title: Pulmonary pleomorphic carcinoma producing granulocyte-macrophage colony-stimulating factor: report of a case.
abstract: We report a case of lung cancer producing granulocyte-macrophage colony-stimulating factor (GM-CSF). The patient, a 55-year-old woman, was found to have leukocytosis (leukocytes 28.8 × 10(3)/mm3) with eosinophilia (eosinophils 24.5%) without any evidence of infection or allergy. The serum concentration of GM-CSF was elevated to 44 pg/ml (normal range <2.0 pg/ml), which might have induced the leukocytosis and eosinophilia. We performed left pneumonectomy and diagnosed a pleomorphic carcinoma with p-T2bN0M0, based on histological examination of the resected tumor. Immunohistochemical examination revealed GM-CSF. The serum level of GM-CSF decreased to within the normal range 8 days after surgery. At the time of writing, 16 months after the surgery, she was alive without disease. To our knowledge, this represents the first case report of a GM-CSF-producing tumor effectively treated by surgical resection.
authors: Department of Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. toshinori710@yahoo.co.jp
authors: Toshinori
authors: T
authors: Fukutomi
authors: Mitsutomo
authors: M
authors: Kohno
authors: Yotaro
authors: Y
authors: Izumi
authors: Masazumi
authors: M
authors: Watanabe
authors: Yuichiro
authors: Y
authors: Hayashi
authors: Hiroaki
authors: H
authors: Nomori
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D008875:Middle Aged; D011013:Pneumonectomy
chemical_list: D014408:Biomarkers, Tumor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor