title: Association of cord blood magnesium concentration and neonatal resuscitation.
abstract: OBJECTIVE
  To assess the relationship between umbilical cord blood magnesium concentration and level of delivery room resuscitation received by neonates.
  
  
  METHODS
  This was a secondary analysis of a controlled fetal neuroprotection trial that enrolled women at imminent risk for delivery between 24 and 31 weeks' gestation and randomly allocated them to receive either intravenous magnesium sulfate or placebo. The cohort included 1507 infants with data available on total cord blood Mg concentration and delivery room resuscitation. Multivariate logistic regression was used to estimate the association between cord blood Mg concentration and highest level of delivery room resuscitation, using the following hierarchy: none, oxygen only, bag-mask ventilation with oxygen, intubation, and chest compressions.
  
  
  RESULTS
  There was no relationship between cord blood Mg and delivery room resuscitation (OR, 0.92 for each 1.0-mEq/L increase in Mg; 95% CI, 0.83-1.03). Maternal general anesthesia was associated with increased neonatal resuscitation (OR, 2.51; 95% CI, 1.72-3.68). Each 1-week increase in gestational age at birth was associated with decreased neonatal resuscitation (OR, 0.63; 95% CI, 0.60-0.66).
  
  
  CONCLUSIONS
  Cord blood Mg concentration does not correlate with the level of delivery room resuscitation of infants exposed to magnesium sulfate for fetal neuroprotection.
authors: Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. lynn.johnson@me.com
authors: Lynn H
authors: LH
authors: Johnson
authors: Delicia C
authors: DC
authors: Mapp
authors: Dwight J
authors: DJ
authors: Rouse
authors: Catherine Y
authors: CY
authors: Spong
authors: Brian M
authors: BM
authors: Mercer
authors: Kenneth J
authors: KJ
authors: Leveno
authors: Michael W
authors: MW
authors: Varner
authors: Jay D
authors: JD
authors: Iams
authors: Yoram
authors: Y
authors: Sorokin
authors: Susan M
authors: SM
authors: Ramin
authors: Menachem
authors: M
authors: Miodovnik
authors: Mary J
authors: MJ
authors: O'Sullivan
authors: Alan M
authors: AM
authors: Peaceman
authors: Steve N
authors: SN
authors: Caritis
mesh_terms: D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D008278:Magnesium Sulfate / Q000097:blood*; D008297:Male; D011446:Prospective Studies; D012151:Resuscitation / Q000706:statistics & numerical data*
chemical_list: D008278:Magnesium Sulfate