BRCA1 forks over new roles in DNA-damage response- before and beyond the breaks.
In this issue, Pathania et al. (2011) report the involvement of BRCA1 in ultraviolet (UV)-damage response at stalled replication forks, which extends the function of BRCA1 beyond its established role in the repair of DNA- double-strand breaks (DSBs), raising the complexity of how this tumor suppressor maintains genomic stability.
Departments of Experimental Radiation Oncology and Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. leili@mdanderson.org
Lei
L
Li