title: Effect of pomegranate seed oil on serum TNF-α level in dyslipidemic patients.
abstract: Pomegranate punicic acid and pomegranate fruit extracts have the potential effects in inhibiting tumour necrosis factor-α (TNF-α) and inflammatory diseases. The aim of this study was to evaluate the effect of pomegranate seed oil (PSO) consumption on serum TNF-α level in dyslipidemic patients. Fifty-one subjects with serum total cholesterol concentration >200 mg/dl and serum triglyceride concentrations >150 mg/dl were randomly assigned into the PSO (n = 25) and placebo (n = 26) groups. Subjects were given 400 mg PSO or placebo capsules twice daily for 4 weeks. Six patients were excluded because of complications or lack of compliance. Serum TNF-α level was measured at baseline and after 4 weeks. Mean (SD) serum concentration of TNF-α decreased from 14.73 ± 5.25 to 13.28 ± 3.79 pg/ml in the PSO group (P = NS). Corresponding values in the placebo group were 12.46 ± 1.67 versus 13.14 ± 1.67 pg/ml (P = NS). In conclusion, administration of PSO in dyslipidemic patients does not affect the serum TNF-α.
authors: Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Golaleh
authors: G
authors: Asghari
authors: Sara
authors: S
authors: Sheikholeslami
authors: Parvin
authors: P
authors: Mirmiran
authors: Abdolreza
authors: A
authors: Chary
authors: Mehdi
authors: M
authors: Hedayati
authors: Abbas
authors: A
authors: Shafiee
authors: Fereidoun
authors: F
authors: Azizi
mesh_terms: D004311:Double-Blind Method; D050171:Dyslipidemias / Q000097:blood*; D005260:Female; D006801:Humans; D029561:Lythraceae / Q000196:embryology*; D008297:Male; D010919:Placebos; D010938:Plant Oils / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D010919:Placebos; D010938:Plant Oils; D014409:Tumor Necrosis Factor-alpha