title: Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica.
abstract: OBJECTIVE
  To investigate the association of whole-blood fatty acids and reported intakes of fats with risk of prostate cancer (PCa).
  
  
  METHODS
  Case-control study of 209 men 40-80 years old with newly diagnosed, histologically confirmed prostate cancer and 226 cancer-free men attending the same urology clinics. Whole-blood fatty acid composition (mol%) was measured by gas chromatography and diet assessed by food frequency questionnaire.
  
  
  RESULTS
  High whole-blood oleic acid composition (tertile 3 vs. tertile 1: OR, 0.37; CI, 0.14-0.0.98) and moderate palmitic acid proportions (tertile 2: OR, 0.29; CI, 0.12-0.70) (tertile 3: OR, 0.53; CI, 0.19-1.54) were inversely related to risk of PCa, whereas men with high linolenic acid proportions were at increased likelihood of PCa (tertile 3 vs. tertile 1: OR, 2.06; 1.29-3.27). Blood myristic, stearic and palmitoleic acids were not associated with PCa. Higher intakes of dietary MUFA were inversely related to prostate cancer (tertile 3 vs. tertile 1: OR, 0.39; CI 0.16-0.92). The principal source of dietary MUFA was avocado intake. Dietary intakes of other fats were not associated with PCa.
  
  
  CONCLUSIONS
  Whole-blood and dietary MUFA reduced the risk of prostate cancer. The association may be related to avocado intakes. High blood linolenic acid was directly related to prostate cancer. These associations warrant further investigation.
authors: Department of Community Health and Psychiatry, University of the West Indies, Mona, Kingston, Jamaica, maria.jackson@uwimona.edu.jm
authors: Maria D
authors: MD
authors: Jackson
authors: Susan P
authors: SP
authors: Walker
authors: Candace M
authors: CM
authors: Simpson-Smith
authors: Carole M
authors: CM
authors: Lindsay
authors: Garret
authors: G
authors: Smith
authors: Norma
authors: N
authors: McFarlane-Anderson
authors: Franklyn I
authors: FI
authors: Bennett
authors: Kathleen C M
authors: KC
authors: Coard
authors: William D
authors: WD
authors: Aiken
authors: Trevor
authors: T
authors: Tulloch
authors: Tomlin J
authors: TJ
authors: Paul
authors: Robert L
authors: RL
authors: Wan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood; D016022:Case-Control Studies; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D005227:Fatty Acids / Q000097:blood*; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage*; D005247:Feeding Behavior; D006801:Humans; D007563:Jamaica; D008297:Male; D008875:Middle Aged; D019301:Oleic Acid / Q000097:blood*; D027421:Persea; D011471:Prostatic Neoplasms / Q000097:blood*; D012307:Risk Factors; D017962:alpha-Linolenic Acid / Q000097:blood
chemical_list: D014408:Biomarkers, Tumor; D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D017962:alpha-Linolenic Acid; D019301:Oleic Acid