Coexistence of autoimmune polyglandular syndrome type 2 and diabetes insipidus in pregnancy.
Autoimmune polyglandular syndromes are rarely diagnosed conditions characterized by the association of at least 2 organ-specific autoimmune disorders. Very few cases of these syndromes have been described during pregnancy. The authors report a case of a patient diagnosed with autoimmune thyroiditis and a history of HELLP (hemolysis, elevated liver enzymes and low platelet) syndrome in a prior pregnancy. After increasing the levothyroxine dose, she developed Addisonian crisis. Normalization of adrenal cortex function resulted in the appearance of diabetes insipidus. This report shows that pregnancy may influence the course of preexisting endocrine disorders and lead to their unmasking. Although the risk of the development of autoimmune polyglandular syndromes during pregnancy is small, they may pose a serious health problem. The possible presence of these clinical entities should be considered in every woman with 1 or more endocrine disturbances.
Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland. r.krysiak@interia.pl
Robert
R
Krysiak
Malgorzata
M
Samborek
D000224:Addison Disease / Q000139:chemically induced; D000328:Adult; D003919:Diabetes Insipidus / Q000453:epidemiology* / Q000276:immunology; D005260:Female; D006801:Humans; D016884:Polyendocrinopathies, Autoimmune / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy / Q000276:immunology*; D013974:Thyroxine / Q000627:therapeutic use
D013974:Thyroxine