title: Numerical analysis of micro- and nano-particle deposition in a realistic human upper airway.
abstract: A computational model was developed for studying the flow field and particle deposition in a human upper airway system, including: nasal cavity, nasopharynx, oropharynx, larynx and trachea. A series of coronal CT scan images of a 24 year old woman was used to construct the 3D model. The Lagrangian and Eulerian approaches were used, respectively, to find the trajectories of micro-particles and concentration of nano-particles. The total and regional deposition fractions of micro/nanoparticles were evaluated and the major hot spots for the deposition of inhaled particles were found.
authors: School of Mechanical Engineering, Shiraz University, Shiraz, Iran.
authors: Pejman
authors: P
authors: Farhadi Ghalati
authors: Erfan
authors: E
authors: Keshavarzian
authors: Omid
authors: O
authors: Abouali
authors: Abolhassan
authors: A
authors: Faramarzi
authors: Jiyuan
authors: J
authors: Tu
authors: Alireza
authors: A
authors: Shakibafard
mesh_terms: D000336:Aerosols; D019295:Computational Biology / Q000379:methods*; D003198:Computer Simulation; D005260:Female; D006801:Humans; D057446:Hydrodynamics; D001239:Inhalation / Q000502:physiology; D008954:Models, Biological; D015233:Models, Statistical; D053758:Nanoparticles; D010316:Particle Size; D012137:Respiratory System / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000378:metabolism*; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D000336:Aerosols