title: Use of in vivo real-time optical imaging for esophageal neoplasia.
abstract: Esophageal adenocarcinoma carries a poor prognosis, as it typically presents at a late stage. Thus, a major research priority is the development of novel diagnostic-imaging strategies that can detect neoplastic lesions earlier and more accurately than current techniques. Advances in optical imaging allow clinicians to obtain real-time histopathologic information with instant visualization of cellular architecture and the potential to identify neoplastic tissue. The various endoscopic imaging modalities for esophageal neoplasia can be grouped into 2 major categories: (1) wide-field imaging, a comparatively lower-resolution view for imaging larger surface areas, and (2) high-resolution imaging, which allows individual cells to be visualized. This review will provide an overview of the various forms of real-time optical imaging in the diagnosis and management of Barrett's esophagus and esophageal adenocarcinoma.
authors: Mount Sinai School of Medicine, New York, NY, USA.
authors: Peter M
authors: PM
authors: Vila
authors: Nadhi
authors: N
authors: Thekkek
authors: Rebecca
authors: R
authors: Richards-Kortum
authors: Sharmila
authors: S
authors: Anandasabapathy
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis*; D001471:Barrett Esophagus / Q000175:diagnosis*; D004938:Esophageal Neoplasms / Q000175:diagnosis*; D004945:Esophagoscopy; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D018613:Microscopy, Confocal; D011230:Precancerous Conditions / Q000175:diagnosis*; D041623:Tomography, Optical Coherence