title: Quantification of hydroxyprolyl-glycine (Hyp-Gly) in human blood after ingestion of collagen hydrolysate.
abstract: Plasma levels of prolyl-hydroxyproline (Pro-Hyp) and hydroxyprolyl-glycine (Hyp-Gly) in healthy volunteers (n=5) after ingestion of collagen hydrolysate were estimated by liquid chromatography-tandem mass spectrometry. The ratio of Hyp-Gly to Pro-Hyp was distributed in the range of 0.063-0.221. This is a first report for quantification of food-derived Hyp-Gly in human plasma.
authors: Nitta Gelatin Inc., Peptide Division, 2-22 Futamata, Yao, Osaka 581-0024, Japan. fu-sugihara@nitta-gelatin.co.jp
authors: Fumihito
authors: F
authors: Sugihara
authors: Naoki
authors: N
authors: Inoue
authors: Masanori
authors: M
authors: Kuwamori
authors: Makoto
authors: M
authors: Taniguchi
mesh_terms: D000328:Adult; D003094:Collagen / Q000008:administration & dosage* / Q000378:metabolism; D004151:Dipeptides / Q000097:blood*; D004435:Eating; D006801:Humans; D006868:Hydrolysis; D008297:Male; D053719:Tandem Mass Spectrometry
chemical_list: D004151:Dipeptides; C575137:hydroxyprolyl-glycine; C533879:prolyl-4-hydroxyproline; D003094:Collagen