title: Prospective seroepidemiologic study of human papillomavirus and other risk factors in cervical cancer.
abstract: BACKGROUND
  Several sexually transmitted infections (STI) have been reported to interact with human papillomavirus (HPV) in the etiology of cervical cancer. A large cohort study is required to obtain a both unbiased and stable estimate of their effects.
  
  
  METHODS
  Four major biobanks in the Nordic Countries containing samples from about 1,000,000 subjects were linked with nation-wide cancer registries. Serum samples from 604 women with invasive cervical cancer (ICC) diagnosed on average 10 years after sampling and 2,980 matched control women were retrieved and analyzed with serology for key STI.
  
  
  RESULTS
  Exposure to HPV16 was the strongest risk factor for cervical cancer [OR = 2.4; 95% confidence interval (CI), 2.0-3.0], particularly for squamous cell carcinoma (OR = 2.9; 95% CI, 2.2-3.7). HPV18 was strongly associated with increased risk for adenocarcinoma (OR = 2.3; 95% CI, 1.3-4.1). Baseline seropositivity for HPV16 did not confer any increased risk for HPV18 DNA-positive cancer and conversely HPV18 seropositivity had no association with HPV16 DNA-positive cancers. HPV6 had no effect on its own (OR = 1.1; 95% CI, 0.9-1.3), but had an antagonistic effect on the risk conferred by HPV16 (P < 0.01). Herpes simplex virus 2 had little or no association (OR = 1.1; 95% CI, 0.8-1.4). Previous exposure to Chlamydia trachomatis, as indicated by serum antibodies, had a strongly increased risk for cervical cancer (OR = 1.9; 95% CI, 1.5-2.3).
  
  
  CONCLUSIONS
  A large prospective study has assessed the role of different STIs in cervical cancer.
  
  
  CONCLUSIONS
  Prospective evidence supports cofactor role of some STI in cervical cancer.
authors: Department of Medical Epidemiology & Biostatistics, Karolinska Institutet, Stockholm, Sweden.
authors: Lisen
authors: L
authors: Arnheim Dahlström
authors: Kristin
authors: K
authors: Andersson
authors: Tapio
authors: T
authors: Luostarinen
authors: Steinar
authors: S
authors: Thoresen
authors: Helga
authors: H
authors: Ögmundsdottír
authors: Laufey
authors: L
authors: Tryggvadottír
authors: Fredrik
authors: F
authors: Wiklund
authors: Gry B
authors: GB
authors: Skare
authors: Carina
authors: C
authors: Eklund
authors: Kia
authors: K
authors: Sjölin
authors: Egil
authors: E
authors: Jellum
authors: Pentti
authors: P
authors: Koskela
authors: Göran
authors: G
authors: Wadell
authors: Matti
authors: M
authors: Lehtinen
authors: Joakim
authors: J
authors: Dillner
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D015331:Cohort Studies; D005260:Female; D052162:Human papillomavirus 16 / Q000302:isolation & purification; D052161:Human papillomavirus 18 / Q000302:isolation & purification; D006801:Humans; D007055:Iceland / Q000453:epidemiology; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology; D011446:Prospective Studies; D012307:Risk Factors; D012537:Scandinavian and Nordic Countries / Q000453:epidemiology; D016036:Seroepidemiologic Studies; D012749:Sexually Transmitted Diseases / Q000453:epidemiology* / Q000821:virology; D014412:Tumor Virus Infections / Q000150:complications / Q000453:epidemiology*; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000821:virology; D055815:Young Adult