Independent association of TG/HDL-C with urinary albumin excretion in normotensive subjects in a rural Korean population.
BACKGROUND
The ratio of triglycerides (TG, mg/dl) to high-density lipoprotein cholesterol (HDL-C, mg/dl) is a reliable indicator of insulin resistance and atherosclerotic diseases in some ethnic groups. This study is performed to examine the association between TG/HDL-C and albuminuria.


METHODS
This cross-sectional study included 9094 adult subjects (4091 men, 5003 women) who were enrolled in the Korean Genomic Rural Cohort (KGRC) and aged 40 years or more. Albuminuria was defined as a urine albumin/creatinine ratio ≥ 30 mg/g. Participants were categorized into TG/HDL-C quartile.


RESULTS
Compared to the lowest TG/HDL-C quartile (<1.94 in men, <1.71 in women), the odds ratios (ORs) for albuminuria in participants who were categorized in the highest TG/HDL-C quartile (≥ 4.98 in men, ≥ 4.20 in women) were 1.30 (95% CI: 0.97-1.75) and 1.36 (1.03-1.79) in men and women, respectively, when adjusted for blood pressure and other covariates. In normotensive men and women, the ORs for albuminuria in the highest TG/HDL-C quartile were 1.58 (1.04-2.39) and 1.68 (1.15-2.45), respectively, even after fully adjusted. In contrast, TG/HDL-C was not associated with albuminuria in hypertensive subjects.


CONCLUSIONS
TG/HDL-C was independently associated with increased prevalence of albuminuria in normotensive rural Korean subjects aged 40 years or more in KGRC.
Department of Family Medicine, Gangnam Severance Hospital, College of Medicine, Yonsei University, Seoul, South Korea.
Hee-Taik
HT
Kang
Jong-Koo
JK
Kim
Jang-Young
JY
Kim
John A
JA
Linton
Jin-Ha
JH
Yoon
Sang-Baek
SB
Koh
D000328:Adult; D000419:Albuminuria / Q000503:physiopathology / Q000652:urine*; D001794:Blood Pressure; D008076:Cholesterol, HDL / Q000097:blood*; D003404:Creatinine / Q000652:urine; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D056910:Republic of Korea; D012424:Rural Population; D014280:Triglycerides / Q000097:blood*
D008076:Cholesterol, HDL; D014280:Triglycerides; D003404:Creatinine