title: Colorectal cancer presenting with dysarthria and ataxia: a case of isolated leptomeningeal metastasis.
abstract: We report the case of a 72-year-old man who presented with weight loss, anorexia and a change in bowel habit. Computed tomography (CT) of the chest, abdomen and pelvis demonstrated widespread thoracic and abdominal lymphadenopathy and a lesion within the splenic flexure. This was confirmed  as an adenocarcinoma after a colonoscopic biopsy. A CT guided biopsy of the abdominal lymph node confirmed the adenocarcinoma. Within three days of admission, the patient developed worsening, progressive cerebellar symptoms that left the patient aphasic and bed bound. CT of the head was reported  as normal. Magnetic resonance imaging of the head demonstrated widespread leptomeningeal metastases. We describe a case of isolated leptomeningeal metastasis from a colorectal primary tumour.
authors: Department of General Surgery, Norfolk and Norwich University Hospital, Norwich, UK. rajlahiri@doctors.org.uk
authors: R P
authors: RP
authors: Lahiri
authors: K M
authors: KM
authors: Burnand
authors: A
authors: A
authors: Bandi
authors: N
authors: N
authors: Farooq
authors: T
authors: T
authors: Sathesh-Kumar
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary*; D000368:Aged; D002524:Cerebellar Ataxia / Q000000981:diagnostic imaging / Q000209:etiology*; D015179:Colorectal Neoplasms / Q000150:complications*; D004401:Dysarthria / Q000209:etiology*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D055756:Meningeal Carcinomatosis / Q000000981:diagnostic imaging / Q000556:secondary*; D014057:Tomography, X-Ray Computed