Transplantation of oligodendrocyte precursor cells improves myelination and promotes functional recovery after spinal cord injury.
Loss of oligodendrocytes and demyelination further impair neural function after spinal cord injury (SCI). Replacement of lost oligodendrocytes and improvement of myelination have a therapeutic significance in treatment of SCI. Here, we transplanted oligodendrocyte precursor cells (OPCs) to improve myelination in a rat model of contusive SCI. The labelled OPCs were transplanted to injured cord 7 days after injury. As a result, the implanted cells still survived in vivo 8 weeks after transplantation. They proliferated, integrated and differentiated in the injured cord. In the OPCs-treated rats, enhanced myelination in the lesioned area was observed and substantial improvement of motor function and nerve conduction was also recorded. Thus, this study provides strong evidence to support that transplantation of OPCs could improve myelination of injured cord and enhance functional recovery after contusive SCI.
Department of Orthopedics, 88th Hospital, Tai'an, Shandong, China.
Bo
B
Wu
Lei
L
Sun
Peijia
P
Li
Min
M
Tian
Yongzhong
Y
Luo
Xianjun
X
Ren
D000818:Animals; D002454:Cell Differentiation; D002478:Cells, Cultured; D003711:Demyelinating Diseases / Q000473:pathology* / Q000628:therapy; D004195:Disease Models, Animal; D005260:Female; D007150:Immunohistochemistry; D009186:Myelin Sheath / Q000473:pathology*; D009431:Neural Conduction; D009836:Oligodendroglia / Q000473:pathology / Q000637:transplantation*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function; D013119:Spinal Cord Injuries / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D033581:Stem Cell Transplantation