Evaluation of myocardial viability with cardiac magnetic resonance imaging.
Assessment of myocardial viability is of clinical and scientific significance. Traditionally, the detection of myocardial viability (either stunning or hibernation) has been used in aiding diagnosis before revascularization, especially in high-risk patients. There is a considerable body of observational evidence showing substantial improvement after revascularization in patients with significant left ventricular dysfunction and myocardial viability. Recent randomized evidence has questioned the benefit of viability testing but must be interpreted with caution. Dobutamine stress echocardiography, nuclear imaging, and cardiovascular magnetic resonance are the mainstays of viability testing and provide information on contractile function, cellular metabolism, and myocardial fibrosis, respectively. Larger, multicenter trials with outcome data are needed to define the nature of viability testing and, particularly, cardiovascular magnetic resonance in moderate-to-severe ischemic cardiomyopathy.
Department of Cardiovascular Medicine, Flinders Medical Centre, Australia.
Suchi
S
Grover
Govindarajan
G
Srinivasan
Joseph B
JB
Selvanayagam
D009202:Cardiomyopathies / Q000175:diagnosis / Q000473:pathology; D006331:Heart Diseases / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D017682:Myocardial Stunning / Q000175:diagnosis / Q000473:pathology; D009206:Myocardium / Q000473:pathology*; D011237:Predictive Value of Tests; D011379:Prognosis; D012720:Severity of Illness Index; D014022:Tissue Survival; D016277:Ventricular Function, Left