title: Association of TGF-beta1, IL-4 and IL-13 gene polymerphisms with asthma in a Chinese population.
abstract: BACKGROUND
  Asthma is a common respiratory disease caused by genetic and environmental factors. It has been suggested that TGF-beta1, IL-4 and IL-13 play important roles in asthma.
  
  
  OBJECTIVE
  We attempted to confirm the roles of TGF-beta1, IL-4 and IL-13 polymorphisms in asthma in a Chinese population.
  
  
  METHODS
  Five SNPs (rs1800469, rs2241712, rs2070874, rs20541 and rs1800925) in TGF-beta1, IL-4 and IL-13 were genotyped using the MassArray SNP genotyping system. Allelic and genotypic associations between these SNPs and asthma were evaluated using logistic regression analysis.
  
  
  RESULTS
  The CT genotype of rs1800469 and T allele of rs20541 were significantly associated with asthma. Among atopic subjects, the CT genotype of rs1800469 and GA genotype of rs2241712 decreased the risk of asthma, while the CC genotype of rs2070874 showed a decreasing trend of asthma risk with a borderline significance. No significant association was found between rs1800925 and asthma.
  
  
  CONCLUSIONS
  In the present study, we confirmed the association of rs1800469 in TGF-beta1 and rs20541 in IL-13 with asthma and found a trend toward association between rs2241712 in TGF-beta1 and rs2070874 in IL-4 with asthma among atopic subjects, suggesting TGF-beta1, IL-4 and IL-13 may be associated with the susceptibility and development of asthma in this Chinese population.
authors: School of Biotechnology, Southern Medical University, Guangzhou, China.
authors: Xue-Xi
authors: XX
authors: Yang
authors: Fen-Xia
authors: FX
authors: Li
authors: Ying-Shong
authors: YS
authors: Wu
authors: Dong
authors: D
authors: Wu
authors: Jia-Yu
authors: JY
authors: Tan
authors: Ming
authors: M
authors: Li
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001249:Asthma / Q000235:genetics*; D002681:China; D005260:Female; D005838:Genotype; D006801:Humans; D018793:Interleukin-13 / Q000235:genetics*; D015847:Interleukin-4 / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D020641:Polymorphism, Single Nucleotide; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
chemical_list: C508598:IL4 protein, human; D018793:Interleukin-13; D053773:Transforming Growth Factor beta1; D015847:Interleukin-4