Pharmacokinetics of lisdexamfetamine dimesylate after targeted gastrointestinal release or oral administration in healthy adults.
The purpose of this work was to assess the pharmacokinetics and safety of lisdexamfetamine dimesylate (LDX) delivered and released regionally in the gastrointestinal (GI) tract. In this open-label, randomized, crossover study, oral capsules and InteliSite delivery capsules containing LDX (50 mg) with radioactive marker were delivered to the proximal small bowel (PSB), distal SB (DSB), and ascending colon (AC) during separate periods. Gamma scintigraphy evaluated regional delivery and GI transit. LDX and d-amphetamine in blood were measured postdose (≤72 h). Treatment-emergent adverse events (TEAEs) were assessed. Healthy males (n = 18; 18-48 years) were enrolled. Mean (S.D.) maximal plasma concentration (C(max)) was 37.6 (4.54), 40.5 (4.95), 38.7 (6.46), and 25.7 (9.07) ng/ml; area under the concentration-time curve to the last measurable time point was 719.1 (157.05), 771.2 (152.88), 752.4 (163.38), and 574.3 (220.65) ng · h · ml⁻¹, respectively, for d-amphetamine after oral, PSB, DSB, and AC delivery of LDX. Median time to C(max) was 5, 4, 5, and 8 h, respectively. Most TEAEs were mild to moderate. No clinically meaningful changes were observed (laboratory, physical examination, or electrocardiogram). LDX oral administration or targeted delivery to small intestine had similar d-amphetamine systemic exposure, indicating good absorption, and had reduced absorption after colonic delivery. The safety profile was consistent with other LDX studies.
Clinical Pharmacology, Shire Development Inc., Wayne, Pennsylvania, USA. jaermer@shire.com
James C
JC
Ermer
Mary B
MB
Haffey
Walter J
WJ
Doll
Patrick
P
Martin
Erik P
EP
Sandefer
Kerry
K
Dennis
Mary
M
Corcoran
Laura
L
Trespidi
Richard C
RC
Page
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001711:Biotransformation; D000697:Central Nervous System Stimulants / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics*; D044682:Colon, Ascending / Q000378:metabolism; D018592:Cross-Over Studies; D003913:Dextroamphetamine / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems / Q000009:adverse effects; D004386:Duodenum / Q000378:metabolism; D004582:Electronics, Medical / Q000379:methods; D005772:Gastrointestinal Transit; D006207:Half-Life; D006801:Humans; D007082:Ileum / Q000378:metabolism; D007408:Intestinal Absorption; D000069478:Lisdexamfetamine Dimesylate; D008297:Male; D008875:Middle Aged; D011355:Prodrugs / Q000008:administration & dosage* / Q000032:analysis / Q000493:pharmacokinetics*; D013678:Technology, Pharmaceutical; D055815:Young Adult
D000697:Central Nervous System Stimulants; D011355:Prodrugs; D000069478:Lisdexamfetamine Dimesylate; D003913:Dextroamphetamine