Enhanced depth imaging detects lamina cribrosa thickness differences in normal tension glaucoma and primary open-angle glaucoma.
OBJECTIVE
To confirm the advantages of the enhanced depth imaging (EDI) mode over the standard mode of the Heidelberg Spectralis spectral domain optical coherence tomography (SD-OCT) for imaging of the lamina cribrosa, and to compare laminar thicknesses of various glaucoma types with or without disc hemorrhage in a similar state of visual field loss.


METHODS
Cross-sectional, case-control design.


METHODS
We included 137 glaucoma patients and 49 healthy controls.


METHODS
Optic nerve head B-scans were obtained by both the standard and EDI modes of the Spectralis OCT. Laminar thickness was measured at the center of mid-superior, central, and mid-inferior horizontal B-scans. Laminar thickness in patients with normal tension glaucoma (NTG) was compared with that in patients with primary open-angle glaucoma (POAG). To verify the reproducibility of EDI imaging, intraclass correlation coefficients and test-retest variability were calculated from selected B-scans.


METHODS
Laminar thickness and mean deviation values on standard automatic perimetry.


RESULTS
The EDI OCT imaging showed significantly better intraobserver, interobserver, intravisit, and intervisit reproducibility than those by standard imaging. Laminar thickness in mid-superior, central, and mid-inferior regions was thinner in the POAG and NTG groups than in the normal control group (P<0.001). The mid-superior, central, and mid-inferior regions of the lamina were also significantly thinner in patients with NTG and disc hemorrhage than in those with NTG but no disc hemorrhage.


CONCLUSIONS
The EDI mode of the Heidelberg Spectralis SD-OCT detected differences in the lamina cribrosa by glaucoma type. The lamina cribrosa was thinner in NTG eyes and in NTG eyes with disc hemorrhage.


BACKGROUND
The authors have no proprietary or commercial interest in any of the materials discussed in this article.
Department of Ophthalmology and Visual Science, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Hae-Young Lopilly
HY
Park
So Hee
SH
Jeon
Chan Kee
CK
Park
D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D057066:Low Tension Glaucoma / Q000175:diagnosis*; D008875:Middle Aged; D015588:Observer Variation; D009898:Optic Disk / Q000473:pathology*; D015203:Reproducibility of Results; D012166:Retinal Hemorrhage / Q000473:pathology; D041623:Tomography, Optical Coherence; D014786:Vision Disorders / Q000175:diagnosis; D058609:Visual Field Tests; D014794:Visual Fields