title: Multitarget-directed ligands: innovative chemical probes and therapeutic tools against Alzheimer's disease.
abstract: Multitarget agents directed at selected molecular targets involved in the pathogenic cascade of Alzheimer's disease (AD) have been increasingly sought after in recent years, with the aim of achieving enhanced therapeutic efficiency with respect to single-target drugs and drug candidates. At the same time, much attention has been devoted to identifying high quality pharmacological tools to help explore the molecular mechanisms underlying AD without being exposed to physicochemical challenges. Herein, we discuss several examples of both types of compounds, taken from our own research and derived from the leads memoquin, lipocrine and bis(7)tacrine.
authors: Department of Pharmaceutical Sciences, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy. marialaura.bolognesi@unibo.it
authors: Maria Laura
authors: ML
authors: Bolognesi
authors: Elena
authors: E
authors: Simoni
authors: Michela
authors: M
authors: Rosini
authors: Anna
authors: A
authors: Minarini
authors: Vincenzo
authors: V
authors: Tumiatti
authors: Carlo
authors: C
authors: Melchiorre
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000473:Alkanes / Q000737:chemistry / Q000494:pharmacology*; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000201:enzymology; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors; D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D005021:Ethylamines / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008024:Ligands; D013619:Tacrine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D008063:Thioctic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
chemical_list: C122128:1,7-N-heptylene-bis-9,9'-amino-1,2,3,4-tetrahydroacridine; D000473:Alkanes; D016229:Amyloid beta-Peptides; D004791:Enzyme Inhibitors; D005021:Ethylamines; D008024:Ligands; C540521:lipocrine; C521476:memoquin; D013619:Tacrine; D008063:Thioctic Acid; D000110:Acetylcholinesterase