Maslinic acid derivatives induce significant apoptosis in b16f10 murine melanoma cells.
Maslinic acid (2α,3β-dihydroxyolean-12-en-28-oic acid), a natural dihydroxylated pentacyclic triterpene acid isolated from olive-pressing residues, has been investigated together with some of its derivatives regarding the induction of apoptosis in B16F10 melanoma cells. Some of the compounds tested are described in this work, but others come from previous studies. Ten of these derivatives induce over 80% of apoptosis, clearly promoting cell death in B16F10 melanoma. By contrast, the induction cell death through necrosis was very slightly significant with these compounds. These results indicate that maslinic acid derivatives are promising chemopreventive and chemotherapeutic agents.
Departamento de Quimica Organica, Facultad de Ciencias, Universidad de Granada, Fuentenueva, s/n, 18071-Granada, Spain. aparra@ugr.es
Andres
A
Parra
Francisco
F
Rivas
Samuel
S
Martin-Fonseca
Andres
A
Garcia-Granados
Antonio
A
Martinez
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D008545:Melanoma / Q000188:drug therapy*; D051379:Mice; D031658:Olea / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D009828:Oleanolic Acid / Q000031:analogs & derivatives
D000970:Antineoplastic Agents; D014315:Triterpenes; C412811:maslinic acid; D009828:Oleanolic Acid