Incidence and human papillomavirus (HPV) type distribution of genital warts in a multinational cohort of men: the HPV in men study.
BACKGROUND
Data on the natural history of human papillomavirus (HPV)-related genital warts (GWs) in men are sparse. We described the distribution of HPV types in incident GWs and estimated GW incidence and time from type-specific incident HPV infections to GW detection in a multinational cohort of men aged 18-70 years.


METHODS
Participants included 2487 men examined for GWs and tested for HPV every 6 months and followed up for a median of 17.9 months. Samples were taken from 112 men with incident GWs to test for HPV DNA by polymerase chain reaction.


RESULTS
Incidence of GWs was 2.35 cases per 1000 person-years, with highest incidence among men aged 18-30 years (3.43 cases per 1000 person-years). HPV 6 (43.8%), HPV 11 (10.7%), and HPV 16 (9.8%) were the genotypes most commonly detected in GWs. The 24-month cumulative incidence of GWs among men with incident HPV 6/11 infections was 14.6% (95% confidence interval [CI], 7.5%-21.1%). Median time to GW detection was 17.1 months (95% CI, 12.4-19.3 months), with shortest time to detection among men with incident infections with HPV 6/11 only (6.2 months; 95% CI, 5.6-24.2 months).


CONCLUSIONS
HPV 6/11 plays an important role in GW development, with the highest incidence and shortest time to detection among men with incident HPV 6/11 infection.
Department of Cancer Epidemiology, Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA. anna.giuliano@moffitt.or
Gabriella M
GM
Anic
Ji-Hyun
JH
Lee
Heather
H
Stockwell
Dana E
DE
Rollison
Yougui
Y
Wu
Mary R
MR
Papenfuss
Luisa L
LL
Villa
Eduardo
E
Lazcano-Ponce
Christine
C
Gage
Roberto José C
RJ
Silva
Maria L
ML
Baggio
Manuel
M
Quiterio
Jorge
J
Salmerón
Martha
M
Abrahamsen
Anna R
AR
Giuliano
D000293:Adolescent; D000328:Adult; D000368:Aged; D003218:Condylomata Acuminata / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis*; D005838:Genotype; D052140:Human papillomavirus 11 / Q000302:isolation & purification*; D052162:Human papillomavirus 16 / Q000302:isolation & purification*; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D010409:Penile Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology*; D015995:Prevalence; D013997:Time Factors; D055815:Young Adult
D004279:DNA, Viral