High-performance liquid chromatographic separation of position isomers using metal-organic framework MIL-53(Al) as the stationary phase.
Metal-organic framework MIL-53(Al) was explored as the stationary phase for high-performance liquid chromatographic separation of position isomers using a binary and/or polar mobile phase. Baseline separations of xylene, dichlorobenzene, chlorotoluene and nitrophenol isomers were achieved on the slurry-packed MIL-53(Al) column with high resolution and good precision. The effects of mobile phase composition, injected sample mass and temperature were investigated. The separation of xylene, dichlorobenzene, chlorotoluene and nitrophenol isomers on MIL-53(Al) were controlled by entropy change.
State Key Laboratory of Medicinal Chemical Biology, and Research Center for Analytical Sciences, College of Chemistry, Nankai University, Tianjin 300071, China.
Cheng-Xiong
CX
Yang
Shan-Shan
SS
Liu
He-Fang
HF
Wang
Shan-Wei
SW
Wang
Xiu-Ping
XP
Yan
D000535:Aluminum / Q000737:chemistry*; D002722:Chlorobenzenes / Q000737:chemistry / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D007536:Isomerism; D009596:Nitrophenols / Q000737:chemistry / Q000302:isolation & purification; D009930:Organic Chemicals / Q000737:chemistry / Q000302:isolation & purification*; D009942:Organometallic Compounds / Q000737:chemistry*; D013696:Temperature; D014050:Toluene / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification; D014992:Xylenes / Q000737:chemistry / Q000302:isolation & purification
D002722:Chlorobenzenes; D009596:Nitrophenols; D009930:Organic Chemicals; D009942:Organometallic Compounds; D014992:Xylenes; D014050:Toluene; D000535:Aluminum