Gender differences in the effects of methylphenidate on energy intake in young adults: a preliminary study.
The present study examined gender differences in response to methylphenidate (MPH) on energy intake and macronutrient preference. Twelve adults (6 men, 6 women) were given placebo or short-acting MPH (0.5 mg/kg) in a randomized, double blind, placebo-controlled crossover fashion. One hour after drug administration, appetite sensations and the relative reinforcing value of energy-dense snack food were measured, followed immediately by energy intake and macronutrient preference during a buffet lunch. Relative to placebo, men exhibited a significantly greater reduction in energy intake, fat intake, and carbohydrate intake after MPH administration compared with women. Future research is needed to verify these initial findings.
Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada. ggoldfield@cheo.on.ca
Gary S
GS
Goldfield
Claudio
C
Lorello
Jameason
J
Cameron
Jean-Philippe
JP
Chaput
D000328:Adult; D001066:Appetite / Q000187:drug effects*; D001067:Appetite Depressants / Q000494:pharmacology* / Q000627:therapeutic use; D015992:Body Mass Index; D000697:Central Nervous System Stimulants / Q000494:pharmacology / Q000627:therapeutic use; D018592:Cross-Over Studies; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D004311:Double-Blind Method; D002149:Energy Intake / Q000187:drug effects*; D005260:Female; D005518:Food Preferences / Q000187:drug effects / Q000523:psychology; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology* / Q000627:therapeutic use; D050177:Overweight / Q000188:drug therapy / Q000523:psychology; D010865:Pilot Projects; D012054:Reinforcement, Psychology; D012727:Sex Characteristics; D055815:Young Adult
D001067:Appetite Depressants; D000697:Central Nervous System Stimulants; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D018765:Dopamine Uptake Inhibitors; D008774:Methylphenidate