Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following carboplatin-paclitaxel administration in a patient with lung cancer.
A 60-year-old female underwent right upper lobectomy of the lung and lymph node dissection under a diagnosis of cancer in the upper lobe of the right lung. Pathological examination showed stage IIIA adenocarcinoma with mediastinal lymph node metastasis. One month after the operation, adjuvant chemotherapy with carboplatin (CBDCA) and paclitaxel (PTX) was initiated. Four days after the chemotherapy, hyponatremia progressed, and central nervous system disorder developed. A diagnosis of syndrome of inappropriate secretion of antidiuretic hormone (SIADH) was made. She recovered after fluid intake restriction and electrolyte correction. SIADH was considered to be due to the adverse effects of anticancer drugs. In postoperative adjuvant chemotherapy, attention should be paid to the serum Na level.
Division of General Thoracic Surgery, Tottori University Hospital, Yonago, Tottori, Japan. shinji-f-oka@med.tottori-u.ac.jp
S
S
Fujioka
H
H
Nakamura
K
K
Miwa
Y
Y
Taniguchi
T
T
Haruki
Y
Y
Takagi
Y
Y
Yurugi
D000230:Adenocarcinoma / Q000556:secondary; D000077192:Adenocarcinoma of Lung; D000818:Animals; D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D016190:Carboplatin; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000378:metabolism; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced*; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000556:secondary / Q000601:surgery; D008207:Lymphatic Metastasis; D008875:Middle Aged; D017239:Paclitaxel; D014667:Vasopressins / Q000378:metabolism
D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D014667:Vasopressins; D016190:Carboplatin; D017239:Paclitaxel