title: Fluorescent micelles based on star amphiphilic copolymer with a porphyrin core for bioimaging and drug delivery.
abstract: Star-shaped poly(ε-caprolactone)-b-poly(ethylene oxide) amphiphilic copolymer with a tetrakis-(4-aminophenyl)-terminated porphyrin core was synthesized. Paclitaxel (PTX)-loaded polymeric micelles were prepared by the self-assembly of the star copolymer and in situ encapsulation of PTX. The fluorescent characteristic of the porphyrin moiety allowed the cellular uptake and biodistribution of the PTX-loaded micelles to be monitored by fluorescent imaging. The PTX-loaded micelles can be readily internalized by cancer cells and have a slightly higher cytotoxicity than clinic PTX injection Taxol. In vivo real-time fluorescent imaging revealed that the micelles could accumulate at tumor site via the blood circulation in tumor-bearing mice. In vivo antitumor efficacy examinations indicated that the PTX-loaded micelles had significantly superior efficacy in impeding tumor growth than Taxol and low toxicity to the living mice.
authors: Laboratory of Mesoscopic Chemistry and Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing, P. R. China.
authors: Luzhong
authors: L
authors: Zhang
authors: Ying
authors: Y
authors: Lin
authors: Yajun
authors: Y
authors: Zhang
authors: Rui
authors: R
authors: Chen
authors: Zhenshu
authors: Z
authors: Zhu
authors: Wei
authors: W
authors: Wu
authors: Xiqun
authors: X
authors: Jiang
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry; D051379:Mice; D008823:Micelles; D008856:Microscopy, Fluorescence / Q000379:methods; D008968:Molecular Conformation; D017239:Paclitaxel / Q000008:administration & dosage* / Q000493:pharmacokinetics; D010316:Particle Size; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011166:Porphyrins / Q000737:chemistry; D014018:Tissue Distribution; D014183:Transplantation, Heterologous; D047368:Tumor Burden / Q000187:drug effects
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D007783:Lactones; D008823:Micelles; D011108:Polymers; D011166:Porphyrins; C473831:poly(ethylene oxide)-b-poly(caprolactone); D011092:Polyethylene Glycols; D017239:Paclitaxel