HSP22 and its role in human neurological disease.
HSP22 (heat shock protein 22), belonging to the superfamily of small heat shock proteins, which has a molecular mass of 21.6 KD and is able to exist in the form of monomer, has multiple functions including molecular chaperones, apoptosis and anti-apoptosis, lifespan extension, antioxidation and so on. In recent years, studies show that HSP22 plays a crucial role in many neurological diseases, such as hereditary nerve endings disease, Alzheimer disease and Charco-Marie-Tooth. This review explores the progress in HSP22 and its involvement in human neurological disease.
Department of Neurology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Xiaomei
X
Guan
Chao
C
Tu
Mengjun
M
Li
Zhiping
Z
Hu
D051547:Heme Oxygenase-1 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009422:Nervous System Diseases / Q000235:genetics / Q000378:metabolism*
C496541:HMOX1 protein, human; D051547:Heme Oxygenase-1