Organocatalytic enantioselective (3+2) cycloaddition using stable azomethine ylides.
We have developed a highly efficient procedure for carrying out the catalytic enantioselective (3+2) cycloaddition between enals and stable azomethine ylides such as isoquinolinium and phthalizinium methylides. Under the optimized reaction conditions highly substituted chiral pyrroloisoquinolines and pyrrolophthalazines have been obtained in high yields and excellent diastereo- and enantioselectivities.
Department of Organic Chemistry II, UPV/EHU, Bilbao, Spain.
Naiara
N
Fernández
Luisa
L
Carrillo
Jose L
JL
Vicario
Dolores
D
Badía
Efraim
E
Reyes