title: Myocardial therapeutic angiogenesis: a review of the state of development and future obstacles.
abstract: A significant percentage of patients have coronary artery disease that is too advanced or diffuse for percutaneous or surgical intervention. Therapeutic angiogenesis is a treatment modality to induce vessel formation that is being developed for patients with advanced coronary disease not amenable to currently available interventions. A number of approaches to induce coronary collateralization are being developed. These include gene, protein, cellular and miRNA modalities, each of which have advantages and disadvantages. At this time, no modality has emerged as the single clear choice, and combination therapies may provide synergistic benefits. However, there have been a number of recent studies advancing our knowledge as to how we can refine procollateralizing treatments. In this article, we will examine some recent successes and future obstacles in the effort to bring therapeutic angiogenesis to patients.
authors: Department of Surgery, Division of Cardiothoracic Surgery, Warren Alpert School of Medicine, Brown University, Providence, RI 02905, USA.
authors: Michael P
authors: MP
authors: Robich
authors: Louis M
authors: LM
authors: Chu
authors: Shizu
authors: S
authors: Oyamada
authors: Neel R
authors: NR
authors: Sodha
authors: Frank W
authors: FW
authors: Sellke
mesh_terms: D000818:Animals; D003324:Coronary Artery Disease / Q000473:pathology / Q000628:therapy*; D006801:Humans; D009204:Myocardial Revascularization / Q000379:methods*; D009206:Myocardium / Q000378:metabolism; D018919:Neovascularization, Physiologic