title: [Frontiers in vitamin D; basic research and clinical application. Vitamin D regulation of macrophage -dependent innate immunity].
abstract: Among various pleiotropic actions of vitamin D, its immunomodulatory role has been well recognized for more than 30 years. However, despite the presence of vitamin D receptors in immune cells including lymphocytes and monocytes/macrorphages, the impact of vitamin D system on immune regulation remained unclear. Recently, two key functions of vitamin D : induction of antimicrobial peptides and autophagy in cells of the monocyte/macrophage lineage, have been described, revealing a much clearer picture of the role of vitamin D as an immunomodulator, particularly in innate immunity against pathogens such as Mycobacterium tuberculosis. This review summarizes recent advances in research of vitamin D as a regulator of innate immunity, and clinical trials of vitamin D as a potential anti-infectious agent.
authors: Third Department of Medicine, Teikyo University Chiba Medical Center, Japan.
authors: Daisuke
authors: D
authors: Inoue
mesh_terms: D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase / Q000502:physiology; D000818:Animals; D001343:Autophagy / Q000187:drug effects; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects*; D007155:Immunologic Factors; D008264:Macrophages / Q000276:immunology*; D009169:Mycobacterium tuberculosis / Q000276:immunology; D010281:Parathyroid Hormone / Q000502:physiology; D014807:Vitamin D / Q000494:pharmacology* / Q000502:physiology*
chemical_list: D007155:Immunologic Factors; D010281:Parathyroid Hormone; D014807:Vitamin D; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase