Analysis of matrix metalloproteinase-1 gene polymorphisms and expression in benign and malignant breast tumors.
A guanine insertion polymorphism in matrix metalloproteinase-1 promoter (MMP-1 2G) is linked to early onset and aggressiveness in cancer. We determined the role of MMP-1 2G on MMP-1 expression and breast cancer severity in patients with breast diseases. We observed no significant difference in genotype distribution among different disease groups. However, MMP-1 expression was significantly higher in atypical ductal hyperplasia than in benign breast disease and in invasive breast cancer compared to in situ breast cancer. MMP-1 2G insertion polymorphism in the invasive group also correlated significantly with the expression of MMP-1 and breast cancer prognostic markers HER2 and P53.
Clinical Breast Care Project, Windber Research Institute, Windber, Pennsylvania, PA 15963, USA.
Jing
J
Zhou
Constance
C
Brinckerhoff
Susan
S
Lubert
Kui
K
Yang
Jasmine
J
Saini
Jeffrey
J
Hooke
Richard
R
Mural
Craig
C
Shriver
Stella
S
Somiari
D000368:Aged; D001943:Breast Neoplasms / Q000201:enzymology* / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D007150:Immunohistochemistry; D020781:Matrix Metalloproteinase 1 / Q000096:biosynthesis* / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis
D020781:Matrix Metalloproteinase 1; D018719:Erb-b2 Receptor Tyrosine Kinases; D016159:Tumor Suppressor Protein p53; C495901:TP53 protein, human