title: Fasting and post-glucose load measures of insulin resistance and risk of ischemic stroke in older adults.
abstract: OBJECTIVE
  Few studies have assessed post-glucose load measures of insulin resistance and ischemic stroke risk, and data are sparse for older adults. We investigated whether fasting and post-glucose load measures of insulin resistance were related to incident ischemic stroke in nondiabetic, older adults.
  
  
  METHODS
  Participants were men and women in the Cardiovascular Health Study, age 65+ years and without prevalent diabetes or stroke at baseline, followed for 17 years for incident ischemic stroke. The Gutt insulin sensitivity index was calculated from baseline body weight and from fasting and 2-hour postload insulin and glucose; a lower Gutt index indicates higher insulin resistance.
  
  
  RESULTS
  Analyses included 3442 participants (42% men) with a mean age of 73 years. Incidence of ischemic stroke was 9.8 strokes per 1000 person-years. The relative risk (RR) for lowest quartile versus highest quartile of Gutt index was 1.64 (95% CI, 1.24-2.16), adjusted for demographics and prevalent cardiovascular and kidney disease. Similarly, the adjusted RR for highest quartile versus lowest quartile of 2-hour glucose was 1.84 (95% CI, 1.39-2.42). In contrast, the adjusted RR for highest quartile versus lowest quartile of fasting insulin was 1.10 (95% CI, 0.84-1.46).
  
  
  CONCLUSIONS
  In nondiabetic, older adults, insulin resistance measured by Gutt index or 2-hour glucose, but not by fasting insulin, was associated with risk of incident ischemic stroke.
authors: Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, SM, 1730 Minor Avenue, Ste 1360, Seattle, WA 98101, USA. ethacker@uw.edu
authors: Evan L
authors: EL
authors: Thacker
authors: Bruce M
authors: BM
authors: Psaty
authors: Barbara
authors: B
authors: McKnight
authors: Susan R
authors: SR
authors: Heckbert
authors: W T
authors: WT
authors: Longstreth
authors: Kenneth J
authors: KJ
authors: Mukamal
authors: James B
authors: JB
authors: Meigs
authors: Ian H
authors: IH
authors: de Boer
authors: Edward J
authors: EJ
authors: Boyko
authors: Mercedes R
authors: MR
authors: Carnethon
authors: Jorge R
authors: JR
authors: Kizer
authors: Russell P
authors: RP
authors: Tracy
authors: Nicholas L
authors: NL
authors: Smith
authors: David S
authors: DS
authors: Siscovick
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose; D015992:Body Mass Index; D002545:Brain Ischemia / Q000453:epidemiology* / Q000378:metabolism; D005215:Fasting / Q000378:metabolism*; D005260:Female; D006801:Humans; D015994:Incidence; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D012306:Risk; D020521:Stroke / Q000453:epidemiology* / Q000378:metabolism
chemical_list: D001786:Blood Glucose