title: The effects of fasudil on the permeability of the rat blood-brain barrier and blood-spinal cord barrier following experimental autoimmune encephalomyelitis.
abstract: Dysfunction of the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) is a primary characteristic of multiple sclerosis (MS). We evaluated the protective effects of fasudil, a selective ROCK inhibitor, in a model of experimental autoimmune encephalomyelitis (EAE) that was induced by guinea-pig spinal cord. In addition, we studied the effects of fasudil on BBB and BSCB permeability. We found that fasudil partly alleviated EAE-dependent damage by decreasing BBB and BSCB permeability. These results provide rationale for the development of selective inhibitors of Rho kinase as a novel therapy for MS.
authors: Department of Neurology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors: X N
authors: XN
authors: Huang
authors: J
authors: J
authors: Fu
authors: W Z
authors: WZ
authors: Wang
mesh_terms: D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects* / Q000201:enzymology / Q000503:physiopathology; D002463:Cell Membrane Permeability / Q000187:drug effects* / Q000502:physiology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000503:physiopathology* / Q000517:prevention & control*; D005260:Female; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D008565:Membrane Proteins / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D009103:Multiple Sclerosis / Q000276:immunology / Q000503:physiopathology / Q000517:prevention & control; D062793:Occludin; D010865:Pilot Projects; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D011917:Rats, Inbred Lew; D015398:Signal Transduction / Q000187:drug effects / Q000276:immunology; D013116:Spinal Cord / Q000098:blood supply* / Q000201:enzymology / Q000276:immunology*; D054460:rho-Associated Kinases / Q000037:antagonists & inhibitors / Q000096:biosynthesis
chemical_list: D007527:Isoenzymes; D008565:Membrane Proteins; D062793:Occludin; C568987:Ocln protein, rat; D047428:Protein Kinase Inhibitors; D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D054460:rho-Associated Kinases; C049347:fasudil