Regulation of platelet biology by platelet endothelial cell adhesion molecule-1.
Platelet endothelial cell adhesion molecule-1 (PECAM-1), an immunoreceptor tyrosine-based inhibitory motif containing receptor, plays diverse and apparently contradictory roles in regulating the response of platelets to stimuli; inhibiting platelet response to immunoreceptor tyrosine-based activation motif and G protein-coupled receptor signalling following stimulation with collagen, adenosine diphosphate, and thrombin, as well as enhancing integrin outside-in signalling. These dual, and opposing, roles suggest an important and complex role for PECAM-1 in orchestrating platelet response to vascular damage. Indeed, during thrombus formation, the influence of PECAM-1 on the multiple signalling pathways combines leading to a relatively large inhibitory effect on thrombus formation.
Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, UK. c.i.jones@reading.ac.uk
Chris I
CI
Jones
Leonardo A
LA
Moraes
Jonathan M
JM
Gibbins
D001792:Blood Platelets / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000097:blood* / Q000737:chemistry; D015398:Signal Transduction
D019408:Platelet Endothelial Cell Adhesion Molecule-1