title: Transdermal estrogen therapy effects on fibrinogen levels in women with a past history of venous thromboembolism: a pilot study.
abstract: OBJECTIVE
  To evaluate thromboelastographic parameters and fibrinogen levels in women treated with transdermal 17beta estradiol.
  
  
  METHODS
  29 menopausal women with a history of venous thromboembolic disease were included. Nine patients composed the treatment (HT) group and 20 the control group. Coagulation was assessed by thromboelastography in samples of whole blood and platelet-poor plasma (PPP). The following thromboelastographic variables were measured: time for initial coagulation (R), blood clotting speed (K and the alpha angle), clot tensile strength (MA and G), global index of coagulation (CI) and fibrinolysis (LY30) and fibrinogen levels.
  
  
  RESULTS
  There were no differences in the other parameters comparing both groups. Fibrinogen levels showed a 13.77 +/- 19.94% reduction in the HT group and a 5.51 +/- 8.09% increase in the control group after 6 months.
  
  
  CONCLUSIONS
  Our data suggested that transdermal estrogen may not increase blood coagulability, but that it reduces fibrinogen levels in HT women.
authors: Department of Obstetrics and Gynecology, São Paulo University, São Paulo, Brazil.
authors: P F R
authors: PF
authors: Margarido
authors: V R
authors: VR
authors: Bagnoli
authors: A
authors: A
authors: Maggio da Fonseca
authors: G A R
authors: GA
authors: Maciel
authors: J M
authors: JM
authors: Soares
authors: E A
authors: EA
authors: D'Amico
authors: E C
authors: EC
authors: Baracat
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000704:Analysis of Variance; D004958:Estradiol / Q000008:administration & dosage*; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000008:administration & dosage*; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D006801:Humans; D008875:Middle Aged; D010865:Pilot Projects; D013916:Thrombelastography; D054556:Venous Thromboembolism / Q000097:blood*
chemical_list: D004967:Estrogens; D004958:Estradiol; D005340:Fibrinogen