title: Regulation of TRPM8 channel activity.
abstract: Transient Receptor Potential Melastatin 8 (TRPM8) is a Ca(2+) permeable non-selective cation channel directly activated by cold temperatures and chemical agonists such as menthol. It is a well established sensor of environmental cold temperatures, found in peripheral sensory neurons, where its activation evokes depolarization and action potentials. The activity of TRPM8 is regulated by a number of cellular signaling pathways, most notably by phosphoinositides and the activation of phospholipase C. This review will summarize current knowledge on the physiological and pathophysiological roles of TRPM8 and its regulation by various intracellular messenger molecules and signaling pathways.
authors: Department of Pharmacology and Physiology, UMDNJ - New Jersey Medical School, Newark, NJ 07103, USA.
authors: Yevgen
authors: Y
authors: Yudin
authors: Tibor
authors: T
authors: Rohacs
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000982:Antipruritics / Q000494:pharmacology; D003080:Cold Temperature; D004789:Enzyme Activation / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D008610:Menthol / Q000494:pharmacology; D010716:Phosphatidylinositols / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D050053:TRPM Cation Channels / Q000378:metabolism*; D013823:Thermoreceptors / Q000166:cytology / Q000378:metabolism*; D010738:Type C Phospholipases / Q000378:metabolism
chemical_list: D000982:Antipruritics; D010716:Phosphatidylinositols; D050053:TRPM Cation Channels; C425966:TRPM8 protein, human; D008610:Menthol; D010738:Type C Phospholipases