title: [A new water-soluble lubricant of tablets-L-leucine combined with PEG6000].
abstract: OBJECTIVE
  To prepare an effective and water-soluble lubricant.
  
  
  METHODS
  Co-sprayed lubricant (L-leucine and polyethylene glycol 6000 co-sprayed according to a certain proportion) and mixed lubricant (the physical mixture of spayed L-leucine and crushed polyethylene glycol 6000) were prepared and polyethylene glycol 6000, L-leucine, magnesium stearate, sodium stearyl fumarate and sodium chloride are crushed and sieved, respectively. Residual force, appearance of solution and disintegration time were considered as response variables of the lubrication effect to evaluate different lubricants. The changes of the co-sprayed lubricant were studied by differential scanning calorimetry, fourier infrared, electronic scanning microscope and X-ray diffraction.
  
  
  RESULTS
  The efficacy of co-sprayed lubricant is better than other lubricants. Efficacy is improved by external form change without inner components and crystal changes.
  
  
  CONCLUSIONS
  Co-sprayed lubricant is a good water soluble tablet lubricant which has good efficacy.
authors: Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. 313061304@qq.com
authors: Wei
authors: W
authors: Liu
authors: Kai
authors: K
authors: Huang
authors: Xiaoyong
authors: X
authors: Rao
authors: Xiaoyan
authors: X
authors: Liu
authors: Shasha
authors: S
authors: Sun
authors: Xiaojian
authors: X
authors: Luo
mesh_terms: D002626:Chemistry, Pharmaceutical; D007930:Leucine / Q000737:chemistry*; D054327:Lubricants / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012995:Solubility; D013607:Tablets; D014867:Water; D014961:X-Ray Diffraction
chemical_list: D054327:Lubricants; D013607:Tablets; D014867:Water; D011092:Polyethylene Glycols; D007930:Leucine