title: Subversion of innate immune responses by bacterial hindrance of NF-κB pathway.
abstract: Bacterial infections cause substantial mortality and burden of disease globally. Induction of a strong innate inflammatory response is the first common host mechanism required for elimination of the invading pathogens. The host transcription factor, nuclear factor kappa B (NF-κB) is essential for immune activation. Conversely, bacterial pathogens have evolved strategies to interfere directly with host cell signalling by regulating or mimicking host proteins. Given the key role of NF-κB in the host inflammatory response, bacteria have expectedly developed virulence effectors interfering with NF-κB signalling pathways. In this review, we explore the bacterial mechanisms utilized to prevent effective NF-κB signalling, which in turn usurp the host inflammatory response.
authors: Institute of Medical Microbiology and Hospital Hygiene, Heinrich Heine University, Düsseldorf, Germany. Gaelle.LeNegrate@uniduesseldorf.de
authors: Gaëlle
authors: G
authors: Le Negrate
mesh_terms: D000818:Animals; D001419:Bacteria / Q000276:immunology* / Q000472:pathogenicity*; D001426:Bacterial Proteins / Q000378:metabolism; D006801:Humans; D057131:Immune Evasion; D007113:Immunity, Innate; D008954:Models, Biological; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D037521:Virulence Factors / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D016328:NF-kappa B; D037521:Virulence Factors