title: Guiding DNA methylation.
abstract: How DNA methyltransferases, with their limited target specificity, establish cell-type-specific epigenetic patterns is poorly understood. Schübeler and colleagues (Lienert et al., 2011) now show that methylation-determining regions (MDRs) within promoter regions are sufficient to recapitulate endogenous patterns and dynamics of DNA methylation.
authors: Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA. alexander_meissner@harvard.edu
authors: Alexander
authors: A
authors: Meissner