Human cardiac autonomic responses to head-up tilting during 72-h starvation.
Starvation may change autonomic nervous system activity and sensitivity such that a greater vagal withdrawal may occur during a sympathetic challenge. Six healthy humans endured a 3-day, water-only fast, during which participants were subjected to passive 80° head-up tilt testing twice on each day (a.m. and p.m.). Heart rate, heart rate variability (HRV), ventilation [Formula: see text], and respiration ([Formula: see text] and [Formula: see text]) were recorded during supine rest and head-up tilting. On Day 1 (a.m.), supine heart rate was 46.0 ± 3.3 beats min(-1), increasing to 51.6 ± 7.4 beats min(-1) on Day 3 (p.m.). On Day 1 (a.m.), supine high frequency HRV was 57.9 ± 31.6(NU), increasing to 69.5 ± 21.3(NU) on Day 3 (p.m.). Tilt-induced increases in heart rate were greater following starvation (10.5 ± 7.8 vs. 16.1 ± 8.6 beats min(-1)), and tilt-induced decreases in high frequency HRV were greater following starvation (-4.1 ± 27.7 vs. -28.0 ± 20.8(NU)). Supine V'CO(2) remained unchanged, whereas V'O(2) increased and respiratory exchange ratio decreased (0.91 ± 0.10 vs. 0.80 ± 0.05). Greater vagal withdrawal and elevated heart rate induced by head-up tilting during starvation may indicate increased autonomic sensitivity.
School of Sport and Exercise, Massey University, Auckland, New Zealand. s.j.brown@massey.ac.nz
Stephen J
SJ
Brown
M
M
Bryant
T
T
Mündel
S R
SR
Stannard
D000328:Adult; D001341:Autonomic Nervous System / Q000502:physiology*; D015992:Body Mass Index; D005260:Female; D006257:Head / Q000502:physiology; D006321:Heart / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D011187:Posture / Q000502:physiology; D012119:Respiration; D013217:Starvation / Q000503:physiopathology*; D018667:Tilt-Table Test / Q000379:methods; D014630:Vagus Nerve / Q000502:physiology