title: Saurian papulosis: a new clinicopathological entity.
abstract: BACKGROUND
  Epidermal keratinization disorders comprise a heterogeneous group of skin diseases that share the common feature of abnormal epidermal maturation, often leading to a disturbed stratum corneum.
  
  
  OBJECTIVE
  To describe two cases of an unusual disorder of epidermal keratinization.
  
  
  METHODS
  The clinical features of two unrelated patients with a long-standing widespread cutaneous eruption are described. Histopathologic examination and immunohistochemical studies were performed on skin biopsy specimens.
  
  
  RESULTS
  The eruption was characterized by symmetric erythematous, flat, discrete papules with a polygonal shape and fine scaling. The papules covered most of the skin surface and, in some areas of the trunk, they were arranged along the lines of cleavage, parallel to the ribs. There was no facial, mucosal, nail, or palmoplantar involvement; the teeth and hair were normal. The first patient had a sister with an identical eruption, and a brother of the second patient was said to have similar skin lesions. Histopathology revealed well-demarcated areas of compact eosinophilic orthokeratotic hyperkeratosis overlying a slightly acanthotic epidermis. Lesional skin showed weaker immunoexpression for connexin 43 compared with normal skin.
  
  
  CONCLUSIONS
  Only two patients and one sibling were investigated.
  
  
  CONCLUSIONS
  We propose the name "saurian papulosis" to describe this newly described clinicopathologic entity.
authors: Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
authors: Ana María
authors: AM
authors: Molina-Ruiz
authors: María
authors: M
authors: del Carmen Fariña
authors: Loreto
authors: L
authors: Carrasco
authors: Carlos
authors: C
authors: Santonja
authors: José Luis
authors: JL
authors: Rodríguez-Peralto
authors: Antonio
authors: A
authors: Torrelo
authors: Heinz
authors: H
authors: Kutzner
authors: Luis
authors: L
authors: Requena
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000235:genetics; D007642:Keratosis / Q000175:diagnosis / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D008297:Male; D012867:Skin / Q000473:pathology*
chemical_list: D007633:Keratins