Microfluidic approaches for gene delivery and gene therapy.
Recent advances in microfluidics have created new and exciting prospects for gene delivery and therapy. The micro-scaled environment within microfluidic systems enables precise control and optimization of multiple processes and techniques used in gene transfection and the production of gene and drug transporters. Traditional non-viral gene transfection methods, such as electroporation, microinjection and optical gene transfection, are improved from the use of innovative microfluidic systems. Additionally, microfluidic systems have also made the production of many viral and non-viral vectors controlled, automated, and reproducible. In summary, the development and application of microfluidic systems are producing increased efficiency in gene delivery and promise improved gene therapy results.
Department of Chemistry and Electrical Engineering, University of California, Berkeley, CA, USA.
Jungkyu
J
Kim
Inseong
I
Hwang
Derek
D
Britain
Taek Dong
TD
Chung
Yu
Y
Sun
Deok-Ho
DH
Kim
D000818:Animals; D018014:Gene Transfer Techniques / Q000295:instrumentation; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation; D014162:Transfection