[Exfoliative dermatitis as a side effect of intravenous immunoglobulin treatment].
Three patients with immune-mediated polyneuropathies developed rash, eczema, whole body scaling, vesicles in hands and loss of hair a few days after infusion of large doses of intravenous immunoglobulin (IVIG). The condition was diagnosed as exfoliative dermatitis. Two out of three patients were afterwards treated with low doses of IVIG slowly increased over a year given under the protection of oral steroids. Our findings indicate that exfoliative dermatitis can be provoked by IVIG treatment, and that the treatment can be reinstalled by slowly increasing the IVIG dose under steroid cover.
Neurologisk Afdeling F, Aarhus Universitetshospital, Aarhus Sygehus, Nørrebrogade 44, 8000 Aarhus C, Denmark. larsmark@rm.dk
Lars Høj
LH
Markvardsen
Johannes
J
Jakobsen
D000328:Adult; D003873:Dermatitis, Exfoliative / Q000139:chemically induced* / Q000473:pathology; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000009:adverse effects*; D007155:Immunologic Factors / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000188:drug therapy / Q000276:immunology; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000188:drug therapy / Q000276:immunology
D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors