Unilateral tacrolimus-associated optic neuropathy after liver transplantation.
BACKGROUND
Tacrolimus has been associated with several ocular adverse effects, such as optic neuropathy.


RESULTS
A 56-year-old woman noted sudden, severe, painless visual loss in her left eye. She had undergone liver transplantation for alcoholic related cirrhosis 6 months before. Her chronic immunosuppressive regimen consisted of prednisone and tacrolimus at dosage of 1.5 mg orally once daily. Consequently, the patient developed a left optic neuropathy.


CONCLUSIONS
We report the first case of unilateral optic neuropathy associated with oral tacrolimus medication. Surgeons and ophthalmologists must evaluate ocular symptoms in the post-transplantation period, and suspicion should be maintained even if unilaterality or asymmetry of symptoms against a toxic etiology.
Department of Ophthalmology, Lozano Blesa University Clinic Hospital, Zaragoza, Spain. jascaso@gmail.com
Francisco J
FJ
Ascaso
Javier
J
Mateo
Valentin
V
Huerva
José A
JA
Cristóbal
D001766:Blindness / Q000139:chemically induced / Q000175:diagnosis; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016031:Liver Transplantation; D008875:Middle Aged; D009901:Optic Nerve Diseases / Q000139:chemically induced* / Q000175:diagnosis; D016559:Tacrolimus / Q000009:adverse effects*; D041623:Tomography, Optical Coherence
D007166:Immunosuppressive Agents; D016559:Tacrolimus