title: Efficient synthesis of a novel m-phenylene derivative as a selective EP4 agonist inducing follicular growth and maturation in the ovary.
abstract: An efficient and straightforward synthesis of a novel m-phenylene derivative has been developed. The optically pure dibromo compound was selected as a starting material. Through a protocol involving the Prins reaction and two steps of the Horner-Wadsworth-Emmons reaction, the basic skeleton was constructed with appropriate alpha and omega side chains. The compound proved to be a highly selective EP(4) agonist and a possible drug candidate for maturation of the uterine cervix.
authors: Pharmaceutical Research Laboratories, Toray Industries, Inc., 6-10-1 Tebiro, Kamakura, Kanagawa 248-8555, Japan. Ryoji_Hayashi2@nts.toray.co.jp
authors: Ryoji
authors: R
authors: Hayashi
authors: Yutaka
authors: Y
authors: Hosono
authors: Koji
authors: K
authors: Nakatsuji
authors: Yoichiro
authors: Y
authors: Tanaka
authors: Takeshi
authors: T
authors: Mori
authors: Takami
authors: T
authors: Kanno
authors: Kei
authors: K
authors: Makita
authors: Mitsuhiro
authors: M
authors: Moriwaki
authors: Tomofumi
authors: T
authors: Ohyama
authors: Yasuo
authors: Y
authors: Ochi
authors: Chifumi
authors: C
authors: Inada
authors: Masafumi
authors: M
authors: Isogaya
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002584:Cervix Uteri / Q000254:growth & development; D005260:Female; D006168:Guinea Pigs; D006080:Ovarian Follicle / Q000187:drug effects* / Q000254:growth & development; D011817:Rabbits; D058309:Receptors, Prostaglandin E, EP4 Subtype / Q000819:agonists* / Q000378:metabolism
chemical_list: D001572:Benzofurans; D058309:Receptors, Prostaglandin E, EP4 Subtype