[Effects of eight environmental endocrine disruptors on insulin resistance in patients with polycystic ovary syndrome: a preliminary investigation].
OBJECTIVE
To investigate the relationship between 8 endocrine-disrupting chemicals in the serum and insulin resistance in patients with polycystic ovary syndrome (PCOS).


METHODS
This study was conducted among 60 patients with PCOS, including 23 with insulin resistance (PCOS-IR) and 37 without insulin resistance (PCOS-NIR), and 29 non-PCOS women seeking medical attention for infertility or menstrual disorder (control group). The serum levels of 6 phthalic acid esters (PEAs), bisphenol A (BPA) and octylphenol (OP) were measured in all the subjects.


RESULTS
The levels of PAEs, BPA and OP showed no significant differences between PCOS patients and the control group (P>0.05). The serum level of OP was significantly lower in patients PCOS-IR than in those with PCOS-NIR (47.89 ng/ml vs 60.24 ng/ml, P<0.05).


CONCLUSIONS
PEAs and BPA do not produce obvious effect on the pathogenesis of PCOS or contribute to insulin resistance, but OP may play a role in insulin resistance in PCOS patients.
Department of Obstetrics and Gynecology, Sichuan University, Chengdu, China. aki-yo@163.com
Ting-ting
TT
Li
Liang-zhi
LZ
Xu
Yong-heng
YH
Chen
Hong-mei
HM
Deng
Chun-ying
CY
Liang
Ying
Y
Liu
Xiao-fang
XF
Liu
Jing
J
Zhang
De-ying
DY
Kang
Dong-sheng
DS
Qiu
Dai-wen
DW
Han
Rong
R
Hu
D000328:Adult; D001559:Benzhydryl Compounds / Q000009:adverse effects / Q000097:blood; D016022:Case-Control Studies; D052244:Endocrine Disruptors / Q000009:adverse effects* / Q000097:blood*; D004785:Environmental Pollutants / Q000009:adverse effects / Q000097:blood; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D010636:Phenols / Q000009:adverse effects / Q000097:blood; D010795:Phthalic Acids / Q000009:adverse effects / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000503:physiopathology; D055815:Young Adult; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D010636:Phenols; D010795:Phthalic Acids; C474055:octylphenol; C027387:di-n-hexyl phthalate; C006780:bisphenol A; D000098826:Bisphenol A Compounds; C007379:diethyl phthalate