Association of the ADRA1A gene and the severity of metabolic abnormalities in patients with schizophrenia.
Patients with schizophrenia have a higher risk of developing metabolic abnormalities and their associated diseases. Some studies found that the accumulative number of metabolic syndrome components was associated with the severity of metabolic abnormalities. The purpose of this study was to examine the roles of the ADRA1A, ADRA2A, ADRB3, and 5HT2A genes in the risk of having more severe metabolic abnormalities among patients with schizophrenia. We studied a sample of 232 chronic inpatients with schizophrenia (120 males and 112 females) to explore the associations between the four candidate genes and the severity of metabolic syndrome by accumulative number of the components. Four single nucleotide polymorphisms in the candidate genes were genotyped, including the Arg347Cys in ADRA1A, the C1291G in ADRA2A, the Try64Arg in ADRB3, and the T102C in 5HT2A. An association between the accumulative number of metabolic syndrome components and the ADRA1A gene was found after adjusting age, sex, and other related variables (p-value=0.036). Presence of the Arg347 allele in the ADRA1A gene is a risk factor for having more severe metabolic abnormalities. These findings suggest a medical attention of closely monitoring metabolic risks for schizophrenia patients with high-risk genotypes.
Department of Psychiatry, Taichung Veterans General Hospital, No. 200, Ln. 164, Sec. 3, Chung-Kang Rd., Taichung City 407, Taiwan. ccchinnn@gmail.com
Chin
C
Cheng
Hsien-Jane
HJ
Chiu
El-Wui
el-W
Loh
Chin-Hong
CH
Chan
Tzong-Ming
TM
Hwu
Yun-Ru
YR
Liu
Tsuo-Hung
TH
Lan
D000328:Adult; D001120:Arginine / Q000235:genetics; D003545:Cysteine / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies / Q000379:methods; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D018340:Receptors, Adrenergic, alpha-1 / Q000235:genetics*; D012307:Risk Factors; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D012720:Severity of Illness Index
C547713:ADRA1A protein, human; D018340:Receptors, Adrenergic, alpha-1; D001120:Arginine; D003545:Cysteine