Association of TNFSF8 polymorphisms with peripheral neutrophil count.
OBJECTIVE
To investigate the association between 347 single-nucleotide polymorphisms within candidate genes of the tumor necrosis factor, interleukin 1 and interleukin 6 families with neutrophil count.


METHODS
Four hundred cases with heart failure after myocardial infarction (MI) were matched by age, sex, and date of incident MI to 694 controls (MI without post-MI heart failure). Both genotypes and neutrophil count at admission for incident MI were available in 314 cases and 515 controls.


RESULTS
We found significant associations between the TNFSF8 poly morphisms rs927374 (P=5.1 x 10(-5)) and rs2295800 (P=1.3 x 10(-4)) and neutrophil count; these single-nucleotide polymorphisms are in high linkage disequilibrium (r(2)=0.97). Associations persisted after controlling for clinical characteristics and were unchanged after adjusting for case-control status. For rs927374, the neutrophil count of GG homozygotes (7.6±5.1) was 16% lower than that of CC homozygotes (9.0±5.2).


CONCLUSIONS
The TNFSF8 polymorphisms rs927374 and rs2295800 were associated with neutrophil count. This finding suggests that post-MI inflammatory response is genetically modulated.
Division of Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
Adelaide M
AM
Arruda-Olson
Véronique L
VL
Roger
High S
HS
Chai
Mariza
M
de Andrade
Brooke L
BL
Fridley
Julie M
JM
Cunningham
Sherine E
SE
Gabriel
Suzette J
SJ
Bielinski
D000368:Aged; D000369:Aged, 80 and over; D053285:CD30 Ligand / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics; D015850:Interleukin-6 / Q000235:genetics; D007958:Leukocyte Count; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction; D020641:Polymorphism, Single Nucleotide; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D053285:CD30 Ligand; D007375:Interleukin-1; D015850:Interleukin-6; C505774:TNFSF8 protein, human; D014409:Tumor Necrosis Factor-alpha