Supramolecular hydrogelators of N-terminated dipeptides selectively inhibit cancer cells.
Consisting of N-terminated diphenylalanine, a new type of supramolecular hydrogelators forms hydrogels within a narrow pH window (pH 5.0 to 6.0) and selectively inhibits growth of HeLa cells, which provides important and useful insights for designing molecular nanofibers as potential nanomedicines.
Department of Chemistry, Brandeis University, 415 South St., Waltham, MA 02454, USA.
Yi
Y
Kuang
Yuan
Y
Gao
Bing
B
Xu
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004151:Dipeptides; D006367:HeLa Cells; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008958:Models, Molecular; D008968:Molecular Conformation; D050997:Nanomedicine; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
D000970:Antineoplastic Agents; D004151:Dipeptides; D020100:Hydrogels; C026650:phenylalanylphenylalanine; D010649:Phenylalanine