title: Predictors of serological cure and Serofast State after treatment in HIV-negative persons with early syphilis.
abstract: BACKGROUND
  Syphilis management requires serological monitoring after therapy. We compared factors associated with serological response after treatment of early (ie, primary, secondary, or early latent) syphilis.
  
  
  METHODS
  We performed secondary analyses of data from a prospective, randomized syphilis trial conducted in the United States and Madagascar. Human immunodeficiency virus (HIV)-negative participants aged ≥ 18 years with early syphilis were enrolled from 2000-2009. Serological testing was performed at baseline and at 3 and 6 months after treatment. At 6 months, serological cure was defined as a negative rapid plasma reagin (RPR) test or a ≥4-fold decreased titer, and serofast status was defined as a ≤ 2-fold decreased titer or persistent titers that did not meet criteria for treatment failure.
  
  
  RESULTS
  Data were available from 465 participants, of whom 369 (79%) achieved serological cure and 96 (21%) were serofast. In bivariate analysis, serological cure was associated with younger age, fewer sex partners, higher baseline RPR titers, and earlier syphilis stage (P ≤ .008). There was a less significant association with Jarisch-Herxheimer reaction after treatment (P = .08). Multivariate analysis revealed interactions between log-transformed baseline titer with syphilis stage, in which the likelihood of cure was associated with increased titers among participants with primary syphilis (adjusted odds ratio [AOR] for 1 unit change in log(2) titer, 1.83; 95% confidence interval [CI], 1.25-2.70), secondary syphilis (AOR, 3.15; 95% CI, 2.14-4.65), and early latent syphilis (AOR, 1.86; 95% CI, 1.44-2.40).
  
  
  CONCLUSIONS
  Serological cure at 6 months after early syphilis treatment is associated with age, number of sex partners, Jarisch-Herxheimer reaction, and an interaction between syphilis stage and baseline RPR titer.
authors: Division of Infectious Diseases, Department of Medicine, University of North Carolina, Chapel Hill, NC, USA.
authors: Arlene C
authors: AC
authors: Seña
authors: Mark
authors: M
authors: Wolff
authors: David H
authors: DH
authors: Martin
authors: Frieda
authors: F
authors: Behets
authors: Kathleen
authors: K
authors: Van Damme
authors: Peter
authors: P
authors: Leone
authors: Carol
authors: C
authors: Langley
authors: Linda
authors: L
authors: McNeil
authors: Edward W
authors: EW
authors: Hook
mesh_terms: D000293:Adolescent; D000328:Adult; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D008270:Madagascar; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D011935:Reagins / Q000097:blood*; D012698:Serologic Tests; D013587:Syphilis / Q000188:drug therapy*; D016896:Treatment Outcome; D014481:United States; D055815:Young Adult
chemical_list: D011935:Reagins