Sector (partial) oculo(dermal) melanocytosis in 89 eyes.
OBJECTIVE
To describe sector (partial) involvement of the uvea with melanocytosis.


METHODS
Noninterventional, retrospective case series.


METHODS
A total of 89 eyes of 86 patients.


METHODS
Review of medical records, color photographs, and ultrasound images.


METHODS
Clinical features and relationship with uveal melanoma.


RESULTS
Approximately all patients were Caucasian (n = 83, 97%), and sector melanocytosis involved the right (n = 41, 46%) or left (n = 48, 54%) eye. The involved tissue included iris (n = 58, 65%), choroid (n = 48, 54%), and both iris and choroid (n = 17, 19%). The melanocytosis affected a mean of 6 clock hours of iris and 5 clock hours of choroid. Related melanocytosis involved the sclera (n = 39, 44%), eyelid (n = 4, 4%), temple (n = 4, 4%), scalp (n = 1, 1%), and palate (n = 1, 1%). Uveal melanoma was found at presentation in 7 patients (8%) and was multifocal in 2 of these patients. A comparison of eyes with versus without melanoma revealed clinically significant factors (odds ratio [OR] > 2) of male gender (71% vs. 43% [OR 3.36]); cutaneous/palate melanocytosis (14% vs. 7% [OR 2.11]); scleral melanocytosis heaviest in superior, temporal, or nasal quadrants (57% vs. 29% [OR 2.41, confidence interval, 2.24-3.92]); and any degree of choroidal melanocytosis (86% vs. 70% [OR 2.63]), particularly diffuse choroidal melanocytosis (29% vs. 16% [OR 3.85]). None of these factors reached statistical significance in this small cohort. Over a mean follow-up of 6 years, there was no metastatic event.


CONCLUSIONS
Ocular melanocytosis can be sectoral (partial), affecting only a mean of 5 to 6 clock hours of the uvea and can manifest melanoma within the melanocytosis region. There were no specific features of melanocytosis statistically related to the presence of melanoma.


BACKGROUND
The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Ocular Oncology Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. carol.shields@shieldsoncology.com
Carol L
CL
Shields
Anam
A
Qureshi
Arman
A
Mashayekhi
Chantel
C
Park
Neelema
N
Sinha
Felina
F
Zolotarev
Jerry A
JA
Shields
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008544:Melanocytes / Q000473:pathology*; D008545:Melanoma / Q000000981:diagnostic imaging / Q000473:pathology*; D008548:Melanosis / Q000473:pathology; D008875:Middle Aged; D012189:Retrospective Studies; D014463:Ultrasonography; D014604:Uveal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D044465:White People