New labdane diterpenes from Solidago canadensis.
The ethanol extract of roots of Solidago canadensis yielded eight labdane-type diterpenes. Five of those were new natural compounds (9,13,15,16-bisepoxy-labdane-7-ene-6,15-dione (3a), 13-epi-9,13,15,16-bisepoxy-labdane-7-ene-6,15-dione (3b), 15,16-epoxy-labdane-7,13-diene-6,16-dione (5), 15-ethoxy-9,13,15,16-bisepoxy-labdane-7-ene-6-one (6a) and 13-epi-15-ethoxy-9,13,15,16-bisepoxy-labdane-7-ene-6-one (6b). The known labdane diterpenes deoxysolidagenone (1), solidagenone (2) and 15,16-epoxy-labdane-7,13-diene-6,15-dione (4) were also isolated. Chemical structures were determined using 1D and 2D NMR techniques and MS analysis.
Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, Oslo, Norway. helle.wangensteen@farmasi.uio.no
Helle
H
Wangensteen
Thi T
TT
Phan
Frode
F
Rise
Trine G
TG
Halvorsen
Karl E
KE
Malterud
D019659:Asteraceae / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D036624:Solidago / Q000737:chemistry*
D004224:Diterpenes