Association of subcutaneous and visceral fat mass with serum concentrations of adipokines in subjects with type 2 diabetes mellitus.
The goal of the study was to examine the association of subcutaneous and visceral fat mass with serum concentrations of adipokines in 130 subjects with type 2 diabetes mellitus. The levels of serum high sensitivity C-reactive protein (HS-CRP), adiponectin, high-molecular-weight (HMW) adiponectin, interleukin-18, and retinol-binding protein 4 were measured. Percentage body fat was determined by dual energy X-ray absorptiometry, and subcutaneous and visceral fat areas were measured by abdominal CT. HS-CRP had significant positive correlations with percentage body fat and subcutaneous fat area, and a particularly significant positive correlation with visceral fat area. Serum adiponectin had a negative correlation with the subcutaneous and visceral fat areas, with the strongest correlation with the visceral fat area. Similar results were obtained for HMW adiponectin. Serum adiponectin had a negative correlation with visceral fat area in subjects with a visceral fat area < 100 cm², but not in those with a visceral fat area ≥ 100 cm². In contrast, serum HS-CRP showed a positive correlation with visceral fat area in subjects with visceral fat area ≥ 100 cm², but not in those with a visceral fat area < 100 cm². These findings indicate that an increased visceral fat area is associated with inflammatory changes, and that inflammatory reactions may alter the functional properties of visceral fat in type 2 diabetes mellitus.
Department of Medicine, Jichi Medical University Saitama Medical Center, Saitama, Japan.
Tomoyuki
T
Saito
Miho
M
Murata
Taeko
T
Otani
Hiroyuki
H
Tamemoto
Masanobu
M
Kawakami
San-E
SE
Ishikawa
D054392:Adipokines / Q000097:blood*; D052242:Adiponectin / Q000097:blood* / Q000737:chemistry; D050154:Adiposity; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000276:immunology / Q000473:pathology*; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D009765:Obesity / Q000150:complications; D012727:Sex Characteristics; D050507:Subcutaneous Fat, Abdominal / Q000276:immunology / Q000473:pathology*; D055815:Young Adult
C499918:ADIPOQ protein, human; D054392:Adipokines; D052242:Adiponectin; D002097:C-Reactive Protein