title: Association of single nucleotide polymorphisms in IL-12 and IL-27 genes with colorectal cancer risk.
abstract: OBJECTIVE
  Interleukin-12 (IL-12) plays an important role in antitumor immunity. Interleukin-27 (IL-27) is a novel IL-12 family member. The present studies demonstrate that IL-27 mediates potent antitumor activity. However, No studies have examined the association of these polymorphism with colorectal cancer (CRC). Therefore, we investigated the relationship of IL-12 and IL-27 gene polymorphisms and CRC.
  
  
  METHODS
  We analyzed polymorphisms of IL-12 gene 16974 A/C and IL-27 gene -964 A/G, 2905 T/G, 4730 T/C in 410 patients with CRC and 450 controls, using PCR-RFLP method.
  
  
  RESULTS
  There were no significant differences in the genotype and allele frequencies of IL-12 and IL-27 gene polymorphisms between the group of patients with CRC and the controls. Furthermore, no association was found between IL-12 family gene polymorphisms and different clinical stages in patients with CRC.
  
  
  CONCLUSIONS
  These findings suggest that IL-12 and IL-27 gene polymorphisms may not be involved in susceptibility to CRC.
authors: Department of Pathology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, Guangxi, China.
authors: Zhao-Quan
authors: ZQ
authors: Huang
authors: Jun-Li
authors: JL
authors: Wang
authors: Guo-Gang
authors: GG
authors: Pan
authors: Ye-Sheng
authors: YS
authors: Wei
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D002681:China; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006239:Haplotypes; D006801:Humans; D018664:Interleukin-12 / Q000235:genetics; D020381:Interleukin-17 / Q000235:genetics; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide
chemical_list: D020381:Interleukin-17; D018664:Interleukin-12