Antimicrobial activity of an Amazon medicinal plant (Chancapiedra) (Phyllanthus niruri L.) against Helicobacter pylori and lactic acid bacteria.
The potential of water extracts of the Amazon medicinal plant Chancapiedra (Phyllanthus niruri L.) from Ecuador and Peru for antimicrobial activity against Helicobacter pylori and different strains of lactic acid bacteria such as Lactobacillus acidophilus, Lactobacillus casei and Lactobacillus plantarum was investigated. H. pylori was inhibited by both water extracts in a dose dependent manner, whereas lactic acid bacterial growth was not affected. Both extracts contained ellagic acid and hydroxycinnamic acid derivatives and exhibited high free radical scavenging linked-antioxidant activities (89%). However, gallic acid was detected only in the Ecuadorian extract. Preliminary studies on the mode of action of Chancapiedra against H. pylori revealed that inhibition may not involve proline dehydrogenase-based oxidative phosphorylation inhibition associated with simple mono-phenolics and could involve ellagitannins or other non-phenolic compounds through a yet unknown mechanism. This study provides evidence about the potential of Chancapiedra for H. pylori inhibition without affecting beneficial lactic acid bacteria.
Escuela de Alimentos, Facultad de Recursos Naturales, Pontificia Universidad Católica de Valparaíso, Avenida Waddington 716, Playa Ancha, Valparaíso, Chile.
Lena Gálvez
LG
Ranilla
Emmanouil
E
Apostolidis
Kalidas
K
Shetty
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry; D003373:Coumaric Acids / Q000737:chemistry / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004484:Ecuador; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000254:growth & development; D047348:Hydrolyzable Tannins / Q000737:chemistry / Q000494:pharmacology; D007778:Lactobacillus / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D010085:Oxidative Phosphorylation; D010568:Peru; D029803:Phyllanthus / Q000737:chemistry*; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D011394:Proline Oxidase / Q000737:chemistry; D014867:Water / Q000737:chemistry
D000900:Anti-Bacterial Agents; D001713:Biphenyl Compounds; D003373:Coumaric Acids; D016166:Free Radical Scavengers; D047348:Hydrolyzable Tannins; D010851:Picrates; D010936:Plant Extracts; D014867:Water; C004931:1,1-diphenyl-2-picrylhydrazyl; D011394:Proline Oxidase