title: A novel adjuvant Ling Zhi-8 for cancer DNA vaccines.
abstract: DNA vaccines have a wide range of applications, with several potential advantages compared to other vaccine technologies for diseases. No DNA vaccine has yet been licensed in humans; however, a lot of effort has been made to enhance their potential as human vaccines and therapeutics. Finding an effective adjuvant is a strategy to improve the efficacy of DNA vaccines. We recently identified a fungal immunomodulatory protein Ling Zhi-8 (LZ-8) with stimulatory activity on dendritic cells (DCs) that significantly increases the efficacy of a cancer DNA vaccine in a preclinical tumor model, suggesting that LZ-8 may be a good candidate adjuvant for vaccine development. Here we discuss the possibility for applying LZ-8 to a cancer DNA vaccine for humans.
authors: Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan. clchu01@ntu.edu.tw
authors: Ching-Liang
authors: CL
authors: Chu
authors: Dz-Chi
authors: DzC
authors: Chen
authors: Chi-Chen
authors: CC
authors: Lin
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D000906:Antibodies / Q000097:blood; D001943:Breast Neoplasms / Q000276:immunology* / Q000628:therapy; D019496:Cancer Vaccines / Q000276:immunology*; D002986:Clinical Trials as Topic; D003713:Dendritic Cells / Q000276:immunology; D005260:Female; D005656:Fungal Proteins / Q000276:immunology*; D006801:Humans; D056747:Immunomodulation; D051379:Mice; D010051:Ovarian Neoplasms / Q000276:immunology* / Q000628:therapy; D013601:T-Lymphocytes / Q000276:immunology; D019444:Vaccines, DNA / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D000906:Antibodies; D019496:Cancer Vaccines; D005656:Fungal Proteins; D019444:Vaccines, DNA; C061148:LZ-8 protein, Ganoderma lucidum