Risk factors associated with hepatitis C virus infection in an urban population of the State of Mexico.
The aim of this study was to determine the seroprevalence anti-hepatitis C virus (HCV) antibodies and risk factors associated with patients attending primary-care clinics in the State of Mexico. A cross-sectional, prospective study was conducted on 10,524 consenting patients with history of at least one risk factor for HCV. Antibodies were detected by immunoassay, third-generation ELISA; RT-PCR was carried out to confirm HCV infection. The seroprevalence of HCV antibodies was 1.2% (128). The most common risk factor was blood transfusion prior to 1993 (56.3%), followed by family history of cirrhosis 29 (22.7%); tattoos and/or piercings, 28 (21.9%); high-risk sexual practices, 4 (3.1%); healthcare work, 8 (6.3%); and intravenous drug use, 1 (8%). RT-PCR was performed on samples from 83 patients. Forty-five were considered positive. Genotype 1a was the most prevalent (37.7%).
Health Research Coordination Office, Mexico Western Regional Office, Mexican Institute of Social Security, Josefa Ortiz de Domínguez S/N Col. San Sebastián, CP 5000 Toluca, Mexico, México. maria.romerof@imss.gob.mx
S
S
Romero-Figueroa
E
E
Ceballos-Salgado
L
L
Santillán-Arreygue
M
M
Miranda-García
M
M
Rubio-Lezama
J J
JJ
Garduño-García
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D016174:Hepacivirus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification* / Q000502:physiology; D006508:Hepatitis Antibodies / Q000276:immunology; D006526:Hepatitis C / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D014505:Urban Population / Q000706:statistics & numerical data*; D055815:Young Adult
D006508:Hepatitis Antibodies