Hedgehog rushes to the rescue of the developing cerebellum.
Premature birth often is associated with neurodevelopmental disabilities. In this issue of Science Translational Medicine, a pair of papers investigate--in patients and in a reliable animal model--the effects of glucocorticoids on cerebellar development after premature birth.
Inserm, U676, Hôpital Robert Debré, Paris 75019, France.
Olivier
O
Baud
Pierre
P
Gressens
D000818:Animals; D001930:Brain Injuries / Q000188:drug therapy*; D002531:Cerebellum / Q000187:drug effects* / Q000254:growth & development* / Q000293:injuries*; D003514:Cyclohexylamines / Q000627:therapeutic use*; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects*; D053823:Hedgehog Proteins / Q000819:agonists*; D006801:Humans; D008297:Male; D043562:Receptors, G-Protein-Coupled / Q000819:agonists*; D000072086:Smoothened Receptor; D013876:Thiophenes / Q000627:therapeutic use*
D003514:Cyclohexylamines; D005938:Glucocorticoids; D053823:Hedgehog Proteins; D043562:Receptors, G-Protein-Coupled; C468918:SAG compound; C465570:Shh protein, mouse; C491022:Smo protein, mouse; D000072086:Smoothened Receptor; D013876:Thiophenes