Fetal intracranial translucency and cisterna magna at 11 to 14 weeks : reference ranges and correlation with chromosomal abnormalities.
OBJECTIVE
To measure the intracranial translucency (IT) and the cisterna magna (CM), to produce reference ranges and to examine the interobserver and intraobserver variability of those measurements. To examine the possible association of IT with chromosomal abnormalities.


METHODS
Prospective study on pregnancies assessed at 11 to 14 weeks. IT was measured retrospectively in 17 cases with aneuploidy.


RESULTS
To produce reference ranges, 465 fetuses were used. IT and CM correlated linearly with crown-rump-length (CRL) and were independent of maternal demographic characteristics and biochemical indices. IT had a weak positive correlation with nuchal translucency. For IT the intraclass correlation coefficient was 0.88 for intraobserver variability and 0.83 for interobserver variability. For CM the intraclass correlation coefficient was 0.95 for intraobserver variability and 0.84 for interobserver variability. The IT multiple of the median was significantly increased in the chromosomally abnormal fetuses (1.02 for the normal and 1.28 for the chromosomally abnormal fetuses, Mann Whitney p < 0.001). IT multiple of the median was a significant predictor of chromosomal abnormality (Receiver Operator Characteristic curve analysis: Area under the curve = 0.86, CI=0.76-0.96, p<0.001).


CONCLUSIONS
Intracranial translucency and CM can be measured reliably at the 11 to 14 weeks examination and the measurements are highly reproducible. IT appears to be increased in fetuses with chromosomal abnormalities.
3rd Department of Obstetrics and Gynaecology, University of Athens, Athens, Greece.
I
I
Papastefanou
A P
AP
Souka
A
A
Pilalis
P
P
Panagopoulos
D
D
Kassanos
D002869:Chromosome Aberrations; D002946:Cisterna Magna / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D015588:Observer Variation; D011247:Pregnancy; D011446:Prospective Studies; D012016:Reference Values; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal