title: Limited influence of aspirin intake on mast cell activation in patients with food-dependent exercise-induced anaphylaxis: comparison using skin prick and histamine release tests.
abstract: Food-dependent exercise-induced anaphylaxis (FDEIA) is a severe systemic syndrome induced by physical exercise after ingesting causative food. Aspirin is a well-known trigger for anaphylaxis in patients with FDEIA. Possible mechanisms by which symptoms are aggravated by aspirin include enhanced antigen absorption and mast cell activation. The aim of this study was to determine whether aspirin intake has an influence on mast cell/basophil activation in patients with FDEIA. Provocation tests revealed that adding aspirin to the causative food challenge in 7 of 9 (77.8%) patients with FDEIA provoked symptoms. In most cases, pretreatment with aspirin did not enhance skin tests (71.4%) or histamine release tests (88.9%) with food allergen challenges. The study confirms that histamine release and skin prick tests can be adjunctive tools for diagnosing FDEIA. In addition, our results suggest that exacerbation of FDEIA symptoms by aspirin is not mediated by direct effects of aspirin on mast cell/basophil activation.
authors: Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kusunoki-cho, Chuo-ku, Japan. atsushi@med.kobe-u.ac.jp
authors: Atsushi
authors: A
authors: Fukunaga
authors: Hideki
authors: H
authors: Shimizu
authors: Mami
authors: M
authors: Tanaka
authors: Ayuko
authors: A
authors: Kikuzawa
authors: Mariko
authors: M
authors: Tsujimoto
authors: Akiko
authors: A
authors: Sekimukai
authors: Junji
authors: J
authors: Yamashita
authors: Tatsuya
authors: T
authors: Horikawa
authors: Chikako
authors: C
authors: Nishigori
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000707:Anaphylaxis / Q000175:diagnosis* / Q000276:immunology; D001241:Aspirin / Q000009:adverse effects*; D001491:Basophils / Q000187:drug effects / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D015444:Exercise; D005080:Exercise Test; D005260:Female; D005512:Food Hypersensitivity / Q000175:diagnosis* / Q000276:immunology; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D008297:Male; D008407:Mast Cells / Q000187:drug effects* / Q000276:immunology; D008875:Middle Aged; D011237:Predictive Value of Tests; D012307:Risk Factors; D012882:Skin Tests
chemical_list: D001241:Aspirin