title: Clinical utility of (18)F-fluoride PET/CT in benign and malignant bone diseases.
abstract: (18)F labeled sodium fluoride is a positron-emitting, bone seeking agent with more favorable skeletal kinetics than conventional phosphate and diphosphonate compounds. With the expanding clinical usage of PET/CT, there is renewed interest in using (18)F-fluoride PET/CT for imaging bone diseases. Growing evidence indicates that (18)F fluoride PET/CT offers increased sensitivity, specificity, and diagnostic accuracy in evaluating metastatic bone disease compared to (99m)Tc based bone scintigraphy. National Oncologic PET Registry (NOPR) has expanded coverage for (18)F sodium fluoride PET scans since February 2011 for the evaluation of osseous metastatic disease. In this article, we reviewed the pharmacological characteristics of sodium fluoride, as well as the clinical utility of PET/CT using (18)F-fluoride in both benign and malignant bone disorders.
authors: VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA.
authors: Yuxin
authors: Y
authors: Li
authors: Christiaan
authors: C
authors: Schiepers
authors: Ralph
authors: R
authors: Lake
authors: Simin
authors: S
authors: Dadparvar
authors: Gholam R
authors: GR
authors: Berenji
mesh_terms: D001847:Bone Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D005462:Fluorine Radioisotopes; D006801:Humans; D007091:Image Processing, Computer-Assisted; D064847:Multimodal Imaging / Q000379:methods*; D049268:Positron-Emission Tomography; D011877:Radionuclide Imaging / Q000379:methods; D012680:Sensitivity and Specificity; D012969:Sodium Fluoride / Q000378:metabolism; D014057:Tomography, X-Ray Computed
chemical_list: D005462:Fluorine Radioisotopes; D012969:Sodium Fluoride