Anti-staphylococcal activity and β-lactam resistance attenuating capacity of structural analogues of (-)-epicatechin gallate.
We examined the impact of gradual removal of hydroxyl groups from the A- and B-rings of (-)-epicatechin gallate on antibacterial activity and oxacillin resistance attenuation of an epidemic strain of methicillin resistant Staphylococcus aureus. Removal of both hydroxyls from the B-ring effected a large reduction in oxacillin MIC (from 512 to 0.25 mg/mL at a concentration of 12.5 mg/L); further hydroxyl deletion of the A-ring reduced the oxacillin effect but increased intrinsic anti-staphylococcal activity.
Department of Chemistry, University College London, London, UK. j.c.anderson@ucl.ac.uk
James C
JC
Anderson
Robert A
RA
McCarthy
Sarah
S
Paulin
Peter W
PW
Taylor
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002392:Catechin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D006900:Hydroxylation; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010068:Oxacillin / Q000494:pharmacology; D018440:beta-Lactam Resistance / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D002392:Catechin; C062669:epicatechin gallate; D010068:Oxacillin