title: HIV-1 Virological Synapse: Live Imaging of Transmission.
abstract: A relatively new aspect of HIV-1 biology is the ability of the virus to infect cells by direct cellular contacts across a specialized structure, the virological synapse. This process was recently described through live cell imaging. Together with the accumulated knowledge on cellular and molecular structures involved in cell-to-cell transmission of HIV-1, the visualization of the virological synapse in video-microscopy has brought exciting new hypotheses on its underlying mechanisms. This review will recapitulate current knowledge with a particular emphasis on the questions live microscopy has raised.
authors: Institut Pasteur, Virus and Immunity Unit, URA CNRS 3015, 28 rue du Dr. Roux, 75724 Paris, France.
authors: Jerome
authors: J
authors: Feldmann
authors: Institut Pasteur, Virus and Immunity Unit, URA CNRS 3015, 28 rue du Dr. Roux, 75724 Paris, France.
authors: Olivier
authors: O
authors: Schwartz