title: Dual buffer gases for ion manipulation in a miniature ion trap mass spectrometer with a discontinuous atmospheric pressure interface.
abstract: The discontinuous atmospheric pressure interface (DAPI) has been developed to allow a direct transfer of ions from atmosphere into an ion trap mass spectrometer with minimum pumping capability. Air is introduced into the trap with ions and used as a buffer gas for the ion trap operation. In this study, a method of introducing helium as a second buffer gas was developed for a miniature mass spectrometer using a dual DAPI configuration. The buffer gas effects on the performance of a linear ion trap (LIT) with hyperbolic electrodes were characterized for ion isolation, fragmentation and a mass-selective instability scan. Significant improvement was obtained with helium for resolutions of mass analysis and ion isolation, while moderate advantage was gained with air for collision-induced dissociation. The buffer gas can be switched between air and helium for different steps within a single scan, which allows further optimization of the instrument performance for tandem mass spectrometry.
authors: Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
authors: Tsung-Chi
authors: TC
authors: Chen
authors: Wei
authors: W
authors: Xu
authors: Zheng
authors: Z
authors: Ouyang
mesh_terms: D001920:Bradykinin / Q000737:chemistry; D002082:Butylamines / Q000737:chemistry; D003042:Cocaine / Q000737:chemistry; D003508:Cycloheptanes / Q000737:chemistry; D004867:Equipment Design; D005740:Gases / Q000737:chemistry*; D013058:Mass Spectrometry / Q000295:instrumentation* / Q000379:methods*; D008904:Miniaturization / Q000295:instrumentation*; D053719:Tandem Mass Spectrometry
chemical_list: D002082:Butylamines; D003508:Cycloheptanes; D005740:Gases; C034591:cycloheptylamine; D003042:Cocaine; C032462:n-butylamine; D001920:Bradykinin