title: Increased expression of CD146 and microvessel density (MVD) in invasive micropapillary carcinoma of the breast: Comparative study with invasive ductal carcinoma-not otherwise specified.
abstract: Invasive micropapillary carcinoma (IMPC) is a rare variant of ductal carcinoma of the breast, and is characterized by a high metastatic potential and an aggressive clinical course. Studies of CD146 expression and function in breast cancer remain scarce. The aim of this study was to evaluate the role of CD146 and microvessel density (MVD) in breast IMPC. CD146 mRNA expression and immunohistochemistry for CD146 and MVD measured by CD31 were assessed in 82 cases of IMPC and 137 cases of invasive ductal carcinoma, not otherwise specified (IDC-NOS). The mRNA level of CD146 in cancer specimens was higher in IMPC than in IDC-NOS. CD146 expression in tumor cells was up-regulated in IMPC as compared with that in IDC-NOS, and was positively correlated with histological grade, ER, PR status, and P53 expression in IMPC and IDC-NOS. CD146 expression in vascular endothelial cells was significantly higher than that in IDC, and was positively correlated with tumor progression in IMPC and IDC-NOS. MVD in IMPC was significantly higher than that in IDC. CD146 expression in tumor cells was positively correlated with that in vascular endothelial cells of IMPC and IDC-NOS. The association of CD146 expression with MVD and its correlation with progression in breast carcinoma indicated that CD146 is a potentially useful prognostic marker for breast cancer. CD146 could be a new drug target in the treatment of breast cancer.
authors: Department of Breast Cancer Pathology, Research Laboratory of Tianjin Medical University Cancer Institution and Hospital, Huan Hu Xi Road, Tiyuan Bei, Hexi District, Tianjin 300060, China.
authors: Weidong
authors: W
authors: Li
authors: Dongling
authors: D
authors: Yang
authors: Shuling
authors: S
authors: Wang
authors: Xiaojing
authors: X
authors: Guo
authors: Ronggang
authors: R
authors: Lang
authors: Yu
authors: Y
authors: Fan
authors: Feng
authors: F
authors: Gu
authors: Xinmin
authors: X
authors: Zhang
authors: Yun
authors: Y
authors: Niu
authors: Xiyun
authors: X
authors: Yan
authors: Li
authors: L
authors: Fu
mesh_terms: D000328:Adult; D000368:Aged; D001940:Breast / Q000378:metabolism / Q000473:pathology; D001943:Breast Neoplasms / Q000098:blood supply* / Q000378:metabolism* / Q000473:pathology; D051929:CD146 Antigen / Q000032:analysis / Q000235:genetics / Q000378:metabolism; D018270:Carcinoma, Ductal, Breast / Q000098:blood supply* / Q000378:metabolism* / Q000473:pathology; D002291:Carcinoma, Papillary / Q000098:blood supply* / Q000378:metabolism* / Q000473:pathology; D042783:Endothelial Cells / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis / Q000473:pathology; D055806:Microvessels / Q000473:pathology; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism
chemical_list: D051929:CD146 Antigen; C497902:MCAM protein, human; D019408:Platelet Endothelial Cell Adhesion Molecule-1