title: Relationship between plasma aldosterone concentration and soluble cellular adhesion molecules in patients referred to coronary angiography.
abstract: OBJECTIVE
  Evidence is emerging that aldosterone contributes to the development and progression of atherosclerosis and cardiovascular disease. Little is known, however, regarding an association between circulating aldosterone levels and soluble cellular adhesion molecules in humans.
  
  
  METHODS
  We investigated the relationship between plasma aldosterone concentration (PAC) and soluble cellular adhesion molecules in a large cohort of patients referred to coronary angiography. After exclusion of patients with ongoing mineralocorticoid receptor blocker use, oral contraceptive or hormone replacement therapy, 1,733 patients (mean age: 62.5±10.8 years; 26.4%% women; mean PAC: 101.5±93.5 pg/mL) remained eligible for analyses.
  
  
  RESULTS
  Pearson correlation analysis as well as age and gender adjusted partial correlation analysis revealed a positive association between PAC and soluble (s) E-, L- and P-selectin levels but not with sICAM-1 and sVCAM-1, respectively. In multivariate adjusted analyses of covariance (ANCOVA) sE- (p=0.026), sL- (p=0.049) and sP-selectin (p<0.001) levels increased steadily from the first (reference) to the third gender-specific tertile of PAC. No significant variation across PAC tertiles was found for sICAM-1 (p=0.767) and sVCAM1 (p=0.425) levels, respectively. Finally, multivariate regression analyses revealed circulating aldosterone as an important predictor for soluble selectin levels.
  
  
  CONCLUSIONS
  Our findings in a large cohort of patients indicate that upregulation of selectins might represent a novel mechanism of aldosterone mediated development and progression of atherosclerosis. In view of aldosterone as a novel cardiovascular risk factor independent of angiotensin II, our findings warrant further interventional studies which should evaluate anti-atherosclerotic effects of aldosterone blocking treatment strategies in humans.
authors: Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Graz, Austria. andreas.tomaschitz@gmx.at
authors: A
authors: A
authors: Tomaschitz
authors: S
authors: S
authors: Pilz
authors: E
authors: E
authors: Ritz
authors: T
authors: T
authors: Grammer
authors: K
authors: K
authors: Amrein
authors: S
authors: S
authors: Merger
authors: A
authors: A
authors: Meinitzer
authors: B R
authors: BR
authors: Winkelmann
authors: B O
authors: BO
authors: Boehm
authors: W
authors: W
authors: März
mesh_terms: D000368:Aged; D000450:Aldosterone / Q000097:blood*; D050197:Atherosclerosis / Q000097:blood* / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000503:physiopathology; D015331:Cohort Studies; D017023:Coronary Angiography; D019040:E-Selectin / Q000097:blood* / Q000737:chemistry; D005060:Europe / Q000453:epidemiology; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000503:physiopathology; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood / Q000737:chemistry; D019041:L-Selectin / Q000097:blood* / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D019007:P-Selectin / Q000097:blood* / Q000737:chemistry; D015995:Prevalence; D012307:Risk Factors; D012720:Severity of Illness Index; D012995:Solubility; D015854:Up-Regulation; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood / Q000737:chemistry
chemical_list: D019040:E-Selectin; D019007:P-Selectin; C546936:SELE protein, human; C546935:SELL protein, human; C546937:SELP protein, human; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1; D019041:L-Selectin; D000450:Aldosterone