title: A simple dose regimen of artesunate and amodiaquine based on arm span- or age range for childhood falciparum malaria: a preliminary evaluation.
abstract: A dose regimen of artesunate and amodiaquine based on arm span- or age range (DRAAAS), derived from a study of 1674 children, was compared with standard dose regimen of the same drugs calculated according to body weight (SDRAA) in 68 malarious children. Children on DRAAAS received 0.8-1.0 of artesunate/kg and 0.9-1.2 times amodiaquine/kg compared with those receiving SDRAA. Parasite and fever clearance and fall in hematocrit in the first 3 days were similar; both regimens were well tolerated. DRAAAS is simple and is efficacious.
authors: Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan, Nigeria Institute for Medical Research Training, University of Ibadan, Ibadan, Nigeria. akinsowunmi@hotmail.com
authors: Akintunde
authors: A
authors: Sowunmi
authors: Ibukun A
authors: IA
authors: Akinrinola
authors: Grace O
authors: GO
authors: Gbotosho
authors: Titilope M
authors: TM
authors: Okuboyejo
authors: Christian T
authors: CT
authors: Happi
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D000655:Amodiaquine / Q000008:administration & dosage* / Q000627:therapeutic use; D000962:Antimalarials / Q000008:administration & dosage* / Q000627:therapeutic use; D019540:Area Under Curve; D001132:Arm; D037621:Artemisinins / Q000008:administration & dosage* / Q000627:therapeutic use; D000077332:Artesunate; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000175:diagnosis / Q000188:drug therapy* / Q000469:parasitology; D008297:Male; D010963:Plasmodium falciparum / Q000302:isolation & purification; D015397:Program Evaluation; D016896:Treatment Outcome
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D000655:Amodiaquine; D000077332:Artesunate