title: Automated methods for the location of the boundaries of chromatographic peaks.
abstract: Several simple techniques are presented for the identification of the boundaries of chromatographic peaks. These methods provide a significant reduction in the time needed to perform the rapid, automatic calculation of the central peak moments and to evaluate the quality of a separation while improving the accuracy of the measurements of column efficiencies. It was found that the identification of the peak boundaries as functions of the peak widths and the examination of the slope of the signal to noise versus time plot are viable alternatives to a manual determination.
authors: Department of Chemistry, University of Tennessee, Knoxville, TN, USA.
authors: Paul G
authors: PG
authors: Stevenson
authors: Fabrice
authors: F
authors: Gritti
authors: Georges
authors: G
authors: Guiochon
mesh_terms: D002851:Chromatography, High Pressure Liquid; D001330:Electronic Data Processing / Q000379:methods*; D008962:Models, Theoretical; D009281:Naphthalenes; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted; D059629:Signal-To-Noise Ratio; D014052:Toluidines
chemical_list: D009281:Naphthalenes; D014052:Toluidines; C031721:naphthalene; C029370:4-toluidine