Effect of Da-Cheng-Qi-Tang on gastrointestinal motility in patients undergoing laparotomy.
OBJECTIVE
The aim of this study was to investigate the effect of Da-Cheng-Qi-Tang (DCQT) on the gastrointestinal motility after abdominal surgery in humans.


METHODS
Thirty-three patients with abdominal surgery and 36 patients with cholecystectomy were divided into DCQT and control groups at random. Electrogastrography (EGG) and antroduodenojejunal manometry were performed and the level of plasma ghrelin were measured by ELISA.


RESULTS
On the operative day, the ratio of EGG normal slow waves in DCQT group was higher than in control group (p<0.05). The power of EGG in DCQT group was higher than in control group on the 2nd and 3rd postoperative day (p<0.05). The percentage of normal bowel peristalsis was significantly higher in the DCQT group than in control group (p<0.01). On the 1st and 2nd postoperative day, the power of Phase III of migrating motor complex (MMC) in the proximal jejunum in DCQT group was significantly higher than in control group (p<0.05). On the 3rd and 5th postoperative day, the plasma ghrelin level in the DCQT group was significantly higher than in the control group (p<0.05).


CONCLUSIONS
DCQT could improve gastric dysrythmia, enhance gastrointestinal motility and adjust the synchronized recovery of the alimentary tract and increase plasma ghrelin after abdominal surgery.
Department of General Surgery, The General Hospital of Tianjin Medical University, Tianjin, China. simpbart@yahoo.cn
Wang
W
Jian
Liu
L
Heng
Qi Qing
QQ
Hui
D000328:Adult; D000368:Aged; D004365:Drugs, Chinese Herbal; D005769:Gastrointestinal Motility; D054439:Ghrelin / Q000097:blood; D006801:Humans; D007813:Laparotomy; D008875:Middle Aged; D016065:Myoelectric Complex, Migrating; D010528:Peristalsis; D010936:Plant Extracts
D004365:Drugs, Chinese Herbal; D054439:Ghrelin; D010936:Plant Extracts; C477169:dachengqi decoction