[The role of co-inhibitory signals driven by CTLA-4 in immune system].
Key players on the immunosurveillance program, T cells are regulated by their surface receptors such as T-cell receptor (TCR), and costimulatory molecules, optimizing T-cell activation. Some of these costimulatory molecules, such as the cytotoxic T-lymphocyte antigen 4 (CTLA-4), induce inhibitory effects on T cells. By "inhibiting the inhibitor" CTLA-4-blocking monoclonal antibodies represent a novel class of weapons against cancers. To better understand the promising future and the limits of this immunotherapy, this review dissects the molecular inhibitory mechanisms induced by CTLA-4 in T cells.
Inserm U891, Centre de recherche en cancérologie de Marseille, Marseille, France. daniel.olive@inserm.fr
Daniel
D
Olive
Suong
S
le Thi
Luc
L
Xerri
Ivan
I
Hirsch
Jacques A
JA
Nunès
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use; D000938:Antigen-Presenting Cells / Q000276:immunology; D000970:Antineoplastic Agents / Q000276:immunology / Q000627:therapeutic use; D060908:CTLA-4 Antigen / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D061025:Costimulatory and Inhibitory T-Cell Receptors / Q000276:immunology; D006801:Humans; D007167:Immunotherapy; D008213:Lymphocyte Activation / Q000276:immunology*; D051379:Mice; D018345:Mice, Knockout; D018448:Models, Immunological; D015166:Monitoring, Immunologic; D009374:Neoplasms, Experimental / Q000276:immunology / Q000628:therapy; D061166:Peripheral Tolerance / Q000276:immunology*; D011494:Protein Kinases / Q000502:physiology; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D015398:Signal Transduction / Q000502:physiology; D013329:Structure-Activity Relationship; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism
D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D060908:CTLA-4 Antigen; D061025:Costimulatory and Inhibitory T-Cell Receptors; D011494:Protein Kinases