Intramolecular monomer-on-monomer (MoM) Mitsunobu cyclization for the synthesis of benzofused thiadiazepine-dioxides.
The utilization of a monomer-on-monomer (MoM) intramolecular Mitsunobu cyclization reaction employing norbornenyl-tagged (Nb-tagged) reagents is reported for the synthesis of benzofused thiadiazepine-dioxides. Facile purification was achieved via ring-opening metathesis (ROM) polymerization initiated by one of three metathesis catalyst methods: (i) free metathesis catalyst, (ii) surface-initiated catalyst-armed silica, or (iii) surface-initiated catalyst-armed Co/C magnetic nanoparticles.
Department of Chemistry, University of Kansas, Lawrence, KS 66045, USA.
Pradip K
PK
Maity
Quirin M
QM
Kainz
Saqib
S
Faisal
Alan
A
Rolfe
Thiwanka B
TB
Samarakoon
Fatima Z
FZ
Basha
Oliver
O
Reiser
Paul R
PR
Hanson
D001554:Benzene / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D003500:Cyclization; D053758:Nanoparticles / Q000737:chemistry; D013829:Thiadiazines / Q000138:chemical synthesis* / Q000737:chemistry*
D013829:Thiadiazines; D001554:Benzene