title: Novel treatment options of binge eating disorder.
abstract: Obesity is a major problem of modern societies that sometimes, but not necessarily, is associated with binge-eating disorder (BED), a relatively new disorder characterized by binge eating without purging. The purpose of this article is to review the rationale for the potential use of pharmacological treatments in BED, and the potential use of the recently proposed compounds. Therefore, a careful medline of published articles from 1980 to December 2010 was carried out using the following keywords: BED and treatment, topiramate, zonisamide, sibutramine, venlafaxine, duloxetine, ghrelin, opiate blockers. Single case reports, observational studies, opinion articles, and studies concerning adults with syndromes resulting in BED (i.e., night eating syndrome) were also reviewed. All examined papers would indicate that the pharmacological treatment of BED is still heterogenous and poorly established, mainly for the lack of controlled studies in large samples of patients. In any case, the data on serotonin and norepinephrine reuptake inhibitors and on novel anticonvulsants seem quite promising in terms of efficacy and tolerability. In addition, the preliminary findings on the possibility of modulating appetite through the interference with the ghrelin system suggest new and intriguing ways of intervention in BED.
authors: Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, via Roma, 67, I-56100 Pisa, Italy. dmarazzi@psico.med.unipi.it
authors: D
authors: D
authors: Marazziti
authors: L
authors: L
authors: Rossi
authors: S
authors: S
authors: Baroni
authors: G
authors: G
authors: Consoli
authors: E
authors: E
authors: Hollander
authors: M
authors: M
authors: Catena-Dell'Osso
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D056912:Binge-Eating Disorder / Q000188:drug therapy*; D005632:Fructose / Q000031:analogs & derivatives / Q000627:therapeutic use; D054439:Ghrelin / Q000819:agonists / Q000378:metabolism; D006801:Humans; D007555:Isoxazoles / Q000627:therapeutic use; D009292:Narcotic Antagonists; D011957:Receptors, Opioid / Q000378:metabolism; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D000077236:Topiramate; D000078305:Zonisamide
chemical_list: D000927:Anticonvulsants; D005632:Fructose; D054439:Ghrelin; D007555:Isoxazoles; D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D017367:Selective Serotonin Reuptake Inhibitors; D000077236:Topiramate; D000078305:Zonisamide