title: p53 and BCL-2 over-expression inversely correlates with histological differentiation in occupational ethmoidal intestinal-type sinonasal adenocarcinoma.
abstract: Despite their histological resemblance to colorectal adenocarcinoma, there is little information on the molecular events involved in the pathogenesis of intestinal-type sinonasal adenocarcinoma (ITACs). The aim of this paper is to evaluate the possible role of TP53 and Bcl-2 gene defects in ITAC by investigating the immunohistochemical expression of TP53 and Bcl-2 gene products in a group of ethmoidal ITACs associated with occupational exposure. A retrospective study on 15 patients with pathological diagnosis of primary ethmoidal ITAC was conducted. Representative formalin-fixed, paraffin wax-embedded block from each case was selected for immunohistochemical studies using the antibodies against p53 and Bcl-2. Clinical-pathological data were also correlated with the staining results. The results of immunohistochemical examination demonstrated that poorly differentiated cases showed a higher percentage of p53 and Bcl-2 expressing cells in comparison to well-differentiated cases. No correlation was found with other clinico-pathological parameters, including T, stage and relapses. The relationship between up-regulation of p53 and Bcl-2 and poorly differentiated ethmoidal adenocarcinoma suggests a role of these genes, in combination with additional genetic events, in the pathogenesis of ITAC.
authors: Department of Otorhinolaryngology, Marche Polytechnic University, Ancona, Italy.
authors: M
authors: M
authors: Re
authors: G
authors: G
authors: Magliulo
authors: P
authors: P
authors: Tarchini
authors: V
authors: V
authors: Mallardi
authors: C
authors: C
authors: Rubini
authors: A
authors: A
authors: Santarelli
authors: L
authors: L
authors: Lo Muzio
mesh_terms: D000230:Adenocarcinoma / Q000139:chemically induced* / Q000235:genetics* / Q000473:pathology; D000368:Aged; D014408:Biomarkers, Tumor; D004391:Dust; D005260:Female; D015870:Gene Expression / Q000502:physiology*; D019254:Genes, bcl-2 / Q000235:genetics*; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D007414:Intestinal Neoplasms / Q000139:chemically induced* / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009669:Nose Neoplasms / Q000139:chemically induced* / Q000235:genetics* / Q000473:pathology; D009784:Occupational Diseases / Q000139:chemically induced* / Q000235:genetics* / Q000473:pathology; D016273:Occupational Exposure / Q000009:adverse effects; D016612:Paraffin Embedding; D010255:Paranasal Sinus Neoplasms / Q000139:chemically induced* / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies; D016707:Tissue Fixation; D014934:Wood
chemical_list: D014408:Biomarkers, Tumor; D004391:Dust