title: Association of the FTO rs9939609 polymorphism with obesity in Roma/Gypsy population.
abstract: The rs9939609 SNP located in the first intron of the fat mass and obesity associated gene (FTO) has been found to be associated with common obesity mainly in populations of European descent. The Roma/Gypsy population as an ethnic minority of Asian Indian origin is well known for its adverse health status with a high prevalence of obesity. The main aim of this study was to examine the contribution of the rs9939609 FTO polymorphism to the high prevalence of obesity in the Roma/Gypsy population. Following a number of anthropometric measurements, the FTO rs9939609 polymorphism was genotyped in 312 Roma/Gypsy individuals. We observed significant differences in body mass index (BMI), waist circumference, and waist-to-hip ratio between different genotypes (P = 0.003, P = 0.012, and P = 0.03, respectively). The waist circumference in the subjects with AA genotype was about 7.1 cm larger than in those with TT genotypes (P = 0.005). However, the strongest association of minor allele A of the rs9939609 FTO polymorphism was found with BMI (odds ratio, 1.55; 95% confidence interval, 1.129-2.128; P = 0.007), even after adjusting for age, sex, and smoking status. This study provides the first report of allele and genotype frequencies for the rs9939609 polymorphism and also the first evidence of the association of the FTO variant with obesity in the Roma/Gypsy population.
authors: Excellence Centre of Animal and Human Ecology, University of Presov, Slovakia. murna@centrum.sk
authors: Soňa
authors: S
authors: Mačeková
authors: Ivan
authors: I
authors: Bernasovský
authors: Dana
authors: D
authors: Gabriková
authors: Alexandra
authors: A
authors: Bôžiková
authors: Jarmila
authors: J
authors: Bernasovská
authors: Iveta
authors: I
authors: Boroňová
authors: Regina
authors: R
authors: Behulová
authors: Petra
authors: P
authors: Svíčková
authors: Eva
authors: E
authors: Petrejčíková
authors: Miroslav
authors: M
authors: Soták
authors: Adriana
authors: A
authors: Sovičová
authors: Jana
authors: J
authors: Carnogurská
mesh_terms: D000328:Adult; D000368:Aged; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D015992:Body Mass Index; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D009765:Obesity / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*; D006178:Romani People / Q000235:genetics* / Q000706:statistics & numerical data; D018154:Slovakia / Q000453:epidemiology; D018709:Statistics, Nonparametric; D055105:Waist Circumference; D049629:Waist-Hip Ratio
chemical_list: D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human