title: Effect of phlorotannins from Sargassum thunbergii on blood lipids regulation in mice with high-fat diet.
abstract: On the basis of activity screening on blood lipid regulation by animal study, we chose high molecular weight phlorotannins from Sargassum thunbergii (HMPs) as a drug to explore the regulating mechanism. The results showed that HMPs could significantly decrease TC and TG levels (p < 0.05), and very significantly decrease LDL-C level (p < 0.01). Results of a hypocholesterolemic mechanism study showed that HMPs could obviously increase liver LDL-R level (p < 0.05), but the fact that they failed to block the synthesis of HMG-CoA reductase excludes a relevant influence on cellular cholesterol biosynthesis. We propose that HMPs from Sargassum thunbergii have a profound hypocholesterolemic effect and the mechanism relies mainly on the increase of LDL-R level in liver.
authors: Department of Biology, Qingdao University, Qingdao 266071, P.R. China. yuxiw729@163.com
authors: Yuxi
authors: Y
authors: Wei
authors: Chuanjin
authors: C
authors: Xu
authors: Qi
authors: Q
authors: Liu
authors: Huihui
authors: H
authors: Xiao
authors: Aiyun
authors: A
authors: Zhao
authors: Yingfen
authors: Y
authors: Hu
authors: Lei
authors: L
authors: Liu
authors: Ling
authors: L
authors: Zhao
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000737:chemistry / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D059305:Diet, High-Fat / Q000009:adverse effects*; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D011973:Receptors, LDL / Q000378:metabolism; D044647:Sargassum / Q000737:chemistry*; D013634:Tannins / Q000737:chemistry* / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
chemical_list: D000924:Anticholesteremic Agents; D008078:Cholesterol, LDL; D008055:Lipids; D011973:Receptors, LDL; D013634:Tannins; D014280:Triglycerides; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases