title: Three large, functioning cystic parathyroid adenomas.
abstract: OBJECTIVE
  To report a very rare case of 3 large, functioning cystic parathyroid adenomas causing primary hyperparathyroidism.
  
  
  METHODS
  We present the history, clinical findings, laboratory test results, radiologic findings, endocrine workup results, intraoperative surgical challenges, and surgical pathology report of the study patient. We review the literature and discuss the importance of intraoperative parathyroid hormone (PTH) measurement in such cases.
  
  
  RESULTS
  A 79-year-old woman presented with primary hyperparathyroidism and elevated levels of calcium and PTH. Localization studies confirmed the presence of a large right upper parathyroid adenoma. On exploration, a very large cystic parathyroid gland was identified at that location. Because intraoperative PTH levels remained elevated, further exploration was pursued, which revealed 2 more large cystic glands on the left side that were resected. This resulted in an adequate but slow PTH drop. The right lower gland appeared normal. On follow-up 4 days and 6 weeks after surgery, the calcium and PTH levels had normalized.
  
  
  CONCLUSIONS
  This case highlights the aspects of intraoperative PTH use and underscores the need to exclude multigland disease even in the setting of a very large parathyroid cyst with concordant localization studies.
authors: Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, Wisconsin 53792, USA.
authors: Haggi
authors: H
authors: Mazeh
authors: Rebecca S
authors: RS
authors: Sippel
authors: Herbert
authors: H
authors: Chen
mesh_terms: D000236:Adenoma / Q000150:complications / Q000473:pathology* / Q000601:surgery; D000368:Aged; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000209:etiology; D010281:Parathyroid Hormone / Q000097:blood; D010282:Parathyroid Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D016105:Parathyroidectomy; D016606:Thyroid Nodule / Q000150:complications / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D010281:Parathyroid Hormone; D002118:Calcium