title: Ghrelin-mediated sympathoinhibition and suppression of inflammation in sepsis.
abstract: Sepsis, a systemic inflammatory response to infection, continues to carry a high mortality despite advances in critical care medicine. Elevated sympathetic nerve activity in sepsis has been shown to contribute to early hepatocellular dysfunction and subsequently multiple organ failure, resulting in a poor prognosis, especially in the elderly. Thus, suppression of sympathetic nerve activity represents a novel therapeutic option for sepsis. Ghrelin is a 28-amino acid peptide shown to inhibit sympathetic nerve activity and inflammation in animal models of tissue injury. Age-related ghrelin hyporesponsiveness has also been shown to exacerbate sepsis. However, the mechanistic relationship between ghrelin-mediated sympathoinhibition and suppression of inflammation remains poorly understood. This review assesses the therapeutic potential of ghrelin in sepsis in the context of the neuroanatomical and molecular basis of ghrelin-mediated suppression of inflammation through inhibition of central sympathetic outflow.
authors: Elmezzi Graduate School of Molecular Medicine, Hofstra North Shore-LIJ Medical School, Manhasset, New York, USA.
authors: Cletus
authors: C
authors: Cheyuo
authors: Asha
authors: A
authors: Jacob
authors: Ping
authors: P
authors: Wang
mesh_terms: D000375:Aging; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002395:Catecholamines / Q000378:metabolism; D004351:Drug Resistance; D054439:Ghrelin / Q000627:therapeutic use*; D006801:Humans; D058990:Molecular Targeted Therapy; D009102:Multiple Organ Failure / Q000209:etiology / Q000517:prevention & control; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D018805:Sepsis / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D013565:Sympatholytics / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002395:Catecholamines; D054439:Ghrelin; D013565:Sympatholytics