title: Uncoupling of T cell receptor zeta chain function during the induction of anergy by the superantigen, staphylococcal enterotoxin A.
abstract: Staphylococcus aureus enterotoxins have immunomodulatory properties. In this study, we show that Staphylococcal enterotoxin A (SEA) induces a strong proliferative response in a murine T cell clone independent of MHC class II bearing cells. SEA stimulation also induces a state of hypo-responsiveness (anergy). We characterized the components of the T cell receptor (TCR) during induction of anergy by SEA. Most interestingly, TCR zeta chain phosphorylation was absent under SEA anergizing conditions, which suggests an uncoupling of zeta chain function. We characterize here a model system for studying anergy in the absence of confounding costimulatory signals.
authors: FELS Institute, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140, USA. cornwell@temple.edu
authors: William D
authors: WD
authors: Cornwell
authors: Thomas J
authors: TJ
authors: Rogers
mesh_terms: D000818:Animals; D017635:Clonal Anergy / Q000276:immunology*; D004768:Enterotoxins / Q000276:immunology*; D051379:Mice; D008809:Mice, Inbred C3H; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D018089:Superantigens / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D004768:Enterotoxins; D011948:Receptors, Antigen, T-Cell; D018089:Superantigens; C026066:enterotoxin A, Staphylococcal