title: Thrombotic microangiopathy induced by long-term interferon-β therapy for multiple sclerosis: a case report.
abstract: We report the case of a 53-year-old woman treated for 8 years with Betaferon® (interferon-β-1b), who developed mild renal failure with hypertension, proteinuria and glomerular hematuria. Kidney biopsy was consistent with thrombotic microangiopathy (TMA). Considering the strong evidence of interferon-α causing TMA and the numerous immunomodulatory activities shared by INF-α and -β, we incriminated Betaferon as the etiological agent of TMA in our patient. To our knowledge, it is the first time such an association has been published.
authors: Departments of Nephrology, Cliniques Universitaires Saint Luc, Université Catholique de Louvain, Brussels, Belgium.
authors: A
authors: A
authors: Broughton
authors: J-P
authors: JP
authors: Cosyns
authors: M
authors: M
authors: Jadoul
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000276:Adjuvants, Immunologic / Q000009:adverse effects*; D005260:Female; D006801:Humans; D000068576:Interferon beta-1b; D016899:Interferon-beta / Q000009:adverse effects*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy*; D057049:Thrombotic Microangiopathies / Q000139:chemically induced*
chemical_list: D000276:Adjuvants, Immunologic; D000068576:Interferon beta-1b; D016899:Interferon-beta