title: Cholinergic modulation of a specific memory function of prefrontal cortex.
abstract: Deficits in prefrontal cholinergic function are implicated in cognitive impairment in many neuropsychiatric diseases, but acetylcholine's specific role remains elusive. Rhesus monkeys with selective lesions of cholinergic input to prefrontal cortex (PFC) were unimpaired in tests of decision making and episodic memory that require intact PFC, but were severely impaired on a spatial working memory task. These observations are consistent with a specific role for prefrontal acetylcholine in working memory.
authors: Glickenhaus Laboratory of Neuropsychology and Friedman Brain Institute, Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA.
authors: Paula L
authors: PL
authors: Croxson
authors: Diana A
authors: DA
authors: Kyriazis
authors: Mark G
authors: MG
authors: Baxter
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000110:Acetylcholinesterase / Q000378:metabolism; D000704:Analysis of Variance; D000818:Animals; D000911:Antibodies, Monoclonal / Q000633:toxicity; D003216:Conditioning, Operant / Q000187:drug effects / Q000502:physiology; D003657:Decision Making / Q000502:physiology*; D000922:Immunotoxins / Q000633:toxicity; D008253:Macaca mulatta; D008570:Memory, Short-Term / Q000502:physiology*; D010320:Parvalbumins / Q000378:metabolism; D010775:Photic Stimulation / Q000379:methods; D017397:Prefrontal Cortex / Q000187:drug effects / Q000293:injuries / Q000502:physiology*; D011897:Random Allocation; D012201:Reward; D054789:Ribosome Inactivating Proteins, Type 1 / Q000633:toxicity; D000076985:Saporins; D013028:Space Perception; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; D000922:Immunotoxins; C108575:ME20.4 IgG-saporin; D010320:Parvalbumins; D054789:Ribosome Inactivating Proteins, Type 1; D014446:Tyrosine 3-Monooxygenase; D000110:Acetylcholinesterase; D000076985:Saporins; D000109:Acetylcholine