title: β-PNA: peptide nucleic acid (PNA) with a chiral center at the β-position of the PNA backbone.
abstract: Peptide nucleic acid (PNA) monomers with a methyl group at the β-position have been synthesized. The modified monomers were incorporated into PNA oligomers using Fmoc chemistry for solid-phase synthesis. Thermal denaturation and circular dichroism (CD) studies have shown that PNA containing the S-form monomers was well suited to form a hybrid duplex with DNA, whose stability was comparable to that of unmodified PNA-DNA duplex, whereas PNA containing the R-form monomers was not.
authors: Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba, Tokyo 153-8902, Japan. csugi@mail.ecc.u-tokyo.ac.jp
authors: Toru
authors: T
authors: Sugiyama
authors: Yasutada
authors: Y
authors: Imamura
authors: Yosuke
authors: Y
authors: Demizu
authors: Masaaki
authors: M
authors: Kurihara
authors: Masashi
authors: M
authors: Takano
authors: Atsushi
authors: A
authors: Kittaka
mesh_terms: D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D060327:Solid-Phase Synthesis Techniques; D013237:Stereoisomerism
chemical_list: D020135:Peptide Nucleic Acids; D004247:DNA