[Biomechanical research of SOX9, CTGF in bone tendon junction healing].
OBJECTIVE
To investigate the biomechanical effect of SOX9, CTGF in bone tendon junction healing.


METHODS
36 adult New Zealand rabbits were randomly divided into A, B and C groups(each group were 12 rab-bits). Group A with SOX9 inject into bone tendon junction;Group B with CTGF inject into bone tendon junction; C group was inject nothing. The animal of three groups were used surgery and all of the animals were faced with biomechanical test after 4 weeks, 8 weeks and 12 weeks; The result were used statistical analysis.


RESULTS
group A and group B's cross-sectional area were lower than group C during 4 weeks, 12 weeks postoperative; there were statistical difference between each groups ( P < 0. 05). group Aand group B's pulled off load and ultimate tensile stress were higher than group C during 4 weeks, 8 weeks, 12 weeks postoperative, the result were statistical difference between each groups ( P < 0. 05).


CONCLUSIONS
SOX9 and CTGF group can not only promote the early bone ten-don junction healing, But also increased the biomechanical strength of bone tendon junction.
Southern Medical Hospital, Southern Medical University, Guangzhou, China.
Zhi-qi
ZQ
Zhu
Jian-min
JM
Jiang
Yan-kui
YK
Leng
Dong-ling
DL
Cai
D000818:Animals; D001696:Biomechanical Phenomena / Q000187:drug effects; D055513:Connective Tissue Growth Factor / Q000494:pharmacology*; D055595:Mechanical Phenomena; D011817:Rabbits; D055758:SOX9 Transcription Factor / Q000494:pharmacology*; D013314:Stress, Mechanical; D013710:Tendons / Q000187:drug effects* / Q000502:physiology* / Q000601:surgery; D013718:Tensile Strength / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects*
D055758:SOX9 Transcription Factor; D055513:Connective Tissue Growth Factor