Main constituents from the seeds of Vietnamese Cnidium monnieri and cytotoxic activity.
From the ethyl acetate extract of the seeds of Vietnamese Cnidium monnieri L., three coumarins, osthole (1), xanthotoxin (2), imperatorin (3) and a sterol, daucosterol (4) have been purified. Their structures were elucidated by spectroscopic analysis. Furthermore, 8-(3-hidroxy-3-methylbutyl)-7-methoxycoumarin (5) was synthesised from osthole (1) with a good yield (80%). In addition, compound 1 and its synthesis product (5) show moderate and non-selective cytotoxic activities against four cancer cells, KB (a human epidermal carcinoma), MCF7 (human breast carcinoma), SK-LU-1 (human lung carcinoma) and HepG2 (hepatocellular carcinoma).
Faculty of Chemistry, Hanoi University of Education, 136 Xuan Thuy Road, Cau Giay, Hanoi, Vietnam.
Pham Huu
PH
Dien
Nguyen Thi
NT
Nhan
Hoang Thi
HT
Le Thuy
Dang Ngoc
DN
Quang
D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D031048:Cnidium / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology; D011564:Furocoumarins / Q000737:chemistry / Q000494:pharmacology; D056945:Hep G2 Cells; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry*; D012855:Sitosterols / Q000737:chemistry / Q000494:pharmacology
D003374:Coumarins; D011564:Furocoumarins; D010936:Plant Extracts; D012855:Sitosterols; C031534:imperatorin; C011015:lyoniside; C046627:osthol