Open-angle glaucoma and the risk of erectile dysfunction: a population-based case-control study.
OBJECTIVE
Open-angle glaucoma (OAG) is associated with systemic metabolic and cardiovascular disorders, and both share common risk factors with erectile dysfunction (ED). However, few studies have investigated the association of ED with OAG. This study aimed to estimate the association of ED with prior OAG by using a nationwide, population-based data with a retrospective case-control cohort design in Taiwan.


METHODS
Age-matched case-control study.


METHODS
We identified 4605 patients with ED as the cases and randomly selected 23 025 subjects as the controls (5 controls to 1 case).


METHODS
We used conditional logistic regression analysis to estimate the odds ratio and 95% confidence interval of having previously been diagnosed with OAG according to the presence/absence of ED after adjusting for patient's monthly income, geographical location, hypertension, diabetes, coronary heart disease, hyperlipidemia, obesity, and alcohol abuse.


METHODS
We identified OAG cases not only based on an International Classification of Diseases, Ninth Revision, Clinical Modification code, but also by the prescription of topical antiglaucoma medication.


RESULTS
In total, prior OAG was found among 137 subjects (0.5 %); 53 individuals (1.1% of the ED patients) from the cases and 84 individuals (0.4% of patients without ED) from the controls. Conditional logistic regression analysis demonstrated that, after adjusting for potential confounders, patients with ED were more likely to have prior OAG than controls (odds ratio, 2.85; 95% confidence interval, 2.10-4.07).


CONCLUSIONS
This study identifies a novel association between ED and prior OAG.
Division of Urology, Department of Surgery, Far Eastern Memorial Hospital, Ban Ciao, Taipei, Taiwan.
Shiu-Dong
SD
Chung
Chao-Chien
CC
Hu
Jau-Der
JD
Ho
Joseph J
JJ
Keller
Tsung-Jen
TJ
Wang
Herng-Ching
HC
Lin
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D007172:Erectile Dysfunction / Q000453:epidemiology*; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012189:Retrospective Studies; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology
D000959:Antihypertensive Agents