Kounis syndrome is likely culprit of coronary vasospasm induced by capecitabine.
Capecitabine administration has been associated with various allergic reactions including acneiform skin rash, linchenoid photosensitive eruption, exudative non healing scalp, skin reactions, pyogenic granuloma, subacute cutaneous systemic lupus erythematosus, exudative hyponychia dermatitis, and hand-foot syndrome. A patient who developed ventricular fibrillation following capecitabine-induced coronary vasospasm and necessitating cardioverter-defibrillator implantation was published recently in.
Nicholas G
NG
Kounis
Grigorios G
GG
Tsigkas
George
G
Almpanis
Andreas
A
Mazarakis
D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D003329:Coronary Vasospasm / Q000150:complications*; D003841:Deoxycytidine / Q000031:analogs & derivatives*; D005472:Fluorouracil / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D014693:Ventricular Fibrillation / Q000209:etiology*
D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D005472:Fluorouracil