Fever-induced QTc prolongation and ventricular fibrillation in a healthy young man.
Long QT syndrome is associated with lethal tachyarrhythmia that can lead to syncope, seizure, and sudden death. Congenital long QT syndrome is a genetic disorder, characterized by delayed cardiac repolarization and prolongation of the QT interval on the electrocardiogram (ECG). Type 2 congenital long QT is linked to mutations in the human ether a go-go-related gene (HERG). There are environmental triggers of adverse cardiac events such as emotional and acoustic stimuli, but fever can also be a potential trigger of life-threatening arrhythmias in long QT syndrome type 2 patients. Herein, we report a healthy young man who experienced fever-induced polymorphic ventricular tachycardia and QT interval prolongation.
Division of Cardiology, Yonsei University College of Medicine, Seoul, Korea.
Sun Min
SM
Lim
Hui-Nam
HN
Pak
Moon-Hyoung
MH
Lee
Sung Soon
SS
Kim
Boyoung
B
Joung
D000328:Adult; D004562:Electrocardiography; D005334:Fever / Q000150:complications*; D006801:Humans; D008133:Long QT Syndrome / Q000175:diagnosis* / Q000209:etiology*; D008297:Male; D014693:Ventricular Fibrillation / Q000175:diagnosis* / Q000209:etiology*