title: Gene therapy for lung neoplasms.
abstract: Both advanced-stage lung cancer and malignant pleural mesothelioma are associated with a poor prognosis. Advances in treatment regimens for both diseases have had only a modest effect on their progressive course. Gene therapy for thoracic malignancies represents a novel therapeutic approach and has been evaluated in several clinical trials. Strategies have included induction of apoptosis, tumor suppressor gene replacement, suicide gene expression, cytokine-based therapy, various vaccination approaches, and adoptive transfer of modified immune cells. This review considers the clinical results, limitations, and future directions of gene therapy trials for thoracic malignancies.
authors: Division of Pulmonary, Allergy & Critical Care Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
authors: Anil
authors: A
authors: Vachani
authors: Edmund
authors: E
authors: Moon
authors: Elliot
authors: E
authors: Wakeam
authors: Andrew R
authors: AR
authors: Haas
authors: Daniel H
authors: DH
authors: Sterman
authors: Steven M
authors: SM
authors: Albelda
mesh_terms: D015972:Gene Expression Regulation, Neoplastic; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D008175:Lung Neoplasms / Q000235:genetics / Q000276:immunology / Q000628:therapy*; D008654:Mesothelioma / Q000235:genetics / Q000276:immunology / Q000628:therapy*