title: Towards new uses of botulinum toxin as a novel therapeutic tool.
abstract: The uses of botulinum toxin in the fields of neurology, ophthalmology, urology, rehabilitation medicine and aesthetic applications have been revolutionary for the treatment of patients. This non-invasive therapeutic has continually been developed since first discovered in the 1970s as a new approach to what were previously surgical treatments. As these applications develop, so also the molecules are developing into tools with new therapeutic properties in specific clinical areas. This review examines how the botulinum toxin molecule is being adapted to new therapeutic uses and also how new areas of use for the existing molecules are being identified. Prospects for future developments are also considered.
authors: Biologicals Science and Technology, Ipsen Biopharm Limited, Ash Road North, Wrexham, LL13 9UF, UK. andy.pickett@ipsen.com
authors: Andy
authors: A
authors: Pickett
authors: Karen
authors: K
authors: Perrow
mesh_terms: D000818:Animals; D001665:Binding Sites; D001905:Botulinum Toxins / Q000737:chemistry / Q000235:genetics / Q000494:pharmacology / Q000627:therapeutic use*; D055808:Drug Discovery / Q000379:methods / Q000639:trends; D006801:Humans; D011485:Protein Binding; D011487:Protein Conformation; D015202:Protein Engineering; D020033:Protein Isoforms; D013329:Structure-Activity Relationship
chemical_list: D020033:Protein Isoforms; D001905:Botulinum Toxins