title: [Elements of metabolic control in children with type 1 diabetes before and after introduction to insulin analogues].
abstract: BACKGROUND
  Diabetes mellitus type 1 (T1DM) in children is characterized by unstable course. A significant number of studies shows that introduction to insulin analogues treatment aims towards better control of the disease.
  
  
  OBJECTIVE
  The assessment of metabolic control in children with T1DM that were introduced to insulin analogue treatment after many years of treatment with classic (human) insulin.
  
  
  METHODS
  The study included 59 patients 2-19 years old (12.9 +/- 3.8) with T1DM, transferred from treatment with human insulin to insulin analogues treatment. Data were obtained directly from patients and their parents, as well as from medical records.
  
  
  RESULTS
  The introduction to insulin analogues treatment, leads to a decrease in the value of glycolized haemoglobin (HbA1c) after 6 months (9.27 +/- 1.68% vs 8.63 +/- 1:26%, p=0.06). Average daily dose of insulin expressed per IU/kg of classic and insulin analogue (1.04 +/- 0.38 vs 1.03 +/- 0.30; p>0.05), remained almost the same. In 39 examinees (66.1%), 6 months before the introduction to insulin analogue treatment, severe hypoglicemia was registered and 6 months after the introduction to insulin analogue treatment it appeared in only two examinees (3.4%) (p<0.001). Ketoacidosis, 6 months before introduction to insulin analogues treatment, appeared in 16 examinees (27.1%), while 6 months after it was not registered (p<0.001).
  
  
  CONCLUSIONS
  The use of insulin analogue treatment in childhood provides adequate metabolic control and substantially reduces the risk of acute complications (severe hypoglicemia, ketoacidosis).
authors: Liiljana
authors: L
authors: Baloš
authors: Silvija
authors: S
authors: Sajić
authors: Vera
authors: V
authors: Zdravković
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D061385:Insulins / Q000627:therapeutic use*; D008297:Male; D055815:Young Adult
chemical_list: D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D061385:Insulins