Single-walled carbon nanohorns as drug carriers: adsorption of prednisolone and anti-inflammatory effects on arthritis.
Prednisolone (PSL), an anti-inflammatory glucocorticoid drug, was adsorbed on oxidized single-walled carbon nanohorns (oxSWNHs) in ethanol-water solvent. The quantity of adsorbed PSL on the oxSWNHs was 0.35-0.54 g/g  depending on the sizes and numbers of holes on the oxSWNHs. PSL was adsorbed on both the outside and the inside of the oxSWNHs, and released quickly in a couple of hours and slowly within about one day from the respective places. The released quantity in culture medium strongly depended on the concentration of the PSL-oxSWNH complexes, suggesting that PSL adsorbing on oxSWNHs and PSL in the culture medium were in concentration equilibrium. The local injection of PSL-oxSWNHs into the tarsal joint of rats with collagen-induced arthritis (CIA) slightly retarded the progression of the arthritis compared with controls. By histological analysis of the ankle joint, the anti-inflammatory effect of PSL-oxSWNHs was also observed.
National Institute of Advanced Industrial Science and Technology, 1-1-1 Higashi, Tsukuba 305-8565, Japan. ma-ki-nakamura@aist.go.jp
Maki
M
Nakamura
Yoshio
Y
Tahara
Yuzuru
Y
Ikehara
Tatsuya
T
Murakami
Kunihiro
K
Tsuchida
Sumio
S
Iijima
Iwao
I
Waga
Masako
M
Yudasaka
D000327:Adsorption; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D001169:Arthritis, Experimental / Q000188:drug therapy*; D004337:Drug Carriers / Q000737:chemistry*; D005260:Female; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D011239:Prednisolone / Q000008:administration & dosage* / Q000627:therapeutic use*; D051381:Rats
D000893:Anti-Inflammatory Agents; D004337:Drug Carriers; D037742:Nanotubes, Carbon; D011239:Prednisolone