title: Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001-2006.
abstract: Recent reports describe increasing incidence of non-Aspergillus mold infections in hematopoietic cell transplant (HCT) and solid organ transplant (SOT) recipients. To investigate the epidemiology of infections with Mucorales, Fusarium spp., and Scedosporium spp. molds, we analyzed data from the Transplant-Associated Infection Surveillance Network, 23 transplant centers that conducted prospective surveillance for invasive fungal infections during 2001-2006. We identified 169 infections (105 Mucorales, 37 Fusarium spp., and 27 Scedosporium spp.) in 169 patients; 124 (73.4%) were in HCT recipients, and 45 (26.6%) were in SOT recipients. The crude 90-day mortality rate was 56.6%. The 12-month mucormycosis cumulative incidence was 0.29% for HCT and 0.07% for SOT. Mucormycosis incidence among HCT recipients varied widely, from 0.08% to 0.69%, with higher incidence in cohorts receiving transplants during 2003 and 2004. Non-Aspergillus mold infections continue to be associated with high mortality rates. The incidence of mucormycosis in HCT recipients increased substantially during the surveillance period.
authors: Centers for Disease Control and Prevention, Atlanta, Georgia, USA. bpark1@cdc.gov
authors: Benjamin J
authors: BJ
authors: Park
authors: Peter G
authors: PG
authors: Pappas
authors: Kathleen A
authors: KA
authors: Wannemuehler
authors: Barbara D
authors: BD
authors: Alexander
authors: Elias J
authors: EJ
authors: Anaissie
authors: David R
authors: DR
authors: Andes
authors: John W
authors: JW
authors: Baddley
authors: Janice M
authors: JM
authors: Brown
authors: Lisa M
authors: LM
authors: Brumble
authors: Alison G
authors: AG
authors: Freifeld
authors: Susan
authors: S
authors: Hadley
authors: Loreen
authors: L
authors: Herwaldt
authors: James I
authors: JI
authors: Ito
authors: Carol A
authors: CA
authors: Kauffman
authors: G Marshall
authors: GM
authors: Lyon
authors: Kieren A
authors: KA
authors: Marr
authors: Vicki A
authors: VA
authors: Morrison
authors: Genovefa
authors: G
authors: Papanicolaou
authors: Thomas F
authors: TF
authors: Patterson
authors: Trish M
authors: TM
authors: Perl
authors: Mindy G
authors: MG
authors: Schuster
authors: Randall
authors: R
authors: Walker
authors: John R
authors: JR
authors: Wingard
authors: Thomas J
authors: TJ
authors: Walsh
authors: Dimitrios P
authors: DP
authors: Kontoyiannis
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D009894:Opportunistic Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D014180:Transplantation / Q000009:adverse effects; D014481:United States / Q000453:epidemiology
chemical_list: D000935:Antifungal Agents