title: Langerhans cells histiocytosis with vulvar involvement and responding to thalidomide therapy--case report.
abstract: Langerhans cell histiocytosis is a member of a group of rare histiocytic syndromes and is characterized for the proliferation of histiocytes called Langerhans'cells. Its manifestations vary from a solitary injury to systemic involvement, and vulvar lesions are uncommon. We describe a refractory case of cutaneous limited disease in a 57-year-old woman. She presented with a 6-year history of an erythematous papular eruption of the scalp, face, vulva, trunk and axillae. The diagnosis is difficult and in this case it was confirmed through immunohistochemical study and clinical improvement was achieved with thalidomide.
authors: Hospital das Clínicas, Universidade Federal de Goiás, Goiânia, Brasil. lanabezerra@hotmail.com
authors: Lana Bezerra
authors: LB
authors: Fernandes
authors: Jackeline Gomes
authors: JG
authors: Guerra
authors: Maurício Barcelos
authors: MB
authors: Costa
authors: Isadora Guimarães
authors: IG
authors: Paiva
authors: Fernanda Paglia
authors: FP
authors: Duran
authors: Diogo Neves
authors: DN
authors: Jacó
mesh_terms: D005148:Facial Dermatoses / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008875:Middle Aged; D012536:Scalp Dermatoses / Q000188:drug therapy / Q000473:pathology; D012871:Skin Diseases / Q000188:drug therapy* / Q000473:pathology; D013792:Thalidomide / Q000627:therapeutic use*; D014845:Vulvar Diseases / Q000188:drug therapy* / Q000473:pathology
chemical_list: D007166:Immunosuppressive Agents; D013792:Thalidomide