title: Tumor bombesin analog loaded long-circulating and pH-sensitive liposomes as tool for tumor identification.
abstract: Long-circulating and pH-sensitive liposomes trapping (99m)Tc-HYNIC-βAla-bombesin((7-14)) (aSpHL-(99m)Tc-BBN((7-14))) were successfully prepared. Biodistribution studies and scintigraphic images were performed in Ehrlich tumor-bearing Swiss mice. This system showed high accumulation in tumor tissue with high tumor-to-muscle ratio. Therefore, aSpHL-(99m)Tc-BBN((7-14)) could be considered as a potential agent for tumor diagnosis.
authors: Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, 31279-901 Belo Horizonte, Minas Gerais, Brazil.
authors: André Luís Branco
authors: AL
authors: de Barros
authors: Luciene das Graças
authors: Ld
authors: Mota
authors: Daniel Crístian Ferreira
authors: DC
authors: Soares
authors: Marina Melo Antunes
authors: MM
authors: Coelho
authors: Mônica Cristina
authors: MC
authors: Oliveira
authors: Valbert Nascimento
authors: VN
authors: Cardoso
mesh_terms: D000818:Animals; D001839:Bombesin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D002286:Carcinoma, Ehrlich Tumor / Q000175:diagnosis; D006863:Hydrogen-Ion Concentration; D007553:Isotope Labeling; D008081:Liposomes / Q000737:chemistry*; D051379:Mice; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D013667:Technetium / Q000737:chemistry; D014018:Tissue Distribution
chemical_list: D008081:Liposomes; D019275:Radiopharmaceuticals; D013667:Technetium; D001839:Bombesin