title: Blocking of acquisition of a taste aversion by a context experienced prior to the taste.
abstract: This experiment tested the proposal that events taking place before a rat has access to a taste can proactively interfere with acquisition of an aversion to the taste when this has been followed by lithium chloride injection. Rats were initially given context discrimination whereby placement in one distinctive context (target) was followed by lithium injection, while placement in a second context (safe) was followed by saline injection. In the subsequent 1-trial taste conditioning session, rats were first placed in either their target context (Blocking group), their safe context (Control-Safe group) or a neutral context (Control-Neutral group), then given access to sucrose and 30 min later were injected with lithium. Subsequent tests of sucrose intakes revealed a blocking effect. These results indicate that proactive interference with taste aversion learning by a context can occur that is unlikely to be based on generalization decrement.
authors: University of Sydney, NSW, Australia.
authors: Dorothy W S
authors: DW
authors: Kwok
authors: Robert A
authors: RA
authors: Boakes
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D003213:Conditioning, Psychological / Q000187:drug effects / Q000502:physiology*; D003463:Cues; D018021:Lithium Chloride / Q000494:pharmacology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013395:Sucrose / Q000494:pharmacology; D013649:Taste / Q000187:drug effects / Q000502:physiology*; D055697:Taste Perception / Q000187:drug effects / Q000502:physiology
chemical_list: D013395:Sucrose; D018021:Lithium Chloride