DTI reveals network injury in perinatal stroke.
BACKGROUND
Previous research showed acute diffusion-weighted imaging changes in pulvinar after extensive cortical injury from neonatal stroke. The authors used diffusion tensor imaging (DTI) to see how separate regions of ipsilateral thalamus are directly affected after a primary hit to their connected cortex in neonatal stroke.


METHODS
The authors analysed DTI images of three term infants with acute unilateral cortical arterial ischaemic stroke. Probabilistic tractography was used to define separate thalamic regions of interests (ROIs). The authors evaluated the three eigenvalues (EV) and apparent diffusion coefficient (ADC) values in the ROIs.


RESULTS
The ADC and EV in voxels of ROIs placed within the nuclei corresponding to ischaemic cortex were significantly lower than those in the unaffected contralesional thalamic nuclei.


CONCLUSIONS
Our findings support the concept of acute network injury in neonatal stroke. ADC and EV were altered in specific thalamic regions that corresponded to the specific cortical areas affected by the primary ischaemic injury.
Department of Neonatology, Sophia Children's Hospital, Dr Molenwaterplein 60, Rotterdam 3015GJ, The Netherlands. j.dudink@erasmusmc.nl
Jeroen
J
Dudink
Serena J
SJ
Counsell
Maarten H
MH
Lequin
Paul P
PP
Govaert
D002545:Brain Ischemia / Q000473:pathology*; D056324:Diffusion Tensor Imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007231:Infant, Newborn; D020244:Infarction, Middle Cerebral Artery / Q000473:pathology*; D020762:Infarction, Posterior Cerebral Artery / Q000473:pathology*; D020649:Pulvinar / Q000473:pathology; D013788:Thalamus / Q000473:pathology*