Sesquiterpene lactone, a potent drug molecule from Artemisia pallens wall with anti-inflammatory activity.
The present study was carried out to investigate the anti-inflammatory activities of bioactive secondary metabolites of Artemisia pallens Wall, an aromatic herb from family Asteraceae. The results provide evidence for the topical anti-inflammatory properties of Artemisia pallens Wall. The compounds were isolated from the acetone extract of the plant material. The isolates were tested on Swiss albino mice using 12-O-tetradecanoyl phorbol-13-acetate (TPA) induced ear edema. One of the molecules from the extract indicated potent anti-inflammatory activity equivalent to indometacin (CAS 53-86-1). Elucidation of the molecular structures by single crystal x-ray diffraction studies revealed the conformational differences that the six membered rings in both the molecules are at an angle of 28.79 degrees. Presence of hydroxy function for compound 2 may be responsible for higher potency.
Dr. T. R. Ingle Research Laboratory, Department of Chemistry, S. P. College, Pune, India.
Anjali D
AD
Ruikar
Ashwini V
AV
Misar
Ravindra B
RB
Jadhav
Supada R
SR
Rojatkar
Arvind M
AM
Mujumdar
Vedavati G
VG
Puranik
Nirmala R
NR
Deshpande
D000096:Acetone; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D019306:Artemisia / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D018360:Crystallography, X-Ray; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D006860:Hydrogen Bonding; D007213:Indomethacin / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008958:Models, Molecular; D010936:Plant Extracts / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology*; D012997:Solvents; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes; D012997:Solvents; D000096:Acetone; D013755:Tetradecanoylphorbol Acetate; D007213:Indomethacin