title: [Research progress of heterotopic ossification pathogenesis].
abstract: OBJECTIVE
  To review the research progress of heterotopic ossification (HO) pathogenesis.
  
  
  METHODS
  Recent articles about HO including the risk factors and pathogenesis were reviewed and comprehensively analyzed.
  
  
  RESULTS
  The pathogenesis of HO is not completely understood, but the extracellular factors, signaling pathways, and transcription factors in the pathogenesis of HO are understood deeply, such as bone morphogenic protein, Smad signaling, and core binding factor alpha1/runt-related transcription factor 2, which are probably involved in HO. Furthermore, some related microRNAs are also probably involved in HO.
  
  
  CONCLUSIONS
  The pathogenesis of HO should be further investigated so as to lay a foundation for preventing and treating HO.
authors: Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu Sichuan 610041, PR China.
authors: Xing
authors: X
authors: Rong
authors: Qingquan
authors: Q
authors: Kong
mesh_terms: D050659:Core Binding Factor Alpha 1 Subunit / Q000378:metabolism; D035683:MicroRNAs; D009999:Ossification, Heterotopic / Q000378:metabolism / Q000473:pathology*; D012307:Risk Factors
chemical_list: D050659:Core Binding Factor Alpha 1 Subunit; D035683:MicroRNAs