title: Organs-on-a-chip: a focus on compartmentalized microdevices.
abstract: Advances in microengineering technologies have enabled a variety of insights into biomedical sciences that would not have been possible with conventional techniques. Engineering microenvironments that simulate in vivo organ systems may provide critical insight into the cellular basis for pathophysiologies, development, and homeostasis in various organs, while curtailing the high experimental costs and complexities associated with in vivo studies. In this article, we aim to survey recent attempts to extend tissue-engineered platforms toward simulating organ structure and function, and discuss the various approaches and technologies utilized in these systems. We specifically focus on microtechnologies that exploit phenomena associated with compartmentalization to create model culture systems that better represent the in vivo organ microenvironment.
authors: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
authors: Christopher
authors: C
authors: Moraes
authors: Geeta
authors: G
authors: Mehta
authors: Sasha Cai
authors: SC
authors: Lesher-Perez
authors: Shuichi
authors: S
authors: Takayama
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques / Q000295:instrumentation / Q000379:methods; D006801:Humans; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods*; D023822:Tissue Engineering / Q000295:instrumentation* / Q000379:methods*