title: Hypocellular acute myeloid leukemia in adults: analysis of the clinical outcome of 123 patients.
abstract: BACKGROUND
  The hypocellular variant of acute myeloid leukemia accounts for less than 10% of all cases of adult acute myeloid leukemia. It is defined by having less than 20 percent of cellular bone marrow in a biopsy at presentation. It is unclear in the literature whether the outcome of hypocellular acute myeloid leukemia differs from that of non-hypocellular acute myeloid leukemia.
  
  
  METHODS
  We retrospectively analyzed all the cases reported to be hypocellular acute myeloid leukemia between 2000 and 2009. A second pathology review was conducted and the diagnosis was confirmed in all cases.
  
  
  RESULTS
  One hundred twenty-three (9%) patients were identified: patients with hypocellular acute myeloid leukemia were older than those with non-hypocellular acute myeloid leukemia (P=0.009) and more frequently presented with cytopenias (P<0.001). Forty-one patients with hypocellular acute myeloid leukemia had an antecedent hematologic disorder and 11 patients had received prior chemo-radiotherapy for non-hematopoietic neoplasms. On multivariate analysis, overall survival, remission duration and event-free survival were comparable to those of other patients with acute myeloid leukemia.
  
  
  CONCLUSIONS
  The outcome of hypocellular acute myeloid leukemia does not differ from that of non-hypocellular acute myeloid leukemia.
authors: Department of Hematology, Mayo Clinic, Rochester, MN, USA.
authors: Aref
authors: A
authors: Al-Kali
authors: Sergej
authors: S
authors: Konoplev
authors: Erpei
authors: E
authors: Lin
authors: Tapan
authors: T
authors: Kadia
authors: Stefan
authors: S
authors: Faderl
authors: Farhad
authors: F
authors: Ravandi
authors: Mohamad
authors: M
authors: Ayoubi
authors: Mark
authors: M
authors: Brandt
authors: Jorge E
authors: JE
authors: Cortes
authors: Hagop
authors: H
authors: Kantarjian
authors: Gautam
authors: G
authors: Borthakur
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult