title: [Relationship between vitamin D receptor gene Fok I polymorphisms and benign prostatic hyperplasia complicated by histological prostatitis].
abstract: OBJECTIVE
  To investigate the relationship between vitamin D receptor (VDR) gene Fok I polymorphisms and BPH complicated by histological prostatitis (BPH + HP).
  
  
  METHODS
  We detected Fok I polymorphisms in the peripheral blood of 79 patients with BPH + HP and 81 controls with BPH only using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and analyzed the frequency distribution of the genotypes and alleles of the two groups of patients.
  
  
  RESULTS
  Obvious differences were found in the distribution of genotypes and alleles between the BPH + HP patients (FF: 27% [21/79], Ff: 30% [24/79], ff: 43% [34/79]) and the controls (FF: 33% [27/81], Ff: 36% [29/81], ff: 31% [25/81]), with statistical significance in the distribution of the genotype ff (P < 0.05). The histological prostatitis group showed a significant difference from the controls in the frequency of the f allele (58% [196/338] vs 49% [153/312], P < 0.05), but not in that of the F allele (42% [142/338] vs 51% [159/312] , P > 0.05).
  
  
  CONCLUSIONS
  VDR Fok I polymorphisms may be correlated with BPH complicated by histological prostatitis.
authors: Graduate School, South Medical University, Guangzhou, Guangdong 510515, China. ruanli1978@126.com
authors: Li
authors: L
authors: Ruan
authors: Wei-de
authors: WD
authors: Zhong
authors: Zheng-ming
authors: ZM
authors: Li
authors: Xing
authors: X
authors: Hua
mesh_terms: D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011470:Prostatic Hyperplasia / Q000150:complications / Q000235:genetics*; D011472:Prostatitis / Q000150:complications / Q000235:genetics*; D018167:Receptors, Calcitriol / Q000235:genetics*
chemical_list: D018167:Receptors, Calcitriol