Impact of inosine triphosphatase gene variants on the risk of anemia in HIV/hepatitis C virus-coinfected patients treated for chronic hepatitis C.
The role of rs1127354/rs7270101 alleles at the inosine triphosphatase (ITPA) gene on ribavirin-induced anemia was assessed in 74 patients with hepatitis C virus and human immunodeficiency virus coinfection. Anemia developed in 80% of patients with normal ITPA activity compared with 33% of those with reduced ITPA activity. In contrast, ITPA variants did not influence sustained virological response.
Infectious Diseases Department, Hospital Carlos III, Madrid, Spain.
Norma I
NI
Rallón
Judit
J
Morello
Pablo
P
Labarga
José M
JM
Benito
Sonia
S
Rodríguez-Nóvoa
Eugenia
E
Vispo
Pablo
P
Barreiro
M Ángeles
MÁ
Castro
Koldo
K
Aguirrebengoa
Juan A
JA
Pineda
P
P
Miralles
M Jesús
MJ
Tellez
Joaquín
J
Portu
Celia
C
Miralles
Antonio
A
Ocampo
Vincent
V
Soriano
D000328:Adult; D000740:Anemia / Q000139:chemically induced* / Q000453:epidemiology; D000998:Antiviral Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D019698:Hepatitis C, Chronic / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011755:Pyrophosphatases / Q000235:genetics* / Q000378:metabolism; D012254:Ribavirin / Q000008:administration & dosage / Q000009:adverse effects*; D018570:Risk Assessment; D000097630:Inosine Triphosphatase
D000998:Antiviral Agents; D011755:Pyrophosphatases; D012254:Ribavirin; D000097630:Inosine Triphosphatase