title: Association of IFNGR2 gene polymorphisms with pulmonary tuberculosis among the Vietnamese.
abstract: Interferon-γ (IFN-γ) is a key molecule of T helper 1 (Th1)-immune response against tuberculosis (TB), and rare genetic defects of IFN-γ receptors cause disseminated mycobacterial infection. The aim of the present study was to investigate whether genetic polymorphisms found in the Th1-immune response genes play a role in TB. In our study, DNA samples were collected from two series of cases including 832 patients with new smear-positive TB and 506 unrelated individuals with no history of TB in the general population of Hanoi, Vietnam. Alleles of eight microsatellite markers located around Th1-immune response-related genes and single nucleotide polymorphisms near the promising microsatellites were genotyped. A set of polymorphisms within the interferon gamma receptor 2 gene (IFNGR2) showed a significant association with protection against TB (P = 0.00054). Resistant alleles tend to be less frequently found in younger age at diagnosis (P = 0.011). Luciferase assays revealed high transcriptional activity of the promoter segment in linkage disequilibrium with resistant alleles. We conclude that the polymorphisms of IFNGR2 may confer resistance to the TB development of newly infected individuals. Contribution of the genetic factors to TB appeared to be different depending on age at diagnosis.
authors: Department of Respiratory Diseases, Research Institute, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan.
authors: Minako
authors: M
authors: Hijikata
authors: Junko
authors: J
authors: Shojima
authors: Ikumi
authors: I
authors: Matsushita
authors: Katsushi
authors: K
authors: Tokunaga
authors: Jun
authors: J
authors: Ohashi
authors: Nguyen T L
authors: NT
authors: Hang
authors: Toru
authors: T
authors: Horie
authors: Shinsaku
authors: S
authors: Sakurada
authors: Nguyen P
authors: NP
authors: Hoang
authors: Pham H
authors: PH
authors: Thuong
authors: Luu T
authors: LT
authors: Lien
authors: Naoto
authors: N
authors: Keicho
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D044466:Asian People / Q000235:genetics; D060467:Disease Resistance / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D017471:Receptors, Interferon / Q000235:genetics*; D014397:Tuberculosis, Pulmonary / Q000235:genetics*; D014744:Vietnam; D000096743:Interferon gamma Receptor
chemical_list: D017471:Receptors, Interferon; D000096743:Interferon gamma Receptor