title: Blockade of cytotoxic T-lymphocyte antigen-4 by ipilimumab is associated with a profound long-lasting depletion of Foxp3+ regulatory T cells: a mechanistic explanation for ipilimumab-induced severe enterocolitis?
authors: S
authors: S
authors: Nancey
authors: G
authors: G
authors: Boschetti
authors: E
authors: E
authors: Cotte
authors: K
authors: K
authors: Ruel
authors: T
authors: T
authors: Almeras
authors: M
authors: M
authors: Chauvenet
authors: K
authors: K
authors: Stroeymeyt
authors: D
authors: D
authors: Moussata
authors: D
authors: D
authors: Kaiserlian
authors: B
authors: B
authors: Flourié
mesh_terms: D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D060908:CTLA-4 Antigen / Q000037:antagonists & inhibitors* / Q000276:immunology; D004760:Enterocolitis / Q000139:chemically induced / Q000276:immunology / Q000473:pathology*; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D006801:Humans; D000074324:Ipilimumab; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D000074324:Ipilimumab