title: [Value of oxygenic injury sensitive index in the screening of the early coal workers' pneumoconiosis].
abstract: OBJECTIVE
  To study the significance of oxidative injury in the screening of coal workers' pneumoconiosis (CWP).
  
  
  METHODS
  With the method of nitrate reductase, TBA, et al, the content of NO, MDA and other indexes of peroxidation in plasma lipid were detected in 112 patients suffering from coal workers' pneumoconiosis and 114 healthy coal workers as controls.
  
  
  RESULTS
  There were statistical significant between two groups (P < 0.05) with the content or density of MDA, CuZn-SOD, GSH-Px, T-AOC, UA, NO and iNOS except CP. As screening index of pneumoconiosis, there were statistical significant in area under the curve (AUC) of MDA, T-AOC, NO and iNOS between the two groups by ROC. As screening index of pneumoconiosis, MDA, T-AOC, NO and iNOS can be selected as early screening index. Especially, T-AOC was the best index of four indexes (sensitivity is 70.5%, specificity is 68.1%).
  
  
  CONCLUSIONS
  Joint screening of MDA, T-AOC and iNOS is better than single index or series of T-AOC and MDA to the screening of CWP.
authors: Department of Preventive Medicine, School of Public Health, Heibei United University, Tangshan 063000, China. fhm01@sohu.com
authors: Hongmin
authors: H
authors: Fan
authors: Juxiang
authors: J
authors: Yuan
authors: Tianbang
authors: T
authors: Qin
authors: Hongyan
authors: H
authors: Qiu
authors: Zhuo
authors: Z
authors: Wang
authors: Jingxue
authors: J
authors: Ren
mesh_terms: D055008:Anthracosis / Q000097:blood / Q000175:diagnosis / Q000517:prevention & control*; D000975:Antioxidants / Q000378:metabolism*; D003031:Coal; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008403:Mass Screening; D008875:Middle Aged; D008906:Mining; D009569:Nitric Oxide / Q000097:blood; D052247:Nitric Oxide Synthase Type II / Q000097:blood; D016273:Occupational Exposure / Q000009:adverse effects*; D018384:Oxidative Stress; D012372:ROC Curve; D012494:Sampling Studies; D011795:Surveys and Questionnaires
chemical_list: D000975:Antioxidants; D003031:Coal; D009569:Nitric Oxide; D008315:Malondialdehyde; C496319:NOS2 protein, human; D052247:Nitric Oxide Synthase Type II