title: Novel association of acid phosphatase locus 1*C allele with systemic lupus erythematosus.
abstract: The red cell acid phosphatase (ACP1) gene, which encodes a low-molecular-weight phosphotyrosine phosphatase, has been suggested as a common genetic factor of autoimmunity. In the present study, we aim to investigate the possible association of ACP1 with the susceptibility of systemic lupus erythematosus (SLE). A total of 1,546 SLE patients and 1,947 healthy individuals from 4 Caucasians populations were included in the present study. Four single-nucleotide polymorphisms (SNPs) were genotyped in this study: rs10167992, rs11553742, rs7576247, and rs3828329. ACP1*A, ACP1*B, and ACP1*C codominant ACP1 alleles were determined using 2 of the SNPs and analyzed. After the meta-analysis test was performed, a significant association of rs11553742*T was observed (p(pooled) = 0.005, odds ratios = 1.37 [1.10-1.70]), retaining significance after multiple testing was applied (p(FDR) = 0.019). Our data indicate for first time the association of rs11553742*T with increased susceptibility in SLE patients.
authors: Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, 18100 Armilla, Granada, Spain. mteruel@ipb.csic.es
authors: María
authors: M
authors: Teruel
authors: Jose-Ezequiel
authors: JE
authors: Martin
authors: Norberto
authors: N
authors: Ortego-Centeno
authors: Juan
authors: J
authors: Jiménez-Alonso
authors: Julio
authors: J
authors: Sánchez-Román
authors: Enrique
authors: E
authors: de Ramón
authors: M Francisca
authors: MF
authors: Gonzalez-Escribano
authors: Bernardo A
authors: BA
authors: Pons-Estel
authors: Sandra
authors: S
authors: D'Alfonso
authors: Gian Domenico
authors: GD
authors: Sebastiani
authors: Torsten
authors: T
authors: Witte
authors: Nunzio
authors: N
authors: Bottini
authors: Miguel A
authors: MA
authors: González-Gay
authors: Marta E
authors: ME
authors: Alarcón-Riquelme
authors: Javier
authors: J
authors: Martin
mesh_terms: D000483:Alleles; D001118:Argentina; D015331:Cohort Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D005858:Germany; D006239:Haplotypes; D006801:Humans; D007558:Italy; D015810:Linkage Disequilibrium; D008180:Lupus Erythematosus, Systemic / Q000208:ethnology / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D013030:Spain; D044465:White People / Q000235:genetics
chemical_list: D011518:Proto-Oncogene Proteins; C490429:ACP1 protein, human; D017027:Protein Tyrosine Phosphatases