Synthesis, characterization and antioxidant capacity of naringenin-oxime.
The recognition of the benefits of polyphenolic antioxidants is eliciting increasing interest in the search for new polyphenolic derivatives with improved antioxidant activity. Since naringenin (4',5,7-trihydroxyflavanone) (NG) is one of the most abundant citrus and grapefruit polyphenolics and flavanone oximes were used in the synthesis of anticancer and radioprotector compounds having antiradical activity, the corresponding oxime of NG, naringenin oxime (NG-Ox), was synthesized and investigated. The structure of NG-Ox was characterized by FT-IR, (1)H NMR, elemental analysis, and the synthesized compound was screened for its antioxidant capacity by using the cupric reducing antioxidant capacity (CUPRAC) method. Trolox equivalent antioxidant capacity (TEAC) of NG-Ox was measured to be higher than that of the parent compound, NG. Other parameters of antioxidant activity (scavenging effects on *OH, O(2)*-, and H(2)O(2)) of NG-Ox were also determined.
Department of Chemistry, Faculty of Science and Letters, Harran University, Osmanbey 63300, Şanlıurfa, Turkey.
Baki
B
Türkkan
Mustafa
M
Ozyürek
Mustafa
M
Bener
Kubilay
K
Güçlü
Reşat
R
Apak
D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002839:Chromans / Q000494:pharmacology; D002957:Citrus / Q000737:chemistry; D044950:Flavanones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006861:Hydrogen Peroxide / Q000378:metabolism; D017665:Hydroxyl Radical / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction; D010091:Oximes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013053:Spectrophotometry; D017550:Spectroscopy, Fourier Transform Infrared; D013481:Superoxides / Q000378:metabolism
D000975:Antioxidants; D002839:Chromans; D044950:Flavanones; D010091:Oximes; D013481:Superoxides; D017665:Hydroxyl Radical; D006861:Hydrogen Peroxide; C005273:naringenin; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid