title: Cranberry as promising natural source of potential anticancer agents: current evidence and future perspectives.
abstract: BACKGROUND
  Accumulating evidence suggest that dietary modification can lower the risk for several cancer types' development. Cranberry in particular, has been shown to have anti-oxidative, -inflammatory and -proliferative properties in vitro.
  
  
  OBJECTIVE
  To present the latest knowledge regarding the role of cranberry extracts against human cancer several types.
  
  
  METHODS
  A review of the literature documenting both in vitro and in vivo anti-cancer effects of whole cranberry and/or its extracts is conducted.
  
  
  CONCLUSIONS
  Current data provide evidence for several anti-cancer properties of either whole cranberry and/or its extracts. The discovery of the specific cranberry components and the appropriate concentrations that exert such beneficial effects along with verification of the preliminary in vitro results in in vivo settings could potentially lead to the invention of novel safer and efficient anti-cancer therapeutic agents.
authors: Department of Forensic Medicine and Toxicology, Medical School, University of Athens, 75 Mikras Asias Street, Athens 11527,Greece.
authors: Athanasios
authors: A
authors: Katsargyris
authors: Ekaterini-Christina
authors: EC
authors: Tampaki
authors: Constantinos
authors: C
authors: Giaginis
authors: Stamatios
authors: S
authors: Theocharis
mesh_terms: D000872:Anthocyanins / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D005419:Flavonoids / Q000494:pharmacology; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry; D014315:Triterpenes / Q000494:pharmacology; D029799:Vaccinium macrocarpon / Q000737:chemistry*; D000097245:Ursolic Acid
chemical_list: D000872:Anthocyanins; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D005419:Flavonoids; D010936:Plant Extracts; D014315:Triterpenes; D000097245:Ursolic Acid