title: Fibroblast growth factor 23 and the bone-vascular axis: lessons learned from animal studies.
abstract: Calcification of arteries and cardiac valves is observed commonly in dialysis patients and represents a major determinant of the heightened cardiovascular risk observed during chronic kidney disease (CKD) progression. Recent advances from clinical and basic science studies suggest that vascular calcification should be considered a systemic disease in which pathologic processes occurring in the bone and kidney contribute to calcium deposition in the vasculature. Among the factors potentially involved in the vascular-bone axis dysregulation associated with CKD, there now is increasing interest in the role of the phosphaturic hormone fibroblast growth factor 23 (FGF-23). Increased FGF-23 plasma levels are observed with a decrease in kidney function and predict the risk of future cardiovascular mortality. However, clinical data are still unclear about whether a direct pathogenetic effect of FGF-23 on vascular/kidney/bone health exists. In the last few years, a series of basic science studies, performed using engineered mice, have contributed important pathophysiologic information about FGF-23 activities. This review summarizes findings from these studies and discusses the potential role of FGF-23 during the pathologic interplay between kidney, vessels, and bone in CKD.
authors: Clinica Cardiologica, Dipartimento di Scienze Cardiologiche, Toraciche e Vascolari, Treviso, Italy.
authors: Giacomo
authors: G
authors: Zoppellaro
authors: Elisabetta
authors: E
authors: Faggin
authors: Massimo
authors: M
authors: Puato
authors: Paolo
authors: P
authors: Pauletto
authors: Marcello
authors: M
authors: Rattazzi
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000378:metabolism*; D001842:Bone and Bones / Q000378:metabolism*; D002908:Chronic Disease; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000502:physiology*; D006801:Humans; D007674:Kidney Diseases / Q000150:complications* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D061205:Vascular Calcification / Q000209:etiology*
chemical_list: C000717427:FGF23 protein, human; C000717428:Fgf23 protein, mouse; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23