"SNP Snappy": a strategy for fast genome-wide association studies fitting a full mixed model.
A strategy to reduce computational demands of genome-wide association studies fitting a mixed model is presented. Improvements are achieved by utilizing a large proportion of calculations that remain constant across the multiple analyses for individual markers involved, with estimates obtained without inverting large matrices.
Animal Genetics and Breeding Unit, University of New England, Armidale NSW 2351, Australia. kmeyer.agbu@gmail.com
Karin
K
Meyer
Bruce
B
Tier
D000465:Algorithms; D000818:Animals; D019295:Computational Biology / Q000379:methods; D003198:Computer Simulation; D055106:Genome-Wide Association Study; D020407:Internet; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D012984:Software