Synthesis of rare earth catalysts and their applications for enantioselective synthesis of heterocyclic β-amino alcohols.
A new family of chiral lanthanide complexes derived from (R)-binaphthol has been synthesized by a one-pot procedure using only commercially available substrates. These complexes were evaluated for the aminolysis of meso-epoxides and proved to be efficient enantioselective catalysts. The samarium complex coordinated by two (R)-binaphthoxide ligands was the most enantioselective catalyst of this series. β-Amino alcohols including heterocycles have been isolated with enantiomeric excesses up to 84%.
Equipe de Catalyse Moléculaire, ICMMO, UMR 8182, Bâtiment 420, Université Paris-Sud, 91405 Orsay, France.
Myriam
M
Martin
Ahmad
A
El Hellani
Jing
J
Yang
Jacqueline
J
Collin
Sophie
S
Bezzenine-Lafollée
D000605:Amino Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008674:Metals, Rare Earth / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*
D000605:Amino Alcohols; D006571:Heterocyclic Compounds; D008674:Metals, Rare Earth; D009942:Organometallic Compounds