Biochemical liver function after partial hepatic resection with or without partial hepatic vascular exclusion.
OBJECTIVE
The aim of the present study was to assess the advantages and disadvantages of liver vascular partial exclusion (LVPE) (liver dysfunction due to ischemia) during liver resection in patients submitted to partial hepatectomy.


METHODS
A total of 114 patients were submitted to partial hepatectomy (minor versus major resections) with LPVE being used in 57 of them but not in the remaining 57. Patient age ranged from 35 to 73 years and 57 % were women. Mitochondrial function was assessed 30 minutes after liver resection in the remnant liver and serum aminotransferases were determined before surgery and for seven days postoperatively. LPVE time ranged from 30 to 60 minutes. Data were analyzed statistically by the Student T test (5 % level of significance).


RESULTS
Mitochondrial function was similar in the minor and major liver resections. The maximum postoperative aminotransferase peak was similar in the groups with and without LPVE.


CONCLUSIONS
LPVE did not induce mitochondrial changes in hepatic tissue in either type of surgery, and aminotransferase levels were similar for patients with and without LPVE. Thus, the results show that LPVE is a safe procedure that does not induce the significant changes typical of ischemia and reperfusion in the liver remnant.
Division of Digestive Surgery, FMRP, USP, Ribeirao Preto, Sao Paulo, Brazil. orlando@fmrp.usp.br
Orlando
O
Castro e Silva
Enio David
ED
Mente
Ajith Kumar
AK
Sankarankutty
Maria Eliza Jordani
ME
Souza
Maria Cecília Jordani
MC
Gomes
Maria Aparecida Neves Cardoso
MA
Picinato
Clarice Fleury
CF
Fina
Jorge Resende
JR
Lopes
D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D005260:Female; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000201:enzymology / Q000502:physiology* / Q000601:surgery; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000502:physiology*; D011184:Postoperative Period; D013997:Time Factors; D016896:Treatment Outcome
D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase