Combination photodynamic therapy and intravitreal bevacizumab used to treat circumscribed choroidal hemangioma.
Circumscribed choroidal hemagioma (CCH) is an ocular tumor that can result in decreased vision or blindness. Numerous treatment methods have been reported without satisfying results. In recent years, photodynamic therapy (PDT) with verteporfin has been used to treat choroidal hemagioma and resolve the associated exudative retinal detachment, and the results have been inspiring. Here, we report the case of a 36-year-old man with longstanding CCH who suffered from blurred vision for 3 years. He underwent PDT with intravenous infusions of verteporfin, which was a treatment method based on a modified version of the standard macular degeneration PDT protocol, in addition to subsequent intravitreal administrations of bevacizumab as adjuvant therapy for macular edema. Twelve months after treatment, the CCH tumor remained noticeably shrunken, with the complete absorption of the subretinal fluid and the absence of macular edema. In terms of treating subretinal fluid retention, this combination treatment is a safe, effective, and long-lasting therapy for treating established CCH tumors. However, even though the patient's visual field defects improved, the patient's visual acuity remained stable at 6/60 without further improvement. Long-term CCH with prolonged macular edema might have affected the visual prognosis. Patients with CCH still require long-term follow-up examinations after receiving PDT treatments.
Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Chih-Chien
CC
Hsu
Chang-Sue
CS
Yang
Chih-Han
CH
Peng
Fenq-Lih
FL
Lee
Shui-Mei
SM
Lee
D000328:Adult; D020533:Angiogenesis Inhibitors / Q000008:administration & dosage*; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage*; D000068258:Bevacizumab; D002830:Choroid Neoplasms / Q000628:therapy*; D003131:Combined Modality Therapy; D006391:Hemangioma / Q000628:therapy*; D006801:Humans; D058449:Intravitreal Injections; D008297:Male; D010778:Photochemotherapy; D016896:Treatment Outcome
D020533:Angiogenesis Inhibitors; D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab