Micromanaging the classification of colon cancer: the role of the microRNAome.
Recent advances in our understanding of the microRNAome (miRNAome) have provided further insights into the molecular pathogenesis of colorectal cancer and shown a potential role for miRNAs in distinguishing molecular subtypes. The mucosa-adenoma-carcinoma model can now integrate miRNAs into the known genetic alterations that drive the progression of colorectal neoplasia.
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, USA. evilar@umich.edu
Eduardo
E
Vilar
Josep
J
Tabernero
Stephen B
SB
Gruber
D000230:Adenocarcinoma / Q000235:genetics*; D000236:Adenoma / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics*; D053842:Microsatellite Instability; D018895:Microsatellite Repeats; D040081:Protein Array Analysis
D035683:MicroRNAs