Organizing pneumonia associated with oxaliplatin-combined chemotherapy: a case report.
OBJECTIVE
To report a case of oxaliplatin-combined chemotherapy-induced interstitial lung disease.


METHODS
A 57-year-old man was referred complaining of dyspnea and fever after treatment with an oxaliplatin-combined chemotherapeutic agent for metastatic colorectal cancer. Fever development and spontaneous subsidence were observed during the chemotherapeutic course repeatedly until the 9th cycle. A computer-tomographic (CT) scan revealed bilateral, peripherally distributed, patchy consolidation suggestive of an interstitial lung disease. As a confirmative step, video-assisted thoracoscopic surgical biopsy was attempted; the characteristic intraluminal organizing fibrous plug in the bronchioles and alveoli was seen. Corticosteroid therapy was administered, which rapidly improved the patient's symptoms and chest CT findings.


CONCLUSIONS
This case showed that oxaliplatin may be implicated in the etiology of interstitial lung disease, since withdrawal of the drug resulted in improvement of interstitial lung disease.
Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine, 126-1 5-ga Anam-dong, Seongbuk-gu, Seoul, Republic of Korea.
Eun Joo
EJ
Lee
Sang Yeub
SY
Lee
Kwang Ho
KH
In
Chul Hwan
CH
Kim
Sanghoon
S
Park
D000970:Antineoplastic Agents / Q000009:adverse effects*; D004417:Dyspnea; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000009:adverse effects*; D000077150:Oxaliplatin; D012307:Risk Factors; D020775:Thoracic Surgery, Video-Assisted / Q000295:instrumentation
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin