Fragile X mental retardation protein and stem cells.
Stem cells, which can self-renew and produce different cell types, are regulated by both extrinsic signals and intrinsic factors. Fragile X syndrome, one of the most common forms of inherited mental retardation, is caused by the functional loss of fragile X mental retardation protein (FMRP). FMRP is a selective RNA-binding protein that forms a messenger ribonucleoprotein (mRNP) complex that associates with polyribosomes. Recently, the role of Fmrp in stem cell biology has been explored in both Drosophila and the mouse. In this chapter, we discuss the role of FMRP in regulating the proliferation and differentiation of stem cells.
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Abrar
A
Qurashi
Xuekun
X
Li
Peng
P
Jin
D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D004330:Drosophila / Q000166:cytology / Q000502:physiology; D051860:Fragile X Messenger Ribonucleoprotein 1 / Q000235:genetics / Q000378:metabolism*; D005600:Fragile X Syndrome / Q000503:physiopathology; D006801:Humans; D051379:Mice; D013234:Stem Cells / Q000502:physiology*
D051860:Fragile X Messenger Ribonucleoprotein 1