title: Dual anticancer activity in a single compound: visible-light-induced apoptosis by an antiangiogenic iridium complex.
abstract: A metal complex is identified in which the metal fulfills two independent functions: as a structural scaffold for the specific molecular recognition of protein kinases resulting in antiangiogenic properties, together with a visible-light-induced photoreactivity triggering apopotosis in cancer cells.
authors: Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Strasse, 35043 Marburg, Germany.
authors: Anja
authors: A
authors: Kastl
authors: Alexander
authors: A
authors: Wilbuer
authors: Anna Lena
authors: AL
authors: Merkel
authors: Li
authors: L
authors: Feng
authors: Pietro
authors: P
authors: Di Fazio
authors: Matthias
authors: M
authors: Ocker
authors: Eric
authors: E
authors: Meggers
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects* / Q000528:radiation effects*; D006367:HeLa Cells; D006801:Humans; D007495:Iridium / Q000737:chemistry*; D008027:Light; D009389:Neovascularization, Pathologic / Q000188:drug therapy; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D020533:Angiogenesis Inhibitors; D009942:Organometallic Compounds; D007495:Iridium