title: The gingiva contains leptin and leptin receptor in health and disease.
abstract: The presence of leptin (OB) and soluble OB receptor (s-OB-R) in gingival tissue extract and gingival crevicular fluid has led the studies investigating the relationship between OB and periodontal diseases. This study aims to investigate the levels of OB and s-OB-R in serum and their presence in gingiva of healthy controls (HC), gingivitis (G), aggressive periodontitis (AP), and chronic periodontitis (CP) patients; and whether correlations exist between clinical and serum parameters, OB and s-OB-R. Seventy-seven subjects [HC (n = 20), G (n = 20), CP (n = 21), and AP (n = 16)] were included in this study. After the clinical periodontal parameter recordings and venous blood sampling, gingival tissues obtained. Serum parameters' levels determined with enzyme linked immune sorbent assay; and OB and OB-R in gingiva immunohistochemically. No significant differences were observed regarding the serum parameters [high sensitivity C-reactive protein (hs-CRP), lipids, OB, and s-OB-R] when the groups were compared (P > 0.0125). The serum OB has positive correlations with hs-CRP in the G group (P < 0.05), and s-OB-R has presented significant negative correlations with BOP in HC group (P < 0.05), with hs-CRP in G (P < 0.05) and AP groups (P < 0.05). The positive correlations were observed between the serum OB and HDL and body mass index in the CP group (P < 0.05). In all of the tissue samples of all groups, there was positive OB and OB-R immunoreactivity in the gingival epithelium. The gingival tissues contain both OB and OB-R. The serum levels of OB and s-OB-R do not vary between patients and with different periodontal conditions.
authors: Department of Periodontology, Faculty of Dentistry, Süleyman Demirel University, Isparta, Turkey. zuhalyetkin@yahoo.com
authors: Zuhal Yetkin
authors: ZY
authors: Ay
authors: F Yeşim
authors: FY
authors: Kırzıoğlu
authors: Mine Oztürk
authors: MO
authors: Tonguç
authors: Recep
authors: R
authors: Sütçü
authors: Nilgün
authors: N
authors: Kapucuoğlu
mesh_terms: D000328:Adult; D010520:Aggressive Periodontitis / Q000097:blood / Q000378:metabolism*; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D055113:Chronic Periodontitis / Q000097:blood / Q000378:metabolism*; D003774:Dental Plaque Index; D004848:Epithelium / Q000737:chemistry; D005260:Female; D005881:Gingiva / Q000737:chemistry*; D005884:Gingival Hemorrhage / Q000097:blood / Q000378:metabolism; D005891:Gingivitis / Q000097:blood / Q000378:metabolism*; D006801:Humans; D020738:Leptin / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000097:blood / Q000378:metabolism; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000097:blood / Q000378:metabolism; D054411:Receptors, Leptin / Q000032:analysis* / Q000097:blood; D014280:Triglycerides / Q000032:analysis / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; C515448:LEPR protein, human; D020738:Leptin; D054411:Receptors, Leptin; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol