Nanocarrier possibilities for functional targeting of bioactive peptides and proteins: state-of-the-art.
This review attempts to provide an updated compilation of studies reported in the literature pertaining to production of nanocarriers encasing peptides and/or proteins, in a way that helps the reader direct a bibliographic search and develop an integrated perspective of the subject. Highlights are given to bioactive proteins and peptides, with a special focus on those from dairy sources (including physicochemical characteristics and properties, and biopharmaceutical application possibilities of e.g. lactoferrin and glycomacropeptide), as well as to nanocarrier functional targeting. Features associated with micro- and (multiple) nanoemulsions, micellar systems, liposomes and solid lipid nanoparticles, together with biopharmaceutical considerations, are presented in the text in a systematic fashion.
Bioengineering and Biopharmaceutical Chemistry Research Group, Faculty of Health Sciences, Fernando Pessoa University, Porto, Portugal.
Carla G
CG
Moutinho
Carla M
CM
Matos
José A
JA
Teixeira
Victor M
VM
Balcão
D000818:Animals; D003611:Dairy Products; D004333:Drug Administration Routes; D004337:Drug Carriers / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry* / Q000627:therapeutic use*; D016503:Drug Delivery Systems / Q000379:methods*; D004655:Emulsions / Q000008:administration & dosage / Q000737:chemistry; D006801:Humans; D008081:Liposomes / Q000008:administration & dosage / Q000737:chemistry; D008823:Micelles; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry; D010455:Peptides / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D011506:Proteins / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*
D004337:Drug Carriers; D004655:Emulsions; D008081:Liposomes; D008823:Micelles; D010455:Peptides; D011506:Proteins