[Reactive oxygen species and 3,4-dihydroxyphenylacetaldehyde in pathogenesis of Parkinson disease].
Reactive oxygen species, which plays a role in pathogenesis of many neurodegenerative diseases, seems to be important also in pathogenesis of the Parkinson's disease. Experiments performed recently, revealed in the cerebrum of patients suffering from this disease (induced by the oxidative stress) elevated levels of 3,4-dihydroxyphenylacetaldehyde (DOPAL)--a strong endogenous neurotoxin to dopamine neurons.
Zakład Biochemii i Fizjologii Klinicznej, Gdańskiego Uniwersytetu Medycznego. iwonar@gumed.edu.pl
Iwona
I
Rybakowska
Grzegorz
G
Szreder
Krystian
K
Kaletha
Małgorzata
M
Barwina
Wojciech
W
Waldman
Jacek
J
Sein Anand
D015102:3,4-Dihydroxyphenylacetic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D006801:Humans; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000209:etiology* / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism
D017382:Reactive Oxygen Species; D015102:3,4-Dihydroxyphenylacetic Acid; C007430:3,4-dihydroxyphenylacetaldehyde