title: The feasibility of endocardial propagation mapping using magnetic resonance guidance in a Swine model, and comparison with standard electroanatomic mapping.
abstract: The introduction of electroanatomic mapping (EAM) has improved the understanding of the substrate of ventricular tachycardia. EAM systems are used to delineate scar regions responsible for the arrhythmia by creating voltage or activation time maps. Previous studies have identified the benefits of creating MR-guided voltage maps; however, in some cases voltage maps may not identify regions of slow propagation that can cause the reentrant tachycardia. In this study, we obtained local activation time maps and analyzed propagation properties by performing MR-guided mapping of the porcine left ventricle while pacing from the right ventricle. Anatomical and myocardial late gadolinium enhancement images were used for catheter navigation and identification of scar regions. Our MR-guided mapping procedure showed qualitative correspondence to conventional clinical EAM systems in healthy pigs and demonstrated altered propagation in endocardial infarct models.
authors: Imaging Research, Sunnybrook Research Institute, Toronto, ON, Canada. soduneye@sri.utoronto.ca
authors: Samuel O
authors: SO
authors: Oduneye
authors: Labonny
authors: L
authors: Biswas
authors: Sudip
authors: S
authors: Ghate
authors: Venkat
authors: V
authors: Ramanan
authors: Jennifer
authors: J
authors: Barry
authors: Avishag
authors: A
authors: Laish-FarKash
authors: Ehud
authors: E
authors: Kadmon
authors: Tawfiq
authors: T
authors: Zeidan Shwiri
authors: Eugene
authors: E
authors: Crystal
authors: Graham A
authors: GA
authors: Wright
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D022062:Electrophysiologic Techniques, Cardiac / Q000379:methods*; D005240:Feasibility Studies; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D023421:Models, Animal; D009203:Myocardial Infarction / Q000503:physiopathology; D015203:Reproducibility of Results; D013552:Swine; D016276:Ventricular Function / Q000502:physiology*