Insecticidal activity of isobutylamides derived from Piper nigrum against adult of two mosquito species, Culex pipiens pallens and Aedes aegypti.
The insecticidal activity of Piper nigrum fruit-derived piperidine alkaloid (piperine) and N-isobutylamide alkaloids (pellitorine, guineensine, pipercide and retrofractamide A) against female adults of Culex pipiens pallens and Aedes aegypti was examined. On the basis of 24-h LD(50) values, the compound most toxic to female C. pipiens pallens was pellitorine (0.4 µg/♀) followed by guineensine (1.9 µg/♀), retrofractamide A (2.4 µg/♀) and pipercide (3.2 µg/♀). LD(50) value of chlorpyrifos was 0.03 µg/♀. Against female A. aegypti, the insecticidal activity was more pronounced in pellitorine (0.17 µg/♀) than in retrofractamide A (1.5 µg/♀), guineensine (1.7 µg/♀), and pipercide (2.0 µg/♀). LD(50) value of chlorpyrifos was 0.0014 µg/♀.
Division of Forest Insect Pests and Diseases, Korea Forest Research Institute, Republic of Korea. parkik1@forest.go.kr
Il-Kwon
IK
Park
D000330:Aedes / Q000187:drug effects*; D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D000475:Alkenes / Q000737:chemistry / Q000494:pharmacology; D000577:Amides / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D052117:Benzodioxoles / Q000737:chemistry / Q000494:pharmacology; D003465:Culex / Q000187:drug effects*; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D006574:Heterocyclic Compounds, 2-Ring / Q000737:chemistry / Q000494:pharmacology; D007306:Insecticides / Q000737:chemistry* / Q000494:pharmacology*; D008297:Male; D029222:Piper nigrum / Q000737:chemistry*; D010880:Piperidines / Q000737:chemistry / Q000494:pharmacology; D053284:Polyunsaturated Alkamides / Q000737:chemistry / Q000494:pharmacology
D000470:Alkaloids; D000475:Alkenes; D000577:Amides; D052117:Benzodioxoles; D005231:Fatty Acids, Unsaturated; D006574:Heterocyclic Compounds, 2-Ring; D007306:Insecticides; D010880:Piperidines; D053284:Polyunsaturated Alkamides; C492480:guineensine; C454279:retrofractamide A; C008778:pellitorine; C008922:piperine