title: Protein-resistant and fibrinolytic polyurethane surfaces.
abstract: Surfaces with resistance to non-specific protein adsorption and a high capacity to bind plasminogen from plasma are developed for application as fibrinolytic surfaces in blood contact. A new method is reported for grafting poly(OEGMA-co-HEMA) copolymers on polyurethane surfaces. The OEGMA provides effective protein resistance due to the PEG side chains and the HEMA provides a high density of OH groups for attachment of lysine. Adsorption of fibrinogen from buffer and plasma to these surfaces is low, indicating significant protein resistance. Plasminogen binding from plasma is high, and clot dissolution on surfaces where plasminogen adsorbed from plasma is converted to plasmin is rapid.
authors: Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, Department of Polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Soochow, China.
authors: Zhaoqiang
authors: Z
authors: Wu
authors: Hong
authors: H
authors: Chen
authors: Xiaoli
authors: X
authors: Liu
authors: John L
authors: JL
authors: Brash
mesh_terms: D000327:Adsorption; D005340:Fibrinogen / Q000378:metabolism*; D005341:Fibrinolysin / Q000378:metabolism; D005342:Fibrinolysis; D005343:Fibrinolytic Agents / Q000378:metabolism*; D008239:Lysine / Q000378:metabolism; D008689:Methacrylates / Q000737:chemistry / Q000378:metabolism*; D010949:Plasma / Q000378:metabolism*; D010958:Plasminogen / Q000378:metabolism*; D011092:Polyethylene Glycols / Q000737:chemistry / Q000378:metabolism*; D011140:Polyurethanes / Q000737:chemistry / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D013499:Surface Properties
chemical_list: D005343:Fibrinolytic Agents; D008689:Methacrylates; D011140:Polyurethanes; D011506:Proteins; C524499:polyethylene glycol methacrylate; D011092:Polyethylene Glycols; C005044:hydroxyethyl methacrylate; D005340:Fibrinogen; D010958:Plasminogen; D005341:Fibrinolysin; D008239:Lysine