title: Association of mannose-binding lectin gene polymorphism with tuberculosis susceptibility and sputum conversion time.
abstract: Mannose-binding lectin (MBL) plays an important role in innate immunity. The effect of low MBL levels producing variants of MBL2 gene on tuberculosis (TB) has been controversial with some studies reporting it to confer protection against the disease, whereas others estimating a susceptibility relation. Other than conducting a case-control study to evaluate the role of MBL A/B polymorphism on TB, we conducted a longitudinal study to check whether this MBL variant can influence the host response to Mycobacterium tuberculosis infection. A total of 357 TB patients (286 pulmonary TB, 71 extrapulmonary (EP) TB) and 392 healthy controls belonging to same ethnicity were included in the study. We found the mutant allele 'B' allele confers a protective role against TB in our study population. This effect was absent in EP patients. On stratification on the basis of sex, the protective role of the 'B' allele was found to be limited to females only and males reported no significant difference. No effect of MBL A/B polymorphism on sputum conversion time was reported. We conclude that MBL 'B' allele is associated with protection against TB, but no influence was found on sputum conversion rate.
authors: Department of Biotechnology, Panjab University, Chandigarh, India.
authors: N
authors: N
authors: Singla
authors: D
authors: D
authors: Gupta
authors: A
authors: A
authors: Joshi
authors: N
authors: N
authors: Batra
authors: J
authors: J
authors: Singh
authors: Niti
authors: N
authors: Birbian
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D037601:Mannose-Binding Lectin / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000276:immunology / Q000472:pathogenicity; D011110:Polymorphism, Genetic; D013183:Sputum / Q000276:immunology / Q000382:microbiology*; D013997:Time Factors; D014376:Tuberculosis / Q000235:genetics* / Q000276:immunology / Q000382:microbiology; D055815:Young Adult
chemical_list: C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin