title: Regulatory gene network circuits underlying T cell development from multipotent progenitors.
abstract: Regulatory gene circuits enable stem and progenitor cells to detect and process developmental signals and make irreversible fate commitment decisions. To gain insight into the gene circuits underlying T cell fate decision making in progenitor cells, we generated an updated T-lymphocyte developmental gene regulatory network from genes and connections found in the literature. This reconstruction allowed us to identify candidate regulatory gene circuit elements underlying T cell fate decision making. Here, we examine the roles of these circuits in facilitating different aspects of the decision making process, and discuss experiments to further probe their structure and function.
authors: Division of Biology, California Institute of Technology, Pasadena, CA, USA.
authors: Hao Yuan
authors: HY
authors: Kueh
authors: Ellen V
authors: EV
authors: Rothenberg
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D053263:Gene Regulatory Networks; D006801:Humans; D015851:Interleukin-7 / Q000502:physiology; D008213:Lymphocyte Activation / Q000235:genetics / Q000502:physiology*; D051379:Mice; D008954:Models, Biological; D039902:Multipotent Stem Cells / Q000502:physiology*; D051880:Receptors, Notch / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013601:T-Lymphocytes / Q000502:physiology*
chemical_list: D015851:Interleukin-7; D051880:Receptors, Notch