The hsa-miR-5739 modulates the endoglin network in endothelial cells derived from human embryonic stem cells.
MicroRNAs are small, noncoding RNAs that bind to seed sequences on the 3' untranslated regions of their target genes and then negatively regulate gene expressions via the RISC complex. The novel miRNA, hsa-miR-5739, was cloned and characterized its function and cellular expression in current study. The hsa-miR-5739 downregulated endothelial cells that were derived from human ES cells significantly suppressed the translational level of endoglin. This study showed that characterized hsa-miR-5739 expression by performing expression during endothelial differentiation and demonstrate potential roles of hsa-miR-5739 in human endothelial cell differentiation.
Department of Pharmacy, College of Pharmacy, CHA University, 222 Yatap-dong, Bundang-gu, Seongnam-si, Gyeonggi-do 463-836, Republic of Korea.
Jung Ki
JK
Yoo
Jumi
J
Kim
Seong-Jun
SJ
Choi
Chang-Hyun
CH
Kim
Dong Ryul
DR
Lee
Hyung Min
HM
Chung
Jin Kyeoung
JK
Kim
D015703:Antigens, CD / Q000096:biosynthesis* / Q000235:genetics; D002454:Cell Differentiation; D003001:Cloning, Molecular; D053595:Embryonic Stem Cells / Q000166:cytology* / Q000378:metabolism; D000071063:Endoglin; D042783:Endothelial Cells / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000502:physiology*; D014176:Protein Biosynthesis; D011956:Receptors, Cell Surface / Q000096:biosynthesis* / Q000235:genetics
D015703:Antigens, CD; C064206:ENG protein, human; D000071063:Endoglin; C569330:MIRN5739 microRNA, human; D035683:MicroRNAs; D011956:Receptors, Cell Surface