title: Fast Dixon whole-body MRI for detecting distant cancer metastasis: a preliminary clinical study.
abstract: OBJECTIVE
  To evaluate the feasibility of fast Dixon whole-body (WB) magnetic resonance imaging (MRI) for detecting bone and liver metastasis in clinical patients and to compare its performance with skeletal scintigraphy (SS) for detecting bone metastases using reference imaging with >1 year follow-up as the gold standard.
  
  
  METHODS
  Twenty-nine patients with bone metastases prospectively underwent WB MRI and SS. WB MRI included coronal T2, axial T1 with and without intravenous gadolinium (including triphasic liver sequences), and axial diffusion-weighted imaging, plus spinal sagittal postcontrast T1-weighted images. The skeleton was divided into 16 segments. Reviewers blinded to other images identified up to five lesions per segment and rated them using a five-point confidence scale for metastatic disease. Sensitivities and specificities were compared using the McNemar test.
  
  
  RESULTS
  The sensitivity of WB MRI and SS in detecting bone metastases was 70.8% and 59.6% (P = 0.003), respectively; specificity was 89.1% and 98.7% (P < 0.0001). WB MRI detected all livers with metastases (n = 8). One focal nodular hyperplasia was classified as a metastasis on WB MRI.
  
  
  CONCLUSIONS
  Fast Dixon WB MRI is feasible in clinical patients, highly specific, and more sensitive than SS in detecting bone metastases, and can detect metastases of the liver.
authors: Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. ccostelloe@di.mdacc.tmc.edu
authors: Colleen M
authors: CM
authors: Costelloe
authors: Vikas
authors: V
authors: Kundra
authors: Jingfei
authors: J
authors: Ma
authors: Beth A
authors: BA
authors: Chasen
authors: Eric M
authors: EM
authors: Rohren
authors: Roland L
authors: RL
authors: Bassett
authors: John E
authors: JE
authors: Madewell
mesh_terms: D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000556:secondary*; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000175:diagnosis* / Q000000981:diagnostic imaging; D011446:Prospective Studies; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed; D051598:Whole Body Imaging
chemical_list: D003287:Contrast Media