title: A novel electrochemical sensor for assaying of antipsychotic drug quetiapine.
abstract: A novel electrochemical sensor based on poly(2-hydroxy-5-[(4-sulfophenyl)azo]benzoic acid) film modified glassy carbon electrode for fast and simple quantification of trace amount of quetiapine fumarate (QF) was developed. It exhibits excellent enhancement effects on the electrooxidation of QF facilitating preconcentration of drug molecules on the electrode surface. Based on its strong adsorptive activity, the concentration of QF in pharmaceutical formulations and biological fluids was determined directly by voltammetry with excellent sensitivity and high selectivity. The introduction of carboxylated and sulfonated functionalities in polymer film improves the uniform selectivity for positively charged target QF molecules. The calibration curve is linear in QF concentration range of 8.0 × 10(-8) to 7.5 × 10(-6)M with detection limit 1.9 × 10(-8) and sensitivity 8.96 × 10(5) μA M(-1). The presented sensor has long term stability and good reproducibility with benefits of fast response time, ease of preparation and regeneration of the surface that makes the proposed method useful in the determination of QF in real samples.
authors: University of Zagreb, Faculty of Pharmacy and Biochemistry, A. Kovacica 1, 10000 Zagreb, Croatia. biljana@pharma.hr
authors: Biljana
authors: B
authors: Nigović
authors: Josipa
authors: J
authors: Spajić
mesh_terms: D014150:Antipsychotic Agents / Q000032:analysis*; D003987:Dibenzothiazepines / Q000032:analysis*; D055664:Electrochemical Techniques / Q000379:methods*; D006801:Humans; D017736:Ion-Selective Electrodes; D000069348:Quetiapine Fumarate
chemical_list: D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate