title: Bleeding from the small intestine and aortic regurgitation in Noonan syndrome.
abstract: A 62-year-old man was admitted to our hospital because of melena. On admission physical examination revealed that he had typical features of Noonan syndrome (NS). Investigation via upper endoscopy with the single balloon demonstrated oozing from the small intestine. Bleeding sometimes occurs in patients with NS. We speculated that coagulation defects or vascular malformations might have been present at the first visit in this case. However, coagulation function was normal. By upper endoscopy with the single balloon we clearly revealed the angioectasia in the small intestine. This case documents the first association among NS, aortic regurgitation and angioectasia in the small intestine.
authors: Department of General Internal Medicine, Kobe University Graduate School of Medicine, Japan. ko_h.yoshino@kohnan.or.jp
authors: Hiroshi
authors: H
authors: Yoshino
authors: Yasuyo
authors: Y
authors: Okumachi
authors: Taichi
authors: T
authors: Akisaki
authors: Hisafumi
authors: H
authors: Yasuda
authors: Kenta
authors: K
authors: Hara
authors: Koichi
authors: K
authors: Yokono
authors: Hozuka
authors: H
authors: Akita
mesh_terms: D001022:Aortic Valve Insufficiency / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D001165:Arteriovenous Malformations / Q000150:complications / Q000175:diagnosis; D006470:Hemorrhage / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D007421:Intestine, Small / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009634:Noonan Syndrome / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology