title: Plasma aldosterone levels and development of insulin resistance: prospective study in a general population.
abstract: Aldosterone plays a role in hypertension, and hypertension is prevalent in patients with insulin resistance. Cross-sectional studies have reported that plasma aldosterone levels are higher in patients with insulin resistance. However, it is not known whether plasma aldosterone levels predict the development of insulin resistance. Subjects of the present study were 1235 local residents (490 men and 745 women) who participated in health screenings in Japan in 1999. Plasma aldosterone levels were measured by radioimmunoassay. We investigated the cross-sectional relationship between plasma aldosterone levels and insulin resistance (homeostasis model assessment index ≥1.73 according to the diagnostic criteria used in Japan) in 1088 nondiabetic participants. At the 10-year follow-up, 141 subjects had died, and 260 subjects refused re-examination. We performed a prospective analysis of 564 subjects to predict incident insulin resistance. We found a significant (P<0.001) cross-sectional relationship between plasma aldosterone and homeostasis model assessment index at baseline. In the prospective analysis, a significantly higher (P<0.05) relative risk (1.71 [95% CI: 1.03-2.84]) was observed in the highest tertile versus lowest tertile of plasma aldosterone for the development of insulin resistance, after adjustment for confounding factors. This 10-year prospective study demonstrated that plasma aldosterone levels predicted the development of insulin resistance in a general population.
authors: Division of Cardio-Vascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan.
authors: Eita
authors: E
authors: Kumagai
authors: Hisashi
authors: H
authors: Adachi
authors: David R
authors: DR
authors: Jacobs
authors: Yuji
authors: Y
authors: Hirai
authors: Mika
authors: M
authors: Enomoto
authors: Ako
authors: A
authors: Fukami
authors: Maki
authors: M
authors: Otsuka
authors: Shun-ichi
authors: S
authors: Kumagae
authors: Yasuki
authors: Y
authors: Nanjo
authors: Kuniko
authors: K
authors: Yoshikawa
authors: Eishi
authors: E
authors: Esaki
authors: Kanako
authors: K
authors: Yokoi
authors: Kinuka
authors: K
authors: Ogata
authors: Akiko
authors: A
authors: Kasahara
authors: Eri
authors: E
authors: Tsukagawa
authors: Kyoko
authors: K
authors: Ohbu-Murayama
authors: Tsutomu
authors: T
authors: Imaizumi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000453:epidemiology; D000450:Aldosterone / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000097:blood; D007333:Insulin Resistance; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011187:Posture; D011188:Potassium / Q000097:blood; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology
chemical_list: D001786:Blood Glucose; D000450:Aldosterone; D011188:Potassium