title: Evaluation of antidiabetic and antioxidant potential of lupeol in experimental hyperglycaemia.
abstract: Oxidative stress, produced under diabetic conditions, is a possible cause of various forms of tissue damage. The concentrations of antioxidant enzymes in cases of diabetes are significantly decreased, with a concomitant increase in lipid peroxidation. In this study, lupeol, a phytoconstituent from Solanum xanthocarpum, is shown to suppress the progression of diabetes after 21 days. Lupeol treatment caused decreases in glycated haemoglobin, serum glucose and nitric oxide, with a concomitant increase in serum insulin level. Furthermore, treatment with lupeol also increased antioxidant levels, with a decrease in the level of thiobarbituric acid-reactive oxygen species.
authors: Reproductive Physiology Section, Centre for Advanced Studies, Department of Zoology , University of Rajasthan, Jaipur 302004, India. gupta_rs@hotmail.com
authors: Rajnish
authors: R
authors: Gupta
authors: Anil Kumar
authors: AK
authors: Sharma
authors: M C
authors: MC
authors: Sharma
authors: M P
authors: MP
authors: Dobhal
authors: R S
authors: RS
authors: Gupta
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D053978:Pentacyclic Triterpenes / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D000094042:Lupanes
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D053978:Pentacyclic Triterpenes; C010480:lupeol; D000094042:Lupanes