title: Monitoring radiographic brain tumor progression.
abstract: Determining radiographic progression in primary malignant brain tumors has posed a significant challenge to the neuroncology community. Glioblastoma multiforme (GBM, WHO Grade IV) through its inherent heterogeneous enhancement, growth patterns, and irregular nature has been difficult to assess for progression. Our ability to detect tumor progression radiographically remains inadequate. Despite the advanced imaging techniques, detecting tumor progression continues to be a clinical challenge. Here we review the different criteria used to detect tumor progression, and highlight the inherent challenges with detection of progression.
authors: Division of Neurosurgery, Duke University Medical Center, Box 3807, Durham, NC 27710, USA. ankit.mehta@duke.edu
authors: Ankit I
authors: AI
authors: Mehta
authors: Charles W
authors: CW
authors: Kanaly
authors: Allan H
authors: AH
authors: Friedman
authors: Darell D
authors: DD
authors: Bigner
authors: John H
authors: JH
authors: Sampson
mesh_terms: D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D018450:Disease Progression; D005909:Glioblastoma / Q000000981:diagnostic imaging*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D011856:Radiographic Image Enhancement