Mitochondrial dysfunction and Down's syndrome: is there a role for coenzyme Q(10) ?
Structural changes and abnormal function of mitochondria have been documented in Down's syndrome (DS) cells, patients, and animal models. DS cells in culture exhibit a wide array of functional mitochondrial abnormalities including reduced mitochondrial membrane potential, reduced ATP production, and decreased oxido-reductase activity. New research has also brought to central stage the prominent role of oxidative stress in this condition. This review focuses on recent advances in the field with a particular emphasis on novel translational approaches involving the utilization of coenzyme Q(10)  (CoQ(10) ) to treat a variety of clinical phenotypes associated with DS that are linked to increased oxidative stress and energy deficits. CoQ(10)  has already provided promising results in several different conditions associated with altered energy metabolism and oxidative stress in the CNS. Two studies conducted in Ancona investigated the effect of CoQ(10)  treatment on DNA damage in DS patients. Although the effect of CoQ(10)  was evidenced only at single cell level, the treatment affected the distribution of cells according to their content in oxidized bases. In fact, it produced a strong negative correlation linking cellular CoQ(10)  content and the amount of oxidized purines. Results suggest that the effect of CoQ(10)  treatment in DS not only reflects antioxidant efficacy, but likely modulates DNA repair mechanisms.
Department of Biochemistry, Biology and Genetics, Polytechnic University of the Marche, Ancona, Italy. luca.tiano@unicam.it
Luca
L
Tiano
Jorge
J
Busciglio
D000818:Animals; D004260:DNA Repair / Q000187:drug effects; D004314:Down Syndrome / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D016166:Free Radical Scavengers / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D018384:Oxidative Stress; D016032:Randomized Controlled Trials as Topic; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use
D016166:Free Radical Scavengers; D014451:Ubiquinone; C024989:coenzyme Q10