title: Rapid injection of propofol reduces vascular pain and facilitates Laryngeal Mask Airway insertion.
abstract: OBJECTIVE
  To compare the clinical efficacy of a rapid injection of propofol in regard to pain and ability to facilitate Laryngeal Mask Airway (LMA) insertion.
  
  
  METHODS
  Randomized, single-blinded, placebo-controlled study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  120 ASA physical status 1 and 2 patients undergoing elective orthopedic surgeries.
  
  
  METHODS
  Patients were randomly allocated to one of 4 groups. Group A patients were pretreated with normal saline followed by propofol 2.0 mg/kg at 3.3 mg/sec. Group B patients were pretreated with lidocaine 0.5 mg/kg followed by propofol 2.0 mg/kg at 3.3 mg/sec. In Group C, patients were pretreated with lidocaine 1.0 mg/kg followed by propofol 2.0 mg/kg at 3.3 mg/sec. In Group D, patients were pretreated with normal saline followed by propofol 2.0 mg/kg at 50 mg/sec.
  
  
  METHODS
  Pain on injection was measured using a 4-point scale. Scale and success rate of smooth LMA insertion also were recorded.
  
  
  RESULTS
  Rapid injection was less painful than after pretreatment with lidocaine 0.5 mg/kg, but was similar to slow injection after pretreatment with lidocaine 1.0 mg/kg. Rapid injection facilitated LMA insertion, unlike slow injection with lidocaine 0.5 mg/kg pretreatment, and was similarly successful to slow injection after pretreatment with lidocaine 1.0 mg/kg.
  
  
  CONCLUSIONS
  The rapid administration of propofol reduces pain and facilitates LMA insertion versus slow administration of propofol.
authors: Department of Anesthesiology and Critical Care Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan. takerushimizu@yahoo.co.jp
authors: Takeru
authors: T
authors: Shimizu
authors: Shinichi
authors: S
authors: Inomata
authors: Makoto
authors: M
authors: Tanaka
mesh_terms: D000328:Adult; D000368:Aged; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000009:adverse effects; D000779:Anesthetics, Local / Q000627:therapeutic use; D005260:Female; D006785:Hospitals, University; D006801:Humans; D017214:Laryngeal Masks; D008012:Lidocaine / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D015742:Propofol / Q000008:administration & dosage* / Q000009:adverse effects; D011446:Prospective Studies; D016037:Single-Blind Method; D055815:Young Adult
chemical_list: D018686:Anesthetics, Intravenous; D000779:Anesthetics, Local; D008012:Lidocaine; D015742:Propofol