title: Development of gastro intestinal sustained release tablet formulation containing acryl-EZE and pH-dependent swelling HPMC K 15 M.
abstract: BACKGROUND
  The aim of this study was to evaluate physical properties and release from matrix tablets containing different ratios of HPMC 15 M and Acryl-EZE. A further aim is to assess their suitability for pH dependent controlled release.
  
  
  METHODS
  Matrix tablets containing HPMC 15 M and Acryl-EZE were manufactured using a fluidized bed. The release from this matrix using Sodium Diclofenac (SD) as model drug is studied in two dissolution media (0.1 N HCl or pH = 6.8 phosphate buffer solution); the release rate, mechanism, and pH dependence were characterized by fitting four kinetic models and by using a similarity factor analysis.
  
  
  RESULTS
  The obtained results revealed that the presence of Acryl-EZE in the matrix tablets is effective in protecting the dosage forms from release in acid environments such as gastric fluid. In pH = 6.8 phosphate buffer, the drug release rate and mechanism of release from all matrices is mainly controlled by HPMC 15 M. The model of Korsmeyer-Peppas was found to fit experimental dissolution results.
authors: University of Science and Technology, Houari Boumediene, Faculty of Mechanical and Process Engineering, Bab Ezzouar, Algiers, Algeria.
authors: Lynda
authors: L
authors: Lamoudi
authors: Jean Claude
authors: JC
authors: Chaumeil
authors: Kamel
authors: K
authors: Daoud
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D001682:Biological Availability; D001843:Bone Cements / Q000737:chemistry; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000737:chemistry; D004008:Diclofenac / Q000737:chemistry*; D005079:Excipients / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D008962:Models, Theoretical; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D012995:Solubility; D013607:Tablets / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001843:Bone Cements; D003692:Delayed-Action Preparations; D005079:Excipients; D013607:Tablets; D004008:Diclofenac; D002482:Cellulose; D019904:Polymethyl Methacrylate; C008079:hydroxypropylcellulose