Sweet's syndrome with postinflammatory elastolysis and Takayasu arteritis in a child: a case report and literature review.
Sweet's syndrome (SS) is an uncommon condition characterized by recurrent painful cutaneous inflammatory eruptions. It is rare in childhood and has a broad range of extracutaneous manifestations. We describe a child presenting with SS and postinflammatory elastolysis who subsequently developed aortitis complicated by aortic dilatation requiring surgical intervention. Histologic features of the aorta were consistent with Takayasu arteritis (TA). Our case and previously reported cases of pediatric SS complicated by aortitis all demonstrate striking clinical similarities in that all have been associated with postinflammatory elastolysis of involved skin and aneurysmal dilation of the thoracic aorta. We propose that TA should be considered one of the disease associations of SS when complicated by postinflammatory elastolysis and that early referral for cardiovascular screening be considered in this group of patients.
Department of Dermatology, Royal Children's Hospital, Melbourne, Australia.
Ellen H
EH
Ma
Jonathan D
JD
Akikusa
Duncan
D
MacGregor
Jessica
J
Ng
John C
JC
Su
D003520:Cyclophosphamide / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D011859:Radiography; D016463:Sweet Syndrome / Q000000981:diagnostic imaging / Q000473:pathology*; D013625:Takayasu Arteritis / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
D003520:Cyclophosphamide; D008727:Methotrexate