Putative canine origin of rotavirus strain detected in a child with diarrhea, Taiwan.
Rotavirus G3P[3] strains have been reported from a variety of species including humans, cats, dogs, monkeys, goats, and cows. Here, we report the characterization of the first human G3P[3] rotavirus from East Asia identified in a 2-year-old child who was treated in a hospital's emergency ward in Taiwan in February 2005. Sequence and phylogenetic analysis demonstrated a close genetic relationship between the VP4, VP6, VP7, and NSP4 genes of Taiwanese G3P[3] strain 04-94s51 and an Italian canine strain isolated a decade ago, suggesting a canine origin for the Taiwanese strain. In contrast, the Taiwanese strain was only moderately related to well-characterized canine-origin human G3P[3] strains Ro1845 and HCR3, suggesting a distinct origin for the rotavirus strain from Taiwan.
Research and Diagnostic Center, Centers for Disease Control, Nan Kang District, 161 Kunyang Street, Taipei, Taiwan. fang@cdc.gov.tw
Fang-Tzy
FT
Wu
Krisztián
K
Bányai
Jen-Shiou
JS
Lin
Ho-Sheng
HS
Wu
Chao Agnes
CA
Hsiung
Yhu-Chering
YC
Huang
Kao-Pin
KP
Hwang
Baoming
B
Jiang
Jon R
JR
Gentsch
D000818:Animals; D002675:Child, Preschool; D003967:Diarrhea / Q000821:virology*; D004283:Dog Diseases / Q000821:virology*; D004285:Dogs; D005243:Feces / Q000821:virology; D005838:Genotype; D006801:Humans; D007558:Italy; D012401:Rotavirus / Q000235:genetics*; D013624:Taiwan; D015047:Zoonoses / Q000821:virology