Functional magnetic resonance imaging of working memory and response inhibition in children with mild traumatic brain injury.
The current pilot study examined functional magnetic resonance imaging (fMRI) activation in children with mild traumatic brain injury (mTBI) during tasks of working memory and inhibitory control, both of which are vulnerable to impairment following mTBI. Thirteen children with symptomatic mTBI and a group of controls completed a version of the Tasks of Executive Control (TEC) during fMRI scanning. Both groups showed greater prefrontal activation in response to increased working memory load. Activation patterns did not differ between groups on the working memory aspects of the task, but children with mTBI showed greater activation in the posterior cerebellum with the addition of a demand for inhibitory control. Children with mTBI showed greater impairment on symptom report and "real world" measures of executive functioning, but not on traditional "paper and pencil" tasks. Likewise, cognitive testing did not correlate significantly with imaging results, whereas increased report of post-concussive symptoms were correlated with increased cerebellar activation. Overall, results provide some evidence for the utility of symptom report as an indicator of recovery and the hypothesis that children with mTBI may experience disrupted neural circuitry during recovery. Limitations of the study included a small sample size, wide age range, and lack of in-scanner accuracy data.
Division of Pediatric Neuropsychology, Department of Psychiatry and Behavioral Sciences, Children's National Medical Center, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA.
Lauren S
LS
Krivitzky
Tresa M
TM
Roebuck-Spencer
Robert M
RM
Roth
Kaitlin
K
Blackstone
Chad P
CP
Johnson
Gerard
G
Gioia
D000293:Adolescent; D001921:Brain / Q000098:blood supply*; D001930:Brain Injuries / Q000150:complications / Q000473:pathology / Q000523:psychology; D001931:Brain Mapping; D002648:Child; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D056344:Executive Function; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007266:Inhibition, Psychological; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000209:etiology*; D008570:Memory, Short-Term / Q000502:physiology*; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood
D010100:Oxygen