title: Synthesis and structure-activity study of quaternary ammonium functionalized beta-cyclodextrin-carboxymethylcellulose polymers.
abstract: Carboxymethylcellulose (CMC) and beta-cyclodextrin (beta-CD)-based polymers functionalized with two types of quaternary ammonium compounds (QACs), the alkaquat DMB-451 (N-alkyl (50% C14, 40% C12, 10% C10) dimethylbenzylammonium chloride) (DMD-451) named polymer DMB-451, and FMB 1210-8 (a blend of 32 w% N-alkyl (50% C14, 40% C12, 10% C10) dimethylbenzylammonium chloride and 48 w% of didecyldimethylammonium chloride) named polymer FMB 1210-8, were synthethized and characterized by Fourier transform infrared spectroscopy. The antimicrobial activities of these polymers against Eschericia coli were also evaluated at 25 degrees C in wastewater. The results have indicated that the polymer FMB 1210-8 possesses a high-affinity binding with bacterial cells that induces a rapid disinfection process. Moreover, in the same experimental conditions of disinfection (mixture of 1.0 g of polymer and 100 mL of wastewater), the polymer FMB 1210-8 has a higher antimicrobial efficiency (99.90%) than polymer DMB-451 (92.8%). This phenomenon might be associated to a stronger interaction with bacterial cells due to stronger binding affinity for E. coli cells and greater killing efficiency of the C10 alkyl chains QAC of polymer FMB 1210-8 to disrupt the bacterial cell membrane as compared to N-alkyl (50% C14, 40% C12, 10% C10) dimethylbenzylammonium chloride. Together, these results suggest that the polymer FMB 1210-8 could constitute a good disinfectant against Escherichia coli, which could be advantageously used in wastewater treatments due to the low toxicity of beta-CD and CMC, and moderated toxicity of FMB 1210-8 to human and environment.
authors: Département de génie de la construction, STEPPE-Ecole de technologie supérieure, 1100, Notre-Dame Ouest, Montréal, QC, Canada H3C 1K3.
authors: Danielle
authors: D
authors: Bonenfant
authors: François-René
authors: FR
authors: Bourgeois
authors: Murielle
authors: M
authors: Mimeault
authors: Frédéric
authors: F
authors: Monette
authors: Patrick
authors: P
authors: Niquette
authors: Robert
authors: R
authors: Hausler
mesh_terms: D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D004202:Disinfectants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D005374:Filtration; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013329:Structure-Activity Relationship; D018508:Water Purification / Q000379:methods*; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D004202:Disinfectants; D011108:Polymers; D000644:Quaternary Ammonium Compounds; D047392:beta-Cyclodextrins; C031215:betadex; D002266:Carboxymethylcellulose Sodium