Risk of glycemic disorder in elderly women adjusted by anthropometric parameters and cytokine genotypes.
OBJECTIVE
The objective of the present study was to examine the association of glucose intolerance and type-2 diabetes mellitus with the -174 G > C and -308 G > A allelic variations of IL-6 and TNF-α, respectively, through anthropometric measurements and age strata.


METHODS
This is a cross-sectional study using data from 285 community dwelling elderly women who underwent physical, biochemical, and genetic examinations.


RESULTS
Genotype-unadjusted analysis revealed that the risk of glucose intolerance and diabetes in elderly women with elevated BMI was 1.71 and 2.82 times higher, respectively, whereas age and conicity index did not show predictive value. Prevalence ratios for glucose intolerance and diabetes across allelic variants of IL-6 and TNF-α did not associate IL-6 with unbalanced glucose levels, despite adjustment for BMI, age, and conicity index. Conversely, carriers of the TNF-α A allele were 2.06 and 5.58 times more likely to exhibit glucose intolerance and diabetes, respectively, compared to GG homozygotes.


CONCLUSIONS
Our results suggest that bearing the A allele of the -308 G > A polymorphism of TNF-α predisposes to anthropometric measure-sensitive impaired glucose metabolism in older women.
Núcleo Interdisciplinar de Pesquisa, ICESP/Faculdades Promove de Brasília, DF, Brazil.
Aparecido Pimentel
AP
Ferreira
Cristiane Batisti
CB
Ferreira
Vinícius Carolino
VC
Souza
Audrey Cecília Tonet
AC
Furioso
Juliana Oliveira
JO
Toledo
Clayton Franco
CF
Moraes
Cláudio
C
Córdova
Otávio Tolêdo
OT
Nóbrega
D000368:Aged; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D005838:Genotype; D018149:Glucose Intolerance / Q000235:genetics*; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha