title: The identification of two subgroups of obese women with differing endometrial proliferation levels: potential consequences in the development of endometrial cancer.
abstract: Enhanced endometrial proliferation correlates obesity to type-I (estrogen-dependent) endometrial cancer (EC). Our aim was to distinguish obese women (without EC) with differing endometrial proliferation. Endometrial and blood samples were obtained from normal-weight and obese women without EC. Type-I EC samples were obtained from obese patients. On measuring endometrial proliferation (Ki67 and phosphorylated histone H3 (p-H3)), two groups of obese women without EC were identified: obese(High Proliferating) (O(HP)) and obese(Low Proliferating) (O(LP)). Increased Ki67 (88.5%, P<0.001), p-H3 (62.6%, P<0.01), 17β-estradiol/progesterone ratio (46.3%, P<0.01) and endometrial estrogen receptor alpha (ERα) (82.2%, P<0.001) were observed in O(HP) compared with O(LP) patients. ECs possessed similar ERα and enhanced proliferation as O(HP), suggesting that O(HP) women are at higher risk of type-I EC. O(LP) women were indistinguishable from normal-weight women regarding these determinants of endometrial proliferation, ERα and 17β-estradiol/progesterone ratio. Our data may further define the obesity phenotype in regards to type-I EC risk and may help identify obese women more susceptible to develop type-I EC, allowing early intervention and a potential reduction in mortality.
authors: Institute of Nutrition & Food Technology, University of Chile, Santiago, Chile. avillavicencio@inta.uchile.cl
authors: A
authors: A
authors: Villavicencio
authors: G
authors: G
authors: Aguilar
authors: J
authors: J
authors: Acuña
authors: F
authors: F
authors: Gabler
authors: E
authors: E
authors: Soto
authors: F
authors: F
authors: Gaete
authors: P
authors: P
authors: Peñaloza
authors: M
authors: M
authors: Celis
authors: G I
authors: GI
authors: Owen
mesh_terms: D000328:Adult; D000368:Aged; D049109:Cell Proliferation; D016889:Endometrial Neoplasms / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D004717:Endometrium / Q000473:pathology*; D004958:Estradiol / Q000378:metabolism*; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D010641:Phenotype; D011374:Progesterone / Q000378:metabolism*
chemical_list: C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D019394:Ki-67 Antigen; D011374:Progesterone; D004958:Estradiol