Evidence for functional trace amine associated receptor-1 in normal and malignant B cells.
Following the observation that dopaminergic components are present in normal and malignant B cells, we now provide evidence that they additionally express the functionally related trace amine-associated receptor-1 (TAAR1). Immunodetectable TAAR1 was found in lines derived from a broad range of B-cell malignancy; and in tonsillar B cells, particularly when activated. L3055 Burkitt's lymphoma cells were shown to respond to prototypical TAAR1 agonists in cytotoxicity assays with features of apoptotic death evident; normal B cells were somewhat less sensitive to the agonists. These data raise the possibility that TAAR1 may have therapeutic relevance to leukemia, lymphoma, and wider B-cell pathologies.
School of Immunity & Infection, The Medical School, Birmingham, UK.
Agata M
AM
Wasik
Mark J
MJ
Millan
Thomas
T
Scanlan
Nicholas M
NM
Barnes
John
J
Gordon
D017209:Apoptosis / Q000187:drug effects; D001402:B-Lymphocytes / Q000378:metabolism*; D015153:Blotting, Western; D002051:Burkitt Lymphoma / Q000378:metabolism* / Q000473:pathology; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D004298:Dopamine / Q000378:metabolism; D005434:Flow Cytometry; D006801:Humans; D014066:Palatine Tonsil / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000819:agonists* / Q000378:metabolism*; D000095383:Trace Amine-Associated Receptors
D004298:Dopamine; D043562:Receptors, G-Protein-Coupled; D000095383:Trace Amine-Associated Receptors