title: Chiral squaramide-catalyzed highly diastereo- and enantioselective direct Michael addition of nitroalkanes to nitroalkenes.
abstract: An efficient highly diastereo- and enantioselective direct Michael addition of nitroalkanes to nitroalkenes catalyzed by chiral squaramide catalyst has been developed. This organocatalytic reaction with a low catalyst loading (2 mol%) proceeded well to afford synthetically useful 1,3-dinitro compounds in high yields with high diastereoselectivities (up to 95 : 5 dr) and excellent enantioselectivities (up to 97% ee).
authors: School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing 100081, People's Republic of China.
authors: Wen
authors: W
authors: Yang
authors: Da-Ming
authors: DM
authors: Du