Histidinylated linear PEI: a new efficient non-toxic polymer for gene transfer.
A series of linear polyethylenimine (lPEI) substituted with histidine residue (His-lPEI) was synthesized using the Michael reaction in order to provide new highly efficient vectors for gene therapy applications (up to 95% of transfected cells) with remarkable low cytotoxicity compared to lPEI-based polyplexes.
Laboratoire LAMBE équipe MPI, UMR 8587, Université d'Evry Val d'Essonne, Evry, France.
Emilie
E
Bertrand
Cristine
C
Gonçalves
Ludivine
L
Billiet
Jean Pierre
JP
Gomez
Chantal
C
Pichon
Hervé
H
Cheradame
Patrick
P
Midoux
Philippe
P
Guégan
D004337:Drug Carriers / Q000737:chemistry* / Q000633:toxicity; D057809:HEK293 Cells; D006367:HeLa Cells; D006639:Histidine / Q000737:chemistry*; D006801:Humans; D011094:Polyethyleneimine / Q000737:chemistry* / Q000633:toxicity; D014162:Transfection / Q000379:methods*
D004337:Drug Carriers; D006639:Histidine; D011094:Polyethyleneimine