title: Study of the cytogenetic and non-cytogenetic factors in cervical carcinoma in the Jammu region of J and K state.
abstract: OBJECTIVE
  The present study was aimed to analyze the chromosomal changes and also to work out the association of some of the non-cytogenetic factors in the confirmed cases of cervical carcinoma.
  
  
  METHODS
  Slides for the chromosome study were prepared from the tumor growths of 78 patients as the diagnosed cases of cervical carcinoma. The slides so prepared were then subjected to G-banding to rule the involvement of different chromosomes in the progression of cervical cancer. Non-cytogenetic factors that are considered to be the risk factors for CaCx were also taken up during the present study to study the etiology of cervical cancer.
  
  
  RESULTS
  Both the numerical and the structural chromosomal changes have been recorded in a majority of these growths. In most of the cases, numerical chromosomal changes (95%) outnumbered the structural aberrations.
  
  
  CONCLUSIONS
  Aneuploidy was the most common numerical chromosomal aberration recorded in the majority of the tumor growths. Structural aberrations included translocations and deletions. Non-cytogenetic factors like multiparity, early marriage, poor genital hygiene and rural background were highly prevalent in the present study.
authors: Institute of Human Genetics, University of Jammu, Jammu and Kashmir, India. roopali30@gmail.com
authors: Roopali
authors: R
authors: Fotra
authors: Shashi
authors: S
authors: Gupta
authors: Subash
authors: S
authors: Gupta
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000782:Aneuploidy; D002294:Carcinoma, Squamous Cell / Q000235:genetics; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002877:Chromosomes, Human; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D014178:Translocation, Genetic; D002583:Uterine Cervical Neoplasms / Q000235:genetics*