title: Structural and biophysical determinants of αβ T-cell antigen recognition.
abstract: The molecular rules that govern MHC restriction, and allow T-cells to differentiate between peptides derived from healthy cells and those from diseased cells, remain poorly understood. Here we provide an overview of the structural constraints that enable the T-cell receptor (TCR) to discriminate between self and non-self peptides, and summarize studies that have attempted to correlate the biophysical parameters of TCR/peptide-major histocompatibility complex (pMHC) binding with T-cell activation. We further review how the antigenic origin of peptide epitopes affects TCR binding parameters and the 'quality' of a T-cell response. Understanding the principles that govern pMHC recognition by T-cells will unlock pathways to the rational development of immunotherapeutic approaches for the treatment of infectious disease, cancer and autoimmunity.
authors: Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, UK.
authors: John S
authors: JS
authors: Bridgeman
authors: Andrew K
authors: AK
authors: Sewell
authors: John J
authors: JJ
authors: Miles
authors: David A
authors: DA
authors: Price
authors: David K
authors: DK
authors: Cole
mesh_terms: D001324:Autoantigens / Q000276:immunology*; D015551:Autoimmunity / Q000276:immunology; D015704:CD4 Antigens / Q000276:immunology; D016827:CD8 Antigens / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D008285:Major Histocompatibility Complex / Q000235:genetics / Q000276:immunology; D010455:Peptides / Q000276:immunology; D011487:Protein Conformation; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000737:chemistry / Q000235:genetics / Q000276:immunology*
chemical_list: D001324:Autoantigens; D015704:CD4 Antigens; D016827:CD8 Antigens; D010455:Peptides; D016693:Receptors, Antigen, T-Cell, alpha-beta