title: Body temperature circadian rhythm variability corresponds to left ventricular systolic dysfunction in decompensated cardiomyopathic hamsters.
abstract: BACKGROUND
  A declining amplitude of body temperature circadian rhythm (BTCR) predicts decompensation or death in cardiomyopathic hamsters. We tested the hypothesis that changes in BTCR amplitude accompany significant changes in left ventricular (LV) size and function.
  
  
  RESULTS
  Using intraperitoneal transmitters, we continuously monitored the temperature of 30 male BIO TO-2 Syrian dilated cardiomyopathic hamsters. Cosinor analysis was used to detect significant changes--defined as changes >1 standard deviation from the baseline amplitude for 3 consecutive days--in BTCR amplitude over each hamster's lifespan. The Student t-test was used to compare BTCR variability and LV size and function (as assessed by 2D echocardiography) between baseline and the time that BTCR amplitude declined. All hamsters received 10 mg/kg furosemide daily. At the time of BTCR amplitude decline, functional parameters had changed significantly (P < .0001) from baseline: ejection fraction (0.31 ± 0.09% vs. 0.52 ± 0.08%), LV end-systolic volume (0.11 ± 0.03 vs. 0.05 ± 0.02 cm(3)), and LV end-diastolic volume (0.16 ± 0.04 vs. 0.10 ± 0.03 cm(3)).
  
  
  CONCLUSIONS
  In decompensated cardiomyopathic hamsters, a decline in BTCR amplitude was associated with progression of heart failure and cardiac decompensation. Variation in BTCR warrants further investigation because of its potential implications for the diagnosis and treatment of cardiovascular disorders.
authors: Texas Heart Institute at St. Luke's Episcopal Hospital, Houston, Texas, USA. Amany.H.Ahmed@uth.tmc.edu
authors: Amany
authors: A
authors: Ahmed
authors: Sreedevi
authors: S
authors: Gondi
authors: Casey
authors: C
authors: Cox
authors: Minjuan
authors: M
authors: Zheng
authors: Anwarullah
authors: A
authors: Mohammed
authors: Igor V
authors: IV
authors: Stupin
authors: Suwei
authors: S
authors: Wang
authors: Deborah
authors: D
authors: Vela
authors: Alan
authors: A
authors: Brewer
authors: Macarthur A
authors: MA
authors: Elayda
authors: L Maximilian
authors: LM
authors: Buja
authors: S
authors: S
authors: Ward Casscells
authors: James M
authors: JM
authors: Wilson
mesh_terms: D000818:Animals; D001831:Body Temperature; D002940:Circadian Rhythm / Q000502:physiology*; D006224:Cricetinae; D004195:Disease Models, Animal; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000473:pathology*; D016014:Linear Models; D008297:Male; D018570:Risk Assessment; D013599:Systole; D014463:Ultrasonography; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000473:pathology*