Modular synthesis of supramolecular ureidopyrimidinone-peptide conjugates using an oxime ligation strategy.
A convenient method to prepare supramolecular bioconjugates in a facile and scalable manner is by a modular approach, whereby self-assembling units and peptides are coupled using oxime chemistry. We here report syntheses of bioactive ureidopyrimidinone-based peptide conjugates, and their resultant self-assembly into fibrous structures.
Institute for Complex Molecular Systems, and Laboratory of Chemical Biology, Eindhoven University of Technology (TU/e), PO Box 513, 5600 MB, Eindhoven, The Netherlands.
Roxanne E
RE
Kieltyka
Maartje M C
MM
Bastings
Geert C
GC
van Almen
Pol
P
Besenius
Erwin W L
EW
Kemps
Patricia Y W
PY
Dankers
D046911:Macromolecular Substances / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D010091:Oximes / Q000737:chemistry*; D010316:Particle Size; D010455:Peptides / Q000737:chemistry*; D011744:Pyrimidinones / Q000737:chemistry*; D013499:Surface Properties
D046911:Macromolecular Substances; D010091:Oximes; D010455:Peptides; D011744:Pyrimidinones