Guided delivery of adeno-associated viral vectors into the primate brain.
In this review, we discuss recent developments in the delivery of adeno-associated virus-based vectors (AAV), particularly with respect to the role of axonal transport in vector distribution in the brain. The use of MRI-guidance and new stereotactic aiming devices have now established a strong foundation for neurological gene therapy to become an accepted procedure in interventional neurology.
Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94103–0555, USA.
Ernesto A
EA
Salegio
Lluis
L
Samaranch
Adrian P
AP
Kells
John
J
Forsayeth
Krystof
K
Bankiewicz
D000818:Animals; D001921:Brain / Q000502:physiology* / Q000821:virology; D000229:Dependovirus / Q000235:genetics; D018014:Gene Transfer Techniques / Q000295:instrumentation; D015316:Genetic Therapy / Q000295:instrumentation / Q000379:methods; D005822:Genetic Vectors / Q000008:administration & dosage* / Q000235:genetics; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods