title: Diabetic ketoacidosis with L-asparaginase therapy.
abstract: Diabetic ketoacidosisis as a complication of L-asparaginase therapy in children with acute leukemia is rare. Hyperglycemia may occur in about 10% of cases receiving Lasp, which may present as mild glucose intolerance to severe hyperglycemia. We report two children with acute lymphoblastic leukemia who developed diabetic ketoacidosis after treatment with L-asparaginase.
authors: Department of Pediatric Medicine, IPGMER and SSKM Hospital, Kolkata, India. rkm1971@indiatimes.com
authors: Rakesh
authors: R
authors: Mondal
authors: Madhumita
authors: M
authors: Nandi
authors: Astha
authors: A
authors: Tiwari
authors: Swati
authors: S
authors: Chakravorti
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects; D001215:Asparaginase / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D016883:Diabetic Ketoacidosis / Q000139:chemically induced* / Q000175:diagnosis; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D001215:Asparaginase