Uterine fibroids and risk for complications following second-trimester amniocentesis.
OBJECTIVE
To compare the abortion rate and preterm premature rupture of membranes (PPROM) after amniocentesis in women who have undergone antibiotic prophylaxis with uterine fibroids and control.


METHODS
Retrospective study using the Antibiotic Prophylaxis before Second-Trimester Genetic Amniocentesis trial database carried out between January 1999 and December 2005 at the Artemisia Fetal-Maternal Medical Center (Rome, Italy). All women underwent antibiotic prophylaxis before amniocentesis. A follow-up within 4 weeks from the procedure was available.


RESULTS
A total of 2,497 of 21,219 (11.8%) women with uterine fibroids were identified. The rate of abortion was 2 of 2,497 (0.08%) in women with fibroids and 4 of 18,722 (0.03%) in women without fibroids (p = 0.42). The rate of PPROM was 4 of 2,497 (0.16%) in women with fibroids and 10 of 18,722 (0.05%) in women without fibroids (p = 0.12).


CONCLUSIONS
The risk for abortion and PPROM does not increase in the presence of uterine fibroids in women who have undergone antibiotic prophylaxis.
Department of Prenatal Diagnosis, Artemisia Fetal-Maternal Medical Center, Rome, Italy. pietrocignini@fastwebnet.it
Pietro
P
Cignini
Luisa
L
Mobili
Laura
L
D'Emidio
Lucia
L
Mangiafico
Claudio
C
Coco
Claudio
C
Giorlandino
D000022:Abortion, Spontaneous / Q000453:epidemiology*; D000328:Adult; D000649:Amniocentesis; D019072:Antibiotic Prophylaxis; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000453:epidemiology*; D006801:Humans; D007889:Leiomyoma / Q000150:complications*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000453:epidemiology*; D011262:Pregnancy Trimester, Second; D012189:Retrospective Studies; D012307:Risk Factors; D014594:Uterine Neoplasms / Q000150:complications*