Comparative pharmacokinetics of three triterpene acids in rat plasma after oral administration of Poria extract and its formulated herbal preparation: GuiZhi-FuLing capsule.
A sensitive liquid chromatographic-mass spectrometric technique coupled with liquid-liquid extraction method was developed and validated for simultaneous determination of dehydro-tumulosic acid, tumulosic acid and polyporic acid C in rat plasma. The analytes were separated on a Kromasil C(18) column with a total running time of 12.5 min. Author had compared the pharmacokinetics of dehydro-tumulosic acid, tumulosic acid and polyporic acid C after oral administration of the extract of Poria and its formulated herbal preparation (GuiZhi-FuLing capsule). The improved pharmacokinetic profiles of the three compounds were found in the GuiZhi-FuLing capsule, indicating the more effective absorption and the slower elimination, compared with the Poria extract. Furthermore, this study revealed that as far as the Poria extract was concerned, it is very valuable to be used as a clinical instruction of GF capsule.
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Feng
F
Xiao
Qing
Q
Li
Ke
K
Liang
Longshan
L
Zhao
Bosai
B
He
Wei
W
Ji
Xiaohui
X
Chen
Zhengzhong
Z
Wang
Kaishun
K
Bi
Ying
Y
Jia
D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D002853:Chromatography, Liquid; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics*; D005260:Female; D006207:Half-Life; D013058:Mass Spectrometry; D015394:Molecular Structure; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics*; D055441:Poria / Q000737:chemistry*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012680:Sensitivity and Specificity; D013047:Specific Pathogen-Free Organisms; D014315:Triterpenes / Q000737:chemistry*
D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D014315:Triterpenes