title: Huprine derivatives as sub-nanomolar human acetylcholinesterase inhibitors: from rational design to validation by X-ray crystallography.
authors: Equipe de Chimie Bio-organique, COBRA-CNRS UMR 6014 & FR 3038, Rue Lucien Tesnière, 76131 Mont-Saint-Aignan, France.
authors: Cyril
authors: C
authors: Ronco
authors: Eugénie
authors: E
authors: Carletti
authors: Jacques-Philippe
authors: JP
authors: Colletier
authors: Martin
authors: M
authors: Weik
authors: Florian
authors: F
authors: Nachon
authors: Ludovic
authors: L
authors: Jean
authors: Pierre-Yves
authors: PY
authors: Renard
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000544:Alzheimer Disease / Q000188:drug therapy / Q000201:enzymology; D000634:Aminoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004285:Dogs; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D008958:Models, Molecular; D012996:Solutions; D013237:Stereoisomerism; D013816:Thermodynamics
chemical_list: D000634:Aminoquinolines; D002800:Cholinesterase Inhibitors; D006576:Heterocyclic Compounds, 4 or More Rings; D012996:Solutions; C404518:huprine X; C404519:huprine Y; D000110:Acetylcholinesterase