title: Edaravone, a free radical scavenger, attenuates behavioral deficits following transient forebrain ischemia by inhibiting oxidative damage in gerbils.
abstract: The present study investigates the neurological protective effects of edaravone against global brain ischemia. Gerbils were treated with edaravone (3mg/kg; i.p.) 30min before transient forebrain ischemia, which was induced by occluding the bilateral common carotid artery for 5min. The effects of edaravone were examined by measuring neuronal damage and behavioral deficits. Hexanoyl-lysine adduct (HEL) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), oxidative stress markers, were also examined to assess the anti-oxidative effects of edaravone. Edaravone treatment significantly inhibited both lipid and DNA oxidative damage 72h after ischemia, and decreased neuronal damage. Edaravone also significantly reduced the locomotor activity deficit 72h after ischemia and improved memory impairment. These findings suggest that edaravone inhibits oxidative stress and attenuates neuronal damage induced by transient forebrain ischemia in gerbils and which may contribute to improvements in behavioral deficits.
authors: Department of Neurobiology, Kagawa University Faculty of Medicine, Miki, Japan.
authors: Feng
authors: F
authors: Lu
authors: Takehiro
authors: T
authors: Nakamura
authors: Tetsuhiko
authors: T
authors: Toyoshima
authors: Yanan
authors: Y
authors: Liu
authors: Kazuyuki
authors: K
authors: Hirooka
authors: Nobuyuki
authors: N
authors: Kawai
authors: Naohiko
authors: N
authors: Okabe
authors: Fumio
authors: F
authors: Shiraga
authors: Takashi
authors: T
authors: Tamiya
authors: Osamu
authors: O
authors: Miyamoto
authors: Richard F
authors: RF
authors: Keep
authors: Toshifumi
authors: T
authors: Itano
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000704:Analysis of Variance; D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D001526:Behavioral Symptoms / Q000188:drug therapy* / Q000209:etiology*; D004249:DNA Damage / Q000187:drug effects / Q000502:physiology; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000378:metabolism; D004195:Disease Models, Animal; D000077553:Edaravone; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D005849:Gerbillinae; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology; D020287:In Situ Nick-End Labeling; D002546:Ischemic Attack, Transient / Q000150:complications*; D008239:Lysine / Q000031:analogs & derivatives / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D016548:Prosencephalon / Q000473:pathology*; D013997:Time Factors
chemical_list: D016166:Free Radical Scavengers; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine; D008239:Lysine; D000077553:Edaravone; D000983:Antipyrine