title: Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans.
abstract: Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here, we treated 11 healthy, obese men with placebo and 150 mg/day resveratrol (resVida) in a randomized double-blind crossover study for 30 days. Resveratrol significantly reduced sleeping and resting metabolic rate. In muscle, resveratrol activated AMPK, increased SIRT1 and PGC-1α protein levels, increased citrate synthase activity without change in mitochondrial content, and improved muscle mitochondrial respiration on a fatty acid-derived substrate. Furthermore, resveratrol elevated intramyocellular lipid levels and decreased intrahepatic lipid content, circulating glucose, triglycerides, alanine-aminotransferase, and inflammation markers. Systolic blood pressure dropped and HOMA index improved after resveratrol. In the postprandial state, adipose tissue lipolysis and plasma fatty acid and glycerol decreased. In conclusion, we demonstrate that 30 days of resveratrol supplementation induces metabolic changes in obese humans, mimicking the effects of calorie restriction.
authors: Top Institute Food and Nutrition (TIFN), 6700 Wageningen, The Netherlands.|Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, 6200 Maastricht, The Netherlands.
authors: Silvie
authors: S
authors: Timmers
authors: Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, 6200 Maastricht, The Netherlands.
authors: Ellen
authors: E
authors: Konings
authors: Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, 6200 Maastricht, The Netherlands.
authors: Lena
authors: L
authors: Bilet
authors: Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
authors: Riekelt H
authors: RH
authors: Houtkooper
authors: Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, 6200 Maastricht, The Netherlands.
authors: Tineke
authors: T
authors: van de Weijer
authors: Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, 6200 Maastricht, The Netherlands.
authors: Gijs H
authors: GH
authors: Goossens
authors: Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, 6200 Maastricht, The Netherlands.
authors: Joris
authors: J
authors: Hoeks
authors: Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, 6200 Maastricht, The Netherlands.
authors: Sophie
authors: S
authors: van der Krieken
authors: Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
authors: Dongryeol
authors: D
authors: Ryu
authors: Nutrition, Metabolism, and Genomics Group, Division of Human Nutrition, Wageningen University, 6700 Wageningen, The Netherlands.
authors: Sander
authors: S
authors: Kersten
authors: Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, 6200 Maastricht, The Netherlands.
authors: Esther
authors: E
authors: Moonen-Kornips
authors: Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, 6200 Maastricht, The Netherlands.
authors: Matthijs K C
authors: MKC
authors: Hesselink
authors: DSM Nutritional Products Ltd., 4303 Kaiseraugst, Switzerland.
authors: Iris
authors: I
authors: Kunz
authors: Radiology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, 6200 Maastricht, The Netherlands.
authors: Vera B
authors: VB
authors: Schrauwen-Hinderling
authors: Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, 6200 Maastricht, The Netherlands.
authors: Ellen
authors: E
authors: Blaak
authors: Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
authors: Johan
authors: J
authors: Auwerx
authors: Top Institute Food and Nutrition (TIFN), 6700 Wageningen, The Netherlands.|Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, 6200 Maastricht, The Netherlands.
authors: Patrick
authors: P
authors: Schrauwen
mesh_terms: D000091162:AMP-Activated Protein Kinase Kinases; D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000410:Alanine Transaminase / Q000032:analysis; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D031204:Caloric Restriction / Q000379:methods*; D002950:Citrate (si)-Synthase / Q000096:biosynthesis; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004734:Energy Metabolism / Q000187:drug effects; D005227:Fatty Acids / Q000378:metabolism; D005990:Glycerol / Q000097:blood; D006360:Heat-Shock Proteins / Q000096:biosynthesis; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D008931:Mitochondria, Muscle / Q000187:drug effects* / Q000378:metabolism; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism; D009426:Netherlands; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D011494:Protein Kinases / Q000096:biosynthesis; D000077185:Resveratrol; D056564:Sirtuin 1 / Q000096:biosynthesis; D013267:Stilbenes / Q000008:administration & dosage / Q000627:therapeutic use*; D013557:Switzerland; D014157:Transcription Factors / Q000096:biosynthesis; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D005227:Fatty Acids; D006360:Heat-Shock Proteins; C486497:PPARGC1A protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D013267:Stilbenes; D014157:Transcription Factors; D014280:Triglycerides; D002950:Citrate (si)-Synthase; D000410:Alanine Transaminase; D011494:Protein Kinases; D000091162:AMP-Activated Protein Kinase Kinases; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D005990:Glycerol; D000077185:Resveratrol