Long, saturated chains: tasty domains for kinases of insulin resistance.
The mechanistic basis of how cells respond to increased fatty acids (FAs) is murky but potentially involves receptor-mediated activation or inhibition by different FA classes. Holzer et al. (2011) recently propose in Cell that expansion of intracellular membrane microdomains induced by saturated FA recruit and activate c-Src for JNK activation.
Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Vladimir
V
Lizunov
Petr
P
Chlanda
Mary
M
Kraft
Joshua
J
Zimmerberg