Fragrance material review on 2-phenyl-2-propanol.
A toxicologic and dermatologic review of 2-phenyl-2-propanol when used as a fragrance ingredient is presented. 2-Phenyl-2-propanol is a member of the fragrance structural group Aryl Alkyl Alcohols and is a tertiary alcohol. The AAAs are a structurally diverse class of fragrance ingredients that includes primary, secondary, and tertiary alkyl alcohols covalently bonded to an aryl (Ar) group, which may be either a substituted or unsubstituted benzene ring. The common structural element for the AAA fragrance ingredients is an alcohol group -C-(R1)(R2)OH and generically the AAA fragrances can be represented as an Ar-C-(R1)(R2)OH or Ar-Alkyl-C-(R1)(R2)OH group. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 2-phenyl-2-propanol were evaluated then summarized and includes physical properties, acute toxicity, skin irritation, skin sensitization, and toxicokinetics data. A safety assessment of the entire Aryl Alkyl Alcohols will be published simultaneously with this document; please refer to Belsito et al. (2012) for an overall assessment of the safe use of this material and all Aryl Alkyl Alcohols in fragrances.
Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA. jscognamiglio@rifm.org
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Jones
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Letizia
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D000818:Animals; D006801:Humans; D010476:Perfume; D020005:Propanols / Q000493:pharmacokinetics / Q000633:toxicity*; D011817:Rabbits; D051381:Rats; D012867:Skin / Q000187:drug effects; D018675:Toxicity Tests
D010476:Perfume; D020005:Propanols; C017623:2-phenyl-2-propanol