How focal adhesion kinase achieves regulation by linking ligand binding, localization and action.
Focal adhesion kinase (FAK) has an astonishing number of ligands and functions, which enable it to contribute to embryonic development and human health. FAK can promote different effects in similar cellular environments or similar effects in different cellular environments. Recent advances in structural and cellular analysis of FAK are starting to reveal the interrelationships between the conformations, localizations, interactions, and functions of FAK. This review focuses on our emerging understanding of how the structural framework of FAK mechanistically allows it to integrate manifold stimuli into environment-specific functions.
Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. starold@mdanderson.org
Stefan T
ST
Arold
D001665:Binding Sites; D051416:Focal Adhesion Protein-Tyrosine Kinases / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D008954:Models, Biological; D008958:Models, Molecular; D011485:Protein Binding
D008024:Ligands; D051416:Focal Adhesion Protein-Tyrosine Kinases