title: Serum uric acid levels and the clinical characteristics of depression.
abstract: OBJECTIVE
  This study was designed to investigate the correlation between serum uric acid (UA) levels and the clinical characteristics of depression.
  
  
  METHODS
  The serum UA levels were measured in 124 patients with depression, 660 patients with different types of other mental disorders (OMD) and 42 healthy subjects. Clinical characteristics of depression and OMD were also investigated.
  
  
  RESULTS
  Depressive patients (271.97 ± 77.50 μmol/L) had significantly lower UA levels than those with delirium, dementia, amnesia and other cognitive disorders (339.95 ± 141.74 μmol/L, P=0.004), substances related disorders (359.61 ± 125.02 μmol/L, P=0.022), schizophrenia (341.03 ± 106.84 μmol/L, P=0.000), schizoaffective disorder (336.78 ± 155.49 μmol/L, P=0.024), bipolar disorder (323.04 ± 108.70 μmol/L, P=0.008) and the healthy control group (315.76 ± 87.50 μmol/L, P=0.012). We also found that the UA levels of depressive patients normalised after a five week treatment with antidepressants.
  
  
  CONCLUSIONS
  Our data suggested that a lowered UA level is another characteristic of depression.
authors: Department of Psychiatry, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, 510630, Guangdong Province, People's Republic of China. wenshl@mail.sysu.edu.cn
authors: Shenglin
authors: S
authors: Wen
authors: Minfeng
authors: M
authors: Cheng
authors: Houliang
authors: H
authors: Wang
authors: Jihui
authors: J
authors: Yue
authors: Hong
authors: H
authors: Wang
authors: Guanying
authors: G
authors: Li
authors: Liangrong
authors: L
authors: Zheng
authors: Zhiyong
authors: Z
authors: Zhong
authors: Fuhua
authors: F
authors: Peng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003863:Depression / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000097:blood; D008875:Middle Aged; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid