title: Electrochemical behavior of azithromycin at graphene and ionic liquid composite film modified electrode.
abstract: An electrochemical method has been successfully demonstrated for sensitive determination of azithromycin (Azi) with room temperature ionic liquid (IL) of 1-butyl-3-methylimidazolium hexafluorophosphate (BMIMPF(6)) - graphene (Gr) composite modified glassy carbon electrode (GCE). The cyclic voltammetric results indicate that Gr/IL/GCE can remarkably enhance electrocatalytic activity towards the oxidation of Azi in neutral solutions. Azi produce an anodic peak at about 0.82 V at this electrode. The electrocatalytic behavior was further exploited as a sensitive detection scheme for the Azi determination by differential-pulse voltammetry (DPV). Under optimized conditions, the concentration range and detection limit were 0.49-28.57 μg ml(-1) and 0.19 μg ml(-1) (S/N=3) respectively for Azi. The method was successfully applied assay of the drug in the pharmaceutical dosage forms.
authors: College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, PR China.
authors: Jin Yun
authors: JY
authors: Peng
authors: Chuan Tao
authors: CT
authors: Hou
authors: Xiao Xian
authors: XX
authors: Liu
authors: Hong Bo
authors: HB
authors: Li
authors: Xiao Ya
authors: XY
authors: Hu
mesh_terms: D017963:Azithromycin / Q000737:chemistry*; D055664:Electrochemical Techniques / Q000379:methods*; D006108:Graphite / Q000737:chemistry*; D017736:Ion-Selective Electrodes; D052578:Ionic Liquids / Q000737:chemistry*
chemical_list: D052578:Ionic Liquids; D006108:Graphite; D017963:Azithromycin