Synthesis of diaryl ketones via a phosphine-free Fukuyama reaction.
The synthesis of unsymmetrical diaryl ketones via the Fukuyama coupling of thioesters and organozinc reagents is described. Typically, the synthesis of diaryl ketones using this methodology provides low yields. The simple complex, Pd(dba)(2), was found to convert a variety of aryl thioesters to diaryl ketones in good yields.
Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA.
Kamala
K
Kunchithapatham
Chad C
CC
Eichman
James P
JP
Stambuli