title: Efficacy of passive uterine straightening during intrauterine insemination on pregnancy rates and ease of technique.
abstract: OBJECTIVE
  The aim of the present study was to evaluate the efficacy of passive uterine straightening during intrauterine insemination (IUI).
  
  
  METHODS
  A randomized controlled trial was conducted at Zeynep Kamil Maternity and Pediatric Research and Training Hospital. Participants were 460 women with unexplained infertility. Interventions were IUI by passive straightening of the uterus by means of bladder filling, or IUI performed with an empty bladder. Main outcome measures included pregnancy rate and difficulty of IUI.
  
  
  RESULTS
  Four hundred and sixty couples were allocated: 230 couples were allocated to the full bladder group, and 230 couples were allocated to the empty bladder group (control). The pregnancy rate was higher in the full bladder group than in the empty bladder (control) group (P=0.03, 13.5% vs 7.4%; relative risk [RR] 1.95 for pregnant patients; 95% confidence intervals [CI] 1.048-3.637). The risk of undergoing difficult IUI was higher in the empty bladder group than the full bladder group (P<0.001; 10.0% vs 37.8%, RR 0.18 for difficulty IUI; 95% CI 0.11-0.30). The clinical pregnancy rate was also higher in the group of patients who had easy IUI than in the group of patients who had difficult IUI (P<0.05, 12.7% [42/331] vs 5.5% [6/110]); RR 2.51 for pregnancy; 95% CI 1.04-6.09).
  
  
  CONCLUSIONS
  Passive straightening of the uterus makes the procedure less difficult and improves the clinical pregnancy rate.
authors: Department of Obstetrics and Gynecology, Zeynep Kamil Maternity and Pediatric Research and Training Hospital, Istanbul, Turkey. sayas55@hotmail.com
authors: Selcuk
authors: S
authors: Ayas
authors: Ayse
authors: A
authors: Gurbuz
authors: Reyhan
authors: R
authors: Ayaz
authors: Mehmet Reşit
authors: MR
authors: Asoglu
authors: Selcuk
authors: S
authors: Selcuk
authors: Akif
authors: A
authors: Alkan
authors: Sadiye
authors: S
authors: Eren
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D007315:Insemination, Artificial / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D016896:Treatment Outcome; D001743:Urinary Bladder; D014599:Uterus