title: The association of serum chemerin level with risk of coronary artery disease in Chinese adults.
abstract: Chemerin is a newly discovered adipokine which has been found closely associated with obesity, metabolic syndrome (MetS), and inflammatory status. This study will investigate whether serum chemerin levels are associated with coronary artery disease (CAD) independently of other cardiovascular risk factors. This study included a total of 430 subjects (239 with CAD and 191 with non-CAD) who underwent coronary angiography. Anthropometric measurements were performed and chemerin, glucose, lipid profiles, and other biochemical characteristics were measured. The severity of coronary atherosclerosis was estimated by the total number of diseased vessels and Gensini score. Serum chemerin levels were significantly higher in the CAD group than in the non-CAD group (P = 0.011). The odds ratios (95% CI) of CAD across increasing quartiles of serum chemerin were 1.04 (0.61-1.78), 1.08 (0.63-1.83), and 1.87 (1.07-3.24), (P = 0.386, 0.508, and 0.012, respectively). Adjusting for age, sex, and other conventional risk factors for CAD did not appreciably alter the results. Serum chemerin levels were significantly increased with an increasing of number of diseased vessels (P = 0.024). In conditional linear regression models, chemerin levels were positively related to Gensini score even after established cardiovascular risk factors (β = 0.13, P = 0.019). Correlation analysis showed serum chemerin levels were significantly associated with TG levels, TC levels, fasting serum insulin, HOMA-IR and MetS (all P < 0.05). Higher serum chemerin levels were associated with increased risk of CAD and metabolic parameters in Chinese adults. Chemerin may represent a novel link between metabolic signals and atherosclerosis.
authors: Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Rui-jin Hospital, Shanghai Jiao-Tong University School of Medicine, 197 Ruijin Er Road, Shanghai 200025, China.
authors: Qun
authors: Q
authors: Yan
authors: Yifei
authors: Y
authors: Zhang
authors: Jie
authors: J
authors: Hong
authors: Weiqiong
authors: W
authors: Gu
authors: Meng
authors: M
authors: Dai
authors: Juan
authors: J
authors: Shi
authors: Ying
authors: Y
authors: Zhai
authors: Weiqing
authors: W
authors: Wang
authors: Xiaoying
authors: X
authors: Li
authors: Guang
authors: G
authors: Ning
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D018925:Chemokines / Q000097:blood*; D002681:China / Q000453:epidemiology; D002784:Cholesterol / Q000097:blood; D015331:Cohort Studies; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications; D008875:Middle Aged; D012307:Risk Factors; D012720:Severity of Illness Index; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D018925:Chemokines; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human; D014280:Triglycerides; D002784:Cholesterol