Metabolic syndrome in female patients with overactive bladder.
OBJECTIVE
To investigate the relevance of metabolic syndrome in the etiopathogenesis of overactive bladder in female patients. It has been shown that obesity has been associated with overactive bladder (OAB), and the metabolic syndrome and insulin resistance have been related to the annual growth rates of prostate and lower urinary tract symptoms.


METHODS
Female patients applying to our policlinics with OAB symptoms or other urologic complaints were enrolled in the study. The International Diabetes Federation criteria were used for the definition of the metabolic syndrome. The chi-square, Student t, and Mann-Whitney U tests and logistic regression analyses were used to compare differences in the variables.


RESULTS
The metabolic syndrome was diagnosed in 201 (64%) of 313 patients with OAB and 73 (35%) of 208 patients without OAB. The difference was statistically significant (P=.002). A larger waist circumference, greater body mass index, low high-density lipoprotein level, and incidence of hypertension were significantly greater statistically in the OAB group than in the controls.


CONCLUSIONS
The metabolic syndrome correlates highly with OAB in female patients. The metabolic syndrome can be an etiologic pathway for the onset of symptoms.
Department of Urology, Rize University School of Medicine, Rize, Turkey. hakuzun@yahoo.com
Hakkı
H
Uzun
Orhan Ünal
OÜ
Zorba
D000328:Adult; D017677:Age Distribution; D001774:Blood Chemical Analysis; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D015897:Comorbidity; D005260:Female; D006801:Humans; D016015:Logistic Models; D024821:Metabolic Syndrome / Q000175:diagnosis* / Q000453:epidemiology*; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D012016:Reference Values; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D053201:Urinary Bladder, Overactive / Q000175:diagnosis* / Q000453:epidemiology*; D055105:Waist Circumference
D001786:Blood Glucose