Posterior fossa syndrome in an adult patient following surgical evacuation of an intracerebellar haematoma.
The posterior fossa syndrome (PFS) consists of transient cerebellar mutism, cognitive symptoms and neurobehavioural abnormalities that typically develop in children following posterior fossa tumour resection. Although PFS has been documented in more than 350 paediatric cases, reports of adult patients with a vascular aetiology are extremely rare. In addition, the pathophysiological substrate of the syndrome remains unclear. We report an adult patient with PFS after surgical evacuation of a cerebellar bleeding. After 45 days of (akinetic) mutism, the patient's cognitive and behavioural profile closely resembled the "cerebellar cognitive-affective syndrome". A quantified SPECT study showed perfusional deficits in the anatomoclinically suspected supratentorial areas, subserving language dynamics, executive functioning, spatial cognition and affective regulation. We hypothesize that cerebello-cerebral diaschisis might be an important pathophysiological mechanism underlying akinetic mutism, cognitive deficits and behavioural-affective changes in adult patients with PFS.
Department of Experimental Psychology, University of Ghent, Ghent, Belgium.
Hyo Jung
HJ
De Smet
Peter
P
Mariën
D002526:Cerebellar Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D002543:Cerebral Hemorrhage / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D003388:Cranial Fossa, Posterior / Q000000981:diagnostic imaging / Q000473:pathology*; D003545:Cysteine / Q000031:analogs & derivatives; D006801:Humans; D007360:Intelligence; D008297:Male; D008875:Middle Aged; D009155:Mutism / Q000209:etiology; D009483:Neuropsychological Tests; D015609:Organotechnetium Compounds; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D019275:Radiopharmaceuticals; D013064:Speech Disorders / Q000209:etiology; D020521:Stroke / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery; D015899:Tomography, Emission-Computed, Single-Photon; D014705:Verbal Behavior; D014888:Wechsler Scales
D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C059659:technetium Tc 99m bicisate; D003545:Cysteine