Heart type fatty acid binding protein in relation to pharmacologic scintigraphy in coronary artery disease.
BACKGROUND
Heart-type fatty acid-binding protein (H-FABP) is a marker of myocardial necrosis, but whether it increases during myocardial ischemia is not known. This study investigated whether serum levels of H-FABP change during adenosine stress testing and nuclear imaging in patients with stable coronary artery disease.


METHODS
Thirty stable patients with established coronary artery disease on their medications were studied. Sampling was performed before the stress test, at the end of adenosine infusion, as well as 1, 2 and 3 h after the completion of the infusion.


RESULTS
No difference in H-FABP serum levels were found at the five pre-specified time points in the overall group (p=0.99); furthermore, there was no significant difference regardless of the test result--positive (p=1) or negative (p=0.98).


CONCLUSIONS
It is concluded that H-FABP does not change significantly during pharmacologic stress testing in patients with known coronary artery disease and there is no difference whether there is inducible ischemia or not.
2 nd Department of Cardiology, Onassis Cardiac Surgery Center, 356 Syngrou Avenue, 17674 Athens, Greece. esbarouni@yahoo.gr
Eftihia
E
Sbarouni
Panagiota
P
Georgiadou
Maria
M
Koutelou
Mihas
M
Constantinos
Antigoni
A
Chaidaroglou
Demitris
D
Degiannis
Vassilis
V
Voudris
D000241:Adenosine / Q000378:metabolism; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000473:pathology*; D005080:Exercise Test; D050556:Fatty Acid-Binding Proteins / Q000097:blood* / Q000378:metabolism; D006801:Humans; D011859:Radiography; D011877:Radionuclide Imaging
D050556:Fatty Acid-Binding Proteins; D000241:Adenosine