title: The prognostic and predictive value of ERCC-1, p53, bcl-2 and bax in epithelial ovarian cancer.
abstract: OBJECTIVE
  To evaluate the expression of ERCC-1 in patients with epithelial ovarian cancer (EOC) and to correlate it with the expression of p53, bcl-2 and bax.
  
  
  METHODS
  Tumor samples from 60 patients with EOC were immunohistochemically investigated for the expression of ERCC1, p53, bcl-2 and bax.
  
  
  RESULTS
  ERCC-1 expression was significantly decreased in serous and endometrioid compared to clear cell carcinomas. P53 expression was significantly increased in serous compared to clear cell carcinomas. Bax expression was significantly increased in serous carcinomas as compared to MMTs. High disease stage was correlated with low ERCC-1 and high bcl-2 expression. ERCC-1 expression was associated with increased disease-free interval.
  
  
  CONCLUSIONS
  ERCC-1 status seems to be correlated with disease-free interval, stage and tumor histologic subtype in patients with EOC. Nevertheless, our results indicate that single-gene expressions may be unreliable and thus caution is needed when used as potential prognostic or predictive markers.
authors: First Department of Pathology, Medical School, University of Athens, Greece.
authors: K
authors: K
authors: Avraam
authors: K
authors: K
authors: Pavlakis
authors: C
authors: C
authors: Papadimitriou
authors: T
authors: T
authors: Vrekoussis
authors: T
authors: T
authors: Panoskaltsis
authors: I
authors: I
authors: Messini
authors: E
authors: E
authors: Patsouris
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000032:analysis; D018269:Carcinoma, Endometrioid / Q000378:metabolism; D000077216:Carcinoma, Ovarian Epithelial; D004268:DNA-Binding Proteins / Q000032:analysis*; D018572:Disease-Free Survival; D004720:Endonucleases / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000378:metabolism* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*; D051028:bcl-2-Associated X Protein / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D051028:bcl-2-Associated X Protein; C071447:ERCC1 protein, human; D004720:Endonucleases