An electrochemical procedure to concentrate 99mTc availed from a zirconium [99Mo] molybdate gel generator.
Successful use of electrochemical method to concentrate (99m)Tc obtained from a zirconium molybdate (Zr(99)Mo) gel generator is reported. The process consists of electrodeposition of the (99m)Tc in an oxalate bath on a small platinum electrode followed by recovery of (99m)Tc in a small volume of normal saline. The overall recovery of (99m)Tc was >90% with >99.99% radionuclidic purity and >99% radiochemical purity. The compatibility of the product in the preparation of (99m)Tc labeled formulations such as (99m)Tc-DMSA and (99m)Tc-EC was found to be satisfactory in terms of high labeling yields (>98%).
Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India.
Rubel
R
Chakravarty
S K
SK
Sarkar
Meera
M
Venkatesh
Ashutosh
A
Dash
D004595:Electroplating / Q000379:methods; D005782:Gels; D008982:Molybdenum / Q000528:radiation effects*; D011868:Radioisotopes / Q000302:isolation & purification*; D019275:Radiopharmaceuticals / Q000302:isolation & purification*; D013667:Technetium / Q000302:isolation & purification*; D015040:Zirconium / Q000528:radiation effects*
D005782:Gels; D011868:Radioisotopes; D019275:Radiopharmaceuticals; C052112:zirconium molybdate; D013667:Technetium; D008982:Molybdenum; D015040:Zirconium