title: Dengue--quo tu et quo vadis?
abstract: Dengue viruses (DENV) are by far the most important arboviral pathogens in the tropics around the world, putting at risk of infection nearly a third of the global human population. DENV are members of the genus Flavivirus in the Family Flaviviridae and comprise four antigenically distinct serotypes (DENV-1-4). Although they share almost identical epidemiological features, they are genetically distinct. Phylogenetic analyses have revealed valuable insights into the origins, epidemiology and the forces that shape DENV evolution in nature. In this review, we examine the current status of DENV evolution, including but not limited to rates of evolution, selection pressures, population sizes and evolutionary constraints, and we discuss how these factors influence transmission, pathogenesis and emergence.
authors: Department of Pathology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA. ruchen@utmb.edu
authors: Rubing
authors: R
authors: Chen
authors: Nikos
authors: N
authors: Vasilakis
mesh_terms: D000330:Aedes / Q000821:virology; D000818:Animals; D003715:Dengue / Q000453:epidemiology / Q000635:transmission / Q000821:virology*; D003716:Dengue Virus / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity; D019143:Evolution, Molecular; D014644:Genetic Variation; D006801:Humans; D007303:Insect Vectors / Q000821:virology; D010802:Phylogeny; D012641:Selection, Genetic