Highly diastereoselective synthesis of 1-pyrrolines via SnCl4-promoted [3 + 2] cycloaddition between activated donor-acceptor cyclopropanes and nitriles.
Activated donor-acceptor cyclopropanes underwent formal [3 + 2] cycloaddition with nitriles in the presence of SnCl(4). The product 1-pyrrolines were isolated as single cis-diastereomers in moderate to good yields.
School of Chemistry, Bharathidasan University, Tiruchirappalli-620 024, Tamil Nadu, India.
Gopal
G
Sathishkannan
Kannupal
K
Srinivasan