Impact of vitamin D receptor gene polymorphisms on clinical outcomes of HLA-matched sibling hematopoietic stem cell transplantation.
We hypothesized that polymorphisms of the vitamin D receptor (VDR) gene might affect clinical outcomes of allogeneic hematopoietic stem cell transplantation (HSCT). Three VDR gene polymorphisms (BsmI G>A, ApaI G>T, and TaqI T>C) were genotyped in 147 patients who underwent HLA-matched sibling allogeneic HSCT. Frequencies of infection, graft-vs.-host disease (GVHD), overall survival (OS), and disease-free survival (DFS) were compared according to genotypes and haplotypes. Infection and acute GVHD had trends to be less frequent in patients with ApaI TT genotype than non-TT genotypes (p = 0.061 and p = 0.059, respectively). For TaqI genotypes, there were no statistical differences in frequency of infection and acute GVHD (p = 0.84 and p = 0.30, respectively), but TC genotype was associated with longer OS and DFS than TT genotype (p = 0.022 and p = 0.038, respectively). In the ApaI-TaqI haplotype analysis, patients with TC haplotype had significantly longer OS and DFS than those without TC haplotype (p = 0.022 and p = 0.038, respectively). In multivariable analysis, TaqI genotype and ApaI-TaqI haplotype of recipients were independent prognostic factors for both OS and DFS. This study suggests that the genotype and haplotype of VDR in recipient might be associated with clinical outcome of sibling HLA-matched HSCT.
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Hyeon Jin
HJ
Cho
Dong-Yeop
DY
Shin
Jin Hee
JH
Kim
Ji-Yeon
JY
Bae
Kyung-Hun
KH
Lee
Cha Ja
CJ
See
Naeyu
N
Kim
Eun Kyung
EK
Park
Eun Kyung
EK
Ra
Jong-Eun
JE
Lee
Yun-Chul
YC
Hong
Hyun Kyung
HK
Kim
Sung Sup
SS
Park
Sung-Soo
SS
Yoon
Dong Soon
DS
Lee
Kyou-Sup
KS
Han
Myoung Hee
MH
Park
Seonyang
S
Park
Byoung Kook
BK
Kim
Inho
I
Kim
D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006086:Graft vs Host Disease / Q000209:etiology / Q000401:mortality*; D006680:HLA Antigens / Q000276:immunology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006648:Histocompatibility; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D018167:Receptors, Calcitriol / Q000235:genetics*; D035781:Siblings; D015996:Survival Rate; D055815:Young Adult
D006680:HLA Antigens; D018167:Receptors, Calcitriol