title: An expert consortium review of the EC-commissioned report "alternative (Non-Animal) methods for cosmetics testing: current status and future prospects - 2010".
abstract: The European cosmetics legislation foresees a review in 2011 and possible postponement of the 2013 marketing ban to enforce the testing ban for systemic and repeated-dose animal tests. For this purpose, a 119-page report commissioned by the European Commission was published recently. Here, a group of 17 independent experts from the US, Europe, and Japan was brought together to evaluate the report. The expert panel strongly endorsed the report and its conclusions. A number of important options not considered were identified; these do not, however, affect the overall conclusions regarding the current lack of availability of a full replacement, especially for the areas of repeated dose toxicity, carcinogenicity testing, and reproductive toxicity, though a roadmap for change is emerging. However, some of these options may provide adequate data for replacement of some animal studies in the near future pending validation. Various recommendations expand the original report. The reviewers agree with the report that there is greater promise in the short term for the areas of sensitization and toxicokinetics. Additional opportunities lie in more global collaborations and the inclusion of other industry sectors.
authors: Johns Hopkins University, Bloomberg School of Public Health, Center for Alternatives to Animal Testing, Baltimore, MD 21205, USA. THartung@jhsph.edu
authors: Thomas
authors: T
authors: Hartung
authors: Bas J
authors: BJ
authors: Blaauboer
authors: Sieto
authors: S
authors: Bosgra
authors: Edward
authors: E
authors: Carney
authors: Joachim
authors: J
authors: Coenen
authors: Rory B
authors: RB
authors: Conolly
authors: Emanuela
authors: E
authors: Corsini
authors: Sidney
authors: S
authors: Green
authors: Elaine M
authors: EM
authors: Faustman
authors: Anthony
authors: A
authors: Gaspari
authors: Makoto
authors: M
authors: Hayashi
authors: A
authors: A
authors: Wallace Hayes
authors: Jan G
authors: JG
authors: Hengstler
authors: Lisbeth E
authors: LE
authors: Knudsen
authors: Thomas B
authors: TB
authors: Knudsen
authors: James M
authors: JM
authors: McKim
authors: Walter
authors: W
authors: Pfaller
authors: Erwin L
authors: EL
authors: Roggen
mesh_terms: D000826:Animal Testing Alternatives / Q000379:methods* / Q000592:standards*; D000818:Animals; D003358:Cosmetics / Q000592:standards* / Q000633:toxicity*; D005062:European Union; D005104:Expert Testimony; D018675:Toxicity Tests / Q000379:methods* / Q000592:standards*
chemical_list: D003358:Cosmetics