title: Establishment of a brain tumor tissue repository in India: maintaining quality standards.
abstract: Tumor tissue repositories (TTRs) play a pivotal role in both basic and translational research by acting as a conduit to facilitate innovative research, thereby providing solutions to treat the incurable disease--'Cancer'. One of the fundamental requirements to achieve this goal would be the acquisition of high quality tumor tissue specimens that are stored in such a manner that its integrity is preserved. Further, a quality system should be in place that assures the compliance of procedures that are the key to a smooth functioning of all the inter-related departments that play a key role in the entire operations. To address this, we have initiated an effort to build a tumor tissue repository of brain tumor tissues in the Southern part of the Indian sub-continent. One of the cardinal features of brain tumors is the heterogeneity, both phenotypically and genotypically. Moreover, significant gaps exist in current understanding of the molecular pathways involved in the genesis, progression, and biological and clinical behavior of brain tumors. We hope that our initiative will provide researchers accessibility to a reserve of high quality tissues in this part of the globe. We have created and validated a complete histology service including tissue processing, embedding, sectioning and H&E staining for fixed tissues, in addition to creating and staining frozen sections. To our knowledge, such a structured initiative to store brain tumor samples is the first of its kind in the India.
authors: ANSA Research Foundation (ARF), #560, 1st Floor, "A" Main, Indiranagar, Bangalore, Karnataka -560 038, India.
authors: Aparna
authors: A
authors: Khanna
authors: Samba Siva
authors: SS
authors: Reddy
authors: Majahar
authors: M
authors: Jan
authors: Swapnil
authors: S
authors: Totey
authors: T Vasudev
authors: TV
authors: Rao
authors: Shailesh A V
authors: SA
authors: Rao
authors: Arun L
authors: AL
authors: Naik
authors: Satish
authors: S
authors: Totey
authors: Neelam K
authors: NK
authors: Venkataramana
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D035843:Biomedical Research / Q000941:ethics / Q000458:organization & administration*; D001932:Brain Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D002648:Child; D015925:Cryopreservation; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D011786:Quality Control; D012333:RNA, Messenger / Q000235:genetics; D012334:RNA, Neoplasm / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013048:Specimen Handling; D014015:Tissue Banks / Q000458:organization & administration* / Q000592:standards*; D014019:Tissue Donors; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D012333:RNA, Messenger; D012334:RNA, Neoplasm