title: Endocrinological differences between Hatano high- and low-avoidance rats during early two-way avoidance acquisition.
abstract: Hatano high (HAA)- and low (LAA)-avoidance rats were selected from Sprague-Dawley rats genetically on the basis of their active avoidance behavior in a shuttle-box test. The purpose of this study was to investigate stress-related alterations of hormones corticotropin-releasing hormone (CRH), arginine-vasopressin (AVP), prolactin, and adrenocorticotropin (ACTH) in the brain and blood during early avoidance acquisition using two lines of Hatano rats. In paraventricular nucleus (PVN) of the hypothalamus, the CRH levels in HAA rats were significantly increased after shuttle-box tasks compared with before the tasks, whereas the CRH levels in LAA rats significantly decreased after shuttle-box tasks compared with before the tasks. In the HAA rats, the CRH and AVP levels in the median eminence decreased after shuttle-box tasks, whereas there were no significant differences in the levels between before and after shuttle-box tasks in LAA rats. The plasma concentrations of ACTH were significantly higher in HAA rats than in LAA rats after shuttle-box tasks. These results show that the response of CRH-ACTH was higher in HAA rats than in LAA rats. This phenotype may be an important reason for the high avoidance rates of shuttle-box tasks in HAA rats. These endocrine differences in early avoidance acquisition may be involved in regulation of their avoidance responses in the shuttle-box task.
authors: Department of Basic Science, United Graduate School of Veterinary Sciences, Gifu University, Gifu 501-1193, Japan.
authors: Sayaka
authors: S
authors: Akieda-Asai
authors: Ryo
authors: R
authors: Ohta
authors: Mariko
authors: M
authors: Shirota
authors: Sukanya
authors: S
authors: Jaroenporn
authors: Gen
authors: G
authors: Watanabe
authors: Kazuyoshi
authors: K
authors: Taya
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000502:physiology*; D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism / Q000502:physiology*; D001362:Avoidance Learning / Q000502:physiology*; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism / Q000502:physiology*; D008297:Male; D008473:Median Eminence / Q000378:metabolism; D010286:Paraventricular Hypothalamic Nucleus / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley / Q000523:psychology*; D013315:Stress, Psychological / Q000378:metabolism / Q000523:psychology
chemical_list: D001127:Arginine Vasopressin; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D003346:Corticotropin-Releasing Hormone