title: Erythroid crisis caused by parvovirus B19 transmitted via red blood cell transfusion.
abstract: A 41-year-old man with hairy cell leukemia developed erythroid crisis after the transfusion of red cell concentrate. He was diagnosed with Parvovirus B19 infection based upon the presence of B19-specific IgM antibody and viral DNA in the sera. The repository sample from the corresponding red cell concentrate was negative for B19 antigen by red cell hemo-agglutination method, but was found to contain B19 virus DNA. Furthermore, a genomic PCR direct sequencing showed that B19 in both patient's sera and repository sample were identical. This is the first report directly demonstrating the transmission of B19 through B19 antigen-negative red cell concentrate transfusion. Further accumulation of the cases is warranted to estimate its incidence and to reconsider the screening methods of blood products.
authors: Division of Hematology, Department of Internal Medicine, Keio University School of Medicine, Japan. yuiko.tsukada@gmail.com
authors: Yuiko
authors: Y
authors: Tsukada
authors: Kenji
authors: K
authors: Yokoyama
authors: Akaru
authors: A
authors: Ishida
authors: Makoto
authors: M
authors: Handa
authors: Takehiko
authors: T
authors: Mori
authors: Masahiro
authors: M
authors: Kizaki
authors: Shinichiro
authors: S
authors: Okamoto
mesh_terms: D000328:Adult; D017707:Erythrocyte Transfusion / Q000009:adverse effects*; D041905:Erythroid Cells; D006801:Humans; D008297:Male; D010322:Parvoviridae Infections / Q000097:blood / Q000635:transmission*; D016732:Parvovirus B19, Human