title: 1-hexyl-2-cyanoacrylate compound (Neucrylate) bactericidal properties.
abstract: BACKGROUND
  The need for medical grade tissue adhesives both in surgery and to treat trauma has become well established. Such a device has been developed and preliminary toxicity testing completed on a compounded cyanoacrylate (Neucrylate), and its properties have been modified so it may be used as an intravascular embolic agent. Given the high incidence of iatrogenic infections in hospital, it would be desirable to have such an implantable device that inhibits dangerous bacteria.
  
  
  METHODS
  Seven separate cultures of common bacteria were grown and exposed to Neucrylate. The impact on the exposed microorganisms was analyzed visually as well as by means of fluorescence and optical microscopy.
  
  
  RESULTS
  The device produced high degrees of antibacterial effect when exposed to gram positive bacteria whereas it had modest impact on gram negative bacteria.
authors: Valor Medical Inc, San Diego, California 92121, USA. pfriedman@valormedical.com
authors: Peter
authors: P
authors: Friedman
authors: Violeta
authors: V
authors: Casillas
authors: Charles W
authors: CW
authors: Kerber
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D003487:Cyanoacrylates / Q000737:chemistry / Q000494:pharmacology*; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods*; D014014:Tissue Adhesives / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D003487:Cyanoacrylates; D014014:Tissue Adhesives