title: Deciphering the role of nuclear factor-κB in cellular senescence.
abstract: Cellular senescence is a program of irreversible cell cycle arrest that cells undergo in response to a variety of intrinsic and extrinsic stimuli including progressive shortening of telomeres, changes in telomeric structure or other forms of genotoxic and non-genotoxic stress. The role of nuclear factor-κB in cellular senescence is controversial, as it has been associated with both proliferation and tumour progression, and also with growth arrest and ageing. This research perspective focuses on the evidence for a functional relationship between NF-κB and senescence, and how disruption of the NF-κB pathway can lead to its bypass.
authors: Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.
authors: Simon
authors: S
authors: Vaughan
authors: Parmjit S
authors: PS
authors: Jat
mesh_terms: D002453:Cell Cycle / Q000502:physiology; D016922:Cellular Senescence / Q000502:physiology*; D006801:Humans; D016328:NF-kappa B / Q000378:metabolism*; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D016615:Telomere / Q000378:metabolism
chemical_list: D016328:NF-kappa B; D011065:Poly(ADP-ribose) Polymerases