title: Skin sympathetic nerve activity component synchronizing with cardiac cycle is involved in hypovolaemic suppression of cutaneous vasodilatation in hyperthermia.
abstract: Although cutaneous vasodilatation in hyperthermia was suppressed during hypovolaemia, the efferent neural pathway mediating this suppression has not been identified. To determine the electrical nerve signals which account for the suppression of cutaneous vasodilatation during hypovolaemia, skin sympathetic nerve activity (SSNA; microneurography) from the peroneal nerve, laser-Doppler blood flow (LDF) on the ipsilateral dorsal foot, mean arterial pressure (MAP; sonometry) and oesophageal temperature (T(oes)) were measured before and during 45 min of passive warming in 20 healthy subjects during normovolaemia (n = 10) or hypovolaemia (n = 10) conditions. Hypovolaemia was achieved by diuretic administration. Cutaneous vascular conductance (CVC = LDF/MAP), SSNA burst frequency and total SSNA obtained from rectified and filtered SSNA signal increased as T(oes) increased by ~0.5°C by the end of warming in both groups. The increase in CVC was significantly lower in hypovolaemia than normovolaemia (P < 0.0001), but with no significant difference in the increase in burst frequency and total SSNA between groups (P > 0.32). However, using an alternative analysis that constructed spike incidence histograms from the original signal using 0.05 s bins during the 5 s following a given R-wave, we found a SSNA component synchronized with the cardiac cycle with a 1.1-1.3 s latency. This component increased with an increase in T(oes) and the increase was significantly suppressed by hypovolaemia (P < 0.0001). In conclusion, hypovolaemic suppression of cutaneous vasodilatation during hyperthermia might be caused by a reduction in the SSNA component synchronized with cardiac cycle.
authors: Department of Sports Medical Sciences, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Matsumoto 390-8621, Japan. yoshikmj@shinshu-u.ac.jp
authors: Yoshi-ichiro
authors: Y
authors: Kamijo
authors: Yoshiyuki
authors: Y
authors: Okada
authors: Shigeki
authors: S
authors: Ikegawa
authors: Kazunobu
authors: K
authors: Okazaki
authors: Masaki
authors: M
authors: Goto
authors: Hiroshi
authors: H
authors: Nose
mesh_terms: D000328:Adult; D001831:Body Temperature; D005334:Fever / Q000503:physiopathology*; D006321:Heart / Q000502:physiology*; D006801:Humans; D020896:Hypovolemia / Q000503:physiopathology*; D008297:Male; D009476:Neurons, Efferent / Q000502:physiology; D012867:Skin / Q000294:innervation*; D012879:Skin Physiological Phenomena; D013564:Sympathetic Nervous System / Q000502:physiology*; D014664:Vasodilation / Q000502:physiology; D055815:Young Adult