A CMOS image sensor to recognize the cardiovascular disease markers troponin I and C-reactive protein.
A complementary metal oxide semiconductor (CMOS) image sensor was utilized to detect the interaction of cardiovascular disease markers, troponin I and C-reactive protein. Each marker with its respective antibodies was adsorbed to an indium nanoparticle (InNP)-coated glass substrate. Dielectric layers of antigens and antibodies bound onto and interacted on conducting InNPs. Normal room light passed through these protein-layer-bound substrates and hit the CMOS image sensor surface, and the number of photons was detected and converted into digital form. We tested this approach for real-time monitoring of cardiac disease markers based on photon count, demonstrating its low cost and its capacity to detect antigens with high sensitivity at picogram per milliliter concentration.
College of Bionanotechnology, Kyungwon University, Sujeong-Gu, Seongnam-Si, Gyeonggi-Do, Korea.
Jasmine Pramila
JP
Devadhasan
Mohana
M
Marimuthu
Sanghyo
S
Kim
Min-Gon
MG
Kim
D000906:Antibodies / Q000276:immunology; D000937:Antigen-Antibody Reactions; D015415:Biomarkers / Q000032:analysis; D015374:Biosensing Techniques; D002097:C-Reactive Protein / Q000032:analysis* / Q000276:immunology; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000378:metabolism*; D006801:Humans; D007204:Indium / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry; D010087:Oxides / Q000737:chemistry*; D017785:Photons; D012666:Semiconductors; D019210:Troponin I / Q000032:analysis* / Q000276:immunology
D000906:Antibodies; D015415:Biomarkers; D010087:Oxides; D019210:Troponin I; D007204:Indium; D002097:C-Reactive Protein