title: Phenols with anti-HIV activity from Daphne acutiloba.
abstract: The present paper describes the study of the phytochemical properties and anti-HIV activity of the phenolic isolates of the plateau medicinal plant Daphne acutiloba Rehd. (Thymelaeceae). Two new lignans named daphnenin (1) and daphnetone (2), along with 11 known ones, were isolated, and their structures were elucidated by 1D and 2DNMR spectroscopy aswell as HR‑ESI‑MS. In the anti-HIV activity study, daphnenin (1) and caffeic acid n-octadecyl ester (13) showed definite anti-HIVactivity with EC(50) values of 0.39 and 0.16 μg/mL, respectively.
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
authors: Sheng Zhuo
authors: SZ
authors: Huang
authors: Xing Jie
authors: XJ
authors: Zhang
authors: Xing Yao
authors: XY
authors: Li
authors: He Zhong
authors: HZ
authors: Jiang
authors: Qing Yun
authors: QY
authors: Ma
authors: Peng Cheng
authors: PC
authors: Wang
authors: Yu Qing
authors: YQ
authors: Liu
authors: Jiang Miao
authors: JM
authors: Hu
authors: Yong Tang
authors: YT
authors: Zheng
authors: Jun
authors: J
authors: Zhou
authors: You Xing
authors: YX
authors: Zhao
mesh_terms: D044966:Anti-Retroviral Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002109:Caffeic Acids / Q000302:isolation & purification / Q000494:pharmacology*; D032364:Daphne / Q000737:chemistry*; D015497:HIV-1 / Q000187:drug effects*; D017705:Lignans / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D044966:Anti-Retroviral Agents; D002109:Caffeic Acids; D017705:Lignans; D010936:Plant Extracts; C572966:caffeic acid n-octadecyl ester; C572965:daphnenin; C572964:daphnetone