title: Synthesis of some novel D-glucuronic acid acetylated derivatives as potential anti-tumor agents.
abstract: A structurally diverse series of Δ(4,5) -uronamide derivatives have been chemically synthesized starting from D-glucuronic acid itself by means of acetylation, activation, amide bond formation and base-catalyzed elimination protocols. Structure elucidation for all products along with optimization of the synthetic steps is described. The synthesized compounds were evaluated for their in-vitro anti-tumor activity against MCF-7, TK-10 and UACC-62 cell lines. The compounds 5, 11, 13, 15 and 16 were the most active against TK-10 cell line. On the other hand, the most active compounds against the MCF-7 cell line were 11 and 15. However, compounds 5, 7, 11, 13, 15 and 16 were the most active against the UACC-62 cell line.
authors: Chemistry of Natural and Microbial Products Department, National Research Center, Dokki, Cairo, Egypt. nzhawy7@yahoo.com
authors: Ahmed O H
authors: AO
authors: El-Nezhawy
authors: Frady G
authors: FG
authors: Adly
authors: Ahmed F
authors: AF
authors: Eweas
authors: Atef G
authors: AG
authors: Hanna
authors: Yehya M
authors: YM
authors: El-Kholy
authors: Shahenaz H
authors: SH
authors: El-Sayed
authors: Tarek B A
authors: TB
authors: El-Naggar
mesh_terms: D000107:Acetylation; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D005965:Glucuronates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D005965:Glucuronates