title: Design of a magnesium-pridinolum complex for polylactide-drug conjugates formation.
abstract: Polylactide conjugates of the muscle contraction agent Pridinolum (PriOH = 1,1-diphenyl-3-(1-piperidinyl)-1-propanol) were prepared directly by ring-opening polymerization of L-lactide (L-LA) mediated by the pridinolum magnesium complex [Mg(μ,η(2)-OPri)(η(1)-OPri)](2). The ancillary O,N - bifunctional drug as a ligand stabilizes the magnesium species and initiates L-LA polymerization affording a polymer chain terminated by covalently attached drug molecules to the PLLA through ester linkers to form PriO-PLLA conjugate. Up to 80% of the pridinolum can be released from the conjugate by treatment with deuterated hydrochloric acid DCl at pH = 1.5 for 10 h at 37 °C.
authors: Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383, Wroclaw, Poland.
authors: Tomasz
authors: T
authors: Han
authors: Józef
authors: J
authors: Utko
authors: Lucjan B
authors: LB
authors: Jerzykiewicz
authors: Piotr
authors: P
authors: Sobota
mesh_terms: D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D018360:Crystallography, X-Ray; D008274:Magnesium / Q000737:chemistry*; D008968:Molecular Conformation; D011091:Polyesters / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D011091:Polyesters; C033616:poly(lactide); D008274:Magnesium