title: Acute liver failure in young children with systemic-onset juvenile idiopathic arthritis without macrophage activation syndrome: report of two cases.
abstract: Acute liver failure (ALF) with macrophage activation syndrome (MAS) is well known as a complication of systemic-onset juvenile idiopathic arthritis (S-JIA). However, liver failure without overt MAS is rare in S-JIA. We encountered two Japanese children with S-JIA in whom ALF developed during the remission of clinical manifestations. ALF without MAS was improved with plasma exchange and cyclosporine A combined with pulse methylprednisolone.
authors: Department of Pediatrics, Eastern Yokohama Hospital, Yokohama, Japan.
authors: Eitaro
authors: E
authors: Hiejima
authors: Haruki
authors: H
authors: Komatsu
authors: Yoshitake
authors: Y
authors: Takeda
authors: Tsuyoshi
authors: T
authors: Sogo
authors: Ayano
authors: A
authors: Inui
authors: Ikuo
authors: I
authors: Okafuji
authors: Ryuta
authors: R
authors: Nishikomori
authors: Tatsutoshi
authors: T
authors: Nakahata
authors: Tomoo
authors: T
authors: Fujisawa
mesh_terms: D001171:Arthritis, Juvenile / Q000150:complications / Q000503:physiopathology*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D017114:Liver Failure, Acute / Q000150:complications / Q000503:physiopathology*; D008262:Macrophage Activation; D008297:Male; D016706:Still's Disease, Adult-Onset