title: Bimolecular reaction via the successive introduction of two substrates into the crystals of networked molecular cages.
abstract: Two substrates, 4-hydroxydiphenylamine (3) and ethyl isocyanate (4), were successively introduced into the crystals of networked M(6)L(4) cages 1. Because of the encapsulation effect, most of the initially introduced substrate 3 remained within the crystals during immersion in a solution of 4. X-ray analysis revealed that before the reaction, the nucleophilic NH group of 3 is effectively protected by tight packing within the cage units while the OH group is exposed to the incoming second substrate. Successive introduction of 4 into the crystal results in the chemoselective acylation of 3 at the less nucleophilic OH group. The observed chemoselectivity is consistent with that exhibited by discrete M(6)L(4) cage 2 in solution.
authors: Department of Applied Chemistry, School of Engineering, The University of Tokyo, and JST-CREST, 7-3-1 Hongo, Tokyo 113-8656, Japan.
authors: Yasuhide
authors: Y
authors: Inokuma
authors: Nodoka
authors: N
authors: Kojima
authors: Tatsuhiko
authors: T
authors: Arai
authors: Makoto
authors: M
authors: Fujita