title: Bipolar depression: an evidence-based approach.
abstract: Bipolar disorder is a complex, multidimensional illness that is often difficult to treat. Unfortunately, bipolar patients are much more likely to experience depression, which is all too often severe and a potentially lethal phase of the illness. In addition, pharmacotherapies with strong evidence for bipolar depression are limited. Most treatments are based on unsupported extrapolation from the treatment of unipolar depression or are derived largely from the clinical practice experience. In this article, we focus on the treatment of bipolar depression, with particular focus on evidence from the existing literature, to help guide readers in clinical practice.
authors: Department of Psychiatry, University of Pennsylvania Medical Center, 3535 Market Street, 2nd Floor, Philadelphia, PA 19104, USA. cfb@mail.med.upenn.edu
authors: Claudia F
authors: CF
authors: Baldassano
authors: Alexander
authors: A
authors: Hosey
authors: Jordan
authors: J
authors: Coello
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D018692:Antimanic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy*; D019317:Evidence-Based Medicine; D006801:Humans
chemical_list: D000928:Antidepressive Agents; D018692:Antimanic Agents