title: Exercise effects on depressive symptoms in cancer survivors: a systematic review and meta-analysis.
abstract: BACKGROUND
  Depression is a distressing side effect of cancer and its treatment. In the general population, exercise is an effective antidepressant.
  
  
  OBJECTIVE
  We conducted a systematic review and meta-analysis to determine the antidepressant effect of exercise in cancer survivors.
  
  
  METHODS
  In May 2011, we searched MEDLINE, PsycInfo, EMBASE, CINAHL, CDSR, CENTRAL, AMED, Biosis Previews, and Sport Discus and citations from relevant articles and reviews.
  
  
  METHODS
  We included randomized controlled trials (RCT) comparing exercise interventions with usual care in cancer survivors, using a self-report inventory or clinician rating to assess depressive symptoms, and reporting symptoms pre- and postintervention.
  
  
  METHODS
  Around 7,042 study titles were identified and screened, with 15 RCTs included.
  
  
  METHODS
  Effect sizes (ES) were reported as mean change scores. The Q test was conducted to evaluate heterogeneity of ES. Potential moderator variables were evaluated with examination of scatter plots and Wilcoxon rank-sum or Kruskal-Wallis tests.
  
  
  RESULTS
  The overall ES, under a random-effects model, was -0.22 (confidence interval, -0.43 to -0.09; P = 0.04). Significant moderating variables (ps < 0.05) were exercise location, exercise supervision, and exercise duration.
  
  
  CONCLUSIONS
  Only one study identified depression as the primary endpoint.
  
  
  CONCLUSIONS
  Exercise has modest positive effects on depressive symptoms with larger effects for programs that were supervised or partially supervised, not conducted at home, and at least 30 minutes in duration.
  
  
  CONCLUSIONS
  Our results complement other studies showing that exercise is associated with reduced pain and fatigue and with improvements in quality of life among cancer survivors.
authors: Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N. Lake Shore Drive, Suite 1400, Chicago, IL 60611, USA. lynette-craft@northwestern.edu
authors: Lynette L
authors: LL
authors: Craft
authors: Erik H
authors: EH
authors: Vaniterson
authors: Irene B
authors: IB
authors: Helenowski
authors: Alfred W
authors: AW
authors: Rademaker
authors: Kerry S
authors: KS
authors: Courneya
mesh_terms: D003863:Depression / Q000523:psychology / Q000628:therapy*; D015444:Exercise / Q000523:psychology*; D006801:Humans; D009369:Neoplasms / Q000523:psychology*; D010809:Physical Fitness; D011788:Quality of Life; D017741:Survivors