title: Acidic xylooligosaccharide preserves hepatic iron storage level in adult female rats fed a low-iron diet.
abstract: Iron deficiency anemia (IDA) is one of the most serious forms of malnutrition. This experiment was conducted to investigate whether acidic xylooligosaccharide (U-XOS), expected to have a high iron bioavailability, was useful in the prevention of iron deficiency. Experiment 1: Nineteen female Sprague-Dawley rats (20 wk old) were fed three different diets for 28 d; a U-XOS-supplemented low-iron diet (LI-X, n=7), a low-iron diet (LI, n=6), and a control diet (C, n=6). On day 28, the LI-X and LI groups showed iron deficiency without anemia. A significant difference in the total and unsaturated iron binding capacity, and serum transferrin saturation level was shown in the LI-X and LI groups, compared with the C group. However, the decrease of hepatic iron content of the LI-X group was suppressed compared with the LI group. Experiment 2: Eleven male Sprague-Dawley rats (7 wk old) were fed a U-XOS-supplemented diet (X, n=5) or a control diet (C, n=6) for 7 d. No significant difference in body weight gain or food intake was demonstrated between the two groups; the apparent iron absorption rate of the X group increased clearly compared with that of the C group. These results suggested that a U-XOS diet could preserve storage of hepatic iron in adult female rats fed a low-iron diet and could prevent IDA by promotion of dietary iron absorption, inhibition of iron excretion, and/or improvement of iron bioavailability.
authors: Laboratory of Nutrition Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Shimogamo, Kyoto, Japan. yukicoba@kpu.ac.jp
authors: Yukiko
authors: Y
authors: Kobayashi
authors: Takayuki
authors: T
authors: Ohbuchi
authors: Tomo
authors: T
authors: Fukuda
authors: Etsuko
authors: E
authors: Wakasugi
authors: Risa
authors: R
authors: Yasui
authors: Mai
authors: M
authors: Hamada
authors: Meiko
authors: M
authors: Yokoyama
authors: Masashi
authors: M
authors: Kuwahata
authors: Yasuhiro
authors: Y
authors: Kido
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000378:metabolism / Q000517:prevention & control*; D000818:Animals; D001682:Biological Availability; D004032:Diet; D004040:Dietary Carbohydrates / Q000494:pharmacology / Q000627:therapeutic use*; D019587:Dietary Supplements; D005260:Female; D005965:Glucuronates / Q000494:pharmacology / Q000627:therapeutic use*; D007501:Iron / Q000008:administration & dosage / Q000378:metabolism*; D000090463:Iron Deficiencies; D019266:Iron, Dietary / Q000008:administration & dosage; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D009844:Oligosaccharides / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014168:Transferrin / Q000378:metabolism
chemical_list: D004040:Dietary Carbohydrates; D005965:Glucuronates; D019266:Iron, Dietary; D009844:Oligosaccharides; D014168:Transferrin; C570991:xylooligosaccharide; D007501:Iron