title: Circulating anti-Mullerian hormone levels in adult men are under a strong genetic influence.
abstract: BACKGROUND
  The determinants of serum anti-Müllerian hormone (AMH) levels in adult men remain unclear.
  
  
  OBJECTIVE
  The objective of the study was to investigate the genetic and environmental components in determining postpubertal AMH levels in healthy men.
  
  
  METHODS
  Serum AMH levels, body mass index (BMI), and fat mass (dual energy x-ray absorptiometry) were measured in 64 healthy male (23 monozygotic and 41 dizygotic) twin pairs.
  
  
  RESULTS
  Postpubertal AMH levels were highly genetically determined (broad sense heritability 0.92, 95% confidence interval 0.83-0.96). AMH correlated negatively with BMI (r = -0.26, P = 0.030) and fat mass (r = -0.23, P = 0.048). As AMH, BMI had a high heritability (0.68, 95% confidence interval 0.39-0.83), but no genetic correlation was observed between them.
  
  
  CONCLUSIONS
  AMH levels in men after puberty are under a strong genetic influence. Twin modeling suggests that AMH and BMI are influenced by different sets of genes.
authors: Obesity Research Unit, Helsinki University Central Hospital, FI-00029 Helsinki, Finland.
authors: Kirsi H
authors: KH
authors: Pietiläinen
authors: Jaakko
authors: J
authors: Kaprio
authors: Kirsi
authors: K
authors: Vaaralahti
authors: Aila
authors: A
authors: Rissanen
authors: Taneli
authors: T
authors: Raivio
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood* / Q000235:genetics; D001823:Body Composition; D015992:Body Mass Index; D004777:Environment; D059647:Gene-Environment Interaction; D005796:Genes / Q000502:physiology*; D006801:Humans; D008297:Male; D009765:Obesity / Q000097:blood / Q000235:genetics; D050177:Overweight / Q000097:blood / Q000235:genetics; D011627:Puberty / Q000097:blood / Q000378:metabolism / Q000502:physiology; D014427:Twins; D055815:Young Adult
chemical_list: D054304:Anti-Mullerian Hormone