[Effect of milk product with soy isoflavones on quality of life and bone metabolism in postmenopausal Spanish women: randomized trial].
OBJECTIVE
To analyze the effects of nutritional intervention with a milk product enriched with soy isoflavones on quality of life and bone metabolism in postmenopausal Spanish women.


METHODS
We performed a double-blind controlled randomized trial in ninety-nine postmenopausal women. Group S women (n=48) were randomized to consume milk product enriched with soy isoflavone (50 mg/day) while group C (n=51) consumed product control for 12 months. Parameters of quality of life (Cervantes scale), markers of bone metabolism and bone mass estimated by ultrasound of the calcaneus (QUS) were evaluated.


RESULTS
Overall, there was an improvement in the domains menopause (P=.015) and vasomotor symptoms (P<.001). S group emphasized the assessment of vasomotor symptoms (P=.001) and differed positively from group C in health (P=.019), sex (P=.021) and partner (P=.002). Serum levels TRAP (P<.001) and OPG (P=.007) decreased and concentrations of 25-OH-vitamin D increased (P<.001) without differences between groups. In the assessment of QUS, there was an increase in estimated bone mineral density in group S (P=.040), whereas in group C there were no significant differences.


CONCLUSIONS
Daily consumption of these milk products increases levels of 25-OH-vitamin D and decreases bone metabolism markers. Additional supplementation with soy isoflavones seems to improve quality of life and bone mass in Spanish postmenopausal women.
Servicio de Endocrinología y Nutrición, Hospital Universitario San Cecilio, Granada, España. garciamartin_t@hotmail.com
Antonia
A
García-Martín
Miguel
M
Quesada Charneco
Alejandro
A
Alvárez Guisado
José Juan
JJ
Jiménez Moleón
Juristo
J
Fonollá Joya
Manuel
M
Muñoz-Torres
D000135:Acid Phosphatase / Q000097:blood; D000368:Aged; D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D001842:Bone and Bones / Q000378:metabolism*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D019584:Hot Flashes / Q000517:prevention & control; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D007529:Isoflavones / Q000008:administration & dosage*; D008875:Middle Aged; D008892:Milk; D015663:Osteoporosis, Postmenopausal / Q000453:epidemiology / Q000517:prevention & control*; D053244:Osteoprotegerin / Q000097:blood; D017698:Postmenopause / Q000097:blood / Q000523:psychology; D011788:Quality of Life; D041942:Soy Milk; D013030:Spain / Q000453:epidemiology; D000071681:Tartrate-Resistant Acid Phosphatase; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood
D007527:Isoenzymes; D007529:Isoflavones; D053244:Osteoprotegerin; C506030:TNFRSF11B protein, human; D014807:Vitamin D; C104450:25-hydroxyvitamin D; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase