The role of the gut/brain axis in modulating food intake.
Peptide hormones released from the gastrointestinal tract communicate information about the current state of energy balance to the brain. These hormones regulate appetite and energy expenditure via the vagus nerve or by acting on key brain regions implicated in energy homeostasis such as the hypothalamus and brainstem. This review gives an overview of the main gut hormones implicated in the regulation of food intake. Research in this area has provided novel targets for the pharmacological treatment of obesity. This article is part of a Special Issue entitled 'Central Control Food Intake'
Section of Investigative Medicine, Imperial College London, London W12 0NN, UK.
Amir H
AH
Sam
Rachel C
RC
Troke
Tricia M
TM
Tan
Gavin A
GA
Bewick
D000818:Animals; D001921:Brain / Q000502:physiology*; D004435:Eating / Q000502:physiology*; D041981:Gastrointestinal Tract / Q000294:innervation / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D009479:Neuropeptides / Q000378:metabolism; D009765:Obesity / Q000378:metabolism*
D009479:Neuropeptides