Studying the mononuclear phagocyte system in the molecular age.
The mononuclear phagocyte system (MPS) comprises monocytes, macrophages and dendritic cells. Tissue phagocytes share several cell surface markers, phagocytic capability and myeloid classification; however, the factors that regulate the differentiation, homeostasis and function of macrophages and dendritic cells remain largely unknown. The purpose of this manuscript is to review the tools that are currently available and those that are under development to study the origin and function of mononuclear phagocytes.
Department of Oncological Sciences and Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA.
Andrew
A
Chow
Brian D
BD
Brown
Miriam
M
Merad
D000818:Animals; D002454:Cell Differentiation / Q000276:immunology*; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D020869:Gene Expression Profiling / Q000379:methods; D006801:Humans; D008264:Macrophages / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D009000:Monocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D040901:Proteomics / Q000379:methods; D034622:RNA Interference; D017422:Sequence Analysis, DNA / Q000379:methods