title: MG-ADL: still a relevant outcome measure.
abstract: BACKGROUND
  The aim of this analysis was to examine the performance of the Myasthenia Gravis-specific Activities of Daily Living scale (MG-ADL) during a multicenter scale validation study.
  
  
  METHODS
  Consecutive MG patients were assessed with several MG outcome measures, including the MG-ADL. Statistical tests included descriptive analysis, Pearson correlation, and sensitivity/specificity.
  
  
  RESULTS
  Eighty-seven patients completed the MG-ADL, MG Composite (MGC), and MG 15-item Quality of Life scale (MG-QOL15) on the first visit, and 76 returned for the second visit. At the first visit, there was a strong positive correlation between MG-ADL and MGC (r = 0.85, P < 0.0001) and MG-QOL15 (r = 0.76, P < 0.0001). Correlation of the delta MG-ADL score and physician impression of change between the visits was strong (r = 0.70, P < 0.0001). A 2-point improvement in the MG-ADL best predicted clinical improvement. Test-retest analysis demonstrated a high reliability coefficient.
  
  
  CONCLUSIONS
  The MG-ADL correlates strongly with newer, validated MG outcome measures. A 2-point improvement in the MG-ADL indicates clinical improvement. The MG-ADL is useful as a research tool and in routine clinical management.
authors: Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
authors: Srikanth
authors: S
authors: Muppidi
authors: Gil I
authors: GI
authors: Wolfe
authors: Mark
authors: M
authors: Conaway
authors: Ted M
authors: TM
authors: Burns
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000175:diagnosis* / Q000523:psychology; D017063:Outcome Assessment, Health Care / Q000379:methods* / Q000592:standards*; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires / Q000592:standards*