title: ADAM-15 disintegrin-like domain structure and function.
abstract: The ADAM (a disintegrin-like and metalloproteinase) proteins are a family of transmembrane cell-surface proteins with important functions in adhesion and proteolytic processing in all animals. Human ADAM-15 is the only member of the ADAM family with the integrin binding motif Arg-Gly-Asp (RGD) in its disintegrin-like domain. This motif is also found in most snake venom disintegrins and other disintegrin-like proteins. This unique RGD motif within ADAM-15 serves as an integrin ligand binding site, through which it plays a pivotal role in interacting with integrin receptors, a large family of heterodimeric transmembrane glycoproteins. This manuscript will present a review of the RGD-containing disintegrin-like domain structures and the structural features responsible for their activity as antagonists of integrin function in relation to the canonical RGD template.
authors: Thrombosis Research Institute, Manresa Road, London, SW3 6LR, UK. xlu@tri-london.ac.uk
authors: Dong
authors: D
authors: Lu
authors: Mike
authors: M
authors: Scully
authors: Vijay
authors: V
authors: Kakkar
authors: Xinjie
authors: X
authors: Lu
mesh_terms: D051722:ADAM Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D050197:Atherosclerosis / Q000378:metabolism; D019483:Disintegrins / Q000737:chemistry / Q000235:genetics; D006801:Humans; D016023:Integrins / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism; D017434:Protein Structure, Tertiary
chemical_list: D019483:Disintegrins; D016023:Integrins; D008565:Membrane Proteins; D051722:ADAM Proteins