Quick and highly efficient copper-catalyzed cycloaddition of organic azides with terminal alkynes.
Good to excellent yields of 1,4-disubstituted 1,2,3-triazoles were obtained within 2-25 min when the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction was carried out under solvent-free conditions, with [Cu(phen)(PPh(3))(2)]NO(3) (1mol%) as the catalyst.
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, PR of China.
Dong
D
Wang
Mingming
M
Zhao
Xiang
X
Liu
Yongxin
Y
Chen
Na
N
Li
Baohua
B
Chen
D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
D000480:Alkynes; D001386:Azides; D009942:Organometallic Compounds; D014230:Triazoles; D003300:Copper