title: Antiprotozoal activity of proton-pump inhibitors.
abstract: Parasitic diseases are still a major health problem in developing countries. In our effort to find new antiparasitic agents, in this Letter we report the in vitro antiprotozoal activity of omeprazole, lansoprazole, rabeprazole and pantoprazole against Trichomonas vaginalis, Giardia intestinalis and Entamoeba histolytica. Molecular modeling studies were an important tool to highlight the potential antiprotozoal activity of these drugs. Experimental evaluations revealed a strong activity for all compounds tested. Rabeprazole and pantoprazole were the most active compounds, having IC(50) values in the nanomolar range, which were even better than metronidazole, the drug of choice for these parasites.
authors: Facultad de Química, Departamento de Farmacia, UNAM, México DF 04510, Mexico.
authors: Jaime
authors: J
authors: Pérez-Villanueva
authors: Antonio
authors: A
authors: Romo-Mancillas
authors: Alicia
authors: A
authors: Hernández-Campos
authors: Lilián
authors: L
authors: Yépez-Mulia
authors: Francisco
authors: F
authors: Hernández-Luis
authors: Rafael
authors: R
authors: Castillo
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000737:chemistry / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000737:chemistry* / Q000494:pharmacology; D015195:Drug Design; D004748:Entamoeba histolytica / Q000187:drug effects; D016829:Giardia lamblia / Q000187:drug effects; D006801:Humans; D064747:Lansoprazole; D009853:Omeprazole / Q000737:chemistry / Q000494:pharmacology; D000077402:Pantoprazole; D010272:Parasitic Diseases / Q000188:drug therapy; D054328:Proton Pump Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D064750:Rabeprazole; D014246:Trichomonas vaginalis / Q000187:drug effects
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000981:Antiprotozoal Agents; D054328:Proton Pump Inhibitors; D064747:Lansoprazole; D064750:Rabeprazole; D000077402:Pantoprazole; D009853:Omeprazole