Spin-trapping reactions of a novel gauchetype radical trapper G-CYPMPO.
Chemical reactions of a novel gauchetype spin trap, G-CYPMPO (sc-5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphinan-2-yl)-5-methy-1-pyrroline N-oxide, O1-P1-C6-N1 torsion angle = 52.8°), with reactive oxygen species were examined by pulse radiolysis technique with 35 MeV electron beam and by electron spin resonance spectroscopy after (60)Co γ-ray irradiation. The spin-trapping reaction rate constants of G-CYPMPO toward the hydroxyl radical and the hydrated electron were estimated to be (4.2 ± 0.1) × 10(9) and (11.8 ± 0.2) × 10(9) M(-1)s(-1), respectively. Half-lives of the spin adducts, hydroxyl radical, and perhydroxyl radical adducted G-CYPMPO were estimated to be ∼35 and ∼90 min, respectively. A comparison of the results with earlier reports using different radical sources suggests that the purity of the solution and/or the radical generation technique may influence the stability of the spin adducts.
Advanced Science Research Center, Japan Atomic Energy Agency (JAEA), Tokai-mura, Ibaraki, Japan. oka.toshitaka@jaea.go.jp
Toshitaka
T
Oka
Shinichi
S
Yamashita
Masamichi
M
Midorikawa
Seiichi
S
Saiki
Yusa
Y
Muroya
Masato
M
Kamibayashi
Masayuki
M
Yamashita
Kazunori
K
Anzai
Yosuke
Y
Katsumura
D003037:Cobalt Radioisotopes / Q000737:chemistry; D003497:Cyclic N-Oxides / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D005720:Gamma Rays; D017665:Hydroxyl Radical / Q000737:chemistry*; D010545:Peroxides / Q000737:chemistry*; D019097:Spin Trapping
D003037:Cobalt Radioisotopes; D003497:Cyclic N-Oxides; D010545:Peroxides; C571846:sc-5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphinan-2-yl)-5-methy-1-pyrroline N-oxide; C049375:perhydroxyl radical; D017665:Hydroxyl Radical