In silico study of the ion channel formed by tolaasin I produced by Pseudomonas tolaasii.
A toxin produced by Pseudomonas tolaasii, tolaasin, causes brown blotch disease in mushrooms. Tolaasin forms pores on the cellular membrane and destroys cell structure. Inhibiting the ability of tolaasin to form ion channels may be an effective method to protect against attack by tolaasin. However, it is first necessary to elucidate the three-dimensional structure of the ion channels formed by tolaasin. In this study, the structure of the tolaasin ion channel was determined in silico based on data obtained from nuclear magnetic resonance experiments.
Division of Bioscience and Biotechnology, BMIC, Konkuk University, Seoul 143-701, Korea.
Geunhyeong
G
Jo
Doseok
D
Hwang
Sunhee
S
Lee
Yoonkyung
Y
Woo
Jiye
J
Hyun
Yeonjoong
Y
Yong
Kyungrai
K
Kang
Dong-woon
DW
Kim
Yoongho
Y
Lim
D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D001427:Bacterial Toxins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D047630:Depsipeptides / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D007473:Ion Channels / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011549:Pseudomonas / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
D001426:Bacterial Proteins; D001427:Bacterial Toxins; D047630:Depsipeptides; D007473:Ion Channels; C067241:tolaasin protein, Pseudomonas tolaasii