title: Toward an image-guided microbeam radiation therapy using gadolinium-based nanoparticles.
abstract: Ultrasmall gadolinium-based nanoparticles (GBNs) induce both a positive contrast for magnetic resonance imaging and a radiosentizing effect. The exploitation of these characteristics leads to a greater increase in lifespan of rats bearing brain tumors since the radiosensitizing effect of GBNs can be activated by X-ray microbeams when the gadolinium content is, at the same time, sufficiently high in the tumor and low in the surrounding healthy tissue. GBNs exhibit therefore an interesting potential for image-guided radiotherapy.
authors: ID17 Biomedical Beamline, European Synchrotron Radiation Facility, 6 Rue Jules Horowitz, 38000 Grenoble, France.
authors: Géraldine
authors: G
authors: Le Duc
authors: Imen
authors: I
authors: Miladi
authors: Christophe
authors: C
authors: Alric
authors: Pierre
authors: P
authors: Mowat
authors: Elke
authors: E
authors: Bräuer-Krisch
authors: Audrey
authors: A
authors: Bouchet
authors: Enam
authors: E
authors: Khalil
authors: Claire
authors: C
authors: Billotey
authors: Marc
authors: M
authors: Janier
authors: François
authors: F
authors: Lux
authors: Thierry
authors: T
authors: Epicier
authors: Pascal
authors: P
authors: Perriat
authors: Stéphane
authors: S
authors: Roux
authors: Olivier
authors: O
authors: Tillement
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000473:pathology* / Q000532:radiotherapy*; D003287:Contrast Media / Q000627:therapeutic use; D005682:Gadolinium / Q000627:therapeutic use*; D053758:Nanoparticles / Q000627:therapeutic use*; D020266:Radiotherapy, Conformal / Q000379:methods*; D061089:Radiotherapy, Image-Guided / Q000379:methods*; D051381:Rats; D016896:Treatment Outcome
chemical_list: D003287:Contrast Media; D005682:Gadolinium