Association of -619C/T polymorphism in CDSN gene and  psoriasis risk: a meta-analysis.
Previous studies investigating the association between  corneodesmosin (CDSN) polymorphisms and psoriasis risk have provided  inconsistent results. The aim of our study was to clarify the effects of CDSN  -619C/T polymorphism on psoriasis risk by conducting a meta-analysis. We  conducted searches of the published literature in Pubmed and Embase databases  up to October 2010. Six studies with a total of 842 psoriasis cases and 981  healthy controls were retrieved. Statistical analysis was performed with the  programs Review Manager (version 5.0.24) and Stata (version 9.2). Meta-analysis  results showed that there was no significant difference in CDSN -619C/T  genotype distribution between psoriasis and control in the comparisons of C  allele vs T allele, CC vs CT + TT, CC + CT vs TT, CC vs TT, and CC vs CT (respectively: OR = 1.28, 95%CI = 0.82-2.00, P =  0.28; OR = 1.33, 95%CI = 0.80-2.21, P = 0.28; OR = 1.23, 95%CI = 0.80-1.91, P =  0.35; OR = 1.41, 95%CI = 0.64-3.12, P = 0.40; OR = 1.30, 95%CI = 0.81-2.06, P =  0.27). In the subgroup analysis by ethnicity, results also showed no  significant association between CDSN -619C/T polymorphism and susceptibility to  psoriasis in both Caucasian and Asian populations. In conclusion, this  meta-analysis suggests that CDSN -619C/T polymorphism may not be associated  with susceptibility to psoriasis.
Department of Dermatology, The First Affiliated Hospital, China Medical University, Shenyang, China.
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D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006023:Glycoproteins / Q000235:genetics*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011565:Psoriasis / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors
C109656:CDSN protein, human; D006023:Glycoproteins; D036341:Intercellular Signaling Peptides and Proteins