Aptamer-conjugated nanomaterials and their applications.
The combination of aptamers with novel nanomaterials, including nanomaterial-based aptamer bioconjugates has attracted considerable interest and has led to a wide variety of applications. In this review, we discuss how a variety of nanomaterials, including gold, silica and magnetic nanoparticles, as well as carbon nanotubes, hydrogels, liposomes and micelles, have been used to functionalize aptamers for a variety of applications. These aptamer functionalized materials have led to advances in amplified biosensing, cancer cell-specific recognition, high-efficiency separation, and targeted drug delivery.
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan University, Changsha, PR China.
Liu
L
Yang
Xiaobing
X
Zhang
Mao
M
Ye
Jianhui
J
Jiang
Ronghua
R
Yang
Ting
T
Fu
Yan
Y
Chen
Kemin
K
Wang
Chen
C
Liu
Weihong
W
Tan
D000818:Animals; D052157:Aptamers, Nucleotide / Q000008:administration & dosage* / Q000737:chemistry / Q000235:genetics; D015374:Biosensing Techniques; D002460:Cell Line; D004337:Drug Carriers / Q000737:chemistry*; D006046:Gold / Q000737:chemistry; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry
D052157:Aptamers, Nucleotide; D004337:Drug Carriers; D020100:Hydrogels; D006046:Gold; D012822:Silicon Dioxide