title: PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer.
abstract: Alcohol is a risk factor for postmenopausal breast cancer. One of several proposed mechanisms is that alcohol-related breast cancer is caused by increased sex hormone levels. PPARγ inhibits aromatase transcription in breast adipocytes. We reproduced previously found allele-specific effects of the wildtype Pro-allele of PPARG Pro(12)Ala in alcohol related breast cancer. In transiently transfected cells, transcriptional activation by PPARγ and the PPARγ-PGC-1α complex was inhibited by ethanol. PPARγ 12Ala-mediated transcription activation was not enhanced by PGC-1α, resulting in allele-specific transcription activation by the PPARγ 12Pro-PGC-1α complex. Our results suggest that PPARγ and PGC-1α activity is an important determinant of alcohol related breast cancer.
authors: Department of Biology, University of Copenhagen, Denmark.
authors: Rasmus Koefoed
authors: RK
authors: Petersen
authors: Signe Benzon
authors: SB
authors: Larsen
authors: Ditte Marie
authors: DM
authors: Jensen
authors: Jane
authors: J
authors: Christensen
authors: Anja
authors: A
authors: Olsen
authors: Steffen
authors: S
authors: Loft
authors: Christine
authors: C
authors: Nellemann
authors: Kim
authors: K
authors: Overvad
authors: Karsten
authors: K
authors: Kristiansen
authors: Anne
authors: A
authors: Tjønneland
authors: Ulla
authors: U
authors: Vogel
mesh_terms: D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects / Q000453:epidemiology* / Q000378:metabolism; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000378:metabolism; D003718:Denmark / Q000453:epidemiology; D000431:Ethanol / Q000506:poisoning; D005260:Female; D006360:Heat-Shock Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D047495:PPAR gamma / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D014157:Transcription Factors / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D006360:Heat-Shock Proteins; D047495:PPAR gamma; C486497:PPARGC1A protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D014157:Transcription Factors; D000431:Ethanol