Brain-gut axis: from basic understanding to treatment of IBS and related disorders.
The present review describes advances in understanding the mechanisms and provide an update of present and promising therapy directed at the gut or the brain in the treatment of irritable bowel syndrome (IBS). The diagnosis of IBS typically is based on identification of symptoms, such as the Rome III criteria for IBS in adults and children. The criteria are similar in children and adults. The focus of the present review is the bowel dysfunction associated with IBS.
Clinical Enteric Neuroscience Translational and Epidemiological Research, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. camilleri.michael@mayo.edu
Michael
M
Camilleri
Carlo
C
Di Lorenzo
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D004195:Disease Models, Animal; D041981:Gastrointestinal Tract / Q000503:physiopathology*; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D016202:N-Methylaspartate / Q000037:antagonists & inhibitors; D011788:Quality of Life
D000893:Anti-Inflammatory Agents; D016202:N-Methylaspartate