title: [Optimization of ultrasonic-assisted extraction of total flavonoids from leaves of the Artocarpus heterophyllus by response surface methodology].
abstract: OBJECTIVE
  To investigate the ultrasonic-assisted extract on of total flavonoids from leaves of the Artocarpus heterophyllus.
  
  
  METHODS
  Investigated the effects of ethanol concentration, extraction time, and liquid-solid ratio on flavonoids yield. A 17-run response surface design involving three factors at three levels was generated by the Design-Expert software and experimental data obtained were subjected to quadratic regression analysis to create a mathematical model describing flavonoids extraction.
  
  
  RESULTS
  The optimum ultrasonic assisted extraction conditions were: ethanol volume fraction 69.4% and liquid-solid ratio of 22.6:1 for 32 min. Under these optimized conditions, the yield of flavonoids was 7.55 mg/g.
  
  
  CONCLUSIONS
  The Box-Behnken design and response surface analysis can well optimize the ultrasonic-assisted extraction of total flavonoids from Artocarpus heterophyllus.
authors: School of Chemistry & Chemical Engineering, Zhaoqing University, Zhaoqing 526061, China. hwwang@zqu.edu.cn
authors: Hong-wu
authors: HW
authors: Wang
authors: Yan-qing
authors: YQ
authors: Liu
authors: Yuan-hong
authors: YH
authors: Wang
mesh_terms: D000704:Analysis of Variance; D031622:Artocarpus / Q000737:chemistry*; D000431:Ethanol / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification*; D008962:Models, Theoretical; D018515:Plant Leaves / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*; D013997:Time Factors; D014465:Ultrasonics
chemical_list: D005419:Flavonoids; D000431:Ethanol