Dietary fatty acids linking postprandial metabolic response and chronic diseases.
Chronic diseases are by far one of the main causes of mortality in the world. One of the current global recommendations to counteract disability and premature death resulting from chronic diseases is to decrease the consumption of energy-dense high-fat diets, particularly those rich in saturated fatty acids (SFA). The most effective replacement for SFA in terms of risk factor outcomes for chronic disease are polyunsaturated fatty acids (PUFA) and monounsaturated fatty acids (MUFA). The biochemical basis for healthy benefits of such a dietary pattern has been widely evaluated under fasting conditions. However, the increasing amount of data available from multiple studies suggest that the postprandial state, i.e., "the period that comprises and follows a meal", plays an important, yet underappreciated, role in the genesis of numerous pathological conditions. In this review, the potential of MUFA, PUFA, and SFA to postprandially affect selected metabolic abnormalities related to chronic diseases is discussed.
Laboratory of Cellular and Molecular Nutrition, Instituto de la Grasa (CSIC), 41012 Seville, Spain.
Almudena
A
Ortega
Lourdes M
LM
Varela
Beatriz
B
Bermudez
Sergio
S
Lopez
Rocio
R
Abia
Francisco J G
FJ
Muriana
D000818:Animals; D002908:Chronic Disease / Q000517:prevention & control; D004041:Dietary Fats / Q000009:adverse effects* / Q000378:metabolism; D004194:Disease / Q000209:etiology*; D005227:Fatty Acids / Q000009:adverse effects* / Q000378:metabolism; D006801:Humans; D008660:Metabolism; D019518:Postprandial Period
D004041:Dietary Fats; D005227:Fatty Acids