Large cell neuroendocrine carcinoma of the head and neck.
Large cell neuroendocrine carcinoma is a poorly differentiated neuroendocrine carcinoma that usually occurs in the lung. Although rare in the head and neck, salivary and mucosal subtypes are recognized. This article describes their characteristic light microscopic and immunohistochemical features and highlights the importance of accurate diagnosis, management and prognostic implications.
Pathology Division, Shizuoka Cancer Center Hospital and Research Institute, Shizuoka, Japan.
Kimihide
K
Kusafuka
Alfio
A
Ferlito
James S
JS
Lewis
Julia A
JA
Woolgar
Alessandra
A
Rinaldo
Pieter J
PJ
Slootweg
Douglas R
DR
Gnepp
Kenneth O
KO
Devaney
William D
WD
Travis
Leon
L
Barnes
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018287:Carcinoma, Large Cell / Q000473:pathology* / Q000628:therapy; D018278:Carcinoma, Neuroendocrine / Q000473:pathology* / Q000628:therapy; D003937:Diagnosis, Differential; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology; D011379:Prognosis; D012468:Salivary Gland Neoplasms / Q000473:pathology / Q000628:therapy