title: Taming the Friedel-Crafts reaction: organocatalytic approach to optically active 2,3-dihydrobenzofurans.
abstract: Fine-tuning: Three types of optically active trans-2,3-disubstituted-2,3-dihydrobenzofurans having three contiguous stereogenic centers can be efficiently accessed by one-pot reaction cascades (see scheme; TMS = trimethylsilyl). High substitution diversity of the final products can be achieved from the same common precursors by fine-tuning of their reactivity through simple structural modifications.
authors: Center for Catalysis, Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark.
authors: Łukasz
authors: Ł
authors: Albrecht
authors: Lars Krogager
authors: LK
authors: Ransborg
authors: Vibeke
authors: V
authors: Lauridsen
authors: Mette
authors: M
authors: Overgaard
authors: Theo
authors: T
authors: Zweifel
authors: Karl Anker
authors: KA
authors: Jørgensen
mesh_terms: D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001572:Benzofurans; C043168:coumaran