title: Effects of erdosteine on hemostasis: an experimental study.
abstract: OBJECTIVE
  In this study, the effects of erdosteine (ED) on the platelet function and coagulation were investigated in adult rats.
  
  
  METHODS
  Twenty-eight male Wistar albino rats were divided into four groups. The control rats in group I (n = 7) were given only 0.5 cc of normal saline daily through oral gavage. Group II (n = 7) rats were administered 3 mg/kg ED through oral gavage for 3 days; while group III (n = 7) rats were given 10 mg/kg ED through oral gavage for 3 days; and group IV (n = 7) rats were administered 30 mg/kg ED through oral gavage for 3 days. Prothrombin time (PT), activated prothromboplastin time (aPTT), international normalized ratio (INR), coagulation factors and complete blood counts were measured from the blood drawn.
  
  
  RESULTS
  There were a lot of differences between ED groups and control group, and among ED groups. The found differences were level of PT, aPTT, INR, coagulation factors, and number of platelets.
  
  
  CONCLUSIONS
  We consider that ED which is used as a mucolytic agent in child clinics may affect hemostasis and coagulation in a dose-dependent manner. ED should be used carefully by the patients with coagulation disorders, since there is no information available in the package insert and literature screening regarding the effect of ED.
authors: Department of Pediatrics, School of Medicine, Mustafa Kemal University, Hatay, Turkey. drtutanc@hotmail.com
authors: M
authors: M
authors: Tutanc
authors: V
authors: V
authors: Arica
authors: S
authors: S
authors: Motor
authors: F
authors: F
authors: Basarslan
authors: E S
authors: ES
authors: Erden
authors: O H
authors: OH
authors: Ozturk
authors: I
authors: I
authors: Zararsiz
authors: M
authors: M
authors: Aydin
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001792:Blood Platelets / Q000187:drug effects*; D005100:Expectorants / Q000494:pharmacology*; D006487:Hemostasis / Q000187:drug effects; D019934:International Normalized Ratio; D008297:Male; D010314:Partial Thromboplastin Time; D010976:Platelet Count; D011517:Prothrombin Time; D051381:Rats; D017208:Rats, Wistar; D013864:Thioglycolates / Q000494:pharmacology*; D013876:Thiophenes / Q000494:pharmacology*
chemical_list: D005100:Expectorants; D013864:Thioglycolates; D013876:Thiophenes; C048498:erdosteine