title: Oxidants, metabolism, and stem cell biology.
abstract: Adult stem cells persist throughout the lifetime of the organism and may therefore require specific mechanisms to limit the effects of chronic oxidative stress. Recently, several instructive genetic mouse models have demonstrated the unique susceptibility of stem cells to perturbations in metabolic or redox homeostasis. These results have implications not only for stem cell biology but also suggest a mechanistic link between intracellular oxidants and the decline in regenerative function that occurs as a normal consequence of aging.
authors: Center for Molecular Medicine, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA.
authors: Jie
authors: J
authors: Liu
authors: Liu
authors: L
authors: Cao
authors: Toren
authors: T
authors: Finkel
mesh_terms: D000818:Animals; D002468:Cell Physiological Phenomena; D006801:Humans; D016877:Oxidants / Q000378:metabolism*; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism*
chemical_list: D016877:Oxidants