title: Short-term effects of vitamin D receptor activation on serum creatinine, creatinine generation, and glomerular filtration.
abstract: Vitamin D receptor activation may have pleiotropic effects in a variety of tissues. Experimental studies with vitamin D receptor activation demonstrate an ability to delay progression of renal disease. In humans, vitamin D receptor activation reduces albuminuria. Yet some clinical studies demonstrate that patients receiving vitamin D supplementation have an elevation in serum creatinine and a decline in estimated glomerular filtration rate. These observations may be explainable by an effect of vitamin D receptor activation on creatinine metabolism.
authors: Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. mweir@medicine.umaryland.edu
authors: Matthew R
authors: MR
authors: Weir
mesh_terms: D003404:Creatinine / Q000097:blood*; D004872:Ergocalciferols / Q000008:administration & dosage*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D007674:Kidney Diseases / Q000188:drug therapy*; D008297:Male; D018167:Receptors, Calcitriol / Q000819:agonists*
chemical_list: D004872:Ergocalciferols; D018167:Receptors, Calcitriol; C084656:paricalcitol; D003404:Creatinine