Overexpression of G6PD is associated with poor clinical outcome in gastric cancer.
This study aims to investigate the expression and significance of glucose-6-phosphate dehydrogenase (G6PD) in human gastric cancer progression and prognosis. Using immunohistochemistry and real-time RT-PCR assay, we identified abnormally elevated expression of G6PD in gastric cancer tissues compared to paired normal stomach mucosa tissues in 24 patients (p < 0.05). In order to investigate the correlations between G6PD and the clinicopathological features of gastric cancer, the expression of G6PD in 167 patients with gastric cancer were detected by immunohistochemistry, and the results showed that overexpression of G6PD was associated with the size of tumor (p = 0.039), depth of invasion (p = 0.039), lymph node metastasis (p = 0.044), distant metastasis (p = 0.003), TNM stage (p = 0.030), and survival rate (p = 0.010). Further, Cox multivariates analysis indicated that G6PD expression level was an independent prognostic factor for patients after radical resection (p = 0.013). In conclusion, overexpression of G6PD is closely related to progression of gastric cancer, and might be regarded as an independent predictor of poor prognosis for gastric cancer.
Department of General Surgery, Xiangya Hospital, Central South University, Xiangya Road, Changsha, 410008 Hunan, China.
Jixu
J
Wang
Weijie
W
Yuan
Zhikang
Z
Chen
Shaobin
S
Wu
Jinxiang
J
Chen
Jie
J
Ge
Futao
F
Hou
Zihua
Z
Chen
D000328:Adult; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000096:biosynthesis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000401:mortality / Q000473:pathology*; D055815:Young Adult
D014408:Biomarkers, Tumor; D005954:Glucosephosphate Dehydrogenase