title: ALOX5AP genetic variants and risk of atherothrombotic stroke in the Taiwanese population.
abstract: We explored the role of variants of the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene as factors for atherothrombotic stroke (ATS). A HapMap-based haplotype-tagging single nucleotide polymorphism (htSNP) association study was conducted in an isolated Taiwanese population. Multivariate logistic regression analyses revealed that patients with the GG/CG genotype of rs4293222 and the AA/AG genotype of rs4360791 had a 1.61-fold (odds ratio [OR]=1.61; 95% confidence interval [CI]=1.02-2.56, p=0.042) and a 1.69-fold (OR=1.69; 95% CI=1.00-2.86, p=0.047) increased risk of ATS, compared with patients with the CC/GG genotype, respectively. The most common haplotype allele, GTA, was used as a reference when analyzing the association between the haplotypes related to rs4293222, rs10507391, rs12429692 and ATS. The combined frequencies of all minor variant alleles of the three selected htSNP were associated with a 44% decreased risk of ATS (OR=0.56; 95% CI=0.37-0.84, p=0.005). This study provides preliminary evidence suggesting that genetic polymorphisms of ALOX5AP are associated with ATS.
authors: Department of Neurology, Chang Gung Memorial Hospital at Chiayi, Chang Gung University, Taiwan.
authors: Jiann-Der
authors: JD
authors: Lee
authors: Tsong-Hai
authors: TH
authors: Lee
authors: Yen-Chu
authors: YC
authors: Huang
authors: Yeu-Jhy
authors: YJ
authors: Chang
authors: Chien-Hung
authors: CH
authors: Chang
authors: Huan-Lin
authors: HL
authors: Hsu
authors: Ya-Hui
authors: YH
authors: Lin
authors: Chih-Ying
authors: CY
authors: Wu
authors: Meng
authors: M
authors: Lee
authors: Ying-Chih
authors: YC
authors: Huang
authors: Shan-Jin
authors: SJ
authors: Ryu
authors: Kuang-Ming
authors: KM
authors: Hsiao
mesh_terms: D058927:5-Lipoxygenase-Activating Proteins / Q000235:genetics*; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D002545:Brain Ischemia / Q000235:genetics*; D017700:Embolism, Cholesterol / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012907:Smoking; D020521:Stroke / Q000235:genetics*; D013624:Taiwan
chemical_list: D058927:5-Lipoxygenase-Activating Proteins; C548592:ALOX5AP protein, human