title: Cycling or not cycling: cell cycle regulatory molecules and adult neurogenesis.
abstract: The adult brain most probably reaches its highest degree of plasticity with the lifelong generation and integration of new neurons in the hippocampus and olfactory system. Neural precursor cells (NPCs) residing both in the subgranular zone of the dentate gyrus and in the subventricular zone of the lateral ventricles continuously generate neurons that populate the dentate gyrus and the olfactory bulb, respectively. The regulation of NPC proliferation in the adult brain has been widely investigated in the past few years. Yet, the intrinsic cell cycle machinery underlying NPC proliferation remains largely unexplored. In this review, we discuss the cell cycle components that are involved in the regulation of NPC proliferation in both neurogenic areas of the adult brain.
authors: GIGA- Neurosciences, University of Liège, Liège, Belgium.
authors: Pierre
authors: P
authors: Beukelaers
authors: Renaud
authors: R
authors: Vandenbosch
authors: Nicolas
authors: N
authors: Caron
authors: Laurent
authors: L
authors: Nguyen
authors: Gustave
authors: G
authors: Moonen
authors: Brigitte
authors: B
authors: Malgrange
mesh_terms: D000328:Adult; D000818:Animals; D001921:Brain / Q000166:cytology / Q000254:growth & development / Q000502:physiology; D002453:Cell Cycle / Q000502:physiology*; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors / Q000502:physiology; D016213:Cyclins / Q000502:physiology; D006801:Humans; D051379:Mice; D008959:Models, Neurological; D058953:Neural Stem Cells / Q000166:cytology / Q000502:physiology; D055495:Neurogenesis / Q000502:physiology*
chemical_list: D016213:Cyclins; D018844:Cyclin-Dependent Kinases