title: Human cancer long non-coding RNA transcriptomes.
abstract: Once thought to be a part of the 'dark matter' of the genome, long non-coding RNAs (lncRNAs) are emerging as an integral functional component of the mammalian transcriptome. LncRNAs are a novel class of mRNA-like transcripts which, despite no known protein-coding potential, demonstrate a wide range of structural and functional roles in cellular biology. However, the magnitude of the contribution of lncRNA expression to normal human tissues and cancers has not been investigated in a comprehensive manner. In this study, we compiled 272 human serial analysis of gene expression (SAGE) libraries to delineate lncRNA transcription patterns across a broad spectrum of normal human tissues and cancers. Using a novel lncRNA discovery pipeline we parsed over 24 million SAGE tags and report lncRNA expression profiles across a panel of 26 different normal human tissues and 19 human cancers. Our findings show extensive, tissue-specific lncRNA expression in normal tissues and highly aberrant lncRNA expression in human cancers. Here, we present a first generation atlas for lncRNA profiling in cancer.
authors: British Columbia Cancer Agency Research Centre, Vancouver, British Columbia, Canada. egibb@bccrc.ca
authors: Ewan A
authors: EA
authors: Gibb
authors: Emily A
authors: EA
authors: Vucic
authors: Katey S S
authors: KS
authors: Enfield
authors: Greg L
authors: GL
authors: Stewart
authors: Kim M
authors: KM
authors: Lonergan
authors: Jennifer Y
authors: JY
authors: Kennett
authors: Daiana D
authors: DD
authors: Becker-Santos
authors: Calum E
authors: CE
authors: MacAulay
authors: Stephen
authors: S
authors: Lam
authors: Carolyn J
authors: CJ
authors: Brown
authors: Wan L
authors: WL
authors: Lam
mesh_terms: D002877:Chromosomes, Human / Q000235:genetics; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D015723:Gene Library; D015894:Genome, Human / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D009928:Organ Specificity / Q000235:genetics; D022661:RNA, Untranslated / Q000235:genetics* / Q000378:metabolism; D059467:Transcriptome
chemical_list: D022661:RNA, Untranslated