title: Synthesis and antifungal activity of novel sulfone derivatives containing 1,3,4-oxadiazole moieties.
abstract: A series of new sulfone compounds containing 1,3,4-oxadiazole moieties were synthesized. The structures of these compounds were confirmed by spectroscopic data (IR, ¹H- and ¹³C-NMR) and elemental analyses. Antifungal tests indicated that all the title compounds exhibited good antifungal activities against eight kinds of plant pathogenic fungi, and some showed superiority over the commercial fungicide hymexazol. Among them, compounds 5d, 5e, 5f, and 5i showed prominent activity against B. cinerea, with determined EC₅₀ values of 5.21 μg/mL, 8.25 µg/mL, 8.03 µg/mL, and 21.00 µg/mL, respectively. The present work demonstrates that sulfone derivatives such as 5d containing a 1,3,4-oxadiazole moiety can be used as possible lead compounds for the development of potential agrochemicals.
authors: Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025, China. xuweiming2009@163.com
authors: Weiming
authors: W
authors: Xu
authors: Jiang
authors: J
authors: He
authors: Ming
authors: M
authors: He
authors: Feifei
authors: F
authors: Han
authors: Xuehai
authors: X
authors: Chen
authors: Zhaoxi
authors: Z
authors: Pan
authors: Jian
authors: J
authors: Wang
authors: Maoguo
authors: M
authors: Tong
mesh_terms: D000383:Agriculture / Q000379:methods; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D018556:Crops, Agricultural / Q000382:microbiology; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010069:Oxadiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D010935:Plant Diseases / Q000382:microbiology; D013450:Sulfones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D010069:Oxadiazoles; D013450:Sulfones