Epigenetic diet: impact on the epigenome  and cancer.
A number of bioactive dietary components are of particular interest in the field of epigenetics. Many of these compounds display anticancer properties and may play a role in cancer prevention. Numerous studies suggest that a number of nutritional compounds have epigenetic targets in cancer cells. Importantly, emerging evidence strongly suggests that consumption of dietary agents can alter normal epigenetic states as well as reverse abnormal gene activation or silencing. Epigenetic modifications induced by bioactive dietary compounds are thought to be beneficial. Substantial evidence is mounting proclaiming that commonly consumed bioactive dietary factors act to modify the epigenome and may be incorporated into an 'epigenetic diet'. Bioactive nutritional components of an epigenetic diet may be incorporated into one's regular dietary regimen and used therapeutically for medicinal or chemopreventive purposes. This article will primarily focus on dietary factors that have been demonstrated to influence the epigenome and that may be used in conjunction with other cancer prevention and chemotherapeutic therapies.
Department of Biology, University of Alabama at Birmingham, 1300 University Boulevard, Birmingham, AL 35294, USA.
Tabitha M
TM
Hardy
Trygve O
TO
Tollefsbol
D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D002392:Catechin / Q000031:analogs & derivatives / Q000494:pharmacology; D003474:Curcumin / Q000494:pharmacology; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000037:antagonists & inhibitors*; D019175:DNA Methylation / Q000502:physiology*; D004032:Diet; D044127:Epigenesis, Genetic / Q000502:physiology*; D057890:Epigenomics; D019833:Genistein / Q000494:pharmacology; D006657:Histones / Q000037:antagonists & inhibitors*; D006801:Humans; D017879:Isothiocyanates / Q000494:pharmacology; D035683:MicroRNAs / Q000037:antagonists & inhibitors*; D009369:Neoplasms / Q000178:diet therapy / Q000517:prevention & control*; D059808:Polyphenols / Q000494:pharmacology; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology; D013662:Tea / Q000737:chemistry
D016588:Anticarcinogenic Agents; D006657:Histones; D017879:Isothiocyanates; D035683:MicroRNAs; D059808:Polyphenols; D013267:Stilbenes; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate; D019833:Genistein; D004248:DNA (Cytosine-5-)-Methyltransferases; D003474:Curcumin; D000077185:Resveratrol