title: Developments in virus-like particle-based vaccines for infectious diseases and cancer.
abstract: Virus-like particles hold great promise for the development of effective and affordable vaccines. Indeed, virus-like particles are suitable for presentation and efficient delivery of linear as well as conformational antigens to antigen-presenting cells. This will ultimately result in optimal B-cell activation and cross-presentation with both MHC class I and II molecules to prime CD4(+) T-helper as well as CD8(+) cytotoxic T cells. This article provides an update on the development and use of virus-like particles as vaccine approaches for infectious diseases and cancer.
authors: Molecular Biology and Viral Oncology, Department of Experimental Oncology, Istituto Nazionale Tumori Fond Pascale, Via Mariano Semmola 142, 80131 Napoli, Italy. irccsvir@unina.it
authors: Luigi
authors: L
authors: Buonaguro
authors: Maria
authors: M
authors: Tagliamonte
authors: Maria Lina
authors: ML
authors: Tornesello
authors: Franco M
authors: FM
authors: Buonaguro
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D019496:Cancer Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D002986:Clinical Trials as Topic; D000939:Epitopes / Q000276:immunology; D006801:Humans; D009369:Neoplasms / Q000517:prevention & control / Q000628:therapy; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000276:immunology; D022721:Vaccines, Virosome / Q000008:administration & dosage / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D014777:Virus Diseases / Q000517:prevention & control / Q000628:therapy; D014780:Viruses
chemical_list: D019496:Cancer Vaccines; D000939:Epitopes; D014614:Vaccines, Synthetic; D022721:Vaccines, Virosome; D014765:Viral Vaccines