The successful management of diffuse lymphangiomatosis using sirolimus: a case report.
Lymphangiomatosis is a rare and fatal congenital lymphatic malformation. Because the natural course of the disease affects multiple body systems, the management can be challenging. This article presents a novel approach to the treatment of diffuse lymphangiomatosis using sirolimus. The reported case involves a 4-month-old male with a known lymphatic malformation who presented to the emergency department with respiratory difficulties. Sirolimus was successful at significantly reducing our patient's mass at a relatively low target level of 5 to 10 μg/L. The use of sirolimus for the treatment of lymphangiomatosis should be studied further in the setting of a formal trial.
Faculty of Medicine, University of Ottawa, Ottawa, Canada.
Jason
J
Reinglas
Raveena
R
Ramphal
Matthew
M
Bromwich
D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D008202:Lymphangioma / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008223:Lymphoma / Q000175:diagnosis / Q000188:drug therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D020123:Sirolimus / Q000627:therapeutic use*; D014463:Ultrasonography
D000903:Antibiotics, Antineoplastic; D020123:Sirolimus