[Structure, function and molecular design strategies of antibacterial peptide SMAP-29: a review].
Antibacterial peptides are a family of host-defense peptides most of which are gene-encoded and produced by living organisms of all types. Antibacterial peptides are small molecular proteins with broad antimicrobial spectrum against bacteria, viruses, fungi and sometimes even as anticancer peptide. SMAP-29, a cathelicidin-like peptide derived from sheep myeloid, line alpha-helical Structure, exerts a powerful broad antimicrobial activity against different pathogens including Gram-positive and Gram-negative bacteria, fungi, viruses, parasites, spirochaetes, chlamydia and antiendotoxin activity, and particular antibacterial mechanism, rapidly to permeabilize membranes of susceptible organisms. This paper summarizes the lately research progress of SMAP-29 and Variants including the characteristics of structure, structure-activity relationships, mode of action, diverse biological functions, gene recombinant and expression. We put emphasis on the necessity of molecular design, and primary and secondary structure-based modification, to provides a strong foundation for further drug development and design of SMAP-29.
Shaanxi Key Laboratory of Resource Biology, Shaanxi University of Technology, Hanzhong 723000, China. cchen2008@yahoo.com
Chen
C
Chen
Sanqiao
S
Wu
Xinsheng
X
Li
Xiaoying
X
Zhang
Maocang
M
Yan
D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D001798:Blood Proteins / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D054804:Cathelicidins / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D015195:Drug Design; D011994:Recombinant Proteins / Q000737:chemistry* / Q000235:genetics; D012756:Sheep
D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins; D054804:Cathelicidins; D011994:Recombinant Proteins; C403305:SMAP29 protein, Ovis aries