[Lack of effect of substitution therapy of alpha1-antitrypsin deficiency].
Persons with alpha1-antitrypsin (A1AT) deficiency and chronic obstructive pulmonary disease (COPD) have been tested for the clinical value of regular intravenous infusion with A1AT in two small double-blind randomised controlled trials. The trials found a statistical significant reduction in the decrease of lung density measured by computed tomographies, but found no clinical nor statistical significant difference in respiratory symptoms, quality of life, lung function, use of medication, exacerbations, respiratory infections or survival. Based on the present evidence A1AT substitution therapy cannot be recommended.
Lungemedicinsk Afdeling B, Aarhus Universitetshospital, Nørrebrogade 44, 8000 Aarhus C, Denmark.
Ronald
R
Dahl
Ole
O
Hilberg
Anders
A
Løkke
Lars
L
Pedersen
Thomas
T
Ringbæk
Ingrid
I
Titlestad
D019317:Evidence-Based Medicine; D006801:Humans; D007262:Infusions, Intravenous; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy* / Q000209:etiology; D011656:Pulmonary Emphysema / Q000000981:diagnostic imaging / Q000209:etiology; D011859:Radiography; D016896:Treatment Outcome; D000515:alpha 1-Antitrypsin / Q000008:administration & dosage / Q000627:therapeutic use*; D019896:alpha 1-Antitrypsin Deficiency / Q000150:complications / Q000188:drug therapy*
D000515:alpha 1-Antitrypsin