A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1.
Gastric cancer, including the cardia and non-cardia types, is the second leading cause of cancer-related deaths worldwide. To identify genetic risk variants for non-cardia gastric cancer, we performed a genome-wide association study in 3,279 individuals (1,006 with non-cardia gastric cancer and 2,273 controls) of Chinese descent. We replicated significant associations in an additional 6,897 subjects (3,288 with non-cardia gastric cancer and 3,609 controls). We identified two new susceptibility loci for non-cardia gastric cancer at 5p13.1 (rs13361707 in the region including PTGER4 and PRKAA1; odds ratio (OR) = 1.41; P = 7.6 × 10(-29)) and 3q13.31 (rs9841504 in ZBTB20; OR = 0.76; P = 1.7 × 10(-9)). Imputation analyses also confirmed previously reported associations of rs2294008 and rs2976392 on 8q24, rs4072037 on 1q22 and rs13042395 on 20p13 with non-cardia gastric cancer susceptibility in the Han Chinese population.
Bio-X Institutes, Ministry of Education Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, China. shiyongyong@gmail.com
Yongyong
Y
Shi
Zhibin
Z
Hu
Chen
C
Wu
Juncheng
J
Dai
Huizhang
H
Li
Jing
J
Dong
Meilin
M
Wang
Xiaoping
X
Miao
Yifeng
Y
Zhou
Feng
F
Lu
Hanze
H
Zhang
Lingmin
L
Hu
Yue
Y
Jiang
Zhiqiang
Z
Li
Minjie
M
Chu
Hongxia
H
Ma
Jiaping
J
Chen
Guangfu
G
Jin
Wen
W
Tan
Tangchun
T
Wu
Zhengdong
Z
Zhang
Dongxin
D
Lin
Hongbing
H
Shen
D055372:AMP-Activated Protein Kinases / Q000235:genetics*; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D005260:Female; D056426:Genetic Loci; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D058309:Receptors, Prostaglandin E, EP4 Subtype / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics
D009419:Nerve Tissue Proteins; C545650:PTGER4 protein, human; D058309:Receptors, Prostaglandin E, EP4 Subtype; D014157:Transcription Factors; C427486:ZBTB20 protein, human; D055372:AMP-Activated Protein Kinases; C526180:PRKAA1 protein, human