title: Diverse tumor pathology due to distinctive patterns of JAK/STAT pathway activation caused by different Drosophila polyhomeotic alleles.
abstract: Drosophila polyhomeotic (ph) is one of the important polycomb group genes that is linked to human cancer. In the mosaic eye imaginal discs, while ph(del), a null allele, causes only non-autonomous overgrowth, ph(505), a hypomorphic allele, causes both autonomous and non-autonomous overgrowth. These allele-specific phenotypes stem from the different sensitivities of ph mutant cells to the Upd homologs that they secrete.
authors: Department of Entomology, University of Maryland, College Park, Maryland 20742, USA.
authors: Siqian
authors: S
authors: Feng
authors: Steffi
authors: S
authors: Thomas
authors: Jian
authors: J
authors: Wang
mesh_terms: D000483:Alleles; D000818:Animals; D049109:Cell Proliferation; D004268:DNA-Binding Proteins / Q000235:genetics*; D004330:Drosophila / Q000235:genetics* / Q000378:metabolism*; D029721:Drosophila Proteins / Q000235:genetics*; D005786:Gene Expression Regulation; D053612:Janus Kinases / Q000378:metabolism*; D009698:Nucleoproteins / Q000235:genetics*; D063150:Polycomb Repressive Complex 1; D051880:Receptors, Notch / Q000235:genetics / Q000378:metabolism; D050791:STAT Transcription Factors / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D009698:Nucleoproteins; D051880:Receptors, Notch; D050791:STAT Transcription Factors; C072820:ph-d protein, Drosophila; D063150:Polycomb Repressive Complex 1; D053612:Janus Kinases