title: Polysaccharides from Capsosiphon fulvescens stimulate the growth of gastrointestinal cells.
abstract: Capsosiphon fulvescens is a green alga that is abundant along the southwest coast of South Korea. Although it is consumed for its purported health-enhancing properties, particularly as a treatment for stomach disorders and hangovers, the health effects of dietary C. fulvescens remain unclear. Polysaccharides extracted from C. fulvescens (Cf-PS) are investigated for their effects on the proliferation of rat small intestinal epithelial IEC-6 cells. Cf-PS stimulated IEC-6 cell proliferation in a dose-dependent manner. Further, Cf-PS treatment induced the translocation of β-catenin, an effector of the Wnt signaling pathway, from the cytosol to the nucleus and increased the expression of cyclinD1 and c-myc. Cf-PS also induced ERK1/2 phosphorylation, which is activated by mitogenic and proliferative stimuli such as growth factors, but the phosphorylation of JNK and p38 was not enhanced. Therefore, this chapter discusses the effect of Cf-PS on the growth of gastrointestinal cells.
authors: College of Fisheries Science, Pukyong National University, Busan, Republic of Korea.
authors: Hye-Jung
authors: HJ
authors: Hwang
authors: In-Hye
authors: IH
authors: Kim
authors: Taek-Jeong
authors: TJ
authors: Nam
mesh_terms: D000818:Animals; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects*; D000460:Chlorophyta / Q000737:chemistry*; D004847:Epithelial Cells / Q000166:cytology* / Q000187:drug effects* / Q000502:physiology; D005786:Gene Expression Regulation / Q000187:drug effects; D007413:Intestinal Mucosa / Q000166:cytology*; D051381:Rats; D015398:Signal Transduction / Q000187:drug effects; D051153:Wnt Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D051153:Wnt Proteins