title: [Whey protein improves insulin resistance via the increase of antioxidant capacity in model rats].
abstract: OBJECTIVE
  To investigate the effects of whey protein on insulin resistance in model rats.
  
  
  METHODS
  Insulin resistance model rats were established by feeding high-fat diet in Wistar rats. Model rats were then randomly divided into 4 groups of 10 animals each and fed on 0% whey protein (WP), 5% WP and 15% WP. After 8 weeks, fasting blood glucose (FBG), fasting plasma insulin (FINS) were determined. Oral glucose tolerance test (OGTT) was performed and glucose area under the curve (AUC) was calculated. Also, plasma total anti-oxidation capacity (T-AOC), superoxide dismutase (SOD), reduced glutathione hormone (GSH) and malondialdehyde (MDA) were determined.
  
  
  RESULTS
  Whey protein intake did not affected FBG and glucose AUC. FINS and homeostatic model assessment-insulin resistance (HOMA-IR) were significantly lower in 15% WP group than in 0% WP group. For antioxidant index,plasma level of T-AOC, SOD and GSH were significantly higher in 15% WP group than in 0% WP group (T-AOC : P < 0.01; SOD, GSH : P < 0.05); however, MDA was significantly lower in 15% WP group than in 0% WP group (P < 0.05).
  
  
  CONCLUSIONS
  Whey protein improves insulin resistance. This effect is related to the increase of antioxidant capacity in insulin resistance model rats.
authors: Department of Nutrition and Food Hygiene, School of Radiation Medicine and Public Health, Soochow University, Suzhou 215123, China.
authors: Xing
authors: X
authors: Tong
authors: Jiaying
authors: J
authors: Dong
authors: Zhiwei
authors: Z
authors: Wu
authors: Wei
authors: W
authors: Li
authors: Liqiang
authors: L
authors: Qin
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D004041:Dietary Fats / Q000008:administration & dosage*; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008894:Milk Proteins / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D000067816:Whey Proteins
chemical_list: D000975:Antioxidants; D004041:Dietary Fats; D008894:Milk Proteins; D000067816:Whey Proteins