title: Neonatal follow-up of 995 consecutively born children after embryo biopsy for PGD.
abstract: BACKGROUND
  Outcome data on children born after assisted reproduction treatments are important for both patients and health-care providers. The objective of this study was to determine whether embryo biopsy as performed in PGD has an impact on the health of infants up to 2 months of age.
  
  
  METHODS
  A prospective comparative follow-up study of children born after PGD and children born after ICSI by collecting written reports and performing a physical examination at 2 months was performed. Auxological data at birth and physical findings up to 2 months of age were compared for 995 children consecutively live born after embryo biopsy (1994-2009) and for a control group of 1507 children born after ICSI with embryo transfer on Day 5.
  
  
  RESULTS
  No differences regarding mean term, prematurity (term <32 w and <37 w), mean birthweight, very low birthweight (<1500 g), perinatal death, major malformations and neonatal hospitalizations in singletons and multiples born following PGD versus ICSI were observed. Compared with ICSI, fewer multiples born following PGD presented a low birthweight (<2500 g) (P = 0.005).
  
  
  CONCLUSIONS
  Embryo biopsy for PGD does not introduce extra risk to the overall medical condition of newborn children. Multiples born following embryo biopsy appear to be at lower risk for low birthweight compared with multiples born following ICSI.
authors: Centre for Medical Genetics, UZ Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090, Brussels, Belgium. sonja.desmyttere@uzbrussel.be
authors: S
authors: S
authors: Desmyttere
authors: M
authors: M
authors: De Rycke
authors: C
authors: C
authors: Staessen
authors: I
authors: I
authors: Liebaers
authors: F
authors: F
authors: De Schrijver
authors: W
authors: W
authors: Verpoest
authors: P
authors: P
authors: Haentjens
authors: Maryse
authors: M
authors: Bonduelle
mesh_terms: D001706:Biopsy / Q000009:adverse effects* / Q000379:methods*; D001724:Birth Weight; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015999:Multivariate Analysis; D011247:Pregnancy; D011256:Pregnancy Outcome; D019836:Preimplantation Diagnosis / Q000009:adverse effects* / Q000379:methods*; D011446:Prospective Studies; D012306:Risk; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods