Phenanthrenes from Juncus effusus with anxiolytic and sedative activities.
Eight phenanthrenes, 7-carboxy-2-hydroxy-1-methyl-5-vinyl-phenanthrene (1); 2,7-dihydroxy-1-methyl-5-aldehyde-9,10-dihydrophenanthrene (2); dehydroeffusol (3); dehydrojuncusol (4); 7-carboxy-2-hydroxy-1-methyl-5-vinyl-9,10-dihydrophenanthrene (5); 8-carboxy-2-hydroxy-1-methyl-5-vinyl-9,10-dihydrophenanthrene (6); effusol (7) and juncusol (8), were isolated from the aerial part of Juncus effusus. Compounds 1 and 2 were identified as new constituents. Compounds 7 and 8 showed anxiolytic and sedative activities.
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, P.R. China.
Yong-Gang
YG
Wang
Yan-Long
YL
Wang
Hai-Feng
HF
Zhai
You-Jiao
YJ
Liao
Bing
B
Zhang
Jian-Mei
JM
Huang
D000818:Animals; D014151:Anti-Anxiety Agents / Q000737:chemistry* / Q000494:pharmacology*; D006993:Hypnotics and Sedatives / Q000737:chemistry* / Q000494:pharmacology*; D008124:Locomotion / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D010616:Phenanthrenes / Q000737:chemistry* / Q000494:pharmacology*; D035261:Plant Components, Aerial / Q000737:chemistry*; D006109:Poaceae / Q000737:chemistry*
D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D010616:Phenanthrenes