title: Comparison of sea snake (Hydrophiidae) neurotoxin to cobra (Naja) neurotoxin.
abstract: Both sea snakes and cobras have venoms containing postsynaptic neurotoxins. Comparison of the primary structures indicates many similarities, especially the positions of the four disulfide bonds. However, detailed examination reveals differences in several amino acid residues. Amino acid sequences of sea snake neurotoxins were determined, and then compared to cobra neurotoxins by computer modeling. This allowed for easy comparison of the similarities and differences between the two types of postsynaptic neurotoxins. Comparison of computer models for the toxins of sea snakes and cobra will reveal the three dimensional difference of the toxins much clearer than the amino acid sequence alone.
authors: Department of Microbiology, Faculty of Pharmacy, Meijo University, Nagoya 468-8503, Japan. ykomori@ccmfs.meijo-u.ac.jp
authors: Yumiko
authors: Y
authors: Komori
authors: Masaya
authors: M
authors: Nagamizu
authors: Kei-Ichi
authors: K
authors: Uchiya
authors: Toshiaki
authors: T
authors: Nikai
authors: Anthony T
authors: AT
authors: Tu
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003039:Cobra Neurotoxin Proteins; D004546:Elapid Venoms / Q000737:chemistry; D017815:Elapidae; D008969:Molecular Sequence Data; D009498:Neurotoxins / Q000737:chemistry; D014118:Toxins, Biological
chemical_list: D003039:Cobra Neurotoxin Proteins; D004546:Elapid Venoms; D009498:Neurotoxins; D014118:Toxins, Biological