title: Secolignans, neolignans and phenylpropanoids from Daphne feddei and their biological activities.
abstract: Two new secolignans and one new neolignan, named feddeiphenols A-C (1-3), together with eight known compounds (4-11), were isolated from the leaves and stems of Daphne feddei. Their structures were established on the base of spectroscopic methods, mainly extensive NMR, UV spectroscopy, and MS spectrometry. Compounds 1-11 were tested for their anti-human immunodeficiency virus (HIV)-1 activity and cytotoxicity. The results revealed that compounds 1, 2, 3, 7, and 9 showed therapeutic index (TI) values above 30, respectively, and the other compounds also showed weak anti-HIV-1 activity. Compound 1 showed modest cytotoxic activity. The other compounds also showed weak cytotoxic activity.
authors: Key Laboratory of Ethnic Medicine Resource Chemistry (Yunnan University of Nationalities), State Ethnic Affairs Commission & Ministry of Education, Kunming 650031, PR China.
authors: Qiu-Fen
authors: QF
authors: Hu
authors: Huai-Xue
authors: HX
authors: Mu
authors: Hai-Tao
authors: HT
authors: Huang
authors: Hua-Ying
authors: HY
authors: Lv
authors: Shu-Li
authors: SL
authors: Li
authors: Pen-Fei
authors: PF
authors: Tu
authors: Gan-Peng
authors: GP
authors: Li
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D032364:Daphne / Q000737:chemistry*; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet
chemical_list: D019380:Anti-HIV Agents; D017705:Lignans; D010936:Plant Extracts; C570330:feddeiphenol A; C570331:feddeiphenol B; C570332:feddeiphenol C