Efficient synthesis of scutellarein.
Scutellarein is a component of Scutellaria, recently known as a potent cytotoxic agent on human leukaemia cells. The aim of this study was the synthesis of scutellarein and its methylated derivative. The new features are the innovating method to afford flavones from flavanones and the A-ring regioselective bromination step that lead to the target molecule by a facile and high-yielding pathway.
C.N.R. Institute of Biomolecular Chemistry (ICB), Unity of Rome, c/o Department of Chemistry, Sapienza University of Rome, p.le A. Moro 5, 00185 Rome, Italy.
Giuliana
G
Righi
Ilaria Proietti
IP
Silvestri
Maurizio
M
Barontini
Fernanda
F
Crisante
Andrea
A
Di Manno
Romina
R
Pelagalli
Paolo
P
Bovicelli
D047310:Apigenin / Q000138:chemical synthesis* / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry; D059808:Polyphenols / Q000737:chemistry; D013237:Stereoisomerism
D005419:Flavonoids; D059808:Polyphenols; D047310:Apigenin; C458179:scutellarein