title: Persistence: mechanisms for triggering and enhancing phenotypic variability.
abstract: When microorganisms are exposed to lethal agents, the initial exponential decay in survival is typically followed by a slower decrease. This tailing of the survival curve is due to persister cells that have differentiated into phenotypes with reduced sensitivity to the lethal agent. We review the environmental factors that have been shown to trigger such differentiation processes, as well as the network motifs that enable the co-existence of persistent and nonpersistent cells within genetically uniform populations. Threshold amplification of noise and bi-stability from positive feedback emerge as key motifs underlying persistence.
authors: Racah Institute of Physics and Center for Nanoscience and Nanotechnology, Hebrew University, Edmond J. Safra Campus, Jerusalem 91904, Israel. nathalieqb@phys.huji.ac.il
authors: N Q
authors: NQ
authors: Balaban
mesh_terms: D000222:Adaptation, Physiological; D000900:Anti-Bacterial Agents / Q000378:metabolism; D000992:Antitoxins / Q000378:metabolism*; D001419:Bacteria / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D001427:Bacterial Toxins / Q000037:antagonists & inhibitors*; D002455:Cell Division; D002470:Cell Survival / Q000187:drug effects; D024881:Drug Resistance, Bacterial / Q000187:drug effects / Q000235:genetics*; D015964:Gene Expression Regulation, Bacterial; D014644:Genetic Variation; D008954:Models, Biological; D010641:Phenotype
chemical_list: D000900:Anti-Bacterial Agents; D000992:Antitoxins; D001427:Bacterial Toxins