PCR diagnosis of Pneumocystis pneumonia: a bivariate meta-analysis.
We undertook a bivariate meta-analysis to assess the overall accuracy of respiratory specimen PCR assays for diagnosing Pneumocystis pneumonia. The summary sensitivity and specificity were 0.99 (95% confidence interval, 0.96 to 1.00) and 0.90 (0.87 to 0.93). Subgroup analyses showed that quantitative PCR analysis and the major surface glycoprotein gene target had the highest specificity value (0.93). Respiratory specimen PCR results are sufficient to confirm or exclude the disease for at-risk patients suspected of having Pneumocystis pneumonia.
Department of Respiratory Diseases, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, People's Republic of China.
Yuan
Y
Lu
Guoya
G
Ling
Chenyi
C
Qiang
Qinshou
Q
Ming
Cong
C
Wu
Ke
K
Wang
Zouxiao
Z
Ying
D006801:Humans; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D009172:Mycology / Q000379:methods*; D011010:Pneumocystis / Q000235:genetics / Q000302:isolation & purification*; D011020:Pneumonia, Pneumocystis / Q000175:diagnosis*; D016133:Polymerase Chain Reaction / Q000379:methods*; D012680:Sensitivity and Specificity