title: From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications.
abstract: This article reviews the regulation of production of RBCs at several levels. We focus on the regulated expansion of burst-forming unit-erythroid erythroid progenitors by glucocorticoids and other factors that occur during chronic anemia, inflammation, and other conditions of stress. We also highlight the rapid production of RBCs by the coordinated regulation of terminal proliferation and differentiation of committed erythroid colony-forming unit-erythroid progenitors by external signals, such as erythropoietin and adhesion to a fibronectin matrix. We discuss the complex intracellular networks of coordinated gene regulation by transcription factors, chromatin modifiers, and miRNAs that regulate the different stages of erythropoiesis.
authors: Whitehead Institute for Biomedical Research, Cambridge, MA, USA.
authors: Shilpa M
authors: SM
authors: Hattangadi
authors: Piu
authors: P
authors: Wong
authors: Lingbo
authors: L
authors: Zhang
authors: Johan
authors: J
authors: Flygare
authors: Harvey F
authors: HF
authors: Lodish
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D002843:Chromatin / Q000378:metabolism; D044127:Epigenesis, Genetic; D004912:Erythrocytes / Q000166:cytology* / Q000378:metabolism; D015672:Erythroid Precursor Cells / Q000166:cytology* / Q000378:metabolism; D004920:Erythropoiesis; D004921:Erythropoietin / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism; D008954:Models, Biological; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D035683:MicroRNAs; D004921:Erythropoietin