title: Regulation of neural stem cell in the human SVZ by trophic and morphogenic factors.
abstract: The subventricular zone (SVZ), lining the lateral ventricular system, is the largest germinal region in mammals. In there, neural stem cells express markers related to astoglial lineage that give rise to new neurons and oligodendrocytesin vivo.In the adult human brain,in vitroevidence has also shown that astrocytic cells isolated from the SVZ can generate new neurons and oligodendrocytes. These proliferative cells are strongly controlled by a number of signals and molecules that modulate, activate or repress the cell division, renewal, proliferation and fate of neural stem cells. In this review, we summarize the cellular composition of the adult human SVZ (hSVZ) and discuss the increasing evidence showing that some trophic modulators strongly control the function of neural stem cells in the SVZ.
authors: Department of Neuroscience, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara.
authors: Lucia E
authors: LE
authors: Alvarez-Palazuelos
authors: Forensic medicine. Instituto Jalisciense de Ciencias Forenses, Guadalajara, Jalisco.
authors: Martha S
authors: MS
authors: Robles-Cervantes
authors: Department of Neurosurgery. Instituto Nacional de Neurología y Neurocirugia "Manuel Velasco Suárez" México, DF.
authors: Gabriel
authors: G
authors: Castillo-Velazquez
authors: Forensic medicine. Instituto Jalisciense de Ciencias Forenses, Guadalajara, Jalisco.
authors: Mario
authors: M
authors: Rivas-Souza
authors: Department of Neuroscience, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara.
authors: Jorge
authors: J
authors: Guzman-Muniz
authors: Department of Neuroscience, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara.
authors: Norma
authors: N
authors: Moy-Lopez
authors: Department of Neuroscience, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara.
authors: Rocio E
authors: RE
authors: Gonzalez-Castaneda
authors: Department of Neuroscience, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara.
authors: Sonia
authors: S
authors: Luquin
authors: Department of Neuroscience, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara ; Laboratory of Neuroscience, Facultad de Psicología, Universidad de Colima, Colima, Col, México.
authors: Oscar
authors: O
authors: Gonzalez-Perez