title: Effects of pioglitazone versus simvastatin on biomarkers of inflammation in patients on high cardiovascular risk.
abstract: High levels of fetuin-A has been linked to cardiovascular disease, possibly via modulating low-grade systemic inflammation. We performed a subanalysis from the PIOSTAT study to investigate a possible link between fetuin-A and the inflammatory biomarker hs-CRP. 66 nondiabetic individuals at cardiovascular risk were randomized to either pioglitazone, simvastatin, or the combination of both, and followed for 12 weeks. At study endpoint, correlations between serum fetuin-A, hs-CRP, blood lipids, PAI-1, MMP-9, HOMA-IR, and liver transaminases were investigated by Spearman rank correlation. Changes in fetuin-A concentration did not correlate to changes in hs-CRP (r=0.19, p=0.16). A positive correlation was found for change of HOMA-IR value (r=0.33, p=0.01) and for the AST/ALT ratio (p<0.05). Our data suggest that the previously observed correlation between elevated circulating fetuin-A and hs-CRP in epidemiological studies may not reflect a causal relationship in nondiabetic patients on high cardiovascular risk.
authors: Center for Clinical Studies – Metabolism and Endocrinology , Science and Technology Transfer, TU Dresden, Germany. hanefeld@gwtonline-zks.de
authors: M
authors: M
authors: Hanefeld
authors: F
authors: F
authors: Schaper
authors: D
authors: D
authors: Appelt
authors: W
authors: W
authors: Fuchs
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000276:immunology; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000453:epidemiology / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077205:Pioglitazone; D011446:Prospective Studies; D012307:Risk Factors; D019821:Simvastatin / Q000627:therapeutic use*; D045162:Thiazolidinediones / Q000627:therapeutic use*; D060749:alpha-2-HS-Glycoprotein / Q000276:immunology
chemical_list: D015415:Biomarkers; D045162:Thiazolidinediones; D060749:alpha-2-HS-Glycoprotein; D002097:C-Reactive Protein; D019821:Simvastatin; D000077205:Pioglitazone