title: Stereoselective synthesis of C-substituted morpholine derivatives using reductive etherification reaction: total synthesis of chelonin C.
abstract: A general strategy is developed for the stereoselective synthesis of C-substituted morpholine derivatives using intramolecular reductive etherification reaction. The method is extended to the first stereoselective total synthesis of (±)-chelonin C.
authors: Department of Chemistry, Indian Institute of Technology Madras, Chennai-600036, Tamil Nadu, India. sjgharpure@iitm.ac.in
authors: Santosh J
authors: SJ
authors: Gharpure
authors: J V K
authors: JV
authors: Prasad
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis*; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis*; D060326:Chemistry Techniques, Synthetic; D004951:Esterification; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009025:Morpholines / Q000138:chemical synthesis*; D010084:Oxidation-Reduction; D013141:Spiro Compounds / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D001688:Biological Products; D001643:Bridged Bicyclo Compounds; D009025:Morpholines; D013141:Spiro Compounds