title: The spiFEG locus in Streptococcus infantarius subsp. infantarius BAA-102 confers protection against nisin U.
abstract: Nisin U is a member of the extended nisin family of lantibiotics. Here we identify the presence of nisin U immunity gene homologues in Streptococcus infantarius subsp. infantarius BAA-102. Heterologous expression of these genes in Lactococcus lactis subsp. cremoris HP confers protection to nisin U and other members of the nisin family, thereby establishing that the recently identified phenomenon of resistance through immune mimicry also occurs with respect to nisin.
authors: Department of Microbiology, University College Cork, Cork, Ireland.
authors: Lorraine A
authors: LA
authors: Draper
authors: John R
authors: JR
authors: Tagg
authors: Colin
authors: C
authors: Hill
authors: Paul D
authors: PD
authors: Cotter
authors: R Paul
authors: RP
authors: Ross
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis; D001430:Bacteriocins / Q000096:biosynthesis* / Q000235:genetics; D004269:DNA, Bacterial; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli; D015870:Gene Expression; D005798:Genes, Bacterial; D056426:Genetic Loci; D013294:Lactococcus lactis / Q000235:genetics* / Q000378:metabolism; D018716:Molecular Mimicry; D009561:Nisin / Q000096:biosynthesis* / Q000235:genetics; D013291:Streptococcus / Q000235:genetics* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001430:Bacteriocins; D004269:DNA, Bacterial; D009561:Nisin