title: Association study of candidate gene polymorphisms and obesity in a young Mexican-American population from South Texas.
abstract: OBJECTIVE
  Obesity is increasingly a health problem and a risk factor for diabetes in young Mexican-American populations. Genetic association studies in older, mostly non-Hispanic populations have reported that polymorphisms in the candidate genes HSD11B1, CRP, ADIPOQ, PPARG, ANKK1, ABCC8 and SERPINF1 are associated with obesity or diabetes. We analyzed the polymorphisms rs846910, rs1205, rs1501299, rs1801282, rs1800497, rs757110 and rs1136287 in these candidate genes, for association with obesity and metabolic traits in a young Mexican-American population from south Texas.
  
  
  METHODS
  Genotyping of the seven common SNPs were performed by allelic discrimination assays in 448 unrelated Mexican Americans (median age = 16 years) from south Texas. χ(2) tests and regression analyses using additive models were used for genetic association analyses adjusting for covariates; p values were corrected for multiple testing by permutation analyses.
  
  
  RESULTS
  rs1800497 (ANKK1) shows association with waist circumference (p = 0.009) and retains the association (p = 0.03) after permutation testing. Analysis of metabolic quantitative traits shows that rs846910 (HSD11B1) was associated with HOMA-IR (p = 0.04) and triglycerides (p = 0.03), and rs1205 (CRP) with HOMA-IR (p = 0.03) and fasting glucose levels (p = 0.007). However, the quantitative traits associations are not maintained after permutation analysis. None of the other SNPs in this study showed associations with obesity or metabolic traits in this young Mexican-American population.
  
  
  CONCLUSIONS
  We report a potential association between rs1800497 (linked to changes in brain dopamine receptor levels) and central obesity in a young Mexican-American population.
authors: Department of Biological Sciences and Center of Biomedical Studies, University of Texas School of Public Health, Brownsville, TX 78520, USA.
authors: Jorge
authors: J
authors: Duran-Gonzalez
authors: Ixiu
authors: I
authors: Ortiz
authors: Enrique
authors: E
authors: Gonzales
authors: Nicole
authors: N
authors: Ruiz
authors: Manti
authors: M
authors: Ortiz
authors: Arthur
authors: A
authors: Gonzalez
authors: Edna K
authors: EK
authors: Sanchez
authors: Eugenia
authors: E
authors: Curet
authors: Susan
authors: S
authors: Fisher-Hoch
authors: Anne
authors: A
authors: Rentfro
authors: Huiqi
authors: H
authors: Qu
authors: Saraswathy
authors: S
authors: Nair
mesh_terms: D000293:Adolescent; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D020022:Genetic Predisposition to Disease; D006801:Humans; D017058:Mexican Americans / Q000235:genetics*; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D013781:Texas
chemical_list: D004247:DNA