title: Higher plasma renin activity is a risk factor for total mortality in older Japanese individuals: the Takahata study.
abstract: Plasma renin activity (PRA) is accepted as a marker for increased risk of cardiovascular diseases. However, the association between PRA and total mortality has not been fully explored in a general population. We here examined whether PRA is associated with increased total mortality in a general Japanese population. The participants of the Takahata study (3502 subjects; age, 62.5 ± 10.4 years), a population-based, longitudinal study of Japanese held from 2004 to 2006, were enrolled and followed up for up to 7 years. The incidence of death and causes of death were monitored annually to the end of 2010 (median follow-up, 2280 days). During the follow-up period, 143 subjects died. Kaplan-Meier analysis showed a significantly increased risk for total mortality in subjects with higher PRA (log-rank P < .001). Cox proportional hazard model analyses with adjustment for factors correlated with PRA (age, sex, weight, diastolic blood pressure, high-density lipoprotein cholesterol, uric acid, B-type natriuretic peptide, serum total protein, antihypertensive treatment, and diabetes) showed that higher PRA was associated with increased total mortality in linear regression models (per 1 increase in log 10 × PRA [nanograms per milliliter per hour]: hazard ratio, 2.12; 95% confidence interval, 1.47-3.06), between groups of patients stratified by quartiles of PRA (highest vs lowest quartile: 2.63, 1.57-4.41) and in subjects with high (≥ 2.0 ng/[mL h]) vs low (<2.0 ng/[mL h]) PRA (1.97, 1.37-2.83). Higher PRA was a significant and independent risk factor for increased total mortality in this Japanese population and may be a marker for subjects at an increased risk of total mortality.
authors: Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University School of Medicine, Yamagata, Japan. mdaimon@med.id.yamagata-u.ac.jp
authors: Makoto
authors: M
authors: Daimon
authors: Tsuneo
authors: T
authors: Konta
authors: Toshihide
authors: T
authors: Oizumi
authors: Shigeru
authors: S
authors: Karasawa
authors: Wataru
authors: W
authors: Kaino
authors: Kaoru
authors: K
authors: Takase
authors: Yumi
authors: Y
authors: Jimbu
authors: Kiriko
authors: K
authors: Wada
authors: Wataru
authors: W
authors: Kameda
authors: Shinji
authors: S
authors: Susa
authors: Takafumi
authors: T
authors: Saito
authors: Isao
authors: I
authors: Kubota
authors: Takamasa
authors: T
authors: Kayama
authors: Takeo
authors: T
authors: Kato
mesh_terms: D001794:Blood Pressure / Q000502:physiology; D001798:Blood Proteins / Q000032:analysis; D001835:Body Weight / Q000502:physiology; D002784:Cholesterol / Q000097:blood; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009026:Mortality; D020097:Natriuretic Peptide, Brain / Q000097:blood; D011446:Prospective Studies; D012083:Renin / Q000097:blood*; D014527:Uric Acid / Q000097:blood
chemical_list: D001798:Blood Proteins; D020097:Natriuretic Peptide, Brain; D014527:Uric Acid; D002784:Cholesterol; D012083:Renin