title: Do MDL-1⁺ cells play a broad role in acute inflammation?
abstract: Dengue virus (DV) reacts with myeloid DAP12-associating lectin-1 (MDL-1) on immature polymorphonuclear leukocytes. Interaction of DV with MDL-1+ cells triggers systemic inflammatory response syndrome (SIRS) and dengue shock syndrome (DSS), with subsequent multi-organ failure. In this issue of the JCI, Cheung et al. find that sterile acute liver injury in mice is associated with the accumulation of MDL-1+ cells and that triggering of these cells by DV or an MDL-1-specific agonist antibody leads to SIRS, shock, and death. These findings may have broad mechanistic and therapeutic implications for the development of SIRS, sepsis, and shock in humans exposed to a wide array of infectious and non-infectious conditions.
authors: University of Michigan Medical School, Department of Pathology, Ann Arbor, Michigan, USA. pward@umich.edu
authors: Peter A
authors: PA
authors: Ward
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D037181:Lectins, C-Type / Q000276:immunology*; D022423:Myeloid Cells / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000276:immunology*; D012769:Shock / Q000209:etiology* / Q000276:immunology*
chemical_list: C509772:Clec5a protein, mouse; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface