title: C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects.
abstract: BACKGROUND
  Chronic low-grade inflammation, characterized by elevated plasma levels of C-reactive protein (CRP), has been inversely associated with dispositional optimism. Using a Mendelian randomization design, this study explores whether CRP haplotypes that determine CRP plasma levels are also associated with dispositional optimism.
  
  
  METHODS
  In a sample of 1,084 community-dwelling subjects (aged 60-85 years) from three cohort studies (Arnhem Elderly Study, n = 426; Leiden Longevity Study, n = 355; Zutphen Elderly Study, n = 303), six CRP polymorphisms (rs2808628, rs2808630, rs1205, rs1800947, rs1417938, and rs3091244) coding for five common haplotypes were genotyped. The association of CRP haplotypes with CRP plasma levels and dispositional optimism was analyzed using multivariable linear regression models. Subanalyses were stratified by body mass index (BMI ≥25 kg/m(2)).
  
  
  RESULTS
  CRP haplotypes determined CRP plasma levels (adjusted β = 0.094, p < 0.001). In the whole group, no association was found between CRP haplotypes and dispositional optimism scores (adjusted β = -0.02, p = 0.45). In BMI strata, CRP haplotypes were associated with increasing levels of plasma CRP levels (adjusted β = 0.112; p = 0.002) and lower dispositional optimism levels (adjusted β = -0.068; p = 0.03) in the obese group only.
  
  
  CONCLUSIONS
  These results suggest that genetically increased CRP levels are involved in low dispositional optimism, but only in case of obesity.
authors: Department of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands. N.Rius_Ottenheim@lumc.nl
authors: Nathaly
authors: N
authors: Rius-Ottenheim
authors: Anton J M
authors: AJ
authors: de Craen
authors: Johanna M
authors: JM
authors: Geleijnse
authors: P Eline
authors: PE
authors: Slagboom
authors: Daan
authors: D
authors: Kromhout
authors: Roos C
authors: RC
authors: van der Mast
authors: Frans G
authors: FG
authors: Zitman
authors: Rudi G
authors: RG
authors: Westendorp
authors: Erik J
authors: EJ
authors: Giltay
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D001290:Attitude; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D015331:Cohort Studies; D005260:Female; D006239:Haplotypes; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism*; D012044:Regression Analysis
chemical_list: D002097:C-Reactive Protein