High-yielding oxidation of β-hydroxyketones to β-diketones using o-iodoxybenzoic acid.
The oxidation of β-hydroxyketones to β-diketones was systematically investigated. o-Iodoxybenzoic acid (IBX) was found to be efficient, operationally easy, and superior to other common oxidants. The reaction is suitable for milligram- to gram-scale oxidations.
Department of Chemistry, Oregon State University, 153 Gilbert Hall, Corvallis, Oregon 97331, USA.
Samuel L
SL
Bartlett
Christopher M
CM
Beaudry
D007462:Iodobenzenes / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism
D007462:Iodobenzenes; D007659:Ketones; C476101:o-iodoxybenzoic acid