Charge-tagged acetate ligands as mass spectrometry probes for metal complexes investigations: applications in Suzuki and Heck phosphine-free reactions.
An acetate anion bearing an imidazolium cation as its charge tag was reacted with M(OAc)(2) complexes (where M = Ni, Cu, and Pd; in situ reaction) to form members of a new class of charge-tagged metal complexes. The formation of these unprecedented precatalysts with potential for cross-coupling reactions was confirmed by electrospray ionization (and tandem) mass spectrometry. The catalytic performance of the palladium complex was tested in Heck and Suzuki cross-coupling reactions, often with superior activity and yields as compared with Pd(OAc)(2).
Laboratory of Medicinal and Technological Chemistry, Chemistry Institute, University of Brasília (UnB), Campus Universitário Darcy Ribeiro, CEP 70904-970, P.O. Box 4478, Brasília-DF, Brazil.
Felipe F D
FF
Oliveira
Marcelo R
MR
dos Santos
Priscila M
PM
Lalli
Eduardo M
EM
Schmidt
Peter
P
Bakuzis
Alexandre A M
AA
Lapis
Adriano L
AL
Monteiro
Marcos N
MN
Eberlin
Brenno A D
BA
Neto