title: Development of inhibitors in haemophilia. Ongoing epidemiological study.
abstract: A number of 513 consecutive patients (494-haemophilia A and 19-haemophilia B) from eight haemophilia treatment centers have been investigated with Bethesda assay for the presence of factor VIII or IX inhibitors. The overall prevalence of inhibitors was 15.20%, 18.48% in severe, 5.60% in moderate and 12.24% in mild forms. The prevalence was higher than reported in most of the western countries. The age at start of substitution (p = 0.9775), the frequent switching of factor concentrates (p = 0.8931) were not relevant factors for the development of inhibitors. It is worth to be mentioned the unexpectedly occurrence of inhibitors in prior inhibitor negative (6/72) patients (during surgical interventions) probably due to their previous scarce substitution, occurrence which seems not being connected with the continuous infusion modality of factor VIII administration (p = 0.8341). In controversial situations, in the field of low titer (≤ 1 BU/ml) inhibitors for a reliable interpretation of the results the performance of recovery index and half-life time assessment of FVIII/IX was undertaken.
authors: University of Medicine and Pharmacy Victor Babes Timisoara, Rumänien. mserban@spitalcopiitm.ro
authors: M
authors: M
authors: Serban
authors: D
authors: D
authors: Mihailov
authors: L
authors: L
authors: Pop
authors: H
authors: H
authors: Ionita
authors: E
authors: E
authors: Ursu
authors: S
authors: S
authors: Talpos-Niculescu
authors: L
authors: L
authors: Ritli
authors: D
authors: D
authors: Baghiu
authors: V
authors: V
authors: Uscatescu
authors: C
authors: C
authors: Petrovanu
authors: P
authors: P
authors: Stancu
authors: D
authors: D
authors: Savescu
authors: A
authors: A
authors: Cucuianu
authors: W
authors: W
authors: Schramm
mesh_terms: D000328:Adult; D019774:Blood Coagulation Factor Inhibitors / Q000097:blood*; D005164:Factor IX / Q000032:analysis* / Q000037:antagonists & inhibitors*; D005169:Factor VIII / Q000032:analysis* / Q000037:antagonists & inhibitors*; D005260:Female; D005858:Germany / Q000453:epidemiology; D006467:Hemophilia A / Q000097:blood* / Q000453:epidemiology*; D006801:Humans; D008297:Male; D015995:Prevalence
chemical_list: D019774:Blood Coagulation Factor Inhibitors; D005169:Factor VIII; D005164:Factor IX