Estimation of dengue virus IgM persistence using regression analysis.
Dengue virus IgM persistence was estimated using follow-up sera from 98 patients (60 with primary infections and 38 with secondary infections) whose first-specimen IgM index was strongly positive, suggesting recent disease onset. Regression analysis of the follow-up IgM index versus days between samples yielded a trend line that reached the cut-point index (1.10) at 179 days for the primary infection group and 139 days for the secondary infection group. This difference reflected significantly higher first-sample IgM indices in primary infections than in secondary infections rather than differences in IgM decay rates.
Focus Diagnostics, Inc., Cypress, CA 90630, USA. hprince@focusdx.com
Harry E
HE
Prince
Jose L
JL
Matud
D000914:Antibodies, Viral / Q000097:blood*; D003715:Dengue / Q000276:immunology*; D003716:Dengue Virus / Q000276:immunology*; D005500:Follow-Up Studies; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D012044:Regression Analysis; D013997:Time Factors
D000914:Antibodies, Viral; D007075:Immunoglobulin M