Domino reactions for the synthesis of various α-substituted nitro alkenes.
Efficient one-pot methods for the synthesis of variously functionalised conjugated nitro alkenes have been reported. Despite the utility in different fields of these compounds, only a few multi-step syntheses have been reported in the literature, giving the target compounds in low overall yields. α-Nitro acrylates or cinnamates, α-nitro α,β-unsaturated ketones and, most importantly, aromatic and heteroaromatic (E)- 2-nitro allylic alcohols, compounds characterised by a well-known anticancer activity, were obtained in high yields and high diastereomeric purity by a domino condensation-dehydration process.
Dipartimento di Chimica, Università degli Studi di Roma La Sapienza, P.le Aldo Moro 5, I-00185, Roma, Italy. stefania.fioravanti@uniroma1.it
Stefania
S
Fioravanti
Lucio
L
Pellacani
Maria Cecilia
MC
Vergari
D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D009574:Nitro Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
D000475:Alkenes; D009574:Nitro Compounds