title: Polar compounds isolated from the leaves of Albertisia delagoensis (Menispermaceae).
abstract: Aqueous infusions of the leaves of the shrub Albertisia delagoensis (Menispermaceae) are used in South Africa in traditional Zulu medicine to alleviate a variety of symptoms, including fever, and intestinal problems. We report the analysis of such an aqueous extract using the HPLC-NMR technique. A number of polar compounds were identified, including proto-quercitol, nicotinic acid, allantoic acid, 3,4-dihydroxy-benzoic acid, phthalic acid and the aporphine alkaloid derivative roemrefidine. Allantoic acid and roemrefidine have been fully characterised by (1)H- and (13)C-NMR and mass spectrometry. Earlier reports of antiplasmodial activity of roemrefidine and of A. delagoensis extracts are correlated with this study and with the antipyretic properties of neutral aqueous extracts.
authors: School of Biological and Chemical Sciences, Queen Mary University of London, London E1 4NS, UK.
authors: Geoffrey E
authors: GE
authors: Hawkes
authors: Helene
authors: H
authors: de Wet
authors: Jia
authors: J
authors: Li
mesh_terms: D001060:Aporphines / Q000737:chemistry; D001565:Benzoates / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005520:Food Preservatives / Q000737:chemistry; D006801:Humans; D007294:Inositol / Q000031:analogs & derivatives / Q000737:chemistry; D008519:Medicine, Traditional; D029583:Menispermaceae / Q000033:anatomy & histology* / Q000737:chemistry*; D015394:Molecular Structure; D009525:Niacin / Q000737:chemistry; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods; D010795:Phthalic Acids / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification; D018515:Plant Leaves / Q000737:chemistry*; D013019:South Africa; D014508:Urea / Q000031:analogs & derivatives / Q000737:chemistry; D014665:Vasodilator Agents / Q000737:chemistry
chemical_list: D001060:Aporphines; D001565:Benzoates; D005520:Food Preservatives; D010795:Phthalic Acids; D010936:Plant Extracts; D014665:Vasodilator Agents; C483225:proto-quercitol; C120644:roemrefidine; C024081:allantoic acid; D009525:Niacin; D007294:Inositol; C032279:phthalic acid; D014508:Urea