Stable triplex formation using the strong stacking effect of consecutive thionucleoside moieties.
In this study, it was found that the arrangement of consecutive thiocarbonyl groups of s(2)T and m(5)s(2)C remarkably stabilized the pre-protonated form of the triplex, and that the stabilization of the pre-protonated form increased the pKa value of a cytosine derivative in the triplex.
Department of Life Science, Tokyo Institution of Technology, Yokohama 226-8501, Japan.
Akihiro
A
Ohkubo
Yudai
Y
Nishino
Akira
A
Yokouchi
Yu
Y
Ito
Yasuhiro
Y
Noma
Yuuki
Y
Kakishima
Yoshiaki
Y
Masaki
Hirosuke
H
Tsunoda
Kohji
K
Seio
Mitsuo
M
Sekine
D001483:Base Sequence; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D013872:Thionucleosides / Q000737:chemistry*
D013872:Thionucleosides; C051802:triplex DNA; D004247:DNA