Association between indices of body mass and antibody titers to heat-shock protein-27 in healthy subjects.
OBJECTIVE
We have assessed the relationship between indices of adiposity and antibody titers to Hsp-27 in healthy subjects.


METHODS
Two-hundred and fifty subjects were studied, including 50 normal-weight subjects (body-mass-index (BMI) 25 kg/m(2)), 100 overweight subjects (BMI 25 to 30 kg/m(2)) (n=100) and 100 obese subjects (BMI ≥ 30 kg/m(2)).


RESULTS
Anti-Hsp27-antibody levels in obese subjects were [0.34 (0.20-0.39) absorbency unit], being significantly higher than overweight and normal-weight groups (P<0.05). Anti-Hsp27-antibody levels in overweight subjects [0.29 (0.15-0.34) absorbency unit] were statistically higher than controls [0.18 (0.10-0.23) absorbency unit] (P<0.05).


CONCLUSIONS
High anti-Hsp-27-antibody levels in obese-subjects without established coronary disease may be related to a heightened state of immunoactivation associated with obesity.
Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
Shima
S
Tavallaie
Amir Ali
AA
Rahsepar
Hamid
H
Abdi
Mohsen
M
Moohebati
Fatemeh
F
Moodi
Hossein
H
Pourghadamyari
Habibollah
H
Esmaily
Fatemeh
F
Khorashadizadeh
Majid
M
Ghayour-Mobarhan
Gordon A A
GA
Ferns
D000042:Absorption; D050154:Adiposity; D000293:Adolescent; D000328:Adult; D000886:Anthropometry / Q000379:methods; D015992:Body Mass Index; D001835:Body Weight; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D055551:HSP27 Heat-Shock Proteins / Q000737:chemistry* / Q000276:immunology; D006360:Heat-Shock Proteins; D006801:Humans; D008297:Male; D008875:Middle Aged; D018832:Molecular Chaperones; D009765:Obesity / Q000097:blood; D012044:Regression Analysis
D008078:Cholesterol, LDL; D055551:HSP27 Heat-Shock Proteins; C057725:HSPB1 protein, human; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones