title: A spicamycin derivative (KRN5500) provides neuropathic pain relief in patients with advanced cancer: a placebo-controlled, proof-of-concept trial.
abstract: BACKGROUND
  Neuropathic pain in patients with cancer can be difficult to treat effectively.
  
  
  OBJECTIVE
  The purpose of the study was to determine safety and efficacy of KRN5500, a novel, spicamycin-derived, nonopioid analgesic agent, in patients with advanced cancer and neuropathic pain of any etiology.
  
  
  METHODS
  The study was a Phase 2a, multicenter, double-blind, placebo-controlled, dose escalation clinical trial. Patients with refractory neuropathic pain and advanced cancer were randomly assigned 2:1 to receive a maximum of eight single escalating doses of KRN5500 or placebo, ranging from 0.6 to 2.2 mg/m(2). The primary objective was safety and tolerability. The secondary objective was efficacy, measured by change in average pain intensity on a 0-10 numeric rating scale administered one week after the patient's final dose.
  
  
  RESULTS
  Nineteen patients received treatment (KRN5500 n=12; placebo n=7). The most frequently reported adverse events were gastrointestinal symptoms, which were more frequent and severe with KRN5500 than placebo; two (17%) KRN5500 patients discontinued the study because of nausea and vomiting. At study endpoint, KRN5500 exhibited a significant median decrease in pain intensity from baseline of 24% compared with 0% for placebo (P=0.03). The median for largest weekly reduction in target pain intensity was 29.5% for KRN5500 and 0% for placebo patients (P=0.02).
  
  
  CONCLUSIONS
  This proof-of-concept study for KRN5500 in patients with advanced cancer and any type of neuropathic pain found gastrointestinal adverse events to be the predominant safety concern. The results also provided the first indication of clinical and statistical efficacy in reducing pain intensity.
authors: Pain Medicine and Palliative Care Program, The Huntsman Cancer Institute, Salt Lake City, UT, USA.
authors: Sharon M
authors: SM
authors: Weinstein
authors: Amy P
authors: AP
authors: Abernethy
authors: Susan E
authors: SE
authors: Spruill
authors: Isadore M
authors: IM
authors: Pike
authors: Andrea
authors: A
authors: True Kelly
authors: Linda G
authors: LG
authors: Jett
mesh_terms: D000328:Adult; D000700:Analgesics / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D009437:Neuralgia / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control*; D010147:Pain Measurement / Q000187:drug effects*; D010865:Pilot Projects; D015990:Placebo Effect; D011684:Purine Nucleosides / Q000008:administration & dosage / Q000009:adverse effects; D015572:Spiramycin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013727:Terminal Care / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; D011684:Purine Nucleosides; D015572:Spiramycin; C092296:KRN 5500