Electrochemical signal modulation in homogeneous solutions using the formation of an inclusion complex between ferrocene and β-cyclodextrin on a DNA scaffold.
Two DNA conjugates modified with ferrocene and β-cyclodextrin were prepared as a pair of probes that work cooperatively for DNA sensing, in which the electrochemical signal of ferrocene on one probe was significantly "quenched" by the formation of an inclusion complex with β-cyclodextrin of the other probe on the DNA templates.
Department of Applied Chemistry and Biochemistry, Kumamoto University, Kumamoto 860-8555, Japan. toshi@chem.kumamoto-u.ac.jp
Toshihiro
T
Ihara
Tsugutoshi
T
Wasano
Ryuta
R
Nakatake
Pelin
P
Arslan
Akika
A
Futamura
Akinori
A
Jyo
D055664:Electrochemical Techniques; D005296:Ferrous Compounds / Q000737:chemistry*; D000075163:Metallocenes; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D010084:Oxidation-Reduction; D044366:Transition Temperature; D047392:beta-Cyclodextrins / Q000737:chemistry*
D005296:Ferrous Compounds; D000075163:Metallocenes; D009838:Oligodeoxyribonucleotides; D047392:beta-Cyclodextrins; C031215:betadex; C004998:ferrocene