Ethanol induced hepatotoxicity in albino rats.
Twelve male albino rats of 6-8 weeks old, weighing 150-200 gm each were divided into two groups of 6 rats each. Group A was used as control while Group B was given ethanol at a dose of 0.6 ml (0.5 gm)/100 gm/day for 8 weeks. Serum enzymes and liver histology was determined in both groups. Statistically significant increase in the mean enzyme levels, liver weight and volume were observed in the ethanol treated group compared to the controls. Histologically, hepatocytes contained large number of cytoplasmic vacuoles, pyknotic nuclei, and lymphocytic infiltration in treated animals. Ethanol appeared to be hepatotoxic in albino rats.
Department of Anatomy, University of Health Sciences, Lahore.
Muhammad
M
Habib-ur-Rehman
Mohammad
M
Tahir
Khalid P
KP
Lone
Waqas
W
Sami
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000431:Ethanol / Q000009:adverse effects*; D022781:Hepatocytes; D015227:Lipid Peroxidation; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051381:Rats; D005723:gamma-Glutamyltransferase / Q000097:blood
D000431:Ethanol; D005723:gamma-Glutamyltransferase; D000410:Alanine Transaminase