Preparation of chondroitin sulfate nanocapsules for use as carries by the interfacial polymerization method.
In this paper, the method of interfacial polymerization in emulsion was employed to fabricate chondroitin sulfate-methacrylate (ChSMA) nanocapsules, in which poor water-soluble drug of indomethacin (IND) could be effectively encapsulated. The morphology and the size distribution of synthesized nanocapsules were characterized by field emission scanning electron microscopy (FESEM) and dynamic light scattering (DLS) techniques. The quantitative drug loading was investigated. The IND/ChSMA noodle-like self-assemblies were observed with the increase of IND feed concentration, and the interactions between IND and ChSMA were illuminated by FT-IR and XRD measurements. The in vitro drug release of IND-loaded nanocapsules and IND/ChSMA self-assemblies were also carried out in simulated body fluid pH 7.4 at 37°C.
Department of Pharmacology, Medical School of Yangzhou University, Yangzhou, People's Republic of China. xijq@yzu.edu.cn
Juqun
J
Xi
Ling
L
Zhou
Yonghe
Y
Fei
D002809:Chondroitin Sulfates / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D007213:Indomethacin / Q000008:administration & dosage / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008689:Methacrylates / Q000737:chemistry; D008855:Microscopy, Electron, Scanning / Q000379:methods; D053769:Nanocapsules / Q000737:chemistry*; D058105:Polymerization; D012542:Scattering, Radiation; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013696:Temperature; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
D004337:Drug Carriers; D008689:Methacrylates; D053769:Nanocapsules; D014867:Water; D002809:Chondroitin Sulfates; D007213:Indomethacin