title: Comparison of standardised dietary folate intake across ten countries participating in the European Prospective Investigation into Cancer and Nutrition.
abstract: Folate plays an important role in the synthesis and methylation of DNA as a cofactor in one-carbon metabolism. Inadequate folate intake has been linked to adverse health events. However, comparable information on dietary folate intake across European countries has never been reported. The objective of the present study was to describe the dietary folate intake and its food sources in ten countries in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. A cross-sectional analysis was conducted in 36 034 participants (aged 35-74 years) who completed a single 24 h dietary recall using a computerised interview software program, EPIC-Soft® (International Agency for Research on Cancer, Lyon). Dietary folate intake was estimated using the standardised EPIC Nutrient DataBase, adjusted for age, energy intake, weight and height and weighted by season and day of recall. Adjusted mean dietary folate intake in most centres ranged from 250 to 350 μg/d in men and 200 to 300 μg/d in women. Folate intake tended to be lower among current smokers and heavier alcohol drinkers and to increase with educational level, especially in women. Supplement users (any types) were likely to report higher dietary folate intake in most centres. Vegetables, cereals and fruits, nuts and seeds were the main contributors to folate intake. Nonetheless, the type and pattern of consumption of these main food items varied across the centres. These first comparisons of standardised dietary folate intakes across different European populations show moderate regional differences (except the UK health conscious group), and variation by sex, educational level, smoking and alcohol-drinking status, and supplement use.
authors: Section of Nutrition and Metabolism, International Agency for Research on Cancer, 150 cours Albert-Thomas, 69372 Lyon Cedex 08, France. parkjy@fellows.iarc.fr
authors: Jin Young
authors: JY
authors: Park
authors: Genevieve
authors: G
authors: Nicolas
authors: Heinz
authors: H
authors: Freisling
authors: Carine
authors: C
authors: Biessy
authors: Augustin
authors: A
authors: Scalbert
authors: Isabelle
authors: I
authors: Romieu
authors: Véronique
authors: V
authors: Chajès
authors: Shu-Chun
authors: SC
authors: Chuang
authors: Ulrika
authors: U
authors: Ericson
authors: Peter
authors: P
authors: Wallström
authors: Martine M
authors: MM
authors: Ros
authors: Petra H M
authors: PH
authors: Peeters
authors: Amalia
authors: A
authors: Mattiello
authors: Domenico
authors: D
authors: Palli
authors: José
authors: J
authors: María Huerta
authors: Pilar
authors: P
authors: Amiano
authors: Jytte
authors: J
authors: Halkjær
authors: Christina C
authors: CC
authors: Dahm
authors: Antonia
authors: A
authors: Trichopoulou
authors: Philippos
authors: P
authors: Orfanos
authors: Birgit
authors: B
authors: Teucher
authors: Silke
authors: S
authors: Feller
authors: Guri
authors: G
authors: Skeie
authors: Dagrun
authors: D
authors: Engeset
authors: Marie-Christine
authors: MC
authors: Boutron-Ruault
authors: Françoise
authors: F
authors: Clavel-Chapelon
authors: Francesca
authors: F
authors: Crowe
authors: Kay-Tee
authors: KT
authors: Khaw
authors: Paolo
authors: P
authors: Vineis
authors: Nadia
authors: N
authors: Slimani
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004032:Diet; D004034:Diet Surveys; D005060:Europe; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology* / Q000209:etiology; D012621:Seasons
chemical_list: D005492:Folic Acid