IL-17 producing cells in host defense and atopy.
The roles of IL-17 producing cells have been the subject of significant research in the fields of autoimmunity, host defense, and recently, atopy. A substantial number of genetic disease with disruptions in the IL-17 pathway have been identified and characterized in past few years, not only enhancing our understanding, but also raising new and complex questions. The connection between IL-17 and atopic disease, in particular, is complex, but it merits further study which may ultimately lead to therapies targeting the Th17 pathway in infectious and/or allergic settings.
Laboratory of Allergic Diseases, National Institute for Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, United States. jdmilner@niaid.nih.gov
Joshua D
JD
Milner
D000707:Anaphylaxis / Q000276:immunology; D000818:Animals; D001249:Asthma / Q000276:immunology; D001491:Basophils / Q000166:cytology / Q000276:immunology; D003876:Dermatitis, Atopic / Q000276:immunology*; D006801:Humans; D020381:Interleukin-17 / Q000096:biosynthesis / Q000276:immunology*
D020381:Interleukin-17