title: Intercepting Wacker intermediates with arenes: C-H functionalization and dearomatization.
abstract: An intramolecular cyclization cascade reaction has been developed utilizing a high valent palladium intermediate that generates a carbon-carbon and carbon-oxygen bond in a single transformation. This method provides rapid access to highly functionalized tricyclic scaffolds, including spirocyclic cyclohexadienones. Good yields and mild conditions are reported with high tolerance toward oxygen and water.
authors: Department of Chemistry, Boston University, Boston, Massachusetts 02215, USA.
authors: Bryan S
authors: BS
authors: Matsuura
authors: Allison G
authors: AG
authors: Condie
authors: Ian A
authors: IA
authors: McBee
authors: Ryan C
authors: RC
authors: Buff
authors: Gregory J
authors: GJ
authors: Karahalis
authors: Corey R J
authors: CR
authors: Stephenson
mesh_terms: D002384:Catalysis; D003500:Cyclization; D053138:Cyclohexenes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D053138:Cyclohexenes; D013141:Spiro Compounds; C507608:cyclohexadienone; D014867:Water; D010165:Palladium; D010100:Oxygen