title: DNA repair gene polymorphisms and risk of chronic atrophic gastritis: a case-control study.
abstract: BACKGROUND
  Recent studies have reported associations of DNA repair pathway gene variants and risk of various cancers and precancerous lesions, such as chronic atrophic gastritis (CAG).
  
  
  METHODS
  A nested case-control study within the German population-based ESTHER cohort was conducted, including 533 CAG cases and 1054 controls. Polymorphisms in eleven DNA repair genes (APEX1, ERCC1, ERCC2/XPD, PARP1 and XRCC1), in CD3EAP/ASE-1 and PPP1R13L were analysed.
  
  
  RESULTS
  No association was disclosed for any of the analysed polymorphisms. Nor did stratified analyses according to ages < 65 and ≥ 65 years show any significant association with CAG risk.
  
  
  CONCLUSIONS
  The results of this large German case-control study do not reveal associations of DNA repair pathway polymorphisms and risk of CAG. On the basis of a large number of CAG cases, they do not support associations of DNA repair pathway SNPs with CAG risk, but suggest the need of larger studies to disclose or exclude potential weak associations, or of studies with full coverage of candidate genes.
authors: Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany. b.frank@dkfz.de
authors: Bernd
authors: B
authors: Frank
authors: Heiko
authors: H
authors: Müller
authors: Melanie Nicole
authors: MN
authors: Weck
authors: Norman
authors: N
authors: Klopp
authors: Thomas
authors: T
authors: Illig
authors: Elke
authors: E
authors: Raum
authors: Hermann
authors: H
authors: Brenner
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D004260:DNA Repair / Q000235:genetics*; D005260:Female; D005757:Gastritis, Atrophic / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D060005:Genotyping Techniques; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk