title: Collagen-based biological glue after Appleby operation for advanced gastric cancer.
abstract: Pancreatic fistula is a common complication of distal pancreatectomy; although various surgical procedures have been proposed, no clear advantage is evident for a single technique. We herein report the case of a 38-year-old patient affected by an advanced gastric carcinoma infiltrating the pancreas body, with extensive nodal metastases involving the celiac trunk, who underwent total gastrectomy with lymphadenectomy, distal pancreatectomy and resection en bloc of the celiac trunk (Appleby operation). At the end of the demolitive phase, the pancreatic stump and the aorta at the level of the celiac ligature were covered with a layer of Tachosil(®), a horse collagen sponge made with human coagulation factors (fibrinogen and thrombin). Presenting this case, we wish to highlight the possible sealing effect of this product and hypothesize a role in preventing pancreatic fistula and postoperative lymphorrhagia from extensive nodal dissection.
authors: Department of Medical and Surgical Sciences, Surgical Clinic, Brescia University, 25127 Brescia, Italy. baiocchi@med.unibs.it
authors: Gianluca
authors: G
authors: Baiocchi
authors: Nazario
authors: N
authors: Portolani
authors: Federico
authors: F
authors: Gheza
authors: Stefano M
authors: SM
authors: Giulini
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D000269:Adhesives / Q000737:chemistry* / Q000627:therapeutic use*; D000328:Adult; D000818:Animals; D003094:Collagen / Q000737:chemistry / Q000627:therapeutic use*; D005743:Gastrectomy; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D010185:Pancreatic Fistula / Q000517:prevention & control; D010190:Pancreatic Neoplasms / Q000556:secondary / Q000601:surgery; D011183:Postoperative Complications / Q000517:prevention & control*; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery*
chemical_list: D000269:Adhesives; D003094:Collagen