title: Asthma-related SNP in FCER2 is associated with increased expression of IL-4R on human B cells.
abstract: A SNP (rs2228137) (R62W) in FCER2 has been linked with severe exacerbations in asthmatics. Transfectants expressing the SNP exhibited increased IL-4Rα expression after stimulation through CD23 compared with wild-type. Our data suggest that the SNP may favour increased IgE production through increased responsiveness to IL-4 in patients possessing this genotype.
authors: Department of Pediatric Immunology, Children's Mercy Hospital, Kansas City, MO, USA. machan@cmh.edu
authors: M A
authors: MA
authors: Chan
authors: N M
authors: NM
authors: Gigliotti
authors: J
authors: J
authors: Meng
authors: L J
authors: LJ
authors: Rosenwasser
mesh_terms: D001249:Asthma / Q000235:genetics* / Q000276:immunology*; D001402:B-Lymphocytes / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D006801:Humans; D053662:Interleukin-4 Receptor alpha Subunit / Q000235:genetics* / Q000378:metabolism; D037181:Lectins, C-Type / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017455:Receptors, IgE / Q000235:genetics* / Q000378:metabolism; D014162:Transfection; D020298:U937 Cells
chemical_list: C546930:FCER2 protein, human; C504000:IL4R protein, human; D053662:Interleukin-4 Receptor alpha Subunit; D037181:Lectins, C-Type; D017455:Receptors, IgE