Serotypes and virulence genes of extraintestinal pathogenic Escherichia coli isolates from diseased pigs in China.
Extraintestinal pathogenic Escherichia coli (ExPEC) isolates were detected in 315/3127 (10.1%) diseased pigs from 19 provinces of China; the frequency of isolation increased from 3.1% in 2004 to 14.6% in 2007. All isolates were characterised for O serogroups, haemolysis, phenotypic and genotypic antimicrobial resistance, virulence genes and pathogenicity. The most prevalent serogroups were O161, O8, O11, O138, O101 and O26; 83/315 (26.3%) isolates were haemolytic. Forty percent of isolates in phylogenetic groups B2 and D were highly virulent porcine ExPEC strains. Thirty-three putative extraintestinal virulence factor genes that are normally associated with human and/or avian ExPEC strains were widely present in porcine isolates. These results indicate that ExPEC are prevalent in pigs in China and represent a potential public health threat.
State Key Laboratory of Agricultural Microbiology, Laboratory of Animal Infectious Diseases, College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, China.
Chen
C
Tan
Xibiao
X
Tang
Xuan
X
Zhang
Yi
Y
Ding
Zhanqin
Z
Zhao
Bin
B
Wu
Xuwang
X
Cai
Zhengfei
Z
Liu
Qigai
Q
He
Huanchun
H
Chen
D000818:Animals; D002681:China / Q000453:epidemiology; D004926:Escherichia coli / Q000145:classification* / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000453:epidemiology / Q000382:microbiology / Q000662:veterinary*; D005260:Female; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D010802:Phylogeny; D012703:Serotyping; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology / Q000382:microbiology*; D014774:Virulence; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism
D037521:Virulence Factors