title: [Short-tau inversion-recovery (STIR) sequence magnetic resonance imaging evaluation of orbital structures in Graves' orbitopathy].
abstract: OBJECTIVE
  To evaluate the orbital structures and to establish correlations with disease activity and severity in patients with Graves' hyperthyroidism and orbitopathy (GO) using short-tau inversion-recovery (STIR) sequence magnetic resonance imaging (MRI).
  
  
  METHODS
  Observational, cross-sectional, case-control study. Twenty-eight patients with euthyroid status after treatment and GO (GO group) and 15 control subjects (control group) were included. Patients underwent a complete ophthalmologic examination and were then assessed according to the EUGOGO (European Group on Graves' Orbitopathy) recommendations. Muscle cross-sectional areas, orbital tissue volumes and the signal intensity ratio (SIR) from the most inflamed extraocular muscle were calculated using a STIR-T2 weighted sequence MRI. Correlations between clinical and MRI measurements were analyzed.
  
  
  RESULTS
  Enlargements in the cross-sectional areas and volumes were significant for most EOMs (P<.001), but not for the lateral rectus muscle cross-sectional area. A significant difference in SIR values between patients with GO and control subjects (P<.001) was found. No significant correlations were found between muscle cross-sectional areas, orbital tissue volumes, SIR values and the clinical activity parameters.
  
  
  CONCLUSIONS
  Given the small sample size of our study, with the obvious need for larger clinical trials, we were unable to demonstrate that the STIR sequences in MRI are a sensitive tool in assessing patients with longstanding GO in order to detect inflammatory changes and activity follow-up, possibly because it is in inactive phase. Meanwhile, it is still necessary to continue performing a thorough clinical evaluation in the therapeutic management of GO.
authors: Servicio de Oftalmología, Hospital General Universitario de Guadalajara, Guadalajara.
authors: N
authors: N
authors: Rodríguez-González
authors: C
authors: C
authors: Pérez-Rico
authors: R
authors: R
authors: López-Para Giménez
authors: J
authors: J
authors: Arévalo-Serrano
authors: B
authors: B
authors: Del Amo García
authors: L
authors: L
authors: Calzada Domingo
authors: L
authors: L
authors: Flores Ruiz
authors: R
authors: R
authors: Blanco
mesh_terms: D000328:Adult; D000368:Aged; D013956:Antithyroid Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006111:Graves Disease / Q000188:drug therapy / Q000601:surgery; D049970:Graves Ophthalmopathy / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009801:Oculomotor Muscles / Q000473:pathology; D009915:Orbit / Q000473:pathology*; D009929:Organ Size; D013965:Thyroidectomy
chemical_list: D013956:Antithyroid Agents