title: A statistical model of shape and bone mineral density distribution of the proximal femur for fracture risk assessment.
abstract: This work presents a statistical model of both the shape and Bone Mineral Density (BMD) distribution of the proximal femur for fracture risk assessment. The shape and density model was built from a dataset of Quantitative Computed Tomography scans of fracture patients and a control group. Principal Component Analysis and Horn's parallel analysis were used to reduce the dimensionality of the shape and density model to the main modes of variation. The input data was then used to analyze the model parameters for the optimal separation between the fracture and control group. Feature selection using the Fisher criterion determined the parameters with the best class separation, which were used in Fisher Linear Discriminant Analysis to find the direction in the parameter space that best separates the fracture and control group. This resulted in a Fisher criterion value of 6.70, while analyzing the Dual-energy X-ray Absorptiometry derived femur neck areal BMD of the same subjects resulted in a Fisher criterion value of 0.98. This indicates that a fracture risk estimation approach based on the presented model might improve upon the current standard clinical practice.
authors: Center for Computational Imaging & Simulation Technologies in Biomedicine (CISTIB), Universitat Pompeu Fabra (UPF) and CIBER-BBN, Barcelona, Spain.
authors: Tristan
authors: T
authors: Whitmarsh
authors: Karl D
authors: KD
authors: Fritscher
authors: Ludovic
authors: L
authors: Humbert
authors: Luís Miguel
authors: LM
authors: Del Rio Barquero
authors: Tobias
authors: T
authors: Roth
authors: Christian
authors: C
authors: Kammerlander
authors: Michael
authors: M
authors: Blauth
authors: Rainer
authors: R
authors: Schubert
authors: Alejandro F
authors: AF
authors: Frangi
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D000328:Adult; D000465:Algorithms; D015519:Bone Density; D003627:Data Interpretation, Statistical; D005260:Female; D005264:Femoral Fractures / Q000473:pathology*; D005272:Femur Neck / Q000473:pathology; D017102:Fracture Healing; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008875:Middle Aged; D015233:Models, Statistical; D018570:Risk Assessment; D014057:Tomography, X-Ray Computed / Q000379:methods