title: Bridge to recovery: what remains to be discovered?
abstract: The use of left ventricular assist devices to induce substantial myocardial recovery with explantation of the device, bridge to recovery (BTR), is an exciting but currently grossly underused application. Recently acquired knowledge relating to BTR and its mechanisms offers unprecedented opportunities to streamline its use and unravel some of the secrets of heart failure with much wider implications. This article reviews the status, challenges, and future of cardiac recovery.
authors: Heart Science Centre, Magdi Yacoub Institute, Harefield Hospital, London, UK.
authors: Michael
authors: M
authors: Ibrahim
authors: Cesare M
authors: CM
authors: Terracciano
authors: Magdi H
authors: MH
authors: Yacoub
mesh_terms: D017209:Apoptosis / Q000502:physiology; D003131:Combined Modality Therapy; D003598:Cytoskeletal Proteins / Q000378:metabolism; D020878:Device Removal; D022062:Electrophysiologic Techniques, Cardiac; D005109:Extracellular Matrix / Q000502:physiology; D006333:Heart Failure / Q000473:pathology / Q000534:rehabilitation / Q000628:therapy*; D006353:Heart-Assist Devices / Q000639:trends*; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism; D009200:Myocardial Contraction; D032383:Myocytes, Cardiac / Q000166:cytology / Q000502:physiology; D018579:Patient Selection; D011182:Postoperative Care / Q000379:methods; D011474:Prosthesis Design; D019919:Prosthesis Implantation / Q000379:methods; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D020127:Recovery of Function / Q000502:physiology; D013997:Time Factors
chemical_list: D003598:Cytoskeletal Proteins; D008565:Membrane Proteins; D011943:Receptors, Adrenergic, beta