title: Dynamic changes in the inner ear function and vestibular neural pathway related to the progression of labyrinthine infarction in patient with an anterior inferior cerebellar artery infarction.
abstract: OBJECTIVE
  To describe changes in the inner ear function and the vestibular neural pathway according to the progression of a labyrinthine infarction in a patient with an anterior inferior cerebellar artery (AICA) infarction.
  
  
  METHODS
  A 58-year-old woman with hypertension who presented with isolated inner ear symptoms similar to those of endolymphatic hydrops but finally progressed to an AICA infarction.
  
  
  METHODS
  Serial neurotologic testing according to progression to an AICA infarction and antiplatelet therapy.
  
  
  METHODS
  Radiologic findings and neurotologic parameters, including pure tone audiogram thresholds, spontaneous nystagmus, summating potentials/action potentials on electrocochleography, interaural amplitude difference on the vestibular-evoked myogenic potential test, canal paresis and fixation index on the bithermal caloric test, and gain on oculomotor tests.
  
  
  RESULTS
  Our patient initially presented with sudden hearing loss and was diagnosed with an acute AICA infarction on a follow up MRI. Dynamic change in neurotologic testing was observed during disease progression. The vertigo and motion intolerance improved gradually after antiplatelet therapy.
  
  
  CONCLUSIONS
  Changes in the clinical profile, which were documented during a transition from isolated labyrinthine ischemia to an AICA infarction, suggest that sensitivity to an ischemic injury is variable in different components of the labyrinthine organs in addition to providing a new insight into the response of vestibular neural pathway to ischemic injury.
authors: Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University Sacred Heart Hospital, Gyeonggi-do, Republic of Korea.
authors: Duk Rim
authors: DR
authors: Kim
authors: Hyo-Jeong
authors: HJ
authors: Lee
authors: Hyung-Jong
authors: HJ
authors: Kim
authors: Sung Kwang
authors: SK
authors: Hong
mesh_terms: D001158:Arteries / Q000503:physiopathology; D020520:Brain Infarction / Q000150:complications / Q000503:physiopathology*; D002150:Caloric Tests; D002531:Cerebellum / Q000098:blood supply* / Q000503:physiopathology*; D018450:Disease Progression; D007758:Ear, Inner / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D014717:Vertigo / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*