Aortic valve calcification in mild primary hyperparathyroidism.
BACKGROUND
It is unclear whether cardiovascular disease is present in primary hyperparathyroidism (PHPT).


OBJECTIVE
Aortic valve structure and function were compared in PHPT patients and population-based controls.


METHODS
This is a case-control study.


METHODS
The study was conducted in a university hospital metabolic bone disease unit.


METHODS
We studied 51 patients with PHPT and 49 controls.


METHODS
We measured the aortic valve calcification area and the transaortic pressure gradient.


RESULTS
Aortic valve calcification area was significantly higher in PHPT (0.24 ± 0.02 vs. 0.17 ± 0.02 cm(2), p<0.01), although there was no difference in the peak transaortic pressure gradient, a functional measure of valvular calcification (5.6 ± 0.3 vs. 6.0 ± 0.3 mm Hg, P = 0.39). Aortic valve calcification area was positively associated with PTH (r = 0.34; P < 0.05) but not with serum calcium, phosphorus, or 25-hydroxyvitamin D levels or with calcium-phosphate product. Serum PTH level remained an independent predictor of aortic valve calcification area after adjustment for age, sex, body mass index, smoking status, history of hypercholesterolemia and hypertension, and estimated glomerular filtration rate.


CONCLUSIONS
Mild PHPT is associated with subclinical aortic valve calcification. PTH, but not serum calcium concentration, predicted aortic valve calcification. PTH was a more important predictor of aortic valve calcification than well-accepted cardiovascular risk factors.
Department of Medicine, Columbia University, New York, New York 10032, USA.
Shinichi
S
Iwata
Marcella Donovan
MD
Walker
Marco R
MR
Di Tullio
Eiichi
E
Hyodo
Zhezhen
Z
Jin
Rui
R
Liu
Ralph L
RL
Sacco
Shunichi
S
Homma
Shonni J
SJ
Silverberg
D000368:Aged; D001021:Aortic Valve / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D002114:Calcinosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D009202:Cardiomyopathies / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D016022:Case-Control Studies; D004452:Echocardiography / Q000379:methods; D005260:Female; D006305:Health Status Indicators; D006349:Heart Valve Diseases / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000378:metabolism
D008903:Minerals