title: Plasma oxidized low-density lipoprotein is an independent risk factor in young patients with coronary artery disease.
abstract: OBJECTIVE
  Oxidized low-density lipoprotein (ox-LDL) is considered to be a key factor of initiating and accelerating atherosclerosis. The objective of this study was to investigate the role of ox-LDL in young patients with coronary artery disease (CAD).
  
  
  METHODS
  128 consecutive angiographically proven young CAD patients (aged ⩽ 55 years) were enrolled, and 132 age-matched non-CAD individuals (coronary angiography normal or negative finding by coronary ultrafast CT) were set as control group. Conventional risk factors (hypertension, dyslipidemia, diabetes mellitus, obesity, smoking) were evaluated in the two groups. Ox-LDL was measured by competitive ELISA. Framingham risk score (FRS) and absolute 10-year CAD events risk were calculated for each individual.
  
  
  RESULTS
  Male sex was more prevalent in group CAD than in control (87.5% vs. 62.1%; P< 0.01). There were significant differences in smoking history (P< 0.01) and triglyeride (TG) and ratio of apolipoprotein B/apolipoprotein A1 (ApoB/ApoA1) (both P< 0.05) but no remarkable difference in other conventional risk factors (all P> 0.05) between group CAD and control. Level of ox-LDL was significantly higher in group CAD than in control (P< 0.01). Multivariate logistic regression showed that male sex (OR, 4.54; 95%CI, 1.76-9.77), smoking quantity (OR, 2.78; 95%CI, 1.34-4.25), TG (OR, 1.42; 95%CI, 1.18-2.83), ApoB/ApoA1 (OR, 1.73; 95%CI, 1.32-4.23), and ox-LDL (OR, 2.15; 95%CI, 1.37-6.95) were independently correlated with CAD in young patients. Area under the curve (AUC) of receiver operating characteristic (ROC) curve of TG, ApoB/ApoA1, and ox-LDL was 0.831, 0.866, and 0.935, respectively (P< 0.001).
  
  
  CONCLUSIONS
  Ox-LDL is an important independent risk factor for CAD in young patients after adjusting other risk factors such as smoking, TG, and ApoB/ApoA1.
authors: Department of Cardiology, the Affiliated Hospital at Shunde (the First People's Hospital of Shunde), Southern Medical University, P.R. China.
authors: Yuli
authors: Y
authors: Huang
authors: Yunzhao
authors: Y
authors: Hu
authors: Weiyi
authors: W
authors: Mai
authors: Xiaoyan
authors: X
authors: Cai
authors: Yuanbin
authors: Y
authors: Song
authors: Yanxian
authors: Y
authors: Wu
authors: Yugang
authors: Y
authors: Dong
authors: Huiling
authors: H
authors: Huang
authors: Zhongyun
authors: Z
authors: He
authors: Wensheng
authors: W
authors: Li
authors: You
authors: Y
authors: Yang
authors: Shaoqi
authors: S
authors: Rao
mesh_terms: D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000209:etiology; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012372:ROC Curve; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D014280:Triglycerides / Q000097:blood
chemical_list: C505693:APOA1 protein, human; D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D015415:Biomarkers; D008077:Lipoproteins, LDL; D014280:Triglycerides; C099252:oxidized low density lipoprotein