title: Defining treatment response in pediatric tic disorders: a signal detection analysis of the Yale Global Tic Severity Scale.
abstract: OBJECTIVE
  To examine the optimal Yale Global Tic Severity Scale (YGTSS) percent reduction and raw cutoffs for predicting treatment response among children and adolescents with tic disorders.
  
  
  METHODS
  Youth with a tic disorder (N=108; range=5-17 years) participated in several clinical trials involving varied medications or psychosocial treatment, or received naturalistic care. Assessments were conducted before and after treatment and included the YGTSS and response status on the Clinical Global Impressions-Improvement Scale (CGI-I).
  
  
  RESULTS
  A 35% reduction on the YGTSS total tic severity score or a YGTSS raw total tic severity score change of 6 or 7 points were the best indicators of clinical treatment response in youth with tic disorders.
  
  
  CONCLUSIONS
  A YGTSS total tic severity score reduction of 35% or a raw total tic severity score change of 6 or 7 appears optimal for determining treatment response. A consistent definition of treatment response on the YGTSS may facilitate cross-study comparability. Practitioners can use these values for treatment planning decisions (e.g., change medications, etc.).
authors: Department of Pediatrics, University of South Florida, Tampa, FL, USA. estorch@health.usf.edu
authors: Eric A
authors: EA
authors: Storch
authors: Alessandro S
authors: AS
authors: De Nadai
authors: Adam B
authors: AB
authors: Lewin
authors: Joseph F
authors: JF
authors: McGuire
authors: Anna M
authors: AM
authors: Jones
authors: P Jane
authors: PJ
authors: Mutch
authors: R Doug
authors: RD
authors: Shytle
authors: Tanya K
authors: TK
authors: Murphy
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic / Q000523:psychology / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008297:Male; D017063:Outcome Assessment, Health Care / Q000379:methods / Q000706:statistics & numerical data*; D011237:Predictive Value of Tests; D012720:Severity of Illness Index; D017603:Signal Detection, Psychological; D013981:Tic Disorders / Q000175:diagnosis*