title: [Effects of local application of zoledronic acid on bone healing of tooth extraction in rats].
abstract: OBJECTIVE
  To investigate the effect of local application of zoledronic acid (ZA) on the expression of type I collagen and vascular endothelial growth factor (VEGF).
  
  
  METHODS
  Fifty-four male Wistar rats were divided into ZA group, gelatin sponge group, and blank control group after one-side tooth extraction. The expression of type I collagen and VEGF were detected with SP immunohistochemistry method 1, 2 and 4 weeks after operation.
  
  
  RESULTS
  The gray value of type I collagen in ZA group (60.00 ± 1.81, 63.47 ± 3.02) was lower than those in gelatin sponge group (68.58 ± 2.90, 71.15 ± 5.57) and blank control group (69.16 ± 9.63, 72.50 ± 4.10, P < 0.05) in the 1 and 2 week. In the ZA and gelatin sponge groups, the gray values of type I collagen were higher in the 4th week than in the 1st and 2nd week (P < 0.05). The expression of VEGF was higher in ZA group (69.93 ± 2.74) than in gelatin sponge group (60.86 ± 4.79) and blank control group (61.52 ± 2.28) in the 1st week (P < 0.05). There was significant difference in VEGF expression between the 2nd week and 1st and 4th week (P < 0.05).
  
  
  CONCLUSIONS
  Local application of ZA could enhance the expression of type I collagen but inhibit the expression of VEGF in the early stage.
authors: Department of Prosthodontics, Stomatological Hospital, Tianjin Medical University, Tianjin, China.
authors: Ting
authors: T
authors: Ma
authors: Wen-yi
authors: WY
authors: Zhang
authors: Jian
authors: J
authors: Zhang
authors: Ming
authors: M
authors: Wang
authors: Cai-wen
authors: CW
authors: Cui
mesh_terms: D000287:Administration, Topical; D000818:Animals; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001861:Bone Regeneration / Q000187:drug effects; D004164:Diphosphonates / Q000008:administration & dosage / Q000494:pharmacology*; D007093:Imidazoles / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014081:Tooth Extraction; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D042461:Vascular Endothelial Growth Factor A; C467498:vascular endothelial growth factor A, rat; D000077211:Zoledronic Acid