title: Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment.
abstract: Standard pharmacologic closure of the patent ductus arteriosus currently involves the administration of 1 of 2 cyclooxygenase inhibitors: either indomethacin or ibuprofen. However, both of these drugs can be associated with potentially significant adverse effects. We present here the cases of 5 preterm infants (gestational age: 26-32 weeks; postnatal age: 3-35 days) with large, hemodynamically significant patent ductus arteriosus who had either failed or had contraindications to ibuprofen therapy. Each of these infants was treated with off-label oral paracetamol (15 mg/kg per dose every 6 hours). Ductal closure was achieved within 48 hours in all the treated infants. No toxicity was observed.
authors: Department of Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel. cathy@cc.huji.ac.il
authors: Cathy
authors: C
authors: Hammerman
authors: Alona
authors: A
authors: Bin-Nun
authors: Einat
authors: E
authors: Markovitch
authors: Michael S
authors: MS
authors: Schimmel
authors: Michael
authors: M
authors: Kaplan
authors: Daniel
authors: D
authors: Fink
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use*; D004374:Ductus Arteriosus, Patent / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male
chemical_list: D000082:Acetaminophen