Complementary screening techniques yielded fragments that inhibit the phosphatase activity of soluble epoxide hydrolase.
Institute of Pharmaceutical Chemistry, LiFF/OSF/ZAFES, Goethe University, Max-von-Laue Str. 9, 60438 Frankfurt/M, Germany.
Steffen
S
Hahn
Janosch
J
Achenbach
Estella
E
Buscató
Franca-Maria
FM
Klingler
Mirjam
M
Schroeder
Karin
K
Meirer
Martina
M
Hieke
Jan
J
Heering
Eduardo
E
Barbosa-Sicard
Frank
F
Loehr
Ingrid
I
Fleming
Volker
V
Doetsch
Manfred
M
Schubert-Zsilavecz
Dieter
D
Steinhilber
Ewgenij
E
Proschak
D003198:Computer Simulation; D004353:Drug Evaluation, Preclinical; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D004851:Epoxide Hydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005456:Fluorescent Dyes / Q000737:chemistry; D007700:Kinetics; D017434:Protein Structure, Tertiary; D013379:Substrate Specificity
D004791:Enzyme Inhibitors; D005456:Fluorescent Dyes; D004851:Epoxide Hydrolases