Developing asymmetric iron and ruthenium-based cyclone complexes; complex factors influence the asymmetric induction in the transfer hydrogenation of ketones.
The preparation of a range of asymmetric iron and ruthenium-cyclone complexes, and their application to the asymmetric reduction of a ketone, are described. The enantioselectivity of ketone reduction is influenced by a single chiral centre in the catalyst, as well as by the planar chirality in the catalyst. This represents the first example of asymmetric ketone reduction using an iron cyclone catalyst.
Department of Chemistry, The University of Warwick, Coventry, UK CV4 7AL.
Jonathan P
JP
Hopewell
José E D
JE
Martins
Tarn C
TC
Johnson
Jamie
J
Godfrey
Martin
M
Wills