Obionin B: An o-pyranonaphthoquinone decaketide from an unidentified fungus (MSX 63619) from the Order Pleosporales.
A fungal extract (MSX 63619), from the Mycosynthetix library of over 50,000 fungi, displayed promising cytotoxicity against a human tumor cell panel. Bioactivity-directed fractionation led to the isolation of an o-pyranonaphthoquinone decaketide, which we termed obionin B (1). The structure of 1 was deduced via spectroscopic and spectrometric techniques. The IC(50) value of 1 was moderate, ranging from 3 to 13 μM, depending on the cell line tested.
University of North Carolina at Greensboro, Department of Chemistry and Biochemistry, P.O. Box 26170, Greensboro, NC 27402.
Sloan
S
Ayers
Tyler N
TN
Graf
Audrey F
AF
Adcock
David J
DJ
Kroll
Qi
Q
Shen
Steven M
SM
Swanson
Mansukh C
MC
Wani
Blaise A
BA
Darveaux
Cedric J
CJ
Pearce
Nicholas H
NH
Oberlies