Two-site automated chemiluminescent assay for measurement of immunoreactive renin.
Measurement of renin is important for the clinical assessment of hypertensive patients and for the screening for primary aldosteronism. The aim of this study was to evaluate the performances of an automated immunoassay for measurement of immunoreactive renin. Functional sensitivity, in vitro stability, and reference values were determined. Method comparison with the plasma renin activity assay was also performed. Our results demonstrate that the Liaison(®) direct renin assay may assist the clinician in the assessment of hypertensive patients and in the screening for primary aldosteronism.
Pôle de recherche en Endocrinologie, Diabète et Nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St-Luc and Université Catholique de Louvain ,  Brussels ,  Belgium.
D
D
Gruson
D
D
Maisin
P
P
Lison
D
D
Maiter
A
A
Persu
D015415:Biomarkers / Q000097:blood; D003937:Diagnosis, Differential; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood / Q000175:diagnosis; D006973:Hypertension / Q000097:blood / Q000175:diagnosis; D007118:Immunoassay / Q000379:methods*; D008163:Luminescent Measurements / Q000379:methods*; D008403:Mass Screening; D012016:Reference Values; D012083:Renin / Q000097:blood* / Q000276:immunology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D015415:Biomarkers; D012083:Renin