Optimal sedative dose of propofol to start MRI in children with cerebral palsy.
BACKGROUND
This study was designed to determine the optimal sedative dose of propofol to start brain magnetic resonance imaging (MRI) in children with cerebral palsy (CP).


METHODS
Twenty children, aged 0.5-5 years, were administered propofol to achieve a University of Michigan Sedation Scale (UMSS) score ≥ 3 in the MRI room. The proper dose of propofol was determined using the up-and-down method.


RESULTS
The ED50 and ED95 for successful sedation with a UMSS ≥ 3 were 2.07 mg/kg (95% CI 1.69-2.56) and 2.69 mg/kg (95% CI 2.35-5.59). Respiratory events occurred in 5 patients and were resolved with neck extension, chin lift, or transient respiratory assistance with successful sedation.


CONCLUSIONS
Low dose propofol can safely facilitate the initiation of MRI in children with CP.
Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea.
Eun Jung
EJ
Kim
Youn Yi
YY
Jo
Hae Keum
HK
Kil