title: Acute psychosis in an adolescent girl during treatment for advanced nodular lymphocyte-predominant Hodgkin's lymphom.
abstract: A 16,5 year old female adolescent was diagnosed with nodular lymphocyte-predominant Hodgkin lymphoma (nLPHL), presenting bilateral inguinal and right iliac lymphadenopathy accompanied by B-symptoms. The patient was due to treatment according to the German Interim Guidelines of HD 2002-Pilot Study with 2x OPPA (vincristine, adriamycine, prednisone, procarbacine) and 2x COPP (cyclophosphamide, vincristine, prednisone, procarbazine) and radiotherapy. After 2x OPPA the patient presented a severe episode of a presumably prednisone-induced acute psychosis with need for psychiatric treatment and change of therapy regimen. She was successfully treated with a chimeric monoclonal anti-CD20 antibody (rituximab) and subsequent radiotherapy.
authors: Klinik für Kinder- und Jugendmedizin, Universitätsklinikum Halle-Wittenberg, Pädiatrie, Halle (Saale), Germany. Christine.Pinkwart@medizin.uni-halle.de
authors: C
authors: C
authors: Pinkwart
authors: M
authors: M
authors: Stiefel
authors: C
authors: C
authors: Mauz-Körholz
authors: D
authors: D
authors: Körholz
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use / Q000633:toxicity*; D014150:Antipsychotic Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D009367:Neoplasm Staging; D011241:Prednisone / Q000008:administration & dosage / Q000633:toxicity*; D011605:Psychoses, Substance-Induced / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D018714:Radiotherapy, Adjuvant
chemical_list: D014150:Antipsychotic Agents; D011241:Prednisone