title: [Transcatheter arterial chemotherapy with miriplatin for patients with hepatocellular carcinoma and chronic renal failure].
abstract: Miriplatin is a novel lipophilic platinum complex developed to treat hepatocellular carcinoma (HCC). Although HCC patients frequently have coexisting chronic renal failure, there is no reliable data regarding clinical toxicity of miriplatin in HCC patients with chronic renal failure. We retrospectively evaluated the safety and efficacy of transcatheter arterial chemotherapy with miriplatin in 67 HCC patients with chronic renal failure (estimated glomerular filtration rate [GFR] by the Cockcroft-Gault equation <60ml/min). Estimated GFR within 2 months after miriplatin administration did not decrease significantly by the Wilcoxon signed rank test (pretreatment;46ml/min, 1 month;48ml/min;P=0.019, 2 months;45ml/min;P=0.619 [P<0.003 was significant by the Bonferroni correction]). Complete response in terms of tumor necrosis was achieved in 14 of 67 patients and no serious adverse events were observed. These results suggested that transcatheter arterial chemotherapy with miriplatin can be used safely for HCC patients with chronic renal failure.
authors: Deptartment of Hepatology, Toranomon Hospital. norihiro.imai@gmail.com
authors: Norihiro
authors: N
authors: Imai
authors: Kenji
authors: K
authors: Ikeda
authors: Yuya
authors: Y
authors: Seko
authors: Naoki
authors: N
authors: Matsumoto
authors: Yusuke
authors: Y
authors: Kawamura
authors: Tetsuya
authors: T
authors: Hosaka
authors: Masahiro
authors: M
authors: Kobayashi
authors: Satoshi
authors: S
authors: Saitoh
authors: Hitomi
authors: H
authors: Sezaki
authors: Norio
authors: N
authors: Akuta
authors: Fumitaka
authors: F
authors: Suzuki
authors: Yoshiyuki
authors: Y
authors: Suzuki
authors: Yasuji
authors: Y
authors: Arase
authors: Hiromitsu
authors: H
authors: Kumada
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000188:drug therapy*; D002404:Catheterization; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D007676:Kidney Failure, Chronic / Q000150:complications*; D008113:Liver Neoplasms / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; C406530:miriplatin