title: Allele frequencies for 15 autosomal STR markers in the Libyan population.
abstract: BACKGROUND
  Until recently Libya remained the only state of the Maghreb without genetic evolution investigations of the genetic landscape of its population. Apart from some studies of Libyan Jews and Libyan Tuareg, only two recent investigations, based on autosomal ancestry informative SNP and mitochondrial DNA markers, have concerned the general Libyan population.
  
  
  OBJECTIVE
  The present work is the first to describe STR markers polymorphism in the general Libyan population in order to contribute to the analysis of its genetic diversity for forensic purposes.
  
  
  METHODS
  Allele frequencies for 15 STR loci (CSF1PO, D3S1358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S51, D21S11, FGA, TH01, TPOX, VWA, D2S1338, D19S433) included in the AmpFlSTR Identifiler kit were determined in a sample of 99 unrelated individuals originating from the general Libyan population.
  
  
  RESULTS
  No deviations from Hardy-Weinberg equilibrium were observed, with the exception of CSF1PO. Genetic parameters of forensic interest such as combined power of discrimination (PD) and combined probability of exclusion (PE) showed values higher than 0.999. Comparisons with data from other North African populations showed significant differences between Libyans and Tunisians, Moroccans and Egyptians.
  
  
  CONCLUSIONS
  The high informativity observed for these 15 STRs in a Libyan population demonstrates their usefulness for forensic and parental purposes.
authors: Laboratory of Molecular Genetics, Immunology and Human Pathologies, Faculty of Sciences, University of Tunis El Manar, Tunis, Tunisia. housseinkek@yahoo.fr
authors: Houssein
authors: H
authors: Khodjet-el-Khil
authors: Karima
authors: K
authors: Fadhlaoui-Zid
authors: Leonor
authors: L
authors: Gusmão
authors: Cíntia
authors: C
authors: Alves
authors: Amel
authors: A
authors: Benammar-Elgaaied
authors: António
authors: A
authors: Amorim
mesh_terms: D002877:Chromosomes, Human / Q000235:genetics*; D053803:Forensic Genetics; D005787:Gene Frequency / Q000235:genetics*; D056426:Genetic Loci / Q000235:genetics; D005819:Genetic Markers; D014644:Genetic Variation; D005828:Genetics, Population; D006801:Humans; D008002:Libya; D020080:Tandem Repeat Sequences / Q000235:genetics*
chemical_list: D005819:Genetic Markers