title: Dimeric ent-kaurane diterpenoids from Isodon excisus.
abstract: Five new dimeric ent-kauranoids, biexcisusins A-E (1-5), were isolated from the aerial parts of Isodon excisus. The structures and relative configurations of these compounds were determined on the basis of spectroscopic data interpretation. Of these, biexcisusins C-E (3-5) are dimeric ent-kaurane diterpenoids exhibiting an unprecedented linkage through a nine-membered lactone ring between two ent-kaurane subunits. Compounds 1-5 showed no inhibitory effects on the LPS-induced production of nitric oxide in murine macrophage RAW264.7 cells, up to a dose of 50 μM.
authors: College of Pharmacy, Chungbuk National University, Cheongju 361-763, Korea.
authors: Seong Su
authors: SS
authors: Hong
authors: Seon A
authors: SA
authors: Lee
authors: Chul
authors: C
authors: Lee
authors: Xiang Hua
authors: XH
authors: Han
authors: Sanggil
authors: S
authors: Choe
authors: Nahyun
authors: N
authors: Kim
authors: Dongho
authors: D
authors: Lee
authors: Chong-Kil
authors: CK
authors: Lee
authors: Youngsoo
authors: Y
authors: Kim
authors: Jin Tae
authors: JT
authors: Hong
authors: Mi Kyeong
authors: MK
authors: Lee
authors: Bang Yeon
authors: BY
authors: Hwang
mesh_terms: D000818:Animals; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D037602:Isodon / Q000737:chemistry*; D007723:Korea; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000494:pharmacology
chemical_list: D045786:Diterpenes, Kaurane; D008070:Lipopolysaccharides; D009569:Nitric Oxide