[Preparation and characterization of niosomes of Semen Strychni alkaloids extract].
OBJECTIVE
To prepare a noisome formulation of Semen Strychni alkaloids extract with high encapsulation efficiency.


METHODS
S. Strychni alkaloids were encapsulated into niosomes by pH gradient loading method. The factors influencing on the encapsulation efficiency were investigated, and formulation and preparation process of niosomes were optimised and validated.


RESULTS
When the drug to lipid weight ratio was under 1: 10, pH gradient in buffer solution of citric acid at 50 degrees C was more than 4.0, the niosomes (mean diameter 179.2 nm and Zeta potential -25.41 mV) were formed with encapsulation efficiency of over 86.9%.


CONCLUSIONS
The pH gradient loading method was reliable for preparing niosomes of Semen Strychni alkaloids extract.
Institute of Beijing Increase Biological Products, Beijing 102209, China.
Jie
J
Hu
Zhenzhen
Z
Wu
Kefei
K
Hu
Weihua
W
Zhang
Baoxian
B
Zhang
D000470:Alkaloids / Q000737:chemistry*; D002214:Capsules; D004339:Drug Compounding / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008081:Liposomes / Q000737:chemistry*; D031461:Strychnos nux-vomica / Q000737:chemistry*; D013696:Temperature
D000470:Alkaloids; D002214:Capsules; D004365:Drugs, Chinese Herbal; D008081:Liposomes