title: Smarter drugs: a focus on pan-specific monoclonal antibodies.
abstract: Antibodies capable of targeting more than one antigen are envisioned to expand therapeutic efficacy in complex disease settings. Several strategies have been developed to achieve multiple targeting, including antibody mixtures and bispecific formats. In recent years, several dual- and pan-specific antibodies have been described and represent an alternative approach. These antibodies bind to different targets using a single antigen-combining site while maintaining high affinity and specificity, thus challenging the 'one antibody, one antigen' dogma. Despite certain drawbacks, the simple IgG format of this drug class enables rapid progression into the clinic.
authors: NovImmune SA, Plan-les-Ouates, Switzerland.
authors: Séverine
authors: S
authors: Fagète
authors: Nicolas
authors: N
authors: Fischer
mesh_terms: D000818:Animals; D018033:Antibodies, Bispecific / Q000276:immunology* / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000276:immunology* / Q000627:therapeutic use*; D000918:Antibody Specificity / Q000276:immunology*; D001666:Binding Sites, Antibody / Q000276:immunology; D003429:Cross Reactions / Q000276:immunology; D006801:Humans
chemical_list: D018033:Antibodies, Bispecific; D000911:Antibodies, Monoclonal