title: The pattern of lymph node metastasis and the suitability of 7th UICC N stage in predicting prognosis of remnant gastric cancer.
abstract: BACKGROUND
  The original disease and previous operation usually cause abnormal lymphatic drainage of remnant gastric cancer (RGC). We analyzed metastatic lymph nodes (MLNs) of RGCs to explore the pattern of lymphatic metastasis and rational surgical treatment for RGC.
  
  
  METHODS
  Eighty-three RGC patients who underwent radical gastrectomy from July 1991 to July 2008 enrolled in this retrospective analysis.
  
  
  RESULTS
  Original disease, tumor size, Borrmann type, depth of invasion, and histological type were related to an increased risk of lymph node (LN) metastasis (P < 0.05). Multivariate logistic analysis revealed that tumor size and depth of invasion were independent predictive factors of LN metastasis (P < 0.05). In comparison with upper one-third gastric cancer, patients with RGC tended to have a lower incidence of perigastric LN metastasis and higher incidence of metastasis to the mesojejunum and lower mediastinal LNs. A high incidence of MLNs in the No. 14 and mesojejunum was found from the patients who had previously undergone Billroth II reconstruction, while patients after Billroth I reconstruction had higher No. 12 and No. 13 LN metastasis rates. Cut-point survival analysis demonstrated that the most appropriate cutoffs of MLNs were set at 0, 2, 6, and 9. Patients of 0, 1-2, 3-6, 7-9, or ≥10 MLNs presented with median survival time of 37, 35, 24, 13, and 9 month, respectively.
  
  
  CONCLUSIONS
  Preoperative diagnosis of depth of invasion and tumor size can help surgeons to evaluate LN metastasis. The 7th UICC N stage may be unsuitable and should be evaluated and improved in order to help surgeons rationally to estimate N stage of RGC.
authors: Department of Gastric Cancer Surgery, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
authors: Fangxuan
authors: F
authors: Li
authors: Rupeng
authors: R
authors: Zhang
authors: Han
authors: H
authors: Liang
authors: Hui
authors: H
authors: Liu
authors: Jichuan
authors: J
authors: Quan
authors: Jingzhu
authors: J
authors: Zhao
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D018365:Neoplasm, Residual / Q000473:pathology; D011379:Prognosis; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery