title: [Diterpene constituents of Tripterygium willfordii (II)].
abstract: In order to study the constituents and pharmacology of Tripterygium plants (Tripterygium willfordii Hook.f), a variety of chromatography methods were used. Four compounds were isolated from Tripterygium plant and their structures were elucidated by UV, IR, MS, HR-MS, 1H NMR, 13C NMR and 2D-NMR techniques. The isolated compounds were named as triptonide (1), neo-triptetraolide (2), 2alpha-hydroxytriptonide (3), and 15-hydroxytriptonide (4), separately. Compounds 3, 4 belong to new diterpenoids, which can inhibit the growth of K562 cells (leukemia cells) and HL60 cells (acute myeloid leukemia cells).
authors: Fujian Institute of Medical Sciences, Fuzhou 350001, China. linsui_syy@sina.com.cn
authors: Sui
authors: S
authors: Lin
authors: Hui-Qing
authors: HQ
authors: Que
authors: Hua-Yi
authors: HY
authors: Peng
authors: Li-Ping
authors: LP
authors: Qian
authors: Shun-Min
authors: SM
authors: Guo
authors: Yuan-Chao
authors: YC
authors: Li
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D020014:K562 Cells; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D029757:Tripterygium / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification
chemical_list: C578906:15-hydroxytriptonide; C578905:2alpha-hydroxytriptonide; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D014315:Triterpenes; C084079:triptonide