title: Serum levels of bone resorption markers are decreased in patients with type 2 diabetes.
abstract: Previous studies of bone turnover markers in diabetes are limited, and the results are conflicting. Our aim was to evaluate differences in bone turnover markers and i-PTH between T2DM and non-diabetes subjects. Cross-sectional study including 133 subjects (78 T2DM, 55 without diabetes). BMD were measured by dual X-ray absorptiometry. Bone turnover markers were determined in serum. Serum levels of bone resorption markers (CTX and TRAP5b) were lower in T2DM compared with non-diabetes subjects. There were no differences in bone formation markers. i-PTH serum levels were lower in T2DM: 38.35 ± 18.20 pg/ml versus 50.22 ± 18.99 pg/ml, P < 0.05. TRAP5b and CTX were positively correlated with i-PTH (CTX: r = 0.443, P < 0.001; TRAP5b: r = 0.180, P = 0.047). There was an inverse relationship between TRAP5b levels and diabetes duration (r = -0.269, P = 0.021). T2DM patients have lower levels of bone resorption markers, and i-PTH compared with subjects without diabetes. Lower levels of PTH may induce a low turnover state as reflected by lower levels of bone resorption markers, and this situation may influence the higher risk of fracture of T2DM.
authors: Bone Metabolic Unit, RETICEF, Endocrinology Division, Hospital Universitario San Cecilio, Granada, Spain.
authors: Rebeca
authors: R
authors: Reyes-García
authors: Pedro
authors: P
authors: Rozas-Moreno
authors: Gema
authors: G
authors: López-Gallardo
authors: Antonia
authors: A
authors: García-Martín
authors: Mariela
authors: M
authors: Varsavsky
authors: Maria Dolores
authors: MD
authors: Avilés-Perez
authors: Manuel
authors: M
authors: Muñoz-Torres
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D015519:Bone Density; D001862:Bone Resorption; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood
chemical_list: D015415:Biomarkers; D010281:Parathyroid Hormone