title: Analysis of association between common SNPs in ErbB4 and bipolar affective disorder, major depressive disorder and schizophrenia in the Han Chinese population.
abstract: Neuregulin-1 (NRG1) is associated with schizophrenia. As one of the receptors of NRG1, v-erb-a erythroblastic leukemia viral oncogene homolog 4 (ErbB4) has also been reported to be associated with schizophrenia. Since there can be shared genetic variants among bipolar affective disorder, major depressive disorder and schizophrenia, we tested the association between ErbB4 and these three major psychiatric disorders in the Han Chinese population. Five single nucleotide polymorphisms (SNPs) were selected based on previous positive reports and linkage disequilibrium information of the HapMap Han Chinese individuals from Beijing (CHB)+individuals from Tokyo, Japan (JPT) population. These SNPs were genotyped in 1140 bipolar affective disorder (BPAD) patients, 1140 schizophrenia (SCZ) patients, 1139 major depressive disorder (MDD) patients and 1140 normal controls. Two SNPs (rs707284 and rs839523) showed nominal significance in the BPAD patients but this was eliminated after permutation. No significant association between ErbB4 and the two other psychiatric disorders was observed, nor did haplotype analysis reveal any positive signal.
authors: Bio-X Center and Affiliated Changning Mental Health Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, PR China.
authors: Peng
authors: P
authors: Chen
authors: Jianhua
authors: J
authors: Chen
authors: Ke
authors: K
authors: Huang
authors: Weidong
authors: W
authors: Ji
authors: Ti
authors: T
authors: Wang
authors: Tao
authors: T
authors: Li
authors: Yang
authors: Y
authors: Wang
authors: Hankun
authors: H
authors: Wang
authors: Lin
authors: L
authors: He
authors: Guoyin
authors: G
authors: Feng
authors: Yongyong
authors: Y
authors: Shi
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D001714:Bipolar Disorder / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies / Q000379:methods; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D066247:Receptor, ErbB-4; D012559:Schizophrenia / Q000175:diagnosis* / Q000208:ethnology / Q000235:genetics; D055815:Young Adult
chemical_list: C587689:ERBB4 protein, human; D066246:ErbB Receptors; D066247:Receptor, ErbB-4