Atacamycins A-C, 22-membered antitumor macrolactones produced by Streptomyces sp. C38.
Three new 22-membered macrolactone antibiotics, atacamycins A-C, were produced by Streptomyces sp. C38, a strain isolated from a hyper-arid soil collected from the Atacama Desert in the north of Chile. The metabolites were discovered in our HPLC-diode array screening and isolated from the mycelium by extraction and chromatographic purification steps. The structures were determined by mass spectrometry and NMR experiments. Atacamycins A, B and C exhibited moderate inhibitory activities against the enzyme phosphodiesterase (PDE-4B2), whereas atacamycin A showed a moderate antiproliferative activity against adeno carcinoma and breast carcinoma cells.
Institut für Chemie, Technische Universität Berlin, Berlin, Germany.
Jonny
J
Nachtigall
Andreas
A
Kulik
Soleiman
S
Helaly
Alan T
AT
Bull
Michael
M
Goodfellow
Juan A
JA
Asenjo
Armin
A
Maier
Jutta
J
Wiese
Johannes F
JF
Imhoff
Roderich D
RD
Süssmuth
Hans-Peter
HP
Fiedler
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002677:Chile; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4 / Q000378:metabolism; D003889:Desert Climate; D004354:Drug Screening Assays, Antitumor; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D025282:Mycelium / Q000737:chemistry; D019906:Nuclear Magnetic Resonance, Biomolecular; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism* / Q000494:pharmacology; D012988:Soil Microbiology; D021241:Spectrometry, Mass, Electrospray Ionization; D017550:Spectroscopy, Fourier Transform Infrared; D013302:Streptomyces / Q000737:chemistry / Q000378:metabolism*
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D061065:Polyketides; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; C517360:PDE4B protein, human