title: [Experimental research regarding the influence of the stress factors in an animal model of HELLP syndrome].
abstract: OBJECTIVE
  to study the effects of licht/dark induced-stress in an animal model of HELLP syndrome.
  
  
  METHODS
  The experiment was carried out on white female Wistar rats treated intraperitoneally, for 4 weeks, as follows: Group 1: saline solution 0.5ml/100g weight; Group 2: saline solution + dark induced-stress, continuously, 28 days; Group 3: saline solution + light induced-stress, continuously, 28 days; Group 4: endotelin-l; Group 5: endotelin-1 + dark induced-stress, continuously, 28 days; Group 6: endotelin-1 + light induced-stress, continuously, 28 days. Endotelin-1 0.125nmol/kbw was initially administered, followed by 0.25nmol/kbw 30 min later, 2 times/week.
  
  
  RESULTS
  At the end of the experiment blood pressure was measured and blood samples were taken to assess: leukocyte formula, phagocytic capacity of peripheral neutrophils and serum complement activity, aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT) and lactic dehydrogenase (LDH) activity, total bilirubin and lipid profile.
  
  
  CONCLUSIONS
  In these experimental conditions we obtained an animal model of partial HELLP syndrome (elevated liver enzyme levels and a low platelet count, values emphasized by light induced-stress, without hemolysis). In chronically stressed animals we found the highest levels of blood pressure, a decrease of plasmatic cortisol level and of phagocytic capacity of peripheral neutrophils and an increase of total cholesterol.
authors: Universitatea de Medicină şi Farmacie "Gr. T. Popa" Iaşi, Facultatea de Medicină.
authors: Minodora
authors: M
authors: Diaconu
authors: C
authors: C
authors: Diaconu
authors: Liliana
authors: L
authors: Tarţău
authors: Cătălina-Elena
authors: CE
authors: Lupuşoru
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D001794:Blood Pressure; D003165:Complement System Proteins / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D017359:HELLP Syndrome / Q000097:blood* / Q000209:etiology; D006854:Hydrocortisone / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007958:Leukocyte Count; D008027:Light; D008055:Lipids / Q000097:blood; D009504:Neutrophils; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological; D013315:Stress, Psychological
chemical_list: D015415:Biomarkers; D008055:Lipids; D003165:Complement System Proteins; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin; D006854:Hydrocortisone