[Use of postoperative enteral immunonutrition in malnutrition patients with gastrointestinal malignant tumor].
OBJECTIVE
To explore the effects of postoperative enteral immunonutrition on inflammatory response and immunologic function in patients with gastrointestinal tumor.


METHODS
Clinical data of 106 gastrointestinal malignant tumor patients with malnutrition who were treated in the Department of General Surgery, the People's Hospital of Cangzhou in Hebei province from January 2008 to June 2010 were prospectively collected. Patients were randomized into two groups, including enteral immunonutrition group(n=53) and common enteral nutrition group(n=53). Related immunological indices and C-reaction protein were measured on preoperative day 5 and postoperative day 1 and 9.


RESULTS
The general information and preoperative immunological indices were comparable between the two groups(P>0.05). On postoperative day 9, levels of CD4, CD4/CD8, IgG, lymphocyte, NK cells, and complement C3, C4, and CH50 in the enteral immunonutrition group were higher than those in common enteral nutrition group. Serum C-reaction protein level was lower than that in control group, and the difference was statistically significant (P<0.05). Postoperative infection rate was 3.8%(2/53) in enteral immunonutrition group, significantly lower than that in control group with an infection rate of 15.1%(8/53)(P<0.05). The mean postoperative hospital stay of the two groups were (8.1±1.1) d and (9.2±2.1) d, respectively, and the difference was statistically significant(P<0.05).


CONCLUSIONS
For gastrointestinal malignant tumor patients with malnutrition, the use of enteral immunonutrition can alleviate the postoperative trauma and inflammatory response, improve the immune function, thus can reduce the occurrence of postoperative infection, and accelerate patient recovery.
Department of General Surgery, The People's Hospital of Cangzhou, Hebei Cangzhou, China. liujianzhongczsyy@163.com
Jian-zhong
JZ
Liu
Tao
T
Lan
Jin-sheng
JS
Zhang
Hui
H
Chen
Gui-hua
GH
Wang
Jian-lei
JL
Yuan
Qing-sen
QS
Sun
D000293:Adolescent; D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis; D016516:CD4-CD8 Ratio; D003165:Complement System Proteins / Q000276:immunology; D004750:Enteral Nutrition; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000150:complications / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology; D008297:Male; D044342:Malnutrition / Q000150:complications / Q000628:therapy*; D008875:Middle Aged; D011184:Postoperative Period; D011446:Prospective Studies; D016896:Treatment Outcome; D055815:Young Adult
D003165:Complement System Proteins; D002097:C-Reactive Protein