title: Limited sampling strategies for the estimation of atazanavir daily exposure in HIV-infected patients.
abstract: Stepwise multiple regression analyses were applied to 44 atazanavir pharmacokinetic profiles from 44 HIV-1 infected patients concomitantly treated with raltegravir with the goal of identifying limited sampling strategies for the prediction of drug AUC(0-12) . Atazanavir trough-based equations failed to reliably predict daily drug exposure in patients with low drug bioavailability. Conversely, different algorithms based on few samples and associated with good correlation, acceptable bias and imprecision with the measured atazanavir AUC(0-12)  were identified. These models could be used to predict atazanavir exposure for clinic or research purposes.
authors: CNR Institute of Neuroscience and Unit of Clinical Pharmacology, Department of Clinical Sciences, Luigi Sacco University Hospital, Università di Milano, via GB Grassi 74, 20157 Milano, Italy. cattaneo.dario@hsacco.it
authors: Dario
authors: D
authors: Cattaneo
authors: Diego
authors: D
authors: Ripamonti
authors: Sara
authors: S
authors: Baldelli
authors: Valeria
authors: V
authors: Cozzi
authors: Serena
authors: S
authors: Fucile
authors: Emilio
authors: E
authors: Clementi
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D019540:Area Under Curve; D000069446:Atazanavir Sulfate; D001682:Biological Availability; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism*; D017320:HIV Protease Inhibitors / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D015497:HIV-1; D006801:Humans; D009842:Oligopeptides / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011725:Pyridines / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011760:Pyrrolidinones / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000068898:Raltegravir Potassium; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors; D009842:Oligopeptides; D011725:Pyridines; D011760:Pyrrolidinones; D000068898:Raltegravir Potassium; D000069446:Atazanavir Sulfate