The extent of cutaneous lesions predicts outcome in extranodal nasal-type natural killer/T-cell lymphoma of the upper aerodigestive tract with secondary cutaneous involvement.
This study determined the clinical characteristics and prognosis for patients with extranodal nasal-type natural killer/T-cell lymphoma (NKTCL) with secondary cutaneous involvement. Twenty-eight patients with NKTCL of the upper aerodigestive tract with secondary cutaneous involvement were reviewed. The median overall survival (OS) was 21.5 months from the first diagnosis, and 12.3 months from the presentation of a cutaneous lesion. The 5-year OS rate was 43.1% (median, 28 months) for patients with localized cutaneous disease compared with 0% (median, 3.6 months) for generalized cutaneous disease (p = 0.017). The 2-year OS rates were 67.5% for patients who achieved a complete response (CR) compared with 19.4% (median, 5.2 months) for patients who did not (p = 0.003). Patients with NKTCL with secondary cutaneous dissemination overall have a poor prognosis, but a relatively favorable prognosis was identified for the small subgroup of patients who had localized cutaneous lesions and achieved a CR.
Department of Radiation Oncology, Chinese Academy of Medical Sciences, Beijing , People's Republic of China.
Shu-Nan
SN
Qi
Ye-Xiong
YX
Li
Wei-Hu
WH
Wang
Jing
J
Jin
Shu-Lian
SL
Wang
Yue-Ping
YP
Liu
Yong-Wen
YW
Song
Hui
H
Fang
Hua
H
Ren
Ning-Ning
NN
Lu
Qing-Feng
QF
Liu
Run-Ye
RY
Wu
Xi-Mei
XM
Zhang
Xin-Fan
XF
Liu
Zi-Hao
ZH
Yu
D000368:Aged; D004067:Digestive System Neoplasms; D006801:Humans; D054391:Lymphoma, Extranodal NK-T-Cell / Q000175:diagnosis* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000175:diagnosis* / Q000401:mortality; D011237:Predictive Value of Tests; D011379:Prognosis; D012142:Respiratory Tract Neoplasms; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000473:pathology*; D016019:Survival Analysis; D015996:Survival Rate