Improvement of endothelial function in parallel with the amelioration of dry cough and dyspnea due to interstitial pneumonia by intravenous cyclophosphamide pulse therapy in patients with systemic sclerosis: a preliminary report of two cases.
Intravenous cyclophosphamide pulse therapy (IVCY) exerts its efficacy against interstitial lung disease (ILD) associated with systemic sclerosis (SSc) by restoring vascular injuries as well as aberrant immune activation. We recently experienced two patients with SSc-ILD in whom the values of brachial flow-mediated dilation (FMD) reflected the efficacy of IVCY. We herein report the details of these cases and discuss the potential of FMD to predict and evaluate the effect of IVCY on SSc-ILD.
Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Takehiro
T
Takahashi
Yoshihide
Y
Asano
Eisuke
E
Amiya
Masaru
M
Hatano
Zenshiro
Z
Tamaki
Atsuko
A
Ozeki
Aya
A
Watanabe
Shuichi
S
Kawarasaki
Tomoko
T
Nakao
Takashi
T
Taniguchi
Yohei
Y
Ichimura
Tetsuo
T
Toyama
Masafumi
M
Watanabe
Yasunobu
Y
Hirata
Ryozo
R
Nagai
Shinichi
S
Sato
D000368:Aged; D003371:Cough / Q000188:drug therapy* / Q000503:physiopathology; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use*; D004417:Dyspnea / Q000188:drug therapy* / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007275:Injections, Intravenous; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D008875:Middle Aged; D020551:Pulse Therapy, Drug; D012595:Scleroderma, Systemic / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D012867:Skin / Q000098:blood supply / Q000473:pathology; D016896:Treatment Outcome; D014664:Vasodilation / Q000187:drug effects
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide