title: Efficient one-pot preparation of novel fused chromeno[2,3-d]pyrimidine and pyrano[2,3-d]pyrimidine derivatives.
abstract: Some novel chromeno[2,3-d]pyrimidinone, pyrano[2,3-d]pyrimidine, dihydropyrimidine, pyridopyranopyrimidine and pyrimidopyranopyrimidine have been synthesized. The structures of target compounds were confirmed by elemental analyses and spectral data. The antimicrobial activity of all the target synthesized compounds were tested against various microorganismst such as Pseudomonas aeruginosa; Staphylococcus aureus (Bacteria), Aspergillus flavus (Fungus) and Candida albicans (Yeast fungus) by the disc diffusion method. In general, the novel synthesized compounds showed a good antimicrobial activity against the previously mentioned microorganisms.
authors: Department of Chemistry, Faculty of Science (Girl's), Al-Azhar University, PO box 11754, Nasr City, Cairo, Egypt. hala_mali@yahoo.com
authors: Hala M
authors: HM
authors: Aly
authors: Mona M
authors: MM
authors: Kamal
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D001231:Aspergillus flavus / Q000187:drug effects; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D001578:Benzopyrans; D011714:Pyrans; D011743:Pyrimidines; C550867:chromeno(2,3-b)-pyrimidine; C476007:pyrano(2,3-d)pyrimidine