title: Orf-I and orf-II-encoded proteins in HTLV-1 infection and persistence.
abstract: The 3' end of the human T-cell leukemia/lymphoma virus type-1 (HTLV-1) genome contains four overlapping open reading frames (ORF) that encode regulatory proteins. Here, we review current knowledge of HTLV-1 orf-I and orf-II protein products. Singly spliced mRNA from orf-I encodes p12, which can be proteolytically cleaved to generate p8, while differential splicing of mRNA from orf-II results in production of p13 and p30. These proteins have been demonstrated to modulate transcription, apoptosis, host cell activation and proliferation, virus infectivity and transmission, and host immune responses. Though these proteins are not essential for virus replication in vitro, p8, p12, p13, and p30 have an important role in the establishment and maintenance of HTLV-1 infection in vivo.
authors: Animal Models and Retroviral Vaccines Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, MD 20892, USA. edwardsd2@mail.nih.gov
authors: Dustin
authors: D
authors: Edwards
authors: Claudio
authors: C
authors: Fenizia
authors: Heather
authors: H
authors: Gold
authors: Maria Fernanda
authors: MF
authors: de Castro-Amarante
authors: Cody
authors: C
authors: Buchmann
authors: Cynthia A
authors: CA
authors: Pise-Masison
authors: Genoveffa
authors: G
authors: Franchini
mesh_terms: D000818:Animals; D015490:HTLV-I Infections / Q000821:virology*; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D016366:Open Reading Frames; D012326:RNA Splicing; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D014764:Viral Proteins