title: Treatment of early and established Cryptococcus neoformans infection with radiolabeled antibodies in immunocompetent mice.
abstract: We investigated the utility of radioimmunotherapy (RIT) in early and established cryptococcal infection in immunocompetent mice. RIT with (213)Bi-18B7 antibody completely eliminated fungus from mouse lungs and brains for early infection, while (188)Re-18B7 significantly reduced CFU in the lungs or both lungs and brains during early and established infection, respectively. The results point to the independence of RIT of the immune status of the host, which is encouraging for translation of this strategy into the clinic.
authors: Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
authors: Zewei
authors: Z
authors: Jiang
authors: Ruth A
authors: RA
authors: Bryan
authors: Alfred
authors: A
authors: Morgenstern
authors: Frank
authors: F
authors: Bruchertseifer
authors: Arturo
authors: A
authors: Casadevall
authors: Ekaterina
authors: E
authors: Dadachova
mesh_terms: D000818:Animals; D000908:Antibodies, Fungal / Q000008:administration & dosage*; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D001729:Bismuth / Q000633:toxicity; D003453:Cryptococcosis / Q000382:microbiology / Q000532:radiotherapy*; D003455:Cryptococcus neoformans / Q000187:drug effects* / Q000276:immunology; D005260:Female; D007121:Immunocompetence; D018796:Immunoconjugates / Q000008:administration & dosage / Q000627:therapeutic use*; D008168:Lung / Q000187:drug effects* / Q000382:microbiology; D051379:Mice; D008810:Mice, Inbred C57BL; D016499:Radioimmunotherapy / Q000379:methods*; D011868:Radioisotopes; D012211:Rhenium / Q000633:toxicity
chemical_list: D000908:Antibodies, Fungal; D000911:Antibodies, Monoclonal; D018796:Immunoconjugates; D011868:Radioisotopes; D012211:Rhenium; D001729:Bismuth