[Optimization of the matrix formulation of compound Die Da Zhen Tong cataplasm by uniform design].
OBJECTIVE
To optimize the matrix formulation of compound Die Da Zhen Tong cataplasm.


METHODS
The optimal preparation was selected by U17 (17(16)) uniform design, independent variables were the percentage ratio of the matrix formulation component part in compound Die Da Zhen Tong cataplasm,and the viscosity, continued viscosity and overall desirability used as indexes were dependent variables.


RESULTS
The percentage of the matrix formulation component part in compound Die Da Zhen Tong cataplasm was, NP-700: carbomer 980: PVP K-90: dihydroxy aluminum: tartaric: kaolinite: sorbitol: glycerin = 5: 1. 2: 2.5: 0.25: 0.15:4: 12: 5.


CONCLUSIONS
The optimized cataplasm has good viscosity, continued viscosity and high overall desirability.
Guangdong Pharmaceutical University, Guangzhou 510006, China. jxzh1998282@yahoo.com.cn
Ji-xing
JX
Zhang
Jian-ping
JP
Wang
Feng
F
Zhu
Zi-jie
ZJ
Deng
Cui-wei
CW
Zhao
D000268:Adhesiveness; D000279:Administration, Cutaneous; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry*; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D010946:Plants, Medicinal / Q000737:chemistry*; D011126:Polypropylenes / Q000008:administration & dosage / Q000737:chemistry; D011205:Povidone / Q000008:administration & dosage / Q000737:chemistry; D012044:Regression Analysis; D013644:Tartrates / Q000008:administration & dosage / Q000737:chemistry; D014783:Viscosity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001672:Biocompatible Materials; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D011126:Polypropylenes; D013644:Tartrates; D011205:Povidone