Trunk weighted obesity, cholesterol levels and low grade inflammation are main determinants for enhanced thrombin generation.
OBJECTIVE
Endogenous thrombin generation (ETP) may be critically involved in obesity associated thromboembolism.


METHODS
Three hundred and one participants of the STyrian Juvenile OBesity (STYJOBS)/Early DEteCTion of Atherosclerosis (EDECTA) study cohort (age, 16-58years) were analysed. ETP was measured by the new CE-IVD marked Siemens-Innovance(®) ETP test on a BCS-XP analyser, and correlated to clinical findings and extended lipometry-based anthropometric data, biomarkers, and coagulation parameters.


RESULTS
In the overweight/obese study group, ETP and fibrinogen levels were significantly higher compared to controls (p<0.001). In a multiple stepwise regression including all subjects, subcutaneous adipose tissue thickness of upper back, cholesterol and ultrasensitive C-reactive protein were the best predictors for ETP.


CONCLUSIONS
Trunk weighted obesity together with low grade inflammation and hypercholesterolemia enhance thrombin generation.
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria.
Florian
F
Prüller
Reinhard B
RB
Raggam
Verena
V
Posch
Gunter
G
Almer
Martie
M
Truschnig-Wilders
Renate
R
Horejsi
Reinhard
R
Möller
Daniel
D
Weghuber
Rottraut
R
Ille
Wolfgang
W
Schnedl
Harald
H
Mangge
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001317:Austria; D015415:Biomarkers / Q000097:blood; D001777:Blood Coagulation; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood*; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000150:complications*; D007249:Inflammation / Q000097:blood / Q000150:complications*; D018836:Inflammation Mediators / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000473:pathology; D011446:Prospective Studies; D012044:Regression Analysis; D018570:Risk Assessment; D012307:Risk Factors; D050151:Subcutaneous Fat / Q000473:pathology; D013917:Thrombin / Q000032:analysis*; D013923:Thromboembolism / Q000097:blood / Q000209:etiology*; D055815:Young Adult
D015415:Biomarkers; D018836:Inflammation Mediators; D005340:Fibrinogen; D002097:C-Reactive Protein; D002784:Cholesterol; D013917:Thrombin