The SNP c.1326T>G in the non-SMC condensin I complex, subunit G (NCAPG) gene encoding a p.Ile442Met variant is associated with an increase in body frame size at puberty in cattle.
Recently, we had located a bovine carcass weight QTL, CW-2, to a 591-kb interval on BTA6 and have identified the SNP c.1326T>G in the NCAPG (non-SMC condensin I complex, subunit G) gene that leads to the amino acid change p.Ile442Met in the NCAPG protein, which is a candidate causative variation. Here, we examined the association of the NCAPG:c.1326T>G locus with linear skeletal measurements of growth-associated traits during adolescence, which is a period of intensive growth, using two historically and geographically distant cattle populations: 792 Japanese Black steers and 161 F(2)  bulls of an experimental cross from Charolais and German Holstein. In both populations, the SNP NCAPG:c.1326T>G was associated with each component of body frame size: height, length and width at puberty. The associations of CW-2 with height- and length-associated traits were observed at an earlier growth period compared to the associations with thickness- and width-associated traits, indicating that the primary effect of the CW-2 QTL may possibly be exerted on skeletal growth. The significant associations of the NCAPG:c.1326T>G locus with growth-associated skeletal measurements are similar to the effects of the syntenic region on human chromosome 4 that are associated with adult height in humans, supporting the hypothesis that CW-2 is analogous to the human locus and pointing to a conserved growth-associated locus or chromosomal region present in both species.
Cattle Breeding Development Institute of Kagoshima Prefecture, Osumi, So, Kagoshima, Japan.
K
K
Setoguchi
T
T
Watanabe
R
R
Weikard
E
E
Albrecht
C
C
Kühn
A
A
Kinoshita
Y
Y
Sugimoto
A
A
Takasuga
D019943:Amino Acid Substitution; D000818:Animals; D049628:Body Size; D002417:Cattle / Q000235:genetics* / Q000254:growth & development* / Q000502:physiology; D018797:Cell Cycle Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012741:Sexual Maturation
D018797:Cell Cycle Proteins