title: [Chromosome damage of human bronchial epithelial cells induced by glycidyl methacrylate].
abstract: OBJECTIVE
  To observed the chromosome damage of human bronchial epithelial cells induced by glycidyl methacrylate (GMA).
  
  
  METHODS
  Chromosome aberration analysis of human bronchial epithelial cells treated with GMA at different dosages (4, 8, 12, 16 and 20 microg/ml), times (1, 2 and 3 times), and phases (10th, 30th genetation) was detected.
  
  
  RESULTS
  In the dosages range from 4 to 20 microg/ml, the aberration rates (3%, 6%, 7%, 11% and 14%) were demonstrated increasingly with the increase of exposure doses, and dose-effect relationship was found. Significant differences were observed when treated with GMA three times (6%, 7% and 10%). Structure aberrations were found in the transformed 10th-generation cells, while number aberrations were mainly manifested in the transformed 30th-generation cells.
  
  
  CONCLUSIONS
  The chromosome aberration can be induced by GMA in the human bronchial epithelial cells, from the structure aberration at the beginning to the lack of normal nuclear style.
authors: National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Key Laboratory of Chemical Safety and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China. kylewang@sina.com
authors: Quankai
authors: Q
authors: Wang
authors: Ying
authors: Y
authors: Li
authors: Lin
authors: L
authors: Dong
authors: Min
authors: M
authors: Yang
authors: Jie
authors: J
authors: Hu
authors: Jinxiu
authors: J
authors: Sun
authors: Guangyun
authors: G
authors: Xie
authors: Jianning
authors: J
authors: Xu
mesh_terms: D001980:Bronchi / Q000166:cytology*; D002460:Cell Line; D043171:Chromosomal Instability / Q000187:drug effects; D002869:Chromosome Aberrations / Q000139:chemically induced*; D004847:Epithelial Cells / Q000166:cytology / Q000187:drug effects*; D004852:Epoxy Compounds / Q000633:toxicity*; D006801:Humans; D008689:Methacrylates / Q000633:toxicity*
chemical_list: D004852:Epoxy Compounds; D008689:Methacrylates; C007870:glycidyl methacrylate