title: Ulcerative colitis complicated with primary biliary cirrhosis.
abstract: We report a patient who developed ulcerative colitis during the course of primary biliary cirrhosis (PBC). PBC was diagnosed by liver histology when the patient was 31 years old, at which time no symptoms were observed. At 45 years of age, the patient complained of bloody diarrhea and abdominal pain, and she was diagnosed with ulcerative colitis by colonoscopy and histological examination. The patient had HLA-DRB1(*)1502 and (*)0802, which are associated with both diseases. Ulcerative colitis should be considered in the differential diagnosis of bowel disease in patients with PBC. The possible genetic associations between 2 diseases are also discussed.
authors: Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan.
authors: Fujimasa
authors: F
authors: Tada
authors: Masanori
authors: M
authors: Abe
authors: Hiroaki
authors: H
authors: Nunoi
authors: Nobuaki
authors: N
authors: Azemoto
authors: Toshie
authors: T
authors: Mashiba
authors: Shinya
authors: S
authors: Furukawa
authors: Teru
authors: T
authors: Kumagi
authors: Hidehiro
authors: H
authors: Murakami
authors: Yoshio
authors: Y
authors: Ikeda
authors: Bunzo
authors: B
authors: Matsuura
authors: Yoichi
authors: Y
authors: Hiasa
authors: Morikazu
authors: M
authors: Onji
mesh_terms: D000328:Adult; D003093:Colitis, Ulcerative / Q000209:etiology*; D005260:Female; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000150:complications*