title: Clinical parameters predicting survival duration after hepatectomy for intrahepatic cholangiocarcinoma.
abstract: BACKGROUND
  Currently, the most effective treatment for intrahepatic cholangiocarcinoma (ICC) is complete hepatic tumour excision.
  
  
  OBJECTIVE
  To identify the clinical parameters associated with survival duration for ICC patients following hepatectomy, and to construct a mathematical model for predicting survival duration.
  
  
  METHODS
  Demographic data and clinical variables for 102 patients diagnosed with ICC, who underwent exploratory laparotomy at a single centre from July 1998 to December 2000 and were followed for an average of 24 months, were collected in 2011. Patients were randomly assigned into training (n=76) and validation (n=26) groups. Univariate and multivariate analyses were performed to identify factors associated with posthepatectomy survival duration.
  
  
  RESULTS
  Univariate analysis revealed that more than three lymph node metastases, a serum carbohydrate antigen 19-9 level greater than 37 U⁄mL, stage IVa tumours, and intra- or perihepatic metastases were significantly associated with decreased survival duration. Curative resection was significantly associated with increased survival duration. A mathematical model incorporating parameters of age, sex, metastatic lymph node number, curative surgery, carbohydrate antigen 19-9 concentration, alpha-fetoprotein concentration, hepatitis B, TNM stage and tumour differentiation was constructed for predicting survival duration. For a survival duration of less than one year, the model exhibited 93.8% sensitivity, 92.3% total accuracy and a positive predictive value of 93.8%; for a survival duration of one to three years, the corresponding values were 80.0%, 69.2% and 57.1%, respectively.
  
  
  CONCLUSIONS
  The mathematical model presented in the current report should prove to be useful in the clinical setting for predicting the extent to which curative resection affects the survival of ICC patients, and for selecting optimal postoperative treatment strategies.
authors: Department of Laparoscopy, Second Military Medical University, Shaghai, People's Republic of China. jiang_beige@yahoo.com.cn
authors: Bei-ge
authors: BG
authors: Jiang
authors: Rui-liang
authors: RL
authors: Ge
authors: Liang-liang
authors: LL
authors: Sun
authors: Ming
authors: M
authors: Zong
authors: Gong-tian
authors: GT
authors: Wei
authors: Yong-jie
authors: YJ
authors: Zhang
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001650:Bile Duct Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery; D001653:Bile Ducts, Intrahepatic / Q000473:pathology / Q000601:surgery; D002681:China; D018281:Cholangiocarcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery; D005260:Female; D006498:Hepatectomy / Q000379:methods / Q000592:standards; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011182:Postoperative Care / Q000379:methods / Q000592:standards; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012737:Sex Factors; D015996:Survival Rate; D016896:Treatment Outcome