Chiral information harvesting in dendritic metallopeptides.
Long-range communication of stereochemical information is common in biological systems, particularly in enzyme-catalysed reactions. Here, we report the remote control of the dynamic chirality of metal centres, coordinated by 2,2'-bipyridine ligands bearing dynamic helical oligopeptides. The helical chirality of the oligopeptides is controlled by a stereocentre remote from the metal. We show that when a mixture of chiral and achiral peptide ligands is used, both the chirality of the metal centre and that of the achiral oligopeptide helices are significantly amplified. The amplification mechanism relies on several steps of chirality induction, first from a single chiral peptide to the helicity of an oligopeptide through the induction of propeller chirality at the metal centre, then on to induction of helical chirality in an achiral oligopeptide.
Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Chikusa-ku, Nagoya 464-8603, Japan.
Naoki
N
Ousaka
Yuki
Y
Takeyama
Hiroki
H
Iida
Eiji
E
Yashima
D015082:2,2'-Dipyridyl / Q000737:chemistry; D002942:Circular Dichroism; D056831:Coordination Complexes / Q000737:chemistry; D018360:Crystallography, X-Ray; D050091:Dendrimers / Q000737:chemistry*; D008024:Ligands; D008670:Metals / Q000737:chemistry*; D008968:Molecular Conformation; D009842:Oligopeptides / Q000737:chemistry*; D017433:Protein Structure, Secondary; D013237:Stereoisomerism
D056831:Coordination Complexes; D050091:Dendrimers; D008024:Ligands; D008670:Metals; D009842:Oligopeptides; D015082:2,2'-Dipyridyl