Cerebellum shapes hippocampal spatial code.
Spatial representation is an active process that requires complex multimodal integration from a large interacting network of cortical and subcortical structures. We sought to determine the role of cerebellar protein kinase C (PKC)-dependent plasticity in spatial navigation by recording the activity of hippocampal place cells in transgenic L7PKCI mice with selective disruption of PKC-dependent plasticity at parallel fiber-Purkinje cell synapses. Place cell properties were exclusively impaired when L7PKCI mice had to rely on self-motion cues. The behavioral consequence of such a deficit is evidenced here by selectively impaired navigation capabilities during a path integration task. Together, these results suggest that cerebellar PKC-dependent mechanisms are involved in processing self-motion signals essential to the shaping of hippocampal spatial representation.
Neurobiologie des Processus Adaptatifs (UMR 7102), Navigation, Memory, and Aging (ENMVI) Team, Université Pierre et Marie Curie-Centre National de la Recherche Scientifique (CNRS), F-75005 Paris, France.
Christelle
C
Rochefort
Arnaud
A
Arabo
Marion
M
André
Bruno
B
Poucet
Etienne
E
Save
Laure
L
Rondi-Reig
D000818:Animals; D056547:CA1 Region, Hippocampal / Q000166:cytology / Q000502:physiology*; D002531:Cerebellum / Q000201:enzymology / Q000502:physiology*; D003463:Cues; D003624:Darkness; D036881:Long-Term Synaptic Depression; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009043:Motor Activity; D009949:Orientation; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000378:metabolism; D011689:Purkinje Cells / Q000502:physiology; D017966:Pyramidal Cells / Q000502:physiology*; D013028:Space Perception
D011493:Protein Kinase C