title: Clinical evaluation of a single daily dose of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch.
abstract: The objective of this retrospective study was to determine the efficacy of a single daily oral dose of phenylpropanolamine (PPA) in the treatment of urethral sphincter mechanism incompetence (USMI) in bitches. Nine bitches diagnosed with USMI were treated with a single daily dose [1.5 mg/kg body weight (BW)] of PPA for at least 1 month. Urethral pressure profiles (UPP) were performed in 7 dogs before treatment and repeated in 4 of them after treatment. Treatment with PPA resulted in long-term continence in 8/9 bitches. One dog did not respond to PPA and was treated surgically later. Recheck UPPs showed a significant increase in maximal urethral closure pressure in the 4 bitches after treatment with PPA compared to before treatment. In conclusion, long-term continence can be achieved in bitches affected with USMI after administration of a single daily dose of PPA (1.5 mg/kg BW).
authors: Department of Clinical Sciences (Companion Animals), Faculty of Veterinary Medicine, University of Liège, boulevard de Colonster, 20, B44, 4000 Liège, Belgium. Stephanie.Claeys@ulg.ac.be
authors: Stéphanie
authors: S
authors: Claeys
authors: Frederico
authors: F
authors: Rustichelli
authors: Stéphanie
authors: S
authors: Noël
authors: Annick
authors: A
authors: Hamaide
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004334:Drug Administration Schedule / Q000662:veterinary; D005260:Female; D010665:Phenylpropanolamine / Q000008:administration & dosage / Q000627:therapeutic use*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014549:Urinary Incontinence / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D000316:Adrenergic alpha-Agonists; D010665:Phenylpropanolamine