Microbiological stability of solutions containing local anesthetics and opioids in closed infusion systems used for epidural analgesia.
Nine solutions containing opiod analgesics and local anesthetics as typically use in epidural catheters were tested for antimicrobial stability. Administration via a pefusor syringe requires several refill processes. It was shown that repetitive refilling of the syringes did not result in any microbiological contamination.
Hospital Pharmacy, University Hospital Jena, Germany.
K
K
Böttcher
W
W
Meissner
B
B
Edel
M
M
Hartmann
D000577:Amides / Q000032:analysis; D000701:Analgesics, Opioid / Q000032:analysis*; D000767:Anesthesia, Epidural; D000779:Anesthetics, Local / Q000032:analysis*; D004339:Drug Compounding; D004340:Drug Contamination; D005283:Fentanyl / Q000032:analysis; D007260:Infusion Pumps; D007262:Infusions, Intravenous; D018710:Pain Clinics; D000077212:Ropivacaine; D012996:Solutions; D013212:Staphylococcus epidermidis; D013594:Syringes
D000577:Amides; D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D012996:Solutions; D000077212:Ropivacaine; D005283:Fentanyl