title: [The effect of the composition of stomatological dressings on Carbopol 971P and methylocelullose base on pharmaceutical availability of metronidazole].
abstract: The carried out studies allowed to propose composition of stomatological dressing makes opportunity to ensure preferable physiochemicals features for dosage forms. According to results formulations contain 1.5% Carbopol 971P, 0.13% methylocelullose and various quantity of glycerol, 1,2-propylene glycol and polyethylene glycol 400 were prepared. To compare formulation consists of only polymers dispersion (Carbopol 971P and methylocelullose) was prepared. Next to produced compound triethanoloamine to pH range 5.5-6.5 and 1% metronidazole added. Kinetics test of metronidazole release was performed in vitro using Hanson's cells and semipermable membrane. The quantity of the release metronidazole was determined by spectrophotometric method. Gel consists of 98% polymers dyspersion with 2% glycerol characterized by the largest pharmaceutical availability. The addition of 2% PEG 400 resulted in the decrease of the percentage of released substance in comparison to formulation without hydrophylisers. Metronidazole releasing was more efficient for dressings with 2% glycerol as well propylene glycol. For preparations contains glycerol (2 and 5%) as well propylene glycol as adiuvants, it was found that gels prepared on Carbopol 971P and methylocelullose revealed higher pharmaceutical availability than analogical dressings prepared with only one polymer base.
authors: Katedra i Zakład Technologii Postaci Leku Akademia Medyczna we Wrocławiu. dorkid@wp.pl
authors: Dorota
authors: D
authors: Kida
authors: Janusz
authors: J
authors: Pluta
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D001458:Bandages; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D005990:Glycerol / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008747:Methylcellulose / Q000737:chemistry*; D008795:Metronidazole / Q000032:analysis* / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D019946:Propylene Glycol / Q000737:chemistry; D054047:Surgical Stomas
chemical_list: D000179:Acrylates; C492577:carbopol 971P; D008795:Metronidazole; D011092:Polyethylene Glycols; D019946:Propylene Glycol; D008747:Methylcellulose; D005990:Glycerol