title: Electrophysiological studies in newly onset type 2 diabetes without visible vascular retinopathy.
abstract: The purpose of this study was to investigate the early alterations of retinal function, assessed with electrophysiology, in newly onset type 2 diabetes patients without vascular retinopathy. Seventeen patients with newly diagnosed type 2 diabetes (duration 7±3 months), without any vascular retinopathy in fundus photographs, were examined with full-field electroretinogram (ERG) and multifocal ERG (mfERG). The results were compared with those of age-matched subjects without diabetes. In the dark-adapted full-field ERG, the a-wave and the 30-Hz flicker implicit times were delayed in diabetes patients compared to controls, P=0.001 and P=0.020. In the first-order kernel of the mfERG, the first positive wave, P1, was delayed in all areas measured. The electrophysiological examinations demonstrate early alterations of retinal function characterised by a delayed a-wave implicit time in the dark-adapted full-field ERG, representing the rod signalling, and alterations in the multifocal ERG reflecting cone and/or postreceptoral function.
authors: Department of Ophthalmology, Helsingborg Hospital, Lund University, 251 87, Helsingborg, Sweden. maria.tyrberg@med.lu.se
authors: M
authors: M
authors: Tyrberg
authors: U
authors: U
authors: Lindblad
authors: A
authors: A
authors: Melander
authors: M
authors: M
authors: Lövestam-Adrian
authors: V
authors: V
authors: Ponjavic
authors: S
authors: S
authors: Andréasson
mesh_terms: D003623:Dark Adaptation / Q000502:physiology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D004596:Electroretinography / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012160:Retina / Q000503:physiopathology*; D012164:Retinal Diseases / Q000503:physiopathology; D012720:Severity of Illness Index