title: Delivery of sesamol-loaded solid lipid nanoparticles to the brain for menopause-related emotional and cognitive central nervous system derangements.
abstract: The physicochemical nature of sesamol (logP 1.29; solubility 38.8 mg/mL) substantially enhances its tissue distribution, minimizing its brain delivery. Sesamol-loaded solid lipid nanoparticles (S-SLNs) with an average particle size of 122 nm and an entrapment efficiency of 75.9 ± 2.91% were developed. Biochemical and behavioral paradigms clearly established the superiority of orally administered S-SLNs. The same was confirmed evidently by scintigraphic images of rabbits administered radiolabeled SLNs and confocal microscopy of brain sections of rats administered similarly prepared SLNs with a fluorescent marker. This study indicates the special importance of using phosphatidylcholine (as co-surfactant) in the preparation of SLNs for improving memory deficits. The aim of the present work was to develop sesamol as a therapeutic agent for central nervous system derangements.
authors: Department of Pharmaceutics, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
authors: Vandita
authors: V
authors: Kakkar
authors: Anil Kumar
authors: AK
authors: Mishra
authors: Krishna
authors: K
authors: Chuttani
authors: Kanwaljit
authors: K
authors: Chopra
authors: Indu Pal
authors: IP
authors: Kaur
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001522:Behavior, Animal; D052117:Benzodioxoles / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D003071:Cognition / Q000187:drug effects*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D004644:Emotions / Q000187:drug effects*; D005260:Female; D005456:Fluorescent Dyes / Q000494:pharmacology; D005978:Glutathione / Q000378:metabolism; D008593:Menopause / Q000187:drug effects*; D018613:Microscopy, Confocal / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry*; D018384:Oxidative Stress; D010636:Phenols / Q000494:pharmacology*; D010713:Phosphatidylcholines / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility; D013482:Superoxide Dismutase / Q000378:metabolism; D013501:Surface-Active Agents / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D000975:Antioxidants; D052117:Benzodioxoles; D004337:Drug Carriers; D005456:Fluorescent Dyes; D010636:Phenols; D010713:Phosphatidylcholines; D013501:Surface-Active Agents; C025583:sesamol; D013482:Superoxide Dismutase; D005978:Glutathione