canSAR: an integrated cancer public translational research and drug discovery resource.
canSAR is a fully integrated cancer research and drug discovery resource developed to utilize the growing publicly available biological annotation, chemical screening, RNA interference screening, expression, amplification and 3D structural data. Scientists can, in a single place, rapidly identify biological annotation of a target, its structural characterization, expression levels and protein interaction data, as well as suitable cell lines for experiments, potential tool compounds and similarity to known drug targets. canSAR has, from the outset, been completely use-case driven which has dramatically influenced the design of the back-end and the functionality provided through the interfaces. The Web interface at http://cansar.icr.ac.uk provides flexible, multipoint entry into canSAR. This allows easy access to the multidisciplinary data within, including target and compound synopses, bioactivity views and expert tools for chemogenomic, expression and protein interaction network data.
Cancer Research UK Cancer Therapeutics Unit, Institute of Cancer Research, Haddow Laboratories, Belmont, Surrey SM2 5NG, UK.
Mark D
MD
Halling-Brown
Krishna C
KC
Bulusu
Mishal
M
Patel
Joe E
JE
Tym
Bissan
B
Al-Lazikani
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D030541:Databases, Genetic; D055808:Drug Discovery; D015870:Gene Expression; D014644:Genetic Variation; D006801:Humans; D020407:Internet; D008958:Models, Molecular; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism*; D060066:Protein Interaction Maps; D034622:RNA Interference; D018511:Systems Integration; D057170:Translational Research, Biomedical
D000970:Antineoplastic Agents