title: Chemical constituents of Stereospermum acuminatissimum and their urease and α-chymotrypsin inhibitions.
abstract: Phytochemical investigation of the stem bark of Stereospermum acuminatissimum K. Schum. resulted in the isolation of 21 compounds, including two new guanine derivatives, 1,3,7-trimethylguanin-1/3-ium (1) and 3,7-dimethylguanin-1/3-ium (2), and one new phenolic long chain ester, 2-(4-hydroxyphenyl)ethyl hentriacontanoate (3). The known compounds were identified as sterequinones A, F, and H (4, 5, and 6), zenkequinones A-B (7-8), p-coumaric acid (9), methyl caffeate (10), caffeic acid (11), psilalic acid (12), syringaldehyde (13), norviburtinal (14), specioside (15), verminoside (16), tyrosol (17), eutigoside A (18), ellagic acid (19), atranorin (20), and ursolic acid (21). The metabolites were screened for their potential against urease and α-chymotrypsin enzymes, as urease is targeted in peptic ulcer while α-chymotrypsin is used to remove protein debris in ulcer. Compound 20 was found to be excellent urease inhibitor with IC(50) value of 18.2 ± 0.03 μM. Compounds 13 and 18-20 are reported for the first time from the genus Stereospermum. The chemotaxonomic significance of the isolated compounds was also described.
authors: Department of Organic Chemistry, Higher Teachers Training College, University of Yaounde I, P. O. Box 47, Yaounde, Cameroon.
authors: Kamdem Soup T
authors: KS
authors: Ramsay
authors: Pascal
authors: P
authors: Wafo
authors: Zulfiqar
authors: Z
authors: Ali
authors: Ajmal
authors: A
authors: Khan
authors: Ogbole O
authors: OO
authors: Oluyemisi
authors: Bishnu P
authors: BP
authors: Marasini
authors: Ikhlas A
authors: IA
authors: Khan
authors: Ngadjui T
authors: NT
authors: Bonaventure
authors: M Iqbal
authors: MI
authors: Choudhary
authors: Atta-ur-Rahman
mesh_terms: D000880:Anthraquinones / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D029402:Bignoniaceae / Q000737:chemistry* / Q000378:metabolism; D015415:Biomarkers; D039823:Iridoids / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D015394:Molecular Structure; D014510:Urease / Q000037:antagonists & inhibitors*
chemical_list: D000880:Anthraquinones; D015415:Biomarkers; D039823:Iridoids; D014510:Urease