Neither proteinuria nor albuminuria is associated with endothelial dysfunction in HIV-infected patients without diabetes or hypertension.
It is unknown whether systemic endothelial dysfunction underlies the association between nephropathy and cardiovascular disease (CVD) in persons infected with human immunodeficiency virus (HIV). Spot urine protein to creatinine ratio, spot urine albumin to creatinine ratio, creatinine clearance, estimated glomerular filtration rate, and flow-mediated dilation (FMD) of the brachial artery were evaluated in 123 study participants infected with HIV (58 receiving antiretroviral therapy [ART] and 65 not receiving ART) with no history of diabetes or hypertension. None of the renal markers, modeled as either continuous or categorical variables, correlated with FMD. Contrary to expectations, endothelial dysfunction may not be the link between nephropathy and CVD in HIV.
Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA. sgupta1@iupui.edu
Samir K
SK
Gupta
Changyu
C
Shen
Kieren J
KJ
Mather
Rajiv
R
Agarwal
Michael P
MP
Dubé
D000225:Adenine / Q000031:analogs & derivatives / Q000494:pharmacology; D000328:Adult; D000419:Albuminuria / Q000652:urine*; D000480:Alkynes; D019380:Anti-HIV Agents / Q000494:pharmacology; D048588:Benzoxazines / Q000494:pharmacology; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology*; D016009:Chi-Square Distribution; D003404:Creatinine / Q000097:blood / Q000652:urine; D003521:Cyclopropanes; D015224:Dideoxynucleosides / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D015658:HIV Infections / Q000188:drug therapy / Q000503:physiopathology* / Q000652:urine*; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D063065:Organophosphonates / Q000494:pharmacology; D011507:Proteinuria / Q000652:urine; D000068698:Tenofovir; D014463:Ultrasonography; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*; D000099227:Abacavir
D000225:Adenine; D000480:Alkynes; D019380:Anti-HIV Agents; D048588:Benzoxazines; D003404:Creatinine; D003521:Cyclopropanes; D015224:Dideoxynucleosides; D063065:Organophosphonates; D000068698:Tenofovir; D000099227:Abacavir; C098320:efavirenz