title: Synthesis of locked pyranosyl nucleic acid (LpNA).
abstract: A new locked pyranosyl nucleoside was synthesized by phenylsulfinyl-assisted chemistry. The novel building block was inserted into oligonucleotides and provides new insight on conformational restricted pyranosyl nucleosides on duplex formation.
authors: Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark.
authors: Niels
authors: N
authors: Bomholt
authors: Per T
authors: PT
authors: Jørgensen
authors: Erik B
authors: EB
authors: Pedersen
mesh_terms: D001483:Base Sequence; D008958:Models, Molecular; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D010126:Ozone; D044367:Phase Transition; D011714:Pyrans / Q000737:chemistry*; D044366:Transition Temperature
chemical_list: D009841:Oligonucleotides; D011714:Pyrans; C477371:locked nucleic acid; D010126:Ozone