title: Replication of five prostate cancer loci identified in an Asian population--results from the NCI Breast and Prostate Cancer Cohort Consortium (BPC3).
abstract: BACKGROUND
  A recent genome-wide association study (GWAS) of prostate cancer in a Japanese population identified five novel regions not previously discovered in other ethnicities. In this study, we attempt to replicate these five loci in a series of nested prostate cancer case-control studies of European ancestry.
  
  
  METHODS
  We genotyped five single-nucleotide polymorphism (SNP): rs13385191 (chromosome 2p24), rs12653946 (5p15), rs1983891 (6p21), rs339331 (6p22), and rs9600079 (13q22), in 7,956 prostate cancer cases and 8,148 controls from a series of nested case-control studies within the National cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3). We tested each SNP for association with prostate cancer risk and assessed whether associations differed with respect to disease severity and age of onset.
  
  
  RESULTS
  Four SNPs (rs13385191, rs12653946, rs1983891, and rs339331) were significantly associated with prostate cancer risk (P values ranging from 0.01 to 1.1 × 10(-5)). Allele frequencies and ORs were overall lower in our population of European descent than in the discovery Asian population. SNP rs13385191 (C2orf43) was only associated with low-stage disease (P = 0.009, case-only test). No other SNP showed association with disease severity or age of onset. We did not replicate the 13q22 SNP, rs9600079 (P = 0.62).
  
  
  CONCLUSIONS
  Four SNPs associated with prostate cancer risk in an Asian population are also associated with prostate cancer risk in men of European descent.
  
  
  CONCLUSIONS
  This study illustrates the importance of evaluation of prostate cancer risk markers across ethnic groups.
authors: Department of Epidemiology, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA. slindstr@hsph.harvard.edu
authors: Sara
authors: S
authors: Lindström
authors: Fredrick R
authors: FR
authors: Schumacher
authors: Daniele
authors: D
authors: Campa
authors: Demetrius
authors: D
authors: Albanes
authors: Gerald
authors: G
authors: Andriole
authors: Sonja I
authors: SI
authors: Berndt
authors: H Bas
authors: HB
authors: Bueno-de-Mesquita
authors: Stephen J
authors: SJ
authors: Chanock
authors: W Ryan
authors: WR
authors: Diver
authors: J Michael
authors: JM
authors: Ganziano
authors: Susan M
authors: SM
authors: Gapstur
authors: Edward
authors: E
authors: Giovannucci
authors: Christopher A
authors: CA
authors: Haiman
authors: Brian
authors: B
authors: Henderson
authors: David J
authors: DJ
authors: Hunter
authors: Mattias
authors: M
authors: Johansson
authors: Laurence N
authors: LN
authors: Kolonel
authors: Loic
authors: L
authors: Le Marchand
authors: Jing
authors: J
authors: Ma
authors: Meir
authors: M
authors: Stampfer
authors: Victoria L
authors: VL
authors: Stevens
authors: Dimitrios
authors: D
authors: Trichopoulos
authors: Jarmo
authors: J
authors: Virtamo
authors: Walter C
authors: WC
authors: Willett
authors: Meredith
authors: M
authors: Yeager
authors: Ann W
authors: AW
authors: Hsing
authors: Peter
authors: P
authors: Kraft
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D005060:Europe / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics* / Q000473:pathology