title: TP53 mutations in canine brain tumors.
abstract: The p53 tumor suppressor gene (TP53) is the most frequently altered gene in human cancer. Mutation of the gene has been shown to be an important mechanism of p53 pathway inactivation in a variety of human brain tumors, particularly those of astrocytic origin. Genomic DNA from a series of 37 glial and 51 nonglial canine brain tumors was sequenced to determine the frequency of TP53 gene mutations involving exons 3-9. Exonic mutations were found in 3 of 88 tumors (3.4%) and specifically in 1 of 18 astrocytic tumors (5.5%). This is markedly lower than that reported in comparable human tumors, suggesting that alternative mechanisms of p53 inactivation are likely to be present if p53 function contributes significantly to oncogenesis in canine brain tumors.
authors: Department of Surgical and Radiological Sciences, Tupper Hall, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
authors: D
authors: D
authors: York
authors: R J
authors: RJ
authors: Higgins
authors: R A
authors: RA
authors: LeCouteur
authors: A N
authors: AN
authors: Wolfe
authors: R
authors: R
authors: Grahn
authors: N
authors: N
authors: Olby
authors: M
authors: M
authors: Campbell
authors: P J
authors: PJ
authors: Dickinson
mesh_terms: D000818:Animals; D001254:Astrocytoma / Q000235:genetics / Q000662:veterinary*; D001932:Brain Neoplasms / Q000235:genetics / Q000662:veterinary*; D018076:DNA, Complementary / Q000235:genetics; D004273:DNA, Neoplasm / Q000737:chemistry / Q000235:genetics; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D005091:Exons / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D016158:Genes, p53 / Q000235:genetics*; D008297:Male; D009154:Mutation; D012334:RNA, Neoplasm / Q000235:genetics; D017422:Sequence Analysis, DNA
chemical_list: D018076:DNA, Complementary; D004273:DNA, Neoplasm; D012334:RNA, Neoplasm