Morgana and melusin: two fairies chaperoning signal transduction.
Chaperones and scaffold proteins are key elements involved in controlling the assembly of molecular complexes required for coordinated signal transduction. Here we describe morgana and melusin, two phylogenetically conserved chaperones that cooperate with Hsp90 and regulate signal transduction in important physiopathological processes. While morgana is ubiquitously expressed, melusin expression is restricted to striated muscles. Despite high sequence homology, the two chaperones have distinct functions. Morgana controls genomic stability by regulating the centrosome cycle via ROCKII kinase. Melusin, however, organizes ERK signal transduction in cardiomyocytes and regulates cardiac compensatory hypertrophy in response to different stress stimuli.
Dipartimento di Genetica, Biologia e Biochimica, Università di Torino, Molecular Biotechnology Center, Torino, Italy.
Roberta
R
Ferretti
Mauro
M
Sbroggiò
Augusta
A
Di Savino
Federica
F
Fusella
Alessandro
A
Bertero
Wojciech
W
Michowski
Guido
G
Tarone
Mara
M
Brancaccio
D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D003598:Cytoskeletal Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D019143:Evolution, Molecular; D020440:Gene Duplication; D051379:Mice; D008958:Models, Molecular; D018832:Molecular Chaperones / Q000737:chemistry / Q000502:physiology*; D009124:Muscle Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D017434:Protein Structure, Tertiary; D015398:Signal Transduction
D002352:Carrier Proteins; C478383:Chp-1 protein, mouse; D003598:Cytoskeletal Proteins; C122158:Itgb1bp2 protein, mouse; D018832:Molecular Chaperones; D009124:Muscle Proteins