Synthesis of functionalized 2,3-dihydroisoxazoles by domino reactions in water and unexpected ring-opening reactions of 2,3-dihydroisoxazoles.
α,α-Dicyanoolefins react with hydroxylamine to afford 2,3-dihydroisoxazoles (2,3-dihydroisoxazoles can be easily isolated by filtration) in excellent yields under mild and environmentally benign conditions. A one-pot reaction in tandem with an unexpected ring-opening of 2,3-dihydroisoxazoles has been developed as well.
Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Department of Chemistry and Life Science, Zhejiang Normal University, 321004 Jinhua, China.
Ping
P
Li
Bo-Tao
BT
Teng
Fa-Gen
FG
Jin
Xin-Sheng
XS
Li
Wei-Dong
WD
Zhu
Jian-Wu
JW
Xie
D020106:Acrylamide / Q000138:chemical synthesis* / Q000737:chemistry; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D014867:Water / Q000737:chemistry*
D007555:Isoxazoles; D014867:Water; D020106:Acrylamide