title: Humoral immune response in goats immunised with cathepsin L1, peroxiredoxin and Sm14 antigen and experimentally challenged with Fasciola hepatica.
abstract: The humoral immune response was analysed in goats immunised with FhCL1, FhPrx, Sm14, and experimentally challenged with Fasciola hepatica. All immunised animals developed significant levels of anti-fluke specific antibodies and those immunised with FhCL1 showed the highest antibody titre. After experimental infection, an increase in the antibody level was detected only in goats immunised with FhCL1. In the adjuvant-control animals, the experimental challenge induced significant production of specific antibodies against FhCL1, FhPrx and Sm14. While liver fluke specific humoral responses were seen in all groups, no significant protection in any of the vaccinated groups was found.
authors: Animal Health Department (Parasitology and Parasitic Diseases), Faculty of Veterinary Medicine, University of Córdoba, Campus de Rabanales, Ctra. Madrid-Cádiz, km 396, 14014 Córdoba, Spain. h12bupel@uco.es
authors: L
authors: L
authors: Buffoni
authors: F J
authors: FJ
authors: Martínez-Moreno
authors: R
authors: R
authors: Zafra
authors: R E
authors: RE
authors: Mendes
authors: A
authors: A
authors: Pérez-Écija
authors: M
authors: M
authors: Sekiya
authors: G
authors: G
authors: Mulcahy
authors: J
authors: J
authors: Pérez
authors: A
authors: A
authors: Martínez-Moreno
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D000947:Antigens, Helminth / Q000276:immunology*; D002403:Cathepsins / Q000276:immunology*; D005210:Fasciola hepatica; D005211:Fascioliasis / Q000517:prevention & control / Q000662:veterinary*; D015511:Goat Diseases / Q000517:prevention & control*; D006041:Goats; D056724:Immunity, Humoral; D007074:Immunoglobulin G / Q000097:blood / Q000145:classification; D054464:Peroxiredoxins / Q000276:immunology; D014612:Vaccines / Q000276:immunology*
chemical_list: D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D007074:Immunoglobulin G; D014612:Vaccines; D054464:Peroxiredoxins; D002403:Cathepsins; C509464:cathepsin L1, Fasciola hepatica