Discovery of α,β- and α,γ-diamino acid scaffolds for the inhibition of M1 family aminopeptidases.
Center for Chemical Biology, Indian Institute of Chemical Technology, Tarnaka, Hyderabad, AP-500 607, India.
Rajesh
R
Gumpena
Chandan
C
Kishor
Roopa Jones
RJ
Ganji
Anthony
A
Addlagatta
D000599:Amino Acids, Diamino / Q000737:chemistry* / Q000494:pharmacology; D000613:Aminobutyrates / Q000737:chemistry; D000626:Aminopeptidases / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D001665:Binding Sites; D020134:Catalytic Domain; D018360:Crystallography, X-Ray; D015195:Drug Design; D006801:Humans; D008715:Methionine; D008958:Models, Molecular; D011480:Protease Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D012694:Serine / Q000737:chemistry; D015091:beta-Alanine / Q000494:pharmacology
D000599:Amino Acids, Diamino; D000613:Aminobutyrates; D001426:Bacterial Proteins; D011480:Protease Inhibitors; D015091:beta-Alanine; C075633:pepN protein, Bacteria; C005959:2,4-diaminobutyric acid; D012694:Serine; D008715:Methionine; C522314:2,3-diaminobutanoic acid; D000626:Aminopeptidases; C025579:enkephalin degrading enzyme