title: Triple-negative breast cancers and the human mammary epithelial cell hierarchy.
abstract: Triple-negative breast cancers (TNBCs) are a diverse set of aggressive breast cancers that lack expression of estrogen and progesterone receptors, and lack HER2 amplification. Gene expression profiling has revealed distinct subsets of TNBCs, each characterized by unique patterns of gene expression and genomic changes. Comparative analysis of gene expression profiles also suggests that the different subclasses of TNBCs may arise from specific sets of mammary progenitor cell populations. In this article, recent data regarding characterization of a human mammary stem cell hierarchy and its relationship to the pathogenesis of subsets of triple-negative breast cancers will be reviewed.
authors: Cancer Institute of New Jersey, Robert Wood Johnson Medical School-UMDNJ, New Brunswick, NJ 08903, USA. ganesash@umdnj.edu
authors: Shridar
authors: S
authors: Ganesan
authors: Vassiliki
authors: V
authors: Karantza
authors: Jay
authors: J
authors: Oza
authors: Deborah
authors: D
authors: Toppmeyer
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D004847:Epithelial Cells; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone