title: Kidins220/ARMS is an essential modulator of cardiovascular and nervous system development.
abstract: The growth factor family of neurotrophins has major roles both inside and outside the nervous system. Here, we report a detailed histological analysis of key phenotypes generated by the ablation of the Kinase D interacting substrate of 220 kDa/Ankyrin repeat-rich membrane spanning (Kidins220/ARMS) protein, a membrane-anchored scaffold for the neurotrophin receptors Trk and p75(NTR). Kidins220 is important for heart development, as shown by the severe defects in the outflow tract and ventricle wall formation displayed by the Kidins220 mutant mice. Kidins220 is also important for peripheral nervous system development, as the loss of Kidins220 in vivo caused extensive apoptosis of DRGs and other sensory ganglia. Moreover, the neuronal-specific deletion of this protein leads to early postnatal death, showing that Kidins220 also has a critical function in the postnatal brain.
authors: Department of Neuroscience and Brain Technologies, The Italian Institute of Technology, Genoa, Italy. fabrizia.cesca@iit.it
authors: F
authors: F
authors: Cesca
authors: A
authors: A
authors: Yabe
authors: B
authors: B
authors: Spencer-Dene
authors: A
authors: A
authors: Arrigoni
authors: M
authors: M
authors: Al-Qatari
authors: D
authors: D
authors: Henderson
authors: H
authors: H
authors: Phillips
authors: M
authors: M
authors: Koltzenburg
authors: F
authors: F
authors: Benfenati
authors: G
authors: G
authors: Schiavo
mesh_terms: D000818:Animals; D002319:Cardiovascular System / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism*; D016923:Cell Death / Q000502:physiology; D002490:Central Nervous System / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism*; D007150:Immunohistochemistry; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic
chemical_list: C544017:Kidins220 protein, mouse; D008565:Membrane Proteins