title: Development of a highly selective fluorescence probe for hydrogen sulfide.
abstract: Hydrogen sulfide (H(2)S) has recently been identified as a biological response modifier. Here, we report the design and synthesis of a novel fluorescence probe for H(2)S, HSip-1, utilizing azamacrocyclic copper(II) ion complex chemistry to control the fluorescence. HSip-1 showed high selectivity and high sensitivity for H(2)S, and its potential for biological applications was confirmed by employing it for fluorescence imaging of H(2)S in live cells.
authors: Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors: Kiyoshi
authors: K
authors: Sasakura
authors: Kenjiro
authors: K
authors: Hanaoka
authors: Norihiro
authors: N
authors: Shibuya
authors: Yoshinori
authors: Y
authors: Mikami
authors: Yuka
authors: Y
authors: Kimura
authors: Toru
authors: T
authors: Komatsu
authors: Tasuku
authors: T
authors: Ueno
authors: Takuya
authors: T
authors: Terai
authors: Hideo
authors: H
authors: Kimura
authors: Tetsuo
authors: T
authors: Nagano
mesh_terms: D003300:Copper / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D006862:Hydrogen Sulfide / Q000032:analysis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; D009942:Organometallic Compounds; D003300:Copper; D006862:Hydrogen Sulfide