title: [Ten-year follow-up of kidney transplantation with living unrelated donor].
abstract: BACKGROUND
  In the current era of scarcity of kidneys available for transplantation, and chronic anti-HLA-mediated rejection as a main cause of graft loss, continuous demonstration of the long-term survival of grafts from living unrelated kidney donors (LURD) is paramount.
  
  
  OBJECTIVE
  Analyze long-term kidney graft and patient outcomes using LURD, and compare them with living related donors (LRD).
  
  
  METHODS
  We analyzed the 389 first renal transplantations performed with a living donor (281 LRD and 108 LURD), in a single center, from January 1998 through December 2007.
  
  
  RESULTS
  There were no significant differences between LRD and LURD as refers to patient survival (89.1% vs. 84.7%, p = 0.40, respectively) and graft survival (81.1% vs. 68.9%, p = 0.77, respectively), 10 years post-transplantation. On Cox proportional regression model of multivariate analysis, panel reactive antibodies (PRA) > 10% and the occurrence of acute rejection in the first year posttransplantation were the only independent predictors of graft loss (HR 2.54, 95% CI 1.35 -4.78; p < 0.05 and HR 4.1, 95% CI 2.04 - 4.78; p < 0.05, respectively).
  
  
  CONCLUSIONS
  LURD are an important source of organs for renal transplantation, with results similar to those obtained with LRD, regardless of HLA matching.
authors: Faculdade de Medicina, Universidade de São Paulo.
authors: Gustavo Fernandes
authors: GF
authors: Ferreira
authors: Igor Denizarde Bacelar
authors: ID
authors: Marques
authors: Clarice Hyesuk Lee
authors: CH
authors: Park
authors: David José de Barros
authors: DJ
authors: Machado
authors: Francine Brambate Carvalhinho
authors: FB
authors: Lemos
authors: Flávio Jota de
authors: FJ
authors: Paula
authors: William Carlos
authors: WC
authors: Nahas
authors: Elias
authors: E
authors: David-Neto
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors