Mycobacterium tuberculosis "Beijing" epidemics: a race against mutations?
Multi Drug Resistant Tuberculosis Beijing strains exhibit different drug-resistance mutations (DRM) in different locations. By comparing DRM in Beijing reported from Tuberculosis endemic and epidemic locations, we propose that DRM selected in a population cannot tolerate biologically available drugs in different populations resulting in further evolution through novel DRM.
The Foundation For Medical Research, 84-A, R.G.Thadani Marg, Worli, Mumbai 400018, India.
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P
Bhatter
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Chatterjee
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Mistry
D000995:Antitubercular Agents / Q000494:pharmacology*; D058872:Epidemics; D006801:Humans; D009154:Mutation / Q000187:drug effects*; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy* / Q000453:epidemiology
D000995:Antitubercular Agents