Clonal production and organization of inhibitory interneurons in the neocortex.
The neocortex contains excitatory neurons and inhibitory interneurons. Clones of neocortical excitatory neurons originating from the same progenitor cell are spatially organized and contribute to the formation of functional microcircuits. In contrast, relatively little is known about the production and organization of neocortical inhibitory interneurons. We found that neocortical inhibitory interneurons were produced as spatially organized clonal units in the developing ventral telencephalon. Furthermore, clonally related interneurons did not randomly disperse but formed spatially isolated clusters in the neocortex. Individual clonal clusters consisting of interneurons expressing the same or distinct neurochemical markers exhibited clear vertical or horizontal organization. These results suggest that the lineage relationship plays a pivotal role in the organization of inhibitory interneurons in the neocortex.
Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Keith N
KN
Brown
She
S
Chen
Zhi
Z
Han
Chun-Hui
CH
Lu
Xin
X
Tan
Xin-Jun
XJ
Zhang
Liya
L
Ding
Alejandro
A
Lopez-Cruz
Dieter
D
Saur
Stewart A
SA
Anderson
Kun
K
Huang
Song-Hai
SH
Shi
D000818:Animals; D019070:Cell Lineage; D002465:Cell Movement; D002999:Clone Cells / Q000166:cytology / Q000502:physiology; D055879:Gene Knock-In Techniques; D007395:Interneurons / Q000166:cytology* / Q000502:physiology*; D051379:Mice; D008938:Mitosis; D019579:Neocortex / Q000166:cytology* / Q000196:embryology; D009433:Neural Inhibition; D058953:Neural Stem Cells / Q000166:cytology* / Q000502:physiology; D055495:Neurogenesis; D009457:Neuroglia / Q000166:cytology / Q000502:physiology; D011301:Preoptic Area / Q000166:cytology / Q000196:embryology; D013687:Telencephalon / Q000166:cytology* / Q000196:embryology