title: Total synthesis of hirsutellone B via Ullmann-type direct 13-membered macrocyclization.
abstract: Total synthesis of Hirsutellone B has been achieved by a convergent synthetic strategy. This synthesis features direct construction of the highly strained 13-membered macrocycle of Hirsutellone B utilizing the Ullmann-type reaction. To the best of our knowledge, this is the first application of macrocyclization utilizing an intramolecular Ullmann-type reaction between an aliphatic alcohol and aryl halide.
authors: Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda-shi, Chiba 278-8510, Japan. uchiro@rs.noda.tus.ac.jp
authors: Hiromi
authors: H
authors: Uchiro
authors: Ryo
authors: R
authors: Kato
authors: Yuuki
authors: Y
authors: Arai
authors: Miki
authors: M
authors: Hasegawa
authors: Yu
authors: Y
authors: Kobayakawa
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003500:Cyclization; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D013237:Stereoisomerism
chemical_list: D000995:Antitubercular Agents; D006576:Heterocyclic Compounds, 4 or More Rings; C545159:hirsutellone B