title: [Non-invasive drug delivery system with the claudin binder].
abstract: The intercellular spaces between adjacent epithelial cells are sealed by tight junctions (TJs). Modulation of TJ-seal is a potent strategy for drug absorption. Claudin is a key structural and functional component of TJ-seal. Claudin comprises a tetra-transmembrane protein family consisting of more than 20 members, whose expression profiles and barrier-function differ among tissues. For instance, claudin-1 plays roles in the epidermal and mucosal barriers, and claudin-4 regulates the mucosal barrier. Claudin forms homo- and hetero-type TJ strands. Properties of TJ-seal are determined by combination of the claudin family members. Some claudin strands work as size-selective or charge-selective paracellular routes for solutes. Thus, claudin modulators will make it possible to deliver drugs in a solute- and tissue-specific manner. The C-terminal fragment of the Clostridium perfringens enterotoxin (C-CPE) is the most characterized claudin modulator. In this review, we describe potency of claudin-targeting mucosal absorption, and we mentioned development of a novel claudin modulator using C-CPE as a prototype.
authors: Department of Bio-Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan. azusa@phs.osaka-u.ac.jp
authors: Azusa
authors: A
authors: Takahashi
authors: Masuo
authors: M
authors: Kondoh
authors: Kiyohito
authors: K
authors: Yagi
mesh_terms: D057167:Claudins / Q000737:chemistry / Q000502:physiology*; D016503:Drug Delivery Systems; D015195:Drug Design; D004768:Enterotoxins / Q000737:chemistry / Q000494:pharmacology; D058990:Molecular Targeted Therapy; D009092:Mucous Membrane / Q000378:metabolism; D019108:Tight Junctions / Q000737:chemistry / Q000502:physiology
chemical_list: D057167:Claudins; D004768:Enterotoxins; C035598:enterotoxin, Clostridium