title: Divergent synthetic approach to 6''-modified α-GalCer analogues.
abstract: A synthetic approach is presented for the synthesis of galacturonic acid and D-fucosyl modified KRN7000. The approach allows for late-stage functionalisation of both the sugar 6''-OH and the sphingosine amino groups, which enables convenient synthesis of promising 6''-modified KRN7000 analogues.
authors: Laboratory for Medicinal Chemistry (FFW), Faculty of Pharmaceutical Sciences, UGent, Harelbekestraat 72, B-9000 Gent, Belgium.
authors: Nora
authors: N
authors: Pauwels
authors: Sandrine
authors: S
authors: Aspeslagh
authors: Gerd
authors: G
authors: Vanhoenacker
authors: Koen
authors: K
authors: Sandra
authors: Esther D
authors: ED
authors: Yu
authors: Dirk M
authors: DM
authors: Zajonc
authors: Dirk
authors: D
authors: Elewaut
authors: Bruno
authors: B
authors: Linclau
authors: Serge
authors: S
authors: Van Calenbergh
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism; D005699:Galactosylceramides / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry; D006603:Hexuronic Acids / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry; D051379:Mice; D008968:Molecular Conformation; D013237:Stereoisomerism; D020349:Surface Plasmon Resonance
chemical_list: D016207:Cytokines; D005699:Galactosylceramides; D006603:Hexuronic Acids; C007819:galacturonic acid; C103873:KRN 7000