Physical interpretation of mean local accumulation time of morphogen gradient formation.
The paper deals with a reaction-diffusion problem that arises in developmental biology when describing the formation of the concentration profiles of signaling molecules, called morphogens, which control gene expression and, hence, cell differentiation. The mean local accumulation time, which is the mean time required to reach the steady state at a fixed point of a patterned tissue, is an important characteristic of the formation process. We show that this time is a sum of two times, the conditional mean first-passage time from the source to the observation point and the mean local accumulation time in the situation when the source is localized at the observation point.
Mathematical and Statistical Computing Laboratory, Division of Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda, Maryland 20892, USA. berezh@mail.nih.gov
Alexander M
AM
Berezhkovskii
Stanislav Y
SY
Shvartsman
D000465:Algorithms; D004058:Diffusion; D008954:Models, Biological; D009024:Morphogenesis; D013997:Time Factors