title: Failure of echinocandin therapy in the treatment of Candida glabrata chorioretinitis.
abstract: Echinocandins are commonly used as initial empiric therapy in cases of moderate to severe invasive candidiasis. The authors demonstrate that caution should be exercised in applying this approach in certain clinical situations. A case of Candida glabrata fungemia and associated chorioretinitis that was clinically resistant to therapy with micafungin but appeared to resolve with amphotericin B is presented. The authors then briefly review current issues regarding the diagnosis and treatment of C glabrata chorioretinitis.
authors: Division of Infectious Diseases, University of Tennessee Health Science Center, Memphis, 38163, USA. hosam272004@hotmail.com
authors: Hosam A
authors: HA
authors: Mousselli
authors: John
authors: J
authors: Norwood
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D041221:Candida glabrata / Q000302:isolation & purification*; D002177:Candidiasis / Q000150:complications / Q000188:drug therapy*; D002825:Chorioretinitis / Q000188:drug therapy / Q000382:microbiology*; D025141:Drug Resistance, Fungal; D054714:Echinocandins / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D055666:Lipopeptides / Q000627:therapeutic use*; D000077551:Micafungin; D017211:Treatment Failure
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077551:Micafungin