[Circulating citrulline levels: a biomarker for intestinal functionality assessment].
Circulating citrulline is emerging as an innovating biomarker candidate for assessment of intestinal function. Amino acid synthesized by enterocytes of intestinal mucosal, citrulline is not included in proteins or nutrition products and is a precursor for production of arginine by the kidney. Plasma citrulline is, in clinical situation, an established biomarker of enterocyte functional metabolic mass (trophicity) in children and in adult patients due to its high relation to active functional small bowel remnant length in intestinal diseases (short bowel, extensive enteropathies, intestinal toxicity of chemotherapy and radiotherapy. Plasma citrulline concentration (30-50  μmol/L), independent of nutritional status, if less than 10  μmol/L can give an objective threshold for nutrition parenteral use in case of intestinal failure due to enterocyte abnormalities or lack. Its regular dosage allows the monitoring of intestinal function except in case of significant renal failure.
Assistance publique-Hôpitaux de Paris, Hôpital Raymond-Poincaré, Université de Versailles-Saint-Quentin-en-Yvelines, Département de Médecine Aiguë Spécialisée, EA 4497, Garches, France. pascal.crenn@rpc.aphp.fr
Pascal
P
Crenn
Mouna
M
Hanachi
Nathalie
N
Neveux
Luc
L
Cynober
D015415:Biomarkers / Q000032:analysis / Q000097:blood*; D002956:Citrulline / Q000032:analysis / Q000097:blood* / Q000502:physiology; D019411:Clinical Laboratory Techniques / Q000379:methods; D006801:Humans; D007410:Intestinal Diseases / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D007422:Intestines / Q000502:physiology*; D008954:Models, Biological; D009752:Nutritional Status; D012720:Severity of Illness Index
D015415:Biomarkers; D002956:Citrulline