title: Obstetric and perinatal outcomes in women with eating disorders.
abstract: BACKGROUND
  We wished to investigate whether women with a history of eating disorders have an increased risk for adverse obstetric and perinatal outcomes.
  
  
  METHODS
  A retrospective study was conducted comparing pregnancy complications in patients with and without eating disorders. Deliveries occurred during the years 1988-2009 in a tertiary medical center. Women lacking prenatal care and with multiple gestations were excluded from the study. Stratified analyses were performed using multivariable logistic regression models. Odds ratios (OR) and their 95% confidence interval (CI) were computed. A p value<0.05 was considered statistically significant.
  
  
  RESULTS
  During the study period, of 117,875 singleton deliveries, 122 (0.1%) occurred in patients with eating disorders. Eating disorders were significantly associated with fertility treatments (5.7% vs. 2.8%, p=0.047), intrauterine growth restriction (7.4% vs. 2.3%, p<0.001), term low birth weight (<2500 g) (7.4% vs. 2.8%, p=0.002), preterm delivery (15.6% vs. 7.5%, p=0.002), and cesarean delivery (25.4% vs. 15.0%, p=0.001). Using multivariable analyses, low birth weight (OR 2.5, 95% CI 1.3-5.0), preterm delivery (OR 2.2, 95% CI 1.4-3.6), and cesarean section (OR 1.9, 95% CI 1.3-2.9) were significantly associated with eating disorders.
  
  
  CONCLUSIONS
  Eating disorders are associated with increased risk of adverse pregnancy outcomes. Accordingly, careful surveillance is needed for early detection of possible complications.
authors: Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors: Yael
authors: Y
authors: Pasternak
authors: Adi Y
authors: AY
authors: Weintraub
authors: Ilana
authors: I
authors: Shoham-Vardi
authors: Ruslan
authors: R
authors: Sergienko
authors: Jonathan
authors: J
authors: Guez
authors: Arnon
authors: A
authors: Wiznitzer
authors: Hadar
authors: H
authors: Shalev
authors: Eyal
authors: E
authors: Sheiner
mesh_terms: D000328:Adult; D002585:Cesarean Section / Q000706:statistics & numerical data; D016001:Confidence Intervals; D001068:Feeding and Eating Disorders / Q000453:epidemiology* / Q000517:prevention & control; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology; D005322:Premature Rupture of Fetal Membranes / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007247:Infertility, Female / Q000453:epidemiology; D007557:Israel / Q000453:epidemiology; D008425:Maternal Behavior; D016017:Odds Ratio; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology* / Q000517:prevention & control; D011256:Pregnancy Outcome / Q000453:epidemiology*; D011295:Prenatal Care / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D012307:Risk Factors; D016387:Women's Health; D055815:Young Adult