title: Entorhinal cortex layer III input to the hippocampus is crucial for temporal association memory.
abstract: Associating temporally discontinuous elements is crucial for the formation of episodic and working memories that depend on the hippocampal-entorhinal network. However, the neural circuits subserving these associations have remained unknown. The layer III inputs of the entorhinal cortex to the hippocampus may contribute to this process. To test this hypothesis, we generated a transgenic mouse in which these inputs are specifically inhibited. The mutant mice displayed significant impairments in spatial working-memory tasks and in the encoding phase of trace fear-conditioning. These results indicate a critical role of the entorhinal cortex layer III inputs to the hippocampus in temporal association memory.
authors: The Picower Institute for Learning and Memory, RIKEN-MIT Center for Neural Circuit Genetics, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors: Junghyup
authors: J
authors: Suh
authors: Alexander J
authors: AJ
authors: Rivest
authors: Toshiaki
authors: T
authors: Nakashiba
authors: Takashi
authors: T
authors: Tominaga
authors: Susumu
authors: S
authors: Tonegawa
mesh_terms: D000818:Animals; D001245:Association Learning; D056547:CA1 Region, Hippocampal / Q000502:physiology; D003213:Conditioning, Psychological; D004558:Electric Stimulation; D018728:Entorhinal Cortex / Q000502:physiology*; D005239:Fear; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D018782:Maze Learning; D008570:Memory, Short-Term; D011939:Mental Recall; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009434:Neural Pathways; D009435:Synaptic Transmission