title: Differential accumulation of BPA in some tissues of offspring of Balb-C mice exposed to different BPA doses.
abstract: Pregnant adult Balb-C mice were exposed daily to two different doses of Bisphenol A (BPA) by subcutaneous injection beginning on gestational day 1 through the seventh day after delivery. The mothers were sacrificed on postpartum day 21, and the offspring were sacrificed at 3 months of age. Control mice were subjected to the same experimental protocol but received saline injections. The liver, muscles, hindbrain and forebrain of the offspring were dissected and processed using HPLC to assess the level of BPA in the tissues and to determine its dependence on the exposure dose and gender. For comparison, the same tissues were dissected from the mothers and analysed. We report the following results: (1) the level of BPA that accumulated in a given tissue was dependent on the exposure dose; (2) the rank order of BPA accumulation in the various tissues was dependent on the gender of the offspring; (3) the average BPA concentrations in the liver and muscle of the female offspring were higher than in the males; and (4) the average BPA concentration in the central nervous system (i.e., the hindbrain and forebrain) of the male offspring was higher than in the females.
authors: National Institute of Biostructures and Biosystems (INBB), Viale Medaglie d'Oro 305, 00136 Rome, Italy.
authors: L
authors: L
authors: Mita
authors: A
authors: A
authors: Baldi
authors: N
authors: N
authors: Diano
authors: E
authors: E
authors: Viggiano
authors: M
authors: M
authors: Portaccio
authors: C
authors: C
authors: Nicolucci
authors: L
authors: L
authors: Grumiro
authors: C
authors: C
authors: Menale
authors: D G
authors: DG
authors: Mita
authors: E P
authors: EP
authors: Spugnini
authors: R
authors: R
authors: Viceconte
authors: G
authors: G
authors: Citro
authors: R
authors: R
authors: Pierantoni
authors: V
authors: V
authors: Sica
authors: M
authors: M
authors: Marino
authors: P G
authors: PG
authors: Signorile
authors: M
authors: M
authors: Bianco
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds; D004968:Estrogens, Non-Steroidal / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010636:Phenols / Q000008:administration & dosage / Q000378:metabolism*; D011247:Pregnancy; D014018:Tissue Distribution; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004968:Estrogens, Non-Steroidal; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds