title: Evidence of prophylaxis treatment in adult haemophiliacs. Need of this treatment strategy?
abstract: In contrast to children with haemophilia the scientific evidence of prophylaxis treatment in adults is not yet proven. Existing studies are of observational character and mostly retrospectively designed. Therefore, opinion leaders in this field postulate prospectively designed, randomized, controlled and multicentric studies to set up urgently needed guidelines. Evidence according to the Canadian task force ranking is assessed as level III with a recommendation grade C by the authors. The recognition of benefits of health care providers in accordance with the German Federal Joint Committee generally demands a Grade-Ia to Ib evidence. As long as the actual evidence of prophylaxis in adult haemophiliacs does not meet the postulated criteria of the German Federal Joint Committee, prophylactic replacement therapy of the individual case has to be well documented and reasonably explained.
authors: MDK Baden-Württemberg, Ahornweg 2, 77933 Lahr. karl-heinz.beck@mdkbw.de
authors: K-H
authors: KH
authors: Beck
authors: J
authors: J
authors: Holzschuh
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D015897:Comorbidity; D019317:Evidence-Based Medicine; D005260:Female; D006467:Hemophilia A / Q000453:epidemiology* / Q000451:nursing / Q000517:prevention & control*; D006801:Humans; D007592:Joint Diseases / Q000453:epidemiology* / Q000451:nursing / Q000517:prevention & control*; D008297:Male; D015995:Prevalence; D011788:Quality of Life; D016896:Treatment Outcome; D055815:Young Adult