title: [Toxic cause febrile neutropenia].
abstract: Agranulocytosis is an acute disease with severe leucopenia, especially with low neutrophils, elements with an essential role in the organism's defense. It is more frequent at adult age (between 30 to 70 years of age) especially in women. We present the case of a 84 years old patient that, following passive exposure to pesticides, develops a severe neutropenia with a fast response to the administration of Methylprednisolone and granulocyte colony-stimulating factor (G-CSF-Filgrastim 48MIU/0.8mL/day, for three days). The diagnostic certainty was set by the bone marrow puncture which excluded a possible aleukemic acute leukemia or a myelodysplastic syndrome.
authors: Universitatea de Medicină şi Farmacie "Gr. T. Popa" Iaşi, Facultatea de Medicină.
authors: Gina
authors: G
authors: Constantinescu
authors: Laura-Elena
authors: LE
authors: Creţu
authors: G C
authors: GC
authors: Cuzincu
authors: Andra-Iuliana
authors: AI
authors: Loghin
authors: Oana-Gabriela
authors: OG
authors: Girigan
authors: V C-tin
authors: VC
authors: Radu
authors: B
authors: B
authors: Alexandroaie
mesh_terms: D000369:Aged, 80 and over; D001856:Bone Marrow Examination; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D004781:Environmental Exposure / Q000009:adverse effects*; D005334:Fever / Q000209:etiology; D005938:Glucocorticoids / Q000627:therapeutic use; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009503:Neutropenia / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D010575:Pesticides / Q000633:toxicity*; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D010575:Pesticides; D016179:Granulocyte Colony-Stimulating Factor; D008775:Methylprednisolone