title: Discovery and synthesis of novel substituted benzocoumarins as orally active lipid modulating agents.
abstract: The synthesis of a series of benzocoumarin keto-enamine schiff bases is reported. The novel compounds were evaluated for their antihyperlipidemic activity in the hyperlipidemic hamster model. The compound 11 at a dose of 10 mg/kg body weight significantly lowered the plasma triglyceride levels (TG) by 70%, total cholesterol (TC) by 47%, accompanied by an increase in HDL-C/TC ratio by 80% in hyperlipidemic hamsters to a greater degree than the reference drugs atorvastatin and lovastatin.
authors: Medicinal and Process Chemistry Division, Central Drug Research Institute (CSIR-CDRI), Lucknow 226 001, India. kv_sashidhara@cdri.res.in
authors: Koneni V
authors: KV
authors: Sashidhara
authors: Manoj
authors: M
authors: Kumar
authors: Ram K
authors: RK
authors: Modukuri
authors: Anuj
authors: A
authors: Srivastava
authors: Anju
authors: A
authors: Puri
mesh_terms: D000818:Animals; D001554:Benzene / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use*; D006224:Cricetinae; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use*; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D003374:Coumarins; D000960:Hypolipidemic Agents; D012545:Schiff Bases; D014280:Triglycerides; D002784:Cholesterol; D001554:Benzene