Contraceptive failure of etonogestrel implant in patients treated with antiretrovirals including efavirenz.
Contraception for HIV-positive women is a complex issue. Although the use of condoms is recommended, complementary methods of contraception are often prescribed. Antiretroviral therapy can lead to drug interactions and modify the efficacy of hormonal contraception. Two unintended pregnancies suggest that etonogestrel implants should be used with caution in patients on efavirenz.
Maternité, Hôpital Necker-Enfants Malades, 75015 Paris Descartes, France.
Nadia
N
Leticee
Jean-Paul
JP
Viard
Amina
A
Yamgnane
Marina
M
Karmochkine
Alexandra
A
Benachi
D000328:Adult; D000480:Alkynes; D044966:Anti-Retroviral Agents / Q000009:adverse effects* / Q000627:therapeutic use; D048588:Benzoxazines / Q000009:adverse effects* / Q000627:therapeutic use; D017280:Condoms; D003271:Contraceptive Agents, Female / Q000008:administration & dosage*; D003521:Cyclopropanes; D017135:Desogestrel / Q000008:administration & dosage*; D004347:Drug Interactions; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D011247:Pregnancy; D049168:Pregnancy, Unplanned
D000480:Alkynes; D044966:Anti-Retroviral Agents; D048588:Benzoxazines; D003271:Contraceptive Agents, Female; D003521:Cyclopropanes; C044815:etonogestrel; D017135:Desogestrel; C098320:efavirenz