[Advances in functional studies of nonstructural proteins and development of antiviral agents for enterovirus 71].
Human enterovirus 71 (EV71) is one of the major etiological agents for the hand, foot, and month disease (HFMD) and is causing frequent, widespread occurrence in the mainland of China. The single positive-stranded RNA genome of EV71 is translated into a single polyprotein which is autocleavaged into structural and nonstructural proteins. The functions of many nonstructural proteins characterized in the life cycle of virus are potential targets for blocking viral replication. This article reviews the studies of the structures and functions of nonstructural proteins of EV71 and the anti-enterovirus 71 drugs targeting on these nonstructural proteins.
College of Life Science, Qufu Normal University, Qufu 273165, China.
Xian-Yun
XY
Qin
Lin
L
Lin
Yan
Y
Yang
Shu-Xiang
SX
Zhang
Jian-Qiang
JQ
Kong
Ke-Di
KD
Cheng
Yun-Feng
YF
Zhao
Wei
W
Wang
D000998:Antiviral Agents / Q000494:pharmacology*; D029821:Enterovirus A, Human / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D006232:Hand, Foot and Mouth Disease / Q000188:drug therapy / Q000821:virology*; D006801:Humans; D058990:Molecular Targeted Therapy; D010447:Peptide Hydrolases / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D012367:RNA, Viral / Q000235:genetics; D017361:Viral Nonstructural Proteins / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D047428:Protein Kinase Inhibitors; D012367:RNA, Viral; D017361:Viral Nonstructural Proteins; D010447:Peptide Hydrolases