No significant association between Catechol-O-methyl transferase (COMT) -287A/G gene polymorphism and Tourette's syndrome in family-based association study in Chinese Han population.
To identify the association of Catechol-O-methyl transferase (COMT) -287A/G polymorphism with susceptibility to TS in Chinese Han population. We evaluated the genetic contribution of the COMT -287A/G polymorphism in 108 TS patients including all their parents in Chinese Han population using transmission disequilibrium test and haplotype relative risk design. Our results revealed that no significant association was found in COMT -287A/G genotypic and allelic frequencies with TS. Our results also suggested that there may be a lack of association between the TS and -287A/G polymorphism of COMT in Chinese Han population.
Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Medical College, Qingdao University, China.
Shiguo
S
Liu
Mingji
M
Yi
Fengguang
F
Qi
Yuping
Y
Sun
Fengyuan
F
Che
Xu
X
Ma
D000293:Adolescent; D002394:Catechol O-Methyltransferase / Q000097:blood / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D002681:China; D005190:Family; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D008297:Male; D015588:Observer Variation; D011110:Polymorphism, Genetic / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D005879:Tourette Syndrome / Q000097:blood / Q000235:genetics*
D002394:Catechol O-Methyltransferase