Evidence-based principles in pathology: existing problem areas and the development of "quality" practice patterns.
BACKGROUND
Contrary to the intuitive impressions of many pathologists, several areas exist in laboratory medicine where evidence-based medicine (EBM) principles are not applied. These include aspects of both anatomic and clinical pathology. Some non-EBM practices are perpetuated by clinical "consumers" of laboratory services because of inadequate education, habit, or overreliance on empirical factors. Other faulty procedures are driven by pathologists themselves.


OBJECTIVE
To consider (1) several selected problem areas representing non-EBM practices in laboratory medicine; such examples include ideas and techniques that concern metastatic malignancies, "targeted" oncologic therapy, general laboratory testing and data utilization, evaluation of selected coagulation defects, administration of blood products, and analysis of hepatic iron-overload syndromes; and (2) EBM principles as methods for remediation of deficiencies in hospital pathology, and implements for the construction of "quality" practices in our specialty.


METHODS
Current English literature relating to evidence-based principles in pathology and laboratory medicine, as well as the authors' experience.


CONCLUSIONS
Evidence-based medicine holds the promise of optimizing laboratory services to produce "quality" practices in pathology. It will also be a key to restraining the overall cost of health care.
Department of Pathology, University Hospital, University of Virginia Health System, Room 3020, 1215 Lee St, Charlottesville, VA 22908-0214, USA. mrw9c@virginia.edu
Mark R
MR
Wick
Alberto M
AM
Marchevsky
D019317:Evidence-Based Medicine; D006801:Humans; D010336:Pathology / Q000592:standards*; D010818:Practice Patterns, Physicians'; D011785:Quality Assurance, Health Care