Breast cancer affects both the hippocampus volume and the episodic autobiographical memory retrieval.
BACKGROUND
Neuroimaging studies show the hippocampus is a crucial node in the neural network supporting episodic autobiographical memory retrieval. Stress-related psychiatric disorders, namely Major Depression and Post Traumatic Stress Disorder (PTSD), are related to reduced hippocampus volume. However, this is not the case for remitted breast cancer patients with co-morbid stress-related psychiatric disorders. This exception may be due to the fact that, consequently to the cancer experience as such, this population might already be characterized by a reduced hippocampus with an episodic autobiographical memory deficit.


METHODS
We scanned, with a 3T Siemens TRIO, 16 patients who had lived through a "standard experience of breast cancer" (breast cancer and a standard treatment in remission since 18 month) in the absence of any associated stress-related psychiatric or neurological disorder and 21 matched controls. We then assessed their episodic autobiographical memory retrieval ability.


RESULTS
Remitted breast cancer patients had both a significantly smaller hippocampus and a significant deficit in episodic autobiographical memory retrieval. The hippocampus atrophy was characterized by a smaller posterior hippocampus. The posterior hippocampus volume was intimately related to the ability to retrieve negative memories and to the past experience of breast cancer or not.


CONCLUSIONS
These results provide two main findings: (1) we identify a new population with a specific reduction in posterior hippocampus volume that is independent of any psychiatric or neurological pathology; (2) we show the intimate relation of the posterior hippocampus to the ability to retrieve episodic autobiographical memories. These are significant findings as it is the first demonstration that indicates considerable long-term effects of living through the experience of breast cancer and shows very specific hippocampal atrophy with a functional deficit without any presence of psychiatric pathology.
CNRS USR 3246, CR-ICM, Pitié-Salpêtrière Hospital, Paris, France. loretxu@alternatiba.org
Loretxu
L
Bergouignan
Jean Pierre
JP
Lefranc
Marie
M
Chupin
Nastassja
N
Morel
Jean Philippe
JP
Spano
Philippe
P
Fossati
D000293:Adolescent; D000328:Adult; D001943:Breast Neoplasms / Q000150:complications / Q000473:pathology* / Q000503:physiopathology* / Q000628:therapy; D005260:Female; D059907:Functional Neuroimaging; D006624:Hippocampus / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D061212:Memory, Episodic; D008875:Middle Aged; D009929:Organ Size; D055815:Young Adult