Synthesis of novel spin-labelled combretastatin A-4 derivatives as potential antineoplastic agents.
Four novel spin-labelled combretastatin A-4 (CA-4) analogues were first synthesised in quantitative yield by reacting CA-4 with the corresponding nitroxyl radical. Their cytotoxic activities against A-549 (human lung cancer) and HePG-2 (human liver cancer) in vitro were evaluated, and the results indicated that these derivatives were more cytotoxic than the clinical drug irinotecan.
School of Pharmacy, Lanzhou University, Lanzhou 730000, PR China.
Xiao-Jing
XJ
Li
Liu
L
Yang
Ying-Qian
YQ
Liu
Chong
C
Li
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D056945:Hep G2 Cells; D006801:Humans; D015394:Molecular Structure; D013267:Stilbenes / Q000737:chemistry*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D013267:Stilbenes; C058728:fosbretabulin