title: Successful pregnancy following in vitro fertilization embryo transfer in a 46-year-old woman with diminished oocyte reserve as evidenced by a high day 3 serum estradiol.
abstract: OBJECTIVE
  To establish a precedent that a successful pregnancy is possible following in vitro fertilization-embryo transfer (IVF-ET) even in a 46-year-old woman with diminished egg reserve.
  
  
  METHODS
  Mild ovarian stimulation was used to stimulate multiple follicles in a woman whose diminished oocyte reserve was manifested by elevated day 3 serum estradiol and top normal serum follicle stimulating hormone (FSH).
  
  
  RESULTS
  She conceived on her third IVF-ET attempt. She delivered a healthy full term baby girl.
  
  
  CONCLUSIONS
  This is believed to be the first case report of a successful pregnancy in a woman of this advanced age with diminished oocyte reserve using her own oocytes. It establishes a precedent showing others in similar circumstances that a pregnancy is at least possible though unlikely.
authors: The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology Division of Reproductive Endocrinology & Infertility, Camden, NJ, USA. laurie@ccivf.com
authors: J H
authors: JH
authors: Check
authors: R
authors: R
authors: Chern
authors: J
authors: J
authors: Amui
mesh_terms: D004624:Embryo Transfer; D004958:Estradiol / Q000097:blood*; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D008423:Maternal Age; D008875:Middle Aged; D009865:Oocytes / Q000166:cytology*; D011247:Pregnancy
chemical_list: D004958:Estradiol; D005640:Follicle Stimulating Hormone