title: Anesthesia of growing pigs with tiletamine-zolazepam and reversal with flumazenil.
abstract: The aim of the present study was to evaluate the anesthetic and cardiorespiratory effects of tiletamine/zolazepam and the effect of flumazenil on the recovery from tiletamine/zolazepam anesthesia in the pig. Six Landrace and Yorkshire cross-bred pigs (three females and three males, 3-4 months old) weighing 35.8 ± 1.7 kg were used in this study. Pigs were given tiletamine/zolazepam intramuscularly at a dose of 4.4 mg kg(-1) (2.2 mg kg(-1) tiletamine and 2.2 mg kg(-1) zolazepam) of body weight. Twenty minutes after the administration of tiletamine/zolazem, the pigs were given saline solution (control, Group TZ) or given flumazenil intravenously at a dose of 0.08 mg kg(-1) of body weight (Group TZF). Anesthesia and recovery times, scores of anesthetic effects and cardiorespiratory variables were recorded for each pig. There was a significant difference between the duration of tiletamine/zolazepam anesthesia with and without the antagonist. Flumazenil significantly shortened the recovery time. A significant difference in blood gas variables was observed between the two groups. The anesthetic effects induced by tiletamine/zolazepam could be reversed successfully and safely by flumazenil alone. Therefore, flumazenil administration could be considered in cases in which quick recovery is required in pigs.
authors: Department of Veterinary Surgery, College of Veterinary Medicine, Research Center for Transgenic Cloned Pigs, Chungnam National University, Daejeon 305–764, Korea.
authors: Jae Y
authors: JY
authors: Lee
authors: Myung C
authors: MC
authors: Kim
mesh_terms: D000777:Anesthetics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000931:Antidotes / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D004338:Drug Combinations; D005260:Female; D005442:Flumazenil / Q000008:administration & dosage / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D013552:Swine; D013992:Tiletamine / Q000008:administration & dosage / Q000494:pharmacology*; D015041:Zolazepam / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000777:Anesthetics; D000931:Antidotes; D004338:Drug Combinations; C006131:tiletamine, zolazepam drug combination; D013992:Tiletamine; D005442:Flumazenil; D015041:Zolazepam