A new eudesmane sesquiterpene glucoside from Liriope muscari fibrous roots.
The screening of several Chinese medicinal herbs for nematocidal properties showed that the ethanol extract of Liriope muscari fibrous roots possessed significant nematocidal activity against the pine wood nematode (Bursaphelenchus xylophilus). From the ethanol extract, a new constituent (1,4-epoxy-cis-eudesm-6-O-β-D-glucopyranoside) and three known glycosides [1β,6α-dihydroxy-cis-eudesm-3-ene-6-O-β-D-glucopyranoside (liriopeoside A), 1β,6β-dihydroxy-cis-eudesm-3-ene-6-O-β-D-glucopyranoside, and 1α,6β-dihydroxy-5,10-bis-epi-eudesm-4(15)-ene-6-O-β D-glucopyranoside] were isolated by bioassay-guided fractionation. The structures were elucidated by 1D and 2D NMR and MS techniques. 1,4-Epoxy-cis-eudesm-6-O-β-D-glucopyranoside possessed moderate nemato-cidal activity against B. xylophilus with a LC(50 )value of 339.76 μg/mL, while liriopeoside A (LC(50) = 82.84 μg/mL) and 1β,6β-dihydroxy-cis-eudesm-3-ene-6-O-β-D-glucopyranoside (LC(50) = 153.39 μg/mL) also exhibited nematocidal activity against B. xylophilus. The crude extract of L. muscari fibrous roots exhibited nematocidal activity against the pine wood nematode with a LC(50) value of 182.56 μg/mL.
State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Beijing 100875, China.
Hai Ming
HM
Zhang
Gang Li
GL
Wang
Chun Qi
CQ
Bai
Peng
P
Liu
Zi Mu
ZM
Liu
Qi Zhi
QZ
Liu
Yong Yan
YY
Wang
Zhi Long
ZL
Liu
Shu Shan
SS
Du
Zhi Wei
ZW
Deng
D000818:Animals; D000969:Antinematodal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031424:Liriope Plant / Q000033:anatomy & histology / Q000737:chemistry*; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D009348:Nematoda / Q000187:drug effects; D028223:Pinus / Q000469:parasitology; D018517:Plant Roots / Q000737:chemistry*; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000969:Antinematodal Agents; D005960:Glucosides; D045787:Sesquiterpenes, Eudesmane