The initial presentation of systemic lupus erythematosis with aplastic anemia successfully treated with rituximab.
Hematologic disorders are common in autoimmune diseases. First presentation of systemic lupus erythematosis with aplastic anemia is extremely rare. We report a patient with the diagnosis of secondary aplastic anemia associated with lupus. All routine medications were not effective. She received Rituximab and her response was satisfactory. Her hematologic parameters were within normal range until last follow-up, six months after therapy was initiated with Rituximab. Review of literature displayed 23 cases of acquired aplastic anemia secondary to systemic lupus erythematosis; however, this is the first time the new drug therapy was used for the treatment.
Department of Internal Medicine, Baqiyatallah University of Medical Sciences, Tehran, Islamic Republic of Iran.
Gholam-Hossein
GH
Alishiri
Amin
A
Saburi
Noushin
N
Bayat
Ali-Reza
AR
Saadat
Ehsan
E
Saburi
D000328:Adult; D000741:Anemia, Aplastic / Q000209:etiology*; D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use*; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000188:drug therapy*; D000069283:Rituximab; D016896:Treatment Outcome
D058846:Antibodies, Monoclonal, Murine-Derived; D018501:Antirheumatic Agents; D000069283:Rituximab