Multiple human papillomavirus-16 associated digital squamous-cell carcinomas in an immunocompetent woman with prior human papillomavirus-related genital carcinoma.
High-risk subtype human papillomavirus (HPV) infection, which is known to contribute to the oncogenesis of anogenital squamous-cell carcinoma (SCC), is detected in the majority of digital SCCs. Evidence suggests a genital-digital route of transmission of high-risk HPV, and most HPV-related digital SCCs occur near the nail unit in immunocompetent adults. As early HPV-related SCC commonly appears as a verrucous periungual papule, a biopsy should be considered if such a lesion persists or occurs in an individual who is likely to inoculate their digits with high-risk HPV from digital-genital contact with themselves or sexual partners. We present a 60-year-old woman, who has a personal history of vulvar and cervical SCC and an appreciable disease burden from SCCs that involved five digits of her hands.
Department of Dermatology, New York University, New York, New York, USA.
Raegan
R
Hunt
Charlotte
C
Hwa
Julia
J
Tzu
Rishi
R
Patel
Stephen K
SK
Tyring
Jennifer
J
Stein
D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000821:virology*; D003218:Condylomata Acuminata / Q000821:virology; D005260:Female; D005385:Fingers / Q000473:pathology / Q000821:virology; D052162:Human papillomavirus 16 / Q000302:isolation & purification*; D006801:Humans; D007121:Immunocompetence; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000473:pathology / Q000821:virology*; D030361:Papillomavirus Infections / Q000473:pathology / Q000821:virology*; D012747:Sexual Partners; D012878:Skin Neoplasms / Q000473:pathology / Q000821:virology*; D002583:Uterine Cervical Neoplasms / Q000821:virology*; D014846:Vulvar Neoplasms / Q000821:virology*