[Adipocytokines concentration and metabolic parameters in obese children].
BACKGROUND
Adipose tIssue secretes metabolically active proteins.


OBJECTIVE
1. To evaluate the prevalence of insulin resistance (IR) and metabolic syndrome (MS) in obese children as well as to measure plasma hormones concentrations: leptin, adiponectin, resistin in obese adolescents. 2. To assess the relationship between the studied adipocytokines and markers of metabolic syndrome.


METHODS
The study was carried out in 79 obese children, 10-18 years old, (mean 14.3ń1.9 years) and 35 normostenic healthy children (mean age 14.6ń2.37 years) as a control group. In all children adiponectin, leptin, resistin, lipid profile (triglycerides and HDL cholesterol) were estimated and plasma glucose and insulin levels were measured during the oral glucose tolerance test (OGTT). HOMA-IR was calculated.


RESULTS
MS was diagnosed in 28/78 of children (36% of subjects), IR in 54/79 patients (68% of subjects). There were higher concentrations of leptin and resistin (p <0.0001) and lower of adiponectin (p <0.05) in obese children in comparison to normostenic children. In obese girls with IR a higher concentration of leptin was observed comparing to obese girls without IR (p <0.05). A lower concentration of adiponectin was present in patients with IR and MS (p <0.05). There were no correlations between resistin concentration and IR level nor insulin concentration observed.


CONCLUSIONS
1. A sex-related relationship between plasma leptin and IR was observed. 2 Hypoadiponectinemia was connected with IR and other metabolic disorders typical for the metabolic syndrome, independently of BMI. 3. There were no statistically significant correlations between the resistin concentration and IR nor metabolic disorders, which might contradict the hypothesis of the role of resistin in the pathogenesis of insulin resistance in humans.
Katedra i Klinika Endokrynologii i Diabetologii Wieku Rozwojowego Akademii Medycznej, Wroclawiu. j_chrzan@tlen.pl
Joanna
J
Chrzanowska
Agnieszka
A
Zubkiewicz-Kucharska
Anna
A
Noczyńska
D052242:Adiponectin / Q000097:blood*; D000273:Adipose Tissue / Q000378:metabolism; D000293:Adolescent; D015992:Body Mass Index; D002648:Child; D005260:Female; D006729:Hormones, Ectopic / Q000097:blood*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D020738:Leptin / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood*; D012044:Regression Analysis; D052243:Resistin / Q000097:blood*
D052242:Adiponectin; D006729:Hormones, Ectopic; D020738:Leptin; D052243:Resistin