Delayed match-to-sample performance in African green monkeys (Chlorocebus aethiops sabaeus):  effects of benzodiazepine, cholinergic, and anticholinergic drugs.
Delayed match-to-sample (DMTS) procedures are among the most commonly used attention and memory tasks in behavioral pharmacology and have been utilized in a variety of species. Although macaque species such as the rhesus and cynomolgus macaque are often used for such studies, availability and disease transmission raise concerns over their use. The present study investigated whether the African green monkey might function as a suitable alternative by evaluating operant performance on a DMTS task and comparing this species' response to some commonly used drugs (0.025-0.075 mg/kg physostigmine, 0.0033-0.03 mg/kg scopolamine, 0.014-0.44 mg/kg atropine, 0.125-1.0 mg/kg midazolam, and 0.125-2.0 mg/kg diazepam) to the responses previously reported in macaques. Results demonstrated that African green monkeys are capable of learning and performing a DMTS task, and dose-effect functions for behavioral pharmacology were quite similar to those reported for rhesus macaques and other nonhuman primate species. Thus, the African green monkey may function as a suitable alternative to macaque species in behavioral pharmacology research.
Neurobehavioral Toxicology Branch, Analytical Toxicology Division, US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland 21010, USA. Todd.Myers2@us.army.mil
Todd M
TM
Myers
Lindsey R
LR
Hamilton
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001288:Attention / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects*; D002522:Chlorocebus aethiops / Q000523:psychology*; D018680:Cholinergic Antagonists / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology; D018757:GABA Modulators / Q000494:pharmacology*; D007858:Learning / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects*; D008874:Midazolam / Q000494:pharmacology; D009483:Neuropsychological Tests; D010830:Physostigmine / Q000494:pharmacology; D012601:Scopolamine / Q000494:pharmacology
D018680:Cholinergic Antagonists; D002800:Cholinesterase Inhibitors; D018757:GABA Modulators; D001285:Atropine; D010830:Physostigmine; D012601:Scopolamine; D003975:Diazepam; D008874:Midazolam