title: Late corneal perforation with topical diclofenac sodium use after radiotherapy.
abstract: OBJECTIVE
  To report a case of spontaneous corneal perforation after radiotherapy connected with long-term use of topical 0.1% diclofenac sodium.
  
  
  METHODS
  A 31-year-old man presented with corneal melting and spontaneous corneal perforation. From his medical history, it was learned that he underwent radiotherapy for his nasopharyngeal carcinoma 25 months ago. He has been on artificial tears and topical 0.1% diclofenac sodium for 1 month for his dry eye. Diclofenac sodium was discontinued, and the corneal perforation site was sutured along with a bandage contact lens application.
  
  
  RESULTS
  Melting area disappeared, and stromal opacity was detected at the site of corneal perforation.
  
  
  CONCLUSIONS
  Use of long-term diclofenac sodium for dry eye after radiotherapy was possibly responsible for the spontaneous corneal perforation in our patient. It should always be borne in mind that topical diclofenac sodium should be used with caution in patients with compromised ocular surface.
authors: Department of Ophthalmology, Kahramanmaras State Hospital, Turkey. drsibeldemireltr@yahoo.com.tr
authors: Sibel
authors: S
authors: Demirel
authors: Ozge
authors: O
authors: Sarac
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D002277:Carcinoma; D057112:Corneal Perforation / Q000139:chemically induced*; D004008:Diclofenac / Q000009:adverse effects*; D015352:Dry Eye Syndromes / Q000150:complications; D006801:Humans; D008297:Male; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000532:radiotherapy; D012422:Rupture, Spontaneous / Q000139:chemically induced
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac