title: α1,3 glucans are dispensable in Aspergillus fumigatus.
abstract: A triple α1,3 glucan synthase mutant of Aspergillus fumigatus obtained by successive deletions of the three α1,3 glucan synthase genes (AGS1, AGS2, and AGS3) has a cell wall devoid of α1,3 glucans. The lack of α1,3 glucans affects neither conidial germination nor mycelial vegetative growth and is compensated by an increase in β1,3 glucan and/or chitin content.
authors: Unité des Aspergillus, Institut Pasteur, Paris, France.
authors: Christine
authors: C
authors: Henry
authors: Jean-Paul
authors: JP
authors: Latgé
authors: Anne
authors: A
authors: Beauvais
mesh_terms: D001232:Aspergillus fumigatus / Q000201:enzymology / Q000235:genetics / Q000502:physiology*; D002473:Cell Wall / Q000378:metabolism; D002686:Chitin / Q000378:metabolism; D005656:Fungal Proteins / Q000235:genetics*; D055786:Gene Knockout Techniques; D005818:Genetic Engineering; D005936:Glucans / Q000378:metabolism*; D005964:Glucosyltransferases / Q000235:genetics*; D050296:Microbial Viability; D025282:Mycelium / Q000201:enzymology / Q000235:genetics / Q000502:physiology; D010641:Phenotype; D013172:Spores, Fungal / Q000201:enzymology / Q000235:genetics / Q000502:physiology
chemical_list: D005656:Fungal Proteins; D005936:Glucans; D002686:Chitin; C045788:alpha-1,3-glucan; C040088:1,4-glucan; C036655:1,3-alpha-D-glucan synthase; D005964:Glucosyltransferases