Formulation and development of taste masked fast-disintegrating tablets (FDTs) of Chlorpheniramine maleate using ion-exchange resins.
BACKGROUND
Masking of bitter taste of drug for better patient compliance.


OBJECTIVE
The objective of this research was to mask the bitter taste of Chlorpheniramine maleate using cation exchange resins.


METHODS
Different cation exchange resins were used for taste masking. The drug resin complexes (DRC) were prepared by batch process. Complexes of ion-exchange resin and Chlorpheniramine maleate were prepared by taking drug: resin ratios 1:1, 1:2, 1:3 and 1:4 (w/w). The optimum drug:resin ratio and the time required for maximum complexation was determined. The drug resinates were evaluated for the drug content, taste, drug release, FTIR, DSC and X-ray diffraction (PXRD).


CONCLUSIONS
The X-ray diffraction study confirmed the monomolecularity of entrapped drug in the resin beads. The taste evaluation depicted the successful taste masking of Chlorpheniramine maleate with DRCs. Fast disintegrating tablets (FDTs) were developed depending upon percent complexation, release study at salivary and gastric pH, taste evaluation; Chlorpheniramine maleate: Indion-234 complex of ratio 1:2 was used to develop and formulate FDTs. The drug release of 94.77% in 30 min was observed from FDTs.


CONCLUSIONS
The Effective taste masking can be obtained from DRC that can be formulated as FDTs for better patient compliance.
Department of Pharmaceutics, MVP Samaj's College of Pharmacy, Shivajinagar, Gangapur Road, Nashik, Maharashtra, India. chetanyewale99@gmail.com
Chetan P
CP
Yewale
Mohan N
MN
Rathi
Girish G
GG
Kore
Ganesh V
GV
Jadhav
Milind P
MP
Wagh
D002626:Chemistry, Pharmaceutical / Q000379:methods; D002744:Chlorpheniramine / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007475:Ion Exchange Resins / Q000737:chemistry*; D013607:Tablets / Q000737:chemistry; D013649:Taste; D014961:X-Ray Diffraction / Q000379:methods
D007475:Ion Exchange Resins; D013607:Tablets; D002744:Chlorpheniramine