[Clinical versatility of the inflammatory pseudotumor in urology].
OBJECTIVE
The inflammatory pseudotumor is a rare lesion, having benign behavior and some histological heterogeneity that appears in the genitourinary tract. A series of urogenital inflammatory pseudotumors are reviewed with emphasis on their clinicopathological and immunohistochemical characteristics.


METHODS
A retrospective study the causistics treated between January 1981 in December 2010 was performed. It identified the cases of inflammatory pseudotumor with urogenital localization. The variables age, gender, symptoms, topography, treatment and anatomopathological and immunohistochemical characteristics of each case were analyzed.


RESULTS
A total of 8 cases of the urogenital-located inflammatory pseudotumor are described. Of these, 6 were located in the bladder, one in the kidney and one in the epididymis. Mean age of the patients was 46.75 (± 19.84) years. Tumor presentation symptoms were macroscopic hematuria, single symptom or accompanied by symptoms of the lower urinary tract and inguinoscrotal mass. In regards to treatment in the cases of bladder localization, transuretheral ± cystectomy were performed. In the case of kidney localization, treatment was made by means of pyelotomy and exeresis, and in the case of epididymis localization, simple exeresis was performed. The anatomopathological study showed inflammatory pseudotumor in every cases, having a mesenchymal and myxoid appearance, with fusiform cells of eosinophil cytoplasm, with presence of frequent inflammatory cells. The most common immunohistochemical pattern shows positivity for the muscle-specific actin (HHF-35), vimentin and negativity for protein S-100. ALK-1 was positive and 87.5% of the cases.


CONCLUSIONS
The inflammatory pseudotumor is a condition having good prognosis which, when there is a good histopathological and immunohistochemical diagnosis, every urologist should recognize and distinguish in order to carry out as conservative a surgical treatment as possible.
Servicio de Urología, Hospital Universitario de Getafe, Fundación para la Investigación Biomédica del Hospital Universitario de Getafe, Universidad Europea de Madrid, Madrid, España.
F
F
Lista
G
G
Andrés
E
E
Mateo
F I
FI
Camacho
J M
JM
Rodríguez-Barbero
J C
JC
Angulo
D000199:Actins / Q000032:analysis; D030301:Activin Receptors, Type II / Q000032:analysis; D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers; D015653:Cystectomy; D003937:Diagnosis, Differential; D003952:Diagnostic Imaging; D004822:Epididymis / Q000473:pathology / Q000601:surgery; D005260:Female; D005832:Genital Diseases, Male / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D006104:Granuloma, Plasma Cell / Q000175:diagnosis / Q000453:epidemiology* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D006801:Humans; D007633:Keratins / Q000032:analysis; D007674:Kidney Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012509:Sarcoma / Q000175:diagnosis; D013030:Spain / Q000453:epidemiology; D001745:Urinary Bladder Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D014746:Vimentin / Q000032:analysis
D000199:Actins; D015415:Biomarkers; D014746:Vimentin; D007633:Keratins; C425364:ACVRL1 protein, human; D030301:Activin Receptors, Type II