Influence of metoclopramide on abdominal wall healing in rats subjected to colonic anastomosis in the presence of peritoneal sepsis induced.
OBJECTIVE
To evaluate the effects of metoclopramide on abdominal wall healing in rats in the presence of sepsis.


METHODS
40 rats divided into two groups of twenty animals, subdivided into two subgroups of 10 animals each: group (E) - treated with metoclopramide, and saline-treated control group. The two groups were divided into subgroups of 10 to be killed on the 3rd day (n = 10) or day 7 (n = 10) after surgery. Sepsis was induced by cecal ligation and puncture. We performed also the section and anastomosis in left colon. The synthesis of the abdominal wall was made with 3-0 silk thread. We measured the breaking strength of the abdominal wall and made the histopathological evaluation.


RESULTS
on 3rd day postoperative, the average breaking strength in the E group was 0.83 ± 0.66 and in group C was 0.35 ± 0.46 (p = 0.010). On the seventh day, the breaking strength in group E was 11.44 ± 5.07, in group C 11.66 ± 7.38 (p = 1.000). The E7 group showed lower inflammatory infiltration, foreign body reaction, fibrin than control.


CONCLUSIONS
animals treated with metoclopramide had a higher resistance of the abdominal wall on the 3rd postoperative day.
School of Medicine, UnB, Brasilia, DF, Brazil.
Naiara Galvão da
NG
Silva
Alexandre Malta
AM
Brandão
Marcos Vinícius Melo de
MV
Oliveira
Pedro Henrique Alves de
PH
Morais
Silvana
S
Marques e Silva
Fabiana Pirani
FP
Carneiro
João Batista de
JB
Sousa
D034861:Abdominal Wall / Q000601:surgery*; D000714:Anastomosis, Surgical; D000818:Animals; D003106:Colon / Q000601:surgery; D004195:Disease Models, Animal; D018492:Dopamine Antagonists / Q000494:pharmacology*; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D011184:Postoperative Period; D051381:Rats; D017208:Rats, Wistar; D018805:Sepsis / Q000503:physiopathology*; D013529:Surgical Wound Dehiscence / Q000503:physiopathology* / Q000517:prevention & control; D013718:Tensile Strength / Q000187:drug effects / Q000502:physiology; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
D018492:Dopamine Antagonists; D008787:Metoclopramide