title: Synovial sarcoma of the tongue confirmed by molecular detection of the SYT-SSX2 fusion gene transcript.
abstract: Involvement of the tongue by a synovial sarcoma (SS) is an extremely rare event; there have only been 13 cases previously reported. The authors present herein a case of monophasic SS arising in the tongue in a 32-year-old woman. The neoplasm expressed cytokeratins AE1-3, OSCAR, and EMA as well as Bcl-2 and TLE1. Molecular analysis indicated that the patient tested positive for the SYT/SS2 fusion transcript.
authors: The American British Cowdray Medical Centre, Mexico City, Mexico.
authors: Jaime
authors: J
authors: Villaroel-Salinas
authors: Jesús
authors: J
authors: Campos-Martinez
authors: Carlos
authors: C
authors: Ortiz-Hidalgo
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D049109:Cell Proliferation; D056970:Co-Repressor Proteins; D005260:Female; D006801:Humans; D053558:Keratin-3 / Q000378:metabolism; D018396:Mucin-1 / Q000378:metabolism; D015514:Oncogene Proteins, Fusion / Q000235:genetics* / Q000378:metabolism; D057089:Pathology, Molecular / Q000379:methods*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D013584:Sarcoma, Synovial / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D014059:Tongue / Q000473:pathology / Q000601:surgery; D014062:Tongue Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D056970:Co-Repressor Proteins; D053558:Keratin-3; D018396:Mucin-1; C512828:OSCAR protein, human; D015514:Oncogene Proteins, Fusion; D019253:Proto-Oncogene Proteins c-bcl-2; D011956:Receptors, Cell Surface; D012097:Repressor Proteins; C116512:SYT-SSX fusion protein; C499043:TLE1 protein, human