title: Hydrazonoyl halides as precursors for new fused heterocycles of 5α-reductase inhibitors.
abstract: A new series of benzo[6,7]cyclohepta[1,2-d]triazolo[4,3-a]pyrimidines 8a-l was synthesized via reaction of heterocyclic thione 4 or its methyl derivatives 10 with hydrazonoyl halides 5a-l. Also, reaction of compound 4 with a mixture of chloroacetic acid and aromatic aldehyde derivatives gave benzo[6,7]cyclohepta[1,2-d]thiazolo[3,2-a]pyrimidin-3-ones 12-14. The microanalyses and spectral data of the synthesized compounds are in full agreement with their molecular structure. All the newly synthesized products were screened against 5α-reductase and showed activities with good ED(50)  for all compounds.
authors: Department of Chemistry, Cairo University, Giza, Egypt. thoraya-f@hotmail.com
authors: Thoraya A
authors: TA
authors: Farghaly
authors: Sobhi M
authors: SM
authors: Gomha
authors: Eman M H
authors: EM
authors: Abbas
authors: Mohamed M
authors: MM
authors: Abdalla
mesh_terms: D058891:5-alpha Reductase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D058891:5-alpha Reductase Inhibitors; D006571:Heterocyclic Compounds; D006835:Hydrazones