[Hypoxic preconditioning as novel approach to prophylaxis of ischemic and reperfusion damage of brain and heart].
Analysis of published data indicates that delayed hypoxic preconditioning essentially increases a cardiac and brain tolerance to ischemia-reperfusion. There are no experimental data in the literature on the neuroprotective effect of early hypoxic preconditioning in vivo. Clinical observations indicated that early hypoxic preconditioning exerts cardioprotective and neuroprotective effects. The single works testify that cardioprotective effect of delayed hypoxic preconditioning depend on the activation of inducible NO-synthase, KATP-channels and KCa-channels. Neuroprotective effect of hypoxic preconditioning is a consequence: (1) erythropoietin receptor stimulation and (2) an elevation of activity of PI3-Akt and ERK1/2 kinases. The supposed end effector of brain hypoxic preconditioning is MPT-pore.
L N
LN
Maslov
Iu B
IuB
Lishmanov
T V
TV
Emel'ianova
D A
DA
Prut
F
F
Kolar
A G
AG
Portnichenko
Iu K
IuK
Podoksenov
I G
IG
Khaliulin
H
H
Wang
J M
JM
Pei
D000818:Animals; D002545:Brain Ischemia / Q000517:prevention & control*; D006801:Humans; D019194:Ischemic Preconditioning / Q000379:methods*; D017202:Myocardial Ischemia / Q000517:prevention & control*; D015427:Reperfusion Injury / Q000517:prevention & control*