Outcome of Graves' orbitopathy after total thyroid ablation and glucocorticoid treatment: follow-up of a randomized clinical trial.
BACKGROUND
In a previous study, we found that total thyroid ablation (thyroidectomy plus (131)I) is associated with a better outcome of Graves' orbitopathy (GO) compared with thyroidectomy alone, as observed shortly (9 months) after glucocorticoid (GC) treatment.


OBJECTIVE
The objective of the study was to evaluate the outcome of GO in the same patients of the previous study over a longer period of time.


METHODS
This was a follow-up of a randomized study.


METHODS
The study was conducted at a referral center.


METHODS
Fifty-two of 60 original patients with mild to moderate GO participated in the study.


METHODS
Patients randomized into thyroidectomy (TX) or total thyroid ablation and treated with GC were reevaluated in 2010, namely 88.0 ± 17.7 months after GC, having undergone an ophthalmological follow-up in the intermediate period.


METHODS
The main outcome measures included the following: 1) GO outcome; 2) time to GO best possible outcome and to GO improvement; and 3) additional treatments.


RESULTS
GO outcome at the end of the follow-up was similar in the two groups. However, the time required for the best possible outcome to be achieved was longer in the TX group (24 vs. 3 months, P = 0.0436), as was the time required for GO to improve (60 vs. 3 months, P = 0.0344). Additional treatments were given to a similar proportion of patients in each group (TX, 28%, total thyroid ablation, 25.9%), but they affected GO beneficially more often in the TX group (28 vs. 3.7%, P: 0.0412).


CONCLUSIONS
Compared with thyroidectomy alone, total thyroid ablation allows the achievement of the best possible outcome and an improvement of GO within a shorter period of time.
Department of Endocrinology, University of Pisa, Via Paradisa 2, 56100 Pisa, Italy.
Marenza
M
Leo
Claudio
C
Marcocci
Aldo
A
Pinchera
Marco
M
Nardi
Loredana
L
Megna
Roberto
R
Rocchi
Francesco
F
Latrofa
Maria Antonietta
MA
Altea
Barbara
B
Mazzi
Eleonora
E
Sisti
Maria Antonietta
MA
Profilo
Michele
M
Marinò
D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use*; D049970:Graves Ophthalmopathy / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D018828:Immunoglobulins, Thyroid-Stimulating / Q000097:blood; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011788:Quality of Life; D012074:Remission Induction; D013965:Thyroidectomy / Q000379:methods* / Q000534:rehabilitation*; D013997:Time Factors; D016896:Treatment Outcome
D005938:Glucocorticoids; D018828:Immunoglobulins, Thyroid-Stimulating