title: Differential involvement of GABAA and GABAB receptors in propofol self-administration in rats.
abstract: OBJECTIVE
  Propofol has shown abuse potential. The aim of the present study is to investigate the effects of GABA(A) antagonist and GABA(B) agonist on propofol reinforcement.
  
  
  METHODS
  Sprague-Dawley rats were trained to self-administer propofol at a dose of 1.7 mg/kg per infusion under a fixed ratio (FR1) schedule of reinforcement for 14 d. In a separate set of experiments, food-maintained self-administration under a fixed ratio (FR5) schedule and locomotor activities of Sprague-Dawley rats were examined.
  
  
  RESULTS
  GABA(A) receptor antagonist bicuculline (0.25 mg/kg, ip) significantly increased the number of injections and active responses. Pretreatment with GABA(B) receptor agonist baclofen (3 mg/kg, ip) significantly decreased the number of active responses and total infusions of propofol during the training session. Moreover, microinjection of baclofen (50 and 100 ng/side) into the ventral tegmental area (VTA) significantly decreased the number of active responses and total infusions of propofol. Neither baclofen (1-3 mg/kg, ip) nor bicuculline (0.25-1 mg/kg, ip) affected food-maintained responses or motor activities.
  
  
  CONCLUSIONS
  Propofol maintains its reward properties partially through GABA(A) receptor activation. Stimulation of GABA(B) receptors in VTA may counteract the reinforcing properties of propofol.
authors: Department of Anesthesiology of the 2nd Affiliated Hospital, Wenzhou Medical College, China.
authors: Bo
authors: B
authors: Yang
authors: Ben-fu
authors: BF
authors: Wang
authors: Miao-jun
authors: MJ
authors: Lai
authors: Fu-qiang
authors: FQ
authors: Zhang
authors: Xiao-wei
authors: XW
authors: Yang
authors: Wen-hua
authors: WH
authors: Zhou
authors: Qing-quan
authors: QQ
authors: Lian
mesh_terms: D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D000818:Animals; D001418:Baclofen / Q000494:pharmacology; D001640:Bicuculline / Q000494:pharmacology; D008297:Male; D008845:Microinjections; D015742:Propofol / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology*; D018080:Receptors, GABA-B / Q000187:drug effects / Q000502:physiology*; D012646:Self Administration
chemical_list: D018686:Anesthetics, Intravenous; D011963:Receptors, GABA-A; D018080:Receptors, GABA-B; D001418:Baclofen; D001640:Bicuculline; D015742:Propofol