title: Molecular design, synthesis and bioactivity of glycosyl hydrazine and hydrazone derivatives: notable effects of the sugar moiety.
abstract: Assuming that the water solubility of our previous hydrazone derivatives would improve after modification with sugars while keeping or modulating their notable biological activities, we designed and synthesized some glycosyl hydrazine and hydrazone derivatives. Bioassay results indicated that the antitumor activity of our previously prepared hydrazones reduced or disappeared after modification with sugars. On the contrary, some glycosyl derivatives displayed much better antifungal activity against selected fungi. Obviously, a small sugar can change the biological activity of hydrazones significantly.
authors: Department of Applied Chemistry, College of Science, China Agricultural University, Beijing, People's Republic of China.
authors: Zining
authors: Z
authors: Cui
authors: Xinling
authors: X
authors: Yang
authors: Yanxia
authors: Y
authors: Shi
authors: Hirotaka
authors: H
authors: Uzawa
authors: Jingrong
authors: J
authors: Cui
authors: Hirofumi
authors: H
authors: Dohi
authors: Yoshihiro
authors: Y
authors: Nishida
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002241:Carbohydrates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D005658:Fungi / Q000187:drug effects*; D006031:Glycosylation; D006834:Hydrazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006835:Hydrazones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D012995:Solubility; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents; D002241:Carbohydrates; D006834:Hydrazines; D006835:Hydrazones