Detection of qacA/B in clinical isolates of methicillin-resistant Staphylococcus aureus from a regional healthcare network in the eastern United States.
We describe the clinical, microbiologic, and molecular features of the first series of qacA/B-containing strains of methicillin-resistant Staphylococcus aureus from infected US patients. All qac-carrying strains were clonally diverse, and qacA strains exhibited increased tolerance to chlorhexidine as measured by minimum inhibitory concentrations, minimum bactericidal concentrations, and postexposure colony counts.
Multidrug-Resistant Organism Repository and Surveillance Network, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA. patrick.t.mcgann.ctr@us.army.mil
Patrick
P
McGann
Yoon I
YI
Kwak
Amy
A
Summers
James F
JF
Cummings
Paige E
PE
Waterman
Emil P
EP
Lesho
D000328:Adult; D000368:Aged; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics*; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004219:District of Columbia / Q000453:epidemiology; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D006764:Hospitals, Community; D006784:Hospitals, Teaching; D006801:Humans; D008297:Male; D008396:Maryland / Q000453:epidemiology; D026901:Membrane Transport Proteins / Q000235:genetics*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D046915:Penicillin-Binding Proteins; D060888:Real-Time Polymerase Chain Reaction; D013203:Staphylococcal Infections / Q000453:epidemiology*; D018709:Statistics, Nonparametric; D014768:Virginia / Q000453:epidemiology; D055815:Young Adult
D000891:Anti-Infective Agents, Local; D001426:Bacterial Proteins; C096686:FemA protein, Bacteria; D026901:Membrane Transport Proteins; D046915:Penicillin-Binding Proteins; C099272:QacB protein, Staphylococcus aureus; C487789:mecA protein, Staphylococcus aureus; C068498:qacA protein, Staphylococcus aureus; C010882:chlorhexidine gluconate; D002710:Chlorhexidine