Location, location, location: FoxM1 mediates β-catenin nuclear translocation and promotes glioma tumorigenesis.
Genetic alterations in the Wnt/β-catenin/TCF-signaling pathway are commonly found in human tumors, but not in glioblastomas. In this issue of Cancer Cell, Zhang et al. report that FoxM1 mediates β-catenin nuclear translocation in glioblastoma, suggesting a novel mechanism for glioblastoma progression in the absence of conventional Wnt/β-catenin pathway activation.
Department of Developmental Biology, Howard Hughes Medical Institute, Lorry I. Lokey Stem Cell Research Building, Stanford University, School of Medicine, Stanford, CA 94305-5458, USA.
Angela
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Bowman
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Nusse