title: Effects of sedation with acepromazine maleate and buprenorphine hydrochloride on femoral artery blood flow in healthy dogs.
abstract: The purpose of this study was to qualify and quantify the femoral artery blood flow by duplex Doppler ultrasonography (DDU) in healthy dogs, before and after the administration of a combination of acepromazine maleate and buprenorphine hydrochloride (ACP-BPN). Seven healthy adult mongrel dogs and three adult beagles were used. Heart rate, arterial blood pressure and measurement of femoral artery blood flow by DDU were also recorded. The DDU measurements were: femoral artery diameter (FAD), peak systolic velocity (PSV), early retrograde (EDV) and end diastolic velocities (EnDV), mean velocity (BMV), pulsatility index (PI), flow velocity integral (FVI) and femoral blood flow (FBF). After 30 min, combination ACP-BPN was administered intramuscularly, and all the measurements were recorded again. The ACP-BPN protocol induced a significant decrease in systolic, mean, and diastolic arterial blood pressure, and heart rate. A significant increase in peak systolic velocity and integral flow velocity integral of the femoral blood were obtained. The Doppler spectra of the blood flow in the femoral artery revealed a spectral dispersion pattern after ACP-BPN administration in all the dogs. These results demonstrate that despite quantitative and qualitative changes, the overall femoral blood flow (FBF) is not significantly modified.
authors: Department of Veterinary Medicine, Universidade Federal de Lavras, Campus Universitário, Caixa Postal 3037, 37200-000 Lavras, MG, Brazil. nogueirarb@uol.com.br
authors: R B
authors: RB
authors: Nogueira
authors: M J
authors: MJ
authors: Fernández del Palacio
authors: J T
authors: JT
authors: López
authors: R M
authors: RM
authors: Resende
mesh_terms: D000075:Acepromazine / Q000008:administration & dosage / Q000494:pharmacology*; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects / Q000662:veterinary*; D002047:Buprenorphine / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs / Q000502:physiology*; D018492:Dopamine Antagonists / Q000008:administration & dosage / Q000494:pharmacology; D004359:Drug Therapy, Combination; D005263:Femoral Artery / Q000187:drug effects* / Q000502:physiology; D018616:Ultrasonography, Doppler, Duplex / Q000662:veterinary
chemical_list: D000701:Analgesics, Opioid; D018492:Dopamine Antagonists; D002047:Buprenorphine; D000075:Acepromazine