Mixed ductal-endocrine carcinoma of the pancreas occurring as a double cancer: report of a case.
We present a successfully treated case of mixed ductal-endocrine carcinoma of the pancreas complicated by right renal cell carcinoma. The patient had no symptoms, and laboratory data were close to the normal range. Enhanced computed tomography demonstrated a marked enhanced tumor, which appeared to be an endocrine tumor, at the pancreas uncus. We performed pyrolus-preserving pancreaticoduodenectomy, regional lymph node resection, and right nephrectomy. Histologically and immunohistochemically, the pancreas tumor had both a ductal (exocrine) and an endocrine component. The renal tumor was a typical clear cell carcinoma. A diagnosis of synchronous double cancer was made. As demonstrated in previously published reports, this type of mixed tumor has malignant potential for invasive ductal carcinoma. We propose that mixed ductal-endocrine carcinoma of the pancreas should be treated by surgical resection with a sufficient surgical margin and regional lymph node resection to improve the patient's prognosis.
Department of General Surgical Science (Surgery I), Gunma University Graduate School of Medicine, Gunma, Japan. karaki@showa.gunma-u.ac.jp
Kenichiro
K
Araki
Tatsuo
T
Shimura
Tsutomu
T
Kobayashi
Kana
K
Saito
Wataru
W
Wada
Shigeru
S
Sasaki
Hideki
H
Suzuki
Kenji
K
Kashiwabara
Takashi
T
Nakajima
Hiroyuki
H
Kuwano
D000368:Aged; D018278:Carcinoma, Neuroendocrine / Q000378:metabolism / Q000473:pathology*; D021441:Carcinoma, Pancreatic Ductal / Q000378:metabolism / Q000473:pathology*; D002292:Carcinoma, Renal Cell / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D007680:Kidney Neoplasms / Q000473:pathology* / Q000601:surgery; D008198:Lymph Nodes / Q000601:surgery; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D009392:Nephrectomy; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D016577:Pancreaticoduodenectomy; D011379:Prognosis
D019394:Ki-67 Antigen