title: Hürthle cell carcinoma of the thyroid presenting as thyrotoxicosis.
abstract: OBJECTIVE
  To report a case of hyperthyroidism associated with Hürthle cell carcinoma and to review the literature regarding this relationship.
  
  
  METHODS
  We describe the clinical, biochemical, radiologic, and pathologic data of a patient with Hürthle cell carcinoma associated with thyrotoxicosis and reversible heart failure. We discuss the mechanistic aspects and review previously reported cases of functional Hürthle cell carcinomas.
  
  
  RESULTS
  A 43-year-old woman presented with thyrotoxicosis and nonischemic cardiomyopathy. She had a "hot" nodule in the left lobe of the thyroid on sodium pertechnetate scan. She underwent a left hemithyroidectomy and isthmusectomy. Pathologic findings revealed a minimally invasive Hürthle cell carcinoma. On follow-up, the dilated cardiomyopathy had resolved. The association of thyroid carcinoma with thyrotoxicosis is rare.
  
  
  CONCLUSIONS
  Some Hürthle cell carcinomas can be functional and lead to thyrotoxicosis. To our knowledge, we present the first case of reversible dilated cardiomyopathy due to thyrotoxicosis originating from Hürthle cell carcinoma.
authors: Department of Medicine, The Methodist Hospital, Houston, Texas 77030, USA. harshakaranchi@gmail.com
authors: Harsha
authors: H
authors: Karanchi
authors: Dale J
authors: DJ
authors: Hamilton
authors: Richard J
authors: RJ
authors: Robbins
mesh_terms: D018249:Adenoma, Oxyphilic / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D000328:Adult; D002311:Cardiomyopathy, Dilated / Q000209:etiology; D005260:Female; D006801:Humans; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D013670:Sodium Pertechnetate Tc 99m; D013964:Thyroid Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D016606:Thyroid Nodule / Q000000981:diagnostic imaging; D013965:Thyroidectomy; D013971:Thyrotoxicosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D014463:Ultrasonography
chemical_list: D019275:Radiopharmaceuticals; D013670:Sodium Pertechnetate Tc 99m