[Optical coherence tomography applied to vessels: a bright future].
Optical Coherence Tomography (OCT) is a new imaging technique recently applied to coronary and is based on the diffusion and reflection of an infrared spectrum. With a resolution 10 times higher than that of IVUS, it allows an analysis of the atherosclerotic plaque and its components, indicating its possible vulnerable character, and can identify the culprit lesion and the presence of thrombus in the course of acute events. It allows quality control of good apposition of stents to the wall and essentially tracks the downstream dissection. In the longer term, it evaluates the endothelisation and in-stent restenosis. Its scope thus extends to basic research and the pharmaceutical industry where it plays a new reference tool in the monitoring of atherosclerotic plaques and stents with drug treatment. This invasive imaging technique is limited by its cost and artifacts but new generation OCT can better overcome them. The OCT appears as a promising intravascular imaging technique whose feasibility and clinical applications, however, require confirmation by randomized clinical trials to better define its place in the cardiac catheterization lab.
Service de cardiologie de l'hôpital d'instruction des armées du Val-de-Grâce, Paris, France.
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Cambon
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Schiano
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F
Barbou
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S
Milouchi
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Monségu
D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000628:therapy; D023903:Coronary Restenosis / Q000175:diagnosis*; D003331:Coronary Vessels / Q000473:pathology*; D003937:Diagnosis, Differential; D054855:Drug-Eluting Stents; D004730:Endothelium, Vascular / Q000473:pathology*; D005240:Feasibility Studies; D006801:Humans; D058226:Plaque, Atherosclerotic / Q000473:pathology*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000379:methods / Q000639:trends