Plasma osteopontin is not associated with vascular markers of subclinical atherosclerosis in a population of young adults without symptoms of cardiovascular disease. The Cardiovascular Risk in Young Finns Study.
OBJECTIVE
Osteopontin is used as a biomarker for measuring the severity of atherosclerosis, but the role of osteopontin in the pathogenesis of atherosclerosis is not clear.


METHODS
The distribution and determinants of osteopontin were studied in a randomized cohort of 1,817 young adults (aged 30–45 years) without clinical symptoms of atherosclerosis.


RESULTS
The mean ± SD osteopontin concentration was 60.7 ± 15.6 μg/mL in men and 51.7 ± 16.0 μg/mL in women. In multivariable models the correlates of osteopontin explained 6.9% (Model R² of the total variation in osteopontin in men, including CRP (β = 3.02, p < 0.0001), SHBG (β = 0.21, p < 0.0001), total cholesterol (β = − 1.78, p = 0.002), age (β = − 0.26, p = 0.02) and alcohol use (β = 0.57, p = 0.04) and of these CRP had the greatest influence (Partial R² = 2.1%). In women, multivariable correlates of osteopontin included CRP (β = 2.90, p < 0.0001), total cholesterol (β = − 1.99, p = 0.002), insulin (β = − 1.76, p = 0.001), physical activity (β = 0.66, p = 0.03), adiponectin (β = 0.25, p = 0.008) and diastolic blood pressure (β = 0.14, p = 0.003). These five variables explained 6.7% (Model R²) of the total variation in osteopontin, with CRP (Partial R² = 2.7%) having the greatest influence. Osteopontin was not associated with carotid intima-media thickness, carotid elasticity, brachial endothelial function or the presence of a carotid plaque in either sex.


CONCLUSIONS
We found no evidence of association between osteopontin levels and early vascular markers of atherosclerosis in asymptomatic young adults, suggesting that osteopontin is not implicated in the preclinical atherosclerotic changes in vascular structure and function.
Department of Clinical Physiology, Turku University Hospital, Turku, Finland. marwen@utu.fi
Maria
M
Wendelin-Saarenhovi
Mervi
M
Oikonen
Britt-Marie
BM
Loo
Markus
M
Juonala
Mika
M
Kähönen
Jorma S A
JS
Viikari
Olli T
OT
Raitakari
D000328:Adult; D050197:Atherosclerosis / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis*; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D059168:Carotid Intima-Media Thickness; D002784:Cholesterol / Q000097:blood; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D005387:Finland; D006801:Humans; D008297:Male; D053495:Osteopontin / Q000097:blood*; D012307:Risk Factors; D012737:Sex Factors; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology
D015415:Biomarkers; D053495:Osteopontin; D002097:C-Reactive Protein; D002784:Cholesterol