Heterotopic ossification associated with recombinant human bone morphogenetic protein-2 (infuse) in posterolateral lumbar spine fusion: a case report.
METHODS
A case of heterotopic ossification in the lumbar spine associated with the off-label use of recombinant human bone morphogenetic protein-2 (rhBMP-2) is reported.


OBJECTIVE
To highlight a previously unreported complication of rhBMP-2 use and to review the literature pertinent to the topic.


BACKGROUND
There is no report in the literature regarding a large mass of rhBMP-2-associated heterotopic ossification surrounding the paraspinal musculature.


METHODS
The clinical and radiographical features of this complication and treatment course are presented.


RESULTS
The surgical excision of heterotopic ossification and removal of symptomatic instrumentation have resulted in the patient remaining asymptomatic at 1 year of follow-up examination.


CONCLUSIONS
The reported case adds to the literature of off-label use of rhBMP-2 and the potential for the formation of heterotopic ossification with its use.
Department of Surgery, Section of Orthopaedics, The University of Kansas School of Medicine-Wichita, Wichita, KS 67214, USA. canderson2@kumc.edu
Christopher L
CL
Anderson
M Camden
MC
Whitaker
D000368:Aged; D055396:Bone Morphogenetic Protein 2 / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D017116:Low Back Pain / Q000139:chemically induced* / Q000473:pathology; D008159:Lumbar Vertebrae / Q000473:pathology*; D056687:Off-Label Use; D009999:Ossification, Heterotopic / Q000139:chemically induced* / Q000473:pathology; D013123:Spinal Fusion / Q000009:adverse effects* / Q000379:methods
C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2