title: Carbamazepine potentiates morphine analgesia on postoperative pain in morphine-dependent rats.
abstract: Postoperative pain and its control remain one of the most important issues in the field of surgery and health care systems. Morphine is a potent and effective analgesic, but substance abuse patients can manifest cross-tolerance to it, making it difficult to satisfy their analgesic/anesthetic requirements. As carbamazepine has shown antinociceptive properties in a variety of experimental and clinical settings, in the present study, we evaluated its potential antiallodynic effects on postoperative pain in naïve and morphine-dependent rats. Male rats were assigned to morphine-dependent and naïve groups and received intraperitoneally drug vehicles as control group, 3mg/kg morphine, 5, 10 or 15 mg/kg carbamazepine or 5mg/kg carbamazepine plus 3mg/kg morphine as a combination therapy 2 and 24h after surgery. Morphine-dependency was induced with multiple doses of morphine administered i.p. and plantar incision was made on the hind paw to simulate the postoperative pain. Paw withdrawal threshold (PWT) was obtained by von Frey filaments every 30 min after drug injection for up to 180 min. Morphine at 3mg/kg exerted antiallodynic effects in naïve rats and a decreased antinociception was observed in morphine-dependent rats. In contrast, 5mg/kg carbamazepine did not significantly alter PWT in naives but it was effective in dependent rats. 10 and 15 mg/kg carbamazepine attenuated allodynia following surgery in both groups. Co-administration of 5mg/kg carbamazepine with 3mg/kg morphine produced higher analgesia in morphine-dependent incised rats and prolonged antinociception as compared to morphine alone (P<0.05). Thus carbamazepine may potentiate the analgesic effect of chronically administered morphine on postoperative pain model in morphine-dependent rats.
authors: Neuroscience Research Center and Department of Pharmacology, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran. Naseri5674@yahoo.com
authors: Kobra
authors: K
authors: Naseri
authors: Masoumeh
authors: M
authors: Sabetkasaei
authors: Taraneh
authors: T
authors: Moini Zanjani
authors: Elham
authors: E
authors: Saghaei
mesh_terms: D000700:Analgesics / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001259:Ataxia / Q000139:chemically induced; D002220:Carbamazepine / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D004357:Drug Synergism; D006930:Hyperalgesia / Q000188:drug therapy; D006993:Hypnotics and Sedatives / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D009020:Morphine / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D009021:Morphine Dependence / Q000150:complications*; D017288:Pain Threshold / Q000187:drug effects; D010149:Postoperative Pain / Q000150:complications* / Q000188:drug therapy* / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000700:Analgesics; D006993:Hypnotics and Sedatives; D002220:Carbamazepine; D009020:Morphine