title: Effect of glutamine on the total antioxidant system of rats subjected to renal ischemia and reperfusion.
abstract: OBJECTIVE
  To evaluate the protective effects of glutamine administered before renal ischemia-reperfusion on plasma antioxidant protection, and lung and renal tissue injury.
  
  
  METHODS
  33 rats underwent right nephrectomy. On the eighth postoperative day, animals were randomized into three groups (n=11): glutamine, control and sham. Each group of animals received, by gavage, a particular diet for 7 days. On day 14 following nephrectomy, the animals were subjected to left renal ischemia-reperfusion. After this, blood samples were collected and the animals were killed. At necropsy the kidney and lung were removed for histology.
  
  
  RESULTS
  The levels of total antioxidant capacity were higher in the glutamine group and control group compared with the sham group. The levels of glutathione peroxidase in both the sham and glutamine groups were higher when compared with the control group (p<0.05). The level of superoxide dismutase in the sham group was clearly higher than that in the glutamine and control groups. Histological examination showed no differences between the three groups.
  
  
  CONCLUSIONS
  Prior intake of glutamine improves total antioxidant capacity and increases glutathione peroxidase levels in rats subjected to renal ischemia-reperfusion.
authors: Clinical Surgery Department, Julio Muller Hospital, UFMT, Mato Grosso, Brazil. Valter.junior@sbu.org.br
authors: Valter Torezan
authors: VT
authors: Gouvêa Junior
authors: Cervantes
authors: C
authors: Caporossi
authors: Alberto Bicudo
authors: AB
authors: Salomão
authors: Erlon
authors: E
authors: Côrtes
authors: Marina Francine
authors: MF
authors: Munhoz
authors: José Eduardo Aguilar de
authors: JE
authors: Nascimento
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood; D005973:Glutamine / Q000627:therapeutic use*; D005979:Glutathione Peroxidase / Q000097:blood; D007668:Kidney / Q000098:blood supply* / Q000473:pathology; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008168:Lung / Q000473:pathology; D055370:Lung Injury / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009392:Nephrectomy; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D005973:Glutamine; D003404:Creatinine; D007770:L-Lactate Dehydrogenase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase