Diet and the risk of head and neck cancer: a pooled analysis in the INHANCE consortium.
We investigated the association between diet and head and neck cancer (HNC) risk using data from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. The INHANCE pooled data included 22 case-control studies with 14,520 cases and 22,737 controls. Center-specific quartiles among the controls were used for food groups, and frequencies per week were used for single food items. A dietary pattern score combining high fruit and vegetable intake and low red meat intake was created. Odds ratios (OR) and 95% confidence intervals (CI) for the dietary items on the risk of HNC were estimated with a two-stage random-effects logistic regression model. An inverse association was observed for higher-frequency intake of fruit (4th vs. 1st quartile OR = 0.52, 95% CI = 0.43-0.62, p (trend) < 0.01) and vegetables (OR = 0.66, 95% CI = 0.49-0.90, p (trend) = 0.01). Intake of red meat (OR = 1.40, 95% CI = 1.13-1.74, p (trend) = 0.13) and processed meat (OR = 1.37, 95% CI = 1.14-1.65, p (trend) < 0.01) was positively associated with HNC risk. Higher dietary pattern scores, reflecting high fruit/vegetable and low red meat intake, were associated with reduced HNC risk (per score increment OR = 0.90, 95% CI = 0.84-0.97).
Imperial College London, London, UK.
Shu-Chun
SC
Chuang
Mazda
M
Jenab
Julia E
JE
Heck
Cristina
C
Bosetti
Renato
R
Talamini
Keitaro
K
Matsuo
Xavier
X
Castellsague
Silvia
S
Franceschi
Rolando
R
Herrero
Deborah M
DM
Winn
Carlo
C
La Vecchia
Hal
H
Morgenstern
Zuo-Feng
ZF
Zhang
Fabio
F
Levi
Luigino
L
Dal Maso
Karl
K
Kelsey
Michael D
MD
McClean
Thomas
T
Vaughan
Philip
P
Lazarus
Joshua
J
Muscat
Heribert
H
Ramroth
Chu
C
Chen
Stephen M
SM
Schwartz
Jose
J
Eluf-Neto
Richard B
RB
Hayes
Mark
M
Purdue
Stefania
S
Boccia
Gabriella
G
Cadoni
David
D
Zaridze
Sergio
S
Koifman
Maria Paula
MP
Curado
Wolfgang
W
Ahrens
Simone
S
Benhamou
Elena
E
Matos
Pagona
P
Lagiou
Neonilla
N
Szeszenia-Dabrowska
Andrew F
AF
Olshan
Leticia
L
Fernandez
Ana
A
Menezes
Antonio
A
Agudo
Alexander W
AW
Daudt
Franco
F
Merletti
Gary J
GJ
Macfarlane
Kristina
K
Kjaerheim
Dana
D
Mates
Ivana
I
Holcatova
Stimson
S
Schantz
Guo-Pei
GP
Yu
Lorenzo
L
Simonato
Hermann
H
Brenner
Heiko
H
Mueller
David I
DI
Conway
Peter
P
Thomson
Eleonora
E
Fabianova
Ariana
A
Znaor
Peter
P
Rudnai
Claire M
CM
Healy
Gilles
G
Ferro
Paul
P
Brennan
Paolo
P
Boffetta
Mia
M
Hashibe
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004032:Diet / Q000009:adverse effects / Q000706:statistics & numerical data*; D005260:Female; D006258:Head and Neck Neoplasms / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors