Oral administration of insulin-like growth factor-I from colostral whey reduces blood glucose in streptozotocin-induced diabetic mice.
The aim of the present study was to investigate the effects of oral administration of the insulin-like growth factor-I-rich fraction (IGF-I-RF) from bovine colostral whey on the regulation of blood glucose levels in streptozotocin (STZ)-induced diabetic mice. We obtained a peptide fraction containing IGF-I (10 ng/mg protein) from Holstein colostrum within 24 h after parturition by using ultrafiltration. The blood glucose levels of STZ-induced diabetic mice fed with IGF-I-RF (50 μg/kg per d) were significantly reduced by 11 and 33 % at weeks 2 and 4, respectively (P < 0·05). The body weights of STZ-induced diabetic mice increased following the oral administration of the IGF-I-RF. The kidney weights of STZ-induced diabetic mice decreased significantly (P < 0·05) following the administration of the IGF-I-RF, and the liver weights of STZ-induced diabetic mice decreased significantly (P < 0·05) following the administration of 50 μg/kg per d of the IGF-I-RF. The present results indicate that the IGF-I-RF obtained from Holstein colostrum could be a useful component for an alternative therapeutic modality for the treatment of diabetes in insulin-resistant patients.
Department of Agrofood Resources, National Academy of Agricultural Science, Rural Development Administration, Nokjiro, Gwonseon-gu, Suwon, Republic of Korea. kah366@korea.kr
Kyung-A
KA
Hwang
Yu-Jin
YJ
Hwang
Woelkyu
W
Ha
Young-Kug
YK
Choo
Kisung
K
Ko
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D002417:Cattle; D003126:Colostrum / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D005951:Glucose Tolerance Test; D007334:Insulin-Like Growth Factor I / Q000737:chemistry / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D008894:Milk Proteins / Q000737:chemistry*; D009929:Organ Size; D011897:Random Allocation; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D014280:Triglycerides / Q000378:metabolism; D000067816:Whey Proteins
D001786:Blood Glucose; D008894:Milk Proteins; D014280:Triglycerides; D000067816:Whey Proteins; D007334:Insulin-Like Growth Factor I