title: Posttraumatic mossy fiber sprouting is related to the degree of cortical damage in three mouse strains.
abstract: Controlled cortical impact injury was used to examine relationships between focal posttraumatic cortical damage and mossy fiber sprouting (MFS) in the dentate gyrus in three mouse strains. Posttraumatic MFS was more robust when cortical injury impinged upon the hippocampus, versus contusions restricted to neocortex, and was qualitatively similar among CD-1, C57BL/6, and FVB/N background strains. Impact parameters influencing injury severity may be critical in reproducing epilepsy-related changes in neurotrauma models.
authors: Department of Physiology, University of Kentucky, Lexington, KY 40536-0298, USA.
authors: Robert F
authors: RF
authors: Hunt
authors: Laura A
authors: LA
authors: Haselhorst
authors: Kathleen M
authors: KM
authors: Schoch
authors: Eva C
authors: EC
authors: Bach
authors: Jennifer
authors: J
authors: Rios-Pilier
authors: Stephen W
authors: SW
authors: Scheff
authors: Kathryn E
authors: KE
authors: Saatman
authors: Bret N
authors: BN
authors: Smith
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000150:complications / Q000235:genetics* / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D019599:Mossy Fibers, Hippocampal / Q000473:pathology*; D013045:Species Specificity