Preterm cerebellar growth impairment after postnatal exposure to glucocorticoids.
As survival rates of preterm newborns improve as a result of better medical management, these children increasingly show impaired cognition. These adverse cognitive outcomes are associated with decreases in the volume of the cerebellum. Because animals exhibit reduced preterm cerebellar growth after perinatal exposure to glucocorticoids, we sought to determine whether glucocorticoid exposure and other modifiable factors increased the risk for these adverse outcomes in human neonates. We studied 172 preterm neonatal infants from two medical centers, the University of British Columbia and the University of California, San Francisco, by performing serial magnetic resonance imaging examinations near birth and again near term-equivalent age. After we adjusted for associated clinical factors, antenatal betamethasone was not associated with changes in cerebellar volume. Postnatal exposure to clinically routine doses of hydrocortisone or dexamethasone was associated with impaired cerebellar, but not cerebral, growth. Alterations in treatment after preterm birth, particularly glucocorticoid exposure, may help to decrease risk for adverse neurological outcome after preterm birth.
Departments of Neurology and Pediatrics, University of California, San Francisco, San Francisco, CA 94143, USA. emily.tam@ucsf.edu
Emily W Y
EW
Tam
Vann
V
Chau
Donna M
DM
Ferriero
A James
AJ
Barkovich
Kenneth J
KJ
Poskitt
Colin
C
Studholme
Eric D-Y
ED
Fok
Ruth E
RE
Grunau
David V
DV
Glidden
Steven P
SP
Miller
D002531:Cerebellum / Q000187:drug effects* / Q000254:growth & development* / Q000473:pathology; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008279:Magnetic Resonance Imaging; D008297:Male
D005938:Glucocorticoids