A study of the relationship between process conditions and mechanical strength of mineralized red algae in the preparation of a marine-derived bone void filler.
Bone void fillers that can enhance biological function to augment skeletal repair have significant therapeutic potential in bone replacement surgery. This work focuses on the development of a unique microporous (0.5-10 microm) marine-derived calcium phosphate bioceramic granule. It was prepared from Corallina officinalis, a mineralized red alga, using a novel manufacturing process. This involved thermal processing, followed by a low pressure-temperature chemical synthesis reaction. The study found that the ability to maintain the unique algal morphology was dependent on the thermal processing conditions. This study investigates the effect of thermal heat treatment on the physiochemical properties of the alga. Thermogravimetric analysis was used to monitor its thermal decomposition. The resultant thermograms indicated the presence of a residual organic phase at temperatures below 500 degrees C and an irreversible solid-state phase transition from mg-rich-calcite to calcium oxide at temperatures over 850 degrees C. Algae and synthetic calcite were evaluated following heat treatment in an air-circulating furnace at temperatures ranging from 400 to 800 degrees C. The highest levels of mass loss occurred between 400-500 degrees C and 700-800 degrees C, which were attributed to the organic and carbonate decomposition respectively. The changes in mechanical strength were quantified using a simple mechanical test, which measured the bulk compressive strength of the algae. The mechanical test used may provide a useful evaluation of the compressive properties of similar bone void fillers that are in granular form. The study concluded that soak temperatures in the range of 600 to 700 degrees C provided the optimum physiochemical properties as a precursor to conversion to hydroxyapatite (HA). At these temperatures, a partial phase transition to calcium oxide occurred and the original skeletal morphology of the alga remained intact.
School of Mechanical and Aerospace Engineering, Queens University of Belfast, Northern Ireland, UK.
P J
PJ
Walsh
G M
GM
Walker
C A
CA
Maggs
F J
FJ
Buchanan
D001672:Biocompatible Materials / Q000737:chemistry*; D001843:Bone Cements / Q000138:chemical synthesis*; D001842:Bone and Bones / Q000473:pathology; D002119:Calcium Carbonate / Q000737:chemistry; D017610:Calcium Compounds / Q000737:chemistry; D002130:Calcium Phosphates / Q000737:chemistry; D017886:Durapatite / Q000737:chemistry; D006358:Hot Temperature; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D010087:Oxides / Q000737:chemistry; D016062:Porosity; D000461:Rhodophyta / Q000737:chemistry*; D023822:Tissue Engineering / Q000379:methods*
D001672:Biocompatible Materials; D001843:Bone Cements; D017610:Calcium Compounds; D002130:Calcium Phosphates; D010087:Oxides; D017886:Durapatite; C016538:lime; D002119:Calcium Carbonate