[Sex differentiation: state of the art and future prospects].
Our knowledge on sex differentiation in mammals has considerably progressed during the last decennials, beginning with the discovery of the testis-determining factor. Here, the morphogenetic processes involved in the early gonadic switch will be presented, together with the major genes involved in testis and ovary formation. Existing differences between the widely used mouse model and other mammals, such as human and goat, will be highlighted.
Inra, UMR1198-Biologie du développement et de la reproduction, Bâtiment J. Poly, Jouy-en-Josas, France.
Maëlle
M
Pannetier
Eric
E
Pailhoux
D000818:Animals; D005260:Female; D000074842:Forkhead Box Protein L2; D051858:Forkhead Transcription Factors / Q000502:physiology; D018628:Gene Dosage; D024282:Genes, sry; D006041:Goats / Q000502:physiology; D006728:Hormones / Q000502:physiology; D006801:Humans; D008297:Male; D008322:Mammals / Q000502:physiology; D051379:Mice / Q000502:physiology; D008954:Models, Biological; D009024:Morphogenesis; D010053:Ovary / Q000196:embryology / Q000254:growth & development; D012727:Sex Characteristics; D012730:Sex Chromosomes / Q000502:physiology; D019849:Sex Determination Processes / Q000235:genetics / Q000502:physiology*; D012733:Sex Differentiation / Q000235:genetics / Q000502:physiology*; D013045:Species Specificity; D013737:Testis / Q000196:embryology / Q000254:growth & development
C421604:FOXL2 protein, human; D000074842:Forkhead Box Protein L2; D051858:Forkhead Transcription Factors; C498893:Foxl2 protein, mouse; D006728:Hormones