Efficacy of an intervention for families living with HIV in Thailand: a randomized controlled trial.
This study evaluates the efficacy of an intervention for persons living with HIV (PLH) and their family members in Thailand. A randomized controlled trial of 813 PLH and family members was carried out at four district hospitals in Thailand. Participants completed Computer Assisted Personal Interview assessments at baseline, 6, 12, 18, and 24 months. The primary outcome was quality of life (QoL); other measures included depressive symptoms and family functioning. Relative to the standard care condition, the intervention group reported significantly improved QoL at 6 months (P = 0.0014). When the intervention efficacy was stratified by baseline depressive symptoms (low vs. high), intervention efficacy was observed only among those with low depressive symptoms. Study findings suggest that the intervention was more efficacious for participants with less depressive symptoms and better family functioning. Extensive interventions may be optimal for those who have the capacity to learn the tools and skills.
Semel Institute for Neuroscience and Human Behavior, Center for Community Health, University of California at Los Angeles, 10920 Wilshire Blvd., Suite 350, Los Angeles, CA 90024, USA. lililili@ucla.edu
Li
L
Li
Li-Jung
LJ
Liang
Sung-Jae
SJ
Lee
Sopon
S
Iamsirithaworn
Dai
D
Wan
Mary Jane
MJ
Rotheram-Borus
D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D003863:Depression / Q000453:epidemiology / Q000523:psychology* / Q000628:therapy; D005190:Family / Q000523:psychology*; D005260:Female; D005500:Follow-Up Studies; D006679:HIV Seropositivity / Q000188:drug therapy / Q000453:epidemiology / Q000523:psychology*; D006801:Humans; D008297:Male; D017063:Outcome Assessment, Health Care; D011785:Quality Assurance, Health Care; D011788:Quality of Life; D012944:Social Support; D011795:Surveys and Questionnaires; D013785:Thailand / Q000453:epidemiology
D019380:Anti-HIV Agents