RPL36 as a prognostic marker in hepatocellular carcinoma.
Ribosomal proteins (RP) play key roles in the regulation of apoptosis, multidrug resistance and carcinogenesis. The aim of this study was to investigate the expression of ribosomal protein L36 (RPL36) in hepatocellular carcinoma (HCC) and to correlate it with clinicopathological parameters and clinical outcome. Liver specimens were obtained from 60 HCC patients who had undergone a partial hepatectomy. Expression of RPL36 in tumor tissue and surrounding non-tumorous tissues was evaluated on a tissue microarray by immunohistochemistry. RPL36 was expressed in 45 of 60 (75%) HCC by immunohistochemistry, but was not detected in corresponding non-tumors. RPL36 expression correlated significantly with serum levels of albumin (P= 0.044) and prothrombin time (P= 0.026), which reflect liver synthetic function. Moreover, expression of RPL36 was found to be higher in patients with early tumor stages (I/II) (P= 0.038) or without portal vein thrombosis (P= 0.005). In univariate analysis, patients with RPL36 expression revealed better overall survival (P= 0.037). By multivariate survival analysis, RPL36 expression was found to be an independent prognostic factor for overall survival (P= 0.026). Our data suggest that RPL36 may be involved in the early stage of hepatocarcinogenesis, and it can be used as an independent and potential prognostic marker for resected HCC.
Hepatology and Gastroenterology and WHO Collaborating Center of Viral Hepatitis, The Catholic University of Korea, Seoul, Korea.
Myeong Jun
MJ
Song
Chan Kwon
CK
Jung
Chung-Hwa
CH
Park
Wonhee
W
Hur
Jung Eun
JE
Choi
Si Hyun
SH
Bae
Jong Young
JY
Choi
Sang Wook
SW
Choi
Nam Ik
NI
Han
Seung Kew
SK
Yoon
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D045744:Cell Line, Tumor; D003710:Demography; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006498:Hepatectomy; D006801:Humans; D008099:Liver / Q000378:metabolism; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D008297:Male; D051379:Mice; D008875:Middle Aged; D011379:Prognosis; D012008:Recurrence; D012269:Ribosomal Proteins / Q000235:genetics / Q000378:metabolism*; D016019:Survival Analysis
D014408:Biomarkers, Tumor; C489129:RPL36A protein, human; D012269:Ribosomal Proteins