Elevation of prostaglandin E2 in lung cancer patients with digital clubbing.
To test the hypothesis that digital clubbing in patients with lung cancer reflects elevated systemic levels of prostaglandin E2 (PGE2), we quantified levels of the major urinary PGE2 metabolite in 29 patients with lung cancer with or without clubbing. We found that digital clubbing was associated with markedly elevated urinary levels of PGE2 metabolite. These findings highlight a potential role for PGE2 in the pathogenesis of digital clubbing. Furthermore, this result identifies a lung cancer subpopulation that may uniquely benefit from cyclooxygenase inhibition.
Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin. Electronic address: kozak@humonc.wisc.edu.
Kevin R
KR
Kozak
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee.
Ginger L
GL
Milne
Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Søren M
SM
Bentzen
Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts.
Torunn I
TI
Yock
D000230:Adenocarcinoma / Q000150:complications* / Q000473:pathology / Q000652:urine; D015232:Dinoprostone / Q000652:urine*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000473:pathology / Q000652:urine; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000209:etiology* / Q000652:urine; D011379:Prognosis; D011446:Prospective Studies
D015232:Dinoprostone