title: Altered phosphate metabolism in HIV-1-infected patients with metabolic syndrome.
abstract: BACKGROUND
  Metabolic syndrome (MS) represents a cluster of cardiovascular risk factors that has become a serious problem for HIV-1-infected patients. It has been proposed that disturbance of phosphate metabolism may represent a key feature of MS. Thus, we undertook the present study to investigate the relationship between phosphate levels and the presence of the characteristics of MS.
  
  
  METHODS
  One hundred and twenty-one HIV-1-infected patients were consecutively enrolled in a prospective, cross-sectional, single-centre study. Kidney tubular function was examined using tubular resorption of phosphate and normalized renal threshold phosphate concentration.
  
  
  RESULTS
  Univariate analysis showed that serum phosphate levels correlated negatively with systolic and diastolic blood pressure, glucose values, waist circumference, insulin, and triglycerides. Moreover, there was a positive relationship between phosphate and high-density lipoprotein (HDL) cholesterol. Multivariate analysis showed that insulin levels were correlated with serum phosphate concentration (r = - 0.24, p = 0.01).
  
  
  CONCLUSIONS
  Our data show that HIV-1-infected patients with MS have lower phosphate levels.
authors: Division of Infectious Diseases, HIV Centre, S. Caterina Novella Hospital, via Roma, Galatina, Italy. pierfrancescogrima@yahoo.it
authors: Pierfrancesco
authors: P
authors: Grima
authors: Marcello
authors: M
authors: Guido
authors: Roberto
authors: R
authors: Chiavaroli
authors: Francesca
authors: F
authors: Stano
authors: Paolo
authors: P
authors: Tundo
authors: Mariangela
authors: M
authors: Tana
authors: Antonella
authors: A
authors: de Donno
authors: Antonella
authors: A
authors: Zizza
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000378:metabolism; D015497:HIV-1; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000378:metabolism*; D008875:Middle Aged; D016017:Odds Ratio; D010710:Phosphates / Q000097:blood / Q000378:metabolism*; D055815:Young Adult
chemical_list: D010710:Phosphates