title: N-Glycans on secretory component: mediators of the interaction between secretory IgA and gram-positive commensals sustaining intestinal homeostasis.
abstract: Human beings live in symbiosis with billions of microorganisms colonizing mucosal surfaces. The understanding of the mechanisms underlying this fine-tuned intestinal balance has made significant processes during the last decades. We have recently demonstrated that the interaction of SIgA with Gram-positive bacteria is essentially based on Fab-independent, glycan-mediated recognition. Results obtained using mouse hybridoma- and colostrum-derived secretory IgA (SIgA) consistently show that N-glycans present on secretory component (SC) play a crucial role in the process. Natural coating may involve specific Gram-positive cell wall components, which may explain selective recognition at the molecular level. More widely, the existence of these complexes is involved in the modulation of intestinal epithelial cell (IEC) responses in vitro and the formation of intestinal biofilms. Thus, SIgA may act as one of the pillars in homeostatic maintenance of the microbiota in the gut, adding yet another facet to its multiple roles in the mucosal environment.
authors: The R&D Laboratory of the Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
authors: Amandine
authors: A
authors: Mathias
authors: Blaise
authors: B
authors: Corthésy
mesh_terms: D000818:Animals; D004847:Epithelial Cells / Q000378:metabolism / Q000382:microbiology; D006094:Gram-Positive Bacteria / Q000235:genetics / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000737:chemistry / Q000378:metabolism*; D007422:Intestines / Q000382:microbiology* / Q000502:physiology; D051379:Mice; D011134:Polysaccharides / Q000378:metabolism*; D011485:Protein Binding; D012635:Secretory Component / Q000737:chemistry / Q000378:metabolism*; D013559:Symbiosis
chemical_list: D007071:Immunoglobulin A, Secretory; D011134:Polysaccharides; D012635:Secretory Component