Autophagy in pulmonary diseases.
(Macro)autophagy provides a membrane-dependent mechanism for the sequestration, transport, and lysosomal turnover of subcellular components, including proteins and organelles. In this capacity, autophagy maintains basal cellular homeostasis and healthy organelle populations such as mitochondria. During starvation, autophagy prolongs cell survival by recycling metabolic precursors from intracellular macromolecules. Furthermore, autophagy represents an inducible response to chemical and physical cellular stress. Increasing evidence suggests that autophagy, and its regulatory proteins, may critically influence vital cellular processes such as programmed cell death, cell proliferation, inflammation, and innate immune functions and thereby may play a critical role in the pathogenesis of human disease. The function of autophagy in disease pathogenesis remains unclear and may involve either impaired or accelerated autophagic activity or imbalances in the activation of autophagic proteins. This review examines the roles of autophagy in the pathogenesis of pulmonary diseases, with emphasis on pulmonary vascular disease and acute and chronic lung diseases.
Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. sryter@partners.org
Stefan W
SW
Ryter
Kiichi
K
Nakahira
Jeffrey A
JA
Haspel
Augustine M K
AM
Choi
D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D001343:Autophagy / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D001808:Blood Vessels / Q000503:physiopathology; D003550:Cystic Fibrosis / Q000473:pathology; D004646:Emphysema / Q000473:pathology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000473:pathology; D000860:Hypoxia / Q000503:physiopathology; D007113:Immunity, Innate / Q000502:physiology; D007249:Inflammation / Q000503:physiopathology; D008171:Lung Diseases / Q000503:physiopathology*; D011652:Pulmonary Circulation / Q000502:physiology; D029424:Pulmonary Disease, Chronic Obstructive / Q000473:pathology; D012907:Smoking / Q000473:pathology