title: MMP7 -181G allele is a low-penetrant risk factor for cancer development in East Asians.
abstract: Matrix metalloproteinase-7 (MMP-7) is a small secreted proteolytic enzyme with broad substrate specificity. Its expression is associated with tumor invasion, metastasis, and survival for a number of cancers. However, data from published studies with individually low statistical power are conflicting. Here, we performed a meta-analysis of 14 publications (16 case-control studies) to better assess the purported relationship. Eligible studies were identified by searching the Pubmed database. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association. Overall, we found that the -181 G allele increased cancer risk in East Asians (G-allele vs. A-allele, OR=1.35, 95% CI: 1.25-1.46, P(heterogeneity)=0.01; GA vs. AA, OR=1.40, 95% CI: 1.16-1.69, P(heterogeneity)=0.04; GG+GA vs. AA, OR=1.52, 95% CI: 1.30-1.78, P(heterogeneity)=0.00). Similarly, in the stratified analysis by cancer type and source of control, significantly increased cancer risk was indicated. Our study showed evidence that MMP7 -181A/G polymorphism may increase cancer risk in the East Asian population. Future studies with larger sample size are warranted to further evaluate this association in greater detail.
authors: Department of Urology, Third Affiliated Hospital of Nantong University, Wuxi, China. miniao1984@163.com
authors: Mi
authors: M
authors: Yuan-Yuan
authors: Zhang
authors: Z
authors: Li-Feng
authors: Zhu
authors: Z
authors: Li-Jie
mesh_terms: D016022:Case-Control Studies; D005202:Asia, Eastern / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D020783:Matrix Metalloproteinase 7 / Q000235:genetics*; D015201:Meta-Analysis as Topic; D009369:Neoplasms / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors
chemical_list: C060932:MMP7 protein, human; D020783:Matrix Metalloproteinase 7