title: Outcome of pregnancy in type 1 diabetes mellitus (T1DMP): results from combined diabetes-obstetrical clinics in Dublin in three university teaching hospitals (1995-2006).
abstract: OBJECTIVE
  To compare the pregnancy outcomes in all T1DMP attending at combined (diabetes-obstetric) outpatients clinics in three university teaching hospitals in Dublin from 1995 to 2006 with a non-diabetic control population (C) attending at antenatal outpatient clinics at the same hospitals over the same period.
  
  
  METHODS
  T1DMP (n = 600) were compared with control non-diabetic pregnancies (n = 142,498).
  
  
  RESULTS
  The spontaneous abortion rate was 15% in T1DMP versus 8% in C (p < 0.0001). Perinatal mortality rate was 3.3% in T1DMP compared to 0.9% in C (p < 0.001). The incidence of foetal macrosomia was 29% in T1DMP versus 16% in C (p < 0.001).
  
  
  CONCLUSIONS
  Pregnancy outcomes in T1DMP remain worse than in the general population despite management of T1DMP in combined obstetric/diabetes clinics in a single centre using similar management protocols. These outcomes in our study population of T1DMP in Dublin appear better than some previously reported studies.
authors: Dublin Diabetes Pregnancy Centre, Mater Misericordiae University Hospital, 30 Eccles Street, Dublin 7, Ireland. rany2075@yahoo.com
authors: R
authors: R
authors: Al-Agha
authors: R G
authors: RG
authors: Firth
authors: M
authors: M
authors: Byrne
authors: S
authors: S
authors: Murray
authors: S
authors: S
authors: Daly
authors: M
authors: M
authors: Foley
authors: S C
authors: SC
authors: Smith
authors: B T
authors: BT
authors: Kinsley
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology*; D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005260:Female; D005320:Fetal Macrosomia / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D007494:Ireland / Q000453:epidemiology; D054238:Perinatal Mortality; D011247:Pregnancy; D011248:Pregnancy Complications