title: Aortic stenosis and angiodysplastic gastrointestinal bleeding: Heyde's disease.
abstract: Obscure gastrointestinal (GI) bleeding can be a perplexing and difficult problem in elderly patients, especially if they are hemodynamically unstable. If aortic stenosis is also present, the cause of the GI bleeding may be explained. We present a 66-year-old man with a medical history of coronary artery disease who presented with acute GI bleeding. During his hospital course, the patient had a colonoscopy showing diffuse angiodysplasia and an echocardiogram showing severe aortic stenosis. This combination of angiodysplasia and aortic stenosis is known as Heyde's syndrome. It has been hypothesized that the aortic stenosis causes an acquired von Willebrand factor deficiency that leads to GI bleeding. Aortic valve replacement, when possible, can prevent recurrent GI bleeding in these cases, but medical decisions in these cases are complex and difficult.
authors: Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA. sameer.islam@ttuhsc.edu
authors: Sameer
authors: S
authors: Islam
authors: Ebtesam
authors: E
authors: Islam
authors: Cihan
authors: C
authors: Cevik
authors: Hosam
authors: H
authors: Attaya
authors: Mohammad
authors: M
authors: Otahbachi
authors: Kenneth
authors: K
authors: Nugent
mesh_terms: D000368:Aged; D016888:Angiodysplasia / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D001024:Aortic Valve Stenosis / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D003113:Colonoscopy / Q000009:adverse effects; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008297:Male; D014842:von Willebrand Diseases