title: NetB, a pore-forming toxin from necrotic enteritis strains of Clostridium perfringens.
abstract: The Clostridium perfringens necrotic enteritis B-like toxin (NetB) is a recently discovered member of the β-barrel pore-forming toxin family and is produced by a subset of avian C. perfringens type A strains. NetB is cytotoxic for avian cells and is associated with avian necrotic enteritis. This review examines the current state of knowledge of NetB: its role in pathogenesis, its distribution and expression in C. perfringens and its vaccine potential.
authors: CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia. Anthony. Keyburn@csiro.au
authors: Anthony L
authors: AL
authors: Keyburn
authors: Trudi L
authors: TL
authors: Bannam
authors: Robert J
authors: RJ
authors: Moore
authors: Julian I
authors: JI
authors: Rood
mesh_terms: D000818:Animals; D001427:Bacterial Toxins / Q000235:genetics / Q000276:immunology / Q000633:toxicity*; D001428:Bacterial Vaccines; D003016:Clostridium perfringens / Q000472:pathogenicity; D004751:Enteritis / Q000209:etiology*; D006801:Humans; D009336:Necrosis / Q000209:etiology*
chemical_list: D001427:Bacterial Toxins; D001428:Bacterial Vaccines; C572202:NE B-like toxin, Clostridium perfringens