Interpretation of correlations between coagulation factors FV, FVIII and vWF in normal and type 2 diabetes mellitus patients.
Increased risk of vascular diseases in hypercoagulable states is assumed to be the major cause for prevalence of vascular problems in type 2 diabetes mellitus patient. The present study was undertaken to explore the basis underlying the correlation between the aforesaid three coagulation factors with reference to the relevant mechanistic findings using statistical calculation. Our findings showed that the correlation between each pairs of coagulation factors, FV, FVIII and vWF could be easily interpreted using previously characterized interactions between these factors. Also, given the sequence similarities between FV and FVIII as well as the results of this study, it was indicated, for the first time, that FV may bind to vWF in the same way as FVIII binds. This finding seems to be of great importance to be evaluated through experimental techniques.
Department of Biology, Faculty of Science, Shahid Chamran University, Ahwaz, Iran.
Mohammad Reza
MR
Dayer
Maysam
M
Mard-Soltani
Mohammad Saaid
MS
Dayer
Sayed Mohammad Reza
SM
Alavi
D016022:Case-Control Studies; D003164:Competitive Bidding; D003627:Data Interpretation, Statistical; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000235:genetics; D003925:Diabetic Angiopathies / Q000097:blood / Q000235:genetics; D005165:Factor V / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D005169:Factor VIII / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014841:von Willebrand Factor / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*
D014841:von Willebrand Factor; D005165:Factor V; D005169:Factor VIII