title: Predictors for poststroke outcomes: the Tel Aviv Brain Acute Stroke Cohort (TABASCO) study protocol.
abstract: BACKGROUND
  Recent studies have demonstrated that even survivors of mild stroke experience residual damage, which persists and in fact increases in subsequent years. About 45% of stroke victims remain with different levels of disability. Identifying factors associated with poststroke cognitive and neurological decline could potentially yield more effective therapeutic opportunities.
  
  
  OBJECTIVE
  We hypothesize that data based on biochemical, neuroimaging, genetic and psychological measures can, in aggregate, serve as better predictors for subsequent disability, cognitive and neurological deterioration, and suggest possible interventions.
  
  
  METHODS
  The Tel-Aviv Brain Acute Stroke Cohort (TABASCO) study is an ongoing, prospective cohort study that will recruit approximately 1125 consecutive first-ever mild-moderate stroke patients. It is designed to evaluate the association between predefined demographic, psychological, inflammatory, biochemical, neuroimaging and genetic markers, measured during the acute phase, and long-term outcome: subsequent cognitive deterioration, vascular events (including recurrent strokes), falls, affect changes, functional everyday difficulties and mortality.
  
  
  CONCLUSIONS
  This study is an attempt to comprehensively investigate the long-term outcome of mild-moderate strokes. Its prospective design will provide quantitative data on stroke recurrence, the incidence of other vascular events and the evaluation of cognitive, affective and functional decline. Identifying the factors associated with poststroke cognitive and functional decline could potentially yield more effective therapeutic approaches.
authors: Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel.
authors: Einor
authors: E
authors: Ben Assayag
authors: Amos D
authors: AD
authors: Korczyn
authors: Nir
authors: N
authors: Giladi
authors: Uri
authors: U
authors: Goldbourt
authors: A Sholmo
authors: AS
authors: Berliner
authors: Shani
authors: S
authors: Shenhar-Tsarfaty
authors: Efrat
authors: E
authors: Kliper
authors: Hen
authors: H
authors: Hallevi
authors: Ludmila
authors: L
authors: Shopin
authors: Talma
authors: T
authors: Hendler
authors: Dafna Ben
authors: DB
authors: Baashat
authors: Orna
authors: O
authors: Aizenstein
authors: Hermona
authors: H
authors: Soreq
authors: Noomi
authors: N
authors: Katz
authors: Zahava
authors: Z
authors: Solomon
authors: Anat
authors: A
authors: Mike
authors: Sali
authors: S
authors: Usher
authors: Jeff M
authors: JM
authors: Hausdorff
authors: Eitan
authors: E
authors: Auriel
authors: Itzhak
authors: I
authors: Shapira
authors: Natan M
authors: NM
authors: Bornstein
mesh_terms: D000368:Aged; D003072:Cognition Disorders / Q000209:etiology / Q000517:prevention & control; D003704:Dementia / Q000209:etiology; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D002546:Ischemic Attack, Transient / Q000150:complications* / Q000235:genetics; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000209:etiology / Q000517:prevention & control; D009460:Neurologic Examination; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D018401:Sample Size; D013315:Stress, Psychological / Q000209:etiology; D020521:Stroke / Q000150:complications* / Q000235:genetics
chemical_list: D005819:Genetic Markers