title: Candida vaccines development from point view of US patent application.
abstract: Candidiasis is the fourth most common bloodstream infection in hospitalized patients in the United States. Moreover, the mortality rate from Candida infections remains high, even after treatment with antifungal therapy. Vaccination would be a promising strategy for prevention of invasive fungal infections. In order to examine the main trends in anticandidal vaccine patenting activity, we conducted an analysis for anticandidal vaccine patents. We find 190 issued patent and 940 patent application documents containing the keywords Candida and vaccine within claims in the USA. Candida vaccines development, as evidenced by the numbers of issued patents, has decreased since the year 2002. Furthermore, the number of patent applications in Candida vaccines may indicate the strength of engaged resources were also in the status of stagnation during 2005-2007 and even a decline in 2008. Academic and nonprofit research institutions not only account for a large share of Candida vaccines patents but also apply for patents continually. Based on this analysis, the strength of Candida vaccines resources seems to remain stagnant in recent years due to patent prosecution or technical barrier in the filed of Candida vaccines. Therefore, we consider that Candida vaccines technology to still be under development and the researchers are still looking for scientific breakthrough in the filed.
authors: Taipei Veterans General Hospital, Division of Experimental Surgery, Institute of Hospital and Health Care Administration National Yang-Ming University, Taipei, Taiwan. wangsj@vghtpe.gov.tw
authors: Shyh-Jen
authors: SJ
authors: Wang
mesh_terms: D035843:Biomedical Research; D002175:Candida / Q000276:immunology*; D058387:Candidemia / Q000517:prevention & control*; D002177:Candidiasis / Q000517:prevention & control*; D005657:Fungal Vaccines / Q000627:therapeutic use*; D006801:Humans; D010330:Patents as Topic / Q000331:legislation & jurisprudence* / Q000706:statistics & numerical data*; D014481:United States
chemical_list: D005657:Fungal Vaccines