title: 3,4'-Linked bis(piperidines) related to the haliclonacyclamine class of marine alkaloids: synthesis using crossed-aldol chemistry and preliminary biological evaluations.
abstract: Compounds 2-5, incorporating various elements of the 3,4'-bis(piperidine) core associated with the sponge-derived alkaloid haliclonacyclamine A (HA, 1), have been prepared through, inter alia, aldol-type reactions of N-substituted piperidin-4-ones and certain derivatives. Screening of these compounds in various assays, including an ecological one, reveals that compound 5 exhibits allelochemical properties similar to those associated with HA itself.
authors: Research School of Chemistry, Institute of Advanced Studies, The Australian National University, Canberra, ACT 0200, Australia. mgb@rsc.anu.edu.au
authors: Martin G
authors: MG
authors: Banwell
authors: Mark J
authors: MJ
authors: Coster
authors: Natasha L
authors: NL
authors: Hungerford
authors: Mary J
authors: MJ
authors: Garson
authors: Stephen
authors: S
authors: Su
authors: Andrew C
authors: AC
authors: Kotze
authors: Murray H G
authors: MH
authors: Munro
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011161:Porifera / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D010880:Piperidines