Crown ether functionalized texaphyrin monomers and dimers.
The synthesis and characterization of two 18-crown-6 functionalized analogues of an extensively studied gadolinium texaphyrin derivative, motexafin gadolinium (1, MGd), are reported. These are the monomeric and dimeric species, compounds 2 and 3, respectively. Both crown ether functionalized species proved to be stable at physiological pH and revealed distinct shifts in the UV spectrum when treated with sodium-, potassium-, ammonium- or zinc(II)-salts. Zinc(II) is believed to play a major role regulating apoptosis mechanisms in cancerous cells. Therefore, cytotoxicity studies of 2 and 3 were carried out using Ramos cell lines in the presence and absence of zinc(II).
Department of Chemistry & Biochemistry and Institute for Cellular and Molecular Biology, The University of Texas at Austin, 1-University Station A-5300, Austin, Texas 78712-0156, USA.
Christian
C
Preihs
Darren
D
Magda
Jonathan L
JL
Sessler