title: Enzyme responsive luminescent ruthenium(II) cephalosporin probe for intracellular imaging and photoinactivation of antibiotics resistant bacteria.
abstract: The Főrster resonance energy transfer (FRET) based luminescent ruthenium(II) cephalosporin probe has been designed and synthesized, which can be selectively activated by endogenous β-lactamases and thus provided a localized and specific intracellular luminescence imaging and photoinactivation of drug resistant bacterial pathogens.
authors: Division of Chemistry & Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore.
authors: Qing
authors: Q
authors: Shao
authors: Bengang
authors: B
authors: Xing
mesh_terms: D001419:Bacteria / Q000166:cytology / Q000201:enzymology*; D002511:Cephalosporins / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D024881:Drug Resistance, Bacterial; D031541:Fluorescence Resonance Energy Transfer / Q000379:methods; D049449:Luminescence; D049408:Luminescent Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D012428:Ruthenium / Q000737:chemistry* / Q000378:metabolism; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D002511:Cephalosporins; D049408:Luminescent Agents; D012428:Ruthenium; D001618:beta-Lactamases