title: An initial miscarriage is associated with adverse pregnancy outcomes in the following pregnancy.
abstract: OBJECTIVE
  The objective of the study was to determine whether 1 previous miscarriage is associated with an increased rate of adverse pregnancy outcomes in the following pregnancy.
  
  
  METHODS
  Second pregnancies of women with and without a miscarriage in their initial pregnancy were compared. Multivariable logistic regression models were constructed to control for confounders.
  
  
  RESULTS
  Of 35,125 singleton deliveries in the second pregnancy, 5777 (16.4%) were of patients with an initial miscarriage. Multivariable analysis showed a significant association between a previous miscarriage and the following adverse pregnancy outcomes including premature rupture of membranes (odds ratio [OR], 2.22; 95% confidence interval [CI], 2.01-2.44), preterm delivery (OR, 1.34; 95% CI, 1.21-1.48), intrauterine growth restriction (OR, 1.24; 95% CI, 1.04-1.47), hypertensive disorders (OR 1.41; 95% CI 1.07-1.85), preeclampsia (OR, 1.63; 95% CI, 1.22-2.18), and cesarean delivery (OR, 1.59; 95% CI, 1.46-1.73). Perinatal mortality was significantly higher among women with an initial miscarriage (1.6% vs 1.0%; P < .001).
  
  
  CONCLUSIONS
  An initial miscarriage is independently associated with adverse pregnancy outcomes.
authors: Department of Obstetrics and Gynecology, Soroka University Medical Center, Israel.
authors: Adi Y
authors: AY
authors: Weintraub
authors: Ruslan
authors: R
authors: Sergienko
authors: Avi
authors: A
authors: Harlev
authors: Gershon
authors: G
authors: Holcberg
authors: Moshe
authors: M
authors: Mazor
authors: Arnon
authors: A
authors: Wiznitzer
authors: Eyal
authors: E
authors: Sheiner
mesh_terms: D000022:Abortion, Spontaneous; D002585:Cesarean Section; D036861:Delivery, Obstetric; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology*; D005322:Premature Rupture of Fetal Membranes / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D054238:Perinatal Mortality; D011225:Pre-Eclampsia / Q000209:etiology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000209:etiology*; D012306:Risk