title: Protective effect of vanillin against carbon tetrachloride (CCl₄)-induced oxidative brain injury in rats.
abstract: This study investigated the protective effects of vanillin against acute brain damage induced by carbon tetrachloride (CCl₄) in rats. The study was performed on 32 male rats divided into four groups: a control group, vanillin group ([Va] 150 mg/kg/day, intraperitoneally [i.p.]) and CCl₄ toxication groups received a single injection of CCl₄ (1 ml/kg, i.p.; CCl₄ and Va + CCl₄ groups). The degree of protection in brain tissue was evaluated by the levels of malondialdehyde (MDA), glutathione (GSH), superoxide dismutase, glutathione transferase, glutathione peroxidase and nitric oxide (NO). Vanillin showed a significant brain-protective effect by decreasing the level of lipid peroxidation and NO₂ and elevated the activities of antioxidative enzymes and level of GSH. Consequently vanillin blocked oxidative brain damage induced by CCl₄ in rats.
authors: Animal Physiology Laboratory, University of Sfax, Sfax, Tunisia. mohamed.makni@gmail.com
authors: Mohamed
authors: M
authors: Makni
authors: Yassine
authors: Y
authors: Chtourou
authors: Mohamed
authors: M
authors: Barkallah
authors: Hamadi
authors: H
authors: Fetoui
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000704:Analysis of Variance; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001547:Benzaldehydes / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects*; D001930:Brain Injuries / Q000139:chemically induced* / Q000378:metabolism / Q000517:prevention & control*; D002251:Carbon Tetrachloride / Q000633:toxicity*; D005982:Glutathione Transferase / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D009569:Nitric Oxide / Q000032:analysis; D018384:Oxidative Stress / Q000187:drug effects*; D010088:Oxidoreductases / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D001547:Benzaldehydes; D009569:Nitric Oxide; D008315:Malondialdehyde; C100058:vanillin; D002251:Carbon Tetrachloride; D010088:Oxidoreductases; D005982:Glutathione Transferase; D000110:Acetylcholinesterase