title: Quantitative single-exposure x-ray phase contrast imaging using a single attenuation grid.
abstract: A single-exposure quantitative method of x-ray phase contrast imaging, suitable for animal in vivo observations, is described and shown experimentally both for a known static sample and an ex vivo biological airway. The ability to acquire the desired information within a single exposure is important for dynamic samples, as is sufficient sensitivity to reveal small variations in the composition or thickness of such a sample. This approach satisfies both these needs by analyzing how a reference grid pattern is deformed by the presence of the sample, similar to a Shack-Hartmann sensor. By resolving the shift of the pattern into horizontal and vertical components, a quantitative phase depth map is recovered, sensitive to both sharp edges as well as low phase gradients.
authors: School of Physics, Monash University, Clayton, VIC, 3800, Australia. kaye.morgan@monash.edu
authors: Kaye S
authors: KS
authors: Morgan
authors: David M
authors: DM
authors: Paganin
authors: Karen K W
authors: KK
authors: Siu
mesh_terms: D000042:Absorption; D004058:Diffusion; D005583:Fourier Analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008858:Microscopy, Phase-Contrast / Q000295:instrumentation*; D012542:Scattering, Radiation; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014965:X-Rays