Determination of triclosan in antiperspirant gels by first-order derivative spectrophotometry.
A first-order derivative UV spectrophotometric method was developed to determine triclosan, a broad-spectrum antimicrobial agent, in health care products containing fragrances which could interfere the determination as impurities. Different extraction methods were compared. Triclosan was extracted with chloroform and diluted with ethanol followed by the derivative spectrophotometric measurement. The interference of fragrances was completely eliminated. The calibration graph was found to be linear in the range of 7.5-45 microg x mL(-1). The method is simple, rapid, sensitive and proper to determine triclosan in fragrance-containing health care products.
Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, China.
Lina
L
Du
Miao
M
Li
Yiguang
Y
Jin
D000891:Anti-Infective Agents, Local / Q000032:analysis*; D051520:Antiperspirants / Q000032:analysis*; D002138:Calibration; D005782:Gels; D006863:Hydrogen-Ion Concentration; D012996:Solutions; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet; D014260:Triclosan / Q000032:analysis*
D000891:Anti-Infective Agents, Local; D051520:Antiperspirants; D005782:Gels; D012996:Solutions; D012997:Solvents; D014260:Triclosan