DNA-repair gene variants are associated with glioblastoma survival.
Patient outcome from glioma may be influenced by germline variation. Considering the importance of DNA repair in cancer biology as well as in response to treatment, we studied the relationship between 1458 SNPs, which captured the majority of the common genetic variation in 136 DNA repair genes, in 138 glioblastoma samples from Sweden and Denmark. We confirmed our findings in an independent cohort of 121 glioblastoma patients from the UK. Our analysis revealed nine SNPs annotating MSH2, RAD51L1 and RECQL4 that were significantly (p < 0.05) associated with glioblastoma survival.
Department of Radiation Sciences, Oncology, Umeå University Hospital, Umeå, Sweden. carl.wibom@onkologi.umu.se
Carl
C
Wibom
Sara
S
Sjöström
Roger
R
Henriksson
Thomas
T
Brännström
Helle
H
Broholm
Patrik
P
Rydén
Christoffer
C
Johansen
Helle
H
Collatz-Laier
Sara
S
Hepworth
Patricia A
PA
McKinney
Lara
L
Bethke
Richard S
RS
Houlston
Ulrika
U
Andersson
Beatrice S
BS
Melin
D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000235:genetics / Q000401:mortality*; D016022:Case-Control Studies; D004260:DNA Repair / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D003718:Denmark; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005909:Glioblastoma / Q000235:genetics / Q000401:mortality*; D006801:Humans; D008297:Male; D008875:Middle Aged; D051718:MutS Homolog 2 Protein / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D053484:RecQ Helicases / Q000235:genetics*; D015996:Survival Rate; D013548:Sweden; D006113:United Kingdom; D055815:Young Adult
D004268:DNA-Binding Proteins; C413002:RAD51B protein, human; C506731:RECQL4 protein, human; C497172:MSH2 protein, human; D051718:MutS Homolog 2 Protein; D053484:RecQ Helicases