title: Protein structural domains: definition and prediction.
abstract: Recognition and prediction of structural domains in proteins is an important part of structure and function prediction. This unit lists the range of tools available for domain prediction, and describes sequence and structural analysis tools that complement domain prediction methods. Also detailed are the basic domain prediction steps, along with suggested strategies for different protein sequences and potential pitfalls in domain boundary prediction. The difficult problem of domain orientation prediction is also discussed. All the resources necessary for domain boundary prediction are accessible via publicly available Web servers and databases and do not require computational expertise.
authors: Spanish National Cancer Research Centre (CNIO)-Structural Biology and Biocomputing Programme, Madrid, Spain.
authors: Iakes
authors: I
authors: Ezkurdia
authors: Spanish National Cancer Research Centre (CNIO)-Structural Biology and Biocomputing Programme, Madrid, Spain.
authors: Michael L
authors: ML
authors: Tress
mesh_terms: D019295:Computational Biology; D030562:Databases, Protein; D008954:Models, Biological; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry*; D012984:Software; D040681:Structural Homology, Protein
chemical_list: D011506:Proteins