title: RAGE does not contribute to renal injury and damage upon ischemia/reperfusion-induced injury.
abstract: The receptor for advanced glycation end products (RAGE) mediates a variety of inflammatory responses in renal diseases, but its role in renal ischemia/reperfusion (I/R) injury is unknown. We showed that during renal I/R, RAGE ligands HMGB1 and S100B are expressed. However, RAGE deficiency does not affect renal injury and function upon I/R-induced injury.
authors: Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. m.c.dessing@amc.uva.nl
authors: Mark C
authors: MC
authors: Dessing
authors: Wilco P
authors: WP
authors: Pulskens
authors: Gwendoline J
authors: GJ
authors: Teske
authors: Loes M
authors: LM
authors: Butter
authors: Tom
authors: T
authors: van der Poll
authors: Huan
authors: H
authors: Yang
authors: Kevin J
authors: KJ
authors: Tracey
authors: Peter P
authors: PP
authors: Nawroth
authors: Angelika
authors: A
authors: Bierhaus
authors: Sandrine
authors: S
authors: Florquin
authors: Jaklien C
authors: JC
authors: Leemans
mesh_terms: D000818:Animals; D050476:Bowman Capsule / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D005786:Gene Expression Regulation / Q000235:genetics / Q000276:immunology; D024243:HMGB1 Protein / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology; D007674:Kidney Diseases / Q000235:genetics / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D007687:Kidney Tubules, Proximal / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D051379:Mice; D018345:Mice, Knockout; D009414:Nerve Growth Factors / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology; D050199:Podocytes / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D015427:Reperfusion Injury / Q000235:genetics / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology
chemical_list: D024243:HMGB1 Protein; D009414:Nerve Growth Factors; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579159:S100b protein, mouse