Susceptibility to winter vomiting disease: a sweet matter.
Norovirus, the cause of winter vomiting disease, has emerged in recent years to be a major cause of sporadic and epidemic gastroenteritis worldwide. The virus has been estimated to cause >200,000 deaths each year in developing countries. Although the virus is highly contagious, volunteer and field studies have shown that a subset of individuals appears resistant to infections. A single nucleotide mutation (G428A) in the fucosyltransferase gene (FUT2) on chromosome 19 provides strong protection from infection in 20% of the white population. Histo-blood group ABO(H) antigens with terminal fucose are believed to function as receptors for human norovirus in the gastrointestinal tract, but also negatively charged potential receptors have been identified. Norovirus infection is a unique example where a single nucleotide mutation in a fucosyltransferase gene plays a crucial role in susceptibility to one of the most common viral diseases. This review discusses the role of host genetics and carbohydrate structures in susceptibility to winter vomiting disease.
Dept of Clinical Chemistry and Transfusion Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Gustaf E
GE
Rydell
Elin
E
Kindberg
Göran
G
Larson
Lennart
L
Svensson
D001789:Blood Group Antigens / Q000737:chemistry / Q000378:metabolism*; D017250:Caliciviridae Infections / Q000453:epidemiology / Q000235:genetics* / Q000821:virology; D005647:Fucosyltransferases / Q000235:genetics*; D005759:Gastroenteritis / Q000453:epidemiology / Q000235:genetics* / Q000821:virology; D020022:Genetic Predisposition to Disease; D006801:Humans; D029322:Norovirus / Q000472:pathogenicity*; D020641:Polymorphism, Single Nucleotide; D011991:Receptors, Virus / Q000737:chemistry / Q000378:metabolism*; D012621:Seasons; D014839:Vomiting / Q000453:epidemiology / Q000209:etiology / Q000821:virology; D000097631:Galactoside 2-alpha-L-fucosyltransferase
D001789:Blood Group Antigens; D005647:Fucosyltransferases; D011991:Receptors, Virus; D000097631:Galactoside 2-alpha-L-fucosyltransferase