Biologically active constituents of Aglaia erythrosperma.
From the fruits and leaves of Aglaia erythrosperma (Meliaceae), 10 chemical constituents were isolated and identified, i.e. the dammarane triterpenoids cabraleadiol (1), cabraleahydroxylactone (2), ethyl eichlerianoate (3), eichlerialactone (4), aglinin A (5), cabralealactone (6), the aglaialactone 5,6-desmethylenedioxy-5-methoxy-aglalactone (7), the flavagline 4'-demethoxy-3',4'-methylenedioxy-methyl rocaglate (8) and two coumarins: scoparone and scopoletin. Flavagline 8 exhibited antimalarial activity with an IC(50) value of 7.30 µg mL(-1) and was strongly cytotoxic against small cell lung cancer (NCI-H187), epidermoid carcinoma (KB) and breast cancer (BC) cell lines, with IC(50) values of 2.17, 2.10 and 0.11 µg mL(-1), respectively. Aglinin A (5) displayed moderate cytotoxicity against all the three cancer cell lines, whereas ethyl eichlerianoate (3), cabralealactone (6) and the aglaialactone 7 were exclusively cytotoxic to NCI-H187 cell line. Cabraleahydroxylactone (2) showed antiviral activity against herpes simplex virus type-1 with an IC(50) value of 3.20 µg mL(-1), in comparison with the standard acyclovir (IC(50) = 1.90 µg mL(-1)). When tested for antimycobacterial activity against Mycobacterium tuberculosis H(37)Ra, compounds 1-4 and 6-8 displayed minimum inhibitory concentration in the range of 25-50 µg mL(-1).
Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Jarinporn
J
Phongmaykin
Takuya
T
Kumamoto
Tsutomu
T
Ishikawa
Ekarin
E
Saifah
Rutt
R
Suttisri
D031602:Aglaia / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D000962:Antimalarials / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D000998:Antiviral Agents / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D001572:Benzofurans / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D003374:Coumarins / Q000032:analysis / Q000302:isolation & purification; D003603:Cytotoxins / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010840:Phytosterols / Q000032:analysis / Q000302:isolation & purification; D018515:Plant Leaves / Q000737:chemistry*; D011278:Pregnanes / Q000032:analysis / Q000302:isolation & purification; D013056:Spectrophotometry, Ultraviolet; D013785:Thailand
D000900:Anti-Bacterial Agents; D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D000998:Antiviral Agents; D001572:Benzofurans; D003374:Coumarins; D003603:Cytotoxins; D010840:Phytosterols; D011278:Pregnanes; C430224:cabraleadiol monoacetate