title: Fever and antipyresis in infection.
abstract: Fever is an important mechanism of intrinsic resistance against infectious disease. A variety of studies point to a potential detrimental effect of temperature lowering in infectious disorders, but high-quality evidence from randomised controlled trials is lacking. In ambulatory care settings, we need to know whether antipyretics influence the severity and duration of illnesses and, in critically ill patients, whether antipyretics affect mortality.
authors: Intensive Care Research Programme, Medical Research Institute of New Zealand, Wellington, New Zealand. paul.young@ccdhb.org.nz
authors: Paul J
authors: PJ
authors: Young
authors: Manoj K
authors: MK
authors: Saxena
authors: Richard W
authors: RW
authors: Beasley
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects; D058633:Antipyretics / Q000009:adverse effects*; D005334:Fever / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects* / Q000502:physiology; D007239:Infections / Q000276:immunology*
chemical_list: D058633:Antipyretics; D000082:Acetaminophen