Morphologic analysis of fetal stress organsin different causes of perinatal death.
Complications act as stress-inducers during pregnancy so the fetus can develop functional compensatory mechanisms or morphologic changes. The cases analyzed are with congenital malformations or acute stress; chronic included cases with ascending infection (AI) and perinatal hypoxia/anoxia (PHA). The hematoxylin-eosin (H&E) was done to analyze the vacuolization, and the immunohistochemistry to the phagocytosis. The discreet standard of vacuolization was observed in 52.6% of the cases, 22.1% moderate, and 25.3% severe. The number of macrophages was higher in PHA. Changes in these organs are closely related to the cause of death and to the period during which the harmful agent.
General Pathology Department, Triângulo Mineiro Federal University, Uberaba, Minas Gerais State, Brazil. rosana@patge.uftm.edu.br
Rosana Rosa Miranda
RR
Corrêa
Ana Paula
AP
Espíndula
Renata Calciolari Rossi E
RC
Silva
João Carlos
JC
Saldanha
Camila Souza de Oliveira
CS
Guimarães
Camila Lourencini
CL
Cavellani
Marlene Antônia Dos
MA
Reis
Vicente de Paula Antunes
Vde P
Teixeira
Eumenia Costa da Cunha
EC
Castro
D000302:Adrenal Cortex / Q000196:embryology / Q000378:metabolism / Q000473:pathology; D000328:Adult; D001424:Bacterial Infections / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D002452:Cell Count; D000013:Congenital Abnormalities; D005260:Female; D005313:Fetal Death; D005315:Fetal Diseases / Q000401:mortality / Q000473:pathology*; D005311:Fetal Hypoxia / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D005865:Gestational Age; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D007239:Infections; D008264:Macrophages / Q000473:pathology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D047928:Premature Birth; D013312:Stress, Physiological; D013950:Thymus Gland / Q000473:pathology; D014617:Vacuoles / Q000473:pathology