title: Chronic supplementation with shark liver oil for reducing tumor growth and cachexia in walker 256 tumor-bearing rats.
abstract: We investigated the effect of chronic supplementation with shark liver oil (SLO), an antitumor supplement source of n-3 fatty acids and 1-O-alkylglycerols, alone and combined with coconut fat (CF), a source of saturated fatty acids, on Walker 256 tumor growth and cachexia. Male rats were supplemented daily and orally with SLO and/or CF (1 g per kg body weight) for 7 wk. After 7 wk, 50% of animals were subcutaneously inoculated with 3 × 10(7) Walker 256 tumor cells. After 14 days, the rats were killed, the tumors were removed for lipid peroxidation measurement, and blood was collected for glycemia, triacylglycerolemia, and lacticidemia evaluation. Liver samples were obtained for glycogen measurement. Unlike CF, supplementation with SLO promoted gain in body weight, reduction of tumor weight, and maintained glycemia, triacylglycerolemia, lacticidemia, and liver glycogen content to values similar to non-tumor-bearing rats. Combined supplementation of SLO with CF also showed a reversion of cachexia with gain in body mass, reduction of lacticidemia, maintaining the liver glycogen store, and reduction in tumor weight. SLO, alone or combined with CF, promoted increase of tumor lipid peroxidation. In conclusion, SLO supplemented chronically, alone or associated with CF, was able to reduce tumor growth and cachexia.
authors: Area of Biological and Health Sciences, West University of Santa Catarina, Joaçaba, Brazil. fabiola.iagher@unoesc.edu.br
authors: Fabíola
authors: F
authors: Iagher
authors: Sérgio Ricardo
authors: SR
authors: de Brito Belo
authors: Katya
authors: K
authors: Naliwaiko
authors: Andressa Machado
authors: AM
authors: Franzói
authors: Gleisson Alisson Pereira
authors: GA
authors: de Brito
authors: Ricardo Key
authors: RK
authors: Yamazaki
authors: Ana Lúcia
authors: AL
authors: Muritiba
authors: Luis Alexandre
authors: LA
authors: Muehlmann
authors: Jovani Antonio
authors: JA
authors: Steffani
authors: Luiz Cláudio
authors: LC
authors: Fernandes
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002100:Cachexia / Q000188:drug therapy*; D002279:Carcinoma 256, Walker / Q000188:drug therapy* / Q000473:pathology; D000074263:Coconut Oil; D019587:Dietary Supplements; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage; D005395:Fish Oils / Q000008:administration & dosage*; D005990:Glycerol / Q000008:administration & dosage / Q000031:analogs & derivatives; D019344:Lactic Acid / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects; D008054:Lipid Peroxides / Q000032:analysis; D008112:Liver Glycogen / Q000032:analysis; D008297:Male; D010938:Plant Oils / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D012754:Sharks; D014280:Triglycerides / Q000097:blood
chemical_list: D016588:Anticarcinogenic Agents; D001786:Blood Glucose; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D008054:Lipid Peroxides; D008112:Liver Glycogen; D010938:Plant Oils; D014280:Triglycerides; D019344:Lactic Acid; D005990:Glycerol; D000074263:Coconut Oil