title: Extended follow-up and outcomes of patients undergoing pancreaticoduodenectomy for nonmalignant disease.
abstract: BACKGROUND
  Due to improved surgical outcomes and increased detection of pancreatic lesions, the resection of nonmalignant and indeterminate lesions of the pancreas has increased.
  
  
  OBJECTIVE
  This study aims to assess the outcomes over an extended period of time and the clinical consequences of pancreaticoduodenectomy (PD) performed for nonmalignant indications.
  
  
  METHODS
  Patients undergoing a PD between 2006 and 2010 were retrospectively identified and asked to complete a symptom survey. Charts were reviewed for hospital admissions, emergency room visits, complications, and procedures performed.
  
  
  RESULTS
  A total of 132 patients were identified through database review with a median follow-up of 2.8 years. Forty-two patients (31.1%) completed the phone survey. Pain and diarrhea were the most common symptoms reported, negatively impacting the patient's daily life in 4.9% and 7.3% of patients, respectively. Diabetes developed or worsened in 19.5%, with new insulin required in 12.2%. Complications were rare, with abdominal abscess (7.6%) occurring most commonly.
  
  
  CONCLUSIONS
  Although some patients experienced symptoms that negatively impacted their daily life or had diabetic issues following surgery, the outcome of patients undergoing PD for nonmalignant indications was generally favorable. Further prospective study is warranted.
authors: Department of Gastroenterology and Hepatology, Thomas Jefferson University, 132 South 10th Street, Main Building, Suite 480, Philadelphia, PA 19107, USA.
authors: Nicholas Thomas
authors: NT
authors: Orfanidis
authors: David E
authors: DE
authors: Loren
authors: Carmi
authors: C
authors: Santos
authors: Eugene P
authors: EP
authors: Kennedy
authors: Ali A
authors: AA
authors: Siddiqui
authors: Harish
authors: H
authors: Lavu
authors: Charles J
authors: CJ
authors: Yeo
authors: Thomas E
authors: TE
authors: Kowalski
mesh_terms: D018784:Abdominal Abscess / Q000209:etiology; D015746:Abdominal Pain / Q000209:etiology*; D000368:Aged; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000209:etiology*; D003967:Diarrhea / Q000209:etiology*; D004632:Emergency Medical Services; D005260:Female; D005500:Follow-Up Studies; D006760:Hospitalization; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010182:Pancreatic Diseases / Q000473:pathology* / Q000601:surgery*; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000601:surgery; D016577:Pancreaticoduodenectomy / Q000009:adverse effects*; D011788:Quality of Life; D012189:Retrospective Studies
chemical_list: D007328:Insulin