title: Pralidoxime in organophosphorus poisoning.
abstract: BACKGROUND
  Pralidoxime are enzyme reactivator that are known to reactivate the phosphorylated acetylcholinesterase by binding to the organophosphorus molecule. The use of oximes in acute organophosphorus poisoning has been a controversial subjects for over two decades. This study was conducted with the objective to find out the estimation of serum cholinesterase and use of pralidoxime in organophosphorus poisoning.
  
  
  METHODS
  A prospective analysis of all organophosphorus poisoning cases presented at the Emergency Department, Tribhuvan University Teaching Hospital for seven months was done.
  
  
  RESULTS
  Out of 26 cases about 60% of poisoning cases were monitored for pseudocholinesterase level. About 50% of them had pseudocholinesterase level within normal limit and 20% had less than 10% of normal value. Only 33% cases with pseudocholinesterase level less than 10% were treated with pralidoxime.
  
  
  CONCLUSIONS
  The initial dose of Pralidoxime used was 1 gm followed by maintenance dose of 500mg 6 hourly, the doses prescribed were less than WHO recommended doses.
authors: Department of Clinical Pharmacology, Institute of Medicine, Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal. simkhadanabaraj@hotmail.com
authors: N R
authors: NR
authors: Simkhada
authors: K K
authors: KK
authors: Kafle
authors: P N
authors: PN
authors: Prasad
mesh_terms: D002801:Cholinesterase Reactivators / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D062025:Organophosphate Poisoning; D011220:Pralidoxime Compounds / Q000627:therapeutic use*; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D002801:Cholinesterase Reactivators; D011220:Pralidoxime Compounds; C028797:pralidoxime