title: Synthesis and antimicrobial activity of brominated resorcinol dimers.
abstract: Dibrominated resorcinol dimers were synthesized by reaction of 4-bromoresorcinol with aldehydes under reflux in ethanol in the presence of HCl. Subsequent dehalogenation yielded the corresponding monobrominated compounds and a fully dehalogenated dimer. Of the dimers, 6,6'-((4-hydroxyphenyl)methylene)bis(4-bromobenzene-1,3-diol) (4) displayed potent antibacterial activity and inhibitory activity against isocitrate lyase Candida albicans.
authors: School of Pharmacy, University of East Anglia, Norwich, United Kingdom.
authors: Elise
authors: E
authors: Bouthenet
authors: Ki-Bong
authors: KB
authors: Oh
authors: Seungil
authors: S
authors: Park
authors: Navjeet K
authors: NK
authors: Nagi
authors: Hyi-Seung
authors: HS
authors: Lee
authors: Susan E
authors: SE
authors: Matthews
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000201:enzymology; D019281:Dimerization; D054879:Halogenation; D020128:Inhibitory Concentration 50; D007522:Isocitrate Lyase / Q000037:antagonists & inhibitors; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012118:Resorcinols / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: C571323:6,6'-((4-hydroxyphenyl)methylene)bis(4-bromobenzene-1,3-diol); D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D012118:Resorcinols; D007522:Isocitrate Lyase; C031389:resorcinol