PRINCIPLE: a tool for associating genes with diseases via network propagation.
CONCLUSIONS
PRINCIPLE is a Java application implemented as a Cytoscape plug-in, based on a previously published algorithm, PRINCE. Given a query disease, it prioritizes disease-related genes based on their closeness in a protein-protein interaction network to genes causing phenotypically similar disorders to the query disease.


BACKGROUND
Implemented in Java, PRINCIPLE runs over Cytoscape 2.7 or newer versions. Binaries, default input files and documentation are freely available at http://www.cs.tau.ac.il/~bnet/software/PrincePlugin/.


BACKGROUND
roded@tau.ac.il; assafgot@tau.ac.il.
The Balavatnik School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel. assafgot@tau.ac.il
Assaf
A
Gottlieb
Oded
O
Magger
Igor
I
Berman
Eytan
E
Ruppin
Roded
R
Sharan
D000465:Algorithms; D004194:Disease / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D060066:Protein Interaction Maps; D012984:Software