Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2.
To identify susceptibility loci for schizophrenia, we performed a two-stage genome-wide association study (GWAS) of schizophrenia in the Han Chinese population (GWAS: 746 individuals with schizophrenia and 1,599 healthy controls; validation: 4,027 individuals with schizophrenia and 5,603 healthy controls). We identified two susceptibility loci for schizophrenia at 6p21-p22.1 (rs1233710 in an intron of ZKSCAN4, P(combined) = 4.76 × 10(-11), odds ratio (OR) = 0.79; rs1635 in an exon of NKAPL, P(combined) = 6.91 × 10(-12), OR = 0.78; rs2142731 in an intron of PGBD1, P(combined) = 5.14 × 10(-10), OR = 0.79) and 11p11.2 (rs11038167 near the 5' UTR of TSPAN18, P(combined) = 1.09 × 10(-11), OR = 1.29; rs11038172, P(combined) = 7.21 × 10(-10), OR = 1.25; rs835784, P(combined) = 2.73 × 10(-11), OR = 1.27). These results add to previous evidence of susceptibility loci for schizophrenia at 6p21-p22.1 in the Han Chinese population. We found that NKAPL and ZKSCAN4 were expressed in postnatal day 0 (P0) mouse brain. These findings may lead to new insights into the pathogenesis of schizophrenia.
Institute of Mental Health, Peking University, Beijing, China.
Wei-Hua
WH
Yue
Hai-Feng
HF
Wang
Liang-Dan
LD
Sun
Fu-Lei
FL
Tang
Zhong-Hua
ZH
Liu
Hong-Xing
HX
Zhang
Wen-Qiang
WQ
Li
Yan-Ling
YL
Zhang
Yang
Y
Zhang
Cui-Cui
CC
Ma
Bo
B
Du
Li-Fang
LF
Wang
Yun-Qing
YQ
Ren
Yong-Feng
YF
Yang
Xiao-Feng
XF
Hu
Yi
Y
Wang
Wei
W
Deng
Li-Wen
LW
Tan
Yun-Long
YL
Tan
Qi
Q
Chen
Guang-Ming
GM
Xu
Gui-Gang
GG
Yang
Xian-bo
XB
Zuo
Hao
H
Yan
Yan-Yan
YY
Ruan
Tian-Lan
TL
Lu
Xue
X
Han
Xiao-Hong
XH
Ma
Yan
Y
Wang
Li-Wei
LW
Cai
Chao
C
Jin
Hong-Yan
HY
Zhang
Jun
J
Yan
Wei-Feng
WF
Mi
Xian-Yong
XY
Yin
Wen-Bin
WB
Ma
Qi
Q
Liu
Lan
L
Kang
Wei
W
Sun
Cheng-Ying
CY
Pan
Mei
M
Shuang
Fu-De
FD
Yang
Chuan-Yue
CY
Wang
Jian-Li
JL
Yang
Ke-Qing
KQ
Li
Xin
X
Ma
Ling-Jiang
LJ
Li
Xin
X
Yu
Qi-Zhai
QZ
Li
Xun
X
Huang
Lu-Xian
LX
Lv
Tao
T
Li
Guo-Ping
GP
Zhao
Wei
W
Huang
Xue-Jun
XJ
Zhang
Dai
D
Zhang
D000328:Adult; D000818:Animals; D044466:Asian People; D001921:Brain / Q000378:metabolism; D016022:Case-Control Studies; D002880:Chromosomes, Human, Pair 11; D002896:Chromosomes, Human, Pair 6; D056970:Co-Repressor Proteins / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009419:Nerve Tissue Proteins / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D025341:Principal Component Analysis; D040641:Quantitative Trait Loci; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*; D059470:Tetraspanins / Q000235:genetics; D014158:Transcription, Genetic
D056970:Co-Repressor Proteins; D004268:DNA-Binding Proteins; C569368:NKAPL protein, human; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; C569369:PGBD1 protein, human; C556852:TSPAN18 protein, human; D059470:Tetraspanins; C524688:ZKSCAN4 protein, human