Time trends in testicular cancer in Croatia 1983-2007: rapid increases in incidence, no declines in mortality.
Testicular cancer, although a rare malignancy, represents the most common cancer in young male populations of Western origin. While increasing incidence trends of testicular cancer have been reported, mortality is declining in many high-resource settings. Using national data from the Croatian National Cancer Registry for the period 1983-2007, time trends were analysed by joinpoint regression and Age-Period-Cohort models. The present study is the first to analyse the testicular cancer trends in the Croatian population. Over the 25-year period, a mean number of 89 incident cases and 13 deaths were reported annually. The observed mean annual increases in age-standardised rates were 7.0% for incidence and 1.6% for mortality, with no abrupt linear changes (joinpoints) identified. The incidence rates of testicular cancer incidence have been steeply increasing in successive cohorts born since the mid-1930s. The rapid rise in testicular cancer incidence in the Croatian population appears to be one of the highest rates of increase recorded in Europe and worldwide. The lack of decline in the mortality rates over time, while based on relatively few deaths, highlights a need for improvements in diagnostics and management of therapy in Croatia in order to improve the survival and quality-of-life of testicular cancer patients.
Laboratory for Epigenetics and Molecular Medicine, Department of Medical Biology, University of Zagreb Medical School, Zagreb, Croatia.
Nino
N
Sincic
Tomislav
T
Kulis
Ariana
A
Znaor
Freddie
F
Bray
D000293:Adolescent; D000328:Adult; D017523:Croatia / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016019:Survival Analysis; D013736:Testicular Neoplasms / Q000453:epidemiology* / Q000401:mortality; D055815:Young Adult