title: Label-free visual detection of nucleic acids in biological samples with single-base mismatch detection capability.
abstract: We have combined an allosteric molecular beacon for target recognition and guanine-rich DNAzyme for signal amplification to develop a new platform for visual detection of nucleic acids with single-base mismatch detection capability. The fully DNA-structured platform can undergo color change in response to target DNA/RNA, which enables sensitive and selective visual detection in biological samples.
authors: State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian, 361005, China.
authors: Yanling
authors: Y
authors: Song
authors: Weiting
authors: W
authors: Zhang
authors: Yuan
authors: Y
authors: An
authors: Liang
authors: L
authors: Cui
authors: Chundong
authors: C
authors: Yu
authors: Zhi
authors: Z
authors: Zhu
authors: Chaoyong James
authors: CJ
authors: Yang
mesh_terms: D020137:Base Pair Mismatch; D002460:Cell Line; D003124:Colorimetry / Q000379:methods*; D021881:DNA, Catalytic / Q000378:metabolism*; D006801:Humans; D009696:Nucleic Acids / Q000032:analysis*; D015345:Oligonucleotide Probes / Q000378:metabolism; D012680:Sensitivity and Specificity
chemical_list: D021881:DNA, Catalytic; D009696:Nucleic Acids; D015345:Oligonucleotide Probes