title: Catalytic asymmetric construction of spirocyclopentaneoxindoles by a combined Ru-catalyzed cross-metathesis/double Michael addition sequence.
abstract: Biologically important and synthetically challenging spirocyclopentaneoxindoles with four contiguous stereocenters including one spiroquaternary stereocenter have been constructed in good yields (72-87%) with excellent diastereoselectivity (16:1→30:1 dr) and enantioselectivity (93→99% ee) by a combined Ru-catalyzed cross-metathesis/organocatalyzed asymmetric double-Michael addition sequence.
authors: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
authors: Ying-Mei
authors: YM
authors: Li
authors: Xiang
authors: X
authors: Li
authors: Fang-Zhi
authors: FZ
authors: Peng
authors: Ze-Qian
authors: ZQ
authors: Li
authors: Shou-Tao
authors: ST
authors: Wu
authors: Zhong-Wen
authors: ZW
authors: Sun
authors: Hong-Bin
authors: HB
authors: Zhang
authors: Zhi-Hui
authors: ZH
authors: Shao
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D000078183:Oxindoles; D012428:Ruthenium / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D003517:Cyclopentanes; D007211:Indoles; D000078183:Oxindoles; D013141:Spiro Compounds; C022960:2-oxindole; D012428:Ruthenium