title: Libraries of 2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-amine derivatives via a multicomponent assembly process/1,3-dipolar cycloaddition strategy.
abstract: A Mannich-type multicomponent assembly process/1,3-dipolar cycloaddition strategy has been developed for the rapid and efficient construction of a parent tetrahydroisoquinoline fused isoxazolidine scaffold, which was subsequently functionalized using well-established protocols to access a diverse 70-membered library of novel 2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline-2-amine derivatives.
authors: Department of Chemistry and Biochemistry, The Texas Institute for Drug and Diagnostic Development, The University of Texas, Austin, 78712, United States.
authors: Brett A
authors: BA
authors: Granger
authors: Kyosuke
authors: K
authors: Kaneda
authors: Stephen F
authors: SF
authors: Martin
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003500:Cyclization; D055808:Drug Discovery / Q000379:methods*; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D007555:Isoxazoles / Q000737:chemistry; D008352:Mannich Bases / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry
chemical_list: D000588:Amines; D007546:Isoquinolines; D007555:Isoxazoles; D008352:Mannich Bases; D010165:Palladium