title: PlantNATsDB: a comprehensive database of plant natural antisense transcripts.
abstract: Natural antisense transcripts (NATs), as one type of regulatory RNAs, occur prevalently in plant genomes and play significant roles in physiological and pathological processes. Although their important biological functions have been reported widely, a comprehensive database is lacking up to now. Consequently, we constructed a plant NAT database (PlantNATsDB) involving approximately 2 million NAT pairs in 69 plant species. GO annotation and high-throughput small RNA sequencing data currently available were integrated to investigate the biological function of NATs. PlantNATsDB provides various user-friendly web interfaces to facilitate the presentation of NATs and an integrated, graphical network browser to display the complex networks formed by different NATs. Moreover, a 'Gene Set Analysis' module based on GO annotation was designed to dig out the statistical significantly overrepresented GO categories from the specific NAT network. PlantNATsDB is currently the most comprehensive resource of NATs in the plant kingdom, which can serve as a reference database to investigate the regulatory function of NATs. The PlantNATsDB is freely available at http://bis.zju.edu.cn/pnatdb/.
authors: Department of Bioinformatics, State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.
authors: Dijun
authors: D
authors: Chen
authors: Chunhui
authors: C
authors: Yuan
authors: Jian
authors: J
authors: Zhang
authors: Zhao
authors: Z
authors: Zhang
authors: Lin
authors: L
authors: Bai
authors: Yijun
authors: Y
authors: Meng
authors: Ling-Ling
authors: LL
authors: Chen
authors: Ming
authors: M
authors: Chen
mesh_terms: D003196:Computer Graphics; D030561:Databases, Nucleic Acid; D053263:Gene Regulatory Networks; D020407:Internet; D016372:RNA, Antisense / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D018749:RNA, Plant / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D058727:RNA, Small Untranslated / Q000737:chemistry; D014584:User-Computer Interface
chemical_list: D016372:RNA, Antisense; D018749:RNA, Plant; D058727:RNA, Small Untranslated