title: Mechanisms of Cisplatin nephrotoxicity.
abstract: Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has uncovered many of the cellular mechanisms which underlie cisplatin-induced renal cell death. It has also become apparent that inflammation provoked by injury to renal epithelial cells serves to amplify kidney injury and dysfunction in vivo. This review summarizes recent advances in our understanding of cisplatin nephrotoxicity and discusses how these advances might lead to more effective prevention.
authors: Division of Nephrology, The Pennsylvania State University College of Medicine, Hershey, PA, USA. RMiller8@hmc.psu.edu
authors: Ronald P
authors: RP
authors: Miller
authors: Raghu K
authors: RK
authors: Tadagavadi
authors: Ganesan
authors: G
authors: Ramesh
authors: William Brian
authors: WB
authors: Reeves
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000633:toxicity*; D017209:Apoptosis / Q000187:drug effects; D002945:Cisplatin / Q000493:pharmacokinetics / Q000633:toxicity*; D004249:DNA Damage; D004195:Disease Models, Animal; D004847:Epithelial Cells / Q000187:drug effects / Q000473:pathology; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D009393:Nephritis / Q000139:chemically induced* / Q000473:pathology; D012307:Risk Factors
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin