title: Mechanisms of glycosyltransferases: the in and the out.
abstract: Getting into a transition state: Glycosyltransferases retain a critical role in glycobiology. The design of potent glycosyltransferase inhibitors may be facilitated by considering the mechanistic evidence presented by Davies and Davis and co-workers that strengthens the case that retaining glycosyltransferases function through a single front-side, S(N)i-type mechanism.
authors: College of Pharmacy and Department of Chemistry, Dalhousie University, Halifax, Nova Scotia, B3H 4R2, Canada.
authors: David L
authors: DL
authors: Jakeman
mesh_terms: D055162:Biocatalysis; D020134:Catalytic Domain; D018360:Crystallography, X-Ray; D005964:Glucosyltransferases / Q000737:chemistry / Q000378:metabolism; D016695:Glycosyltransferases / Q000737:chemistry / Q000378:metabolism*; D007700:Kinetics; D014199:Trehalose / Q000096:biosynthesis
chemical_list: D014199:Trehalose; D016695:Glycosyltransferases; D005964:Glucosyltransferases; C023180:trehalose-6-phosphate synthase