title: The burden of cancer risk in Canada's indigenous population: a comparative study of known risks in a Canadian region.
abstract: BACKGROUND
  Canadian First Nations, the largest of the Aboriginal groups in Canada, have had lower cancer incidence and mortality rates than non-Aboriginal populations in the past. This pattern is changing with increased life expectancy, a growing population, and a poor social environment that influences risk behaviors, metabolic conditions, and disparities in screening uptake. These factors alone do not fully explain differences in cancer risk between populations, as genetic susceptibility and environmental factors also have significant influence. However, genetics and environment are difficult to modify. This study compared modifiable behavioral risk factors and metabolic-associated conditions for men and women, and cancer screening practices of women, between First Nations living on-reserve and a non-First Nations Manitoba rural population (Canada).
  
  
  METHODS
  The study used data from the Canadian Community Health Survey and the Manitoba First Nations Regional Longitudinal Health Survey to examine smoking, binge drinking, metabolic conditions, physical activity, fruit/vegetable consumption, and cancer-screening practices.
  
  
  RESULTS
  First Nations on-reserve had significantly higher rates of smoking (P < 0.001), binge drinking (P < 0.001), obesity (P < 0.001) and diabetes (P < 0.001), and less leisure-time physical activity (P = 0.029), and consumption of fruits and vegetables (P < 0.001). Sex differences were also apparent. In addition, First Nations women reported significantly less uptake of mammography screening (P < 0.001) but similar rates for cervical cancer screening.
  
  
  CONCLUSIONS
  Based on the findings of this retrospective study, the future cancer burden is expected to be high in the First Nations on-reserve population. Interventions, utilizing existing and new health and social authorities, and long-term institutional partnerships, are required to combat cancer risk disparities, while governments address economic disparities.
authors: Faculty of Medicine, Department of Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
authors: Brenda
authors: B
authors: Elias
authors: Erich V
authors: EV
authors: Kliewer
authors: Madelyn
authors: M
authors: Hall
authors: Alain A
authors: AA
authors: Demers
authors: Donna
authors: D
authors: Turner
authors: Patricia
authors: P
authors: Martens
authors: Say P
authors: SP
authors: Hong
authors: Lyna
authors: L
authors: Hart
authors: Caroline
authors: C
authors: Chartrand
authors: Garry
authors: G
authors: Munro