Fenofibrate-induced rhabdomyolysis in a patient with chronic renal failure due to nephrotic syndrome: a rare case report.
OBJECTIVE
Fenofibrate is a fibric acid derivative that is used alone or combination with statins in the treatment of hyperlipidemia. These drugs have potential risks, including rhabdomyolysis and acute renal failure. Despite reports of rhabdomyolysis with the use of fenofibrate alone or with statin-fibrate combinations, there have been no cases of rhabdomyolysis described when fenofibrate was used alone to treat patients with chronic renal failure owing to nephrotic syndrome.


METHODS
We report on a 26-year-old male who presented with fenofibrate-induced rhabdomyolysis with chronic renal failure due to nephrotic syndrome.


RESULTS
After the discontinuation of fenofibrate, the patient was treated with intravenous fluid replacement and urine alkalization. Subsequently, his clinical and biochemical findings improved.


CONCLUSIONS
Before starting fenofibrate therapy, the causes of secondary hyperlipidemia, especially nephrotic syndrome, should be investigated. In the presence of chronic renal failure and hypoalbuminemia, the fenofibrate dose should be adjusted. Physicians should be aware of the potential toxicities of fenofibrate, and patients should be informed about its potential side effects.
Yuzuncu Yil University, Medical Faculty, Department of Internal Medicine, Van, Turkey. drfme@yahoo.com
Fatih Mehmet
FM
Erdur
Yasemin Usul
YU
Soyoral
Habib
H
Emre
Huseyin
H
Begenik
Esra Turan
ET
Canbaz
Reha
R
Erkoc
D000328:Adult; D005221:Fatigue / Q000175:diagnosis; D011345:Fenofibrate / Q000009:adverse effects* / Q000494:pharmacology*; D006801:Humans; D006973:Hypertension / Q000150:complications; D034141:Hypoalbuminemia / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000009:adverse effects* / Q000494:pharmacology*; D007676:Kidney Failure, Chronic / Q000188:drug therapy*; D008297:Male; D012206:Rhabdomyolysis / Q000188:drug therapy*; D016896:Treatment Outcome
D000960:Hypolipidemic Agents; D011345:Fenofibrate