title: Dedifferentiated adamantinoma associated with fibrous dysplasia.
abstract: A 21-year-old patient presented with an aggressive lesion of the left tibia associated to lymph nodes and lung metastasis. Histological examination revealed a high grade spindle cell sarcoma involving some areas of cytokeratine positive cells. Ultrastructural examination showed the presence of epithelial features in the sarcomatoid cells. The diagnosis of dedifferentiated spindle-celled adamantinoma was established. A second lesion of the right tibia was diagnosed as fibrous dysplasia. The patient had a leg amputation. He died 2 years later with multiple lung and bone metastases. The diagnosis of dedifferentiated adamantinoma should be considered when a clinician is confronted with a tibial biopsy of a "keratin-positive sarcoma". The association with fibrous dysplasia in this case is discussed.
authors: Department of Adult Surgery, Kassab's Institute, University El Manar II, 2010 Mannouba, Tunisia. nourihabib@yahoo.fr
authors: H
authors: H
authors: Nouri
authors: H
authors: H
authors: Jaafoura
authors: M
authors: M
authors: Bouaziz
authors: M
authors: M
authors: Ouertatani
authors: L
authors: L
authors: Abid
authors: M H
authors: MH
authors: Meherzi
authors: M F
authors: MF
authors: Ladeb
authors: M
authors: M
authors: Mestiri
mesh_terms: D050398:Adamantinoma / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D001859:Bone Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D005357:Fibrous Dysplasia of Bone / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D013977:Tibia; D055815:Young Adult