title: One-pot near-ambient temperature syntheses of aryl(difluoroenol) derivatives from trifluoroethanol.
abstract: Difluoroalkenylzinc reagents prepared from 1-(2'-methoxy-ethoxymethoxy)-2,2,2-trifluoroethane and 1-(N,N-diethylcarbamoyloxy)-2,2,2-trifluoroethane at ice bath temperatures underwent Negishi coupling with a range of aryl halides in a convenient one pot procedure. While significant differences between the enol acetal and carbamate reagents were revealed, the Negishi protocol compared very favourably with alternative coupling procedures in terms of overall yields from trifluoroethanol.
authors: WestChem Department of Pure and Applied Chemistry, Thomas Graham Building, 295 Cathedral Street, Glasgow, UK G1 1XL.
authors: Sara H
authors: SH
authors: Kyne
authors: Jonathan M
authors: JM
authors: Percy
authors: Robert D C
authors: RD
authors: Pullin
authors: Joanna M
authors: JM
authors: Redmond
authors: Peter G
authors: PG
authors: Wilson
mesh_terms: D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013696:Temperature; D014270:Trifluoroethanol / Q000737:chemistry*
chemical_list: D006845:Hydrocarbons, Fluorinated; D009942:Organometallic Compounds; D014270:Trifluoroethanol