title: Hypervascular hepatocellular carcinomas: detection with gadoxetate disodium-enhanced MR imaging and multiphasic multidetector CT.
abstract: OBJECTIVE
  To retrospectively compare the accuracy of detection of hypervascular hepatocellular carcinoma (HCC) by multiphasic multidetector CT and by gadoxetate disodium-enhanced MR imaging.
  
  
  METHODS
  After ethical approval, we analysed a total of 73 hypervascular HCC lesions from 31 patients suspected of having HCC, who underwent both gadoxetate disodium-enhanced MR imaging and multiphasic multidetector CT. Five blinded observers independently reviewed CT images, as well as dynamic MR images alone and combined with hepatobiliary phase MR images. Diagnostic accuracy (Az values), sensitivities and positive predictive values were compared by using the Scheffe post hoc test.
  
  
  RESULTS
  The mean Az value for dynamic and hepatobiliary phase MR combined (0.81) or dynamic MR images alone (0.78) was significantly higher than that for CT images (0.67, P < 0.001, 0.005, respectively). The mean sensitivity of the combined MR images (0.67) was significantly higher than that of dynamic MR alone (0.52, P < 0.05) or CT images (0.44, P < 0.05). The mean positive predictive values were 0.96, 0.95 and 0.94, for CT, dynamic MR alone and combined MR images, respectively.
  
  
  CONCLUSIONS
  Compared with multiphasic multidetector CT, gadoxetate disodium-enhanced MR imaging combining dynamic and hepatobiliary phase images results in significantly improved sensitivity and diagnostic accuracy for detection of hypervascular HCC.
  
  
  CONCLUSIONS
  Gadoxetate disodium is a new liver-specific MR imaging contrast agent. Gadoxetate disodium-enhanced MRI helps the assessment of patients with liver disease. It showed high diagnostic accuracy for the detection of hepatocellular carcinoma.
authors: Department of Radiology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan. h-onishi@iris.dti.ne.jp
authors: Hiromitsu
authors: H
authors: Onishi
authors: Tonsok
authors: T
authors: Kim
authors: Yasuharu
authors: Y
authors: Imai
authors: Masatoshi
authors: M
authors: Hori
authors: Hiroaki
authors: H
authors: Nagano
authors: Yasuhiro
authors: Y
authors: Nakaya
authors: Takahiro
authors: T
authors: Tsuboyama
authors: Atsushi
authors: A
authors: Nakamoto
authors: Mitsuaki
authors: M
authors: Tatsumi
authors: Seishi
authors: S
authors: Kumano
authors: Masahiro
authors: M
authors: Okada
authors: Manabu
authors: M
authors: Takamura
authors: Kenichi
authors: K
authors: Wakasa
authors: Noriyuki
authors: N
authors: Tomiyama
authors: Takamichi
authors: T
authors: Murakami
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis*; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000175:diagnosis*; D015588:Observer Variation; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA