Combining two-directional synthesis and tandem reactions: a short formal synthesis of halichlorine.
A short and efficient synthesis of an advanced intermediate (1) in the Clive route to halichlorine has been achieved in 12 steps and 13.2% yield by a combined two-directional synthesis/tandem reaction strategy.
School of Chemistry, University of Nottingham, Nottingham, UK NG7 2RD.
Camille
C
Gignoux
Annabella F
AF
Newton
Alexandre
A
Barthelme
William
W
Lewis
Marie-Lyne
ML
Alcaraz
Robert A
RA
Stockman
D000470:Alkaloids / Q000138:chemical synthesis*; D013141:Spiro Compounds / Q000138:chemical synthesis*
D000470:Alkaloids; D013141:Spiro Compounds; C412666:halichlorine