title: Malaria hidden in a patient with diffuse large-B-cell lymphoma and sickle-cell trait.
abstract: We report a case of an African patient with sickle cell trait who was diagnosed in Spain with B-cell lymphoma. Blood smears were negative for malaria, and no plasmodium antigens were detected in the blood. To treat his lymphoma, the patient underwent chemotherapy and autologous stem cell transplantation. Following a splenectomy due to a worsening condition, he developed clinical malaria with detectable parasitemia. This case suggests that the humoral response and parasite removal by the spleen may afford protection from overt disease and may even help maintain subclinical human reservoirs of the disease.
authors: Department of Biochemistry and Molecular Biology IV and Instituto de Investigación Hospital 12 de Octubre, Universidad Complutense de Madrid, Ciudad Universitaria, 28040 Madrid, Spain.  jmbau@vet.ucm.es.
authors: María
authors: M
authors: Linares
authors: Enriqueta
authors: E
authors: Albizua
authors: Darío
authors: D
authors: Méndez
authors: José M
authors: JM
authors: Rubio
authors: Alejandra
authors: A
authors: Martínez-Serna
authors: Miguel A
authors: MA
authors: Martínez
authors: Efren
authors: E
authors: Salto
authors: Antonio
authors: A
authors: Puyet
authors: Amalia
authors: A
authors: Diez
authors: Joaquin
authors: J
authors: Martinez-López
authors: José M
authors: JM
authors: Bautista
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D016703:Equatorial Guinea; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D008288:Malaria / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018512:Parasitemia / Q000175:diagnosis / Q000469:parasitology; D010961:Plasmodium / Q000302:isolation & purification; D012805:Sickle Cell Trait / Q000150:complications*; D013030:Spain; D013154:Spleen / Q000276:immunology; D013156:Splenectomy; D033581:Stem Cell Transplantation; D014182:Transplantation, Autologous
chemical_list: D000970:Antineoplastic Agents