title: Plasma phospholipid fatty acid concentrations and risk of gastric adenocarcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST).
abstract: BACKGROUND
  Epidemiologic data suggest that diet is a risk factor in the etiology of gastric cancer. However, the role of dietary fatty acids, a modifiable risk factor, remains relatively unexplored.
  
  
  OBJECTIVE
  The objective of this study was to determine the association of plasma phospholipid fatty acid concentrations, as biomarkers of exogenous and endogenously derived fatty acids, with the risk of gastric adenocarcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition-Europe Gastric Cancer (EPIC-EURGAST).
  
  
  METHODS
  Fatty acids were measured by gas chromatography in prediagnostic plasma phospholipids from 238 cases matched to 626 controls by age, sex, study center, and date of blood donation. Conditional logistic regression models adjusted for Helicobacter pylori infection status, BMI, smoking, physical activity, education, and energy intake were used to estimate relative cancer risks.
  
  
  RESULTS
  Positive risk associations for gastric cancer were observed in the highest compared with the lowest quartiles of plasma oleic acid (OR: 1.72; 95% CI: 1.01, 2.94), di-homo-γ-linolenic acid (OR: 1.92; 95% CI: 1.10, 3.35), α-linolenic acid (OR: 3.20; 95% CI: 1.70, 6.06), and the ratio of MUFAs to saturated fatty acids, as an indicator of stearoyl-CoA desaturase-1 enzyme activity (OR: 1.40; 95% CI: 0.81, 2.43). An inverse risk association was observed with the ratio of linoleic to α-linolenic acid (OR: 0.37; 95% CI: 0.20, 0.66).
  
  
  CONCLUSIONS
  These data suggest that a specific prediagnostic plasma phospholipid fatty acid profile, characterized mainly by high concentrations of oleic acid, α-linolenic acid, and di-homo-γ-linolenic acid, which presumably reflect both a complex dietary pattern and altered fatty acid metabolism, may be related to increased gastric cancer risk.
authors: Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France. chajesv@visitors.iarc.fr
authors: Véronique
authors: V
authors: Chajès
authors: Mazda
authors: M
authors: Jenab
authors: Isabelle
authors: I
authors: Romieu
authors: Pietro
authors: P
authors: Ferrari
authors: Christina C
authors: CC
authors: Dahm
authors: Kim
authors: K
authors: Overvad
authors: Rikke
authors: R
authors: Egeberg
authors: Anne
authors: A
authors: Tjønneland
authors: Françoise
authors: F
authors: Clavel-Chapelon
authors: Marie-Christine
authors: MC
authors: Boutron-Ruault
authors: Pierre
authors: P
authors: Engel
authors: Birgit
authors: B
authors: Teucher
authors: Rudolf
authors: R
authors: Kaaks
authors: Anna
authors: A
authors: Floegel
authors: Heiner
authors: H
authors: Boeing
authors: Antonia
authors: A
authors: Trichopoulou
authors: Vardis
authors: V
authors: Dilis
authors: Tina
authors: T
authors: Karapetyan
authors: Amalia
authors: A
authors: Mattiello
authors: Rosario
authors: R
authors: Tumino
authors: Sara
authors: S
authors: Grioni
authors: Domenico
authors: D
authors: Palli
authors: Paolo
authors: P
authors: Vineis
authors: H Bas
authors: HB
authors: Bueno-de-Mesquita
authors: Mattijs E
authors: ME
authors: Numans
authors: Petra H M
authors: PH
authors: Peeters
authors: Eiliv
authors: E
authors: Lund
authors: Carmen
authors: C
authors: Navarro
authors: Jose Ramón
authors: JR
authors: Quirós
authors: Emilio
authors: E
authors: Sánchez-Cantalejo
authors: Aurelio Barricarte
authors: AB
authors: Gurrea
authors: Miren
authors: M
authors: Dorronsoro
authors: Sara
authors: S
authors: Regnér
authors: Emily
authors: E
authors: Sonestedt
authors: Elisabet
authors: E
authors: Wirfält
authors: Kay-Tee
authors: KT
authors: Khaw
authors: Nick
authors: N
authors: Wareham
authors: Naomi E
authors: NE
authors: Allen
authors: Francesca L
authors: FL
authors: Crowe
authors: Sabina
authors: S
authors: Rinaldi
authors: Nadia
authors: N
authors: Slimani
authors: Fatima
authors: F
authors: Carneiro
authors: Elio
authors: E
authors: Riboli
authors: Carlos A
authors: CA
authors: González
mesh_terms: D000230:Adenocarcinoma / Q000097:blood* / Q000453:epidemiology; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015331:Cohort Studies; D005060:Europe / Q000453:epidemiology; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood*; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000097:blood* / Q000453:epidemiology; D011795:Surveys and Questionnaires
chemical_list: D005227:Fatty Acids; D010743:Phospholipids