Gold-catalyzed oxidative acyloxylation of arenes.
A variety of nonactivated hindered aromatic rings are acyloxylated (22 examples, up to 83% yield) in the presence of PPh(3)AuCl as the catalyst and di(acetoxy)iodobenzene as the oxidant. The reaction proceeds at 110 °C in an acid media and allows the formation of both hindered acetoxy and acyloxy derivatives. This methodology nicely complements the Pd-catalyzed arene acyloxylation reaction, which is not operating on hindered substrates and allows the Au-catalyzed unprecedented acyloxylation reaction of arenes, implying various carboxylic acids.
Chimie ParisTech, Laboratoire Charles Friedel, UMR 7223 11 rue P. et M. Curie, 75231 Paris Cedex 05, France.
Alexandre
A
Pradal
Patrick Y
PY
Toullec
Véronique
V
Michelet