Embryonic stem cells: testing the germ-cell theory.
The exact cellular origin of embryonic stem cells remains elusive. Now a new study provides compelling evidence that embryonic stem cells, established under conventional culture conditions, originate from a transient germ-cell state.
Howard Hughes Medical Institute and Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA. khochedlinger@helix.mgh.harvard.edu
Konrad
K
Hochedlinger
D000818:Animals; D053595:Embryonic Stem Cells / Q000502:physiology*; D039904:Pluripotent Stem Cells / Q000502:physiology*; D000074462:Positive Regulatory Domain I-Binding Factor 1; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism*
C513258:Prdm1 protein, mouse; D014157:Transcription Factors; D000074462:Positive Regulatory Domain I-Binding Factor 1