title: Metabolic and cardiac autonomic effects of high-intensity resistance training protocol in Wistar rats.
abstract: The aim of this study was to assess the effects of metabolic and autonomic nervous control on high-intensity resistance training (HRT) as determined by pancreatic glucose sensitivity (GS), insulin sensitivity (IS), blood lactate ([La]), and heart rate variability (HRV) in rats. Thirty male, albino Wistar rats (292 ± 20 g) were divided into 3 groups: sedentary control (SC), low-resistance training (LRT), and HRT. The animals in the HRT group were submitted to a high-resistance protocol with a progressively increasing load relative to body weight until exhaustion, whereas the LRT group performed the same exercise regimen with no load progression. The program was conducted 3 times per week for 8 weeks. The [La], parameters related to the functionality of pancreatic tissue, and HRV were measured. There was a significant increase in peak [La] only in the HRT group, but there was a reduction in [La] when corrected to the maximal load in both trained groups (LRT and HRT, p < 0.05). Both trained groups exhibited an increase in IS; however, compared with SC and LRT, HRT demonstrated a significantly higher GS posttraining (p < 0.05). With respect to HRV, the low-frequency (LF) band, in milliseconds squared, reduced in both trained groups, but the high-frequency band, in milliseconds squared and nu, increased, and the LF in nu, decreased only in the HRT group (p < 0.05). The HRT protocol produced significant and beneficial metabolic and cardiac autonomic adaptations. These results provide evidence for the positive benefits of HRT in counteracting metabolic and cardiovascular dysfunction.
authors: Cardiopulmonary Physiotherapy Laboratory, Physiotherapy Department, Federal University of Sao Carlos, São Carlos, Brazil.
authors: Ana Paula
authors: AP
authors: de Deus
authors: Claudio Ricardo
authors: CR
authors: de Oliveira
authors: Rodrigo Polaquini
authors: RP
authors: Simões
authors: Vilmar
authors: V
authors: Baldissera
authors: Carlos Alberto
authors: CA
authors: da Silva
authors: Bruno Rafael Orsini
authors: BR
authors: Rossi
authors: Hugo Celso Dutra
authors: HC
authors: de Sousa
authors: Nivaldo Antonio
authors: NA
authors: Parizotto
authors: Ross
authors: R
authors: Arena
authors: Audrey
authors: A
authors: Borghi-Silva
mesh_terms: D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology*; D005951:Glucose Tolerance Test; D006321:Heart / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology; D007333:Insulin Resistance / Q000502:physiology; D007773:Lactates / Q000097:blood; D008297:Male; D010805:Physical Conditioning, Animal / Q000502:physiology*; D005082:Physical Exertion / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar / Q000502:physiology
chemical_list: D007773:Lactates