Plasma levels of stromal cell-derived factor-1 in patients with coronary artery disease: effect of clinical presentation and cardiovascular risk factors.
OBJECTIVE
To investigate the possible association of plasma levels of stromal cell-derived factor-1 (SDF-1; CXCL12) with clinical presentation of symptomatic coronary artery disease (CAD) and with cardiovascular risk factors.


METHODS
A cath lab cohort of 492 consecutive patients with symptomatic CAD were recruited. Blood for plasma-SDF-1 determination was taken at the time of heart catheterization before percutaneous coronary intervention.


RESULTS
Plasma-SDF-1 was significantly decreased in ST-elevation myocardial infarction (STEMI) compared to stable angina pectoris (SAP) or to non-ST-elevation myocardial infarction (NSTEMI) (SAP vs. NSTEMI vs. STEMI: [pg/ml]: mean ± SD: 2110 ± 562 vs. 2127 ± 467 vs. 1834 ± 377; P < 0.001) independent of cardiovascular therapy. A weak correlation was observed between cholesterol levels and plasma SDF-1 in the whole study population. Left ventricular function and diabetes mellitus associated with plasma SDF-1 levels in patients with NSTEMI, while among STEMI patients, those with hyperlipidemia presented with even further decreased SDF-1 levels.


CONCLUSIONS
Plasma SDF-1 is significantly decreased in patients with STEMI, a fact which may reflect the importance of SDF-1 regulation in patients with acute myocardial infarction.
Department of Cardiology, Centre of Internal Medicine III, Johann Wolfgang Goethe University Frankfurt am Main, Frankfurt, Germany. konstantinos.stellos@kgu.de
Konstantinos
K
Stellos
Madlen
M
Ruf
Kateryna
K
Sopova
Antonios
A
Kilias
Angela
A
Rahmann
Kimon
K
Stamatelopoulos
Rezo
R
Jorbenadze
Tobias
T
Geisler
Meinrad
M
Gawaz
Boris
B
Bigalke
D000704:Analysis of Variance; D060050:Angina, Stable / Q000097:blood* / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D015415:Biomarkers / Q000097:blood; D054377:Chemokine CXCL12 / Q000097:blood*; D016009:Chi-Square Distribution; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D015536:Down-Regulation; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000097:blood* / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors
D015415:Biomarkers; C515255:CXCL12 protein, human; D054377:Chemokine CXCL12