Orienting fate: spatial regulation of neurogenic divisions.
Cleavage plane orientation has been thought to govern the fate of neural stem cell progeny, but supporting evidence in the neocortex has been sparse. A new study by Postiglione et al. in this issue of Neuron shows that mouse Inscuteable-mediated control of cleavage plane orientation regulates the output of neural progenitor cells.
Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, 35 Medical Center Way, San Francisco, CA 94143, USA.
Xiaoqun
X
Wang
Jan H
JH
Lui
Arnold R
AR
Kriegstein
D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism*; D019070:Cell Lineage / Q000502:physiology*; D016764:Cell Polarity / Q000502:physiology*; D019579:Neocortex / Q000254:growth & development*; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000378:metabolism*; D008941:Spindle Apparatus / Q000378:metabolism*
D018797:Cell Cycle Proteins; C561632:inscuteable protein, mouse