The assessment of lipid peroxidation products and the activity of superoxide dismutase in patients with heart failure.
The study concerns determination of disturbances of the oxidative-antioxidative balance in patients with heart failure. The study group consisted of 37 patients, having the average age of 42.3 +/- 12.3 years, suffering from idiopathic or inflammatory heart failure. The patients have been qualified as degree II/III in accordance with NYHA scale. A statistically significant increase of anty-oxLDL level (254.28 +/- 80.79 vs 196.64 +/- 83.11 mU/ml; p<0.01) and malondialdehyde level (4.86 +/- 1.74 vs 3.71 +/- 1.19 micromol/l; p<0.05) has been demonstrated after 6-month observation. No statistically significant differences have been found for the activity of total superoxide dismutase (SOD) and its isoenzymes--(SOD-Mn) and (SOD-ZnCu). The results of the study indicate that no changes in SOD activity and increase in lipid peroxidation products level may lead to generation of oxidative stress may play an important role in the pathogenesis of heart failure.
Zakład Biochemii Ogólnej, Katedra Biochemii w Zabrzu Slaskiego Uniwersytetu Medycznego w Katowicach. eromuk@gmail.com
Ewa
E
Romuk
Wojciech
W
Jacheć
Bronisława
B
Skrzep-Poloczek
Celina
C
Wojciechowska
Kamil
K
Kurza
Agnieszka
A
Wróblewska
Marta
M
Cwieczek
Ewa
E
Birkner
D000328:Adult; D002374:Catalase / Q000378:metabolism; D005260:Female; D006333:Heart Failure / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D008077:Lipoproteins, LDL / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000378:metabolism*
D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase