[Preparation and in vitro characterization of apigemin-loaded nanostructured lipid carriers].
OBJECTIVE
To prepare Apigemin-loaded nanostructured lipid carriers (Api-NLCs) and evaluate their characteristics.


METHODS
Api-NLCs were prepared by the method of emulsion evaporation-solidification at low temperature. The physicochemical properties such as morphology, size distribution, zeta potential, entrapment efficiency, drug loading and drug release in vitro were evaluated.


RESULTS
The obtained nanoparticles were spherical under transmission electron microscope. The mean diameter was 212.1 nm, the zeta potential was - 14.65 mV, the mean entrapment efficiency was 82.4% and the mean drug loading was 0.97%. The total drug release was 30% in 2 hours followed by a slow and sustained release in vitro.


CONCLUSIONS
The optimal Api-NLCs show stable characteristics and broad prospects for application.
College of Pharmacy, Shandong University, Jinan 250012, China. zhaiyingjiemp5@163.com
Ying-jie
YJ
Zhai
Chen-yu
CY
Guo
Jin-ning
JN
Hou
Wei-dong
WD
Zhang
Guang-xi
GX
Zhai
D047310:Apigenin / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D019540:Area Under Curve; D003692:Delayed-Action Preparations / Q000138:chemical synthesis; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D004355:Drug Stability; D008055:Lipids / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D010743:Phospholipids / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008055:Lipids; D010743:Phospholipids; D013501:Surface-Active Agents; D047310:Apigenin