The effect of pneumoperitoneum on haemodynamic parameters in morbidly obese patients.
BACKGROUND
The type of anaesthetic used affects the cardiovascular function in morbidly obese patients during pneumoperitoneum. In this prospective randomized study, we evaluated the influence of inhalation anaesthesia with sevoflurane or intravenous anaesthesia with propofol on haemodynamic performance in obese patients during laparoscopy.


METHODS
Patients scheduled for laparoscopic bariatric procedures were randomly divided into two groups: sevoflurane (group S) or propofol (group P). Haemodynamic function was measured using the transoesophageal Doppler method after induction of anaesthesia (T₁), insuflation of CO₂ (T₂) and in the anti-Trendelenburg position with pneumoperitoneum (T₃).


RESULTS
One hundred patients were enrolled in the study. The demographic data did not differ between the groups. At T₂, the blood flow parameters and ventricle ejection parameters decreased in both groups whereas the systemic vascular resistance and mean arterial pressure increased. The heart rate was stable. At T₃, afterload parameters and heart rate increased in both groups yet blood flow parameters decreased in group P. The changes observed were not accompanied by any serious clinical signs of cardiovascular deterioration.


CONCLUSIONS
Pneumoperitoneum has an important negative impact on haemodynamic function in morbidly obese patients but those changes are not accompanied by severe cardiovascular disturbances. Volatile anaesthesia provides better haemodynamic stability during laparoscopic bariatric surgery in such patients.
Department of Anaesthesiology and Intensive Therapy, Medical University of Łódź, Medical University of Lodz. tomgaszyn@poczta.onet.pl
Tomasz
T
Gaszynski
D000328:Adult; D000771:Anesthesia, Intravenous / Q000379:methods*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D050110:Bariatric Surgery / Q000009:adverse effects / Q000379:methods*; D001784:Blood Gas Analysis / Q000379:methods; D005260:Female; D006439:Hemodynamics; D006801:Humans; D010535:Laparoscopy / Q000379:methods; D008297:Male; D008738:Methyl Ethers; D008875:Middle Aged; D009767:Obesity, Morbid / Q000503:physiopathology* / Q000601:surgery*; D011028:Pneumoperitoneum, Artificial / Q000009:adverse effects*; D015742:Propofol; D011446:Prospective Studies; D000077149:Sevoflurane
D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D015742:Propofol