Lack of antimicrobial resistance in Yersinia pestis isolates from 17 countries in the Americas, Africa, and Asia.
Yersinia pestis is the causative agent of plague, a fulminant disease that is often fatal without antimicrobial treatment. Plasmid (IncA/C)-mediated multidrug resistance in Y. pestis was reported in 1995 in Madagascar and has generated considerable public health concern, most recently because of the identification of IncA/C multidrug-resistant plasmids in other zoonotic pathogens. Here, we demonstrate no resistance in 392 Y. pestis isolates from 17 countries to eight antimicrobials used for treatment or prophylaxis of plague.
Bacterial Diseases Branch, Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA.
Sandra K
SK
Urich
Linda
L
Chalcraft
Martin E
ME
Schriefer
Brook M
BM
Yockey
Jeannine M
JM
Petersen
D000349:Africa; D000569:Americas; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001208:Asia; D024881:Drug Resistance, Bacterial; D006801:Humans; D008270:Madagascar; D008826:Microbial Sensitivity Tests; D058974:Phylogeography; D010930:Plague / Q000188:drug therapy* / Q000382:microbiology / Q000635:transmission; D010957:Plasmids / Q000235:genetics; D011634:Public Health; D005423:Siphonaptera; D015010:Yersinia pestis / Q000235:genetics* / Q000302:isolation & purification
D000900:Anti-Bacterial Agents