title: Fibrous hamartoma of infancy: an experience of a single institute.
abstract: OBJECTIVE
  Fibrous hamartoma (FH) of infancy is a distinctive fibrous growth that most frequently occurs at birth and during the postnatal period. It is important for clinicians and pathologists to recognize this entity to avoid an aggressive approach.
  
  
  METHODS
  We herein describe the clinicopathologic features of 9 FHs diagnosed at a single institution between 1997 and 2010.
  
  
  RESULTS
  There were 7 boys and 2 girls, and the mean age of presentation was 14.7 months. The common locations were the lower back and gluteal region (n = 3) and scrotum (n = 2). They were solitary lesions, and measured 1.0 to 7.0 cm in maximum diameter (mean, 4.9 cm). The excised masses tended to be poorly circumscribed, and consisted of an intimate mixture of firm, gray-white tissue with fat. Histologically, these lesions were composed of 3 components forming a vague, irregular, organoid pattern: well-defined intersecting trabeculae of fibrocollagenous tissue; loosely textured areas of small, rounded, primitive mesenchymal cells; and mature fat. Over a median follow-up of 72 months, no patient showed recurrence.
  
  
  CONCLUSIONS
  FH should be distinguished from other forms of fibromatosis and malignant tumors because it is benign and usually cured by local excision.
authors: Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors: Guhyun
authors: G
authors: Kang
authors: Yeon-Lim
authors: YL
authors: Suh
authors: Joungho
authors: J
authors: Han
authors: Gee-Young
authors: GY
authors: Kwon
authors: Suk-Koo
authors: SK
authors: Lee
authors: Jeong Meen
authors: JM
authors: Seo