title: Emotion and cognitive function assessment of patients with central neurocytoma resection through transcortical frontal approach: a 5-year postoperative follow-up study.
abstract: BACKGROUND
  Central neurocytoma accounts for 0.1% of primary brain tumor that often occurs in young adults. Surgery is the main treatment for central neurocytoma and the rate of 5-year survival reaches up to over 90%. This study aimed to assess the effect of transcortical frontal approach to surgical resection of central neurocytoma on emotion and cognitive function 5 years after surgery.
  
  
  METHODS
  Telephone following-up visits were used in this study. By means of neuropsychological testing, assayed emotion, memory and abstract thinking ability of 18 patients undergoing central neurocytoma resection by transcortical frontal approach for 5 years or more, with another 21 normal cases as control group were enrolled. The data were analyzed statistically by paired t test with SPSS11.5.
  
  
  RESULTS
  Patients whose central neurocytoma was removed by transcortical frontal approach were not affected on calculating ability 5 years after operation while ability of memory declined sharply (P = 0.000), the older, the more sharply (P = 0.036). Ability of abstract thinking was significantly reduced (P = 0.000), the older, the more significantly as well (P = 0.012); additionally, anxiety and depression occurred in patients rather more than those of control group (P = 0.000), especially cognitive impairment.
  
  
  CONCLUSIONS
  Transcortical frontal approach for surgical resection of central neurocytoma has certain long-term influence on patients' life quality, vulnerable to anxiety, depression and cognitive impairment, the severity of which was correlated to age. Therefore, improving surgical approach will be of value for better long-term life quality of patients.
authors: Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
authors: Zhi-feng
authors: ZF
authors: Shi
authors: Da-liang
authors: DL
authors: Sun
authors: Jian-ping
authors: JP
authors: Song
authors: Yu
authors: Y
authors: Yao
authors: Ying
authors: Y
authors: Mao
mesh_terms: D000293:Adolescent; D000328:Adult; D003071:Cognition / Q000502:physiology*; D004644:Emotions / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018306:Neurocytoma / Q000401:mortality / Q000503:physiopathology* / Q000523:psychology* / Q000601:surgery; D011184:Postoperative Period; D055815:Young Adult