title: Solid state amorphization kinetic of alpha lactose upon mechanical milling.
abstract: It has been previously reported that α-lactose could be totally amorphized by ball milling. In this paper we report a detailed investigation of the structural and microstructural changes by which this solid state amorphization takes place. The investigations have been performed by Powder X-ray Diffraction, Solid State Nuclear Magnetic Resonance ((13)C CP-MAS) and Differential Scanning Calorimetry. The results reveal the structural complexity of the material in the course of its amorphization so that it cannot be considered as a simple mixture made of a decreasing crystalline fraction and an increasing amorphous fraction. Heating this complexity can give rise to a fully nano-crystalline material. The results also show that chemical degradations upon heating are strongly connected to the melting process.
authors: UMET, UMR CNRS 8207, Université Lille Nord de France, F-59650 Villeneuve d'Ascq, France.
authors: Vincent
authors: V
authors: Caron
authors: Jean-François
authors: JF
authors: Willart
authors: Ronan
authors: R
authors: Lefort
authors: Patrick
authors: P
authors: Derollez
authors: Florence
authors: F
authors: Danède
authors: Marc
authors: M
authors: Descamps
mesh_terms: D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D007700:Kinetics; D007785:Lactose / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D055595:Mechanical Phenomena; D044367:Phase Transition; D033362:Powder Diffraction; D013816:Thermodynamics; D014961:X-Ray Diffraction
chemical_list: D007785:Lactose