title: Mean nuclear volume in complex atypical hyperplasia and adenocarcinoma of the endometrium.
abstract: OBJECTIVE
  To explore the possible role of mean nuclear volume (MNV) in differentiating complex atypical hyperplasia (CAH) from well-differentiated adenocarcinoma (WDAC) of the endometrium.
  
  
  METHODS
  In this retrospective study we measured MNV in 15 cases each of CAH and WDAC using the point intercepts method. At least 100 nuclei were selected for MNV estimation in each case.
  
  
  RESULTS
  The mean MNV in CAH was 430.06 microm3 (SD 232.43); the MNV in WDAC was 753.14 microm3 (SD 322.87). Independent sample t test showed significant difference (p < 0.005) of MNV between CAH and WDAC.
  
  
  CONCLUSIONS
  MNV determination resulted in a wide-ranging overlap of distributions for CAH and WDAC cases, such that at best only a modest proportion of cases with very low MNV values offer a diagnostic clue.
authors: Department of Cytology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors: Jasleen
authors: J
authors: Kaur
authors: Pranab
authors: P
authors: Dey
mesh_terms: D000230:Adenocarcinoma; D002467:Cell Nucleus; D004717:Endometrium; D005260:Female; D006801:Humans; D006965:Hyperplasia; D011230:Precancerous Conditions; D012189:Retrospective Studies