title: Amyloid peptides incorporating a core sequence from the amyloid beta peptide and gamma amino acids: relating bioactivity to self-assembly.
abstract: A series of heptapeptides comprising the core sequence Aβ(16-20), KLVFF, of the amyloid β peptide coupled with paired N-terminal γ-amino acids are investigated in terms of cytotoxicity reduction and binding to the full Aβ peptide, both pointing to inhibition of fibrillisation for selected compounds. This is related to the self-assembly capacity of the heptapeptides.
authors: Dept of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK.
authors: Valeria
authors: V
authors: Castelletto
authors: Ge
authors: G
authors: Cheng
authors: Ian W
authors: IW
authors: Hamley
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry*; D016229:Amyloid beta-Peptides / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D006801:Humans; D009474:Neurons / Q000166:cytology / Q000187:drug effects; D009842:Oligopeptides / Q000737:chemistry* / Q000494:pharmacology*; D010446:Peptide Fragments / Q000737:chemistry*; D055503:Protein Multimerization / Q000187:drug effects
chemical_list: D000596:Amino Acids; D016229:Amyloid beta-Peptides; D009842:Oligopeptides; D010446:Peptide Fragments; C529399:amyloid beta-protein (16-20)