title: The combination of Ezetimibe and Statin: a new treatment for hypercholesterolemia.
abstract: The combination of Simvastatin and Ezetimibe allows dual inhibition of both cholesterol production and absorption. This treatment approach allows achieving same low serum cholesterol levels with the administration of much lower doses of statins. This should reduce side effects, compared to statin only therapy, enabling more patients to achieve their LDL cholesterol treatment goals. With ezetimibe/simvastatin therapy, reductions of about 60% from baseline in LDL cholesterol have been shown. Concomitant improvement in other lipid fractions have also been demonstrated. The ezetimibe/simvastatin combination has been well tolerated, with a safety profile similar to that of statin therapy. This article will review clinical experience with ezetimibe/simvastatin combination, commenting upon its place and potential value in the prevention of cardiovascular disease.
authors: Section on Cardiovascular Diseases, Department of Experimental and Applied Medicine, University of Brescia - Italy.
authors: Savina
authors: S
authors: Nodari
authors: Patrizia
authors: P
authors: Rocca
authors: Alberto
authors: A
authors: Saporetti
authors: Luca
authors: L
authors: Bettari
authors: Anna Lucia
authors: AL
authors: Foresti
authors: Elena
authors: E
authors: Tanghetti
authors: Marco
authors: M
authors: Metra
authors: Livio
authors: L
authors: Dei Cas