title: Bioresponsive mesoporous silica nanoparticles for triggered drug release.
abstract: Mesoporous silica nanoparticles (MSNPs) have garnered a great deal of attention as potential carriers for therapeutic payloads. However, achieving triggered drug release from MSNPs in vivo has been challenging. Here, we describe the synthesis of stimulus-responsive polymer-coated MSNPs and the loading of therapeutics into both the core and shell domains. We characterize MSNP drug-eluting properties in vitro and demonstrate that the polymer-coated MSNPs release doxorubicin in response to proteases present at a tumor site in vivo, resulting in cellular apoptosis. These results demonstrate the utility of polymer-coated nanoparticles in specifically delivering an antitumor payload.
authors: Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute Technology, Cambridge, Massachusetts 02139, USA.
authors: Neetu
authors: N
authors: Singh
authors: Amrita
authors: A
authors: Karambelkar
authors: Luo
authors: L
authors: Gu
authors: Kevin
authors: K
authors: Lin
authors: Jordan S
authors: JS
authors: Miller
authors: Christopher S
authors: CS
authors: Chen
authors: Michael J
authors: MJ
authors: Sailor
authors: Sangeeta N
authors: SN
authors: Bhatia
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000378:metabolism; D004317:Doxorubicin / Q000008:administration & dosage* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000188:drug therapy; D010447:Peptide Hydrolases / Q000378:metabolism; D011108:Polymers / Q000737:chemistry / Q000378:metabolism; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000903:Antibiotics, Antineoplastic; D003692:Delayed-Action Preparations; D011108:Polymers; D012822:Silicon Dioxide; D004317:Doxorubicin; D010447:Peptide Hydrolases