Hepatotoxicity of silica nanoparticles with a diameter of 100 nm.
Nanomaterials have potential toxicity that is not found in micromaterials, and it is therefore essential to understand their biological activity and potential toxicity. We focused on silica nanoparticles, since it was previously reported that the intravenous administration of silica nanoparticles with a diameter of 70 nm (SP70) causes hepatic injury. In the present study, we focused on the effects of the particle diameter of silica. We found that silica nanoparticles caused acute liver toxicity at a diameter of 100 nm, and that liver sinusoidal endothelial cells are directly involved in silica nanoparticle-induced liver injury. These findings suggest that the diameter of nanoparticles has great influence on silica nanoparticle-induced liver injury.
Laboratory of Bio-Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
T
T
Hasezaki
K
K
Isoda
M
M
Kondoh
Y
Y
Tsutsumi
K
K
Yagi
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D002945:Cisplatin / Q000008:administration & dosage / Q000633:toxicity; D003287:Contrast Media / Q000008:administration & dosage / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000633:toxicity; D005682:Gadolinium / Q000008:administration & dosage / Q000633:toxicity; D022781:Hepatocytes / Q000187:drug effects / Q000473:pathology; D006540:Herbicides / Q000008:administration & dosage / Q000633:toxicity; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000633:toxicity; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D053758:Nanoparticles / Q000633:toxicity*; D010269:Paraquat / Q000008:administration & dosage / Q000633:toxicity; D010316:Particle Size; D012822:Silicon Dioxide / Q000633:toxicity*
D000970:Antineoplastic Agents; D003287:Contrast Media; D006540:Herbicides; D007166:Immunosuppressive Agents; D012822:Silicon Dioxide; D003520:Cyclophosphamide; D005682:Gadolinium; D000410:Alanine Transaminase; C038958:gadolinium chloride; D010269:Paraquat; D002945:Cisplatin