title: Anticancer platinum (IV) prodrugs with novel modes of activity.
abstract: Over the past four decades, the search for improved platinum drugs based on the classical platinum (II)-diam(m)ine pharmacophore has yielded only a handful of successful candidates. New methodologies centred on platinum (IV) complexes, with better stability and expanded coordination spheres, offer the possibility of overcoming limitations inherent to platinum (II) drugs. In this review, novel strategies of targeting and killing cancer cells using platinum (IV) constructs are discussed. These approaches exploit the unique electrochemical characteristics and structural attributes of platinum (IV) complexes as a means of developing anticancer prodrugs that can target and selectively destroy cancer cells. Anticancer platinum (IV) prodrugs represent promising new strategies as targeted chemotherapeutic agents in the ongoing battle against cancer.
authors: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
authors: Chee Fei
authors: CF
authors: Chin
authors: Daniel Yuan Qiang
authors: DY
authors: Wong
authors: Ramasamy
authors: R
authors: Jothibasu
authors: Wee Han
authors: WH
authors: Ang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000627:therapeutic use; D016503:Drug Delivery Systems; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D037742:Nanotubes, Carbon / Q000737:chemistry; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D009944:Organoplatinum Compounds / Q000737:chemistry* / Q000627:therapeutic use; D010789:Phototherapy; D010984:Platinum / Q000737:chemistry*; D011355:Prodrugs / Q000737:chemistry* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D037742:Nanotubes, Carbon; D009944:Organoplatinum Compounds; D011355:Prodrugs; D010984:Platinum