[Methanol poisoning in a 61-year old male with recently diagnosed diabetes--a case report].
The aim of this paper is to present a case of a 61-year-old male transferred to the Regional Center of Clinical Toxicology from the Department of Endocrinology with suspected methanol poisoning. The patient presented symptoms of diabetes with extreme hyperglycemia >1600 mg/dl and nonketotic hyperosmolar coma. Laboratory tests showed metabolic/respiratory acidosis, methanol 80 mg/dl, ethanol 0.47 g/l, creatinine 3.5 mg/dl, urea 140 mg/dl, lactic acid 4.11 mmol/l, myoglobin >1000 ng/ml, HbA1C >14.5%. During a few days prior to the hospitalization the patient was drinking a great amount of fruit juices and milk (a dozen or so litres per twenty four hours). The eventuality of metabolizing glucose and aspartame into methanol is known from professional literature. The possibility of excessive consumption of aspartame and its metabolites causing methanol poisoning in the presented patient was considered.
Samodzielny Publiczny Szpital Wojewódzki im. Jana Bozego w Lublinie, Regionalny Ośrodek Toksykologii Klinicznej. szponar.jarek@gmail.com
Jarosław
J
Szponar
Agnieszka
A
Górska
Magdalena
M
Majewska
Michał
M
Tchórz
Grzegorz
G
Drelich
D000818:Animals; D001218:Aspartame / Q000378:metabolism* / Q000506:poisoning*; D001628:Beverages / Q000506:poisoning; D002417:Cattle; D048909:Diabetes Complications / Q000175:diagnosis; D003920:Diabetes Mellitus / Q000175:diagnosis*; D062787:Drug Overdose; D005638:Fruit / Q000506:poisoning*; D006801:Humans; D006944:Hyperglycemic Hyperosmolar Nonketotic Coma / Q000209:etiology*; D008297:Male; D000432:Methanol / Q000097:blood / Q000506:poisoning*; D008875:Middle Aged; D008892:Milk / Q000506:poisoning*
D000432:Methanol; D001218:Aspartame