title: Empiric acyclovir for neonatal herpes simplex virus infection.
abstract: BACKGROUND
  Because neonatal herpes simplex virus (NHSV) infection is difficult to diagnose, there has been a move towards using more empiric acyclovir (ACV).
  
  
  OBJECTIVE
  The purpose of this study was to review the use of ACV to optimize future management of NHSV.
  
  
  METHODS
  Charts were reviewed for infants started on intravenous ACV up to day 43 of life--January 2001 through February 2007--at five hospitals in Edmonton and Calgary.
  
  
  RESULTS
  ACV was started for possible (N = 115) or proven (N = 3) herpes simplex virus (HSV) infection. Six of the infants with possible HSV infection later had proven HSV infection. Seizures (34%), hemodynamic instability (29%) and skin lesions (24%) were the most common indications for ACV. Among the 118 infants, 106 (90%) had cerebrospinal fluid obtained and 82 (69%) had at least one surface swab for HSV but 4 (3%) had no specimens submitted for HSV detection. ACV was continued for 3.9 ± 3.5 days in the infants with no proven HSV disease. Possible nephrotoxicity from ACV was recorded in 3 of these 109 infants and in none of the infants with proven HSV disease.
  
  
  CONCLUSIONS
  Clinicians in Alberta primarily consider the diagnosis of NHSV infection when confronted with a neonate with seizures, hemodynamic instability or suspicious skin lesions, but need to consider the diagnosis more often if all cases are to be treated at first presentation. They often perform incomplete investigations to rule out NHSV infection. Adverse events from ACV appear to be uncommon when the drug is used for suspected NHSV disease.
authors: Department of Pediatrics, Stollery Children's Hospital, University of Alberta, Edmonton, Canada.
authors: Christina
authors: C
authors: Vanderpluym
authors: Gerda
authors: G
authors: Tawfik
authors: Marilou
authors: M
authors: Hervas-Malo
authors: Thierry
authors: T
authors: Lacaze-Masmonteil
authors: James
authors: J
authors: Kellner
authors: Joan L
authors: JL
authors: Robinson
mesh_terms: D000212:Acyclovir / Q000009:adverse effects / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000009:adverse effects / Q000627:therapeutic use; D002170:Canada / Q000453:epidemiology; D036262:Empirical Research; D005260:Female; D005865:Gestational Age; D006561:Herpes Simplex / Q000151:congenital* / Q000188:drug therapy* / Q000453:epidemiology / Q000635:transmission; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control / Q000706:statistics & numerical data; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology; D012189:Retrospective Studies; D018139:Simplexvirus / Q000187:drug effects / Q000302:isolation & purification / Q000502:physiology
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir