[Markers of diagnosis and treatment in 924 pregnancies with gestational diabetes mellitus].
OBJECTIVE
To evaluate the epidemiological profile and outcomes of women with gestational diabetes mellitus (GDM), determining risk factors for increased vigilance.


METHODS
We studied 924 pregnancies in 916 patients between November 6, 2001 and September 21, 2009.


RESULTS
Risk factors were found in 95.1% of cases. The prevalence of maternal diabetes, paternal diabetes and diabetes in other family members was 24.3%, 9.4% and 24.7%, respectively. Predictive factors for insulin use were: screening fasting glucose (FG) ≥ 85, Oral Glucose Tolerance Test (OGTT) FG ≥ 95, 2h glucose after 75 g ≥ 200 mg/dL, previous GDM, obesity, HbA1c > 6%, and the association of risk factors including family history of diabetes mellitus and obesity or previous GDM, the last one the most relevant (p < 0,05).


CONCLUSIONS
Risk factors were very sensitive for GDM detection, and provision of family history strengthens its relationship with T2DM. Greater vigilance is recommended for patients with predictive factors for insulin requirement.
Hospital de Clínicas, Universidade Federal do Paraná, Av. Agostinho Leão Junior 285, Curitiba, PR, Brazil.
Josiane Cristine Melchioretto
JC
Detsch
Ana Cristina Ravazzani de
AC
Almeida
Luis Gustavo Cambrussi
LG
Bortolini
Denis José
DJ
Nascimento
Fernando Cesar
FC
Oliveira Junior
Rosângela Roginski
RR
Réa
D000328:Adult; D015415:Biomarkers; D001786:Blood Glucose / Q000378:metabolism*; D016009:Chi-Square Distribution; D003920:Diabetes Mellitus / Q000453:epidemiology; D016640:Diabetes, Gestational / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D003927:Diet, Diabetic; D005192:Family Health / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D011237:Predictive Value of Tests; D011247:Pregnancy; D012307:Risk Factors
D015415:Biomarkers; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin