Small molecules from spiders used as chemical probes.
Spiders are important species in ecological systems and as major predators of insects they are endowed with a plethora of low-molecular-weight natural products having intriguing biological activities. The isolation and biological characterization of these entities are well established, however, only very recently have these compounds been used as templates for the design, synthesis, and biological evaluation of synthetic analogues. In contrast, the investigation of compounds responsible for chemical communication between spiders is far less developed, but recently new light has been shed onto the area of pheromones and allomones from spiders. Herein, we recapitulate these recent results, put them into perspective with previous findings, and provide an outlook for future studies of these chemotypes.
Department of Chemistry, Technical University of Denmark, Kgs. Lyngby, Denmark.
Christian A
CA
Olsen
Anders S
AS
Kristensen
Kristian
K
Strømgaard
D000818:Animals; D010675:Pheromones / Q000737:chemistry; D011073:Polyamines / Q000737:chemistry; D013112:Spiders / Q000737:chemistry*; D014118:Toxins, Biological / Q000737:chemistry
D010675:Pheromones; D011073:Polyamines; D014118:Toxins, Biological