title: Amplifying vibrational circular dichroism by manipulation of the electronic manifold.
abstract: Vibrational circular dichroism is a powerful technique to study the stereochemistry of chiral molecules, but often suffers from small signal intensities. Electrochemical modulation of the energies of the electronically excited state manifold is now demonstrated to lead to an order of magnitude enhancement of the differential absorption. Quantum-chemical calculations show that increased mixing between ground and excited states is at the origin of this amplification.
authors: Van 't Hoff Institute for Molecular Sciences, University of Amsterdam, Science Park 904, 1089 XH, The Netherlands.
authors: Sérgio R
authors: SR
authors: Domingos
authors: Matthijs R
authors: MR
authors: Panman
authors: Bert H
authors: BH
authors: Bakker
authors: Frantisek
authors: F
authors: Hartl
authors: Wybren J
authors: WJ
authors: Buma
authors: Sander
authors: S
authors: Woutersen
mesh_terms: D002942:Circular Dichroism; D055664:Electrochemical Techniques; D004583:Electrons; D007546:Isoquinolines / Q000737:chemistry; D010084:Oxidation-Reduction; D011789:Quantum Theory; D013237:Stereoisomerism
chemical_list: D007546:Isoquinolines; C039109:isoquinoline