title: Novel roles of SoxR, a transcriptional regulator from Xanthomonas campestris, in sensing redox-cycling drugs and regulating a protective gene that have overall implications for bacterial stress physiology and virulence on a host plant.
abstract: In Xanthomonas campestris pv. campestris, SoxR likely functions as a sensor of redox-cycling drugs and as a transcriptional regulator. Oxidized SoxR binds directly to its target site and activates the expression of xcc0300, a gene that has protective roles against the toxicity of redox-cycling compounds. In addition, SoxR acts as a noninducible repressor of its own expression. X. campestris pv. campestris requires SoxR both for protection against redox-cycling drugs and for full virulence on a host plant. The X. campestris model of the gene regulation and physiological roles of SoxR represents a novel variant of existing bacterial SoxR models.
authors: Laboratory of Biotechnology, Chulabhorn Research Institute, Bangkok, Thailand.
authors: Aekkapol
authors: A
authors: Mahavihakanont
authors: Nisanart
authors: N
authors: Charoenlap
authors: Poommaree
authors: P
authors: Namchaiw
authors: Warawan
authors: W
authors: Eiamphungporn
authors: Sorayut
authors: S
authors: Chattrakarn
authors: Paiboon
authors: P
authors: Vattanaviboon
authors: Skorn
authors: S
authors: Mongkolsuk
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D001483:Base Sequence; D054884:Host-Pathogen Interactions; D008969:Molecular Sequence Data; D010084:Oxidation-Reduction; D010935:Plant Diseases / Q000382:microbiology; D011401:Promoter Regions, Genetic; D031224:Raphanus / Q000382:microbiology; D013312:Stress, Physiological; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014774:Virulence; D016959:Xanthomonas campestris / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity
chemical_list: D001426:Bacterial Proteins; D014157:Transcription Factors; C070724:SoxR protein, Bacteria