title: 10T024A, a new phenazine derivative, as a radical scavenger and a prostaglandin, leukotriene release suppressor.
abstract: We identified a new radical scavenger, 10T024A (C(15)H(12)N(2)O(4)), from a culture of the Streptomyces sp. Spectroscopic elucidation indicated that this compound is a new phenazine derivative. 10T024A showed radical-scavenging activity with an ED(50) of 125 µM. Moreover, it showed prostaglandin D(2) (PGD(2)) and leukotriene B(4) (LTB(4)) release suppressive activity in rat basophilic leukemia (RBL-2H3) cells, at IC(50): 8 µM and 10 µM respectively.
authors: School of Food, Agricultural, and Environmental Sciences, Miyagi University, Sendai, Miyagi, Japan. komoda@myu.ac.jp
authors: Toshikazu
authors: T
authors: Komoda
authors: Yuta
authors: Y
authors: Tamiya
authors: Masazumi
authors: M
authors: Nishikawa
mesh_terms: D000818:Animals; D001713:Biphenyl Compounds / Q000737:chemistry; D045744:Cell Line, Tumor; D016166:Free Radical Scavengers / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015289:Leukotrienes / Q000378:metabolism*; D010619:Phenazines / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D010851:Picrates / Q000737:chemistry; D011453:Prostaglandins / Q000378:metabolism*; D051381:Rats; D013302:Streptomyces / Q000254:growth & development / Q000378:metabolism
chemical_list: C569937:10T024A compound; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D015289:Leukotrienes; D010619:Phenazines; D010851:Picrates; D011453:Prostaglandins; C004931:1,1-diphenyl-2-picrylhydrazyl