Inhibitory Effect of Helicteres gardneriana Ethanol Extract on Acute Inflammation.
The anti-inflammatory effect of an ethanol extract of Helicteres gardneriana (Nees) Castiglioni was assayed in experimental models of pleurisy and microcirculation in situ. Treatment of animals with 500 mg/kg body weight reduced the exudate volume (35% reduction) induced by intrapleural injection of carrageenan and the migration of polymorphonuclear cells into the inflamed pleural cavity of rats (40%). Additionally, rolling and adhesion of leukocytes and the number of leukocytes that migrated toward the perivascular space in response to the carrageenan injection were decreased by the extract (500 mg/kg). These data demonstrate the anti-inflammatory effect of the ethanol extract of Helicteres gardneriana and imply that inhibition of leukocyte-endothelial interactions is important in the extract's mechanism of action.
Laboratory of Inflammation, Department of Pharmacology and Therapeutics, State University of Maringá, Maringá, PR, Brazil.
Juliana Oliveira
JO
de Melo
Laura Lícia Milani
LL
de Arruda
Silmara
S
Baroni
Maria da Conceição Torrado
Mda C
Truiti
Silvana Martins
SM
Caparroz-Assef
Roberto Kenji Nakamura
RK
Cuman
Ciomar Aparecida
CA
Bersani-Amado