Setting a highway for converting skin into neurons.
Direct conversion of human skin fibroblasts into induced neuronal (iN) cells has been recently achieved by using different combinations of transcription factors eventually associated with microRNAs. These findings lay the ground for a straightforward and efficient generation of human neurons in vitro with elaborated functional properties instrumental for disease modeling and cell-based approaches of brain repair.
San Raffaele Scientific Institute, Via Olgettina 58, Milan 20132, Italy. broccoli.vania@hsr.it
Vania
V
Broccoli
Massimiliano
M
Caiazzo
Maria Teresa
MT
Dell'Anno
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D005347:Fibroblasts / Q000166:cytology* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D009474:Neurons / Q000166:cytology*; D012867:Skin / Q000166:cytology; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D014157:Transcription Factors