title: Genome-wide analysis of mitral valve disease in Cavalier King Charles Spaniels.
abstract: The Cavalier King Charles Spaniel (CKCS) is prone to severe early onset mitral valve disease. In this study, 36 purebred CKCS dogs were evaluated for mitral valve murmur and divided into early and late onset groups. A genome-wide genetic approach was used to assess whether the condition is determined by a small number of genetic factors. There were no regions of highly discrepant homo/heterozygosity in the two groups. Similarly, there was no evidence for loci associated with mitral valve murmur in a genome-wide association study. This analysis suggests that familial occurrence of mitral valve murmur in the CKCS breed is not due to a single major gene effect, indicating that breeding strategies to eliminate the disease cannot be based on genotype information at this time.
authors: Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Easter Bush, Roslin, Midlothian EH25 9RG, UK.
authors: Anne T
authors: AT
authors: French
authors: Rob
authors: R
authors: Ogden
authors: Cathlene
authors: C
authors: Eland
authors: Gibran
authors: G
authors: Hemani
authors: Ricardo
authors: R
authors: Pong-Wong
authors: Brendan
authors: B
authors: Corcoran
authors: Kim M
authors: KM
authors: Summers
mesh_terms: D000367:Age Factors; D000818:Animals; D001947:Breeding; D002874:Chromosome Mapping / Q000662:veterinary; D004283:Dog Diseases / Q000453:epidemiology / Q000235:genetics*; D004285:Dogs; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D055106:Genome-Wide Association Study / Q000662:veterinary; D006326:Heart Auscultation / Q000662:veterinary; D006337:Heart Murmurs / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary*; D008944:Mitral Valve Insufficiency / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary*; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D015995:Prevalence