title: Effects of low doses of gamma rays on the stability of normal and diabetic erythrocytes.
abstract: We studied the influence of low doses of γ radiation (from 0.04 to 1.8 mGy) on the stability of human red blood cells (RBC) from healthy donors and diabetic patients using absorption spectroscopy. Because of the alteration of many enzymatic pathways in diabetic RBCs resulting in strong modification of the lipid and protein membrane components one could expect that the ionizing γ-radiation should influence the stability of the healthy and diabetic cells in a different way. Indeed, distinct discontinuities and monotonic changes of hemolysis detected in the healthy and diabetic RBCs suggest that various enzymatic and chemical processes are activated in these membranes by γ radiation. Mössbauer measurements showed that only the highest applied dose of γ radiation caused modification of hemoglobin in both types of RBCs.
authors: AGH University of Science and Technology, Kraków, Poland.
authors: Magdalena
authors: M
authors: Kaczmarska
authors: Zofia
authors: Z
authors: Kopyściańska
authors: Maria
authors: M
authors: Fornal
authors: Tomasz
authors: T
authors: Grodzicki
authors: Krzysztof
authors: K
authors: Matlak
authors: Józef
authors: J
authors: Korecki
authors: Květoslava
authors: K
authors: Burda
mesh_terms: D021961:Cell Membrane Structures / Q000737:chemistry / Q000528:radiation effects; D003920:Diabetes Mellitus / Q000097:blood*; D004910:Erythrocyte Membrane / Q000737:chemistry / Q000528:radiation effects; D004912:Erythrocytes / Q000737:chemistry / Q000528:radiation effects*; D005720:Gamma Rays; D006454:Hemoglobins / Q000737:chemistry / Q000528:radiation effects; D006461:Hemolysis; D006706:Homeostasis; D006801:Humans; D015227:Lipid Peroxidation; D018384:Oxidative Stress; D013054:Spectrophotometry, Atomic / Q000379:methods; D013997:Time Factors
chemical_list: D006454:Hemoglobins