title: Synthesis of analogues of ochratoxin A.
abstract: Four analogues of ochratoxin A (OTA) differing for the aminoacidic moiety were synthesised using ochratoxin α (OTα) as the starting material. The condensation reaction between protected amino acids and OTα, carried out in the presence of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC • HCl) and N-hydroxybenzotriazole (HOBt) as coupling agents, followed by deprotection and PTLC purification afforded OTA alanine, leucine, serine and tryptophane analogues in satisfactory yields (33-47%, based on OTα).
authors: Dipartimento di Scienze Farmaceutiche, Universita` della Calabria, Arcavacata di Rende 87036, Cosenza, Italy. p.plastina@unical.it
authors: Pierluigi
authors: P
authors: Plastina
authors: Alessia
authors: A
authors: Fazio
authors: Mohamed
authors: M
authors: Attya
authors: Giovanni
authors: G
authors: Sindona
authors: Bartolo
authors: B
authors: Gabriele
mesh_terms: D000409:Alanine / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009793:Ochratoxins / Q000138:chemical synthesis* / Q000737:chemistry; D012694:Serine / Q000737:chemistry; D014230:Triazoles / Q000737:chemistry
chemical_list: D009793:Ochratoxins; D014230:Triazoles; C025589:ochratoxin A; D012694:Serine; C011852:1-hydroxybenzotriazole; D000409:Alanine