title: Antigenicity, animal protective effect and genetic characteristics of candidate vaccine strains of enterovirus 71.
abstract: Enterovirus 71 (EV71) is one of the major causative agents of hand, foot and mouth disease. Recently, several EV71 inactivated vaccine candidates have been development in mainland China. To compare the antigenicity and genetic characteristics of different candidate vaccine strains for EV71, the genomes of 11 EV71 strains were sequenced. The cross-protection capacities were determined by neutralizing antibody test and were further assessed in neonatal mice. The results showed 93.0%-99.8% genome homology of the VP1 regions, but their cross-neutralization capacities varied. These results showed that vaccine strains with good cross-neutralization capacities had the potential to be vaccine strains.
authors: National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, China.
authors: Qunying
authors: Q
authors: Mao
authors: Nan
authors: N
authors: Li
authors: Xiang
authors: X
authors: Yu
authors: Xin
authors: X
authors: Yao
authors: Fengxiang
authors: F
authors: Li
authors: Fengmin
authors: F
authors: Lu
authors: Hui
authors: H
authors: Zhuang
authors: Zhenglun
authors: Z
authors: Liang
authors: Junzhi
authors: J
authors: Wang
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D002681:China; D056738:Cross Protection; D029821:Enterovirus A, Human / Q000235:genetics / Q000276:immunology*; D006168:Guinea Pigs; D006232:Hand, Foot and Mouth Disease / Q000276:immunology* / Q000517:prevention & control* / Q000821:virology; D051379:Mice; D008813:Mice, Inbred ICR; D009500:Neutralization Tests; D015678:Viral Structural Proteins / Q000235:genetics / Q000276:immunology; D014765:Viral Vaccines / Q000235:genetics* / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D015678:Viral Structural Proteins; D014765:Viral Vaccines