Synthesis of novel azaspiro[3.4]octanes as multifunctional modules in drug discovery.
Step-economic and scalable syntheses of novel thia-azaspiro[3.4]octanes are reported. These spirocycles and some related intermediates can serve as uncharted multifunctional modules for drug discovery chemistry.
Laboratorium für Organische Chemie, ETH Zürich, CH-8093 Zürich, Switzerland.
Dong Bo
DB
Li
Mark
M
Rogers-Evans
Erick M
EM
Carreira
D001372:Aza Compounds / Q000138:chemical synthesis*; D055808:Drug Discovery; D015394:Molecular Structure; D009795:Octanes / Q000138:chemical synthesis*; D013141:Spiro Compounds / Q000138:chemical synthesis*; D013450:Sulfones / Q000737:chemistry
D001372:Aza Compounds; D009795:Octanes; D013141:Spiro Compounds; D013450:Sulfones