title: BDNF Val66Met and cognition: all, none, or some? A meta-analysis of the genetic association.
abstract: The Val66Met, G196A (rs6265) polymorphism in the brain-derived neurotrophic factor gene, BDNF, located at 11p13, has been associated with a wide range of cognitive functions. Yet, the pattern of results is complex and conflicting. In this study, we conducted a meta-analysis that included 23 publications containing 31 independent samples comprised of 7095 individuals. The phenotypes that were examined in this analysis covered a wide variety of cognitive functions and included indicators of general cognitive ability, memory, executive function, visual processing skills and cognitive fluency. The meta-analysis did not establish significant genetic associations between the Val66Met polymorphism and any of the phenotypes that were included.
authors: Human Development, Teachers College, Columbia University, New York, NY, USA.
authors: S D
authors: SD
authors: Mandelman
authors: E L
authors: EL
authors: Grigorenko
mesh_terms: D000483:Alleles; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D003071:Cognition / Q000502:physiology*; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D009483:Neuropsychological Tests; D020641:Polymorphism, Single Nucleotide
chemical_list: D019208:Brain-Derived Neurotrophic Factor