The immunomodulatory effects of Ipomoea carnea in rats vary depending on life stage.
Ipomoea carnea Jacq. ssp. fistulosa (Mart. Ex Choisy; Convolvulaceae; I. carnea) possesses a toxic component: an indolizidine alkaloid swainsonine (SW) that has immunomodulatory effects due to its inhibition of glycoprotein metabolism. It is also known that SW is excreted into both the amniotic fluid and milk of female rats exposed to I. carnea. Thus, the aim of this study was to determine whether SW exposure, either in utero or from the milk of dams treated with I. carnea, modulates offspring immune function into adulthood. In addition, adult (70 days old) and juvenile rats (21 days old) were exposed to I. carnea in order to evaluate several other immune parameters: lymphoid organs relative weight and cellularity, humoral and cellular immune responses. Offspring exposed to I. carnea during lactation developed rheumatoid arthritis (RA) in adulthood after an immunogenic challenge. In addition, both adult and juvenile rats exposed to I. carnea showed discrepancies in several immune parameters, but did not exhibit any decrease in humoral immune response, which was enhanced at both ages. These findings indicate that SW modulates immune function in adult rats exposed to SW during lactation and in juvenile and adult rats exposed to SW as juveniles and adults, respectively.
1Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo (UNIFESP), Diadema, S.P., Brazil.
Isis M
IM
Hueza
Silvana L
SL
Górniak
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000139:chemically induced / Q000276:immunology; D001854:Bone Marrow Cells / Q000187:drug effects / Q000473:pathology; D005260:Female; D033023:Foot Joints / Q000473:pathology; D006099:Granuloma / Q000139:chemically induced / Q000473:pathology; D006968:Hypersensitivity, Delayed / Q000139:chemically induced / Q000276:immunology; D056724:Immunity, Humoral / Q000187:drug effects; D007155:Immunologic Factors / Q000633:toxicity*; D027741:Ipomoea / Q000737:chemistry*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007774:Lactation / Q000276:immunology*; D008262:Macrophage Activation / Q000187:drug effects; D008297:Male; D010936:Plant Extracts / Q000633:toxicity; D018515:Plant Leaves / Q000737:chemistry; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D017026:Swainsonine / Q000633:toxicity*; D013950:Thymus Gland / Q000187:drug effects / Q000254:growth & development
D007155:Immunologic Factors; D010936:Plant Extracts; D017026:Swainsonine