title: Classical Ehlers-Danlos syndrome: clinical, Histological and ultrastructural aspects.
abstract: A 12-year-old boy with difficulty in wound healing and scars of unusual appearance was examined. Thin, shiny and protruding skin, characterizing pseudotumoral lesions, was observed on his knees and elbows. Loose joints and increased skin elasticity were also observed. Light microscopy showed rare collagen bundles and loosely dispersed collagen fibers. Irregularly distributed elastic tissue was observed, and transmission electron microscopy revealed disorganized collagen fibers. In cross sections under high magnifications, fibers of varying diameters could be seen, as well as an irregular fiber outline. Scanning electron microscopy of the dermis showed disorganized collagen fibers, which were rarely arranged in bundles. Isolated and crossed-over fibers were also found.
authors: Catholic University of Pelotas, Pelotas, RS, Brazil.
authors: Eduardo de Barros Coelho
authors: Ede B
authors: Bicca
authors: Fabiano Bonow de
authors: FB
authors: Almeida
authors: Giselle Martins
authors: GM
authors: Pinto
authors: Luis Antônio Suíta de
authors: LA
authors: Castro
authors: Hiram Larangeira de
authors: HL
authors: Almeida
mesh_terms: D002648:Child; D003094:Collagen / Q000648:ultrastructure; D004535:Ehlers-Danlos Syndrome / Q000473:pathology*; D006801:Humans; D008297:Male; D046529:Microscopy, Electron, Transmission; D012867:Skin / Q000648:ultrastructure*
chemical_list: D003094:Collagen