Cancer incidence and pattern of arsenic concentration in drinking water wells in Córdoba, Argentina.
Cancer occurrence is associated with Arsenic (As) in drinking water. In Argentina, there are high As concentrations in groundwater but there is no published evidence yet of an association between geographic patterns of cancer incidence and the distribution of As in groundwater supplies. The purpose of this study is to assess the association between cancer incidence patterns and As in Córdoba province's aquifers. Age standardized incidence rates (ASIRs) were obtained from Córdoba Cancer Registry (CCR), and As data from official reports of monitoring wells. A multilevel model was applied. Total ASIRs by aquifers for males/females were 191.01/249.22 (Rioja plain); 215.03/225.37 (Pampa hills); and 239.42/188.93 (Chaco-Pampa plain). As was associated with increased risk of colon cancer in women, and lung and bladder cancers in both sexes. It had no association with breast cancer. ASIRs were related to As, controlling for unobserved heterogeneity. An overlapping pattern of higher As and higher risks was evident for lung, bladder and female colon cancers.
School of Nutrition, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Enrique Barros esq. Enfermera Gordillo, Ciudad Universitaria, Córdoba, 5000, Argentina.
Laura Rosana
LR
Aballay
María del Pilar
Mdel P
Díaz
Franco Matías
FM
Francisca
Sonia Edith
SE
Muñoz
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001118:Argentina / Q000453:epidemiology; D001151:Arsenic / Q000032:analysis / Q000633:toxicity; D002648:Child; D002675:Child, Preschool; D060766:Drinking Water / Q000032:analysis* / Q000592:standards; D004784:Environmental Monitoring / Q000706:statistics & numerical data; D062665:Epidemiological Monitoring; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology* / Q000209:etiology; D012042:Registries; D012737:Sex Factors; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000633:toxicity; D060986:Water Wells / Q000032:analysis* / Q000592:standards; D055815:Young Adult
D060766:Drinking Water; D014874:Water Pollutants, Chemical; D001151:Arsenic