Schistosoma comparative genomics: integrating genome structure, parasite biology and anthelmintic discovery.
Schistosoma genomes provide a comprehensive resource for identifying the molecular processes that shape parasite evolution and for discovering novel chemotherapeutic or immunoprophylactic targets. Here, we demonstrate how intragenus and intergenus comparative genomics can be used to drive these investigations forward, illustrate the advantages and limitations of these approaches and review how post-genomic technologies offer complementary strategies for genome characterisation. Although sequencing and functional characterisation of other schistosome/platyhelminth genomes continues to expedite anthelmintic discovery, we contend that future priorities should equally focus on improving assembly quality, and chromosomal assignment, of existing schistosome/platyhelminth genomes.
Institute of Biological, Environmental and Rural Sciences, Aberystwyth University, Aberystwyth, UK.
Martin T
MT
Swain
Denis M
DM
Larkin
Conor R
CR
Caffrey
Stephen J
SJ
Davies
Alex
A
Loukas
Patrick J
PJ
Skelly
Karl F
KF
Hoffmann
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology; D002875:Chromosomes; D049751:Genome, Helminth / Q000235:genetics*; D023281:Genomics / Q000379:methods*; D006801:Humans; D012547:Schistosoma / Q000187:drug effects / Q000235:genetics* / Q000502:physiology; D012552:Schistosomiasis / Q000469:parasitology* / Q000628:therapy
D000871:Anthelmintics