Blood pressure regulation and resting heart rate abnormalities in adolescent girls with polycystic ovary syndrome.
OBJECTIVE
To assess the risk of cardiovascular disease on the basis of biochemical, echocardiographic, and 24-hour blood pressure (BP) monitoring parameters in adolescent girls with polycystic ovary syndrome (PCOS).


METHODS
Cross-sectional study.


METHODS
Academic and research institution.


METHODS
Thirty-four obese and nonobese girls with PCOS were evaluated and compared with body mass index-matched girls with regular menses.


METHODS
None.


METHODS
Androgens, gonadotropins, lipids, and fasting and oral glucose tolerance test-stimulated glucose and insulin concentrations were measured. Echocardiographic assessment and 24-hour BP monitoring were done.


RESULTS
Compared with obese controls, obese girls with PCOS had significantly higher 24-hour mean BP, day mean BP, day diastolic BP, and diastolic BP nighttime dip (75.5 ± 4.5 mm Hg vs. 71.7 ± 3.7 mm Hg; 78.2 ± 5.0 mm Hg vs. 73.6 ± 4.0 mm Hg; 67.6 ± 4.9 mm Hg vs. 63.7 ± 3.7 mm Hg; and 20.2% ± 5.2% vs. 15.0% ± 6.6%, respectively). Obese girls with PCOS had significantly higher night heart rate than obese controls (60.4 ± 5.6 beats per minute vs. 61.7 ± 4.8 beats per minute). Left ventricle end-diastolic (4.6 ± 0.3 cm vs. 4.2 ± 0.2 cm) and end-systolic diameter (3.0 ± 0.3 cm vs. 2.7 ± 0.2 cm) were also significantly higher in nonobese girls with PCOS than in nonobese controls; however, all values were still within the accepted range of normal limits.


CONCLUSIONS
Higher night heart rate in obese girls with PCOS and higher day BP but preserved diastolic nocturnal dip in nonobese girls with PCOS may be regarded as early cardiovascular disease risk factors.
Department of Pediatrics, Medical University of Silesia, Katowice, Poland. azachurzok@sum.edu.pl
Agnieszka
A
Zachurzok-Buczynska
Leslaw
L
Szydlowski
Aneta
A
Gawlik
Krzysztof
K
Wilk
Ewa
E
Malecka-Tendera
D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000502:physiology*; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D005951:Glucose Tolerance Test; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000097:blood; D008991:Monitoring, Physiologic; D009765:Obesity / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology*; D012146:Rest / Q000502:physiology*; D012307:Risk Factors
D001786:Blood Glucose; D007328:Insulin