title: In vivo response of bone defects filled with PMMA in an ovine model.
abstract: The use of PMMA cement is common in arthroplasty for cemented fixation and defect filling. Concerns remain regarding effects of cement curing temperature on the viability of cancellous bone. In this study we filled surgically-created defects (mean volume 0.585±0.251 mL) in the cancellous bone of the distal femur and proximal tibia of 6 sheep with PMMA and measured temperature changes in surrounding bone whilst the cement cured, using 3 thermocouples per defect. Animals were euthanised at 3 (n=3) and 12 (n=3) weeks postoperatively and the bone-cement interface assessed histologically. Despite mean maximum temperatures of 49.3±10.2 °C (range: 40.9 °C - 82.2 °C) thermonecrosis was not a common histological feature at either timepoint. The exposure of bone to high cement temperatures in this study has not led to bone necrosis and/or tissue damage.
authors: Malabar Orthopaedic Institute, and Monash University, Melbourne, Australia.
authors: Stephen
authors: S
authors: McMahon
authors: Gabrielle
authors: G
authors: Hawdon
authors: John
authors: J
authors: Baré
authors: Yan
authors: Y
authors: Yu
authors: Nicky
authors: N
authors: Bertollo
authors: William R
authors: WR
authors: Walsh
mesh_terms: D000818:Animals; D001843:Bone Cements / Q000494:pharmacology*; D001861:Bone Regeneration / Q000187:drug effects* / Q000502:physiology; D004195:Disease Models, Animal; D005269:Femur / Q000187:drug effects / Q000473:pathology; D006358:Hot Temperature / Q000009:adverse effects*; D008297:Male; D010020:Osteonecrosis / Q000209:etiology*; D019904:Polymethyl Methacrylate / Q000494:pharmacology*; D011474:Prosthesis Design; D012756:Sheep / Q000502:physiology*; D013977:Tibia / Q000187:drug effects / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology
chemical_list: D001843:Bone Cements; D019904:Polymethyl Methacrylate