title: The hydrazide/hydrazone click reaction as a biomolecule labeling strategy for M(CO)3 (M = Re, (99m)Tc) radiopharmaceuticals.
abstract: Facile reactivity of hydrazides and aldehydes was explored as potential coupling partners for incorporation into M(CO)(3) (M = Re, (99m)Tc) based radiopharmaceuticals. Both 'click, then chelate' and 'prelabel, then click' synthetic routes produced identical products in high yields and lacked metal-hydrazide/-hydrazone interactions, highlighting the potential of this click strategy.
authors: Department of Chemistry, Washington State University, Pullman WA 99164, USA.
authors: Tanushree
authors: T
authors: Ganguly
authors: Benjamin B
authors: BB
authors: Kasten
authors: Dejan-Krešimir
authors: DK
authors: Bučar
authors: Leonard R
authors: LR
authors: MacGillivray
authors: Clifford E
authors: CE
authors: Berkman
authors: Paul D
authors: PD
authors: Benny
mesh_terms: D057930:Click Chemistry; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D006834:Hydrazines / Q000737:chemistry*; D006835:Hydrazones / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry*; D012211:Rhenium / Q000737:chemistry; D013667:Technetium / Q000737:chemistry
chemical_list: D056831:Coordination Complexes; D006834:Hydrazines; D006835:Hydrazones; D008670:Metals; D019275:Radiopharmaceuticals; D012211:Rhenium; D013667:Technetium