title: Prognostic significance of p53 and KAI-1 expression in patients with laryngeal squamous cell carcinoma.
abstract: OBJECTIVE
  To examine the prognostic significance of the immunohistochemical expression of p53 and KAI-1 oncoproteins in patients with laryngeal squamous cell carcinoma.
  
  
  METHODS
  A retrospective evaluation was developed on 82 patients with primary laryngeal squamous cell carcinoma treated by primary surgery. For the immunohistochemical evaluation, formalin-fixed and paraffin-embedded tissue blocks from resection were used. Clinicopathologic data were correlated with the staining results.
  
  
  RESULTS
  The results of the immunohistochemical examination showed a statistically significant relationship between down-regulation of KAI-1 protein expression, increase of the histologic grading, and primary tumors associated with lymph node metastases. On the other hand, no statistical correlation was evidenced between p53 up-regulation and clinicopathologic data or between the two markers.
  
  
  CONCLUSIONS
  Our results suggest that KAI-1 may become an important biomarker that could help in selection of high-risk patients with laryngeal squamous cell carcinoma who may benefit from more aggressive therapy or chemoprevention.
authors: Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy. remassimo@hotmail.com
authors: Massimo
authors: M
authors: Re
authors: Giuseppe
authors: G
authors: Magliulo
authors: Eleonora
authors: E
authors: Salvolini
authors: Monia
authors: M
authors: Orciani
authors: Federico Maria
authors: FM
authors: Gioacchini
authors: Gaia
authors: G
authors: Goteri
authors: Corrado
authors: C
authors: Rubini
mesh_terms: D002294:Carcinoma, Squamous Cell; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms; D012189:Retrospective Studies; D016159:Tumor Suppressor Protein p53
chemical_list: D016159:Tumor Suppressor Protein p53