title: A case of multicentric reticulohistiocytosis responsive to azathioprine in a patient with no underlying malignancy.
abstract: Multicentric reticulohistiocytosis (MRH), a rare histiocytic systemic condition characterized by mutilating arthritis and multiple cutaneous nodules, has been associated with malignancy including that of the breast, thyroid and colon. An unsubstantiated link with infectious agents such as mycobacterium tuberculosis has been described. Many treatments have been used with varying success. We describe the case of a 60-year-old man with MRH and no underlying malignancy who initially responded well to azathioprine and whose disease recurred upon cessation. A second course of azathioprine administered in conjunction with antituberculous treatment resulted in disease control. Broader associations and features of this rare disease are discussed.
authors: Department of Dermatology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia. alice_rudd@hotmail.com
authors: Alice
authors: A
authors: Rudd
authors: Con
authors: C
authors: Dolianitis
authors: George
authors: G
authors: Varigos
authors: Anne
authors: A
authors: Howard
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use*; D015616:Histiocytosis, Non-Langerhans-Cell / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007538:Isoniazid / Q000627:therapeutic use; D055985:Latent Tuberculosis / Q000150:complications / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D012008:Recurrence
chemical_list: D000995:Antitubercular Agents; D007166:Immunosuppressive Agents; D001379:Azathioprine; D007538:Isoniazid