title: The role of MAPK in CD4(+) T cells toll-like receptor 9-mediated signaling following HHV-6 infection.
abstract: Human herpesvirus-6 (HHV-6) is an important immunosuppressive and immunomodulatory virus that primarily infects immune cells (mainly CD4(+) T cells) and strongly suppresses the proliferation of infected cells. Toll-like receptors are pattern-recognition receptors essential for the development of an appropriate innate immune defense against infection. To understand the role of CD4(+) T cells in the innate response to HHV-6 infection and the involvement of TLRs, we used an in vitro infection model and observed that the infection of CD4(+) T cells resulted in the activation of JNK/SAPK via up-regulation of toll-like receptor 9 (TLR9). Associated with JNK activation, annexin V-PI staining indicated that HHV-6A was a strong inducer of apoptosis. Apoptotic response associated cytokines, IL-6 and TNF-α also induced by HHV-6A infection.
authors: Department of Microbiology and Immunology, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors: Jing
authors: J
authors: Chi
authors: Fang
authors: F
authors: Wang
authors: Lingyun
authors: L
authors: Li
authors: Dongju
authors: D
authors: Feng
authors: Jian
authors: J
authors: Qin
authors: Fangyi
authors: F
authors: Xie
authors: Feng
authors: F
authors: Zhou
authors: Yun
authors: Y
authors: Chen
authors: Jinfeng
authors: J
authors: Wang
authors: Kun
authors: K
authors: Yao
mesh_terms: D017304:Annexin A5 / Q000096:biosynthesis; D017209:Apoptosis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism / Q000821:virology*; D002460:Cell Line; D049109:Cell Proliferation; D015654:Herpesvirus 6, Human / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis; D048031:JNK Mitogen-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism*; D020935:MAP Kinase Signaling System; D012367:RNA, Viral / Q000096:biosynthesis; D019349:Roseolovirus Infections / Q000276:immunology / Q000378:metabolism; D051217:Toll-Like Receptor 9 / Q000235:genetics / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
chemical_list: D017304:Annexin A5; D015850:Interleukin-6; D012367:RNA, Viral; D051217:Toll-Like Receptor 9; D014409:Tumor Necrosis Factor-alpha; D048031:JNK Mitogen-Activated Protein Kinases