title: Correlation between TCRCalpha -560 C/T polymorphism and the clinical presentation of Uygur IgA nephropathy patients in XinJiang.
abstract: OBJECTIVE
  To investigate the relationship between T cell receptor alpha chain constant gene (TCRCalpha) -560 C/T polymorphism and the clinical presentation of Uygur IgA Nephropathy patients in XinJiang.
  
  
  METHODS
  TCRCalpha -560 C/T genotypes were determined by PCR-RFLP in 300 Chinese Uygur IgAN patients and 600 healthy Chinese Uygur control subjects. All subjects were classified, based on their genotype, into TT, CT and CC groups and their corresponding clinical presentation was analyzed.
  
  
  RESULTS
  No significant difference was observed in the frequency of CC/CT/TT genotypes in patients and control subjects (chi2 = 0.904, P = 0.636). However, the incidence of intermittent microscopic hematuria and proteinuria is significantly higher in patients with CT genotype than CC and TT genotypes (chi2 = 33.978, P < 0.05).
  
  
  CONCLUSIONS
  TCRCalpha-560 C/T gene polymerphism may be associated with the occurrence of intermittent microscopic hematuria and proteinuria in Chinese Uygur IgAN patients.
authors: Department of Nephrology, Tongji Medical College Affiliated Hospital of Huazhong University of Science and Technology, Wuhan 430074, China.
authors: Chen
authors: C
authors: Lu
authors: Kaichun
authors: K
authors: Zhu
authors: Hongjuan
authors: H
authors: Zhao
authors: Jiani
authors: J
authors: Ji
authors: Ge
authors: G
authors: Mu
authors: Weili
authors: W
authors: Liu
authors: Gang
authors: G
authors: Xu
authors: Xiaocheng
authors: X
authors: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D019673:Genes, T-Cell Receptor alpha / Q000235:genetics*; D005838:Genotype; D005922:Glomerulonephritis, IGA / Q000235:genetics* / Q000276:immunology; D006417:Hematuria / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011507:Proteinuria / Q000235:genetics; D013223:Statistics as Topic / Q000379:methods; D055815:Young Adult