title: Arabidopsis calcium-binding mitochondrial carrier proteins as potential facilitators of mitochondrial ATP-import and plastid SAM-import.
abstract: Chloroplasts and mitochondria are central to crucial cellular processes in plants and contribute to a whole range of metabolic pathways. The use of calcium ions as a secondary messenger in and around organelles is increasingly appreciated as an important mediator of plant cell signaling, enabling plants to develop or to acclimatize to changing environmental conditions. Here, we have studied the four calcium-dependent mitochondrial carriers that are encoded in the Arabidopsis genome. An unknown substrate carrier, which was previously found to localize to chloroplasts, is proposed to present a calcium-dependent S-adenosyl methionine carrier. For three predicted ATP/phosphate carriers, we present experimental evidence that they can function as mitochondrial ATP-importers.
authors: Department of Biochemistry and Cell Biology, MFPL, University of Vienna, Vienna, Austria.
authors: Simon
authors: S
authors: Stael
authors: Agostinho G
authors: AG
authors: Rocha
authors: Alan J
authors: AJ
authors: Robinson
authors: Przemyslaw
authors: P
authors: Kmiecik
authors: Ute C
authors: UC
authors: Vothknecht
authors: Markus
authors: M
authors: Teige
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism*; D000595:Amino Acid Sequence; D017360:Arabidopsis / Q000166:cytology* / Q000235:genetics / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling; D002135:Calcium-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D020832:EF Hand Motifs; D018745:Genome, Plant / Q000235:genetics; D008928:Mitochondria / Q000378:metabolism*; D008969:Molecular Sequence Data; D010802:Phylogeny; D018087:Plastids / Q000378:metabolism*; D021381:Protein Transport; D012436:S-Adenosylmethionine / Q000378:metabolism*; D013379:Substrate Specificity
chemical_list: C120492:APC1 protein, Arabidopsis; D029681:Arabidopsis Proteins; D002135:Calcium-Binding Proteins; D012436:S-Adenosylmethionine; D000255:Adenosine Triphosphate; D002118:Calcium