Nuclear factor kappa B (NF-κB): a novel cause for diabetes, coronary artery disease and cancer initiation and promotion?
Obesity is a growing epidemic in the United States (US). Obesity has been recognized as a modifiable risk factor for many diverse diseases including diabetes, cardiovascular disease and cancer burden. Common contributors to obesity include a high fat diet, smoking and physical inactivity. Systemic effects of obesity include increased micro-inflammatory molecules such as nuclear factor kappa B (NF-κB) that influence the both endothelial and epithelial layers as well as the supportive stroma. An emerging risk factor for micro-inflammation also includes periodontal disease. These pro-inflammatory states are hypothesized to contribute to diabetes as well as cardiovascular disease and cancer through the direct activation of NF-κB. Therefore, a comprehensive health care strategy would include reduction of diabetes, cardiovascular and cancer risk through the decrease in micro-inflammation.
University of Arizona, Department of Internal Medicine, Tucson, AZ 85724, USA. nsrial@email.arizona.edu
Nathaniel S
NS
Rial
Kwan
K
Choi
Tam
T
Nguyen
Branden
B
Snyder
Marvin J
MJ
Slepian
D015992:Body Mass Index; D003324:Coronary Artery Disease / Q000209:etiology* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000378:metabolism*; D008954:Models, Biological; D016328:NF-kappa B / Q000378:metabolism*; D009369:Neoplasms / Q000209:etiology* / Q000378:metabolism; D009765:Obesity / Q000150:complications*; D010510:Periodontal Diseases / Q000150:complications; D012307:Risk Factors
D016328:NF-kappa B