IL-17 response mediates acute lung injury induced by the 2009 pandemic influenza A (H1N1) virus.
The 2009 flu pandemic involved the emergence of a new strain of a swine-origin H1N1 influenza virus (S-OIV H1N1) that infected almost every country in the world. Most infections resulted in respiratory illness and some severe cases resulted in acute lung injury. In this report, we are the first to describe a mouse model of S-OIV virus infection with acute lung injury and immune responses that reflect human clinical disease. The clinical efficacy of the antiviral oseltamivir (Tamiflu) administered in the early stages of S-OIV H1N1 infection was confirmed in the mouse model. Moreover, elevated levels of IL-17, Th-17 mediators and IL-17-responsive cytokines were found in serum samples of S-OIV-infected patients in Beijing. IL-17 deficiency or treatment with monoclonal antibodies against IL-17-ameliorated acute lung injury induced by the S-OIV H1N1 virus in mice. These results suggest that IL-17 plays an important role in S-OIV-induced acute lung injury and that monoclonal antibodies against IL-17 could be useful as a potential therapeutic remedy for future S-OIV H1N1 pandemics.
State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Center of Translational Medicine, Peking Union Medical College, Tsinghua University, Beijing 100005, China.
Chenggang
C
Li
Penghui
P
Yang
Yang
Y
Sun
Taisheng
T
Li
Chen
C
Wang
Zhong
Z
Wang
Zhen
Z
Zou
Yiwu
Y
Yan
Wei
W
Wang
Chen
C
Wang
Zhongwei
Z
Chen
Li
L
Xing
Chong
C
Tang
Xiangwu
X
Ju
Feng
F
Guo
Jiejie
J
Deng
Yan
Y
Zhao
Peng
P
Yang
Jun
J
Tang
Huanling
H
Wang
Zhongpeng
Z
Zhao
Zhinan
Z
Yin
Bin
B
Cao
Xiliang
X
Wang
Chengyu
C
Jiang
D000208:Acute Disease; D000818:Animals; D001835:Body Weight; D004195:Disease Models, Animal; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000472:pathogenicity*; D007251:Influenza, Human / Q000821:virology*; D020381:Interleukin-17 / Q000172:deficiency / Q000276:immunology*; D007700:Kinetics; D055370:Lung Injury / Q000276:immunology* / Q000473:pathology* / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D058873:Pandemics; D015996:Survival Rate
D020381:Interleukin-17