title: Cytotoxic xanthone-anthraquinone heterodimers from an unidentified fungus of the order Hypocreales (MSX 17022).
abstract: Two new xanthone-anthraquinone heterodimers, acremoxanthone C (5) and acremoxanthone D (2), have been isolated from an extract of an unidentified fungus of the order Hypocreales (MSX 17022) by bioactivity-directed fractionation as part of a search for anticancer leads from filamentous fungi. Two known related compounds, acremonidin A (4) and acremonidin C (3) were also isolated, as was a known benzophenone, moniliphenone (1). The structures of these isolates were determined via extensive use of spectroscopic and spectrometric tools in conjunction with comparisons to the literature. All compounds (1-5) were evaluated against a suite of biological assays, including those for cytotoxicity, inhibition of the 20S proteasome, mitochondrial transmembrane potential and nuclear factor-κB.
authors: Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC 27402, USA.
authors: Sloan
authors: S
authors: Ayers
authors: Tyler N
authors: TN
authors: Graf
authors: Audrey F
authors: AF
authors: Adcock
authors: David J
authors: DJ
authors: Kroll
authors: Qi
authors: Q
authors: Shen
authors: Steven M
authors: SM
authors: Swanson
authors: Susan
authors: S
authors: Matthew
authors: Esperanza J
authors: EJ
authors: Carcache de Blanco
authors: Mansukh C
authors: MC
authors: Wani
authors: Blaise A
authors: BA
authors: Darveaux
authors: Cedric J
authors: CJ
authors: Pearce
authors: Nicholas H
authors: NH
authors: Oberlies
mesh_terms: D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D006999:Hypocreales / Q000737:chemistry*; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D015394:Molecular Structure; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000378:metabolism; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000880:Anthraquinones; D000970:Antineoplastic Agents; D016328:NF-kappa B; D044004:Xanthones; D046988:Proteasome Endopeptidase Complex