Pro-inflammatory and vasoconstricting prostanoid PGF2α causes no headache in man.
BACKGROUND
During two decades of migraine provocation studies with naturally occurring signalling molecules, vasodilators such as prostaglandin E(2), prostaglandin I(2) (prostacyclin) and prostaglandin D(2) were shown to be able to induce headache in man. To elucidate the role of inflammation and vasodilatation in the generation of headache, we investigated whether the pro-inflammatory and vasoconstricting prostanoid prostaglandin F(2α) (PGF(2α)) would cause headache in a human model of headache.


METHODS
Twelve healthy volunteers were randomly allocated to receive 3.5 µg/kg/min PGF(2α) or placebo over 20 min in a two-way crossover study. We recorded headache intensity on a verbal rating scale, middle cerebral artery blood flow velocity (V(MCA)) and the diameters of the superficial temporal artery (STA) and radial artery (RA).


RESULTS
We found no difference in the area under the curve (AUC) for immediate headache (0-90 min) between PGF(2α) and placebo (p = 0.144). The McNemar's test showed no difference in the incidence of immediate and delayed headache between verum and placebo (p = 0.500 and p = 1.000, respectively). There was no difference in V(MCA) (p = 0.776) and in the diameter of the STA (p = 0.460) or RA (p = 0.780) between PGF(2α) and placebo.


CONCLUSIONS
The present study shows that PGF(2α), unlike vasodilating prostaglandins, does not provoke headache. We suggest that the vasodilating abilities of prostaglandins are important for the induction of experimental headache in healthy volunteers.
University of Copenhagen, Denmark.
Maria
M
Antonova
Troels
T
Wienecke
Jes
J
Olesen
Messoud
M
Ashina
D000328:Adult; D001158:Arteries / Q000187:drug effects* / Q000503:physiopathology*; D018592:Cross-Over Studies; D015237:Dinoprost / Q000633:toxicity*; D005260:Female; D006261:Headache / Q000139:chemically induced* / Q000503:physiopathology*; D006801:Humans; D018836:Inflammation Mediators / Q000633:toxicity; D008297:Male; D014662:Vasoconstrictor Agents / Q000633:toxicity; D055815:Young Adult
D018836:Inflammation Mediators; D014662:Vasoconstrictor Agents; D015237:Dinoprost