The N-end rule pathway: emerging functions and molecular principles of substrate recognition.
The N-end rule defines the protein-destabilizing activity of a given amino-terminal residue and its post-translational modification. Since its discovery 25 years ago, the pathway involved in the N-end rule has been thought to target only a limited set of specific substrates of the ubiquitin-proteasome system. Recent studies have provided insights into the components, substrates, functions and structural basis of substrate recognition. The N-end rule pathway is now emerging as a major cellular proteolytic system, in which the majority of proteins are born with or acquire specific N-terminal degradation determinants through protein-specific or global post-translational modifications.
Center for Pharmacogenetics and Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania         15261, USA.
Shashikanth M
SM
Sriram
Bo Yeon
BY
Kim
Yong Tae
YT
Kwon
D000107:Acetylation; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D006801:Humans; D008954:Models, Biological; D008958:Models, Molecular; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D055550:Protein Stability; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction; D055672:Static Electricity; D013379:Substrate Specificity
D000596:Amino Acids; D011506:Proteins