Contemporary management of nonfunctioning pancreatic neuroendocrine tumors.
BACKGROUND
This article reviews the current literature and recommendations pertaining to the management of nonfunctioning pancreatic neuroendocrine tumors.


CONCLUSIONS
In recent years the detection of nonfunctioning pancreatic neuroendocrine tumors has increased coincident with the increased use of cross-sectional imaging and is now thought to represent 2-10% of all pancreatic tumors. Improved understanding of the biology and behavior of these heterogeneous tumors is needed to guide therapy. The present review discusses diagnostics, therapeutics including emerging molecular analytics, and surveillance recommendations.
Department of Surgery, University of Michigan, 1500 East Medical Center Drive, SPC 5343, Taubman Center TC 2210D, Ann Arbor, MI 48109-5343, USA. rminter@umich.edu
Rebecca M
RM
Minter
Diane M
DM
Simeone
D014408:Biomarkers, Tumor / Q000378:metabolism; D019160:Endosonography; D006801:Humans; D016031:Liver Transplantation; D008279:Magnetic Resonance Imaging; D009367:Neoplasm Staging; D018358:Neuroendocrine Tumors / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism / Q000628:therapy; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism / Q000628:therapy; D011159:Population Surveillance; D011379:Prognosis; D014057:Tomography, X-Ray Computed
D014408:Biomarkers, Tumor