Polymorphisms of transforming growth factor-β signaling pathway and Kawasaki disease in the Taiwanese population.
Kawasaki disease (KD) is a systemic vasculitis associated with cardiovascular symptom. A previous study in the European descent has indicated that genetic variants of the transforming growth factor-β (TGF-β) pathway are involved in the KD susceptibility and clinical status. This study was conducted to investigate if polymorphisms in TGF-β signaling pathway are associated with KD susceptibility, and the coronary artery lesion formation. A total of 950 subjects (381 KD patients and 569 controls) were investigated to identify 12 single-nucleotide polymorphisms in the TGF-β signaling pathway (rs2796817, rs10482751, rs2027567, rs12029576, rs11466480, rs4776338, rs12901071, rs7162912, rs1438386, rs6494633, rs12910698 and rs4776339) by using TaqMan Allelic Discrimination assay. Our results indicated that rs1438386 in the SMAD3 is significantly associated with the susceptibility of KD. Additionally, both haplotypes of TGFβ2 and SMAD3 were also associated with the risk of KD. This study showed that genetic polymorphisms in TGF-β signaling pathway are associated with KD susceptibility, but not coronary artery lesions formation, or intravenous immunoglobulin treatment response in the Taiwanese population.
Division of Allergy, Immunology and Rheumatology, Department of Pedatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Ho-Chang
HC
Kuo
Yoshihiro
Y
Onouchi
Yu-Wen
YW
Hsu
Wei-Chiao
WC
Chen
Jin-Ding
JD
Huang
Ying-Hsien
YH
Huang
Ya-Ling
YL
Yang
Mei-Chyn
MC
Chao
Hong-Ren
HR
Yu
Yung-Shun
YS
Juan
Chiu-Ming
CM
Kuo
Kuender D
KD
Yang
Jung-San
JS
Huang
Wei-Chiao
WC
Chang
D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003331:Coronary Vessels / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D009080:Mucocutaneous Lymph Node Syndrome / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D018125:Receptors, Transforming Growth Factor beta / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics*; D051900:Smad3 Protein / Q000235:genetics; D013624:Taiwan; D016212:Transforming Growth Factor beta / Q000235:genetics*; D055815:Young Adult
D018125:Receptors, Transforming Growth Factor beta; D051900:Smad3 Protein; D016212:Transforming Growth Factor beta