Bone Morphogenetic Protein functions as a context-dependent angiogenic cue in vertebrates.
Bone Morphogenetic Protein (BMP) signaling has been implicated in diverse biological processes. Although how BMP signaling regulates behaviors of endothelial cells during angiogenesis are not fully understood, increasing evidence indicate functions of BMP signaling components are essential in developmental and pathological angiogenesis. Here we review recent advances in delineating the functions of BMP signaling during angiogenesis. In addition, we discuss downstream pathways that transduce BMP signaling in endothelial cells, and factors that modulate BMP signaling response in endothelial cells. Finally, we provide recent insight on how BMP signaling functions as a context dependent angiogenic cue.
McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
David M
DM
Wiley
Suk-Won
SW
Jin
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000378:metabolism*; D002454:Cell Differentiation / Q000502:physiology; D042783:Endothelial Cells / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D009024:Morphogenesis; D018919:Neovascularization, Physiologic / Q000502:physiology*; D015398:Signal Transduction; D014714:Vertebrates / Q000378:metabolism*
D019485:Bone Morphogenetic Proteins