Highly selective nickel-catalyzed methyl-carboxylation of homopropargylic alcohols for α-alkylidene-γ-butyrolactones.
A first practical Ni(0)-catalyzed highly stereoselective methyl-carboxylation of homopropargylic alcohols with ZnMe(2) and CO(2) for the efficient synthesis of α-alkylidene-γ-butyrolactones is described. The reaction may be applied to other alkynols.
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, PR China.
Suhua
S
Li
Shengming
S
Ma