title: Synthesis and biological evaluation of antifungal activities of novel 1,2-trans glycosphingolipids.
abstract: The synthesis and in-vitro biological evaluation of antifungal activities of a series of 1,2-trans glycosphingolipids (GSL) against Candida albicans, Candida parapsilosis, and Candida tropicalis were described. The preliminary study indicated that the sort of sugar moiety of GSLs affected their antifungal activities and selectivities towards the three Candida species, and the permeability might not be the sole parameter affecting their antifungal properties as presumed before, which would bring new clues to understand the antifungal profile for these types of compounds.
authors: Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, P. R. China.
authors: Ning
authors: N
authors: Ding
authors: Wei
authors: W
authors: Zhang
authors: Guokai
authors: G
authors: Lv
authors: Yingxia
authors: Y
authors: Li
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002175:Candida / Q000187:drug effects; D006028:Glycosphingolipids / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D006028:Glycosphingolipids