title: Antidepressive and anxiolytic activity of selective estrogen receptor modulators in ovariectomized mice submitted to chronic unpredictable stress.
abstract: Estradiol has antidepressive and anxiolytic actions. However, its therapeutic use is limited by its peripheral effects. Selective estrogen receptor modulators may represent an alternative to estradiol for the treatment of depressive symptoms. Here we report that tamoxifen and raloxifene decrease immobility time in the forced swim test and increases the time spent in open arms in the elevated plus maze in ovariectomized mice submitted to chronic unpredictable stress.
authors: Instituto Cajal, CSIC, E-28002 Madrid, Spain.
authors: Isabel
authors: I
authors: Calmarza-Font
authors: Natalia
authors: N
authors: Lagunas
authors: Luis M
authors: LM
authors: Garcia-Segura
mesh_terms: D000818:Animals; D001007:Anxiety / Q000188:drug therapy* / Q000209:etiology; D003863:Depression / Q000188:drug therapy*; D004195:Disease Models, Animal; D005260:Female; D046353:Immobility Response, Tonic / Q000187:drug effects; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D010052:Ovariectomy; D020849:Raloxifene Hydrochloride / Q000627:therapeutic use*; D020845:Selective Estrogen Receptor Modulators / Q000627:therapeutic use*; D012934:Social Isolation / Q000523:psychology; D013315:Stress, Psychological / Q000150:complications* / Q000188:drug therapy; D013550:Swimming / Q000523:psychology; D013629:Tamoxifen / Q000627:therapeutic use*
chemical_list: D020845:Selective Estrogen Receptor Modulators; D013629:Tamoxifen; D020849:Raloxifene Hydrochloride