Interleukin-6 plasmatic levels in patients with head trauma and intracerebral hemorrhage.
The exact role of inflammatory response in hemorrhagic contusions is not fully characterized. The present study quantified IL-6 plasmatic levels in patients with closed head trauma and hemorrhagic contusions during the first 6 to 12 hours postrauma. The association between the plasmatic IL-6 levels, severity of trauma according to the Glasgow Coma Scale, volume of intracerebral hemorrhage and patient's clinical evolution were investigated. Although inflammation is a multifactorial process, a strong correlation between IL-6 levels, volume of traumatic hemorrhage and in-hospital evolution could be observed. A correlation between the IL-6 levels quantified 6 hours postrauma and progression of lesion volume between admission and 12 hours postrauma is suggested. The present study reinforces the importance of IL-6 in influencing the clinical conditions of a patient with cerebral injuries, particularly hemorrhagic contusions.
Center for Health and Biological Sciences, Pontificia Universidade Católica do Paraná (PUCPR).
Alessandra Armstrong
AA
Antunes
Vanessa Santos
VS
Sotomaior
Keyth Suga
KS
Sakamoto
Cyro Pereira
CP
de Camargo Neto
Carolina
C
Martins
Luiz Roberto
LR
Aguiar