title: Iron-catalyzed C-H and C-C bond cleavage: a direct approach to amides from simple hydrocarbons.
abstract: Something functional: The title reaction proceeds in the presence of azide and water to deliver amides in high yields, and it can be used in a ring-expansion strategy to generate lactams. A mechanism is proposed based on experimental results. This reaction offers a new approach to functionalizing simple and readily available hydrocarbons. DDQ = 2,3-dichloro-5,6-dicyano-1,4-benzoquinone.
authors: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191, China.
authors: Chong
authors: C
authors: Qin
authors: Wang
authors: W
authors: Zhou
authors: Feng
authors: F
authors: Chen
authors: Yang
authors: Y
authors: Ou
authors: Ning
authors: N
authors: Jiao
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006838:Hydrocarbons / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000577:Amides; D006838:Hydrocarbons; D007501:Iron