title: Effects of bromopride on abdominal wall healing with induced peritoneal sepsis after segmental colectomy and colonic anastomosis in rats.
abstract: OBJECTIVE
  Evaluate the effects of bromopride on abdominal wall healing of rats with induced peritoneal sepsis after segmental colectomy and colonic anastomosis.
  
  
  METHODS
  Forty rats underwent sectioning of the left colon and end-to-end anastomosis and were divided into two groups of 20 animals for the administration of bromopride (bromopride group - B) or saline solution (control group - C). Each group was divided into subgroups of 10 animals each to be killed on the third (GB3 and GC3) or seventh postoperative day (GB7 and GC7). It was analyzed the following characteristics: breaking strength of the abdominal wall's wound; surgical and histopathological features of the abdominal wall; and clinical features of the rats.
  
  
  RESULTS
  There was no difference between the groups in relation to the weight of the rats and the breaking strength of the abdominal wall's wound. The GB7 group presented less edema and less quantity of fibrin during histopathological evaluation compared to the GC7 group.
  
  
  CONCLUSIONS
  Bromopride did not have harmful effects on the healing of abdominal wall in rats.
authors: School of Medicine, UnB, Brasilia, DF, Brazil.
authors: Marcos Vinícius Melo de
authors: MV
authors: Oliveira
authors: Alexandre Malta
authors: AM
authors: Brandão
authors: Pedro Henrique Alves de
authors: PH
authors: Morais
authors: Naiara Galvão da
authors: NG
authors: Silva
authors: Silvana Marques e
authors: SM
authors: Silva
authors: Fabiana Pirani
authors: FP
authors: Carneiro
authors: João Batista de
authors: JB
authors: Sousa
mesh_terms: D034861:Abdominal Wall / Q000601:surgery*; D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D000932:Antiemetics / Q000494:pharmacology*; D003082:Colectomy; D008297:Male; D008787:Metoclopramide / Q000031:analogs & derivatives* / Q000494:pharmacology; D010538:Peritonitis / Q000150:complications* / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D018805:Sepsis / Q000150:complications* / Q000503:physiopathology; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000932:Antiemetics; C013855:bromopride; D008787:Metoclopramide