title: Minimally invasive non-thermal laser technology using laser-induced optical breakdown for skin rejuvenation.
abstract: We describe a novel, minimally invasive laser technology for skin rejuvenation by creating isolated microscopic lesions within tissue below the epidermis using laser induced optical breakdown. Using an in-house built prototype device, tightly focused near-infrared laser pulses are used to create optical breakdown in the dermis while leaving the epidermis intact, resulting in lesions due to cavitation and plasma explosion. This stimulates a healing response and consequently skin remodelling, resulting in skin rejuvenation effects. Analysis of ex-vivo and in-vivo treated human skin samples successfully demonstrated the safety and effectiveness of the microscopic lesion creation inside the dermis. Treatments led to mild side effects that can be controlled by small optimizations of the optical skin contact and treatment depth within the skin. The histological results from a limited panel test performed on five test volunteers show evidence of microscopic lesion creation and new collagen formation at the sites of the optical breakdown. This potentially introduces a safe, breakthrough treatment procedure for skin rejuvenation without damaging the epidermis with no or little social down-time and with efficacy comparable to conventional fractional ablative techniques.
authors: Department of Dermatology, Medisch Centrum 't Gooi, Bussum, The Netherlands.
authors: Louis
authors: L
authors: Habbema
authors: Rieko
authors: R
authors: Verhagen
authors: Robbert
authors: R
authors: Van Hal
authors: Yan
authors: Y
authors: Liu
authors: Babu
authors: B
authors: Varghese
mesh_terms: D000328:Adult; D000368:Aged; D003880:Dermatology / Q000379:methods; D020405:Dermis / Q000473:pathology; D004817:Epidermis / Q000473:pathology*; D006801:Humans; D007834:Lasers; D008027:Light; D008875:Middle Aged; D055095:Optics and Photonics; D012060:Rejuvenation; D012867:Skin / Q000473:pathology*; D015595:Skin Aging / Q000528:radiation effects; D014945:Wound Healing