title: [Frontiers in vitamin D; basic research and clinical application. Is VDR a factor of bone volume regulator in bone tissues?].
abstract: Vitamin D is one of the best established hormone to exert beneficial action for bone mass control and bone metabolism. Such vitamin D action for bone tissue is recapitulated in intact animals, while vitamin D is well known to potentiate bone resorption by inducing gene of RANKL an osteoclastic inducer. By genetic characterization of VDR in mice, VDR was found to serve as a negative regulator in intact bone. Moreover, RANKL gene expression level in intact bone was down-regulated in osteoblast-specific VDR KO mice. Thus, these findings indicate that VDR in bone tissue is a negative regulator for bone mass control.
authors: IMCB, The University of Tokyo, Japan.
authors: Shigeaki
authors: S
authors: Kato
authors: Yoko
authors: Y
authors: Yamamoto
mesh_terms: D000818:Animals; D015519:Bone Density / Q000235:genetics / Q000502:physiology*; D016723:Bone Remodeling / Q000235:genetics / Q000502:physiology; D001862:Bone Resorption; D001842:Bone and Bones / Q000378:metabolism*; D015536:Down-Regulation; D017353:Gene Deletion; D015870:Gene Expression; D006801:Humans; D051379:Mice; D010006:Osteoblasts / Q000378:metabolism; D053245:RANK Ligand / Q000378:metabolism; D018167:Receptors, Calcitriol / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D014807:Vitamin D / Q000502:physiology
chemical_list: D053245:RANK Ligand; D018167:Receptors, Calcitriol; D014807:Vitamin D