title: The emergence of pan-resistant Gram-negative pathogens merits a rapid global political response.
abstract: Recent media coverage of New Delhi metallo-β-lactamase (NDM-1) put antibiotic resistance back on the political map if only for the wrong reasons, mainly the reaction to the naming of NDM-1 and the incorrect assumption that medical tourism was being deliberately targeted. However, work on NDM-1 has most certainly highlighted the rapid dissemination of new antibiotic resistance mechanisms via economic globalization. The example of NDM-1 has also magnified the desperate need for a publicly funded global antibiotic surveillance system rather than just national or regional systems. Furthermore, there is a pressing need to establish a global task force to enforce international transparency and accountability on antibiotic stewardship and the implementation of measures to curb antibiotic resistance. An international antibiotic stewardship index should be established that is related to each country's gross domestic product (GDP) and assesses how much of their GDP is committed to publically funded health initiatives aimed at controlling antibiotic resistance.
authors: Section of Medical Microbiology, 6th Floor Main Building, IIB, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. t.r.walsh@uq.edu.au
authors: Timothy R
authors: TR
authors: Walsh
authors: Mark A
authors: MA
authors: Toleman
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D011307:Drug Prescriptions / Q000592:standards*; D024901:Drug Resistance, Multiple, Bacterial; D004363:Drug Utilization / Q000592:standards*; D014943:Global Health; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000201:enzymology / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000382:microbiology*; D006291:Health Policy; D006801:Humans; D007391:International Cooperation; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1