Platelet dysfunction in acute leukemias and myelodysplastic syndromes.
The hemorrhagic and thrombotic diathesis represents a frequent complication in myelodysplastic syndromes (MDS) and in acute leukemias. They are correlated with the number of the platelets, but also with their qualitative disorders, such as membrane glycoprotein changes. The latter are revealed by many platelet studies including flow-cytometry and comprise modified activation, secretion and aggregation patterns.
Ana Maria
AM
Vlădăreanu
Veronica
V
Vasilache
H
H
Bumbea
Minodora
M
Onisâi
D000208:Acute Disease; D001791:Blood Platelet Disorders / Q000097:blood / Q000209:etiology / Q000473:pathology; D001792:Blood Platelets / Q000378:metabolism / Q000473:pathology; D005434:Flow Cytometry; D006801:Humans; D007938:Leukemia / Q000097:blood / Q000150:complications*; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000150:complications*; D010974:Platelet Aggregation; D010976:Platelet Count; D010979:Platelet Function Tests; D010980:Platelet Membrane Glycoproteins / Q000145:classification / Q000378:metabolism
D010980:Platelet Membrane Glycoproteins