title: [Molecular mechanism of imatinib-induced thrombocytopenia in treatment of patients with CML].
abstract: Imatinib mesylate has been commonly used in the treatment of patients with chronic myeloid leukemia (CML). However, a significant number of CML patients treated with imatinib developed thrombocytopenia. Platelet-derived growth factor (PDGF)/platelet-derived growth factor receptor (PDGFR) plays a significant role in the regulation of thrombopoiesis. It is suggested that imatinib may block the PDGF/PDGFR and PI3-K/Akt pathway, then inducing the apoptosis of megakaryocytes and developing thrombocytopenia in these patients. In this review, the potential molecular mechanism of imatinib-induced thrombocytopenia in the treatment of CML patients is discussed, including imatinib and thrombocytopenia, PDGF/PDGFR and thrombopoiesis, potential mechanism of imatinib-induced thrombocytopenia in treatment of patients with CML and so on.
authors: Department of Hematology, Southern Medical University, Guangdong Province, China.
authors: Ling-Ling
authors: LL
authors: Shu
authors: Qian-Li
authors: QL
authors: Jiang
authors: Fan-Yi
authors: FY
authors: Meng
authors: Mo
authors: M
authors: Yang
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001549:Benzamides; D053148:Caspase 3 / Q000378:metabolism; D006801:Humans; D000068877:Imatinib Mesylate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D010879:Piperazines / Q000009:adverse effects* / Q000627:therapeutic use; D010982:Platelet-Derived Growth Factor / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D011743:Pyrimidines / Q000009:adverse effects* / Q000627:therapeutic use; D015398:Signal Transduction; D013921:Thrombocytopenia / Q000139:chemically induced*; D034061:Thrombopoiesis
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D010982:Platelet-Derived Growth Factor; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D051057:Proto-Oncogene Proteins c-akt; D053148:Caspase 3