title: Clinical effects of autologous stem cell transplantation as consolidation treatment in 70 multiple myeloma patients: a case-controlled study.
abstract: BACKGROUND
  Autologous stem cell transplantation (ASCT) is a part of the standard induction therapy of multiple myeloma (MM). This case-controlled clinical trial aimed to further evaluate the therapeutic effects of ASCT as a consolidation therapy for MM and discuss factors influencing the prognosis.
  
  
  METHODS
  Clinical data of 70 patients diagnosed as MM who received ASCT as a consolidation therapy in our hospital between October 1998 and August 2010 were analyzed retrospectively (ASCT group). Other 70 MM patients receiving routine chemotherapy without ASCT (non-ASCT group) during the same period were used as controls. Differences in the degree and duration of remission, progression-free survival (PFS) and overall survival (OS) were compared to explore factors that may influence the prognosis.
  
  
  RESULTS
  The median follow-up period was 38 months (range 1 - 128 months). The complete response (CR) rate of ASCT group increased from 27.1% (19/70) before ASCT to 51.4% (36/70) after ASCT. The median PFS of ASCT group was significantly higher than non-ASCT group (45 months vs. 25 months, P < 0.001). The median OS of ASCT group was also significantly higher (55 months vs. 30 months, P = 0.016). Single-factor analysis showed that International Staging System (ISS) stage, very good partial response (VGPR) or better outcome were significantly correlated with PFS and OS (P < 0.001). Multi-factor analysis showed that whether or not VGPR or better outcome was achieved were independent factors influencing the disease prognosis.
  
  
  CONCLUSIONS
  Used as a consolidation therapy, ASCT can achieve better responses and higher OS and PFS of MM patients.
authors: Division of Hematology, Changzheng Hospital, Second Millitary Medical University, Shanghai 200003, China.
authors: Li-Li
authors: LL
authors: Zhou
authors: Zhen-Gang
authors: ZG
authors: Yuan
authors: Wei-Jun
authors: WJ
authors: Fu
authors: Hao
authors: H
authors: Xi
authors: Chun-Yang
authors: CY
authors: Zhang
authors: Hai-Feng
authors: HF
authors: Lan
authors: Xin
authors: X
authors: Zhang
authors: Yu
authors: Y
authors: Chen
authors: Wen-Yu
authors: WY
authors: Liu
authors: Jian
authors: J
authors: Hou
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000628:therapy*; D011379:Prognosis; D012074:Remission Induction; D012189:Retrospective Studies; D033581:Stem Cell Transplantation; D014182:Transplantation, Autologous; D016896:Treatment Outcome