title: Interpretation of genotypic resistance to predict darunavir/ritonavir failure in antiretroviral experienced patients.
abstract: From the Italian Antiretroviral Resistance Cohort Analysis database, 1104 patients starting ritonavir-boosted darunavir-containing regimen were included as follows: 118 subsequently failed treatment at a median of 11 months (interquartile range: 5-20); 3 years failure proportion: 24.6%. HIV Drug Resistance Database and ANRS interpretation algorithms were associated with a progressive risk prediction of virological failure at adjusted Cox. In contrast, Rega algorithm allows to identify a higher number of patients at risk of failure, without losing statistical significance. Four mutations (V32I, I50V, L76V, I84V) were predictive of failure, the hazard ratio progressively increased by detecting 1 (hazard ratio: 2.0, 95% confidence interval: 1.3 to 3.0), 2 (3.6, 2.0 to 6.6), or 3 of them (9.7, 2.8 to 33.5).
authors: Azienda Ospedaliera Universitaria Careggi, Dipartimento di Malattie Infettive, Firenze, Italy.
authors: Gaetana
authors: G
authors: Sterrantino
authors: Mauro
authors: M
authors: Zaccarelli
authors: Michele
authors: M
authors: Trotta
authors: Andrea
authors: A
authors: De Luca
authors: Vanni
authors: V
authors: Borghi
authors: Paola
authors: P
authors: Meraviglia
authors: Paola
authors: P
authors: Corsi
authors: Stefano
authors: S
authors: Bonora
authors: Francesco
authors: F
authors: Leoncini
authors: Maurizio
authors: M
authors: Zazzi
mesh_terms: D000328:Adult; D000465:Algorithms; D023241:Antiretroviral Therapy, Highly Active; D000069454:Darunavir; D024921:Drug Resistance, Multiple, Viral / Q000235:genetics*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000235:genetics; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D009154:Mutation; D012307:Risk Factors; D019438:Ritonavir / Q000627:therapeutic use*; D013449:Sulfonamides / Q000627:therapeutic use*; D017211:Treatment Failure
chemical_list: D017320:HIV Protease Inhibitors; D013449:Sulfonamides; D019438:Ritonavir; D000069454:Darunavir