title: The implication of functional connectivity strength in predicting treatment response of major depressive disorder: a resting EEG study.
abstract: Predicting treatment response in major depressive disorder (MDD) has been an important clinical issue given that the initial intent-to-treat response rate is only 50 to 60%. This study was designed to examine whether functional connectivity strengths of resting EEG could be potential biomarkers in predicting treatment response at 8 weeks of treatment. Resting state 3-min eyes-closed EEG activity was recorded at baseline and compared in 108 depressed patients. All patients were being treated with selective serotonin-reuptake inhibitors. Baseline coherence and power series correlation were compared between responders and non-responders evaluated at the 8th week by Hamilton Depression Rating Scale. Pearson correlation and receiver operating characteristic (ROC) analyses were applied to evaluate the performance of connectivity strengths in predicting/classifying treatment responses. The connectivity strengths of right fronto-temporal network at delta/theta frequencies differentiated responders and non-responders at the 8th week of treatment, such that the stronger the connectivity strengths, the poorer the treatment response. ROC analyses supported the value of these measures in classifying responders/non-responders. Our results suggest that fronto-temporal connectivity strengths could be potential biomarkers to differentiate responders and slow responders or non-responders in MDD.
authors: Laureate Institute for Brain Research, Tulsa, OK, USA.
authors: Tien-Wen
authors: TW
authors: Lee
authors: Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan.
authors: Yu-Te
authors: YT
authors: Wu
authors: Yu's Psychiatric Clinic, Kaohsiung, Taiwan.
authors: Younger W-Y
authors: YW
authors: Yu
authors: Kai-Suan Psychiatric Hospital, Kaohsiung, Taiwan.
authors: Ming-Chao
authors: MC
authors: Chen
authors: Department of Psychiatry, E-DA Hospital, Kaohsiung County, Taiwan; Department of Occupational Therapy, I-Shou University, Kaohsiung County, Taiwan. Electronic address: ed100239@edah.org.tw.
authors: Tai-Jui
authors: TJ
authors: Chen
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001931:Brain Mapping; D058256:Brain Waves / Q000187:drug effects*; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000503:physiopathology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012146:Rest / Q000502:physiology*; D013997:Time Factors
chemical_list: D000928:Antidepressive Agents