title: Vascular endothelial growth factor polymorphisms are involved in the late vascular complications in Type II diabetic patients.
abstract: OBJECTIVE
  To determine the potential genotype differences in the vascular endothelial growth factor (VEGF) gene in diabetic patients, which might explain the difference in terms of the development of clinical vascular complications: great vessels atherosclerosis vs. retinopathy.
  
  
  METHODS
  Genotyping of the VEFG gene insertion/deletion -2549, the C-2578A and the G+405C polymorphisms was done in 40 diabetic patients (26 with peripheral artery disease (PAD) and 14 with diabetic retinopathy (DR)).
  
  
  RESULTS
  There was a significant increase in the frequency of the VEGF -2549 DD genotype in PAD patients compared with the DR group (34.6 vs. 0; p = 0.016), as well as in the distribution of the VEGF -2549 ID genotype in DR compared with PAD patients (85.7 vs. 38.4; p = 0.005). There was a significant increase in the frequency of the VEGF -2578 CC genotype in the PAD group compared with DR (34.6 vs. 0; p = 0.016), as well as in the VEGF -2578 CA genotype in DR patients compared with PAD (85.7 vs. 34.6; p = 0.002). The VEGF +405 genotype was not associated with diabetic vascular complications.
  
  
  CONCLUSIONS
  This study provides preliminary evidence that VEGF polymorphisms are associated with a differential presentation of diabetic vascular complications.
authors: Vascular Surgery and Angiology Department, Hospital Universitario Getafe, Carretera de Toledo Km 12.5, 28905 Madrid, Spain. silbleik@yahoo.es
authors: Silvia
authors: S
authors: Bleda
authors: Joaquin
authors: J
authors: De Haro
authors: Cesar
authors: C
authors: Varela
authors: Leticia
authors: L
authors: Esparza
authors: Antonio
authors: A
authors: Ferruelo
authors: Francisco
authors: F
authors: Acin
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000235:genetics*; D003930:Diabetic Retinopathy / Q000097:blood / Q000209:etiology / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016254:Mutagenesis, Insertional; D016017:Odds Ratio; D058729:Peripheral Arterial Disease / Q000097:blood / Q000209:etiology / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D012307:Risk Factors; D013030:Spain; D042461:Vascular Endothelial Growth Factor A / Q000097:blood / Q000235:genetics*
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A