title: Liquid-based cytology in fine-needle aspiration biopsies of the thyroid gland.
abstract: OBJECTIVE
  Fine-needle aspiration biopsy is regarded as the most important diagnostic tool for thyroid lesions because of its simplicity, safety, and cost-effectiveness. However, its pivotal role in the correct characterization of the majority of nodules is impaired by the difficulties in discriminating benign from malignant follicular-patterned lesions.
  
  
  METHODS
  Liquid-based cytology (LBC) is a semiautomated device that has recently become widely available and has gained popularity as a method of collecting and processing both gynecologic and nongynecologic cytologic specimens. It achieves a diagnostic sensitivity as accurate as conventional preparations, especially for its excellent cell preservation and lack of background which decrease the amount of inadequate diagnoses.
  
  
  RESULTS
  In many cases the cytologic features are similar in both methods, but the colloid film and the lymphocytic component are more easily evaluated on direct smears whereas nuclear details and colloid globules are better evaluated in LBC slides. The material stored in the preservative solution could be effectively used for the application of immunocytochemical and molecular techniques.
  
  
  CONCLUSIONS
  LBC-processed biopsies represent a valid alternative to conventional cytology. The possibility of applying additional techniques enhances the efficacy of the cytologic diagnosis of thyroid lesions.
authors: Agostino Gemelli School of Medicine and Hospital, Università Cattolica del Sacro Cuore, Rome, Italy. guidofadda@rm.unicatt.it
authors: Guido
authors: G
authors: Fadda
authors: Esther Diana
authors: ED
authors: Rossi
mesh_terms: D044963:Biopsy, Fine-Needle; D003581:Cytodiagnosis; D003584:Cytological Techniques; D006801:Humans; D013961:Thyroid Gland / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000175:diagnosis*; D016606:Thyroid Nodule / Q000473:pathology*