title: Zwitterionic sulfobetaine lipids that form vesicles with salt-dependent thermotropic properties.
abstract: We describe a class of zwitterionic sulfobetaine (SB) lipids with fascinating salt-dependent properties. SB lipids are zwitter-neutral across a broad pH range; however they have negative surface potentials in the presence of anions and two salt-dependent transition temperatures. These new SB lipids provide insight on the role of charge orientation at the membrane interface and may be useful components in drug delivery systems.
authors: Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.
authors: Emily K
authors: EK
authors: Perttu
authors: Francis C
authors: FC
authors: Szoka
mesh_terms: D001622:Betaine / Q000031:analogs & derivatives* / Q000737:chemistry; D008051:Lipid Bilayers / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry*; D010713:Phosphatidylcholines / Q000737:chemistry*; D012492:Salts / Q000737:chemistry*; D013499:Surface Properties; D013696:Temperature; D044366:Transition Temperature
chemical_list: D008051:Lipid Bilayers; D008081:Liposomes; D010713:Phosphatidylcholines; D012492:Salts; D001622:Betaine; C483727:sulfobetaine