[Anti-CTLA-4 monoclonal antibody: a major step in the treatment of metastatic melanoma].
The anti-CTLA-4 Mab ipilimumab is an efficient treatment of metastatic melanoma as a single agent and combined with dacarbazine chemotherapy. The benefit is observed in 10 to 20 % of the patients but it is the only drug to demonstrate an increase in overall survival of patients with metastatic melanoma. The pattern of response is new with delayed and prolonged responses over time. New evaluation criteria have been proposed to evaluate the efficacy of this new therapy. The safety profile is new also with frequent and potentially severe side effects related to the activation of the immune system. The challenges are now to identify biomarkers able to predict ipilimumab benefit and to know how to use ipilimumab in combination with new targeted therapies of melanoma in order to optimize the treatment efficacy.
Institut Gustave Roussy, Villejuif, France. caroline.robert@igr.fr
Caroline
C
Robert
Christine
C
Mateus
D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D000951:Antigens, Neoplasm / Q000276:immunology; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000139:chemically induced; D060908:CTLA-4 Antigen / Q000037:antagonists & inhibitors*; D019496:Cancer Vaccines / Q000627:therapeutic use; D017321:Clinical Trials, Phase I as Topic; D017322:Clinical Trials, Phase II as Topic; D003131:Combined Modality Therapy; D003606:Dacarbazine / Q000627:therapeutic use; D004066:Digestive System Diseases / Q000139:chemically induced; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007167:Immunotherapy; D016233:Immunotherapy, Active; D000074324:Ipilimumab; D008545:Melanoma / Q000188:drug therapy / Q000556:secondary* / Q000628:therapy*; D008546:Melanoma, Experimental / Q000556:secondary / Q000628:therapy; D051379:Mice; D015166:Monitoring, Immunologic; D009422:Nervous System Diseases / Q000139:chemically induced; D022223:Vaccines, Subunit / Q000627:therapeutic use
D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000951:Antigens, Neoplasm; D018906:Antineoplastic Agents, Alkylating; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D019496:Cancer Vaccines; D000074324:Ipilimumab; D022223:Vaccines, Subunit; D003606:Dacarbazine; C520704:tremelimumab