title: [Simulation study of antithrombotic active fraction of Naodesheng by support vector machine].
abstract: OBJECTIVE
  To screen the antithrombotic active fraction of Naodesheng.
  
  
  METHODS
  The collagen and adrenaline-induced thrombosis by tail intravenous injection in mice was used. Based on orthogonal design, the support vector machine model was established for pharmacodynamics prediction of TCM prescriptions.
  
  
  RESULTS
  The model established in this study could predict the drug actions of different combinations.
  
  
  CONCLUSIONS
  The pharmacodynamic actions of several formulas are superior to that of the original formula and CD has the best effect.
authors: School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China. lishuxian631@163.com
authors: Shu-xian
authors: SX
authors: Li
authors: Chao
authors: C
authors: Chen
authors: Shu-mei
authors: SM
authors: Wang
authors: Xiao-hui
authors: XH
authors: Deng
authors: Sheng-wang
authors: SW
authors: Liang
mesh_terms: D000465:Algorithms; D000818:Animals; D005591:Chemical Fractionation; D003198:Computer Simulation; D004338:Drug Combinations; D055808:Drug Discovery / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D005343:Fibrinolytic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D015233:Models, Statistical; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D013329:Structure-Activity Relationship; D060388:Support Vector Machine; D013927:Thrombosis / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005343:Fibrinolytic Agents; C546210:naodesheng