Acute cortical necrosis following renal transplantation in a case of sickle cell trait.
Renal transplant recipients who have sickle cell disease are at risk of infection, recurrent graft disease, and sickling crisis that affects the long-term outcome. We report a patient of sickle cell trait who developed patchy cortical necrosis in the perioperative period but had a good long-term outcome. The renal cortical necrosis was presumed to be secondary to cyclosporine-basiliximab interaction in the backdrop of sickling trait. The patient additionally had spontaneous closure of vascular access and severe hypertension immediately following transplantation suggestive of vaso-occlusive crisis. Cyclosporine and basiliximab drug interaction needs to be recognized and steps need to be taken in patients to avoid perioperative graft dysfunction.
Department of Nephrology and Urology, Medwin Hospital, Hyderabad, India.
S
S
Shiradhonkar
R
R
Jha
B S
BS
Rao
G
G
Narayan
S
S
Sinha
G
G
Swarnalata