title: Detection of adeno-associated virus viremia in hematopoietic cell transplant recipients.
abstract: Adeno-associated virus (AAV) is widely considered to be nonpathogenic, but the clinical epidemiology of this virus is limited. By use of polymerase chain reaction assays, we investigated the incidence and clinical significance of AAV viremia in a population of consecutive recipients of a hematopoietic cell transplant (HCT). Four (2.8%) of 145 patients developed AAV viremia after HCT. Viremia was low level and transient in all patients. Two patients were admitted to the hospital and died in proximity to AAV viremia (<7 weeks between diagnosis and death); however, AAV was not detected in tissue specimens obtained at autopsy. Thus, AAV does not appear to play a pathogenic role in organ-specific illness, even in a highly immunocompromised population.
authors: Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
authors: Judson
authors: J
authors: Heugel
authors: Michael
authors: M
authors: Boeckh
authors: Meei-Li
authors: ML
authors: Huang
authors: Becky
authors: B
authors: Dierks
authors: Robert
authors: R
authors: Hackman
authors: David
authors: D
authors: Fredricks
authors: Jane
authors: J
authors: Kuypers
authors: Lawrence
authors: L
authors: Corey
mesh_terms: D000293:Adolescent; D000328:Adult; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology / Q000821:virology*; D000229:Dependovirus / Q000302:isolation & purification*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged; D010322:Parvoviridae Infections / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D060888:Real-Time Polymerase Chain Reaction; D019562:Viral Load; D014766:Viremia / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D055815:Young Adult