Polymorphisms of the SLC11A1 gene and resistance to bovine tuberculosis in African Zebu cattle.
Bovine tuberculosis (BTB) is a considerable health threat to livestock keepers and general communities in many developing countries. Information on genetic resistance or susceptibility because of polymorphisms of candidate genes could be used in making selection decisions for breeding disease tolerant/resistant animals. Here, we investigated associations between polymorphisms at the solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 gene (SLC11A1, previously known as natural resistant associated macrophage protein 1, NRAMP1), with BTB phenotypes in Chadian cattle. Phenotypes were (i) single intradermal comparative cervical tuberculin test (SICCT) outcome, (ii) presence of gross visible lung lesions, (iii) a bacteriological culture test outcome and (iv) a predicted true BTB infection status using a Bayesian model. All traits were recorded as binary (presence or absence) traits. A total of 211 cattle were genotyped for a microsatellite within the SLC11A1 candidate gene. Standard linear and threshold-liability models regressing BTB traits on copy number of SLC11A1 alleles revealed statistically significant effects of SLC11A1 alleles (P < 0.001) on most BTB traits. Polymorphisms (alleles 211, 215 and 217) are significantly related to lower incidence of BTB traits in Chadian cattle. This is the first study to report the association of SLC11A1 gene polymorphisms with BTB traits in Chadian or any other African cattle breeds.
Division of Genetics and Bioinformatics, Department of Animal and Veterinary Basic Sciences, Faculty of Life Sciences, University of Copenhagen, Groennegaardsvej 3, Frederiksberg, Copenhagen, Denmark. hajak@life.ku.dk
H N
HN
Kadarmideen
A A
AA
Ali
P C
PC
Thomson
B
B
Müller
J
J
Zinsstag
D000818:Animals; D027682:Cation Transport Proteins / Q000235:genetics*; D002417:Cattle; D005260:Female; D008168:Lung / Q000473:pathology; D008297:Male; D009163:Mycobacterium bovis; D011110:Polymorphism, Genetic; D014380:Tuberculosis, Bovine / Q000235:genetics* / Q000276:immunology* / Q000473:pathology; D000099173:Natural Resistance-associated Macrophage Protein 1
D027682:Cation Transport Proteins; D000099173:Natural Resistance-associated Macrophage Protein 1