title: Striatal dopamine transporter binding for predicting the development of delayed neuropsychological sequelae in suicide attempters by carbon monoxide poisoning: A SPECT study.
abstract: Carbon monoxide poisoning (COP) after charcoal burning results in delayed neuropsychological sequelae (DNS), which show clinical resemblance to Parkinson's disease, without adequate predictors at present. This study examined the role of dopamine transporter (DAT) binding for the prediction of DNS. Twenty-seven suicide attempters with COP were recruited. Seven of them developed DNS, while the remainder did not. The striatal DAT binding was measured by single photon emission computed tomography with (99m)Tc-TRODAT. The specific uptake ratio was derived based on a ratio equilibrium model. Using a logistic regression model, multiple clinical variables were examined as potential predictors for DNS. COP patients with DNS had a lower binding on left striatal DAT binding than patients without DNS. Logistic regression analysis showed that a combination of initial loss of consciousness and lower left striatal DAT binding predicted the development of DNS. Our data indicate that the left striatal DAT binding could help to predict the development of DNS. This finding not only demonstrates the feasibility of brain imaging techniques for predicting the development of DNS but will also help clinicians to improve the quality of care for COP patients.
authors: Department of Psychiatry, Taipei Veterans General Hospital Yuanshan Branch, Yilan, Taiwan.
authors: Kai-Chun
authors: KC
authors: Yang
authors: Department of Psychiatry, Taipei Veterans General Hospital & National Yang Ming University, Taipei, Taiwan.
authors: Hsiao-Lun
authors: HL
authors: Ku
authors: Department of Psychiatry, Taipei Veterans General Hospital & National Yang Ming University, Taipei, Taiwan.
authors: Chia-Liang
authors: CL
authors: Wu
authors: Department of Nuclear Medicine, Taipei Veterans General Hospital & National Yang Ming University, Taipei, Taiwan.
authors: Shyh-Jen
authors: SJ
authors: Wang
authors: Department of Toxicology, Taipei Veterans General Hospital & National Yang Ming University, Taipei, Taiwan.
authors: Chen-Chang
authors: CC
authors: Yang
authors: Department of Toxicology, Taipei Veterans General Hospital & National Yang Ming University, Taipei, Taiwan.
authors: Jou-Fang
authors: JF
authors: Deng
authors: Department of Health, Taiwan Suicide Prevention Center, Executive Yuan, Taipei, Taiwan; Department of Psychiatry, College of Medicine, National Taiwan University and Hospital, Taipei, Taiwan.
authors: Ming-Been
authors: MB
authors: Lee
authors: Department of Psychiatry, Taipei Veterans General Hospital & National Yang Ming University, Taipei, Taiwan; Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan. Electronic address: c520608@ms64.hinet.net.
authors: Yuan-Hwa
authors: YH
authors: Chou
mesh_terms: D000293:Adolescent; D000328:Adult; D002249:Carbon Monoxide Poisoning / Q000150:complications / Q000473:pathology / Q000523:psychology; D003072:Cognition Disorders / Q000139:chemically induced / Q000473:pathology*; D003342:Corpus Striatum / Q000000981:diagnostic imaging* / Q000378:metabolism; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008609:Mental Status Schedule; D009483:Neuropsychological Tests; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics; D011485:Protein Binding / Q000502:physiology; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D013406:Suicide, Attempted; D015899:Tomography, Emission-Computed, Single-Photon; D014326:Tropanes / Q000493:pharmacokinetics; D055815:Young Adult
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D014326:Tropanes; C104196:technetium Tc 99m TRODAT-1