Biomimetic synthesis of chiral erbium-doped silver/peptide/silica core-shell nanoparticles (ESPN).
Peptide-modified silver nanoparticles have been coated with an erbium-doped silica layer using a method inspired by silica biomineralization. Electron microscopy and small-angle X-ray scattering confirm the presence of an Ag/peptide core and silica shell. The erbium is present as small Er(2)O(3) particles in and on the silica shell. Raman, IR, UV-Vis, and circular dichroism spectroscopies show that the peptide is still present after shell formation and the nanoparticles conserve a chiral plasmon resonance. Magnetic measurements find a paramagnetic behavior. In vitro tests using a macrophage cell line model show that the resulting multicomponent nanoparticles have a low toxicity for macrophages, even on partial dissolution of the silica shell.
BAM Federal Institute for Materials Research and Testing, Richard-Willstaetter-Str. 11, 12489, Berlin, Germany. alexandre.mantion@bam.de
Alexandre
A
Mantion
Philipp
P
Graf
Ileana
I
Florea
Andrea
A
Haase
Andreas F
AF
Thünemann
Admir
A
Mašić
Ovidiu
O
Ersen
Pierre
P
Rabu
Wolfgang
W
Meier
Andreas
A
Luch
Andreas
A
Taubert
D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D002460:Cell Line; D004871:Erbium / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D008264:Macrophages / Q000166:cytology / Q000378:metabolism*; D060328:Magnetic Phenomena; D053758:Nanoparticles / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D012822:Silicon Dioxide / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D012834:Silver / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D013057:Spectrum Analysis; D020349:Surface Plasmon Resonance / Q000379:methods*
D010455:Peptides; D012834:Silver; D012822:Silicon Dioxide; D004871:Erbium