Monitoring tobacco-specific N-nitrosamines and nicotine in novel Marlboro and Camel smokeless tobacco products: findings from Round 1 of the New Product Watch.
BACKGROUND
Information on chemical composition of the new oral "spitless" smokeless tobacco products is scarce, and it is not clear whether there is some variability as a function of purchase place or time due to either unintended or intended manufacturing variations or other conditions.


METHODS
We analyzed tobacco-specific N-nitrosamines (TSNA) and nicotine in Marlboro Snus, Camel Snus, and dissolvable Camel products Orbs, Sticks, and Strips that were purchased in various regions of the country during the summer of 2010.


RESULTS
A total of 117 samples were received from different states representing six regions of the country. Levels of unprotonated nicotine in Marlboro Snus and Camel Snus varied significantly by regions, with the differences between the highest and the lowest average regional levels being relatively small in Marlboro Snus (∼1.3-fold) and large in Camel Snus (∼3-fold). Some regional variations in TSNA levels were also observed. Overall, Camel Snus had significantly higher TSNA levels than Marlboro Snus, and Camel Strips had the lowest TSNA levels among all novel products analyzed here. The amount of unprotonated nicotine in the dissolvable Camel products was comparable to the levels found in Marlboro Snus.


CONCLUSIONS
Our study demonstrates some regional variations in the levels of nicotine and TSNA in Marlboro and Camel novel smokeless tobacco products. Continued monitoring of this category of products is needed as the existing products are being test marketed and modified, and new products are being introduced. This information is particularly important given its relevance to Food and Drug Administration regulation of tobacco products.
Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA. stepa011@umn.edu
Irina
I
Stepanov
Lois
L
Biener
Aleksandar
A
Knezevich
Amy L
AL
Nyman
Robin
R
Bliss
Joni
J
Jensen
Stephen S
SS
Hecht
Dorothy K
DK
Hatsukami
D009538:Nicotine / Q000032:analysis*; D009602:Nitrosamines / Q000032:analysis*; D014030:Tobacco, Smokeless / Q000737:chemistry*; D014481:United States
D009602:Nitrosamines; D009538:Nicotine