title: Highly efficient synthesis of quinoxalinone-N-oxide via tandem nitrosation/aerobic oxidative C-N bond formation.
abstract: An efficient method for constructing quinoxalinone-N-oxides from cyanoacetanilides has been developed. This transformation can be achieved using inexpensive reagents and molecular oxygen under mild conditions, thus offering a practical pathway to quinoxalinone-containing pharmaceuticals such as ataquimast and opaviraline.
authors: Faculty of Pharmaceutical Sciences, Mukogawa Women's University, 11-68 Koshien Kyubancho, Nishinomiya 663-8179, Hyogo, Japan. ykoba@mukogawa-u.ac.jp
authors: Yusuke
authors: Y
authors: Kobayashi
authors: Mami
authors: M
authors: Kuroda
authors: Natsuki
authors: N
authors: Toba
authors: Mari
authors: M
authors: Okada
authors: Rie
authors: R
authors: Tanaka
authors: Tetsutaro
authors: T
authors: Kimachi
mesh_terms: D000083:Acetanilides / Q000737:chemistry*; D002384:Catalysis; D002625:Chemistry, Organic / Q000191:economics / Q000379:methods; D003500:Cyclization; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010087:Oxides / Q000138:chemical synthesis* / Q000737:chemistry; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000083:Acetanilides; D010087:Oxides; D011810:Quinoxalines; C050119:4-cyanoacetanilide