Antitumour activity of Terminalia arjuna leaf against Ehrlich ascites carcinoma in mice.
Terminalia arjuna Roxb. (Combretaceae), commonly known as 'Arjuna', is a large tree occurring throughout the Indian peninsula. This study was undertaken to evaluate the methanol extract of T. arjuna leaf (META) for antitumour activity against Ehrlich ascites carcinoma (EAC) in Swiss albino mice. Twenty-four hours after intraperitonial inoculation of tumour (EAC) cells in mice, META was administered at 100 and 200 mg kg(-1) body weights for 9 consecutive days. On day 10, half of the mice were sacrificed and the rest kept alive for an assessment of the increase in life span. The antitumour effect of META was assessed by evaluating tumour volume, tumour weight, viable and non-viable tumour cell counts, median survival time and increase in life span of EAC-bearing hosts. Haematological profiles were estimated. META showed a significant (p<0.001) decrease in tumour volume, tumour weight and viable cell count, and also increased the life span of EAC-bearing mice. Haematological profiles were significantly (p<0.001) restored to normal levels in META-treated mice compared to the EAC control. Therefore, from this study, it can be concluded that T. arjuna leaf exhibited remarkable antitumour activity against EAC in Swiss mice.
Bengal Institute of Pharmaceutical Sciences, Kalyani , Nadia 741235, India.
Moulisha
M
Biswas
Sanjib
S
Bhattacharya
Ashoke K
AK
Ghosh
R B Suresh
RB
Kumar
Samit
S
Bera
Malaya
M
Gupta
Pallab K
PK
Haldar
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology* / Q000633:toxicity; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology*; D007928:Lethal Dose 50; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D029766:Terminalia / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts