title: Body mass index and CD4+ T-lymphocyte recovery in HIV-infected men with viral suppression on antiretroviral therapy.
abstract: OBJECTIVE
  To better characterize the relationship between body mass index (BMI) and CD4+ T-lymphocyte recovery in HIV disease.
  
  
  METHODS
  We analyzed the association between baseline BMI and CD4+ T-lymphocyte increases, as well as the association between BMI and immune activation (CD38 and HLA-DR co-expression on CD4+ and CD8+ T-lymphocytes), in male HIV-infected patients who achieved viral suppression on antiretroviral therapy (ART).
  
  
  RESULTS
  Baseline BMI predicted change in CD4+ T-lymphocyte count at weeks 96 ( P = .03, n = 461) and 144 ( P = .005, n = 357) but not at week 48 ( P = .38, n = 558). Relative to men with a normal BMI, overweight and obese men had increases at week 144 that were 35 and 113 cells/ mm3 higher, respectively, while underweight men had CD4+ T-lymphocyte increases that were 94 cells/mm3 lower. No significant correlations between baseline BMI and cellular immune activation were seen.
  
  
  CONCLUSIONS
  BMI predicts CD4+ T-lymphocyte gains in men started on ART.
authors: Division of Infectious Diseases and HIV Medicine, Drexel University College of Medicine, Philadelphia, PA, USA. Bpalermo@drexelmed.edu
authors: Brandon
authors: B
authors: Palermo
authors: Ronald J
authors: RJ
authors: Bosch
authors: Kara
authors: K
authors: Bennett
authors: Jeffrey M
authors: JM
authors: Jacobson
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D015992:Body Mass Index; D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D006801:Humans; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged
chemical_list: D044966:Anti-Retroviral Agents; D020738:Leptin