title: T cell polarization at the virological synapse.
abstract: Cell-to-cell spread of HIV-1 between CD4(+) T cells takes place at multimolecular structures called virological synapses. A defining feature of the virological synapse is polarization of viral assembly and budding at sites of T cell-T cell contact. Recent work is beginning to address how viral proteins are targeted to the virological synapse and the molecular mechanisms that regulate HIV-1 egress by cell-to-cell spread. This review discusses our current understanding of these processes and considers how T cell polarization during other forms of intercellular communication may provide insight into HIV-1 assembly and dissemination.
authors: MRC Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, W1T 4JF, UK.
authors: Clare
authors: C
authors: Jolly