Association of IL-10-1082 G/G genotype with lower mortality of acute respiratory distress syndrome in a Chinese population.
We aimed to investigate whether interleukin-10 (IL-10) -1082 G/G genotype is associated with lower mortality of acute respiratory distress syndrome (ARDS) in a Chinese population. A hospital-based case-control study was conducted in 314 cases of ARDS and 210 controls who were admitted to an intensive care unit with sepsis, trauma, aspiration or massive transfusions. Cases were followed for 30-day mortality. The -1082G/G genotype was associated with lower development of ARDS (OR=0.51; 95% CI 0.34-0.76; P=0.001). Among patients with ARDS, the -1082G/G genotype was associated with lower 30-day mortality (OR=0.44; 95% CI 0.25-0.76; P=0.003). In conclusion, IL-10-1082 G/G genotype is associated with lower development and mortality of ARDS in a Chinese population.
Intensive Care Unit, West China Hospital, Sichuan University, 37 Guo Xue Road, Chengdu, 610041, Sichuan, China. xdjin2010@hotmail.com
Xiaodong
X
Jin
Zhi
Z
Hu
Yan
Y
Kang
Chang
C
Liu
Yongfang
Y
Zhou
Xiaodong
X
Wu
Jin
J
Liu
Mingxing
M
Zhong
Chuanxing
C
Luo
Lijing
L
Deng
Yiyun
Y
Deng
Xiaoqi
X
Xie
Zhongwei
Z
Zhang
Yan
Y
Zhou
Xuelian
X
Liao
D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D017931:DNA Primers / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D012128:Respiratory Distress Syndrome / Q000235:genetics* / Q000401:mortality*
D017931:DNA Primers; C508609:IL10 protein, human; D016753:Interleukin-10