title: Amyloid-β associated volume loss occurs only in the presence of phospho-tau.
abstract: The relationship between neurodegeneration and the 2 hallmark proteins of Alzheimer's disease, amyloid-β (Aβ) and tau, is still unclear. Here, we examined 286 nondemented participants (107 cognitively normal older adults and 179 memory impaired individuals) who underwent longitudinal magnetic resonance (MR) imaging and lumbar puncture. Using mixed effects models, we investigated the relationship between longitudinal entorhinal cortex atrophy rate, cerebrospinal fluid (CSF) p-tau(181p) and CSF Aβ(1-42) . We found a significant relationship between elevated entorhinal cortex atrophy rate and decreased CSF Aβ(1-42) only with elevated CSF p-tau(181p) . Our findings indicate that Aβ-associated volume loss occurs only in the presence of phospho-tau in humans at risk for dementia.
authors: Department of Radiology, University of California-San Diego, La Jolla 92037, CA.
authors: Rahul S
authors: RS
authors: Desikan
authors: Linda K
authors: LK
authors: McEvoy
authors: Wesley K
authors: WK
authors: Thompson
authors: Dominic
authors: D
authors: Holland
authors: J Cooper
authors: JC
authors: Roddey
authors: Kaj
authors: K
authors: Blennow
authors: Paul S
authors: PS
authors: Aisen
authors: James B
authors: JB
authors: Brewer
authors: Bradley T
authors: BT
authors: Hyman
authors: Anders M
authors: AM
authors: Dale
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000647:Amnesia / Q000134:cerebrospinal fluid* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D001284:Atrophy; D002540:Cerebral Cortex / Q000473:pathology*; D060825:Cognitive Dysfunction / Q000134:cerebrospinal fluid* / Q000473:pathology; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D010446:Peptide Fragments / Q000134:cerebrospinal fluid*; D016875:tau Proteins / Q000134:cerebrospinal fluid*
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D016875:tau Proteins