title: Challenges and opportunities for structural DNA nanotechnology.
abstract: DNA molecules have been used to build a variety of nanoscale structures and devices over the past 30 years, and potential applications have begun to emerge. But the development of more advanced structures and applications will require a number of issues to be addressed, the most significant of which are the high cost of DNA and the high error rate of self-assembly. Here we examine the technical challenges in the field of structural DNA nanotechnology and outline some of the promising applications that could be developed if these hurdles can be overcome. In particular, we highlight the potential use of DNA nanostructures in molecular and cellular biophysics, as biomimetic systems, in energy transfer and photonics, and in diagnostics and therapeutics for human health.
authors: Center for Single Molecule Biophysics, The Biodesign Institute, Arizona State University, Tempe, USA.
authors: Andre V
authors: AV
authors: Pinheiro
authors: Dongran
authors: D
authors: Han
authors: William M
authors: WM
authors: Shih
authors: Hao
authors: H
authors: Yan
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000191:economics / Q000379:methods*; D009690:Nucleic Acid Conformation
chemical_list: D004247:DNA