Effects of abdominal sepsis in the healing of abdominal wall: experimental study in rats.
OBJECTIVE
To evaluate the influence of sepsis in the process of wound healing in the abdominal wall.


METHODS
40 rats divided into two groups of twenty animals: group of study (E) - septic, and the control group (C) - not septic. The two groups were divided into subgroups of 10 to be killed on the third day (n = 10) or seventh (n = 10) postoperative. Sepsis was induced by ligation and puncture of the cecum. We performed also the section and anastomosis in left colon. The synthesis of the abdominal wall was made with 3-0 silk thread. On the day of re-laparotomy, the abdominal wall was removed for analysis of the breaking strength and histopathological analysis.


RESULTS
The mean breaking strength was at third day: E group (1.44 ± 1.22) and C group (0.35 ± 0.46). At seventh day the mean breaking strength was: E group (13.01 ± 7.09) and C group (11.66 ± 7.38). There was statistical difference in tensile strength. E group at third day with control group (p = 0.019).


CONCLUSIONS
The induction of peritoneal sepsis reduced the breaking strength of the abdominal wall on the third day after surgery.
School of Medicine, UnB, Brasília, DF, Brazil.
Alexandre Malta
AM
Brandão
Naiara Galvão da
NG
Silva
Marcos Vinícius Melo de
MV
Oliveira
Pedro Henrique Alves de
PH
Morais
Silvana
S
Marques e Silva
João Batista de
JB
Sousa
Fabiana Pirani
FP
Carneiro
D034861:Abdominal Wall / Q000473:pathology / Q000601:surgery*; D000818:Animals; D002921:Cicatrix / Q000473:pathology / Q000503:physiopathology*; D004195:Disease Models, Animal; D008026:Ligation; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018805:Sepsis / Q000503:physiopathology*; D013718:Tensile Strength; D013997:Time Factors; D014945:Wound Healing / Q000502:physiology*