title: Targeting heat shock response pathways to treat pancreatic cancer.
abstract: Pancreatic cancer belongs to the group of extremely aggressive human cancers; conventional cancer treatments have little impact. Increasing understanding of the pathways associated with pancreatic cancer progression has enabled the development of targeted therapy on this cancer. Heat shock proteins (HSPs) and related heat shock response (HSR) pathways control multiple important oncogenic pathways for pancreatic cancer development. Consequently, they represent promising novel targets for pancreatic cancer therapy. Various strategies have been proposed and elaborated to target HSPs/HSR in pancreatic cancer with the corresponding modulators, the details of which are highlighted in this review.
authors: Centre Interdisciplinaire de Nanoscience de Marseille, Département de Chimie, CNRS UPR 3118, 163 Avenue de Luminy, 13288 Marseille, France.
authors: Yi
authors: Y
authors: Xia
authors: Palma
authors: P
authors: Rocchi
authors: Juan L
authors: JL
authors: Iovanna
authors: Ling
authors: L
authors: Peng
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods; D018869:Heat-Shock Response / Q000187:drug effects*; D006801:Humans; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects