title: Lack of association between  catalase gene polymorphism (T/C exon 9) and susceptibility to vitiligo in a  Turkish population.
abstract: Accumulation  of hydrogen peroxide (H(2)O(2)) and  low catalase (CAT) activity have been demonstrated in the epidermis of vitiligo  patients. We investigated a possible association between the CAT exon 9  (Asp-389) gene and vitiligo susceptibility in the Turkish population.  Thirty-four patients with vitiligo and 49 gender, age and ethnic matched  controls were enrolled in the study. Genotyping was done by PCR-RFLP. The CAT exon 9 (Asp-389) genotype and allele frequencies of vitiligo patients did  not differ significantly from those of healthy controls. We found no  association between CAT (Asp-389) gene polymorphism and vitiligo  susceptibility in Turkish vitiligo patients.
authors: Department of Biology, Faculty of Science, Ege University, Izmir, Turkey.
authors: H
authors: H
authors: Bulut
authors: M
authors: M
authors: Pehlivan
authors: S
authors: S
authors: Alper
authors: A G
authors: AG
authors: Tomatir
authors: H
authors: H
authors: Onay
authors: S E
authors: SE
authors: Yüksel
authors: F
authors: F
authors: Ozkinay
authors: S
authors: S
authors: Pehlivan
mesh_terms: D002374:Catalase / Q000235:genetics*; D005091:Exons; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D014421:Turkey / Q000208:ethnology; D014820:Vitiligo / Q000208:ethnology / Q000235:genetics*
chemical_list: D006861:Hydrogen Peroxide; D002374:Catalase