title: Role of Helicobacter pylori in the pathogenesis of infantile hypertrophic pyloric stenosis.
abstract: OBJECTIVE
  To investigate the possible correlation between infantile hypertrophic pyloric stenosis (IHPS) and Helicobacter pylori infection.
  
  
  METHODS
  In a case-control study, 20 infants with confirmed IHPS (Group 1) and 30 age-matched healthy infants (Group 2) were enrolled for the assessment of H. pylori infection. Serological testing of anti-H. pylori antibody (IgG) was performed preoperatively on all infants and their mothers. Also, H. pylori stool antigen test (HpSA) was carried out preoperatively on all infants in both groups. Statistical analyses were performed with Chi-square test, Fisher's exact test, Mann-Whitney U test, and Independent-Samples T test.
  
  
  RESULTS
  There were 20 patients in group 1 (18 boys, 2 girls) and 30 infants in group 2 (30 boys). The mean age in groups 1 and 2 were 42.40±18.09 days and 44.67±12.65 days, respectively. The numbers of positive HpSA and positive anti-H. pylori antibody both in infants and mothers were comparable between the two groups (P>0.05). The median titres of H. pylori stool antigen were not comparable between the two groups (0.20 ng/dL in group 1 vs 0.57 ng/dL in group 2; P=0.02).
  
  
  CONCLUSIONS
  H. pylori does not seem to be in a causative linkage with IHPS.
authors: Pediatric Health Research Center, Tabriz University of Medical Sciences, Iran.
authors: Saeid
authors: S
authors: Aslanabadi
authors: Mandana
authors: M
authors: Rafeey
authors: Diana
authors: D
authors: Diaz
authors: Davood
authors: D
authors: Pourhossein
authors: Kamyar
authors: K
authors: Ghabili
authors: Mohammadali M
authors: MM
authors: Shoja
authors: Devendra K
authors: DK
authors: Gupta
mesh_terms: D000907:Antibodies, Bacterial / Q000032:analysis; D000942:Antigens, Bacterial / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D016481:Helicobacter Infections / Q000150:complications* / Q000382:microbiology; D016480:Helicobacter pylori / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D008297:Male; D046248:Pyloric Stenosis, Hypertrophic / Q000175:diagnosis / Q000209:etiology*; D012189:Retrospective Studies
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial