Ability of spectral domain optical coherence tomography peripapillary retinal nerve fiber layer thickness measurements to identify early glaucoma.
OBJECTIVE
To evaluate the ability of spectral domain optical coherence tomography (OCT) peripapillary retinal nerve fiber layer thickness (RNFLT) parameters to distinguish normal eyes from those with early glaucoma in Asian Indian eyes.


METHODS
Observational cross-sectional study.


METHODS
One hundred and seventy eight eyes (83 glaucoma patients and 95 age matched healthy subjects) of subjects more than 40 years of age were included in the study. All subjects underwent RNFLT measurement with spectral OCT/ scanning laser ophthalmoscope (SLO) after dilatation. Sensitivity, specificity and area under the receiving operating characteristic curve (AROC) were calculated for various OCT peripapillary RNFL parameters.


RESULTS
The mean RNFLT in healthy subjects and patients with early glaucoma were 105.7 ± 5.1 μm and 90.7 ± 7.5 μm, respectively. The largest AROC was found for 12 o'clock- hour (0.98), average (0.96) and superior quadrant RNFLT (0.9). When target specificity was set at ≥ 90% and ≥ 80%, the parameters with highest sensitivity were 12 o'clock -hour (91.6%), average RNFLT (85.3%) and 12 o' clock- hour (96.8 %), average RNFLT (94.7%) respectively.


CONCLUSIONS
Our study showed good ability of spectral OCT/ SLO to differentiate normal eyes from patients with early glaucoma and hence it may serve as an useful adjunct for early diagnosis of glaucoma.
Department of Glaucoma, Pushpagiri Eye Institute, 241, Uma Plaza, 10-2-342, Road No 9, West Marredpally, Secunderabad-500 026, Andhra Pradesh, India. tarannummansoori@yahoo.com
Tarannum
T
Mansoori
Kalluri
K
Viswanath
Nagalla
N
Balakrishna
D000368:Aged; D003430:Cross-Sectional Studies; D042241:Early Diagnosis; D005260:Female; D005901:Glaucoma / Q000208:ethnology / Q000473:pathology*; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012160:Retina / Q000473:pathology*; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000379:methods*