Targeting nitrosative stress for neurovascular protection: new implications in brain diseases.
Nitric oxide/peroxynitrite signaling is associated with manifold neurovascular pathogenic cascades that lead to neurodegenerative diseases, including ischemic stroke, Alzheimer's disease, and vascular dementia. Considerable evidence suggests that reactive nitrogen species as mediators of nitrosative stress could damage biomolecules and subsequently facilitate the breakdown of the highly-structured cellular machinery. Herein, we focus on nitrosative stress signaling, which is intimately associated with endothelial cell injury and blood-brain barrier damage in stroke and neurodegenerative diseases. Unraveling the detrimental role of nitrosative stress signaling in initiating and driving neurovascular pathogenesis may lead to the development of novel vasoprotective strategies via restorative therapies for brain diseases.
Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, Zhejiang University, Hangzhou, China.
Rong-Rong
RR
Tao
Yue-Long
YL
Ji
Ying-Mei
YM
Lu
Kohji
K
Fukunaga
Feng
F
Han
D000818:Animals; D001927:Brain Diseases / Q000188:drug therapy* / Q000378:metabolism*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000188:drug therapy* / Q000378:metabolism*; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D015538:Nitrosation / Q000187:drug effects; D026361:Reactive Nitrogen Species / Q000378:metabolism*
D018696:Neuroprotective Agents; D026361:Reactive Nitrogen Species