title: Recent advances and future challenges in glycan microarray technology.
abstract: Glycan microarrays, carrying hundreds of different sugars on chip surfaces, have become a standard tool for the study of interactions of biomolecules with carbohydrates. The chip-based format offers important advantages, including the ability to screen in parallel several thousand binding events on a single slide, the minimal amount of sample required for one experiment, and the multivalent display of sugars on the chip that mimics the presentation of carbohydrates in nature. This chapter presents recent advances and future challenges in glycan microarray technology. We describe different immobilization and detection methods as well as applications in glycomics, drug discovery, and biomedicine.
authors: Instituto de Investigaciones Químicas, Centro de Investigaciones Científicas Isla de la Cartuja, CSIC and US, Sevilla, Spain. jlpaz@iiq.csic.es
authors: José L
authors: JL
authors: de Paz
authors: Peter H
authors: PH
authors: Seeberger
mesh_terms: D046228:Microarray Analysis / Q000379:methods*; D011134:Polysaccharides / Q000138:chemical synthesis / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D011134:Polysaccharides