title: Preinvasive lesions of the bronchus.
abstract: It has been proposed that invasive carcinoma of the bronchus develops through a transition from preinvasive lesions to overt malignancy. Newer diagnostic technologies have provided a more sensitive way to diagnose preinvasive lesions and a better understanding of the prevalence of such lesions. The natural history of preinvasive lesions has not been well defined; however, there is evidence that high-grade lesions are at a higher risk of progression to carcinoma. Molecular alterations have been described in preinvasive lesions and may help better predict which lesions will progress. Several noninvasive techniques are available for the treatment of high-grade lesions.
authors: Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of North Carolina at Chapel Hill, 4133 Bioinformatics Building, Mason Farm Road, CB # 7020, Chapel Hill, NC 27516, USA. mprivera@med.unc.edu
authors: M Patricia
authors: MP
authors: Rivera
mesh_terms: D001980:Bronchi / Q000473:pathology*; D001999:Bronchoscopy; D002278:Carcinoma in Situ / Q000175:diagnosis / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D018450:Disease Progression; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D008679:Metaplasia / Q000235:genetics / Q000473:pathology; D060787:Neoplasm Grading; D011230:Precancerous Conditions / Q000175:diagnosis / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D020545:Respiratory Mucosa / Q000473:pathology*