title: Idiopathic interstitial lung disease with anti-SSA antibody.
abstract: OBJECTIVE
  Consensus is lacking on the immunological tests to perform for diagnosis of interstitial lung diseases (ILDs). In particular, the value of detecting anti-SSA antibody in this context is unknown. We aimed to determine whether the detection of anti-SSA antibody in patients with ILD can identify a subgroup of patients with CTD.
  
  
  METHODS
  We compared the characteristics of patients with newly diagnosed apparently idiopathic ILD with anti-SSA antibody [anti-SSA(+) group] and without anti-SSA antibody (control group). RESULTS; Anti-SSA(+) patients (n = 15) more often had extra-respiratory signs (xerostomia and ocular dryness), auto-immune features, a CT scan pattern of non-specific interstitial pneumonia and more severe lung function alteration than controls (n = 30). Of patients who were anti-SSA(+), 2 met the criteria for SS and 13 (86%) of 15 met the criteria for the diagnosis of undifferentiated CTD.
  
  
  CONCLUSIONS
  Our results suggest that identification of anti-SSA antibody in patients with early ILD can reveal a specific subgroup of patients with more ground glass opacity and more severe lung function impairment than those without anti-SSA antibody.
authors: Pneumology A Department, Bichat-Claude Bernard Hospital, Paris, France. bruno.crestani@bch.aphp.fr
authors: Jean-François
authors: JF
authors: Boitiaux
authors: Marie-Pierre
authors: MP
authors: Debray
authors: Pascale
authors: P
authors: Nicaise-Roland
authors: Homa
authors: H
authors: Adle-Biassette
authors: Claire
authors: C
authors: Danel
authors: Christine
authors: C
authors: Clérici
authors: Michel
authors: M
authors: Aubier
authors: Xavier
authors: X
authors: Mariette
authors: Jacques
authors: J
authors: Cadranel
authors: Bruno
authors: B
authors: Crestani
mesh_terms: D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007159:Immunologic Tests / Q000379:methods; D017563:Lung Diseases, Interstitial / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D000974:Antibodies, Antinuclear; D015415:Biomarkers; C035356:SS-A antibodies