Drug-induced subacute cutaneous lupus erythematosus related to doxycycline.
An 84-year-old woman presented with a three-month history of scaly, erythematous, annular papules and plaques on her chest, back, arms, and legs, which developed after a short course of doxycycline. Histopathologic examination of skin biopsy specimens was consistent with subacute cutaneous lupus erythematosus (SCLE). A presumptive diagnosis of drug-induced SCLE secondary to doxycycline was made. Although minocycline-induced SCLE is widely reported in the literature, there are no known previous case reports of doxycycline-induced SCLE.
Department of Dermatology, New York University, New York, New York, USA.
Kristen K
KK
Miller
Julie
J
Chu
Rishi
R
Patel
Hideko
H
Kamino
D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000974:Antibodies, Antinuclear / Q000097:blood; D001706:Biopsy; D004318:Doxycycline / Q000009:adverse effects* / Q000627:therapeutic use; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D005260:Female; D006801:Humans; D017512:Lichenoid Eruptions / Q000209:etiology; D008178:Lupus Erythematosus, Cutaneous / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology; D017319:Photosensitizing Agents / Q000009:adverse effects
D000900:Anti-Bacterial Agents; D000974:Antibodies, Antinuclear; D017319:Photosensitizing Agents; C035356:SS-A antibodies; D004318:Doxycycline