title: Surgical revision of biliary strictures following adult live donor liver transplantation: patient selection, morbidity, and outcomes.
abstract: Biliary strictures after live donor liver transplantation (LDLT) are frequent and difficult to manage. The outcomes of surgical correction of biliary anastomotic complications remain unclear. Clinical outcomes of patients requiring surgical revision of their biliary anastomosis following LDLT were analyzed. Of 296 consecutive right lobe LDLTs, approximately 21% of patients developed biliary strictures. Of these patients, twelve required surgical revision of a biliary anastomotic stricture. For patients who had operative repair, the average time from transplantation to stricture diagnosis was 7.6 months. Mean time to surgical correction was 8.2 months from the time of stricture diagnosis. Eight of 12 (67%) patients no longer require any intervention with a mean follow-up of 43.7 months. Two of 12 patients require intermittent medical treatment for presumed cholangitis, but have not required biliary interventions. Two patients have required chronic PTC catheter drainage. The 30-day postoperative morbidity was 58%, with four serious (Grade 3) complications occurring in three patients. Early stricture repair (<6 months from diagnosis of stricture) and younger donor grafts were associated with better surgical outcomes. Timely surgical correction of biliary strictures is successful and durable in appropriately selected patients. However, operative repair is associated with significant postoperative morbidity.
authors: Multi-Organ Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
authors: Trevor W
authors: TW
authors: Reichman
authors: Charbel
authors: C
authors: Sandroussi
authors: David R
authors: DR
authors: Grant
authors: Mark S
authors: MS
authors: Cattral
authors: Paul D
authors: PD
authors: Greig
authors: Gary
authors: G
authors: Levy
authors: Ian D
authors: ID
authors: McGilvray
mesh_terms: D000328:Adult; D000368:Aged; D001652:Bile Ducts / Q000601:surgery; D001662:Biliary Tract Surgical Procedures / Q000379:methods*; D003251:Constriction, Pathologic / Q000601:surgery*; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000401:mortality* / Q000628:therapy*; D016031:Liver Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D012086:Reoperation / Q000379:methods; D012984:Software; D013997:Time Factors; D016896:Treatment Outcome