title: Anti-inflammatory activity of Gentiana striata Maxim.
abstract: The anti-inflammatory activity and the mechanism of action of Gentiana striata Maxim. has been investigated. The most active phase, the ethyl acetate extract of Gentiana striata Maxim. (EGS), displayed potent inhibitory activity on feet oedema of rheumatoid arthritis (RA) inflicted rats. This anti-inflammatory activity might be partly based on the notable reduction of prostaglandin E2 (PGE₂) and nitric oxide (NO) levels. Six further compounds isolated from EGS have previously been reported as having anti-inflammatory activity.
authors: School of Pharmacy, Lanzhou University, Lanzhou, Gansu Province 730000, China.
authors: Feihua
authors: F
authors: Cao
authors: Hao
authors: H
authors: Shao
authors: Qiang
authors: Q
authors: Li
authors: Jinrong
authors: J
authors: Li
authors: Wenqun
authors: W
authors: Li
authors: Chong
authors: C
authors: Li
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D015232:Dinoprostone / Q000378:metabolism; D030012:Gentiana / Q000737:chemistry*; D009569:Nitric Oxide / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D009569:Nitric Oxide; D015232:Dinoprostone