title: Cervical conization--treatment for cervical intraepithelial neoplasia and carcinoma in situ.
abstract: OBJECTIVE
  Cone biopsy is the best treatment for high-grade premalignant cervical changes. Cervical intraepithelial changes do not show any clinical picture until the process develops into carcinoma.
  
  
  METHODS
  This retrospective study included 395 women who underwent conization at Gynecology and Obstetrics Clinic "Narodni front" during 2009. The chi-square test was used for comparing results.
  
  
  RESULTS
  Pathohistological findings from biospy and conization were identical in 40.50% of patients, in 10.13%, the conization finding was more severe than the biopsy finding, while in 49.37% less severe than the biopsy finding. Resection margins status analysis showed that 12.66% of cones were positive. Comparison between cones with positive margins and operative techniques did not show any statistically significant difference; 64% of women with positive margins were over the age of 35.
  
  
  CONCLUSIONS
  Operative conization techniques are equally represented. However in women over the age of 40 scalpel excision methods are recommended. In women over the age of 45 there is a statistically significant increase in the risk for positive resection margin with CIN3 and glandular lesions.
authors: Department for Early Cancer Detection, Gynecology and Obstetrics Clinic "Narodni front", School of Medicine, Belgrade University, Belgrade, Serbia.
authors: Z
authors: Z
authors: Perisic
authors: M
authors: M
authors: Perisic
authors: V P
authors: VP
authors: Karapandzic
authors: M
authors: M
authors: Vasiljevic
authors: S J
authors: SJ
authors: Raznatovic
authors: A
authors: A
authors: Jurisic
mesh_terms: D000328:Adult; D001706:Biopsy; D002278:Carcinoma in Situ / Q000473:pathology* / Q000601:surgery; D002584:Cervix Uteri / Q000473:pathology*; D019092:Conization; D005260:Female; D006801:Humans; D012189:Retrospective Studies; D002578:Uterine Cervical Dysplasia / Q000473:pathology* / Q000601:surgery