title: DNA repair gene XPD and XRCC1 polymorphisms and the risk of febrile neutropenia and mucositis in children with leukemia and lymphoma.
abstract: The aim of the study is to investigate association between DNA repair gene XPD and XRCC1 polymorphisms and febrile neutropenia (FN) and mucositis. The study population consisted of 29 children with Burkitt lymphoma and 61 children with acute lymphoblastic leukemia. Analysis revealed that XRCC1194Trp allele showed a protective effect against longer FN and mucositis. There was also statistically increased risk for severe mucositis in patients with XRCC1Arg399Gln polymorphism. There are no studies that have examined this relationship before. Further studies with larger cohorts are needed to clarify the association.
authors: Department of Pediatric Hematology-Oncology, Cerrahpasa Medical Faculty, Istanbul, Turkey. gnozdemir@hotmail.com
authors: Nihal
authors: N
authors: Ozdemir
authors: Tiraje
authors: T
authors: Celkan
authors: Safa
authors: S
authors: Barış
authors: Bahadır
authors: B
authors: Batar
authors: Mehmet
authors: M
authors: Güven
mesh_terms: D000293:Adolescent; D002051:Burkitt Lymphoma / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005334:Fever / Q000209:etiology / Q000235:genetics; D006801:Humans; D007223:Infant; D008297:Male; D052016:Mucositis / Q000209:etiology / Q000235:genetics*; D009503:Neutropenia / Q000209:etiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D012306:Risk; D000076105:X-ray Repair Cross Complementing Protein 1; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human; D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human