title: [Eosinophilic myocarditis and sudden unexpected death in a younger patient treated with antipsychotics].
abstract: A 36 year-old man suffering from schizophrenia was found dead in his apartment. Forensic autopsy was performed due to sudden unexpected death but did not yield the cause of death. Histological examination of the heart showed eosinophilic myocarditis (EM) while forensic chemistry showed a raised level of aripripazol. We discuss the risk of sudden cardiac death in patients receiving antipsychotic drugs and the possible connection between raised drug levels and EM, and we emphasise the importance of autopsy and hope for better means in the future of finding patients at risk.
authors: Retspatologisk Afdeling, Retsmedicinsk Institut, Aarhus Universitet, 8200 Aarhus N, Denmark. rikkekch@hotmail.com
authors: Rikke Kjærgaard
authors: RK
authors: Christoffersen
authors: Lone Due
authors: LD
authors: Vestergård
authors: Lene
authors: L
authors: Høimark
authors: Annie
authors: A
authors: Vesterby
mesh_terms: D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects / Q000097:blood; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000097:blood; D000068180:Aripiprazole; D001344:Autopsy; D001569:Benzodiazepines / Q000009:adverse effects / Q000097:blood; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D004359:Drug Therapy, Combination; D004802:Eosinophilia / Q000139:chemically induced* / Q000150:complications / Q000473:pathology; D049429:Forensic Pathology; D053593:Forensic Toxicology; D006801:Humans; D008297:Male; D008803:Mianserin / Q000009:adverse effects / Q000031:analogs & derivatives / Q000097:blood; D000078785:Mirtazapine; D009205:Myocarditis / Q000139:chemically induced* / Q000150:complications / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D000077152:Olanzapine; D010879:Piperazines / Q000009:adverse effects* / Q000097:blood; D015363:Quinolones / Q000009:adverse effects* / Q000097:blood; D012307:Risk Factors
chemical_list: D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D010879:Piperazines; D015363:Quinolones; D001569:Benzodiazepines; D008803:Mianserin; D000068180:Aripiprazole; D000078785:Mirtazapine; D000077152:Olanzapine