Stable disruption of ethanol production by deletion of the genes encoding alcohol dehydrogenase isozymes in Saccharomyces cerevisiae.
We analyzed the effects of the deletions of genes encoding alcohol dehydrogenase (ADH) isozymes of Saccharomyces cerevisiae. The decrease in ethanol production by ADH1 deletion alone could be partially compensated by the upregulation of other isozyme genes, while the deletion of all known ADH isozyme genes stably disrupted ethanol production.
Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University, 1-5 Yamadaoka, Suita, Osaka 565-0871, Japan.
Yoshihiro
Y
Ida
Chikara
C
Furusawa
Takashi
T
Hirasawa
Hiroshi
H
Shimizu
D000426:Alcohol Dehydrogenase / Q000235:genetics* / Q000378:metabolism; D000431:Ethanol / Q000378:metabolism*; D017353:Gene Deletion; D005800:Genes, Fungal; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*
D007527:Isoenzymes; D000431:Ethanol; D000426:Alcohol Dehydrogenase