title: Benzenepolycarboxylic acids with potential anti-hemorrhagic properties and structure-activity relationships.
abstract: Previously, we reported the structural requirements of the cinnamic acid relatives for inhibition of snake venom hemorrhagic action. In the present study, we examined the effect of benzenepolycarboxylic acids and substituted benzoic acids against Protobothropsflavoviridis venom-induced hemorrhage. Pyromellitic acid (1,2,4,5-benzenetetracarboxylic acid) was found to be a potent inhibitor of hemorrhage, with an IC(50) value of 0.035 μM. In addition, most of the antihemorrhagic activity of compounds tested in this experiment showed good correlation to acidity.
authors: Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku, Nagoya 468-8503, Japan.
authors: Hnin Thanda
authors: HT
authors: Aung
authors: Toshiaki
authors: T
authors: Nikai
authors: Masatake
authors: M
authors: Niwa
authors: Yoshiaki
authors: Y
authors: Takaya
mesh_terms: D000818:Animals; D000997:Antivenins / Q000737:chemistry* / Q000494:pharmacology*; D001565:Benzoates / Q000737:chemistry* / Q000494:pharmacology*; D003435:Crotalid Venoms / Q000037:antagonists & inhibitors*; D006470:Hemorrhage / Q000139:chemically induced / Q000188:drug therapy*; D006801:Humans; D013329:Structure-Activity Relationship
chemical_list: D000997:Antivenins; D001565:Benzoates; D003435:Crotalid Venoms