Correlation of cystatin-C with glomerular filtration rate by inulin clearance in pregnancy.
OBJECTIVE
To test utility of cystatin-C as a marker of glomerular filtration rate during pregnancy, we performed serial correlations with inulin clearance during pregnancy and postpartum.


METHODS
Twelve subjects received inulin infusions and serum cystatin-C at three time points. Pearson's correlation coefficient was calculated.


RESULTS
Cystatin-C levels ranged 0.66-1.48 mg/L during pregnancy, and 0.72-1.26 mg/L postpartum. Inulin clearance ranged 130-188 mL/min during pregnancy, and 110-167 mL/min postpartum. Cystatin-C did not correlate with inulin clearance at any time point.


CONCLUSIONS
Serum cystatin-C did not correlate with inulin clearance during pregnancy or postpartum.
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. asaxena@partners.org
A R
AR
Saxena
S
S
Ananth Karumanchi
S-L
SL
Fan
G L
GL
Horowitz
N K
NK
Hollenberg
S W
SW
Graves
E W
EW
Seely
D000328:Adult; D015415:Biomarkers / Q000097:blood; D055316:Cystatin C / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007444:Inulin; D049590:Postpartum Period / Q000502:physiology; D011247:Pregnancy / Q000502:physiology*; D011262:Pregnancy Trimester, Second / Q000502:physiology; D011263:Pregnancy Trimester, Third / Q000502:physiology
D015415:Biomarkers; C525030:CST3 protein, human; D055316:Cystatin C; D007444:Inulin