title: Association of interferon-gamma gene polymorphisms with susceptibility to oral lichen planus in the Thai population.
abstract: OBJECTIVE
  Interferon-gamma (IFN-γ) is highly expressed in oral lichen planus (OLP). The IFN-γ (+874 in intron 1, rs2430561) TT genotype, which has been reported to be associated with high IFN-γ production, was hypothesized to be associated with susceptibility to OLP in the Thai population.
  
  
  METHODS
  Genomic DNA samples from 74 OLP and 268 healthy controls were evaluated for IFN-γ polymorphisms by polymerase chain reaction with sequence-specific primers (PCR-SSP) and direct sequencing method.
  
  
  RESULTS
  The T allele was significantly associated with an increased risk of OLP development as compared to the A allele (OR=1.76, P=0.004; P(c)=0.02). The effect of the T allele was similar to an autosomal recessive disorder; the presence of TT genotype (when compared to AA and AT) conferred an OR of 2.61, P=0.008; P(c)=0.04.
  
  
  CONCLUSIONS
  We found an association between IFN-γ +874A/T polymorphism and susceptibility to OLP. However, an association study utilising a larger sample size and patients from other races apart from the Asian population should be performed to further verify these findings.
authors: Department of Microbiology, Kasetsart University, Chatuchak, Bangkok 10900, Thailand.
authors: Ingorn
authors: I
authors: Kimkong
authors: Jeerawat
authors: J
authors: Nakkuntod
authors: Pimpayao
authors: P
authors: Sodsai
authors: Nattiya
authors: N
authors: Hirankarn
authors: Nakarin
authors: N
authors: Kitkumthorn
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D017676:Lichen Planus, Oral / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D013785:Thailand
chemical_list: D007371:Interferon-gamma