title: Angiodema due to oral acitretin and isotretinoin.
abstract: Angioedema may be caused by nonsteroidal antiinflammatory drugs, angiotensin- converting enzyme inhibitors, radiocontrast media, antibiotics, sea food etc. It can involve an allergic (IgE-mediated) or non-allergic hypersensitivity reaction, both with a similar clinical presentation. While angioedema due to isotretionin has been described previously, this is the first description of angiodema due to acitretin. We report two uncommon cases of palpebral and labial angiodema due to retinoids, by acitretin and oral isotretinoin respectively: a 48-year-old man with psoriasis and a 24-year-old woman with severe acne resistant to antibiotics and topical drugs. In both cases the reaction persisted through-out treatment with these drugs, but resolved quickly after discontinuation. Reintroduction of the drugs brought on angioedema again.
authors: Catholic University of Pelotas, Probation Ambulatory, Oeste de Santa Catarina University, Joaçaba, SC, Brazil. robertodermatologista@yahoo.com.br
authors: Roberto Rheingantz da
authors: RR
authors: Cunha Filho
authors: Hiram Larangeira de
authors: HL
authors: Almeida
authors: Juliano de Avelar
authors: Jde A
authors: Breunig
mesh_terms: D017255:Acitretin / Q000009:adverse effects*; D000799:Angioedema / Q000139:chemically induced*; D003879:Dermatologic Agents / Q000009:adverse effects*; D005148:Facial Dermatoses / Q000139:chemically induced*; D005260:Female; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D003879:Dermatologic Agents; D015474:Isotretinoin; D017255:Acitretin