title: From toxins targeting ligand gated ion channels to therapeutic molecules.
abstract: Ligand-gated ion channels (LGIC) play a central role in inter-cellular communication. This key function has two consequences: (i) these receptor channels are major targets for drug discovery because of their potential involvement in numerous human brain diseases; (ii) they are often found to be the target of plant and animal toxins. Together this makes toxin/receptor interactions important to drug discovery projects. Therefore, toxins acting on LGIC are presented and their current/potential therapeutic uses highlighted.
authors: Department of Biology, Faculty of Sciences, Arak University, Iran. nasiripour_a@yahoo.com
authors: Adak
authors: A
authors: Nasiripourdori
authors: Valérie
authors: V
authors: Taly
authors: Thomas
authors: T
authors: Grutter
authors: Antoine
authors: A
authors: Taly
mesh_terms: D000818:Animals; D001665:Binding Sites; D004305:Dose-Response Relationship, Drug; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D058446:Ligand-Gated Ion Channels / Q000819:agonists* / Q000037:antagonists & inhibitors* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D011485:Protein Binding; D014118:Toxins, Biological / Q000737:chemistry / Q000494:pharmacology* / Q000506:poisoning
chemical_list: D058446:Ligand-Gated Ion Channels; D014118:Toxins, Biological