title: ["The inflammasomes"].
abstract: Inflammation is a host adaptational response to cell injury caused by various exogenous and endogenous stimuli. IL-1β, which is an important proinflammatory cytokine secreted at the site of cellular injury, plays an important role in inflammation. Inflammasome is an intracellular multi-protein complex that mediates caspase-1-dependent processing of IL-1β. In this review, inflammasome function and its dysregulation are discussed in relation to autoinflammatory diseases.
authors: Department of Molecular Pathology, Shinshu University Graduate School of Medicine.
authors: Junya
authors: J
authors: Masumoto
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology; D051017:Apoptosis Regulatory Proteins / Q000502:physiology; D053468:CARD Signaling Adaptor Proteins / Q000502:physiology; D002135:Calcium-Binding Proteins / Q000502:physiology; D002352:Carrier Proteins / Q000502:physiology; D020170:Caspase 1 / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000502:physiology; D004268:DNA-Binding Proteins; D056660:Hereditary Autoinflammatory Diseases / Q000209:etiology*; D006801:Humans; D058847:Inflammasomes / Q000737:chemistry / Q000502:physiology*; D018836:Inflammation Mediators; D053583:Interleukin-1beta / Q000378:metabolism* / Q000502:physiology; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D000070576:NLR Proteins; D009687:Nuclear Proteins / Q000502:physiology; D000071198:Pyrin
chemical_list: C410167:AIM2 protein, human; D048868:Adaptor Proteins, Signal Transducing; D051017:Apoptosis Regulatory Proteins; D053468:CARD Signaling Adaptor Proteins; D002135:Calcium-Binding Proteins; D002352:Carrier Proteins; D003598:Cytoskeletal Proteins; D004268:DNA-Binding Proteins; D058847:Inflammasomes; D018836:Inflammation Mediators; D053583:Interleukin-1beta; D047908:Intracellular Signaling Peptides and Proteins; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D000070576:NLR Proteins; C435692:NLRC4 protein, human; C427903:NLRP1 protein, human; C453881:NLRP3 protein, human; C468563:NLRP6 protein, human; D009687:Nuclear Proteins; D000071198:Pyrin; D020170:Caspase 1