Individual variations in arsenic metabolism in Vietnamese: the association with arsenic exposure and GSTP1 genetic polymorphism.
We investigated the association of As exposure and genetic polymorphism in glutathione S-transferase π1 (GSTP1) with As metabolism in 190 local residents from the As contaminated groundwater areas in the Red River Delta, Vietnam. Total As concentrations in groundwater ranged from <0.1 to 502 μg l(-1). Concentrations of dimethylarsinic acid (DMA(V)), monomethylarsonic acid (MMA(V)), and arsenite (As(III)) in human urine were positively correlated with total As levels in the groundwater, suggesting that people in these areas may be exposed to As through the groundwater. The concentration ratios of urinary As(III)/arsenate (As(V)) and MMA(V)/inorganic As (IA; As(III) + As(V))(M/I), which are indicators of As metabolism, increased with the urinary As level. Concentration and proportion of As(III) were high in the wild type of GSTP1 Ile105Val compared with the hetero type, and these trends were more pronounced in the higher As exposure group (>56 μg l(-1) creatinine in urine), but not in the lower exposure group. In the high As exposure group, As(III)/As(V) ratios in the urine of wild type of GSTP1 Ile105Val were significantly higher than those of the hetero type, while the opposite trend was observed for M/I. These results suggest that the excretion and metabolism of IA may depend on both the As exposure level and the GSTP1 Ile105Val genotype.
Center for Marine Environmental Studies (CMES), Ehime University, Matsuyama 790-8577, Japan.
Tetsuro
T
Agusa
Takashi
T
Kunito
Nguyen Minh
NM
Tue
Vi Thi Mai
VT
Lan
Junko
J
Fujihara
Haruo
H
Takeshita
Tu Binh
TB
Minh
Pham Thi Kim
PT
Trang
Shin
S
Takahashi
Pham Hung
PH
Viet
Shinsuke
S
Tanabe
Hisato
H
Iwata
D000293:Adolescent; D000328:Adult; D000368:Aged; D001151:Arsenic / Q000737:chemistry / Q000378:metabolism* / Q000652:urine; D044466:Asian People / Q000235:genetics*; D002648:Child; D005260:Female; D005838:Genotype; D051549:Glutathione S-Transferase pi / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D014744:Vietnam; D014874:Water Pollutants, Chemical / Q000737:chemistry / Q000378:metabolism*; D014881:Water Supply; D055815:Young Adult
D014874:Water Pollutants, Chemical; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi; D001151:Arsenic