title: t(X;14)(p11.4;q32.33) is recurrent in marginal zone lymphoma and up-regulates GPR34.
abstract: Genetic events underlying pathogenesis of nodal and extranodal marginal zone lymphoma are not completely understood. We report here a novel t(X;14)(p11.4;q32.33) identified in 4 lymphoma cases: 2 with a mucosa-associated lymphoid tissue lymphoma, one with a nodal marginal zone lymphoma and one with gastric diffuse large B-cell lymphoma. In all cases, lymphoma evolved from a previous auto-immune disorder. Fluorescence in situ hybridization and molecular studies showed that t(X;14), which is mediated by immunoglobulin heavy chain locus, targets the GPR34 gene at Xp11.4. Upregulation of GPR34 mRNA and aberrant expression of GPR34 protein has been demonstrated in 3 presented cases by quantitative real-time polymerase chain reaction and immunohistochemistry, respectively. GPR34 belongs to the largest family of cell surface molecules involved in signal transmission that play important roles in many physiological and pathological processes, including tumorigenesis. Although functional consequences of t(X;14) have not been identified, our studies suggest that up-regulated GPR34 activate neither nuclear factor-κB nor ELK-related tyrosine kinase.
authors: Center for Human Genetics, KU Leuven, Leuven, Belgium.
authors: Mathijs
authors: M
authors: Baens
authors: Julio
authors: J
authors: Finalet Ferreiro
authors: Thomas
authors: T
authors: Tousseyn
authors: Helena
authors: H
authors: Urbankova
authors: Lucienne
authors: L
authors: Michaux
authors: Laurence
authors: L
authors: de Leval
authors: Daan
authors: D
authors: Dierickx
authors: Pascal
authors: P
authors: Wolter
authors: Xavier
authors: X
authors: Sagaert
authors: Peter
authors: P
authors: Vandenberghe
authors: Christiane
authors: C
authors: De Wolf-Peeters
authors: Iwona
authors: I
authors: Wlodarska
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D005260:Female; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics* / Q000378:metabolism; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics / Q000378:metabolism; D008297:Male; D049312:Receptors, Lysophospholipid / Q000235:genetics / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: C118065:G-protein-coupled receptor 34; D049312:Receptors, Lysophospholipid