title: Nanoparticle encapsulated silver carbene complexes and their antimicrobial and anticancer properties: a perspective.
abstract: This perspective discusses the uses of silver for both antimicrobial and anticancer applications. It focuses on the synthesis of silver N-heterocyclic carbene complexes (SCCs) and their in vitro efficacy against a broad spectrum of bacteria, as well as their antitumor properties. Finally, different polymeric nanoparticles are discussed as delivery vehicles for the encapsulation of SCCs and other therapeutic agents for use in vivo.
authors: Center for Silver Therapeutics Research, Department of Chemistry, University of Akron, Akron, OH 44325, USA. youngs@uakron.edu
authors: Wiley J
authors: WJ
authors: Youngs
authors: Amanda R
authors: AR
authors: Knapp
authors: Patrick O
authors: PO
authors: Wagers
authors: Claire A
authors: CA
authors: Tessier
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D012834:Silver / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D004337:Drug Carriers; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C030011:carbene; D012834:Silver; D008697:Methane