In vitro and in vivo fluorescent imaging of a monofunctional chelated platinum complex excitable using visible light.
The biological fluorescent distribution of a model antitumor monofunctional platinum(II) complex bearing a 7-nitro-2,1,3-benzoxadiazole fluorophore can be visualized in breast carcinoma MCF-7 cells, pulmonary carcinoma A549 cells, kidney epithelial 293T cells, and zebrafish larva.
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing, 210017,  People's Republic of China.
Shengde
S
Wu
Chengcheng
C
Zhu
Changli
C
Zhang
Zhen
Z
Yu
Weijiang
W
He
Yafeng
Y
He
Yizhi
Y
Li
Jing
J
Wang
Zijian
Z
Guo
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism*; D045744:Cell Line, Tumor; D002614:Chelating Agents / Q000737:chemistry*; D006801:Humans; D007814:Larva / Q000378:metabolism; D008027:Light; D057054:Molecular Imaging / Q000379:methods*; D009944:Organoplatinum Compounds / Q000737:chemistry* / Q000378:metabolism*; D010069:Oxadiazoles / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D015027:Zebrafish
C542965:7-nitrobenzoxadiazole; D000970:Antineoplastic Agents; D002614:Chelating Agents; D009944:Organoplatinum Compounds; D010069:Oxadiazoles