[Perioperative adverse events related to antidepressive agents use].
OBJECTIVE
Depression is the most common psychiatric disease, which is treated by the use of antidepressive agents possessing various mechanisms of action. Thus, the use in preoperative period of antidepressive agents is frequent (7% of patients scheduled for surgery). The objective of this review was to update the knowledge on the drug interactions between antidepressive agents and drugs used in perioperative period.


METHODS
(i) Medline and Ovid databases using combination of antidepressive agent and perioperative period as keywords; (ii) national and European epidemiologic database; (iii) expert recommendation and official French health agency; (iv) reference book chapters.


RESULTS
The clinical practice showed a limited risk of adverse event related to antidepressant agents interaction with perioperative used drugs. In the two past decades, few relevant observations of adverse event related with imipramine and monoamine oxidase inhibitors use was reported. The most recent antidepressive agents had no serious adverse interaction. Nevertheless, the serotonin syndrome has to be known as far as it is more and more reported. In case of hypotension, the use of vasopressive agent has to be careful because of excessive response.
Service d'anesthésie et de réanimation chirurgicale, hôpital G.-et-R.-Laënnec, CHU de Nantes, boulevard Jacques-Monod, 44093 Nantes cedex 1, France.
B
B
Rozec
R
R
Cinotti
Y
Y
Blanloeil
D000777:Anesthetics / Q000009:adverse effects; D000928:Antidepressive Agents / Q000009:adverse effects*; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects; D004347:Drug Interactions; D005060:Europe; D005602:France; D006801:Humans; D007431:Intraoperative Complications / Q000139:chemically induced*; D008996:Monoamine Oxidase Inhibitors / Q000009:adverse effects; D010275:Parasympathetic Nervous System / Q000187:drug effects; D059035:Perioperative Period; D011183:Postoperative Complications / Q000139:chemically induced*; D012306:Risk; D012701:Serotonin / Q000502:physiology; D020230:Serotonin Syndrome / Q000150:complications; D013375:Substance Withdrawal Syndrome / Q000150:complications / Q000523:psychology
D000777:Anesthetics; D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic; D008996:Monoamine Oxidase Inhibitors; D012701:Serotonin