Synthesis and characterization of a template-assembled synthetic U-quartet.
A lipophilic cavitand containing four triazole-linked uridine residues has been synthesized and characterized. Spectral evidence suggests a quartet arrangement of the uracil residues at both ambient and low temperatures. Treatment of the compound with Sr(2+) yields a homodimeric complex as evidenced by NMR spectroscopy.
Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, Canada BC V6T 1Z1.
Benjamin Wei-Qiang
BW
Hui
John C
JC
Sherman
D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D004988:Ethers, Cyclic / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D009682:Magnetic Resonance Spectroscopy; D009690:Nucleic Acid Conformation; D012118:Resorcinols / Q000737:chemistry; D014529:Uridine / Q000737:chemistry*
D004988:Ethers, Cyclic; D012118:Resorcinols; C442939:cavitand; D014529:Uridine