title: Mycobacteria and biological response modifiers: two sides of the relationship.
abstract: With increasing use of biological response modifiers (BRMs) for various systemic inflammatory diseases there is a need to be vigilant about complications with the use of these therapies. It is important to have appropriate screening for the infections in patients requiring BRMs. However, many studies have reported benefits of certain BRMs in the treatment of infections such as tuberculosis as adjuncts. Continued research and technical advances in immunogenetics helps understand complex mechanisms in the usage of the BRMs. This article summarizes the different aspects of the relationship between mycobacterial infections and the use of various BRMs for inflammatory conditions.
authors: Division of Infectious Diseases, Southern Illinois University School of Medicine, Springfield, IL 62794, USA. vsundareshan@siumed.edu
authors: Vidya
authors: V
authors: Sundareshan
authors: Jignesh
authors: J
authors: Modi
authors: Nancy Misri
authors: NM
authors: Khardori
mesh_terms: D016207:Cytokines / Q000276:immunology; D054884:Host-Pathogen Interactions; D006801:Humans; D007155:Immunologic Factors / Q000009:adverse effects / Q000627:therapeutic use*; D007249:Inflammation / Q000276:immunology; D008264:Macrophages / Q000382:microbiology; D009164:Mycobacterium Infections / Q000188:drug therapy* / Q000276:immunology
chemical_list: D016207:Cytokines; D007155:Immunologic Factors