title: Prognostic significance of cytosolic phospholipase A2 expression in patients with colorectal cancer.
abstract: OBJECTIVE
  Cyclooxygenase-2 is believed to be an important enzyme in the pathogenesis of colorectal cancer (CRC). Cytosolic phospholipase A2 (cPLA2), also, have been suggested to be related to the carcinogenesis of CRC. The aim of this study was to investigate cPLA2 expression and its relationship with prognostic significance in CRC.
  
  
  METHODS
  Eighty-eight patients with colorectal cancer who underwent curative surgery were enrolled in this study. cPLA2 was examined in 88 primary CRCs by immunohistochemistry and we compared their expression with clinicopathologic findings, recurrence and survival in patients with CRC.
  
  
  RESULTS
  The expression of cPLA2 was positive in 54.5% (48/88). The expression of cPLA2 was not correlated with clinicopathologic parameters. However, cPLA2 expression was significantly related with vascular endothelial growth factor expression. Kaplan-Meier analysis didn't show any clinical significance in disease-free survival and overall survival according to cPLA2 expression.
  
  
  CONCLUSIONS
  These results suggest that cPLA2 expression was not associated with the prognosis of CRC. However, further large-scale studies are needed to clarify the prognostic effect of cPLA2 in CRC.
authors: Department of Surgery, Chosun University College of Medicine, Gwangju, Korea.
authors: Young Sun
authors: YS
authors: Yoo
authors: Sung Chul
authors: SC
authors: Lim
authors: Kyung Jong
authors: KJ
authors: Kim