title: Photoprotective effects of a formulation containing tannase-converted green tea extract against UVB-induced oxidative stress in hairless mice.
abstract: Ultraviolet B (UVB) irradiation may induce the acceleration of skin aging. The purpose of this study was to develop an effective formulation containing tannase-converted green tea extract (FTGE) to inhibit UVB-induced oxidative damage. Significant (p<0.05) prevention of the reduced form of glutathione (GSH) depletion was observed in mice treated with FTGE. The hydrogen peroxide levels of mice treated with FTGE were similar to those of UVB non-irradiated mice. No significant difference was observed between No UVB control and FTGE mice. Also, mice treated with FTGE had significant (p<0.05) decreases in thiobarbituric acid-reactive substance levels by lipid peroxidation compared with No UVB control mice. Our data suggest that this formulation may be effective in protecting skin from UVB photodamage.
authors: Research Institute of Health and Sciences, Korea University, Seoul, Republic of Korea.
authors: Yang-Hee
authors: YH
authors: Hong
authors: Eun Young
authors: EY
authors: Jung
authors: Kwang-Soon
authors: KS
authors: Shin
authors: Tae Young
authors: TY
authors: Kim
authors: Kwang-Won
authors: KW
authors: Yu
authors: Un Jae
authors: UJ
authors: Chang
authors: Hyung Joo
authors: HJ
authors: Suh
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D002265:Carboxylic Ester Hydrolases / Q000737:chemistry / Q000494:pharmacology*; D002392:Catechin / Q000737:chemistry; D006861:Hydrogen Peroxide / Q000378:metabolism; D015227:Lipid Peroxidation / Q000502:physiology; D051379:Mice; D008812:Mice, Hairless; D018384:Oxidative Stress / Q000502:physiology; D010936:Plant Extracts / Q000494:pharmacology*; D020011:Protective Agents / Q000737:chemistry / Q000494:pharmacology*; D013662:Tea / Q000737:chemistry*; D014466:Ultraviolet Rays / Q000009:adverse effects
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D020011:Protective Agents; D013662:Tea; D002392:Catechin; D006861:Hydrogen Peroxide; D002265:Carboxylic Ester Hydrolases; C022711:tannase