Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: evidence for assortative mating.
Triplet repeats contribute to normal variation in behavioral traits and when expanded, cause brain disorders. While Huntington's Disease is known to be caused by a CAG triplet repeat in the gene Huntingtin, the effect of CAG repeats on brain function below disease threshold has not been studied. The current study shows a significant correlation between the CAG repeat length of the maternal and paternal allele in the Huntingtin gene among healthy subjects, suggesting assortative mating.
Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA. peggy-nopoulos@uiowa.edu
Peg
P
Nopoulos
Eric A
EA
Epping
Tom
T
Wassink
Bradley L
BL
Schlaggar
Joel
J
Perlmutter
D000293:Adolescent; D000483:Alleles; D016022:Case-Control Studies; D002648:Child; D005260:Female; D018628:Gene Dosage / Q000235:genetics*; D014644:Genetic Variation; D006801:Humans; D000071058:Huntingtin Protein; D006816:Huntington Disease / Q000235:genetics*; D008297:Male; D008957:Models, Genetic; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D012016:Reference Values; D012641:Selection, Genetic; D018911:Trinucleotide Repeats
C086055:HTT protein, human; D000071058:Huntingtin Protein; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins