title: Reliability of a new biokinetic model of zirconium in internal dosimetry: part II, parameter sensitivity analysis.
abstract: The reliability of biokinetic models is essential for the assessment of internal doses and a radiation risk analysis for the public and occupational workers exposed to radionuclides. In the present study, a method for assessing the reliability of biokinetic models by means of uncertainty and sensitivity analysis was developed. In the first part of the paper, the parameter uncertainty was analyzed for two biokinetic models of zirconium (Zr); one was reported by the International Commission on Radiological Protection (ICRP), and one was developed at the Helmholtz Zentrum München-German Research Center for Environmental Health (HMGU). In the second part of the paper, the parameter uncertainties and distributions of the Zr biokinetic models evaluated in Part I are used as the model inputs for identifying the most influential parameters in the models. Furthermore, the most influential model parameter on the integral of the radioactivity of Zr over 50 y in source organs after ingestion was identified. The results of the systemic HMGU Zr model showed that over the first 10 d, the parameters of transfer rates between blood and other soft tissues have the largest influence on the content of Zr in the blood and the daily urinary excretion; however, after day 1,000, the transfer rate from bone to blood becomes dominant. For the retention in bone, the transfer rate from blood to bone surfaces has the most influence out to the endpoint of the simulation; the transfer rate from blood to the upper larger intestine contributes a lot in the later days; i.e., after day 300. The alimentary tract absorption factor (fA) influences mostly the integral of radioactivity of Zr in most source organs after ingestion.
authors: Research Unit Medical Radiation Physics and Diagnostics, Helmholtz Zentrum München-German Research Center for Environmental Health (GmbH), D-85764 Neuherberg, Germany. wli@helmholtz-muenchen.de
authors: Wei Bo
authors: WB
authors: Li
authors: Matthias
authors: M
authors: Greiter
authors: Uwe
authors: U
authors: Oeh
authors: Christoph
authors: C
authors: Hoeschen
mesh_terms: D004435:Eating; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D011834:Radiation Monitoring; D011835:Radiation Protection; D011868:Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D035501:Uncertainty; D015040:Zirconium / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D011868:Radioisotopes; D015040:Zirconium