Quantification of serum fentanyl concentrations from umbilical cord blood during ex utero intrapartum therapy.
Fetal IM injection of fentanyl is frequently performed during ex utero intrapartum therapy (EXIT procedure). We quantified the concentration of fentanyl in umbilical vein blood. Thirteen samples from 13 subjects were analyzed. Medians and ranges are reported as follows. Weight of the newborn at delivery was 3000 g (2020-3715 g). The dose of fentanyl was 60 μg (45-65 μg). The time between IM administration of fentanyl and collection of the sample was 37 minutes (5-86 minutes). Fentanyl was detected in all of the samples, with a median serum concentration of 14.0 ng/mL (4.3-64.0 ng/mL).
Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. trank@email.chop.edu
Kha M
KM
Tran
Lynne G
LG
Maxwell
David E
DE
Cohen
Peter C
PC
Adamson
Vanessa
V
Moll
C Dean
CD
Kurth
Jeffrey L
JL
Galinkin
D000759:Adjuvants, Anesthesia / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics; D001724:Birth Weight; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics; D005312:Fetal Blood / Q000378:metabolism*; D005315:Fetal Diseases / Q000097:blood / Q000601:surgery*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007273:Injections, Intramuscular; D015143:Philadelphia; D011247:Pregnancy
D000759:Adjuvants, Anesthesia; D005283:Fentanyl