title: A new 9-nor-atractylodin from Atractylodes lancea and the antibacterial activity of the atractylodin derivatives.
abstract: A new compound, namely, 9-nor-atractylodin (1) and one known atractylodin (2) were isolated from the rhizomes of Atractylodes lancea. The structural modifications of atractylodin were carried out and a series of atractylodin derivatives (3-10) were obtained. The antibacterial activities of 1-10 were examined against Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Candida albicans. Compounds 4 and 8, which contained the α, β-unsaturated carbonyl fragment, were found to be active against E. coli and S. aureus.
authors: School of Biotechnology and Chemical Engineering, Ningbo Institute of Technology, Zhejiang University; Ningbo, 315100, PR China.
authors: Yanjun
authors: Y
authors: Chen
authors: Yuxue
authors: Y
authors: Wu
authors: Hexiang
authors: H
authors: Wang
authors: Kun
authors: K
authors: Gao
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D031174:Atractylodes / Q000737:chemistry*; D001419:Bacteria / Q000187:drug effects; D002175:Candida / Q000187:drug effects; D005663:Furans / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D005663:Furans; C106914:atractylodin