Bioderived polyelectrolyte nanogels for robust antigen loading and vaccine adjuvant effects.
An easy but robust strategy for the synthesis of bioderived polyelectrolyte nanogels for protein antigen loading and vaccine adjuvant systems that can improve both humoral (Th2) and cellular immunity (Th1) is presented. The synthesized polyelectrolyte nanogels promote the uptake of antigens into antigen-presenting cells and strongly induce ovalbumin-specific INF-γ producing cells, cytotoxic T cell activity, and antibody production.
Graduate School and Department of Analytical Science and Technology, Chungnam National University, Daejeon 305-764, South Korea.
Yong Taik
YT
Lim
Sang-Mu
SM
Shim
Young-Woock
YW
Noh
Kyung-Soon
KS
Lee
Doo-Yeol
DY
Choi
Hiroshi
H
Uyama
Hee Ho
HH
Bae
Ji Hyun
JH
Kim
Kwan Soo
KS
Hong
Moon-Hee
MH
Sung
Haryoung
H
Poo
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D017951:Antigen Presentation / Q000187:drug effects*; D000941:Antigens / Q000276:immunology*; D001672:Biocompatible Materials / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects; D003713:Dendritic Cells / Q000166:cytology / Q000187:drug effects; D004573:Electrolytes / Q000494:pharmacology*; D007111:Immunity, Cellular / Q000187:drug effects; D056724:Immunity, Humoral / Q000187:drug effects; D051379:Mice; D008855:Microscopy, Electron, Scanning; D008856:Microscopy, Fluorescence; D000080385:Nanogels; D010047:Ovalbumin / Q000276:immunology; D010316:Particle Size; D011092:Polyethylene Glycols / Q000494:pharmacology*; D011094:Polyethyleneimine / Q000494:pharmacology*; D055672:Static Electricity; D014612:Vaccines / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000941:Antigens; D001672:Biocompatible Materials; D004573:Electrolytes; D000080385:Nanogels; D014612:Vaccines; C413692:polyethylene glycol polyethyleneimine nanogel; D011092:Polyethylene Glycols; D011094:Polyethyleneimine; D010047:Ovalbumin