Predicted 25-hydroxyvitamin D score and change in fasting plasma glucose in the Framingham offspring study.
Data on the association between vitamin D status and actual change in glycemic measures are limited. We examined the prospective association between a predicted 25-hydroxyvitamin D (25(OH)D) score and change in fasting plasma glucose concentration over a mean follow-up of 7 years, in 2571 men and women (mean age 54 years) without diabetes in the Framingham Offspring Study cohort. After adjustment for age, sex, body mass index and fasting plasma glucose at baseline, higher predicted 25(OH)D score at baseline was associated with a smaller 7-year increase in fasting plasma glucose concentrations (0.23 mmol/l versus 0.35 mmol/l for highest versus lowest tertile of 25(OH)D score, respectively, P-trend=0.002). Vitamin D status may be an important determinant for change in fasting plasma glucose concentration among middle-aged and older adults without diabetes.
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA. eliu@hsph.harvard.edu
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E
Liu
N M
NM
McKeown
A G
AG
Pittas
J B
JB
Meigs
C D
CD
Economos
S L
SL
Booth
P F
PF
Jacques
D001786:Blood Glucose / Q000378:metabolism*; D005215:Fasting; D005260:Female; D005500:Follow-Up Studies; D006304:Health Status; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
D001786:Blood Glucose; D014807:Vitamin D; C104450:25-hydroxyvitamin D