title: Pyridoxine-derived bicyclic aminopyridinol antioxidants: synthesis and their antioxidant activities.
abstract: A few facile synthetic pathways for bicyclic aminopyridinol antioxidants are presented. Attachment of a long alkyl chain to the bicyclic pyridinol scaffold was established using ester linkage. Non-substituted pyrrolopyridinols and 1,3-oxazine-fused pyridinols were also synthesized as novel antioxidant scaffolds. Antioxidant activities were measured by a radical clock method and new compounds prepared are comparable to the best bicyclic aminopyridinol antioxidants.
authors: Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, USA.
authors: Tae-gyu
authors: TG
authors: Nam
authors: Jin-Mo
authors: JM
authors: Ku
authors: Christopher L
authors: CL
authors: Rector
authors: Hoyoung
authors: H
authors: Choi
authors: Ned A
authors: NA
authors: Porter
authors: Byeong-Seon
authors: BS
authors: Jeong
mesh_terms: D000631:Aminopyridines / Q000138:chemical synthesis / Q000737:chemistry*; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D011736:Pyridoxine / Q000737:chemistry*
chemical_list: D000631:Aminopyridines; D000975:Antioxidants; D019086:Bridged Bicyclo Compounds, Heterocyclic; D011736:Pyridoxine