title: Iron-catalysed, hydride-mediated reductive cross-coupling of vinyl halides and Grignard reagents.
abstract: An iron-catalysed, hydride-mediated reductive cross-coupling reaction has been developed for the preparation of alkanes. Using a bench-stable iron(II) pre-catalyst, reductive cross-coupling of vinyl iodides, bromides and chlorides with aryl- and alkyl Grignard reagents successfully gave the products of formal sp(3)-sp(3) cross-coupling reactions.
authors: School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS.
authors: Bryden A F
authors: BA
authors: Le Bailly
authors: Mark D
authors: MD
authors: Greenhalgh
authors: Stephen P
authors: SP
authors: Thomas
mesh_terms: D000473:Alkanes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D007501:Iron / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D014752:Vinyl Chloride / Q000737:chemistry*; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: D000473:Alkanes; D009942:Organometallic Compounds; D014753:Vinyl Compounds; C569210:vinyl iodide; C003763:vinyl bromide; D007501:Iron; D014752:Vinyl Chloride