title: Evaluation of the humoral immune response in adult dairy cattle three years after vaccination with a bluetongue serotype 8 inactivated vaccine.
abstract: Despite the widespread use of bluetongue serotype 8 (BTV-8) inactivated vaccines across Europe from 2008 to 2011, two very practical questions remain unanswered about the length of persistence of group-specific antibodies in milk and serum post-vaccination and the duration of protection beyond one year post-vaccination. This study has firstly revealed that group-specific antibodies persist at high levels in milk and serum in the majority of cattle for at least 3 years post-vaccination, thus removing the option of using these animals in ELISA-based surveillance programmes. Secondly neutralising antibodies have been shown to persist in the majority of cattle for at least 3 years post-vaccination, indicating that the cattle are likely to be protected for this time period. This extended duration of protection may have contributed towards the rapid and efficient eradication of BTV-8 from many European countries, despite reducing levels of vaccine coverage.
authors: Institute for Animal Health, Pirbright Laboratory, Ash Road, Woking, Surrey GU240NF, UK. chris.oura@iah.ac.uk
authors: C A L
authors: CA
authors: Oura
authors: L
authors: L
authors: Edwards
authors: C A
authors: CA
authors: Batten
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing / Q000032:analysis / Q000097:blood; D000914:Antibodies, Viral / Q000032:analysis* / Q000097:blood*; D001769:Blood / Q000276:immunology; D001819:Bluetongue / Q000276:immunology* / Q000517:prevention & control*; D001820:Bluetongue virus / Q000276:immunology*; D002417:Cattle; D005060:Europe; D005260:Female; D005500:Follow-Up Studies; D008892:Milk / Q000276:immunology; D013997:Time Factors; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D015164:Vaccines, Inactivated; D014765:Viral Vaccines