title: Pathogenicity of Pasteurella pneumotropica in immunodeficient NOD/ShiJic-scid/Jcl and immunocompetent Crlj:CD1 (ICR) mice.
abstract: Pasteurella pneumotropica is an opportunistic pathogen in rodents. Natural infection in immunodeficient animals suggests that immunodeficiency is a major factor in P. pneumotropica pathogenesis. To understand this process, we performed clinical, pathological and bacteriological studies of immunodeficient NOD/ShiJic-scid/Jcl and immunocompetent Crlj:CD1 (ICR) mice experimentally infected with P. pneumotropica ATCC 35149. From 14 days postinoculation, some of P. pneumotropica-infected NOD/ShiJic-scid/Jcl mice developed clinical signs of weight loss. Three of 10 P. pneumotropica-infected NOD/ShiJic-scid/Jcl mice developed clinical signs of depression, ruffled coat, and weight loss and died at 27, 34, and 59 days postinoculation. At 35 days postinoculation, almost all P. pneumotropica-infected NOD/ShiJic-scid/Jcl mice had lung abscesses. The bacteria were isolated from the upper and lower respiratory tracts, including the lungs, and blood. In contrast, P. pneumotropica-infected ICR mice exhibited no clinical signs or lesions. The bacteria were isolated from the upper, but not the lower respiratory tracts. We developed an animal model for understanding host interactions with P. pneumotropica.
authors: Animal Research Center, Tokyo Medical University, Shinjuku, Tokyo 160-8402, Japan.
authors: Eiichi
authors: E
authors: Kawamoto
authors: Hiraku
authors: H
authors: Sasaki
authors: Emi
authors: E
authors: Okiyama
authors: Takao
authors: T
authors: Kanai
authors: Hidehiro
authors: H
authors: Ueshiba
authors: Naoko
authors: N
authors: Ohnishi
authors: Takuo
authors: T
authors: Sawada
authors: Nobuhito
authors: N
authors: Hayashimoto
authors: Akira
authors: A
authors: Takakura
authors: Toshio
authors: T
authors: Itoh
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D054884:Host-Pathogen Interactions; D007121:Immunocompetence; D016867:Immunocompromised Host; D051379:Mice; D008813:Mice, Inbred ICR / Q000276:immunology* / Q000382:microbiology*; D016688:Mice, Inbred NOD / Q000276:immunology* / Q000382:microbiology*; D016513:Mice, SCID / Q000276:immunology* / Q000382:microbiology*; D010326:Pasteurella Infections / Q000276:immunology* / Q000382:microbiology* / Q000473:pathology / Q000503:physiopathology; D044142:Pasteurella pneumotropica / Q000302:isolation & purification / Q000472:pathogenicity*; D012137:Respiratory System / Q000382:microbiology / Q000473:pathology; D014774:Virulence