Antitumour and antioxidant activity of Scutia myrtina against Ehrlich ascites carcinoma in Swiss albino mice.
The aim of this study is to investigate the antitumour and antioxidant activities of the ethanol extract of Scutia myrtina (EESM) against Ehrlich's ascites carcinoma (EAC) in mice. Twenty-four hours after tumour inoculation, EESM was administered at doses 100, 200 and 300 mg kg⁻¹ bodyweight/mice/day for 21 days. EESM caused a significant (p < 0.01) decrease in ascites volume, packed cell volume and viable cell count, and also prolonged the life span of EAC tumour-bearing mice. Haematological profiles reverted to near-normal levels in extract-treated mice (p < 0.01). EESM also produced protective effects by significantly decreasing the activity of serum enzymes and bilirubin and increasing the protein and uric acid levels (p < 0.05). EESM significantly (p < 0.05) decreased the levels of lipid peroxidation, while it significantly (p < 0.05) increased the levels of enzymatic and non-enzymatic antioxidants. The results indicate that EESM exhibited significant antitumour and antioxidant activities in EAC-bearing mice.
Department of Pharmaceutics and Pharmacology, Faculty of Pharmacy, 7th of April University, Al-Zawia, Libya. sambathju2002@yahoo.co.in
Ramanathan Sambath
RS
Kumar
Kupusamy Asok
KA
Kumar
Nallasamy Venkateswara
NV
Murthy
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D045744:Cell Line, Tumor; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D027823:Rhamnaceae / Q000737:chemistry*; D023041:Xenograft Model Antitumor Assays
D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants