title: Randomized clinical trial on the efficacy of Escherichia coli-derived rhBMP-2 with β-TCP/HA in extraction socket.
abstract: OBJECTIVE
  This randomized clinical trial was conducted to assess the safety and effectiveness of the ErhBMP-2 in alveolar bone regeneration as well as preservation of the β-TCP bone graft material that contains ErhBMP-2.
  
  
  METHODS
  This study involved 72 patients at the 3 study centers. The patients, who were divided into 2 groups: the experiment group who had ErhBMP-2 coated TCP/HA and the control group who had TCP/HA graft material alone transplanted immediately after tooth extraction. CT was taken before and 3 months after the transplantation and healing status was compared between the two groups. The efficacy endpoints that were used to measure the degree of bone induction included alveolar bone height and 3 measurements of bone width. The paired t test was used to determine the significance of the changes (P<.05).
  
  
  RESULTS
  Changes in alveolar bone height were -1.087 ± 1.413 mm in the control group and -.059 ± 0.960 mm in the experimental group (P<.01). At 25% extraction socket length [ESL], the changes were 0.006 ± 1.149 mm in the control group and 1.279 ± 1.387 mm in the experimental group. At 50% ESL, the changes were 0.542 ± 1.157 mm and 1.239 ± 1.249 mm, respectively (P<.01 for 25% ESL, and P<.05 for 50% ESL). During the experiment, no adverse reactions to the graft material were observed.
  
  
  CONCLUSIONS
  ErhBMP-2 coated β-TCP/HA were found to be more effective in preserving alveolar bone than conventional β-TCP/HA alloplastic bone graft materials.
authors: Department of Prosthodontics, School of Dentistry, Pusan National University, Yangsan, Korea.
authors: Jung-Bo
authors: JB
authors: Huh
authors: Hyo-Jung
authors: HJ
authors: Lee
authors: Ji-Woong
authors: JW
authors: Jang
authors: Myung-Jin
authors: MJ
authors: Kim
authors: Pil-Young
authors: PY
authors: Yun
authors: Su-Hong
authors: SH
authors: Kim
authors: Kyung-Hee
authors: KH
authors: Choi
authors: Young-Kyun
authors: YK
authors: Kim
authors: Kyoo-Sung
authors: KS
authors: Cho
authors: Sang-Wan
authors: SW
authors: Shin