title: Thrombotic thrombocytopenic purpura.
abstract: In 1924, Dr Eli Moschcowitz described a 16-year-old adolescent girl with abrupt onset of petechiae, hemolytic anemia, followed by paralysis, coma, and death. Autopsy showed widespread hyaline thrombi in the terminal arterioles and capillaries of various organs. The syndrome described by Moschowitz is now known as thrombotic thrombocytopenic purpura.
authors: Department of Emergency Medicine, Brigham and Women's Hospital and Massachusetts General Hospital, Boston, MA 02115, USA. akoyfman@partners.org
authors: Alex
authors: A
authors: Koyfman
authors: Elizabeth
authors: E
authors: Brém
authors: Vincent W
authors: VW
authors: Chiang
mesh_terms: D051722:ADAM Proteins / Q000172:deficiency / Q000235:genetics; D000071120:ADAMTS13 Protein; D002648:Child; D003937:Diagnosis, Differential; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis; D006463:Hemolytic-Uremic Syndrome / Q000175:diagnosis; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D010949:Plasma; D010951:Plasma Exchange; D017713:Platelet Transfusion; D011697:Purpura, Thrombotic Thrombocytopenic / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy
chemical_list: D007166:Immunosuppressive Agents; D051722:ADAM Proteins; D000071120:ADAMTS13 Protein; C099604:ADAMTS13 protein, human