Fungal Smn and Spf30 homologues are mainly present in filamentous fungi and genomes with many introns: implications for spinal muscular atrophy.
Spinal muscular atrophy is an important rare genetic disease characterized by the loss of motor neurons, where the main gene responsible is smn1. Orthologous genes have only been characterized in a single fungal genome: Schizosaccharomyces pombe. We have searched for putative SMN orthologues in publically available fungal genomes, finding that they are predominately present in filamentous fungi. SMN binding partners and the SPF30 SMN paralogue, which are all involved in mRNA splicing, were found to be present in a similar but non-identical subset of fungal genomes. The Saccharomycces cerevisiae yeast genome contains neither smn1 orthologues nor paralogues and it has been suggested that this might be related to the low number of introns in this yeast. Here we have tested this hypothesis by looking at other fungal genomes. Significantly, we find that fungal genomes with high numbers of introns also possess an SMN orthologue or at least its paralogue, SPF30.
Centro Andaluz de Biología del Desarrollo, CSIC-UPO, Facultad de Ciencias Experimentales (Área de Genética), Universidad Pablo de Olavide, 41013 Sevilla, Spain.
Pablo
P
Mier
Antonio J
AJ
Pérez-Pulido
D005658:Fungi / Q000235:genetics*; D016681:Genome, Fungal; D006801:Humans; D007438:Introns; D009134:Muscular Atrophy, Spinal / Q000235:genetics; D010802:Phylogeny; D000072260:RNA Splicing Factors; D055532:SMN Complex Proteins / Q000235:genetics*; D016415:Sequence Alignment
D000072260:RNA Splicing Factors; D055532:SMN Complex Proteins; C526478:SMNDC1 protein, human