The level of cortical afferent inhibition in acute stroke correlates with long-term functional recovery in humans.
OBJECTIVE
Using transcranial magnetic stimulation, we investigated short-interval intracortical inhibition and short-latency afferent inhibition in acute ischemic stroke.


METHODS
We evaluated short-interval intracortical inhibition and short-latency afferent inhibition in the affected hemisphere and unaffected hemisphere in 16 patients and correlated electrophysiological parameters with outcome at 6 months.


RESULTS
Affected hemisphere short-latency afferent inhibition was significantly reduced in patients, and short-latency afferent inhibition level correlated with functional outcome.


CONCLUSIONS
Reduced afferent inhibition in acute stroke correlates with long-term recovery.
Institute of Neurology, Universitá Cattolica, Rome, Italy. vdilazzaro@rm.unicatt.it
Vincenzo
V
Di Lazzaro
Paolo
P
Profice
Fabio
F
Pilato
Fioravante
F
Capone
Federico
F
Ranieri
Lucia
L
Florio
Cesare
C
Colosimo
Emanuele
E
Pravatà
Patrizio
P
Pasqualetti
Michele
M
Dileone
D000368:Aged; D000369:Aged, 80 and over; D019054:Evoked Potentials, Motor / Q000502:physiology; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008875:Middle Aged; D009044:Motor Cortex / Q000503:physiopathology; D009433:Neural Inhibition / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D020127:Recovery of Function / Q000502:physiology*; D020521:Stroke / Q000503:physiopathology*; D050781:Transcranial Magnetic Stimulation