title: Partial status epilepticus after electroconvulsive therapy and medical treatment with bupropion.
abstract: Electroconvulsive therapy (ECT) is the most effective treatment for therapy-refractory depression. Usually, prior antidepressant medication will be continued during ECT. However, the seizure threshold may be influenced by psychotropic drugs. We report a patient who received right unilateral ECT under concomitant treatment with bupropion, a selective noradrenaline- and dopamine-reuptake inhibitor. After the fourth session, a focal status epilepticus occurred, which was pharmacoresistant for the duration of 12 days. We assume that the induction of a status may be facilitated by a lowering of the seizure threshold due to bupropion. An evaluation of drug therapy and control of EEG before and during ECT are recommended, especially when the drug treatment has an influence on the seizure threshold.
authors: R
authors: R
authors: Dersch
authors: S
authors: S
authors: Zwernemann
authors: U
authors: U
authors: Voderholzer
mesh_terms: D018759:Adrenergic Uptake Inhibitors / Q000009:adverse effects*; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects*; D016642:Bupropion / Q000009:adverse effects*; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000523:psychology / Q000628:therapy; D000068736:Duloxetine Hydrochloride; D004565:Electroconvulsive Therapy / Q000009:adverse effects*; D004569:Electroencephalography; D006801:Humans; D008297:Male; D012640:Seizures / Q000188:drug therapy; D013226:Status Epilepticus / Q000188:drug therapy / Q000209:etiology*; D013876:Thiophenes / Q000627:therapeutic use
chemical_list: D018759:Adrenergic Uptake Inhibitors; D000927:Anticonvulsants; D018687:Antidepressive Agents, Second-Generation; D013876:Thiophenes; D016642:Bupropion; D000068736:Duloxetine Hydrochloride