title: Synthesis and characterization of bovine serum albumin-coated nanocapsules loaded with indocyanine green as potential multifunctional nanoconstructs.
abstract: We have synthesized and characterized bovine serum albumin (BSA)-coated polymeric nanocapsules (NCs) loaded with indocyanine green (ICG), an FDA-approved near infrared chromophore. Poly(allylamine) hydrochloride was electrostatically crosslinked with phosphate anions to form nanoconstructs encapsulating ICG. BSA was conjugated onto the polymeric NCs via glutaraldehyde. BSA-coated ICG-containing nanocapsules (BSA-ICG NCs) were characterized by FTIR and optical spectroscopy, SEM, and zeta-potential measurements. Using normal human endocervical epithelial cells, we demonstrate the effectiveness of BSA-ICG NCs for intracellular optical imaging in vitro. These nanoconstructs may potentially serve as a multifunctional platform for combined optical imaging, phototherapy, and drug delivery.
authors: Dept. of Bioengineering, University of California, Riverside, Riverside, CA 92521, USA.
authors: Bongsu
authors: B
authors: Jung
authors: Bahman
authors: B
authors: Anvari
mesh_terms: D002460:Cell Line; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000295:instrumentation; D006801:Humans; D007208:Indocyanine Green / Q000737:chemistry*; D053769:Nanocapsules / Q000737:chemistry*; D010316:Particle Size; D012710:Serum Albumin, Bovine / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D053769:Nanocapsules; D012710:Serum Albumin, Bovine; D007208:Indocyanine Green