title: Efficient generation of ortho-quinone methide: application to the biomimetic syntheses of (±)-schefflone and tocopherol trimers.
abstract: An efficient method using silver oxide-mediated oxidation for the synthesis of ortho-quinone methides has been developed and applied to the biomimetic syntheses of novel trimeric natural products, (±)-schefflone and tocopherol trimers. Further studies of the critical trimerization as well as substrate scope and limitations are also reported.
authors: School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China.
authors: Daohong
authors: D
authors: Liao
authors: Houhua
authors: H
authors: Li
authors: Xiaoguang
authors: X
authors: Lei
mesh_terms: D040761:Biomimetic Materials / Q000138:chemical synthesis*; D045563:Indolequinones / Q000737:chemistry*; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry*; D010084:Oxidation-Reduction; D024505:Tocopherols / Q000737:chemistry*
chemical_list: D045563:Indolequinones; D039821:Monoterpenes; C483218:schefflone; C068040:quinone methide; D024505:Tocopherols