Expedient preparation of trifluoromethyl-substituted benzofuranols.
Direct access to 3-trifluoromethyl-substituted benzofuranols is presented. The products are obtained in good yields from commercially available salicylaldehydes by using in situ generated trifluoromethyl diazomethane and boron trifluoride as an activator. As shown in a representative example, the products can be transformed into the corresponding trifluoromethyl-substituted benzofurans.
Laboratorium für Organische Chemie, ETH Zürich, CH-8093 Zürich, Switzerland.
Bill
B
Morandi
Erick M
EM
Carreira
D001572:Benzofurans / Q000138:chemical synthesis*; D005461:Fluorine / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure
D001572:Benzofurans; D005461:Fluorine