Factors associated with crestal bone gain on single-tooth locking-taper implants: the effect of nonsteroidal anti-inflammatory drugs.
OBJECTIVE
To identify factors associated with crestal bone gain around single-tooth implants.


METHODS
A retrospective cohort study was conducted. More than 90 different local and systemic factors were documented. Descriptive statistics and univariate and multivariate mixed-effects regression models, adjusted for multiple implants in the same patient, were used to identify predictors of crestal bone gain after insertion of definitive restorations.


RESULTS
Eighty-one subjects who received 326 Bicon implants were followed for an average of 70.7 months. Eighty-one implants in 46 patients showed varying degrees of apparent bone gain over time. Variables associated with peri-implant bone gain in the first multivariate model were: type of opposing structure, tooth (P = .02); type of restoration, crown cemented on a prefabricated titanium abutment with a spherical base (P = .006); hydroxyapatite coating (P = .0005); implant size 5 x 8 mm (P = .02); and daily intake of nonsteroidal anti-inflammatory drugs (NSAIDs) (P =.04). NSAIDs remained significantly correlated to crestal bone gain in the second multivariate analysis; an implant was significantly more likely to gain bone if the patient was taking NSAIDs daily (P = .02), but this effect was specific to hydroxyapatite-coated implants (P = .01).


CONCLUSIONS
Daily doses of NSAIDs were correlated with a significant increase in crestal bone levels around single-tooth hydroxyapatite-coated implants following crown insertion.
Implant Dentistry Centre, Boston, Massachusetts, USA. rainieru@yahoo.com
Rainier A
RA
Urdaneta
Shadi
S
Daher
Joseph
J
Lery
Kimberly
K
Emanuel
Sung-Kiang
SK
Chuang
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000539:Alveolar Process / Q000000981:diagnostic imaging / Q000187:drug effects*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001672:Biocompatible Materials / Q000737:chemistry; D002484:Cementation; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D015331:Cohort Studies; D003442:Crowns; D000044:Dental Abutments; D059605:Dental Implant-Abutment Design; D019250:Dental Implants, Single-Tooth; D003764:Dental Materials / Q000737:chemistry; D017267:Dental Prosthesis Design; D019094:Dental Prosthesis, Implant-Supported; D004358:Drug Therapy; D017886:Durapatite / Q000737:chemistry; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010012:Osteogenesis / Q000187:drug effects*; D016300:Radiography, Bitewing; D012189:Retrospective Studies; D014025:Titanium / Q000737:chemistry; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; D003764:Dental Materials; D017886:Durapatite; D014025:Titanium