Biomarkers of age effect on renal function in Down syndrome.
OBJECTIVE
To assess differences in kidney function between Down syndrome (DS) individuals and a control group related to aging.


METHODS
Creatinine (Cr) and specific gravity (SG) were assessed by spectrophotometric and refractometric assays in urine samples of 103 individuals with DS and 82 age-matched controls.


RESULTS
Significantly lower levels of Cr and SG were found in DS after puberty. Significant correlations were found between SG and age as well as between Cr and SG in DS and controls (p ≤ 0.05).


CONCLUSIONS
Premature aging in kidneys of DS patients could lead to an impaired renal function.
Departamento de Medicina Celular y Molecular, Centro de Investigaciones Biológicas (CSIC), Madrid, Spain.
Rodrigo
R
Guzmán
Carlos
C
Campos
Encarnación
E
López-Fernández
Angela
A
Casado
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000032:analysis*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000652:urine; D004314:Down Syndrome / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007223:Infant; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
D015415:Biomarkers; D003404:Creatinine