title: Body mass index, cognition, disability, APOE genotype, and mortality: the "Treviso Longeva" Study.
abstract: OBJECTIVE
  The concurrent contributions of dynamic, interrelated late-life parameters, such as body mass index (BMI), cognition, and physical functioning on mortality in the elderly are unclear, as is the influence of APOE genotype. We explored these measures in relation to 7-year mortality in long-lived Italian elderly.
  
  
  METHODS
  A representative, age-stratified, population sample.
  
  
  METHODS
  The Treviso Longeva (TRELONG) Study, in Treviso, Italy.
  
  
  METHODS
  Three hundred eleven men and 357 women, aged 70 years and older (mean age 84 ± 8 years).
  
  
  METHODS
  Seven-year mortality, BMI, Mini-Mental State Examination (MMSE) score, Activities of Daily Living (ADL), APOE genotype, and a variety of clinical and survey data.
  
  
  RESULTS
  In separate age- and sex-adjusted analyses, BMI <18.5 kg/m(2), MMSE ≤24, and ADL <6, were associated with greater 7-year mortality among adults aged 70 years and older. In a multivariate model including all factors, MMSE ≤24, and ADL <6 were associated with greater mortality; BMI ≥30 kg/m(2) was protective. There were no interactions between BMI, MMSE, or ADL. When excluding those dying within 3 years of baseline, only an MMSE ≤24 was related to mortality. APOEε4 was not related to mortality.
  
  
  CONCLUSIONS
  Higher MMSE score, higher ADL score, and higher BMI, independent of age, sex, and other factors, are markers for longer life among northern Italian adults aged 70 years or older. Global cognition, BMI, and physical functioning, assessed by short, simple tests are profound indicators of death within less than a decade.
authors: Institute for Neuroscience and Physiology, NeuroPsychiatric Epidemiology Unit, University of Gothenburg,Wallinsgatan 6, 431 41 Gothenburg, Sweden. deborah.gustafson@neuro.gu.se
authors: Deborah R
authors: DR
authors: Gustafson
authors: Stephano
authors: S
authors: Mazzuco
authors: Fausta
authors: F
authors: Ongaro
authors: Piero
authors: P
authors: Antuono
authors: Gianluigi
authors: G
authors: Forloni
authors: Diego
authors: D
authors: Albani
authors: Gian Battista
authors: GB
authors: Gajo
authors: Elisabetta
authors: E
authors: Durante
authors: Livio
authors: L
authors: Caberlotto
authors: Andrea
authors: A
authors: Zanardo
authors: Marinella
authors: M
authors: Siculi
authors: Maurizio
authors: M
authors: Gallucci
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology*; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics* / Q000523:psychology*; D001057:Apolipoproteins E / Q000235:genetics*; D015992:Body Mass Index; D003071:Cognition / Q000502:physiology*; D004185:Disability Evaluation; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D009026:Mortality; D009483:Neuropsychological Tests / Q000706:statistics & numerical data
chemical_list: D001057:Apolipoproteins E