title: Genes under positive selection in Mycobacterium tuberculosis.
abstract: We employed an evolutionary genomics approach to detect genes under lineage-specific positive selection for the two closely related Mycobacterium tuberculosis strains, the virulent H37Rv and the avirulent H37Ra, with the clinical isolate CDC1551 as the outgroup. We found six H37Rv-specific and six H37Ra-specific positively selected genes, among which the former comprised a flavoprotein, a RNA polymerase sigma factor SigM, two PPE family proteins, as well as two hypothetical proteins, while the latter consisted of a dehydrogenase, a (3R)-hydroxyacyl-ACP dehydratase subunit HadA, a PPE family protein, and three PE-PGRS family proteins. Obviously, the PE/PPE/PE-PGRS family proteins were the main targets of positive selection. The functional discussion of our findings implied that those positively selected genes were highly involved in antigen variations and immune evasions of Mycobacterium tuberculosis.
authors: State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100176, China. yuanzhang@ipb.pumc.edu.cn
authors: Yuan
authors: Y
authors: Zhang
authors: Hong
authors: H
authors: Zhang
authors: Tianyin
authors: T
authors: Zhou
authors: Yang
authors: Y
authors: Zhong
authors: Qi
authors: Q
authors: Jin
mesh_terms: D000942:Antigens, Bacterial / Q000235:genetics; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics; D005798:Genes, Bacterial; D056726:Genetic Association Studies; D016680:Genome, Bacterial; D006801:Humans; D008957:Models, Genetic; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity; D012641:Selection, Genetic; D014397:Tuberculosis, Pulmonary / Q000382:microbiology; D014774:Virulence / Q000235:genetics
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins