T-bet deficient mice exhibit resistance to stress-induced development of depression-like behaviors.
T-bet, a Th1-specific T-box transcription factor, regulates Th1 development by inducing endogenous Th1 cytokines and IFN-γ. This study was conducted to determine if T-bet knockout mice exhibit resistance to stress-induced development of depression-like behaviors. The T-bet knockout mice significantly reduced depressive-like behaviors provoked by repeated restraint stress in an elevated plus-maze test (EPM), tail suspension test (TST), and forced swim test (FST). Moreover, stress-induced elevations of the pro-inflammatory cytokines were attenuated in T-bet deficient group. These results suggest that T-bet directly mediated stress-induced depression. Therefore, understanding T-bet function during stress represents an additional treatment strategy for depression.
Department of Physiology, College of Oriental Medicine, Kyung-Hee University, #1 Hoeki-Dong, Dongdaemoon-gu, Seoul, Republic of Korea.
Soo-Jeong
SJ
Kim
Hyojung
H
Lee
Hye-Young
HY
Joung
Gihyun
G
Lee
Hye-jeong
HJ
Lee
Min-Kyu
MK
Shin
Sung-Hoon
SH
Kim
Insop
I
Shim
Hyunsu
H
Bae
D000818:Animals; D001007:Anxiety / Q000523:psychology; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000097:blood; D003863:Depression / Q000276:immunology* / Q000473:pathology / Q000523:psychology; D019417:Hindlimb Suspension / Q000523:psychology; D018836:Inflammation Mediators / Q000037:antagonists & inhibitors / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011897:Random Allocation; D012149:Restraint, Physical / Q000523:psychology; D013312:Stress, Physiological / Q000235:genetics / Q000276:immunology*; D020825:T-Box Domain Proteins / Q000172:deficiency* / Q000235:genetics; D000098815:T-bet Transcription Factor
D016207:Cytokines; D018836:Inflammation Mediators; D020825:T-Box Domain Proteins; D000098815:T-bet Transcription Factor