title: Insulin-dependent diabetes mellitus associated with presumed autoimmune polyendocrine syndrome in a mare.
abstract: A 5-year-old Thoroughbred-cross mare was diagnosed with insulin-dependent diabetes mellitus. Partial glycemic control and clinical improvement were achieved with daily insulin administration for 18 mo. The mare subsequently developed evidence of hypoadrenocorticism and died. Necropsy findings included lymphocytic infiltration of the pancreas, adrenal cortex, adrenal medulla, and thyroid glands, suggestive of an immune-mediated polyendocrinopathy.
authors: The Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, California, USA.
authors: Jill K
authors: JK
authors: Giri
authors: K Gary
authors: KG
authors: Magdesian
authors: Patricia M
authors: PM
authors: Gaffney
mesh_terms: D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D017809:Fatal Outcome; D005260:Female; D006734:Horse Diseases / Q000175:diagnosis / Q000188:drug therapy*; D006736:Horses; D016884:Polyendocrinopathies, Autoimmune / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*