title: A new class of adenylate kinase in methanogens is related to uridylate kinase.
abstract: The protein derived from the Methanocaldococcus jannaschii MJ0458 gene is annotated as a δ-1-pyrroline 5-carboxylate synthetase and is predicted to be related to aspartokinase and uridylate kinase. Analysis of the predicted protein sequence indicated that it is a unique kinase with few similarities to either uridylate or adenylate kinase. Here, we report that the MJ0458 gene product is a second type of archaeal adenylate kinase, AdkB. This enzyme is different from the established archaeal-specific adenylate kinase in both sequence and predicted tertiary structure.
authors: Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
authors: Laura L
authors: LL
authors: Grochowski
authors: Kaitlin
authors: K
authors: Censky
authors: Huimin
authors: H
authors: Xu
authors: Robert H
authors: RH
authors: White
mesh_terms: D000249:Adenosine Monophosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000263:Adenylate Kinase / Q000737:chemistry / Q000378:metabolism*; D001105:Archaea / Q000201:enzymology; D017016:Methanococcaceae / Q000145:classification / Q000201:enzymology*; D009703:Nucleoside-Phosphate Kinase / Q000737:chemistry / Q000378:metabolism*; D010766:Phosphorylation; D010802:Phylogeny; D013379:Substrate Specificity
chemical_list: D000249:Adenosine Monophosphate; D000255:Adenosine Triphosphate; C023276:uridine monophosphate kinase; D000263:Adenylate Kinase; D009703:Nucleoside-Phosphate Kinase