title: [Surgical treatment of unicentric plasma cell histological type Castleman's disease].
abstract: BACKGROUND
  Castleman's disease or angiofollicular lymph hyperplasia is a rare disease with two identified clinical forms. Unicentric or localized form is characterized by isolated growth of lymph nodes, most often in mediastinum, and multicentric form is expressed as systemic disease with spread lymphadenopathy, organomegaly and presence of general symptoms of the disease. Histological types are hyalovascular, plasma-cell and transitive (mixed) cell.
  
  
  METHODS
  This case report shows a woman, 59 years old, with unicentric form of plasma-cell type of Castleman's disease. Unicentric form is usually shown as hyalovascular histological type, extremely rare as plasma-cell type, and transitive (mixed) cell type was never described in literature as localized clinical form. The disease was manifested with chest pain, loss of body weight, exhaustion and weakness of legs. Further diagnostic procedures found the presence of enlarged lymph nodes paratracheally right, in a close contact with vena cava superior. The disease was confirmed by histopathological analysis of bioptated mediastinal lymph node after mediastinoscopy. Surgical treatment included extirpation of enlarged lymph nodes. After the regular postoperative condition, a full therapy effect was confirmed.
  
  
  CONCLUSIONS
  Unicentric form of Castleman's disease is expressed with enlarged lymph nodes on predilected places, usually in mediastinum. Surgical treatment is best method for the management of the disease and brings a full recovery of patient.
authors: Vojnomedicinska akademija, Klinika za grudnu hirurgiju, Beograd, Srbija.
authors: Nebojsa
authors: N
authors: Marić
authors: Vojkan
authors: V
authors: Stanić
authors: Vlado
authors: V
authors: Cvijanović
authors: Aleksandar
authors: A
authors: Ristanović
authors: Snezana
authors: S
authors: Kovacević
authors: Zarko
authors: Z
authors: Krivokapić
authors: Olga Tasić
authors: OT
authors: Radić
mesh_terms: D005871:Castleman Disease / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008875:Middle Aged