title: [Effects of the overlapping between an experimental model of neuroendocrine obesity with arterial hypertension under blood pressure, body weight and metabolic and renal parameters in rats].
abstract: BACKGROUND
  Increased body mass index and the metabolic syndrome are associated with decreased renal function and the development of end-stage kidney disease.
  
  
  OBJECTIVE
  To evaluate the effect of the overlap between an experimental model of obesity and genetic hypertension on the blood pressure, body weight and metabolic and kidney parameters of rats.
  
  
  METHODS
  We studied male rats of the Wistar (WST) and spontaneously hypertensive rats (SHR) strains. Monosodium glutamate (MSG) was administered in the neonatal period to both strains, to make up two groups: WST + MSG and SHR + MSG. Animals in the control groups (WST and SHR) received saline. After completing three months of life, a 12-week follow-up period ensued, during which bi-weekly measurements of body weight (BW) and tail-cuff blood pressure (TCBP) were obtained. Microalbuminuria was analyzed at weeks 0, 4, 8 and 12. At the end of the follow-up period, blood was obtained for fasting glucose, plasma creatinine, and lipid profile determinations. The kidneys were removed, stained, and the glomerular sclerosis index was calculated.
  
  
  RESULTS
  The administration of MSG produced higher percentage body weight gain, higher fasting blood glucose and a higher degree of glomerular injury in WST-MSG and MSG-SHR rats, compared to their controls. Greater urinary albumin excretion was observed in SHR + MSG rats, when compared to SHR. There was no statistical difference in the TCBP, creatinine, and lipid profile.
  
  
  CONCLUSIONS
  The association of neuroendocrine obesity and arterial hypertension promoted morphological and functional changes in the glomerulus. These changes were more severe than those observed in hypertensive-only rats.
authors: Universidade Federal de São Paulo.
authors: Lara Beatriz Delfino
authors: LB
authors: Ferreira
authors: Mario Luis Ribeiro
authors: ML
authors: Cesaretti
authors: Aline Francisco
authors: AF
authors: Voltera
authors: Milton
authors: M
authors: Ginoza
authors: Osvaldo
authors: O
authors: Kohlmann
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001835:Body Weight; D004195:Disease Models, Animal; D006973:Hypertension / Q000378:metabolism* / Q000503:physiopathology*; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D009490:Neurosecretory Systems; D009765:Obesity / Q000378:metabolism* / Q000503:physiopathology*; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar