title: Radiosurgery for arteriovenous malformations.
abstract: Stereotactic radiosurgery is the term coined by Lars Leksell to describe the application of a single, high dose of radiation to a stereotactically defined target volume. In the 1970s, reports began to appear documenting the successful obliteration of arteriovenous  malformations (AVMs) with radiosurgery. When an AVM is treated with radiosurgery, a pathologic process appears to be induced that is similar to the response-to-injury model of atherosclerosis. Radiation injury to the vascular endothelium is believed to induce the proliferation of smooth-muscle  cells and the elaboration of extracellular collagen, which leads to progressive stenosis and obliteration of the AVM nidus thereby eliminating the risk of hemorrhage. The advantages of radiosurgery - compared to microsurgical and endovascular treatments - are that it is noninvasive,  has minimal risk of acute complications, and is performed as an outpatient procedure requiring no recovery time for the patient. The primary disadvantage of radiosurgery is that cure is not immediate. While thrombosis of the lesion is achieved in the majority of cases, it commonly does not  occur until two or three years after treatment. During the interval between radiosurgical treatment and AVM thrombosis, the risk of hemorrhage remains. Another potential disadvantage of radiosurgery is possible long term adverse effects of radiation. Finally, radiosurgery has been shown to  be less effective for lesions over 10 cc in volume. For these reasons, selection of the optimal treatment for an AVM is a complex decision requiring the input of experts in endovascular, open surgical, and radiosurgical treatment. In the pages below, we will review the world's literature  on radiosurgery for AVMs. Topics reviewed will include the following: radiosurgical technique, radiosurgery results (gamma knife radiosurgery, particle beam radiosurgery, linear accelerator radiosurgery), hemorrhage after radiosurgery, radiation induced complications, repeat radiosurgery,  and radiosurgery for other types of vascular malformation.
authors: Department of Neurological Surgery, University of Florida, Gainesville, FL 32610, USA. friedman@neurosurgery.ufl.edu
authors: William A
authors: WA
authors: Friedman
authors: Frank J
authors: FJ
authors: Bova
mesh_terms: D001165:Arteriovenous Malformations / Q000601:surgery*; D003131:Combined Modality Therapy / Q000379:methods; D006801:Humans; D019106:Postoperative Hemorrhage / Q000453:epidemiology / Q000401:mortality / Q000517:prevention & control; D011832:Radiation Injuries / Q000453:epidemiology / Q000401:mortality; D016634:Radiosurgery / Q000009:adverse effects* / Q000295:instrumentation* / Q000379:methods; D019233:Retreatment / Q000706:statistics & numerical data; D017211:Treatment Failure