title: Selective catalytic hydrogenation of nitro groups in the presence of activated heteroaryl halides.
abstract: Chemoselective reduction of nitro groups in the presence of activated heteroaryl halides was achieved via catalytic hydrogenation with a commercially available sulfided platinum catalyst. The optimized conditions employ low temperature, pressure, and catalyst loading (<0.1 mol % Pt) to afford heteroaromatic amines with minimal hydrodehalogenation byproducts.
authors: Chemical Process Research and Development, Amgen Inc., Thousand Oaks, California 91320, USA. anniek@amgen.com
authors: Annie J
authors: AJ
authors: Kasparian
authors: Cecile
authors: C
authors: Savarin
authors: Alan M
authors: AM
authors: Allgeier
authors: Shawn D
authors: SD
authors: Walker
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D006865:Hydrogenation; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000588:Amines; D006846:Hydrocarbons, Halogenated