title: Dynamic nuclear polarization: new methodology and applications.
abstract: One way to overcome the intrinsically low sensitivity of Nuclear Magnetic Resonance spectroscopy is to enhance the signal by dynamic nuclear polarization (DNP), where the polarization of high-gyromagnetic ratio (γ) electrons is transferred to the surrounding nuclei using microwave (MW) irradiation. Recent developments in DNP instrumentations and applications have shown that DNP is one of the most effective methods to increase the nuclear spin polarization in inorganic, organic, and biological materials. It is possible to obtain a solution of molecules containing hyperpolarized nuclei in combination with methods to dissolve rapidly the polarized solid sample. In this chapter, a brief introduction on a theoretical basis and some of new DNP applications in NMR spectroscopy as well as medical applications in Magnetic Resonance Imaging (MRI) are described.
authors: Department of Microbiology, The University of Hong Kong, Hong Kong, China. khsze@hku.hk
authors: Kong Hung
authors: KH
authors: Sze
authors: Qinglin
authors: Q
authors: Wu
authors: Ho Sum
authors: HS
authors: Tse
authors: Guang
authors: G
authors: Zhu
mesh_terms: D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008872:Microwaves; D019906:Nuclear Magnetic Resonance, Biomolecular