Ring cleavage and successive aldol reaction of 3-[(trialkylsilyl)methyl]cyclobutanones.
3-[(Trialkylsilyl)methyl]cyclobutanones reacted with aldehydes by activation with titanium(IV) chloride to give acyclic β,γ-unsaturated β'-hydroxyketones.
School of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.
Jun-ichi
J
Matsuo
Kosuke
K
Harada
Mizuki
M
Kawano
Ryosuke
R
Okuno
Hiroyuki
H
Ishibashi
D000447:Aldehydes / Q000737:chemistry; D000478:Alkylation; D003503:Cyclobutanes / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure
D000447:Aldehydes; D003503:Cyclobutanes; C116609:3-hydroxybutanal