title: Synthesis of 3-substituted 1,5-aldehyde esters via an organocatalytic highly enantioselective conjugate addition of new carbonylmethyl 2-pyridinylsulfone to enals.
abstract: A highly enantioselective organocatalytic protocol for conjugate addition of new nucleophilic carbonylmethyl 2-pyridinylsulfone to enals has been developed in good yields and with high enantioselectivities. The resulting Michael adducts are versatile building blocks for a variety of organic transformations.
authors: School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
authors: Jing
authors: J
authors: Deng
authors: Fei
authors: F
authors: Wang
authors: Wenzhong
authors: W
authors: Yan
authors: Jin
authors: J
authors: Zhu
authors: Hualiang
authors: H
authors: Jiang
authors: Wei
authors: W
authors: Wang
authors: Jian
authors: J
authors: Li
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D004952:Esters; D007659:Ketones / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity; D013450:Sulfones / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D004952:Esters; D007659:Ketones; D011725:Pyridines; D013450:Sulfones