Comparative study on the efficacy of tiotropium bromide inhalation and oral doxofylline treatment of moderate to severe stable chronic obstructive pulmonary disease.
This study compared the efficacy and safety of tiotropium bromide inhalation powder (spiriva) and doxofylline oral tablet (doxofylline) in the treatment of chronic obstructive pulmonary disease (COPD). A multi-center, randomized, double-blind, double-dummy, parallel-controlled study involved 127 eligible stable moderate to severe COPD patients treated with inhaled tiotropium dry powder (18 μg/day) or oral doxofylline tablets (0.2 g/time, 2 times a day) for 12 and 24 weeks. Before and after treatment for 12 weeks and 24 weeks, respectively, pulmonary function, 6-min walking distance and dyspnea index were recorded. The results showed that in both tiotropium group and doxofylline groups, after 12-week treatment, FEV(1), FEV(1)/FVC% and 6-min walk distance were significantly higher than those before the medication, while dyspnea index decreased as compared with that before treatment. After 24-week treatment, a slight improvement in the measures was observed as compared with that of 12-weeks treatment, but the difference was not statistically significant. With both 12-week and 24-week treatment, the effect of tiotropium was slightly better than that of doxofylline tablets, with the difference being statistically insignificant. The major adverse events in the tiotropium group and doxofylline group were observed in 9 cases (9.9%) and 12 cases (12.9%), respectively, and no statistically significant difference was found between them. We are led to conclude that both tiotropium at 18 μg a day and doxofylline tablets at 0.2 g/day (two times a day) are effective and safe for the treatment of COPD.
Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong Science and Technology University, Wuhan, 430030, China.
Tao
T
Wang
Department of Respiratory Medicine, Wuhan First Hospital, Wuhan, 430022, China.
Guangwei
G
Luo
Department of Respiratory Medicine, Wuhan Second Hospital, Wuhan, 430014, China.
Yi
Y
Hu
Department of Respiratory Medicine, Wuhan Sixth Hospital, Wuhan, 430015, China.
Fajiu
F
Li
Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong Science and Technology University, Wuhan, 430030, China.
Jing
J
Ma
Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong Science and Technology University, Wuhan, 430030, China.
Jianmiao
J
Wang
Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong Science and Technology University, Wuhan, 430030, China.
Peng
P
Zuo
Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong Science and Technology University, Wuhan, 430030, China.
Weining
W
Xiong
Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong Science and Technology University, Wuhan, 430030, China.
Xiansheng
X
Liu
Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong Science and Technology University, Wuhan, 430030, China.
Jianping
J
Zhao
Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong Science and Technology University, Wuhan, 430030, China.
Shengdao
S
Xiong
Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong Science and Technology University, Wuhan, 430030, China.
Zhenxiang
Z
Zhang
Department of Respiratory Medicine, Wuhan Sixth Hospital, Wuhan, 430015, China.
Chenghong
C
Li
Department of Respiratory Medicine, Wuhan Second Hospital, Wuhan, 430014, China.
Su
S
Zhao
Department of Respiratory Medicine, Wuhan First Hospital, Wuhan, 430022, China.
Jiemin
J
Sun
Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong Science and Technology University, Wuhan, 430030, China. yjxu@tjh.tjmu.edu.cn.
Yongjian
Y
Xu
D000280:Administration, Inhalation; D000368:Aged; D000369:Aged, 80 and over; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy*; D012129:Respiratory Function Tests; D012602:Scopolamine Derivatives / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013806:Theophylline / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000069447:Tiotropium Bromide
D001993:Bronchodilator Agents; D012602:Scopolamine Derivatives; D013806:Theophylline; C029797:doxofylline; D000069447:Tiotropium Bromide