title: Oxidative damage in erythrocytes of adult rats and their suckling pups exposed to gibberellic acid.
abstract: Gibberellic acid (GA(3)) is a plant growth regulator used in agriculture worldwide. The present study investigated the propensity of GA(3) to induce hematological disorders. Pregnant Wistar rats were randomly divided into two groups: group I served as controls; group II received orally GA(3) (200 ppm) from the 14th day of pregnancy until day 14 after delivery. GA(3) reduced the number of red blood cells, hemoglobin concentration, and hematocrit in suckling rats, while these parameters remained unchanged in their mothers. White blood cells increased in mothers and were unchanged in their pups. Several studies have associated these hematological disorders with oxidative stress. In fact, GA(3) treatment revealed in erythrocytes a significant increase in malondialdehyde levels and a decrease in antioxidant enzyme activities such as superoxide dismutase, catalase, and glutathione peroxidase. Moreover, a significant decline was observed in acetylcholinesterase activity, glutathione, nonprotein thiols, and vitamin C levels.
authors: Animal Physiology Laboratory, University of Sfax, Sfax, Tunisia.
authors: Afef
authors: A
authors: Troudi
authors: Nejla
authors: N
authors: Soudani
authors: Ibtissem Ben
authors: IB
authors: Amara
authors: Hanen
authors: H
authors: Bouaziz
authors: Fatma Makni
authors: FM
authors: Ayadi
authors: Najiba
authors: N
authors: Zeghal
mesh_terms: D062107:Advanced Oxidation Protein Products / Q000097:blood; D000818:Animals; D000833:Animals, Suckling; D000975:Antioxidants / Q000032:analysis; D001205:Ascorbic Acid / Q000097:blood; D002374:Catalase / Q000097:blood; D060766:Drinking Water; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D005260:Female; D005875:Gibberellins / Q000633:toxicity*; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress / Q000187:drug effects*; D010937:Plant Growth Regulators / Q000633:toxicity*; D011247:Pregnancy; D050050:Protein Carbonylation / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D062107:Advanced Oxidation Protein Products; D000975:Antioxidants; D060766:Drinking Water; D005875:Gibberellins; D010937:Plant Growth Regulators; D008315:Malondialdehyde; C007842:gibberellic acid; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; D001205:Ascorbic Acid