Quality of life in 1931 adult patients with epilepsy: seizures do not tell the whole story.
OBJECTIVE
The aim of the work described here was to characterize quality of life (QOL) and its determinants in a large cohort of adult patients with epilepsy.


METHODS
Validated measures reflecting disease severity and psychosocial functioning were electronically collected on all outpatients seen during 2009. Multivariate regression adjusting for repeated measures identified determinants of QOL, as defined by the Quality of Life in Epilepsy Questionnaire-10 (QOLIE-10).


RESULTS
Seven thousand seven hundred eighty-four visits from patients with epilepsy were identified. The questionnaire completion rate was 77%, yielding 5960 records corresponding to 1931 individual patients for analysis. Following multivariate modeling, the two most clinically significant QOL predictors were seizure severity (mean QOLIE-10 score=28.8 if LSSS>40 vs 19.2 otherwise) and depression (mean QOLIE-10 score=31.7 if PHQ-9≥10 vs 19.3 otherwise).


CONCLUSIONS
Optimizing quality of life in patients with epilepsy requires an approach that extends beyond controlling seizures. Collection of validated health status measures improving patient management is possible within the setting of routine clinical care.
Epilepsy Center, Cleveland Clinic, Cleveland, OH 44124, USA. jehil@ccf.org
Lara
L
Jehi
George
G
Tesar
Nancy
N
Obuchowski
Eric
E
Novak
Imad
I
Najm
D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004827:Epilepsy / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology* / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology / Q000523:psychology; D008875:Middle Aged; D011788:Quality of Life; D012044:Regression Analysis; D012189:Retrospective Studies; D012640:Seizures / Q000503:physiopathology / Q000523:psychology; D011795:Surveys and Questionnaires; D055815:Young Adult
D000927:Anticonvulsants