Translational studies on PYY as a novel target in obesity.
The obesity epidemic has a direct impact on every aspect of health. Current strategies to treat obesity are limited and there is a need to pioneer novel solutions. Anorectic gut hormones, physiologically secreted post-prandially to mediate satiety, have recently emerged as potential therapeutic targets in obesity. Peptide tyrosine tyrosine (PYY) is one such anorectic gut hormone, secreted from entero-endocrine L cells, which acts on neuropeptide Y (NPY) receptors within the central appetite circuit. Since the first intravenous administration of PYY to man nearly a decade ago, a number of translational studies and clinical trials have ensued with a view to developing this peptide as a treatment for obesity. This review reports on the current state of play of this on-going research.
Department of Diabetes, Endocrinology and Metabolism, Hammersmith Campus, Imperial College London, Du Cane Road, London W12 0NN, United Kingdom.
Sagen
S
Zac-Varghese
Akila
A
De Silva
Stephen R
SR
Bloom
D000818:Animals; D019440:Anti-Obesity Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001067:Appetite Depressants / Q000494:pharmacology / Q000627:therapeutic use; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D058990:Molecular Targeted Therapy; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism; D019894:Peptide YY / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D011964:Receptors, Gastrointestinal Hormone / Q000819:agonists / Q000378:metabolism; D017476:Receptors, Neuropeptide Y / Q000037:antagonists & inhibitors / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D057170:Translational Research, Biomedical
D019440:Anti-Obesity Agents; D001067:Appetite Depressants; D005765:Gastrointestinal Agents; D011964:Receptors, Gastrointestinal Hormone; D017476:Receptors, Neuropeptide Y; C100568:neuropeptide Y5 receptor; C082172:peptide YY receptor; D019894:Peptide YY