title: Glucocorticoid resistance in paediatric acute lymphoblastic leukaemia.
abstract: Glucocorticoids (GCs), such as prednisolone and dexamethasone, are key components in multi-agent chemotherapy protocols used for the treatment of acute lymphoblastic leukaemia (ALL). Approximately 10% of children with ALL will respond poorly to GCs, and GC resistance is associated with a significantly inferior outcome. This review summarises the current knowledge of GC resistance in ALL, including the roles of the GC receptor and its co-chaperone molecules, the pro-apoptotic and pro-survival B-cell lymphoma 2 family members and alternative non-apoptotic mechanisms of cell death. It concludes with a discussion on therapeutic attempts to overcome GC resistance.
authors: Centre for Children's Cancer and Blood Disorders, Sydney Children's Hospital, Randwick, NSW 2031, Australia. vbhadri@ccia.unsw.edu.au
authors: Vivek A
authors: VA
authors: Bhadri
authors: Toby N
authors: TN
authors: Trahair
authors: Richard B
authors: RB
authors: Lock
mesh_terms: D002648:Child; D019008:Drug Resistance, Neoplasm; D005938:Glucocorticoids / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism
chemical_list: D005938:Glucocorticoids; D019253:Proto-Oncogene Proteins c-bcl-2