title: Flexible oligocholate foldamers as membrane transporters and their guest-dependent transport mechanism.
abstract: Dimeric, trimeric, and tetrameric oligocholates with flexible 4-aminobutyroyl spacers caused the efflux of hydrophilic molecules such as carboxyfluorescein (CF) and glucose from POPC/POPG liposomes. Transport was greatly suppressed across higher-melting DPPC membranes. Lipid-mixing assays and dynamic light scattering (DLS) indicated that the liposomes were intact during the transport. Kinetic analysis supported the involvement of monomeric species in the rate-limiting step of CF transport, consistent with a carrier-based mechanism. Glucose transport, on the other hand, displayed a highly unusual zero-order dependence on the oligocholate concentration at low loading of the transporter. Different selectivity was observed in the oligocholate transporters depending on the guest involved.
authors: Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.
authors: Shiyong
authors: S
authors: Zhang
authors: Yan
authors: Y
authors: Zhao
mesh_terms: D015060:1,2-Dipalmitoylphosphatidylcholine / Q000737:chemistry*; D020355:Cholates / Q000737:chemistry*; D005947:Glucose / Q000737:chemistry*; D008567:Membranes, Artificial; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D020355:Cholates; D008567:Membranes, Artificial; D015060:1,2-Dipalmitoylphosphatidylcholine; D005947:Glucose