title: Protein binding in patients with late-life depression.
abstract: BACKGROUND
  Depression has been identified as a risk factor and a prodrome of dementia. Common neurobiological mechanisms may underlie this clinical and phenomenologic overlap.
  
  
  OBJECTIVE
  To examine and compare protein (amyloid and tau) binding in critical brain regions in patients diagnosed as having late-life major depressive disorder (MDD) and healthy control individuals using 2-(1-{6-[(2-[(18)F]fluoroethyl)(methyl)-amino]-2-naphthyl}ethylidene) malononitrile ([(18)F]FDDNP) positron emission tomography.
  
  
  METHODS
  A cross-section neuroimaging study using positron emission tomography.
  
  
  METHODS
  University of California, Los Angeles. Patients  Our samples comprised 20 patients diagnosed as having MDD and 19 healthy control individuals of comparable age, sex, and educational level. Main Outcome Measure  Relative distribution volume in regions of interest was used as the measure of [(18)F]FDDNP binding in all study participants.
  
  
  RESULTS
  When compared with controls, [(18)F]FDDNP binding was significantly higher overall and in the posterior cingulate and lateral temporal regions in the MDD group.
  
  
  CONCLUSIONS
  These findings suggest that neuronal injury associated with higher protein load in critical brain regions might provide a mechanism in the pathophysiologic manifestation of MDD in late life and have implications for the therapeutics of depression in elderly individuals.
authors: Department of Psychiatry, University of Illinois at Chicago, USA. akumar@psych.uic.edu
authors: Anand
authors: A
authors: Kumar
authors: Vladimir
authors: V
authors: Kepe
authors: Jorge R
authors: JR
authors: Barrio
authors: Prabha
authors: P
authors: Siddarth
authors: Vicki
authors: V
authors: Manoukian
authors: Virginia
authors: V
authors: Elderkin-Thompson
authors: Gary W
authors: GW
authors: Small
mesh_terms: D017668:Age of Onset; D000368:Aged; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D003430:Cross-Sectional Studies; D003704:Dementia / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D003865:Major Depressive Disorder / Q000150:complications / Q000453:epidemiology* / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006179:Gyrus Cinguli / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging / Q000379:methods; D058225:Plaque, Amyloid / Q000378:metabolism*; D049268:Positron-Emission Tomography; D011485:Protein Binding; D013702:Temporal Lobe / Q000378:metabolism / Q000473:pathology; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D016229:Amyloid beta-Peptides; D016875:tau Proteins