title: Smear cytology findings of large cell neuroendocrine carcinoma of the uterine cervix.
abstract: Large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is a rare tumor. Moreover, there are only three reports to date that have focused on the cytologic findings of cervical LCNEC. We report the case of a 59-year-old Japanese woman with cervical LCNEC combined with small cell carcinoma (SmCC). Cytologic specimens from the uterine cervix demonstrated large cells with coarse chromatin and prominent nucleoli. Frequent mitotic figures were also observed. Curettage of the uterine endometrium revealed an endometrioid adenocarcinoma with squamous differentiation; i.e., an adenoacanthoma. Histologic examination of surgically resected uterine cervical tissue revealed LCNEC with minor foci of SmCC. Neuroendocrine differentiation in LCNEC was confirmed by immunohistochemistry for synaptophysin and CD56. Cytotechnologists or pathologists need to consider a differential diagnosis of LCNEC while examining cervical cytologic specimens; therefore, it is important to correctly identify the cytologic characteristics of this tumor.
authors: Department of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi, Japan. kurochankochi@yahoo.co.jp
authors: Naoto
authors: N
authors: Kuroda
authors: Yukari
authors: Y
authors: Wada
authors: Kaori
authors: K
authors: Inoue
authors: Masahiko
authors: M
authors: Ohara
authors: Keiko
authors: K
authors: Mizuno
authors: Makoto
authors: M
authors: Toi
authors: Azusa
authors: A
authors: Tanaka
authors: Yoji
authors: Y
authors: Wani
authors: Hiroyuki
authors: H
authors: Yanai
mesh_terms: D049309:Acanthoma / Q000378:metabolism / Q000473:pathology*; D019002:CD56 Antigen / Q000378:metabolism; D018269:Carcinoma, Endometrioid / Q000378:metabolism / Q000473:pathology*; D018278:Carcinoma, Neuroendocrine / Q000378:metabolism / Q000473:pathology*; D018288:Carcinoma, Small Cell / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D016708:Synaptophysin / Q000378:metabolism; D002583:Uterine Cervical Neoplasms / Q000378:metabolism / Q000473:pathology*; D014626:Vaginal Smears / Q000379:methods*
chemical_list: D019002:CD56 Antigen; D016708:Synaptophysin