title: Decreased methylation of the NK3 receptor coding gene (TACR3) after cocaine-induced place preference in marmoset monkeys.
abstract: Epigenetic processes have been implicated in neuronal plasticity following repeated cocaine application. Here we measured DNA methylation at promoter CpG sites of the dopamine transporter (DAT1) and serotonin transporter (SERT) and neurokinin3-receptor (NK3-R)-receptor (TACR3) coding genes in marmoset monkeys after repeated cocaine injections in a conditioned place preference paradigm. We found a decrease in DNA methylation at a specific CpG site in TACR3, but not DAT1 or SERT. Thus, TACR3 is a locus for DNA methylation changes in response to repeated cocaine administration and its establishment as a reinforcer, in support of other evidence implicating the NK3-R in reinforcement- and addiction-related processes.
authors: Department of Pharmaceutical Sciences, University of Brasilia, Brazil .
authors: Marilia
authors: M
authors: Barros
authors: Emma L
authors: EL
authors: Dempster
authors: Nicholas
authors: N
authors: Illott
authors: Soha
authors: S
authors: Chabrawi
authors: Rafael S
authors: RS
authors: Maior
authors: Carlos
authors: C
authors: Tomaz
authors: Maria A De Souza
authors: MA
authors: Silva
authors: Joseph P
authors: JP
authors: Huston
authors: Jonathan
authors: J
authors: Mill
authors: Christian P
authors: CP
authors: Müller
mesh_terms: D000818:Animals; D002144:Callithrix; D003042:Cocaine / Q000494:pharmacology*; D019970:Cocaine-Related Disorders / Q000235:genetics; D003216:Conditioning, Operant / Q000187:drug effects; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism*; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D008745:Methylation / Q000187:drug effects; D018042:Receptors, Neurokinin-3 / Q000235:genetics* / Q000378:metabolism; D012054:Reinforcement, Psychology; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D018765:Dopamine Uptake Inhibitors; D018042:Receptors, Neurokinin-3; D050486:Serotonin Plasma Membrane Transport Proteins; D003042:Cocaine