[Botulinum toxine treatment and the formation of antibodies to botulotoxin in patients with cerebral palsy].
The aim of the study was to search for the association between efficacy of botulinum treatment (dysport) and the formation of antibodies to botulinum toxin in children with cerebral palsy (CP). Fourteen children with CP received dysport, 42 children (29 with CP and 13 patients with paresises of other etiologies) were not treated with this drug. No association between the presence of antibodies in blood serum and efficacy of treatment was found. However, further research of the role of antibody genesis as a factor influencing the formation of reaction to treatment is needed.
V M
VM
Kenis
A G
AG
Baindurashvili
A G
AG
Dovbeshko
T N
TN
Korol'kova
A M
AM
Ivanov
Iu A
IuA
Stepanova
O V
OV
Protasov
D000293:Adolescent; D000907:Antibodies, Bacterial / Q000097:blood*; D019274:Botulinum Toxins, Type A / Q000276:immunology* / Q000627:therapeutic use*; D002547:Cerebral Palsy / Q000097:blood / Q000188:drug therapy* / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male
D000907:Antibodies, Bacterial; D019274:Botulinum Toxins, Type A; C542869:abobotulinumtoxinA