title: Flavivirus cell entry and membrane fusion.
abstract: Flaviviruses, such as dengue virus and West Nile virus, are enveloped viruses that infect cells through receptor-mediated endocytosis and fusion from within acidic endosomes. The cell entry process of flaviviruses is mediated by the viral E glycoprotein. This short review will address recent advances in the understanding of flavivirus cell entry with specific emphasis on the recent study of Zaitseva and coworkers, indicating that anionic lipids might play a crucial role in the fusion process of dengue virus [1].
authors: Department of Medical Microbiology, Molecular Virology Section, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
authors: Jolanda M
authors: JM
authors: Smit
authors: Department of Medical Microbiology, Molecular Virology Section, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
authors: Bastiaan
authors: B
authors: Moesker
authors: Department of Medical Microbiology, Molecular Virology Section, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
authors: Izabela
authors: I
authors: Rodenhuis-Zybert
authors: Department of Medical Microbiology, Molecular Virology Section, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
authors: Jan
authors: J
authors: Wilschut
mesh_terms: D002462:Cell Membrane / Q000378:metabolism / Q000821:virology; D003715:Dengue / Q000378:metabolism / Q000821:virology; D003716:Dengue Virus / Q000378:metabolism*; D004705:Endocytosis; D011992:Endosomes / Q000737:chemistry / Q000378:metabolism / Q000821:virology; D006801:Humans; D008561:Membrane Fusion; D008563:Membrane Lipids / Q000378:metabolism*; D014759:Viral Envelope Proteins / Q000378:metabolism; D053586:Virus Internalization; D014901:West Nile Fever / Q000378:metabolism / Q000821:virology; D014902:West Nile virus / Q000378:metabolism*
chemical_list: D008563:Membrane Lipids; D014759:Viral Envelope Proteins