Excessive daytime sleepiness and sleep-disordered breathing disturbances in survivors of childhood central nervous system tumors.
BACKGROUND
Improvements in treatment and management for pediatric central nervous system (CNS) tumors have increased survival rates, allowing clinicians to focus on long-term sequelae, including sleep disorders. The objective of this study was to describe a series of CNS tumor survivors who had sleep evaluations that included polysomnography (PSG) with attention to sleep disorder in relation to the tumor site.


METHODS
We report on 31 patients who had retrievable reports including an overnight PSG; 17 also underwent multiple sleep latency tests (MSLT) to characterize their sleepiness.


RESULTS
Mean age at tumor diagnosis was 7.4 years, mean age at sleep referral 14.3 years, and a mean time between tumor diagnosis and sleep referral of 6.9 years. The most common tumor location was the suprasellar region, the most common reason for sleep referral was excessive daytime sleepiness (EDS), and the most common sleep diagnosis was obstructive sleep apnea (n = 14) followed by central sleep apnea (n = 4), hypersomnia due to medical condition (n = 4), and narcolepsy (n = 3). Twenty-six of the 31 subjects were obese/overweight, and among those with the concurrent complaint of EDS, the mean sleep latency on MSLT was 3.16 minutes, consistent with excessive sleepiness.


CONCLUSIONS
Suprasellar region tumor survivors who are obese or overweight are more likely to have complaints of EDS and are at greater risk of sleep-disordered breathing. Sleep-related symptoms may not be recognized and referral initiated until years after CNS diagnosis. A periodic and thorough sleep history should be taken when caring for CNS tumor survivors.
Division of Nursing Research, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. belinda.mandrell@stjude.org
Belinda N
BN
Mandrell
Merrill
M
Wise
Robert A
RA
Schoumacher
Michele
M
Pritchard
Nancy
N
West
Kirsten K
KK
Ness
Valerie McLaughlin
VM
Crabtree
Thomas E
TE
Merchant
Brannon
B
Morris
D000293:Adolescent; D000328:Adult; D016543:Central Nervous System Neoplasms / Q000150:complications* / Q000401:mortality; D002648:Child; D002675:Child, Preschool; D006970:Disorders of Excessive Somnolence / Q000209:etiology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D012891:Sleep Apnea Syndromes / Q000209:etiology*; D017741:Survivors