title: Refinement of 1p36 alterations not involving PRDM16 in myeloid and lymphoid malignancies.
abstract: Fluorescence in situ hybridization was performed to characterize 81 cases of myeloid and lymphoid malignancies with cytogenetic 1p36 alterations not affecting the PRDM16 locus. In total, three subgroups were identified: balanced translocations (N = 27) and telomeric rearrangements (N = 15), both mainly observed in myeloid disorders; and unbalanced non-telomeric rearrangements (N = 39), mainly observed in lymphoid proliferations and frequently associated with a highly complex karyotype. The 1p36 rearrangement was isolated in 12 cases, mainly myeloid disorders. The breakpoints on 1p36 were more widely distributed than previously reported, but with identifiable rare breakpoint cluster regions, such as the TP73 locus. We also found novel partner loci on 1p36 for the known multi-partner genes HMGA2 and RUNX1. We precised the common terminal 1p36 deletion, which has been suggested to have an adverse prognosis, in B-cell lymphomas [follicular lymphomas and diffuse large B-cell lymphomas with t(14;18)(q32;q21) as well as follicular lymphomas without t(14;18)]. Intrachromosomal telomeric repetitive sequences were detected in at least half the cases of telomeric rearrangements. It is unclear how the latter rearrangements occurred and whether they represent oncogenic events or result from chromosomal instability during oncogenesis.
authors: Center for Human Genetics, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
authors: Francois P
authors: FP
authors: Duhoux
authors: Geneviève
authors: G
authors: Ameye
authors: Virginie
authors: V
authors: Lambot
authors: Christian
authors: C
authors: Herens
authors: Frédéric
authors: F
authors: Lambert
authors: Sophie
authors: S
authors: Raynaud
authors: Iwona
authors: I
authors: Wlodarska
authors: Lucienne
authors: L
authors: Michaux
authors: Catherine
authors: C
authors: Roche-Lestienne
authors: Elise
authors: E
authors: Labis
authors: Sylvie
authors: S
authors: Taviaux
authors: Elise
authors: E
authors: Chapiro
authors: Florence
authors: F
authors: Nguyen-Khac
authors: Florence Nguyen
authors: FN
authors: Khac
authors: Stéphanie
authors: S
authors: Struski
authors: Sophie
authors: S
authors: Dobbelstein
authors: Nicole
authors: N
authors: Dastugue
authors: Eric
authors: E
authors: Lippert
authors: Frank
authors: F
authors: Speleman
authors: Nadine
authors: N
authors: Van Roy
authors: An
authors: A
authors: De Weer
authors: Katrina
authors: K
authors: Rack
authors: Pascaline
authors: P
authors: Talmant
authors: Steven
authors: S
authors: Richebourg
authors: Francine
authors: F
authors: Mugneret
authors: Isabelle
authors: I
authors: Tigaud
authors: Marie-Joëlle
authors: MJ
authors: Mozziconacci
authors: Sophy
authors: S
authors: Laibe
authors: Nathalie
authors: N
authors: Nadal
authors: Christine
authors: C
authors: Terré
authors: Jeanne-Marie
authors: JM
authors: Libouton
authors: Anabelle
authors: A
authors: Decottignies
authors: Miikka
authors: M
authors: Vikkula
authors: Hélène A
authors: HA
authors: Poirel
mesh_terms: D002460:Cell Line; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D004268:DNA-Binding Proteins / Q000235:genetics*; D019337:Hematologic Neoplasms / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D020641:Polymorphism, Single Nucleotide; D016615:Telomere; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; C416371:PRDM16 protein, human; D014157:Transcription Factors