title: The effects of chronic periodontitis and rheumatoid arthritis on serum and gingival crevicular fluid total antioxidant/oxidant status and oxidative stress index.
abstract: BACKGROUND
  Chronic periodontitis (CP) and rheumatoid arthritis (RA) appear to share many pathologic features. Oxygen metabolism has an important role in the pathogenesis of both CP and RA. The aim of this study is to evaluate the relationship between these two chronic inflammatory diseases with regard to antioxidant and oxidant status.
  
  
  METHODS
  A total of 80 participants were divided into four groups of 20 each: group RA-CP (patients with RA and CP), group RA (periodontally healthy patients with RA), group CP (systemically healthy patients with CP), and group C (periodontally and systemically healthy volunteers) were included in the study. After assessment of periodontal measurements, gingival crevicular fluid (GCF) samples were taken at one incisor, premolar, and molar tooth and stored with serum samples at -80°C for the antioxidant/oxidant assay.
  
  
  RESULTS
  Although all clinical measurements in groups RA-CP and CP were statistically higher compared to those of C and RA groups (P <0.001), there were no differences between CP and RA-CP groups (P >0.05). GCF total oxidant status (TOS) values of CP and RA-CP groups were higher than those of the RA group (P <0.05). GCF oxidative stress index (OSI) values of the RA-CP group were higher than those of the RA group (P <0.05). There were no differences among the groups in terms of serum TOS and OSI values (P >0.05).
  
  
  CONCLUSIONS
  Local OSI values in groups with patients with CP were higher, whereas systemic OSI values showed no difference among the groups. The presence of RA seems not to affect local and systemic OSI values in patients with CP.
authors: Department of Periodontology, Faculty of Dentistry, Erciyes University, Kayseri, Turkey. cagriesen@hotmail.com
authors: Cağrı
authors: C
authors: Esen
authors: Banu Arzu
authors: BA
authors: Alkan
authors: Mehmet
authors: M
authors: Kırnap
authors: Ozgür
authors: O
authors: Akgül
authors: Semra
authors: S
authors: Işıkoğlu
authors: Ozcan
authors: O
authors: Erel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000032:analysis*; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000145:classification / Q000378:metabolism; D055113:Chronic Periodontitis / Q000097:blood* / Q000378:metabolism; D003774:Dental Plaque Index; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D005884:Gingival Hemorrhage / Q000145:classification; D006801:Humans; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000737:chemistry*; D018384:Oxidative Stress / Q000502:physiology*; D017622:Periodontal Attachment Loss / Q000097:blood; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000145:classification; D016059:Range of Motion, Articular / Q000502:physiology; D017382:Reactive Oxygen Species / Q000032:analysis / Q000097:blood; D055815:Young Adult
chemical_list: D000975:Antioxidants; D016877:Oxidants; D017382:Reactive Oxygen Species