title: Biocompatibility of acellular nerves of different mammalian species for nerve tissue engineering.
abstract: To explore the biocompatibility of acellular nerves of different mammalian species, for the acellular nerves derived from rats and rabbits, the morphology, immunocompatibility, and cytocompatibility with bone marrow stromal cells (BMSCs) were evaluated. The results indicated that the tridimensional architecture and main proteins of endoneurial tubes in both biomaterials were well retained. The nerve scaffolds did not show immunogenicity or cytotoxicity, but facilitated growth of BMSCs and secretion of neurotrophic factors in vitro. In conclusion, acellular nerves of different species possess favorable biocompatibility, and xenogenic acellular nerves combined with BMSCs have potential to replace allografts for peripheral nerve reconstruction.
authors: Department of Anatomy, College of Basic Medical Sciences, China Medical University, Shenyang, China.
authors: Hua
authors: H
authors: Jia
authors: Ying
authors: Y
authors: Wang
authors: Xiao-Jie
authors: XJ
authors: Tong
authors: Gui-Bo
authors: GB
authors: Liu
authors: Qi
authors: Q
authors: Li
authors: Li-Xin
authors: LX
authors: Zhang
authors: Xiao-Hong
authors: XH
authors: Sun
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology; D018929:Cell Culture Techniques; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D005260:Female; D006648:Histocompatibility / Q000187:drug effects; D008297:Male; D008422:Materials Testing / Q000379:methods*; D009417:Nerve Tissue / Q000166:cytology*; D009419:Nerve Tissue Proteins / Q000009:adverse effects* / Q000276:immunology / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D017154:Stromal Cells / Q000166:cytology / Q000187:drug effects; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000009:adverse effects*; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous
chemical_list: D009419:Nerve Tissue Proteins