CYP1A1 Ile462Val polymorphism and susceptibility to lung cancer:  a meta-analysis based on 32 studies.
Lung cancer is the second most common human malignant disease and the leading cause of cancer-related mortality worldwide. The effect of CYP1A1 IleVal polymorphism on susceptibility to lung cancer has been researched extensively over the last two decades. However, controversial results were obtained. To provide a more robust estimate of the effect, a meta-analysis was carried out. We systematically searched the PubMed database for studies published before August 2010, without language restriction. On the basis of our search criteria, a total of 32 studies (5126 patients and 6974 controls) were included in the meta-analysis. Overall, CYP1A1 IleVal polymorphism is associated with lung cancer risk (GG vs. AG+AA: odds ratio=1.61, 95% confidence interval: 1.19-2.17; GG vs. AA: odds ratio=1.70, 95% confidence interval: 1.23-2.35). Ethnic subgroup analyses showed that a significant association was found in Asians, but not in Africans, Caucasians, or other populations. In subgroup analyses by histology, the result is not reliable. In conclusion, this meta-analysis suggests that the CYP1A1 IleVal polymorphism might play a modest role in susceptibility to lung cancer, especially in Asians.
Department of Center for Disease Control and Prevention of Shaanxi Province, Xi'an, China.
Jing-Jun
JJ
Wang
Yuan
Y
Zheng
Liang
L
Sun
Li
L
Wang
Peng-Bo
PB
Yu
Hong-Lei
HL
Li
Xiao-Ping
XP
Tian
Jian-Hua
JH
Dong
Lei
L
Zhang
Jing
J
Xu
Wei
W
Shi
Tao-Yan
TY
Ma
D044466:Asian People; D016022:Case-Control Studies; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D007532:Isoleucine / Q000235:genetics; D008175:Lung Neoplasms / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D014633:Valine / Q000235:genetics
D005819:Genetic Markers; D007532:Isoleucine; C569463:CYP1A1 protein, human; D019363:Cytochrome P-450 CYP1A1; D014633:Valine