title: PINA v2.0: mining interactome modules.
abstract: The Protein Interaction Network Analysis (PINA) platform is a comprehensive web resource, which includes a database of unified protein-protein interaction data integrated from six manually curated public databases, and a set of built-in tools for network construction, filtering, analysis and visualization. The second version of PINA enhances its utility for studies of protein interactions at a network level, by including multiple collections of interaction modules identified by different clustering approaches from the whole network of protein interactions ('interactome') for six model organisms. All identified modules are fully annotated by enriched Gene Ontology terms, KEGG pathways, Pfam domains and the chemical and genetic perturbations collection from MSigDB. Moreover, a new tool is provided for module enrichment analysis in addition to simple query function. The interactome data are also available on the web site for further bioinformatics analysis. PINA is freely accessible at http://cbg.garvan.unsw.edu.au/pina/.
authors: Cancer Research Program, Peter Wills Bioinformatics Centre, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia.
authors: Mark J
authors: MJ
authors: Cowley
authors: Mark
authors: M
authors: Pinese
authors: Karin S
authors: KS
authors: Kassahn
authors: Nic
authors: N
authors: Waddell
authors: John V
authors: JV
authors: Pearson
authors: Sean M
authors: SM
authors: Grimmond
authors: Andrew V
authors: AV
authors: Biankin
authors: Sampsa
authors: S
authors: Hautaniemi
authors: Jianmin
authors: J
authors: Wu
mesh_terms: D000465:Algorithms; D000818:Animals; D016000:Cluster Analysis; D003196:Computer Graphics; D057225:Data Mining; D030562:Databases, Protein; D006801:Humans; D051379:Mice; D058977:Molecular Sequence Annotation; D025941:Protein Interaction Mapping; D011506:Proteins / Q000737:chemistry / Q000235:genetics; D051381:Rats; D012984:Software
chemical_list: D011506:Proteins