title: Isoflurane anesthesia preserves liver and lung mitochondrial oxidative capacity after gut ischemia-reperfusion.
abstract: BACKGROUND
  Lung and liver dysfunction is involved in gut ischemia-reperfusion (IR)-induced multiple organ failure. We compared the effects of ketamine and isoflurane on liver and lung mitochondrial oxidative capacity after gut IR.
  
  
  METHODS
  Adult male Wistar rats were randomized into 4 groups (controls and gut IR receiving either intraperitoneal ketamine or inhaled isoflurane). Maximal oxygen consumption and the activity of respiratory chain complexes were measured on isolated liver and lung mitochondria.
  
  
  RESULTS
  Gut IR significantly impaired liver and lung mitochondrial oxidative capacity when using ketamine but not isoflurane.
  
  
  CONCLUSIONS
  Isoflurane preserved liver and lung mitochondrial oxidative capacity after gut IR.
authors: Pôle Anesthésie Réanimation Chirurgicale, SAMU, Hôpitaux Universitaires de Strasbourg, Avenue Molière, 67098 Strasbourg, France. olivier.collange@chru-strasbourg.fr
authors: Olivier
authors: O
authors: Collange
authors: Anne-Laure
authors: AL
authors: Charles
authors: Eric
authors: E
authors: Noll
authors: Jamal
authors: J
authors: Bouitbir
authors: Joffrey
authors: J
authors: Zoll
authors: François
authors: F
authors: Piquard
authors: Pierre
authors: P
authors: Diemunsch
authors: Bernard
authors: B
authors: Geny
mesh_terms: D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D000818:Animals; D041981:Gastrointestinal Tract / Q000098:blood supply* / Q000187:drug effects / Q000378:metabolism; D007530:Isoflurane / Q000008:administration & dosage*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects / Q000502:physiology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000209:etiology / Q000378:metabolism*
chemical_list: D018685:Anesthetics, Inhalation; D007530:Isoflurane