title: Assessment of total uncertainty in cocaine and benzoylecgonine wastewater load measurements.
abstract: To check the effectiveness of campaigns preventing drug abuse or indicating local effects of efforts against drug trafficking, it is beneficial to know consumed amounts of substances in a high spatial and temporal resolution. The analysis of drugs of abuse in wastewater (WW) has the potential to provide this information. In this study, the reliability of WW drug consumption estimates is assessed and a novel method presented to calculate the total uncertainty in observed WW cocaine (COC) and benzoylecgonine (BE) loads. Specifically, uncertainties resulting from discharge measurements, chemical analysis and the applied sampling scheme were addressed and three approaches presented. These consist of (i) a generic model-based procedure to investigate the influence of the sampling scheme on the uncertainty of observed or expected drug loads, (ii) a comparative analysis of two analytical methods (high performance liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry), including an extended cross-validation by influent profiling over several days, and (iii) monitoring COC and BE concentrations in WW of the largest Swiss sewage treatment plants. In addition, the COC and BE loads observed in the sewage treatment plant of the city of Berne were used to back-calculate the COC consumption. The estimated mean daily consumed amount was 107 ± 21 g of pure COC, corresponding to 321 g of street-grade COC.
authors: Dept. of Clinical Research, University of Berne, Berne, Switzerland.
authors: Christoph
authors: C
authors: Mathieu
authors: Jörg
authors: J
authors: Rieckermann
authors: Jean-Daniel
authors: JD
authors: Berset
authors: Stefan
authors: S
authors: Schürch
authors: Rudolf
authors: R
authors: Brenneisen
mesh_terms: D003042:Cocaine / Q000031:analogs & derivatives* / Q000032:analysis*; D003198:Computer Simulation; D008956:Models, Chemical; D009010:Monte Carlo Method; D012722:Sewage / Q000737:chemistry; D013269:Stochastic Processes; D013557:Switzerland; D035501:Uncertainty; D014865:Waste Disposal, Fluid; D014874:Water Pollutants, Chemical / Q000032:analysis*; D018508:Water Purification
chemical_list: D012722:Sewage; D014874:Water Pollutants, Chemical; C005618:benzoylecgonine; D003042:Cocaine