Short term inhalation toxicity of a liquid aerosol of CdS/Cd(OH)₂ core shell quantum dots in male Wistar rats.
Colloidal quantum dots (QD) show great promise as fluorescent markers. The QD used in this study were obtained in aqueous medium rather than the widely used colloidal QD. Both methodologies used for the production of QD are associated with the presence of heavy metals such as cadmium (Cd). Here we investigate the short-term inhalation toxicity of water-soluble core-shell CdS/Cd(OH)₂ QD. Male Wistar rats were head-nose exposed for 6 h/day on 5 days at the technically maximum concentration (0.52 mg Cd/m³). Histological examination was performed directly after the last exposure. Additional rats were used for Cd organ burden determinations. Clinical parameters in blood, bronchoalveolar lavage fluid and lung tissue were determined 3 days after the last exposure. To analyze the reversibility or progression of effects, the examinations were performed again after a recovery period of 3 weeks. The results of the study indicate that CdS/Cd(OH)₂ QD caused local neutrophil inflammation in the lungs that partially regressed after the 3-week recovery period. There was no evidence that QD were translocated to the central nervous system nor that a systemic acute phase response occurred.
BASF SE, Experimental Toxicology and Ecology, 67056 Ludwigshafen, Germany.
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Ma-Hock
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Brill
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Wohlleben
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Ravenzwaay
D000336:Aerosols; D000818:Animals; D019187:Cadmium Compounds / Q000008:administration & dosage / Q000633:toxicity*; D007249:Inflammation / Q000139:chemically induced; D019570:Inhalation Exposure; D008168:Lung / Q000187:drug effects*; D008297:Male; D046529:Microscopy, Electron, Transmission; D009504:Neutrophils / Q000187:drug effects; D045663:Quantum Dots; D051381:Rats; D017208:Rats, Wistar; D013440:Sulfides / Q000008:administration & dosage / Q000633:toxicity*; D014018:Tissue Distribution
D000336:Aerosols; D019187:Cadmium Compounds; D013440:Sulfides; C034939:cadmium sulfide