title: Experimental cardiac hypertrophy induced by oral administration of mineralocorticoid and saline in rats.
abstract: We suggest a new, easily applicable way of myocardial hypertrophy induction in rats. Forty randomized age-matched male Wistar rats were divided into 2 groups of 20 each: a control group and an orally administered fludrocortisone/salt group. Myocardial hypertrophy was estimated by measuring body weight, heart-weight-to-body-weight ratio and ventricular free wall thickness. Moderate myocardial hypertrophy without heart failure was established in fludrocortisone/salt group in 4 weeks. Our method is effective and low cost, and it provides a model of hypertrophic heart.
authors: Department of Cardiovascular and Thoracic Surgery, School of Medicine, University of Thessaly, Larissa, Greece. voucharas@gmail.com
authors: Christos
authors: C
authors: Voucharas
authors: Georgios
authors: G
authors: Tagarakis
authors: Antigoni
authors: A
authors: Lazou
authors: Filippos
authors: F
authors: Triposkiadis
authors: Nikolaos
authors: N
authors: Tsilimingas
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000633:toxicity; D006332:Cardiomegaly / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005438:Fludrocortisone / Q000008:administration & dosage / Q000633:toxicity*; D006352:Heart Ventricles / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012965:Sodium Chloride / Q000008:administration & dosage / Q000633:toxicity*; D020257:Ventricular Remodeling / Q000187:drug effects*
chemical_list: D000893:Anti-Inflammatory Agents; D012965:Sodium Chloride; D005438:Fludrocortisone