title: Inhibition of nonmammalian glycosidases by azetidine iminosugars derived from stable 3,5-di-O-triflates of pentoses.
abstract: Efficient ring closure of stable crystalline 3,5-di-O-triflates of pentofuranosides with amines to form azetidines allowed preliminary evaluation of four-ring iminosugars as glycosidase inhibitors; significant and specific inhibition of nonmammalian α-glucosidases is shown by L-xylo- and L-arabino-iminosugar azetidines.
authors: Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.
authors: Gabriel M J
authors: GM
authors: Lenagh-Snow
authors: Noelia
authors: N
authors: Araujo
authors: Sarah F
authors: SF
authors: Jenkinson
authors: Catherine
authors: C
authors: Rutherford
authors: Shinpei
authors: S
authors: Nakagawa
authors: Atsushi
authors: A
authors: Kato
authors: Chu-Yi
authors: CY
authors: Yu
authors: Alexander C
authors: AC
authors: Weymouth-Wilson
authors: George W J
authors: GW
authors: Fleet
mesh_terms: D000818:Animals; D001384:Azetidines / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors*; D050111:Imino Sugars / Q000138:chemical synthesis* / Q000494:pharmacology; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D001384:Azetidines; D004791:Enzyme Inhibitors; D050111:Imino Sugars; C082735:azetidine; D006026:Glycoside Hydrolases