Coenzyme Q10 deficiency in septic shock patients.
Donnino and colleagues provide new insights into the field of oxidative stress and mitochondrial dysfunction during septic shock. These authors suggest a coenzyme Q10 (CoQ10) deficiency in patients with septic shock. Larger prospective observational trials measuring CoQ10 in patients with septic shock are required to confirm the possibility of CoQ10 depletion. This study is a new step toward a study testing CoQ10 as a potential therapeutic agent for patients with septic shock.
Assistance Publique - Hôpitaux de Paris, Hôpital Bicêtre, Département d'Anesthésie-Réanimation, EA 3509 Université Paris Sud XI, France F-94275, Le Kremlin-Bicêtre, France.
Laurent
L
Dupic
Olivier
O
Huet
Jacques
J
Duranteau
D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications*; D008297:Male; D012772:Shock, Septic / Q000503:physiopathology*; D014451:Ubiquinone / Q000031:analogs & derivatives*; D014815:Vitamins / Q000097:blood*
D014815:Vitamins; D014451:Ubiquinone