Gradual declination of IGF-1 over a year after transsphenoidal adenomectomy of GH producing pituitary adenomas.
To know the longitudinal shift of blood IGF-1 of cured acromegaly, we conducted retrospective survey of changes in blood IGF-1 over two years, which has not been previously investigated.  Blood IGF-1 levels were measured for longer than 2 years after TSS in 37 patients whose nadir GH during postoperative oral glucose tolerance test (OGTt) was under 1 ng/mL.  Blood IGF-1 very gradually declined after three months; 230.6 (mean) ng/mL at 3-12 months, 202.3 ng/mL at 12-24 months, and 198.6 ng/mL at 24-36 months.  Their SD values, calculated based on standard IGF-1 values of age- and sex-matched Japanese population, also slowly decreased after three months; 1.69 (mean) at 3-12 months, 1.23 at 12-24 months, and 1.12 at 24-36 months.  Very slow decrease of the IGF-1 levels continued beyond the first several months and even the first year after TSS.  The declination of values is greater than that associated with aging.  This declination may be at least partially a reflection of the slow decrease and late normalization of GH secretion.
Department of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8520, Japan.
Shingo
S
Fujio
Hiroshi
H
Tokimura
Ryosuke
R
Hanaya
Hirofumi
H
Hirano
Kazunori
K
Arita
Shunji
S
Yunoue
Manoj
M
Bohara
Hiroshi
H
Arimura
Yasuyuki
Y
Kinoshita
Atsushi
A
Tominaga
D000172:Acromegaly / Q000601:surgery*; D000236:Adenoma / Q000097:blood* / Q000601:surgery; D000328:Adult; D000368:Aged; D005260:Female; D019382:Human Growth Hormone / Q000378:metabolism*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000097:blood* / Q000601:surgery; D012189:Retrospective Studies
D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I