title: [Research progress in relations between renin angiotensin system and diabetic cardiomyopathy].
abstract: Renin-angiotensin system (RAS) is activated in diabetes. The rise of angiotension II (Ang II) stimulates the cardiac fibroblast proliferation and the alteration of collagen metabolism through AT1 receptor on cell surface, causing the myocardium interstitial and perivascular fibrosis, and the ventricular myocardium rigidity and diastolic function disturbance, leading to the clinical symptoms of diabetic cardiomyopathy (DCM). The main members of RAS including Ang II, Ang-(1-7), Ac-SDKP and ATR play the important role in the development of DCM. This article reviewed the interactions between RAS and endothelin (ET), reactive oxygen species (ROS), transforming growth factor-beta 1 (TGF-beta 1), nuclear factor-kappa b (NF-kappaB), signal transduction system and apoptosis in DCM.
authors: Institute of Materia Medica, Shandong Academy of Medical Sciences, Key Laboratory for Rare Disease of Shandong Province, Jinan 250062, China.
authors: Yi-chi
authors: YC
authors: Zhang
authors: Yan-ling
authors: YL
authors: Mou
authors: Yan-ying
authors: YY
authors: Xie
mesh_terms: D000803:Angiotensin I / Q000502:physiology; D000804:Angiotensin II / Q000097:blood / Q000502:physiology*; D000818:Animals; D017209:Apoptosis; D058065:Diabetic Cardiomyopathies / Q000503:physiopathology*; D006801:Humans; D016328:NF-kappa B / Q000378:metabolism; D009842:Oligopeptides / Q000502:physiology; D010446:Peptide Fragments / Q000502:physiology; D044140:Receptor, Angiotensin, Type 1 / Q000502:physiology; D012084:Renin-Angiotensin System / Q000502:physiology*; D015398:Signal Transduction; D053773:Transforming Growth Factor beta1 / Q000378:metabolism
chemical_list: D016328:NF-kappa B; D009842:Oligopeptides; D010446:Peptide Fragments; D044140:Receptor, Angiotensin, Type 1; D053773:Transforming Growth Factor beta1; D000804:Angiotensin II; D000803:Angiotensin I; C058504:goralatide; C118790:angiotensin I (1-7)