title: How CD95 stimulates invasion.
abstract: CD95 is best known for its capacity to induce apoptosis, but also activates multiple non-apoptotic signalling pathways. In particular, CD95 promotes migration and tissue invasion of apoptosis-resistant cell types, and this plays a central role in inflammation, neurobiology, and tumor biology. CD95 induces invasion by stimulating the expression of extracellular matrix (ECM)-degrading proteases, and by stimulating the formation of actin-driven cell protrusions through Rac and the cofilin pathway. In this review we discuss how CD95-initiated signalling pathways may cooperate to facilitate cell migration and tissue invasion.
authors: Department of Surgery, University Medical Centre, Utrecht, The Netherlands.
authors: Ernst J A
authors: EJ
authors: Steller
authors: Inne H M
authors: IH
authors: Borel Rinkes
authors: Onno
authors: O
authors: Kranenburg
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism; D045744:Cell Line, Tumor; D002465:Cell Movement; D004789:Enzyme Activation; D005109:Extracellular Matrix / Q000378:metabolism; D022001:Focal Adhesions / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D015398:Signal Transduction; D019014:fas Receptor / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D020744:rac GTP-Binding Proteins / Q000378:metabolism
chemical_list: D016023:Integrins; D019014:fas Receptor; D011505:Protein-Tyrosine Kinases; D020744:rac GTP-Binding Proteins