Epilepsy and the consciousness system: transient vegetative state?
Recent advances have shown much in common between epilepsy and other disorders of consciousness. Behavior in epileptic seizures often resembles a transient vegetative or minimally conscious state. These disorders all converge on the "consciousness system" -the bilateral medial and lateral fronto-parietal association cortex and subcortical arousal systems. Epileptic unconsciousness has enormous clinical significance leading to accidental injuries, decreased work and school productivity, and social stigmatization. Ongoing research to better understand the mechanisms of impaired consciousness in epilepsy, including neuroimaging studies and fundamental animal models, will hopefully soon enable treatment trails to reduce epileptic unconsciousness and improve patient quality of life.
Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA. hal.blumenfeld@yale.edu
Hal
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Blumenfeld
D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D001931:Brain Mapping; D003243:Consciousness / Q000502:physiology*; D003244:Consciousness Disorders / Q000175:diagnosis* / Q000209:etiology*; D004569:Electroencephalography; D004827:Epilepsy / Q000150:complications*; D006801:Humans; D059906:Neuroimaging / Q000379:methods; D011877:Radionuclide Imaging