title: Hydrodynamic flow in a synaptic cleft during exocytosis.
abstract: It is shown that exocytosis in a chemical synapse may be accompanied by "microjet" formation due to the overpressure that exists in the vesicles. This mechanism may take place either at complete fusion of a vesicle with the presynaptic membrane or in the so-called kiss-and-run mode of neurotransmitter release. A simple hydrodynamic model of the viscous incompressible flow arising in the synaptic cleft is suggested. The occurrence of hydrodynamic flow (microjet) leads to more efficient transport of neurotransmitter than in the case of classical diffusive transport.
authors: Applied Physics Group, MAE Department, Princeton University, Princeton, NJ, USA. shneyder@princeton.edu
authors: M N
authors: MN
authors: Shneider
authors: R S
authors: RS
authors: Gimatdinov
authors: A I
authors: AI
authors: Skorinkin
authors: I V
authors: IV
authors: Kovyazina
authors: E E
authors: EE
authors: Nikolsky
mesh_terms: D004058:Diffusion; D005089:Exocytosis; D057446:Hydrodynamics; D008954:Models, Biological; D013569:Synapses / Q000378:metabolism*