title: Toxins-useful biochemical tools for leukocyte research.
abstract: Leukocytes are a heterogeneous group of cells that display differences in anatomic localization, cell surface phenotype, and function. The different subtypes include e.g., granulocytes, monocytes, dendritic cells, T cells, B cells and NK cells. These different cell types represent the cellular component of innate and adaptive immunity. Using certain toxins such as pertussis toxin, cholera toxin or clostridium difficile toxin, the regulatory functions of Gα(i), Gαs and small GTPases of the Rho family in leukocytes have been reported. A summary of these reports is discussed in this review.
authors: Department of Dermatology, Medical School Jena, Erfurter Strasse 35, 07740, Jena, Germany. susana.cubillos@med.uni-jena.de
authors: Susana
authors: S
authors: Cubillos
authors: Johannes
authors: J
authors: Norgauer
authors: Katja
authors: K
authors: Lehmann
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000494:pharmacology; D001427:Bacterial Toxins / Q000494:pharmacology*; D002772:Cholera Toxin / Q000494:pharmacology; D004768:Enterotoxins / Q000494:pharmacology; D019206:GTP-Binding Protein alpha Subunits, Gi-Go / Q000502:physiology; D006801:Humans; D007962:Leukocytes / Q000187:drug effects* / Q000502:physiology; D037342:Pertussis Toxin / Q000494:pharmacology; D043562:Receptors, G-Protein-Coupled / Q000502:physiology
chemical_list: D001426:Bacterial Proteins; D001427:Bacterial Toxins; D004768:Enterotoxins; D043562:Receptors, G-Protein-Coupled; C041348:tcdA protein, Clostridium difficile; C031815:toxB protein, Clostridium difficile; D002772:Cholera Toxin; D037342:Pertussis Toxin; D019206:GTP-Binding Protein alpha Subunits, Gi-Go