title: Successful treatment of terbinafine in a case of sporotrichosis.
abstract: Sporotrichosis is a chronic subacute infection caused by fungi belonging to the Sporothrix Complex. In the present clinical case, nasal sporotrichosis was treated with potassium iodide. This was unsuccessful, and the treatment was restarted with a combination of potassium iodide and itraconazole. This however resulted in a further recurrence of the infection. The mycological cultures were tested in vitro for antifungal activity to assist in treatment. Terbinafine, an antifungal drug, produced the best results and was therefore used for the rest of the treatment course, with no recurrence after two years of its completion. In addition, both cultures were compared using RAPD and different fragment patterns were observed. This indicated that the isolates were either different or indicated a microevolutionary process of this microorganism.
authors: Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
authors: Daiane
authors: D
authors: Heidrich
authors: Cheila Denise Ottonelli
authors: CD
authors: Stopiglia
authors: Luciana
authors: L
authors: Senter
authors: Gerson
authors: G
authors: Vetoratto
authors: Patricia
authors: P
authors: Valente
authors: Maria Lúcia
authors: ML
authors: Scroferneker
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000627:therapeutic use*; D009668:Nose Diseases / Q000188:drug therapy* / Q000382:microbiology; D013175:Sporothrix / Q000302:isolation & purification; D013174:Sporotrichosis / Q000188:drug therapy* / Q000382:microbiology; D000077291:Terbinafine
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; D000077291:Terbinafine