title: [Clinical factors predicting for neoplastic transformation of gastric hyperplastic polyps].
abstract: OBJECTIVE
  Hyperplastic polyps (HPs) are the most common cause of all benign epithelial gastric polyps, constituting 30 to 93%. Although gastric HPs are usually considered as benign lesions compared with adenoma, neoplastic transformation has been known to occur rarely. We aimed to identify the clinical factors of gastric HPs predicting for neoplastic transformation.
  
  
  METHODS
  Between January 2002 to August 2010, a total of 274 gastric HPs, which had been removed by endoscopic polypectomy or surgical resection from 210 patients, were analyzed retrospectively.
  
  
  RESULTS
  Neoplastic transformation was found in 15 cases (5.5%) of 274 HPs including 10 cases of low grade dysplasia (3.7%), 2 cases of high grade dysplasia (0.7%) and 3 cases of adenocarcinoma (1.1%). Neoplastic transformations were significantly associated with >1 cm in size (n=10 [66.7%] vs. n=91 [35.1%], p=0.024), with pedunculated shape (n=9 [60.0%] vs. n=62 [23.9%], p=0.002), with previous history of gastrectomy (n=3 [20.0%] vs. n=3 [1.2%], p=0.002) and with synchronous neoplastic lesions occurring elsewhere in the gastric mucosa (n=5 [33.3%] vs. n=31 [12.0%], p=0.021). However, no significant difference was found between HPs with and without neoplastic transformation in terms of age, sex, number of polyps detected per patient, location, macroscopic appearance such as erosion, hyperemia.
  
  
  CONCLUSIONS
  Neoplastic transformation of gastric HPs had significant relationships with 1 cm in size, pedunculated shape, postgastectomy state, and synchronous neoplastic lesion. Therefore, endoscopic polypectomy should be considered in these HPs to avoid the risk of missing HPs with neoplastic potential.
authors: Departments of Internal Medicine and Pathology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
authors: Hwa Mi
authors: HM
authors: Kang
authors: Tae Hoon
authors: TH
authors: Oh
authors: Ji Young
authors: JY
authors: Seo
authors: Tae Joo
authors: TJ
authors: Joen
authors: Dong Dae
authors: DD
authors: Seo
authors: Won Chang
authors: WC
authors: Shin
authors: Won Choong
authors: WC
authors: Choi
authors: Jung Yeon
authors: JY
authors: Kim
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D000367:Age Factors; D000368:Aged; D002471:Cell Transformation, Neoplastic; D005260:Female; D005773:Gastroscopy; D006801:Humans; D006965:Hyperplasia; D008297:Male; D008875:Middle Aged; D011127:Polyps / Q000473:pathology* / Q000601:surgery; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012737:Sex Factors; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery