title: A pilot study of nuclear instability in archived renal and upper urinary tract tumours with putative ochratoxin aetiology.
abstract: DNA ploidy measurement has been applied uniquely to wax-embedded tissue of primary renal cell and metastatic tumours of a key experimental researcher on porcine ochratoxicosis, a control, and four transitional cell carcinomas from cases of Balkan endemic nephropathy. Primary renal tumour was diploid, and hyperdiploid metastasis was within the lower ploidy range for typical renal cell carcinoma. Three Balkan primary tumours showed extensive aneuploidy indicating marked nuclear instability, similar to model rat renal carcinoma caused by ochratoxin A. In contrast, much less nuclear instability in the putative occupational ochratoxicosis case fitted poorly with the ochratoxin A model.
authors: Centre for Environmental Policy, Imperial College London, London SW7 2AZ, UK.
authors: Peter G
authors: PG
authors: Mantle
authors: Cyrille
authors: C
authors: Amerasinghe
authors: Amy L
authors: AL
authors: Brown
authors: Diana
authors: D
authors: Herman
authors: Thomas
authors: T
authors: Horn
authors: Thoger
authors: T
authors: Krogh
authors: Edward W
authors: EW
authors: Odell
authors: Tomas
authors: T
authors: Rosenbaum
authors: Calin A
authors: CA
authors: Tatu
mesh_terms: D000368:Aged; D000782:Aneuploidy; D000818:Animals; D001449:Balkan Nephropathy / Q000209:etiology* / Q000473:pathology; D002273:Carcinogens / Q000633:toxicity*; D002292:Carcinoma, Renal Cell / Q000209:etiology* / Q000473:pathology; D002295:Carcinoma, Transitional Cell / Q000209:etiology / Q000473:pathology; D002467:Cell Nucleus / Q000473:pathology; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009793:Ochratoxins / Q000633:toxicity*; D010865:Pilot Projects; D051381:Rats; D014571:Urologic Neoplasms / Q000209:etiology* / Q000473:pathology
chemical_list: D002273:Carcinogens; D009793:Ochratoxins; C025589:ochratoxin A