title: Cognitive decline and ischemic microlesions after coronary catheterization. A comparison to coronary artery bypass grafting.
abstract: BACKGROUND
  Postinterventional cognitive dysfunction (PICD) is a known complication of coronary artery bypass grafting (CABG). However, it is largely unknown whether PICD occurs after coronary catheterization.
  
  
  METHODS
  Neuropsychologic data were obtained from 37 patients who received coronary catheterization and 47 patients who underwent elective CABG at baseline and 3 months after the interventions. The outcomes were contrasted to 33 healthy volunteers, using analysis of covariance with baseline scores as covariates. Cerebral magnetic resonance imaging with diffusion-weighted imaging (DWI) sequences was performed in 30 catheter and 39 CABG patients 2 to 4 days after the procedures.
  
  
  RESULTS
  The rate of acute ischemic lesions amounted to 3.3% in the catheter group and to 17.9% in the CABG group. Postinterventional cognitive dysfunction was detected in 2 (of 10) tests in the catheter group as compared with the healthy controls (verbal memory: total recall, t = -2.61 (P = .005) and nonverbal memory, t = -2.60 [P = .005]). The CABG group showed PICD in 7 of 10 tests as compared with the healthy controls (statistics ranging from t = -1.95 [P = .027] to t = -5.14 [P < .001]). Scores of depression/anxiety and health-related quality of life were not associated with PICD (P > .05).
  
  
  CONCLUSIONS
  As compared with CABG, PICD and cerebral lesions appear to be substantially milder after coronary catheter intervention, but not negligible.
authors: Department of Neurology, Justus Liebig University Giessen, Germany.
authors: Niko
authors: N
authors: Schwarz
authors: Markus
authors: M
authors: Schoenburg
authors: Helge
authors: H
authors: Möllmann
authors: Sabrina
authors: S
authors: Kastaun
authors: Manfred
authors: M
authors: Kaps
authors: Georg
authors: G
authors: Bachmann
authors: Gebhard
authors: G
authors: Sammer
authors: Christian
authors: C
authors: Hamm
authors: Thomas
authors: T
authors: Walther
authors: Tibo
authors: T
authors: Gerriets
mesh_terms: D000368:Aged; D006328:Cardiac Catheterization / Q000009:adverse effects*; D003072:Cognition Disorders / Q000209:etiology*; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D003331:Coronary Vessels; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests