title: Analgesic and anti-inflammatory activities of the sesquiterpene fraction from Annona reticulata L. bark.
abstract: The sesquiterpene fraction of Annona reticulata bark was studied by GC/MS. Three major components were identified: copaene (35.40%), patchoulane (13.49%) and 1H-cycloprop(e)azulene (22.77%). The fraction was also screened for its analgesic and anti-inflammatory activities. The sesquiterpene fraction at doses 12.5 and 25 mg kg⁻¹ and the unsaponified petroleum ether extract at a dose of 50 mg kg⁻¹ exhibited significant central as well as peripheral analgesic and anti-inflammatory activities. These activities were comparable with the standard drugs used in the respective experiments.
authors: Department of Pharmacognosy, Amrutvahini College of Pharmacy, Sangamner District, Ahmednagar 422605, Maharashtra, India.
authors: Machindra J
authors: MJ
authors: Chavan
authors: Pravin S
authors: PS
authors: Wakte
authors: Devanand B
authors: DB
authors: Shinde
mesh_terms: D000700:Analgesics / Q000737:chemistry* / Q000627:therapeutic use*; D000818:Animals; D031041:Annona / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000627:therapeutic use*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D008401:Gas Chromatography-Mass Spectrometry; D008297:Male; D051379:Mice; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012717:Sesquiterpenes / Q000737:chemistry* / Q000627:therapeutic use*
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D012717:Sesquiterpenes