title: Nanoencapsulated anti-CK2 small molecule drug or siRNA specifically targets malignant cancer but not benign cells.
abstract: CK2, a pleiotropic Ser/Thr kinase, is an important target for cancer therapy. We tested our novel tenfibgen-based nanocapsule for delivery of the inhibitor 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole (DMAT) and an siRNA directed against both CK2α and α' catalytic subunits to prostate cancer cells. We present data on the TBG nanocapsule itself and on CK2 inhibition or downregulation in treated cells, including effects on Nuclear Factor-kappa B (NF-κB) p65. By direct comparison of two CK2-directed cargos, our data provide proof that the TBG encapsulation design for delivery of drugs specifically to cancer cells has strong potential for small molecule- and nucleic acid-based cancer therapy.
authors: Research Service, Minneapolis VA Health Care System, MN, USA.
authors: Janeen H
authors: JH
authors: Trembley
authors: Gretchen M
authors: GM
authors: Unger
authors: Vicci L
authors: VL
authors: Korman
authors: Diane K
authors: DK
authors: Tobolt
authors: Zygmunt
authors: Z
authors: Kazimierczuk
authors: Lorenzo A
authors: LA
authors: Pinna
authors: Betsy T
authors: BT
authors: Kren
authors: Khalil
authors: K
authors: Ahmed
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D047390:Casein Kinase II / Q000037:antagonists & inhibitors* / Q000235:genetics* / Q000378:metabolism; D048708:Cell Growth Processes / Q000187:drug effects / Q000235:genetics; D045744:Cell Line, Tumor; D015536:Down-Regulation; D006801:Humans; D008297:Male; D051379:Mice; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics / Q000628:therapy*; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000235:genetics* / Q000493:pharmacokinetics; D014162:Transfection
chemical_list: C492322:2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole; D001562:Benzimidazoles; D034741:RNA, Small Interfering; D047390:Casein Kinase II