title: Substitution behaviour of novel dinuclear Pt(II) complexes with bio-relevant nucleophiles.
abstract: The novel dinuclear Pt(II) complexes [{trans-Pt(NH(3))(2)Cl}(2)(μ-pyrazine)](ClO(4))(2) (Pt1), [{trans-Pt(NH(3))(2)Cl}(2)(μ-4,4'-bipyridyl)](ClO(4))(2)·DMF (Pt2), and [{trans-Pt(NH(3))(2)Cl}(2)(μ-1,2-bis(4-pyridyl)ethane)](ClO(4))(2) (Pt3), were synthesized. Acid-base titrations, and temperature and concentration dependent kinetic measurements of the reactions with biologically relevant ligands such as thiourea (Tu), glutathione (GSH) and guanosine-5'-monophosphate (5'-GMP) were studied at pH 2.5 and 7.2. The reactions were followed under pseudo-first-order conditions by stopped-flow and UV-vis spectrophotometry. (1)H NMR spectroscopy was used to follow the substitution of chloride in the complex [{trans-Pt(NH(3))(2)Cl}(2)(μ-4,4'-bipyridyl)](ClO(4))(2)·DMF by guanosine-5'-monophosphate (5'-GMP) under second-order conditions. The results indicate that the bridging ligand has an influence on the reactivity of the complexes towards nucleophiles. The order of reactivity of the investigated complexes is Pt1 > Pt2 > Pt3.
authors: Department of Chemical-Technological Sciences, State University of Novi Pazar, 36300, Novi Pazar, Serbia.
authors: Tanja
authors: T
authors: Soldatović
authors: Snežana
authors: S
authors: Jovanović
authors: Živadin D
authors: ŽD
authors: Bugarčić
authors: Rudi
authors: R
authors: van Eldik
mesh_terms: D006157:Guanosine Monophosphate / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D009944:Organoplatinum Compounds; D010984:Platinum; D006157:Guanosine Monophosphate