title: Toxicity and anticancer effects of an extract from Selaginella tamariscina on a mice model.
abstract: The toxicity and antitumour effect of the ethanol extract of Selaginella tamariscina (STE), a plant widely used in folk medicine, were examined in a mice model. In the single-dose acute toxicity test, an oral administration of 10,000 mg kg(-1) STE did not cause any lethality. The sub-acute toxicity study showed that the treatment by 250, 1000 and 3000 mg kg(-1 )day(-1) for 30 continuous days did neither alter the body weights nor the haematological parameters in BALB/c mice. The anticancer effect of STE was evaluated in BALB/c mice inoculated with Lewis lung carcinoma cells. Oral administration of STE could not prevent the tumour formation but provided strong inhibition of tumour growth.
authors: Institute of Natural Product Chemistry (INPC), Vietnam Academy of Science and Technology (VAST), 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam. halm2vn@gmail.com
authors: Minh Ha
authors: MH
authors: Le
authors: Thi Thao
authors: TT
authors: Do
authors: Thanh Huong
authors: TH
authors: Hoang
authors: Van Minh
authors: VM
authors: Chau
authors: Tien Dat
authors: TD
authors: Nguyen
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D007928:Lethal Dose 50; D051379:Mice; D008807:Mice, Inbred BALB C; D023421:Models, Animal; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D032503:Selaginellaceae / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts