title: 1-Phenylisoquinoline larvicidal activity against Culex quinquefasciatus.
abstract: The larvicidal potential of several dopamine 1-phenylisoquinoline derivatives against Culex quinquefasciatus third instar larvae was investigated in a rational search for insecticides. The results showed that these isoquinolines presented moderate larvicidal activity, that the presence of a substituent is needed on carbon 1 for such activity to be presented and that it may be possible to develop novel insecticidal compounds having potential use in controlling insects by appropriate structural modification of 1-phenylisoquinolines. This article presents a possible structure-larvicidal activity relationship for isoquinolinic compounds.
authors: Departamento de Química, Facultad de Ciencias , Universidad Nacional de Colombia, Bogotá, Colombia. arquevedop@unal.edu.co
authors: Rodolfo
authors: R
authors: Quevedo
authors: Edwin
authors: E
authors: Baquero
authors: Martha L
authors: ML
authors: Quiñones
mesh_terms: D000818:Animals; D003465:Culex / Q000187:drug effects* / Q000254:growth & development; D007306:Insecticides / Q000737:chemistry / Q000494:pharmacology*; D007546:Isoquinolines / Q000737:chemistry / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D007306:Insecticides; D007546:Isoquinolines