No reduction of HCV viral load in HIV patients co-infected with HCV genotype 1 during a 30 days course of nitazoxanide monotherapy.
There are two new drugs approved and several in development for treatment of chronic HCV; among them nitazoxanide (NTZ). Twelve HIV/HCV genotype 1 co-infected patients were enrolled prospectively to receive a 30 days course of oral NTZ 500 mg bid. This therapy was well tolerated in this group of HIV patients co-infected with HCV genotype 1. Nevertheless no changes in HCV viral load were observed during treatment in none of the patients evaluated. This data suggests that despite the promising results reported for HCV genotype 4 mono-infected patients, NTZ exhibit poor activity as monotherapy in HIV/HCV co-infected patients with genotype 1.
Centro Nacional de Referencia para el SIDA, Universidad de Buenos Aires, Argentina. natalialaufer@gmail.com
N
N
Laufer
L
L
Abusamra
F
F
Bolcic
A
A
Gun
M J
MJ
Rolón
H
H
Pérez
A
A
Krolewiecki
H
H
Salomón
J
J
Quarleri
P
P
Cahn
D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D060085:Coinfection / Q000188:drug therapy*; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000150:complications*; D016174:Hepacivirus / Q000235:genetics; D019698:Hepatitis C, Chronic / Q000150:complications / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009574:Nitro Compounds; D010865:Pilot Projects; D013844:Thiazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D017211:Treatment Failure; D019562:Viral Load / Q000187:drug effects*
D000998:Antiviral Agents; D009574:Nitro Compounds; D013844:Thiazoles; C041747:nitazoxanide