title: Control of cytoplasmic mRNA localization.
abstract: mRNA localization is a mechanism used by various organisms to control the spatial and temporal production of proteins. This process is a highly regulated event that requires multiple cis- and trans-acting elements that mediate the accurate localization of target mRNAs. The intrinsic nature of localization elements, together with their interaction with different RNA-binding proteins, establishes control mechanisms that can oversee the transcript from its birth in the nucleus to its specific final destination. In this review, we aim to summarize the different mechanisms of mRNA localization, with a particular focus on the various control mechanisms that affect the localization of mRNAs in the cytoplasm.
authors: Department of Biochemistry, Université de Montréal, 2900 Edouard-Montpetit, Montréal, Qc, Canada.
authors: Karen
authors: K
authors: Shahbabian
authors: Pascal
authors: P
authors: Chartrand
mesh_terms: D021581:Active Transport, Cell Nucleus; D000818:Animals; D003593:Cytoplasm / Q000378:metabolism*; D006801:Humans; D012326:RNA Splicing; D012333:RNA, Messenger / Q000032:analysis* / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D012333:RNA, Messenger; D016601:RNA-Binding Proteins