Stem cells and skin regeneration.
Stem cells represent a great hope for regenerative medicine. In adult life, stem cell deposits are kept in organ niches; the need for tissue or organ regeneration mobilizes stem cells via the SDF-1-CXCR4 regulation axis. Constant regeneration of the skin is achieved due to stem cell differentiation within the epidermis and the hair follicle; thus, skin may serve as an excellent source of stem cells. This is of paramount importance in the treatment of chronic skin wounds and burns.
Department of Physiology, Pomeranian Medical University, Szczecin, Poland. stanma@sci.pam.szczecin.pl
Marzena
M
Staniszewska
Sylwia
S
Słuczanowska-Głąbowska
Justyna
J
Drukała
D015415:Biomarkers / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology; D054377:Chemokine CXCL12 / Q000378:metabolism; D000078404:Epidermal Cells; D006801:Humans; D019718:Receptors, CXCR4 / Q000378:metabolism; D012038:Regeneration / Q000502:physiology*; D044968:Regenerative Medicine; D012867:Skin / Q000166:cytology* / Q000293:injuries / Q000473:pathology; D012879:Skin Physiological Phenomena; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*
D015415:Biomarkers; D054377:Chemokine CXCL12; D019718:Receptors, CXCR4