title: Effects of dimethylsulfoxide on behavior and antioxidant enzymes response of planarian Dugesia japonica.
abstract: In this study, the toxicity, behavioral and antioxidant activity effects of dimethylsulfoxide (DMSO) on planarian Dugesia japonica were investigated. The results showed that the mortality was directly proportional to the DMSO concentration, and planarian locomotor velocity decreased as the concentration of DMSO increased. The recovery of the motility for planarians pre-exposed to DMSO was found to be time- and dose-dependent, and only those pre-exposed to 0.1-3% DMSO resulted in full recovery. The antioxidant enzymes of planarians in response to long-term DMSO stress was also altered in a time- and dose-dependent manner. Planarians revealed more tolerance to DMSO toxicity at low DMSO (0.1%) level in short- and long-term DMSO stress, in which an efficient antioxidant system was involved and the motility was not affected.
authors: School of Life Sciences, Shandong University of Technology, Zibo, People's Republic of China.
authors: Zuoqing
authors: Z
authors: Yuan
authors: Bosheng
authors: B
authors: Zhao
authors: Yu
authors: Y
authors: Zhang
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001522:Behavior, Animal / Q000187:drug effects; D002374:Catalase / Q000378:metabolism; D004121:Dimethyl Sulfoxide / Q000633:toxicity*; D007928:Lethal Dose 50; D008124:Locomotion / Q000187:drug effects*; D010932:Planarians / Q000187:drug effects* / Q000201:enzymology* / Q000378:metabolism / Q000502:physiology; D012038:Regeneration / Q000187:drug effects; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D002374:Catalase; D013482:Superoxide Dismutase; D004121:Dimethyl Sulfoxide