The use of bone morphogenetic protein 7 in fracture non-unions.
OBJECTIVE
To assess the rate of clinical and radiological union with the use of bone morphogenetic protein 7 (BMP-7) in a range of fractures.


METHODS
This case series retrospectively reviews a series of 16 fracture non-unions in 13 patients. These patients were treated with the commercially available BMP-7. Time to radiological and clinical union was assessed by serial out-patient follow-up.


RESULTS
At nine months post-surgery in which BMP-7 was added, 12 of 16 non-unions had achieved clinical and radiographic union. Three patients required repeat grafting. The mean time to union was 5.1 ± 1.6 months after the application of BMP-7.


CONCLUSIONS
The use of the osteo-inductive agent, BMP-7 results in good clinical and radiological outcomes which are not restricted to tibial non-unions.
Department of Trauma and Orthopaedics, St. Vincent's University Hospital, Elm Park, Dublin, Ireland. svenerwin@hotmail.com
Sven
S
O'hEireamhoin
John F
JF
Quinlan
Kieran O
KO
Rourke
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D055419:Bone Morphogenetic Protein 7 / Q000627:therapeutic use*; D004341:Drug Evaluation / Q000379:methods; D005260:Female; D005264:Femoral Fractures / Q000000981:diagnostic imaging / Q000188:drug therapy; D005500:Follow-Up Studies; D017102:Fracture Healing / Q000187:drug effects; D005599:Fractures, Ununited / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D006810:Humeral Fractures / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012189:Retrospective Studies; D013978:Tibial Fractures / Q000188:drug therapy; D016896:Treatment Outcome
C525819:BMP7 protein, human; D055419:Bone Morphogenetic Protein 7