title: A pilot study to evaluate 3'-deoxy-3'-18F-fluorothymidine pet for initial and early response imaging in mantle cell lymphoma.
abstract: Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma. Proliferation activity is considered an important prognostic marker. Immunohistochemical analysis from core biopsy or lymph node may not represent the proliferation rate. We investigated the in vivo proliferation marker 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) to characterize MCL.
  
  
  METHODS
  Eight untreated MCL patients were recruited prospectively. (18)F-FLT PET/CT was performed 45 min after injection of (18)F-FLT. (18)F-FDG PET/CT served as reference. Mean (18)F-FLT standardized uptake values were assessed per lesion and compared with respective (18)F-FDG uptake. Correlation of mean (18)F-FLT and (18)F-FDG uptake in the hottest lesion to Ki67 immunostaining was performed. Five patients underwent repetitive early (18)F-FLT PET.
  
  
  RESULTS
  All lymphoma lesions identified by (18)F-FDG PET/CT showed increased (18)F-FLT uptake. Semiquantitative analysis revealed a high mean (18)F-FLT standardized uptake value of 9.9 (range, 5.5-15.9). Mean (18)F-FLT uptake and Ki67 expressions showed a strong positive correlation.
  
  
  CONCLUSIONS
  PET using (18)F-FLT as a biomarker for proliferative activity showed a high sensitivity for MCL. (18)F-FLT uptake shows a correlation with proliferation. Our results warrant further analysis of (18)F-FLT PET in MCL.
authors: Department of Nuclear Medicine, Technische Universität München, Munich, Germany.
authors: Ken
authors: K
authors: Herrmann
authors: Andreas K
authors: AK
authors: Buck
authors: Tibor
authors: T
authors: Schuster
authors: Martina
authors: M
authors: Rudelius
authors: Hans-Jürgen
authors: HJ
authors: Wester
authors: Nicolas
authors: N
authors: Graf
authors: Christine
authors: C
authors: Scheuerer
authors: Christian
authors: C
authors: Peschel
authors: Markus
authors: M
authors: Schwaiger
authors: Tobias
authors: T
authors: Dechow
authors: Ulrich
authors: U
authors: Keller
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001692:Biological Transport; D015224:Dideoxynucleosides / Q000378:metabolism; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D020522:Lymphoma, Mantle-Cell / Q000000981:diagnostic imaging* / Q000235:genetics / Q000378:metabolism / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D049268:Positron-Emission Tomography; D011379:Prognosis; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015224:Dideoxynucleosides; D019394:Ki-67 Antigen; D019788:Fluorodeoxyglucose F18; C002854:alovudine