title: Evaluation of biomarkers of oxidative stress and antioxidant capacity in the cord blood of preterm low birth weight neonates.
abstract: OBJECTIVE
  The objective of the study is to investigate the association between oxidative stress markers and enzymatic / non-enzymatic antioxidants (marker of the resistance in body to oxidative damage) in the cord blood of preterm low birth weight (LBW) neonates.
  
  
  METHODS
  Malondialdehyde (MDA), carbonyl proteins, total antioxidant capacity and Vitamin A, E and C levels in the cord blood were determined by spectrophotometry.
  
  
  RESULTS
  Increased lipid peroxidation, protein oxidation with decreased values of vitamin A, E, C and total antioxidant capacity were observed in the preterm LBW newborns. Observations of negative correlation between MDA and protein carbonyl with antioxidants vitamin A, E and C and total antioxidant status points towards the existence of oxidative stress in the preterm LBW newborns.
  
  
  CONCLUSIONS
  Poor fetal growth affects the development of antioxidant defenses of preterm LBW babies, predisposing them to higher oxidative stress, which in turn may partly account for increased morbidity and mortality in these infants. The presence of an association between oxidative stress biomarkers and enzymatic /non-enzymatic antioxidants in the cord blood of preterm LBW neonates suggest that increased oxidative stress may be the result of changes in the levels of certain enzymatic and non-enzymatic antioxidants due to the cause or the effect of oxidative damage occurring at the molecular level.
authors: Department of Biophysics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
authors: Reena
authors: R
authors: Negi
authors: Deepti
authors: D
authors: Pande
authors: Ashok
authors: A
authors: Kumar
authors: Ranjana S
authors: RS
authors: Khanna
authors: H D
authors: HD
authors: Khanna
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000032:analysis / Q000378:metabolism*; D001205:Ascorbic Acid / Q000032:analysis / Q000097:blood / Q000378:metabolism; D015415:Biomarkers / Q000032:analysis / Q000097:blood* / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D005312:Fetal Blood / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007230:Infant, Low Birth Weight / Q000097:blood* / Q000378:metabolism; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood* / Q000378:metabolism; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D011247:Pregnancy; D050050:Protein Carbonylation / Q000502:physiology; D014801:Vitamin A / Q000032:analysis / Q000097:blood / Q000378:metabolism; D014810:Vitamin E / Q000032:analysis / Q000097:blood / Q000378:metabolism; D055815:Young Adult
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D014801:Vitamin A; D014810:Vitamin E; D008315:Malondialdehyde; D001205:Ascorbic Acid