Supervised exercise training counterbalances the adverse effects of insulin therapy in overweight/obese subjects with type 2 diabetes.
OBJECTIVE
To examine the effect of supervised exercise on traditional and nontraditional cardiovascular risk factors in sedentary, overweight/obese insulin-treated subjects with type 2 diabetes from the Italian Diabetes Exercise Study (IDES).


METHODS
The study randomized 73 insulin-treated patients to twice weekly supervised aerobic and resistance training plus structured exercise counseling (EXE) or to counseling alone (CON) for 12 months. Clinical and laboratory parameters were assessed at baseline and at the end of the study.


RESULTS
The volume of physical activity was significantly higher in the EXE versus the CON group. Values for hemoglobin A(1c), BMI, waist circumference, high-sensitivity C-reactive protein, blood pressure, LDL cholesterol, and the coronary heart disease risk score were significantly reduced only in the EXE group. No major adverse events were observed.


CONCLUSIONS
In insulin-treated subjects with type 2 diabetes, supervised exercise is safe and effective in improving glycemic control and markers of adiposity and inflammation, thus counterbalancing the adverse effects of insulin on these parameters.
Department of Clinical and Molecular Medicine, La Sapienza University, Rome, Italy. balducci@esinet.it
Stefano
S
Balducci
Silvano
S
Zanuso
Patrizia
P
Cardelli
Gerardo
G
Salerno
Sara
S
Fallucca
Antonio
A
Nicolucci
Giuseppe
G
Pugliese
D000368:Aged; D001794:Blood Pressure; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D003376:Counseling; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy / Q000534:rehabilitation*; D015444:Exercise; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000534:rehabilitation*; D050177:Overweight / Q000534:rehabilitation*; D055070:Resistance Training; D012307:Risk Factors; D055105:Waist Circumference
D002097:C-Reactive Protein; D006442:Glycated Hemoglobin; D007328:Insulin