Inter-relationship between different platelet measures of 5-HT and their relationship to aggression in human subjects.
The objective of this study was to explore the inter-relationship of three platelet measures of serotonergic function (5-HT): 5-HT Transporter Binding, 5-HT-2 Receptor Binding and 5-HT Content and to explore their inter-relationship with measures of aggression and impulsivity. 58 male subjects with personality disorder were studied. Numbers of platelet 5-HT Transporter and 5-HT-2 Receptor sites were assessed by examining the Bmax of ³H-Paroxetine Binding and the Bmax of ¹²⁵I-LSD Binding to the blood platelet; 5-HT Content was assessed by measuring the amount of 5-HT in the platelet material. Life history of aggression was assessed by Life History of Aggression. Impulsivity was assessed by the Impulsivity Scale of the Eysenck Personality Questionnaire-II. Platelet 5-HT Transporter Binding correlated with both 5-HT-2 Receptor Binding and 5-HT Content; the latter two variables did not correlate with each other. Only Platelet 5-HT Transporter binding correlated significantly with LHA Aggression. These data suggest that while Platelet 5-HT Transporter binding correlates with both 5-HT-2 Receptor Binding and with 5-HT Content, that only 5-HT Transporter Binding represents a correlate of aggression in male personality disordered subjects.
Clinical Neuroscience & Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL 60637, USA.
Robert
R
Marseille
Royce
R
Lee
Emil F
EF
Coccaro
D000328:Adult; D000374:Aggression / Q000502:physiology*; D001792:Blood Platelets / Q000000981:diagnostic imaging / Q000378:metabolism*; D006801:Humans; D007175:Impulsive Behavior / Q000150:complications / Q000378:metabolism* / Q000523:psychology; D007457:Iodine Radioisotopes / Q000097:blood; D008238:Lysergic Acid Diethylamide; D008297:Male; D017374:Paroxetine; D010554:Personality Disorders / Q000150:complications / Q000378:metabolism* / Q000523:psychology; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D011869:Radioligand Assay / Q000379:methods / Q000523:psychology*; D011877:Radionuclide Imaging; D044348:Receptors, Serotonin, 5-HT2 / Q000032:analysis*; D012701:Serotonin / Q000032:analysis*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000032:analysis*; D014316:Tritium / Q000097:blood
D007457:Iodine Radioisotopes; D044348:Receptors, Serotonin, 5-HT2; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D014316:Tritium; D012701:Serotonin; D017374:Paroxetine; D008238:Lysergic Acid Diethylamide