[Relationship between myocardial modelling and diastolic function in patients with essential hypertension].
OBJECTIVE
To analyze the relationship between sFas and soluble TNF receptor 1 (sTNF-R1) with type iii (PIIINP) and i (PINP) amino-terminal propeptide procollagens, and diastole in hypertension (HT).


METHODS
A group of 253 Caucasian asymptomatic hypertensive patients (age 60±13 years, 139 males) were studied, in whom a physical examination, laboratory analyses (determination of serum PIIINP, PINP, sFas and by radioimmunoassay and ELISA, respectively), and echo-Doppler study were performed.


RESULTS
Serum PINP and PIIINP were increased in left ventricular hypertrophy compared to non-hypertrophy [41 (31-52) vs. 35 (28-47) μg/l, P=.010; and 4.33 (3.71-5.29) vs. 3.98 (3.49-4.58) μg/l, P=.005, respectively]. Furthermore, sFas and sTNF-R1 were also elevated [1.47 (1.2-1.77) vs. 1.37 (1.1-1.59), P=.012; and 466 (331-657) vs. 317 (260-427) μg/l, P<.0001, respectively]. Moreover, serum PIIINP was associated with sFas (r=.386, P<.0001) and sTNF-R1 (r=.298, P<.001); PINP was also associated with these cytokines (r=0.158, P=.011 and r=.241, P<.0001, respectively). Multivariable analyses included sFas (P<.0001) and sTNF-R1 (P<.0001) as independent factors related with serum PIIINP. Finally, marker concentrations were significantly related with left ventricular diastolic function parameters.


CONCLUSIONS
Procollagen and anti-apoptotic cytokine levels were increased in our hypertrophic patients. Furthermore, sFas and sTNF-R1 are independent related factors of serum PIIINP. Diastolic parameters were associated with myocardial fibrosis and anti-apoptotic cytokines.
Unidad de Cardiocirculación, Hospital Universitario y Politécnico La Fe, Valencia, España.
Raquel
R
Cortés
Esther
E
Roselló-Lletí
Manuel
M
Portolés
Luis
L
Almenar
Luis
L
Martínez-Dolz
Lilian
L
Grigorian
Fernando
F
García de Burgos
Nuria
N
Carpena
Antonio
A
Salvador
Vicente
V
Bertomeu
Miguel
M
Rivera
D000368:Aged; D015415:Biomarkers / Q000097:blood; D018618:Echocardiography, Doppler, Color; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010446:Peptide Fragments / Q000097:blood*; D011347:Procollagen / Q000097:blood*; D011863:Radioimmunoassay; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000097:blood*; D012307:Risk Factors; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling; D019014:fas Receptor / Q000097:blood*
D015415:Biomarkers; C491901:FAS protein, human; D010446:Peptide Fragments; D011347:Procollagen; D047888:Receptors, Tumor Necrosis Factor, Type I; D019014:fas Receptor; C047202:procollagen Type I N-terminal peptide; C041876:procollagen Type III-N-terminal peptide