title: Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo.
abstract: Advancing understanding of human coronary artery disease requires new methods that can be used in patients for studying atherosclerotic plaque microstructure in relation to the molecular mechanisms that underlie its initiation, progression and clinical complications, including myocardial infarction and sudden cardiac death. Here we report a dual-modality intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo using a combination of optical frequency domain imaging (OFDI) and near-infrared fluorescence (NIRF) imaging. By providing simultaneous molecular information in the context of the surrounding tissue microstructure, this new catheter could provide new opportunities for investigating coronary atherosclerosis and stent healing and for identifying high-risk biological and structural coronary arterial plaques in vivo.
authors: Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA.
authors: Hongki
authors: H
authors: Yoo
authors: Jin Won
authors: JW
authors: Kim
authors: Milen
authors: M
authors: Shishkov
authors: Eman
authors: E
authors: Namati
authors: Theodore
authors: T
authors: Morse
authors: Roman
authors: R
authors: Shubochkin
authors: Jason R
authors: JR
authors: McCarthy
authors: Vasilis
authors: V
authors: Ntziachristos
authors: Brett E
authors: BE
authors: Bouma
authors: Farouc A
authors: FA
authors: Jaffer
authors: Guillermo J
authors: GJ
authors: Tearney
mesh_terms: D000818:Animals; D001158:Arteries / Q000737:chemistry*; D057785:Catheters; D003324:Coronary Artery Disease / Q000175:diagnosis; D006801:Humans; D007249:Inflammation / Q000175:diagnosis; D057054:Molecular Imaging / Q000379:methods*; D009203:Myocardial Infarction / Q000150:complications / Q000473:pathology; D058226:Plaque, Atherosclerotic / Q000150:complications / Q000378:metabolism / Q000473:pathology; D011817:Rabbits; D019265:Spectroscopy, Near-Infrared / Q000379:methods*