title: [The clinical and pathologic features of vascular amyloid deposits of amyloid nephropathy in 6 patients].
abstract: OBJECTIVE
  To analyze clinical and pathologic features of a rare vascular amyloid deposits of amyloid nephropathy (VADAN) in 6 patients, so as to improve its diagnosis and treatment.
  
  
  METHODS
  All patients received immunopathology, microscopy and electron microscopy examination, and amyloid types were analyzed.
  
  
  RESULTS
  There were 3 males and 3 females with ages ranging from 52 to 73 years. Two patients suffered from multiple myeloma. Majority patients had slight albuminuria and hematuria. One patient combined with minimal change glomerular disease presented nephrotic syndrome. One patient combined with IgA nephropathy had albuminuria and hematuria. And one patient had myeloma cast nephropathy with acute renal failure. Kidney biopsy proved amyloid deposits along interlobular arterial wall only in all 6 patients. Two cases secondary from multiple myeloma were κ amyloid, and the rests were λ amyloid.
  
  
  CONCLUSIONS
  VADAN is a rare type of amyloid nephropathy. Its clinical manifestation is different from common amyloid nephropathy. Kidney biopsy will benefit its differential diagnosis.
authors: Center of Nephrology, China-Japan Friendship Hospital, Beijing 100029, China. cliffzou@vip.sina.com
authors: Gu-ming
authors: GM
authors: Zou
authors: Bao
authors: B
authors: Dong
authors: Wen-ge
authors: WG
authors: Li
mesh_terms: D000368:Aged; D000686:Amyloidosis / Q000150:complications / Q000473:pathology*; D005260:Female; D005922:Glomerulonephritis, IGA / Q000209:etiology / Q000473:pathology; D006417:Hematuria / Q000209:etiology / Q000473:pathology; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000209:etiology / Q000473:pathology; D011507:Proteinuria / Q000209:etiology / Q000473:pathology