title: Tissue-based molecular markers for renal cell carcinoma.
abstract: Since the introduction of targeted therapies in renal cell carcinoma (RCC), more individualized treatment options have become available. Molecular markers might support treatment planning due to more accurate individual risk stratification. Current molecular markers in RCC were reviewed to elucidate clinical impact and future perspectives. An English-language literature review of the Medline database (1990 to September 2010) of published data on tissue-based molecular markers and RCC was undertaken. Histological types, clinical and oncological behaviour are variable in renal masses. Molecular markers offer potential for additional information in tumour detection and diagnosis, prognostic and predictive values, as well as determination of therapeutic targets. Investigations on molecular biomarkers in RCC include hypoxia inducible factor (HIF-α), vascular endothelial growth factor (VEGF), carbonic anhydrase IX (CAIX), mammalian target of rapamycin (mTOR), survivin, B7-H1, p53, matrix metalloproteinases (MMP), Insulin-like growth factor II mRNA-binding protein 3 (IMP3), Ki-67, C-reactive protein (CRP), Vimentin, Fascin, platelet count, hemoglobin level and combinations of these factors. Although some markers offer promising results, utilization in daily practice is compromised due to limited specificity, predictive accuracy and tumour histology variablity. There is an imminent need for novel molecular markers that allow accurate histologic and biologic classification of RCC to improve upon current outcomes. It is very likely that a panel of molecular markers will be used to achieve a sufficient degree of certainty in order to guide clinical decisions. A large concerted effort is required to advance the field of RCC molecular marker through systematic discovery, verification, and validation.
authors: Department of Urology, University of Hamburg, Hamburg, Germany.
authors: M
authors: M
authors: Rink
authors: F K H
authors: FK
authors: Chun
authors: B
authors: B
authors: Robinson
authors: M
authors: M
authors: Sun
authors: P I
authors: PI
authors: Karakiewicz
authors: K
authors: K
authors: Bensalah
authors: M
authors: M
authors: Fisch
authors: D S
authors: DS
authors: Scherr
authors: R K
authors: RK
authors: Lee
authors: V
authors: V
authors: Margulis
authors: S F
authors: SF
authors: Shariat
mesh_terms: D060890:B7-H1 Antigen / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism; D002256:Carbonic Anhydrases / Q000378:metabolism; D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000201:enzymology / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism; D015853:Cysteine Proteinase Inhibitors / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism; D007335:Insulin-Like Growth Factor II / Q000378:metabolism; D019394:Ki-67 Antigen / Q000378:metabolism; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000201:enzymology / Q000378:metabolism*; D020781:Matrix Metalloproteinase 1 / Q000378:metabolism; D008840:Microfilament Proteins / Q000378:metabolism; D010976:Platelet Count; D011379:Prognosis; D016601:RNA-Binding Proteins / Q000378:metabolism; D000077022:Survivin; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism
chemical_list: D060890:B7-H1 Antigen; C107489:BIRC5 protein, human; D014408:Biomarkers, Tumor; D002352:Carrier Proteins; D015853:Cysteine Proteinase Inhibitors; C497442:HIF1A protein, human; D006454:Hemoglobins; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; C498780:IGF2BP3 protein, human; D051034:Inhibitor of Apoptosis Proteins; D019394:Ki-67 Antigen; D008840:Microfilament Proteins; D016601:RNA-Binding Proteins; D000077022:Survivin; D016159:Tumor Suppressor Protein p53; D042461:Vascular Endothelial Growth Factor A; D014746:Vimentin; C020324:fascin; D007335:Insulin-Like Growth Factor II; D002097:C-Reactive Protein; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases; D020781:Matrix Metalloproteinase 1; D002256:Carbonic Anhydrases