title: The rs553668 polymorphism of the ADRA2A gene predicts the worsening of fasting glucose values in a cohort of subjects without diabetes. A population-based study.
abstract: OBJECTIVE
  Single-nucleotide polymorphisms in the human ADRA2A gene have been associated with increased risk of Type 2 diabetes. The associations between the rs553668 polymorphism and fasting glucose concentrations both cross-sectionally and longitudinally after 6-year follow-up were evaluated in an adult Caucasian population-based cohort.
  
  
  METHODS
  From a cohort of 1658 individuals, after excluding patients with diabetes, those who died and those whose blood samples were not available for genotyping, data of 1345 individuals were analysed.
  
  
  RESULTS
  Subjects homozygous for the A allele showed significantly increased baseline fasting glucose values and a significant worsening of fasting glucose (β = 0.48; 95% CI 0.10-0.86) and insulin secretion (β =-20.75; -32.67 to -8.82 for homeostasis model assessment for β-cell function) at follow-up by using generalized estimating equations. Incidence of impaired fasting glucose and diabetes was almost twofold higher in subjects homozygous for the A allele (respectively: incident impaired fasting glucose 7.6-8.2, 16.1%, incident diabetes 1.7-2.3, 3.2% in GG, AG, AA carriers).
  
  
  CONCLUSIONS
  Our results suggested that the rs553668 polymorphism is associated with glucose worsening in subjects without diabetes at baseline.
authors: Department of Internal Medicine, University of Torino, Turin, Italy.
authors: S
authors: S
authors: Bo
authors: M
authors: M
authors: Cassader
authors: P
authors: P
authors: Cavallo-Perin
authors: M
authors: M
authors: Durazzo
authors: R
authors: R
authors: Rosato
authors: R
authors: R
authors: Gambino
mesh_terms: D001786:Blood Glucose / Q000235:genetics*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics* / Q000503:physiopathology; D018450:Disease Progression; D005215:Fasting / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011236:Prediabetic State / Q000097:blood / Q000235:genetics* / Q000503:physiopathology; D011237:Predictive Value of Tests; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: C547768:ADRA2A protein, human; D001786:Blood Glucose; D018341:Receptors, Adrenergic, alpha-2