title: Connexin-dependent signaling in neuro-hormonal systems.
abstract: The advent of multicellular organisms was accompanied by the development of short- and long-range chemical signalling systems, including those provided by the nervous and endocrine systems. In turn, the cells of these two systems have developed mechanisms for interacting with both adjacent and distant cells. With evolution, such mechanisms have diversified to become integrated in a complex regulatory network, whereby individual endocrine and neuro-endocrine cells sense the state of activity of their neighbors and, accordingly, regulate their own level of functioning. A consistent feature of this network is the expression of connexin-made channels between the (neuro)hormone-producing cells of all endocrine glands and secretory regions of the central nervous system so far investigated in vertebrates. This review summarizes the distribution of connexins in the mammalian (neuro)endocrine systems, and what we know about the participation of these proteins on hormone secretion, the life of the producing cells, and the action of (neuro)hormones on specific targets. The data gathered since the last reviews on the topic are summarized, with particular emphasis on the roles of Cx36 in the function of the insulin-producing beta cells of the endocrine pancreas, and of Cx40 in that of the renin-producing juxta-glomerular epithelioid cells of the kidney cortex. This article is part of a Special Issue entitled: The Communicating junctions, composition, structure and characteristics.
authors: Department of Cell Physiology and Metabolism, University of Geneva Medical School, Switzerland.
authors: Ilaria
authors: I
authors: Potolicchio
authors: Valentina
authors: V
authors: Cigliola
authors: Silvia
authors: S
authors: Velazquez-Garcia
authors: Philippe
authors: P
authors: Klee
authors: Amina
authors: A
authors: Valjevac
authors: Dina
authors: D
authors: Kapic
authors: Esad
authors: E
authors: Cosovic
authors: Orhan
authors: O
authors: Lepara
authors: Almira
authors: A
authors: Hadzovic-Dzuvo
authors: Zakira
authors: Z
authors: Mornjacovic
authors: Paolo
authors: P
authors: Meda
mesh_terms: D000818:Animals; D017630:Connexins / Q000502:physiology*; D004298:Dopamine / Q000378:metabolism; D004703:Endocrine System / Q000502:physiology; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007672:Kidney Cortex / Q000378:metabolism; D008297:Male; D008954:Models, Biological; D009474:Neurons / Q000378:metabolism*; D010121:Oxytocin / Q000378:metabolism; D012083:Renin / Q000378:metabolism; D015398:Signal Transduction; D014667:Vasopressins / Q000378:metabolism
chemical_list: D017630:Connexins; D006728:Hormones; D007328:Insulin; D014667:Vasopressins; D007987:Gonadotropin-Releasing Hormone; D010121:Oxytocin; D012083:Renin; D004298:Dopamine