Current trends in management of hepatitis B virus reactivation in the biologic therapy era.
Hepatitis B virus (HBV) reactivation represents an emerging cause of liver disease in patients undergoing treatment with biologic agents. In particular, the risk of HBV reactivation is heightened by the use monoclonal antibodies, such as rituximab (anti-CD20) and alemtuzumab (anti-CD52) that cause profound and long-lasting immunosuppression. Emerging data indicate that HBV reactivation could also develop following the use of other biologic agents, such as tumor necrosis factor (TNF)-α inhibitors. When HBV reactivation is diagnosed, it is mandatory to suspend biologic treatment and start antiviral agents immediately. However, pre-emptive antiviral therapy prior to monoclonal antibody administration is crucial in preventing HBV reactivation and its clinical consequences. Several lines of evidence have shown that risk of HBV reactivation is greatly reduced by the identification of high-risk patients and the use of prophylactic antiviral therapy. In this article, we discuss current trends in the management of HBV reactivation in immunosuppressed patients receiving biologic therapy, such as rituximab, alemtuzumab and TNF-α antagonists.
Infectious Diseases Unit, Fondazione Eleonora Lorillard Spencer Cenci, Sapienza University, SM Goretti Hospital, 04100 Latina, Italy. claudio.mastroianni@uniroma1.it
Claudio M
CM
Mastroianni
Miriam
M
Lichtner
Rita
R
Citton
Cosmo
C
Del Borgo
Angela
A
Rago
Helene
H
Martini
Giuseppe
G
Cimino
Vincenzo
V
Vullo
D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use; D015703:Antigens, CD / Q000276:immunology; D000998:Antiviral Agents / Q000276:immunology / Q000627:therapeutic use*; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control* / Q000628:therapy*; D006515:Hepatitis B virus / Q000502:physiology*; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D014775:Virus Activation / Q000502:physiology*
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000998:Antiviral Agents; D014409:Tumor Necrosis Factor-alpha