title: Long non-coding RNAs in nuclear bodies.
abstract: High-throughput analyses of mammalian transcriptomes have revealed that more than half of the transcripts produced by RNA polymerase II are non-protein-coding. One class of these non-coding transcripts is the long non-coding RNAs (lncRNAs), which are more than 200 nucleotides in length and are molecularly indistinguishable from other protein-coding mRNAs. Although the molecular functions of these lncRNAs have long remained unknown, emerging evidence implicates the functional involvement of lncRNAs in the regulation of gene expression through the modification of chromatin, maintenance of subnuclear structures, transport of specific mRNAs, and control of pre-mRNA splicing. Here, we discuss the functions of a distinct group of vertebrate-specific lncRNAs, NEAT1/MENε/β/VINC, MALAT1/NEAT2, and Gomafu/RNCR2/MIAT, which accumulate abundantly within the nucleus as RNA components of specific nuclear bodies.
authors: RNA Biology Laboratory, RIKEN Advanced Research Institute, Wako, Saitama, Japan.
authors: Joanna Y
authors: JY
authors: Ip
authors: Shinichi
authors: S
authors: Nakagawa
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D051379:Mice; D018345:Mice, Knockout; D010641:Phenotype; D017393:RNA Editing; D012322:RNA Precursors / Q000235:genetics*; D012326:RNA Splicing; D062085:RNA, Long Noncoding / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D002843:Chromatin; C557040:Malat1 long non-coding RNA, mouse; C517383:Miat long non-coding RNA; C577275:NEAT1 long non-coding RNA, mouse; D012322:RNA Precursors; D062085:RNA, Long Noncoding; D012333:RNA, Messenger