title: Maternal serum interleukin-6 levels predict impending funisitis in preterm premature rupture of membranes after completion of antibiotics.
abstract: OBJECTIVE
  To determine if maternal serum interleukin-6 (IL-6) levels remain predictive of funisitis after completion of antibiotic administration in preterm premature rupture of membranes (PPROM).
  
  
  METHODS
  A secondary analysis of a prospective cohort study. Daily blood samples obtained from PPROM subjects were analyzed for IL-6 by enzyme-linked immunosorbent assay. Subjects (N = 39) delivered >7 days post admission and were divided into those with and without funisitis. Data were analyzed using Mann-Whitney U test.
  
  
  RESULTS
  Maternal serum IL-6 levels obtained 24-48 hours and 48-72 hours before delivery are elevated in PPROM subjects with funisitis compared to those without funisitis (6.3 vs. 2.7 pg/ml, P < 0.03; 6.1 vs. 1.7 pg/ml, P < 0.02). Receiver operator characteristic curve revealed an IL-6 level of 1.98 pg/ml had sensitivity of 86.7%, specificity of 46.7%, positive predictive value of 61.9% and negative predictive value of 77.8%.
  
  
  CONCLUSIONS
  This data suggests that maternal serum IL-6 levels continue to be predictive of PPROM subjects destined to develop funisitis after completion of antibiotics.
authors: Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Duke University Medical Center, Durham, NC 27710, USA. bcanzoneri@ochsner.org
authors: Bernard J
authors: BJ
authors: Canzoneri
authors: Chad A
authors: CA
authors: Grotegut
authors: Geeta K
authors: GK
authors: Swamy
authors: Leo R
authors: LR
authors: Brancazio
authors: Tammy
authors: T
authors: Sinclair
authors: Phillips R
authors: PR
authors: Heine
authors: Amy P
authors: AP
authors: Murtha
mesh_terms: D000667:Ampicillin / Q000008:administration & dosage / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D017963:Azithromycin / Q000008:administration & dosage / Q000627:therapeutic use; D002821:Chorioamnionitis / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy*; D036861:Delivery, Obstetric / Q000706:statistics & numerical data; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D009035:Mothers; D011247:Pregnancy / Q000097:blood; D011379:Prognosis; D013997:Time Factors; D017211:Treatment Failure
chemical_list: D000900:Anti-Bacterial Agents; D015850:Interleukin-6; D000667:Ampicillin; D017963:Azithromycin