title: Coartemether induced oxidative and hepatic damage in Plasmodium berghei strain Anka infected mice.
abstract: This study investigated the effect of coartemether on antioxidant and hepatotoxic biomarkers in Plasmodium berghei infected mice. Erythrocyte, hepatic and renal superoxide dismutase (2.71 ± 0.51; 1.96 ± 0.87; 2.84 ± 0.22 Units/mg protein respectively) and catalase (4.10 ± 0.10; 8.25 ± 1.24; 6.28 ± 0.11 Units/mg protein respectively) activities were significantly (p < 0.05) elevated in "parasitized and treated" (PnT) animals. Renal glutathione level (19.02 ± 0.20 μg/mL) was elevated in PnT animals. Glutathione S-transferase and malondialdehyde levels in hepatic (8.76 ± 0.49 μmol/min/mg; 527.23 ± 24.56 mmol/dL) and renal (3.35 ± 0.30 μmol/min/mg; 464.42 ± 59.13 mmol/dL) tissues were significantly high (p < 0.05) in coartemether-treated animals alone. Plasma aspartate transferase (9.45 ± 3.59 U/L) and alanine transferase (5.78 ± 2.36 U/L) were high in PnT animals. Therefore, data indicates that in the presence of P. berghei, coartemether could alter the antioxidant status and induce hepatotoxic damage in mice.
authors: Department of Chemical and Environmental Sciences, School of Science and Technology, Babcock University, Ilisan-Remo, Ikeja, P.M.B. 21244, Ogun State, Nigeria. anyasorgodswill@yahoo.co.uk
authors: God'swill Nduka
authors: GN
authors: Anyasor
authors: Isaac Olayinka
authors: IO
authors: Oyewole
authors: Kayode Olushola
authors: KO
authors: Ogunwenmo
authors: Adegoke
authors: A
authors: Ayowole
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use / Q000633:toxicity*; D000077611:Artemether, Lumefantrine Drug Combination; D037621:Artemisinins / Q000627:therapeutic use / Q000633:toxicity*; D015415:Biomarkers / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D004338:Drug Combinations; D004983:Ethanolamines / Q000627:therapeutic use / Q000633:toxicity*; D005449:Fluorenes / Q000627:therapeutic use / Q000633:toxicity*; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008288:Malaria / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D018384:Oxidative Stress; D010962:Plasmodium berghei; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000962:Antimalarials; D000077611:Artemether, Lumefantrine Drug Combination; D037621:Artemisinins; D015415:Biomarkers; D004338:Drug Combinations; D004983:Ethanolamines; D005449:Fluorenes; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione