Lessons from the past: opportunities to improve childhood cancer survivor care through outcomes investigations of historical therapeutic approaches for pediatric hematological malignancies.
Investigations of long-term outcomes have been instrumental in designing safer and more effective contemporary therapies for pediatric hematological malignancies. Despite the significant therapeutic changes that have occurred over the last five decades, therapy modifications largely represent refinements of treatment protocols using agents and modalities that have been available for more than 30 years. This review summarizes major trends in the evolution of treatment of pediatric hematological malignancies since 1960 to support the relevance of the study of late effects of historical therapeutic approaches to the design and evaluation of contemporary treatment protocols and the follow-up of present-day survivors.
Department of Oncology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105, USA. melissa.hudson@stjude.org
Melissa M
MM
Hudson
Joseph P
JP
Neglia
William G
WG
Woods
John T
JT
Sandlund
Ching-Hon
CH
Pui
Larry E
LE
Kun
Leslie L
LL
Robison
Daniel M
DM
Green
D024221:Antineoplastic Protocols; D002648:Child; D003131:Combined Modality Therapy / Q000639:trends; D019337:Hematologic Neoplasms / Q000628:therapy*; D006689:Hodgkin Disease / Q000628:therapy; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000628:therapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy; D017741:Survivors; D016896:Treatment Outcome