Different metabolites of human hepatotoxic pyrazolopyrimidine derivative 5-n-butyl-pyrazolo[1,5-a]pyrimidine produced by human, rat and monkey cytochrome P450 1A2 and liver microsomes.
Research and Development Center, Otsuka Pharmaceutical Factory, Inc., Naruto, Tokushima, Japan.
Shunji
S
Kuribayashi
Yasuhiro
Y
Uno
Shinsaku
S
Naito
Hiroshi
H
Yamazaki
D000818:Animals; D019388:Cytochrome P-450 CYP1A2 / Q000378:metabolism*; D000882:Haplorhini; D006801:Humans; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D011720:Pyrazoles / Q000378:metabolism*; D011743:Pyrimidines / Q000378:metabolism*; D051381:Rats; D013045:Species Specificity
C547858:5-n-butyl-pyrazolo(1,5-a)pyrimidine; D011720:Pyrazoles; D011743:Pyrimidines; D019388:Cytochrome P-450 CYP1A2