title: Towards biologically active self-assemblies: model nucleotide chimeras.
abstract: With this article, we wish to give an overview of our main research activities assessing the potential of a suitable polymer modification of DNA fragments to self-assemble biologically active nanostructures. Specifically, the grafting of a hydrophobic polymer segment on DNA fragments  results in amphiphilic nucleotide-based macromolecules, which, owing to both chemical and physical incompatibility, organize in self-assembled structures either on surfaces or in aqueous solution. Through the combination of the existing know-how in polymer chemistry with modern analytical  techniques, we are currently focusing on establishing the mechanism of self-assembly of the polymer-modified nucleotide sequences in solution and on surfaces prior to the assessment of their hybridization capacity once involved in the ensemble. With the evaluation of the potential of the functional  nanostructures to undergo biological-like adhesion through hybridization one can eventually foresee that the optimal functionality of these bio-inspired systems could be fine-tuned for biological applications such as drug delivery, gene therapy, tissue engineering and the design of either  biomedical devices or biosensors.
authors: Département de chimie minérale, analytique et appliquée, Université de Genève - Sciences II, 30, quai Ernest-Ansermet, CH-1211 Genève 4, Switzerland. corinne.vebert@unige.ch
authors: Corinne
authors: C
authors: Vebert-Nardin
mesh_terms: D000268:Adhesiveness; D001483:Base Sequence; D001671:Biochemistry / Q000379:methods*; D001672:Biocompatible Materials / Q000737:chemistry*; D015374:Biosensing Techniques; D004247:DNA / Q000737:chemistry; D016503:Drug Delivery Systems; D018625:Microscopy, Atomic Force / Q000379:methods; D008855:Microscopy, Electron, Scanning; D008956:Models, Chemical; D008969:Molecular Sequence Data; D049329:Nanostructures / Q000737:chemistry; D009711:Nucleotides / Q000737:chemistry*; D011090:Polyenes / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D013053:Spectrophotometry / Q000379:methods; D014466:Ultraviolet Rays
chemical_list: D001672:Biocompatible Materials; D009711:Nucleotides; D011090:Polyenes; D011108:Polymers; C008967:polyisobutylene; D004247:DNA