title: Association of RELN promoter SNPs with schizophrenia in the Chinese population.
abstract: Previous research on gene expression analysis and association tests have suggested that RELN is a risk gene for schizophrenia in world populations. Based on the reported down-regulation of RELN in schizophrenia patients compared with normal subjects, we speculated that variants in the RELN promoter region may confer risk for schizophrenia. In this study, we investigated the associations of three SNPs in the promoter region of RELN with schizophrenia in a case-control sample from southwestern China (940 cases and 1 369 controls). The results suggested that none of the SNPs showed significant associations in our sample, indicating the risk variants for schizophrenia in RELN may not be located in the promoter region. We also performed meta-analysis by combining our data with previously reported data on the Chinese population with a total sample size of 2 843 individuals, and the result remained non-significant. Collectively, our results suggested variants in the RELN promoter may not harbor risk SNPs associated with schizophrenia in the Chinese population.
authors: The First Affiliated Hospital of Kunming Medical College, Kunming 650032, China.
authors: Lü-Hua
authors: LH
authors: Chang
authors: Ming
authors: M
authors: Li
authors: Xiong-Jian
authors: XJ
authors: Luo
authors: Xing-Yan
authors: XY
authors: Liu
authors: Li-De
authors: LD
authors: Yin
authors: Shun-Ying
authors: SY
authors: Yang
authors: Hong-Bo
authors: HB
authors: Diao
authors: Bing
authors: B
authors: Su
authors: Xing-Fu
authors: XF
authors: Pu
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics*; D002681:China / Q000208:ethnology; D016326:Extracellular Matrix Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D000091042:Reelin Protein; D012559:Schizophrenia / Q000201:enzymology / Q000235:genetics*; D012697:Serine Endopeptidases / Q000235:genetics*
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D009419:Nerve Tissue Proteins; D000091042:Reelin Protein; C000717127:RELN protein, human; D012697:Serine Endopeptidases