title: The effect of water-soluble polymers, PEG and PVP, on the solubilisation of griseofulvin in aqueous micellar solutions of Pluronic F127.
abstract: The purpose of this study was to investigate the possibility of enhancing the solubilisation capacity of micellar solutions of Pluronic F127 for the poorly water-soluble drug griseofulvin by co-formulating with a water-soluble polymer. The effect of the addition of the polyethylene glycols PEG6000 and 35000, and the poly(vinylpyrrolidone)s PVP K30 and K90, on the solubilisation capacity of 1wt% solutions of Pluronic F127 was related to the effect of these additives on particle size as determined by dynamic light scattering measurements. The addition of PEG35000 to 1wt% F127 solutions significantly increased the solubility capacity expressed in terms of unit weight of F127; PVP K90 had a smaller effect but no enhancement was noted following the addition of PEG6000 or PVP K30. Solubilisation enhancement was thought to be a consequence of the association of the polymers with the E-blocks of the micelle corona so providing an expanded region of reduced polarity for drug solubilisation.
authors: Department of Organic and Inorganic Chemistry, Polymer Laboratory, Federal University of Ceará, CX 6.021, CEP 60455-760, Fortaleza, Ceará, Brazil.
authors: Cristiane P
authors: CP
authors: Oliveira
authors: Maria Elenir N P
authors: ME
authors: Ribeiro
authors: Nágila M P S
authors: NM
authors: Ricardo
authors: Ticiane V de P
authors: TV
authors: Souza
authors: Carolina Lima
authors: CL
authors: Moura
authors: Chiraphon
authors: C
authors: Chaibundit
authors: Stephen G
authors: SG
authors: Yeates
authors: Keith
authors: K
authors: Nixon
authors: David
authors: D
authors: Attwood
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry*; D006118:Griseofulvin / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D011092:Polyethylene Glycols / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*; D012995:Solubility; D014867:Water
chemical_list: D000935:Antifungal Agents; D008823:Micelles; D011145:Polyvinyls; D011759:Pyrrolidines; C505150:poly(N-vinylpyrrolidine); D014867:Water; D006118:Griseofulvin; D011092:Polyethylene Glycols