[Primary aldosteronism in a patient after surgical treatment of primary hyperparathyroidism].
The presence of both parathyroid adenoma and primary aldosteronism in the same person has been reported in only few patients. Taking into account a relatively high prevalence of both primary hyperparathyroidism and primary aldosteronism in the general population, these findings may be explained by a simple coincidence of both these disorders. In the present paper, we report a man with a family history of multiple endocrine neoplasia type 1 (MEN-1), who developed primary aldosteronism eight years after removal of parathyroid adenoma. We report in details diagnostic and treatment strategies applied in our patient and their impact on the course and outcome of both these disorders. In our opinion, the described case of our patient represents an atypical presentation of MEN-1 syndrome, a hereditary syndrome characterized by a variety of endocrine neoplasias and hormone excess syndromes, particularly tumors of the parathyroid glands, pancreatic islet cells, and pituitary gland. We conclude that each person with MEN-1 syndrome and the presence of adrenal lesions should be assessed for the presence of excess mineralocorticoid activity.
Klinika Chorób Wewnetrznych i Farmakologii, Klinicznej Katedry Farmakologii, Slaskiego Uniwersytetu Medycznego w Katowicach. r.krysiak@interia.pl
Robert
R
Krysiak
Iwona
I
Kobielusz-Gembala
Bogusław
B
Okopień
D000236:Adenoma / Q000150:complications / Q000601:surgery*; D003937:Diagnosis, Differential; D006801:Humans; D006929:Hyperaldosteronism / Q000175:diagnosis / Q000209:etiology*; D006961:Hyperparathyroidism / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D018761:Multiple Endocrine Neoplasia Type 1 / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D010282:Parathyroid Neoplasms / Q000150:complications / Q000601:surgery*