title: Kjellmaniella crassifolia Miyabe (Gagome) extract modulates intestinal and systemic immune responses.
abstract: Kjellmaniella crassifolia Miyabe (gagome) is a brown alga. Oral gagome administration (oral gagome) resulted in significant upregulation of IL-10 and IFNγ production by Peyer's patch cells. To assess the adjuvant activity of oral gagome, treated mice were subcutaneously injected with ovalbumin (OVA). The production of cytokines from antigen (Ag)-specific T cells in draining lymph nodes (dLN) and their proliferative response were significantly increased as compared with the control group. These enhancements were associated with increased CD44(hi)CD62L(-) activated/memory T cells in dLN as well as upregulation of Ag-specific IgA level in luminal contents. No upregulation of cytokine production by dLN T cells was observed in dectin-1-deficient mice, suggesting that the effect of gagome on cytokine production is largely dependent on the dectin-1 pathway despite its composite constituents. Our findings indicate that gagome is an effective immunomodulator and a potent adjuvant for both the intestinal and the systemic immune response.
authors: Molecular Composite Medicine Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan.
authors: Huimin
authors: H
authors: Yan
authors: Shigeru
authors: S
authors: Kakuta
authors: Masao
authors: M
authors: Nishihara
authors: Masahito
authors: M
authors: Sugi
authors: Yoshiyuki
authors: Y
authors: Adachi
authors: Naohito
authors: N
authors: Ohno
authors: Yoichiro
authors: Y
authors: Iwakura
authors: Noriko M
authors: NM
authors: Tsuji
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D049109:Cell Proliferation; D002478:Cells, Cultured; D016207:Cytokines / Q000032:analysis; D005260:Female; D007113:Immunity, Innate / Q000187:drug effects*; D018928:Immunity, Mucosal / Q000187:drug effects; D007070:Immunoglobulin A / Q000276:immunology; D016753:Interleukin-10 / Q000032:analysis; D007422:Intestines / Q000187:drug effects* / Q000276:immunology; D037181:Lectins, C-Type / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology; D010581:Peyer's Patches / Q000276:immunology; D000459:Phaeophyceae / Q000737:chemistry*; D013601:T-Lymphocytes / Q000276:immunology; D000099181:Dectin-1
chemical_list: D000276:Adjuvants, Immunologic; D016207:Cytokines; D007070:Immunoglobulin A; D016753:Interleukin-10; D037181:Lectins, C-Type; D010047:Ovalbumin; D000099181:Dectin-1