title: Hiding in plain sight: how HIV evades innate immune responses.
abstract: Two groups have identified SAMHD1, a protein encoded by an Aicardi-Goutières Syndrome susceptibility gene, as the factor that restricts infection of macrophages and dendritic cells with HIV-1. Here we discuss implications of this discovery for induction of antiviral protective immunity.
authors: Institut Curie-INSERM U, Paris, France. nicolas.manel@curie.fr
authors: Nicolas
authors: N
authors: Manel
authors: Dan R
authors: DR
authors: Littman
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology; D056704:Adaptive Immunity; D020274:Autoimmune Diseases of the Nervous System / Q000235:genetics; D003713:Dendritic Cells / Q000276:immunology; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D057131:Immune Evasion; D007113:Immunity, Innate; D008264:Macrophages / Q000276:immunology / Q000821:virology; D009421:Nervous System Malformations / Q000235:genetics
chemical_list: D016915:AIDS Vaccines