Sterols for Oxygen: The Metabolic Burden of Microbial SREBP.
In this issue of Molecular Cell, Lee et al. (2011) report a novel mechanism for oxygen-sensing in S. pombe, whereby the 2-OG-Fe(II) dioxygenase Ofd protein regulates both the DNA-binding activity and the degradation of the hypoxia regulated transcription factor, Sre1p.
Metabolic Signaling and Disease Program, Obesity and Diabetes Center, Sanford Burnham Medical Research Institute, Orlando, FL 32827, USA. tosborne@sanfordburnham.org
Timothy F
TF
Osborne