title: Vascular resistance of central retinal and ophthalmic arteries in postmenopausal women after use of tibolone.
abstract: OBJECTIVE
  The aim of this study was to evaluate the effect of tibolone on vascular resistance of the central retinal and ophthalmic artery in postmenopausal women and to compare this effect with that of placebo using transorbital ultrasound with Doppler velocimetry.
  
  
  METHODS
  We performed a prospective randomized, double-blinded, placebo-controlled study. A total of 100 healthy postmenopausal women (follicle-stimulating hormone, >40 IU/L) younger than 65 years were studied. The participants were randomly allocated to two groups: placebo (n = 50) and tibolone (2.5 mg; n = 50). Transorbital Doppler velocimetric ultrasound was performed before treatment and 80 days after.
  
  
  RESULTS
  The mean age was similar in both groups. Participants who received tibolone did not show any difference in pulsatility index, resistance index, and systole/diastole ratio of the central retinal and ophthalmic arteries after treatment. The same was observed in participants who received placebo.
  
  
  CONCLUSIONS
  Our study demonstrates that tibolone administration to healthy postmenopausal women does not affect the resistance of small-caliber cerebral arteries.
authors: UNIMONTES Medical School, Montes Claros, Minas Gerais, Brazil.
authors: Marco Aurélio Martins
authors: MA
authors: de Souza
authors: Bruno Martins
authors: BM
authors: de Souza
authors: Selmo
authors: S
authors: Geber
mesh_terms: D020847:Estrogen Receptor Modulators / Q000627:therapeutic use*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D008875:Middle Aged; D009652:Norpregnenes / Q000627:therapeutic use*; D009880:Ophthalmic Artery / Q000000981:diagnostic imaging / Q000187:drug effects*; D017698:Postmenopause / Q000187:drug effects*; D012161:Retinal Artery / Q000000981:diagnostic imaging / Q000187:drug effects*; D018608:Ultrasonography, Doppler; D014655:Vascular Resistance / Q000187:drug effects*
chemical_list: D020847:Estrogen Receptor Modulators; D009652:Norpregnenes; D005640:Follicle Stimulating Hormone; C027385:tibolone