Polymers interfacing with biology.
The development of various controlled radical polymerization techniques as well as site- and residue specific strategies to modify peptides/proteins with synthetic polymers have made polymer chemistry a powerful tool to address materials problems at the biology interface. This article will present recent examples for bioactive surface modification and polymer therapeutics; it will highlight the use of controlled radical polymerization techniques and bioconjugation strategies to develop surface coatings for regenerative medicine and diagnostics, respectively, polymer-based nanomedicines.
Ecole Polytechnique Fédérale de Lausanne (EPFL), Institut des Matériaux and Institut des Sciences et Ingénierie Chimiques, Laboratoire des Polymères, Bâtiment MXD, Station 12, CH-1015 Lausanne.
Frederik
F
Wurm
Harm-Anton
HA
Klok
D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D050997:Nanomedicine; D010455:Peptides / Q000008:administration & dosage / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry; D011506:Proteins / Q000008:administration & dosage / Q000737:chemistry*; D044968:Regenerative Medicine; D013499:Surface Properties
D004337:Drug Carriers; D010455:Peptides; D004364:Pharmaceutical Preparations; D011108:Polymers; D011506:Proteins