Protective effects of Allium paradoxum against gentamicin-induced nephrotoxicity in mice.
Allium paradoxum (M.Bieb.) G. Don is a locally known vegetable and is utilized for preparation a variety of local foods in northern of Iran. This study was conducted to quantitatively evaluate the recovery effects of A. paradoxum on gentamicin-induced nephrotoxicity in mice. The curative effect of extracts from the aerial parts and bulbs of A. paradoxum against gentamicin-induced renotoxicity in mice was determined. Both extracts at the dose 200 mg kg(-1) day(-1) offered nephroprotective effect by change in the blood urea nitrogen and creatinine. No statistical difference could be obtained in serum creatinine and blood urea nitrogen of bulb-treated mice compared to normal mice. The result show that bulb extract at 200 mg kg(-1) day(-1) has better activity than aerial parts.
National Elites Foundation of Iran, Tehran 14174, Iran. Nabavi208@gmail.com
Seyed Fazel
SF
Nabavi
Seyed Mohammad
SM
Nabavi
Akbar Hajizadeh
AH
Moghaddam
Alireza
A
Naqinezhad
Rata
R
Bigdellou
Sakineh
S
Mohammadzadeh
D000490:Allium / Q000737:chemistry*; D000818:Animals; D004195:Disease Models, Animal; D005839:Gentamicins / Q000633:toxicity*; D006801:Humans; D007674:Kidney Diseases / Q000188:drug therapy* / Q000517:prevention & control*; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage*
D005839:Gentamicins; D010936:Plant Extracts