title: First total synthesis of (+)-Vedelianin, a potent antiproliferative agent.
abstract: The total synthesis of (+)-vedelianin has been accomplished in 18 steps from vanillin. Preparation of a key intermediate in nonracemic form through a Shi epoxidation has allowed determination of the absolute stereochemistry of the natural product as the (2S, 3R, 4aR, 9aR)-isomer.
authors: Department of Chemistry, The University of Iowa 52242-1294.
authors: Joseph J
authors: JJ
authors: Topczewski
authors: David F
authors: DF
authors: Wiemer