title: Perspective: the potential of pyrazole-based compounds in medicine.
abstract: Pyrazoles are widely used as core motifs for a large number of compounds for various applications such as catalysis, agro-chemicals, building blocks of other compounds and in medicine. The attractiveness of pyrazole and its derivatives is their versatility that allows for synthesis of a series of analogues with different moieties in them, thus affecting the electronics and by extension the properties of the resultant compounds. In medicine pyrazole is found as a pharmacophore in some of the active biological molecules. While pyrazole derivatives have been extensively studied for many applications including anticancer, antimicrobial, anti-inflammatory, antiglycemic, anti-allergy and antiviral, much less has been reported on their metal counterparts in spite of the fact that metals have been shown to impart activity to ligands. Thus this perspective is intended to demonstrate the potential of pyrazole and pyrazolyl metal complexes in the areas of drug discovery and development. Several examples, that include palladium, platinum, copper, gold, zinc, cobalt, nickel, iron, copper, silver and gallium complexes, are used to bolster the above point. For the purposes of this review three areas are discussed, that is pyrazole metal complexes as: (i) anticancer, (ii) antibacterial/parasitic and (iii) antiviral agents.
authors: Advanced Materials Division, Mintek, Private Bag X3015, Randburg, 2125, South Africa. FranklineK@mintek.co.za
authors: Frankline K
authors: FK
authors: Keter
authors: James
authors: J
authors: Darkwa
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use; D056831:Coordination Complexes / Q000737:chemistry* / Q000627:therapeutic use*; D006801:Humans; D015394:Molecular Structure; D011720:Pyrazoles / Q000737:chemistry* / Q000627:therapeutic use*
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D056831:Coordination Complexes; D011720:Pyrazoles