Papillary thyroid carcinoma with nodular fasciitis-like stroma: a case report.
Papillary thyroid carcinoma (PTC) is the most frequently occurring malignant neoplasm of the thyroid gland and is known to have several morphologic variants. PTC with nodular fasciitis-like stroma (PTC-NFS) is one of the unusual variants of PTC, with only a few cases being reported in the literature. This neoplasm is characterized by extensive reactive stromal proliferation, which may occupy 60 to 80% of the tumor along with areas of a typical papillary carcinoma. We report a case of PTC-NFS and address the diagnostic difficulties posed by the condition's extensive reactive stromal proliferation. We also emphasize that when one encounters a fibroproliferative lesion of the thyroid, a diligent search should also be made for PTC to avoid diagnostic errors.
Department of Pathology, St. John's Medical College, Bangalore 560034, India. nandeeshbn@gmail.com
Bevinahalli N
BN
Nandeesh
Anuradha
A
Ananthamurthy
Yeliur K
YK
Inchara
Marjorie M
MM
Correa
Isha
I
Garg
D002277:Carcinoma; D002291:Carcinoma, Papillary; D049109:Cell Proliferation; D004848:Epithelium / Q000473:pathology; D005208:Fasciitis / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D017154:Stromal Cells / Q000473:pathology*; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000473:pathology*