title: New tigliane-type diterpenoids from Euphorbia aellenii Rech. f. with immunomodulatory activity.
abstract: The cytotoxic chloroform fraction of Euphorbia aellenii Rech. F. (Euphorbiaceae) afforded two new phorbol diterpenoids: 4-deoxy-4α-phorbol-12-(2,3-dimethyl) butyrate-13-isobutyrate and 17-hydroxy-4-deoxy-4α-phorbol-12-(2,3-dimethyl) butyrate-13-isobutyrate. Their structures were elucidated by NMR and other spectroscopic methods. The immunomodulating potentials of the isolated compounds were tested using standard proliferation and chemiluminescence assays. Compound 2 showed moderate inhibitory activity against both T-cell proliferation and reactive oxygen species (ROS) production in whole blood with IC50 of 14.0 ± 0.57 and 44.1 ± 3.8 μg/ml, respectively, while compound 1 was relatively inactive with IC50 >50 μg/mL for T-cell proliferation, and >100 μg/mL for ROS.
authors: Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, I.R.Iran.
authors: M
authors: M
authors: Ghanadian
authors: A M
authors: AM
authors: Ayatollahi
authors: M A
authors: MA
authors: Mesaik
authors: S
authors: S
authors: Afsharypuor
authors: O M
authors: OM
authors: Abdalla
authors: F
authors: F
authors: Kobarfard