title: Three-year follow-up of sirolimus-eluting stents vs. bare metal stents for acute myocardial infarction.
abstract: BACKGROUND
  The long-term safety and efficacy of drug-eluting stents for patients with acute myocardial infarction (AMI) remain controversial.
  
  
  RESULTS
  A total of 143 consecutive patients who presented between August 2004 and July 2006 with AMI and who underwent primary percutaneous coronary intervention (PCI) using sirolimus-eluting stents (SES), were compared with a historical control cohort of 129 consecutive patients who presented between August 2002 and July 2004 and who underwent primary PCI using bare metal stents (BMS). The rate of major adverse cardiovascular events at 3 years was significantly lower in the SES group than in the BMS group (20.3% vs. 33.1%, respectively; P=0.01). This reduction was mainly driven by a decrease in the rate of target vessel revascularization (12.3% vs. 22.4%, respectively; P=0.02). There was no significant difference in the rate of cardiovascular death (4.5% vs. 5.7%, respectively; P=0.67), non-fatal myocardial infarction (4.5% vs. 9.2%, respectively; P=0.16), coronary artery bypass grafting (2.3% vs. 2.5%, respectively; P=0.93), stroke (2.4% vs. 0.8%, respectively; P=0.35), and stent thrombosis (2.9% vs. 2.3%, respectively; P=0.80) between the 2 groups.
  
  
  CONCLUSIONS
  SES can be used safely and effectively in patients with AMI.
authors: Department of Cardiology, Hiroshima City Hospital, Hiroshima, Japan.
authors: Kentaro
authors: K
authors: Ejiri
authors: Masaharu
authors: M
authors: Ishihara
authors: Kazuoki
authors: K
authors: Dai
authors: Takashi
authors: T
authors: Miki
authors: Ichiro
authors: I
authors: Inoue
authors: Takuji
authors: T
authors: Kawagoe
authors: Yuji
authors: Y
authors: Shimatani
authors: Fumiharu
authors: F
authors: Miura
authors: Yasuharu
authors: Y
authors: Nakama
authors: Takayuki
authors: T
authors: Otani
authors: Hiroki
authors: H
authors: Ikenaga
authors: Nozomu
authors: N
authors: Oda
authors: Masayuki
authors: M
authors: Nakamura
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D002318:Cardiovascular Diseases / Q000401:mortality; D015331:Cohort Studies; D001026:Coronary Artery Bypass / Q000706:statistics & numerical data; D003328:Coronary Thrombosis / Q000453:epidemiology; D054855:Drug-Eluting Stents / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007564:Japan; D008137:Longitudinal Studies; D008297:Male; D008670:Metals; D008875:Middle Aged; D009203:Myocardial Infarction / Q000628:therapy*; D012189:Retrospective Studies; D020123:Sirolimus; D015607:Stents / Q000009:adverse effects; D020521:Stroke / Q000453:epidemiology; D016896:Treatment Outcome
chemical_list: D008670:Metals; D020123:Sirolimus