title: [Association of the IL-6 gene 634C/G polymorphism with susceptibility to endometriosis].
abstract: OBJECTIVE
  To investigate the association of interleukin 6 gene (IL-6) promoter region 634C/G (rs1800796) single nucleotide polymorphism (SNP) with the genetic susceptibility to endometriosis (Ems) in south Han Chinese women.
  
  
  METHODS
  A case-control study was performed in 432 Ems patients and 499 control women to evaluate the SNP of IL-6 634C/G by using a fluorescent quantitative PCR-based high resolution melting (HRM) method.
  
  
  RESULTS
  There were statistical significances in the IL-6 634C/G alleles, whether or not to carry allele G and genotype distributions between Ems patients and control women (P=0.032, 0.014 and 0.045, respectively). Allele C enhanced the risk of Ems 1.057 times while allele G reduced the risk of Ems 0.835 time. Carrying allele G reduced the risk of Ems 0.822 time, whereas not carrying allele G enhanced the risk of Ems 1.143 times. Compared with genotype CC, the risk of Ems with genotype CG reduced 0.704 time (95% CI: 0.533-0.931). There was no significant difference in whether or not carrying allele G distribution between Ems patients and control women (P=0.729).
  
  
  CONCLUSIONS
  The present study demonstrated significant association between the SNP of IL-6 634C/G and genetic susceptibility to Ems in south Han Chinese women.
authors: Department of Gynecology and Obstetrics, Southern Medical University, Guangdong, People's Republic of China.
authors: Ting
authors: T
authors: Mao
authors: Li-li
authors: LL
authors: Zong
authors: Yu-feng
authors: YF
authors: Wang
authors: Xin
authors: X
authors: Zhao
authors: Yong-gui
authors: YG
authors: Fu
authors: Jun
authors: J
authors: Zeng
authors: Xing-qiang
authors: XQ
authors: Rao
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D015850:Interleukin-6