Acute lung injury: prevention may be the best medicine.
Acute lung injury affects a subset of hospitalized patients but is not universal. This syndrome can substantially delay ventilator liberation, prolong intensive care unit (ICU) stay, and increase mortality. As with many critical illness syndromes, the available treatment options are  limited in number and impact. Once a patient develops lung injury, the best known strategy is supportive care. Observational studies have identified potential risk factors and have suggested that the use and timing of certain critical care interventions may influence the likelihood of developing  lung injury. These findings suggest that a well designed screening tool and the systematic application of best practices in critical care may limit the risk of lung injury. An effective prediction score may also facilitate enrollment in pharmacopreventive trials. Development of such tools  is accelerated by multicenter collaboration.
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA. litell.john@mayo.edu
John M
JM
Litell
Michelle Ng
MN
Gong
Daniel
D
Talmor
Ognjen
O
Gajic
D055371:Acute Lung Injury / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D001803:Blood Transfusion; D015984:Causality; D002986:Clinical Trials as Topic; D016638:Critical Illness; D006801:Humans; D018570:Risk Assessment