Sodium selenite attenuated cisplatin-induced toxicity in rats: role of electrolytes homeostasis.
Sodium selenite (1 mg/kg body weight, ip) for 10 consecutive days treatment showed marked increase in intra-erythrocytes K+ and plasma Na+ level while slight increase in Na+ K+ ATPase level. No mortality was observed at this dose of sodium selenite. However, sodium selenite pretreatment partially restored the Na+ K+ ATPase and intra-erythorcytes and plasma sodium level, while completely restored the intra-erythrocytes K+ and plasma Mg2+ level. No change was observed in plasma Ca2+ level. Thus sodium selenite successively attenuated the Cisplatin-induced electrolytes alterations and toxicity by exerting the stress response of sodium.
Biophysics Research Unit, Department of Biochemistry, University of Karachi 75270, Pakistan. shafaqnoori@hotmail.com
Shafaq
S
Noori
Tabassum
T
Mahboob
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D002945:Cisplatin / Q000633:toxicity*; D004573:Electrolytes / Q000097:blood*; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D006706:Homeostasis / Q000187:drug effects*; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D018038:Sodium Selenite / Q000008:administration & dosage / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D000975:Antioxidants; D004573:Electrolytes; D018038:Sodium Selenite; D002945:Cisplatin