title: Canomad presenting without ophthalmoplegia and responding to intravenous immunoglobulin.
abstract: The acronym CANOMAD encompasses chronic ataxic neuropathy combined with ophthalmoplegia, M protein, cold agglutinins, and anti-disialosyl antibodies.Herein we describe 2 patients presenting with progressive ataxic neuropathy who only developed ophthalmoplegia after a significant delay post-presentation, which in 1 case had features indicative of brainstem dysfunction. Both patients were found to have an IgM paraprotein and anti-disialosyl antibodies. They responded to treatment with intravenous immunoglobulin, thus illustrating the importance of diagnosing this condition.
authors: Portsmouth Hospital NHS Trust, Portsmouth, UK.
authors: Cheryl
authors: C
authors: Kam
authors: Michelle S
authors: MS
authors: Balaratnam
authors: Alistair
authors: A
authors: Purves
authors: Kerry R
authors: KR
authors: Mills
authors: Paul
authors: P
authors: Riordan-Eva
authors: Steve
authors: S
authors: Pollock
authors: Istvan
authors: I
authors: Bodi
authors: Neil A R
authors: NA
authors: Munro
authors: David L H
authors: DL
authors: Bennett
mesh_terms: D000328:Adult; D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000175:diagnosis* / Q000188:drug therapy* / Q000503:physiopathology; D001259:Ataxia / Q000175:diagnosis* / Q000188:drug therapy* / Q000503:physiopathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D008297:Male; D009886:Ophthalmoplegia / Q000175:diagnosis* / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D016756:Immunoglobulins, Intravenous