Isolated subcutaneous metastasis of osteosarcoma 5 years after initial diagnosis.
The pediatric malignancies most likely to metastasize to the skin are neuroblastoma, leukemia, and rhabdomyosarcoma. Cutaneous and subcutaneous metastases from osteosarcoma are extremely rare, with only a few cases reported in pediatric patients with multifocal synchronous osteosarcoma. We describe the case of a 19-year-old woman with a single subcutaneous nodule of the abdominal wall that, on histologic evaluation, proved to be a metastatic high-grade osteosarcoma 5 years after her initial diagnosis.
Department of Surgery, St Jude Children's Research Hospital, Memphis, TN 38105-3678, USA. israel.fernandez@stjude.org
Israel
I
Fernandez-Pineda
Armita
A
Bahrami
James F
JF
Green
Lisa M
LM
McGregor
Andrew M
AM
Davidoff
John A
JA
Sandoval
D034861:Abdominal Wall; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000209:etiology; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008175:Lung Neoplasms / Q000556:secondary / Q000601:surgery; D008727:Methotrexate / Q000008:administration & dosage; D020360:Neoadjuvant Therapy; D059351:Organ Sparing Treatments; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D011859:Radiography; D011929:Razoxane / Q000008:administration & dosage; D017526:Receptor, IGF Type 1 / Q000276:immunology; D012878:Skin Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary* / Q000601:surgery; D040521:Subcutaneous Tissue; D013977:Tibia / Q000473:pathology* / Q000601:surgery; D013997:Time Factors; D055815:Young Adult
D000911:Antibodies, Monoclonal; D011929:Razoxane; D004317:Doxorubicin; D017526:Receptor, IGF Type 1; D002945:Cisplatin; D007069:Ifosfamide; D008727:Methotrexate