title: Cancer-associated nummular loss of RPE: expanding the clinical spectrum of bilateral diffuse uveal melanocytic proliferation.
abstract: This report describes a case of cancer-associated nummular retinal pigment epithelium loss associated with uterine cancer. The patient had progressive visual loss despite treatment with plasmapheresis, intravenous immunoglobulin, and local injection of corticosteroids. Clinical deterioration was corroborated by extension of the areas of retinal pigment epithelium loss, progression of cataracts, and growth of pigmented choroidal and iris lesions. Previously published cases of cancer-associated nummular retinal pigment epithelium loss did not describe the presence of cataracts or uveal melanocytic lesions. This case expands the clinical spectrum of bilateral diffuse uveal melanocytic proliferation.
authors: Princess Margaret Hospital, 610 University Avenue, 18th Floor, M5G 2M9 Toronto, Ontario, Canada. edunavajas@gmail.com
authors: Eduardo V
authors: EV
authors: Navajas
authors: E Rand
authors: ER
authors: Simpson
authors: Hatem
authors: H
authors: Krema
authors: Dena S
authors: DS
authors: Hammoudi
authors: Daniel
authors: D
authors: Weisbrod
authors: Marcus
authors: M
authors: Bernardini
authors: Filiberto
authors: F
authors: Altomare
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D008544:Melanocytes / Q000473:pathology*; D008875:Middle Aged; D012164:Retinal Diseases / Q000473:pathology*; D055213:Retinal Pigment Epithelium / Q000473:pathology*; D014594:Uterine Neoplasms / Q000473:pathology*; D014603:Uveal Diseases / Q000473:pathology*