title: [Origin and evolution of canine parvovirus--a review].
abstract: Canine parvovirus (CPV-2), first recognized in 1978 as a new pathogen of dogs, was probably derived from a very closely related virus in cats, feline panleukopaenia virus (FPLV) or a closely related carnivore parvovirus (FPLV-like virus). CPV-2 is responsible for either myocarditis or fatal gastroenteritis in pups with high morbidity and mortality. Shortly after its emergence, CPV-2 has become endemic in the global dog population. The original CPV-2 continued to evolve, and was subsequently replaced by three different but closely related antigenic variants, designated CPV-2a, CPV-2b and CPV-2c, which now coexist in dog populations worldwide. The genetic and antigenic variation in CPV-2 also correlated with changes in the host range and tissue tropisms of the virus. Here, we reviewed variation and evolution of CPV-2 in past 30 years and discussed CPV-2 as an important model to study virus evolution.
authors: Division of Preventive Veterinary Medicine, Institute of Special Economic Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Jilin 132109, China. jianjunzhao2004@yahoo.com.cn
authors: Jianjun
authors: J
authors: Zhao
authors: Xijun
authors: X
authors: Yan
authors: Wei
authors: W
authors: Wu
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000235:genetics; D004285:Dogs; D019143:Evolution, Molecular; D009154:Mutation; D017993:Parvovirus, Canine / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D014765:Viral Vaccines / Q000276:immunology
chemical_list: D000956:Antigens, Viral; D014765:Viral Vaccines