title: Atherosclerotic disease of the abdominal aorta and its branches: prognostic implications in patients with heart failure.
abstract: Aortic atherosclerosis reduces compliance in the systemic circulation and increases peripheral resistance, afterload and left ventricular wall stress. In patients with heart failure, these changes can impair left ventricular systolic function and energy efficiency, which could reduce exercise capacity. Though the interaction and the impact of aortic atherosclerosis on left ventricular function have been investigated, its prognostic implications in patients with heart failure are unclear. We used cardiac magnetic resonance imaging and gadolinium-enhanced abdominal aortography to investigate the prevalence and prognostic impact of atherosclerotic disease of the abdominal aorta and its side branches in 355 patients with heart failure. Sclerotic abdominal aortic disease was defined as a luminal narrowing >50% of the aorta and its side branches or the presence of abdominal aortic aneurysm. Patients with disease of the aorta and its branches were older (P < 0.0001), had overall longer stay in hospital (P = 0.006) and had more admissions (P = 0.001) and worse prognosis (hazard ratio: 1.97, 95% confidence interval: 1.29-3.00, P = 0.002) than those without. In a multivariable model, increasing age and pulse pressure, diabetes mellitus and increasing left ventricular end-diastolic volume were associated with a worse prognosis, but sclerotic abdominal aortic disease was not independently related to outcome (hazard ratio: 1.06; 95% confidence interval: 0.64-1.74; P = 0.823). These data demonstrate that atherosclerosis of the abdominal aorta and its side branches is common and associated with increased morbidity in patients with chronic heart failure. How such disease should be managed remains uncertain, but its recognition and characterisation are the first steps in finding out.
authors: Department of Cardiology, Academic Unit, University of Hull, PO BOX HU16 5JQ, Kingston-upon-Hull, UK. cbourantas@gmail.com
authors: Christos V
authors: CV
authors: Bourantas
authors: Huan P
authors: HP
authors: Loh
authors: Nasser
authors: N
authors: Sherwi
authors: Ann C
authors: AC
authors: Tweddel
authors: Ramesh
authors: R
authors: de Silva
authors: Elena I
authors: EI
authors: Lukaschuk
authors: Antony
authors: A
authors: Nicholson
authors: Alan S
authors: AS
authors: Rigby
authors: Simon D
authors: SD
authors: Thackray
authors: Duncan F
authors: DF
authors: Ettles
authors: Nikolay P
authors: NP
authors: Nikitin
authors: Andrew L
authors: AL
authors: Clark
authors: John G F
authors: JG
authors: Cleland
mesh_terms: D000368:Aged; D001012:Aorta, Abdominal / Q000473:pathology; D001018:Aortic Diseases / Q000473:pathology / Q000503:physiopathology*; D050197:Atherosclerosis / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D006321:Heart / Q000503:physiopathology; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012078:Renal Artery Obstruction / Q000503:physiopathology*; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology*; D016277:Ventricular Function, Left / Q000502:physiology*