title: A quarter century of granzymes.
abstract: Granzymes (Grs) were discovered just over a quarter century ago. They are produced by cytotoxic T cells and natural killer cells and are released upon interaction with target cells. Intensive biochemical, genetic, and biological studies have been performed in order to study their roles in immunity and inflammation. This review summarizes research on the family of Grs.
authors: Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.
authors: C L
authors: CL
authors: Ewen
authors: K P
authors: KP
authors: Kane
authors: R C
authors: RC
authors: Bleackley
mesh_terms: D000818:Animals; D017209:Apoptosis; D053148:Caspase 3 / Q000235:genetics / Q000378:metabolism; D053804:Granzymes / Q000235:genetics / Q000266:history / Q000502:physiology*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007109:Immunity / Q000235:genetics; D007249:Inflammation / Q000235:genetics / Q000276:immunology*; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology*; D051379:Mice; D054353:Perforin / Q000235:genetics / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology / Q000276:immunology*
chemical_list: D054353:Perforin; D053804:Granzymes; D053148:Caspase 3