title: CONTINUOUS-TIME FILTERS FOR STATE ESTIMATION FROM POINT PROCESS MODELS OF NEURAL DATA.
abstract: Neural spike trains, the primary communication signals in the brain, can be accurately modeled as point processes. For many years, significant theoretical work has been done on the construction of exact and approximate filters for state estimation from point process observations in continuous-time. We have previously developed approximate filters for state estimation from point process observations in discrete-time and applied them in the study of neural systems. Here, we present a coherent framework for deriving continuous-time filters from their discrete-counterparts. We present an accessible derivation of the well-known unnormalized conditional density equation for state evolution, construct a new continuous-time filter based on a Gaussian approximation, and propose a method for assessing the validity of the approximation following an approach by Brockett and Clark. We apply these methods to the problem of reconstructing arm reaching movements from simulated neural spiking activity from the primary motor cortex. This work makes explicit the connections between adaptive point process filters for analyzing neural spiking activity in continuous-time, and standard continuous-time filters for state estimation from continuous and point process observations.
authors: Department of Mathematics and Statistics, 111 Cummington St., Boston University, Boston, MA 02215, U.S.A.  tzvi@bu.edu.
authors: Uri T
authors: UT
authors: Eden
authors: Emery N
authors: EN
authors: Brown