title: Staged bone grafting following placement of an antibiotic spacer block for the management of segmental long bone defects.
abstract: Segmental long bone defects resulting from injury or surgical intervention are difficult problems to manage. Amputation, external fixators, vascularized fibular grafts, acute limb shortening, and various quantities of allograft and autograft have historically been the mainstays of treatment. Recently, the use of osteoinductive substances such as recombinant bone morphogenic proteins, and osteoconductive scaffolds such as calcium phosphate have found use in the treatment of these clinical situations. More recently, Masquelet described the use of a cement spacer placed within the osseous void followed by staged bone grafting within the induced biomembrane formed around the spacer as a potential treatment strategy to manage these large defects.This article describes a series of 11 patients for which we used this technique of staged bone grafting following placement of an antibiotic spacer to successfully manage osseous long bone defects ranging from 4 to 15 cm. The limbs were stabilized and aligned at the time of initial spacer placement with a plate and screw construct, intramedullary nail, or fine wire fixator. Osteoinductive substances including bone morphogenic protein-2 and platelet rich concentrate were used in addition to allograft to improve bony healing. In our series, osseous consolidation and full weight bearing was achieved in 10 of 11 patients. Two patients developed heterotopic ossification. There was 1 non-union and 1 infection, which occurred in the same patient. Staged bone grafting within an induced biomembrane created after the use of a cement spacer is a reasonable option in the management of both acute and delayed segmental long bone defects.
authors: Department of Orthopaedic Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania, USA.
authors: Derek J
authors: DJ
authors: Donegan
authors: John
authors: J
authors: Scolaro
authors: Paul E
authors: PE
authors: Matuszewski
authors: Samir
authors: S
authors: Mehta
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001672:Biocompatible Materials; D001843:Bone Cements; D001847:Bone Diseases / Q000473:pathology / Q000601:surgery*; D016025:Bone Transplantation / Q000379:methods*; D002484:Cementation; D005260:Female; D005269:Femur / Q000473:pathology / Q000601:surgery*; D050723:Fractures, Bone / Q000473:pathology / Q000601:surgery*; D005597:Fractures, Open / Q000473:pathology / Q000601:surgery; D005599:Fractures, Ununited / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D016348:Osseointegration / Q000187:drug effects; D009999:Ossification, Heterotopic / Q000209:etiology; D010012:Osteogenesis / Q000187:drug effects; D011183:Postoperative Complications; D011474:Prosthesis Design; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D001843:Bone Cements