title: [Analysis of fetal chromosomal karyotype and etiology in 252 cases of early spontaneous abortion].
abstract: OBJECTIVE
  To investigate the relationship between fetal chromosomal karyotype and early spontaneous abortion, and the effect of the environmental factors on spontaneous abortion.
  
  
  METHODS
  Choronic villi from 252 cases of missed abortion were sampled as patient group and 50 normal pregnancies as control group. Chorionic villi were cultured and karyotype analysis was performed by G-banding. Clinical information was collected.
  
  
  RESULTS
  The rate of chorion chromosome abnormality in the patient group was 58.09%, significantly higher than that in the control group (4.17%) (P<0.01). Among the 140 cases of karyotype abnormalities, 81 were trisomy, 29 were monosomy X and 17 were polyploidy, accounting for 57.86%, 20.71% and 12.14% of total abnormalities, respectively. Long time and low dose radiation exposure of the pregnant female seemed to be related with spontaneous abortion(P<0.01).
  
  
  CONCLUSIONS
  Chorion chromosome abnormality is a major reason of early spontaneous abortion and karyotype analysis of chorionic villus is of clinical importance. For pregnant women, long-term exposure to computers and television seems a risk factor for missed abortion.
authors: Southern Medical University, Shenzhen, Guangdong, People's Republic of China.
authors: Hua-kun
authors: HK
authors: Zhang
authors: Fu-wei
authors: FW
authors: Luo
authors: Qian
authors: Q
authors: Geng
authors: Juan
authors: J
authors: Li
authors: Qing-zhi
authors: QZ
authors: Liu
authors: Wu-bin
authors: WB
authors: Chen
authors: Fang
authors: F
authors: Li
authors: Jian-sheng
authors: JS
authors: Xie
mesh_terms: D000030:Abortion, Missed / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002824:Chorionic Villi / Q000378:metabolism; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D011247:Pregnancy; D012307:Risk Factors; D055815:Young Adult