title: Inhibition of sodium current by taurine magnesium coordination compound prevents cesium chloride-induced arrhythmias.
abstract: The mechanism(s) by which taurine magnesium coordination compound (TMCC) inhibits experimental arrhythmias remains poorly understood. The purpose of this study was to observe the effects of TMCC against cesium chloride-induced arrhythmia in the rabbit heart and find whether the antiarrhythmic activity is related to inhibition of sodium current. Early afterdepolarization was induced by 1.5 mM cesium chloride (1 ml kg(-1)) through intravenous injection. The monophasic action potentials (MAP) and electrocardiograms were simultaneously recorded. The effect of TMCC on functional refractory periods (FRPs) in the left atrium was also observed in vitro. Arrhythmias onset was significantly retarded by TMCC. The number of ventricular premature contractions and incidence of monophasic ventricular tachycardia and polyphasic ventricular tachycardia in 10 min were decreased by TMCC. These effects can be abolished by veratridine (10 μg kg(-1)). MAP duration at 90% repolarization was significantly prolonged by TMCC, which can be prolonged even longer by veratridine (10 μg kg(-1)). In vitro experiments showed that FRPs was prolonged by TMCC which can be cancelled by veratridine (10 μg kg(-1)). TMCC prevents cesium chloride-induced arrhythmias, and inhibition of sodium current, in part, contributes to the antiarrhythmic effect of TMCC.
authors: Department of Pharmacology, Tianjin Medical University, Tianjin, China.
authors: Yongqiang
authors: Y
authors: Yin
authors: Ke
authors: K
authors: Wen
authors: Yanna
authors: Y
authors: Wu
authors: Yi
authors: Y
authors: Kang
authors: Jianshi
authors: J
authors: Lou
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D002586:Cesium; D002712:Chlorides; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D008274:Magnesium / Q000737:chemistry; D015394:Molecular Structure; D009200:Myocardial Contraction / Q000187:drug effects; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits; D015222:Sodium Channels / Q000502:physiology*; D013654:Taurine / Q000737:chemistry; D014701:Veratridine / Q000494:pharmacology
chemical_list: D002712:Chlorides; D009942:Organometallic Compounds; D015222:Sodium Channels; D013654:Taurine; D002586:Cesium; D014701:Veratridine; C028019:cesium chloride; D008274:Magnesium