title: Novel use of prasugrel for intracranial stent thrombosis.
abstract: Dual antiplatelet therapy is established for prevention of stent thrombosis in cardiac patients, and widely utilized in neurointerventional stent cases. Aspirin and clopidogrel are typically synergistic. We present a case of clopidogrel resistance due to genetic polymorphism resulting in acute stent thrombosis during elective stent-assisted coiling, with novel use of prasugrel as an alternative platelet inhibitor in the neurovascular setting.
authors: Department of Interventional Neuroradiology/Endovascular Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. tleslie-mazwi@partners.org
authors: Thabele M
authors: TM
authors: Leslie-Mazwi
authors: Ronil V
authors: RV
authors: Chandra
authors: Daniel C
authors: DC
authors: Oh
authors: Raul G
authors: RG
authors: Nogueira
mesh_terms: D006801:Humans; D020767:Intracranial Thrombosis / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D008875:Middle Aged; D010879:Piperazines / Q000008:administration & dosage*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D000068799:Prasugrel Hydrochloride; D011859:Radiography; D015607:Stents / Q000009:adverse effects*; D013876:Thiophenes / Q000008:administration & dosage*
chemical_list: D010879:Piperazines; D010975:Platelet Aggregation Inhibitors; D013876:Thiophenes; D000068799:Prasugrel Hydrochloride