Role of Tc-Sulesomab Immunoscintigraphy in the Management of Infection following Deep Brain Stimulation Surgery.
Infection constitutes a serious adverse event in patients submitted to deep brain stimulation, often leading to removal of the device. We set to evaluate the potential role of immunoscintigraphy with (99m)Tc-labelled antigranulocyte antibody fragments ((99m)Tc-sulesomab) in the management of infection following DBS. (99m)Tc-sulesomab immunoscintigraphy seems to correlate well with the presence and extent of infection, thus contributing to differentiate between patients who should remove the hardware entirely at presentation and those who could undergo a more conservative approach. Also, (99m)Tc-sulesomab immunoscintigraphy has a role in determining the most appropriate timing for reimplantation. Finally, we propose an algorithm for the management of infection following DBS surgery, based on the results of the (99m)Tc-sulesomab immunoscintigraphy.
Department of Neurology, Hospital de São João, Alameda Prof. Hernâni Monteiro, 4200 Porto, Portugal.
Raquel
R
Real
Paulo
P
Linhares
Hélder
H
Fernandes
Maria José
MJ
Rosas
Miguel F
MF
Gago
Jorge
J
Pereira
Rui
R
Vaz