Morphological analysis of tissue reaction caused by a new endodontic paste in subcutaneous tissue of rats.
OBJECTIVE
To assess the biocompatibility of an experimental endodontic paste based on the ethyl acetate fraction of Pothomorphe umbellata + calcium hydroxide, using propylene glycol as vehicle, in connective tissue of rats.


METHODS
Fifteen rats had four polyethylene tubes implanted in their backs, with each one containing the experimental paste. The tube side was considered the control group. After 7, 21, and 42 days, animals were euthanized.


RESULTS
Intense inflammatory reaction was noticed after 7 days for experimental paste and it was moderate for control group. At 21 days, the inflammatory reaction was moderate for experimental paste and discrete for control group; and at 42 days, it was discrete for experimental paste and control group. Statistical analysis (Dunn's test, P < 0.01) demonstrated significant difference between the fibrous capsule area at 7 and 42 days (P > 0.01) for experimental paste.


CONCLUSIONS
Experimental endodontic paste presented satisfactory tissue reaction in the connective tissue of rats.
Department of Endodontics, School of Dentistry, Federal University of Amazonas, Manaus, AM, Brazil.
André Af
AA
Marques
Emilio C
EC
Sponchiado
Lucas Fr
LF
Garcia
Angela Db
AD
Garrido
Suzelei C
SC
França
Raphael Cc
RC
Lia