title: Fasciculols H and I, two lanostane derivatives from Chinese mushroom Naematoloma fasciculare.
abstract: Two new highly oxygenated fasciculol-type lanostane derivatives, fasciculols H and I (1 and 2, resp.), together with five known compounds, 3-7, were isolated from the fruiting bodies of the Chinese toxic mushroom Naematoloma fasciculare. Their structures were elucidated on the basis of spectroscopic analyses including 2D-NMR (HMBC, HSQC, NOESY, (1)H,(1)H-COSY). Compounds 5-7 were identified for the first time in this mushroom. Compounds 1, 3, 4, and 5 were evaluated for inhibitory activity against human glioma cell line U87 and nuclear factor-κB.
authors: Research Centre for Natural Medicinal Chemistry, College of Science, Northwest A&F University, Yangling 712100, P. R. China.
authors: Xin-Wei
authors: XW
authors: Shi
authors: Xiao-Jun
authors: XJ
authors: Li
authors: Jin-Ming
authors: JM
authors: Gao
authors: Xing-Chang
authors: XC
authors: Zhang
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D018906:Antineoplastic Agents, Alkylating; D045744:Cell Line, Tumor; D016543:Central Nervous System Neoplasms / Q000188:drug therapy / Q000473:pathology; D004354:Drug Screening Assays, Antitumor; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D005910:Glioma / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D052002:NF-kappa B p50 Subunit / Q000037:antagonists & inhibitors; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D052002:NF-kappa B p50 Subunit; C489548:NFKB1 protein, human; D014315:Triterpenes; C570502:fasciculol H; C570501:fasciculol I