[Causes of early mortality after liver transplantation: a twenty-years single centre experience].
OBJECTIVE
To define the causes of mortality of patients who died within the first three months after a liver transplantation.


METHODS
Retrospective, observational, and single centre study.


METHODS
Between March 1989 and July 2010, all patients who died within three months after a liver transplantation were included. Demographic characteristics, preoperative and peroperative data, donor characteristics, postoperative complications and causes of mortality were collected.


RESULTS
Among the 788 performed liver transplantations, 76 patients died in intensive care unit (11%). The main indications of liver transplantation were alcoholic cirrhosis (30%), hepatitis C (28%), hepatocarcinoma (15%), primitive or secondary biliary cirrhosis (10%). Fifty percent of the patients were categorized as Child C. The main causes of death were non-function or dysfunction with retransplantation contra-indication graft (18%), sepsis (18%), neurological complications (12%), hemorrhagic shock (13%), (9%), multiorgan failures (5%), cardiac complications (6%).


CONCLUSIONS
In this study, the main causes of mortality were infectious, neurological and hemorrhagic. These results emphasize the necessity for better control of sepsis, haemorrhage and immunosupressors.
Département d'anesthésie-réanimation, hôpital Saint-Éloi, CHU de Montpellier, 80, avenue Augustin-Fliche, 34295 Montpellier, France.
B
B
Jung
M
M
Cisse
G
G
Chanques
E
E
Arsac
M
M
Bismuth
F
F
Panaro
P-F
PF
Perrigault
B
B
Souche
B
B
Gallix
D
D
Verzilli
J-M
JM
Delay
F
F
Navarro
G-P
GP
Pageaux
S
S
Jaber
D002423:Cause of Death; D005260:Female; D006801:Humans; D016031:Liver Transplantation / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors