Transplacental transfer of medetomidine and ketamine in pregnant ewes.
The extent of placental transfer of medetomidine and ketamine is unknown in pregnant ewes. Date-mated singleton (n = 8) and twin (n = 8) pregnant merino cross ewes were anaesthetized for Caesarean delivery of preterm lamb fetuses. A combination of medetomidine (20 μg/kg) and ketamine (10 mg/kg) was administered by intravenous injection and surgery performed immediately thereafter. Blood samples were collected from the ewe at one, five and 10 min after intravenous injection and from the umbilical vein of the fetus at delivery. Non-pregnant ewes were also anaesthetized (n = 8). There was no difference in the plasma concentration of medetomidine or ketamine when comparing singleton and twin ewes or pregnant and non-pregnant ewes for the short duration of the study. Fetal plasma concentrations of each drug were comparable to the maternal concentrations at the same time. We conclude that both drugs cross the placenta readily and provide anaesthesia and analgesia for the fetus when it is delivered.
School of Veterinary and Biomedical Sciences, Murdoch University, Western Australia 6150, Australia. g.musk@murdoch.edu.au
G C
GC
Musk
J D
JD
Netto
G L
GL
Maker
R D
RD
Trengove
D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000778:Anesthetics, Dissociative / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D002585:Cesarean Section; D002853:Chromatography, Liquid; D004338:Drug Combinations; D005260:Female; D007275:Injections, Intravenous; D007649:Ketamine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008431:Maternal-Fetal Exchange; D020926:Medetomidine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D010920:Placenta / Q000737:chemistry; D011247:Pregnancy; D012756:Sheep; D052616:Solid Phase Extraction; D053719:Tandem Mass Spectrometry
D018712:Analgesics, Non-Narcotic; D000778:Anesthetics, Dissociative; D004338:Drug Combinations; D007649:Ketamine; D020926:Medetomidine