A review of clinical and histological parameters associated with contralateral neck metastases in oral squamous cell carcinoma.
Oral squamous cell carcinoma (OSCC) has a high incidence of cervical micrometastases and sometimes metastasizes contralaterally because of the rich lymphatic intercommunications relative to submucosal plexus of oral cavity that freely communicate across the midline, and it can facilitate the spread of neoplastic cells to any area of the neck consequently. Clinical and histopathologic factors continue to provide predictive information to contralateral neck metastases (CLNM) in OSCC, which determine prophylactic and adjuvant treatments for an individual patient. This review describes the predictive value of clinical-histopathologic factors, which relate to primary tumor and cervical lymph nodes, and surgical dissection and adjuvant treatments. In addition, the indications for elective contralateral neck dissection and adjuvant radiotherapy (aRT) and strategies for follow-up are offered, which is strongly focused by clinicians to prevent later CLNM and poor prognosis subsequently.
Department of Oral and Maxillofacial Surgery, Sun Yet-Sen Memorial Hospital (Second Affiliated Hospital) of Sun Yat-Sen University, Guangzhou 510120, China.
Song
S
Fan
Qiong-Lan
QL
Tang
Ying-Jin
YJ
Lin
Wei-Liang
WL
Chen
Jin-Song
JS
Li
Zhi-Quan
ZQ
Huang
Zhao-Hui
ZH
Yang
You-Yuan
YY
Wang
Da-Ming
DM
Zhang
Hui-Jing
HJ
Wang
Eduardo
E
Dias-Ribeiro
Qiang
Q
Cai
Lei
L
Wang
D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D009060:Mouth Floor / Q000473:pathology; D009062:Mouth Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D009333:Neck / Q000473:pathology; D037981:Neck Dissection; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant