title: Screening for prostate cancer: early detection or overdetection?
abstract: A sophisticated reading of the randomized trial evidence suggests that, although screening for prostate cancer with prostate-specific antigen (PSA) can reduce cancer-specific mortality, it does so at considerable cost in terms of the number of men who need to be screened, biopsied, and treated to prevent one death. The challenge is to design screening programs that maximize benefits (reducing prostate cancer mortality) and minimize costs (overtreatment). Recent research has suggested that this can be achieved by risk-stratifying screening and biopsy; increasing reliance on active surveillance for low-risk cancer; restricting radical prostatectomy to high-volume surgeons; and using appropriately high-dose radiotherapy. In current U.S. practice, however, many men who are screened are unlikely to benefit, most men found to have low-risk cancers are referred for unnecessary curative treatment, and much treatment is given at low-volume centers.
authors: Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA. vickersa@mskcc.org
authors: Andrew J
authors: AJ
authors: Vickers
authors: Monique J
authors: MJ
authors: Roobol
authors: Hans
authors: H
authors: Lilja
mesh_terms: D042241:Early Diagnosis; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000592:standards* / Q000706:statistics & numerical data; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D019564:Unnecessary Procedures / Q000592:standards* / Q000706:statistics & numerical data