title: Nocardia transvalensis keratitis: an emerging pathology among travelers returning from Asia.
abstract: BACKGROUND
  The incidence rate of Nocardia keratitis is increasing, with new species identified thanks to molecular methods. We herein report a case of Nocardia transvalensis keratitis, illustrating this emerging pathology among travellers returning from Asia.
  
  
  METHODS
  A 23-year-old man presented with a 10-week history of ocular pain, redness, and blurred vision in his right eye following a projectile foreign body impacting the cornea while motor biking in Thaïland. At presentation, a central epithelial defect with a central whitish stromal infiltrate associated with pinhead satellite infiltrates was observed. Identification with 16S rRNA PCR sequencing and microbiological culture of corneal scraping and revealed N. transvalensis as the causative organism. Treatment was initiated with intensive topical amikacin, oral ketoconazole and oral doxycycline. After a four-week treatment period, the corneal infiltrate decreased so that only a faint subepithelial opacity remained.
  
  
  CONCLUSIONS
  Nocardia organisms should be suspected as the causative agent of any case of keratitis in travelers returning from Asia. With appropriate therapy, Nocardia keratitis resolves, resulting in good visual outcome.
authors: Service d'ophtalmologie, Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
authors: Elodie
authors: E
authors: Trichet
authors: Stéphan
authors: S
authors: Cohen-Bacrie
authors: John
authors: J
authors: Conrath
authors: Michel
authors: M
authors: Drancourt
authors: Louis
authors: L
authors: Hoffart
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000583:Amikacin / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage; D021821:Communicable Diseases, Emerging / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology; D003315:Cornea / Q000473:pathology; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D004318:Doxycycline / Q000008:administration & dosage; D005547:Foreign Bodies / Q000150:complications; D006801:Humans; D015994:Incidence; D007634:Keratitis / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology; D007654:Ketoconazole / Q000008:administration & dosage; D008297:Male; D008969:Molecular Sequence Data; D009615:Nocardia / Q000302:isolation & purification*; D009617:Nocardia Infections / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D017422:Sequence Analysis, DNA; D013785:Thailand; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D004269:DNA, Bacterial; D004275:DNA, Ribosomal; D012336:RNA, Ribosomal, 16S; D000583:Amikacin; D004318:Doxycycline; D007654:Ketoconazole