Simulation of the temperature increase in human cadaver retina during direct illumination by 150-kHz femtosecond laser pulses.
We have developed a two-dimensional computer model to predict the temperature increase of the retina during femtosecond corneal laser flap cutting. Simulating a typical clinical setting for 150-kHz iFS advanced femtosecond laser (0.8- to 1-μJ laser pulse energy and 15-s procedure time at a laser wavelength of 1053 nm), the temperature increase is 0.2°C. Calculated temperature profiles show good agreement with data obtained from ex vivo experiments using human cadaver retina. Simulation results obtained for different commercial femtosecond lasers indicate that during the laser in situ keratomileusis procedure the temperature increase of the retina is insufficient to induce damage.
University of California, Irvine, Department of Ophthalmology, Irvine, California 92697, USA.
Hui
H
Sun
Nora
N
Hosszufalusi
Eric R
ER
Mikula
Tibor
T
Juhasz
D002102:Cadaver; D003198:Computer Simulation; D020342:Finite Element Analysis; D006358:Hot Temperature / Q000009:adverse effects; D006801:Humans; D066298:In Vitro Techniques; D020731:Keratomileusis, Laser In Situ / Q000009:adverse effects*; D008954:Models, Biological; D055620:Optical Phenomena; D012160:Retina / Q000293:injuries* / Q000502:physiology / Q000528:radiation effects; D013696:Temperature; D013997:Time Factors