[Palmar-plantar erythrodysaesthesia syndrome local cold prevention].
OBJECTIVE
to evaluate the role of local cold applied to the tips on the prevention of palmar-plantar erythrodysaesthesia (PPE) caused by pegylated liposomal doxorubicin (PLD).


METHODS
from may 2006 to june 2009, 8 patients with cutaneous T-cell lymphoma mycosis fungoides type were treated with PLD. The median age was 56 years and was administered a total of 63 cycle, with an average of 7.87 cycle per person, with a dose of PLD 20 mg/m2 every 2 weeks. All patients had premedication with dexamethasone, ondasetron and pyridoxine. At the time all were given prophylaxis with local cold for an hour


RESULTS
only one patient had grade 4 PPE (12.5%), which appeared after the first cycle, subsequent can manage a total of 10. In absolute terms was recorded EPP grade 4 only 1.58% of cycles administered (1/63). In the remaining patients there was no degree of EPP.


CONCLUSIONS
this paper demonstrates the effectiveness of several preventive measures (pyridoxine, corticosteroid and local cold) in the prevention of the PPE.
Servicio de Dermatología del Hospital Universitario 12 de Octubre.
María Paz
MP
Serrano Fernández
María Jesús
MJ
Gutiérrez Vilella
Angeles
A
Pérez Martín-Palanco
Francisco
F
Vanaclocha Sebastián
Luis
L
Cabezón Gutiérrez
D017679:Cryotherapy; D005260:Female; D060831:Hand-Foot Syndrome / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged