Mapuche herbal medicine inhibits blood platelet aggregation.
12 plant species traditionally used by the Mapuche people in Chile to treat wounds and inflammations have been evaluated for their direct blood platelet inhibition. Seven of the 12 tested plant species showed platelet inhibitory effect in sheep blood, and four of these were also able to inhibit the ADP- (5.0 μM) and collagen- (2.0 μg/mL) induced aggregations in human blood. These four species in respective extracts (in brackets) were Blechnum chilense (MeOH), Luma apiculata (H(2)O), Amomyrtus luma (DCM : MeOH 1 : 1) and Cestrum parqui (DCM : MeOH 1 : 1). The platelet aggregating inhibitory effects of A. luma (DCM : MeOH 1 : 1), and L. apiculata (H(2)O) were substantial and confirmed by inhibition of platelet surface activation markers.
Department of Plant Biology and Biotechnology, VKR Research Centre Pro-Active Plants, Faculty of Life Sciences, University of Copenhagen, 1871 Copenhagen, Denmark.
Susan Skanderup
SS
Falkenberg
Inge
I
Tarnow
Alfonso
A
Guzman
Per
P
Mølgaard
Henrik Toft
HT
Simonsen