title: Inclusion complexes of phosphorylated daidzein derivatives with β-cyclodextrin: Preparation and inclusion behavior study.
abstract: In the present work the feasibility of β-cyclodextrin in complexation was explored, as a tool for improving the solubility and biological ability of daidzein derivatives. A series of phosphorylated daidzein derivatives featuring different chain lengths were synthesized through a modified Atherton-Todd reaction and their inclusion complexes with βCD were prepared by coprecipitation method. The inclusion complexation behavior was studied by fluorescence, UV, FT-IR, MS and (1)H NMR. The results showed that only phosphorylated daidzein derivative carrying small substituent group ((C(2)H(5)O)(2)PO) entered the cavity of βCD and formed 1:1 inclusion complex. The formation constant was 175(mol/L)(-1).
authors: College of Chemistry & Chemical Engineering, Henan University of Technology, Zhengzhou 450001, People's Republic of China. henangongda@yahoo.com
authors: Yongmei
authors: Y
authors: Xiao
authors: Liangru
authors: L
authors: Yang
authors: Pu
authors: P
authors: Mao
authors: Jinwei
authors: J
authors: Yuan
authors: Yuxia
authors: Y
authors: Deng
authors: Lingbo
authors: L
authors: Qu
mesh_terms: D007529:Isoflavones / Q000138:chemical synthesis / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010766:Phosphorylation; D048789:Phytoestrogens / Q000138:chemical synthesis / Q000737:chemistry*; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D007529:Isoflavones; D048789:Phytoestrogens; D047392:beta-Cyclodextrins; C004742:daidzein; C031215:betadex