[Fibroblast growth factor-23 (FGF-23). Part II. Significance in chronic kidney disease].
Fibroblast growth factor-23 (FGF-23) is a phosphatonine of important value in maintenance of mineral homeostasis. In the 1st part of this review dealing with FGF-23 its composition, mode of action, and regulatory mechanisms of its secretion were described. In the 2nd part of this work, regulatory activity in the calcium-phosphate homeostasis in different stages of chronic kidney disease (CKD) with special attention to increased synthesis of FGF-23 in the course of declined glomerular filtration rate were elucidated. The FGF-23 concentration in dialyzed patients, subjects after parathyroidectomy and patients after kidney transplantation were characterized. The relationship between FGF-23 serum concentaration and cardiovascular morbidity and mortality will be presented in the 3rd part of this review.
Katedra i Klinika Nefrologii, Uniwersytet Jagielloński, Collegium Medicum w Krakowie.
Danuta
D
Fedak
Katarzyna
K
Bigaj
Władysław
W
Sułowicz
D015415:Biomarkers / Q000378:metabolism; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000096:biosynthesis*; D005919:Glomerular Filtration Rate; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000628:therapy*; D016030:Kidney Transplantation / Q000502:physiology; D016105:Parathyroidectomy; D006435:Renal Dialysis
D015415:Biomarkers; C000717427:FGF23 protein, human; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23