Improving sensitivity of EEG-fMRI studies in epilepsy: the role of sleep-specific activity.
Using simultaneous recordings of EEG and functional MRI (EEG-fMRI) in patients with focal epilepsy, recent studies have revealed insufficient sensitivity and a lack of correspondence between epileptic EEG foci and activation patterns in some patients. In this study of children with focal epilepsy, we explore whether sleep-specific activity (sleep spindles, k-complexes and vertex sharp waves) may increase the sensitivity of EEG-fMRI of interictal epileptiform discharges (IED). When considering the sleep-specific activity in a statistical model, it was possible to increase the statistical significance of the activated voxels inside of the expected source of the IED and to reduce the number of activated voxels outside of it. According to this study, it could be worthwhile to include sleep-specific activity into the model by analyzing EEG-fMRI data in epilepsy.
Department of Neuropediatrics, Christian-Albrechts-University, Kiel, Germany. jan.moehring@uk-sh.de
Jan
J
Moehring
Diana
D
Coropceanu
Andreas
A
Galka
Friederike
F
Moeller
Stephan
S
Wolff
Rainer
R
Boor
Olav
O
Jansen
Ulrich
U
Stephani
Michael
M
Siniatchkin
D000513:Alpha Rhythm / Q000502:physiology; D001931:Brain Mapping / Q000379:methods; D058256:Brain Waves / Q000502:physiology; D002540:Cerebral Cortex / Q000502:physiology / Q000503:physiopathology; D002648:Child; D004569:Electroencephalography / Q000379:methods*; D004827:Epilepsy / Q000175:diagnosis* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D012890:Sleep / Q000502:physiology; D012894:Sleep Stages / Q000502:physiology; D012893:Sleep Wake Disorders / Q000175:diagnosis* / Q000503:physiopathology*