title: Drosophila microbiome modulates host developmental and metabolic homeostasis via insulin signaling.
abstract: The symbiotic microbiota profoundly affect many aspects of host physiology; however, the molecular mechanisms underlying host-microbe cross-talk are largely unknown. Here, we show that the pyrroloquinoline quinone-dependent alcohol dehydrogenase (PQQ-ADH) activity of a commensal bacterium, Acetobacter pomorum, modulates insulin/insulin-like growth factor signaling (IIS) in Drosophila to regulate host homeostatic programs controlling developmental rate, body size, energy metabolism, and intestinal stem cell activity. Germ-free animals monoassociated with PQQ-ADH mutant bacteria displayed severe deregulation of developmental and metabolic homeostasis. Importantly, these defects were reversed by enhancing host IIS or by supplementing the diet with acetic acid, the metabolic product of PQQ-ADH.
authors: School of Biological Science, Seoul National University and National Creative Research Initiative Center for Symbiosystem, Seoul 151-742, South Korea.
authors: Seung Chul
authors: SC
authors: Shin
authors: Sung-Hee
authors: SH
authors: Kim
authors: Hyejin
authors: H
authors: You
authors: Boram
authors: B
authors: Kim
authors: Aeri C
authors: AC
authors: Kim
authors: Kyung-Ah
authors: KA
authors: Lee
authors: Joo-Heon
authors: JH
authors: Yoon
authors: Ji-Hwan
authors: JH
authors: Ryu
authors: Won-Jae
authors: WJ
authors: Lee
mesh_terms: D000091:Acetobacter / Q000235:genetics / Q000502:physiology*; D000818:Animals; D049628:Body Size / Q000235:genetics; D002237:Carbohydrate Dehydrogenases / Q000378:metabolism*; D004330:Drosophila / Q000254:growth & development / Q000382:microbiology*; D005260:Female; D006706:Homeostasis; D007328:Insulin / Q000378:metabolism*; D007422:Intestines / Q000382:microbiology; D054892:Metagenome / Q000502:physiology*; D015398:Signal Transduction; D013002:Somatomedins / Q000378:metabolism
chemical_list: D007328:Insulin; D013002:Somatomedins; D002237:Carbohydrate Dehydrogenases; C082601:aldose dehydrogenase (pyrroloquinoline-quinone)