title: [Seizures in neurofibromatosis. What is the risk?].
abstract: BACKGROUND
  The prevalence and the type of seizures associated with neurofibromatosis 1 (NF1) and 2 (NF2) are not adequately characterized.
  
  
  BACKGROUND
  NF1 has a birth incidence of one in 2500, and NF2 one in 25000. Seizures are an occasional complication in NF1 patients and there is no data for NF2 patients. Central nervous system tumors are always suspected, since NF1 and NF2 are caused by mutations in tumor suppressor gene controlling cell proliferation and differentiation.
  
  
  CONCLUSIONS
  The aim of this article is to provide a synthetic overview about epilepsy associated with NF1 and NF2 based on published studies. In NF1, the type of seizures and their response to therapy are reported, the heterogeneity of etiology is also discussed. For NF2 patients, no specific data are available; the current knowledge comes from series of NF2 patients for which seizures has revealed the disease or from isolated case reports of tumors associated with seizures.
  
  
  CONCLUSIONS
  Cryptogenic epilepsy without anatomic defect is likely to be related to NF1, while seizures seem to be secondary to leptomeningeal tumors (meningioma, meningioangiomatosis) in NF2 patients.
authors: Service de neurologie, hôpital d'instruction des armées Desgenettes, 108, boulevard Pinel, 69275 Lyon, France; Réseau NF Rhône-Alpes-Auvergnes, centre Léon-Bérard, 28, rue Laennec, 69008 Lyon, France.
authors: A
authors: A
authors: Drouet
mesh_terms: D006801:Humans; D008577:Meningeal Neoplasms / Q000150:complications / Q000000981:diagnostic imaging; D017253:Neurofibromatoses / Q000150:complications* / Q000000981:diagnostic imaging; D009456:Neurofibromatosis 1 / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D016518:Neurofibromatosis 2 / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography; D012307:Risk Factors; D012640:Seizures / Q000175:diagnosis / Q000209:etiology*