[Endothelial origin for hematopoietic stem cells: a visual proof].
Hematopoietic stem cells (HSC) are the source of all blood cell types produced during the entire life of an organism. They appear during embryonic development, where they will transit through different successive hematopoietic organs, before to finally colonize the bone marrow. Nowadays, the precise origin of HSC remains a matter of controversy. Different HSC precursor candidates, located in different anatomical sites, have been proposed. Here, we summarize and discuss the different theories in light of the recent articles, especially those using in vivo confocal microscopy technology.
Erasmus Stem Cell Institute, Department of Cell Biology, Erasmus Medical Center, Rotterdam, Pays-Bas.
Jean-Charles
JC
Boisset
Catherine
C
Robin
D000818:Animals; D001011:Aorta / Q000166:cytology / Q000196:embryology; D001717:Birds / Q000196:embryology; D016026:Bone Marrow Transplantation; D019070:Cell Lineage; D004625:Embryo, Nonmammalian / Q000166:cytology; D042783:Endothelial Cells / Q000166:cytology*; D004730:Endothelium, Vascular / Q000166:cytology / Q000196:embryology; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006413:Hematopoietic System / Q000196:embryology; D006801:Humans; D008322:Mammals / Q000196:embryology; D008648:Mesoderm / Q000166:cytology; D051379:Mice; D018613:Microscopy, Confocal / Q000379:methods*; D011828:Radiation Chimera; D013045:Species Specificity; D015027:Zebrafish / Q000196:embryology