[A case of status epilepticus with a possible therapeutic effect by dantrolene sodium].
We report a 62-year-old man who have taken major tranquilizer for schizophrenia for the past 24 years. He had sudden generalized tonic-clonic seizure and consciousness loss on April 2010. He was administered diazepam, phenytoin, phenobarbital intravenously and drip-infused with midazolam continuously, but the seizure persisted. For a possible comorbidity of neuroleptic malignant syndrome, we administered dantrolene sodium intravenously and bromocriptine through a nasal gastric tube. The refractory status epilepticus disappeared immediately after the administration. Status epilepticus remitted 2 days later but again disappeared with repeated injection of dantrolene. These results suggested that intravenous administration of dantrolene may have alleviated the refractory symptoms of status epilepticus.
Department of the Internal Medicine, Tohyama Hospital.
Atsunori
A
Hiasa
Ryogen
R
Sasaki
Toshiaki
T
Takeuchi
Hidekazu
H
Tomimoto
D003620:Dantrolene / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009125:Muscle Relaxants, Central / Q000627:therapeutic use*; D013226:Status Epilepticus / Q000188:drug therapy*
D009125:Muscle Relaxants, Central; D003620:Dantrolene