title: Transgenic rice accumulating modified cedar pollen allergen Cry j 2 derivatives.
abstract: In order to create a safe tolerogenic antigen with reduced IgE reactivity, we developed transgenic rice that accumulates in the seed endosperm a sufficient amount of Cry j 2, the cedar pollen allergen, in a restructured form of tail-to-head, providing a feasible mucosal allergy vaccine against cedar pollinosis.
authors: Functional Crop Research and Development Unit, National Institute of Agrobiological Science, 2-1-2 Kannondai, Tsukuba, Ibaraki 305-8602, Japan.
authors: Kazuya
authors: K
authors: Suzuki
authors: Lijun
authors: L
authors: Yang
authors: Fumio
authors: F
authors: Takaiwa
mesh_terms: D000485:Allergens / Q000096:biosynthesis / Q000235:genetics* / Q000276:immunology; D052179:Antigens, Plant / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology; D032485:Cryptomeria / Q000276:immunology; D007073:Immunoglobulin E / Q000276:immunology; D012275:Oryza / Q000235:genetics* / Q000378:metabolism; D010940:Plant Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000276:immunology; D030821:Plants, Genetically Modified / Q000378:metabolism; D011058:Pollen / Q000276:immunology; D012639:Seeds / Q000378:metabolism
chemical_list: D000485:Allergens; D052179:Antigens, Plant; C065291:Cry j II protein, Cryptomeria japonica; D010940:Plant Proteins; D007073:Immunoglobulin E