title: Intrauterine lidocaine infusion for pain management during outpatient transcervical tubal sterilization: a randomized controlled trial.
abstract: BACKGROUND
  The study was conducted to examine the effects of a 4% intrauterine lidocaine infusion on patient-perceived pain during transcervical sterilization.
  
  
  METHODS
  This was a randomized, double-blind, placebo-controlled trial. Subjects received standard premedication with 800 mg ibuprofen, 2 mg lorazepam, a 10-mL 1% lidocaine paracervical block and transcervical instillation of 5 mL of either 4% lidocaine or saline 3 min prior to insertion of the hysteroscope. Subjects completed a series of 100-mm visual analog scales to measure their perceived pain at set time points during and after the procedure. Serum lidocaine levels were obtained in a subset of subjects.
  
  
  RESULTS
  Pain scores at all evaluation points did not significantly differ between groups (lidocaine n=29, saline n=29). Mean lidocaine levels did not differ between groups, and no subject demonstrated symptoms of lidocaine toxicity. The highest serum lidocaine level (4022 ng/mL) occurred 20 min after infusion in a lidocaine-treated subject.
  
  
  CONCLUSIONS
  Intrauterine lidocaine prior to outpatient transcervical sterilization does not decrease pain.
authors: Department of Obstetrics and Gynecology, The Ohio State University, Columbus, OH 43210, USA. Michelle.Isley@osumc.edu
authors: Michelle M
authors: MM
authors: Isley
authors: Jeffrey T
authors: JT
authors: Jensen
authors: Mark D
authors: MD
authors: Nichols
authors: Amy
authors: A
authors: Lehman
authors: Paula
authors: P
authors: Bednarek
authors: Alison
authors: A
authors: Edelman
mesh_terms: D000328:Adult; D000779:Anesthetics, Local / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D008012:Lidocaine / Q000008:administration & dosage*; D059408:Pain Management / Q000379:methods; D010147:Pain Measurement; D013246:Sterilization, Tubal
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine