title: Liposomal formulation of curcumin attenuates seizures in different experimental models of epilepsy in mice.
abstract: Contemporary research indicates promising anticonvulsant effect of curcumin. However, its poor oral bioavailability is a major hindrance toward its pharmacological action. Thus, this study was carried out to evaluate the acute effect of liposome-entrapped curcumin on increasing current electroshock seizures (ICES) test, pentylenetetrazole (PTZ)-induced seizures, and status epilepticus in mice. Liposome-entrapped curcumin in doses 25 and 50 mg/kg demonstrated significant increase in seizure threshold current and latency to myoclonic and generalized seizures in ICES test and PTZ-induced seizures, respectively. Similarly, liposomal-entrapped curcumin also increased the latency to the onset and decreased the duration of seizures during status epilepticus in mice. To conclude, liposomal-entrapped curcumin possesses anticonvulsant activity against status epilepticus in mice.
authors: Department of Clinical Research, Faculty of Allied Health Sciences, Jamia Hamdard (Hamdard University), New Delhi-110062, India.
authors: Nidhi Bharal
authors: NB
authors: Agarwal
authors: Seema
authors: S
authors: Jain
authors: Dheeraj
authors: D
authors: Nagpal
authors: Nitin Kumar
authors: NK
authors: Agarwal
authors: Pramod K
authors: PK
authors: Mediratta
authors: Krishna K
authors: KK
authors: Sharma
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000737:chemistry; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003474:Curcumin / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D004195:Disease Models, Animal; D004347:Drug Interactions; D004827:Epilepsy / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D008081:Liposomes / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D000927:Anticonvulsants; D008081:Liposomes; D003474:Curcumin; D010433:Pentylenetetrazole