title: The role of Th17 cells and regulatory T cells in Coxsackievirus B3-induced myocarditis.
abstract: IL-17-producing (Th17) and regulatory T (Treg) cells have been well established in the pathogenesis of many inflammatory diseases. To assess whether Th17 and Treg were altered in acute virus-induced myocarditis (AVMC) mice, we assessed Th17/Treg functions on different levels in AVMC. It was shown that the expression of splenic Th17 cells and Th17-related cytokines (IL-17A, IL-21) markedly increased. Interestingly, the expression of splenic Treg cells and Treg-related cytokines (TGF-β, IL-10) also significantly increased. Using neutralization of IL-17 in the AVMC, we found that Treg cells roughly decreased compared with isotype control mice. However, T cells and perforin dramatically increased, followed by a marked reduction in CVB3 replication. The results suggested that Th17 cells possibly contributed to viral replication through the action of Treg cells in mediating T cells and perforin response in AVMC.
authors: Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors: Yuquan
authors: Y
authors: Xie
authors: Ruizhen
authors: R
authors: Chen
authors: Xian
authors: X
authors: Zhang
authors: Ping
authors: P
authors: Chen
authors: Xujie
authors: X
authors: Liu
authors: Yeqing
authors: Y
authors: Xie
authors: Yong
authors: Y
authors: Yu
authors: Yingzhen
authors: Y
authors: Yang
authors: Yunzeng
authors: Y
authors: Zou
authors: Junbo
authors: J
authors: Ge
authors: Haozhu
authors: H
authors: Chen
mesh_terms: D000818:Animals; D003384:Coxsackievirus Infections / Q000235:genetics / Q000276:immunology* / Q000821:virology; D016207:Cytokines / Q000235:genetics / Q000276:immunology; D004195:Disease Models, Animal; D029822:Enterovirus B, Human / Q000276:immunology / Q000502:physiology*; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D009205:Myocarditis / Q000235:genetics / Q000276:immunology* / Q000821:virology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D058504:Th17 Cells / Q000276:immunology*
chemical_list: D016207:Cytokines