title: Non-invasive radiofrequency-induced targeted hyperthermia for the treatment of hepatocellular carcinoma.
abstract: Targeted biological therapies for hepatocellular cancer have shown minimal improvements in median survival. Multiple pathways to oncogenesis leading to rapid development of resistance to such therapies is a concern. Non-invasive radiofrequency field-induced targeted hyperthermia using nanoparticles is a radical departure from conventional modalities. In this paper we underscore the need for innovative strategies for the treatment of hepatocellular cancer, describe the central paradigm of targeted hyperthermia using non-invasive electromagnetic energy, review the process of characterization and modification of nanoparticles for the task, and summarize data from cell-based and animal-based models of hepatocellular cancer treated with non-invasive RF energy. Finally, future strategies and challenges in bringing this modality from bench to clinic are discussed.
authors: Department of Surgical Oncology, Rice University, Houston, TX 77030, USA.
authors: Mustafa
authors: M
authors: Raoof
authors: Steven A
authors: SA
authors: Curley