Plasma fibrinogen: a possible link between job stress and cardiovascular disease among Chinese workers.
BACKGROUND
Little is known about the effect of effort-reward imbalance (ERI) on fibrinogen. We aimed to examine the association between ERI and fibrinogen among Chinese workers.


METHODS
A total of 732 subjects without vascular diseases were analyzed. Associations between job stress evaluated by ERI model and plasma fibrinogen were explored by multiple regression.


RESULTS
Effort, overcommitment, and ERI were significantly positively associated with fibrinogen, while reward was negatively related with fibrinogen both for men and for women. Compared with low level group, high level of effort, overcommitment, and ERI significantly increased risk of elevated fibrinogen (more than mean concentration) with adjusted OR of 3.3, 12.5, and 7.7 for men; 2.9, 7.2, and 7.2 for women, respectively; however, high reward reduced 80% risk for elevated fibrinogen.


CONCLUSIONS
Effort, overcommitment, and ERI are significantly associated with fibrinogen among Chinese workers. High fibrinogen may be a possible link between job stress and cardiovascular disease.
Department of Cardiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, No 49 North Garden Road, Haidian District, Beijing, China.
Weixian
W
Xu
Juan
J
Hang
Lijun
L
Guo
Yiming
Y
Zhao
Zhaoping
Z
Li
Wei
W
Gao
D000223:Adaptation, Psychological; D000328:Adult; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D002681:China / Q000453:epidemiology; D016001:Confidence Intervals; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D006801:Humans; D016014:Linear Models; D008297:Male; D009784:Occupational Diseases / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D016273:Occupational Exposure / Q000009:adverse effects*; D016017:Odds Ratio; D011594:Psychometrics; D018570:Risk Assessment; D013315:Stress, Psychological / Q000150:complications*
D005340:Fibrinogen