title: Coupling of osteogenesis and angiogenesis in bone substitute healing - a brief overview.
abstract: Similar to osteogenesis and bone repair, the healing and osteogenesis of bone substitutes depend on the osteogenesis-angiogenesis interplay which is controlled by different factors, including VEGF or by hypoxia. A brief review of the process of bone substitute angiogenesis is presented and illustrated by our histological and immunohistochemical findings taken from human biopsies after augmentation with a nanocrystalline synthetic bone substitute.
authors: Department of Orthodontics, University of Bonn, Germany. wgoetz@uni-bonn.de
authors: Werner
authors: W
authors: Götz
authors: Christoph
authors: C
authors: Reichert
authors: Luigi
authors: L
authors: Canullo
authors: Andreas
authors: A
authors: Jäger
authors: Friedhelm
authors: F
authors: Heinemann
mesh_terms: D018786:Bone Substitutes; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology; D007150:Immunohistochemistry; D053758:Nanoparticles; D018919:Neovascularization, Physiologic / Q000502:physiology*; D010012:Osteogenesis / Q000502:physiology*; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis / Q000502:physiology; D014945:Wound Healing
chemical_list: D018786:Bone Substitutes; D042461:Vascular Endothelial Growth Factor A