title: Development of oral food-grade delivery systems: current knowledge and future challenges.
abstract: In recent years there has been an increasing interest in the development of new and efficient oral food delivery systems as tools to prevent disease and promote human health and well-being. Such vehicles are sought to protect bioactive ingredients added to food while controlling and targeting their release as they pass through the human gastrointestinal tract (GIT). This review aims to summarize the key concepts of food delivery systems, their characterization and evaluation. Particularly, evaluation of their performance within the human GIT is discussed. To this end an overview of several in vivo and in vitro methods currently applied for the study of such systems is given. Although considered to be still in its infancy, this promising field of research is likely to infiltrate into real products through rational design. In order for such efforts to materialize into real products some challenges still need to be met and are discussed herein. Overall, it seems that adopting a comprehensive pharmacological approach and relevant cutting edge tools are likely to facilitate innovations and help elucidate and perhaps tailor delivery systems' behavior in the human GIT.
authors: Laboratory of Functional Foods, Nutraceuticals, and Food Nanaoscience, Department of Biotechnology and Food Engineering, Technion - Israel Institute of Technology, Haifa 32000, Israel.
authors: Revital Cohen
authors: RC
authors: Benshitrit
authors: Carmit Shani
authors: CS
authors: Levi
authors: Sharon Levi
authors: SL
authors: Tal
authors: Eyal
authors: E
authors: Shimoni
authors: Uri
authors: U
authors: Lesmes
mesh_terms: D000284:Administration, Oral; D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods* / Q000523:psychology / Q000639:trends; D004358:Drug Therapy / Q000523:psychology / Q000639:trends; D005503:Food Additives / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D019359:Knowledge; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D005503:Food Additives; D004364:Pharmaceutical Preparations