Screening adulteration of polypropylene bottles with postconsumer recycled plastics for oral drug package by near-infrared spectroscopy.
Adulteration of pharmaceutical packaging containers with postconsumer recycled plastic materials was considerably difficult to identify due to the similar chemical compositions of virgin and recycled plastics. In the present study, near-infrared (NIR) spectroscopy coupled with conformity test was proposed to screen the adulteration of pharmaceutical packaging containers. Two kinds of representative screening models were investigated on polypropylene (PP) bottles for oral drug package. The reliability of the screening models was validated through studying the identification reliability, specificity, and robustness of the methods. The minimum spiking level of two modeled adulterants at the proportion of 20% could be detected, and the unqualified sample from a domestic manufacturer was rejected by this developed method. This strategy represents a rapid and promising analytical method for screening the adulteration of pharmaceutical plastic packaging containers with postconsumer recycled plastics.
Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China.
Lan-Gui
LG
Xie
Hui-Min
HM
Sun
Shao-Hong
SH
Jin
D000284:Administration, Oral; D002152:Calorimetry, Differential Scanning; D004349:Drug Packaging / Q000379:methods*; D005240:Feasibility Studies; D005607:Fraud / Q000517:prevention & control*; D011126:Polypropylenes / Q000032:analysis* / Q000737:chemistry*; D059027:Recycling; D015203:Reproducibility of Results; D013055:Spectrophotometry, Infrared / Q000379:methods*; D013997:Time Factors
D011126:Polypropylenes