title: CRP and CD14 polymorphisms correlate with coronary plaque volume in patients with coronary artery disease--IVUS substudy of the ENCORE trials.
abstract: BACKGROUND
  Several proinflammatory single-nucleotide polymorphisms (SNPs) have been linked to the progression of atherosclerosis and coronary artery disease (CAD). Plaque size and its destabilization by inflammatory processes are major determinants of ischemia and acute coronary syndromes. Intravascular ultrasound (IVUS) allows for quantification of plaque size in vivo. We therefore investigated the relation of plaque size with mutations of proinflammatory genes in patients with CAD.
  
  
  METHODS
  In 196 patients with stable CAD enrolled in the ENCORE trials coronary plaque and vessel volume was assessed by IVUS. 173 patients were successfully genotyped for polymorphisms of proinflammatory genes CD14 C(-260)T and CRP C(+1444)T using the single-nucleotide polymorphism polymerase chain reaction (SNP PCR) approach.
  
  
  RESULTS
  Baseline characteristics were comparable for all genotype groups. Higher ratios of plaque volume/vessel volume were observed in patients with the CRP 1444TT (n=11) and CD14 260TT (n=33) genotypes (p=0.016 and p=0.026, respectively).
  
  
  CONCLUSIONS
  In patients with stable coronary artery disease the CRP 1444TT and CD14 260TT variants are associated with larger coronary plaque volume independently of concomitant cardiovascular risk factors.
authors: Department of Cardiology, Cardiovascular Center, University Hospital, CH-8091 Zürich, Switzerland.
authors: Matthias
authors: M
authors: Hermann
authors: Dieter
authors: D
authors: Fischer
authors: Michael M
authors: MM
authors: Hoffmann
authors: Theo
authors: T
authors: Gasser
authors: Kurt
authors: K
authors: Quitzau
authors: Thomas
authors: T
authors: Meinertz
authors: Thomas
authors: T
authors: Münzel
authors: Thomas F
authors: TF
authors: Lüscher
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000235:genetics*; D016009:Chi-Square Distribution; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000235:genetics* / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D018836:Inflammation Mediators; D018950:Lipopolysaccharide Receptors / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging / Q000235:genetics* / Q000276:immunology; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D016032:Randomized Controlled Trials as Topic; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D018084:Ultrasonography, Interventional
chemical_list: D018836:Inflammation Mediators; D018950:Lipopolysaccharide Receptors; D002097:C-Reactive Protein