title: Intrauterine injection of human chorionic gonadotropin before embryo transfer significantly improves the implantation and pregnancy rates in in vitro fertilization/intracytoplasmic sperm injection: a prospective randomized study.
abstract: OBJECTIVE
  To investigate the value of intrauterine injection of human chorionic gonadotropin (hCG) before embryo transfer (ET).
  
  
  METHODS
  Prospective randomized study.
  
  
  METHODS
  The Egyptian IVF-ET Center.
  
  
  METHODS
  Infertility patients younger than 40 years undergoing their first in vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI).
  
  
  METHODS
  The study group (n = 167) received either 100 IU of hCG (n = 83), or 200 IU of hCG (n = 84) via intrauterine administration before ET. The control group (n = 93) underwent ET without hCG. After the interim analysis, the modified study group (n = 107) received intrauterine injection of 500 IU of hCG, and the control group (n = 105) underwent ET without hCG.
  
  
  METHODS
  Clinical pregnancy rate (PR) and implantation rate (IR).
  
  
  RESULTS
  The IR and PR were statistically significantly higher in the 500 hCG group (41.6% and 75%, respectively) as compared with the control group (29.5% and 60%, respectively). The IR and PR were 26.6% and 54% in the 100 hCG group, 28.3% and 57% in the 200 IU hCG group, and 29.4% and 60% in the control group, respectively, with no statistically significant difference.
  
  
  CONCLUSIONS
  Intrauterine injection of 500 IU of hCG before ET statistically significantly improved the implantation and pregnancy rates in IVF/ICSI. CLINICAL TRIALS.GOV NUMBER: NCT 01030393.
authors: The Egyptian IVF-ET Center, Cairo, Egypt. ragaa.mansour@gmail.com
authors: Ragaa
authors: R
authors: Mansour
authors: Nevine
authors: N
authors: Tawab
authors: Omnia
authors: O
authors: Kamal
authors: Yahia
authors: Y
authors: El-Faissal
authors: Ahmed
authors: A
authors: Serour
authors: Mohamed
authors: M
authors: Aboulghar
authors: Gamal
authors: G
authors: Serour
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage* / Q000494:pharmacology*; D004334:Drug Administration Schedule; D010064:Embryo Implantation / Q000187:drug effects*; D004624:Embryo Transfer / Q000379:methods*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D006801:Humans; D007267:Injections; D011247:Pregnancy; D018873:Pregnancy Rate; D020554:Sperm Injections, Intracytoplasmic; D013997:Time Factors; D015854:Up-Regulation; D014599:Uterus; D055815:Young Adult
chemical_list: D006063:Chorionic Gonadotropin