title: Role of interleukin-10 in breast cancer.
abstract: Cytokines are low molecular weight regulatory proteins or glycoprotein that modulates the intensity and duration of immune response by stimulating or inhibiting the activation, proliferation, and/or differentiation of target cells. Different cytokines are known to have diverse role in breast cancer initiation and progression. Interleukin-10 (IL-10), a pleiotropic anti-inflammatory cytokine, induces immunosuppression and assists in escape from tumor immune surveillance. Like several other cytokines, IL-10 also can exert dual proliferative and inhibitory effect on breast tumor cells indicating a complex role of IL-10 in breast cancer initiation and progression. In this review, we tried to put together a comprehensive current view on significance of IL-10 in promotion, inhibition, and importance as prognosticator in breast cancer based on in vitro, in vivo, and clinical evidences. For literature collection, we conducted PubMed search with keywords "IL-10" and "breast cancer".
authors: Endocrinology Division, CSIR-Central Drug Research Institute, MG Road, Lucknow, UP 226001, India.
authors: Hamidullah
authors: Bendangla
authors: B
authors: Changkija
authors: Rituraj
authors: R
authors: Konwar
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D001943:Breast Neoplasms / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D016207:Cytokines / Q000378:metabolism; D005260:Female; D006801:Humans; D007107:Immune System / Q000378:metabolism / Q000473:pathology; D016753:Interleukin-10 / Q000235:genetics / Q000378:metabolism*; D011110:Polymorphism, Genetic; D011379:Prognosis; D015398:Signal Transduction
chemical_list: D014408:Biomarkers, Tumor; D016207:Cytokines; C508609:IL10 protein, human; D016753:Interleukin-10