[News on antithrombotic therapy and pregnancy].
OBJECTIVE
State of the art of antithrombotics and their use recommendations during pregnancy.


METHODS
A review


RESULTS
Aspirin and heparins remain the safest molecules during pregnancy, and oral anticoagulants are still used for mechanical valves. Heparinoids are the methods of choice in case of heparin-induced thrombopenia but other molecules could find their place: fondaparinux at first and possibly the direct thrombin inhibitors. Thrombolysis may be used in case of life-threatening incident. At present, the new oral forms can not be used during pregnancy


CONCLUSIONS
During pregnancy, all antithrombotics, except the oral forms, can be used, but the low molecular weight heparins replacing the unfractionated ones in the treatment and prevention of venous thromboembolism remain the treatment of choice.
Département d'Obstétrique et Gynécologie, CHU Saint-Étienne Hôpital Nord, Saint-Priest-en-Jarez, France. celine.chauleur@chu-st-etienne.fr
Céline
C
Chauleur
Jean-Christophe
JC
Gris
Pierre
P
Seffert
Patrick
P
Mismetti
D000328:Adult; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D015951:Factor Xa / Q000009:adverse effects; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005493:Folic Acid Antagonists / Q000009:adverse effects; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D011263:Pregnancy Trimester, Third / Q000502:physiology*; D013917:Thrombin / Q000037:antagonists & inhibitors; D015912:Thrombolytic Therapy; D054556:Venous Thromboembolism / Q000188:drug therapy; D014812:Vitamin K / Q000037:antagonists & inhibitors
D005343:Fibrinolytic Agents; D005493:Folic Acid Antagonists; D014812:Vitamin K; D006493:Heparin; D013917:Thrombin; D015951:Factor Xa; D001241:Aspirin