title: Biotic transformation of anticoccidials in soil using a lab-scale bio-reactor as a precursor-tool.
abstract: Two anticoccidial agents, salinomycin and robenidine, heavily used in the worldwide veterinary meat production, were investigated for their potential biotic degradation by cultured soil bacteria. The degradation-study was performed in lab-scale bio-reactors under aerobic and anaerobic conditions incubated for 200 h with a mixed culture of soil bacteria. Samples were analyzed by LC-MS/MS and potential transformation products were tentatively identified. Salinomycin was degraded under aerobic conditions and traces could be found after 200 h, however, seems more persistent under anaerobic conditions. Four transformation products of salinomycin were discovered. Robenidine was degraded under aerobic and anaerobic conditions, however, traces of robenidine were observed after 200 h. Five biotic transformation products of robenidine were discovered.
authors: Section of Toxicology and Environmental Chemistry, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. mah@farma.ku.dk
authors: Martin
authors: M
authors: Hansen
authors: Erland
authors: E
authors: Björklund
authors: Kristine A
authors: KA
authors: Krogh
authors: Asbjørn
authors: A
authors: Brandt
authors: Bent
authors: B
authors: Halling-Sørensen
mesh_terms: D001673:Biodegradation, Environmental; D019149:Bioreactors; D002851:Chromatography, High Pressure Liquid; D003049:Coccidiostats / Q000032:analysis / Q000378:metabolism*; D011714:Pyrans / Q000032:analysis / Q000378:metabolism; D012370:Robenidine / Q000032:analysis / Q000378:metabolism; D012988:Soil Microbiology; D012989:Soil Pollutants / Q000032:analysis / Q000378:metabolism*; D053719:Tandem Mass Spectrometry; D013997:Time Factors; D000095662:Polyether Polyketides
chemical_list: D003049:Coccidiostats; D011714:Pyrans; D012370:Robenidine; D012989:Soil Pollutants; C010327:salinomycin; D000095662:Polyether Polyketides