Sarcoid-related uveitis occurring during adalimumab therapy.
OBJECTIVE
To report the first case of sarcoid-related uveitis in a patient receiving adalimumab.


METHODS
Case report.


METHODS
A 61-year-old woman with rheumatoid arthritis treated with adalimumab for 4 years presented with a 1-year history of bilateral panuveitis with venous vasculitis and peripheral multifocal choroiditis. A small papular lesion was found on her forehead, which upon biopsy showed noncaseating granulomas. No systemic involvement was observed.


RESULTS
An ophtalmological and clinical improvement was seen after (TNF) antagonist withdrawal plus a course of prednisone.


CONCLUSIONS
Ophthalmologists should know that a sarcoid-like granulomatosis can develop during TNFα blockade therapy.
Pascal
P
Seve
Loig
L
Varron
Christiane
C
Broussolle
Philippe
P
Denis
Laurent
L
Kodjikian
D000068879:Adalimumab; D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects* / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009887:Ophthalmoscopy; D012507:Sarcoidosis / Q000139:chemically induced* / Q000175:diagnosis; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D015866:Uveitis, Posterior / Q000139:chemically induced* / Q000175:diagnosis
D061067:Antibodies, Monoclonal, Humanized; D018501:Antirheumatic Agents; D014409:Tumor Necrosis Factor-alpha; D000068879:Adalimumab