title: Use of nonsteroidal anti-inflammatory drugs and survival following breast cancer diagnosis.
abstract: BACKGROUND
  While there is accumulating evidence that use of nonsteroidal anti-inflammatory drugs (NSAID) decreases breast cancer risk, little is known about the impact of NSAIDs on survival after breast cancer diagnosis.
  
  
  METHODS
  We assessed whether recent, prediagnostic NSAID use and lifetime cumulative aspirin use before diagnosis were associated with survival among 1,024 women with incident, primary, invasive breast cancer.
  
  
  RESULTS
  Recent prediagnostic use of aspirin, ibuprofen, and acetaminophen and lifetime use of aspirin up to diagnosis were not associated with either all-cause mortality or breast cancer-specific mortality. Neither dose nor frequency of use was associated with risk. Associations were not different for pre- and postmenopausal women.
  
  
  CONCLUSIONS
  In our data, prediagnostic NSAID use and lifetime cumulative aspirin use were not associated with breast cancer survival.
  
  
  CONCLUSIONS
  Our findings do not support a role of NSAIDs prior to diagnosis in breast cancer survival.
authors: Department of Social and Preventive Medicine, State University of New York at Buffalo, 265 Farber Hall, Buffalo, NY 14214, USA. yanlili@buffalo.edu
authors: Yanli
authors: Y
authors: Li
authors: Theodore M
authors: TM
authors: Brasky
authors: Jing
authors: J
authors: Nie
authors: Christine B
authors: CB
authors: Ambrosone
authors: Susan E
authors: SE
authors: McCann
authors: Peter G
authors: PG
authors: Shields
authors: Maurizio
authors: M
authors: Trevisan
authors: Stephen B
authors: SB
authors: Edge
authors: Jo L
authors: JL
authors: Freudenheim
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001943:Breast Neoplasms / Q000401:mortality* / Q000517:prevention & control; D005260:Female; D006801:Humans; D008875:Middle Aged; D009026:Mortality; D009518:New York / Q000453:epidemiology; D016016:Proportional Hazards Models; D012307:Risk Factors; D016019:Survival Analysis
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal