[Is it possible to survive metabolic acidosis with pH measure below 6.8? A study of two cases of inedible alcohol intoxication].
26 of serious inedible alcohol (ethylene glycol and methanol) intoxications have been observed in Lublin Regional Center of Clinical Toxicology during 2010/2011 (18 mounths). As a result of such intoxications, metabolic acidosis and acute renal failure and other organs injury develop. The writings inform that it is possible to survive a pH spectrum between 6.8 and 7.8, whereas beyond these values protein denaturation and death proceed. The paper presents two cases of intoxication with ethylene glycol and ethylene glycol, methanol together where the lowest pH values in capillary blood were recorded below 6.8. The first case is of a male, 45, who was diagnosed glycol concentration at 283.3 mg/dl, with the lowest pH value obtained in the gasometric examination of capillary blood at 6.712. The other case is of another male, 54, who had probably drunk condenser liquid. Ethylene glycol and methanol's concentration were 535 mg/dl and 37.5 mg/dl correspondingly, whereas the lowest capillary blood pH value was recorded at 6.745. Both men had been addicted to alcohol for many years. The treatment demanded multiple hemodialyses, respiratory therapy, catecholamine intravenous injections as well as intensive pharmacological treatment resulting from multi-organ complications. The intoxication in either case was non-lethal.
Samodzielny Publiczny Szpital Wojewódzki im. Jana Bozego w Lublinie, Regionalny Ośrodek Toksykologii Klinicznej.
Halina
H
Kostek
Anna
A
Kujawa
Jarosław
J
Szponar
Piotr
P
Danielewicz
Magdalena
M
Majewska
Grzegorz
G
Drelich
D000138:Acidosis / Q000097:blood* / Q000139:chemically induced*; D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000628:therapy; D000435:Alcoholic Intoxication / Q000097:blood* / Q000628:therapy*; D002395:Catecholamines / Q000008:administration & dosage; D019855:Ethylene Glycol / Q000097:blood / Q000506:poisoning*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D000432:Methanol / Q000506:poisoning*; D008875:Middle Aged; D006435:Renal Dialysis
D002395:Catecholamines; D019855:Ethylene Glycol; D000432:Methanol