title: Regulation of nucleotide excision repair through ubiquitination.
abstract: Nucleotide excision repair (NER) is the most versatile DNA-repair pathway in all organisms. While bacteria require only three proteins to complete the incision step of NER, eukaryotes employ about 30 proteins to complete the same step. Here we summarize recent studies demonstrating that ubiquitination, a post-translational modification, plays critical roles in regulating the NER activity either dependent on or independent of ubiquitin-proteolysis. Several NER components have been shown as targets of ubiquitination while others are actively involved in the ubiquitination process. We argue through this analysis that ubiquitination serves to coordinate various steps of NER and meanwhile connect NER with other related pathways to achieve the efficient global DNA-damage response.
authors: Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, Canada.
authors: Jia
authors: J
authors: Li
authors: Audesh
authors: A
authors: Bhat
authors: Wei
authors: W
authors: Xiao
mesh_terms: D004249:DNA Damage / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics*; D045643:DNA Repair Enzymes / Q000737:chemistry* / Q000235:genetics*; D011499:Protein Processing, Post-Translational / Q000235:genetics; D059748:Proteolysis; D025801:Ubiquitin / Q000737:chemistry*; D054875:Ubiquitination / Q000235:genetics*
chemical_list: D025801:Ubiquitin; D045643:DNA Repair Enzymes