title: Stopping the control arm in response to the DSMB: mother's choice of HIV prophylaxis during breastfeeding in the BAN Study.
abstract: The Data and Safety Monitoring Board (DSMB) for the Breastfeeding, Antiretrovirals, and Nutrition study, a clinical trial aimed to prevent postnatal HIV transmission, recommended halting randomization to the enhanced standard-of-care (control) arm. The 67 mother-infant pairs on the control arm and less than 21 weeks postpartum at the time of the DSMB recommendation were read a script informing them of the DSMB decision and offering them the maternal or infant antiretroviral interventions for the remainder of the 28-week breastfeeding period. This paper describes the BAN study response to the DSMB decision and what the women on the control arm chose, when given a choice to start the maternal or infant antiretroviral interventions.
authors: UNC Project, Lilongwe, Malawi. cchavula@unclilongwe.org
authors: Charity
authors: C
authors: Chavula
authors: Dustin
authors: D
authors: Long
authors: Enalla
authors: E
authors: Mzembe
authors: Dumbani
authors: D
authors: Kayira
authors: Charles
authors: C
authors: Chasela
authors: Michael G
authors: MG
authors: Hudgens
authors: Mina
authors: M
authors: Hosseinipour
authors: Caroline C
authors: CC
authors: King
authors: Sascha
authors: S
authors: Ellington
authors: Margret
authors: M
authors: Chigwenembe
authors: Denise J
authors: DJ
authors: Jamieson
authors: Charles
authors: C
authors: van der Horst
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D001942:Breast Feeding; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000517:prevention & control* / Q000635:transmission; D015497:HIV-1; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D008895:Milk, Human / Q000821:virology*; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents