title: Macular and peripapillary retinal nerve fibre layer thickness in adults with amblyopia.
abstract: OBJECTIVE
  To evaluate macular and peripapillary retinal nerve fiber layer (RNFL) thickness in amblyopic eyes compared to the fellow eye.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  30 patients (60 eyes) older than 18 years of age with amblyopia.
  
  
  METHODS
  Inclusion criteria included individuals older than 18 years, amblyopia, and best-corrected visual acuity (BCVA) ≤ 20/40. A complete medical history was taken and an eye examination carried out. Optical coherence tomography (OCT) was carried out on both eyes of all patients. Exclusion criteria included intraocular pressure (IOP) >23 mm Hg and eye pathology that may affect OCT measurements. The primary outcome measures were foveal thickness and average peripapillary RNFL thickness, which were compared using a paired t test. Quadrants in peripapillary scans and concentric rings in macular scans were analyzed.
  
  
  RESULTS
  The average age was 56 years (range = 33-82 years). Visual acuity ranged from 20/40 to 20/4000 (mean = 20/275). The average peripapillary RNFL thickness was 90.6 μm (SD = 9.6 μm) in the amblyopic eye and 90.1 μm (SD = 12.1 μm) in the fellow eye (p = 0.64). The average macular thickness in amblyopic eyes was 260.1 μm (SD = 32.0 μm), and 254.7 μm (SD = 32.5 μm) in fellow eyes (p = 0.10). No statistical difference existed between peripapillary quadrants or macular concentric rings. These differences were smaller when the strabismic amblyopes were isolated.
  
  
  CONCLUSIONS
  There does not seem to be a difference in peripapillary RNFL or macular thickness between the amblyopic eye and fellow eye.
authors: Department of Ophthalmology, Saskatoon City Hospital, Saskatoon, Saskatchewan. ra.walker@shaw.ca
authors: Randy A
authors: RA
authors: Walker
authors: Shehla
authors: S
authors: Rubab
authors: Alexandra R L
authors: AR
authors: Voll
authors: Vasudha
authors: V
authors: Erraguntla
authors: Paul H
authors: PH
authors: Murphy
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000550:Amblyopia / Q000175:diagnosis*; D003430:Cross-Sectional Studies; D006801:Humans; D008266:Macula Lutea / Q000473:pathology*; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology