Is diastolic dysfunction associated with atrial electrocardiographic parameters in Behçet's disease?
BACKGROUND
The impact of Behçet's disease (BD) on the vascular bed is highly important, as this condition may lead to heart failure from asymptomatic systolic and diastolic dysfunction. Our aim was to evaluate diastolic functions using new echocardiographic parameters and the correlation of these parameters with atrial electrocardiographic (ECG) indices in patients with BD.


METHODS
31 patients with BD and 31 healthy control subjects were enrolled to this study. Left ventricular (LV) diastolic functions were examined with conventional and tissue Doppler echocardiography. P-wave dispersion (PD) was calculated by measuring minimum and maximum P-wave duration values on the 12-lead surface ECG. The relationship between PD and echocardiographic parameters of diastolic dysfunction were investigated.


RESULTS
The mitral inflow E/A ratio and diastolic myocardial velocity ratio (Em/Am) were lower in the BD group (P < 0.001 and P < 0.001, respectively). The E/Em ratio and left atrial volume index (LAVi) were higher in the BD group (P < 0.001 and P = 0.014, respectively) compared to healthy control subjects. P max and PD were significantly higher in the BD group (P < 0.001 and P < 0.001). PD correlated positively with the duration of BD. Also, PD correlated positively with LAVi and E/Em ratio, but negatively with E/A and Em/Am ratios.


CONCLUSIONS
In this study, we demonstrated that LV diastolic functions are impaired in BD patients. Furthermore, P-wave abnormalities were demonstrated in BD patients and there was a significant correlation between PD and diastolic dysfunction.
Department of Cardiology, Gaziosmanpasa University School of Medicine, Tokat, Turkey. drfatkoc@gmail.com
Fatih
F
Koc
Sema
S
Koc
Jale
J
Yuksek
Mehmet Akif
MA
Vatankulu
Kerem
K
Ozbek
Enes Elvin
EE
Gul
Atac
A
Celik
Ahmet
A
Inanir
Hasan
H
Kadi
Koksal
K
Ceyhan
Metin
M
Karayakali
Ahmet
A
Ozturk
D000328:Adult; D000465:Algorithms; D016275:Atrial Function; D001528:Behcet Syndrome / Q000150:complications*; D016022:Case-Control Studies; D003971:Diastole; D004562:Electrocardiography; D005260:Female; D006325:Heart Atria / Q000000981:diagnostic imaging / Q000503:physiopathology; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014463:Ultrasonography; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology*