Mesenchymal stem cell therapy and delivery systems in nonhealing wounds.
OBJECTIVE
The objective of the study was to inform wound care practitioners of mesenchymal stem cell application for nonhealing wounds. Recent advances in delivery systems are also discussed in order to highlight potential improvements toward clinical application of stem cell therapy for chronic wounds.


METHODS
MEDLINE and PubMed Central were searched for scientific studies regarding the use of mesenchymal stem cells and delivery systems in wound healing.


METHODS
Preclinical studies using stem cells as therapeutic modality for chronic wounds were selected for this review.


METHODS
Information on study design, sample size and characteristics, stem cell source, type of delivery systems, and rate and time of wound closure was abstracted.


RESULTS
Application of mesenchymal stem cells improved wound healing in experimental and clinical settings. Advances in stem cell therapy and delivery vehicles offer promising alternatives to current limited therapeutic modalities for chronic wounds.


CONCLUSIONS
Stem cell therapy has recently emerged as a promising therapeutic strategy for nonhealing wounds. Further research is needed to evaluate the relationship between the various delivery systems and stem cells in order to maximize their therapeutic effects. Development of novel delivery vehicles for stem cells can open new opportunities for more effective cell therapy of chronic wounds.
Tufts University, School of Medicine, Boston, Massachusetts, USA.
Jonathan
J
Brower
Sheila
S
Blumberg
Emily
E
Carroll
Irena
I
Pastar
Harold
H
Brem
Weiliam
W
Chen
D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen; D006801:Humans; D020100:Hydrogels; D045164:Mesenchymal Stem Cell Transplantation / Q000295:instrumentation / Q000379:methods*; D017211:Treatment Failure; D014945:Wound Healing; D014947:Wounds and Injuries / Q000628:therapy*
D015718:Fibrin Tissue Adhesive; D020100:Hydrogels; D005340:Fibrinogen