title: 3,5-diacetyl-1,2,4-triazol bis(4N-substituted thiosemicarbazone) palladium(II) complexes: synthesis, structure, antiproliferative activity and low toxicity on normal kidney cells.
abstract: Treatment of (4)N-monosubstituted bis(thiosemicarbazone) ligands of 3,5-diacetyl-1,2,4-triazol series with lithium tetrachloridopalladate gave the dinuclear complexes of general formula [Pd(μ-H(3)L(1-5))](2), but using dichloridobistriphenylphosphinepalladium(II) salt, the first mononuclear bis(thiosemicarbazone)-palladium-triphenylphosphine complexes of the 3,5-diacetyl-1,2,4-triazol series, [Pd(H(3)L(1-5))PPh(3)], have been obtained. All the compounds have been characterized by elemental analysis and by IR and NMR spectroscopy, and the crystal and molecular structures of dinuclear complexes [Pd(μ-H(3)L(3))](2) and [Pd(μ-H(3)L(5))](2) as well as mononuclear complexes [Pd(H(3)L(1))PPh(3)], [Pd(H(3)L(2))PPh(3)], [Pd(H(3)L(3))PPh(3)] and [Pd(H(3)L(4))PPh(3)] have been determined by X-ray crystallography. The new compounds synthesized have been evaluated for antiproliferative activity in vitro against NCI-H460, A2780 and A2780cisR human cancer cell lines. Subsequent toxicity study, on normal renal LLC-PK1 cells, shows that all compounds investigated exhibit very low toxicity on kidney cells with respect to cisplatin.
authors: Departamento de Química Inorgánica (Módulo 07), Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid, Spain.
authors: Ana I
authors: AI
authors: Matesanz
authors: Carolina
authors: C
authors: Hernández
authors: Ana
authors: A
authors: Rodríguez
authors: Pilar
authors: P
authors: Souza
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000633:toxicity; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000633:toxicity; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D018374:LLC-PK1 Cells; D008958:Models, Molecular; D008968:Molecular Conformation; D010165:Palladium; D013552:Swine; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000633:toxicity
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D013882:Thiosemicarbazones; D010165:Palladium