title: Paradoxical interplay of viral and cellular functions.
abstract: Some cellular editing functions can restrict the replication of some viruses but contribute to completion of the life cycle of others. A recent study has identified an isoform of the adenosine deaminase acting on RNA type 1 (ADAR 1) as required for embryogenesis, and as a restriction factor for a number of important RNA virus pathogens. The dual implication of key cellular functions in the innate immunity against viruses, or, paradoxically, as mediators of virus replication is interpreted in the light of the concept of virus-host coevolution and tinkering proposed for general evolution by François Jacob decades ago.
authors: Centro de Biología Molecular Severo Ochoa (CSIC-UAM), C/ Nicolás Cabrera, 1, Cantoblanco, Madrid 28049, Spain.|Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona 08036, Spain.
authors: Esteban
authors: E
authors: Domingo
mesh_terms: D000243:Adenosine Deaminase / Q000378:metabolism*; D006801:Humans; D017393:RNA Editing; D012327:RNA Virus Infections / Q000201:enzymology* / Q000821:virology; D012328:RNA Viruses / Q000235:genetics* / Q000502:physiology; D014779:Virus Replication; D014780:Viruses / Q000235:genetics
chemical_list: D000243:Adenosine Deaminase