title: PGC-1 coactivators in the cardiovascular system.
abstract: The beating heart consumes more ATP per weight than any other organ. The machineries required for this are many and complex. Fuel and oxygen must be transported via the vasculature, absorbed by cardiomyocytes, broken down, and regulated to match cellular demands. Much of this occurs in mitochondria, which comprise fully one third of cardiac mass. The PGC-1 proteins are transcriptional coactivators that have emerged as powerful orchestrators of these numerous processes, ensuring their proper coregulation in response to intracellular and extracellular cues. An important role for PGC-1s in cardiac function has been revealed over the past few years, and more recently interest in their role in the vasculature has been burgeoning. We review this literature, focusing on recent developments.
authors: Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
authors: Ian S
authors: IS
authors: Patten
authors: Zolt
authors: Z
authors: Arany
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects / Q000378:metabolism*; D002352:Carrier Proteins / Q000502:physiology*; D015870:Gene Expression / Q000187:drug effects; D006321:Heart / Q000502:physiology*; D006333:Heart Failure / Q000503:physiopathology; D006360:Heat-Shock Proteins / Q000502:physiology* / Q000627:therapeutic use; D006801:Humans; D008929:Mitochondria, Heart / Q000187:drug effects / Q000502:physiology; D009206:Myocardium / Q000378:metabolism; D032383:Myocytes, Cardiac / Q000378:metabolism; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D011499:Protein Processing, Post-Translational; D016601:RNA-Binding Proteins; D014157:Transcription Factors / Q000502:physiology* / Q000627:therapeutic use; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis
chemical_list: D002352:Carrier Proteins; D006360:Heat-Shock Proteins; C486497:PPARGC1A protein, human; C455622:PPARGC1B protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D016601:RNA-Binding Proteins; D014157:Transcription Factors; D042461:Vascular Endothelial Growth Factor A; C111264:peroxisome-proliferator-activated receptor-gamma coactivator-1; D000255:Adenosine Triphosphate