title: Deep brain stimulation of the pedunculopontine tegmental nucleus may influence renal function.
abstract: Deep brain stimulation of the pedunculopontine tegmental nucleus (PPTg) had usually been reported to improve the symptoms of advanced Parkinson's disease. Previous studies showed that neurons in the PPTg involved in the control of the sympathetic outflow to the kidneys. Our recent studies using transneuronal labeling pseudorabies virus (PRV)-614 supported the sympathetic nature of the caudal PPTg. We propose a hypothesis that deep brain stimulation of the PPTg may influence renal function by serotonergic and catecholaminergic pathways. Because PRV-614/tryptophan hydroxylase and PRV-614/tyrosine hydroxylase double-labeled neurons in the compact parts of PPTg (cpPPTg) were not detected, deep brain stimulation of the cpPPTg might not influence renal function.
authors: Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People's Republic of China.
authors: Hong-Bing
authors: HB
authors: Xiang
authors: Cheng
authors: C
authors: Liu
authors: Qing-Qing
authors: QQ
authors: Guo
authors: Rong-Chun
authors: RC
authors: Li
authors: Da-Wei
authors: DW
authors: Ye
mesh_terms: D046690:Deep Brain Stimulation / Q000379:methods*; D011558:Herpesvirus 1, Suid; D006801:Humans; D007668:Kidney / Q000294:innervation* / Q000502:physiology*; D008954:Models, Biological; D045042:Pedunculopontine Tegmental Nucleus / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000502:physiology*; D014365:Tryptophan Hydroxylase; D014446:Tyrosine 3-Monooxygenase
chemical_list: D014446:Tyrosine 3-Monooxygenase; D014365:Tryptophan Hydroxylase