TBHP-mediated oxidative thiolation of an sp3 C-H bond adjacent to a nitrogen atom in an amide.
The first example of molecular sieve-promoted TBHP-mediated direct oxidative thiolation of an sp(3) C-H bond adjacent to a nitrogen atom with disulfides under metal-free conditions, which allows for preparation of numerous S,N-containing compounds, is presented. Moreover, diverse benzothiazoles and a fipronil analog can be synthesized through this strategy.
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
Ri-Yuan
RY
Tang
Ye-Xiang
YX
Xie
Yi-Li
YL
Xie
Jian-Nan
JN
Xiang
Jin-Heng
JH
Li