title: Granulomas of the penis: a rare complication of intravesical therapy with Bacillus Calmette-Guerin.
abstract: Immunotherapy with Bacillus Calmette-Guérin is widely used for treatment and prophylaxis of superficial urothelial cancer. Complications associated with Bacillus Calmette-Guérin treatment are common. The authors describe a case of granulomatous inflammation of the penis associated with intravesical Bacillus Calmette-Guérin therapy, presenting with multiple erythematous and painless nodules located on the glans. A review of the literature is also performed. Granulomatous balanoposthitis is a rare complication of Bacillus Calmette-Guérin immunotherapy, with heterogeneous clinical presentation, which can make the diagnosis difficult. Its clinical recognition is essential for early start of therapy with antitubercular agents and interruption of Bacillus Calmette-Guérin.
authors: Serviço de Dermatologia, Hospital Santo António dos Capuchos, Lisboa, Portugal. saralestre@gmail.com
authors: Sara Isabel Alcântara
authors: SI
authors: Lestre
authors: Catarina Diogo
authors: CD
authors: Gameiro
authors: Alexandre
authors: A
authors: João
authors: Maria João Paiva
authors: MJ
authors: Lopes
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000009:adverse effects*; D000283:Administration, Intravesical; D000368:Aged; D000995:Antitubercular Agents / Q000627:therapeutic use; D001500:BCG Vaccine / Q000008:administration & dosage / Q000009:adverse effects*; D001446:Balanitis / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D006099:Granuloma / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008297:Male; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy
chemical_list: D000276:Adjuvants, Immunologic; D000995:Antitubercular Agents; D001500:BCG Vaccine