Risk of stroke following diagnosis with pyogenic liver abscess: a nationwide population-based study.
OBJECTIVE
In the recent years, the mortality rates attributed to pyogenic liver abscess (PLA) have decreased substantially on account of advancements in antibiotics and surgical techniques. It is thus important to better understand the risks associated with the increased number of survivors. This population-based study was designed to estimate the risk of stroke during a 1 year period following diagnosis with PLA, compared to individuals who did not suffer from PLA.


METHODS
Data were obtained from the Taiwan National Health Insurance Research Database. A total of 9,977 patients receiving ambulatory with a diagnosis of PLA were included, together with 49,885 non-PLA patients as our comparison group. Each individual was followed for 1 year, with check-ups at 30 days, 90 days, and 1 year post diagnosis to identify the subsequent occurrence of stroke. Cox proportional hazards regressions were performed for the analysis.


RESULTS
During the 1 year follow-up period, 475 (4.76%) strokes occurred among the PLA patients and 1,713 (3.43%) patients in the non-PLA comparison cohort. The diagnosis of PLA was independently associated with 1.99 (95% confidence interval (CI) 1.68-2.34), 1.72 (95% CI 1.52-1.97), and 1.43 (95% CI 1.28-1.59) times greater risks of stroke during the 30 days, 90 days, and 1 year follow-up periods, respectively, after adjusting for urbanization level, geographic region, monthly income, hypertension, diabetes, coronary heart diseases, renal diseases, heart failure, hyperlipidemia, atrial fibrillation, obesity, and alcohol abuse/alcohol-dependence syndrome.


CONCLUSIONS
We suggest a need for more intensive medical monitoring following PLA infection, especially during the first few months. However, data regarding smoking were unavailable in our dataset and may have biased our findings.
School of Medical Laboratory Sciences and Biotechnology, Taipei Medical University, Taipei, Taiwan.|Department of Physical Medicine and Rehabilitation, Taipei Medical University Hospital, Taipei, Taiwan.
Joseph J
JJ
Keller
Department of Physical Medicine and Rehabilitation, Taipei Medical University Hospital, Taipei, Taiwan.
Jiunn-Horng
JH
Kang
Department of Neurology, Taipei Medical University Hospital, Taipei, Taiwan.
Jau-Jiuan
JJ
Sheu
School of Health Care Administration, College of Medicine, Taipei Medical University, 250 Wu-Hsing St, Taipei, 110, Taiwan. henry11111@tmu.edu.tw.
Herng-Ching
HC
Lin