title: Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb.
abstract: In the present study, we demonstrated that insulin is produced not only in the mammalian pancreas but also in adult neuronal cells derived from the hippocampus and olfactory bulb (OB). Paracrine Wnt3 plays an essential role in promoting the active expression of insulin in both hippocampal and OB-derived neural stem cells. Our analysis indicated that the balance between Wnt3, which triggers the expression of insulin via NeuroD1, and IGFBP-4, which inhibits the original Wnt3 action, is regulated depending on diabetic (DB) status. We also show that adult neural progenitors derived from DB animals retain the ability to give rise to insulin-producing cells and that grafting neuronal progenitors into the pancreas of DB animals reduces glucose levels. This study provides an example of a simple and direct use of adult stem cells from one organ to another, without introducing additional inductive genes.
authors: Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Science City, Japan. t.warashina@aist.go.jp
authors: Tomoko
authors: T
authors: Kuwabara
authors: Mohamedi N
authors: MN
authors: Kagalwala
authors: Yasuko
authors: Y
authors: Onuma
authors: Yuzuru
authors: Y
authors: Ito
authors: Masaki
authors: M
authors: Warashina
authors: Kazuyuki
authors: K
authors: Terashima
authors: Tsukasa
authors: T
authors: Sanosaka
authors: Kinichi
authors: K
authors: Nakashima
authors: Fred H
authors: FH
authors: Gage
authors: Makoto
authors: M
authors: Asashima
mesh_terms: D000818:Animals; D005260:Female; D020869:Gene Expression Profiling; D006624:Hippocampus / Q000166:cytology*; D007328:Insulin / Q000096:biosynthesis*; D051379:Mice; D008810:Mice, Inbred C57BL; D058953:Neural Stem Cells / Q000378:metabolism*; D009830:Olfactory Bulb / Q000166:cytology*; D051381:Rats
chemical_list: D007328:Insulin