title: Spectrofluorimetric assessment of chlorzoxazone and ibuprofen in pharmaceutical formulations by using Eu-tetracycline HCl optical sensor doped in sol-gel matrix.
abstract: A novel, simple, sensitive and selective spectrofluorimetric method was developed for the determination of trace amounts of chlorzoxazone and Ibuprofen in pharmaceutical tablets using optical sensor Eu-Tetracycline HCl doped in sol-gel matrix. The chlorzoxazone or Ibuprofen can remarkably enhance the luminescence intensity of Eu-Tetracycline HCl complex doped in a sol-gel matrix in dimethylformamide (DMF) at pH 9.7 and 6.3, respectively, λ(ex) = 400 nm. The enhancing of luminescence intensity peak of Eu-Tetracycline HCl complex at 617 nm is proportional to the concentration of chlorzoxazone or Ibuprofen a result that suggested profitable application as a simple optical sensor for chlorzoxazone or Ibuprofen assessment. The dynamic ranges found for the determination of chlorzoxazone and Ibuprofen concentration are 5 × 10(-9)-1 × 10(-4) and 1 × 10(-8)-7 × 10(-5) mol L(-1), and the limit of detection (LOD) and quantitation limit of detection (LOQ) are 3.1 × 10(-10), 9.6 × 10(-10) and 5.6 × 10(-10), 1.7 × 10(-9) mol L(-1), respectively.
authors: Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt. Mohamed_sam@yahoo.com
authors: M S
authors: MS
authors: Attia
authors: M N
authors: MN
authors: Ramsis
authors: L H
authors: LH
authors: Khalil
authors: S G
authors: SG
authors: Hashem
mesh_terms: D002753:Chlorzoxazone / Q000032:analysis*; D004126:Dimethylformamide / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D005782:Gels / Q000737:chemistry; D007052:Ibuprofen / Q000032:analysis*; D049449:Luminescence; D015394:Molecular Structure; D055096:Optical Devices; D009942:Organometallic Compounds / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000032:analysis*; D013050:Spectrometry, Fluorescence / Q000379:methods*; D013607:Tablets / Q000737:chemistry; D013754:Tetracyclines / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; D005782:Gels; D009942:Organometallic Compounds; D004364:Pharmaceutical Preparations; D013607:Tablets; D013754:Tetracyclines; C488317:europium(III) tetracycline; D004126:Dimethylformamide; D002753:Chlorzoxazone; D007052:Ibuprofen