title: [Case of Fusobacterium necrophorum sepsis (Lemierre's syndrome) with pulmonary septic emboli and liver abscess].
abstract: The present article documents a case of Fusobacterium sepsis with a transient anticardiolipin antibody increase in an otherwise healthy 24-year-old patient. He was presented to the emergency room with headache and fever. His temperature was 39.5°C, laboratory results revealed a white blood count of 15.2×10(3)/μl and C reactive protein 22.6 mg/dl. The patient was admitted. Chest X-ray showed the infiltrate in bilateral lower lung area. He received 400 mg of clarithromycin per day. His all symptoms did not change. On the 8(th) day in the hospital, the patient's antibiotics were switched to pazufloxacin. Chest and abdominal CT scan showed some irregular patchy nodules of around 1 cm in diameter in the bilateral lower lung fields and a round low density lesion 3 cm in diameter in the right upper segment (S8) in the liver. Blood culture revealed Fusobacterium necrophorum. On the 10(th) day, the antibacterial agent was changed from pazufloxacin to ampicillin sulbactam. On the 17(th) day, we added clindamycin. As a result his temperature gradually returned to normal. It is reported that the titer of anticardiolipin antibody increases in the sepsis patients caused by Fusobacterium necrophorum. As his symptoms disappeared, his titer of anticardiolipin antibody also decreased. So we considered he had a transient anticardiolipin titer increase.
authors: The Department of Internal Medicine, Yokosuka General Hospital Uwamachi.
authors: Eiji
authors: E
authors: Yamamoto
authors: Tomoaki
authors: T
authors: Fukae
authors: Yasufumi
authors: Y
authors: Kawai
authors: Manabu
authors: M
authors: Kamio
authors: Hideki
authors: H
authors: Honda
authors: Sachiko
authors: S
authors: Fukumi
authors: Mitsuru
authors: M
authors: Nakagawa
authors: Keiichiro
authors: K
authors: Matsunaga
authors: Yuichi
authors: Y
authors: Numata
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D017153:Antibodies, Anticardiolipin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D057915:Drug Substitution; D005675:Fusobacterium necrophorum / Q000302:isolation & purification*; D006801:Humans; D057831:Lemierre Syndrome / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D008100:Liver Abscess / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D008297:Male; D011655:Pulmonary Embolism / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D017153:Antibodies, Anticardiolipin; D015415:Biomarkers