Sunitinib induced pyoderma gangrenosum-like ulcerations.
Pyoderma gangrenosum is a non-infectious neutro?philic skin disease commonly associated with underlying systemic diseases. Histopathological and laboratory diagnostics are unspecific in the majority of the cases and the diagnosis is made in accordance with the clinical picture. Here, we report the case of a 69-year old man with progredient pyoderma gangrenosum-like ulcerations under treatment with sunitinib due to hepatocellular carcinoma. A conventional ulcer therapy did not lead to a regression of the lesions. Solely cessation of sunitinib therapy resulted in an improvement of the ulcerations. Sunitinib is a multikinase inhibitor that targets the PDGF-α- and ?β-, VEGF-1-3-, KIT-, FLT3-, CSF-1- and RET-receptor, thereby impairing tumour proliferation, pathological angiogenesis and metastasation. Here, we demonstrate that pyoderma gangrenosum-like ulcers may represent a serious side effect of sunitinib-based anti-cancer treatment.
Universitätsklinikum Düsseldorf, Heinrich Heine Universität, Duesseldorf, Germany.
S
S
Akanay-Diesel
N P
NP
Hoff
S
S
Kürle
J
J
Haes
A
A
Erhardt
D
D
Häussinger
K-W
KW
Schulte
Edwin
E
Bölke
C
C
Matuschek
W
W
Budach
P A
PA
Gerber
B
B
Homey
D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D004890:Erythema / Q000139:chemically induced / Q000150:complications; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced / Q000150:complications; D017496:Hypopigmentation / Q000139:chemically induced / Q000150:complications; D007211:Indoles / Q000009:adverse effects*; D008297:Male; D054843:Negative-Pressure Wound Therapy; D017511:Pyoderma Gangrenosum / Q000139:chemically induced* / Q000150:complications* / Q000628:therapy; D011758:Pyrroles / Q000009:adverse effects*; D000077210:Sunitinib; D014456:Ulcer / Q000139:chemically induced* / Q000150:complications* / Q000628:therapy
D000970:Antineoplastic Agents; D007211:Indoles; D011758:Pyrroles; D000077210:Sunitinib