title: Evaluation of new chalcone derivatives as polyphenol oxidase inhibitors.
abstract: A newly series of 4-(phenylurenyl)chalcone (4a-j) and 4'-(phenylurenyl/thiourenyl)chalcone (9a-l) derivatives were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. Tyrosinase has been purified from banana on an affinity gel comprised of Sepharose 4B-l-tyrosine-p-aminobenzoic acid. The result showed that 4a-j inhibited the PPO enzyme activity. Conversely, 9a-h and 9i-l showed activator effect on tyrosinase enzyme activity.
authors: Department of Chemistry, Faculty of Art and Sciences, Sakarya University, Sakarya 54140, Turkey.
authors: Fatih
authors: F
authors: Sonmez
authors: Sedat
authors: S
authors: Sevmezler
authors: Alparslan
authors: A
authors: Atahan
authors: Mustafa
authors: M
authors: Ceylan
authors: Dudu
authors: D
authors: Demir
authors: Nahit
authors: N
authors: Gencer
authors: Oktay
authors: O
authors: Arslan
authors: Mustafa
authors: M
authors: Kucukislamoglu
mesh_terms: D004156:Catechol Oxidase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002599:Chalcone / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D007700:Kinetics; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors / Q000378:metabolism; D028521:Musa / Q000201:enzymology
chemical_list: D004791:Enzyme Inhibitors; D002599:Chalcone; D004156:Catechol Oxidase; D014442:Monophenol Monooxygenase