Graham-Little-Piccardi-Lassueur syndrome.
Graham-Little-Piccardi-Lassueur syndrome (GLPLS) traditionally describes patients with a triad of a multifocal cicatricial alopecia of the scalp, noncicatricial alopecia of the axillae and groin, and a lichenoid follicular eruption. The entity has caused much controversy with respect to both etiology and clinical definition. We present a patient with lichen planopilaris, lichen planus pigmentosus, and nonscarring alopecia of the genitals, who is reminiscent of GLPLS. Recent work shows evidence for autoimmunity in GLPLS. Further elucidation of underlying mechanisms can improve categorization and treatment options in this rare and controversial syndrome.
Department of Dermatology, New York University, New York, New York, USA.
Neelam
N
Vashi
Tracey
T
Newlove
Julie
J
Chu
Rishi
R
Patel
Jennifer
J
Stein
D000328:Adult; D000505:Alopecia / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D001365:Axilla; D004318:Doxycycline / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006119:Groin; D006801:Humans; D006886:Hydroxychloroquine / Q000008:administration & dosage / Q000627:therapeutic use; D017495:Hyperpigmentation / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D008010:Lichen Planus / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D009333:Neck; D013577:Syndrome
D006886:Hydroxychloroquine; D004318:Doxycycline