Peripheral oxidative damage in early-stage mood disorders: a nested population-based case-control study.
Systemic toxicity is a relevant dimension of pathophysiology in bipolar disorder, and oxidative damage is one potential link between central and peripheral pathology. Although there is mounting evidence that chronic bipolar disorder is associated with oxidative stress, studies in the early stages of bipolar disorder are scarce, and heavily reliant on clinical in lieu of population studies. The objective of this study was to confirm leading hypotheses about the role of oxidative damage in bipolar disorder. To that end, we nested a case-control study in a population-based study of young adults aged 18-24 yr. After an initial psychopathology screen, all people with a lifetime history of (hypo)mania and matched controls underwent a structured diagnostic interview. This yielded a sample of 231 participants, in whom we measured serum protein carbonyl content (PCC) and thiobarbituric acid reactive substances (TBARS). People with bipolar disorder had higher PCC levels than healthy subjects. Those with major depression were not different from control subjects in either PCC or TBARS levels. Both bipolar disorder and major depression were associated with higher PCC levels in the a priori regression model controlling for possible confounders. These findings indicate that protein oxidative damage is present from early stages and can be seen as a sign of early illness activity in mood disorders.
National Institute for Translational Medicine, Hospital de Clínicas de Porto Alegre-HCPA, Porto Alegre, Brazil.
Pedro V S
PV
Magalhães
Karen
K
Jansen
Ricardo Tavares
RT
Pinheiro
Gabriela Delevati
GD
Colpo
Leonardo Lisbôa
LL
da Motta
Fábio
F
Klamt
Ricardo Azevedo
RA
da Silva
Flávio
F
Kapczinski
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D018672:Community Health Planning; D005260:Female; D006801:Humans; D008297:Male; D019964:Mood Disorders / Q000378:metabolism* / Q000503:physiopathology*; D018384:Oxidative Stress / Q000502:physiology*; D050050:Protein Carbonylation / Q000502:physiology; D011569:Psychiatric Status Rating Scales; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D055815:Young Adult
D017392:Thiobarbituric Acid Reactive Substances