Tongue cancers during pregnancy: Case reports and review of literature.
BACKGROUND
Due to its rarity, there is no standard treatment for tongue cancers that concur with pregnancy. Treatment depends on the stage of cancer, gestational age of the pregnancy, and the wish of the mother to maintain the pregnancy. The purpose of this study was to review the literature and to report 5 new cases.


METHODS
Twelve cases of tongue cancer during pregnancy were already reported between 1987 and 2009. We report 5 new cases and first administration of concomitant radiochemotherapy for tongue cancer.


RESULTS
Median age of the patients was 29 years, 65% of diagnoses were made after the first trimester of pregnancy. Different treatment modalities are used to treat tongue cancer during pregnancy.


CONCLUSIONS
We hypothesize that tongue cancer treatment adhering to standard protocols provides the best guarantee to cure the mother. Based on a growing experience and insight taking fetal safety into consideration, the available data suggest that standard treatment is a realistic option.
Department of Obstetrics and Gynecology, Division Gynecologic Oncology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium.
Mina
M
Mhallem Gziri
Sileny N
SN
Han
Kristel
K
Van Calsteren
Liesbeth
L
Heyns
Pierre
P
Delaere
Sandra
S
Nuyts
Frank
F
Van den Heuvel
Anne-Céline
AC
Cheron
Eric
E
Fossion
Danielle
D
Van den Weyngaert
Christianne
C
Lok
Frédéric
F
Amant
D000328:Adult; D059248:Chemoradiotherapy; D005260:Female; D006801:Humans; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis / Q000628:therapy*; D014059:Tongue / Q000473:pathology*; D014062:Tongue Neoplasms / Q000175:diagnosis / Q000628:therapy*; D016896:Treatment Outcome