title: Short-term vs long-term calcium hydroxide therapy after immediate tooth replantation: a histomorphometric study in monkey's teeth.
abstract: Endodontic treatment is an important step of tooth replantation protocols, but the ideal moment for definitive obturation of replanted teeth has not yet been established. In this study, a histomorphometric analysis was undertaken to evaluate the repair process on immediate replantation of monkey's teeth after calcium hydroxide (CH) therapy for 1 and 6 months followed by root canal filling with a CH-based sealer (Sealapex(®) ). The maxillary and mandibular lateral incisors of five female Cebus apella monkeys were extracted, kept in sterile saline for 15 min, replanted and splinted with stainless steel orthodontic wire and composite resin for 10 days. In Group I (control), definitive root canal filling was performed before tooth extraction. In Groups II and III, CH therapy started after removal of splint, and definitive root canal filling was performed 1 and 6 months later, respectively. The animals were euthanized 9 months after replantation, and specimens were processed for histomorphometric analysis. In all groups, epithelial attachment occurred at the cementoenamel junction or very close to this region; the areas of resorption on root surface had small extension and depth and were repaired by newly formed cementum; and the periodontal ligament was organized. Statistical analysis of the scores obtained for the histomorphometric parameters did not show any statistically significant difference (P = 0.1221) among the groups. The results suggests that when endodontic treatment is initiated 10 days after immediate replantation and an antibiotic regimen is associated, definitive root canal filling can be performed after a short-term CH therapy.
authors: Department of Surgery and Integrated Clinics, School of Dentistry of Araçatuba, Universidade Estadual Paulista, Rua José Bonifácio 1193, Araçatuba, Brazil. panzarin@foa.unesp.br
authors: Sônia Regina
authors: SR
authors: Panzarini
authors: Jéssica Lemos
authors: JL
authors: Gulinelli
authors: Célia T M H
authors: CT
authors: Saito
authors: Wilson Roberto
authors: WR
authors: Poi
authors: Celso Koogi
authors: CK
authors: Sonoda
authors: José
authors: J
authors: Américo de Oliveira
authors: Moriel Evangelista
authors: ME
authors: Melo
authors: Weglis Dyanne
authors: WD
authors: de Souza Gomes
mesh_terms: D000818:Animals; D002126:Calcium Hydroxide / Q000627:therapeutic use*; D002428:Cebus; D003739:Dental Cementum / Q000187:drug effects*; D005260:Female; D010513:Periodontal Ligament / Q000187:drug effects*; D012389:Root Canal Obturation / Q000379:methods*; D012391:Root Resorption / Q000517:prevention & control*; D013997:Time Factors; D014090:Tooth Replantation / Q000379:methods*
chemical_list: D002126:Calcium Hydroxide