Polydisulfide manganese(II) complexes as non-gadolinium biodegradable macromolecular MRI contrast agents.
OBJECTIVE
To develop safe and effective manganese(II) -based biodegradable macromolecular MRI contrast agents.


METHODS
In this study, we synthesized and characterized two polydisulfide manganese(II) complexes, Mn-DTPA cystamine copolymers and Mn-EDTA cystamine copolymers, as new biodegradable macromolecular MRI contrast agents. The contrast enhancement of the two manganese-based contrast agents were evaluated in mice bearing MDA-MB-231 human breast carcinoma xenografts, in comparison with MnCl(2) .


RESULTS
The T(1) and T(2) relaxivities were 4.74 and 10.38 mM(-1) s(-1) per manganese at 3T for Mn-DTPA cystamine copolymers (M(n) = 30.50 kDa) and 6.41 and 9.72 mM(-1) s(-1) for Mn-EDTA cystamine copolymers (M(n) = 61.80 kDa). Both polydisulfide Mn(II) complexes showed significant liver, myocardium and tumor enhancement.


CONCLUSIONS
The manganese-based polydisulfide contrast agents have a potential to be developed as alternative non-gadolinium contrast agents for MR cancer and myocardium imaging.
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Zhen
Z
Ye
Eun-Kee
EK
Jeong
Xueming
X
Wu
Mingqian
M
Tan
Shouyu
S
Yin
Zheng-Rong
ZR
Lu
D000818:Animals; D003287:Contrast Media / Q000138:chemical synthesis*; D004220:Disulfides / Q000737:chemistry*; D004492:Edetic Acid / Q000737:chemistry*; D005260:Female; D006801:Humans; D046911:Macromolecular Substances / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D008325:Mammary Neoplasms, Experimental / Q000175:diagnosis*; D017895:Manganese Compounds / Q000138:chemical synthesis*; D051379:Mice; D008819:Mice, Nude; D004369:Pentetic Acid / Q000138:chemical synthesis*; D014183:Transplantation, Heterologous
D003287:Contrast Media; D004220:Disulfides; D046911:Macromolecular Substances; D017895:Manganese Compounds; D004369:Pentetic Acid; D004492:Edetic Acid