title: Serum Interleukin-6, insulin, and HOMA-IR in male individuals with colorectal adenoma.
abstract: OBJECTIVE
  It is widely acknowledged that chronic low-grade inflammation plays a key role in the development of obesity-related insulin resistance and type 2 diabetes. The level of circulating interleukin-6 (IL-6), one of the major proinflammatory adipokines, is correlated with obesity and insulin resistance, which are known to be risk factors for colorectal adenoma. We examined the association between the circulating level of IL-6 and the presence of colorectal adenoma.
  
  
  METHODS
  In a total colonoscopy-based cross-sectional study conducted between January and December 2008, serum levels of IL-6 were measured in samples of venous blood obtained from 336 male participants attending health checkups (118 individuals with colorectal adenoma and 218 age-matched controls) after an overnight fast.
  
  
  RESULTS
  In the colorectal adenoma group, the median levels of serum IL-6 (1.24 vs. 1.04 pg/mL; P = 0.01), triglyceride, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) were to be significantly higher than those in the control group. When restricted to individuals with adenoma, levels of IL-6 were positively correlated with body mass index, insulin, and HOMA-IR. Multiple logistic analyses adjusted to include insulin or HOMA-IR showed that high levels of IL-6 were associated with the presence of colorectal adenoma. There was no significant interaction of IL-6 with HOMA-IR to modify this association.
  
  
  CONCLUSIONS
  Our findings suggest that increased serum levels of IL-6 are positively associated with the presence of colorectal adenoma in men, independently of insulin and HOMA-IR.
authors: Department of Gastroenterology, Faculty of Medicine, Yamagata University, Yamagata, Japan. y-sasaki@med.id.yamagata-u.ac.jp
authors: Yu
authors: Y
authors: Sasaki
authors: Hiroaki
authors: H
authors: Takeda
authors: Takeshi
authors: T
authors: Sato
authors: Tomohiko
authors: T
authors: Orii
authors: Shoichi
authors: S
authors: Nishise
authors: Ko
authors: K
authors: Nagino
authors: Daisuke
authors: D
authors: Iwano
authors: Takao
authors: T
authors: Yaoita
authors: Kazuya
authors: K
authors: Yoshizawa
authors: Hideki
authors: H
authors: Saito
authors: Yasuhisa
authors: Y
authors: Tanaka
authors: Sumio
authors: S
authors: Kawata
mesh_terms: D000236:Adenoma / Q000097:blood*; D000328:Adult; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D012680:Sensitivity and Specificity
chemical_list: C508600:IL6 protein, human; D007328:Insulin; D015850:Interleukin-6