title: Sesquiterpenoids from Inula racemosa Hook. f. inhibit nitric oxide production.
abstract: A novel trinorsesquiterpene (1), three new (2-4), and 10 known sesquiterpenes were isolated from the roots of Inula racemosa Hook. f. The structures and absolute configurations of the new sesquiterpenes were elucidated by extensive spectroscopic and computational methods. All compounds were evaluated for their inhibition of LPS-induced nitric oxide production in RAW264.7 macrophages, and the results indicated that compounds 9, 12, and 13 moderately inhibited nitric oxide production with IC₅₀ values of 7.39 ± 0.36, 6.35 ± 0.26, and 5.39 ± 0.18 µM, respectively.
authors: School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
authors: Shou-De
authors: SD
authors: Zhang
authors: Jiang-Jiang
authors: JJ
authors: Qin
authors: Hui-Zi
authors: HZ
authors: Jin
authors: Yin-Hua
authors: YH
authors: Yin
authors: Hong-Lin
authors: HL
authors: Li
authors: Xian-Wen
authors: XW
authors: Yang
authors: Xia
authors: X
authors: Li
authors: Lei
authors: L
authors: Shan
authors: Wei-Dong
authors: WD
authors: Zhang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D038143:Inula / Q000737:chemistry*; D008070:Lipopolysaccharides; D008264:Macrophages / Q000187:drug effects*; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D008070:Lipopolysaccharides; D010936:Plant Extracts; D012717:Sesquiterpenes; D009569:Nitric Oxide