title: Dopaminergic drug-induced modulation of the expression of the dopamine transporter in peripheral blood lymphocytes in Parkinson's disease.
abstract: The modulation of expression of the dopamine transporter by dopaminergic drugs was investigated by flow cytometry in peripheral blood lymphocytes from patients suffering Parkinson's disease. An 8-week in vivo exposure to pramipexole (0.7 mg free base, 3 times a day) or ropinirole (12 mg, once daily), but not levodopa/carbidopa (100/25 mg, 3 times a day), significantly reduced the mean fluorescence intensity of the dopamine transporter in peripheral blood lymphocytes. These results demonstrate that levodopa differs from dopamine agonists in its regulation of dopamine transporter expression in peripheral blood lymphocytes.
authors: Movement Disorder Unit, Sant'Andrea Hospital, Department of Neurology and Psychiatry, Sapienza University, Rome, Italy.
authors: Alessandra
authors: A
authors: Fanciulli
authors: Roberta
authors: R
authors: Misasi
authors: Dario
authors: D
authors: Campanelli
authors: Francesca R
authors: FR
authors: Buttarelli
authors: Francesco R
authors: FR
authors: Pontieri
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000494:pharmacology*; D052160:Benzothiazoles / Q000494:pharmacology; D002230:Carbidopa / Q000494:pharmacology; D018491:Dopamine Agonists / Q000494:pharmacology*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D004338:Drug Combinations; D005260:Female; D005434:Flow Cytometry; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000494:pharmacology; D007980:Levodopa / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy*; D000077487:Pramipexole
chemical_list: D000978:Antiparkinson Agents; D052160:Benzothiazoles; D018491:Dopamine Agonists; D050483:Dopamine Plasma Membrane Transport Proteins; D004338:Drug Combinations; D007211:Indoles; C009265:carbidopa, levodopa drug combination; C046649:ropinirole; D007980:Levodopa; D000077487:Pramipexole; D002230:Carbidopa