title: Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo.
abstract: Mesenchymal stem cells (MSCs) can promote tumor growth in a mouse xenograft model, but the exact mechanism remains unclear. In this study, we investigated the effects of bone marrow MSC-derived exosomes (MSC-exosomes) on tumor growth in vitro and in vivo. Our results showed that MSC-exosomes promoted tumor growth in vivo. MSC-exosomes enhanced vascular endothelial growth factor (VEGF) expression in tumor cells by activating extracellular signal-regulated kinase1/2 (ERK1/2) pathway. Inhibition of ERK1/2 activation reserved the increase of VEGF level by MSC-exosomes. Our findings demonstrate a new mechanism through which MSC-exosome-mediated cell-cell interactions may contribute to tumor progression.
authors: School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, China.
authors: Wei
authors: W
authors: Zhu
authors: Ling
authors: L
authors: Huang
authors: Yahong
authors: Y
authors: Li
authors: Xu
authors: X
authors: Zhang
authors: Jianmei
authors: J
authors: Gu
authors: Yongmin
authors: Y
authors: Yan
authors: Xiaomeng
authors: X
authors: Xu
authors: Mei
authors: M
authors: Wang
authors: Hui
authors: H
authors: Qian
authors: Wenrong
authors: W
authors: Xu
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology* / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology; D048708:Cell Growth Processes / Q000502:physiology; D055354:Exosomes / Q000502:physiology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009369:Neoplasms / Q000473:pathology*; D023041:Xenograft Model Antitumor Assays