Salmonella, the host and its microbiota.
The intestine is host to a diverse bacterial community whose structure, at the phylum level, is maintained through unknown mechanisms. Acute inflammation triggered by enteric pathogens, such as Salmonella enterica serotype Typhimurium (S. Typhimurium), is accompanied by changes in the bacterial community structure marked by an outgrowth of the pathogen. Recent studies show that S. Typhimurium can harness benefit from the host response to edge out the beneficial bacterial species that dominate in the healthy gut. The elucidation of how S. Typhimurium alters the bacterial community structure during gastroenteritis is beginning to provide insights into mechanisms that dictate the balance between the host and its microbiota.
Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, CA, United States.
Parameth
P
Thiennimitr
Sebastian E
SE
Winter
Andreas J
AJ
Bäumler
D058448:Biota; D005759:Gastroenteritis / Q000382:microbiology*; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006801:Humans; D054892:Metagenome; D012480:Salmonella Infections / Q000382:microbiology*; D012486:Salmonella typhimurium / Q000254:growth & development* / Q000472:pathogenicity*