title: Development of a novel, nearly insoluble antiadhesive membrane.
abstract: BACKGROUND
  Sodium hyaluronate/carboxymethylcellulose (HA/CMC) is difficult to use in a moist environment because of its susceptibility to moisture.
  
  
  METHODS
  We developed the three-layered nDM-14R membrane. The surface layers are composed of 1-lactide, glycolide and e-caprolactone copolymers. HA/CMC and nDM-14R were used in all these studies. (1) The central region of 1 × 10 cm specimens (n = 5) was moistened for 0, 5, 10, 20, 30 or 60 s, after which the tensile strength was determined; (2) one side of specimens of 1 × 10 cm (n = 5) was moistened with agar gel for 5, 10, 15 or 30 s, after which the adhesion strength was determined, and (3) Rat cecum (n = 10) was scratched, 3 × 3 cm specimens were placed on the scratched area, and adhesions were evaluated on postoperative day 14.
  
  
  CONCLUSIONS
  (1) The tensile strength of nDM-14R after contact for 10-30 s was greater than that of HA/CMC. (2) The adhesive strength of HA/CMC after contact for 5-10 s was greater than that of nDM-14R. (3) Adhesion scores in treatment groups were significantly lower than in the control group. The results suggest that nDM-14R has the same antiadhesive effect and allows easier placement under moist conditions than HA/CMC.
authors: Department of Surgery, Shiga University of Medical Science, Ohtsu, Japan.
authors: T
authors: T
authors: Mukai
authors: S
authors: S
authors: Kamitani
authors: T
authors: T
authors: Shimizu
authors: M
authors: M
authors: Fujino
authors: Y
authors: Y
authors: Tsutamoto
authors: Y
authors: Y
authors: Endo
authors: K
authors: K
authors: Hanasawa
authors: T
authors: T
authors: Tani
mesh_terms: D000818:Animals; D008422:Materials Testing; D008567:Membranes, Artificial; D011183:Postoperative Complications / Q000517:prevention & control*; D051381:Rats; D012995:Solubility; D013718:Tensile Strength; D000267:Tissue Adhesions / Q000517:prevention & control*
chemical_list: D008567:Membranes, Artificial