title: Synthesis and enantioseparation characteristics of a novel mono-6-deoxy-(2,4-dihydroxybenzimide)-β-cyclodextrin as a chiral stationary phase in high-performance liquid chromatography.
abstract: A novel chiral selector mono-6-deoxy-(2,4-dihydroxybenzimide)-β-CD (MDHB-β-CD) in which the derivatized group and the cavity of CD is linked by CH(2)-N=C group, was successfully prepared, and the structural characteristics were determined by FT-IR, (1)H and (13)C NMR, MALDITOF-MS and element analysis. The corresponding stationary phase (CSP) was used in HPLC and the enantioseparation performance was investigated using chiral 1-phenyl-2-nitroethanol derivatives as test samples in the reverse-phase mode composed of methanol/water and acetonitrile/TEAA. Better separation abilities and excellent enantioselectivities (α>1.26, R(S)>1.73) were obtained on MDHB-β-CD CSP for these chiral compounds in the methanol/water mobile phase.
authors: R&D Center for Pharmaceuticals, School of Chemical Engineering and the Environment, Beijing Institute of Technology, Beijing 100081, China.
authors: Xia
authors: X
authors: Li
authors: Zhiming
authors: Z
authors: Zhou
authors: Li
authors: L
authors: Dai
authors: Wenhong
authors: W
authors: Zhou
authors: Jinliang
authors: J
authors: Wang
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D013237:Stereoisomerism; D047392:beta-Cyclodextrins / Q000032:analysis* / Q000138:chemical synthesis*
chemical_list: D047392:beta-Cyclodextrins