title: Preparation, characterization and application of chitosan-alginate based polyelectrolyte complex as fast disintegrating drug delivery carrier.
abstract: OBJECTIVE
  Present investigation was carried out with aim to synthesize chitosan-alginate polyelectrolyte complex, their characterization and then formulation of phenytoin sodium fast dispersible tablet using polyelectrolyte as active excipient.
  
  
  METHODS
  In this study, polyelectrolyte complex was formed by ionic cross-linking of polymers. Dried complex was evaluated for micromeritic properties and flow behaviour. Tablets were prepared for six batches based on different proportion of complex viz 5%, 10%, 20%, 30%, 40%, 50% and 60%. Tablets were evaluated for hardness, friability, thickness, in vitro disintegration time, in vitro dissolution study and stability study.
  
  
  RESULTS
  Results of micromeritic study and flow behaviour predict that complex can be used as an efficient excipient. Hardness, friability, thickness all were in acceptable limit. Release studies were showed that tablets release drug up to 99.97%. Batch showed .sec of invitro disintegration time. Stability study easily predicted that formulation characteristics dose not changed during the whole period of study.
  
  
  CONCLUSIONS
  From the findings it is concluded that chitosan-alginate polyelectrolyte complex is efficient excipient for fast dispersible formulation especially required in case of epilepsy and chronic diseases.
authors: Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Bypass Road, Baghpat Crossing, Meerut-250005, Uttar Pradesh, India. rishabhamalviya19@gmail.com
authors: Rishabha
authors: R
authors: Malviya
authors: Pranati
authors: P
authors: Srivastava
mesh_terms: D000464:Alginates / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D005079:Excipients / Q000737:chemistry*; D011073:Polyamines / Q000737:chemistry*; D000071228:Polyelectrolytes; D013607:Tablets / Q000737:chemistry*
chemical_list: D000464:Alginates; D048271:Chitosan; D004337:Drug Carriers; D005079:Excipients; D011073:Polyamines; D000071228:Polyelectrolytes; D013607:Tablets