title: Six-year experience of permanent prostate brachytherapy for clinically localized prostate cancer.
abstract: This report presents the outcome of prostate permanent brachytherapy (PPB). One hundred and seventy-two patients with clinically localized prostate cancer were treated with permanent brachytherapy using iodine-125 seeds (125-I) at Hiroshima University Hospital from July 2004 to June 2010. This study evaluated the efficacy of PPB in these patients. The median patient age was 69 years (range 53 to 82 years), the median prostate-specific antigen (PSA) value before biopsy was 6.75 ng/ml (range 3.5 to 47.9 ng/ml), and the median prostate volume was 23.1 ml (range 10.1 to 57 ml). The median follow-up was 37 months (range 1 to 72 months). The serum PSA levels decreased continuously after PPB throughout the entire follow-up period in 97% of patients without neoadjuvant hormonal therapy. No relapse occurred during the follow-up period in patients at low risk. Our 6-year experience suggests that PPB is effective for localized prostate cancer. Patients with prostate cancer that does not require combined external beam radiation therapy (EBRT) have the best chance of responding to treatment.
authors: Department of Urology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
authors: Jun
authors: J
authors: Teishima
authors: Masahiro
authors: M
authors: Kenjo
authors: Kohei
authors: K
authors: Kobatake
authors: Hideo
authors: H
authors: Iwamoto
authors: Akihiro
authors: A
authors: Goriki
authors: Mami
authors: M
authors: Oki
authors: Koichi
authors: K
authors: Shoji
authors: Katsutoshi
authors: K
authors: Miyamoto
authors: Hiroshi
authors: H
authors: Masumoto
authors: Shogo
authors: S
authors: Inoue
authors: Kanao
authors: K
authors: Kobayashi
authors: Shinya
authors: S
authors: Ohara
authors: Mitsuru
authors: M
authors: Kajiwara
authors: Tomoki
authors: T
authors: Kimura
authors: Yuji
authors: Y
authors: Murakami
authors: Yuko
authors: Y
authors: Kaneyasu
authors: Ikuno
authors: I
authors: Nishibuchi
authors: Yasushi
authors: Y
authors: Nagata
authors: Akio
authors: A
authors: Matsubara
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D001918:Brachytherapy; D018572:Disease-Free Survival; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D007564:Japan; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000276:immunology / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007457:Iodine Radioisotopes; D017430:Prostate-Specific Antigen