Deletion of the tumor-suppressor gene NF1 occurs in 5% of myeloid malignancies and is accompanied by a mutation in the remaining allele in half of the cases.
C
C
Haferlach
V
V
Grossmann
A
A
Kohlmann
S
S
Schindela
W
W
Kern
S
S
Schnittger
T
T
Haferlach
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics; D005260:Female; D017353:Gene Deletion; D016147:Genes, Tumor Suppressor; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D025542:Neurofibromin 1 / Q000235:genetics* / Q000502:physiology
D050676:Core Binding Factor Alpha 2 Subunit; D025542:Neurofibromin 1; C493728:RUNX1 protein, human