title: Synthesis and in vitro evaluation of analogues of avocado-produced toxin (+)-(R)-persin in human breast cancer cells.
abstract: A structure-activity study of several new synthetic analogues of the avocado-produced toxin persin has been conducted, with compounds being evaluated for their cytostatic and pro-apoptotic effects in human breast cancer cells. A 4-pyridinyl derivative demonstrated activity comparable to that of the natural product, suggesting future directions for exploration of structure-activity relationships.
authors: Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. d.brooke@auckland.ac.nz
authors: Darby G
authors: DG
authors: Brooke
authors: Elizabeth J
authors: EJ
authors: Shelley
authors: Caroline G
authors: CG
authors: Roberts
authors: William A
authors: WA
authors: Denny
authors: Robert L
authors: RL
authors: Sutherland
authors: Alison J
authors: AJ
authors: Butt
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D045744:Cell Line, Tumor; D005233:Fatty Alcohols / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D005260:Female; D006801:Humans; D027421:Persea / Q000737:chemistry*; D010936:Plant Extracts / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005233:Fatty Alcohols; D010936:Plant Extracts; C098164:persin