[Effects and mechanism of five Chinese patent medicines on focal cerebral ischemia].
OBJECTIVE
To study the differences between the effects of five Chinese patent medicines on focal cerebral ischemia. Tongsaimai Tablet (TSM), Tongxinluo Capsule (TXL), Buchangnaoxintong (BCNXT), Fufangxueshuantong Capsule (FFXST) and Xuesaitong Capsule.


METHODS
The focal cerebral ischemia rats were modeled by electric coagulation. The water content of brain, cerebral index, cerebral infarction rate, superoxide dismutase (SOD), malondialdehyde (MDA), testosterone (T), estradiol (E2) in serum and expression of estrogen receptor (ER) in brain were detected after adminstration.


RESULTS
Compared with the sham group, the water content of brain, cerebral index, cerebral infarction rate the content of MDA and E2 in serum and the ER expression of focal cerebral ischemia rats increased, the activity of SOD and the content of T were decreased. All these five Chinese patent medicines could reduce encephaledema (except TXL) and the infarct range, decrease the content of MDA and the expression of ER. BCNXT and TSM could increase the activify of SOD; FFXST, XST and TSM could increase the content of T; BCNXT, FFXST and XST could decrease the content of E2.


CONCLUSIONS
The five Chinese patent medicines have the protection effect on cerebral ischemia, but their mechanisms are not exactly the same.
College of pharmacy, Nanjing University of Chinese Medicine, Nanjing 210029, China. hope.zy@163.com
Yue
Y
Zhao
Qi-chun
QC
Zhang
Qing
Q
Zhu
Shu-mei
SM
Yin
Hong-mei
HM
Wen
Hui-min
HM
Bian
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D001929:Brain Edema / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D002545:Brain Ischemia / Q000097:blood / Q000473:pathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000097:blood; D013739:Testosterone / Q000097:blood; D014867:Water / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; D014867:Water; D013739:Testosterone; D008315:Malondialdehyde; D013482:Superoxide Dismutase