title: t⁴ workshop report. Nanotoxicology: "the end of the beginning" - signs on the roadmap to a strategy for assuring the safe application and use of nanomaterials.
abstract: In October 2010, a group of experts met as part of the transatlantic think tank for toxicology (t4) to exchange ideas about the current status and future of safety testing of nanomaterials. At present, there is no widely accepted path forward to assure appropriate and effective hazard identification for engineered nanomaterials. The group discussed needs for characterization of nanomaterials and identified testing protocols that incorporate the use of innovative alternative whole models such as zebrafish or C. elegans, as well as in vitro or alternative methods to examine specific functional pathways and modes of action. The group proposed elements of a potential testing scheme for nanomaterials that works towards an integrated testing strategy, incorporating the goals of the NRC report Toxicity Testing in the 21st Century: A Vision and a Strategy by focusing on pathways of toxic response, and utilizing an evidence-based strategy for developing the knowledge base for safety assessment. Finally, the group recommended that a reliable, open, curated database be developed that interfaces with existing databases to enable sharing of information.
authors: Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
authors: Ellen K
authors: EK
authors: Silbergeld
authors: Elizabeth Q
authors: EQ
authors: Contreras
authors: Thomas
authors: T
authors: Hartung
authors: Cordula
authors: C
authors: Hirsch
authors: Helena
authors: H
authors: Hogberg
authors: Ashish C
authors: AC
authors: Jachak
authors: William
authors: W
authors: Jordan
authors: Robert
authors: R
authors: Landsiedel
authors: Jeffery
authors: J
authors: Morris
authors: Anil
authors: A
authors: Patri
authors: Joel G
authors: JG
authors: Pounds
authors: Andrea
authors: A
authors: de Vizcaya Ruiz
authors: Anna
authors: A
authors: Shvedova
authors: Robert
authors: R
authors: Tanguay
authors: Norihasa
authors: N
authors: Tatarazako
authors: Erwin
authors: E
authors: van Vliet
authors: Nigel J
authors: NJ
authors: Walker
authors: Mark
authors: M
authors: Wiesner
authors: Neil
authors: N
authors: Wilcox
authors: Joanne
authors: J
authors: Zurlo
mesh_terms: D000826:Animal Testing Alternatives / Q000379:methods; D000818:Animals; D017173:Caenorhabditis elegans; D017387:Investigational New Drug Application; D008954:Models, Biological; D049329:Nanostructures / Q000737:chemistry* / Q000633:toxicity*; D004364:Pharmaceutical Preparations / Q000737:chemistry; D018675:Toxicity Tests / Q000379:methods*; D014481:United States; D014486:United States Food and Drug Administration; D015027:Zebrafish
chemical_list: D004364:Pharmaceutical Preparations