Behavioral correlates of maternal antibody status among children with autism.
Autism spectrum disorders (ASDs) affect approximately 1 in 110 children in the United States. This report profiles fetal-brain reactive autoantibodies of a large cohort of mothers of children with autism and controls, yielding significant associations between the presence of IgG reactivity to fetal brain proteins at 37 and 73 kDa and a childhood diagnosis of full autism (p = 0.0005), which also correlated with lower expressive language scores (p = 0.005). Additionally, we report on reactivity to proteins at 39 and 73 kDa, which correlated with the broader diagnosis of ASD (p = 0.0007) and increased irritability on the Aberrant Behavioral Checklist (p = 0.05). This study provides evidence of multiple patterns of reactivity to fetal brain proteins by maternal antibodies associated with ASD and specific childhood behavioral outcomes.
Division of Rheumatology/Allergy and Clinical Immunology, University of California, Davis, 451 E Health Sciences Drive, Suite 6510 GBSF, Davis, CA 95616, USA.
Daniel
D
Braunschweig
Paul
P
Duncanson
Robert
R
Boyce
Robin
R
Hansen
Paul
P
Ashwood
Isaac N
IN
Pessah
Irva
I
Hertz-Picciotto
Judy
J
Van de Water
D000818:Animals; D000918:Antibody Specificity / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000097:blood; D015153:Blotting, Western; D001921:Brain / Q000196:embryology* / Q000276:immunology*; D002653:Child Behavior Disorders / Q000175:diagnosis / Q000276:immunology* / Q000523:psychology*; D002659:Child Development Disorders, Pervasive / Q000175:diagnosis / Q000276:immunology* / Q000523:psychology*; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007805:Language Development Disorders / Q000175:diagnosis / Q000276:immunology / Q000523:psychology; D008253:Macaca mulatta; D008297:Male; D009035:Mothers; D011247:Pregnancy; D012016:Reference Values; D013045:Species Specificity
D001323:Autoantibodies; D001324:Autoantigens; D007074:Immunoglobulin G