title: Ethnic-specific meta-analyses of association between the OPRM1 A118G polymorphism and alcohol dependence among Asians and Caucasians.
abstract: BACKGROUND
  Many studies have investigated the association between the OPRM1 A118G polymorphism (rs1799971) and alcohol dependence, but the results were inconsistent. To better understand this relationship, ethnicity-specific meta-analyses were conducted.
  
  
  METHODS
  We retrieved all eligible studies published up to April 12, 2011 from the PubMed/MEDLINE, EMBASE, and ISI Web of Science databases. Ethnicity-specific meta-analyses were performed using either fixed- or random-effect models as appropriate.
  
  
  RESULTS
  Twelve independent studies with 1900 cases and 2382 controls were included. Five studies were conducted in Asians and seven in Caucasians. Ethnicity-specific meta-analyses revealed that the A118G polymorphism was significantly associated with alcohol dependence risk in Asians (GA vs. AA: odds ratio [OR], 1.73; 95% confidence interval [CI], 1.33-2.25; GA+GG vs. AA: OR, 1.57; 95% CI, 1.22-2.02), but not in Caucasians (GA vs. AA: OR, 1.05; 95% CI, 0.75-1.49; GA+GG vs. AA: OR, 1.11; 95% CI, 0.79-1.55).
  
  
  CONCLUSIONS
  The OPRM1 A118G polymorphism may contribute to the susceptibility of alcohol dependence in Asians but not in Caucasians.
authors: Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
authors: Dingyan
authors: D
authors: Chen
authors: Li
authors: L
authors: Liu
authors: Yang
authors: Y
authors: Xiao
authors: Yuehua
authors: Y
authors: Peng
authors: Chengwu
authors: C
authors: Yang
authors: Zengzhen
authors: Z
authors: Wang
mesh_terms: D000437:Alcoholism / Q000453:epidemiology* / Q000235:genetics*; D000483:Alleles; D044466:Asian People; D016001:Confidence Intervals; D005006:Ethnicity / Q000235:genetics* / Q000706:statistics & numerical data*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D017450:Receptors, Opioid, mu / Q000235:genetics*; D044465:White People
chemical_list: C485764:OPRM1 protein, human; D017450:Receptors, Opioid, mu