title: Reduced amygdala-orbitofrontal connectivity during moral judgments in youths with disruptive behavior disorders and psychopathic traits.
abstract: We used functional magnetic resonance imaging (fMRI) to investigate dysfunction in the amygdala and orbitofrontal cortex in adolescents with disruptive behavior disorders and psychopathic traits during a moral judgment task. Fourteen adolescents with psychopathic traits and 14 healthy controls were assessed using fMRI while they categorized illegal and legal behaviors in a moral judgment implicit association task. fMRI data were then analyzed using random-effects analysis of variance and functional connectivity. Youths with psychopathic traits showed reduced amygdala activity when making judgments about legal actions and reduced functional connectivity between the amygdala and orbitofrontal cortex during task performance. These results suggest that psychopathic traits are associated with amygdala and orbitofrontal cortex dysfunction. This dysfunction may relate to previous findings of disrupted moral judgment in this population.
authors: Mood & Anxiety Program, National Institute of Mental Health, Bethesda, MD, USA; Department of Psychology, Georgetown University, Washington DC, USA. Electronic address: aam72@georgetown.edu.
authors: Abigail A
authors: AA
authors: Marsh
authors: Department of Clinical Neurological Sciences, University of Western Ontario, London, ON, Canada.
authors: Elizabeth C
authors: EC
authors: Finger
authors: Mood & Anxiety Program, National Institute of Mental Health, Bethesda, MD, USA.
authors: Katherine A
authors: KA
authors: Fowler
authors: Mood & Anxiety Program, National Institute of Mental Health, Bethesda, MD, USA.
authors: Ilana T N
authors: ITN
authors: Jurkowitz
authors: Department of Psychology, Emory University, Atlanta, GA, USA.
authors: Julia C
authors: JC
authors: Schechter
authors: Mood & Anxiety Program, National Institute of Mental Health, Bethesda, MD, USA.
authors: Henry H
authors: HH
authors: Yu
authors: Mood & Anxiety Program, National Institute of Mental Health, Bethesda, MD, USA.
authors: Daniel S
authors: DS
authors: Pine
authors: Mood & Anxiety Program, National Institute of Mental Health, Bethesda, MD, USA.
authors: R J R
authors: RJR
authors: Blair
mesh_terms: D000293:Adolescent; D000679:Amygdala / Q000098:blood supply*; D000704:Analysis of Variance; D000987:Antisocial Personality Disorder / Q000473:pathology / Q000503:physiopathology / Q000523:psychology; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000473:pathology / Q000503:physiopathology / Q000523:psychology; D001931:Brain Mapping; D002648:Child; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007600:Judgment; D008279:Magnetic Resonance Imaging; D008297:Male; D009014:Morals; D009434:Neural Pathways / Q000098:blood supply; D010100:Oxygen / Q000097:blood; D010555:Personality Inventory; D017397:Prefrontal Cortex / Q000098:blood supply*; D011569:Psychiatric Status Rating Scales
chemical_list: D010100:Oxygen