title: Increased risk of trigeminal neuralgia after hypertension: a population-based study.
abstract: OBJECTIVE
  Very few studies have explored the temporal relationship between hypertension and trigeminal neuralgia (TN). The aim of this population-based follow-up study was to investigate whether hypertension is associated with a higher risk of developing TN.
  
  
  METHODS
  A total of 138,492 persons with at least 2 ambulatory visits with the principal diagnosis of hypertension in 2001 were enrolled in the hypertension group. The nonhypertension group consisted of 276,984 age- and sex-matched, randomly sampled subjects without hypertension. The 3-year TN-free survival rate and the cumulative incidence of TN were calculated using the Kaplan-Meier method. Cox proportional hazard regression was used to estimate the hazard ratio of TN.
  
  
  RESULTS
  In the hypertension group, 121 patients developed TN during follow-up, while, in the nonhypertension group, 167 subjects developed TN. The crude hazard ratio for the hypertension group was 1.52 (95% confidence interval [CI] 1.20-1.92; p = 0.0005), while, after adjustment for demographic characteristics and medical comorbidities, the adjusted hazard ratio was 1.51 (95% CI 1.19-1.90; p = 0.0006).
  
  
  CONCLUSIONS
  This study shows a significantly increased risk of developing TN after hypertension. Further studies are needed to elucidate the underlying mechanism of the association between hypertension and TN.
authors: Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan. panslcb@gmail.com
authors: S-L
authors: SL
authors: Pan
authors: M-F
authors: MF
authors: Yen
authors: Y-H
authors: YH
authors: Chiu
authors: L-S
authors: LS
authors: Chen
authors: H-H
authors: HH
authors: Chen
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D018672:Community Health Planning; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000453:epidemiology* / Q000401:mortality; D015994:Incidence; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D013624:Taiwan; D014277:Trigeminal Neuralgia / Q000150:complications* / Q000453:epidemiology* / Q000401:mortality