Macrophages and neutrophils in SLE-An online molecular catalog.
Systemic Lupus Erythematosus (SLE) is a heterogeneous group of autoimmune disorders defined by a consensus of clinical and laboratory criteria. Much of the pathophysiology and therapy of SLE has focused on autoimmune B and T cells of the adaptive immune system. Recently, focus has shifted to the role of myeloid cells like neutrophils and macrophages - part of the innate immune system - in SLE pathogenesis. These cells have altered molecular profiles affecting multiple pathways, but no salient overview has been undertaken to broadly define and categorize this dysregualtion. Here we endeavor to provide this overview and build a new freely accessible online resource for this purpose (http://www.mohanlab.org/SLE_BASE/myeloid_cells/).
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, 75390, USA.
Jacob
J
Orme
Chandra
C
Mohan
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002377:Catalogs as Topic; D002448:Cell Adhesion / Q000276:immunology; D002634:Chemotaxis, Leukocyte / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D006801:Humans; D018836:Inflammation Mediators / Q000276:immunology; D020407:Internet; D008180:Lupus Erythematosus, Systemic / Q000276:immunology* / Q000378:metabolism; D008262:Macrophage Activation / Q000276:immunology; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism; D018375:Neutrophil Activation / Q000276:immunology; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism; D010587:Phagocytosis / Q000276:immunology
D016207:Cytokines; D018836:Inflammation Mediators