Design of a photoswitchable hollow microcapsular drug delivery system by using a supramolecular drug-loading approach.
In this study, photoswitchable microcapsules were fabricated based on host-guest interactions between α-cyclodextrin (α-CD) and azobenzene (Azo). Carboxymethyl dextran-graft-α-CD (CMD-g-α-CD) and poly(acrylic acid) N-aminododecane p-azobenzeneaminosuccinic acid (PAA-C(12)-Azo) were assembled layer by layer on CaCO(3) particles. α-CD-rhodamine B (α-CD-RhB), used as a model drug, was loaded on PAA-C(12)-Azo layers by host-guest interaction. After removal of CaCO(3) particles by ethylenediaminetetraacetic acid (EDTA), hollow microcapsules loaded with α-CD-RhB were obtained. Since the interactions between α-CD and Azo were photosensitive, the capsules could be dissociated with the irradiation of UV light, followed by the release of the model drug, α-CD-RhB. Compared with traditional drug-loading approaches such as chemical bonding and physical adsorption, our supramolecular drug-loading system has a facile loading process, ideal bonding strength, and photoswitchable behavior. These photosensitive microcapsules exhibit great potential in biomedical applications.
Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, People's Republic of China.
Wang
W
Xiao
Wei-Hai
WH
Chen
Jing
J
Zhang
Cao
C
Li
Ren-Xi
RX
Zhuo
Xian-Zheng
XZ
Zhang
D000180:Acrylic Resins / Q000737:chemistry; D001391:Azo Compounds / Q000737:chemistry*; D002119:Calcium Carbonate / Q000737:chemistry; D002214:Capsules / Q000737:chemistry*; D003911:Dextrans / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D010782:Photolysis; D012235:Rhodamines / Q000138:chemical synthesis / Q000737:chemistry*; D014466:Ultraviolet Rays; D047391:alpha-Cyclodextrins / Q000737:chemistry
D000180:Acrylic Resins; D001391:Azo Compounds; D002214:Capsules; D003911:Dextrans; D004337:Drug Carriers; D012235:Rhodamines; D047391:alpha-Cyclodextrins; C006903:carbopol 940; C014392:carboxymethyl dextran; C009850:azobenzene; D002119:Calcium Carbonate; C032613:alpha-cyclodextrin