title: Pharmacokinetics of vitexin-4″-O-glucoside in rats after intravenous application.
abstract: Vitexin-4″-O-glucoside (VOG), being a main component in the leaves of Crataegus pinnatifida Bge. var. major, was isolated and then three different doses (20, 40, and 60 mg/kg) of VOG were administered intravenously to rats. To study its pharmacokinetics, a simple and rapid HPLC method was developed using hesperidin as internal standard and the relative parameters were calculated by both compartmental and non-compartmental approach. The results showed that VOG fitted a two-compartment open model. The values of AUC increased proportionally within the range of 20-60 mg/kg. Additionally, α half-life, β half-life, (a)CL, MRT(0→t ), MRT(0→∞ ), and terminal half-life of VOG in rats showed significant differences between 20 mg/kg and other doses. Thereby, VOG presented a dose-dependent pharmacokinetics in the range of 20-60 mg/kg and non-linear pharmacokinetics at lower dose.
authors: School of Pharmacy, Liaoning University of Traditional Chinese Medicine, 77 Shengming 1 Road, DD Port, Dalian, 116600, China.
authors: Xi Xiang
authors: XX
authors: Ying
authors: Fei
authors: F
authors: Wang
authors: Zhong Zhe
authors: ZZ
authors: Cheng
authors: Wen Jie
authors: WJ
authors: Zhang
authors: Hai Bo
authors: HB
authors: Li
authors: Yang
authors: Y
authors: Du
authors: Xun
authors: X
authors: Liu
authors: Si Yuan
authors: SY
authors: Wang
authors: Ting Guo
authors: TG
authors: Kang
mesh_terms: D000818:Animals; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D027825:Crataegus / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D005960:Glucosides / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D006207:Half-Life; D006569:Hesperidin / Q000737:chemistry; D007529:Isoflavones / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D008297:Male; D008954:Models, Biological; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar; D012015:Reference Standards
chemical_list: D005960:Glucosides; D007529:Isoflavones; C477953:isovitexin-4'-O-glucoside; D006569:Hesperidin