title: Interdependence of measures in pavlovian conditioned freezing.
abstract: Pavlovian conditioned freezing is an intensively utilized paradigm that has become a standard model of memory and cognition. Despite its widespread use, the interdependence among each measure commonly reported in fear conditioning studies has not been described. Using mice, we examine the relationship of each common freezing measure (Training Baseline, Post-Shock freezing, Contextual Fear, Tone Baseline, and Tone Fear), as well as baseline locomotor activity measures, to better understand the significance of each. Of particular interest, Post-Shock freezing appears to be a good measure of immediate contextual memory. In contrast, Tone Baseline freezing, as typically measured in a novel context, appears to be contaminated with multiple sources of fear. Finally, Contextual and Tone Fear show a weak interdependence.
authors: The Learning Lab, Department of Psychology, Columbia University, New York, NY 10027, USA. swg2111@columbia.edu
authors: Suzanne C
authors: SC
authors: Wood
authors: Stephan G
authors: SG
authors: Anagnostaras
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D003214:Conditioning, Classical / Q000502:physiology*; D003463:Cues; D004597:Electroshock; D005239:Fear / Q000502:physiology; D005260:Female; D046352:Freezing Reaction, Cataleptic / Q000502:physiology*; D008297:Male; D051379:Mice; D057507:Mice, 129 Strain; D008810:Mice, Inbred C57BL; D011828:Radiation Chimera