Candida albicans developmental regulation: adenylyl cyclase as a coincidence detector of parallel signals.
In the healthy individual, Candida albicans is frequently found as a harmless commensal residing in the gastrointestinal tract. However, in the compromised patient, C. albicans may invade the body and cause disease that is associated with poor prognosis and high mortality. The C. albicans adenylyl cyclase, Cyr1, which is required for virulence in animal models, regulates three developmental programs, including invasive filamentous growth, phenotypic switching to a mating-competent cell type, and biofilm formation. Evidence suggests that Cyr1 controls these phenotypes in response to various environmental cues that are present within microbial populations. Additionally, C. albicans secretes an autoregulatory molecule, farnesol, which was recently shown to directly inhibit Cyr1 activity. Below, we summarize recent advances in our understanding of Cyr1-regulated development and discuss the multiple inputs known to positively and negatively regulate cAMP synthesis. We discuss the possibility that Cyr1 acts as a coincidence detector that tightly regulates fungal development in response to parallel environmental stimuli, and highlight ways in which this might occur.
Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, United States. deborah.a.hogan@dartmouth.edu
Deborah A
DA
Hogan
Fritz A
FA
Muhlschlegel
D000067956:Adenylyl Cyclase Inhibitors; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002176:Candida albicans / Q000201:enzymology* / Q000254:growth & development / Q000378:metabolism / Q000502:physiology*; D004791:Enzyme Inhibitors / Q000378:metabolism; D005204:Farnesol / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D006801:Humans; D010641:Phenotype; D015398:Signal Transduction; D013312:Stress, Physiological; D014774:Virulence; D037521:Virulence Factors / Q000037:antagonists & inhibitors / Q000378:metabolism*
D000067956:Adenylyl Cyclase Inhibitors; D004791:Enzyme Inhibitors; D037521:Virulence Factors; D005204:Farnesol; D000262:Adenylyl Cyclases