title: Stem cell models for biomarker discovery in brain disease.
abstract: Most brain diseases arise from interactions between complex genetic and environmental risk factors. Finding biomarkers for brain diseases will require appropriate cellular models to identify dysregulated cell functions and disease-associated biochemistries. Patient-derived stem cells hold great potential as models of brain diseases. Stem cells can proliferate and can be banked, stored, and thawed for genomic, proteomic, and functional studies. Patient-derived, induced pluripotent stem cells and adult stem cells from the olfactory organ in the nose are already giving novel insights into a number of brain diseases, including Parkinson's disease and schizophrenia. Biomarker discovery may be possible from investigating disease-associated cell biologies in patient-derived stem cells.
authors: National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia.
authors: Alan
authors: A
authors: Mackay-Sim
authors: George
authors: G
authors: Mellick
authors: Stephen
authors: S
authors: Wood
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis* / Q000378:metabolism*; D001927:Brain Diseases / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology*; D018929:Cell Culture Techniques / Q000379:methods; D004195:Disease Models, Animal; D006801:Humans; D008967:Molecular Biology / Q000379:methods / Q000639:trends; D025202:Molecular Diagnostic Techniques / Q000379:methods / Q000639:trends; D013234:Stem Cells / Q000378:metabolism* / Q000473:pathology*
chemical_list: D015415:Biomarkers