title: Biochemical rationale and experimental data on the antiaging properties of CoQ(10)  at skin level.
abstract: Coenzyme Q(10)  (CoQ(10) ) is a key component of the mitochondrial respiratory chain and, therefore, is essential for the bioenergetics of oxidative phosphorylation. It is also endowed with antioxidant properties, and recent studies pointed out its capability of affecting the expression of different genes. In this review, we analyze the data on the mechanisms by which CoQ(10)  interacts with skin aging processes. The effect of CoQ(10)  in preserving mitochondrial function cooperates in maintaining a proper energy level, which serves to prevent the aging skin from switching to anaerobic energy production mechanisms. Furthermore, the antioxidant capacity of CoQ(10)  contributes to a positive effect against UV-mediated oxidative stress. Some of these effects have been assessed also in vivo, by the sensitive technique of ultraweak photoemission. Finally, CoQ(10)  has been shown to influence, through a gene induction mechanism, the synthesis of some key proteins of the skin and to decrease the expression of some metalloproteinase such as collagenase. These mechanisms may also contribute to preserve collagen content of the skin.
authors: Beiersdorf AG, Research and Development, Hamburg, Germany.
authors: Thomas
authors: T
authors: Blatt
authors: Gian Paolo
authors: GP
authors: Littarru
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000378:metabolism; D004734:Energy Metabolism; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000235:genetics; D016032:Randomized Controlled Trials as Topic; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D015595:Skin Aging / Q000187:drug effects*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000172:deficiency / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D008074:Lipoproteins; D014451:Ubiquinone; C024989:coenzyme Q10