title: Synthesis and in vitro characterization of semitelechelic poly[N-(2-hydroxypropyl)methacrylamide]-trastuzumab conjugates targeted to breast cancer.
abstract: Trastuzumab (TRZ) is a humanized monoclonal antibody that targets the extracellular domain of the human epidermal growth factor receptor type 2 (Her2). Semitelechelic (ST) poly[N-(2-hydroxypropyl)methacrylamide]-TRZ conjugates are successfully synthesized and evaluated as a potential drug delivery system that actively targets Her2-overexpressing cancer cells. The ST backbone shows favorable characteristics when conjugated to TRZ. The conjugate exhibits comparable and prolonged anticancer activity when compared to free TRZ in Her2 overexpressing breast cancer cell lines.
authors: Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, MD 21201, USA.
authors: Jun H
authors: JH
authors: Lee
authors: Gauri
authors: G
authors: Sabnis
authors: Anjan
authors: A
authors: Nan
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage* / Q000737:chemistry; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000138:chemical synthesis* / Q000737:chemistry; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002470:Cell Survival; D016503:Drug Delivery Systems / Q000379:methods; D005260:Female; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D011109:Polymethacrylic Acids / Q000008:administration & dosage* / Q000138:chemical synthesis* / Q000737:chemistry; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D000068878:Trastuzumab; D014407:Tumor Cells, Cultured
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D020928:Mitogen-Activated Protein Kinases; D011109:Polymethacrylic Acids; D018719:Erb-b2 Receptor Tyrosine Kinases; D000068878:Trastuzumab; C011533:Duxon