Combination effect of fluoride dentifrices and varnish on deciduous enamel demineralization.
The aim of this study was to evaluate the anticaries potential of 500 or 1100 ppm F dentifrices combined with fluoride varnish using a pH-cycling regimen. Seventy primary canines were covered with nail polish, leaving a 4×4 mm window on their buccal surface, and randomly assigned into 7 groups (n = 10): S: sound enamel not submitted to the pH-cycling regimen or treatment; N: negative control, submitted to the pH-cycling regimen without any treatment; D1 and D2: subjected to the pH-cycling regimen and treated twice daily with 1100 or 500 ppm F dentifrice, respectively; VF: fluoride varnish (subjected to F-varnish before and in the middle of the pH-cycling regimen); and VF+D1 and VF+D2. After 10 days, the teeth were sectioned, and enamel demineralization was assessed by cross-sectional hardness at different distances from the dental surface. Data were analyzed using a two-way ANOVA followed by Tukey's test. Dentifrice with 1100 ppm F and the combination of F-varnish with the dentifrices significantly reduced enamel demineralization compared with the negative control (p < 0.05), but the isolated effects of F-varnish and dentifrice with low concentration were not significant (p > 0.05). The effect of combining F-varnish with the dentifrices was not greater than the effect of the dentifrices alone (p < 0.05). The data suggest that the combination of F-varnish with dentifrices containing 500 and 1100 ppm F is not more effective in reducing demineralization in primary teeth than the isolated effect of dentifrice containing 1100 ppm F.
Departamento de Odontopediatria, Faculdade de Odontologia, São Leopoldo Mandic, Campinas, SP, Brazil.
Alessandra
A
Gatti
Lucila Basto
LB
Camargo
José Carlos Pettorossi
JC
Imparato
Fausto Medeiros
FM
Mendes
Daniela Prócida
DP
Raggio
D000704:Analysis of Variance; D003743:Dental Enamel / Q000187:drug effects*; D003802:Dentifrices / Q000737:chemistry / Q000494:pharmacology*; D005459:Fluorides / Q000737:chemistry / Q000494:pharmacology*; D006245:Hardness Tests; D006801:Humans; D006863:Hydrogen-Ion Concentration; D013499:Surface Properties; D013997:Time Factors; D017001:Tooth Demineralization / Q000517:prevention & control*; D014094:Tooth, Deciduous
D003802:Dentifrices; D005459:Fluorides