title: Comparison of autophotomontage software programs in eyes with CMV retinitis.
abstract: OBJECTIVE
  Automated mosaic software programs are used to stitch together overlapping retinal fundus photographs. The performance of these programs in eyes with retinal diseases has not been independently evaluated. This study compares the quality of the mosaic products of three autophotomontage software programs, using digital fundus photographs of eyes with cytomegalovirus (CMV) retinitis.
  
  
  METHODS
  Photographs of 99 eyes with CMV retinitis of 94 patients with HIV were taken at Maharaj Nakorn Chiang Mai Hospital in Chiang Mai, Thailand. Automated mosaic images were created for each of the 99 eyes by three different commercially available programs: IMAGEnet (Topcon, Oakland, NJ), i2k Retina (DualAlign LLC, Clifton Park, NY), and AutoMontage (OIS, Sacramento, CA). Three masked graders ranked each set of mosaics for each eye. The graders also assessed the overall image quality and documented mosaic artifacts in each image.
  
  
  RESULTS
  i2k Retina was ranked as the best program (70%-88%) more often than AutoMontage (10%-33%, P < 0.001) or IMAGEnet (0%-4%, P < 0.001) for creating automontages from digital fundus photographs of eyes with CMV retinitis. Acceptable quality mosaic images were reported most commonly for i2k Retina (93%-94%) and AutoMontage (91%-95%), followed by IMAGEnet (27%-56%, P < 0.001). IMAGEnet had a significantly higher percentage of mosaic errors than did either i2k Retina or AutoMontage (P < 0.001).
  
  
  CONCLUSIONS
  In eyes with CMV retinitis, both the i2k Retina and AutoMontage software packages appear to create higher quality mosaics than does IMAGEnet. Automated retinal mosaic imaging may be valuable in diagnosing CMV retinitis and observing disease progression.
authors: F. I. Proctor Foundation, San Francisco, California, USA.
authors: Jenny
authors: J
authors: Chen
authors: Somsanguan
authors: S
authors: Ausayakhun
authors: Sakarin
authors: S
authors: Ausayakhun
authors: Choeng
authors: C
authors: Jirawison
authors: Claire M
authors: CM
authors: Khouri
authors: Travis C
authors: TC
authors: Porco
authors: David
authors: D
authors: Heiden
authors: Jeremy D
authors: JD
authors: Keenan
authors: Todd P
authors: TP
authors: Margolis
mesh_terms: D017726:Cytomegalovirus Retinitis / Q000175:diagnosis*; D018450:Disease Progression; D001330:Electronic Data Processing / Q000295:instrumentation*; D006801:Humans; D010781:Photography / Q000379:methods*; D011446:Prospective Studies; D012372:ROC Curve; D015203:Reproducibility of Results; D012160:Retina / Q000473:pathology*; D012984:Software; D012985:Software Design