title: Independent regulation of Na+ and K+ balance by the kidney.
abstract: The understanding of the independent regulation of sodium and potassium by the kidney has remained elusive. Recent evidence now points to dissimilar regulatory mechanisms in ion handling, dependent on the presence of either aldosterone alone or angiotensin II with aldosterone among other factors. This review summarizes past and present information in an attempt to reconcile the current concepts of differential regulation of sodium and potassium balance through the with-no-lysine (K) kinase (WNK) system and the previous knowledge regarding ion transport mechanisms in the distal nephron.
authors: Molecular Physiology Unit, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Instituto Nacional de Cardiología Ignacio Chávez, and Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.
authors: María
authors: M
authors: Castañeda-Bueno
authors: Juan Pablo
authors: JP
authors: Arroyo
authors: Gerardo
authors: G
authors: Gamba
mesh_terms: D053503:Epithelial Sodium Channels / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D017136:Ion Transport; D007668:Kidney / Q000378:metabolism*; D015778:Minor Histocompatibility Antigens; D009399:Nephrons / Q000378:metabolism; D011188:Potassium / Q000378:metabolism*; D024661:Potassium Channels, Inwardly Rectifying / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*; D012982:Sodium, Dietary / Q000378:metabolism; D000076204:WNK Lysine-Deficient Protein Kinase 1
chemical_list: D053503:Epithelial Sodium Channels; D047908:Intracellular Signaling Peptides and Proteins; C086989:KCNJ1 protein, human; D015778:Minor Histocompatibility Antigens; D024661:Potassium Channels, Inwardly Rectifying; D012982:Sodium, Dietary; D012964:Sodium; D017346:Protein Serine-Threonine Kinases; D000076204:WNK Lysine-Deficient Protein Kinase 1; C498743:WNK1 protein, human; D011188:Potassium