title: Two outbreaks of virulent systemic feline calicivirus infection in cats in Germany.
abstract: Over the last years, several outbreaks of virulent systemic feline calicivirus (VS-FCV) infection have been described in the USA and several European countries. The paper describes two outbreaks of VS-FCV infection in cats in Germany. Data concerning clinical, laboratory, and histopathological features ofVS-FCV infection were collected from two outbreaks affecting 55 and 4 cats, respectively. Presence of feline calicivirus was confirmed by PCR followed by sequencing of the PCR-products. Clinical signs were variable, including severe upper respiratory tract infection, dyspnoea, oral and footpad ulceration, facial oedema, enteritis, pneumonia, bleeding disorder, high fever, and icterus. Both outbreaks were characterized by a high mortality rate.The present report describes the first documented outbreaks of VS-FCV infection in cats in Germany. Clinical and histopathological features are comparable to outbreaks described in the USA and Europe. However, phylogenetic analysis of the virus genome suggests that virus strains involved in these outbreaks were different from each other and from virulent strains isolated before, confirming the known genetic variability of FCV.
authors: Clinic of Small Animal Medicine, Ludwig Maximilian University, Munich, Germany. b.schulz@medizinische-kleintierklinik.de
authors: Bianka S
authors: BS
authors: Schulz
authors: Katrin
authors: K
authors: Hartmann
authors: Stefan
authors: S
authors: Unterer
authors: Werner
authors: W
authors: Eichhorn
authors: Monir
authors: M
authors: Majzoub
authors: Timo
authors: T
authors: Homeier-Bachmann
authors: Uwe
authors: U
authors: Truyen
authors: Christin
authors: C
authors: Ellenberger
authors: Janine
authors: J
authors: Huebner
mesh_terms: D000818:Animals; D002139:Caliciviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D017250:Caliciviridae Infections / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D002371:Cat Diseases / Q000453:epidemiology* / Q000473:pathology / Q000821:virology; D002415:Cats; D004196:Disease Outbreaks / Q000662:veterinary*; D005260:Female; D005858:Germany / Q000453:epidemiology; D008297:Male; D010802:Phylogeny; D014774:Virulence