Tuberculous hilar lymphadenopathy progressing after isoniazid administration.
Right hilar lymphadenopathy was the only radiologic finding in an immunocompetent 19-year-old man with a positive whole blood interferon-γ enzyme-linked immunosorbent test (QuantiFERON-TB-2G). Because his initial treating physician did not notice the lung lesion on chest radiography, isoniazid (INH) monotherapy was begun with subsequent progression of the lymphadenopathy. We must take into consideration even hilar lymphadenopathy in patients with tuberculosis (TB) disease without detectable Mycobacterium (M.) tuberculosis organisms, because INH monotherapy may result in progression of the TB lesion.
Department of Pulmonary Medicine, National Hospital Organization Matsue Medical Center, 5-8-31 Agenogi, Matsue, Shimane 690-8556, Japan. yano@matsue.hosp.go.jp
Shuichi
S
Yano
D000995:Antitubercular Agents / Q000627:therapeutic use*; D006801:Humans; D007121:Immunocompetence; D059425:Interferon-gamma Release Tests; D007538:Isoniazid / Q000627:therapeutic use*; D055985:Latent Tuberculosis / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D008206:Lymphatic Diseases / Q000276:immunology / Q000473:pathology*; D008297:Male; D055815:Young Adult
D000995:Antitubercular Agents; D007538:Isoniazid