title: Gold(I)-catalyzed formation of 3-pyrazolines through cycloaddition of diaziridine to alkynes.
abstract: This work reports the high-yield formation of pyrazoline derivatives mediated by gold(I) catalysts. The reaction utilizes a diaziridine, which has seen only limited usage in organic methodology. Mechanistic studies suggest a gold-mediated opening of the diazridine ring, alkyne insertion, and finally an intramolecular hydroamination to furnish the product.
authors: Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA.
authors: David A
authors: DA
authors: Capretto
authors: Chad
authors: C
authors: Brouwer
authors: Catherine B
authors: CB
authors: Poor
authors: Chuan
authors: C
authors: He
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D003978:Diazomethane / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis*
chemical_list: D000480:Alkynes; D011720:Pyrazoles; D003978:Diazomethane; D006046:Gold