Metalloproteinases in Drosophila to humans that are central players in developmental processes.
Many secreted proteins are synthesized as precursors with propeptides that must be cleaved to yield the mature functional form of the molecule. In addition, various growth factors occur in extracellular latent complexes with protein antagonists and are activated upon cleavage of such antagonists. Research in the separate fields of embryonic patterning and extracellular matrix formation has identified members of the BMP1/Tolloid-like family of metalloproteinases as key players in these types of biosynthetic processing events in species ranging from Drosophila to humans.
Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792.
Alison
A
Muir
Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792. Electronic address: dsgreens@wisc.edu.
Daniel S
DS
Greenspan
D000818:Animals; D055395:Bone Morphogenetic Protein 1 / Q000378:metabolism; D003094:Collagen / Q000378:metabolism; D004331:Drosophila melanogaster; D005109:Extracellular Matrix; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D045726:Metalloproteases / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D016212:Transforming Growth Factor beta / Q000378:metabolism; D014982:Xenopus laevis
D036341:Intercellular Signaling Peptides and Proteins; D016212:Transforming Growth Factor beta; D007334:Insulin-Like Growth Factor I; D003094:Collagen; D045726:Metalloproteases; D055395:Bone Morphogenetic Protein 1; C487826:ASTL protein, human