The association between plasma uric acid and renal function decline in a Chinese population-based cohort.
BACKGROUND
Uric acid may be associated with kidney damage through multiple pathways. Previous cohort studies revealed inconsistent results, and research among the non-hypertensive and non-diabetic population are extremely limited.


METHODS
This prospective cohort study included 1410 residents aged 59.1 ± 9.4 years from an urban district of Beijing, China. All participants had an estimated glomerular filtration rate >60 mL/min/1.73m(2). Plasma uric acid was assessed at baseline; and its relation with renal function decline after 4 years' follow-up was analyzed.


RESULTS
During 4 years (5630 person-years) of follow-up, 168 patients (11.9%) developed renal function decline. After adjusting for potential confounders including baseline renal function, plasma uric acid levels were independently associated with an increased risk of renal function decline, with a fully adjusted odds ratio (OR) of 1.19 [per 1 mg/dL increase; 95% confidence interval (CI) 1.04-1.38]. Analysis among 615 hypertension-free and diabetes-free participants yielded similar results, with an adjusted OR of 1.50 (per 1 mg/dL increase; 95% CI 1.13-1.98).


CONCLUSIONS
Our prospective cohort study revealed that plasma uric acid level is independently associated with an increasing likelihood of renal function decline.
Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China.
Luxia
L
Zhang
Fang
F
Wang
Xingyu
X
Wang
Lisheng
L
Liu
Haiyan
H
Wang
D000368:Aged; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D002681:China; D002908:Chronic Disease; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007674:Kidney Diseases / Q000097:blood / Q000453:epidemiology* / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
D015415:Biomarkers; D014527:Uric Acid