[Rhabdomyolysis related to statin and seizures: report of 3 cases].
OBJECTIVE
To investigate the clinical features and prognosis of rhabdomyolysis related to seizure attacks and use of statin.


METHODS
The medical records of 3 patients with established diagnosis of rhabdomyolysis were analyzed and the related literatures were reviewed.


RESULTS
All the 3 patients had seizure attacks and/or used statin before the onset of rhabdomyolysis. Two of the patients complained of back pain, and all the 3 patients had dark-colored urine. Serum levels of creatine kinase (CK) were markedly increased by over 50 times above the normal upper limit. CK level kept increasing even after proper interventions, till reaching the peak level about 3 days later. The patients improved rapidly with full recovery thereafter, and CK became normal in 2 weeks. None of the patients had renal failure.


CONCLUSIONS
Seizure attacks and use of statin are common risk factors for non-traumatic rhabdomyolysis. Caution needs to be taken when prescribing statin to patients with recent seizure attacks. Special attention should be given to such early symptoms as muscle pain, weakness and dark-colored urine, and CK level monitoring is advisable in such cases.
Department of Neurology, Southern Medical University, Guangzhou, China. guanyqww@gmail.com
Yu-qing
YQ
Guan
Yan-jie
YJ
Shi
Qun
Q
Wang
D002544:Cerebral Infarction / Q000188:drug therapy; D003402:Creatine Kinase / Q000097:blood*; D004827:Epilepsy / Q000150:complications*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D008148:Lovastatin / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000201:enzymology / Q000209:etiology*; D019821:Simvastatin / Q000009:adverse effects / Q000627:therapeutic use
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008148:Lovastatin; D019821:Simvastatin; D003402:Creatine Kinase