The incidence and clinical relevance of graft hypertrophy after matrix-based autologous chondrocyte implantation.
BACKGROUND
Graft hypertrophy is the most common complication of periosteal autologous chondrocyte implantation (p-ACI).


OBJECTIVE
The aim of this prospective study was to analyze the development, the incidence rate, and the persistence of graft hypertrophy after matrix-based autologous chondrocyte implantation (mb-ACI) in the knee joint within a 2-year postoperative course.


METHODS
Case series; Level of evidence, 4.


METHODS
Between 2004 and 2007, a total of 41 patients with 44 isolated cartilage defects of the knee were treated with the mb-ACI technique. The mean age of the patients was 35.8 years (standard deviation [SD], 11.3 years), and the mean body mass index was 25.9 (SD, 4.2; range, 19-35.3). The cartilage defects were arthroscopically classified as Outerbridge grades III and IV. The mean area of the cartilage defect measured 6.14 cm(2) (SD, 2.3 cm(2)). Postoperative clinical and magnetic resonance imaging (MRI) examinations were conducted at 3, 6, 12, and 24 months to analyze the incidence and course of the graft.


RESULTS
Graft hypertrophy developed in 25% of the patients treated with mb-ACI within a postoperative course of 1 year; 16% of the patients developed hypertrophy grade 2, and 9% developed hypertrophy grade 1. Graft hypertrophy occurred primarily in the first 12 months and regressed in most cases within 2 years. The International Knee Documentation Committee (IKDC) and visual analog scale (VAS) scores improved during the postoperative follow-up time of 2 years. There was no difference between the clinical results regarding the IKDC and VAS pain scores and the presence of graft hypertrophy.


CONCLUSIONS
The mb-ACI technique does not lead to graft hypertrophy requiring treatment as opposed to classic p-ACI. The frequency of occurrence of graft hypertrophy after p-ACI and mb-ACI is comparable. Graft hypertrophy can be considered as a temporary excessive growth of regenerative cartilage tissue rather than a true graft hypertrophy. It is therefore usually not a persistent or systematic complication in the treatment of circumscribed cartilage defects with mb-ACI.
Department of Orthopaedic Surgery, University Hospital of Munich (LMU), Campus Großhadern, Munich, Germany.
Matthias F
MF
Pietschmann
Thomas R
TR
Niethammer
Annie
A
Horng
Mehmet F
MF
Gülecyüz
Isa
I
Feist-Pagenstert
Volkmar
V
Jansson
Peter E
PE
Müller
D000328:Adult; D001182:Arthroscopy; D002358:Cartilage, Articular / Q000293:injuries* / Q000601:surgery*; D019902:Chondrocytes / Q000637:transplantation*; D005260:Female; D006801:Humans; D006984:Hypertrophy; D015994:Incidence; D007718:Knee Injuries / Q000601:surgery*; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008297:Male; D010521:Periosteum / Q000473:pathology / Q000601:surgery; D011183:Postoperative Complications / Q000453:epidemiology*; D011446:Prospective Studies; D012307:Risk Factors; D018709:Statistics, Nonparametric; D014182:Transplantation, Autologous; D016896:Treatment Outcome