title: FOXP3 gene polymorphisms in preeclampsia.
abstract: OBJECTIVE
  To determine whether polymorphisms in the FOXP3 gene are associated with preeclampsia.
  
  
  METHODS
  Case-control study in which 120 women with preeclampsia were compared with 120 healthy normotensive controls. Genetic variants (single nucleotide polymorphisms and microsatellites) in the FOXP3 gene were analyzed. Polymorphisms were chosen based on studies of the FOXP3 gene in other autoimmune disorders. Correction of P values for multiple comparisons was performed by using the Benjamini-Hochberg procedure.
  
  
  RESULTS
  There were no differences in the genotypes or allele frequencies in the single nucleotide polymorphisms between cases and controls. The FOXP3 GT microsatellite allele at 266 bp was less common in cases than controls (1.0% vs 5.2%, P = .0264). However, this did not remain significant after correction for multiple comparisons.
  
  
  CONCLUSIONS
  Preeclampsia is not associated with FOXP3 gene polymorphisms that have been associated with other autoimmune disorders.
authors: Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA. torri.metz@hsc.utah.edu
authors: Torri D
authors: TD
authors: Metz
authors: Lesa M
authors: LM
authors: Nelson
authors: Gregory J
authors: GJ
authors: Stoddard
authors: Robert M
authors: RM
authors: Silver
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D051858:Forkhead Transcription Factors / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D018895:Microsatellite Repeats; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors