title: Campylobacter jejuni DNA-binding protein from starved cells in Guillain-Barré syndrome patients.
abstract: Campylobacter jejuni enteritis is frequently associated with an axonal form of Guillain-Barré syndrome (GBS) and C. jejuni DNA-binding protein from starved cells (C-Dps) induces paranodal myelin detachment and axonal degeneration through binding with sulfatide in vivo. Here we investigated the invasion of C-Dps into hosts with C. jejuni-related GBS. Our analyses of patient sera found that both C-Dps and anti-C-Dps antibodies were most commonly detected in sera from C. jejuni-related GBS patients (5/27, 14.8% and 15/24, 62.5%; respectively). These findings suggest that C-Dps invades the host and may potentially contribute to the peripheral nerve damage in C. jejuni-related GBS.
authors: Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Nobutoshi
authors: N
authors: Kawamura
authors: Hua
authors: H
authors: Piao
authors: Motozumi
authors: M
authors: Minohara
authors: Takuya
authors: T
authors: Matsushita
authors: Susumu
authors: S
authors: Kusunoki
authors: Hiroshi
authors: H
authors: Matsumoto
authors: Kazuhiro
authors: K
authors: Ikenaka
authors: Yoshimitsu
authors: Y
authors: Mizunoe
authors: Jun-ichi
authors: J
authors: Kira
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001426:Bacterial Proteins / Q000276:immunology / Q000378:metabolism*; D016123:Campylobacter jejuni / Q000276:immunology / Q000378:metabolism*; D002648:Child; D004268:DNA-Binding Proteins / Q000276:immunology / Q000378:metabolism*; D005260:Female; D005677:G(M1) Ganglioside / Q000276:immunology; D020275:Guillain-Barre Syndrome / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; C083911:DPS protein, Bacteria; D005677:G(M1) Ganglioside