[Increased risk of cancer in the urinary tract in patients with hereditary colorectal cancer].
During screening of 20 selected patients with hereditary non-polyposis colorectal cancer (HNPCC) (Lynch syndrome) carried out in the Department of Urology of Odense University Hospital from 2001 to 2010, two patients without urologic symptoms with cancer in the ureter were found. The purpose of the present case report is to underline the importance of referring those patients with HNPCC that have increased risk of urologic cancer to screening of the urinary tract. Furthermore, this paper seeks to point out the necessity of further investigation in the risk of urologic cancer in the different mutations causing HNPCC, as well as the effects of the different screening methods in order to find the optimal screening population and the optimal screening method.
Urologisk Afdeling L, Odense Universitetshospital, Denmark. peter_zachhau@hotmail.com
Peter
P
Zachhau
Steen
S
Walter
D000328:Adult; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000150:complications* / Q000235:genetics; D005260:Female; D005820:Genetic Testing; D006801:Humans; D008403:Mass Screening; D008875:Middle Aged; D051718:MutS Homolog 2 Protein / Q000235:genetics; D009154:Mutation; D012307:Risk Factors; D014516:Ureteral Neoplasms / Q000209:etiology* / Q000235:genetics
C497172:MSH2 protein, human; D051718:MutS Homolog 2 Protein