title: A role for quorum sensing in regulating innate immune responses mediated by Vibrio cholerae outer membrane vesicles (OMVs).
abstract: Outer membrane vesicles (OMVs) are released from many Gram-negative bacteria. OMVs interact with and are taken up by human cells. We and others have now showed that OMVs contain peptidoglycan, which is sensed mainly by the pattern-recognition receptor NOD1 in the cytoplasm of host cells. Vibrio cholerae is clinically important as one of the causative agents of severe dehydrating diarrhea in humans. We showed that non-O1 non-O139 V. cholerae (NOVC) strains of V. cholera produce OMVs. Of note, we revealed that NOVC can evade NOD1-mediated immune surveillance by the quorum sensing machinery. Here we review these recent findings and discuss the relevance for our understanding of bacterial infections and innate immune responses.
authors: Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany.
authors: Harald
authors: H
authors: Bielig
authors: Mitesh
authors: M
authors: Dongre
authors: Birte
authors: B
authors: Zurek
authors: Sun N
authors: SN
authors: Wai
authors: Thomas A
authors: TA
authors: Kufer
mesh_terms: D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D002771:Cholera / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D007113:Immunity, Innate; D053474:Nod1 Signaling Adaptor Protein / Q000235:genetics / Q000276:immunology; D053038:Quorum Sensing; D022142:Secretory Vesicles / Q000235:genetics / Q000378:metabolism*; D014734:Vibrio cholerae / Q000235:genetics / Q000502:physiology*
chemical_list: D001425:Bacterial Outer Membrane Proteins; D053474:Nod1 Signaling Adaptor Protein