title: Treatment of pseudobulbar affect with citalopram in a patient with progressive multifocal leukoencephalopthy.
abstract: Pseudobulbar affect (PBA) manifests in a variety of neurologic illnesses suggesting a heterogeneous pathophysiology with common underpinnings. We report successful treatment of PBA with a selective serotonin reuptake inhibitor (SSRI) in a 54-year-old woman following progressive multifocal leukoencephalopathy (PML). In light of recent focus on dextromethorphan/quinidine (DM/Q) for the treatment of PBA, the clinician is reminded of the effectiveness of SSRIs.
authors: Department of Psychiatry, University of Western Ontario, London Health Sciences Centre, Victoria Hospital, 800 Commissioners Road, London, Ontario, Canada N6A 5W9.
authors: R R
authors: RR
authors: King
authors: J P
authors: JP
authors: Reiss
mesh_terms: D000342:Affective Symptoms / Q000188:drug therapy* / Q000209:etiology; D015283:Citalopram / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000150:complications / Q000473:pathology*; D008875:Middle Aged; D020828:Pseudobulbar Palsy / Q000188:drug therapy* / Q000209:etiology; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D015283:Citalopram; D017367:Selective Serotonin Reuptake Inhibitors