title: Green chemistry: solvent- and metal-free Prins cyclization. Application to sequential reactions.
abstract: Prins cyclization between a homoallylic alcohol and an aldehyde, promoted by trimethylsilyl halide, afforded 4-halo-tetrahydropyrans with good to excellent yields. Thanks to the absence of the solvent and metal, the THP thus obtained have been implicated without purification in several other reactions, in a sequential way, affording in particular new indole derivatives.
authors: Université de Lyon, Université Lyon 1, ICBMS, équipe SURCOOF, CNRS, UMR 5246, Bât. Raulin, 43 Bd du 11 Nov. 1918, 69622 Villeurbanne cedex, France.
authors: Damien
authors: D
authors: Clarisse
authors: Béatrice
authors: B
authors: Pelotier
authors: Olivier
authors: O
authors: Piva
authors: Fabienne
authors: F
authors: Fache
mesh_terms: D000438:Alcohols / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry; D003500:Cyclization; D055772:Green Chemistry Technology / Q000379:methods*; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D000447:Aldehydes; D011714:Pyrans; D012822:Silicon Dioxide