New solid lipid microparticles for controlled ibuprofen release: formulation and characterization study.
A hot melt dispersion method was used to prepare new sustained release ibuprofen composite microparticles of a solid lipid at ambient temperature, cetyl alcohol. The dispersion of colloidal silicon dioxide nanoparticles (hydrophilic Aerosil 200 or hydrophobic Aerosil R974) either in the oily phase or in the aqueous phase led to the preparation of large (about 400 μm diameter) surfactant free free-flowing particles. Mapping-scanning electronic microscopy using silicon probe revealed that silicon was in the oily core in all cases. The nature of silica nanoparticles and the way used for their dispersion influenced the internal structure of the composite microparticles and the aggregation of nanoparticles in the core of the microparticles. Hydrophobic Aerosil R974 allowed the formation of homogeneous microparticles. Although silica nanoparticles had no influence on thermic profile, crystalline state of ibuprofen and lipid, they had an influence on the kinetics drug release related to the increase of the size of the composite solid lipid microparticles prepared.
Institut Charles Gerhardt Montpellier UMR 5253 CNRS-UM2-ENSCM-UM1, Matériaux Avancés pour Catalyse et Santé, ENSCM, 8 rue de l'Ecole Normale, 34296 Montpellier Cedex 5, France.
Laurent
L
Perge
Mike
M
Robitzer
Coralie
C
Guillemot
Jean-Marie
JM
Devoisselle
Françoise
F
Quignard
Philippe
P
Legrand
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004339:Drug Compounding; D005233:Fatty Alcohols / Q000737:chemistry*; D007052:Ibuprofen / Q000737:chemistry*; D007700:Kinetics; D008027:Light; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles; D010316:Particle Size; D012542:Scattering, Radiation; D012822:Silicon Dioxide / Q000737:chemistry; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013678:Technology, Pharmaceutical / Q000379:methods; D014961:X-Ray Diffraction
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005233:Fatty Alcohols; D012822:Silicon Dioxide; C005031:cetyl alcohol; D007052:Ibuprofen