title: Preparation and properties of nanoscale containers for biomedical application in drug delivery: preliminary studies with kynurenic acid.
abstract: The main purpose of this study was to facilitate the delivery of kynurenic acid (KYNA) across the blood-brain barrier (BBB) by applying micelles as nanoscale containers. Non-ionic amphiphilic molecules were used for preparation of spherical micelles for delivery of kynurenic acid in aqueous solution in physiological condition. It was established that Triton X 100 and Lutensol AP 20 non-ionic surfactants are able to produce stable nanocontainers for delivery of kynurenic acid molecules. The incorporation of KYNA molecules was investigated by dynamic light scattering and the size of micelles were calculated between 5 and 10 nm in 150 mM NaCl and pH 7.5-7.6 solutions. Encapsulated kynurenic acid showed a significantly higher blood-brain barrier permeability compared with non-encapsulated kynurenic acid. The in vivo experiments showed that the encapsulated kynurenic acid is able to display effects within the central nervous system, even after its peripheral administration.
authors: Supramolecular and Nanostructured Materials Research Group of the Hungarian Academy of Sciences, Faculty of Medicine, Institute of Medical Chemistry, and Nanomedicine Program, University of Szeged, Aradi v.t.1, Szeged, 6720, Hungary.
authors: V
authors: V
authors: Hornok
authors: T
authors: T
authors: Bujdosó
authors: J
authors: J
authors: Toldi
authors: K
authors: K
authors: Nagy
authors: I
authors: I
authors: Demeter
authors: C
authors: C
authors: Fazakas
authors: I
authors: I
authors: Krizbai
authors: L
authors: L
authors: Vécsei
authors: I
authors: I
authors: Dékány
mesh_terms: D000818:Animals; D020811:Biomedical Technology / Q000379:methods*; D018920:Coculture Techniques; D016503:Drug Delivery Systems / Q000379:methods*; D007736:Kynurenic Acid / Q000008:administration & dosage* / Q000737:chemistry; D008823:Micelles; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
chemical_list: D008823:Micelles; D007736:Kynurenic Acid