title: Immunoglobulin D amyloidosis: a distinct entity.
abstract: IgD monoclonal gammopathies are uncommon. They are seen rarely as a monoclonal gammopathy of undetermined significance and are present in 1%-2% of patients with multiple myeloma. In light-chain amyloidosis, IgD monoclonal proteins are found in ap-proximately 1% of patients. When an IgD monoclonal protein is found, amyloidosis is often omitted from the differential diagnosis. In the present study, we reviewed the natural history of IgD-associated amyloidosis among 53 patients seen over 41 years. The distribution of clinical syndromes suggests that these patients have a lower frequency of renal and cardiac involvement. The overall survival of these patients does not appear to be different from that of patients who have light-chain amyloidosis associated with another monoclonal protein.
authors: Division of Hematology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA. gertz.morie@mayo.edu
authors: Morie A
authors: MA
authors: Gertz
authors: Francis K
authors: FK
authors: Buadi
authors: Suzanne R
authors: SR
authors: Hayman
authors: David
authors: D
authors: Dingli
authors: Angela
authors: A
authors: Dispenzieri
authors: Philip R
authors: PR
authors: Greipp
authors: Shaji K
authors: SK
authors: Kumar
authors: Martha Q
authors: MQ
authors: Lacy
authors: John A
authors: JA
authors: Lust
authors: Nelson
authors: N
authors: Leung
authors: S Vincent
authors: SV
authors: Rajkumar
authors: Stephen J
authors: SJ
authors: Russell
authors: Steven R
authors: SR
authors: Zeldenrust
authors: Joseph R
authors: JR
authors: Mikhael
authors: Vivek
authors: V
authors: Roy
authors: Robert A
authors: RA
authors: Kyle
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000686:Amyloidosis / Q000378:metabolism* / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D007072:Immunoglobulin D / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015996:Survival Rate
chemical_list: D007072:Immunoglobulin D