title: Malignant lymphoma of the lacrimal gland: a nation-based study.
abstract: OBJECTIVE
  To characterize the clinicopathologic features of lacrimal gland lymphoma.
  
  
  METHODS
  All cases of lacrimal gland lymphoma from January 1, 1975, through December 31, 2009, were retrieved from The Danish Registry of Pathology. Histologic specimens were reevaluated using a panel of monoclonal antibodies. Clinical files from all patients with confirmed lymphoma were collected.
  
  
  RESULTS
  Twenty-seven patients with lacrimal gland lymphoma were identified. Eight of the patients were men and 19 were women; the median (range) age was 69 (43-87) years. The distribution of lymphoma subtypes was as follows: extranodal marginal zone lymphoma, 10 (37%); follicular lymphoma, 5 (19%); diffuse large B-cell lymphoma, 4 (15%); mantle cell lymphoma, 3 (11%); chronic lymphocytic leukemia/small lymphatic lymphoma, 2 (7%); and unclassified B-cell lymphoma, 3 (11%). Twenty-two patients (81%) had stage I or II lymphoma, 1 patient (4%) had stage III lymphoma, and 4 patients (15%) had stage IV lymphoma. Patients with stage I or II lymphoma were treated with radiotherapy (15 [67%]), chemotherapy (3 [14%]), chemotherapy plus radiotherapy (1 [5%]), and surgery (3 [14%]). Patients presenting with stage III or IV lymphoma were treated with chemotherapy alone. Complete remission was observed in 23 of the patients (85%), although 12 (44%) of these had a relapse, independent of subtype, stage, or treatment. The 5-year overall survival was 70%.
  
  
  CONCLUSIONS
  Malignant lymphoma of the lacrimal gland is relatively rare and is mostly prevalent in elderly women. The distribution of lacrimal gland lymphoma subtypes resembles that of lymphoma subtypes of the salivary glands. The majority of lacrimal gland lymphomas are low grade, and the prognosis is relatively good.
authors: Department of Neuroscience and Pharmacology, Section of Eye Pathology, University of Copenhagen, Copenhagen, Denmark.
authors: Peter
authors: P
authors: Rasmussen
authors: Elisabeth
authors: E
authors: Ralfkiaer
authors: Jan Ulrik
authors: JU
authors: Prause
authors: Lene D
authors: LD
authors: Sjö
authors: Volkert D
authors: VD
authors: Siersma
authors: Steffen
authors: S
authors: Heegaard
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003718:Denmark / Q000453:epidemiology; D005134:Eye Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D007766:Lacrimal Apparatus Diseases / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D016393:Lymphoma, B-Cell / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D008224:Lymphoma, Follicular / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D020522:Lymphoma, Mantle-Cell / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012042:Registries; D015996:Survival Rate; D014057:Tomography, X-Ray Computed