Women with fibromyalgia have lower levels of calcium, magnesium, iron and manganese in hair mineral analysis.
Little is known about hair mineral status in fibromyalgia patients. This study evaluated the characteristics of hair minerals in female patients with fibromyalgia compared with a healthy reference group. Forty-four female patients diagnosed with fibromyalgia according to the American College of Rheumatology criteria were enrolled as the case group. Age and body mass index-matched data were obtained from 122 control subjects enrolled during visit for a regular health check-up. Hair minerals were analyzed and compared between the two groups. The mean age was 43.7 yr. General characteristics were not different between the two groups. Fibromyalgia patients showed a significantly lower level of calcium (775 µg/g vs 1,093 µg/g), magnesium (52 µg/g vs 72 µg/g), iron (5.9 µg/g vs 7.1 µg/g), copper (28.3 µg/g vs 40.2 µg/g) and manganese (140 ng/g vs 190 ng/g). Calcium, magnesium, iron, and manganese were loaded in the same factor using factor analysis; the mean of this factor was significantly lower in fibromyalgia group in multivariate analysis with adjustment for potential confounders. In conclusion, the concentrations of calcium, magnesium, iron, and manganese in the hair of female patients with fibromyalgia are lower than of controls, even after adjustment of potential confounders.
Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon, Korea.
Young-Sang
YS
Kim
Kwang-Min
KM
Kim
Duck-Joo
DJ
Lee
Bom-Taeck
BT
Kim
Sat-Byul
SB
Park
Doo-Yeoun
DY
Cho
Chang-Hee
CH
Suh
Hyoun-Ah
HA
Kim
Rae-Woong
RW
Park
Nam-Seok
NS
Joo
D000328:Adult; D001827:Body Height; D015992:Body Mass Index; D002118:Calcium / Q000032:analysis; D005260:Female; D005356:Fibromyalgia / Q000378:metabolism*; D006197:Hair / Q000737:chemistry*; D006801:Humans; D007501:Iron / Q000032:analysis; D008274:Magnesium / Q000032:analysis; D008345:Manganese / Q000032:analysis; D008670:Metals / Q000032:analysis*; D008875:Middle Aged
D008670:Metals; D008345:Manganese; D007501:Iron; D008274:Magnesium; D002118:Calcium