title: Phytochemical screening, antibacterial activity and in vitro interactions between Costus cf. arabicus L. with UV-A and aminoglycosides.
abstract: In this study, the methanol extracts of of Costus cf. arabicus L. were evaluated for antibacterial activity against multiresistant strains of Escherichia coli and Staphylococcus aureus. The antibacterial and modulatory activity of the extracts was assayed by microdilution. The light-enhanced antibacterial activity was assayed by light regimen. The growth of the bacteria tested was not inhibited by the extracts. The minimum inhibitory concentration (MIC) values ranged from 512 to ≥1024 µg·m L(-1). However, the antibiotic activity of the aminoglycosides was synergistically enhanced when these extracts were associated in sub-inhibitory concentrations with the antibiotics. Both extracts showed activity against at two standard bacterial strains. Because of this, we suggest that the ethanol extracts of the stems and leaves of Costus cf. arabicus L. show potential antibacterial, light-induced and synergistic antibiotic activity. With such results, these extracts are proven to be a promising source of antibacterial and modulatory agents.
authors: Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato (CE), Brazil.
authors: Francisco A B
authors: FA
authors: Cunha
authors: Edinardo F F
authors: EF
authors: Matias
authors: Samuel V
authors: SV
authors: Brito
authors: Felipe S
authors: FS
authors: Ferreira
authors: João Marcelo A
authors: JM
authors: Braga
authors: José G M
authors: JG
authors: Costa
authors: Henrique D M
authors: HD
authors: Coutinho
mesh_terms: D000617:Aminoglycosides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D029770:Costus / Q000737:chemistry*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects; D000431:Ethanol / Q000737:chemistry; D000432:Methanol / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects; D014466:Ultraviolet Rays
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D000431:Ethanol; D000432:Methanol