title: Micelles from amphiphilic block copolyphosphates for drug delivery.
abstract: Amphiphilic block copolyphosphates (PEP-b-PIPPs) are synthesized by two-step ROP of cyclic phosphate monomers with different pedant groups. They can spontaneously self-assemble into approximately spherical micelles ranging in size between 89 and 198 nm in water. A typical hydrophobic anti-cancer drug DOX is encapsulated into the micelles. The release rate of DOX slows down with increasing hydrophobic block length of PIPP. DOX-loaded micelles are investigated for the proliferation inhibition of Hela cells and the DOX dose required for 50% cellular growth inhibition is found to be 0.8 µg mL(-1). It is demonstrated that PEP-b-PIPP micelles can be used as a safe and promising drug delivery system.
authors: School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai, China.
authors: Xiang
authors: X
authors: Zhai
authors: Wei
authors: W
authors: Huang
authors: Jinyao
authors: J
authors: Liu
authors: Yan
authors: Y
authors: Pang
authors: Xinyuan
authors: X
authors: Zhu
authors: Yongfeng
authors: Y
authors: Zhou
authors: Deyue
authors: D
authors: Yan
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D007211:Indoles / Q000032:analysis; D020128:Inhibitory Concentration 50; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D058105:Polymerization; D011122:Polyphosphates / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D013050:Spectrometry, Fluorescence
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D007211:Indoles; D008823:Micelles; D011122:Polyphosphates; D011092:Polyethylene Glycols; C007293:DAPI; D004317:Doxorubicin