title: Mouse atlas registration with non-tomographic imaging modalities-a pilot study based on simulation.
abstract: OBJECTIVE
  This study investigates methodologies for the estimation of small animal anatomy from non-tomographic modalities, such as planar X-ray projections, optical cameras, and surface scanners. The key goal is to register a digital mouse atlas to a combination of non-tomographic modalities, in order to provide organ-level anatomical references of small animals in 3D.
  
  
  METHODS
  A 2D/3D registration method was developed to register the 3D atlas to the combination of non-tomographic imaging modalities. Eleven combinations of three non-tomographic imaging modalities were simulated, and the registration accuracy of each combination was evaluated.
  
  
  RESULTS
  Comparing the 11 combinations, the top-view X-ray projection combined with the side-view optical camera yielded the best overall registration accuracy of all organs. The use of a surface scanner improved the registration accuracy of skin, spleen, and kidneys.
  
  
  CONCLUSIONS
  The methodologies and evaluation presented in this study should provide helpful information for designing preclinical atlas-based anatomical data acquisition systems.
authors: Crump Institute of Molecular Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA. wang.hongkai@gmail.com
authors: Hongkai
authors: H
authors: Wang
authors: David B
authors: DB
authors: Stout
authors: Arion F
authors: AF
authors: Chatziioannou
mesh_terms: D000716:Anatomy, Artistic; D000818:Animals; D001271:Atlases as Topic; D003198:Computer Simulation; D021621:Imaging, Three-Dimensional / Q000379:methods*; D051379:Mice; D019047:Phantoms, Imaging; D010865:Pilot Projects; D014054:Tomography / Q000379:methods*