title: Tumor angiogenesis: pericytes and maturation are not to be ignored.
abstract: Angiogenesis, an essential component of tumor growth and survival, is regulated by complex interactions between several cell types and soluble mediators. Heterogeneous tumor vasculature originates from the collective effect of the nature of carcinoma and the complexity of the angiogenic network. Although the application of angiogenesis inhibitors in some types of cancers has shown clinical benefits, predictive markers to assess treatment effects have yet to be established. In this review, we focus on tumor vessel maturity as a potential marker for evaluating treatment response.
authors: Breast Surgery Department, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
authors: Elham
authors: E
authors: Fakhrejahani
authors: Masakazu
authors: M
authors: Toi