title: [Muscle catabolism in patients with chronic obstructive pulmonary disease].
abstract: OBJECTIVE
  Chronic obstructive pulmonary disease (COPD) is accompanied by muscle involvement. Pseudouridine, a catabolite of RNA, has been used in other conditions to assess muscle catabolism. We have examined the excretion of pseudouridine in patients with different stages of COPDs evolution.
  
  
  METHODS
  We have defined four population groups: control group (without disease), chronic bronchitis group, emerging COPD group, and advanced COPD group. Pseudouridine was determined by high performance liquid chromatography,
  
  
  RESULTS
  Pseudouridine extraction (pseudouridine/creatinine ratio) was (mean+19.9 (6.6) μmol/mmol in control group and was found to be very increased in all the patients with pulmonary condition: chronic bronchitis, 44.1 (60.75) μmol/mmol, 81.6 (56.8) μmol/mmol in emerging COPD group and 140.1 (68) μmol/mmol in advanced COPD for all the comparisons with normal subjects and among patients with lung disease). Age and gender did not affect pseudouridine excretion.
  
  
  CONCLUSIONS
  The urinary excretion of pseudouridine is increased in chronic bronchitis and COPD and is related to disease stage. Its excretion is independent of age and gender.
authors: Centro de instrucción de Medicina Aeroespacial-CIMA, Hospital Central de la Defensa Gómez Ulla, Madrid, España. pmonalv@oc.mde
authors: P
authors: P
authors: Montenegro Álvarez de Tejera
authors: M A
authors: MA
authors: Cabanes-Mariscal
authors: C
authors: C
authors: Gutiérrez-Ortega
authors: J
authors: J
authors: Medina Font
authors: M C
authors: MC
authors: Villa-Corbatón
authors: J
authors: J
authors: Gómez de Terreros
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000652:urine; D029481:Bronchitis, Chronic / Q000503:physiopathology / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D003404:Creatinine / Q000652:urine; D003430:Cross-Sectional Studies; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism*; D011560:Pseudouridine / Q000652:urine*; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology / Q000652:urine*
chemical_list: D015415:Biomarkers; D011560:Pseudouridine; D003404:Creatinine