title: Lack of correlation between catalytic efficiency and basicity of amines during the reaction of aryl methyl ketones with DMF-DMA: an unprecedented supramolecular domino catalysis.
abstract: 1-Methylimidazole exhibits an unusually high efficiency in promoting the reaction of aryl methyl ketones with DMF-DMA to form (2E)-1-aryl-3-dimethylamino-2-propenones which lacks correlation between the catalytic efficiency and the basicity of 1-methylimidazole in comparison to other amines. An unprecedented supramolecular domino catalysis rationalises the lack of correlation between the catalytic efficiency and basicity of the amines. The supramolecular assemblies have been characterized by mass-spectrometric ion fishing. The time-dependent increase/decrease in the concentration (ion current) of the supramolecular species consolidated the mechanism.
authors: Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S. A. S. Nagar, 160 062, Punjab, India.
authors: Anirban
authors: A
authors: Sarkar
authors: Sudipta
authors: S
authors: Raha Roy
authors: Dinesh
authors: D
authors: Kumar
authors: Chetna
authors: C
authors: Madaan
authors: Santosh
authors: S
authors: Rudrawar
authors: Asit K
authors: AK
authors: Chakraborti
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D004126:Dimethylformamide / Q000031:analogs & derivatives* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D046911:Macromolecular Substances / Q000737:chemistry; D015394:Molecular Structure; D011407:Propane / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000588:Amines; D007659:Ketones; D046911:Macromolecular Substances; C022083:dimethylformamide-dimethylacetal; D004126:Dimethylformamide; D011407:Propane