title: Complexation and conjugation approaches to evaluate siRNA delivery using cationic, hydrophobic and amphiphilic peptides.
abstract: In this study, we used solid phase synthesis to prepare three kinds of peptides and then formulated their peptide-siRNA complexes and peptide-siRNA conjugates. Both the complexation and conjugation systems were nontoxic and allowed the delivery of siRNA into the cytoplasm without the need for any transfection agents and with subsequent inhibition of gene expression.
authors: Department of Chemistry, Division of IBB, Pohang University of Science and Technology, Pohang, 790-784, Republic of Korea.
authors: Jung Woo
authors: JW
authors: Park
authors: Eun-Kyoung
authors: EK
authors: Bang
authors: Eun Mi
authors: EM
authors: Jeon
authors: Byeang Hyean
authors: BH
authors: Kim
mesh_terms: D002412:Cations; D009682:Magnetic Resonance Spectroscopy; D010455:Peptides / Q000008:administration & dosage / Q000235:genetics*; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000235:genetics; D016339:Spectrometry, Mass, Fast Atom Bombardment
chemical_list: D002412:Cations; D010455:Peptides; D034741:RNA, Small Interfering