title: piR-823, a novel non-coding small RNA, demonstrates in vitro and in vivo tumor suppressive activity in human gastric cancer cells.
abstract: Piwi-interacting RNAs (piRNAs), new non-coding small RNAs, are association with chromatin organization, messenger RNA stability and genome structure. However, the roles of piRNA in carcinogenesis are not clearly defined. By using real-time reverse transcription-polymerase chain reaction technology, we found that the expression level of piR-823 in gastric cancer tissues was significant lower than that in non-cancerous tissues. After increase the level of piR-823 in gastric cancer cells, cell growth was inhibited. The results of xenograft nude mice model confirmed its tumor suppressive properties. All of the evidences indicated that piR-823 play a crucial role in the occult of gastric cancer.
authors: Ningbo University School of Medicine, China.
authors: Jia
authors: J
authors: Cheng
authors: Hongxia
authors: H
authors: Deng
authors: Bingxiu
authors: B
authors: Xiao
authors: Hui
authors: H
authors: Zhou
authors: Fei
authors: F
authors: Zhou
authors: Zhisen
authors: Z
authors: Shen
authors: Junming
authors: J
authors: Guo
mesh_terms: D000368:Aged; D000818:Animals; D048708:Cell Growth Processes / Q000235:genetics; D002460:Cell Line; D045744:Cell Line, Tumor; D015536:Down-Regulation; D005260:Female; D016147:Genes, Tumor Suppressor; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008875:Middle Aged; D058727:RNA, Small Untranslated / Q000008:administration & dosage* / Q000096:biosynthesis* / Q000235:genetics; D013274:Stomach Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D014162:Transfection; D023041:Xenograft Model Antitumor Assays
chemical_list: D058727:RNA, Small Untranslated