The Histone Database: an integrated resource for histones and histone fold-containing proteins.
Eukaryotic chromatin is composed of DNA and protein components-core histones-that act to compactly pack the DNA into nucleosomes, the fundamental building blocks of chromatin. These nucleosomes are connected to adjacent nucleosomes by linker histones. Nucleosomes are highly dynamic and, through various core histone post-translational modifications and incorporation of diverse histone variants, can serve as epigenetic marks to control processes such as gene expression and recombination. The Histone Sequence Database is a curated collection of sequences and structures of histones and non-histone proteins containing histone folds, assembled from major public databases. Here, we report a substantial increase in the number of sequences and taxonomic coverage for histone and histone fold-containing proteins available in the database. Additionally, the database now contains an expanded dataset that includes archaeal histone sequences. The database also provides comprehensive multiple sequence alignments for each of the four core histones (H2A, H2B, H3 and H4), the linker histones (H1/H5) and the archaeal histones. The database also includes current information on solved histone fold-containing structures. The Histone Sequence Database is an inclusive resource for the analysis of chromatin structure and function focused on histones and histone fold-containing proteins.
Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, MSC 6075, Bethesda, MD 20894-6075, USA. marino@ncbi.nlm.nih.gov
Leonardo
L
Mariño-Ramírez
Kevin M
KM
Levine
Mario
M
Morales
Suiyuan
S
Zhang
R Travis
RT
Moreland
Andreas D
AD
Baxevanis
David
D
Landsman
D000595:Amino Acid Sequence; D001105:Archaea / Q000235:genetics; D019295:Computational Biology / Q000379:methods*; D030541:Databases, Genetic; D006657:Histones / Q000737:chemistry* / Q000235:genetics*; D020407:Internet; D011487:Protein Conformation; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry*; D012984:Software
D006657:Histones; D011506:Proteins