Primary adenocarcinoma of the stomach in von Recklinghausen's disease with high serum levels of multiple tumor markers: a case report.
BACKGROUND
Gastric tumors in patients affected by neurofibromatosis type 1 are usually carcinoids or stromal tumors, and rarely adenocarcinomas.


METHODS
We report a case of an adenocarcinoma of the stomach in a 53-year-old Japanese man with neurofibromatosis type 1. An abdominal computed tomography scan and ultrasonography showed tumors in his liver. Gastric fibroscopy revealed a Borrmann type III tumor on his cardia that had spread to his esophagus and was highly suspicious for malignancy. Multiple biopsies showed an adenocarcinoma of the stomach, which was evaluated as gastric cancer, stage IV. Chemotherapy with TS-1 was performed. Our patient died four weeks after initial admission. Histological examination of a liver needle biopsy showed metastatic adenocarcinoma in his liver.


CONCLUSIONS
To the best of our knowledge, high serum levels of α-fetoprotein, carcinoembryonic antigen, and carbohydrate antigen 72-4, resulting from gastric adenocarcinoma, have not been reported previously in a patient with neurofibromatosis type 1. We report this rare case along with a review of the literature.
Department of Surgery, Pippu Clinic, 2-10, 1 Cyome Nakamachi, Pippu Town Kamikawa-gun, Hokkaido, 078-0343, Japan. pippuclinickato@gold.ocn.ne.jp.
Kazuya
K
Kato
Atsushi
A
Nagase
Kazuhiko
K
Onodera
Minoru
M
Matsuda
Yoshiaki
Y
Iwasaki
Yurina
Y
Kato
Kimitaka
K
Kato
Takako
T
Kawakami
Masahiko
M
Taniguchi
Hiroyuki
H
Furukawa