title: A simple and convenient one-pot synthesis of substituted isoindolin-1-ones via lithiation, substitution and cyclization of N'-benzyl-N,N-dimethylureas.
abstract: Lithiation of N'-benzyl-N,N-dimethylurea and its substituted derivatives with t-BuLi (3.3 equiv) in anhydrous THF at 0 °C followed by reaction with various electrophiles afforded a range of 3-substituted isoindolin-1-ones in high yields.
authors: School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, UK, ; Tel: +44(0)2920870600.
authors: Keith
authors: K
authors: Smith
authors: Gamal A
authors: GA
authors: El-Hiti
authors: Amany S
authors: AS
authors: Hegazy
authors: Benson
authors: B
authors: Kariuki