title: Chemical synthesis of polyprenyl sialyl phosphate, a probable biosynthetic intermediate of bacterial polysialic acid.
abstract: Using reaction of moraprenyl phosphate with the known N-acetylsialyl chloride and the novel N,N-diacetylsialyl (Neu5Ac(2)) chloride α- and β-anomers of polyprenyl sialyl phosphate were synthesized for the first time. The α-selectivity dramatically increased when Neu5Ac(2) chloride was used as the glycosyl donor.
authors: N. D. Zelinsky Institute of Organic Chemistry of The Russian Academy of Sciences, Leninsky prosp., 47, Moscow 119991, Russian Federation.
authors: Anna M
authors: AM
authors: Shpirt
authors: Leonid O
authors: LO
authors: Kononov
authors: Sergey D
authors: SD
authors: Maltsev
authors: Vladimir N
authors: VN
authors: Shibaev
mesh_terms: D001419:Bacteria / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure; D011106:Polyisoprenyl Phosphates / Q000096:biosynthesis / Q000138:chemical synthesis* / Q000737:chemistry; D012794:Sialic Acids / Q000096:biosynthesis / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D011106:Polyisoprenyl Phosphates; D012794:Sialic Acids; C021319:polysialic acid