title: Stress hyperglycemia: a sign of familial diabetes in children.
abstract: Stress hyperglycemia in children is considered a benign condition that usually does not mandate further investigation. In some clinical settings it might be the first sign of diabetes mellitus (DM). Two unrelated boys, one aged 2 years 7 months and the other aged 5 days, were evaluated in the emergency department for a febrile infection and found to have elevated blood glucose levels (238 and 150 mg/dL [preprandial], respectively). In both cases the elevated hemoglobin A1c levels (6.5% and 6.6%, respectively) combined with a history of gestational DM in the mother and positive family history for DM suggested maturity-onset diabetes of the young. Genetic analysis revealed 2 known heterozygote mutations in the glucokinase gene: c.697T→C p.C233R in the first case and c.616A→C p.T206P in the second case. Our findings suggest that stress hyperglycemia during early childhood in association with a positive family history of DM might be a sign of monogenic diabetes.
authors: National Center for Childhood Diabetes, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
authors: Tal
authors: T
authors: Oron
authors: Galia
authors: G
authors: Gat-Yablonski
authors: Liora
authors: L
authors: Lazar
authors: Moshe
authors: M
authors: Phillip
authors: Yael
authors: Y
authors: Gozlan
mesh_terms: D002648:Child; D002675:Child, Preschool; D003920:Diabetes Mellitus / Q000175:diagnosis* / Q000235:genetics*; D006801:Humans; D006943:Hyperglycemia / Q000235:genetics*; D007231:Infant, Newborn; D008297:Male; D013312:Stress, Physiological