title: Phenolic compounds from Allium schoenoprasum, Tragopogon pratensis and Rumex acetosa and their antiproliferative effects.
abstract: Experimental studies have shown that phenolic compounds have antiproliferative and tumour arresting effects. The aim of this original study was to investigate the content of phenolic compounds (PhC) in flowers of Allium schoenoprasum (chive), Tragopogon pratensis (meadow salsify) and Rumex acetosa (common sorrel) and their effect on proliferation of HaCaT cells. Antiproliferative effects were evaluated in vitro using the following concentrations of phenolic compounds in cultivation medium: 100, 75, 50 and 25 µg/mL. Phenolic composition was also determined by HPLC. The results indicate that even low concentrations of these flowers' phenolic compounds inhibited cell proliferation significantly and the possible use of the studied herb's flowers as sources of active phenolic compounds for human nutrition.
authors: Polymer Centre, Faculty of Technology, Tomas Bata University at Zlin, 76272 Zlin, Czech Republic.
authors: Zdenka
authors: Z
authors: Kucekova
authors: Jiri
authors: J
authors: Mlcek
authors: Petr
authors: P
authors: Humpolicek
authors: Otakar
authors: O
authors: Rop
authors: Pavel
authors: P
authors: Valasek
authors: Petr
authors: P
authors: Saha
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor / Q000187:drug effects*; D027782:Chive / Q000033:anatomy & histology / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D035264:Flowers / Q000737:chemistry; D006801:Humans; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D031804:Rumex / Q000033:anatomy & histology / Q000737:chemistry*; D031188:Tragopogon / Q000033:anatomy & histology / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D010636:Phenols; D010936:Plant Extracts