title: Novel palladium(II) complexes containing a sulfur ligand: structure and biological activity on HeLa cells.
abstract: Two novel palladium(II) complexes with a thiosalicylic acid (HSC(6)H(4)CO(2)H) ligand, with the formulas [Pd(TSA)(L)]·mH(2)O (TSA is thiosalicylic acid; in complex 1, L is 1,10-phenanthroline and m = 1; in complex 2, L is 2,2'-bipyridine and m = 2), have been synthesized and characterized. The coordination geometry of both palladium atoms is square planar; they are four-coordinated and each is coordinated in an N,N,O(-),S(-) mode. There is a sigmoid oxygen chain in complex 1, but an oxygen ring in complex 2. The competitive binding of the complexes to HeLa cell DNA (HL-DNA) has been investigated by fluorescence spectroscopy. The results show that the two complexes have the ability to bind with HL-DNA. Viscosity studies suggest that the complexes bind to DNA by intercalation. Gel electrophoresis assay demonstrated the ability of the complexes to cleave the HL-DNA. The two complexes exhibit cytotoxic specificity and a significant cancer cell inhibitory rate. The apoptosis tests indicated that the complexes have an apoptotic effect. Furthermore, complex 1 exhibits more biological activity than complex 2, which is mainly because the area of the aromatic ring of 1,10-phenanthroline is larger than that of 2,2'-bipyridine.
authors: Department of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, 110142, China. ejgao@yahoo.com.cn
authors: EnJun
authors: E
authors: Gao
authors: Feng
authors: F
authors: Guan
authors: XiaNan
authors: X
authors: Gao
authors: MingChang
authors: M
authors: Zhu
authors: Lei
authors: L
authors: Liu
authors: ChuanSheng
authors: C
authors: Wang
authors: WanZhong
authors: W
authors: Zhang
authors: YaGuang
authors: Y
authors: Sun
mesh_terms: D015082:2,2'-Dipyridyl / Q000737:chemistry; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D004247:DNA / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D007364:Intercalating Agents / Q000737:chemistry / Q000494:pharmacology; D008024:Ligands; D009369:Neoplasms / Q000188:drug therapy; D010165:Palladium / Q000737:chemistry* / Q000494:pharmacology*; D010618:Phenanthrolines / Q000737:chemistry / Q000494:pharmacology; D012459:Salicylates / Q000737:chemistry* / Q000494:pharmacology*; D013438:Sulfhydryl Compounds / Q000737:chemistry* / Q000494:pharmacology*; D013455:Sulfur / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D007364:Intercalating Agents; D008024:Ligands; D010618:Phenanthrolines; D012459:Salicylates; D013438:Sulfhydryl Compounds; D015082:2,2'-Dipyridyl; D010165:Palladium; D013455:Sulfur; D004247:DNA; C441201:thiosalicylic acid; C025205:1,10-phenanthroline