[Study on allergenicity of chlorogenic acid in Qingkailing injection].
OBJECTIVE
To observe the allergenicity of chlorogenic acid (CA) in Qingkailing injection.


METHODS
CA was administrated to Beagle dogs through intravenous injection, and on experimental allergic sensitization of guinea pigs, it was through intraperitoneal and intravenous injection. The behavioral changes of Beagle dogs and guinea pigs were observed, and changes of the content of histamine, IgE, IgG, IgM, ECP and IL-4 in blood were detected. Then the allergenicity of CA was determined by experimental anaphylactoid and allergic methods.


RESULTS
There were no typical behavioral changes and increasement of the content of histamine, IgE, IgG, IgM, ECP and IL-4 in blood.


CONCLUSIONS
CA can not provoke anaphylactoid and allergic reactions.
Experimental Research Center, China Academy of Chinese Medical Scinces, Beijing 100700, China. zhgw68_8@tom.com
Zhiguo
Z
Wang
Danqiao
D
Wang
Youhua
Y
Yu
Yu
Y
Sui
Haifeng
H
Cui
Meiyu
M
Zhang
D000485:Allergens / Q000009:adverse effects*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002726:Chlorogenic Acid / Q000009:adverse effects*; D004285:Dogs; D004342:Drug Hypersensitivity / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry*; D005260:Female; D006168:Guinea Pigs; D007267:Injections; D008297:Male
D000485:Allergens; D004365:Drugs, Chinese Herbal; C504928:Qingkailing; D002726:Chlorogenic Acid