Clear cell, papillary and chromophobe renal cell carcinoma in patients younger than 20 years old: a clinicopathologic study with follow-up.
OBJECTIVE
To perform a clinicopathologic study with follow-up on this rare subset of tumors in the pediatric population.


METHODS
A search was made through the surgical pathology files of two academic institutions for cases of non-translocation associated renal cell carcinoma in patients younger than 20 years old from 1995 to 2011.


RESULTS
12 cases were identified from 350 pediatric patients with renal tumors (prevalence = 3.4%). The mean age at diagnosis was 11 years (range 1-18 years). The average tumor size was 7.3 cm (range 3.0-15.0 cm). Pathological staging analysis revealed 7/12 (58%) pT1 tumors, 3/12 (25%) pT2 tumors, and 2/12 (17%) pT3 tumors. Lymph node metastasis was present in 3/12 (25%) patients. The majority of tumors 9/12 (75%) were Fuhrman nuclear grade 2, while 3/12 (25%) cases were Fuhrman nuclear grade 3. Tumor necrosis was identified in 5/12 (42%) tumors, and angiolymphatic invasion was identified in 4/12 (33%) tumors; 1 patient developed lung metastasis.


CONCLUSIONS
Pathologic parameters typically associated with poor outcome in adults, including metastasis/high tumor stage, high Fuhrman nuclear grade, angiolymphatic invasion, and tumor necrosis, did not lead to death in any of the patients in our series.
Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Jason
J
Wang
Bahig M
BM
Shehata
Simone M
SM
Langness
Gigi K
GK
Davis
Liang
L
Cheng
Adeboye O
AO
Osunkoya
D018262:Adenocarcinoma, Clear Cell / Q000453:epidemiology / Q000473:pathology*; D000231:Adenocarcinoma, Papillary / Q000453:epidemiology / Q000473:pathology*; D000293:Adolescent; D002292:Carcinoma, Renal Cell / Q000453:epidemiology / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000453:epidemiology / Q000473:pathology*; D008297:Male; D009367:Neoplasm Staging; D015995:Prevalence; D012189:Retrospective Studies; D014481:United States / Q000453:epidemiology