title: The interaction between MYB proteins and their target DNA binding sites.
abstract: Members of the MYB family of transcription factors are found in all eukaryotic lineages, where they function to regulate either fundamental cellular processes, or specific facets of metabolism or cellular differentiation. MYB transcription factors regulate these processes through modulation of transcription at target genes, to which they bind in a sequence-specific manner. Over the past decades, insights have been gained into the molecular interactions between MYB proteins and their cognate DNA targets. This review focuses on those insights, the emergence of common themes in DNA binding by diverse MYB family members. The review also considers gaps in the current knowledge of MYB-DNA interactions, particularly for plant MYB proteins, and how emerging techniques that examine protein-DNA interactions can fill these gaps.
authors: Centre for the Analysis of Genome Evolution & Function, Department of Cell & Systems Biology, University of Toronto, 25 Willcocks St., Toronto, ON, Canada M5S 3B2. michael.prouse@utoronto.ca
authors: Michael B
authors: MB
authors: Prouse
authors: Malcolm M
authors: MM
authors: Campbell
mesh_terms: D000818:Animals; D017360:Arabidopsis / Q000235:genetics* / Q000378:metabolism; D001665:Binding Sites; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism*; D005786:Gene Expression Regulation; D005810:Multigene Family / Q000235:genetics; D020626:Oncogene Proteins v-myb / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D010802:Phylogeny; D017434:Protein Structure, Tertiary / Q000235:genetics; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics*; D020449:Repetitive Sequences, Amino Acid / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D020626:Oncogene Proteins v-myb; D014157:Transcription Factors