Tailor-made peptide synthetases.
Harnessing the modular architecture of non-ribosomal peptide synthetases for combinatorial biosynthesis is a longstanding goal in chemical biology. Several recent reports illustrate how computational design and directed evolution can be used to tailor the specificity of these assembly-line enzymes.
Laboratory of Organic Chemistry, ETH Zürich, CH-8093 Zurich, Switzerland.
Hajo
H
Kries
Donald
D
Hilvert