Native microbiota shape insect vector competence for human pathogens.
The resident microbiota of insect vectors can impede transmission of human pathogens. Recent studies have highlighted the capacity of endogenous bacteria to decrease viral and parasitic infections in mosquito and tsetse fly vectors by activating their immune responses or directly inhibiting pathogen development. These microbes may prove effective agents for manipulating the vector competence of malaria and other important human pathogens.
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, MD 21205-2179, USA.
Chris M
CM
Cirimotich
Jose L
JL
Ramirez
George
G
Dimopoulos
D000818:Animals; D003141:Communicable Diseases / Q000635:transmission*; D009033:Culicidae / Q000276:immunology / Q000382:microbiology; D006801:Humans; D007303:Insect Vectors / Q000276:immunology / Q000382:microbiology*; D054892:Metagenome; D014370:Tsetse Flies / Q000276:immunology / Q000382:microbiology