History of discovery: platelet-derived growth factor.
A growth-promoting activity released from activated platelets, the platelet-derived growth factor, was discovered and characterized while the cellular and molecular mechanisms underlying the formation of the lesions of atherosclerosis were being investigated. This review provides a personal account of the different challenges we faced 3 decades ago in this undertaking and describes how our path was influenced by our focus on a disease process and by the evolving general understanding of the molecular effectors of cell proliferation.
Department of Pathology, University of Washington School of Medicine, Seattle, WA 98109, USA. bp@u.washington.edu
Daniel F
DF
Bowen-Pope
Elaine W
EW
Raines
D049109:Cell Proliferation; D049673:History, 20th Century; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000473:pathology / Q000503:physiopathology; D010982:Platelet-Derived Growth Factor / Q000266:history* / Q000502:physiology*; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D017479:Receptors, Platelet-Derived Growth Factor / Q000502:physiology; D014652:Vascular Diseases / Q000473:pathology / Q000503:physiopathology*
D010982:Platelet-Derived Growth Factor; D011505:Protein-Tyrosine Kinases; D017479:Receptors, Platelet-Derived Growth Factor