title: Construction of a tunable metallohydrolase center on an invertible molecular pocket.
abstract: A trimer of cholic acid made by linking three cholic acid molecules with pentaerythritol via click chemistry serves as the center of an artificial metallohydrolase after the complexation of the triazole groups with a Zn(2+) ion. The invertible amphiphilic cavity can respond to the change in polarity of the solvent media and efficiently modulate the catalytic activity of the artificial enzyme.
authors: State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, 130012, China.
authors: Zhiming
authors: Z
authors: Zhang
authors: Junqiu
authors: J
authors: Liu
authors: Quan
authors: Q
authors: Luo
authors: Jiawei
authors: J
authors: Zhang
authors: Jiayun
authors: J
authors: Xu
authors: X X
authors: XX
authors: Zhu
mesh_terms: D019826:Cholic Acid / Q000737:chemistry; D057930:Click Chemistry; D006867:Hydrolases / Q000737:chemistry* / Q000378:metabolism*; D008666:Metalloendopeptidases / Q000737:chemistry* / Q000378:metabolism*; D008958:Models, Molecular; D015394:Molecular Structure; D011409:Propylene Glycols / Q000737:chemistry; D013237:Stereoisomerism; D014230:Triazoles / Q000737:chemistry
chemical_list: D011409:Propylene Glycols; D014230:Triazoles; D006867:Hydrolases; D008666:Metalloendopeptidases; D019826:Cholic Acid; C008783:pentaerythritol