Rare case of disseminated neonatal zygomycosis mimicking necrotizing enterocolitis with necrotizing fasciitis.
A set of monochorionic male twins presented with intestinal perforation. The smaller twin was diagnosed with necrotizing enterocolitis followed by sepsis, disseminated intravascular coagulation, and necrotizing fasciitis of the abdominal wall. The infant died on the fourth day after surgery, 16 days after birth. Surgical specimens and autopsy revealed a disseminated zygomycotic infection. Gastrointestinal zygomycosis followed by necrotizing fasciitis in premature infants is a rare condition and mimics necrotizing enterocolitis clinically. Necrotizing fasciitis after gastrointestinal zygomycosis in premature infants is considered a poor prognostic sign. Gastrointestinal zygomycosis should be considered in the differential diagnosis of necrotizing enterocolitis.
Department of Hepato-Billiary-Pancreatic and Pediatric Surgery, Saitama Medical Center, Saitama Medical University, Kamoda 1981, Kawagoe, Saitama, 3508550, Japan. sei_khsr@saitama-med.ac.jp
Seiichiro
S
Inoue
Akio
A
Odaka
Daijo
D
Hashimoto
Reiichi
R
Hoshi
Clara
C
Kurishima
Tetsuya
T
Kunikata
Hisanori
H
Sobajima
Masanori
M
Tamura
Junichi
J
Tamaru
D034861:Abdominal Wall / Q000382:microbiology / Q000473:pathology*; D003108:Colonic Diseases / Q000150:complications / Q000151:congenital; D057210:Delayed Diagnosis; D003951:Diagnostic Errors; D013505:Digestive System Surgical Procedures; D004200:Diseases in Twins; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D020345:Enterocolitis, Necrotizing / Q000175:diagnosis* / Q000601:surgery; D019115:Fasciitis, Necrotizing / Q000209:etiology* / Q000601:surgery; D017809:Fatal Outcome; D005317:Fetal Growth Retardation; D005734:Gangrene; D006801:Humans; D007077:Ileal Diseases / Q000151:congenital / Q000601:surgery; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000175:diagnosis* / Q000382:microbiology / Q000601:surgery; D007416:Intestinal Perforation / Q000150:complications / Q000151:congenital / Q000601:surgery; D008297:Male; D012127:Respiratory Distress Syndrome, Newborn / Q000150:complications; D020096:Zygomycosis / Q000150:complications / Q000151:congenital / Q000175:diagnosis* / Q000601:surgery