title: [Chemical constitutents from pre-formulation of lonicerae japonicae flos in shuanghuanglian lyophilized powder for injection].
abstract: OBJECTIVE
  To research the chemical constitutents for the pre-formulation of Lonicerae Japonicae Flos (the dried buds of Lonicera japonica) in Shuanghuanglian lyophilized powder for injection and provide substance foundation for the adverse reaction of Shuanghuanglian lyophilized powder for injection.
  
  
  METHODS
  The chemical constituents were isolated by column chromatography and preparative HPLC. All structures were characterized by the spectroscopic methods including ESI-MS, 1H-NMR, 13C-NMR, and compared with data in the literature.
  
  
  RESULTS
  Twenty compounds were isolated and identified as sophoraricoside(1), luteolin-7-O-beta-D-glucopyranoside(2), rutin(3), quercetin(4), 3,5-O-dicaffeoyl quinic acid methyl ester(5), 4,5-O-dicaffeoyl quinic acid methyl ester(6), 3,4-O-dicaffeoyl quinic acid methyl ester(7), 4,5-dicaffeoyl quinic acid(8), 3,4-dicaffeoyl quinic acid(9), chlorogenic acid(10), epi-vogeloside (11), sweroside(12), vogeloside(13), secoxyloganin(14), macranthoidin A(15), macranthoidin B(16), loniceroside A(17), loniceroside B(18), loniceroside C(19), dipsacoside B(20).
  
  
  CONCLUSIONS
  Compound 1 was identified in genus Lonicera for the first time and compounds 1-20 were isolated from the pre-formulation for the first time.
authors: State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. wangnan-2003316@163.com
authors: Nan
authors: N
authors: Wang
authors: Xiuwei
authors: X
authors: Yang
mesh_terms: D002726:Chlorogenic Acid / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D035264:Flowers / Q000737:chemistry*; D005612:Freeze Drying; D031239:Lonicera / Q000737:chemistry*; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000737:chemistry; D011801:Quinic Acid / Q000031:analogs & derivatives / Q000737:chemistry; D012431:Rutin / Q000737:chemistry; D012503:Saponins / Q000737:chemistry
chemical_list: C480201:4,5-dicaffeoyl quinic acid; D004365:Drugs, Chinese Herbal; D012503:Saponins; C533462:loniceroside C; D011801:Quinic Acid; C083463:macranthoidin B; D002726:Chlorogenic Acid; C083461:dipsacoside B; D012431:Rutin; D009828:Oleanolic Acid