Comparative pharmacokinetic studies of peimine and peiminine in rat plasma by LC-MS-MS after oral administration of Fritillaria thunbergii Miq. and Fritillaria thunbergii Miq. - Glycyrrhiza uralensis Fisch. couple extract.
A sensitive LC-MS-MS method has been successfully applied to pharmacokinetic study of peimine and peiminine in rat plasma after oral administration of Fritillaria thunbergii Miq. exact and Fritillaria thunbergii Miq. - Glycyrrhiza uralensis Fisch. couple extract. The results indicated that plasma profiles of peimine and peiminine confirmed to two-compartment open model with weighting function of 1/C2 for data fitting and parameter estimation and the utilization with Glycyrrhiza uralensis Fisch. could decrease C(max) and prolong MRT(0-infinity) and t1/2 of peimine remarkly with the bioavailability of peimine remained practically unchanged. Meanwhile, the concentration of peimine in rat plasma was more stable. Nevertheless, there were no significant differences among all calculated parameters of peiminine.
Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of TCM, Nanchang, China.
Lihua
L
Chen
Lili
L
Liu
Weifeng
W
Zhu
Huimin
H
Zhang
Zhihong
Z
Yan
Hongning
H
Liu
D000818:Animals; D000996:Antitussive Agents / Q000097:blood / Q000493:pharmacokinetics*; D002138:Calibration; D002595:Cevanes / Q000097:blood / Q000493:pharmacokinetics*; D002853:Chromatography, Liquid; D005260:Female; D031410:Fritillaria / Q000737:chemistry*; D006035:Glycyrrhiza / Q000737:chemistry*; D007202:Indicators and Reagents; D013058:Mass Spectrometry; D010936:Plant Extracts / Q000737:chemistry; D011786:Quality Control; D051381:Rats; D017207:Rats, Sprague-Dawley; D012015:Reference Standards; D015203:Reproducibility of Results
D000996:Antitussive Agents; D002595:Cevanes; D007202:Indicators and Reagents; D010936:Plant Extracts; C014242:verticine; C047331:peiminine