title: Serglycin: a structural and functional chameleon with wide impact on immune cells.
abstract: Among the different proteoglycans expressed by mammals, serglycin is in most immune cells the dominating species. A unique property of serglycin is its ability to adopt highly divergent structures, because of glycosylation with variable types of glycosaminoglycans when expressed by different cell types. Recent studies of serglycin-deficient animals have revealed crucial functions for serglycin in a diverse array of immunological processes. However, its exact function varies to a large extent depending on the cellular context of serglycin expression. Based on these findings, serglycin is emerging as a structural and functional chameleon, with radically different properties depending on its exact cellular and immunological context.
authors: Department of Nutrition, University of Oslo, 0316 Oslo, Norway. s.o.kolset@medisin.uio.no
authors: Svein O
authors: SO
authors: Kolset
authors: Gunnar
authors: G
authors: Pejler
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D007107:Immune System / Q000737:chemistry / Q000166:cytology* / Q000378:metabolism; D011509:Proteoglycans / Q000096:biosynthesis / Q000737:chemistry* / Q000502:physiology*; D022142:Secretory Vesicles / Q000276:immunology / Q000378:metabolism; D013329:Structure-Activity Relationship; D033921:Vesicular Transport Proteins / Q000096:biosynthesis / Q000737:chemistry* / Q000502:physiology*
chemical_list: D011509:Proteoglycans; D033921:Vesicular Transport Proteins; C075430:serglycin