title: Biochemical screening of fetal aneuploidies and neural tube defects by "double-test" in Croatia: a 10 years' experience.
abstract: The aim of the study is to investigate the efficiency of the second-trimester biochemical screening, with maternal serum alpha-fetoprotein (MS-AFP) and free beta-subunit of human chorionic gonadotropin (free beta-hCG), during the ten-year period. The study included 11,292 of pregnant women between the 15th and 18th gestational week, who underwent screening from November 1996 to December 2006. The risk for trisomy 21 and trisomy 18 were calculated by computer software, based on a model which generated the final risk for fetal aneuploidies from the pregnant woman's a priori age risk and the likelihood ratio of the distribution of the biochemical markers, according to the second-trimester gestation. With the cut-off value of the final risk > or = 1:250, the detection rate for trisomy 21 was 75% (21/28). In women less than or equal to 35, the detection was 57.1% (8/14) and 92.9% (13/14) in those over 35 years, respectively. The detection rate of trisomy 18 was 50% (2/4). The results confirmed that the implementation of double-test, as non-invasive screening for fetal aneuploidies, should be accepted as a complementary method of antenatal care.
authors: University of Zagreb, "Sestre milosrdnice" University Hospital Centre, Laboratory of Endocrinology, Clinic of Oncology and Nuclear Medicine, Zagreb, Croatia dubravka.tislaric.medenjak@kbcsm.hr
authors: Dubravka
authors: D
authors: Tislarić-Medenjak
authors: Vesna
authors: V
authors: Kosec
authors: Ivana
authors: I
authors: Tonković-Durisević
authors: Ivana
authors: I
authors: Zec
authors: Senka
authors: S
authors: Sabolović-Rudman
authors: Krunoslav
authors: K
authors: Kuna
authors: Radoslav
authors: R
authors: Herman
authors: Tomislav
authors: T
authors: Ivicević-Bakulić
authors: Hrvojka
authors: H
authors: Soljacić-Vranes
authors: Neven
authors: N
authors: Tuckar
authors: Dubravka
authors: D
authors: Muzinić
authors: Drazan
authors: D
authors: Butorac
authors: Ivan
authors: I
authors: Bolanca
authors: Andro
authors: A
authors: Kosec
authors: Feodora
authors: F
authors: Stipoljev
mesh_terms: D000293:Adolescent; D000328:Adult; D000782:Aneuploidy; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood*; D004314:Down Syndrome / Q000175:diagnosis; D005260:Female; D006801:Humans; D008875:Middle Aged; D009436:Neural Tube Defects / Q000175:diagnosis*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011296:Prenatal Diagnosis / Q000379:methods*; D000509:alpha-Fetoproteins / Q000032:analysis*
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human; D000509:alpha-Fetoproteins