title: Pd(II)-catalyzed enantioselective C-H activation of cyclopropanes.
abstract: Systematic ligand development has led to the identification of novel mono-N-protected amino acid ligands for Pd(II)-catalyzed enantioselective C-H activation of cyclopropanes. A diverse range of organoboron reagents can be used as coupling partners, and the reaction proceeds under mild conditions. These results provide a new retrosynthetic disconnection for the construction of enantioenriched cis-substituted cyclopropanecarboxylic acids.
authors: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
authors: Masayuki
authors: M
authors: Wasa
authors: Keary M
authors: KM
authors: Engle
authors: David W
authors: DW
authors: Lin
authors: Eun Jeong
authors: EJ
authors: Yoo
authors: Jin-Quan
authors: JQ
authors: Yu
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D002384:Catalysis; D003521:Cyclopropanes / Q000138:chemical synthesis / Q000737:chemistry*; D008024:Ligands; D010165:Palladium / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D003521:Cyclopropanes; D008024:Ligands; C015766:cyclopropanecarboxylic acid; D010165:Palladium