Some inflammatory cytokine levels, iron metabolism and oxidan stress markers in subjects with nonalcoholic steatohepatitis.
OBJECTIVE
The relation between nonalcoholic steatohepatitis and iron metabolism is still controversial. Free fatty acids, iron, and other sources of oxidative stress probably result in cell damage, and necroinflammation mediated by various cytokines.


METHODS
Sixty patients were diagnosed with NASH were included in the study, and the patient group was divided into three subgroups. Iron metabolism markers, inflammatory cytokines, including TNF-α, IL-6 and IL-8, MDA and nitric oxide levels were measured.


RESULTS
Serum ferritin, inflammatory cytokines, and oxidative stress markers were significantly higher in the patient group. Among three patient groups, divided according to the results of ultrasonic examination, there were significant changes with regard to these parameters.


CONCLUSIONS
The study results suggest that liver iron and fat accumulation, oxidant stres, and inflammatory cytokines are closely related. Therefore, levels of serum ferritin, MDA, IL-6, TNF-α and IL-8 could represent the indices of activity and progression of NASH.
Fatih University Medical Faculty, Department of Biochemistry, Turkey.
Sema
S
Uysal
Ferah
F
Armutcu
Timucin
T
Aydogan
Kayihan
K
Akin
Mustafa
M
Ikizek
M Ramazan
MR
Yigitoglu
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D023181:Antimicrobial Cationic Peptides / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D005234:Fatty Liver / Q000097:blood* / Q000000981:diagnostic imaging; D005260:Female; D005293:Ferritins / Q000097:blood; D064451:Hepcidins; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D007501:Iron / Q000097:blood*; D008099:Liver / Q000000981:diagnostic imaging; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D065626:Non-alcoholic Fatty Liver Disease; D018384:Oxidative Stress; D014463:Ultrasonography
D023181:Antimicrobial Cationic Peptides; D015415:Biomarkers; D016207:Cytokines; D064451:Hepcidins; D018836:Inflammation Mediators; D009569:Nitric Oxide; D008315:Malondialdehyde; D005293:Ferritins; D007501:Iron; D000410:Alanine Transaminase