title: Colorectal Oncogenesis and Inflammation in a Rat Model Based on Chronic Inflammation due to Cycling DSS Treatments.
abstract: Inflammation is known to be linked with development of colorectal cancer, and the aim was to assess the malignant potential and degree of inflammation in a dextran-sulphate-sodium-(DSS-) induced cyclic colonic tumour model (CTM) in rats and to compare it with the azoxymethane-(AOM-) induced CTM model. Tumours developed in both groups, although, in the DSS group, the colonic mucosa appeared edematous and the number of haemorrhagic erosions and quantity of dysplastic lesions were higher as well as the mucosal concentration of myeloperoxidase and faecal viable count of Enterobacteriaceae. The livers were affected as evaluated by steatosis, parenchymal loss, haemorrhage, and inflammatory infiltrations, and higher proportions of acetate and lower proportions of butyrate in colonic content were found. The DSS model seems to mimic the clinical situation and may be valuable for investigation of inflammation-related dysplasia and colon cancer, as well as for altered liver function by endogenous inflammatory mediators.
authors: Food Hygiene, Division of Applied Nutrition and Food Chemistry, Lund University, 221 00 Lund, Sweden.
authors: Asa
authors: A
authors: Håkansson
authors: Camilla
authors: C
authors: Bränning
authors: Göran
authors: G
authors: Molin
authors: Diya
authors: D
authors: Adawi
authors: Marie-Louise
authors: ML
authors: Hagslätt
authors: Margareta
authors: M
authors: Nyman
authors: Bengt
authors: B
authors: Jeppsson
authors: Siv
authors: S
authors: Ahrné