title: Lipophilicity study of some non-steroidal anti-inflammatory agents and cephalosporin antibiotics: a review.
abstract: Lipophilicity properties have long been considered a vital component of drug discovery and development, providing insight into the role of molecular properties in the biological activity of known and new compounds. An extensive survey of the literature published in analytical and pharmaceutical chemistry journals has been conducted. Separation, optical, electrochemical and calculation methods which were developed and used for determination of lipophilicity non-steroidal anti-inflammatory agents and cephalosporin antibiotics in drugs and biological materials, have been reviewed. This review covers over 100 miscellaneous methods. Presented review highlighted some recent developments and new techniques that have been used in the lipophilicity detection of two different kinds of drugs.
authors: Jagiellonian University, Collegium Medicum, Faculty of Pharmacy, Department of Inorganic and Analytical Chemistry, 9 Medyczna Street, 30-688 Cracow, Poland. mtylka@cm-uj.krakow.pl
authors: Monika
authors: M
authors: Dąbrowska
authors: Małgorzata
authors: M
authors: Starek
authors: Jerzy
authors: J
authors: Skuciński
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000493:pharmacokinetics; D002511:Cephalosporins / Q000737:chemistry* / Q000493:pharmacokinetics; D002626:Chemistry, Pharmaceutical / Q000379:methods* / Q000639:trends; D006801:Humans; D008055:Lipids / Q000737:chemistry* / Q000493:pharmacokinetics; D012995:Solubility / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002511:Cephalosporins; D008055:Lipids