title: Nonfluoride caries-preventive agents: executive summary of evidence-based clinical recommendations.
abstract: BACKGROUND
  In this article, the authors present evidence-based clinical recommendations regarding the use of nonfluoride caries preventive agents. The recommendations were developed by an expert panel convened by the American Dental Association (ADA)Council on Scientific Affairs. The panel addressed several questions regarding the efficacy of nonfluoride agents in reducing the incidence of caries and arresting or reversing the progression of caries.
  
  
  METHODS
  A panel of experts convened by the ADA Council on Scientific Affairs, in collaboration with ADA Division of Science staff, conducted a MEDLINE search to identify all randomized and nonrandomized clinical studies regarding the use of non fluoride caries-preventive agents.
  
  
  RESULTS
  The panel reviewed evidence from 50 randomized controlled trials and 15 nonrandomized studies to assess the efficacy of various nonfluoride caries-preventive agents.
  
  
  CONCLUSIONS
  The panel concluded that certain nonfluoride agents may provide some benefit as adjunctive therapies in children and adults at higher risk of developing caries. These recommendations are presented as a resource for dentists to consider in the clinical decision-making process. As part of the evidence based approach to care, these clinical recommendations should be integrated with the practitioner’s professional judgment and the patient’s needs and preferences.
authors: College of Dentistry, The Ohio State University College of Dentistry, Columbus, OH, USA.
authors: Michael P
authors: MP
authors: Rethman
authors: Eugenio D
authors: ED
authors: Beltrán-Aguilar
authors: Ronald J
authors: RJ
authors: Billings
authors: Philippe P
authors: PP
authors: Hujoel
authors: Barry P
authors: BP
authors: Katz
authors: Peter
authors: P
authors: Milgrom
authors: Woosung
authors: W
authors: Sohn
authors: John W
authors: JW
authors: Stamm
authors: Gene
authors: G
authors: Watson
authors: Mark
authors: M
authors: Wolff
authors: J Tim
authors: JT
authors: Wright
authors: Domenick
authors: D
authors: Zero
authors: Krishna
authors: K
authors: Aravamudhan
authors: Julie
authors: J
authors: Frantsve-Hawley
authors: Daniel M
authors: DM
authors: Meyer
mesh_terms: D000328:Adult; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D002327:Cariostatic Agents / Q000627:therapeutic use*; D002638:Chewing Gum; D002648:Child; D002710:Chlorhexidine / Q000627:therapeutic use; D003731:Dental Caries / Q000517:prevention & control*; D003733:Dental Caries Susceptibility / Q000187:drug effects; D055094:Evidence-Based Dentistry; D006801:Humans; D013549:Sweetening Agents / Q000627:therapeutic use; D014089:Tooth Remineralization
chemical_list: D000891:Anti-Infective Agents, Local; D002327:Cariostatic Agents; D002638:Chewing Gum; D013549:Sweetening Agents; D002710:Chlorhexidine