title: [Plasma levels of VEGF-C, VEGF-D, VEGFR-2 and VEGFR-3 in patients with newly diagnosed lymphomas].
abstract: The objective of this study was to detect the expression levels of VEGF-C, VEGF-D, VEGFR-2 and VEGFR-3 in plasma of newly diagnosed lymphoma patients, and analyze their possible relationships with clinicopathological characteristics and prognosis. The expression levels of VEGF-C, VEGF-D, VEGFR-2 and VEGFR-3 in plasma from 86 newly diagnosed lymphoma patients were detected by enzyme-linked immunosorbent assay (ELISA). As a results, the multivariate analysis showed that VEGF-C level in non-Hodgkin's lymphoma patients was low, but high in Hodgkin's lymphoma patients; VEGFR-2 level was higher in patients > 60 years, while VEGF-D level was lower in patients with IPI > 2. The univariate analysis showed that VEGF-D level was lower in patients with IPI > 2, while VEGF-D and VEGF-C levels were higher in patients without B symptoms. Relationship analysis between these factors indicated that the relation of VEGF-D expression level with VEGFR-2 and VEGFR-3 was positive. It is concluded that VEGF-C, VEGF-D, VEGFR-2 and VEGFR-3 play important roles in the pathogenesis of lymphoma, and may be used as indicators of prognosis evaluation or even guide for the antiangiogenesis treatment of lymphoma.
authors: Department of Hematology, Peking University Shougang Hospital, Beijing, China.
authors: Fang
authors: F
authors: Liu
authors: Yu-Qin
authors: YQ
authors: Song
authors: Chen
authors: C
authors: Zhang
authors: Zhi-Ying
authors: ZY
authors: Fu
authors: Ling-Yan
authors: LY
authors: Ping
authors: Zhi-Tao
authors: ZT
authors: Ying
authors: Wen
authors: W
authors: Zheng
authors: Xiao-Pei
authors: XP
authors: Wang
authors: Yan
authors: Y
authors: Xie
authors: Ning-Jing
authors: NJ
authors: Lin
authors: Mei-Feng
authors: MF
authors: Tu
authors: Jun
authors: J
authors: Zhu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000097:blood* / Q000175:diagnosis / Q000473:pathology*; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D042582:Vascular Endothelial Growth Factor C / Q000097:blood; D042643:Vascular Endothelial Growth Factor D / Q000097:blood; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000097:blood; D040321:Vascular Endothelial Growth Factor Receptor-3 / Q000097:blood; D055815:Young Adult
chemical_list: D042582:Vascular Endothelial Growth Factor C; D042643:Vascular Endothelial Growth Factor D; D040301:Vascular Endothelial Growth Factor Receptor-2; D040321:Vascular Endothelial Growth Factor Receptor-3