title: Asymmetric cyanation of nitroalkenes catalyzed by a salen-titanium catalyst.
abstract: The salen-Ti complex catalyzed cyanation of nitroolefins was accomplished via the silyl nitronate intermediate for the synthesis of chiral β-nitronitriles with e.r. up to 92 : 8 and high yields (up to 90%). The catalyst also kept a high turnover frequency at room temperature. The yield and enantioselectivity of the protocol were slightly affected even in a 10 mmol scale.
authors: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou, 730000, P. R. China.
authors: Li
authors: L
authors: Lin
authors: Wen
authors: W
authors: Yin
authors: Xu
authors: X
authors: Fu
authors: Jinlong
authors: J
authors: Zhang
authors: Xiaojuan
authors: X
authors: Ma
authors: Rui
authors: R
authors: Wang
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D003486:Cyanides / Q000737:chemistry*; D005029:Ethylenediamines / Q000737:chemistry*; D009574:Nitro Compounds / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*
chemical_list: D000475:Alkenes; D003486:Cyanides; D005029:Ethylenediamines; D009574:Nitro Compounds; C011452:disalicylaldehyde ethylenediamine; D014025:Titanium