title: Tegumental alterations of Fasciola gigantica due to in vitro treatment with Ro-354.
abstract: Triclabendazole is the drug of choice against Fasciola infections in humans and   animals. However, parasite resistance against triclabendazole is spreading in veterinary   field, and there are no drugs of comparable activity currently available for the treatment and   control of fascioliasis. The efficacy of a new rhodanine derivative Ro-354 against adult   Fasciola gigantica in vitro was investigated. One hour post incubation, scanning and   transmission electron microscopic examination revealed an evident disruption of the tegument   of F. gigantica as blebbing, swelling and furrowing. Moreover, an increase in severity of   tegumental damage as sloughing and absence of spines was observed. In conclusion, Ro-354   shows potent activity against F. gigantica in vitro, and, the authors recommend carrying out   more studies to detect its efficacy in vivo.
authors: Biology Deprtment, Faculty of Science, Taibah University, Saudi Arabia.
authors: M I
authors: MI
authors: Soliman
authors: H A
authors: HA
authors: Taha
mesh_terms: D000825:Animal Structures / Q000187:drug effects / Q000648:ultrastructure; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D005209:Fasciola / Q000187:drug effects* / Q000648:ultrastructure*; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D012236:Rhodanine / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: D000871:Anthelmintics; D012236:Rhodanine