title: Ganglia/nerve fibers ratio correlates with the need for surgery in patients diagnosed with Hirschsprung's disease allied disorder (HAD).
abstract: Treatment in Hirschsprung's disease allied disorder (HAD) is surgical. In HAD, surgery is always a question. We investigated the value of ganglia/nerve fibers ratio in prediction of the need for invasive procedures in HAD. Sections of full thickness bowel specimens of 14 patients were stained with antibodies marking ganglia (Anti-Neuron-Specific Enolase, Anti-NSE) and marking nerve fibers (S-100). Six out of seven patients indicated for surgery had low ganglia/nerve fibers ratio. Five out of seven patients, not showing the need for surgery, had high ganglia/nerve fibers ratio. We propose that a lower ganglia/nerve fiber ratio can be used as a predictor of increased need for surgery in HAD.
authors: Department of Pathology, Clinical Hospital Centre of Rijeka, Rijeka, Croatia. iva.gasparovic@ri.t-com.hr
authors: Iva
authors: I
authors: Gasparovic
authors: Drazen
authors: D
authors: Kovac
authors: Mladen
authors: M
authors: Persic
authors: Irena
authors: I
authors: Slavic
authors: Harry
authors: H
authors: Nikolic
authors: Nives
authors: N
authors: Jonjic
mesh_terms: D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005724:Ganglia / Q000473:pathology; D006627:Hirschsprung Disease / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009412:Nerve Fibers / Q000473:pathology; D012007:Rectum / Q000294:innervation / Q000473:pathology