title: The tubulin colchicine domain: a molecular modeling perspective.
abstract: Computational approaches have been increasingly applied to drug design over the past three decades and have already provided some useful results in the discovery of anticancer drugs. Given the increased availability of crystal structures in recent years, a growing number of molecular modeling studies on tubulin have been reported. Herein we present a brief overview of the role played by computational methods in anti-tubulin research, specifically in the context of colchicine binding agent research. An overview of current structures is reported, along with a brief discussion on the issues associated with the various tubulin isotypes. Finally, a summary of the most recent and relevant results is presented, highlighting the challenges and opportunities faced by researchers in this field.
authors: Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Università degli Studi del Piemonte Orientale A. Avogadro, Novara, Italy. alberto.massarotti@pharm.unipmn.it
authors: Alberto
authors: A
authors: Massarotti
authors: Antonio
authors: A
authors: Coluccia
authors: Romano
authors: R
authors: Silvestri
authors: Giovanni
authors: G
authors: Sorba
authors: Andrea
authors: A
authors: Brancale
mesh_terms: D000818:Animals; D003078:Colchicine / Q000737:chemistry* / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D014404:Tubulin / Q000737:chemistry / Q000378:metabolism*; D050257:Tubulin Modulators / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D014404:Tubulin; D050257:Tubulin Modulators; D003078:Colchicine