Widespread cerebral cortical mineralization in Wilson's disease detected by susceptibility-weighted imaging.
Signal abnormalities of cortical gray matter, compared with the deep nuclear structures, have received less attention in Wilson's disease (WD). They nearly always accompanied white matter signal change, and commonly are associated with epilepsy and psychiatric features. We report herein two cases diagnosed as WD who, in addition to characteristic deep nuclear lesions on MR imaging, had widespread cerebral cortical paramagnetic signals dramatically detected by susceptibility-weighted imaging. T2-weighted MR images did not show any cortico-subcortical hyperintense lesions. To our knowledge, these findings have not been described before and may help to further characterize the disease.
Department of Neurology, Pusan National University, Yangsan Hospital, Research Institute for Convergence of Biomedical Science and Technology, Yangsan, Republic of Korea. jhlee.neuro@pusan.ac.kr
Jae-Hyeok
JH
Lee
Tae-Il
TI
Yang
Mong
M
Cho
Ki-Tae
KT
Yoon
Seung-Kug
SK
Baik
Yong-Hee
YH
Han
D000328:Adult; D002114:Calcinosis / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D002540:Cerebral Cortex / Q000378:metabolism* / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D004198:Disease Susceptibility / Q000378:metabolism / Q000473:pathology; D006527:Hepatolenticular Degeneration / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male