[Analysis of HLA-DQB1 polymorphism for patients with allergic rhinitis of Uygur and Han people in Xinjiang].
OBJECTIVE
To investigate the association of HLA-DQB1 alleles and artemisia pollen allergic patients of Han and Uygur people in the Xinjiang area.


METHODS
PCR-SSP (sequence-specific primer polymerase chain reaction) were used to test fifty Uygur and fifty Han people with allergic rhinitis with hypersensitivity to artemisia pollen in the Xinjiang area. Fifty normal Uygur and fifty normal Han people in the Xinjiang region were enrolled in the control group.


RESULTS
The frequency of HLA-DQB1 * 05 in the Uygur group with allergic rhinitis was significantly higher (19.4%) than that in the Uygur control group (7%) (P < 0.05). There were no significant difference between in the allergic rhinitis group and in the control group.


CONCLUSIONS
HLA-DQB1 * 05 might be the susceptibility genes of the Uygur patients with allergic rhinitis in the Xinjiang area.
Department of Otolaryngology, First Hospital Affiliated Xinjiang Medical University, Urumqi 830063, China. hzhang1106@yahoo.com.cn
Zhongtao
Z
Cui
Hua
H
Zhang
Yunlian
Y
Liu
Yuping
Y
Yang
Yangbing
Y
Xiang
D000293:Adolescent; D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005006:Ethnicity; D005260:Female; D005787:Gene Frequency; D059866:HLA-DQ beta-Chains / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D006255:Rhinitis, Allergic, Seasonal / Q000235:genetics*; D055815:Young Adult
D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen