Cyclin beyond the cell cycle: new partners at the synapse.
In this issue of Developmental Cell, Odajima, Wills, and colleagues (2011) demonstrate that the cell-cycle regulator, cyclin E, sequesters Cdk5, a key regulator of neuronal development and synaptic plasticity. This cell-cycle-independent function of cyclin E reveals an exciting mode of Cdk5 regulation in postmitotic neurons and offers a window into evolutionary parsimony.
Indian Institute for Science Education and Research, Pashan Road, Pune 411021, Maharashtra, India.
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