Common variants on 8p12 and 1q24.2 confer risk of schizophrenia.
Schizophrenia is a severe mental disorder affecting ∼1% of the world population, with heritability of up to 80%. To identify new common genetic risk factors, we performed a genome-wide association study (GWAS) in the Han Chinese population. The discovery sample set consisted of 3,750 individuals with schizophrenia and 6,468 healthy controls (1,578 cases and 1,592 controls from northern Han Chinese, 1,238 cases and 2,856 controls from central Han Chinese, and 934 cases and 2,020 controls from the southern Han Chinese). We further analyzed the strongest association signals in an additional independent cohort of 4,383 cases and 4,539 controls from the Han Chinese population. Meta-analysis identified common SNPs that associated with schizophrenia with genome-wide significance on 8p12 (rs16887244, P = 1.27 × 10(-10)) and 1q24.2 (rs10489202, P = 9.50 × 10(-9)). Our findings provide new insights into the pathogenesis of schizophrenia.
Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, China. shiyongyong@gmail.com
Yongyong
Y
Shi
Zhiqiang
Z
Li
Qi
Q
Xu
Ti
T
Wang
Tao
T
Li
Jiawei
J
Shen
Fengyu
F
Zhang
Jianhua
J
Chen
Guoquan
G
Zhou
Weidong
W
Ji
Baojie
B
Li
Yifeng
Y
Xu
Dengtang
D
Liu
Peng
P
Wang
Ping
P
Yang
Benxiu
B
Liu
Wensheng
W
Sun
Chunling
C
Wan
Shengying
S
Qin
Guang
G
He
Stacy
S
Steinberg
Sven
S
Cichon
Thomas
T
Werge
Engilbert
E
Sigurdsson
Sarah
S
Tosato
Aarno
A
Palotie
Markus M
MM
Nöthen
Marcella
M
Rietschel
Roel A
RA
Ophoff
David A
DA
Collier
Dan
D
Rujescu
David St
DS
Clair
Hreinn
H
Stefansson
Kari
K
Stefansson
Jue
J
Ji
Qingzhong
Q
Wang
Wenjin
W
Li
Linqing
L
Zheng
Hairong
H
Zhang
Guoyin
G
Feng
Lin
L
He
D000328:Adult; D000368:Aged; D044466:Asian People; D016022:Case-Control Studies; D002878:Chromosomes, Human, Pair 1; D002898:Chromosomes, Human, Pair 8; D005260:Female; D056426:Genetic Loci; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D025341:Principal Component Analysis; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics*; D055815:Young Adult