title: Low-magnitude high-frequency loading via whole body vibration enhances bone-implant osseointegration in ovariectomized rats.
abstract: Osseointegration is vital to avoid long-time implants loosening after implantation surgery. This study investigated the effect of low-magnitude high-frequency (LMHF) loading via whole body vibration on bone-implant osseointegration in osteoporotic rats, and a comparison was made between LMHF vibration and alendronate on their effects. Thirty rats were ovariectomized to induce osteoporosis, and then treated with LMHF vibration (VIB) or alendronate (ALN) or a control treatment (OVX). Another 10 rats underwent sham operation to establish Sham control group. Prior to treatment, hydroxyapatite (HA)-coated titanium implants were inserted into proximal tibiae bilaterally. Both LMHF vibration and alendronate treatment lasted for 8 weeks. Histomorphometrical assess showed that both group VIB, ALN and Sham significantly increased bone-to-implant contact and peri-implant bone fraction (p < 0.05) when compared with group OVX. Nevertheless the bone-to-implant contact and peri-implant bone fraction of group VIB were inferior to group ALN and Sham (p < 0.05). Biomechanical tests also revealed similar results in maximum push out force and interfacial shear strength. Accordingly, it is concluded that LMHF loading via whole body vibration enhances bone-to-implant osseointegration in ovariectomized rats, but its effectiveness is weaker than alendronate.
authors: Department of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. berlinch2007@yahoo.com.cn
authors: BaiLing
authors: B
authors: Chen
authors: YiQiang
authors: Y
authors: Li
authors: DengHui
authors: D
authors: Xie
authors: XiaoXi
authors: X
authors: Yang
mesh_terms: D019386:Alendronate / Q000627:therapeutic use; D000818:Animals; D001696:Biomechanical Phenomena; D001835:Body Weight; D015519:Bone Density; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D005260:Female; D020007:Implants, Experimental; D016348:Osseointegration / Q000187:drug effects; D010024:Osteoporosis / Q000188:drug therapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D014732:Vibration / Q000627:therapeutic use*
chemical_list: D050071:Bone Density Conservation Agents; D019386:Alendronate