Association of CISH -292A/T genetic variant with hepatitis B virus infection.
Cytokine-inducible SRC homology 2 domain protein (CISH) is a suppressor of cytokine signaling that controls interleukin-2 signaling pathway. We investigated the single nucleotide polymorphism (SNP) -292A>T in 473 Vietnamese hepatitis B virus (HBV) carriers and 416 healthy controls. CISH variants at -292A>T were associated to HBV infection (Allelic: OR, 1.22 95% CI, 1-1.49; P = 0.04; Recessive: OR, 1.69 95% CI 1.23-2.54; P = 0.007). A gene dose effect for the risk allele -292T was observed (P = 0.04). The level of interleukin 2 and liver enzymes such as alanine transaminase, aspartate transaminase, total bilirubin, and direct bilirubin were not associated to CISH polymorphism at position -292A>T This study associated the vital role of CISH SNP -292A>T variant to hepatitis B virus infection in a Vietnamese population.
Institute of Tropical Medicine, University of Tübingen, Wilhelmstrasse, 27, 72074, Tübingen, Germany.
Hoang V
HV
Tong
Nguyen L
NL
Toan
Le H
le H
Song
Peter G
PG
Kremsner
Jürgen F J
JF
Kun
Velavan
V
Tp
D000483:Alleles; D044466:Asian People / Q000235:genetics; D016009:Chi-Square Distribution; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006509:Hepatitis B / Q000235:genetics*; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D050826:Suppressor of Cytokine Signaling Proteins / Q000235:genetics*; D014744:Vietnam
D050826:Suppressor of Cytokine Signaling Proteins