title: Neonatal hypoxia-ischemia induces sex-related changes in rat brain mitochondria.
abstract: The effects of neonatal hypoxia-ischemia (HI) on energy metabolism in male and female rats were investigated, testing the hypothesis that HI-induced brain mitochondrial dysfunction could present in a dimorphic pattern. Impairment in electron transport chain complex activities at 2 and 18 h after HI was observed in cortex and hippocampus in rats of both sexes, with females presenting an overall activity higher than that of males. Females also showed loss of mitochondrial mass and membrane potential 18 h after HI, while males were only slightly affected. These findings suggest a dimorphism in mitochondrial dysfunction and provide information that may lead to new neuroprotection strategies.
authors: Programa de Pós-Graduação em Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, UFRGS, Brazil. simonenardin@yahoo.com.br
authors: Simone N
authors: SN
authors: Weis
authors: Leticia F
authors: LF
authors: Pettenuzzo
authors: Rachel
authors: R
authors: Krolow
authors: Lauren M
authors: LM
authors: Valentim
authors: Carina S
authors: CS
authors: Mota
authors: Carla
authors: C
authors: Dalmaz
authors: Angela T S
authors: AT
authors: Wyse
authors: Carlos Alexandre
authors: CA
authors: Netto
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002540:Cerebral Cortex / Q000473:pathology*; D004579:Electron Transport; D004734:Energy Metabolism; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D000860:Hypoxia / Q000473:pathology*; D007511:Ischemia / Q000473:pathology*; D008297:Male; D053078:Membrane Potential, Mitochondrial; D008928:Mitochondria / Q000502:physiology*; D051336:Mitochondrial Membranes / Q000502:physiology; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012737:Sex Factors