title: Synthesis, spectral and conformational studies of some N-arylsulfonyl-t(3)-isopropyl-r(2),c(6)-diarylpiperidin-4-ones.
abstract: A series of N-arylsulfonyl-t(3)-isopropyl-r(2),c(6)-diarylpiperidin-4-ones 1-8 were synthesized and characterized unambiguously by (1)H, (13)C NMR, 2D-COSY and HSQC NMR spectroscopy. The conformational preferences of 1-8 have been discussed on the basis of the coupling constants, and they suggest normal chair conformation with equatorial orientations of all the substituents in 1-8. The preferred conformation of aryl sulfonyl group at nitrogen and isopropyl group at C-3 was determined theoretically using density functional calculations.
authors: A
authors: A
authors: Manimekalai
authors: S
authors: S
authors: Sivakumar