title: Endocrine late sequelae in long-term survivors of childhood non-Hodgkin lymphoma.
abstract: BACKGROUND
  Aim of this study was to investigate the long-term endocrine effects of treatment of childhood non-Hodgkin lymphoma (NHL).
  
  
  METHODS
  A single-center cohort of 84 survivors (22 females) was included in this retrospective study. Median age was 21 years (9-40 years) and time after cessation of therapy 12 years (4-30 years). Height, weight, percentage fat, lean body mass (LBM), bone mineral content (BMC), bone mineral density of total body (BMD(TB)) and bone mineral density of lumbar spine (BMD(LS)) were measured. Thyroid-stimulating hormone (TSH), free thyroxin (fT4), insulin-like growth factor-1 (IGF-1), inhibin B and anti-müllerian hormone (AMH) levels were measured. Results were compared with Dutch controls.
  
  
  RESULTS
  Height was lower in survivors [mean standard deviation score (SDS) -0.36, P = 0.002], but further analysis showed that shorter stature was already present at diagnosis (mean SDS -0.28, P = 0.023). Body mass index, percentage fat, BMC, BMD(TB) and BMD(LS) were not different from controls. LBM was lower in survivors (mean SDS -0.47, P = 0.008). TSH, fT4 and IGF-1 were normal in all survivors. Three of 20 adult females had low AMH levels and 23 of 42 adult males had low inhibin B levels.
  
  
  CONCLUSIONS
  Twelve years after cessation of treatment, NHL survivors did not develop adiposity, osteoporosis or thyroid disease. Male survivors may be at risk for infertility.
authors: Department of Pediatric Oncology/Hematology, Erasmus Medical Center, Rotterdam,The Netherlands .
authors: M
authors: M
authors: van Waas
authors: S J C M M
authors: SJ
authors: Neggers
authors: M L
authors: ML
authors: Te Winkel
authors: A
authors: A
authors: Beishuizen
authors: R
authors: R
authors: Pieters
authors: M M
authors: MM
authors: van den Heuvel-Eibrink
mesh_terms: D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001823:Body Composition; D001837:Body Weights and Measures; D015519:Bone Density; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004703:Endocrine System / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D006728:Hormones / Q000097:blood*; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000188:drug therapy*; D008297:Male; D011859:Radiography; D017741:Survivors; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D006728:Hormones