title: Transient pseudothrombocytopenia in a neonate: transmission of a maternal EDTA-dependent anticoagulant.
abstract: EDTA-dependent pseudothrombocytopenia (PTCP) is characterised by a low platelet count caused by autoantibodies in the serum reacting with EDTA-anticoagulated blood. EDTA-dependent PTCP is caused by a factor that retains EDTA anticoagulation activity in the serum. We report here that a neonate from a mother with PTCP presented with transient low platelet counts when EDTA was used as an anticoagulant. To confirm the transmission of a maternal serum factor to the neonate, we examined to add the maternal serum into the normal blood. Platelet count decreased significantly after adding maternal serum. Clumped platelets were also observed in the smears of mixed samples.
authors: Department of Pediatrics, Hiroshima University Hospital, Minami-ku, Hiroshima, Japan. noriokioono@hiroshima-u.ac.jp
authors: Norioki
authors: N
authors: Ohno
authors: Masao
authors: M
authors: Kobayashi
authors: Seiichi
authors: S
authors: Hayakawa
authors: Akari
authors: A
authors: Utsunomiya
authors: Shuhei
authors: S
authors: Karakawa
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects* / Q000494:pharmacology; D001792:Blood Platelets / Q000378:metabolism / Q000473:pathology; D004492:Edetic Acid / Q000009:adverse effects* / Q000494:pharmacology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D010976:Platelet Count; D011247:Pregnancy; D013921:Thrombocytopenia / Q000097:blood / Q000209:etiology*
chemical_list: D000925:Anticoagulants; D004492:Edetic Acid