First report of reproductive assistance in a woman affected by May-Hegglin anomaly.
OBJECTIVE
To report the first case of fertility treatment in a patient with May-Hegglin anomaly, a rare hematological disorder inherited as an autosomal dominant trait.


METHODS
We present a case report of a 40-year-old nulliparous patient with May-Hegglin anomaly who underwent her first ICSI cycle with transfer of three fresh embryos.


RESULTS
Prophylactic platelet transfusion obtained by single-donor apheresis was performed 1 h before the oocyte pick up. No complications were reported. No pregnancy was obtained.


CONCLUSIONS
We report about the possibility to assist women affected by May-Hegglin anomaly requiring reproductive assistance. However, a multidisciplinary team composed of gynecologists and hematologists should follow such patients carefully, in order to carry out a complete clinical evaluation and to prevent the potential risks of bleeding. Clinicians must be vigilant in their presentation of risks, benefits, and alternatives.
Valeria
V
Savasi
Arianna
A
Laoreti
Massimiliano
M
Elli
Tiziano
T
Brambilla
Augusto
A
Federici
Irene
I
Cetin
D000328:Adult; D004624:Embryo Transfer; D005260:Female; D006319:Hearing Loss, Sensorineural; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D017713:Platelet Transfusion; D013921:Thrombocytopenia / Q000150:complications* / Q000151:congenital