title: The acceptance of in silico models for REACH: Requirements, barriers, and perspectives.
abstract: In silico models have prompted considerable interest and debate because of their potential value in predicting the properties of chemical substances for regulatory purposes. The European REACH legislation promotes innovation and encourages the use of alternative methods, but in practice the use of in silico models is still very limited. There are many stakeholders influencing the regulatory trajectory of quantitative structure-activity relationships (QSAR) models, including regulators, industry, model developers and consultants. Here we outline some of the issues and challenges involved in the acceptance of these methods for regulatory purposes.
authors: Istituto di Ricerche Farmacologiche "Mario Negri", Via La Masa 19, 20156, Milano, Italy. emilio.benfenati@marionegri.it.
authors: Emilio
authors: E
authors: Benfenati
authors: Rodolfo Gonella
authors: RG
authors: Diaza
authors: Antonio
authors: A
authors: Cassano
authors: Simon
authors: S
authors: Pardoe
authors: Giuseppina
authors: G
authors: Gini
authors: Claire
authors: C
authors: Mays
authors: Ralf
authors: R
authors: Knauf
authors: Ludger
authors: L
authors: Benighaus