The impact of HIV on maternal morbidity in the Pre-HAART era in Uganda.
OBJECTIVE
To compare maternal morbidity in HIV-infected and uninfected pregnant women.


METHODS
Major maternal morbidity (severe febrile illness, illnesses requiring hospital admissions, surgical revisions, or illnesses resulting in death) was measured prospectively in a cohort of HIV-infected and uninfected women followed from 36 weeks of pregnancy to 6 weeks after delivery. Odds ratios of major morbidity and associated factors were examined using logistic regression.


RESULTS
Major morbidity was observed in 46/129 (36%) and 104/390 (27%) of the HIV-infected and HIV-uninfected women, respectively, who remained in followup. In the multivariable analysis, major morbidity was independently associated with HIV infection, adjusted odds ratio (AOR) 1.7 (1.1 to 2.7), nulliparity (AOR 2.0 (1.3 to 3.0)), and lack of, or minimal, formal education (AOR 2.1 (1.1 to 3.8)).


CONCLUSIONS
HIV was associated with a 70% increase in the odds of major maternal morbidity in these Ugandan mothers.
ICAP, Mailman School of Public Health, Columbia University, P.O. Box 3567, Kampala, Uganda. hn2158@columbia.edu
Harriet
H
Nuwagaba-Biribonwoha
Richard T
RT
Mayon-White
Pius
P
Okong
Peter
P
Brocklehurst
Lucy M
LM
Carpenter
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005334:Fever / Q000453:epidemiology / Q000209:etiology; D005500:Follow-Up Studies; D015658:HIV Infections / Q000150:complications*; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D016015:Logistic Models; D008428:Maternal Mortality; D009017:Morbidity; D015999:Multivariate Analysis; D016017:Odds Ratio; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology / Q000209:etiology* / Q000601:surgery; D011251:Pregnancy Complications, Infectious; D011446:Prospective Studies; D012307:Risk Factors; D013514:Surgical Procedures, Operative / Q000706:statistics & numerical data; D014454:Uganda / Q000453:epidemiology