title: Ocular biocompatibility of nitinol intraocular clips.
abstract: OBJECTIVE
  To evaluate the tolerance and biocompatibility of a preformed nitinol intraocular clip in an animal model after anterior segment surgery.
  
  
  METHODS
  Yucatan mini-pigs were used. A 30-gauge prototype injector was used to attach a shape memory nitinol clip to the iris of five pigs. Another five eyes received conventional polypropylene suture with a modified Seipser slip knot. The authors compared the surgical time of each technique. All eyes underwent standard full-field electroretinogram at baseline and 8 weeks after surgery. The animals were euthanized and eyes collected for histologic analysis after 70 days (10 weeks) postsurgery. The corneal thickness, corneal endothelial cell counts, specular microscopy parameters, retina cell counts, and electroretinogram parameters were compared between the groups. A two sample t-test for means and a P value of 0.05 were use for assessing statistical differences between measurements.
  
  
  RESULTS
  The injection of the nitinol clip was 15 times faster than conventional suturing. There were no statistical differences between the groups for corneal thickness, endothelial cell counts, specular microscopy parameters, retina cell counts, and electroretinogram measurements.
  
  
  CONCLUSIONS
  The nitinol clip prototype is well tolerated and showed no evidence of toxicity in the short-term. The injectable delivery system was faster and technically less challenging than conventional suture techniques.
authors: Department of Ophthalmology, University of Colorado Health and Science Center, Rocky Mountain Lions Eye Institute, University of Colorado School of Medicine, Aurora, Colorado, USA. jeffrey.olson@ucdenver.edu
authors: Jeffrey L
authors: JL
authors: Olson
authors: Raul
authors: R
authors: Velez-Montoya
authors: Michael
authors: M
authors: Erlanger
mesh_terms: D000497:Alloys; D000818:Animals; D000869:Anterior Eye Segment / Q000601:surgery*; D001672:Biocompatible Materials; D002452:Cell Count; D055954:Corneal Endothelial Cell Loss / Q000175:diagnosis; D004596:Electroretinography; D004728:Endothelium, Corneal / Q000473:pathology; D005500:Follow-Up Studies; D008422:Materials Testing; D023421:Models, Animal; D011126:Polypropylenes; D012160:Retina / Q000503:physiopathology; D017792:Surgical Stapling / Q000295:instrumentation*; D013536:Suture Techniques; D013537:Sutures; D013552:Swine; D013556:Swine, Miniature; D013997:Time Factors; D041623:Tomography, Optical Coherence
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D011126:Polypropylenes; C013616:nitinol