Hemangioma is associated with atopic disease.
OBJECTIVE
To determine if atopic disease is associated with infantile hemangioma.


METHODS
Case control study.


METHODS
State of Utah inpatient and outpatient records obtained from the Department of Health, Intermountain Healthcare medical records, and the University of Utah Health Care medical records using the Utah Population Database.


METHODS
Patients given an International Classification of Diseases, Ninth Revision diagnosis of hemangioma prior to age 5 years, from 1991 to 2009.


METHODS
Allergy, asthma, and eczema rates in the hemangioma cohort compared to randomly matched controls using logistic regression analysis.


RESULTS
The authors identified 2063 patients in the hemangioma group. The overall odds ratio of atopic disease in patients diagnosed with hemangioma was 1.67 compared to the control group (P < .0001). In the hemangioma cohort, the authors found a 36% increased risk of allergies (P < .0001), 67% increased risk of asthma (P < 4e-12), and 82% increased risk of eczema (P < 2e-16).


CONCLUSIONS
This study indicates that allergy, asthma, and eczema are positively associated with hemangioma. Eczema was most strongly associated with hemangioma, with a nearly 2-fold increased risk. Understanding the relationship between atopic disease and infantile hemangioma may elucidate the pathophysiology of each and ultimately lead to better treatment options.
Division of Otolaryngology, Department of Surgery, University of Utah, Salt Lake City, Utah, USA.
J Fredrik
JF
Grimmer
Marc S
MS
Williams
Richard
R
Pimentel
Geraldine
G
Mineau
Grant M
GM
Wood
Pinar
P
Bayrak-Toydemir
David A
DA
Stevenson
D001249:Asthma / Q000453:epidemiology / Q000209:etiology*; D016022:Case-Control Studies; D002675:Child, Preschool; D004485:Eczema / Q000453:epidemiology / Q000209:etiology*; D006258:Head and Neck Neoplasms / Q000150:complications*; D006391:Hemangioma / Q000150:complications*; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology / Q000209:etiology*; D007223:Infant