title: Gliomatosis cerebelli in a Saint Bernard dog.
abstract: A 6-year-old, neutered male Saint Bernard dog was presented with a 1-month history of ataxia, hypermetria and head tilt. High-field magnetic resonance imaging revealed a mass in the cerebellar vermis. During necropsy examination, a cream-coloured irregular area was observed in the cerebellar white matter. Microscopically, the mass comprised a diffuse neoplastic proliferation of spindle cells with oval pleomorphic nuclei in the white and grey matter of the cerebellum and pons and in the subpial area. Neoplastic infiltration was not found in the cerebrum. Immunohistochemistry revealed that the neoplastic cells were positive for vimentin and partially positive for glial fibrillary acidic protein. Based on these findings, the neoplastic lesion was diagnosed as gliomatosis cerebelli, without involvement of the cerebrum.
authors: Department of Veterinary Pathology, Faculty of Agriculture, Iwate University, Japan.
authors: H
authors: H
authors: Fukuoka
authors: J
authors: J
authors: Sasaki
authors: H
authors: H
authors: Kamishina
authors: R
authors: R
authors: Sato
authors: J
authors: J
authors: Yasuda
authors: M
authors: M
authors: Katayama
authors: K
authors: K
authors: Tohyama
authors: M
authors: M
authors: Ohshida
authors: M
authors: M
authors: Goryo
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D002528:Cerebellar Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000662:veterinary*; D002531:Cerebellum / Q000473:pathology; D004285:Dogs; D017809:Fatal Outcome; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D007150:Immunohistochemistry / Q000662:veterinary; D008279:Magnetic Resonance Imaging / Q000662:veterinary; D008297:Male; D018302:Neoplasms, Neuroepithelial / Q000175:diagnosis / Q000378:metabolism / Q000662:veterinary*; D014746:Vimentin / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D005904:Glial Fibrillary Acidic Protein; D014746:Vimentin