Chemical constituents of Kigelia pinnata twigs and their GLUT4 translocation modulatory effect in skeletal muscle cells.
Phytochemical investigation of the ethanolic extract of twigs of Kigelia pinnata DC. afforded one new iridoid 7-hydroxy eucommiol (1), and nine known compounds (2-10). The structure of compounds was elucidated by extensive spectroscopic methods, including 1D, 2D NMR experiments and MS analysis. All these compounds were evaluated for GLUT4 translocation modulatory effect in skeletal muscle cells. Four of the tested compounds 1, 5, 6 and 7 showed significant stimulation of GLUT4 translocation to cell surface in skeletal muscle cells without any adverse effect on cell viability. Effect of these four compounds was concentration-dependent and comparable to standard drug rosiglitazone. These findings indicate that constituents of K. pinnata may provide leads for the therapeutics for insulin resistance and diabetes.
Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226 001, India.
Mohammad Faheem
MF
Khan
Preety
P
Dixit
Natasha
N
Jaiswal
Akhilesh Kumar
AK
Tamrakar
Arvind Kumar
AK
Srivastava
Rakesh
R
Maurya
D000818:Animals; D029402:Bignoniaceae / Q000737:chemistry*; D051275:Glucose Transporter Type 4 / Q000235:genetics / Q000378:metabolism*; D015394:Molecular Structure; D018485:Muscle Fibers, Skeletal / Q000187:drug effects; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D021381:Protein Transport; D051381:Rats
D051275:Glucose Transporter Type 4; D010936:Plant Extracts