title: Maintained functionality of an implantable radiotelemetric blood pressure and heart rate sensor after magnetic resonance imaging in rats.
abstract: Radiotelemetric sensors for in vivo assessment of blood pressure and heart rate are widely used in animal research. MRI with implanted sensors is regarded as contraindicated as transmitter malfunction and injury of the animal may be caused. Moreover, artefacts are expected to compromise image evaluation. In vitro, the function of a radiotelemetric sensor (TA11PA-C10, Data Sciences International) after exposure to MRI up to 9.4 T was assessed. The magnetic force of the electromagnetic field on the sensor as well as radiofrequency (RF)-induced sensor heating was analysed. Finally, MRI with an implanted sensor was performed in a rat. Imaging artefacts were analysed at 3.0 and 9.4 T ex vivo and in vivo. Transmitted 24 h blood pressure and heart rate were compared before and after MRI to verify the integrity of the telemetric sensor. The function of the sensor was not altered by MRI up to 9.4 T. The maximum force exerted on the sensor was 273 ± 50 mN. RF-induced heating was ruled out. Artefacts impeded the assessment of the abdomen and thorax in a dead rat, but not of the head and neck. MRI with implanted radiotelemetric sensors is feasible in principal. The tested sensor maintains functionality up to 9.4 T. Artefacts hampered abdominal and throacic imaging in rats, while assessment of the head and neck is possible.
authors: Department of Neuroradiology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
authors: I
authors: I
authors: Nölte
authors: S
authors: S
authors: Gorbey
authors: H
authors: H
authors: Boll
authors: G
authors: G
authors: Figueiredo
authors: C
authors: C
authors: Groden
authors: B
authors: B
authors: Lemmer
authors: M A
authors: MA
authors: Brockmann
mesh_terms: D000818:Animals; D016477:Artifacts; D001794:Blood Pressure / Q000502:physiology*; D001795:Blood Pressure Determination / Q000295:instrumentation*; D002940:Circadian Rhythm; D003971:Diastole / Q000502:physiology; D006339:Heart Rate / Q000502:physiology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D019736:Prostheses and Implants; D011846:Radio Waves; D051381:Rats; D017208:Rats, Wistar; D013599:Systole / Q000502:physiology; D013686:Telemetry / Q000295:instrumentation*