title: PARG: a macrodomain in disguise.
abstract: Our understanding of poly-ADP-ribosylation as a posttranslational modification was limited by the lack of structural information on poly-ADP-ribose (PAR) hydrolysing enzymes. A recent study in Nature (Slade et al., 2011) reports the structure of PAR glycohydrolase (PARG), revealing unexpected similarity to the ubiquitous ADP-ribose-binding macrodomains.
authors: Genome Biology Unit and Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
authors: Markus
authors: M
authors: Hassler
authors: Gytis
authors: G
authors: Jankevicius
authors: Andreas G
authors: AG
authors: Ladurner