to promote their cellular elimination to minimize toxicity. Our results also demonstrate that SWCNTs are involved in a carrier-mediated transport (CMT) inside cells; this is a phenomenon that scientists could use to obtain novel molecular insights into CMT, with the potential translation to advances in subcellular nanobiology.
authors: Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Japan. magedserag@yahoo.com
authors: Maged F
authors: MF
authors: Serag
authors: Noritada
authors: N
authors: Kaji
authors: Enrica
authors: E
authors: Venturelli
authors: Yukihiro
authors: Y
authors: Okamoto
authors: Kazuyoshi
authors: K
authors: Terasaka
authors: Manabu
authors: M
authors: Tokeshi
authors: Hajime
authors: H
authors: Mizukami
authors: Kevin
authors: K
authors: Braeckmans
authors: Alberto
authors: A
authors: Bianco
authors: Yoshinobu
authors: Y
authors: Baba
mesh_terms: D001692:Biological Transport; D030008:Catharanthus / Q000166:cytology; D005089:Exocytosis; D036681:Fluorescence Recovery After Photobleaching; D005456:Fluorescent Dyes / Q000378:metabolism; D042541:Intracellular Space / Q000378:metabolism*; D037742:Nanotubes, Carbon; D013499:Surface Properties; D014617:Vacuoles / Q000378:metabolism
chemical_list: D005456:Fluorescent Dyes; D037742:Nanotubes, Carbon