title: A(H5N1) Virus Evolution in South East Asia.
abstract: Highly Pathogenic Avian Influenza (HPAI) H5N1 virus is an ongoing public health and socio-economic challenge, particularly in South East Asia. H5N1 is now endemic in poultry in many countries, and represents a major pandemic threat. Here, we describe the evolution of H5N1 virus in South East Asia, the reassortment events leading to high genetic diversity in the region, and factors responsible for virus spread. The virus has evolved with genetic variations affecting virulence, drug-resistance, and adaptation to new host species. The constant surveillance of these changes is of primary importance in the global efforts of the scientific community.
authors: Institut Pasteur du Cambodge, Virology Unit, 5 Monivong boulevard, PO Box 983, Phnom Penh, Cambodia; E-Mails:  naughtin@pasteur-kh.org  (M.J.N.);  hsviseth@pasteur-kh.org  (S.V.H.).
authors: Ramona Alikiiteaga
authors: RA
authors: Gutiérrez
authors: Monica Jane
authors: MJ
authors: Naughtin
authors: Srey Viseth
authors: SV
authors: Horm
authors: Sorn
authors: S
authors: San
authors: Philippe
authors: P
authors: Buchy