Social cognition impairments in relapsing-remitting multiple sclerosis.
Theory of Mind (ToM) is the ability to attribute independent mental states to self and others to explain and predict behavior. Impairment of ToM is well established in developmental pathologies. In neurological populations, investigation of ToM is still rare but data suggest that ToM impairment could contribute to behavioral and social disturbances. In addition to neurological signs, multiple sclerosis (MS) presents with disorders of cognition and behavior directly related to brain damage. The aim of this study was to assess ToM abilities and recognition of facial emotional expression in adults with MS. We compared 64 patients with relapsing MS and 30 matched healthy controls on three levels of ToM tasks, a facial emotion recognition task, and a neuropsychological assessment. MS patients performed significantly worse than controls in emotion recognition and all ToM tasks (p < .02). These deficits were not correlated with demographic variables or neuropsychological test performance. These findings underscore the importance of assessing ToM and facial recognition in MS, as dysfunction in these areas may impact upon social interaction and, thus, impair quality of life for both patients with MS and their families.
Department of Neurology, Hôpital Maison Blanche, CHRU de Reims, Reims, France.
Audrey
A
Henry
Ayman
A
Tourbah
Marie-Pierre
MP
Chaunu
Lucien
L
Rumbach
Michèle
M
Montreuil
Serge
S
Bakchine
D000328:Adult; D000368:Aged; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000150:complications* / Q000523:psychology*; D009483:Neuropsychological Tests; D057566:Self Report; D012919:Social Behavior; D012938:Social Perception; D018709:Statistics, Nonparametric; D056345:Theory of Mind; D055815:Young Adult