title: Small molecule library synthesis using segmented flow.
abstract: Flow chemistry has gained considerable recognition as a simple, efficient, and safe technology for the synthesis of many types of organic and inorganic molecules ranging in scope from large complex natural products to silicon nanoparticles. In this paper we describe a method that adapts flow chemistry to the synthesis of libraries of compounds using a fluorous immiscible solvent as a spacer between reactions. The methodology was validated in the synthesis of two small heterocycle containing libraries. The reactions were performed on a 0.2 mmol scale, enabling tens of milligrams of material to be generated in a single 200 mL reaction plug. The methodology allowed library synthesis in half the time of conventional microwave synthesis while maintaining similar yields. The ability to perform multiple, potentially unrelated reactions in a single run is ideal for making small quantities of many different compounds quickly and efficiently.
authors: Medinical Chemistry Technologies, Abbott Laboratories, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA. Christina.m.thompson@abbott.com
authors: Christina M
authors: CM
authors: Thompson
authors: Jennifer L
authors: JL
authors: Poole
authors: Jeffrey L
authors: JL
authors: Cross
authors: Irini
authors: I
authors: Akritopoulou-Zanze
authors: Stevan W
authors: SW
authors: Djuric
mesh_terms: D002625:Chemistry, Organic / Q000295:instrumentation / Q000379:methods*; D020650:Combinatorial Chemistry Techniques / Q000295:instrumentation / Q000379:methods*; D008872:Microwaves; D015394:Molecular Structure; D054852:Small Molecule Libraries / Q000138:chemical synthesis*; D012997:Solvents / Q000737:chemistry
chemical_list: D054852:Small Molecule Libraries; D012997:Solvents