[The changing epidemiology of extended spectrum β-lactamase-producing Klebsiella pneumoniae].
In the last two decades, Klebsiella pneumoniae demonstrated some characteristics of acquisition of plasmids coding extended spectrum β-lactamases (ESBL). The review data showed an increase in worldwide prevalence of ESBL and a temporal shift in the prevalence of ESBL types in K. pneumoniae during this last decade. CTX-M-15 seems to be the predominant ESBL type in K. pneumoniae in some parts of the world. The dissemination of several nosocomial CTX-M-15-producing K. pneumoniae clones was reported unlike the worldwide dissemination of a single virulent ST131 CTX-M-15 producing Escherichia coli clone. The diversity of plasmids carrying the bla(CTX-M-15) gene in K. pneumoniae suggested the frequent transfer of this gene between different replicons. The acquisition of the bla(CTX-M-15) gene by K. pneumoniae was probably occurred via horizontal transfer from E. coli.
Faculté de Pharmacie, Laboratoire des Maladies Transmissibles etSubstances Biologiquement Actives, LR99ES27, Monastir, Tunisie. elherid@yahoo.fr
Dalèle
D
Elhani
Leila
L
Bakir
Mahjoub
M
Aouni
D003428:Cross Infection / Q000453:epidemiology; D018740:Genetic Heterogeneity; D005843:Geography; D014943:Global Health / Q000706:statistics & numerical data / Q000639:trends; D006801:Humans; D007710:Klebsiella Infections / Q000453:epidemiology* / Q000378:metabolism / Q000635:transmission; D007711:Klebsiella pneumoniae / Q000201:enzymology / Q000235:genetics / Q000378:metabolism; D013997:Time Factors; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism
D001618:beta-Lactamases