Plant viral epitope display systems for vaccine development.
The 'easiest' vaccines, base on production of neutralizing antibodies, have been made. With the emergence of chronic diseases, vaccine developers have understood the importance to trigger an efficient cellular mediated immune response (CTL response) to respond to this medical need. Several options are currently in development and the utilization of plant virus as vaccine platform for the trigger of a CTL response is considered as an interesting avenue. The highly ordered structures of plant viruses are good triggers of the innate immune system, which in turn, is used to initiate an immune response to a vaccine target. It is likely that plant viruses will play an important role in the development of the vaccine of the futures even if there is still several challenges to face.
Infectious Diseases Research Centre, Pavilion CHUL, Laval University, 2705 Boulevard Laurier, Quebec City, PQ, G1V 4G2, Canada, Denis.Leclerc@crchul.ulaval.ca.
Denis
D
Leclerc
D019677:Artificial Gene Fusion; D036022:Capsid Proteins / Q000235:genetics; D018984:Epitopes, T-Lymphocyte / Q000276:immunology; D006801:Humans; D010942:Plant Viruses / Q000235:genetics*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000235:genetics / Q000276:immunology*
D036022:Capsid Proteins; D018984:Epitopes, T-Lymphocyte; D014614:Vaccines, Synthetic