title: Aqueous fenugreek seed extract ameliorates adriamycin-induced cytotoxicity and testicular alterations in albino rats.
abstract: The present work studied the effect of fenugreek seed extracts on cytotoxicity and testicular damage induced by adriamycin (ADR) in albino rats. Administrating animals with ADR caused significant increase in the percentage of chromosomal aberrations, decreased the mitotic index, and induced DNA damage in bone marrow. Testes of ADR-treated rats showed many histopathological alterations and the number of sperm head abnormalities increased. Moreover, the concentration of malondialdehyde (MDA) increased and the activity of catalase (CAT) and superoxide dismutase (SOD) decreased in the testis. Treating animals with ADR and aqueous seed extracts of fenugreek led to an improvement in the cytogenetic effect and testicular alterations induced by ADR. Lipid peroxidation was reduced and the activities of CAT and SOD were increased. In conclusion, the results indicated that fenugreek seeds ameliorated the cytotoxicity and testicular alterations induced by ADR in albino rats and this may be mediated by its potent antioxidant effects.
authors: Department of Zoology, Faculty of Science, Menoufia University, Shibin el-Kom, Egypt. sabsak@yahoo.com
authors: Saber A
authors: SA
authors: Sakr
authors: Salama M
authors: SM
authors: El-Shenawy
authors: Ahmed M
authors: AM
authors: Al-Shabka
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects / Q000473:pathology; D002869:Chromosome Aberrations / Q000187:drug effects; D003603:Cytotoxins / Q000633:toxicity*; D004317:Doxorubicin / Q000633:toxicity*; D008297:Male; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D012639:Seeds; D013077:Sperm Head / Q000187:drug effects / Q000473:pathology; D013737:Testis / Q000187:drug effects* / Q000473:pathology; D029910:Trigonella; D014867:Water
chemical_list: D003603:Cytotoxins; D010936:Plant Extracts; D014867:Water; D004317:Doxorubicin