title: Bioresorption and degradation of biomaterials.
abstract: The human body is a composite structure, completely constructed of biodegradable materials. This allows the cells of the body to remove and replace old or defective tissue with new material. Consequently, artificial resorbable biomaterials have been developed for application in regenerative medicine. We discuss here advantages and disadvantages of these bioresorbable materials for medical applications and give an overview of typically used metals, ceramics and polymers. Methods for the quantification of bioresorption in vitro and in vivo are described. The next challenge will be to better understand the interface between cell and material and to use this knowledge for the design of “intelligent” materials that can instruct the cells to build specific tissue geometries and degrade in the process.
authors: Debarun
authors: D
authors: Das
authors: Ziyang
authors: Z
authors: Zhang
authors: Thomas
authors: T
authors: Winkler
authors: Meenakshi
authors: M
authors: Mour
authors: Christina
authors: C
authors: Gunter
authors: Michael
authors: M
authors: Morlock
authors: Hans-Gunther
authors: HG
authors: Machens
authors: Arndt F
authors: AF
authors: Schilling
mesh_terms: D020341:Absorbable Implants; D000042:Absorption; D000327:Adsorption; D001672:Biocompatible Materials / Q000737:chemistry*; D001826:Body Fluids / Q000737:chemistry*; D008422:Materials Testing
chemical_list: D001672:Biocompatible Materials