title: Excess dietary iodine differentially affects thyroid gene expression in diabetes, thyroiditis-prone versus -resistant BioBreeding (BB) rats.
abstract: METHODS
  To identify genes involved in the susceptibility to iodine-induced autoimmune thyroiditis.
  
  
  RESULTS
  Diabetes, thyroiditis-prone (BBdp) and -resistant (BBc) rats were fed either a control or a high-iodine diet for 9 wk. Excess iodine intake increased the incidence of insulitis and thyroiditis in BBdp rats. BBdp rats fed the high-iodine diet that did not develop thyroiditis had higher mRNA levels of Fabp4, Cidec, perilipin, Pparγ and Slc36a2 than BBdp rats fed the control diet and BBc rats fed either the control or the high-iodine diet. BBdp rats fed the high-iodine diet that did develop thyroiditis had higher mRNA levels of Cidec, Icam1, Ifitm1, and Slpi than BBdp rats fed the control diet and BBc rats fed either the control or the high-iodine diet. BBdp rats that did develop thyroiditis had lower mRNA levels of Fabp4, perilipin and Slc36a2 but higher mRNA levels of Icam1, Ifitm1 and Slpi than BBdp that did not develop thyroiditis. Excess dietary iodine also increased the protein levels of Fabp4, Cidec and perilipin in BBdp rats.
  
  
  CONCLUSIONS
  Differential expression of thyroid genes in BBdp versus BBc rats caused by excess dietary iodine may be implicated in autoimmune thyroiditis and insulitis pathogenesis.
authors: Nutrition Research Division, Food Directorate, Health Products and Food Branch, Health Canada, Banting Research Centre, Ottawa, Ontario, Canada.
authors: Eleonora
authors: E
authors: Swist
authors: QiXuan
authors: Q
authors: Chen
authors: Cunye
authors: C
authors: Qiao
authors: Don
authors: D
authors: Caldwell
authors: Heidi
authors: H
authors: Gruber
authors: Kylie A
authors: KA
authors: Scoggan
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D003920:Diabetes Mellitus / Q000378:metabolism / Q000473:pathology; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism / Q000473:pathology; D004032:Diet; D050556:Fatty Acid-Binding Proteins / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D005260:Female; D007455:Iodine / Q000008:administration & dosage* / Q000009:adverse effects*; D009748:Nutrition Disorders / Q000473:pathology; D000070778:Perilipin-1; D010750:Phosphoproteins / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D051381:Rats; D011913:Rats, Inbred BB; D013961:Thyroid Gland / Q000378:metabolism* / Q000473:pathology; D013963:Thyroid Hormones / Q000097:blood; D013967:Thyroiditis, Autoimmune / Q000139:chemically induced / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D015854:Up-Regulation
chemical_list: D002352:Carrier Proteins; C524662:FABP4 protein, rat; D050556:Fatty Acid-Binding Proteins; D000070778:Perilipin-1; D010750:Phosphoproteins; D012333:RNA, Messenger; D013963:Thyroid Hormones; D007455:Iodine