Biological evaluation of glucose and deoxyglucose derivatives radiolabeled with [99mTc(CO)3(H2O)3]+ core as potential melanoma imaging agents.
Glucose 9 and 2-deoxyglucose 10 were successfully synthesized and radiolabeled with [(99m)Tc(CO)(3)(H(2)0)(3)](+) intermediate in high yield. The complexes were characterized by HPLC and its stability with histidine over time was challenged. Cell uptake and biodistribution studies in melanoma-bearing C57BL/6 mice were performed. Both compounds showed accumulation in tumor tissue with high tumor-to-muscle ratios. Thus, D-glucose- and D-2-deoxyglucose-(99m)Tc complex could be considered as agents for melanoma diagnosis.
Laboratorio de Química Orgánica, Igua 4225, Facultad de Ciencias-Facultad de Química, Universidad de la República, Montevideo, Uruguay.
Rosina
R
Dapueto
Romina
R
Castelli
Marcelo
M
Fernández
José A
JA
Chabalgoity
María
M
Moreno
Juan Pablo
JP
Gambini
Pablo
P
Cabral
Williams
W
Porcal
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003847:Deoxyglucose / Q000737:chemistry / Q000493:pharmacokinetics; D004355:Drug Stability; D005947:Glucose / Q000737:chemistry / Q000493:pharmacokinetics; D008545:Melanoma / Q000175:diagnosis*; D051379:Mice; D008810:Mice, Inbred C57BL; D015394:Molecular Structure; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D014018:Tissue Distribution
D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D003847:Deoxyglucose; D005947:Glucose