title: Anti-oxidative, anti-inflammatory and whitening effects of phenolic compounds from Bambusae Caulis in Liquamen.
abstract: Bambusae Caulis in Liquamen (BCL) is the distilled product of the condensation from the burning of Phyllostachys nigra var. henosis (Gramineae). The activity-guided isolation of BCL yielded four phenolic compounds: 2,6-dimethoxyphenol (1), 1,2-dihydroxybenzene (2), 1,3-dihydroxybenzene (3) and 1,2-dibenzenecarboxylic acid (4). We evaluated the anti-oxidative, anti-inflammatory and whitening effects of these compounds, via assays, of 1,1-diphenyl-2-picrylhydazyl (DPPH) radical scavenging activity and inhibition of nitric oxide (NO) production in lipopolysaccharide-stimulated RAW 264.7 macrophage cells as well as inhibition of tyrosinase activity and melanin production in B16F10 melanoma cells. The results showed that 2 and 3 exhibited significant DPPH radical scavenging activity as well as inhibitory effects on NO production, tyrosinase activity and melanin production. These results suggested that BCL and compounds 2 and 3 can be developed as anti-oxidative, anti-inflammatory and whitening ingredients.
authors: College of Pharmacy, Chung-Ang University, Seoul 156-756, South Korea.
authors: Kwan Hee
authors: KH
authors: Park
authors: Min Won
authors: MW
authors: Lee
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry; D002460:Cell Line; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D008543:Melanins / Q000378:metabolism; D014442:Monophenol Monooxygenase / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology*; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D006109:Poaceae / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D008070:Lipopolysaccharides; D008543:Melanins; D010636:Phenols; D010851:Picrates; D010936:Plant Extracts; D009569:Nitric Oxide; C004931:1,1-diphenyl-2-picrylhydrazyl; D014442:Monophenol Monooxygenase