title: [Beta-lactamases...until when?].
abstract: Due to environmental factors and wide use of antimicrobials, only those species that developed their own defense mechanisms shall survive. Enzymatic inactivation is the most common cause of antibiotic resistance. Beta-lactamase production has been described early after the discovery of penicillin and it continues to diversify being now able to inactivate even the most advanced antibiotic. The association with other resistance determinants makes the infection with this kind of bacteria a major therapeutic problem.
authors: Universitatea de Medicină şi Farmacie "Gr. T. Popa" Iaşi, Facultatea de Medicina, Spitalul Clinic de Boli infecţioase Iaşi.
authors: Carmen
authors: C
authors: Dorobăţ
authors: G
authors: G
authors: Dorobăţ
authors: Carmen
authors: C
authors: Manciuc
authors: A
authors: A
authors: Vâţă
mesh_terms: D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects / Q000201:enzymology*; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D001426:Bacterial Proteins / Q000378:metabolism; D002510:Cephalosporinase / Q000378:metabolism; D006801:Humans; D008826:Microbial Sensitivity Tests; D010405:Penicillinase / Q000378:metabolism; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D002510:Cephalosporinase; D010405:Penicillinase; D001618:beta-Lactamases; C063912:carbapenemase; C108449:oxacillinase