title: The inside out of lentiviral vectors.
abstract: Lentiviruses induce a wide variety of pathologies in different animal species. A common feature of the replicative cycle of these viruses is their ability to target non-dividing cells, a property that constitutes an extremely attractive asset in gene therapy. In this review, we shall describe the main basic aspects of the virology of lentiviruses that were exploited to obtain efficient gene transfer vectors. In addition, we shall discuss some of the hurdles that oppose the efficient genetic modification mediated by lentiviral vectors and the strategies that are being developed to circumvent them.
authors: Department of Human Virology, Ecole Normale Supérieure de Lyon, 46 Allée d'Italie, 69364 Lyon, France.|INSERM U758, 46 Allée d'Italie, 69364 Lyon, France.|University of Lyon 1, 50 Avenue Tony Garnier, 69364 Lyon, France.|IFR128 BioSciences Lyon-Gerland, Lyon-Biopole, 69364 Lyon, France.
authors: Stéphanie
authors: S
authors: Durand
authors: Department of Human Virology, Ecole Normale Supérieure de Lyon, 46 Allée d'Italie, 69364 Lyon, France.|INSERM U758, 46 Allée d'Italie, 69364 Lyon, France.|University of Lyon 1, 50 Avenue Tony Garnier, 69364 Lyon, France.|IFR128 BioSciences Lyon-Gerland, Lyon-Biopole, 69364 Lyon, France.
authors: Andrea
authors: A
authors: Cimarelli
mesh_terms: D000818:Animals; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D016086:Lentivirus / Q000235:genetics*; D022423:Myeloid Cells / Q000821:virology