title: Effective cytochrome P450 (CYP) inhibitor isolated from thyme (Thymus saturoides) purchased from a Japanese market.
abstract: A highly polymethylated flavone that effectively inhibited cytochrome P450s (CYPs) 1A2 and 3A4 (IC(50) = 2.41 and 1.71 µM) in vitro was isolated from thyme leaves (Thymus saturoides) purchased from a Japanese market. Its structure was spectroscopically identified as 4',5-dihydroxy-3',6,7,8-tetramethoxy flavone (8-methoxycirsilineol, 1). This is the first report describing a strong inhibitor of CYP1A2 and 3A4 isolated from Thymus saturoides.
authors: Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture, Tokyo, Japan.
authors: Zeineb
authors: Z
authors: Brahmi
authors: Hitomi
authors: H
authors: Niwa
authors: Mio
authors: M
authors: Yamasato
authors: Sakurako
authors: S
authors: Shigeto
authors: Yuna
authors: Y
authors: Kusakari
authors: Kouichi
authors: K
authors: Sugaya
authors: Jun-ichi
authors: J
authors: Onose
authors: Naoki
authors: N
authors: Abe
mesh_terms: D065609:Cytochrome P-450 CYP1A2 Inhibitors; D065692:Cytochrome P-450 CYP3A Inhibitors; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D047309:Flavones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D018515:Plant Leaves / Q000737:chemistry; D046930:Thymus Plant / Q000737:chemistry*
chemical_list: D065609:Cytochrome P-450 CYP1A2 Inhibitors; D065692:Cytochrome P-450 CYP3A Inhibitors; D004791:Enzyme Inhibitors; D047309:Flavones; C570738:4',5-dihydroxy-3',6,7,8-tetramethoxyflavone