title: Treatment outcome of Paederus dermatitis due to rove beetles (Coleoptera: Staphylinidae) on guinea pigs.
abstract: Linear dermatitis (or dermatitis linearis, DL) is a skin blistering inflammatory   lesion caused by exposure to the pederin toxin from rove beetles. Although it is prevalent   in many countries of the Middle East region, this is not a notifiable disease. In recent   years, a number of clinical symptoms outbreaks of DL has been reported from a few   neighboring countries of Iran, but no report of experimental treatment among small   laboratory rodents is known. This is a prerequisite to ascertain the nature of the best   treatment strategy in cases of infestation with these beetles, as it occurs among local   settlers during hot seasons in certain parts of the southern Iranian province of Fars.   Live Paederus beetles were collected, identified to species level, sexed apart and partly   processed to obtain their hemolymph toxin pederin in ethanol for dermal application on   guinea pigs. Two Paederus species were found. Paederus ilsae (Bernhauer) (Coleoptera:   Staphylinidae) was more abundant than P. iliensis (Coiffait). Recovery from DL due to   live P. ilsae beetles was quicker and less complex than that of pederin in ethanol on   guinea pigs. The application of potassium permanganate with calamine to heal DL was   also more effective than fluocinolone treatment. This topical corticosteroid is thus   considered less able to avert the cytotoxic action of pederin on the skin of guinea pigs   than the antipruritic and cleansing agents. It seems likely that fluocinolone has certain   effects which delays the recovery period for the treated skin.
authors: Department of Medical Entomology, School of Health and Nutrition, Research Centre for Health Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
authors: M R
authors: MR
authors: Fakoorziba
authors: F
authors: F
authors: Eghbal
authors: K
authors: K
authors: Azizi
authors: M D
authors: MD
authors: Moemenbellah-Fard
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D001517:Coleoptera / Q000145:classification / Q000472:pathogenicity*; D003877:Dermatitis, Contact / Q000188:drug therapy*; D004195:Disease Models, Animal; D004338:Drug Combinations; D005260:Female; D005290:Ferric Compounds / Q000008:administration & dosage; D005446:Fluocinolone Acetonide / Q000008:administration & dosage / Q000031:analogs & derivatives; D006168:Guinea Pigs; D007299:Insect Bites and Stings / Q000150:complications; D007492:Iran; D008297:Male; D011196:Potassium Permanganate / Q000008:administration & dosage; D011714:Pyrans / Q000302:isolation & purification / Q000633:toxicity*; D016896:Treatment Outcome; D015034:Zinc Oxide / Q000008:administration & dosage
chemical_list: D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D005290:Ferric Compounds; D011714:Pyrans; D011196:Potassium Permanganate; D005446:Fluocinolone Acetonide; C020241:calamine (pharmaceutical preparation); C100127:pederin; C035394:fluocinolone; D015034:Zinc Oxide