title: Prenatal exposure to polybrominated diphenyl ether flame retardants and neonatal thyroid-stimulating hormone levels in the CHAMACOS study.
abstract: Studies published in the last 3 decades have demonstrated global human exposure to polybrominated diphenyl ether (PBDE) flame retardants. A growing body of literature suggests that PBDEs may disrupt thyroid hormone homeostasis. Although thyroid hormones play an essential role in brain development, few studies have investigated relations between prenatal exposure to PBDEs and neonatal thyroid hormone levels, and none have measured thyroid-stimulating hormone (TSH) levels in neonates. The authors measured 10 PBDE congeners in serum collected between October 1999 and October 2000 from 289 pregnant women living in California's Salinas Valley and abstracted TSH levels from their children's medical records. Individual PBDE congeners showed null or weak nonsignificant inverse relations with neonatal TSH. Total serum PBDE was not associated with neonatal TSH (β = 0.00, 95% confidence interval: -0.06, 0.06). Except for brominated diphenyl ether 153, a higher serum PBDE level was related to elevated odds of high TSH (≥80th percentile), but associations were not statistically significant. Associations were not modified by infant sex, age at TSH measurement, maternal serum polychlorinated biphenyl concentration, or mode of delivery. Results were robust to sensitivity analysis. The authors found no conclusive evidence that prenatal exposure to PBDEs at levels similar to those of the general US population is related to neonatal TSH.
authors: Center for Environmental Research and Children’s Health, School of Public Health, University of California-Berkeley, 1995 University Avenue, Berkeley, CA 94704-7392, USA. chevrier@berkeley.edu
authors: Jonathan
authors: J
authors: Chevrier
authors: Kim G
authors: KG
authors: Harley
authors: Asa
authors: A
authors: Bradman
authors: Andreas
authors: A
authors: Sjödin
authors: Brenda
authors: B
authors: Eskenazi
mesh_terms: D000293:Adolescent; D000328:Adult; D001724:Birth Weight; D002140:California; D005260:Female; D005411:Flame Retardants / Q000032:analysis*; D005865:Gestational Age; D055768:Halogenated Diphenyl Ethers / Q000097:blood*; D015438:Health Behavior; D006801:Humans; D008297:Male; D018811:Maternal Exposure; D008875:Middle Aged; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000097:blood*; D012959:Socioeconomic Factors; D013972:Thyrotropin / Q000097:blood*; D055815:Young Adult
chemical_list: D005411:Flame Retardants; D055768:Halogenated Diphenyl Ethers; D013972:Thyrotropin