title: Flux of selected body fluid constituents and benzylpenicillin in polyacrylamide hydrogel (PAAG).
abstract: The polyacrylamide hydrogel (PAAG) Aquamid® (Contura International A/S Soeborg, Denmark) is one of the new macromolecules that are used as implants and tissue fillers in reconstruction and aesthetic surgery. This study showed, by means of radioactive isotope methods, that PAAG can exchange both physiological and non-physiological constituents very efficiently with the surrounding medium. The efflux (J, mole/(cm(2)× s), 25 °C, pH 7.2) of water (4.4 × 10(-5) ), chloride (2.4 × 10(-7) ), urea (1.0 × 10(-9) ), and glucose (1.1 × 10(-9) ) was 3-40x greater than in human red blood cells. PAAG was also accessible to sucrose, inulin, and benzylpenicillin that could not permeate biological cell membranes. The conclusion of the study is that the hydrogel structure created no significant barrier to the exchange of solvent and solutes with the surrounding medium.
authors: Department of Cellular and Molecular Medicine, University of Copenhagen, DK-2200, Copenhagen, N, Denmark. jbrahm@sund.ku.dk
authors: J
authors: J
authors: Brahm
authors: R
authors: R
authors: Lessel
authors: S
authors: S
authors: Ditlev
authors: R
authors: R
authors: Schmidt
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000493:pharmacokinetics*; D001692:Biological Transport; D001826:Body Fluids / Q000378:metabolism; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D008297:Male; D008954:Models, Biological; D010400:Penicillin G / Q000737:chemistry / Q000493:pharmacokinetics*; D019736:Prostheses and Implants; D019651:Plastic Surgery Procedures
chemical_list: D000180:Acrylic Resins; D000900:Anti-Bacterial Agents; C486838:Aquamid; D020100:Hydrogels; D010400:Penicillin G