Enhancement of metabolites productivity of Penicillium pinophilum FKI-5653, by co-culture with Trichoderma harzianum FKI-5655.
In the course of discovering new metabolites from co-culture of Penicillium pinophilum FKI-5653 and Trichoderma harzianum FKI-5655, a new compound, designated secopenicillide C, and four known compounds, penicillide, MC-141, pestalasin A and stromemycin were isolated. The production of these compounds, except pestalasin A, was enhanced in co-culture to be two to six times higher than in pure culture of Penicillium pinophilum FKI-5653, which was the producer of these compounds.
Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, Japan.
Kenichi
K
Nonaka
Tadahide
T
Abe
Masato
M
Iwatsuki
Mihoko
M
Mori
Tsuyoshi
T
Yamamoto
Kazuro
K
Shiomi
Satoshi
S
Omura
Rokuro
R
Masuma
D001483:Base Sequence; D018920:Coculture Techniques; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D008828:Microbiological Techniques / Q000379:methods; D008969:Molecular Sequence Data; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000235:genetics / Q000378:metabolism* / Q000648:ultrastructure; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D021241:Spectrometry, Mass, Electrospray Ionization; D014242:Trichoderma / Q000235:genetics / Q000378:metabolism* / Q000648:ultrastructure
D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer