title: The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use.
abstract: Interleukin-15 (IL-15) is a pleiotropic cytokine with a broad range of biological functions in many diverse cell types. It plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems. This review provides an overview of the mechanisms by which IL-15 modulates the host response to infectious agents and its utility as a cytokine adjuvant in vaccines against infectious pathogens.
authors: Veterans Affairs Medical Center, Washington, DC 20422, USA.
authors: Pin-Yu
authors: PY
authors: Perera
authors: Jack H
authors: JH
authors: Lichy
authors: Thomas A
authors: TA
authors: Waldmann
authors: Liyanage P
authors: LP
authors: Perera
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000818:Animals; D003713:Dendritic Cells / Q000276:immunology; D054884:Host-Pathogen Interactions; D006801:Humans; D007109:Immunity; D007249:Inflammation / Q000276:immunology*; D019409:Interleukin-15 / Q000276:immunology* / Q000627:therapeutic use*; D007694:Killer Cells, Natural / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D008407:Mast Cells / Q000276:immunology; D009000:Monocytes / Q000276:immunology; D009169:Mycobacterium tuberculosis / Q000276:immunology / Q000472:pathogenicity; D009504:Neutrophils / Q000276:immunology; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology; D014376:Tuberculosis / Q000276:immunology / Q000382:microbiology; D014777:Virus Diseases / Q000276:immunology / Q000821:virology; D014780:Viruses / Q000276:immunology / Q000472:pathogenicity
chemical_list: D000276:Adjuvants, Immunologic; D019409:Interleukin-15