title: Consecutive three-component synthesis of 3-(hetero)aryl-1H-pyrazoles with propynal diethylacetal as a three-carbon building block.
abstract: A novel consecutive three-component synthesis of 3-(hetero)aryl-1H-pyrazoles via room temperature Sonogashira arylation of propynal diethylacetal used as a propargyl aldehyde synthetic equivalent has been disclosed. The final acetal cleavage-cyclocondensation with hydrazine hydrochloride at 80 °C rapidly furnishes the title compounds in a one-pot fashion.
authors: Institut für Organische Chemie und Makromolekulare Chemie, Heinrich-Heine-Universität Düsseldorf, Germany.
authors: Lucilla
authors: L
authors: Levi
authors: Christina
authors: C
authors: Boersch
authors: Charlotte F
authors: CF
authors: Gers
authors: Eugen
authors: E
authors: Merkul
authors: Thomas J J
authors: TJ
authors: Müller
mesh_terms: D000080:Acetals / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000080:Acetals; D007454:Iodides; D011720:Pyrazoles; D002244:Carbon