Beneficial effects of hydrocortisone or spironolactone coating on foreign body response to mesh biomaterial in a mouse model.
Prosthetic reinforcements markedly reduce the risk of hernia recurrence. However, the implantation of meshes is related to an inflammatory foreign body reaction (FBR) with serious complications (i.e., persistent seroma, wound infection, mesh migration, entrapment, chronic pain). Adrenal hormones profoundly modify inflammatory response. Their effects on FBR however, remain ill defined. We therefore studied the FBR to polyvinylidenfluoride (PVDF) mesh material that was coated with four different substances: hydrocortisone (COR) or mifepristone (MIF), which respectively stimulate and block the glucocorticoid receptor, and aldosterone (ALD) or spironolactone (SPI), which respectively stimulate and block the mineralocorticoid receptor. The coated substances were released from the meshes within 24 h. Seven, 21, and 90 days after implantation, the specimen was evaluated for collagen formation, granuloma size, inflammatory activity, and angiogenesis. COR and SPI coating protected from inflammatory response, while ALD and MIF coating showed little difference to the control group. The COR and SPI groups showed smaller granuloma sizes at all time points, as well as a reduced number of inflammatory cells (p < 0.001) at day 90, and decreased collagen formation starting after 21 days (p < 0.05). There was a negative correlation for angiogenesis with inflammation around foreign body structures. In summary, these results suggest that early and temporary stimulation of the glucocorticoid receptor or blockade of the mineralocorticoid receptor have beneficial effects on FBR in the long term.
Surgical Department of the University Hospital of the UVA/AMC, 1105 AZ, Amsterdam, The Netherlands.
Christopher J
CJ
Brandt
Daniel
D
Kammer
Anette
A
Fiebeler
Uwe
U
Klinge
D000818:Animals; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D003094:Collagen / Q000378:metabolism; D004195:Disease Models, Animal; D005549:Foreign-Body Reaction / Q000139:chemically induced* / Q000150:complications / Q000473:pathology*; D006099:Granuloma / Q000150:complications / Q000473:pathology; D006854:Hydrocortisone / Q000494:pharmacology*; D007249:Inflammation / Q000150:complications / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009389:Neovascularization, Pathologic / Q000150:complications; D011145:Polyvinyls / Q000009:adverse effects*; D013148:Spironolactone / Q000494:pharmacology*; D018709:Statistics, Nonparametric; D005465:Fluorocarbon Polymers
D020099:Coated Materials, Biocompatible; D003094:Collagen; D006854:Hydrocortisone; D011145:Polyvinyls; D013148:Spironolactone; C024865:polyvinylidene fluoride; D005465:Fluorocarbon Polymers