title: Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese.
abstract: BACKGROUND
  Several novel susceptibility loci for type 2 diabetes have been identified through genome-wide association studies (GWAS) for type 2 diabetes or quantitative traits related to glucose metabolism in European populations. To investigate the association of the 13 new European GWAS-derived susceptibility loci with type 2 diabetes in the Japanese population, we conducted a replication study using 3 independent Japanese case-control studies.
  
  
  RESULTS
  We examined the association of single nucleotide polymorphisms (SNPs) within 13 loci (MTNR1B, GCK, IRS1, PROX1, BCL11A, ZBED3, KLF14, TP53INP1, KCNQ1, CENTD2, HMGA2, ZFAND6 and PRC1) with type 2 diabetes using 4,964 participants (2,839 cases and 2,125 controls) from 3 independent Japanese samples. The association of each SNP with type 2 diabetes was analyzed by logistic regression analysis. Further, we performed combined meta-analyses for the 3 studies and previously performed Japanese GWAS data (4,470 cases vs. 3,071 controls). The meta-analysis revealed that rs2943641 in the IRS1 locus was significantly associated with type 2 diabetes, (P = 0.0034, OR = 1.15 95% confidence interval; 1.05-1.26) and 3 SNPs, rs10930963 in the MTNR1B locus, rs972283 in the KLF14 locus, and rs231362 in the KCNQ1 locus, had nominal association with type 2 diabetes in the present Japanese samples (P<0.05).
  
  
  CONCLUSIONS
  These results indicate that IRS1 locus may be common locus for type 2 diabetes across different ethnicities.
authors: Laboratory for Endocrinology and Metabolism, RIKEN Center for Genomic Medicine, Yokohama, Kanagawa, Japan.
authors: Toshihiko
authors: T
authors: Ohshige
authors: Minoru
authors: M
authors: Iwata
authors: Shintaro
authors: S
authors: Omori
authors: Yasushi
authors: Y
authors: Tanaka
authors: Hiroshi
authors: H
authors: Hirose
authors: Kohei
authors: K
authors: Kaku
authors: Hiroshi
authors: H
authors: Maegawa
authors: Hirotaka
authors: H
authors: Watada
authors: Atsunori
authors: A
authors: Kashiwagi
authors: Ryuzo
authors: R
authors: Kawamori
authors: Kazuyuki
authors: K
authors: Tobe
authors: Takashi
authors: T
authors: Kadowaki
authors: Yusuke
authors: Y
authors: Nakamura
authors: Shiro
authors: S
authors: Maeda
mesh_terms: D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D007564:Japan / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics*