title: Disseminated hypertrophic lichen planus: relevant response to acitretin.
abstract: Hyperthrofic lichen planus is considered a variant of lichen planus with marked epidermal hyperplasia in response to persistent itch. It is clinically, characterized by symmetric hyperkeratotic plaques, of purplish-grey color, often located in the pretibial region. Intense pruritus, refractoriness to conventional treatments and the possibility of association of the long-term injuries with squamous cell carcinoma requires an effective treatment. The first-line treatment is corticosteroids which can be applied either topically or systemically. Other therapeutic modalities proposed are: NB-UVB phototherapy or PUVA, immunosuppressive drugs and systemic retinoids, notably acitretin. We report a case with exuberant clinical presentation of hyperthrofic lichen planus with excellent response to acitretin after nine months of treatment.
authors: Hospital Naval Marcílio Dias, Rio de Janeiro, Brasil. thaisjerez@yahoo.com.br
authors: Thais Jerez
authors: TJ
authors: Jaime
authors: Tatiana Jerez
authors: TJ
authors: Jaime
authors: Bianca de Mello
authors: Bde M
authors: Guaraldi
authors: Daniel Fernandes
authors: DF
authors: Melo
authors: Thiago
authors: T
authors: Jeunon
authors: Claudio
authors: C
authors: Lerer
mesh_terms: D017255:Acitretin / Q000627:therapeutic use*; D005260:Female; D006229:Hand Dermatoses / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007641:Keratolytic Agents / Q000627:therapeutic use*; D008010:Lichen Planus / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged
chemical_list: D007641:Keratolytic Agents; D017255:Acitretin