title: Study on the usefulness of high-molecular-weight (HMW)-Adiponectin level check of Japanese general population upon health check: comparison of carotid ultrasonography measurement.
abstract: OBJECTIVE
  High-molecular-weight (HMW)-adiponectin is an active and powerful predictor of atherosclerosis. Unfortunately, there is currently no reliable epidemiological reference level data available in Japan. The current ELISA method for HMW-adiponectin measurement is tedious as it requires several sample pre-treatment steps. We studied the reference level of HMW-adiponectin measured by a simple, fully-automated CLEIA.
  
  
  METHODS
  The study subjects were 858 men and 793 women who underwent health check-ups at a Japanese Red Cross Medical Center. We investigated the relation between HMW-adiponectin and metabolic parameters, including carotid ultrasonography.
  
  
  RESULTS
  The mean values of HMW-adiponectin were 3.11 ± 1.99 μg/ml in men, and 5.52 ± 3.07 μg/ml in women. There were significant differences (p<0.001) in relation to gender and age, where levels gradually increased with age. HMW-adiponectin was 3.18 ± 1.45 μg/ml in male subjects without carotid lesions, and 2.28 ± 0.90 μg/ml in male subjects with lesions.
  
  
  CONCLUSIONS
  HMW-adiponectin measured by simple CLEIA could be useful for routine risk assessment.
authors: Department of Health Care, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo 150-8935, Japan. komatsu_junko@med.jrc
authors: Junko
authors: J
authors: Komatsu
authors: Mutsunori
authors: M
authors: Fujiwara
authors: Masaaki
authors: M
authors: Matsuura
authors: Satoru
authors: S
authors: Ito
authors: Masae
authors: M
authors: Oritsu
mesh_terms: D050153:Abdominal Fat / Q000473:pathology; D052242:Adiponectin / Q000097:blood*; D000367:Age Factors; D000368:Aged; D050197:Atherosclerosis / Q000175:diagnosis; D001331:Automation; D002339:Carotid Arteries / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D012016:Reference Values; D012044:Regression Analysis; D018570:Risk Assessment; D012737:Sex Factors; D014463:Ultrasonography / Q000379:methods*
chemical_list: D052242:Adiponectin