title: Molecular profiling of common fragile sites in human fibroblasts.
abstract: Common fragile sites have been mapped primarily in lymphocytes, but recent analyses show that the setting of these sites relies on cell type-dependent replication programs. Using a new approach, we molecularly mapped common fragile sites in human fibroblasts and showed that commitment to fragility depends on similar replication features in fibroblasts and lymphocytes, although different loci are committed in each cell type. Notably, the common fragile sites that we identified overlapped heretofore unexplained deletion clusters observed in tumors.
authors: Institut Curie, Centre de Recherche, Paris, France.
authors: Benoî
authors: B
authors: Le Tallec
authors: Bernard
authors: B
authors: Dutrillaux
authors: Anne-Marie
authors: AM
authors: Lachages
authors: Gael Armel
authors: GA
authors: Millot
authors: Olivier
authors: O
authors: Brison
authors: Michelle
authors: M
authors: Debatisse
mesh_terms: D001482:Base Composition; D002460:Cell Line; D043283:Chromosome Fragile Sites; D002874:Chromosome Mapping; D004261:DNA Replication / Q000502:physiology; D005347:Fibroblasts / Q000473:pathology / Q000502:physiology*; D006801:Humans