Chemotherapy-induced iatrogenic injury of skin: new drugs and new concepts.
Chemotherapy and its cutaneous side effects are an increasingly common source of iatrogenic injury to the skin, hair, and nails. Cutaneous changes are among the most common side effects from treatment with particular targeted chemotherapeutic agents, especially those that target the epidermal growth factor receptor and small molecule multikinase inhibitors. Less common, but growing in recognition, are the development of secondary cutaneous neoplasms and subacute cutaneous lupus erythematosus as a result of chemotherapy. There is considerable overlap of the multiple entities described as a side effect from conventional chemotherapeutic agents; therefore, the term "toxic erythema of chemotherapy" can be used as an easily understood name.
Department of Dermatology, Yale University School of Medicine, LMP 5040, New Haven, CT 06510, USA. jennifer.choi@yale.edu
Jennifer Nam
JN
Choi
D000970:Antineoplastic Agents / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology; D004890:Erythema / Q000139:chemically induced; D005148:Facial Dermatoses / Q000139:chemically induced; D005533:Foot Dermatoses / Q000139:chemically induced; D006197:Hair / Q000187:drug effects; D006801:Humans; D007049:Iatrogenic Disease / Q000453:epidemiology* / Q000517:prevention & control; D007868:Leg Dermatoses / Q000139:chemically induced; D008178:Lupus Erythematosus, Cutaneous / Q000139:chemically induced; D009262:Nails / Q000187:drug effects / Q000293:injuries; D009369:Neoplasms / Q000188:drug therapy; D016032:Randomized Controlled Trials as Topic; D012867:Skin / Q000187:drug effects*; D012871:Skin Diseases / Q000139:chemically induced* / Q000517:prevention & control; D012878:Skin Neoplasms / Q000139:chemically induced; D009626:Terminology as Topic
D000970:Antineoplastic Agents