title: Craniosynostosis following hemispherectomy in a 2.5-month-old boy with intractable epilepsy.
abstract: The authors report on the case of a 6-week-old boy who presented with infantile spasms. At 2.5 months of age, the patient underwent a right hemispherectomy. Approximately 3 months postoperatively, the patient presented with left coronal craniosynostosis. Subsequent cranial vault remodeling resulted in satisfactory cosmesis. Four years after surgery, the patient remains seizure free without the need for anticonvulsant medications. The authors believe this to be the first reported case of iatrogenic craniosynostosis due to hemispherectomy, and they describe 2 potential mechanisms for its development. This case suggests that, in the surgical treatment of infants with intractable epilepsy, minimization of brain volume loss through disconnection techniques should be considered, among other factors, when determining the best course of action.
authors: Department of Neurosurgery, Medical College of Wisconsin/Children's Hospital of Wisconsin, Milwaukee, Wisconsin, USA.
authors: Mohammad-Ali
authors: MA
authors: Jazayeri
authors: John N
authors: JN
authors: Jensen
authors: Sean M
authors: SM
authors: Lew
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use; D000927:Anticonvulsants / Q000627:therapeutic use; D002998:Clonazepam / Q000627:therapeutic use; D003398:Craniosynostoses / Q000209:etiology* / Q000601:surgery*; D003399:Craniotomy; D004569:Electroencephalography; D004827:Epilepsy / Q000601:surgery*; D005632:Fructose / Q000031:analogs & derivatives / Q000627:therapeutic use; D038421:Hemispherectomy / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D008297:Male; D011183:Postoperative Complications / Q000601:surgery*; D013036:Spasms, Infantile / Q000150:complications / Q000601:surgery; D014057:Tomography, X-Ray Computed; D000077236:Topiramate
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose; D002998:Clonazepam; D000324:Adrenocorticotropic Hormone