Age-related neointimal hyperplasia is associated with monocyte infiltration after balloon angioplasty.
Carotid angioplasty is associated with adverse events in elderly patients; it is unclear whether this is related to an altered inflammatory axis. The carotid arteries of young (6 months) or aged (22-24 months) Fischer 344 rats were balloon injured. Aged rats had reduced lumen area (0.18 ± 0.03 vs 0.24 ± 0.01 mm(2), p = .02) and increased neointimal thickening (0.15 ± 0.04 vs 0.08 ± 0.03 mm(2), p = .006). Aged rats had increased circulating monocytes (96 ± 21 vs. 54 ± 7; p = .002) as well as increased numbers of monocytes at the post-angioplasty site. Aged rats had sustained monocyte chemotactic protein-1 expression after angioplasty but young rats did not. Aged arteries also exhibited defective vasorelaxation and abnormal eNOS localization. Aged (≥80 years) human patients with high-grade carotid stenosis had increased number of monocytes (9.1% ± 0.4%) compared with younger (65-80 years) patients (8.1% ± 0.3%, p = .013). Aged rats develop neointimal hyperplasia after carotid angioplasty with increased numbers of monocytes, and elderly humans with carotid stenosis have increased numbers of circulating monocytes. These preliminary results may suggest a role for monocytes in the response to carotid angioplasty.
The Stanley J. Dudrick Department of Surgery, Saint Mary’s Hospital, Waterbury, Connecticut, USA.
Sammy D D
SD
Eghbalieh
Paraag
P
Chowdhary
Akihito
A
Muto
Kenneth R
KR
Ziegler
Fabio A
FA
Kudo
Jose M
JM
Pimiento
Issa
I
Mirmehdi
Lynn S
LS
Model
Yuka
Y
Kondo
Toshiya
T
Nishibe
Alan
A
Dardik
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism / Q000473:pathology*; D000800:Angioplasty, Balloon / Q000009:adverse effects*; D000818:Animals; D002339:Carotid Arteries / Q000473:pathology*; D020212:Carotid Artery Injuries / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D018932:Chemokine CCL2 / Q000096:biosynthesis* / Q000235:genetics; D004195:Disease Models, Animal; D004587:Electrophoresis, Agar Gel; D005786:Gene Expression Regulation; D006801:Humans; D006965:Hyperplasia; D009000:Monocytes / Q000378:metabolism / Q000473:pathology*; D058426:Neointima / Q000378:metabolism / Q000473:pathology*; D012313:RNA / Q000235:genetics; D051381:Rats; D011916:Rats, Inbred F344; D020133:Reverse Transcriptase Polymerase Chain Reaction
C111835:CCL2 protein, human; D018932:Chemokine CCL2; D012313:RNA