title: Haematopoietic SCT in severe autoimmune diseases: updated guidelines of the European Group for Blood and Marrow Transplantation.
abstract: In 1997, the first consensus guidelines for haematopoietic SCT (HSCT) in autoimmune diseases (ADs) were published, while an international coordinated clinical programme was launched. These guidelines provided broad principles for the field over the following decade and were accompanied by comprehensive data collection in the European Group for Blood and Marrow Transplantation (EBMT) AD Registry. Subsequently, retrospective analyses and prospective phase I/II studies generated evidence to support the feasibility, safety and efficacy of HSCT in several types of severe, treatment-resistant ADs, which became the basis for larger-scale phase II and III studies. In parallel, there has also been an era of immense progress in biological therapy in ADs. The aim of this document is to provide revised and updated guidelines for both the current application and future development of HSCT in ADs in relation to the benefits, risks and health economic considerations of other modern treatments. Patient safety considerations are central to guidance on patient selection and HSCT procedural aspects within appropriately experienced and Joint Accreditation Committee of International Society for Cellular Therapy and EBMT accredited centres. A need for prospective interventional and non-interventional studies, where feasible, along with systematic data reporting, in accordance with EBMT policies and procedures, is emphasized.
authors: Department of Haematology, Sheffield Teaching Hospitals NHS Trust, Sheffield, UK. john.snowden@sth.nhs.uk
authors: J A
authors: JA
authors: Snowden
authors: R
authors: R
authors: Saccardi
authors: M
authors: M
authors: Allez
authors: S
authors: S
authors: Ardizzone
authors: R
authors: R
authors: Arnold
authors: R
authors: R
authors: Cervera
authors: C
authors: C
authors: Denton
authors: C
authors: C
authors: Hawkey
authors: M
authors: M
authors: Labopin
authors: G
authors: G
authors: Mancardi
authors: R
authors: R
authors: Martin
authors: J J
authors: JJ
authors: Moore
authors: J
authors: J
authors: Passweg
authors: C
authors: C
authors: Peters
authors: M
authors: M
authors: Rabusin
authors: M
authors: M
authors: Rovira
authors: J M
authors: JM
authors: van Laar
authors: D
authors: D
authors: Farge
mesh_terms: D001327:Autoimmune Diseases / Q000191:economics / Q000628:therapy*; D017321:Clinical Trials, Phase I as Topic; D017322:Clinical Trials, Phase II as Topic; D005062:European Union; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000191:economics / Q000379:methods* / Q000592:standards*; D006801:Humans; D008297:Male; D012307:Risk Factors; D012449:Safety; D012720:Severity of Illness Index