title: Enhancement of affinity in molecular recognition via hydrogen bonds by POSS-core dendrimer and its application for selective complex formation between guanosine triphosphate and 1,8-naphthyridine derivatives.
abstract: We report that a polyhedral oligomeric silsesquioxane (POSS) core in a dendrimer can enhance the affinity of the molecular recognition via hydrogen bonds between 1,8-naphthyridine and guanosine nucleotides. The complexation of the naphthyridine ligands with a series of guanosine nucleotides was investigated, and it is shown that the POSS core should play a significant role in the stabilization of the complexes via hydrogen bonds. Finally, we demonstrate that the 1,8-naphthyridine ligand can selectively recognize guanosine triphosphate by assisting with the POSS-core dendrimer.
authors: Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
authors: Kazuo
authors: K
authors: Tanaka
authors: Masahiro
authors: M
authors: Murakami
authors: Jong-Hwan
authors: JH
authors: Jeon
authors: Yoshiki
authors: Y
authors: Chujo
mesh_terms: D050091:Dendrimers; D006160:Guanosine Triphosphate / Q000737:chemistry*; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009287:Naphthyridines / Q000737:chemistry*; D013050:Spectrometry, Fluorescence
chemical_list: D050091:Dendrimers; D009287:Naphthyridines; D006160:Guanosine Triphosphate