Correlation between serum lactadherin and pulse wave velocity and cardiovascular risk factors in elderly patients with type 2 diabetes mellitus.
OBJECTIVE
This study was carried out with the purpose of investigating the association between serum lactadherin, monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor alpha (TNFα) and carotid-femoral pulse wave velocity (PWV) in elderly patients with type 2 diabetes mellitus (T2DM).


METHODS
A total of 105 subjects including 27 T2DM patients without vascular complications (DM), 28 T2DM patients with vascular complications (DC), 25 elderly healthy volunteers (older) and 25 younger healthy volunteers (younger) were recruited into the study. Carotid-femoral PWV was measured using an automatic device. Serum lactadherin, MCP-1 and TNFα were determined by enzyme linked immunosorbent assay.


RESULTS
PWV and lactadherin, MCP-1 and TNFα were significantly higher in DM and DC groups than those of older and younger groups. PWV and lactadherin were higher in older group than those of younger group. Moreover, lactadherin was significantly correlated with MCP-1, TNFα, PWV, HbA1c and 2 h postprandial blood glucose (P2hBG) (P<0.05). In multivariate regression analysis, the independent determinants of lactadherin were HbA1c, P2hBG and age (P<0.05).


CONCLUSIONS
These findings underscore that lactadherin is correlated with poor blood glucose control and diabetic vascular complications.
Department of Geriatrics, Qi-Lu Hospital of Shandong University, Key Laboratory of Cardiovascular Proteomics of Shandong Province, People's Republic of China.
Mei
M
Cheng
Bao-ying
BY
Li
Xiao-li
XL
Li
Qian
Q
Wang
Jian-hua
JH
Zhang
Xue-jiao
XJ
Jing
Hai-qing
HQ
Gao
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000954:Antigens, Surface / Q000097:blood*; D001783:Blood Flow Velocity / Q000502:physiology; D002339:Carotid Arteries / Q000503:physiopathology*; D018932:Chemokine CCL2 / Q000097:blood; D002681:China; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000097:blood* / Q000503:physiopathology*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008894:Milk Proteins / Q000097:blood*; D011673:Pulsatile Flow / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D000954:Antigens, Surface; D018932:Chemokine CCL2; D006442:Glycated Hemoglobin; D008894:Milk Proteins; D014409:Tumor Necrosis Factor-alpha; C111835:CCL2 protein, human; C098942:MFGE8 protein, human