title: The promoter variant -803 G>A in the RBP4 gene is not associated with BMI, metabolic parameters or blood pressure in Caucasian children.
abstract: OBJECTIVE
  Studies in adults identified the -803 G>A promoter polymorphism (rs3758539) in the RBP4 gene (RBP4) as a functional variant conferring an increased risk for obesity and type 2 diabetes.
  
  
  METHODS
  We genotyped this polymorphism in a cohort of 304 lean and 283 obese children to assess a potential association with early onset obesity and blood pressure and evaluated the effect of this SNP on metabolic parameters in a smaller subset.
  
  
  RESULTS
  The allele frequency of -803 G>A was similar in obese compared to lean subjects (0.159 vs. 0.191, P=0.318). We did not detect an association of the variant with adiposity parameters nor with parameters of glucose and lipid metabolism or blood pressure in quantitative analyses.
  
  
  CONCLUSIONS
  Our study revealed that the promoter polymorphism -803 G>A in RBP4 is not associated with BMI, metabolic parameters or blood pressure in Caucasian children.
authors: University Hospital for Children & Adolescents, University of Leipzig, Germany.
authors: D
authors: D
authors: Friebe
authors: P
authors: P
authors: Kovacs
authors: M
authors: M
authors: Neef
authors: S
authors: S
authors: Blüher
authors: D
authors: D
authors: Schleinitz
authors: W
authors: W
authors: Kiess
authors: A
authors: A
authors: Körner
mesh_terms: D000293:Adolescent; D019943:Amino Acid Substitution; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005858:Germany; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D007333:Insulin Resistance; D008297:Male; D009765:Obesity / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D050177:Overweight / Q000097:blood / Q000235:genetics / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D054839:Retinol-Binding Proteins, Plasma / Q000737:chemistry / Q000235:genetics*; D044465:White People
chemical_list: C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma