Iron metabolism and the innate immune response to infection.
Host antimicrobial mechanisms reduce iron availability to pathogens. Iron proteins influencing the innate immune response include hepcidin, lactoferrin, siderocalin, haptoglobin, hemopexin, Nramp1, ferroportin and the transferrin receptor. Numerous global health threats are influenced by iron status and provide examples of our growing understanding of the connections between infection and iron metabolism.
John Carroll University, Department of Biology, 20700 North Park Boulevard, University Heights, OH 44118, USA.
Erin E
EE
Johnson
Marianne
M
Wessling-Resnick
D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D027682:Cation Transport Proteins / Q000378:metabolism; D006678:HIV / Q000276:immunology / Q000378:metabolism / Q000472:pathogenicity; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D064451:Hepcidins; D006801:Humans; D007113:Immunity, Innate; D007501:Iron / Q000378:metabolism*; D007781:Lactoferrin / Q000378:metabolism; D000071068:Lipocalin-2; D008288:Malaria / Q000276:immunology / Q000378:metabolism / Q000469:parasitology; D009169:Mycobacterium tuberculosis / Q000276:immunology / Q000378:metabolism / Q000472:pathogenicity; D010961:Plasmodium / Q000276:immunology / Q000472:pathogenicity; D014376:Tuberculosis / Q000276:immunology* / Q000382:microbiology; D000098742:Ferroportin; D000099173:Natural Resistance-associated Macrophage Protein 1
D023181:Antimicrobial Cationic Peptides; D002352:Carrier Proteins; D027682:Cation Transport Proteins; D064451:Hepcidins; D007501:Iron; D007781:Lactoferrin; D000071068:Lipocalin-2; D000098742:Ferroportin; D000099173:Natural Resistance-associated Macrophage Protein 1; C578702:HAMP protein, human; C489506:LCN2 protein, human