title: Inflammatory and genotoxic effects of sanding dust generated from nanoparticle-containing paints and lacquers.
abstract: Nanoparticles are increasingly used in paints and lacquers. Little is known of the toxicity of nanoparticles incorporated in complex matrices and released during different phases of the life cycle. DNA damaging activity and inflammogenicity of sanding dust sampled during standardised sanding of boards painted with paints with and without nanoparticles were determined 24 h after intratracheal instillation of a single dose of 54 μg in mice. Dusts from nanoparticle-containing paints and lacquers did not generate pulmonary inflammation or oxidative stress. Sanding dust from both the nanoparticle-containing and the conventional lacquer and the outdoor acrylic-based reference paint increased the level of DNA strand breaks in bronchoalveolar fluid cells. In conclusion, addition of nanoparticles to paint or lacquers did not increase the potential of sanding dust for causing inflammation, oxidative stress or DNA damage, suggesting that the paint/lacquer matrix is more important as determinant of DNA damage than the nanomaterial.
authors: The National Research Centre for the Working Environment, Lersø Parkallé 105, DK-2100 Copenhagen, Denmark. ats@nrcwe.dk
authors: Anne Thoustrup
authors: AT
authors: Saber
authors: Ismo Kalevi
authors: IK
authors: Koponen
authors: Keld Alstrup
authors: KA
authors: Jensen
authors: Nicklas Raun
authors: NR
authors: Jacobsen
authors: Lone
authors: L
authors: Mikkelsen
authors: Peter
authors: P
authors: Møller
authors: Steffen
authors: S
authors: Loft
authors: Ulla
authors: U
authors: Vogel
authors: Håkan
authors: H
authors: Wallin
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D020552:Comet Assay; D004249:DNA Damage / Q000187:drug effects*; D004391:Dust; D005260:Female; D007249:Inflammation / Q000139:chemically induced* / Q000378:metabolism; D019570:Inhalation Exposure / Q000009:adverse effects*; D008168:Lung / Q000737:chemistry / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects; D010150:Paint
chemical_list: D004391:Dust