title: [In vitro comparison of transdermal characteristics of xiaoyu ointment and xiaoyu plaster].
abstract: OBJECTIVE
  Through the comparison of Xiaoyu ointment and xiaoyu plaster by in vitro transdermal demonstrate, to demonstrate the scientificity and feasibility of reformed formulation.
  
  
  METHODS
  The improved Franz diffusion cells and in vitro rabbit skin were used in vitro penetration experiment with emodin as an indicator of penetration rate quantitated by HPLC.
  
  
  RESULTS
  The cumulative penetration rate of emodin in Xiaoyu ointment fit the model of Weibull distribution, while the cumulative penetration rate of emodin in Xiaoyu plaster fit the model of Density equation. Take emodin as an index,the transdermal rate in Xiaoyu plaster was 1.93 times as Xiaoyu ointment, and the total penetrated amount was 2.84 times as Xiaoyu ointment. The results showed that the emodin of xiaoyu plaster reserved in the skin were 3.95 times more than the ointment.
  
  
  CONCLUSIONS
  The penetration rate, total penetrated amount and the reserves in the skin of Xiaoyu plaster were better than the ointment, and the transdermal dosage form was better than the original form.
authors: Hunan University of Traditional Chinese Medicine, Changsha 410007, China.
authors: Chuncheng
authors: C
authors: Zhu
authors: Liping
authors: L
authors: Peng
authors: Benchao
authors: B
authors: Chen
authors: Qun
authors: Q
authors: He
authors: Qingbo
authors: Q
authors: Wen
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D009824:Ointments / Q000493:pharmacokinetics*; D011817:Rabbits; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption
chemical_list: D009824:Ointments