title: Avocado fruit (Persea americana Mill) exhibits chemo-protective potentiality against cyclophosphamide induced genotoxicity in human lymphocyte culture.
abstract: Diets rich in fruits and vegetables have been associated with reduced risks for many types of cancers. Avocado (Persea americana Mill.) is a widely consumed fruit containing many cancer preventing nutrients, vitamins and phytochemicals. Studies have shown that phytochemicals extracted from the avocado fruit selectively induce cell cycle arrest, inhibit growth, and induce apoptosis in precancerous and cancer cell lines. Our recent studies indicate that phytochemicals extracted with 50% Methanol from avocado fruits help in proliferation of human lymphocyte cells and decrease chromosomal aberrations induced by cyclophosphamide. Among three concentrations (100 mg, 150 mg and 200 mg per Kg Body Weight), the most effective conc. of extract was 200 mg/Kg Body Wt. It decreased significant level of numerical and structural aberrations (breaks, premature centromeric division etc. up to 88%, p < 0.0001)), and accrocentric associtation within D & G group (up to 78%, p = 0.0008). These studies suggest that phytochemicals from the avocado fruit can be utilized for making active chemoprotective ingredient for lowering the side effect of chemotherapy like cyclophosphamide in cancer therapy.
authors: Department of Research, Jawaharlal Nehru Cancer Hospital and Research Centre, Idgah Hills, Bhopal, India. rajkumarpaul81@gmail.com
authors: Rajkumar
authors: R
authors: Paul
authors: Paresh
authors: P
authors: Kulkarni
authors: Narayan
authors: N
authors: Ganesh
mesh_terms: D002478:Cells, Cultured; D002503:Centromere / Q000187:drug effects / Q000235:genetics; D018890:Chemoprevention; D002869:Chromosome Aberrations / Q000139:chemically induced / Q000187:drug effects*; D003520:Cyclophosphamide / Q000633:toxicity; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D008214:Lymphocytes; D008677:Metaphase / Q000235:genetics; D027421:Persea / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D010936:Plant Extracts; D003520:Cyclophosphamide