title: [Secondary angiosarcomas after conservation treatment for breast cancers].
abstract: BACKGROUND
  The cancerogenic effect of ionizing radiation was documented just several years after it started to be used as a treatment option. Ionizing radiation produces a small but detectable risk of carcinoma as well as bone and soft tissue sarcomas. Over the past 20 years angiosarcomas arising from the area of the irradiated breast have been reported with increasing frequency as the number of women undergoing the breast conserving surgery with consecutive radiotherapy has increased also. Angiosarcomas can originate from either lymphatic or capillary endothelium, namely lymphangiosarcomas and haemangiosarcomas. The most of haemangiosarcomas arising from the breast skin developed in the irradiated area after breast conserving procedure--secondary angiosarcomas. Lymphangiosarcoma is typically associated with longstanding extremity lymphedema--Stewart-Treves syndrome.
  
  
  METHODS
  We report three cases of angiosarcomas which occured in this region after breast conserving treatment and we also review the literature.
  
  
  CONCLUSIONS
  Paradoxically, the decrease in the use of radiotherapy to the post-mastectomy chest wall and the axillary area is expected to reduce the incidence of angiosarcomas, while the increase in the use of breast conserving procedure plus radiotherapy could lead to increased incidence of angiosarcomas in the residual breast tissue. Special attention should be paid to skin leasions and changes occuring after breast conserving treatment and especially to the ones with the skinthickening. The early detection and diagnosis has the crucial prognostic value.
authors: Radioterapeutické a onkologické oddelení, FN Plzen. vojtisekr@fnplzen.cz
authors: R
authors: R
authors: Vojtísek
authors: Z
authors: Z
authors: Kinkor
authors: J
authors: J
authors: Fínek
mesh_terms: D000368:Aged; D001940:Breast; D001943:Breast Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D005260:Female; D006394:Hemangiosarcoma / Q000209:etiology*; D006801:Humans; D015412:Mastectomy, Segmental; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000209:etiology*; D012878:Skin Neoplasms / Q000209:etiology*