title: A comparative analysis of viral peptides presented by contemporary human and chimpanzee MHC class I molecules.
abstract: Genetic factors such as the MHC influence the immunocompetence of an individual. MHC genes are the most polymorphic genes in primates, which is often interpreted as an adaptation to establish good T cell responses to a wide range of (evolving) pathogens. Chimpanzee MHC (Patr) genes are less polymorphic than human MHC (HLA) genes, which is surprising because chimpanzee is the older species of the two and is therefore expected to display more variation. To quantify the effect of the reduced polymorphism, we compared the peptide binding repertoire of human and chimpanzee MHC molecules. Using a peptide-MHC binding predictor and proteomes of >900 mammalian viruses, we show that, at the population level, the total peptide binding repertoire of Patr-A molecules is ~36% lower than that of their human counterparts, whereas the reduction of the peptide binding repertoire of the Patr-B locus is only 15%. In line with these results, different Patr-A molecules turn out to have largely overlapping peptide binding repertoires, whereas the Patr-B molecules are more distinct from each other. This difference is somewhat less apparent at the individual level, where we found that only 25% of the viruses are significantly better presented by "simulated" humans with heterozygous HLA-A and -B loci. Taken together, our results indicate that the Patr-B molecules recovered more after the selective sweep, whereas the Patr-A locus shows the most signs of the selective sweep with regard to its peptide binding repertoire.
authors: Theoretical Biology and Bioinformatics, Utrecht University, 3584 CH Utrecht, The Netherlands. H.W.M.vanDeutekom@uu.nl
authors: Hanneke W M
authors: HW
authors: van Deutekom
authors: Ilka
authors: I
authors: Hoof
authors: Ronald E
authors: RE
authors: Bontrop
authors: Can
authors: C
authors: Keşmir
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017951:Antigen Presentation / Q000235:genetics* / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology*; D001483:Base Sequence; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000276:immunology; D015186:Hominidae / Q000235:genetics; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics*; D008969:Molecular Sequence Data; D002679:Pan troglodytes / Q000235:genetics* / Q000276:immunology; D010455:Peptides / Q000276:immunology; D010802:Phylogeny; D011110:Polymorphism, Genetic; D012641:Selection, Genetic
chemical_list: D000956:Antigens, Viral; D015395:Histocompatibility Antigens Class I; D010455:Peptides