RAIDDing ER stress for oncolytic viral therapy.
Oncolytic viruses exploit molecular differences between normal and cancer cells to selectively kill the latter. Results of a synthetic lethal screen described in this issue of Cancer Cell demonstrate that components of the unfolded protein response (UPR) limit virus-induced tumor cell killing and identify a strategy to utilize this knowledge.
Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. dmcconke@mdanderson.org
David J
DJ
McConkey