Enhancement of focused ultrasound with microbubbles on the treatments of anticancer nanodrug in mouse tumors.
Ultrasound sonication with microbubbles (MBs) has the potential to enhance the delivery of nanoparticles into the sonicated tumors. In this study, we investigated the feasibility of focused ultrasound (FUS) sonication with MBs to improve nanodrug delivery and tumor treatment. Tumor-bearing mice were first injected with MBs (SonoVue) intravenously, were then sonicated at the tumors with FUS sonication, and were finally injected with the PEGylated liposomal doxorubicin (DOX). The accumulation of DOX in tumors with time, the tumor growth responses for initial treated tumor size and DOX dosage, and the response for an additional sonication after DOX injection were studied. The results demonstrate that FUS sonication with MBs can significantly enhance DOX accumulation in the sonicated tumor at 24 hours after treatment. A significant hindrance to tumor growth is achieved for a small tumor with a low dose, whereas large tumors require a higher dose.
Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan.
Chung-Yin
CY
Lin
Jia-Rong
JR
Li
Hsiao-Ching
HC
Tseng
Ming-Fang
MF
Wu
Win-Li
WL
Lin
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000528:radiation effects; D045744:Cell Line, Tumor; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004317:Doxorubicin / Q000008:administration & dosage* / Q000528:radiation effects; D004357:Drug Synergism; D005240:Feasibility Studies; D019220:High-Energy Shock Waves; D051379:Mice; D008807:Mice, Inbred BALB C; D045423:Microbubbles; D053769:Nanocapsules / Q000008:administration & dosage* / Q000528:radiation effects*; D010743:Phospholipids / Q000008:administration & dosage / Q000528:radiation effects*; D013010:Sonication / Q000379:methods*; D013459:Sulfur Hexafluoride / Q000008:administration & dosage / Q000528:radiation effects*; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D053769:Nanocapsules; D010743:Phospholipids; C420843:contrast agent BR1; D004317:Doxorubicin; D013459:Sulfur Hexafluoride