title: Regeneration of rodent small intestine tissue following implantation of scaffolds seeded with a novel source of smooth muscle cells.
abstract: OBJECTIVE
  To apply an organ regeneration platform technology of autologous smooth muscle cell/biomaterial combination products, previously demonstrated to be successful for urinary tissue regeneration, to the regeneration of the small intestine.
  
  
  METHODS
  Patch and tubular constructs were implanted in rodent small intestines and histologically evaluated over a time course for evidence of regeneration of the laminarly organized neo-mucosa and muscle layers.
  
  
  RESULTS
  Laminarly organized neo-mucosa and muscle layer bundles are demonstrated as early as 8 weeks postimplantation.
  
  
  CONCLUSIONS
  An organ regeneration technology platform of autologous smooth muscle cell/biomaterial combination products can be extended to the regeneration of the small intestine.
authors: Tengion Inc., 3929 Westpoint Boulevard, Suite G, Winston-Salem, NC 27103, USA. joydeep.basu@tengion.com
authors: Joydeep
authors: J
authors: Basu
authors: Kim L
authors: KL
authors: Mihalko
authors: Richard
authors: R
authors: Payne
authors: Elias
authors: E
authors: Rivera
authors: Toyin
authors: T
authors: Knight
authors: Christopher W
authors: CW
authors: Genheimer
authors: Kelly I
authors: KI
authors: Guthrie
authors: Namrata
authors: N
authors: Sangha
authors: Manuel J
authors: MJ
authors: Jayo
authors: Deepak
authors: D
authors: Jain
authors: Timothy A
authors: TA
authors: Bertram
authors: John W
authors: JW
authors: Ludlow
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D005260:Female; D005786:Gene Expression Regulation; D007421:Intestine, Small / Q000166:cytology / Q000502:physiology* / Q000601:surgery; D008297:Male; D032389:Myocytes, Smooth Muscle / Q000166:cytology* / Q000378:metabolism / Q000637:transplantation / Q000648:ultrastructure; D019919:Prosthesis Implantation; D051381:Rats; D011917:Rats, Inbred Lew; D012038:Regeneration / Q000502:physiology*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*