Interrelationship of Runx2 and estrogen pathway in skeletal tissues.
Two key molecules in skeletal tissues are bone formation master transcription factor Runx2 and the steroid hormone estrogen. It is well known that these two molecules play pivotal roles in bone homeostasis; however, the functional interaction between Runx2 and estrogen synthesis in skeletal tissues is largely unknown. Recent studies have indicated that there is a positive relationship between Runx2 and the estrogen biosynthesis pathway. In this review, a possible functional link between Runx2 and estrogen synthesis pathway in skeletal tissues will be discusses as well as the biological significance of this interaction.
Department of Biochemistry and Cell Biology, School of Medicine, WCU Program, Kyungpook National University, Daegu, Korea.
Jae-Hwan
JH
Jeong
Je-Yong
JY
Choi
D001141:Aromatase / Q000235:genetics / Q000378:metabolism; D001842:Bone and Bones / Q000166:cytology / Q000378:metabolism*; D050659:Core Binding Factor Alpha 1 Subunit / Q000378:metabolism*; D004967:Estrogens / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
D050659:Core Binding Factor Alpha 1 Subunit; D004967:Estrogens; D001141:Aromatase