title: Serum hematopoietic growth factors as diagnostic and prognostic markers of acute renal allograft rejection: a potential role for serum stem cell factor.
abstract: OBJECTIVE
  Hematopoietic growth factors (HGFs) are proliferative and chemotactic agents for hematopoietic stem cells, although their functions on renal transplantation are rarely reported. This study aimed to investigate the association of HGFs with acute T cell-mediated renal rejection.
  
  
  METHODS
  A cytokine bead array was used to analyze 10 HGFs in the sera of 32 patients with acute T cell-mediated renal allograft rejection before and during rejection and after rejection reversal. Stable renal allograft recipients (n=38) were also investigated.
  
  
  RESULTS
  Serum levels of stem cell factor (SCF), IL-3, flt3 ligand, G-CSF, M-CSF and GM-CSF were elevated during episodes of rejection compared with before and after rejection. Serum concentrations of SCF, G-CSF, flt3 ligand and IL-3 were significantly higher than in the absence of rejection. Moreover, serum SCF levels were significantly higher in patients before rejection versus stable controls.
  
  
  CONCLUSIONS
  HGFs are reported to be involved in acute T cell-mediated renal allograft rejection. A direct correlation was observed between SCF levels and the occurrence of acute renal allograft rejection which may represent an effective diagnostic and predictive biomarker for acute cellular renal allograft rejection.
authors: Transplantation Center, The 309th Hospital of Chinese People's Liberation Army, Beijing 100091, China. xg_xu2000@yahoo.com
authors: Xiaoguang
authors: X
authors: Xu
authors: Haiyan
authors: H
authors: Huang
authors: Ming
authors: M
authors: Cai
authors: Yeyong
authors: Y
authors: Qian
authors: Yong
authors: Y
authors: Han
authors: Li
authors: L
authors: Xiao
authors: Wenqiang
authors: W
authors: Zhou
authors: Xinying
authors: X
authors: Wang
authors: Bingyi
authors: B
authors: Shi
mesh_terms: D000328:Adult; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006084:Graft Rejection / Q000097:blood* / Q000175:diagnosis*; D016298:Hematopoietic Cell Growth Factors / Q000097:blood*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008954:Models, Biological; D011379:Prognosis; D012372:ROC Curve; D019089:Stem Cell Factor / Q000097:blood*
chemical_list: D015415:Biomarkers; D016298:Hematopoietic Cell Growth Factors; D019089:Stem Cell Factor