title: RIG-I like receptors in antiviral immunity and therapeutic applications.
abstract: The RNA helicase family of RIG-I-like receptors (RLRs) is a key component of host defense mechanisms responsible for detecting viruses and triggering innate immune signaling cascades to control viral replication and dissemination. As cytoplasm-based sensors, RLRs recognize foreign RNA in the cell and activate a cascade of antiviral responses including the induction of type I interferons, inflammasome activation, and expression of proinflammatory cytokines and chemokines. This review provides a brief overview of RLR function, ligand interactions, and downstream signaling events with an expanded discussion on the therapeutic potential of targeting RLRs for immune stimulation and treatment of virus infection.
authors: Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA. rireton@u.washington.edu
authors: Reneé C
authors: RC
authors: Ireton
authors: Michael
authors: M
authors: Gale
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use; D053487:DEAD-box RNA Helicases / Q000235:genetics / Q000276:immunology*; D020536:Enzyme Activators / Q000627:therapeutic use; D006801:Humans; D007113:Immunity, Innate; D014777:Virus Diseases / Q000188:drug therapy / Q000201:enzymology* / Q000276:immunology* / Q000821:virology; D018406:Virus Physiological Phenomena; D014780:Viruses / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D020536:Enzyme Activators; D053487:DEAD-box RNA Helicases