Dual face apoptotic machinery: from initiator of apoptosis to guardian of necroptosis.
In this issue of Immunity, Bonnet et al. (2011) show that skin-specific ablation of the adaptor protein FADD sensitizes keratinocytes to RIPK3-dependent necrotic cell death, which leads to severe skin inflammation.
Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, B-9052 Ghent, Belgium.
Wim
W
Declercq
Nozomi
N
Takahashi
Peter
P
Vandenabeele