IL28B rs12979860 genotype and spontaneous clearance of hepatitis C virus in a multi-ethnic cohort of injection drug users: evidence for a supra-additive association.
Among 1369 Urban Health Study participants, we evaluated genetic models for the association of IL28B genotype (rs12979860 and rs8099917) with hepatitis C virus (HCV) clearance. For rs12979860, adjusted odds ratios for spontaneous HCV clearance were as follows: IL28B-CC, 3.88 (P < .001); IL28B-CT, 1.48 (P = .08). On the basis of Akaike information criteria values and χ(2) tests, a supra-additive (quadratic) model fit these data best. Models based on rs8099917 provided poorer fit. Evidence that a supra-additive rs12979860-based model best fits the association of IL28B-genotype with HCV clearance may improve clinical prediction models and foster a better understanding of functional mechanisms underlying this association.
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA.
Fatma M
FM
Shebl
Ruth M
RM
Pfeiffer
Dianna
D
Buckett
Brian
B
Muchmore
Sabrina
S
Chen
Myhanh
M
Dotrang
Ludmila
L
Prokunina-Olsson
Brian R
BR
Edlin
Thomas R
TR
O'Brien
D000328:Adult; D005260:Female; D018628:Gene Dosage; D016174:Hepacivirus; D019698:Hepatitis C, Chronic / Q000097:blood / Q000208:ethnology / Q000235:genetics* / Q000821:virology; D006801:Humans; D007372:Interferons; D007378:Interleukins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D012367:RNA, Viral / Q000097:blood; D015819:Substance Abuse, Intravenous / Q000208:ethnology; D019562:Viral Load; D000095022:Interferon Lambda
D007372:Interferons; D007378:Interleukins; D012367:RNA, Viral; C000624353:interferon-lambda, human; D000095022:Interferon Lambda