Expanding the accessible chemical space by solid phase synthesis of bicyclic homodetic peptides.
Norbornapeptides (bicyclo[2.2.1]heptapeptides) and related bicyclic homodetic peptides were prepared by solid-phase peptide synthesis using an orthogonal protection scheme. These conformationally rigid peptides cover an almost pristine area of peptide topological space and adopt globular shapes similar to those of short α-helical peptides.
Department of Chemistry and Biochemistry, University of Berne, Freiestrasse 3, CH-3012 Berne, Switzerland.
Marco
M
Bartoloni
Rameshwar U
RU
Kadam
Julian
J
Schwartz
Julien
J
Furrer
Tamis
T
Darbre
Jean-Louis
JL
Reymond
D000595:Amino Acid Sequence; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry*; D017433:Protein Structure, Secondary; D060327:Solid-Phase Synthesis Techniques / Q000379:methods*
D009842:Oligopeptides