title: Occupational exposures and risk of stomach cancer by histological type.
abstract: OBJECTIVE
  To explore the relationship between stomach cancer (SC), by histological type, and occupations and occupational exposures.
  
  
  METHODS
  The authors conducted a hospital-based case-control study in south-east Spain. Subjects were 399 incident histological confirmed SC cases (241 intestinal and 109 diffuse adenocarcinomas) and 455 controls frequency matched by sex, age and province of residence. Occupation was coded according to the Spanish National Classification of Occupations 1994. Occupational exposures were assessed by the FINJEM Job Exposure Matrix. ORs were estimated by unconditional logistic regression adjusting for matching variables and education, smoking, alcohol and diet.
  
  
  RESULTS
  In men, statistically significant increased risk of the diffuse subtype was found for 'cooks' (OR 8.02), 'wood-processing-plant operators' (OR 8.13) and 'food and related products machine operators' (OR 5.40); for the intestinal subtype, a borderline association was found for 'miners and quarry workers' (OR men 4.22, 95% CI 0.80 to 22.14). Significant increased risk was observed between the diffuse subtype of SC and the highest level of exposure to 'pesticides' (OR(H) both sexes 10.39, 95% CI 2.51 to 43.02, p(trend)=0.02) and between the intestinal subtype and asbestos (OR(H) men 3.71, 95% CI 1.40 to 9.83, p(trend)=0.07). Restricted analyses of exposures of 15 years and longer showed significant associations between the diffuse subtype and the exposure to 'wood dust' (OR men 3.05).
  
  
  CONCLUSIONS
  This study supports the relationship previously suggested between SC and occupational exposure to dusty and high temperature environments. Several occupations may also increase the risk of diffuse SC but not the intestinal subtype.
authors: Research Support Unit, IFIMAV-Fundación Marqués de Valdecilla, 39011 Santander, Spain. ifimav.eclinicos2@fmdv.org
authors: Miguel
authors: M
authors: Santibañez
authors: Juan
authors: J
authors: Alguacil
authors: Manuela García
authors: MG
authors: de la Hera
authors: Eva María
authors: EM
authors: Navarrete-Muñoz
authors: Javier
authors: J
authors: Llorca
authors: Nuria
authors: N
authors: Aragonés
authors: Timo
authors: T
authors: Kauppinen
authors: Jesús
authors: J
authors: Vioque
mesh_terms: D000230:Adenocarcinoma / Q000145:classification / Q000209:etiology / Q000473:pathology*; D000368:Aged; D000393:Air Pollutants / Q000009:adverse effects*; D001194:Asbestos / Q000009:adverse effects; D016022:Case-Control Studies; D003296:Cooking; D004391:Dust; D005260:Female; D019649:Food Industry; D006358:Hot Temperature; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D009790:Occupations; D016017:Odds Ratio; D010575:Pesticides / Q000009:adverse effects; D012307:Risk Factors; D012737:Sex Factors; D013030:Spain; D013274:Stomach Neoplasms / Q000145:classification / Q000209:etiology / Q000473:pathology*
chemical_list: D000393:Air Pollutants; D004391:Dust; D010575:Pesticides; D001194:Asbestos