Differentiation pathways in carcinogenesis and in chemo- and radioresistance.
Cancer stem cells (CSCs) share many features with embryonic stem cells (ESCs) such as the ability for self-renewal and differentiation. Signaling pathways that are involved in these processes are also involved in chemo- and radioresistance (e.g. Wnt, Notch and Hedgehog pathways). This review is focused on the influence of three important differentiation pathways on carcinogenesis and on chemo- and radioresistance in ESCs and CSCs.
Department of Clinical and Molecular Pathology, Palacky University , Czech Republic.
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M
Janikova
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J
Skarda
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D002471:Cell Transformation, Neoplastic; D019008:Drug Resistance, Neoplasm / Q000502:physiology*; D053595:Embryonic Stem Cells / Q000166:cytology / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D015972:Gene Expression Regulation, Neoplastic; D053823:Hedgehog Proteins / Q000502:physiology; D006801:Humans; D009363:Neoplasm Proteins / Q000502:physiology; D014411:Neoplastic Stem Cells / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000502:physiology; D011836:Radiation Tolerance / Q000502:physiology*; D051880:Receptors, Notch / Q000502:physiology; D051153:Wnt Proteins / Q000502:physiology
D053823:Hedgehog Proteins; D009363:Neoplasm Proteins; D051880:Receptors, Notch; D051153:Wnt Proteins