Preparation and properties of nanosized biodegradable polymer capsules.
This article reports the preparation and properties of nanosized biodegradable polymer capsules synthesized using the electrocapillary emulsification method. The biodegradable polymers used were poly(ε-caprolactone) (PCL), which is a highly biodegradable and biocompatible polymer, and poly(lactide-co-glycolic acid) (PLGA). While the size of the capsules prepared using PCL alone was in the micrometer range, it decreased with an increase in the amount of PLGA added to PCL and eventually reached the nanometer level. When the electrocapillary emulsification applied potential was 2000 V, the sizes of the capsules (PCL:PLGA = 5:5) ranged from 50 to 80 nm. The percentage of glucose trapped in the PCL/PLGA nanocapsules was higher than 80% and the duration of glucose release from the nanocapsules was about two times longer than that from PCL capsules.
Tokyo University of Science, Japan. hisakai@rs.noda.tus.ac.jp
Hideki
H
Sakai
Ayasa
A
Sekita
Keisuke
K
Tanaka
Kenichi
K
Sakai
Tamotsu
T
Kondo
Masahiko
M
Abe
D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D001673:Biodegradation, Environmental; D004337:Drug Carriers / Q000737:chemistry; D004563:Electrochemistry; D004655:Emulsions; D005947:Glucose / Q000737:chemistry; D019344:Lactic Acid / Q000138:chemical synthesis / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000138:chemical synthesis / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000379:methods*
D001672:Biocompatible Materials; D004337:Drug Carriers; D004655:Emulsions; D053769:Nanocapsules; D011091:Polyesters; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; C016240:polycaprolactone; D011100:Polyglycolic Acid; D019344:Lactic Acid; D005947:Glucose