title: Prenatal management of diaphragmatic rhabdomyosarcoma presenting with fetal hydrops.
abstract: Fetal malignant tumors are rare. We present a case of intrauterine diagnosis of a diaphragmatic tumor presenting with fetal hydrops at 32 weeks' gestation. The sonographic findings were bilateral pleural effusion, ascites and skin edema. A large right-sided diaphragmatic tumor was identified. Owing to the findings on ultrasound and magnetic resonance imaging a solid malignant tumor was suspected. The pleural effusions were drained and malignant cells identified. Because of rapid tumor progression Cesarean section was performed and a hydropic female newborn was delivered at 34 + 0 weeks' gestation. There was no sign of metastatic disease. Postnatally tumor biopsy revealed an alveolar rhabdomyosarcoma. Therapy included chemotherapy and secondary surgical intervention. After a good primary response with complete remission after 6 months, the rhabdomyosarcoma relapsed at 12 months with cerebral metastasis. The prognosis was poor.
authors: Obstetric and Gynaecology Department, University Hospital Frankfurt, Frankfurt, Germany. Anke.Reitter@kgu.de
authors: A
authors: A
authors: Reitter
authors: J
authors: J
authors: Peters
authors: B
authors: B
authors: Wittekindt
authors: H
authors: H
authors: Buxmann
authors: F
authors: F
authors: Geka
authors: U
authors: U
authors: Rolle
authors: R
authors: R
authors: Schlösser
authors: F
authors: F
authors: Louwen
mesh_terms: D000328:Adult; D003964:Diaphragm / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D015160:Hydrops Fetalis / Q000000981:diagnostic imaging* / Q000209:etiology / Q000628:therapy; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D019042:Muscle Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000628:therapy; D011247:Pregnancy; D011296:Prenatal Diagnosis; D011379:Prognosis; D012208:Rhabdomyosarcoma / Q000150:complications / Q000000981:diagnostic imaging* / Q000628:therapy; D014463:Ultrasonography