title: Koch-Haaf reaction of adamantanols in an acid-tolerant hastelloy-made microreactor.
abstract: The Koch-Haaf reaction of adamantanols was successfully carried out in a microflow system at room temperature. By combining an acid-tolerant hastelloy-made micromixer, a PTFE tube, and a hastelloy-made microextraction unit, a packaged reaction-to-workup system was developed. By means of the present system, the multigram scale synthesis of 1-adamantanecarboxylic acid was achieved in ca. one hour operation.
authors: Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan.
authors: Takahide
authors: T
authors: Fukuyama
authors: Yu
authors: Y
authors: Mukai
authors: Ilhyong
authors: I
authors: Ryu