HLA and MICA genes in patients with tuberculosis in Brazil.
Major histocompatibility complex (MHC) genes have been investigated because of their crucial role in the defense against pathogens and their high degree of polymorphism. We performed a case-control study to assess a genetic association of MHC genes with susceptibility to tuberculosis (TB). The allelic lineages HLA-A*02 and B*18 were significantly less frequent in TB patients (n = 112, 44.6% women) than in controls (n = 224, 51.5% women): 18.8% vs 26.5%; odds ratio (OR) = 0.64; P = 0.037 and 2.7% vs 6.9%; OR = 0.37; P = 0.041. The negative association with haplotype HLA-B*18-MICA*018 (2.3% patients vs 6.4% controls; OR = 0.34; P = 0.035) was significant as a consequence of strong linkage disequilibrium (D' = 0.827 for patients and 0.923 for controls). These findings suggest a trend toward protection of the HLA-A*02 and HLA-B*18 alleles.
Graduate Program in Health Sciences, Center for Health Sciences, Universidade Estadual de Maringá, Maringá, PR, Brazil.
C F
CF
Souza
E N
EN
Noguti
J E L
JE
Visentainer
R F
RF
Cardoso
M L
ML
Petzl-Erler
L T
LT
Tsuneto
D000328:Adult; D000483:Alleles; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D015789:HLA-A2 Antigen / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D011110:Polymorphism, Genetic; D014376:Tuberculosis / Q000453:epidemiology / Q000235:genetics*
C524866:HLA-A*02 antigen; D015789:HLA-A2 Antigen; D015235:HLA-B Antigens; D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A