title: Novel hydrogel particles and their IPN films as drug delivery systems with antibacterial properties.
abstract: Poly(acrylonitrile) (p(AN))-based materials such poly(acrylonitrile-co-(3-acrylamidopropyl)-trimethylammonium chloride (p(AN-co-APTMACl)), poly(acrylonitrile-co-4-viniyl pyridine) (p(AN-co-4-VP)) and poly(acrylonitrile-co-N-isopropylacrylamide) (p(AN-co-NIPAM)) core-shell nanoparticles were prepared. The core materials, AN, in p(AN-co-4-VP) nanoparticles, were amidoximated and the shell materials, 4-VP, were quaternized to generate p(AN-co-4-VP)(+) and p(AN-co-4-VP)(++), single and double positively charged core-shell nanoparticles, respectively. Furthermore, interpenetrating microgels-hydrogel (IPN) polymeric networks were prepared by mixing double quaternized p(AN-co-4-VP)(++) core-shell particles with acrylamide (AAm) and 2-hydroxyethylmethacrylate (HEMA) before polymerization. A model drug, fluorescein sodium salt (FSS) was used in absorption/release studies from these IPNs. Moreover, the prepared and chemically modified particles were tested against Staphylococcus aureus ATCC6538, Pseduomonas aeruginosa ATCC9027, Bacillus subtilis ATCC6633, and Escherichia coli ATCC8739, and found that some of these particles had antibacterial properties against tested bacteria.
authors: School of Medicine, Department of Pharmacology, Canakkale Onsekiz Mart University, Canakkale, Turkey.
authors: Coskun
authors: C
authors: Silan
authors: Alper
authors: A
authors: Akcali
authors: Muşerref Tatman
authors: MT
authors: Otkun
authors: Nilgun
authors: N
authors: Ozbey
authors: Sultan
authors: S
authors: Butun
authors: Ozgur
authors: O
authors: Ozay
authors: Nurettin
authors: N
authors: Sahiner
mesh_terms: D000180:Acrylic Resins; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects / Q000502:physiology; D016503:Drug Delivery Systems; D004926:Escherichia coli / Q000187:drug effects / Q000502:physiology; D020100:Hydrogels; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000502:physiology; D000644:Quaternary Ammonium Compounds; D013211:Staphylococcus aureus / Q000187:drug effects / Q000502:physiology
chemical_list: D000180:Acrylic Resins; D000900:Anti-Bacterial Agents; D020100:Hydrogels; D000644:Quaternary Ammonium Compounds; C000606552:poly(acrylonitrile-co-(3-acrylamidopropyl)-trimethylammonium chloride)