title: Efficacy of trabectedin in metastatic solitary fibrous tumor.
abstract: Solitary fibrous tumor is a rare tumor type and has an unpredictable course. Local recurrence rate varies between 9 and 19%, and rate of metastatic involvement between 0 and 36 %. It is characterized by a typical architecture and immuno-histochemistry tests. The most important prognostic factor is the complete resection of primary tumor. Treatment of recurrences is not clearly established. If a solitary fibrous tumor is too advanced to allow surgical resection, radiotherapy and chemotherapy may be used. The most often used drugs are doxorubicine and\or ifosfamide. We report the case of man with metastatic solitary fibrous tumor treated with trabectedin, administered at a dose of 1.5 mg/m² every 3 weeks. After 3 cycles, metastases had significantly decreased. Recurrence of the disease was demonstrated 8 months after the start of trabectedin. This case shows that trabectedin is a possible treatment option.
authors: Department of Medical Oncology, Universitary Hospital Center J. Minjoz, Besançon, France;
authors: Loïc
authors: L
authors: Chaigneau
authors: Elsa
authors: E
authors: Kalbacher
authors: Antoine
authors: A
authors: Thiery-Vuillemin
authors: Christine
authors: C
authors: Fagnoni-Legat
authors: Nicolas
authors: N
authors: Isambert
authors: Lionel
authors: L
authors: Aherfi
authors: Julien
authors: J
authors: Pauchot
authors: Delphine
authors: D
authors: Delroeux
authors: Stephanie
authors: S
authors: Servagi-Vernat
authors: Laura
authors: L
authors: Mansi
authors: Xavier
authors: X
authors: Pivot