title: Neurologic signs in relation to cognitive function in subcortical ischemic vascular dementia: a CREDOS (Clinical Research Center for Dementia of South Korea) study.
abstract: The objective of this study was to investigate the relationship between neurologic signs and cognitive dysfunction in subcortical ischemic vascular dementia (SIVD). 121 patients with SIVD were recruited from multiple nationwide hospitals. The patients' neurologic signs were evaluated using the Focal Neurologic Sign Score (FNSS). The FNSS scores did not correlate with the composite neuropsychology scores and Korean Mini-Mental State Examination scores. The FNSS scores correlated with the letter fluency and Rey-Osterrieth Complex Figure (ROCF) copy scores. Using a multivariate regression analysis controlled for age, sex, and educational level, the FNSS scores had a significant relationship with the letter fluency test scores (R (2) = 0.08, β = -2.28, p = 0.02) and ROCF copy scores (R (2) = 0.08, β = -0.42, p = 0.03). These findings suggest that the neurologic signs in patients with SIVD do not correlate with global cognitive functions; however, these signs do correlate with executive dysfunction in these patients.
authors: Department of Neurology, Inha University School of Medicine, Incheon, South Korea.
authors: Seong Hye
authors: SH
authors: Choi
authors: Sangyun
authors: S
authors: Kim
authors: Seol-Heui
authors: SH
authors: Han
authors: Duk L
authors: DL
authors: Na
authors: Doh-Kwan
authors: DK
authors: Kim
authors: Hae-Kwan
authors: HK
authors: Cheong
authors: Jae-Hong
authors: JH
authors: Lee
authors: Seong Yoon
authors: SY
authors: Kim
authors: Chang Hyung
authors: CH
authors: Hong
authors: So Young
authors: SY
authors: Moon
authors: Jay C
authors: JC
authors: Kwon
authors: Jung Eun
authors: JE
authors: Kim
authors: Jee H
authors: JH
authors: Jeong
authors: Hae Ri
authors: HR
authors: Na
authors: Kyung Ryeol
authors: KR
authors: Cha
authors: Sang Won
authors: SW
authors: Seo
authors: Yong S
authors: YS
authors: Shim
authors: Jun-Young
authors: JY
authors: Lee
authors: Kyung Won
authors: KW
authors: Park
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D015140:Dementia, Vascular / Q000150:complications* / Q000453:epidemiology; D056344:Executive Function / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D009422:Nervous System Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D056910:Republic of Korea / Q000453:epidemiology