title: Dose response for travoprost® in the glaucomatous beagle.
abstract: OBJECTIVE
  To evaluate the changes in intraocular pressure (IOP) and pupil size in 12 Beagles with inherited glaucoma after instillations of 0.033, 0.0033, 0.001, 0.00033, and 0.0001% travoprost (Travatan®-Alcon Laboratories, Inc., Ft Worth, TX, USA) in multiple single-dose studies.
  
  
  METHODS
  Intraocular pressure and pupil diameter (PD) measurements were obtained at 9 am, 12 pm, 3 pm, and 9 am the following day (24 h) in two groups of six glaucoma dogs. After 7 days, the vehicle or concentration was repeated in the contralateral eye of the same animals.
  
  
  RESULTS
  Concentrations of 0.00033, 0.001, and 0.0033% travoprost significantly lowered IOP and PD, but the 0.0001% concentration provided limited IOP changes, although PD changes were still significant. This suggests travoprost is effective in the dog to lower IOP and reduce pupil size at concentrations starting between 0.0001 and 0.00033%.
  
  
  CONCLUSIONS
  The dose response for travoprost in the glaucomatous Beagle indicates this model is highly sensitive to this group of drugs, even at concentrations as low as 0.00033% (1/12 the commercially available concentration).
authors: Department of Small Animal Clinical Sciences and Gwathmey-Adams Laboratory for Vision Research, College of Veterinary Medicine, University of Florida, PO Box 100126, Gainesville, FL 32610-0126, USA. eomackay@gmail.com
authors: Edward O
authors: EO
authors: Mackay
authors: Marsha
authors: M
authors: McLaughlin
authors: Caryn E
authors: CE
authors: Plummer
authors: Anna
authors: A
authors: Ben-Shlomo
authors: Kirk N
authors: KN
authors: Gelatt
mesh_terms: D000818:Animals; D003008:Cloprostenol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D018592:Cross-Over Studies; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D005901:Glaucoma / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D000069557:Travoprost
chemical_list: D003008:Cloprostenol; D000069557:Travoprost