title: [Expressions of integrinalpha2beta1 and CD133 in benign prostatic hyperplasia complicated by prostatitis and their significance].
abstract: OBJECTIVE
  To study the expressions of Integrinalpha2beta1 and CD133 in benign prostatic hyperplasia (BPH) complicated by prostatitis and their significance.
  
  
  METHODS
  Specimens were obtained from 56 BPH patients undergoing transvesical prostatectomy. Paraffin sections of the specimens were subjected to HE staining for pathological examination of inflammatory changes under the light microscope. Twenty-four patients with simple BPH were included in Group A, and the other 32 with BPH complicated with prostatitis in Group B. The expressions of Integrinalpha2beta1 and CD133 in the prostatic tissues of the two groups were determined by immunohistochemistry, Western blotting and IPP6.0 image analysis software.
  
  
  RESULTS
  The expressions of Integrinalpha2beta1 and CD133 were significantly higher in Group B than in A (P < 0.05), and so were the mean relative value of the optical density of Integrinalpha2beta1 (0.29 +/- 0.18 vs 0.04 +/- 0.03) and that of CD133 (0.08 +/- 0.07 vs 0.0020 +/- 0.0018) (P < 0.05).
  
  
  CONCLUSIONS
  Inflammation can up-regulate the expressions of Integrinalpha2beta1 and CD133 in BPH tissue.
authors: Department of Urology, The First Affiliated Hospital of Hebei Northern Institute, Zhangjiakou, Hebei 075000, China. dingqi1020@126.com
authors: Qi
authors: Q
authors: Ding
authors: Wen-long
authors: WL
authors: Miao
authors: Shuo
authors: S
authors: Liu
authors: Ji-wu
authors: JW
authors: Chang
authors: Yu-ming
authors: YM
authors: Yang
mesh_terms: D000071916:AC133 Antigen; D015703:Antigens, CD / Q000378:metabolism*; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D038982:Integrin alpha2beta1 / Q000378:metabolism*; D008297:Male; D010455:Peptides / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D011472:Prostatitis / Q000150:complications / Q000378:metabolism* / Q000473:pathology
chemical_list: D000071916:AC133 Antigen; D015703:Antigens, CD; D006023:Glycoproteins; D038982:Integrin alpha2beta1; C000606023:PROM1 protein, human; D010455:Peptides