Clamp-crushing vs. radiofrequency-assisted liver resection:changes in liver function tests.
OBJECTIVE
Liver resection is the gold standard in managing patients with metastatic or primary liver cancer. The aim of our study was to compare the traditional clamp-crushing technique to the radiofrequency- assisted liver resection technique in terms of postoperative liver function.


METHODS
Liver function was evaluated preoperatively and on postoperative days 3 and 7. Liver synthetic function parameters (serum albumin level, prothrombin time and international normalized ratio), markers of hepatic injury and necrosis (serum alanine aminotransferase, aspartate aminotransferase and total bilirubin level) and microsomal activity (quantitative lidocaine test) were compared.


RESULTS
Forty three patients completed the study (14 had clamp-crushing and 29 had radiofrequency assisted liver resection). The groups did not differ in demographic characteristics, pre-operative liver function, operative time and perioperative transfusion rate. In postoperative period, there were similar changes in monitored parameters in both groups except albumin levels, that were higher in radiofrequency-assisted liver resection group (p=0.047).


CONCLUSIONS
Both, traditional clamp-crushing technique and radiofrequency assisted liver resection technique, result in similar postoperative changes of most monitored liver function parameters.
School of Medicine, University of Belgrade, Belgrade, Serbia. ivanpalibrk@yahoo.com
Ivan
I
Palibrk
Biljana
B
Milicic
Ljuba
L
Stojiljkovic
Nebojsa
N
Manojlovic
Vladimir
V
Dugalic
Vesna
V
Bumbasirevic
Nevena
N
Kalezic
Marinko
M
Zuvela
Miroslav
M
Milicevic
D000368:Aged; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D017115:Catheter Ablation; D016009:Chi-Square Distribution; D003250:Constriction; D005260:Female; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D008099:Liver / Q000293:injuries / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D008107:Liver Diseases / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D018570:Risk Assessment; D012307:Risk Factors; D055771:Serbia; D013997:Time Factors; D016896:Treatment Outcome
D015415:Biomarkers