[Impact of ECMO on drugs pharmacokinetics].
Extracorporeal membrane oxygenation (ECMO) is a life support system used in the treatment of patients of all ages with severe respiratory or cardiorespiratory failure.            Despite the intensive use of drugs in the treatment of patients on ECMO, few studies have been conducted to determine the impact of this device on the pharmacokinetics of drugs.            Publications in this field have shown pharmacokinetics changes resulting in an increase in volume of distribution of drugs and/or decreased clearance with consequent increase of their half-life.            Reduced plasma concentrations of some drugs due to their adsorption on the different components of the circuit further complicates the determination of pharmacokinetic parameters of patients treated by ECMO.            The literature published up to now on the pharmacokinetic changes associated with ECMO provide preliminary support for dosage adjustment. However, more research is needed to identify dosage strategies for this patient population.
Service Pharmacie, Groupe Hospitalier Pitié-Salpêtrière, AP-HP, Paris, France.
Nesrine
N
Hasni
Florian
F
Lemaitre
Christine
C
Fernandez
Alain
A
Combes
Robert
R
Farinotti
D000042:Absorption; D015199:Extracorporeal Membrane Oxygenation / Q000009:adverse effects; D006207:Half-Life; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism; D010599:Pharmacokinetics
D004364:Pharmaceutical Preparations