Rhodium-catalysed enantioselective synthesis of 4-arylchroman-2-ones.
The rhodium-catalysed enantioselective 1,4-addition of organoboron reagents to arylidene Meldrum's acids as acceptors, allows convenient access to 4-arylchroman-2-ones with good to excellent levels of enantioselectivity. The use of silyl-protected dioxaborinanes as donors was found to be advantageous to achieving good yields of product under anhydrous conditions.
Department of Chemistry, University of Bath, Bath, UK BA2 7AY.
Joseph C
JC
Allen
Gabriele
G
Kociok-Köhn
Christopher G
CG
Frost