[Experimental model of histamine-induced anaphylactoid reaction on beagle dogs].
OBJECTIVE
To establish animal model of histamine-induced anaphylactoid reactions on Beagle dogs through intravenous injection of histamine phosphate injection.


METHODS
Anaphylactoid reactions was determined according to the changes of praxiology and blood pressure of Beagle dogs after one intravenous injection of histamine phosphate injection.


RESULTS
It showed that typical anaphylactoid reactions be caused by histamine phosphate injection on Beagle dogs, and the response of the high-dose group was more obvious than that of the low-dose group.


CONCLUSIONS
Intravenous injection of histamine phosphate injection could simulate Beagle dogs to bring typical clinical anaphylactoid reaction, that could be used as a sensitive animal model to evaluate anaphylactoid reaction of traditional Chinese medicine injections (TCMIs) in the pre-clinical experiments of both TCMIs and their composition.
Experimental Research Center, China Academy of Chinese Medical Scinces, Beijing 100700, China. zhgw68_8@tom.com
Zhiguo
Z
Wang
Danqiao
D
Wang
Youhua
Y
Yu
Yikui
Y
Li
Yu
Y
Sui
Haifeng
H
Cui
D000707:Anaphylaxis / Q000139:chemically induced*; D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000009:adverse effects; D005260:Female; D006632:Histamine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D007275:Injections, Intravenous; D008297:Male
D004365:Drugs, Chinese Herbal; D006632:Histamine; C027556:histamine phosphate