The motors of protein import into chloroplasts.
Chloroplast function is largely dependent on its resident proteins, most of which are encoded by the nuclear genome and are synthesized in cytosol. Almost all of these are imported through the translocons located in the outer and inner chloroplast envelope membranes. The motor protein that provides the driving force for protein import has been proposed to be Hsp93, a member of the Hsp100 family of chaperones residing in the stroma. Combining in vivo and in vitro approaches, recent publications have provided multiple lines of evidence demonstrating that a stromal Hsp70 system is also involved in protein import into this organelle. Thus it appears that protein import into chloroplasts is driven by two motor proteins, Hsp93 and Hsp70. A perspective on collaboration between these two chaperones is discussed.
Department of Plant Biology, University of California, Davis, CA, USA. lshi@ucdavis.edu
Lan-Xin
LX
Shi
Steven M
SM
Theg
D017360:Arabidopsis / Q000378:metabolism; D029681:Arabidopsis Proteins / Q000378:metabolism; D002736:Chloroplasts / Q000378:metabolism*; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000378:metabolism; D010940:Plant Proteins / Q000378:metabolism*; D021381:Protein Transport / Q000502:physiology
D029681:Arabidopsis Proteins; D018840:HSP70 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D010940:Plant Proteins