title: Exploiting the acylating nature of the imide-Ugi intermediate: a straightforward synthesis of tetrahydro-1,4-benzodiazepin-2-ones.
abstract: We describe a simple and novel protocol for the synthesis of tetrahydro-1,4-benzodiazepin-2-ones with three points of diversity, exploiting the acylating properties of the recently rediscovered Ugi-imide. The final compounds can be easily prepared in three synthetic steps using a multicomponent reaction, a Staudinger reduction, and an acylative protocol, with good to excellent yields for each synthetic step.
authors: Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Università degli Studi del Piemonte Orientale A. Avogadro, Via Bovio 6, 28100 Novara, Italy.
authors: Riccardo
authors: R
authors: Mossetti
authors: Dèsirèe
authors: D
authors: Saggiorato
authors: Gian Cesare
authors: GC
authors: Tron
mesh_terms: D000215:Acylation; D019380:Anti-HIV Agents / Q000138:chemical synthesis; D000970:Antineoplastic Agents / Q000138:chemical synthesis; D001570:Benzodiazepinones / Q000138:chemical synthesis*; D060326:Chemistry Techniques, Synthetic; D006801:Humans; D007094:Imides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D001570:Benzodiazepinones; D007094:Imides