title: Myasthenia gravis: two case reports and review of the literature.
abstract: OBJECTIVE
  Myasthenia gravis (MG) is an autoimmune neurologic disease that affects the postsynaptic portion of the neuromuscular junction. It represents a challenge for anesthesiologists due to the diversity of disease manifestations and possibility of postoperative respiratory complications. The objective of this study was to demonstrate the importance of adequate monitoring of the neuromuscular blockade (NMB) due to the multiple presentations of MG.
  
  
  BACKGROUND
  In this paper we report two cases of patients with MG. The first patient presented with the classical sensitivity to the neuromuscular blocker (NMB) and the second had a similar response to that of a normal patient. The literature review will be restricted to disease characteristics, while the description of its pathophysiology will focus on its reactions to NMB.
  
  
  CONCLUSIONS
  We suggest that, due to the multiple presentation and treatment of MG, neuromuscular transmission monitors are fundamental when using NMB.
authors: Universidade de São Paulo, SP, Brazil. analaurakauling@gmail.com
authors: Ana Laura Colle
authors: AL
authors: Kauling
authors: Maria Cristina Simões
authors: MC
authors: de Almeida
authors: Giovani de Figueiredo
authors: Gde F
authors: Locks
authors: Guilherme Muriano
authors: GM
authors: Brunharo
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D009157:Myasthenia Gravis; D019148:Neuromuscular Blockade; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage*
chemical_list: D009466:Neuromuscular Blocking Agents