title: One-pot synthesis of hybrid multifunctional silica nanoparticles with tunable coating by click chemistry in reverse w/o microemulsion.
abstract: Multifunctional hybrid silica nanoparticles with a fluorescent core and tunable organic or polymeric shell can easily be prepared by a sol-gel process followed by 1,3 dipolar cycloaddition (CuAAC) in the same reverse quaternary W/O microemulsion. Compared to a classical multistep process, this one-pot synthesis reduces greatly the number of purification steps and avoids aggregation phenomena. The confinement of reactants inside the micellar system gives rise to a noticeable increase of the CuAAC reaction rate. In addition, using simultaneously two different substrates for CuAAC on silica allows us to obtain directly multifunctional hybrid nanoparticles displaying a double grafting without any separation or purification steps except the final recovery by centrifugation, which opens the door to a tunable coating of the nanoparticles. Particularly, the hydrophilic-lipophilic balance of the coating can be adjusted by implementing the pertinent MPEG:dodecyl azide ratio. As an application, the great versatility of this strategy has been proved by the one-pot synthesis of fluorescent silica nanoparticles with a PEG coating and encapsulating silver clusters.
authors: Ingénierie des Matériaux Polymères, Université Claude Bernard Lyon 1, UMR CNRS 5223, 15 Bd Latarjet, 69622 Villeurbanne Cedex, France.
authors: Cédric
authors: C
authors: Tissandier
authors: Noël
authors: N
authors: Diop
authors: Matteo
authors: M
authors: Martini
authors: Stéphane
authors: S
authors: Roux
authors: Olivier
authors: O
authors: Tillement
authors: Thierry
authors: T
authors: Hamaide