Phenol esters and other constituents from the stem barks of Stereospermum acuminatissimum.
A new ester, 2-(4'-hydroxyphenyl)ethyl dotriacontanoate (1), and a new inseparable mixture of octacosan-1,28-dioldiferulate and triacontan-1,30-dioldiferulate (2) were isolated from the stem barks of Stereospermum acuminatissimum, along with 24 known compounds including 4 triterpenoids, 11 anthraquinones, 2 lignans, 3 phenylpropanoids, 2 4-hydroxyphenethyl esters, 1 methoxyphenol, and 1 iridoid. The structures of the new metabolites were determined with the help of spectroscopic data including extensive 2D NMR spectroscopy. The known compounds were identified by comparison of their physical and spectroscopic data with those reported in the literature. The compounds were tested against Candida albicans ATCC 24433, C. albicans ATCC 90028, Candida glabrata ATCC 90030, Candida krusei ATCC 6258, and Candida parapsilosis ATCC 22019. Some of them were moderately active.
Department of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon.
Sylvain Valère Tanemossu
SV
Sob
Hippolyte Kamdem
HK
Wabo
Chun-Ping
CP
Tang
Pierre
P
Tane
Bonaventure Tchaleu
BT
Ngadjui
Yang
Y
Ye
D000880:Anthraquinones / Q000737:chemistry; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029402:Bignoniaceae / Q000737:chemistry*; D002163:Cameroon; D002176:Candida albicans / Q000187:drug effects; D041221:Candida glabrata / Q000187:drug effects; D004952:Esters; D005227:Fatty Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010666:Phenylpropionates / Q000737:chemistry / Q000302:isolation & purification*; D024301:Plant Bark / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*
C569577:2-(4'-hydroxyphenyl)ethyl dotriacontanoate; D000880:Anthraquinones; D000935:Antifungal Agents; D004952:Esters; D005227:Fatty Acids; D039823:Iridoids; D017705:Lignans; D010636:Phenols; D010666:Phenylpropionates; D014315:Triterpenes