title: Isolated eyelid edema in Melkersson-Rosenthal syndrome: a case series.
abstract: OBJECTIVE
  To report the clinicopathologic features of a series of patients with Melkersson-Rosenthal syndrome (MRS).
  
  
  METHODS
  Patients in this clinicopathological case series were identified through retrospective review. Five Caucasian patients (2 women and 3 men; age range, 46 to 73 years) with isolated eyelid swelling presented over an 11-month period to two Canadian tertiary Oculoplastic referral centres. All underwent clinical examination and had tissue biopsies.
  
  
  RESULTS
  The patients presented with non-pitting, non-pruritic, painless and recurrent eyelid swelling. None had evidence of cranial nerve palsy or fissured tongue. The duration of symptoms before referral was between 1-5 years. Histopathological examination showed granulomatous inflammation in four patients. Granulomatous folliculitis was a novel finding in three patients.
  
  
  CONCLUSIONS
  Monosymptomatic patients with MRS require a high index of suspicion. Histopathological confirmation is vital for the diagnosis.
authors: Department of Ophthalmology and Visual Sciences, QEII Health Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
authors: N G
authors: NG
authors: Rawlings
authors: A A
authors: AA
authors: Valenzuela
authors: L H
authors: LH
authors: Allen
authors: J G
authors: JG
authors: Heathcote
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D001706:Biopsy; D003937:Diagnosis, Differential; D004487:Edema / Q000188:drug therapy; D005141:Eyelid Diseases / Q000188:drug therapy / Q000473:pathology*; D005143:Eyelids / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008556:Melkersson-Rosenthal Syndrome / Q000188:drug therapy / Q000473:pathology*; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D000305:Adrenal Cortex Hormones