title: The Neurospora crassa DCC-1 protein, a putative histidine kinase, is required for normal sexual and asexual development and carotenogenesis.
abstract: Two-component signaling pathways based on phosphoryl group transfer between histidine kinase and response regulator proteins regulate environmental responses in bacteria, archaea, plants, slime molds, and fungi. Here we characterize a mutant form of DCC-1, a putative histidine kinase encoded by the NCU00939 gene of the filamentous fungus Neurospora crassa. We show that this protein participates in the regulation of processes such as conidiation, perithecial development, and, to a certain degree, carotenogenesis. Furthermore, DCC-1 is suggested to exert its effect by promoting cyclic AMP production, thereby placing this protein within the context of a signaling pathway.
authors: Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México DF, México.
authors: Carlos
authors: C
authors: Barba-Ostria
authors: Fernando
authors: F
authors: Lledías
authors: Dimitris
authors: D
authors: Georgellis
mesh_terms: D002338:Carotenoids / Q000096:biosynthesis*; D002940:Circadian Rhythm; D000242:Cyclic AMP / Q000096:biosynthesis; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D055786:Gene Knockout Techniques; D000071677:Histidine Kinase; D009024:Morphogenesis; D009492:Neurospora crassa / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development; D010641:Phenotype; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D012100:Reproduction, Asexual; D015398:Signal Transduction; D013172:Spores, Fungal / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development
chemical_list: D005656:Fungal Proteins; D002338:Carotenoids; D000242:Cyclic AMP; D011494:Protein Kinases; D000071677:Histidine Kinase