title: Synthesis and antihepatotoxic activity of 5-(2,3-dihydro-1,4-benzodioxane-6-yl)-3-substituted-phenyl-4,5-dihydro-1H-pyrazole derivatives.
abstract: In continuance of our search for newer antihepatotoxic agents some novel pyrazoline derivatives containing 1,4-dioxane ring system were synthesized starting from 3-(2,3-dihydro-1,4-benzodioxane-6-yl)-1-substituted-phenylprop-2-en-1-one. Some of the synthesized compounds were evaluated for antihepatotoxic activity against CCl(4)-induced hepatotoxicity in rats. Among them some compounds have shown significant antihepatotoxic activity comparable to standard drug silymarin.
authors: Department of Pharmaceutical Chemistry, Alwar Pharmacy College, Alwar 301030, Rajasthan, India. shabib79@yahoo.co.in
authors: Habibullah
authors: H
authors: Khalilullah
authors: Shamshir
authors: S
authors: Khan
authors: Mohamed Jawed
authors: MJ
authors: Ahsan
authors: Bahar
authors: B
authors: Ahmed
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D004146:Dioxanes / Q000737:chemistry*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D020011:Protective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004146:Dioxanes; D020011:Protective Agents; D011720:Pyrazoles; C031280:pyrazole; D002251:Carbon Tetrachloride; C527681:1,4-benzodioxan