title: Variants of the adiponectin and adiponectin receptor-1 genes and posttransplantation diabetes mellitus in renal allograft recipients.
abstract: BACKGROUND
  Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients. Adiponectin (ADIPOQ) and adiponectin receptor-1 (ADIPOR1) gene polymorphisms have been associated with type 2 diabetes. However, it is unknown whether these polymorphisms are also risk factors for PTDM.
  
  
  OBJECTIVE
  We investigated the association between PTDM and single-nucleotide polymorphisms of ADIPOQ and ADIPOR1 in a cohort of renal allograft recipients.
  
  
  METHODS
  Five hundred seventy-five patients (367 men and 208 women) who received kidney transplants between 1989 and 2007, without a history of diabetes and with a pretransplant fasting glucose concentration less than 5.5 mmol/liter. Patients were followed up for a median 10 yr. Genotypes included single-nucleotide polymorphisms of the following: ADIPOQ rs266729, rs822395, rs822396, rs2241766, and rs1501299 and ADIPOR1 rs2232853, rs12733285, and rs1342387.
  
  
  RESULTS
  TT-homozygotes in ADIPOQ rs1501299 [hazard ratio (HR) = 1.70, P = 0.032] had greater risk of PTDM after adjusting for age, sex, amount of weight gain, and type of immunosuppressant. There was a significant interaction between sex and ADIPOQ rs1501299 genotype (P = 0.037). In men, but not in women, TT-homozygotes in ADIPOQ rs1501299 were more likely to develop PTDM than the wild GG-homozygotes (HR = 2.50, P = 0.002), whereas GT-heterozygotes had nonsignificantly elevated risk (HR = 1.41, P = 0.128).
  
  
  CONCLUSIONS
  Genetic variation in ADIPOQ rs1501299 is associated with PTDM in a sex-specific manner.
authors: Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, 330, Brookline Avenue, ST 816, Boston, Massachusetts 02215, USA. edgo@yuhs.ac
authors: Eun Seok
authors: ES
authors: Kang
authors: Faidon
authors: F
authors: Magkos
authors: Beom Seok
authors: BS
authors: Kim
authors: Rihong
authors: R
authors: Zhai
authors: Li
authors: L
authors: Su
authors: Yu Seun
authors: YS
authors: Kim
authors: David C
authors: DC
authors: Christiani
authors: Hyun Chul
authors: HC
authors: Lee
authors: Christos S
authors: CS
authors: Mantzoros
mesh_terms: D052242:Adiponectin / Q000235:genetics; D000328:Adult; D003920:Diabetes Mellitus / Q000209:etiology* / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000502:physiology; D054419:Receptors, Adiponectin / Q000235:genetics*; D012737:Sex Factors; D014184:Transplantation, Homologous
chemical_list: C499918:ADIPOQ protein, human; C475418:ADIPOR1 protein, human; D052242:Adiponectin; D054419:Receptors, Adiponectin