[Study on pharmacokinetics of ferulic acid loaded liposome-in-chitosan-microspheres in rats].
In this paper, the pharmacokinetics of ferulic acid loaded liposome-in-chitosan-microspheres was investigated. Eighteen Sprague-Dawley rats were divided into 3 groups randomly. Each group was administered orally of ferulic acid, ferulic acid loaded chitosan microspheres and ferulic acid loaded liposome-in-chitosan-microspheres, respectively. Then blood samples were obtained from fossa orbitalis at different time points. The concentration of ferulic acid in blood was analyzed by a HPLC method using coumarin as internal standard. The data were analyzed by DAS program. The t(max), MRT and t(1/2beta) of liposome-in-chitosan-microspheres were 2.500, 7.487 and 7.818 h, respectively, which were much longer than crude drug and chitosan microspheres. This results demonstrated that liposome-in-chitosan-microspheres had better sus-tained-releasing property. The AUC of liposome-in-chitosan-microspheres was 6.08 times higher than crude drug and 1.21 times higher than chitosan microspheres, which verified that liposome-in-chitosan-microspheres could enhance oral absorption.
College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
Jifen
J
Zhang
Huanhuan
H
Yuan
Lin
L
Du
Qin
Q
Tnag
Xiaoyu
X
Xu
D000042:Absorption; D000284:Administration, Oral; D000818:Animals; D000925:Anticoagulants / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D001672:Biocompatible Materials; D048271:Chitosan; D003373:Coumaric Acids / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations; D008081:Liposomes; D008297:Male; D008863:Microspheres; D009915:Orbit / Q000098:blood supply / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D000925:Anticoagulants; D001672:Biocompatible Materials; D003373:Coumaric Acids; D003692:Delayed-Action Preparations; D008081:Liposomes; D048271:Chitosan; C004999:ferulic acid