title: Social disruption induced priming of CNS inflammatory response to Theiler's virus is dependent upon stress induced IL-6 release.
abstract: Chronic social disruption stress (SDR) exacerbates acute and chronic phase Theiler's murine encephalomyelitis virus (TMEV) infection, a mouse model of multiple sclerosis. However, the precise mechanism by which this occurs remains unknown. The present study suggests that SDR exacerbates TMEV disease course by priming virus-induced neuroinflammation. It was demonstrated that IL-1β mRNA expression increases following acute SDR; however, IL-6 mRNA expression, but not IL-1β, is upregulated in response to chronic SDR. Furthermore, this study demonstrated SDR prior to infection increases infection related central IL-6 and IL-1β mRNA expression, and administration of IL-6 neutralizing antibody during SDR reverses this increase in neuroinflammation.
authors: Dept. of Psychology, College of Liberal Arts, Texas A&M University, United States.
authors: E G
authors: EG
authors: Vichaya
authors: E E
authors: EE
authors: Young
authors: M A
authors: MA
authors: Frazier
authors: J L
authors: JL
authors: Cook
authors: C J
authors: CJ
authors: Welsh
authors: M W
authors: MW
authors: Meagher
mesh_terms: D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D018792:Encephalitis, Viral / Q000235:genetics / Q000276:immunology* / Q000473:pathology*; D015967:Gene Expression Regulation, Viral / Q000276:immunology*; D053583:Interleukin-1beta / Q000096:biosynthesis / Q000235:genetics; D015850:Interleukin-6 / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009103:Multiple Sclerosis / Q000276:immunology / Q000473:pathology / Q000821:virology; D011897:Random Allocation; D012931:Social Environment; D013315:Stress, Psychological / Q000235:genetics / Q000276:immunology* / Q000473:pathology*; D017945:Theilovirus / Q000276:immunology*; D015854:Up-Regulation / Q000235:genetics / Q000276:immunology
chemical_list: D053583:Interleukin-1beta; D015850:Interleukin-6