Shaping microtubules into diverse patterns: molecular connections for setting up both ends.
Microtubules serve as rails for intracellular trafficking and their appropriate organization is critical for the generation of cell polarity, which is a foundation of cell differentiation, tissue morphogenesis, ontogenesis and the maintenance of homeostasis. The microtubule array is not just a static railway network; it undergoes repeated collapse and reassembly in diverse patterns during cell morphogenesis. In the last decade much progress has been made toward understanding the molecular mechanisms governing complex microtubule patterning. This review first revisits the basic principle of microtubule dynamics, and then provides an overview of how microtubules are arranged in highly shaped and functional patterns in cells changing their morphology by factors controlling the fate of microtubule ends.
Optical Image Analysis Unit, RIKEN Center for Developmental Biology, Kobe Institute, Kobe, Hyogo, Japan. y-kiyosue@cdb.riken.jp
Yuko
Y
Mimori-Kiyosue
D016764:Cell Polarity / Q000502:physiology; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism*; D009024:Morphogenesis; D021381:Protein Transport
D008869:Microtubule-Associated Proteins