Non-classical MHC-Ι genes in chronic hepatitis B and hepatocellular carcinoma.
The non-classical human leukocyte antigens (HLA)-E, HLA-G, and HLA-F have been shown to modulate immune responses. We examined whether non-classical HLA polymorphisms are associated with hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). Fifteen Single-nucleotide polymorphisms (SNPs) in these non-classical class I alleles were investigated by ligase detection reaction. A fragment of 650 bp located in the 3' untranslated region of HLA-G was investigated. Four SNPs (rs17875380, rs41557518, rs114465251, and rs115492845) were associated with altered susceptibility to HBV or HCC, and HLA-F*01:04, HLA-G*01:05N, and HLA-E*01:01 were associated with hepatitis B or hepatitis B complicated with HCC. Six of 16 designated HLA-E, -G, and -F haplotypes were associated with risk of hepatitis B or HCC. Our study provides healthy reference and detailed analyses of non-classical HLA class Ι polymorphisms that provide insight into immune mechanisms involved in susceptibility to hepatitis B and HCC.
Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, School of Medicine Zhejiang University, 310003, Hangzhou, Zhejiang Province, People's Republic of China.
Jian
J
Zhang
Lelin
L
Pan
Luyan
L
Chen
Xiaowen
X
Feng
Lin
L
Zhou
Shusen
S
Zheng
D000483:Alleles; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000276:immunology; D016022:Case-Control Studies; D005838:Genotype; D019694:Hepatitis B, Chronic / Q000235:genetics* / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000276:immunology; D006801:Humans; D015810:Linkage Disequilibrium; D008113:Liver Neoplasms / Q000235:genetics* / Q000276:immunology; D020641:Polymorphism, Single Nucleotide
D015395:Histocompatibility Antigens Class I