High disaccharide intake associates with atherogenic lipoprotein profile.
Increased plasma concentrations of small LDL particles denote an atherogenic lipoprotein phenotype (ALP) that is correlated with increased circulating TAG and reduced HDL-cholesterol. Principal component analyses of subfraction concentrations have previously been used in the Swedish population-based Malmö Diet and Cancer (MDC) cohort to identify three independent components, one pattern representing the ALP. The aim of the present study was to examine the associations between macronutrient intakes and the principal component representing the ALP. We examined 4301 healthy subjects (46-68 years old, 60 % women) at baseline in the MDC cohort. Dietary data were collected using a modified diet history method. Plasma lipoprotein subfractions were measured using a high-resolution ion mobility method. The principal component corresponding to the ALP was significantly associated with a higher intake of disaccharides, and inversely related to protein and alcohol consumption (P < 0·001 for all). The present findings indicate that the ALP may be improved by a low intake of disaccharides, and moderate intakes of protein and alcohol.
Department of Clinical Sciences - Malmö, Lund University, SE-205 02 Malmö, Sweden. emily.sonestedt@med.lu.se
Emily
E
Sonestedt
Elisabet
E
Wirfält
Peter
P
Wallström
Bo
B
Gullberg
Isabel
I
Drake
Joanna
J
Hlebowicz
Gunilla
G
Nordin Fredrikson
Bo
B
Hedblad
Jan
J
Nilsson
Ronald M
RM
Krauss
Marju
M
Orho-Melander
D000368:Aged; D000428:Alcohol Drinking; D050197:Atherosclerosis / Q000097:blood* / Q000209:etiology* / Q000517:prevention & control; D008076:Cholesterol, HDL / Q000097:blood; D015331:Cohort Studies; D004036:Diet, Atherogenic / Q000009:adverse effects*; D004044:Dietary Proteins / Q000008:administration & dosage; D004187:Disaccharides / Q000008:administration & dosage* / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D011446:Prospective Studies; D012307:Risk Factors; D013548:Sweden
D008076:Cholesterol, HDL; D004044:Dietary Proteins; D004187:Disaccharides; D008074:Lipoproteins; D008077:Lipoproteins, LDL