title: Exposure to high dosage trihexyphenidyl during pregnancy for treatment of generalized dystonia: case report and literature review.
abstract: BACKGROUND
  Trihexyphenidyl is 1 of the most effective agents for treatment of young-onset dystonia. As such, women of childbearing potential use trihexyphenidyl despite inadequate information about potential effects on pregnancy, labor, and fetal development.
  
  
  METHODS
  We report 2 uncomplicated pregnancies in 1 woman with early-onset, sporadic, primary generalized dystonia (DYT1 negative) treated with high dosage trihexyphenidyl and review the literature on antidystonic agents and pregnancy.
  
  
  CONCLUSIONS
  Although there is limited data, our case demonstrates that high-dosage trihexyphenidyl treatment is not necessarily a contraindication to pregnancy.
authors: Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA. Brobottom@som.umaryland.edu
authors: Bradley James
authors: BJ
authors: Robottom
authors: Stephen G
authors: SG
authors: Reich
mesh_terms: D000293:Adolescent; D000328:Adult; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D020821:Dystonic Disorders / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D014282:Trihexyphenidyl / Q000627:therapeutic use*
chemical_list: D000978:Antiparkinson Agents; D014282:Trihexyphenidyl