title: Antibody response in MOG(35-55) induced EAE.
abstract: Neurological deficit in experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis is widely considered to be a consequence of synergistic T and B cell responses to central nervous system (CNS) antigens. We show that mice immunized with encephalitogenic myelin oligodendrocyte glycoprotein (MOG(35-55)) peptide develop significant serum levels of anti-MOG antibodies in parallel with disease progression. Furthermore, EAE mice developed antibodies against DNA and RNA, a serological hallmark observed in autoimmune diseases such as systemic lupus erythematosus. The presence of anti-nucleic responsive B cells and antibodies during EAE may highlight a previously unappreciated mechanism in the pathogenesis of CNS autoimmunity.
authors: Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.
authors: Patrice H
authors: PH
authors: Lalive
authors: Nicolas
authors: N
authors: Molnarfi
authors: Mahdia
authors: M
authors: Benkhoucha
authors: Martin S
authors: MS
authors: Weber
authors: Marie-Laure
authors: ML
authors: Santiago-Raber
mesh_terms: D000818:Animals; D000974:Antibodies, Antinuclear / Q000096:biosynthesis* / Q000097:blood; D000918:Antibody Specificity; D001323:Autoantibodies / Q000096:biosynthesis* / Q000097:blood; D016175:B-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D004247:DNA / Q000276:immunology; D018450:Disease Progression; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006023:Glycoproteins / Q000008:administration & dosage* / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D063308:Myelin-Oligodendrocyte Glycoprotein; D010446:Peptide Fragments / Q000008:administration & dosage* / Q000276:immunology*; D012313:RNA / Q000276:immunology; D013997:Time Factors
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D006023:Glycoproteins; D063308:Myelin-Oligodendrocyte Glycoprotein; D010446:Peptide Fragments; C445081:myelin oligodendrocyte glycoprotein (35-55); D012313:RNA; D004247:DNA