title: Evaluation of cytotoxic and radical-scavenging activities of root extracts of Schleichera oleosa (Lour.) Oken.
abstract: In the present study root extracts of Schleichera oleosa were prepared and analysed for hydroxyl radical scavenging potential in different in vitro models, such as deoxyribose degradation (site-specific and non-site specific) and plasmid nicking assays. The extracts were found to have profound effects in both assays by scavenging of hydroxyl radicals. The extracts were also assessed for in vitro cytotoxicity in a sulphorhodamine B dye assay against a panel of cell lines representing different types of human cancers and tissues, wherein the methanol, ethyl acetate and water extracts were found to effectively inhibit the growth of selective cell lines. The results of the present study suggests the presence of antioxidant constituents in the methanol and ethyl acetate extracts of the roots of S. oleosa, results which are in concurrence with preliminary ¹H NMR and IR studies that suggest the presence of polyphenolic compounds.
authors: Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar-143005, Punjab, India.
authors: Tarunpreet Singh
authors: TS
authors: Thind
authors: Geetanjali
authors: G
authors: Rampal
authors: Satyam Kumar
authors: SK
authors: Agrawal
authors: A K
authors: AK
authors: Saxena
authors: Saroj
authors: S
authors: Arora
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D029631:Sapindaceae / Q000737:chemistry*
chemical_list: D016166:Free Radical Scavengers; D010936:Plant Extracts