Antibiotic allergy.
Antibiotics are commonly injected during the perioperative period and are responsible of 15 percent of the anaphylactic reactions. Anaphylaxis triggered by antibiotics primarily involves penicillin and cephalosporin. The management of patients with histories of allergic reactions to antibiotics is a common situation in clinical practice. The confirmation or invalidation of the allergic nature of the reported reaction is not based on in vitro tests, but on a rigorous allergological work-up based on detailed analysis of clinical history, skin tests and drug provocation test. Considering a possible cross-reactivity between penicillins, once an immediate penicillin allergy has been diagnosed, skin testing with the alternative molecule (cephalosporin, carbapenem, aztreonam) is mandatory and, if negative, the relevant drug should be given in an appropriate setting at increasing doses.
Department of Pediatrics, University of Pavia, Italy. sissi_del_78@hotmail.com
S
S
Caimmi
D
D
Caimmi
E
E
Lombardi
G
G
Crisafulli
F
F
Franceschini
G
G
Ricci
G L
GL
Marseglia
D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000737:chemistry / Q000145:classification; D003429:Cross Reactions; D003888:Desensitization, Immunologic; D004342:Drug Hypersensitivity / Q000145:classification / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D059035:Perioperative Period; D012882:Skin Tests
D000900:Anti-Bacterial Agents