Polyunsaturated fatty acid metabolism in prostate cancer.
Polyunsaturated fatty acids (PUFA) play important roles in the normal physiology and in pathological states including inflammation and cancer. While much is known about the biosynthesis and biological activities of eicosanoids derived from ω6 PUFA, our understanding of the corresponding ω3 series lipid mediators is still rudimentary. The purpose of this review is not to offer a comprehensive summary of the literature on fatty acids in prostate cancer but rather to highlight some of the areas where key questions remain to be addressed. These include substrate preference and polymorphic variants of enzymes involved in the metabolism of PUFA, the relationship between de novo lipid synthesis and dietary lipid metabolism pathways, the contribution of cyclooxygenases and lipoxygenases as well as terminal synthases and prostanoid receptors in prostate cancer, and the potential role of PUFA in angiogenesis and cell surface receptor signaling.
Department of Cancer Biology, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA.
Isabelle M
IM
Berquin
Iris J
IJ
Edwards
Steven J
SJ
Kridel
Yong Q
YQ
Chen
D000818:Animals; D004042:Dietary Fats, Unsaturated / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000096:biosynthesis / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism; D058945:Lipoxygenases / Q000378:metabolism; D008297:Male; D009389:Neovascularization, Pathologic / Q000378:metabolism; D010084:Oxidation-Reduction; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000098:blood supply / Q000201:enzymology / Q000378:metabolism*; D011982:Receptors, Prostaglandin / Q000378:metabolism; D015398:Signal Transduction
D004042:Dietary Fats, Unsaturated; D005231:Fatty Acids, Unsaturated; D011982:Receptors, Prostaglandin; D058945:Lipoxygenases; D011451:Prostaglandin-Endoperoxide Synthases