Regulation and dysregulation of epithelial Na+ channels.
Epithelial Na(+) channels (ENaC) form a highly regulated pathway for the reabsorption of Na(+) from urine. This regulation can take place at a number of different levels, including synthesis of channel protein, trafficking of the protein between the surface and internal membranes, proteolytic cleavage and channel gating. This article reviews the role of these different modes of regulation under physiological conditions and considers the possible contributions of dysregulation of these processes in disease states, particularly hypertension.
Department of Physiology and Biophysics, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10065, USA. lgpalm@med.cornell.edu
Lawrence G
LG
Palmer
Ankit
A
Patel
Gustavo
G
Frindt
D000450:Aldosterone / Q000502:physiology; D000818:Animals; D053503:Epithelial Sodium Channels / Q000187:drug effects / Q000502:physiology*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D007668:Kidney / Q000502:physiology; D058470:Receptors, Purinergic P2Y / Q000502:physiology; D012697:Serine Endopeptidases / Q000378:metabolism; D012964:Sodium / Q000494:pharmacology; D000099271:Prostasin
D000450:Aldosterone; D053503:Epithelial Sodium Channels; D048049:Extracellular Signal-Regulated MAP Kinases; D058470:Receptors, Purinergic P2Y; D012697:Serine Endopeptidases; D012964:Sodium; D000099271:Prostasin