title: The fallacy of reduction.
abstract: The "accelerator hypothesis" has made a significant impact on research into the etiology of type 1 diabetes. Some, but not all prospective studies have confirmed a weak association between insulin resistance and faster progression to diabetes among persons with advanced islet autoimmunity. However, there is hardly any evidence that insulin resistance can cause development of islet autoimmunity, thus be responsible for the ongoing pandemic of type 1 diabetes in children.
authors: Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA. marian.rewers@ucdenver.edu
authors: Marian
authors: M
authors: Rewers
mesh_terms: D001323:Autoantibodies / Q000276:immunology; D015551:Autoimmunity / Q000276:immunology*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D018450:Disease Progression; D006801:Humans; D007333:Insulin Resistance / Q000276:immunology; D050417:Insulin-Secreting Cells / Q000473:pathology*; D007515:Islets of Langerhans / Q000276:immunology; D015430:Weight Gain / Q000502:physiology
chemical_list: D001323:Autoantibodies