title: Macroglossia and generalized edema not due to hypothyroidism.
abstract: We present a 69-year-old male patient with the macroglossia, dysphagia and generalized edema. He was seen previously by other physicians and diagnosed as hypothyroidism. With thyroid stimulating hormone in normal range, tongue biopsy revealed primary systemic amyloidosis. Amyloidosis is the most common cause of macroglossia. Primary systemic amyloidosis should be suspected when laboratory does not support hypothyroidism especially if the enlarged tongue is firm and additional findings are present.
authors: Otolaryngology Department, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. alimoglu2001@gmail.com
authors: Yalcin
authors: Y
authors: Alimoglu
authors: Fadime Sevgi
authors: FS
authors: Sacli
authors: Sibel
authors: S
authors: Erdamar
mesh_terms: D000368:Aged; D000686:Amyloidosis / Q000150:complications* / Q000175:diagnosis / Q000473:pathology*; D001706:Biopsy; D003680:Deglutition Disorders / Q000209:etiology; D004487:Edema / Q000209:etiology*; D006801:Humans; D007037:Hypothyroidism / Q000175:diagnosis; D008260:Macroglossia / Q000209:etiology*; D008297:Male; D013972:Thyrotropin / Q000097:blood
chemical_list: D013972:Thyrotropin