title: Multiple depositions of Ag nanoparticles on chemically modified agarose films for surface-enhanced Raman spectroscopy.
abstract: A facile and cost-effective approach for the preparation of a surface-enhanced Raman spectroscopy (SERS) substrate through constructing silver nanoparticle/3-aminopropyltriethoxysilane/agarose films (Ag NPs/APTES/Agar film) on various solid supports is described. The SERS performance of the substrate was systematically investigated, revealing a maximum SERS intensity with four layers of the Ag NP deposition. The enhancement factor of the developed substrate was calculated as 1.5 × 10(7) using rhodamine 6G (R6G) as the probe molecule, and the reproducibility of the SERS signals was established. A high throughput screening platform was designed, manufactured and implemented which utilised the ability to cast agarose to assemble arrays. Quantitative analysis of 4-aminobenzoic acid (4-ABA) and 4-aminothiophenol (4-ATP) was achieved over a ∼0.5 nM-0.1 μM range.
authors: Key Laboratory for Advanced Materials & Department of Chemistry, East China University of Science 4 and Technology, Shanghai 200237, P.R. China.
authors: Wen-Lei
authors: WL
authors: Zhai
authors: Da-Wei
authors: DW
authors: Li
authors: Lu-Lu
authors: LL
authors: Qu
authors: John S
authors: JS
authors: Fossey
authors: Yi-Tao
authors: YT
authors: Long
mesh_terms: D010129:4-Aminobenzoic Acid / Q000737:chemistry; D000814:Aniline Compounds / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D012235:Rhodamines / Q000737:chemistry; D012685:Sepharose / Q000737:chemistry; D012834:Silver / Q000737:chemistry*; D013059:Spectrum Analysis, Raman; D013438:Sulfhydryl Compounds
chemical_list: D000814:Aniline Compounds; D012235:Rhodamines; D013438:Sulfhydryl Compounds; C026188:rhodamine 6G; D012834:Silver; C064316:4-aminothiophenol; D012685:Sepharose; D010129:4-Aminobenzoic Acid