title: NMR and MRI of blood-dissolved hyperpolarized Xe-129 in different hollow-fiber membranes.
abstract: Magnetic resonance of hyperpolarized (129)Xe has found a wide field of applications in the analysis of biologically relevant fluids. Recently, it has been shown that the dissolution of hyperpolarized gas into the fluid via hollow-fiber membranes leads to bubble-free (129)Xe augmentation, and thus to an enhanced signal. In addition, hollow-fiber membranes permit a continuous operation mode. Herein, a quantitative magnetic resonance imaging and spectroscopy analysis of a customized hollow-fiber membrane module is presented. Different commercial hollow-fiber membrane types are compared with regard to their (129)Xe dissolution efficiency into porcine blood, its constituents, and other fluids. The presented study gives new insight into the suitability of these hollow-fiber membrane types for hyperpolarized gas dissolution setups.
authors: Institute for Technical and Macromolecular Chemistry, RWTH Aachen University, Worringer Weg 1, 52074 Aachen, Germany. amor@itmc.rwth-aachen.de
authors: Nadia
authors: N
authors: Amor
authors: Kathrin
authors: K
authors: Hamilton
authors: Markus
authors: M
authors: Küppers
authors: Ulrich
authors: U
authors: Steinseifer
authors: Stephan
authors: S
authors: Appelt
authors: Bernhard
authors: B
authors: Blümich
authors: Thomas
authors: T
authors: Schmitz-Rode
mesh_terms: D000818:Animals; D004867:Equipment Design; D006454:Hemoglobins / Q000032:analysis; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D008567:Membranes, Artificial; D010100:Oxygen / Q000097:blood*; D011090:Polyenes / Q000737:chemistry*; D016062:Porosity; D012995:Solubility; D012996:Solutions; D013499:Surface Properties; D013552:Swine; D014979:Xenon Isotopes / Q000097:blood*
chemical_list: D006454:Hemoglobins; D008567:Membranes, Artificial; D011090:Polyenes; D012996:Solutions; D014979:Xenon Isotopes; C035051:PL 732; D010100:Oxygen