title: Nicotine influences the motor performance of immature rats in two different sensorimotor tasks.
abstract: The aim of this study was to assess the effect of nicotine on motor             performance of immature (12-day-old) rats. We used two sensorimotor tasks             (surface righting response and negative geotaxis test) to evaluate the influence of             nicotine on animal's motor activity in course of 24 hours. Animals were treated             intraperitoneally with two different nicotine doses (0.5 mg/kg and 1.0 mg/kg)             and tested in four sessions (1 minute, 10 minutes, 1 hour and 24 hours after the             injection). We concluded that nicotine significantly influences the motor behaviour             in 12-day-old rats and this effect is dose dependent.
authors: Institute of Physiology, Charles University in Prague, Prague, Czech Republic. vladimir.riljak@lf1.cuni.cz
authors: V
authors: V
authors: Riljak
authors: D
authors: D
authors: Marešová
authors: A
authors: A
authors: Dohnalová
authors: J
authors: J
authors: Pokorný
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D009949:Orientation / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D057897:Reflex, Righting / Q000187:drug effects*
chemical_list: D009538:Nicotine