title: Influence of gestational age and reason for prior preterm birth on rates of recurrent preterm delivery.
abstract: OBJECTIVE
  We sought to compare rates of recurrent spontaneous preterm birth (SPTB) in women receiving 17-α-hydroxyprogesterone caproate (17P) with prior SPTB due to preterm labor (PTL) vs preterm premature rupture of membranes (PPROM).
  
  
  METHODS
  Women with singleton gestation having 1 prior SPTB enrolled at 16-24.9 weeks' gestation for weekly outpatient 17P administration were identified from a database. Rates of recurrent SPTB were compared between those with prior SPTB due to PTL or PPROM overall and by gestational age at prior SPTB.
  
  
  RESULTS
  Records from 2123 women were analyzed. The prior PTL group vs the prior PPROM group experienced higher rates of recurrent SPTB at <37 weeks (29.7% vs 22.9%, P = .004), <35 weeks (14.0% vs 9.1%, P = .004), and <32 weeks (5.9% vs 3.3%, P = .024), respectively.
  
  
  CONCLUSIONS
  Reason and gestational age of prior SPTB influence the likelihood of recurrent SPTB in women receiving 17P prophylaxis.
authors: Department of Obstetrics and Gynecology, University of Miami School of Medicine, Miami, FL, USA.
authors: Victor Hugo
authors: VH
authors: Gonzalez-Quintero
authors: Yvette C
authors: YC
authors: Cordova
authors: Niki B
authors: NB
authors: Istwan
authors: Felipe
authors: F
authors: Tudela
authors: Debbie J
authors: DJ
authors: Rhea
authors: Letty Maria
authors: LM
authors: Romary
authors: Adrian
authors: A
authors: Marimon
authors: Cheryl N
authors: CN
authors: Desch
authors: Gary J
authors: GJ
authors: Stanziano
mesh_terms: D000077713:17 alpha-Hydroxyprogesterone Caproate; D000328:Adult; D000367:Age Factors; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D005865:Gestational Age; D006801:Humans; D006908:Hydroxyprogesterones / Q000627:therapeutic use*; D007231:Infant, Newborn; D007234:Infant, Premature; D011247:Pregnancy; D047928:Premature Birth / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D011372:Progestins / Q000627:therapeutic use*; D055502:Secondary Prevention
chemical_list: D006908:Hydroxyprogesterones; D011372:Progestins; D000077713:17 alpha-Hydroxyprogesterone Caproate