title: [Levels of TNF-α, IL-6 and IL-10 in bronchoalveolar lavage fluid in children with Mycoplasma pneumoniae pneumonia].
abstract: OBJECTIVE
  To study the levels and roles of cytokines TNF-α, IL-6 and IL-10 in bronchoalveolar lavage fluid (BALF) in children with Mycoplasma pneumoniae pneumonia (MPP).
  
  
  METHODS
  The levels of TNF-α, IL-6 and IL-10 in BALF were measured using ELISA in children with MPP at acute stage (n=45) and at remission stage (n=30).  Twenty children without lung lesions severed as the control group.
  
  
  RESULTS
  The TNF-α, IL-6 and IL-10 levels in BALF were higher in children with MPP at acute stage than those in the control group (P<0.05). The levels of TNF-α and IL-6 in BALF at remission stage were reduced to the levels similar to the control group and were significantly lower than those at the acute stage in children with MPP. However, the levels of IL-10 in BALF remained at higher levels at remission stage in children with MPP.
  
  
  CONCLUSIONS
  The levels of TNF-α, IL-6 and IL-10 in BALF increase in children with MPP at acute stage, suggesting that the cytokines may be involved in the pathogenesis of MPP.
authors: Department of Pediatrics, First Hospital of Jilin University, Changchun, China.
authors: Huan-Xiang
authors: HX
authors: Pang
authors: Hong-Mei
authors: HM
authors: Qiao
authors: Huan-Ji
authors: HJ
authors: Cheng
authors: Yun-Feng
authors: YF
authors: Zhang
authors: Xiao-Jun
authors: XJ
authors: Liu
authors: Jun-Zhao
authors: JZ
authors: Li
mesh_terms: D000293:Adolescent; D001992:Bronchoalveolar Lavage Fluid / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000032:analysis*; D015850:Interleukin-6 / Q000032:analysis*; D008297:Male; D011019:Pneumonia, Mycoplasma / Q000209:etiology / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
chemical_list: D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10