title: Effect of intraocular lens asphericity on posterior capsule opacification between two intraocular lenses with same acrylic material: a fellow-eye study.
abstract: OBJECTIVE
  To evaluate intra-individual differences in posterior capsule opacification (PCO) and visual performance between spherical AcrySof SN60AT and an aspheric AcrySof SN60WF intraocular lens (IOL) with a posterior aspheric surface, both of which are made of same hydrophobic acrylic material.
  
  
  METHODS
  Ophthalmology Department, St Thomas' Hospital, London, UK.
  
  
  METHODS
  In this prospective randomized, fellow-eye comparison, an aspheric IOL, which is 9% thinner in comparison with the spherical IOL, was randomized to the first eye of 47 patients and fellow-eye surgery was performed within 3 weeks. Follow-up was at 1, 3, 6, 12 and 24 months. Corrected logMAR visual acuity (CDVA) was measured at 100% and 9% contrast. After pupil dilation, digital retroillumination photographs were taken and the mean PCO percentage was calculated using poco software at each follow-up visit.
  
  
  RESULTS
  At 1, 3, 6, 12 and 24 months, 47 (94 eyes), 44 (88 eyes), 42 (84 eyes) and 41 (82 eyes) patients were followed-up respectively. Hundred per cent and 9% of LogMAR CDVA was not significantly different between the two IOLs (p = NS at all time-points). Percentage area PCO scores (mean ± SD) at 1, 3, 6, 12 and 24 months with the spherical IOL was 5.82 ± 9.89, 7.76 ± 16.83, 7.21 ± 12.46, 9.29 ± 18.25 and 14.39 ± 25.42, respectively, and with an aspheric IOL was 8.91 ± 12.79, 5.97 ± 10.32, 5.15 ± 7.92, 7.68 ± 11.18 and 12.18 ± 20.10, respectively (p = NS at all time-points).
  
  
  CONCLUSIONS
  Posterior capsule opacification was not significantly different between the spheric and aspheric IOLs in this fellow-eye, randomized comparison. Additional asphericity on the existing model of IOL does not influence PCO performance.
authors: Department of Ophthalmology, St Thomas' Hospital, London SE1 7EH, UK. mayank_nanavaty@hotmail.com
authors: Mayank A
authors: MA
authors: Nanavaty
authors: David J
authors: DJ
authors: Spalton
authors: Kavita B
authors: KB
authors: Gala
authors: Anish
authors: A
authors: Dhital
authors: James
authors: J
authors: Boyce
mesh_terms: D000180:Acrylic Resins; D000368:Aged; D058442:Capsule Opacification / Q000209:etiology* / Q000503:physiopathology; D005500:Follow-Up Studies; D006801:Humans; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular / Q000009:adverse effects*; D018918:Phacoemulsification; D057852:Posterior Capsule of the Lens / Q000473:pathology*; D011446:Prospective Studies; D011474:Prosthesis Design; D019591:Pseudophakia / Q000503:physiopathology; D014792:Visual Acuity / Q000502:physiology
chemical_list: D000180:Acrylic Resins