Secondary metabolites isolated from Piper chimonantifolium and their antifungal activity.
In this study, the CH(2)Cl(2) extract from leaves of Piper chimonantifolium was subjected to several chromatographic separation procedures to afford one chromene (gaudichaudianic acid) as a major compound as well as two flavonoids (dihydrooroxylin and pinocembrin) and three steroids (sitosterol, sitosteryl palmitate and stigmasterol). The structures of all determined compounds were characterised by spectrometric analysis, mainly mass spectrometry and NMR, as well as their optical properties. This article describes the first phytochemical study of the leaves of P. chimonantifolium and an evaluation of the antifungal activity of its major compounds.
Departamento de Ciências Exatas e da Terra, Universidade Federal de São Paulo, 09972-270, Diadema, SP, Brazil. joao.lago@unifesp.br
João Henrique G
JH
Lago
Alexandre T
AT
Ito
César M
CM
Fernandes
Maria Claudia M
MC
Young
Massuo J
MJ
Kato
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification*; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D010840:Phytosterols / Q000737:chemistry / Q000302:isolation & purification*; D031701:Piper / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry
D000935:Antifungal Agents; D001578:Benzopyrans; D010840:Phytosterols; D010936:Plant Extracts