title: Capsule-endoscopic findings of ulcerative colitis patients.
abstract: OBJECTIVE
  Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by diffuse mucosal inflammation, traditionally regarded as being limited to the colorectum. Although several gastroduodenal lesions have also been reported recently in cases of UC, in general, small-bowel lesions in UC are believed to be extremely rare. The aim of this study was to examine the small bowel by capsule endoscopy in patients with UC.
  
  
  METHODS
  The study was conducted in 23 well-documented UC patients and 23 control volunteers. The frequency of small-bowel lesions, the number of small-bowel lesions per patient and the capsule endoscopy score were comparatively evaluated between the two groups.
  
  
  RESULTS
  Of the 23 UC patients, 13 (57%) showed small-bowel lesions, and 8 (35%) had erosions. There were significant differences in the frequency of the small-bowel lesions (p < 0.001) and erosions (p = 0.009) between the two groups. The capsule endoscopy score was correlated with the UC disease activity index (r = 0.718, p < 0.001).
  
  
  CONCLUSIONS
  This is the first capsule-endoscopic study conducted to examine the small-bowel involvement in UC patients as compared with the healthy volunteers. It was concluded that UC, a chronic inflammatory bowel disease, can also involve the small bowel.
authors: Division of Gastroenterology, Yokohama City University School of Medicine, Kanazawa-ku, Yokohama, Japan.
authors: Takuma
authors: T
authors: Higurashi
authors: Hiroki
authors: H
authors: Endo
authors: Masato
authors: M
authors: Yoneda
authors: Kunihiro
authors: K
authors: Hosono
authors: Eiji
authors: E
authors: Sakai
authors: Hirokazu
authors: H
authors: Takahashi
authors: Masahiko
authors: M
authors: Inamori
authors: Shiori
authors: S
authors: Uchiyama
authors: Takuto
authors: T
authors: Kojima
authors: Kenichi
authors: K
authors: Kawana
authors: Yutaka
authors: Y
authors: Natsumeda
authors: Hajime
authors: H
authors: Nagase
authors: Atsushi
authors: A
authors: Nakajima
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D053704:Capsule Endoscopy; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007421:Intestine, Small / Q000473:pathology*; D008297:Male; D019804:Mesalamine / Q000627:therapeutic use; D008875:Middle Aged; D052016:Mucositis / Q000150:complications* / Q000175:diagnosis; D011239:Prednisolone / Q000627:therapeutic use; D011446:Prospective Studies; D012720:Severity of Illness Index; D016037:Single-Blind Method; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005938:Glucocorticoids; D019804:Mesalamine; D011239:Prednisolone