Cervical human papillomavirus infection in Mexican women with systemic lupus erythematosus or rheumatoid arthritis.
Cervical human papillomavirus (HPV+) infection is associated with an increased risk of cervical dysplasia. Although the frequency of HPV+ in systemic lupus erythematosus (SLE) has been investigated in some races its prevalence in Hispanic women is still unknown. This cross-sectional study evaluated the prevalence of cervical HPV+ in Mexican women with SLE (n = 34) or rheumatoid arthritis (RA) (n = 43) and in healthy controls (n = 146). These women were interviewed about risk factors for sexually transmitted infections and cervical cytology analysis was performed. HPV+ viral types were identified using PCR: HPV+ was observed in 14.7% of SLE, 27.9% of RA and 30.8% of controls. High-risk HPV types were observed in 11.7% of women with SLE, 27.9% of women with RA, and in 26% of the controls. High-risk viral types 58, 35 and 18 were the most frequently identified in SLE. Two women with SLE had a high-grade squamous intraepithelial lesion and one had cervical cancer. An association was observed between methotrexate utilization, longer duration of therapy with prednisone, and HPV+ in RA or SLE. Thus, there is a high prevalence of cervical HPV infection in Mexican women with SLE or RA, and physicians must be vigilant in preventing the development of cervical dysplasia.
Sistema de Educación Media Superior, Preparatoria 17, University of Guadalajara, Guadalajara, Mexico.
W
W
Rojo-Contreras
E M
EM
Olivas-Flores
J I
JI
Gamez-Nava
H
H
Montoya-Fuentes
B
B
Trujillo-Hernandez
X
X
Trujillo
A E
AE
Suarez-Rincon
L M
LM
Baltazar-Rodriguez
J
J
Sanchez-Hernandez
M
M
Ramirez-Flores
J
J
Vazquez-Salcedo
J
J
Rojo-Contreras
J
J
Morales-Romero
L
L
Gonzalez-Lopez
D000328:Adult; D052685:Alphapapillomavirus / Q000235:genetics / Q000302:isolation & purification*; D000704:Analysis of Variance; D001172:Arthritis, Rheumatoid / Q000453:epidemiology*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004279:DNA, Viral / Q000302:isolation & purification; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology*; D008800:Mexico / Q000453:epidemiology; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology; D015995:Prevalence; D015229:Sexually Transmitted Diseases, Viral / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology; D014626:Vaginal Smears
D004279:DNA, Viral