title: Inhibitory effect on NO production of phenolic compounds from Myristica fragrans.
abstract: Three new phenolics: ((7S)-8'-(benzo[3',4']dioxol-1'-yl)-7-hydroxypropyl)benzene-2,4-diol (1), ((7S)-8'-(4'-hydroxy-3'-methoxyphenyl)-7-hydroxypropyl)benzene-2,4-diol (2) and ((8R,8'S)-7-(4-hydroxy-3-methoxyphenyl)-8'-methylbutan-8-yl)-3'-methoxybenzene-4',5'-diol (3), along with four known compounds (4-7) were isolated from the seeds of Myristica fragrans. Their chemical structures were established mainly by 1D and 2D NMR techniques and mass spectrometry. Their anti-inflammatory activity was evaluated against LPS-induced NO production in macrophage RAW264.7 cells.
authors: College of Pharmacy, Catholic University of Daegu, Gyeongbuk 712-702, Republic of Korea.
authors: To Dao
authors: TD
authors: Cuong
authors: Tran Manh
authors: TM
authors: Hung
authors: MinKyun
authors: M
authors: Na
authors: Do Thi
authors: do T
authors: Ha
authors: Jin Cheol
authors: JC
authors: Kim
authors: Dongho
authors: D
authors: Lee
authors: SungWoo
authors: S
authors: Ryoo
authors: Jeong Hyung
authors: JH
authors: Lee
authors: Jae Sue
authors: JS
authors: Choi
authors: Byung Sun
authors: BS
authors: Min
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D026323:Myristica / Q000737:chemistry*; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000276:immunology; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D010636:Phenols; D009569:Nitric Oxide