title: Biocellulose membranes as supports for dermal release of lidocaine.
abstract: Biocellulose (BC) is a highly pure form of cellulose, produced in the form of a swollen membrane, with several applications in the biomedical area. In this study, the behavior of BC membranes as systems for topical delivery of lidocaine was evaluated. The BC-lidocaine membranes were prepared and characterized in terms of structural and morphological properties. A uniform distribution of the drug inside the BC membranes was observed. In vitro diffusion studies with Franz cells were conducted using human epidermal membranes and showed that the permeation rate of the drug in BC membranes was slightly slower than that obtained with the conventional systems, which was attributed to the establishment of interactions between the lidocaine molecules and the BC membrane, as evidenced by FTIR and NMR analysis. These results indicate that this methodology can be successfully applied for the dermal administration of lidocaine regarding the release profile and ease of application.
authors: CICECO and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
authors: Eliane
authors: E
authors: Trovatti
authors: Nuno H C S
authors: NH
authors: Silva
authors: Iola F
authors: IF
authors: Duarte
authors: Catarina F
authors: CF
authors: Rosado
authors: Isabel F
authors: IF
authors: Almeida
authors: Paulo
authors: P
authors: Costa
authors: Carmen S R
authors: CS
authors: Freire
authors: Armando J D
authors: AJ
authors: Silvestre
authors: Carlos Pascoal
authors: CP
authors: Neto
mesh_terms: D000279:Administration, Cutaneous; D000327:Adsorption; D002482:Cellulose / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D055119:Elastic Modulus; D004817:Epidermis / Q000737:chemistry; D006801:Humans; D008012:Lidocaine / Q000737:chemistry*; D008567:Membranes, Artificial; D010539:Permeability; D013499:Surface Properties; D013718:Tensile Strength
chemical_list: D004337:Drug Carriers; D008567:Membranes, Artificial; D002482:Cellulose; D008012:Lidocaine