Cellular biochemistry of the multifunctional transglutaminase 2: challenging issues and novel concepts.
The transglutaminase TG2 can do a lot more than just transamidation: it has multiple biochemical activities, appears in various cell compartments, and has been implicated in a broad range of cellular processes and pathologies. Decades after its discovery, this enigmatic protein still intrigues researchers. Some of the most recent and compelling findings concerning TG2 are reviewed in four minireivews in this issue of FEBS Journal.
Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary.
László
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Fésüs
D000588:Amines / Q000378:metabolism; D002118:Calcium / Q000502:physiology; D002467:Cell Nucleus / Q000201:enzymology; D005109:Extracellular Matrix / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases / Q000378:metabolism*
D000588:Amines; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins; D002118:Calcium