title: [Effects of proton pump inhibitors in asthmatics with gastroesophageal reflux disease].
abstract: OBJECTIVE
  Gastroesophageal reflux disease (GERD) is common in asthma patients. Proton pump inhibitor (PPI) therapy improves symptoms of asthma in some patients. The objective of this study was to investigate endoscopic findings of GERD in asthma patients and to assess the effect of gastric acid suppression with the PPIs on symptom improvement and pulmonary function.
  
  
  METHODS
  From 105 consecutive patients with GERD symptoms during follow up for asthma, 45 patients were enrolled. Patients enrolled to this study were asked about GERD symptoms before and after treating with PPI. Endoscopic findings were described according to Los Angeles classification. The improvement of asthma symptoms and follow-up pulmonary function test were investigated after administration of PPIs.
  
  
  RESULTS
  Esophageal symptoms such as heartburn and acid reflux were present in 25 patients (55.6%), and patients without esophageal symptoms were 20 (44.4%). The degree of endoscopic abnormality was not significantly different between groups with or without esophageal symptoms. The improvement of symptoms was seen in 44 patients (97.8%) except 1 patient after administration of PPIs. The number of patients classified to the low-dose group was 7 patients (15.6%) and that of patients classified to the standard-dose group was 38 patients (84.4%). The follow-up pulmonary function test, peak expiratory flow rate (L/sec) was improved in 3 patients (3 of 7, 42.9%) of the low-dose group, and in 24 patients (24 of 38, 63.2%) of the standard-dose group. The improvement of ventilatory function was not significantly different according to dose of PPIs.
  
  
  CONCLUSIONS
  Treatment with PPIs is expected to improve subjective symptoms and ventilatory function in asthma patients.
authors: Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
authors: Yun Bin
authors: YB
authors: Lee
authors: Joo Hyun
authors: JH
authors: Lim
authors: Yoon Jin
authors: YJ
authors: Choi
authors: Ji Yeon
authors: JY
authors: Kim
authors: Jun Hyuk
authors: JH
authors: Son
authors: Sun Mi
authors: SM
authors: Choi
authors: Hyun Jin
authors: HJ
authors: Jo
authors: Cheol Min
authors: CM
authors: Shin
authors: Sang Hyup
authors: SH
authors: Lee
authors: Young Soo
authors: YS
authors: Park
authors: Jin Hyeok
authors: JH
authors: Hwang
authors: Jin Wook
authors: JW
authors: Kim
authors: Sook Hyang
authors: SH
authors: Jeong
authors: Nayoung
authors: N
authors: Kim
authors: Dong Ho
authors: DH
authors: Lee
authors: Hyun Chae
authors: HC
authors: Jung
authors: In Sung
authors: IS
authors: Song
mesh_terms: D000318:Adrenergic beta-Agonists / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D001249:Asthma / Q000150:complications* / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D005764:Gastroesophageal Reflux / Q000150:complications / Q000188:drug therapy*; D005773:Gastroscopy; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010366:Peak Expiratory Flow Rate; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000318:Adrenergic beta-Agonists; D005938:Glucocorticoids; D054328:Proton Pump Inhibitors