[Indoor air guide values for phenol].
The German Working Group on Indoor Guidelines of the Federal Environment Agency and the States´ Health Authorities is issuing indoor air guide values to protect public health. For health evaluation of phenol in indoor air a qualified working-place study emphasizing the POD hemo- and hepatotoxicity as well as results of a limited inhalation-study which underline neurological effects on rats were used. The Working Group assessed a lowest observed adverse effect level of 21 mg Phenol/m3 in the working-place study and 100 mg Phenol/m3 in the animal-based study. Both toxicological derivatives come to the same result but the working-place study was preferred. By applying a factor of 10 for interindividual variability, a factor of 4.2 for the different exposing-time of workers and usual population and a modifying factor of 2 regarding children a health hazard guide value (RW II) of 0.2 mg phenol/m3 is obtained. A health precaution guide value of 0.02 mg phenol/m3 is recommended.
D000280:Administration, Inhalation; D000284:Administration, Oral; D000328:Adult; D016902:Air Pollution, Indoor / Q000032:analysis*; D000818:Animals; D002648:Child; D004202:Disinfectants / Q000493:pharmacokinetics / Q000633:toxicity; D005260:Female; D005858:Germany; D006168:Guinea Pigs; D006801:Humans; D008658:Inactivation, Metabolic / Q000502:physiology; D008253:Macaca mulatta; D008297:Male; D008452:Maximum Allowable Concentration; D008657:Metabolic Clearance Rate / Q000502:physiology; D051379:Mice; D019800:Phenol / Q000493:pharmacokinetics / Q000633:toxicity; D051381:Rats; D012756:Sheep; D012869:Skin Absorption / Q000502:physiology; D013552:Swine
D004202:Disinfectants; D019800:Phenol