title: Management of pediatric eosinophilic esophagitis: an update.
abstract: Eosinophilic esophagitis is an important chronic esophageal disorder with gastroesophageal reflux disease (GERD)-like symptoms, prominent esophageal mucosal eosinophilia, strongly associated with allergic disorders and unresponsive to anti-GERD therapy. Treatment of eosinophilic esophagitis has been successful with the use of dietary restrictions and topical corticosteroids. A subset of patients benefits from concurrent anti-GERD therapy; those with demonstrable esophageal strictures report variable duration symptom relief after esophageal dilation. At the current time, anti-interleukin-5 monoclonal antibody agents are being investigated in multicenter trials, and it is hoped that future therapy may be targeted against mediators of esophageal remodeling and fibrosis in eosinophilic esophagitis.
authors: Division of Gastroenterology, Hepatology and Nutrition, Children's National Medical Center, Washington, DC 20010, USA.
authors: Seema
authors: S
authors: Khan
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000818:Animals; D019468:Disease Management; D057765:Eosinophilic Esophagitis / Q000453:epidemiology* / Q000209:etiology / Q000628:therapy*; D005512:Food Hypersensitivity / Q000150:complications / Q000453:epidemiology / Q000628:therapy; D005764:Gastroesophageal Reflux / Q000453:epidemiology* / Q000209:etiology / Q000628:therapy*; D006801:Humans
chemical_list: D000305:Adrenal Cortex Hormones