title: [Influence of inoculum size on MICs for methicillin-susceptible Staphylococcus aureus and methicillin-resistant Staphylococcus aureus].
abstract: Using 49 clinical methicillin-susceptible Staphylococcus aureus isolates (MSSA) and 54 clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates, we examined the change of MIC using five different inocula (2.5-4 x 10(2) cfu/spot-2.5-4 x 10(6) cfu/spot). We found the big change of the MIC with the increase of the inoculum size in ampicillin against MSSA, and the change was small in cefazolin, meropenem, ciprofloxacin. For anti-MRSA antibiotics, we found the small change with the increase of the inoculums size in vancomycin and arbekacin, and the middle change in teicoplanin and linezolid against MSSA and MRSA. The data from this study suggest that in serious and high inocula infections caused by S. aureus, the presence of an inoculum effect should be considered in curing.
authors: Faculty of Medicine and Biosystemic Science, Graduate School of Medical Science, Kyushu University.
authors: Noriko
authors: N
authors: Miyake
authors: Masako
authors: M
authors: Kadowaki
authors: Yoriko
authors: Y
authors: Sato
authors: Yoshihiro
authors: Y
authors: Eriguchi
authors: Yoji
authors: Y
authors: Nagasaki
authors: Yukiko
authors: Y
authors: Harada
authors: Yujiro
authors: Y
authors: Uchida
authors: Nobuyuki
authors: N
authors: Shimono
mesh_terms: D000081:Acetamides / Q000494:pharmacology*; D000667:Ampicillin / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001431:Bacteriological Techniques / Q000379:methods*; D002437:Cefazolin / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D003982:Dibekacin / Q000031:analogs & derivatives* / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D000069349:Linezolid; D000077731:Meropenem; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests / Q000379:methods*; D023303:Oxazolidinones / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D017334:Teicoplanin / Q000494:pharmacology*; D013845:Thienamycins / Q000494:pharmacology*; D014640:Vancomycin / Q000494:pharmacology*
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D013845:Thienamycins; D003982:Dibekacin; D002939:Ciprofloxacin; D017334:Teicoplanin; D014640:Vancomycin; D000667:Ampicillin; D000077731:Meropenem; C031986:arbekacin; D002437:Cefazolin; D000069349:Linezolid