Molecular functions of syndecan-1 in disease.
Syndecan-1 is a cell surface heparan sulfate proteoglycan that binds to many mediators of disease pathogenesis. Through these molecular interactions, syndecan-1 can modulate leukocyte recruitment, cancer cell proliferation and invasion, angiogenesis, microbial attachment and entry, host defense mechanisms, and matrix remodeling. The significance of syndecan-1 interactions in disease is underscored by the striking pathological phenotypes seen in the syndecan-1 null mice when they are challenged with disease-instigating agents or conditions. This review discusses the key molecular functions of syndecan-1 in modulating the onset, progression, and resolution of inflammatory diseases, cancer, and infection.
Department of Medicine, Children's Hospital, Harvard Medical School, Boston, MA 02115, United States.
Yvonne Hui-Fang
YH
Teng
Rafael S
RS
Aquino
Pyong Woo
PW
Park
D000818:Animals; D007239:Infections / Q000378:metabolism* / Q000473:pathology; D007249:Inflammation / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D018345:Mice, Knockout; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D053668:Syndecan-1 / Q000235:genetics* / Q000378:metabolism*
D053668:Syndecan-1