title: Halichonines A, B, and C, novel sesquiterpene alkaloids from the marine sponge Halichondria okadai Kadota.
abstract: Novel sesquiterpene alkaloids, halichonines A (1), B (2), and C (3), were identified from the marine sponge Halichondria okadai Kadota. By spectroscopic analyses and synthesis, their structures were revealed to include a 6,6-bicyclic ring system and two prenylated amine moieties. In addition, 2 induced apoptosis in HL60 human leukemia cells.
authors: Department of Chemistry, Faculty of Science and Technology, Keio University, Yokohama 223-8522, Japan.
authors: Osamu
authors: O
authors: Ohno
authors: Tatsuhiko
authors: T
authors: Chiba
authors: Seiji
authors: S
authors: Todoroki
authors: Hideaki
authors: H
authors: Yoshimura
authors: Norihito
authors: N
authors: Maru
authors: Ken
authors: K
authors: Maekawa
authors: Hiroshi
authors: H
authors: Imagawa
authors: Kaoru
authors: K
authors: Yamada
authors: Atsushi
authors: A
authors: Wakamiya
authors: Kiyotake
authors: K
authors: Suenaga
authors: Daisuke
authors: D
authors: Uemura
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D008958:Models, Molecular; D008968:Molecular Conformation; D011161:Porifera / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D012717:Sesquiterpenes