Outcome of Chlamydia pneumoniae associated acute ischemic stroke in elderly patients: a case-control study.
BACKGROUND
Limited data exists about the role of Chlamydia pneumoniae elderly patients with acute ischemic stroke.


OBJECTIVE
To study the role of C. pneumoniae in elderly patients (age more than 65 years) with acute ischemic stroke and its impact on stroke out come.


METHODS
We recruited 100 elderly patients with acute ischemic stroke and 100 age and sex matched controls over a period of 2 years. IgG and IgA anti C. pneumoniae antibodies were measured by microimmunofluorescence technique in patients and controls. Good outcome was defined as a Modified Rankin score (mRS) of ≤2.


RESULTS
We found C. pneumoniae antibodies in 35% stroke patients and in 18% control subjects (p=0.01). Good out come at 90 days follow up was found in 20/35(57.1%) seropositive stroke patients compared to 37/65(56.9%) seronegative stroke patients (p=0.9).


CONCLUSIONS
C. pneumoniae antibody positivity was independently associated with ischemic stroke in elderly patients and its presence does not alter the stroke outcome.
Department of Clinical Research, Yashoda Hospital, Somajiguda, Hyderabad 500082, India.
V C S Srinivasarao
VC
Bandaru
Demudu Babu
DB
Boddu
K Rukmini
KR
Mridula
B
B
Akhila
Suvarna
S
Alladi
V
V
Laxmi
Rammohan
R
Pathapati
M
M
Neeraja
Subhash
S
Kaul
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D000907:Antibodies, Bacterial / Q000032:analysis; D002545:Brain Ischemia / Q000209:etiology* / Q000628:therapy; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D059345:Cerebral Small Vessel Diseases / Q000382:microbiology; D002690:Chlamydia Infections / Q000150:complications* / Q000382:microbiology / Q000628:therapy; D016993:Chlamydophila pneumoniae; D005260:Female; D005455:Fluorescent Antibody Technique; D005500:Follow-Up Studies; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011446:Prospective Studies; D012307:Risk Factors; D020521:Stroke / Q000209:etiology* / Q000628:therapy; D016896:Treatment Outcome
D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D002097:C-Reactive Protein