title: Detection of an unusual van genotype in a vancomycin-resistant Enterococcus faecium hospital isolate.
abstract: We highlight the detection of a rare vanM genotype in Enterococcus faecium. This isolate exhibited a VanB phenotype, with high levels of resistance to vancomycin (MIC, >256 mg/liter) and susceptibility to teicoplanin (MIC, 1 mg/liter). It was, however, vanB negative by PCR. Further screening for other van loci revealed the presence of a complete vanM operon.
authors: Department of Laboratory Medicine, National University Hospital, Singapore 119074, Republic of Singapore. jeanette_teo@nuhs.edu.sg
authors: Jeanette W P
authors: JW
authors: Teo
authors: Prabha
authors: P
authors: Krishnan
authors: Roland
authors: R
authors: Jureen
authors: Raymond T P
authors: RT
authors: Lin
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D016984:Enterococcus faecium / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D005260:Female; D005838:Genotype; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology*; D006761:Hospitals; D006801:Humans; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D008969:Molecular Sequence Data; D010641:Phenotype; D017422:Sequence Analysis, DNA; D017334:Teicoplanin / Q000494:pharmacology; D014640:Vancomycin / Q000494:pharmacology; D020713:Vancomycin Resistance
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D017334:Teicoplanin; D014640:Vancomycin