Shigeru Tsuiki: a pioneer in the research fields of complex carbohydrates and protein phosphatases.
Dr Tsuiki made three major contributions during his illustrious career as a biochemist. First, he developed the procedure for mucin isolation from bovine submaxillary glands. His work became the basis for mucin biochemistry. Second, he identified four distinct molecular species of mammalian sialidase. Subsequent studies based on his work led to the discovery that sialidase plays a unique role as an intracellular signalling factor involved in the regulation of a variety of cellular functions. Finally, he established the molecular basis for the diversity of mammalian protein phosphatases through protein purification and molecular cloning. His work prompted the functional studies of protein phosphatases.
Department of Cancer Glycosylation Research, Institute of Molecular Biomembrane and Glycobiology, Tohoku Pharmaceutical University, Komatsushima, Aoba-ku, Sendai, Japan.
Taeko
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Miyagi
Kunimi
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Kikuchi
Shinri
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Tamura
D000818:Animals; D050260:Carbohydrate Metabolism; D002241:Carbohydrates; D002417:Cattle; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics / Q000378:metabolism; D009439:Neuraminidase / Q000235:genetics / Q000378:metabolism; D010749:Phosphoprotein Phosphatases / Q000235:genetics / Q000378:metabolism*; D011173:Portraits as Topic
D002241:Carbohydrates; D010749:Phosphoprotein Phosphatases; D009439:Neuraminidase