title: Manganese dioxide mediated one-pot synthesis of methyl 9H-pyrido[3,4-b]indole-1-carboxylate: Concise synthesis of alangiobussinine.
abstract: The carboline ring system is an important pharmacophore found in a number of biologically important targets. Development of synthetic routes for the preparation of these compounds is important in order to prepare a range of analogues containing the carboline heterocyclic moiety. A manganese dioxide mediated one-pot method starting with an activated alcohol and consisting of alcohol oxidation, Pictet-Spengler cyclisation, and oxidative aromatisation, offers a convenient process that allows access to β-carbolines. This one-pot process for the preparation of methyl 9H-pyrido[3,4-b]indole-1-carboxylate has subsequently been used as the key step in the synthesis of alangiobussinine and a closely related analogue.
authors: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 165 Cathedral Street, Glasgow, G4 0RE, UK.
authors: Jessica
authors: J
authors: Baiget
authors: Sabin
authors: S
authors: Llona-Minguez
authors: Stuart
authors: S
authors: Lang
authors: Simon P
authors: SP
authors: Mackay
authors: Colin J
authors: CJ
authors: Suckling
authors: Oliver B
authors: OB
authors: Sutcliffe