title: TNF-alpha and CXCL-10 correlation with insulin resistance in patients with chronic hepatitis C virus infection.
abstract: There are increasing reports of association between HCV infection and type-2 diabetes mellitus. Although the mechanism by which this association remains uncertain, development of insulin resistance may explain this association. We investigated the association of TNF-alpha and CXCL-10 with insulin resistance in HCV infected patients. Forty-four non-diabetic chronic hepatitis C patients and twenty healthy individuals were included. Fasting blood was used for glucose and insulin measurements. Diagnosis of insulin resistance (IR) was based on a mathematical means by the homeostasis model assessment score-insulin resistance index (HOMA-IR). Serum insulin, TNF-alpha and CXCL-10 levels were measured by enzyme linked immunosorbent assay (ELISA). Quantitative measurement of hepatitis C virus was performed by a standardized real time PCR assay. The HCV patients demonstrated a significant increase in serum TNF-alpha, CXCL-10, and HOMA-IR values as compared to normal controls. HOMA-IR level positively correlated with hepatitis C viral load, TNF-alpha and CXCL-10. It is concluded that, TNF-alpha, CXCL-10 correlate with IR and may play a role in the development of type-2 diabetes mellitus in chronic hepatitis C infected patients.
authors: Department of Internal Medicine, Tanta University Hospital, Faculty of Medicine, Tanta, Egypt.
authors: Laila
authors: L
authors: Sayed-Ahmed
authors: Nesreen
authors: N
authors: Kotb
authors: Hesham
authors: H
authors: El-Serogy
authors: Sherin
authors: S
authors: El-Shazly
authors: Manal
authors: M
authors: Eid
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D054357:Chemokine CXCL10 / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000821:virology; D005215:Fasting / Q000097:blood; D005260:Female; D016174:Hepacivirus / Q000302:isolation & purification*; D019698:Hepatitis C, Chronic / Q000097:blood* / Q000821:virology; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D019562:Viral Load / Q000379:methods
chemical_list: C114753:CXCL10 protein, human; D054357:Chemokine CXCL10; D007328:Insulin; D014409:Tumor Necrosis Factor-alpha