title: New-generation vaccines against cholera.
abstract: Cholera is a major global health problem, causing approximately 100,000 deaths annually, about half of which occur in sub-Saharan Africa. Although early-generation parenteral cholera vaccines were abandoned as public health tools owing to their limited efficacy, newer-generation oral cholera vaccines have attractive safety and protection profiles. Both killed and live oral vaccines have been licensed, although only killed oral vaccines are currently manufactured and available. These killed oral vaccines not only provide direct protection to vaccinated individuals, but also confer herd immunity. The combination of direct vaccine protection and vaccine herd immunity effects makes these vaccines highly cost-effective and, therefore, attractive for use in developing countries. Administration of these oral vaccines does not require qualified medical personnel, which makes their use practical--even in developing countries. Although new-generation oral cholera vaccines should not be considered in isolation from other preventive approaches, especially improved water quality and sanitation, they represent important tools in the public health armamentarium to control both endemic and epidemic cholera.
authors: International Vaccine Institute, Seoul National University Research Park, San 4-8, Nakseongdae-dong, Kwanak-gu, Seoul 151-919, Korea. jclemens@ivi.int
authors: John
authors: J
authors: Clemens
authors: Sunheang
authors: S
authors: Shin
authors: Dipika
authors: D
authors: Sur
authors: G Balakrish
authors: GB
authors: Nair
authors: Jan
authors: J
authors: Holmgren
mesh_terms: D002771:Cholera / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control; D022121:Cholera Vaccines / Q000494:pharmacology*; D004196:Disease Outbreaks / Q000517:prevention & control*; D014943:Global Health; D006801:Humans; D011634:Public Health; D014611:Vaccination; D014734:Vibrio cholerae / Q000276:immunology*
chemical_list: D022121:Cholera Vaccines