title: Synaptic protein expression is regulated by a pro-oxidant diet in APPxPS1 mice.
abstract: Dietary factors may play a role in Alzheimer's disease (AD) pathogenesis. In an effort to recapitulate some of the synaptic protein changes observed in the disease, AD transgenic and wild-type mice were fed either a normal or pro-oxidant diet for 3 months from three months of age. Pro-oxidant diet treatment resulted in altered expression of vesicular glutamate transporter-1 and glutamine synthetase, suggesting changes in glutamatergic synaptic function, and increased expression of urokinase plasminogen activator receptor, possibly reflecting oxidative stress.
authors: King's College London, Wolfson Centre for Age-Related Diseases, London, SE1 1UL, UK.
authors: Martin
authors: M
authors: Broadstock
authors: Rikke
authors: R
authors: Lewinsky
authors: Emma L
authors: EL
authors: Jones
authors: Cathy
authors: C
authors: Mitchelmore
authors: David R
authors: DR
authors: Howlett
authors: Paul T
authors: PT
authors: Francis
mesh_terms: D000544:Alzheimer Disease / Q000178:diet therapy* / Q000235:genetics / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000818:Animals; D019587:Dietary Supplements; D004195:Disease Models, Animal; D005786:Gene Expression Regulation / Q000187:drug effects* / Q000235:genetics; D005974:Glutamate-Ammonia Ligase / Q000378:metabolism; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation / Q000235:genetics; D016877:Oxidants / Q000008:administration & dosage*; D053764:Presenilin-1 / Q000235:genetics; D055293:Receptors, Urokinase Plasminogen Activator / Q000378:metabolism; D016708:Synaptophysin / Q000378:metabolism; D050598:Vesicular Glutamate Transport Protein 1 / Q000378:metabolism*
chemical_list: D016564:Amyloid beta-Protein Precursor; D016877:Oxidants; C508853:PSEN1 protein, human; D053764:Presenilin-1; D055293:Receptors, Urokinase Plasminogen Activator; C493464:SLC17A7 protein, human; D016708:Synaptophysin; D050598:Vesicular Glutamate Transport Protein 1; D005974:Glutamate-Ammonia Ligase