title: [Cigarette smoking as a promoting factor for nonspecific inflammatory bowel disease].
abstract: Nonspecific inflammatory bowel diseases represent serious and chronic pathologies of the gastrointestinal tract. Even though the etiology of these diseases has not been fully elucidated, it is known that environmental factors like cigarette smoking may induce and exacerbate their course. Many substances in cigarette smoke have a modulatory effect on the immune system through a change in the composition of pro-/anti-inflammatory cytokines witch plays its part in the development of inflammation. Moreover, cigarette smoke contains reactive oxygen species which may combine with decreased activity of antioxidant enzymes to produce an additional proinflammatory effect. It is interesting that cigarette smoke has a different effect on the course of Crohn's disease compared with ulcerative colitis.
authors: Zakład Chemii Medycznej, Pomorskiego Uniwersytetu Medycznego w Szczecinie, al. Powstańców Wlkp. 72, 70-111 Szczecin.
authors: Mariusz
authors: M
authors: Molenda
authors: Joanna
authors: J
authors: Bober
authors: Dobrosława
authors: D
authors: Stańkowska-Walczak
authors: Małgorzata
authors: M
authors: Stańczyk-Dunaj
mesh_terms: D003093:Colitis, Ulcerative / Q000209:etiology / Q000378:metabolism; D003424:Crohn Disease / Q000209:etiology / Q000378:metabolism; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000209:etiology* / Q000378:metabolism*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*