Does intratubular germ cell neoplasia, unclassified type exist in prepubertal, cryptorchid testes?
Six of 276 prepubertal testicular specimens had atypical germ cells. Specimens from 3 intersex patients met the criteria for intratubular germ cell neoplasia, unclassified type (IGCNU). Of the remaining 3 specimens (2 patients), 1 from a Down syndrome patient had centrally positioned germ cells with mild nuclear enlargement and hyperchromasia and expressed fetal germ cell markers (Oct3/4, placental alkaline phosphatase, CD117); it was classified as "delayed germ cell maturation". The remaining 2 specimens (1 patient) were diagnosed as IGCNU but, in retrospect, the patient had an undiagnosed intersex disorder. We therefore did not find a bona fide case of IGCNU in prepubertal testes apart from an intersex disorder.
Department of Pathology and Laboratory Medicine Indiana University, Indianapolis, Indiana, USA. fanr@iupui.edu
Rong
R
Fan
Thomas M
TM
Ulbright
D000293:Adolescent; D000469:Alkaline Phosphatase / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism; D002648:Child; D003456:Cryptorchidism / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D016208:Databases, Factual; D012734:Disorders of Sex Development / Q000150:complications / Q000378:metabolism / Q000473:pathology; D058851:GPI-Linked Proteins / Q000378:metabolism; D018237:Germinoma / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D007223:Infant; D007527:Isoenzymes / Q000378:metabolism; D008297:Male; D050814:Octamer Transcription Factor-3 / Q000378:metabolism; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism; D011627:Puberty; D013736:Testicular Neoplasms / Q000150:complications / Q000175:diagnosis*; D013737:Testis / Q000378:metabolism / Q000473:pathology*
D014408:Biomarkers, Tumor; D058851:GPI-Linked Proteins; D007527:Isoenzymes; D050814:Octamer Transcription Factor-3; C494173:POU5F1 protein, human; D019009:Proto-Oncogene Proteins c-kit; D000469:Alkaline Phosphatase; C019839:alkaline phosphatase, placental