[Chemical constituents from the roots of Pithecellobium lucidum and their cytotoxic activity].
Six compounds were isolated from the roots of Pithecellobium lucidum by various chromatograhic techniques such as column chromatography on silica gel and Sephadex LH-20, and preparative HPLC, and their structures were elucidated as julibroside A2 (1), 3-[ (2-acetamido-2-deoxy-beta-D-glucopyranosyl) oxy] -16alpha-hydroxyolean-12-en-28-oic acid (2), galloyl acid (3), ethyl gallate (4), (+)-catechin (5), (-)-gallocatechin gallate (6) on the basis of spectrascopic data analysis. Compounds 1-6 were isolated from Pithecellobium lucidum for the first time. Compound 2 showed selective cytoxic activity against the human cell lines A2780 with an IC50 value of 1.72 micromol x L(-1).
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing 100050, China.
Shuanggang
S
Ma
Haining
H
Lv
Guangzhi
G
Ding
Shishan
S
Yu
Xiaoguang
X
Chen
D002392:Catechin / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D002460:Cell Line; D007887:Fabaceae / Q000737:chemistry*; D005707:Gallic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D006801:Humans; D020128:Inhibitory Concentration 50; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification; D010936:Plant Extracts / Q000737:chemistry* / Q000633:toxicity; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity
C584930:3-((2-acetamido-2-deoxy-beta-D-glucopyranosyl)oxy) -16alpha-hydroxyolean-12-en-28-oic acid; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; C584929:julibroside A2; C417940:gallocatechin gallate; C048734:ethyl gallate; D005707:Gallic Acid; D009828:Oleanolic Acid; D002392:Catechin