title: [Levels of serum acylation-stimulating protein and C3 in children with primary nephrotic syndrome].
abstract: OBJECTIVE
  To study serum acylation-stimulating protein (ASP) and complement 3 (C3) levels and their relationship with blood lipids in children with primary nephrotic syndrome (PNS).
  
  
  METHODS
  Blood samples were obtained from 35 PNS children with proteinuria, 25 children with PNS at remission and 35 body mass index-matched healthy children (control group). Fasting serum ASP, C3, albumin and blood lipids were measured.
  
  
  RESULTS
  The serum ASP levels in the proteinuria group (101 ± 22 nmol/L) were significantly higher than those in the remission group (32 ± 8 nmol/L) and the control group (33 ± 8 nmol/L) (P<0.01). Serum C3 levels were not significantly different among the three groups. The serum concentrations of total cholesterol, triglyceride, low density lipoprotein and apolipoprotein B increased, in contrast, serum albumin level decreased significantly in the proteinuria group when compared with the remission and the control groups. Serum ASP levels were positively correlated with serum C3 (r=0.661; P<0.05) and triglyceride levels (r=0.354; P<0.05), whereas serum C3 levels were not correlated with serum triglyceride levels (r=0.319, P>0.05).
  
  
  CONCLUSIONS
  The increased serum ASP level may be associated with a complemental mechanism against hyperlipidemia in children with PNS.
authors: Department of Pediatrics, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China. wjjsl2003@yahoo.com.cn
authors: Jian-Jun
authors: JJ
authors: Wang
authors: Yue
authors: Y
authors: Huang
authors: Chun
authors: C
authors: Wu
authors: Yu-Xia
authors: YX
authors: Xu
authors: Yu-Shu
authors: YS
authors: Wei
authors: Yao
authors: Y
authors: Zhao
mesh_terms: D002675:Child, Preschool; D003176:Complement C3 / Q000032:analysis*; D005260:Female; D006801:Humans; D007223:Infant; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008055:Lipids / Q000097:blood; D008297:Male; D009404:Nephrotic Syndrome / Q000097:blood*; D012709:Serum Albumin / Q000032:analysis
chemical_list: C038245:C3 protein, human; D003176:Complement C3; D036341:Intercellular Signaling Peptides and Proteins; D008055:Lipids; D012709:Serum Albumin