title: An enhanced β turn in water.
abstract: Aiming to design short linear peptides featuring strong intramolecular hydrogen bonds in water, a series of tetrapeptides based on the sequence Ac-Ala-Pro-Ala-Ala-NH(2) containing all possible combinations of L- and D-amino acids was synthesized. A regiospecific combination of heterochiral residues (DDLL or its mirror image LLDD) can be used to increase turn formation and stability within short peptides in water.
authors: Center for Advanced Drug Research (CADRE), SRI International , 140 Research Drive, Harrisonburg, Virginia 22802, USA.
authors: Martha G
authors: MG
authors: Bomar
authors: Benben
authors: B
authors: Song
authors: Patrick
authors: P
authors: Kibler
authors: Krishna
authors: K
authors: Kodukula
authors: Amit K
authors: AK
authors: Galande
mesh_terms: D000577:Amides / Q000737:chemistry; D006860:Hydrogen Bonding; D015394:Molecular Structure; D014867:Water / Q000737:chemistry*
chemical_list: D000577:Amides; D014867:Water