title: The influence of chlorhexidine on the remineralization of demineralized dentine.
abstract: OBJECTIVE
  To examine the differences in the amounts of bound chlorhexidine (CHX) on demineralized dentine blocks and to investigate the different aspects of remineralization of demineralized dentine according to different concentrations of CHX.
  
  
  METHODS
  Dentine blocks (2 mm × 7 mm × 0.9 m) were demineralized in 0.2 M formic acid solution. Amount of bound CHX on the dentine blocks was measured on a spectrophotometer after the dentine block was soaked in 0.02%, 0.2%, or 2% CHX solutions for 1 min. The change in elastic modulus of dentine block stored in simulated body fluids was measured at 0 (baseline), 2, 4, and 6 weeks after storage. The micromorphological aspects of the samples were observed using a field emission scanning electron microscope after 6 weeks of storage.
  
  
  RESULTS
  Higher concentrations of CHX caused a greater amount of CHX to bind to the dentine blocks (p<0.05). The group treated with the higher concentration of CHX had a smaller decrease in the elastic modulus at 2 weeks and a greater increase at 4 and 6 weeks. Dentine specimens with the 0.2% and 2% CHX had a greater deposition of granular minerals along the collagen fibrils compared to the 0.02% CHX-treated group.
  
  
  CONCLUSIONS
  The application of the 0.2% and 2% CHX seemed to be effective in promoting the remineralization of demineralized dentine.
  
  
  CONCLUSIONS
  The application of the 0.2% and 2% CHX positively influences on the dentine remineralization.
authors: Department of Conservative Dentistry, School of Dentistry, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul, 130-701, Republic of Korea.
authors: Duck-Su
authors: DS
authors: Kim
authors: Jongryul
authors: J
authors: Kim
authors: Kyoung-Kyu
authors: KK
authors: Choi
authors: Sun-Young
authors: SY
authors: Kim
mesh_terms: D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000494:pharmacology*; D002710:Chlorhexidine / Q000008:administration & dosage / Q000494:pharmacology*; D003094:Collagen / Q000187:drug effects / Q000648:ultrastructure; D003799:Dental Stress Analysis / Q000295:instrumentation; D003804:Dentin / Q000187:drug effects* / Q000648:ultrastructure; D055119:Elastic Modulus; D005561:Formates / Q000009:adverse effects; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D008903:Minerals / Q000032:analysis; D013053:Spectrophotometry; D013696:Temperature; D013997:Time Factors; D017001:Tooth Demineralization / Q000503:physiopathology* / Q000517:prevention & control; D014089:Tooth Remineralization
chemical_list: D000891:Anti-Infective Agents, Local; D005561:Formates; D008903:Minerals; C030544:formic acid; D003094:Collagen; D002710:Chlorhexidine