Lichtheim 2: synthesizing aphasia and the neural basis of language in a neurocomputational model of the dual dorsal-ventral language pathways.
Traditional neurological models of language were based on a single neural pathway (the dorsal pathway underpinned by the arcuate fasciculus). Contemporary neuroscience indicates that anterior temporal regions and the "ventral" language pathway also make a significant contribution, yet there is no computationally-implemented model of the dual pathway, nor any synthesis of normal and aphasic behavior. The "Lichtheim 2" model was implemented by developing a new variety of computational model which reproduces and explains normal and patient data but also incorporates neuroanatomical information into its architecture. By bridging the "mind-brain" gap in this way, the resultant "neurocomputational" model provides a unique opportunity to explore the relationship between lesion location and behavioral deficits, and to provide a platform for simulating functional neuroimaging data.
Neuroscience and Aphasia Research Unit, School of Psychological Sciences, University of Manchester, Manchester M139PL, UK.
Taiji
T
Ueno
Satoru
S
Saito
Timothy T
TT
Rogers
Matthew A
MA
Lambon Ralph
D001037:Aphasia / Q000503:physiopathology*; D001921:Brain / Q000502:physiology* / Q000503:physiopathology; D003198:Computer Simulation; D006801:Humans; D007802:Language; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology* / Q000503:physiopathology; D009434:Neural Pathways / Q000502:physiology* / Q000503:physiopathology; D009474:Neurons / Q000502:physiology*