title: Twelve-year experience with Hinman-Allen syndrome at a single center.
abstract: OBJECTIVE
  To report the long-term follow-up results of patients with Hinman-Allen syndrome (HAS) at our institution.
  
  
  METHODS
  The data from 22 children with HAS were retrospectively analyzed. The patients were followed up every 3-6 months with serial physical examinations, voiding charts, urine culture, postvoid residual urine volume determination, serum creatinine measurement, and urinary imaging. The follow-up time was calculated from the day of the first visit to the day of the latest dimercaptosuccinic acid scan. Urotherapy, pharmacotherapy, clean intermittent catheterization, biofeedback therapy, and surgery were performed sequentially and/or combined, depending on the disease course. Renal deterioration was defined as any presence of a new scar or cortical thinning compared with the findings from the first dimercaptosuccinic acid scan. Upper urinary tract deterioration was defined as the persistence or progression of hydronephrosis on ultrasonography.
  
  
  RESULTS
  The mean age at referral was 9.18 ± 3.36 years (range 2-14), and the mean follow-up period was 80.90 ± 19.57 months (range 54-144). Conservative therapy resulted in improvement of the bladder function in 14 patients; however, 8 patients required surgery owing to failure of this approach. Asymptomatic bacteriuria developed in one half of the children (n = 11, 50%), and in 6 (22.7%), ≥1 febrile urinary tract infection developed. None of the patients had upper urinary tract deterioration; however, renal deterioration developed in 3 patients (13.6%). The mean creatinine levels had remained stable at the end of the follow-up.
  
  
  CONCLUSIONS
  Close follow-up at a single institution and proactive treatment resulted in successful stabilization of HAS in most of our children with HAS.
authors: 2nd Urology Department, Sisli Etfal Training and Research Hospital, Istanbul, Turkey. selcuksilay@gmail.com
authors: Mesrur Selcuk
authors: MS
authors: Silay
authors: Orhan
authors: O
authors: Tanriverdi
authors: Tuna
authors: T
authors: Karatag
authors: Gul
authors: G
authors: Ozcelik
authors: Kaya
authors: K
authors: Horasanli
authors: Cengiz
authors: C
authors: Miroglu
mesh_terms: D000293:Adolescent; D001521:Behavior Therapy; D001676:Biofeedback, Psychology; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D053207:Diurnal Enuresis / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006869:Hydronephrosis / Q000000981:diagnostic imaging; D057928:Intermittent Urethral Catheterization; D007668:Kidney / Q000000981:diagnostic imaging; D008297:Male; D053206:Nocturnal Enuresis / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D011379:Prognosis; D011859:Radiography; D011877:Radionuclide Imaging; D051437:Renal Insufficiency / Q000517:prevention & control; D012189:Retrospective Studies; D013577:Syndrome; D014463:Ultrasonography; D001743:Urinary Bladder / Q000000981:diagnostic imaging; D014552:Urinary Tract Infections / Q000503:physiopathology; D014563:Urodynamics
chemical_list: D003404:Creatinine