Use of a miniaturized cardiopulmonary bypass circuit in neonates and infants is associated with fewer blood product transfusions.
Miniaturized bypass circuits, including the Kids D100 oxygenator and the D130 arterial filter, were specially designed to reduce blood transfusions in small infants undergoing cardiac surgery. This study compared the number of blood product transfusions and short-term outcome between patients younger than 1 year undergoing cardiac surgery with a conventional and a miniaturized bypass circuit, after controlling for baseline characteristics and surgical complexity by 1:1 matching. Adjusted odds ratios (ORs) and 95% confidence intervals for exposure to transfusions and to any additional transfusion were estimated from binary and polytomous regression models. Of the 804 patients enrolled retrospectively, 246 were analyzed after matching. The use of the miniaturized circuit required a lower priming volume, 265.5 vs. 432.4 mL, p < 0.001, fewer packed red blood cell (PRBC) transfusions, 1.4 vs. 2.0 U, p < 0.001, and fewer platelet transfusions on the day of surgery, 57.7% vs. 76.4%, p < 0.001. After adjustment for the use of antifibrinolytics, the ultrafiltration rate, and the year of surgery, the use of the miniaturized circuit was independently related to a reduced risk of additional PRBC transfusions, OR 0.04 (0.01, 0.13), and exposure to platelet transfusions, OR 0.78 (0.63, 0.96). Short-term outcome was similar.
Anesthesiolgy and Critical Care Department, Necker-Enfants Malades Hospital, Assistance Publique-Hopitaux de Paris, France. mirela.bojan@nck.aphp.fr
Mirela
M
Bojan
Maria
M
Constanza Basto Duarte
Vanessa
V
Lopez Lopez
Laurent
L
Tourneur
Philippe
P
Pouard
Pascal
P
Vouhé
D016913:Blood Component Transfusion / Q000706:statistics & numerical data*; D002315:Cardiopulmonary Bypass / Q000295:instrumentation*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D012189:Retrospective Studies