title: A case of renal oxalosis in a 3-month-old cat raised under controlled conditions.
abstract: The kidneys of a 3-month-old female cat were examined. The cat which had been raised under controlled conditions with no history of any poisoning showed progressive weight loss with increases in blood BUN and creatinine concentrations. At necropsy, both kidneys were firm in consistency with formation of focal scars. Histopathologically, widespread deposition of crystals was observed in the renal tubules (in both dilated lumina and degenerative epithelia) accompanying mild interstitial fibrosis with lymphocyte infiltration. The crystals were colorless or basophilic on the hematoxilin and eosin-stained section and could be visualized with polarized light as doubly fractile crystals. The crystals were identified as calcium oxalate crystals by histochemical examinations using von Kossa stain and alizarin red S stain under different conditions and by ultrastructural examination. Judging from the above-mentioned findings, the present renal lesion detected in an infant cat was diagnosed as renal oxalosis which was suspected to be hereditary in nature.
authors: Nippon Institute for Biological Science, Ome, Tokyo 198–0024, Japan. takayuki.s@nibs.or.jp
authors: Takayuki
authors: T
authors: Suzuki
authors: Koji
authors: K
authors: Uetsuka
authors: Kunio
authors: K
authors: Doi
authors: Tetsuo
authors: T
authors: Nunoya
mesh_terms: D000818:Animals; D002129:Calcium Oxalate; D002371:Cat Diseases / Q000235:genetics / Q000473:pathology*; D002415:Cats; D005260:Female; D020022:Genetic Predisposition to Disease; D007669:Kidney Calculi / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D007684:Kidney Tubules / Q000473:pathology
chemical_list: D002129:Calcium Oxalate