title: Burning off DNA methylation: new evidence for oxygen-dependent DNA demethylation.
abstract: Where do you stop? Three recent publications have described how the oxidation of 5-methylcytosine by Tet dioxygenases does not stop at the 5-hydroxymethylcytosine (5hmC) state, rather further oxidation of 5hmC is involved in DNA demethylation. The nature of the enzymes involved in this process shed light on the dynamics of epigenetic signaling and its evolutionary origin.
authors: Biochemistry Laboratory, School of Engineering and Science, Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany.
authors: Tomasz P
authors: TP
authors: Jurkowski
authors: Albert
authors: A
authors: Jeltsch
mesh_terms: D044503:5-Methylcytosine / Q000378:metabolism; D004247:DNA / Q000378:metabolism*; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics / Q000378:metabolism; D019175:DNA Methylation; D049308:Dioxygenases / Q000235:genetics / Q000378:metabolism; D044127:Epigenesis, Genetic; D006801:Humans; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*
chemical_list: D044503:5-Methylcytosine; D004247:DNA; D049308:Dioxygenases; D004248:DNA (Cytosine-5-)-Methyltransferases; D010100:Oxygen