title: Predictive value of different HDL particles for the protection against or risk of coronary heart disease.
abstract: The inverse relationship between plasma HDL levels and the risk of developing coronary heart disease is well established. The underlying mechanisms of this relationship are poorly understood, largely because HDL consist of several functionally distinct subpopulations of particles that are continuously being interconverted from one to another. This review commences with an outline of what is known about the origins of individual HDL subpopulations, how their distribution is regulated, and describes strategies that are currently available for isolating them. We then summarise what is known about the functionality of specific HDL subpopulations, and how these findings might impact on cardiovascular risk. The final section highlights major gaps in existing knowledge of HDL functionality, and suggests how these deficiencies might be addressed. This article is part of a Special Issue entitled Advances in High Density Lipoprotein Formation and Metabolism: A Tribute to John F. Oram (1945-2010).
authors: Lipid Research Group, The Heart Research Institute, Sydney, NSW, Australia. ryek@hri.org.au
authors: Kerry-Anne
authors: KA
authors: Rye
authors: Philip J
authors: PJ
authors: Barter
mesh_terms: D000818:Animals; D001053:Apolipoproteins / Q000378:metabolism; D003327:Coronary Disease / Q000097:blood*; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood* / Q000378:metabolism / Q000502:physiology; D010316:Particle Size; D012307:Risk Factors; D013046:Specific Gravity; D013499:Surface Properties
chemical_list: D001053:Apolipoproteins; D008075:Lipoproteins, HDL