title: Noxious mechanosensation - molecules and circuits.
abstract: Drugs that block mechanically-evoked pain would be useful for many common pain conditions, but appropriate drug development targets have yet to be defined. There is increasing evidence that both peripheral sensory neuron wiring patterns as well as the expression of transducing molecules are important for modality specific pain sensations. Progress in identifying the cell types, candidate transducing molecules and wiring patterns involved in mechanosensation has been dramatic over the past few years. Here we focus on potential mechano-transducing channels, and the relevant cell types and wiring patterns that provide clues for new analgesic drug development strategies.
authors: Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK. J.Wood@ucl.ac.uk
authors: John N
authors: JN
authors: Wood
authors: Niels
authors: N
authors: Eijkelkamp
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D055808:Drug Discovery; D005786:Gene Expression Regulation / Q000502:physiology; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D010146:Pain / Q000188:drug therapy* / Q000378:metabolism*; D011984:Sensory Receptor Cells / Q000502:physiology*
chemical_list: D000700:Analgesics