Early immunocastration of male pigs with Improvac(®) - effect on boar taint, hormones and reproductive organs.
The aim of this study was to investigate the effect of a vaccine against gonadotropin-releasing hormone (GnRH), Improvac(®) (Pfizer Ltd), administered at a pre- or early pubertal stage on boar taint, hormonal status and reproductive organs. Crossbred male pigs (Swedish Yorkshire dams×Swedish Landrace sires or Swedish Yorkshire sires, n=192) were at birth randomly allocated to four groups: one group of pigs surgically castrated without anaesthesia before age 1 week, a second group of early vaccinated pigs given Improvac at ages 10 and 14 weeks, a third group of standard vaccinated pigs given Improvac at ages 16 and 20 weeks, and a fourth group of entire male pigs. Following the second vaccine injection, antibody titres increased rapidly, accompanied by a rapid decrease in testosterone and a slower decrease of skatole in plasma to the same low levels as for surgically castrated pigs. At slaughter, the levels of androstenone and skatole in adipose tissue were low in surgically castrated and vaccinated pigs, whereas entire male pigs had elevated levels (p<0.001). Similarly, oestradiol was at low levels for surgically castrated and vaccinated pigs, whereas entire male pigs had elevated levels (p<0.001). IGF-1 was lowest for surgically castrated pigs and highest for entire male pigs, with vaccinated pigs at an intermediate level (p<0.001). At slaughter, reproductive organs were small in pigs vaccinated with Improvac, and smaller in pigs vaccinated early (p<0.001). Under our experimental conditions, early vaccination with Improvac can be used as an alternative to the recommended schedule with maintained control of boar taint and testicular secretory activity.
Department of Food Science, Swedish University of Agricultural Sciences, Box 7051, S-750 07 Uppsala, Sweden. carl.brunius@slu.se
Carl
C
Brunius
Galia
G
Zamaratskaia
Kristina
K
Andersson
Gang
G
Chen
Mattias
M
Norrby
Andrzej
A
Madej
Kerstin
K
Lundström
D000818:Animals; D000906:Antibodies / Q000097:blood / Q000276:immunology; D004958:Estradiol / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors* / Q000276:immunology*; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008297:Male; D009812:Odorants / Q000517:prevention & control; D009919:Orchiectomy; D009929:Organ Size; D012862:Skatole / Q000097:blood; D013552:Swine; D013737:Testis / Q000033:anatomy & histology / Q000276:immunology; D013739:Testosterone / Q000097:blood; D014612:Vaccines / Q000008:administration & dosage* / Q000276:immunology
D000906:Antibodies; D014612:Vaccines; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D004958:Estradiol; D007334:Insulin-Like Growth Factor I; D012862:Skatole