[Comparison of clinicopathological features and prognosis in familial and sporadic gastric cancer].
OBJECTIVE
To analyze the clinicopathological characteristics and prognosis of familial gastric cancer and to improve the treatment outcome.


METHODS
Clinical data of 67 patients with familial gastric cancer and 820 patients with sporadic gastric cancer in the Second Affiliated Hospital of Dalian Medical University from 1995 to 2005 were retrospectively analyzed.


RESULTS
Compared to sporadic gastric cancer, the percentage of familial gastric cancer patients less than 45 years old was higher (34.3% vs. 14.6%). Early gastric cancer(23.9% vs. 13.8%), diffuse gastric cancer(79.1% vs. 29.0%), and lymph node metastasis (91.0% vs. 70.9%) were more common in patients with familial cancer(P<0.05). The 5-year survival rate of familial gastric cancer patients was lower than that of patients with sporadic gastric cancer(20.5% vs. 45.1%)(P<0.05).


CONCLUSIONS
Familial gastric cancer has characteristics of younger onset age, advanced disease staging, higher positive lymph node ratio and poorer prognosis. Therefore, early diagnosis should be emphasized in the management of familial gastric cancer.
Department of General Surgery, Dalian Medical University, Dalian, China. mazhenhai2004@163.com
Zhen-hai
ZH
Ma
Qiao-zhen
QZ
Ren
Yong-fu
YF
Zhao
Guang-ming
GM
Xing
Guang-yi
GY
Shi
Hong-sheng
HS
Yang
Xiao-feng
XF
Tian
Dong-qiu
DQ
Dai
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery*; D015996:Survival Rate