Stimulatory effect of antidepressant drug pretreatment on progression of B16F10 melanoma in high-active male and female C57BL/6J mice.
The effect of a two-week desipramine or fluoxetine (10 mg/kg, i.p.) pretreatment on B16F10 melanoma growth in 3-5 month old female and male C57BL/6J mice differing in behavioral characteristics (high- vs. low-active) was compared. Antidepressant pretreatment increased metastasis formation, shortened the survival, decreased splenocyte anti-tumor natural killer cell cytotoxicity (in vitro), and the pro-inflammatory cytokine IL-12p40, IFN-γ production while it increased anti-inflammatory cytokine IL-10 production in high-active males (desipramine) or females (fluoxetine). The obtained results emphasize a stimulatory effect of pretreatment with antidepressants on progress of B16F10 melanoma that depends on gender and behavioral characteristics of the animal.
Department of Experimental Neuroendocrinology, Institute of Pharmacology PAS, Smętna 12, 31-343 Kraków, Poland. kubera@if-pan.krakow.pl
Marta
M
Kubera
Beata
B
Grygier
Danuta
D
Wrona
Zofia
Z
Rogóż
Adam
A
Roman
Agnieszka
A
Basta-Kaim
Bogusława
B
Budziszewska
Monika
M
Leskiewicz
Danuta
D
Jantas
Wojciech
W
Nowak
Michael
M
Maes
Wladyslaw
W
Lason
D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage* / Q000633:toxicity; D045744:Cell Line, Tumor; D016207:Cytokines / Q000096:biosynthesis; D003601:Cytotoxicity Tests, Immunologic; D003891:Desipramine / Q000008:administration & dosage* / Q000633:toxicity; D018450:Disease Progression; D005260:Female; D005473:Fluoxetine / Q000008:administration & dosage* / Q000633:toxicity; D007111:Immunity, Cellular / Q000187:drug effects; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D008297:Male; D008546:Melanoma, Experimental / Q000276:immunology* / Q000473:pathology* / Q000503:physiopathology; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D013154:Spleen / Q000276:immunology / Q000378:metabolism
D000928:Antidepressive Agents; D016207:Cytokines; D005473:Fluoxetine; D003891:Desipramine