CF2-containing acetylenephosphonates in heterocyclization reactions: the first synthesis of 2-difluoromethyl azaxanth-3-ylphosphonates.
Acetylenephosphonates carrying the XCF(2) group have been studied in a base-mediated heterocyclization reaction with selected 2-amino-3-formylchromones to give 2-difluoromethyl azaxanth-3-ylphosphonates. The presence of the fluorinated substituent determined the regioselectivity as well as the reactivity of this process.
School of Engineering and Science, Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany.
Blazej
B
Duda
Sergey N
SN
Tverdomed
Gerd-Volker
GV
Röschenthaler
D000480:Alkynes / Q000737:chemistry*; D003500:Cyclization; D005466:Fluorocarbons / Q000737:chemistry*; D015394:Molecular Structure; D063065:Organophosphonates / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D044004:Xanthones / Q000138:chemical synthesis* / Q000737:chemistry
D000480:Alkynes; D005466:Fluorocarbons; D063065:Organophosphonates; D011725:Pyridines; D044004:Xanthones