title: Aging-associated B7-DC+ B cells enhance anti-tumor immunity via Th1 and Th17 induction.
abstract: Because most patients with cancer are aged and because immunological functions are altered during aging, it is important to account for aging-associated immunological alterations in the design of new cancer immunotherapies. We thus compared immune populations in young and aged mice and found that B7-DC(+) (PD-L2/CD273) B cells, a minor population in young mice, were significantly increased in aged mice. Induction of both Th1 and Th17 cells was significantly augmented by B7-DC(+) B cells from aged mice, and this effect was blocked with anti-B7-DC antibodies in vitro and in vivo. Moreover, retardation of tumor growth in aged mice was largely B7-DC dependent. Tumor growth in young mice was significantly inhibited by immunization with B7-DC(+) B cells from aged mice owing to increased induction of tumor antigen-specific cytotoxic T lymphocytes. These data indicate that B7-DC(+) B cells could play an important role in aging-associated cancer immunopathology as well as in other aging-associated diseases and further suggest that B7-DC(+) B cells have potential for future cancer immunotherapy.
authors: Cancer Therapy and Research Center, San Antonio, TX 78229, USA.
authors: Kei
authors: K
authors: Tomihara
authors: Takako
authors: T
authors: Shin
authors: Vincent J
authors: VJ
authors: Hurez
authors: Hideo
authors: H
authors: Yagita
authors: Drew M
authors: DM
authors: Pardoll
authors: Bin
authors: B
authors: Zhang
authors: Tyler J
authors: TJ
authors: Curiel
authors: Tahiro
authors: T
authors: Shin
mesh_terms: D000375:Aging / Q000276:immunology*; D000818:Animals; D057134:Antibodies, Neutralizing / Q000008:administration & dosage; D000951:Antigens, Neoplasm / Q000276:immunology; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D049109:Cell Proliferation; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology; D005434:Flow Cytometry; D006801:Humans; D008546:Melanoma, Experimental / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D061027:Programmed Cell Death 1 Ligand 2 Protein / Q000096:biosynthesis / Q000276:immunology*; D013154:Spleen / Q000276:immunology* / Q000473:pathology; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology / Q000276:immunology; D018417:Th1 Cells / Q000166:cytology / Q000276:immunology*; D058504:Th17 Cells / Q000166:cytology / Q000276:immunology*; D023041:Xenograft Model Antitumor Assays
chemical_list: D057134:Antibodies, Neutralizing; D000951:Antigens, Neoplasm; D016207:Cytokines; D061027:Programmed Cell Death 1 Ligand 2 Protein