Ionic liquid-based microwave-assisted dispersive liquid-liquid microextraction and derivatization of sulfonamides in river water, honey, milk, and animal plasma.
The ionic liquid-based microwave-assisted dispersive liquid-liquid microextraction (IL-based MADLLME) and derivatization was applied for the pretreatment of six sulfonamides (SAs) prior to the determination by high-performance liquid chromatography (HPLC). By adding methanol (disperser), fluorescamine solution (derivatization reagent) and ionic liquid (extraction solvent) into sample, extraction, derivatization, and preconcentration were continuously performed. Several experimental parameters, such as the type and volume of extraction solvent, the type and volume of disperser, amount of derivatization reagent, microwave power, microwave irradiation time, pH of sample solution, and ionic strength were investigated and optimized. When the microwave power was 240 W, the analytes could be derivatized and extracted simultaneously within 90 s. The proposed method was applied to the analysis of river water, honey, milk, and pig plasma samples, and the recoveries of analytes obtained were in the range of 95.0-110.8, 95.4-106.3, 95.0-108.3, and 95.7-107.7, respectively. The relative standard deviations varied between 1.5% and 7.3% (n=5). The results showed that the proposed method was a rapid, convenient and feasible method for the determination of SAs in liquid samples.
College of Chemistry, Jilin University, Changchun 130012, PR China.
Xu
X
Xu
Rui
R
Su
Xin
X
Zhao
Zhuang
Z
Liu
Yupu
Y
Zhang
Dan
D
Li
Xueyuan
X
Li
Hanqi
H
Zhang
Ziming
Z
Wang
D000818:Animals; D006722:Honey / Q000032:analysis*; D052578:Ionic Liquids / Q000032:analysis / Q000737:chemistry; D059627:Liquid Phase Microextraction / Q000295:instrumentation / Q000379:methods*; D008872:Microwaves; D008892:Milk / Q000737:chemistry*; D045483:Rivers / Q000737:chemistry*; D013449:Sulfonamides / Q000032:analysis / Q000097:blood*; D013552:Swine; D014867:Water / Q000032:analysis* / Q000737:chemistry; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000737:chemistry
D052578:Ionic Liquids; D013449:Sulfonamides; D014874:Water Pollutants, Chemical; D014867:Water