title: [Effect of Limax lyophilized powder on bronchial asthma].
abstract: OBJECTIVE
  To study the effect of Limax lyophilized powder on bronchial asthma.
  
  
  METHODS
  The allergic asthma model was established in guinea pigs by combined utilization of aluminum hydroxide and egg albumin to investigate the effect of Limax lyophilized powder on the bronchial flow and on the level of inflammator in bronchoalveolar lavage and serum.
  
  
  RESULTS
  The mortality of asthma laboratory guinea pigs was reduced and the incubation period of asthma was extended significantly in Limax lyophilized powder groups. Its antiasthmatic effect was as efficient as the control drug (aminophylline). The leucocyte count was decreased in peripheral blood and the bronchoalveolar lavage fluid. The infiltration of pulmonary tissues eosinophil was also significantly reduced. Further more,the most efficient effects was showed in Limax lyophilized powder at the moderate dosage (63 mg/kg). The bronchial perfusion flow was increased and the level of IL-2 and IL-4 in blood serum and bronchoalveolar lavage fluid was decreased obviously in the aminophylline group and Limax lyophilized powder groups at moderate and high dosage.
  
  
  CONCLUSIONS
  Limax lyophilized powder could inhibit bronchial asthma evidently.
authors: Department of Pharmacy, The Third Affiliated Hospital of Guangzhou Medical College, Guangzhou 510150, China. yanpk@tom.com
authors: Peng-ke
authors: PK
authors: Yan
authors: Guang-qing
authors: GQ
authors: Lin
authors: Qi-fu
authors: QF
authors: Luo
authors: Jin-kui
authors: JK
authors: Xie
mesh_terms: D000536:Aluminum Hydroxide; D000628:Aminophylline / Q000627:therapeutic use; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D001980:Bronchi / Q000187:drug effects / Q000473:pathology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D007378:Interleukins / Q000097:blood; D007958:Leukocyte Count; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D008419:Materia Medica / Q000494:pharmacology / Q000627:therapeutic use*; D008974:Mollusca; D010047:Ovalbumin; D011208:Powders; D011897:Random Allocation
chemical_list: D018927:Anti-Asthmatic Agents; D007378:Interleukins; D008419:Materia Medica; D011208:Powders; D000628:Aminophylline; D000536:Aluminum Hydroxide; D010047:Ovalbumin