title: Endothelial factors after selective retrograde coronary venous bypass under different pressures.
abstract: BACKGROUND
  Selective retrograde coronary venous bypass (SRCVB) may be a promising treatment for patients with advanced coronary artery disease (CAD). The aim of this study is to investigate the effect of SRCVB on plasma endothelial factor levels in dog myocardial ischemic model, and explore the possible mechanisms.
  
  
  METHODS
  24 crossbreed dogs were randomly divided into three groups: (1) control group; (2) SRCVB group with 60 mmHg perfusion pressure; (3) SRCVB group with 90 mmHg perfusion pressure. The posterior descending coronary artery (PDA) was ligated in all groups, and SRCVB was performed in the last two groups. The levels of plasma nitric oxide (NO) and endothelin (ET) at different time points were determined in each group. In SRCVB groups, ink and imaging agent were injected to the heart through SVG graft for assessment of vein perfusion.
  
  
  RESULTS
  At the acute period, there were significant increase in the plasma levels of NO and decrease in ET in SRCVB 90 mmHg group compared with the control (P < 0. 01), and a further improvement were found in SRCVB 60 mmHg group (P < 0. 01). The ink or imaging agent was found in the myocardial tissue and flowed back to right atrium through contralateral coronary vein.
  
  
  CONCLUSIONS
  SRCVB with low level of perfusion pressure could provide effective perfusion for ischemic myocardium and alleviate the myocardial endothelial cell injury. It may be a new therapeutic strategy for severe CAD.
authors: Department of Cardiac Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China.
authors: Ye
authors: Y
authors: Zhao
authors: Tian-Xiang
authors: TX
authors: Gu
authors: Guang-Wei
authors: GW
authors: Zhang
authors: En-Yi
authors: EY
authors: Shi
authors: Lei
authors: L
authors: Yu
authors: Chun
authors: C
authors: Wang
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000601:surgery; D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography; D004195:Disease Models, Animal; D004285:Dogs; D042783:Endothelial Cells / Q000378:metabolism*; D016232:Endothelins / Q000097:blood*; D005260:Female; D008297:Male; D017202:Myocardial Ischemia / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D009204:Myocardial Revascularization / Q000379:methods*; D009569:Nitric Oxide / Q000097:blood*; D010477:Perfusion / Q000379:methods*; D011312:Pressure; D012501:Saphenous Vein / Q000637:transplantation; D013997:Time Factors; D014680:Veins / Q000601:surgery
chemical_list: D015415:Biomarkers; D016232:Endothelins; D009569:Nitric Oxide