title: [Comparison of seasonal influenza vaccines: composition and properties].
abstract: The influenza virus isolation in embryonated chicken eggs was possible early in 1930er years and allowed the influenza vaccine production. Most influenza vaccines were derived from this, but actually new virus cell culture methods are established. For better tolerability, influenza vaccines include only antigen proportions (split- and subunit vaccines) but with the disadvantage of minor vaccine efficacy. This was compared with the addition of adjuvants. Aluminium salts are used for many decades and still in use to enhance the effect of vaccines. New formulations are MF59, AS03, AS04 or toll- like receptor-agonists. Also virosomal formulations and "ISCOMs"(Immune Stimulating Complexes) are newly designed and compromises enhanced immune reactions. Actually a broad range of various influenza vaccines exist and are available for a very different group of patients (which depends on physical conditions, age, immune status or allergies).
authors: Institut für Med. Virologie und Impfambulanz, Frankfurt/Main. allwinn@em.uni-frankfurt.de
authors: R
authors: R
authors: Allwinn
authors: H W
authors: HW
authors: Doerr
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005858:Germany; D006801:Humans; D016882:ISCOMs / Q000009:adverse effects / Q000737:chemistry / Q000276:immunology; D007223:Infant; D009980:Influenza A virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000009:adverse effects / Q000737:chemistry / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control*; D008081:Liposomes; D032541:Mass Vaccination; D008875:Middle Aged; D019444:Vaccines, DNA / Q000009:adverse effects / Q000737:chemistry / Q000276:immunology; D015164:Vaccines, Inactivated / Q000009:adverse effects / Q000737:chemistry / Q000276:immunology; D022223:Vaccines, Subunit / Q000009:adverse effects / Q000737:chemistry / Q000276:immunology; D022721:Vaccines, Virosome / Q000009:adverse effects / Q000737:chemistry / Q000276:immunology; D014776:Virus Cultivation / Q000379:methods; D055815:Young Adult
chemical_list: D000276:Adjuvants, Immunologic; D016882:ISCOMs; D007252:Influenza Vaccines; D008081:Liposomes; D019444:Vaccines, DNA; D015164:Vaccines, Inactivated; D022223:Vaccines, Subunit; D022721:Vaccines, Virosome