title: Garlicnin A from the fraction regulating macrophage activation of Allium sativum.
abstract: Garlicnin A (1), a new stable, sulfur-containing compound isolated from a fraction of the acetone extracts of Allium sativum L. garlic bulbs, showed the potential to suppress tumor cell proliferation by inhibiting the polarization of M2 alternatively activated macrophages, and its structure was characterized as 3,4-dimethyl-5-(4,5-dithia-1E,7-octadiene)-tetrahydrothiophene-2-sulfoxide-S-oxide, on the basis of the results of spectroscopic analysis results.
authors: Faculty of Pharmacy, Tanta University, Egypt.
authors: Mona
authors: M
authors: El-Aasr
authors: Yukio
authors: Y
authors: Fujiwara
authors: Motohiro
authors: M
authors: Takeya
authors: Masateru
authors: M
authors: Ono
authors: Daisuke
authors: D
authors: Nakano
authors: Masafumi
authors: M
authors: Okawa
authors: Junei
authors: J
authors: Kinjo
authors: Tsuyoshi
authors: T
authors: Ikeda
authors: Hiroyuki
authors: H
authors: Miyashita
authors: Hitoshi
authors: H
authors: Yoshimitsu
authors: Toshihiro
authors: T
authors: Nohara
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005737:Garlic / Q000737:chemistry*; D006801:Humans; D008262:Macrophage Activation / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D018517:Plant Roots / Q000737:chemistry; D011956:Receptors, Cell Surface / Q000378:metabolism; D013876:Thiophenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000098902:CD163 Antigen
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D000972:Antineoplastic Agents, Phytogenic; D000098902:CD163 Antigen; D011956:Receptors, Cell Surface; D013876:Thiophenes; C570310:garlicnin A