The expression profile of Fc receptor-like Y in B lymphocytes with hepatitis B virus induced diseases.
The Fc Receptor-like Y (FcRY) molecule is preferentially expressed by B lymphocytes and has recently been considered as a potential therapeutic target for B cell malignancies. In this study, we investigated the correlation between FcRY expression profile, B lymphocytes population and different HBV infection disease status. The FcRY expression level on B lymphocytes and the number of B lymphocytes population from peripheral blood in 27 healthy controls (HC) and 65 patients with HBV-induced diseases, including chronic hepatitis B (CHB), liver cirrhosis (LC) and hepatocellular carcinoma (HCC), were analyzed using quantitative real-time PCR and flow cytometry. The results showed the level of FcRY expression and frequency of germinal center (GC) B lymphocytes from peripheral blood were significantly correlated with the HBV-related disease status, which was highest in HCC and LC patients, lowest in healthy donors, and in the middle in patients with CHB. Our study indicates that there is a significant correlation between FcRY expression profile, B lymphocytes population and HBV-induced diseases. However, the roles of FcRY and B lymphocytes in HBV-induced diseases are unclear and need further investigation.
Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, Jiangsu Province, China.
Ke
K
Wang
Run-Lin
RL
Yang
Hao
H
Pei
Hang-Yuan
HY
Wu
Jue
J
Zhang
Biao
B
Huang
D000328:Adult; D001402:B-Lymphocytes / Q000378:metabolism* / Q000502:physiology / Q000821:virology*; D005260:Female; D020869:Gene Expression Profiling; D006509:Hepatitis B / Q000378:metabolism* / Q000503:physiopathology; D006515:Hepatitis B virus / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000378:metabolism; D011961:Receptors, Fc / Q000235:genetics / Q000378:metabolism*
D012333:RNA, Messenger; D011961:Receptors, Fc