title: Effects of pH on potassium: new explanations for old observations.
abstract: Maintenance of extracellular K(+) concentration within a narrow range is vital for numerous cell functions, particularly electrical excitability of heart and muscle. Potassium homeostasis during intermittent ingestion of K(+) involves rapid redistribution of K(+) into the intracellular space to minimize increases in extracellular K(+) concentration, and ultimate elimination of the K(+) load by renal excretion. Recent years have seen great progress in identifying the transporters and channels involved in renal and extrarenal K(+) homeostasis. Here we apply these advances in molecular physiology to understand how acid-base disturbances affect serum potassium.
authors: Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520-8029, USA. peter.aronson@yale.edu
authors: Peter S
authors: PS
authors: Aronson
authors: Gerhard
authors: G
authors: Giebisch
mesh_terms: D000136:Acid-Base Equilibrium / Q000502:physiology*; D000138:Acidosis / Q000503:physiopathology; D000818:Animals; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006947:Hyperkalemia / Q000503:physiopathology; D007668:Kidney / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology; D011188:Potassium / Q000097:blood / Q000502:physiology* / Q000652:urine; D015221:Potassium Channels / Q000502:physiology*; D017923:Sodium-Hydrogen Exchangers / Q000502:physiology; D000254:Sodium-Potassium-Exchanging ATPase / Q000502:physiology
chemical_list: D015221:Potassium Channels; D017923:Sodium-Hydrogen Exchangers; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium