[Systemic amyloidoses].
Amyloidoses are rare protein folding disorders, in which proteins are deposited as insoluble fibrillar aggregates due to a conformational change. This can occur in a local or systemic form. Systemic amyloidoses are life-threatening complications of monoclonal gammopathy, chronic inflammatory diseases or within hereditary diseases. The causative treatment of amyloidosis is the reduction of the amyloid precursor protein by chemotherapy, anti-inflammatory treatment, or liver transplantation. Early diagnosis of the disease is essential in order to effectively treat patients and avoid further deterioration of organ functions.
Amyloidose-Zentrum, Universitätsklinikum Heidelberg, Heidelberg, Deutschland. stefan.schoenland@med.uni-heidelberg.de
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Schönland
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D000686:Amyloidosis / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D010265:Paraproteinemias / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*