Detoxification of high-dose zolpidem using cross-titration with an adequate equivalent dose of diazepam.
BACKGROUND
There have been numerous case reports of zolpidem abuse and dependence in the recent decade, giving rise to a focus on adverse withdrawal events such as seizure. No standard detoxification regimen has been proposed to date, despite the similarity of effects of zolpidem and benzodiazepines at high doses.


METHODS
We describe the results, in a 53-year-old female patient, of undergoing three different zolpidem detoxification programs.


CONCLUSIONS
Because of her experiences, we recommend using the cross-titration strategy with an adequate equivalent dose of diazepam.
Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan.
Shao-Chien
SC
Chen
Hsi-Chung
HC
Chen
Shih-Cheng
SC
Liao
Mei-Chih Meg
MC
Tseng
Ming-Been
MB
Lee
D000328:Adult; D000368:Aged; D003975:Diazepam / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage* / Q000506:poisoning*; D008658:Inactivation, Metabolic; D008297:Male; D008875:Middle Aged; D011725:Pyridines / Q000008:administration & dosage* / Q000506:poisoning*; D000077334:Zolpidem
D006993:Hypnotics and Sedatives; D011725:Pyridines; D000077334:Zolpidem; D003975:Diazepam