title: Investigation of thyroid function and blood pressure in school-aged subjects without overt thyroid disease.
abstract: This study was performed to ascertain whether a relationship exists between thyroid function and blood pressure in school-aged Chinese subjects without overt thyroid disease. A cross-sectional survey of 880 subjects (541 females and 339 males) aged 7-18 years in Bengbu, Anhui province was conducted. The investigation, which was based on a stratified random cluster sampling method, included a questionnaire and measurements of blood pressure, height, and body weight. Fasting blood samples were taken for measurements of thyroid-stimulating hormone (TSH), free 3,5,3'-triiodothyronine (FT(3)) and free thyroxine (FT(4)). Serum TSH and FT(3) were positively correlated with systolic and diastolic blood pressure Z scores (SBP-Z and DBP-Z) even after adjusting for body mass index (BMI) (P < 0.05) but no correlation was observed between FT(4) and SBP-Z or DBP-Z after comparable adjustments (P > 0.05). SBP-Z and DBP-Z in subjects with subclinical hypothyroidism were significant higher than in euthyroid subjects (P < 0.05). Both SBP-Z and DBP-Z increased linearly with TSH concentration in boys after adjusting BMI (P < 0.05); however, a similar linear trend was not observed in girls. Our findings support the hypothesis that elevated TSH and FT(3) concentrations increase blood pressure in school-aged Chinese subjects without overt thyroid disease; this increase may be even more significant in boys.
authors: Department of Endocrinology, First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Rd, Nanjing, 210029, China.
authors: Huanhuan
authors: H
authors: Chen
authors: Qian
authors: Q
authors: Xi
authors: Hao
authors: H
authors: Zhang
authors: Bin
authors: B
authors: Song
authors: Xiaoyun
authors: X
authors: Liu
authors: Xiaodong
authors: X
authors: Mao
authors: Jie
authors: J
authors: Li
authors: Hongmei
authors: H
authors: Shen
authors: Wei
authors: W
authors: Tang
authors: Jiaming
authors: J
authors: Zhang
authors: Zhiguo
authors: Z
authors: Wang
authors: Yu
authors: Y
authors: Duan
authors: Chao
authors: C
authors: Liu
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology*; D002648:Child; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000208:ethnology* / Q000503:physiopathology*; D008297:Male; D012189:Retrospective Studies; D012727:Sex Characteristics; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000502:physiology*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D015415:Biomarkers; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine