title: Evolution of the epidemiology of pneumococcal disease among Utah children through the vaccine era.
abstract: From 1996 to 2009, we analyzed changes in pneumococcal disease (PD) in Utah children aged <18 years using International Classification of Diseases, ninth revision coded hospital discharges. We observed a sustained decrease in the incidence of PD among children <5 years in 2001-2004 (-36%) and 2005-2009 (-34%) compared with 1996-2000 (pre-7-valent pneumococcal conjugate vaccine). Decreases were primarily in bacteremia, uncomplicated pneumonia, and meningitis. In contrast, significant increases in complicated pneumonia/empyema were noted in children <5 years (+95% and +85%) and 5 to 17 years (+2% and +70%). Despite decreases in PD among Utah children, complicated pneumonia/empyema has increased during the 7-valent pneumococcal conjugate vaccine era.
authors: Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA. krow.ampofo@hsc.utah.edu
authors: Krow
authors: K
authors: Ampofo
authors: Andrew T
authors: AT
authors: Pavia
authors: Chris R
authors: CR
authors: Stockmann
authors: Anne J
authors: AJ
authors: Blaschke
authors: Hsin Yi Cindy
authors: HY
authors: Weng
authors: Kent E
authors: KE
authors: Korgenski
authors: Judy
authors: J
authors: Daly
authors: Carrie L
authors: CL
authors: Byington
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D015994:Incidence; D007223:Infant; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage*; D013296:Streptococcus pneumoniae / Q000302:isolation & purification*; D014589:Utah / Q000453:epidemiology
chemical_list: D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022242:Pneumococcal Vaccines