title: Concise review: limbal epithelial stem cell therapy: controversies and challenges.
abstract: Limbal epithelial stem cells (LESCs) are a population of stem cells responsible for maintenance and repair of the corneal surface. Injury and disease can result in a deficiency of these stem cells, the vision affecting condition called limbal stem cell deficiency (LSCD) in which the cornea becomes opaque, vascularized, and inflamed. Cultured LESC therapy was first described in 1997;29:19231932-19231932.and LESCs cultured from either patients or donors have been used to successfully treat LSCD. In this review, some of the challenges and controversies associated with cultured LESC therapy will be discussed including alternative stem cell sources.
authors: Department of Ocular Biology & Therapeutics, University College London Institute of Ophthalmology, London, United Kingdom. anna.ocallaghan@ucl.ac.uk
authors: Anna R
authors: AR
authors: O'Callaghan
authors: Julie T
authors: JT
authors: Daniels
mesh_terms: D018929:Cell Culture Techniques; D003316:Corneal Diseases / Q000473:pathology / Q000628:therapy*; D019573:Epithelium, Corneal / Q000166:cytology* / Q000637:transplantation; D006801:Humans; D016850:Limbus Corneae / Q000293:injuries / Q000473:pathology; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology*