title: A novel anti-peroxiredoxin autoantibody in patients with Kawasaki disease.
abstract: Antibodies to the anti-oxidative peroxiredoxin (Prx) enzymes occur in both systemic autoimmune disease and vasculitis in adulthood. Because increased oxidative stress induces vasculitis in Kawasaki disease (KD), autoimmunity to Prxs in patients with KD was investigated. The presence of antibodies to Prx 1, 2 and 4 was analyzed by ELISA and Western blot. Of 30 patients with KD, 13 (43.3%) possessed antibodies to Prx 2, whereas these antibodies were present in only 1 of 10 patients (10.0%) with sepsis (4 with purulent meningitis and 6 with septicemia). In contrast, antibodies to Prx 1 and 4 were not detected in either group. There was no significant correlation among the titers of the three antibodies. Clinical parameters were compared between anti-Prx 2-positive and -negative patients. The presence of anti-Prx 2 antibodies correlated with a longer period of fever and poor response to high-dose γ-globulin therapy in patients with KD. Anti-Prx 2-positive patients had significantly greater excretion of urinary 8-isoprostaglandin than did anti-Prx 2-negative patients. These results provide the first evidence for an antibody to Prx 2 in patients with KD. They also suggest that this antibody might serve as a marker of disease severity and be involved in the pathophysiology of vasculitis in some patients with KD.
authors: Department of Pediatrics, Kochi Medical School, Kochi University, Kochi, Japan. fujiedam@kochi-u.ac.jp
authors: Mikiya
authors: M
authors: Fujieda
authors: Rie
authors: R
authors: Karasawa
authors: Hisashi
authors: H
authors: Takasugi
authors: Masaki
authors: M
authors: Yamamoto
authors: Koichi
authors: K
authors: Kataoka
authors: Kazuo
authors: K
authors: Yudoh
authors: Tomohiro
authors: T
authors: Kato
authors: Shoichi
authors: S
authors: Ozaki
authors: Hiroshi
authors: H
authors: Wakiguchi
mesh_terms: D000975:Antioxidants; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D015415:Biomarkers / Q000652:urine; D015153:Blotting, Western; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood / Q000276:immunology* / Q000652:urine; D018384:Oxidative Stress; D054464:Peroxiredoxins / Q000097:blood / Q000276:immunology*; D015995:Prevalence; D011453:Prostaglandins / Q000652:urine; D012720:Severity of Illness Index; D005719:gamma-Globulins / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D001323:Autoantibodies; D015415:Biomarkers; D011453:Prostaglandins; D005719:gamma-Globulins; D054464:Peroxiredoxins