title: Rewind to recover: dedifferentiation after cardiac injury.
abstract: In adult mammals, cardiomyocytes are known to reactivate an embryonic gene-expression program after injury. In this issue of Cell Stem Cell, Kubin et al. (2011) show that oncostatin M regulates this dedifferentiation which, while beneficial for recovery from acute injury, if persistent results in heart failure in both rodents and humans.
authors: Department of Medicine and Department of Cell and Developmental Biology, Institute for Regenerative Medicine, Cardiovascular Institute, Translational Research Center, University of Pennsylvania, Philadelphia, PA 19104-5129, USA. emorrise@mail.med.upenn.edu
authors: Edward E
authors: EE
authors: Morrisey