Biochemistry and biology of the inducible multifunctional transcription factor TFII-I: 10 years later.
Exactly twenty years ago TFII-I was discovered as a biochemical entity that was able to bind to and function via a core promoter element called the Initiator (Inr). Since then several different properties of this signal-induced multifunctional factor were discovered. Here I update these ever expanding functions of TFII-I--focusing primarily on the last ten years since the first review appeared in this journal.
Department of Pathology, Sackler School of Biomedical Sciences, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA. ananda.roy@tufts.ed
Ananda L
AL
Roy
D002453:Cell Cycle; D049109:Cell Proliferation; D015658:HIV Infections / Q000378:metabolism; D006801:Humans; D018919:Neovascularization, Physiologic; D011401:Promoter Regions, Genetic; D015398:Signal Transduction; D019473:Transcription Factors, TFII / Q000737:chemistry* / Q000378:metabolism*; D014158:Transcription, Genetic; D018980:Williams Syndrome / Q000378:metabolism
D019473:Transcription Factors, TFII