title: Recent advance in aminopeptidase N (APN/CD13) inhibitor research.
abstract: APN is an important zinc dependent metallo-exopeptidase, which can degrade the extracellular matrix, and plays an important role in tumor invasion, metastasis and angiogenesis. it has been considered as a suitable target for anti-cancer drug design. Recently, research of structure-based APN inhibitors is becoming an interesting field, and many APN inhibitors have been reported. Here we review a series of APN inhibitors and the recent progress in this field.
authors: Department of Medicinal Chemistry, School of Pharmaceutical Sciences, ShanDong University, 250012, Ji'nan, ShanDong, PR China.
authors: X
authors: X
authors: Zhang
authors: H
authors: H
authors: Fang
authors: J
authors: J
authors: Zhang
authors: Y
authors: Y
authors: Yuan
authors: W
authors: W
authors: Xu
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D018826:CD13 Antigens / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015195:Drug Design; D006801:Humans; D008958:Models, Molecular; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D018826:CD13 Antigens