title: Interactions of metal ions with DNA, its constituents and derivatives, which may be relevant for anticancer research.
abstract: In this review several types of interactions between metal ions and DNA are given, starting from basic binding to the use of metal complexes in cancer treatment and diagnostics. Metal cations help to neutralize the negative charge of DNA and thus enable the normal functions of DNA but many other interactions are also possible and are discussed in this paper. Various consequences of such interactions can be reversible (e. g. conformational changes) or irreversible (e. g. cleavage). It is known that some metal ions can also damage DNA which can provoke mutations and in some cases leads to cancer. It is clear that we know a lot about metal-DNA interactions but much more information is needed to understand the role of metal ions completely and to use this knowledge successfully.
authors: Faculty of Chemistry and Chemical Technology, University of Ljubljana, Askerceva 5, 1000 Ljubljana, Slovenia. iztok.turel@fkkt.uni-lj.si
authors: Iztok
authors: I
authors: Turel
authors: Jakob
authors: J
authors: Kljun
mesh_terms: D000963:Antimetabolites / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D001665:Binding Sites; D002412:Cations / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D056831:Coordination Complexes / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D053837:DNA Cleavage / Q000187:drug effects; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry; D008670:Metals / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy*; D009690:Nucleic Acid Conformation / Q000187:drug effects; D009711:Nucleotides / Q000737:chemistry / Q000378:metabolism; D009942:Organometallic Compounds / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D000963:Antimetabolites; D000970:Antineoplastic Agents; D002412:Cations; D056831:Coordination Complexes; D008670:Metals; D009711:Nucleotides; D009942:Organometallic Compounds; D004247:DNA