title: Clinicopathologic characteristics of granulosa cell tumors of the ovary: a multicenter retrospective study.
abstract: OBJECTIVE
  To evaluate the clinicopathologic characteristics and prognostic factors of ovarian granulosa cell tumors.
  
  
  METHODS
  Medical records of 113 patients presenting between January 1995 and December 2007 were retrospectively reviewed.
  
  
  RESULTS
  One-hundred two patients had adult type disease, with a mean age of 46.2 years (range, 18 to 83 years) and a mean follow-up period of 54.7 months (range, 1 to 155 months). The distribution of FIGO stages was 86 patients at stage I, 11 at stage II, and 5 at stage III. During follow-up, ten patients recurred at a mean time of 48 months (range, 4 to 109 months). Among them, three patients died after a mean of 57 months (range, 25 to 103 months). In recurrence analysis, advanced stage (p=0.032) and presence of residual disease (p=0.012) were statistically significant, and age<40 years, premenopause and positive washing cytology were marginally significant (p<0.1). In multivariate analysis, stage was the only factor associated with recurrence; adjuvant chemotherapy and fertility-sparing surgery were not statistically significant. Among 36 patients with fertility-sparing operations, eight patients had nine pregnancies and delivered seven babies. Eleven patients had juvenile type tumors; the mean age was 20.0 years (range, 8 to 45 years) and the mean follow-up period was 69.8 months (range, 20 to 156 months). The distribution of FIGO stage was nine patients at stage I and two at stage III. There were no recurrences or deaths reported. Four patients had seven pregnancies and delivered six babies.
  
  
  CONCLUSIONS
  Stage is the only factor associated with disease-free survival, and fertility-sparing surgery may be a treatment option for women with early-stage disease who want to retain fertility.
authors: Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea.
authors: In Ho
authors: IH
authors: Lee
authors: Chel Hun
authors: CH
authors: Choi
authors: Dae Gy
authors: DG
authors: Hong
authors: Jae Yun
authors: JY
authors: Song
authors: Young Jae
authors: YJ
authors: Kim
authors: Kyung Tai
authors: KT
authors: Kim
authors: Kyu Wan
authors: KW
authors: Lee
authors: Il Soo
authors: IS
authors: Park
authors: Duk Soo
authors: DS
authors: Bae
authors: Tae Jin
authors: TJ
authors: Kim