Surface-enhanced Raman scattering-active nanostructures and strategies for bioassays.
Surface-enhanced Raman scattering (SERS) techniques offer a number of advantages in molecular detection and analysis, particularly in terms of the multiplex detection of biomolecules. So far, many new SERS-based substrates and analytical techniques have been reported. For easy understanding, various SERS techniques are classified into the following four categories: adsorption-mediated direct detection; antibody- or ligand-mediated direct detection; binding catalyzed indirect detection; and tag-based indirect detection. Among these, recent successes of SERS tagging/encoding (nano/micro) materials and detection methods are highlighted, including our recent works. Some novel SERS-based strategies for the detection of several biological molecules are also introduced.
School of Electrical Engineering & Computer Science, Seoul National University, Seoul, 151-742, Republic of Korea.
Bong-Hyun
BH
Jun
Gunsung
G
Kim
Mi Suk
MS
Noh
Homan
H
Kang
Yong-Kweon
YK
Kim
Myung-Haing
MH
Cho
Dae Hong
DH
Jeong
Yoon-Sik
YS
Lee
D001681:Biological Assay / Q000379:methods*; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods; D013059:Spectrum Analysis, Raman / Q000379:methods*