title: Sex hormone-binding globulin and type 2 diabetes mellitus.
abstract: Sex hormone-binding globulin (SHBG) has emerged as one of the multiple genetic and environmental factors that potentially contribute to the pathophysiology of type 2 diabetes mellitus (T2DM). In addition to epidemiologic studies demonstrating a consistent relationship between decreased levels of serum SHBG and incident T2DM, recent genetic studies also reveal that transmission of specific polymorphisms in the SHBG gene influence the risk of T2DM. At the molecular level, the multiple interactions between SHBG and its receptors in various target tissues suggest physiologic roles for SHBG that are more complex than the simple transport of sex hormones in serum. Taken together, these data provide support for an expanded role of SHBG in the pathophysiology of insulin resistance and T2DM.
authors: Department of Pediatrics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.
authors: Trang N
authors: TN
authors: Le
authors: John E
authors: JE
authors: Nestler
authors: Jerome F
authors: JF
authors: Strauss
authors: Edmond P
authors: EP
authors: Wickham
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D007333:Insulin Resistance; D011110:Polymorphism, Genetic; D011956:Receptors, Cell Surface / Q000378:metabolism; D012738:Sex Hormone-Binding Globulin / Q000032:analysis / Q000737:chemistry / Q000235:genetics / Q000502:physiology*
chemical_list: D011956:Receptors, Cell Surface; D012738:Sex Hormone-Binding Globulin; C063572:sex hormone-binding globulin receptor