Protective effects of passively transferred merozoite-specific antibodies against Theileria equi in horses with severe combined immunodeficiency.
Theileria equi immune plasma was infused into young horses (foals) with severe combined immunodeficiency. Although all foals became infected following intravenous challenge with homologous T. equi merozoite stabilate, delayed time to peak parasitemia occurred. Protective effects were associated with a predominance of passively transferred merozoite-specific IgG3.
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA. rhm@vetmed.wsu.edu
Robert H
RH
Mealey
Lowell S
LS
Kappmeyer
Massaro W
MW
Ueti
Bettina
B
Wagner
Donald P
DP
Knowles
D000818:Animals; D000913:Antibodies, Protozoan / Q000008:administration & dosage* / Q000276:immunology; D006734:Horse Diseases / Q000517:prevention & control* / Q000628:therapy; D006736:Horses; D007116:Immunization, Passive / Q000379:methods*; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000276:immunology; D007155:Immunologic Factors / Q000008:administration & dosage* / Q000276:immunology; D052940:Merozoites / Q000276:immunology; D018512:Parasitemia / Q000517:prevention & control; D016511:Severe Combined Immunodeficiency / Q000662:veterinary*; D016794:Theileria / Q000276:immunology; D013801:Theileriasis / Q000517:prevention & control*; D013997:Time Factors
D000913:Antibodies, Protozoan; D007074:Immunoglobulin G; D007155:Immunologic Factors