title: Soyabean glyceollins: biological effects and relevance to human health.
abstract: Glyceollins, one family of phytoalexins, are de novo synthesised from daidzein in the soyabean upon exposure to some types of fungus. The efficiency of glyceollin production appears to be influenced by soyabean variety, fungal species, and the degree of physical damage to the soyabean. The compounds have been shown to have strong antioxidant and anti-inflammatory activities, and to inhibit the proliferation and migration of human aortic smooth muscle cells, suggesting their potential to prevent atherosclerosis. It has also been reported that glyceollins have inhibited the growth of prostate and breast cancer cells in xenograft animal models, which is probably due to their anti-oestrogenic activity. In essence, glyceollins deserve further animal and clinical studies to confirm their health benefits.
authors: School of Applied Bioscience, School of Food Science and Biotechnology, BK21 Research Team for Developing Functional Health Food Materials, Kyungpook National University, Deagu 702-701, Republic of Korea.
authors: Hyo Jung
authors: HJ
authors: Kim
authors: Ji-Sun
authors: JS
authors: Lim
authors: Woo-Keun
authors: WK
authors: Kim
authors: Jong-Sang
authors: JS
authors: Kim
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology / Q000627:therapeutic use*; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D050197:Atherosclerosis / Q000517:prevention & control*; D001943:Breast Neoplasms / Q000517:prevention & control; D004965:Estrogen Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D011471:Prostatic Neoplasms / Q000517:prevention & control; D036343:Pterocarpans / Q000096:biosynthesis / Q000494:pharmacology / Q000627:therapeutic use*; D012717:Sesquiterpenes / Q000494:pharmacology / Q000627:therapeutic use; D013025:Glycine max / Q000737:chemistry*; D000094162:Phytoalexins
chemical_list: D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D004965:Estrogen Antagonists; D010936:Plant Extracts; D036343:Pterocarpans; D012717:Sesquiterpenes; C017343:glyceollin; D000094162:Phytoalexins