title: Synthesis of novel 3-carboxamide-benzocoumarin derivatives as orally active antithrombotic agents.
abstract: In an effort to develop potent antithrombotic agents, a series of novel 3-carboxamide-benzocoumarin derivatives were synthesized and screened for their in vivo antithrombotic activity. Among 20 compounds tested, the compound 12b showed the most promising antithrombotic activity which was comparable with clinically used aspirin or warfarin, but, at variance with these standard drugs, 12b did not exhibit the increased bleeding time, suggesting its potential as a novel antithrombotic agent.
authors: Medicinal and Process Chemistry Division, Central Drug Research Institute (CDRI-CSIR), Lucknow, India. sashidhar123@gmail.com
authors: Koneni V
authors: KV
authors: Sashidhara
authors: Abdhesh
authors: A
authors: Kumar
authors: Manoj
authors: M
authors: Kumar
authors: S
authors: S
authors: Singh
authors: Manish
authors: M
authors: Jain
authors: Madhu
authors: M
authors: Dikshit
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001241:Aspirin / Q000737:chemistry / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects*; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005343:Fibrinolytic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D014859:Warfarin / Q000737:chemistry / Q000494:pharmacology
chemical_list: C531987:3-carboxy-5,6-benzocoumarinic acid; D003374:Coumarins; D005343:Fibrinolytic Agents; D014859:Warfarin; D001241:Aspirin