title: Electrochemical control of growth factor presentation to steer neural stem cell differentiation.
abstract: Let it grow: The conjugated polymer poly(3,4-ethylenedioxythiophene) (PEDOT) was synthesized with heparin as the counterion to form a cell culture substrate. The surface of PEDOT:heparin in the neutral state associated biologically active growth factors. Electrochemical in situ oxidation of PEDOT during live cell culture decreased the bioavailability of the growth factor and created an exact onset of neural stem cell differentiation.
authors: Cell and Molecular Biology, Karolinska Institute von Eulers väg 3, 17177 Solna, Sweden. anna.herland@ki.se
authors: Anna
authors: A
authors: Herland
authors: Kristin M
authors: KM
authors: Persson
authors: Vanessa
authors: V
authors: Lundin
authors: Mats
authors: M
authors: Fahlman
authors: Magnus
authors: M
authors: Berggren
authors: Edwin W H
authors: EW
authors: Jager
authors: Ana I
authors: AI
authors: Teixeira
mesh_terms: D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry; D002454:Cell Differentiation; D049109:Cell Proliferation; D004563:Electrochemistry; D053595:Embryonic Stem Cells / Q000166:cytology* / Q000378:metabolism; D016222:Fibroblast Growth Factor 2 / Q000737:chemistry* / Q000378:metabolism; D006493:Heparin / Q000737:chemistry; D011108:Polymers / Q000737:chemistry
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D011108:Polymers; C121383:poly(3,4-ethylene dioxythiophene); D016222:Fibroblast Growth Factor 2; D006493:Heparin