Transcriptional repressors: shutting off gene expression at the source affects developmental dynamics.
Developmental networks feature genes interlinked by transcriptional activation and repression. A new study indicates that repressors can 'shut the door' to newly initiating polymerases, allowing longer target genes to produce latent transcripts after shorter genes have been effectively silenced.
Department of Biochemistry and Molecular Biology, and Program in Quantitative Biology, Michigan State University, East Lansing, MI 48824, USA. arnosti@msu.edu
David N
DN
Arnosti
D000818:Animals; D004257:DNA Polymerase II / Q000378:metabolism*; D004330:Drosophila / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D012097:Repressor Proteins / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*
D012097:Repressor Proteins; D014157:Transcription Factors; D004257:DNA Polymerase II