title: Inhibition of hemorragic snake venom components: old and new approaches.
abstract: Snake venoms are complex toxin mixtures. Viperidae and Crotalidae venoms, which are hemotoxic, are responsible for most of the envenomations around the world. Administration of antivenins aimed at the neutralization of toxins in humans is prone to potential risks. Neutralization of snake venom toxins has been achieved through different approaches: plant extracts have been utilized in etnomedicine. Direct electric current from low voltage showed neutralizing properties against venom phospholipase A2 and metalloproteases. This mini-review summarizes new achievements in venom key component inhibition. A deeper knowledge of alternative ways to inhibit venom toxins may provide supplemental treatments to serum therapy.
authors: Department of Biology, University of Genova, Viale Benedetto XV 3, 16132 Genova, Italy. isabella.panfoli@unige.it
authors: Isabella
authors: I
authors: Panfoli
authors: Daniela
authors: D
authors: Calzia
authors: Silvia
authors: S
authors: Ravera
authors: Alessandro
authors: A
authors: Morelli
mesh_terms: D000818:Animals; D000997:Antivenins / Q000494:pharmacology; D004599:Electric Stimulation Therapy; D006470:Hemorrhage / Q000139:chemically induced*; D006801:Humans; D045726:Metalloproteases / Q000037:antagonists & inhibitors*; D064801:Phospholipase A2 Inhibitors; D010936:Plant Extracts / Q000494:pharmacology; D012909:Snake Bites / Q000628:therapy; D012910:Snake Venoms / Q000037:antagonists & inhibitors* / Q000633:toxicity
chemical_list: D000997:Antivenins; D064801:Phospholipase A2 Inhibitors; D010936:Plant Extracts; D012910:Snake Venoms; D045726:Metalloproteases