title: IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens.
abstract: Interleukin 17 receptor E (IL-17RE) is an orphan receptor of the IL-17 receptor family. Here we show that IL-17RE is a receptor specific to IL-17C and has an essential role in host mucosal defense against infection. IL-17C activated downstream signaling through IL-17RE-IL-17RA complex for the induction of genes encoding antibacterial peptides as well as proinflammatory molecules. IL-17C was upregulated in colon epithelial cells during infection with Citrobacter rodentium and acted in synergy with IL-22 to induce the expression of antibacterial peptides in colon epithelial cells. Loss of IL-17C-mediated signaling in IL-17RE-deficient mice led to lower expression of genes encoding antibacterial molecules, greater bacterial burden and early mortality during infection. Together our data identify IL-17RE as a receptor of IL-17C that regulates early innate immunity to intestinal pathogens.
authors: The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors: Xinyang
authors: X
authors: Song
authors: Shu
authors: S
authors: Zhu
authors: Peiqing
authors: P
authors: Shi
authors: Yan
authors: Y
authors: Liu
authors: Yufang
authors: Y
authors: Shi
authors: Steven D
authors: SD
authors: Levin
authors: Youcun
authors: Y
authors: Qian
mesh_terms: D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000235:genetics / Q000276:immunology; D002460:Cell Line; D044082:Citrobacter rodentium; D003106:Colon / Q000276:immunology / Q000378:metabolism; D004756:Enterobacteriaceae Infections / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D005786:Gene Expression Regulation; D057809:HEK293 Cells; D019073:HT29 Cells; D006801:Humans; D018928:Immunity, Mucosal / Q000235:genetics / Q000276:immunology*; D020381:Interleukin-17 / Q000378:metabolism*; D007378:Interleukins / Q000378:metabolism; D007413:Intestinal Mucosa / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D053722:Receptors, Interleukin-17 / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D000097043:Interleukin-22
chemical_list: D023181:Antimicrobial Cationic Peptides; D020381:Interleukin-17; D007378:Interleukins; D053722:Receptors, Interleukin-17; D000097043:Interleukin-22; C109985:IL17RA protein, human