The role of PAI-1 and adiponectin on the inflammatory state and energy balance in obese adolescents with metabolic syndrome.
Obesity is a chronic inflammatory disease and is considered a risk factor for metabolic syndrome. In this study, 57 obese adolescents with and without metabolic syndrome underwent 1 year of weight loss therapy. At baseline, the metabolic syndrome (MS) patients presented higher values of PAI-1 than the non-metabolic syndrome patients (n-MS). After therapy, significant improvements in anthropometrics and biochemical, inflammatory, and neuroendocrine variables were observed in both groups. However, the n-MS group presented better results than the MS group. Indeed, we found positive correlations in both groups between PAI-1 and neuropeptide Y (NPY) and between PAI-1 and NPY/AgRP. Inflammatory biomarkers may thus play a role in energy balance. The clinical trial registration number is NCT01358773.
Post-Graduation Program of Nutrition, Paulista Medicine School, Universidade Federal de São Paulo, Rua Franscisco de Castro 93, São Paulo, 04020-050, Brazil. flaviacorgosinho@hotmail.com
Flavia Campos
FC
Corgosinho
Aline
A
de Piano
Priscila L
PL
Sanches
Raquel M
RM
Campos
Patricia L
PL
Silva
June
J
Carnier
Lila M
LM
Oyama
Lian
L
Tock
Sergio
S
Tufik
Marco T
MT
de Mello
Ana R
AR
Dâmaso
D052242:Adiponectin / Q000097:blood* / Q000378:metabolism; D050154:Adiposity; D000293:Adolescent; D054369:Agouti-Related Protein / Q000378:metabolism; D001823:Body Composition; D015992:Body Mass Index; D004734:Energy Metabolism; D015444:Exercise; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism / Q000628:therapy*; D009478:Neuropeptide Y / Q000378:metabolism; D009765:Obesity / Q000378:metabolism / Q000628:therapy*; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood* / Q000378:metabolism; D061217:Weight Reduction Programs; D055815:Young Adult
C515198:AGRP protein, human; D052242:Adiponectin; D054369:Agouti-Related Protein; D009478:Neuropeptide Y; D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human