title: Antiarthritic activity of various extracts of Mesua ferrea Linn. seed.
abstract: BACKGROUND
  Mesua ferrea Linn. (Cluciaseae), Cobra's saffron, is named after the heaviness of its timber and is cultivated in tropical climates for its form, foliage, and fragrant flowers. It is prescribed in the Ayurvedic literature for the treatment of pain, inflammation, and rheumatic conditions.
  
  
  OBJECTIVE
  In present investigation, activity of Mesua ferrea and its evaluation in the formaldehyde and Complete Freund's Adjuvant (CFA)-induced arthritis in rats is reported.
  
  
  METHODS
  The extracts obtained from successive extraction were subjected to preliminary phytochemical investigation and antiarthritic activity was evaluated by inducing formaldehyde and CFA. Body weight changes and haematological parameters were measured.
  
  
  RESULTS
  The results indicate that Mesua ferrea protects rats against formaldehyde and CFA induced arthritis. The body weight changes and haematological perturbations induced by CFA were maintained. The overall results indicated that Mesua ferrea exerts a potent protective effect against formaldehyde and adjuvant-induced arthritis in rats.
  
  
  CONCLUSIONS
  These findings demonstrate that the present study validates the ethnomedicinal use of seeds of Mesua ferrea in the treatment of arthritis conditions.
authors: Department of Pharmacognosy, KLEUs' College of Pharmacy, Belgaum, Karnataka, India. jalalpuresunil@rediffmail.com
authors: Sunil S
authors: SS
authors: Jalalpure
authors: Yuvaraj D
authors: YD
authors: Mandavkar
authors: Pallavi R
authors: PR
authors: Khalure
authors: Gulab S
authors: GS
authors: Shinde
authors: Pournima A
authors: PA
authors: Shelar
authors: Amol S
authors: AS
authors: Shah
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use* / Q000633:toxicity; D001169:Arthritis, Experimental / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D004487:Edema / Q000097:blood / Q000188:drug therapy*; D004906:Erythrocyte Count; D005260:Female; D005557:Formaldehyde; D005620:Freund's Adjuvant; D006454:Hemoglobins / Q000378:metabolism; D007194:India; D007958:Leukocyte Count; D019684:Magnoliopsida; D008297:Male; D008515:Medicine, Ayurvedic; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use* / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D023382:Toxicity Tests, Acute
chemical_list: D000893:Anti-Inflammatory Agents; D006454:Hemoglobins; D010936:Plant Extracts; D012997:Solvents; D005557:Formaldehyde; D005620:Freund's Adjuvant