title: Diversity-oriented optical imaging probe development.
abstract: The development of optical probes is receiving considerable attention due to their rising adaptation in diagnostics and medical imaging. Diversity-oriented approaches make use of combinatorial chemistry and high-throughput screenings to enrich the spectral and structural variety of these probes and effectively identify those with specific properties (e.g. molecular affinity, cellular selectivity, high photostability, and sensitivity). Herein we review recent examples in which diversity-driven strategies have assisted the discovery of new molecular imaging probes.
authors: Biomolecules Function Research Center, Future Convergence Research Division, Korea Institute of Science and Technology, 136-791, South Korea.
authors: Jun-Seok
authors: JS
authors: Lee
authors: Marc
authors: M
authors: Vendrell
authors: Young-Tae
authors: YT
authors: Chang
mesh_terms: D020650:Combinatorial Chemistry Techniques; D005456:Fluorescent Dyes / Q000032:analysis / Q000138:chemical synthesis* / Q000378:metabolism; D049452:Green Fluorescent Proteins / Q000032:analysis; D057166:High-Throughput Screening Assays; D057054:Molecular Imaging / Q000379:methods*; D015335:Molecular Probes / Q000032:analysis / Q000138:chemical synthesis* / Q000378:metabolism; D013194:Staining and Labeling / Q000379:methods*
chemical_list: D005456:Fluorescent Dyes; D015335:Molecular Probes; D049452:Green Fluorescent Proteins