A multi-component domino reaction for the direct access to polyfunctionalized indoles via intermolecular allylic esterification and indolation.
A novel multi-component reaction for the synthesis of polyfunctionalized indoles and bis-indoles has been established. The reaction pathways were controlled by varying enamines with different substitution patterns to give polyfunctionalized indoles and bis-indoles selectively. The reaction proceeds at a fast speed within 15-30 min with water as the major byproduct, which makes work-up convenient.
School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Xuzhou Normal University, PR China.
Bo
B
Jiang
Mian-Shuai
MS
Yi
Feng
F
Shi
Shu-Jiang
SJ
Tu
Suresh
S
Pindi
Patrick
P
McDowell
Guigen
G
Li
D000588:Amines / Q000737:chemistry*; D004951:Esterification; D007211:Indoles / Q000138:chemical synthesis*; D008872:Microwaves
D000588:Amines; D007211:Indoles