Biology-driven library design for probe discovery.
Libraries of diverse small molecules are important to probe and drug discovery. The current trend toward building massive screening collections to support drug development, a special application of chemical biology, can limit their broader potential. Biology-driven construction methods (Wallace et al., 2011) are rapidly emerging to bring chemical libraries back on a viable path.
NIH Center for Translational Therapeutics, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA. jinglese@mail.nih.gov
James
J
Inglese
Samuel A
SA
Hasson