Advances in metal-carbene complexes as potent anti-cancer agents.
This critical review is an updated survey of metal-carbenes as potential anticancer chemotherapeutics. We report on the recent advances in the discovery of N-heterocyclic carbenes, acyclic diamino carbenes and abnormal NHCs associated with metals from groups 10 and 11 that displayed antiproliferative activity and emphasize, when possible, their molecular target(s) and their mechanism of action.
CNRS, UMR 6504, F-63177 Aubière, CEDEX, France. Arnaud.Gautier@univ-bpclermont.fr
Arnaud
A
Gautier
Federico
F
Cisnetti
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000627:therapeutic use*; D002460:Cell Line; D056831:Coordination Complexes / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry; D006801:Humans; D008670:Metals / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D009369:Neoplasms / Q000737:chemistry*
D000970:Antineoplastic Agents; D056831:Coordination Complexes; D006571:Heterocyclic Compounds; D008670:Metals; C030011:carbene; D008697:Methane