title: Partial hydrodynamic screening of confined linear and circular double-stranded DNA dynamics.
abstract: We performed experiments and simulations to investigate the influence of hydrodynamic interaction on the diffusion dynamics of circular and linear λ-DNA confined in nanoslits. Contrary to the common assumption that intrachain hydrodynamic interaction (HI) is completely screened when polymers are confined in channels with height h smaller than the radius of gyration R(g), it is found that the HI is partially screened and approaches complete screening only for R(g)≪h. For λ-DNA, the HI becomes nearly completely screened only when the channel height is smaller than the Kuhn length. In addition, the dynamics of linear and circular λ-DNA in very strong confinement is shown to be independent of the chain topology.
authors: Institute of Physics, Academia Sinica, Taipei, 11529, Taiwan, Republic of China.
authors: P-K
authors: PK
authors: Lin
authors: J-F
authors: JF
authors: Chang
authors: C-H
authors: CH
authors: Wei
authors: P H
authors: PH
authors: Tsao
authors: W S
authors: WS
authors: Fann
authors: Y-L
authors: YL
authors: Chen
mesh_terms: D003198:Computer Simulation; D004247:DNA / Q000737:chemistry* / Q000648:ultrastructure*; D008956:Models, Chemical; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D014867:Water / Q000737:chemistry*
chemical_list: D014867:Water; D004247:DNA