[Determination of supermolecular inclusion constants of hydroxylpropyl-beta-cylcodextrin with imperatorin and isoimperatorin by phase solubility method].
OBJECTIVE
To study the supermolecular interaction between different concentrations of hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and imperatorin (IM) and isoimperatorin (ISO) using phase solubility analysis.


METHODS
Different concentrations of hydroxypropyl-beta-cyclodextrin were prepared, added overdose of imperatorin or isoimperatorin, made a phase solubility diagram.


RESULTS
The relationship of phase solubility was approximatively linear and the model of inclusion compound was AL and the inclusion ratio of IM, ISO versus HP-beta-CD was 1: 1. The inclusion constants were 214.4, 587.2 L/mol respectively.


CONCLUSIONS
Supermolecular inclusion of HP-beta-CD of imperatorin/isoimperatorin could evidently increase the solubility of imperatorin and isoimperatorin, the enhancing effect of isoimperatorin solubility is better than that of imperatorin.
School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China. lcxjtu.2009@stu.xjtu.edu.cn
Cong
C
Li
Chang-he
CH
Wang
Ai-guo
AG
Zeng
Xin
X
Yang
Guang-de
GD
Yang
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000327:Adsorption; D004339:Drug Compounding / Q000379:methods; D004355:Drug Stability; D011564:Furocoumarins / Q000737:chemistry*; D012995:Solubility; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet / Q000379:methods*; D014867:Water / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000008:administration & dosage / Q000737:chemistry*
D011564:Furocoumarins; D012996:Solutions; D047392:beta-Cyclodextrins; D014867:Water; C055542:isoimperatorin; D000073738:2-Hydroxypropyl-beta-cyclodextrin; C031534:imperatorin