title: Resuscitative effect of hyperoxia fluid on high-altitude hemorrhagic shock in rats and antishock mechanisms.
abstract: Pathophysiological characteristics of hemorrhagic shock at high altitude are different from that at plain which involve severe injury, high mortality, difficult treatment and compromised liquid tolerance. High-altitude pulmonary/cerebral edema and multiple-organ dysfunction render the conventional treatment ineffective. Herein, we evaluated the resuscitation effects of hyperoxia solution on high-altitude hemorrhagic shock in rats. For this purpose, a rat model of high-altitude (3,658 m) hemorrhagic shock was established on the plateau and hyperoxia solution (4 ml/kg) was infused through external jugular vein for resuscitation at 60 min post-hemorrhage. Blood pressure, blood gas, left and right ventricular pressure, lung and brain water content, survival time, survival rate at 2 h, levels of inflammatory cytokines and free oxygen radicals in blood and tissue were determined. After resuscitation with hyperoxia solution, blood pressure, arterial oxygen partial pressure, left and right ventricular systolic pressure, ±dp/dt max, survival time and rate were significantly increased. Lung and brain water content were unchanged, malondialdehyde activity in lung, brain and plasma and levels of TNF-α, IL-1, IL-6, and endothelin were significantly decreased. Besides, CGRP was elevated with reduced injury and improved lung and kidney functions. Concludingly, resuscitation with hyperoxia solution is feasible and more effective than other classical liquids, making it the first choice of treatment for high-altitude hemorrhagic shock.
authors: Department of High Altitude Diseases, College of High Altitude Military Medicine, 3rd Military Medical University, Chongqing 400038, China. zhouqq9918@yahoo.com.cn
authors: Qiquan
authors: Q
authors: Zhou
authors: Yongjun
authors: Y
authors: Luo
authors: Fuyu
authors: F
authors: Liu
authors: Yuqi
authors: Y
authors: Gao
authors: Yi
authors: Y
authors: He
authors: Bihai
authors: B
authors: Zheng
authors: Dingzhou
authors: D
authors: Yang
authors: Suzhi
authors: S
authors: Li
authors: Liangming
authors: L
authors: Liu
mesh_terms: D000531:Altitude; D000818:Animals; D001794:Blood Pressure; D004195:Disease Models, Animal; D016232:Endothelins / Q000032:analysis / Q000097:blood; D005440:Fluid Therapy; D006352:Heart Ventricles / Q000503:physiopathology; D007375:Interleukin-1 / Q000032:analysis / Q000097:blood; D015850:Interleukin-6 / Q000032:analysis / Q000097:blood; D007668:Kidney / Q000378:metabolism / Q000502:physiology; D008168:Lung / Q000378:metabolism / Q000502:physiology; D008297:Male; D008315:Malondialdehyde / Q000032:analysis / Q000097:blood; D009569:Nitric Oxide / Q000097:blood; D010100:Oxygen / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012151:Resuscitation; D012771:Shock, Hemorrhagic / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D013482:Superoxide Dismutase / Q000097:blood; D015996:Survival Rate; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000097:blood
chemical_list: D016232:Endothelins; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D010100:Oxygen