3,4-methylenedioxypyrovalerone (MDPV): chemistry, pharmacology and toxicology of a new designer drug of abuse marketed online.
The illicit marketplace of substances of abuse continually offers for sale legal alternatives to controlled drugs to a large public. In recent years, a new group of designer drugs, the synthetic cathinones, has emerged as a new trend, particularly among young people. The 3,4-methylenedioxypyrovalerone (MDPV), one of this synthetic compounds, caused an international alert for its cardiovascular and neurological toxicity. This substance, sold as bath salts, has caused many serious intoxications and some deaths in several countries. The aim of this paper is summarise the clinical, pharmacological and toxicological information about this new designer drug.
Department of Addiction, ASL CN2, Viale Coppino 46, 12051, Alba (CN), Italy. coppolamail@alice.it
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Coppola
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Mondola
D000470:Alkaloids / Q000138:chemical synthesis; D052117:Benzodioxoles / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D015198:Designer Drugs / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D004335:Drug and Narcotic Control; D014943:Global Health; D006801:Humans; D013287:Illicit Drugs / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D020407:Internet; D040541:Marketing / Q000379:methods; D011619:Psychotropic Drugs / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D011759:Pyrrolidines / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D000094982:Synthetic Cathinone
D000470:Alkaloids; D052117:Benzodioxoles; D015198:Designer Drugs; D013287:Illicit Drugs; D011619:Psychotropic Drugs; D011759:Pyrrolidines; C023665:cathinone; D000094982:Synthetic Cathinone