title: Chemical proteomics in drug discovery.
abstract: Real-world drug discovery and development remains a notoriously unproductive and increasingly uneconomical process even in the Omics era. The dominating paradigm in the industry continues to be target-based drug design, with an increased perception of the role of signaling pathways in homeostasis and in disease. Since proteins represent the major type of drug targets, proteomics-based approaches, which study proteins under relatively physiological conditions, have great potential if they can be reduced to practice such that they successfully complement the arsenal of drug discovery techniques. This chapter discusses examples of drug discovery processes where chemical proteomics-based assays using native endogenous proteins should have substantial impact.
authors: Cellzome AG, Heidelberg, Germany. Gerard.Drewes@cellzome.com
authors: Gerard
authors: G
authors: Drewes
mesh_terms: D016503:Drug Delivery Systems; D055808:Drug Discovery / Q000379:methods*; D040901:Proteomics / Q000379:methods*; D015203:Reproducibility of Results; D054852:Small Molecule Libraries / Q000032:analysis / Q000494:pharmacology
chemical_list: D054852:Small Molecule Libraries