title: Phosphoric acid functionalized mesoporous organo-silica (EPO) as the adsorbent for in situ enrichment and isotope labeling of endogenous phosphopeptides.
abstract: Ti(4+)-EPO nanoparticles were adopted as the adsorbent for in situ solid phase enrichment and isotope labeling of endogenous phosphopeptides, which has great potential application in high-throughput analyses of biological samples for screening and discovery of disease-specific biomarkers.
authors: CAS Key Laboratory of Separation Sciences for Analytical Chemistry, National Chromatographic R&A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Dalian 116023, China.
authors: Hongqiang
authors: H
authors: Qin
authors: Fangjun
authors: F
authors: Wang
authors: Peiyuan
authors: P
authors: Wang
authors: Liang
authors: L
authors: Zhao
authors: Jun
authors: J
authors: Zhu
authors: Qihua
authors: Q
authors: Yang
authors: Ren'an
authors: R
authors: Wu
authors: Mingliang
authors: M
authors: Ye
authors: Hanfa
authors: H
authors: Zou
mesh_terms: D000327:Adsorption; D001483:Base Sequence; D007553:Isotope Labeling / Q000379:methods; D008969:Molecular Sequence Data; D053758:Nanoparticles / Q000737:chemistry*; D010748:Phosphopeptides / Q000737:chemistry* / Q000302:isolation & purification; D010756:Phosphoric Acids / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods; D014025:Titanium / Q000737:chemistry*
chemical_list: D010748:Phosphopeptides; D010756:Phosphoric Acids; D012822:Silicon Dioxide; D014025:Titanium; C030242:phosphoric acid