title: Co-occurrence of Chiari malformations and sickle cell disease-a diagnostic dilemma: a report of 4 cases and review of literature.
abstract: The co-occurrence of sickle cell disease (SCD) and Chiari malformation (CM) poses clinical and diagnostic challenge since symptoms of both conditions may overlap. Although SCD and CM do not have a causal relationship, the overlapping neurologic symptoms may pose a diagnostic dilemma. To the best of our knowledge, the clinical manifestations and long-term consequence of CM in children with SCD has hitherto not been reported in the literature. We describe clinical manifestations of co-occurrence of SCD and CM in a case series of 4 African American children.
authors: Department of Pediatric and Human Development, Michigan State University, East Lansing, MI, USA. s.chonat@yahoo.com
authors: Satheesh
authors: S
authors: Chonat
authors: Elna
authors: E
authors: Saah
authors: Renuka
authors: R
authors: Gera
authors: Ajovi
authors: A
authors: Scott-Emuakpor
authors: Roshni
authors: R
authors: Kulkarni
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000175:diagnosis*; D001139:Arnold-Chiari Malformation / Q000150:complications* / Q000175:diagnosis*; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male