title: Costs and clinical outcome of neoadjuvant systemic chemotherapy followed by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in peritoneal carcinomatosis from gastric cancer.
abstract: BACKGROUND
  The costs for loco-regional treatment of peritoneal carcinomatosis from gastric cancer are not well investigated. The aims of this study were to evaluate the costs and clinical outcome of systemic chemotherapy followed by cytoreductive surgery and intraperitoneal chemotherapy compared to systemic chemotherapy only in patients with peritoneal carcinomatosis from gastric cancer.
  
  
  METHODS
  Ten patients were scheduled for systemic chemotherapy followed by loco-regional treatment. A reference group of 10 matched control patients treated with systemic chemotherapy only were used and both groups were evaluated with respect to clinical outcome and cost.
  
  
  RESULTS
  The mean overall cost in the loco-regional group was $145,700 (range $49,900-$487,800) and $59,300 (range $23,000-$94,800) for the control group. The mean overall survival for the loco-regional group was 17.4 months (range 6.0-34.3), and 11.1 months (range 0.1-24.2) for the systemic chemotherapy only group. The gain in life-years was 0.52 and in quality-adjusted life-years 0.49, leading to incremental cost per life-year and quality-adjusted life-years gained of $166,716 and $175,164, for loco-regional group compared to systemic chemotherapy.
  
  
  CONCLUSIONS
  Treatment of peritoneal carcinomatosis from gastric cancer is costly irrespective of treatment modality. If the survival benefit from adding loco-regional treatment to systemic chemotherapy indicated from this comparison is true, the incremental cost is considered high.
authors: Department of Surgical Sciences, Section of Surgery, Uppsala University, Sweden. bo.hultman@surgsci.uu.se
authors: Bo
authors: B
authors: Hultman
authors: Jonas
authors: J
authors: Lundkvist
authors: Bengt
authors: B
authors: Glimelius
authors: Peter
authors: P
authors: Nygren
authors: Haile
authors: H
authors: Mahteme
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000556:secondary / Q000628:therapy*; D003365:Costs and Cost Analysis; D013505:Digestive System Surgical Procedures / Q000191:economics* / Q000379:methods; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000191:economics*; D007274:Injections, Intraperitoneal; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000191:economics* / Q000379:methods; D010534:Peritoneal Neoplasms / Q000556:secondary / Q000628:therapy*; D013274:Stomach Neoplasms / Q000473:pathology*; D016896:Treatment Outcome