Suicidality in temporal lobe epilepsy: measuring the weight of impulsivity and depression.
OBJECTIVE
The aim of the work described here was to measure the role of psychopathological features, specifically impulsivity and depression, in suicidality in patients with temporal lobe epilepsy (TLE).


METHODS
Neuropsychiatric evaluation of 66 outpatients with TLE was performed with the following instruments: a structured clinical interview (Mini International Neuropsychiatric Interview Plus), the Barratt Impulsiveness Scale, the Hamilton Anxiety Scale, the Beck Depression Inventory, and the Brief Psychiatric Rating Scale.


RESULTS
A current Axis I psychiatric diagnosis, mainly mood and anxiety disorders, was assigned to 37 subjects (56.1%) Presence of suicide risk was identified in 19 patients (28.8%), and 14 (21.2%) had attempted suicide. Frequency of seizures (P=0.012), current major depression (P=0.001), and motor impulsivity (P=0.005) were associated with suicide risk on univariate analysis. Logistic regression stressed the main relevance of major depression (OR=12.82, 95% CI=2.58-63.76, P=0.002) and motor impulsivity (OR=1.21, 95% CI=1.06-1.38, P=0.005) to suicide risk.


CONCLUSIONS
Depression has a major influence on suicidality in epilepsy. Motor impulsivity is also relevant and may be an important component of depression in TLE associated with suicide risk.
Neuropsychiatric Unit, Neurology Division, School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. norgleids@hotmail.com
Guilherme Nogueira M
GN
de Oliveira
Arthur
A
Kummer
João Vinícius
JV
Salgado
Gerardo Maria de Araújo
GM
Filho
Anthony S
AS
David
Antônio Lúcio
AL
Teixeira
D000328:Adult; D000368:Aged; D003863:Depression / Q000175:diagnosis* / Q000209:etiology; D004833:Epilepsy, Temporal Lobe / Q000150:complications* / Q000523:psychology*; D005260:Female; D006801:Humans; D007175:Impulsive Behavior / Q000175:diagnosis* / Q000209:etiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010045:Outpatients; D011569:Psychiatric Status Rating Scales; D013405:Suicide / Q000523:psychology*; D014894:Weights and Measures; D055815:Young Adult