Glucocorticoid-induced osteoporosis.
Glucocorticoid-induced osteoporosis is one of the most important side-effects of glucocorticoid use, leading to an increased fracture risk. In this review, recent advances in the understanding of the mechanisms of glucocorticoid-induced osteoporosis are summarised. Methods to identify persons at risk for fractures are discussed, as well as the new ACR recommendations for the prevention and treatment of glucocorticoid-induced osteoporosis (2010). Different treatment options are summarised considering the pathogenesis of glucocorticoid-induced osteoporosis. Improved insights into pathogenesis might result in development of new treatment possibilities.
VU University Medical Center, Department of Rheumatology, 1081 HV Amsterdam, The Netherlands. d.denuyl@vumc.nl
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D
den Uyl
I E M
IE
Bultink
W F
WF
Lems
D050723:Fractures, Bone / Q000453:epidemiology*; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D010024:Osteoporosis / Q000139:chemically induced* / Q000453:epidemiology*; D012307:Risk Factors
D005938:Glucocorticoids