title: Phenotypic changes in artemisinin-resistant Plasmodium falciparum lines in vitro: evidence for decreased sensitivity to dormancy and growth inhibition.
abstract: The appearance of Plasmodium falciparum parasites with decreased in vivo sensitivity but no measurable in vitro resistance to artemisinin has raised the urgent need to characterize the artemisinin resistance phenotype. Changes in the temporary growth arrest (dormancy) profile of parasites may be one aspect of this phenotype. In this study, we investigated the link between dormancy and resistance, using artelinic acid (AL)-resistant parasites. Our results demonstrate that the AL resistance phenotype has (i) decreased sensitivity of mature-stage parasites, (ii) decreased sensitivity of the ring stage to the induction of dormancy, and (iii) a faster recovery from dormancy.
authors: Drug Resistance and Diagnostics, Australian Army Malaria Institute, Brisbane, Australia.
authors: Franka
authors: F
authors: Teuscher
authors: Nanhua
authors: N
authors: Chen
authors: Dennis E
authors: DE
authors: Kyle
authors: Michelle L
authors: ML
authors: Gatton
authors: Qin
authors: Q
authors: Cheng
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D037621:Artemisinins / Q000494:pharmacology*; D018929:Cell Culture Techniques; D004351:Drug Resistance; D004912:Erythrocytes / Q000187:drug effects / Q000469:parasitology; D005838:Genotype; D006801:Humans; D020128:Inhibitory Concentration 50; D008018:Life Cycle Stages / Q000187:drug effects*; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000378:metabolism / Q000469:parasitology; D008853:Microscopy; D021261:Parasitic Sensitivity Tests; D010641:Phenotype; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D012008:Recurrence
chemical_list: D000962:Antimalarials; D037621:Artemisinins; C062768:artelinic acid; C031327:artemisinin