The function of cyclic-adenosine monophosphate responsive element-binding protein in hematologic malignancies.
Central to discovering novel approaches to treating leukemias and lymphomas is a clear understanding of the signaling networks which lead to unchecked cell cycle progression, proliferation, and survival. Cyclic-adenosine monophosphate (cAMP) responsive element-binding protein (CREB) represents a critical integrator of numerous signals from cytoplasmic kinase cascades, and is directly involved in controlling the transcription of genes critical for normal cellular proliferation and survival. Several lines of evidence implicate CREB as a proto-oncogene, as a number of translocations involving CREB and dysregulation of expression are both associated with oncogenesis. Thus, CREB represents a potential therapeutic target in leukemia. Here, we review CREB function and regulation in normal and aberrant hematopoiesis.
Division of Pediatric Hematology/Oncology, Mattel Children's Hospital UCLA, Los Angeles, CA 90095-1752, USA.
Bryan
B
Mitton
Er-Chieh
EC
Cho
Grace I
GI
Aldana-Masangkay
Kathleen M
KM
Sakamoto
D000818:Animals; D002470:Cell Survival / Q000235:genetics; D017362:Cyclic AMP Response Element-Binding Protein / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015972:Gene Expression Regulation, Neoplastic; D019337:Hematologic Neoplasms / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D006410:Hematopoiesis / Q000235:genetics / Q000502:physiology*; D006801:Humans; D010766:Phosphorylation; D000090063:Proto-Oncogene Mas; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*
D017362:Cyclic AMP Response Element-Binding Protein; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas