title: The deposition of Hg203-chlormerodrin in experimental brain tumors.
abstract: The deposition of Hg203-chlormerodrin was studied in intracranial tumors in mice induced by implantation of 20-methyl cholanthrene by tissue assay, as well as light microscopic and electron microscopic autoradiography. The investigations were carried out in astrocytomas, glioblastomas, and meningeal tumors. The chlormerodrin content of the tumors exceeded that of normal brain with a significant tumor/brain ratio ranging from 5.8 to 22.5. It was found that the chlormerodrin molecule becomes rapidly incorporated in the tumor cells, with a preference for that portion of the cytoplasm associated with the vacuolar system.
authors: Division of Neurosurgery, State University of New York at Buffalo Medical School, Buffalo, New York 14203, USA.
authors: T
authors: T
authors: Kobayashi
authors: L
authors: L
authors: Bakay
authors: J C
authors: JC
authors: Lee
mesh_terms: D000818:Animals; D001345:Autoradiography / Q000379:methods; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D002717:Chlormerodrin / Q000493:pharmacokinetics; D004195:Disease Models, Animal; D005909:Glioblastoma / Q000000981:diagnostic imaging*; D008631:Mercury Radioisotopes / Q000493:pharmacokinetics; D051379:Mice; D008809:Mice, Inbred C3H; D008854:Microscopy, Electron; D011877:Radionuclide Imaging; D014018:Tissue Distribution
chemical_list: D008631:Mercury Radioisotopes; D002717:Chlormerodrin