title: Structural magnetic resonance imaging in eating disorders: a systematic review of voxel-based morphometry studies.
abstract: This systematic review summarises and critically appraises the literature on structural magnetic resonance imaging in people with a current or past eating disorder. Studies using voxel-based morphometry image analysis were included. Ten studies reported on a total of 236 people with a current or past eating disorder and 257 healthy controls. Sample heterogeneity prohibited a meta-analytic approach. The findings do not unequivocally indicate grey or white matter volume abnormalities in people with an eating disorder. Nevertheless, these preliminary data suggest that, compared with healthy controls, people with anorexia nervosa have decreased grey matter in a range of brain regions and that those with bulimia nervosa have increased grey matter volumes in frontal and ventral striatal areas. Research in the recovery phase and longitudinal studies suggest that potential brain tissue abnormalities may recover with clinical improvement. Overall, as the available data are inconclusive, further efforts in this field are warranted.
authors: King's College London, Institute of Psychiatry, Department of Psychological Medicine, Section of Eating Disorders, London, UK. frederique.van_den_eynde@kcl.ac.uk
authors: Frederique
authors: F
authors: Van den Eynde
authors: Masashi
authors: M
authors: Suda
authors: Hannah
authors: H
authors: Broadbent
authors: Sébastien
authors: S
authors: Guillaume
authors: Magali
authors: M
authors: Van den Eynde
authors: Howard
authors: H
authors: Steiger
authors: Mimi
authors: M
authors: Israel
authors: Marcelo
authors: M
authors: Berlim
authors: Vincent
authors: V
authors: Giampietro
authors: Andrew
authors: A
authors: Simmons
authors: Janet
authors: J
authors: Treasure
authors: Iain
authors: I
authors: Campbell
authors: Ulrike
authors: U
authors: Schmidt
mesh_terms: D000856:Anorexia Nervosa / Q000473:pathology; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping / Q000379:methods; D052018:Bulimia Nervosa / Q000473:pathology; D001068:Feeding and Eating Disorders / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000379:methods*