title: Three-year clinical follow-up of an unselected patient population treated with the genous endothelial progenitor cell capturing stent.
abstract: BACKGROUND
  We assessed the 3-year clinical outcome in our single-center cohort of mainly unselected patients treated with the endothelial progenitor cell capturing stent (ECS). The ECS is coated with CD34+ antibodies specifically targeting the circulating endothelial progenitor cells population to accelerate endothelialization that in turn may prevent the occurrence of in-stent restenosis and stent thrombosis (ST).
  
  
  METHODS
  All patients in our study had coronary artery lesions that were treated with an ECS. The majority of patients had complex lesions with an estimated high risk of restenosis.
  
  
  RESULTS
  A total of 405 patients were enrolled. The primary end-point of target lesion failure (TLF) was defined as the composite of cardiac death, myocardial infarction, and target lesion revascularization (TLR). At 3 years, TLF was 18.3% and TLR was 14.2%. Early ST occurred in 2 patients. No cases of late and very late definite ST were reported.
  
  
  CONCLUSIONS
  This single-center study demonstrates the safety at 3 years of the ECS in an unselected patient population, including a fair number of patients with complex lesions, reflecting daily practice. Our data compare well with drug-eluting stent and bare metal stent registries enrolling unselected patient populations. Importantly, in our analysis, no cases of late or very late definite ST were reported.
authors: Department of Cardiology, Academic Medical Center, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands.
authors: Margo
authors: M
authors: Klomp
authors: Marcel A M
authors: MA
authors: Beijk
authors: Peter
authors: P
authors: Damman
authors: Pier
authors: P
authors: Woudstra
authors: Karel T
authors: KT
authors: Koch
authors: Jan G P
authors: JG
authors: Tijssen
authors: Robbert J
authors: RJ
authors: de Winter
mesh_terms: D018952:Antigens, CD34 / Q000276:immunology*; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000517:prevention & control*; D042783:Endothelial Cells / Q000166:cytology*; D004730:Endothelium, Vascular / Q000166:cytology*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D013234:Stem Cells / Q000166:cytology*; D015607:Stents; D013997:Time Factors
chemical_list: D018952:Antigens, CD34