Electrospun cellulose acetate phthalate fibers for semen induced anti-HIV vaginal drug delivery.
Despite many advances in modern medicine, human immunodeficiency virus (HIV) still affects the health of millions of people world-wide and much effort is put in developing methods to either prevent infection or to eradicate the virus after infection has occurred. Here, we describe the potential use of electrospun cellulose acetate phthalate (CAP) fibers as a tool to prevent HIV transmission. During the electrospinning process, anti-viral drugs can easily be incorporated in CAP fibers. Interestingly, as a result of the pH-dependent solubility of CAP, the fibers are stable in vaginal fluid (the healthy vaginal flora has a pH of below 4.5), whereas the addition of small amounts of human semen (pH between 7.4 and 8.4) immediately dissolves the fibers which results in the release of the encapsulated drugs. The pH-dependent release properties have been carefully studied and we show that the released anti-viral drugs, together with the CAP which has been reported to have intrinsic antimicrobial activity, efficiently neutralize HIV in vitro.
Lab of General Biochemistry and Physical Pharmacy, Ghent University, Harelbekestraat 72, B-9000 Gent, Belgium.
Chaobo
C
Huang
Stefaan J
SJ
Soenen
Ellen
E
van Gulck
Guido
G
Vanham
Joanna
J
Rejman
Serge
S
Van Calenbergh
Chris
C
Vervaet
Tom
T
Coenye
Hans
H
Verstraelen
Marleen
M
Temmerman
Jo
J
Demeester
Stefaan C
SC
De Smedt
D000282:Administration, Intravaginal; D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D005260:Female; D006801:Humans; D008297:Male; D012661:Semen / Q000737:chemistry*
D019380:Anti-HIV Agents; D002482:Cellulose; C011708:cellulose acetate phthalate