title: Characterization of Th1- and Th2-type immune response in human multidrug-resistant tuberculosis.
abstract: Multidrug-resistant tuberculosis (MDR-TB) has become a lethal global threat. Insights into the immune regulation of MDR-TB are urgently needed for the development of new treatments; however, the T cell response to an MDR-TB infection in human remains unclear. In the present study, the proportion of Th1 and Th2 cell subsets and the level of related T cell subset cytokines in peripheral blood were investigated. We detected that an MDR-TB infection resulted in suppressed Th1 and Th2 cell activation, which was more remarkable in patients with MDR-TB than that in drug-sensitive tuberculosis (DS-TB) sufferers when compared to healthy controls (HCs). In addition, MDR-TB infection down-regulated the expression of IFN-γ, IL-2, and IL-10, and up-regulated IL-4, IL-6, and TNF-α expression. Our data suggest that the disturbance between protective and pathogenic effects induced by the immunosuppression of Th1- and Th2-type responses is a substantial characteristic of MDR-TB infections.
authors: Department of Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors: Q
authors: Q
authors: Tan
authors: W P
authors: WP
authors: Xie
authors: R
authors: R
authors: Min
authors: G Q
authors: GQ
authors: Dai
authors: C-C
authors: CC
authors: Xu
authors: H Q
authors: HQ
authors: Pan
authors: C D
authors: CD
authors: Miao
authors: Z
authors: Z
authors: Yang
authors: W G
authors: WG
authors: Xu
authors: H
authors: H
authors: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001769:Blood / Q000276:immunology; D016207:Cytokines / Q000378:metabolism; D005260:Female; D006801:Humans; D007108:Immune Tolerance; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*; D018088:Tuberculosis, Multidrug-Resistant / Q000276:immunology*; D055815:Young Adult
chemical_list: D016207:Cytokines