title: Serological monitoring of protection of sheep against Echinococcus granulosus induced by the EG95 vaccine.
abstract: Although immunity to Echinococcus granulosus in sheep has been shown to be antibody-mediated and complement-dependent and can be passively transferred in colostrum, in animals vaccinated with EG95, the relationship between protection against an oral challenge infection with E. granulosus eggs and anti-EG95 IgG ELISA absorbance values at the time of challenge has not been satisfactorily proven. Using a combination of results from three EG95 vaccination trials, we have found that the IgG ELISA absorbance at the time of challenge infection explains approximately 50% (P ≤ 0·001) of the variability in the percentage protection against an oral challenge with E. granulosus eggs (transformed with arcsin).
authors: Animal Health Division, AgResearch New Zealand Limited, Palmerston North, New Zealand. david.heath@agresearch.co.nz
authors: D D
authors: DD
authors: Heath
authors: J
authors: J
authors: Koolaard
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood*; D000947:Antigens, Helminth / Q000276:immunology*; D015415:Biomarkers; D004443:Echinococcosis / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D048209:Echinococcus granulosus / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D015801:Helminth Proteins / Q000276:immunology*; D007074:Immunoglobulin G / Q000097:blood; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology / Q000517:prevention & control*; D014612:Vaccines / Q000008:administration & dosage* / Q000276:immunology*
chemical_list: D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D015415:Biomarkers; C446034:EG95 protein, Echinococcus granulosus; D015801:Helminth Proteins; D007074:Immunoglobulin G; D014612:Vaccines