title: Anti-tumor activity of immunomodulatory peptide alloferon-1 in mouse tumor transplantation model.
abstract: Alloferons are a group of antiviral and anti-tumor peptides primarily isolated from insects and stimulating cytotoxic activity of natural killer cells in mammals including mice and humans. Alloferon-1 is currently used in the treatment of persistent viral infections; however its anti-tumor potential needs further preclinical assessment. Here we evaluate alloferon-1 anti-tumor activity in DBA/2 mice grafted with syngenic P388 murine leukemia cells. Alloferon-1 was applied alone or in combination with conventional cytotoxic chemotherapy (a mixture of cyclophosphamide, doxorubicin and vincristine). Alloferon-1 monotherapy demonstrated moderate tumoristatic and tumoricidal activities comparable with low dose chemotherapy. When alloferon-1 and the cytotoxic drugs were combined in a regime of pulse immunochemotherapy the combination anti-tumor activity evidently exceeded that of the treatments applied individually.
authors: Laboratory of Insect Biopharmacology and Immunology, Faculty of Biology and Soil Science, St. Petersburg State University, St. Petersburg 198904, Oranienbaumskoye Shosse 2, Russia. sichernysh@yahoo.com
authors: Sergey
authors: S
authors: Chernysh
authors: Kozuharova
authors: K
authors: Irina
authors: Artsibasheva
authors: A
authors: Irina
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D007155:Immunologic Factors / Q000627:therapeutic use*; D051379:Mice; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D010455:Peptides / Q000627:therapeutic use*; D047368:Tumor Burden / Q000187:drug effects
chemical_list: C510535:Alloferon; D000970:Antineoplastic Agents; D007155:Immunologic Factors; D010455:Peptides