title: Fifty years of X-inactivation research.
abstract: The third X-inactivation meeting 'Fifty years of X-inactivation research', which celebrated the fiftieth anniversary of Mary Lyon's formulation of the X-inactivation hypothesis, was an EMBO workshop held in Oxford, UK, in July 2011. This conference brought together the usual suspects from the field, as well as younger researchers, to discuss recent advances in X-inactivation research. Here, we review the results presented at the meeting and highlight some of the exciting progress that has been made. We also discuss the future challenges for the field, which aim to further our understanding of the developmental regulation of X inactivation, the randomness (or skewing) of X inactivation, and the diverse strategies used by mammalian species to mediate X inactivation.
authors: Mammalian Developmental Epigenetics Group, Genetics and Developmental Biology Unit, Institut Curie, CNRS UMR3215, INSERM U934, 75248 Paris, France.
authors: Anne-Valerie
authors: AV
authors: Gendrel
authors: Edith
authors: E
authors: Heard
mesh_terms: D000818:Animals; D050172:Genes, X-Linked / Q000235:genetics*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D051379:Mice; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated / Q000378:metabolism*; D012106:Research / Q000266:history* / Q000639:trends*; D013045:Species Specificity; D049951:X Chromosome Inactivation / Q000502:physiology*
chemical_list: D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; C077885:XIST non-coding RNA