title: Ficus platyphylla promotes fertility in female Rattus norvegicus Wistar strain: a preliminary study.
abstract: BACKGROUND
  Ficus platyphylla Delile (family-Moracea) commonly called gutta percha tree is a deciduous plant found in savannah areas. It grows widely in the Northern part of Nigeria, up to 60 ft. high and is known as 'gamji' by the Hausas. The seeds, bark and leaves have been used traditionally in combination to promote fertility. Scientifically, the plant has been shown to have analgesic, anti-inflammatory and CNS effects. The present study was to validate the use of this plant to promote fertility in female Rattus norvegicus Wistar strain using various fertility parameters.
  
  
  METHODS
  Female Rattus norvegicus Wistar strain weighing between 150-180 g were randomly selected and divided into two major groups. Each group was subdivided into 5 treatment groups of 100, 200, 400 mg/kg BW of aqueous extract of F. platyphylla and a control group of 5 ml/kg of distilled water. A positive control of clomiphene citrate was used. Treatment of the first group was discontinued after 15 days prior to mating (pre-mating treatment group), while the other was treated continuously till delivery (continuous treatment group). At the 10th day, females were sacrificed and implantation sites were checked and embryos counted. Upon delivery, litter sizes were determined and the pups weighed and checked for deformities. Other reproductive indices were calculated. Data were analyzed by one-way analysis of variance and students T-test. Proportions were analysed by Chi square. Statistical evaluations were performed using STATS programs and Graphpad prism, and a difference was considered statistically significant at P < 0.05.
  
  
  RESULTS
  There was a significant reduction in the percentage post implantation losses of both the pre-treatment and the continuous treatment groups when compared to their distil water controls. The litter size of the pre-treatment group was similar to the distil water group while at 400 mg/kg, the continuous treatment group showed an increase in the litter size similar to that of the clomiphene group. There were no observed external deformities in the pups.
  
  
  CONCLUSIONS
  Administration of aqueous extract of F. platyphylla promotes fertility by reducing post implantation loss and by increasing litter size in female Rattus norvegicus Wistar strain.
authors: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University Sokoto, Nigeria. nenye789@yahoo.com
authors: Chinenye J
authors: CJ
authors: Ugwah-Oguejiofor
authors: Shaibu O
authors: SO
authors: Bello
authors: Raymond U
authors: RU
authors: Okolo
authors: Emmanuel U
authors: EU
authors: Etuk
authors: Michael O
authors: MO
authors: Ugwah
authors: Vincent U
authors: VU
authors: Igbokwe
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D004305:Dose-Response Relationship, Drug; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects*; D030681:Ficus / Q000737:chemistry*; D008098:Litter Size / Q000187:drug effects; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D010936:Plant Extracts