title: Investigation of the toxic effect of a QDs heterojunction on the interactions between small molecules and plasma proteins by fluorescence and resonance light-scattering spectra.
abstract: The effect of a ZnO#ZnS QDs heterojunction (O#SQDs) on the binding affinities of flavonoid glycosides for bovine serum albumin (BSA) was investigated. The fluorescence intensities of BSA decreased remarkably with increasing concentration of O#SQDs. The magnitudes of the binding constants of flavonoid glycosides for BSA in the presence of O#SQDs were in the range of 10(5)-10(7) L mol(-1), and the number of binding sites per BSA (n) was determined as 1.24 ± 0.17. O#SQDs increased the affinities of flavonoid glycosides for BSA by about 2.96% to 114.68% depending on their structures. O#SQDs in blood will enhance the transportation of flavonoid glycosidegs in blood and improve their pharmacology effects. From this point, O#SQDs are a perfect candidate for flavonoid glycosides delivery applications.
authors: College of Life & Environment Science, Shanghai Normal University, 100 Guilin Rd, Shanghai, 200234, PR China. jianboxiao@yahoo.com
authors: Jianbo
authors: J
authors: Xiao
authors: Yaru
authors: Y
authors: Zhao
authors: Fangfang
authors: F
authors: Mao
authors: Jie
authors: J
authors: Liu
authors: Muxia
authors: M
authors: Wu
authors: Xibin
authors: X
authors: Yu
mesh_terms: D000818:Animals; D001665:Binding Sites; D002417:Cattle; D004337:Drug Carriers; D016503:Drug Delivery Systems / Q000379:methods; D005419:Flavonoids / Q000737:chemistry / Q000378:metabolism*; D005453:Fluorescence; D031541:Fluorescence Resonance Energy Transfer / Q000379:methods*; D006027:Glycosides / Q000737:chemistry / Q000378:metabolism*; D045663:Quantum Dots; D012542:Scattering, Radiation; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000378:metabolism*; D013440:Sulfides / Q000494:pharmacology* / Q000633:toxicity; D017967:Zinc Compounds / Q000494:pharmacology* / Q000633:toxicity; D015034:Zinc Oxide / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D004337:Drug Carriers; D005419:Flavonoids; D006027:Glycosides; D013440:Sulfides; D017967:Zinc Compounds; D012710:Serum Albumin, Bovine; C031238:zinc sulfide; D015034:Zinc Oxide