title: The conversion of nickel-bound CO into an acetyl thioester: organometallic chemistry relevant to the acetyl coenzyme A synthase active site.
abstract: When three become one: Within one nickel-based model system, the three reactants CO, MeI, and PhSH have been assembled to yield an acetyl thioester. The reactivity is of relevance for the functioning of the acetyl coenzyme A synthase active site and provides insights into possible binding sequences.
authors: Humboldt-Universität zu Berlin, Institut für Chemie, Brook-Taylor-Straße 2, 12489 Berlin, Germany.
authors: Bettina
authors: B
authors: Horn
authors: Christian
authors: C
authors: Limberg
authors: Christian
authors: C
authors: Herwig
authors: Stefan
authors: S
authors: Mebs
mesh_terms: D000445:Aldehyde Oxidoreductases / Q000737:chemistry / Q000378:metabolism*; D002248:Carbon Monoxide / Q000737:chemistry / Q000378:metabolism*; D020134:Catalytic Domain; D009097:Multienzyme Complexes / Q000737:chemistry / Q000378:metabolism*; D009532:Nickel / Q000737:chemistry / Q000378:metabolism*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry / Q000378:metabolism*
chemical_list: D009097:Multienzyme Complexes; D009942:Organometallic Compounds; D013438:Sulfhydryl Compounds; D009532:Nickel; D002248:Carbon Monoxide; D000445:Aldehyde Oxidoreductases; C019823:carbon monoxide dehydrogenase