title: Meta-analysis of an association of  codon 72 polymorphisms of the p53 gene with increased endometrial cancer risk.
abstract: Polymorphisms  of the p53 gene have been associated with susceptibility to endometrial cancer.  However, whether there is a specific association is still controversial. We  investigated a possible association between p53 codon 72 polymorphism and  endometrial cancer risk by conducting a meta-analysis. Publications addressing  this association were selected from the Pubmed, Embase and CBM databases (up to  January 2011). Data were extracted from the studies by two independent  reviewers. The meta-analysis was performed using RevMan 5.0.25 and STATA 9.2  softwares. The odds ratio (OR) with 95% confidence intervals (CI) was  calculated. Then, 10 case-control studies were retrieved, with a total of 917  endometrial cancer patients and 1680 healthy controls. Meta-analysis results  showed that the Pro allele and Pro carrier (Arg/Pro + Pro/Pro) of p53 codon 72  polymorphism were significantly related with endometrial cancer risk (OR =  1.25, 95%CI = 1.10-1.41, P = 0.0005; OR = 1.34, 95%CI = 1.12-1.59, P = 0.001,  respectively). In the subgroup analysis, based on ethnicity, studies were  divided into Asian and Caucasian populations; the Pro allele and Pro carrier  (Arg/Pro + Pro/Pro) of p53 codon 72 polymorphism were significantly related  with endometrial cancer risk in Asian populations (OR = 1.41, 95%CI =  1.19-1.66, P < 0.0001; OR = 1.66,  95%CI = 1.30-2.13, P < 0.0001,  respectively), but not in Caucasian populations (both P > 0.05). We  concluded that the Pro allele (Arg/Pro + Pro/Pro) of p53 codon 72 polymorphism  is a potential risk factor for endometrial cancer.
authors: Department of Obstetrics and Gynecology, The Shengjing Affiliated Hospital of China Medical University, Shenyang, China.
authors: Y
authors: Y
authors: Gu
authors: X
authors: X
authors: Zhou
authors: S L
authors: SL
authors: Zhang
mesh_terms: D003062:Codon / Q000235:genetics*; D016889:Endometrial Neoplasms / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016014:Linear Models; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
chemical_list: D003062:Codon; D016159:Tumor Suppressor Protein p53