title: Fibrinogen as a damage-associated mitogenic signal for the renal fibroblast.
abstract: Fibroblast proliferation is central to the evolution of renal tubulointerstitial fibrosis. Using both in vivo and in vitro approaches, Sörensen et al. describe a role for fibrinogen as a cell-surface-receptor-mediated mitogen for renal fibroblasts. This interaction, likely to be initiated by injury and extravasation and to signal principally via Toll-like receptors, implicates fibrinogen in renal fibrosis beyond its textbook description as a scaffold precursor at the end of the coagulation cascade.
authors: Department of Physiology, School of Medicine, Trinity College Dublin, Dublin, Republic of Ireland. dochertn@tcd.ie
authors: Neil G
authors: NG
authors: Docherty
authors: Catherine
authors: C
authors: Godson
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D005340:Fibrinogen / Q000378:metabolism*; D005347:Fibroblasts / Q000378:metabolism*; D007684:Kidney Tubules / Q000378:metabolism*; D014517:Ureteral Obstruction / Q000378:metabolism*
chemical_list: C464794:fibrinogen Aalpha; D005340:Fibrinogen