title: Neuroprotection of paclitaxel against cerebral ischemia/reperfusion-induced brain injury through JNK3 signaling pathway.
abstract: In this study, we investigated the neuroprotective effects of paclitaxel in transient cerebral ischemia and possible regulatory mechanism of these neuroprotection. Our data showed that paclitaxel can down-regulate the increased MLK3, JNK3, c-Jun, Bcl-2, and caspase-3 phosphorylation induced by ischemia injury. Cresyl violet staining and immunohistochemistry results demonstrated that paclitaxel had neuroprotective effect against ischemia/reperfusion-induced neuronal cell death. These results indicated that paclitaxel has neuroprotection in ischemic injury through JNK3 signaling pathway and provided a novel possible drug in therapeutics of brain ischemia.
authors: Research Center for Biochemistry and Molecular Biology and Provincial Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical College , Xuzhou, P. R. China. qisuhua9999@163.com
authors: Su-Hua
authors: SH
authors: Qi
authors: Hui
authors: H
authors: Zhao
authors: Juan-Juan
authors: JJ
authors: Gong
authors: Fu-Mou
authors: FM
authors: Sun
authors: Jun
authors: J
authors: Yue
authors: Qiu-Hua
authors: QH
authors: Guan
authors: Min
authors: M
authors: Wang
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002545:Brain Ischemia / Q000201:enzymology*; D053148:Caspase 3 / Q000378:metabolism; D016923:Cell Death; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism; D020930:MAP Kinase Kinase Kinases / Q000378:metabolism; D020935:MAP Kinase Signaling System / Q000187:drug effects; D008297:Male; D048057:Mitogen-Activated Protein Kinase 10 / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects / Q000201:enzymology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D017239:Paclitaxel / Q000494:pharmacology*; D010766:Phosphorylation / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000201:enzymology*; D050257:Tubulin Modulators / Q000494:pharmacology*; D000097767:Mitogen-Activated Protein Kinase Kinase Kinase 11
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D053148:Caspase 3; D048031:JNK Mitogen-Activated Protein Kinases; D020930:MAP Kinase Kinase Kinases; D048057:Mitogen-Activated Protein Kinase 10; D018696:Neuroprotective Agents; D017239:Paclitaxel; D050257:Tubulin Modulators; D000097767:Mitogen-Activated Protein Kinase Kinase Kinase 11