The role of resistin in Behçet's disease: a Turkish experiment.
The objective of this study was to assess the role of resistin, a proinflammatory cytokine potentially involved in Behçet's disease (BD), and to determine its relationship with tumor necrosis factor α (TNF-α), another important inflammatory cytokine known to be involved in BD. Forty-five persons diagnosed with BD were enrolled into this study, 25 of whom were being followed or had recently been diagnosed with clinically active BD, whereas the remaining 20 were previously diagnosed and had clinically inactive BD for the previous 3 months. Thirty persons were recruited as a healthy control group. Patients' C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), resistin, and TNF-α levels were determined with enzyme-linked immunosorbent assay (ELISA). Resistin and TNF-α levels were significantly higher in patients with BD (p < 0.05 and p < 0.05) than in the control group. The major interest of this study was to investigate the role of resistin in patients with BD. An elevated resistin level was associated with activation of BD. Elevated TNF-α and resistin levels could be determined simultaneously, and the presence of these two cytokines together suggests that resistin plays an important role in the pathogenesis and activation of BD.
Department of Rheumatology, Sahinbey Medical Center, School of Medicine, Gaziantep University, Gaziantep, 27310, Turkey. drpehlivan@hotmail.com
Yavuz
Y
Pehlivan
Ahmet Mesut
AM
Onat
Seydi
S
Okumuş
Bunyamin
B
Kisacik
Gazi
G
Comez
Aysegul
A
Comez
Fatih
F
Goktepe
Nurdan Ozlu
NO
Ceylan
D000328:Adult; D001528:Behcet Syndrome / Q000097:blood* / Q000175:diagnosis; D015415:Biomarkers / Q000378:metabolism; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D052243:Resistin / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
D015415:Biomarkers; C499624:RETN protein, human; D052243:Resistin; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein