title: [Frontiers in vitamin D; Basic research and clinical application. Effect of eldecalcitol on bone structure].
abstract: Eldecalcitol, a new active vitamin D compound, has revealed to have its superiority to alfacalcidol in preventing vertebral fractures in osteoporotic subjects, as well as in preventing major non-vertebral fracture. Several animal studies demonstrated the greater efficacy in bone metabolism comparing the traditional active vitamin D, partly in relation to improvement of trabecular bone microstructure ; increase in BV/TV, Tb.N and Tb.Th, and decrease in Tb.Sp. Furthermore, three years longitudinal observation of hip geometry and biomechanical properties using clinical CT (multi-detector row CT) has disclosed an unexpected potential of eldecalcitol to improve biomechanical parameters by the increase in cortical cross-sectional area, cortical bone mass, and cortical perimeter, and by maintaining clinical thickness, probably through a more potent effect of eldecalcitol in mitigating endocortical bone resorption compared to alfacalcidol.
authors: Division of Radiology, Nagasaki University Hospital, Japan.
authors: Masako
authors: M
authors: Ito
mesh_terms: D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D001862:Bone Resorption / Q000517:prevention & control; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000378:metabolism*; D004195:Disease Models, Animal; D005598:Fractures, Spontaneous / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D051379:Mice; D015663:Osteoporosis, Postmenopausal / Q000150:complications / Q000188:drug therapy*; D010052:Ovariectomy; D051381:Rats; D016103:Spinal Fractures / Q000209:etiology / Q000517:prevention & control*; D014057:Tomography, X-Ray Computed; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D014807:Vitamin D; C547512:eldecalcitol