Human muscle-derived stem cells. Effectiveness in animal models of faecal incontinence. Research scheduling.
Researchers believe that human muscle-derived cells are able to restore leak-point pressure to normal levels by differentiating into new muscle fibres that prevent anal sphincter muscle atrophy. Laboratory data are needed to identify exactly how these cells work to regenerate muscle. The objective of this study is to test whether stem cells can be employed to treat internal anal sphincter (IAS) injuries in humans; to this end, this work will use a two-step process to study: first, the effectiveness of the treatment in a sample of animals with artificial injuries to the IAS and then to verify the results in a population of selected humans affected by pathology.
Department of General Surgery, Sapienza, University of Rome, Italy.
M
M
Mongardini
A
A
Lisi
M
M
Giofrè
M
M
Ledda
S
S
Grimaldi
M
M
Scarnò
A
A
Trucchia
K A
KA
Kyriacou
A K
AK
Kyriacou
D
D
Badiali
F
F
Custureri
D001003:Anal Canal / Q000503:physiopathology / Q000601:surgery; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured / Q000187:drug effects; D036101:Cord Blood Stem Cell Transplantation; D003907:Dexamethasone / Q000494:pharmacology; D005242:Fecal Incontinence / Q000601:surgery*; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D045164:Mesenchymal Stem Cell Transplantation; D023421:Models, Animal; D024510:Muscle Development / Q000187:drug effects; D018482:Muscle, Skeletal / Q000166:cytology; D051381:Rats; D011922:Rats, Mutant Strains; D017208:Rats, Wistar; D012038:Regeneration; D032496:Satellite Cells, Skeletal Muscle / Q000502:physiology; D016511:Severe Combined Immunodeficiency; D014183:Transplantation, Heterologous
D003907:Dexamethasone; D006854:Hydrocortisone