title: Significant association of SRC protein expression with the progression, recurrence, and prognosis of oral squamous cell carcinoma in Taiwan.
abstract: BACKGROUND
  Src protein overexpression correlates with progression and prognosis of a variety of human cancers.
  
  
  METHODS
  This study used immunohistochemistry to examine the expression of Src protein in 93 specimens of oral squamous cell carcinoma (OSCC).
  
  
  RESULTS
  We found a significant association of high expression of Src protein (labeling indices >50%) with larger tumor size (p = .017), positive lymph node metastasis (p = .030), more advanced clinical stages (p = .007), and recurrence (p < .001) of OSCC. High expression of Src protein was identified as an independent unfavorable prognosis factor by multivariate Cox regression analysis. The Kaplan-Meier curve showed that patients with OSCC with high expression of Src protein had a significantly poorer cumulative survival than those with low expression of Src protein (log-rank test, p = .00267).
  
  
  CONCLUSIONS
  The expression of Src protein is significantly associated with the progression, recurrence, and prognosis of OSCCs in Taiwan.
authors: Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.
authors: Shih-Jung
authors: SJ
authors: Cheng
authors: Sang-Heng
authors: SH
authors: Kok
authors: Jang-Jaer
authors: JJ
authors: Lee
authors: Mark
authors: M
authors: Yen-Ping Kuo
authors: Shih-Lung
authors: SL
authors: Cheng
authors: Ying-Luo
authors: YL
authors: Huang
authors: Hsin-Ming
authors: HM
authors: Chen
authors: Hao-Hueng
authors: HH
authors: Chang
authors: Chun-Pin
authors: CP
authors: Chiang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism*; D011379:Prognosis; D040901:Proteomics; D016392:Proto-Oncogene Proteins pp60(c-src) / Q000378:metabolism*; D012008:Recurrence; D013624:Taiwan
chemical_list: D014408:Biomarkers, Tumor; D016392:Proto-Oncogene Proteins pp60(c-src)