title: Cease-fire at the leading edge: new perspectives on actin filament branching, debranching, and cross-linking.
abstract: Membrane protrusion at the leading edge of migrating cells is driven by the polymerization of actin. Recent studies using advanced imaging techniques raised a lively controversy about the morphology of these filaments; however, common ground between the two sides now appears to have been found. Here we discuss how the controversy has led to a deeper consideration of the architecture of actin networks underlying cell migration, and has helped define new challenges that lie ahead.
authors: Department of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts 02454, USA.
authors: Casey A
authors: CA
authors: Ydenberg
authors: Benjamin A
authors: BA
authors: Smith
authors: Dennis
authors: D
authors: Breitsprecher
authors: Jeff
authors: J
authors: Gelles
authors: Bruce L
authors: BL
authors: Goode
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism*; D002465:Cell Movement / Q000502:physiology*; D003599:Cytoskeleton / Q000378:metabolism; D006801:Humans; D008840:Microfilament Proteins / Q000378:metabolism
chemical_list: D008840:Microfilament Proteins