title: Relation of leptin, adiponectin and insulin resistance to bone mineral density in type 2 diabetic postmenopausal women.
abstract: BACKGROUND
  Our aim is to identify the relation of leptin, adiponectin and insulin resistance to bone mineral density (BMD) in type 2 diabetic postmenopausal women and compare it with that experienced by nondiabetics.
  
  
  METHODS
  Seventy six postmenopausal female patients were included in the study. Postmenopausal type 2 diabetic (n = 19) and nondiabetic patients (n = 19) with spine and/or hip BMD T score lower than -2 were included in the study, and postmenopausal type 2 diabetic (n = 20) and nondiabetic women (n = 18) with normal BMD (T score > -1) were selected as control groups. Those receiving therapy for osteoporosis, over the age of 65, those who had a disease and were taking a medication that could affect bone metabolism were excluded. Biochemical tests, as well as leptin, adiponectin and insulin levels, were measured and insulin resistance was calculated using the HOMA test.
  
  
  RESULTS
  There was no correlation between low BMD and leptin, adiponectin and insulin resistance. There was only a negative correlation between leptin and femur Ward's triangle BMD.
  
  
  CONCLUSIONS
  Further large-scale studies must to be performed in order to analyse the effects of leptin, adiponectin and insulin resistance on bone metabolism in type 2 diabetic patients.
authors: Department of Internal Medicine, Division of Endocrinology and Metabolism, Faculty of Medicine, Suleyman Demirel University, Turkey.
authors: Banu Kale
authors: BK
authors: Koroglu
authors: Fatma
authors: F
authors: Kiris
authors: Ismail Hakki
authors: IH
authors: Ersoy
authors: Recep
authors: R
authors: Sutcu
authors: Mustafa
authors: M
authors: Yildiz
authors: Oguzhan
authors: O
authors: Aksu
authors: Fatih
authors: F
authors: Ermis
authors: Sidika
authors: S
authors: Ersoy
authors: Mehmet Numan
authors: MN
authors: Tamer
mesh_terms: D052242:Adiponectin / Q000097:blood*; D015992:Body Mass Index; D015519:Bone Density / Q000502:physiology*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance / Q000502:physiology*; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood*; D013223:Statistics as Topic
chemical_list: D052242:Adiponectin; D007328:Insulin; D020738:Leptin