title: Peroxisome proliferator-activated receptor α (PPARα) activation advances locomotor activity and feeding daily rhythms in mice.
abstract: Peroxisome proliferator-activated receptors (PPARs) are key mediators of energy homeostasis, and lipid and glucose metabolism that exhibit circadian expression. PPAR activating drugs are used clinically as lipid and glucose-lowering drugs. We evaluated the effect of long-term (11 weeks) PPARα and PPARγ activation using bezafibrate and rosiglitazone, respectively, on metabolism, locomotor activity and feeding rhythms of non-obese mice. We found that bezafibrate, but not rosiglitazone, led to no weight gain and a slight weight loss with reduced epididymal fat pads. Although rosiglitazone had a minor effect on 24-h food intake rhythm, bezafibrate treatment was accompanied by increased amplitude and an advanced acrophase of the 24-h feeding rhythm. Similarly, unlike rosiglitazone, bezafibrate treatment was accompanied by a significantly advanced acrophase of locomotor activity rhythm under constant darkness conditions. As disrupted circadian rhythms lead to obesity, PPARα activation can serve as a clinical target for the modulation of both circadian rhythms and metabolism.
authors: Institute of Biochemistry, Food Science and Nutrition, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.
authors: R
authors: R
authors: Gutman
authors: M
authors: M
authors: Barnea
authors: L
authors: L
authors: Haviv
authors: N
authors: N
authors: Chapnik
authors: O
authors: O
authors: Froy
mesh_terms: D000818:Animals; D001629:Bezafibrate / Q000494:pharmacology*; D015153:Blotting, Western; D002940:Circadian Rhythm; D005247:Feeding Behavior / Q000187:drug effects; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D047493:PPAR alpha / Q000187:drug effects / Q000378:metabolism*; D012333:RNA, Messenger; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000494:pharmacology*; D013997:Time Factors; D014157:Transcription Factors / Q000235:genetics
chemical_list: D000960:Hypolipidemic Agents; D047493:PPAR alpha; D012333:RNA, Messenger; D045162:Thiazolidinediones; D014157:Transcription Factors; D000077154:Rosiglitazone; D001629:Bezafibrate