title: A miniature mass spectrometer for liquid chromatography applications.
abstract: A miniature mass spectrometer capable of detecting analytes eluting from a high-performance liquid chromatography (HPLC) system is described and demonstrated for the first time. The entire instrument, including all pumps and the computer, is contained within a single enclosure that may be conveniently accommodated at the base of the HPLC stack. The microspray ion source, vacuum interface, ion guide, and quadrupole ion filter are all microengineered. These components are fabricated in batches using microelectromechanical systems (MEMS) techniques and considered to be consumables. When coupled to a standard HPLC system using an integrated passive split, the limit of detection for reserpine while scanning the full mass range is 5 ng on-column (1 pg of which is passed to the microspray). The mass range is m/z 100-800, and each spectrum is typically acquired at a rate of 1 scan per second.
authors: Microsaic Systems plc, Unit 2, GMS House, Boundary Rd, Woking, Surrey, GU21 5BX, UK.
authors: Andrew
authors: A
authors: Malcolm
authors: Steven
authors: S
authors: Wright
authors: Richard R A
authors: RR
authors: Syms
authors: Richard W
authors: RW
authors: Moseley
authors: Shane
authors: S
authors: O'Prey
authors: Neil
authors: N
authors: Dash
authors: Albert
authors: A
authors: Pegus
authors: Edward
authors: E
authors: Crichton
authors: Guodong
authors: G
authors: Hong
authors: Andrew S
authors: AS
authors: Holmes
authors: Alan
authors: A
authors: Finlay
authors: Peter
authors: P
authors: Edwards
authors: Simon E
authors: SE
authors: Hamilton
authors: Christopher J
authors: CJ
authors: Welch
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D013058:Mass Spectrometry / Q000295:instrumentation* / Q000379:methods; D055617:Micro-Electrical-Mechanical Systems / Q000295:instrumentation*; D008904:Miniaturization / Q000295:instrumentation*; D008956:Models, Chemical; D012110:Reserpine / Q000032:analysis; D012680:Sensitivity and Specificity
chemical_list: D012110:Reserpine