title: Coinfection with Cryptococcus gattii and Mycobacterium tuberculosis in an otherwise healthy 18-year-old woman.
abstract: A case of Cryptococcus gattii (pulmonary and central nervous system) and Mycobacterium tuberculosis (pulmonary) coinfection in an otherwise healthy young woman is reported. The patient presented with a two-month history of dry cough. She had an unremarkable medical history. Both tuberculosis and cryptococcosis were diagnosed following bronchoscopy, and a subsequent lumbar puncture revealed C gattii in the cerebrospinal fluid. There is evidence that both M tuberculosis and C gattii may have suppressive effects on the host immune system. This suggests a mechanism by which an otherwise healthy individual developed these two infections.
authors: Division of Respiratory Medicine, University of Bristish Columbia, Vancouver, British Columbia. lindsayvantongeren@gmail.com
authors: Lindsay
authors: L
authors: Van Tongeren
authors: Tawimas
authors: T
authors: Shaipanich
authors: John A
authors: JA
authors: Fleetham
mesh_terms: D000293:Adolescent; D000935:Antifungal Agents / Q000008:administration & dosage; D000995:Antitubercular Agents / Q000008:administration & dosage; D001999:Bronchoscopy / Q000379:methods; D002490:Central Nervous System / Q000382:microbiology / Q000473:pathology; D060085:Coinfection; D003453:Cryptococcosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology; D056285:Cryptococcus gattii / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity; D005260:Female; D006801:Humans; D007107:Immune System / Q000382:microbiology*; D008168:Lung / Q000382:microbiology / Q000473:pathology; D056265:Microbial Interactions; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity; D013129:Spinal Puncture / Q000379:methods; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D000995:Antitubercular Agents