title: Polymorphisms in apoptosis-related genes and TP53 mutations in non-small cell lung cancer.
abstract: Apoptosis plays an essential role in the elimination of mutated or transformed cells from the body. Therefore, polymorphisms of apoptosis-related genes may lead to an alteration in apoptotic capacity, thereby affecting the occurrence of TP53 mutations in lung cancer. We investigated the relationship between potentially functional polymorphisms of apoptosis-related genes and TP53 mutations in non-small cell lung cancer (NSCLC). Twenty-seven single nucleotide polymorphisms in 20 apoptosis-related genes were genotyped by a sequenome mass spectrometry-based genotyping assay in 173 NSCLCs and the associations with TP53 mutations in the entire coding exons (exons 2-11), including splicing sites of the gene, were analyzed. None of the 27 polymorphisms was significantly associated with the occurrence of TP53 mutations. This suggests that apoptosis-related genes may not play an important role in the occurrence of TP53 mutations in lung cancer.
authors: Department of Biochemistry and Cell Biology, Kyungpook National University School of Medicine, Daegu, Korea.
authors: Eun Young
authors: EY
authors: Bae
authors: Eun Jin
authors: EJ
authors: Lee
authors: Hyo-Gyoung
authors: HG
authors: Kang
authors: Shin Yup
authors: SY
authors: Lee
authors: Gwang
authors: G
authors: Jin
authors: Won Kee
authors: WK
authors: Lee
authors: Jin Eun
authors: JE
authors: Choi
authors: Hyo-Sung
authors: HS
authors: Jeon
authors: Jeong Ok
authors: JO
authors: Lim
authors: Eung Bae
authors: EB
authors: Lee
authors: Jae Yong
authors: JY
authors: Park
mesh_terms: D017209:Apoptosis / Q000235:genetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D004252:DNA Mutational Analysis; D005260:Female; D016158:Genes, p53; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics; D008297:Male; D009154:Mutation; D020641:Polymorphism, Single Nucleotide