title: Impact of disease on interferences in blood bioanalysis.
abstract: Most diseases will influence the blood biochemical homeostasis. Analysis of these biochemical modifications is used for diagnostic purposes and for follow-up of treated patients. Sometimes, however, these disease-induced blood matrix modifications interfere with bioanalytical assays. As a consequence erroneous high or low results can be reported. This article focuses on these particular problems by using examples from the literature and discussions about possible mechanisms that may explain the interferences.
authors: Stichting KCL, Department for Clinical Chemistry & Laboratory Medicine, Borniastraat 34, Leeuwarden, The Netherlands. a.wolthuis@kcl.znb.nl
authors: Albert
authors: A
authors: Wolthuis
mesh_terms: D001323:Autoantibodies / Q000097:blood; D001681:Biological Assay; D015415:Biomarkers / Q000097:blood; D001774:Blood Chemical Analysis; D002845:Chromatography / Q000379:methods; D016638:Critical Illness; D004194:Disease; D006207:Half-Life; D006801:Humans; D007154:Immune System Diseases / Q000097:blood*; D007118:Immunoassay; D008107:Liver Diseases / Q000097:blood; D013058:Mass Spectrometry / Q000379:methods; D009101:Multiple Myeloma / Q000097:blood; D008258:Waldenstrom Macroglobulinemia / Q000097:blood
chemical_list: D001323:Autoantibodies; D015415:Biomarkers