title: Thermosensitive dendrimer formulation for drug delivery at physiologically relevant temperatures.
abstract: A simple and versatile dendrimer based platform to deliver therapeutic agents at temperatures within the physiological range, is reported. Lipoic acid conjugated at the periphery of the thermosensitive dendrimer formulations undergoes slow and sustained release at 37-42 °C, and rescues the cells from oxidative stress and a pro-inflammatory endotoxic agent.
authors: Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, Quebec, H3A 2K6, Canada.
authors: Annie
authors: A
authors: Castonguay
authors: Eleanor
authors: E
authors: Wilson
authors: Noura
authors: N
authors: Al-Hajaj
authors: Laurène
authors: L
authors: Petitjean
authors: Julie
authors: J
authors: Paoletti
authors: Dusica
authors: D
authors: Maysinger
authors: Ashok
authors: A
authors: Kakkar
mesh_terms: D000114:Acetylene / Q000737:chemistry; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001386:Azides / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D057930:Click Chemistry; D050091:Dendrimers / Q000737:chemistry / Q000494:pharmacology*; D016503:Drug Delivery Systems; D005663:Furans / Q000737:chemistry; D006861:Hydrogen Peroxide / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008301:Maleimides / Q000737:chemistry; D017628:Microglia / Q000187:drug effects / Q000378:metabolism; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D016877:Oxidants / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects*; D010269:Paraquat / Q000494:pharmacology; D013696:Temperature; D008063:Thioctic Acid / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D001386:Azides; D050091:Dendrimers; D005663:Furans; D008070:Lipopolysaccharides; D008301:Maleimides; D016877:Oxidants; C043592:maleimide; D008063:Thioctic Acid; D006861:Hydrogen Peroxide; D000114:Acetylene; D010269:Paraquat