[Evaluation of Brn-3a immunocytochemistry of liquid-based ThinPrep cytology test in early diagnosis of cervical process].
OBJECTIVE
To investigate the value of Brn-3a immunocytochemistry of liquid-based ThinPrep cytology test(TCT) in early diagnosis of cervical process.


METHODS
Patients(192) were investigated in the present study. TCT was used in all the patients. Immunohistochemistry was per-formed to examine the expressions of Brn-3a. The pathological results were used as the gold standard to evaluate the results of TCT method and Brn-3a in combination with LCT.


RESULTS
Compared with the pathological results, the accuracies of TCT method were 76.9% (30/39) , 80.5% (33/41)and 96.8% (30/31) in LSIL, HSIL, SCC respectively. The accuracies of Brn-3a in combination with TCT were 76. 9%(30/39), 78.6%(33/42) and 97.1% (30/31) in LSIL, HSIL and SCC respectively. The difference was significant in the diagnosis of LSIL and HSIL (P <0.05).


CONCLUSIONS
The detection of Brn-3a is of important clinic value in early diagnosis of cervical process.
Department of Pathology, 302 Hospital of PLA, Beijing, China.
Xiao-dong
XD
Guo
Ke
K
Niu
Jing-minI
JM
Zhao
Lu
L
Xiong
Xin
X
Zhang
Yu-lai
YL
Zhao
D000328:Adult; D055088:Early Detection of Cancer / Q000379:methods*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods*; D008875:Middle Aged; D050819:Transcription Factor Brn-3A / Q000378:metabolism*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology; D055815:Young Adult
D050819:Transcription Factor Brn-3A