Effect of regional anesthesia on the success rate of external cephalic version: a systematic review and meta-analysis.
OBJECTIVE
To estimate whether the use of regional anesthesia is associated with increased success of external cephalic version.


METHODS
We searched MEDLINE, EMBASE, the Cochrane Library, and clinical trial registries.


METHODS
Electronic databases were searched from 1966 through April 2011 for published, randomized controlled trials in the English language comparing regional anesthesia with no regional anesthesia for external cephalic version. The primary outcome was external cephalic version success. Secondary outcomes included cesarean delivery, maternal discomfort, and adverse events. Pooled risk ratios (relative risk) were calculated using a random-effects model. Heterogeneity was assessed using the Cochran's Q statistic and quantified using the I Z method.


RESULTS
Six randomized controlled trials met criteria for study inclusion. Regional anesthesia was associated with a higher external cephalic version success rate compared with intravenous or no analgesia (59.7% compared with 37.6%; pooled relative risk 1.58; 95% confidence interval [CI] 1.29-1.93). This significant association persisted when the data were stratified by type of regional anesthesia (spinal compared with epidural). The number needed to treat with regional anesthesia to achieve one additional successful external cephalic version was five. There was no evidence of statistical heterogeneity (P=.32, I Z=14.9%) or publication bias (Harbord test P=.78). There was no statistically significant difference in the risk of cesarean delivery comparing regional anesthesia with intravenous or no analgesia (48.4% compared with 59.3%; pooled relative risk 0.80; 95% CI 0.55-1.17). Adverse events were rare and not significantly different between the two groups.


CONCLUSIONS
Regional anesthesia is associated with a higher success rate of external cephalic version.
From the Departments of Obstetrics & Gynecology and Surgery, Washington University in St Louis, St Louis, Missouri.
Katherine R
KR
Goetzinger
Lorie M
LM
Harper
Methodius G
MG
Tuuli
George A
GA
Macones
Graham A
GA
Colditz
D000765:Anesthesia, Conduction; D005260:Female; D006801:Humans; D011247:Pregnancy; D016032:Randomized Controlled Trials as Topic; D014710:Version, Fetal