Once upon a cataract surgeon.
A 60-year-old man presented with diplopia and neurocognitive deficits, which progressed rapidly over several months. Magnetic resonance imaging of the head revealed bilateral signal abnormalities and diffusion-weighted imaging restriction in bilateral basal ganglia, thalami, mesial temporal regions, and periaqueductal gray matter. Cerebrospinal fluid analysis was positive for 14-3-3 and tau proteins. The patient developed progressive neurocognitive decline followed by sleep disturbance and myoclonic jerking consistent with probable Creutzfeldt-Jakob disease.
The Methodist Hospital, Houston, Texas 77030, USA.
Roma P
RP
Patel
John
J
Volpi
Andrew G
AG
Lee
Jason J S
JJ
Barton
D048948:14-3-3 Proteins / Q000134:cerebrospinal fluid; D001479:Basal Ganglia / Q000473:pathology; D003072:Cognition Disorders / Q000175:diagnosis; D007562:Creutzfeldt-Jakob Syndrome / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D004172:Diplopia / Q000175:diagnosis; D004569:Electroencephalography; D017809:Fatal Outcome; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010487:Periaqueductal Gray / Q000473:pathology; D013788:Thalamus / Q000473:pathology; D016875:tau Proteins / Q000134:cerebrospinal fluid
D048948:14-3-3 Proteins; D016875:tau Proteins