title: Absorption and excretion of ascorbic acid alone and in acerola (Malpighia emarginata) juice: comparison in healthy Japanese subjects.
abstract: It has been suggested that some food components, such as bioflavonoids, affect the bioavailability of ascorbic acid in humans. Since little is known in Japan about the effective intake of this dietary requirement, we tested young Japanese males after the ingestion of commercial ascorbic acid or acerola (Malpighia emarginata DC.) juice to compare the quantities absorbed and excreted. Healthy Japanese subjects received a single oral dose of ascorbic acid solution (50, 100, 200 or 500 mg) and received distilled water as a reference at intervals of 14 d or longer. All subjects were collected blood and urine until 6 h after ingestion and evaluated for time-dependent changes in plasma and urinary ascorbic acid levels. Predictably, the area under the curve (AUC) values in plasma and urine after ingestion increased dose-dependently. Next, each subject received diluted acerola juice containing 50 mg ascorbic acid. Likewise, their plasma and urinary ascorbic acid concentrations were measured. In plasma, the AUC value of ascorbic acid after ingestion of acerola juice tended to be higher than that from ascorbic acid alone. In contrast, the urinary excretion of ascorbic acid at 1, 2 and 5 h after ingestion of acerola juice were significantly less than that of ascorbic acid. These results indicate that some component of acerola juice favorably affected the absorption and excretion of ascorbic acid.
authors: Research and Development Division, Nichirei Foods Inc., Chiba, Japan.
authors: Eriko
authors: E
authors: Uchida
authors: Yoshitaka
authors: Y
authors: Kondo
authors: Akiko
authors: A
authors: Amano
authors: Shingo
authors: S
authors: Aizawa
authors: Takayuki
authors: T
authors: Hanamura
authors: Hitoshi
authors: H
authors: Aoki
authors: Kenichi
authors: K
authors: Nagamine
authors: Takeshi
authors: T
authors: Koizumi
authors: Naoki
authors: N
authors: Maruyama
authors: Akihito
authors: A
authors: Ishigami
mesh_terms: D000328:Adult; D019540:Area Under Curve; D001205:Ascorbic Acid / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D001628:Beverages; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000494:pharmacology; D018565:Food-Drug Interactions; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D007408:Intestinal Absorption; D007564:Japan; D008297:Male; D029581:Malpighiaceae / Q000737:chemistry*; D028321:Plant Preparations / Q000737:chemistry / Q000494:pharmacology*; D012016:Reference Values; D014815:Vitamins / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D055815:Young Adult
chemical_list: D005419:Flavonoids; D028321:Plant Preparations; D014815:Vitamins; D001205:Ascorbic Acid