Survival predictors of patients with primary duodenal adenocarcinoma.
This single-institution experience retrospectively reviewed the outcomes in 21 patients with primary duodenal adenocarcinoma. Twelve patients underwent curative surgery, and 9 patients underwent palliative surgery at the Chiba University Hospital. The maximum follow-up period was 8650 days. All pathologic specimens from endoscopic biopsy and surgical specimens were reviewed and categorized. Twelve (57.1%) patients underwent curative surgery (R0): 4 pancreaticoduodenectomies (PD), 4 pylorus-preserving PDs (PpPD), 2 local resections of the duodenum and 2 endoscopic mucosal resections (EMR). Palliative surgery was performed for 9 patients (42.9%) following gastro-intestinal bypass. The median cause-specific survival times were 1784 days (range 160-8650 days) in the curative surgery group and 261 days (range 27-857 days) in the palliative surgery group (P = 0.0003, log-rank test). The resectability of primary duodenal adenocarcinoma was associated with a smaller tumor size, a lower degree of tumor depth invasiveness, and less spread to the lymph nodes and distant organs.
Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
Hiroshi
H
Kawahira
Fumihiko
F
Miura
Kenichi
K
Saigo
Akinao
A
Matsunaga
Toshiyuki
T
Natsume
Takashi
T
Akai
Daisuke
D
Horibe
Kazufumi
K
Suzuki
Yoshihiro
Y
Nabeya
Hideki
H
Hayashi
Hideaki
H
Miyauchi
Kiyohiko
K
Shuto
Takehide
T
Asano
Hisahiro
H
Matsubara
D000230:Adenocarcinoma / Q000175:diagnosis / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D004379:Duodenal Neoplasms / Q000175:diagnosis / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D004386:Duodenum / Q000601:surgery; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000601:surgery; D053208:Kaplan-Meier Estimate; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010166:Palliative Care; D016577:Pancreaticoduodenectomy / Q000379:methods