Decrease in rate of myopia progression with a contact lens designed to reduce relative peripheral hyperopia: one-year results.
OBJECTIVE
To determine whether a novel optical treatment using contact lenses to reduce relative peripheral hyperopia can slow the rate of progress of myopia.


METHODS
Chinese children, aged 7 to 14 years, with baseline myopia from sphere -0.75 to -3.50 D and cylinder ≤1.00 D, were fitted with novel contact lenses (n = 45) and followed up for 12 months, and their progress was compared with that of a group (n = 40) matched for age, sex, refractive error, axial length, and parental myopia wearing normal, single-vision, spherocylindrical spectacles.


RESULTS
On adjusting for parental myopia, sex, age, baseline spherical equivalent (SphE) values, and compliance, the estimated progression in SphE at 12 months was 34% less, at -0.57 D, with the novel contact lenses (95% confidence interval [CI], -0.45 -0.69 D) than at -0.86 D, with spectacle lenses (95% CI, -0.74 to -0.99 D). For an average baseline age of 11.2 years, baseline SphE of -2.10 D, a baseline axial length of 24.6 mm, and 320 days of compliant lens wear, the estimated increase in axial length (AL) was 33% less at 0.27 mm (95% CI, 0.22-0.32 mm) than at 0.40 mm (95% CI, 0.35-0.45 mm) for the contact lens and spectacle lens groups, respectively.


CONCLUSIONS
The 12-month data support the hypothesis that reducing peripheral hyperopia can alter central refractive development and reduce the rate of progress of myopia. (chictr.org number, chiCTR-TRC-00000029 or chiCTR-TRC-00000032.).
Brien Holden Vision Institute, Sydney, Australia.
Padmaja
P
Sankaridurg
Brien
B
Holden
Earl
E
Smith
Thomas
T
Naduvilath
Xiang
X
Chen
Percy Lazon
PL
de la Jara
Aldo
A
Martinez
Judy
J
Kwan
Arthur
A
Ho
Kevin
K
Frick
Jian
J
Ge
D000293:Adolescent; D002648:Child; D003261:Contact Lenses; D018450:Disease Progression; D004867:Equipment Design; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006956:Hyperopia / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D009216:Myopia / Q000503:physiopathology / Q000628:therapy*; D011446:Prospective Studies; D012029:Refraction, Ocular; D013997:Time Factors; D016896:Treatment Outcome