title: Cyclic di-GMP, an established secondary messenger still speeding up.
abstract: The secondary messenger cyclic di-GMP coordinately regulates the transition between motility/sessility/virulence in bacterial populations and upon adaptation to novel habitats. Thereby, multiple independent regulatory circuits regulate a diversity of targets. This specific output response is surprising considering the diverse physiological processes regulated by this signalling molecule, which range from transcription to proteolysis and clearly demonstrates the presence of sophisticated developmental programmes in these so-called simple organisms.
authors: Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. ute.romling@ki.se
authors: Ute
authors: U
authors: Römling
mesh_terms: D000818:Animals; D001419:Bacteria / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity; D018407:Bacterial Physiological Phenomena; D018441:Biofilms; D006152:Cyclic GMP / Q000031:analogs & derivatives* / Q000378:metabolism / Q000502:physiology; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D015290:Second Messenger Systems / Q000502:physiology*; D015398:Signal Transduction
chemical_list: C062025:bis(3',5')-cyclic diguanylic acid; D006152:Cyclic GMP