title: Clostridium perfringens iota-toxin: structure and function.
abstract: Clostridium perfringens iota-toxin is composed of the enzyme component (Ia) and the binding component (Ib). Ib binds to receptor on targeted cells and translocates Ia into the cytosol of the cells. Ia ADP-ribosylates actin, resulting in cell rounding and death. Comparisons of the deduced amino acid sequence from the gene and three-dimensional structure of Ia with those of ADP-ribosylating toxins (ARTs) suggests that there is striking structural similarity among these toxins. Our objectives are to review the recent advances in the character, structure-function, and the mode of action of iota-toxin by consideration of the findings about ARTs.
authors: Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan. sakurai@ph.bunri-u.ac.jp
authors: Jun
authors: J
authors: Sakurai
authors: Masahiro
authors: M
authors: Nagahama
authors: Masataka
authors: M
authors: Oda
authors: Hideaki
authors: H
authors: Tsuge
authors: Keiko
authors: K
authors: Kobayashi
mesh_terms: D000199:Actins / Q000378:metabolism; D000595:Amino Acid Sequence; D003016:Clostridium perfringens / Q000378:metabolism; D006801:Humans
chemical_list: D000199:Actins