title: Attribution of human papillomavirus types to cervical intraepithelial neoplasia and invasive cancers in Southern China.
abstract: The attribution of individual human papillomavirus (HPV) types to cervical neoplasia, especially intraepithelial lesions, varies ethnogeographically. Population-specific data are required for vaccine cost-effectiveness assessment and type replacement monitoring. HPV was detected from 2,790 Chinese women (444 invasive cervical cancers [ICC], 772 cervical intraepithelial neoplasia [CIN] grade 3, 805 CIN2 and 769 CIN1. The attribution of each HPV type found in multiple-type infections was approximated by the fractional contribution approach. Multiple-type infection was common and correlated inversely with lesion severity (54.7% for CIN1, 48.7% for CIN2, 46.2% for CIN3, 27.5% for ICC). Vaccine-covered high-risk types (HPV16/18) attributed to 59.5% of squamous cell carcinoma, 78.6% of adenocarcinoma, 35.9% of CIN3, 18.4% of CIN2 and 7.4% of CIN1. Distinct features compared to worldwide were a higher attribution of HPV52 and HPV58, and a much lower attribution of HPV45. Inclusion of HPV52 and HPV58 in future vaccines would provide the highest marginal increase in coverage with 11.7% for squamous cell carcinoma, 14.4% for CIN3, 22.6% for CIN2 and 17.7% for CIN1. The attribution of HPV types in southern China is different from elsewhere, which should be considered in prioritizing HPV types for vaccine and screening assay development.
authors: Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, People's Republic of China. paulkschan@cuhk.edu.hk
authors: Paul K S
authors: PK
authors: Chan
authors: Tak-Hong
authors: TH
authors: Cheung
authors: Wai-Hon
authors: WH
authors: Li
authors: Mei Y
authors: MY
authors: Yu
authors: May Y M
authors: MY
authors: Chan
authors: So-Fan
authors: SF
authors: Yim
authors: Wendy C S
authors: WC
authors: Ho
authors: Apple C M
authors: AC
authors: Yeung
authors: King-Man
authors: KM
authors: Ho
authors: H K
authors: HK
authors: Ng
mesh_terms: D052685:Alphapapillomavirus / Q000145:classification*; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000821:virology*; D053918:Papillomavirus Vaccines; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000821:virology*; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology / Q000821:virology*
chemical_list: D053918:Papillomavirus Vaccines