Coping with parvovirus infections in mice: health surveillance and control.
Parvoviruses of mice, minute virus of mice (MVM) and mouse parvovirus (MPV), are challenging pathogens to eradicate from laboratory animal facilities. Due to the impediment on rodent-based research, recent studies have focused on the assessment of re-derivation techniques and parvoviral potential to induce persistent infections. Summarizing recent data, this review gives an overview on studies associated with parvoviral impact on research, diagnostic methods, parvoviral persistence and re-derivation techniques, demonstrating the complex nature of parvovirus infection in mice and unfolding the challenge of controlling parvovirus infections in laboratory animal facilities.
Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.
Lydia M
LM
Janus
Andre
A
Bleich
D000818:Animals; D051379:Mice; D008915:Minute Virus of Mice / Q000276:immunology / Q000502:physiology*; D010322:Parvoviridae Infections / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control / Q000662:veterinary*; D017992:Parvovirus / Q000276:immunology / Q000502:physiology*; D015995:Prevalence; D012376:Rodent Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control* / Q000821:virology