title: Alkaloids and flavonoids as α(1)-adrenergic receptor antagonists.
abstract: Since the subtypes of α(1)-adrenergic receptor have been thoroughly determined, to date medicinal chemists raise their deliberation on how to conceive selective α(1)-adrenergic receptor antagonist with the minimal side effects. It needs to be well recognized that natural products can exist as a significant source of drug leads, thus portraying a consequential capacity in drug design and development. The current review article would like to present a comprehensive survey on natural products, mainly including alkaloids and flavonoids, which exhibit α(1)-adrenergic receptor antagonistic activities.
authors: Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan, Shandong 250012, China.
authors: W
authors: W
authors: Li
authors: L
authors: L
authors: Du
authors: M
authors: M
authors: Li
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000737:chemistry* / Q000494:pharmacology*; D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008956:Models, Chemical; D013329:Structure-Activity Relationship
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D000470:Alkaloids; D005419:Flavonoids