Neutrophil dynamics in response to chemotherapy and G-CSF.
We have used a mathematical model of the combined dynamics of the hematopoietic stem cells and the differentiated neutrophil progeny to examine the effects of periodic chemotherapy in generating neutropenia, and the corresponding response of this system to granulocyte colony stimulating factor given to counteract the neutropenia. We find that there is a significant period of chemotherapy delivery that induces resonance in the system (at a period twice the average neutrophil lifespan from commitment to death) and a corresponding neutropenia suggesting that myelosuppressive protocols should avoid this period to minimize hematopoietic damage. The response to G-CSF is highly variable.
Zhou Pei-Yuan Center for Applied Mathematics, Tsinghua University, Beijing 100084, China.
Changjing
C
Zhuge
Jinzhi
J
Lei
Michael C
MC
Mackey
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004334:Drug Administration Schedule; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000473:pathology; D006801:Humans; D008954:Models, Biological; D009503:Neutropenia / Q000139:chemically induced / Q000517:prevention & control; D009504:Neutrophils / Q000187:drug effects* / Q000473:pathology
D000970:Antineoplastic Agents; D016179:Granulocyte Colony-Stimulating Factor