Room temperature asymmetric allylic trifluoromethylation of Morita-Baylis-Hillman carbonates.
(DHQD)(2)PHAL-catalyzed asymmetric allylic trifluoromethylation of Morita-Baylis-Hillman adducts using a Rupert-Prakash reagent is reported. This transformation provided the S(N)2' trifluoromethylated products with good yields and excellent enantioselectivities at room temperature. It was also found that the reaction could be accelerated using acetonitrile as cosolvent.
China Novartis Institutes for BioMedical Research Co. Ltd., Building 8, lane 898 Halei road, Shanghai 201203, China.
Yun
Y
Li
Fang
F
Liang
Qian
Q
Li
Yao-chang
YC
Xu
Quan-Rui
QR
Wang
Lei
L
Jiang
D002254:Carbonates / Q000737:chemistry*; D002384:Catalysis; D017611:Fluorine Compounds / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure; D013237:Stereoisomerism; D013696:Temperature
D002254:Carbonates; D017611:Fluorine Compounds