title: Inhibin-α and synaptophysin immunoreactivity in synovial sarcoma with granular cell features.
abstract: We recognized immunoreactivity for the α subset of inhibin and synaptophysin in synovial sarcomas with granular cell features. Histologic findings of 90 cases of synovial sarcoma were reviewed. Two (2.2%) of the 90 cases had granular cell features, showing sheet or nested proliferation of characteristic epithelioid cells with abundant eosinophilic and granular cytoplasm, in addition to the typical spindle cell component. The 2 cases were both female (aged 86 and 76 years). The tumors were located in the foot and the retroperitoneum and measured 3.5 and 14 cm in maximum diameter. Reverse transcriptase polymerase chain reaction analysis revealed SS18-SSX1 transcripts in both cases. SS18 gene rearrangement was detected in granular cells as well as spindle cells by chromogenic in situ hybridization. Immunohistochemistry found the granular cells to be positive for inhibin-α in both cases and for synaptophysin in 1 case, whereas spindle cells were not. Thirty-six cases (20 monophasic fibrous, 11 biphasic, and 5 poorly differentiated synovial sarcomas) were additionally examined for comparison; they showed no immunoreactivity for inhibin-α or synaptophysin. This is the first report of immunoreactivity for inhibin-α and synaptophysin in synovial sarcoma. These immunohistochemical findings might be characteristic of synovial sarcomas with granular cell features.
authors: Department of Anatomic Pathology, Graduate School of Medical Science, Kyushu University, Fukuoka 812-8582, Japan.
authors: Nokitaka
authors: N
authors: Setsu
authors: Kenichi
authors: K
authors: Kohashi
authors: Makoto
authors: M
authors: Endo
authors: Hidetaka
authors: H
authors: Yamamoto
authors: Yoshihiro
authors: Y
authors: Ohishi
authors: Kazunobu
authors: K
authors: Sueyoshi
authors: Yukihide
authors: Y
authors: Iwamoto
authors: Masazumi
authors: M
authors: Tsuneyoshi
authors: Toru
authors: T
authors: Motoi
authors: Arisa
authors: A
authors: Kumagai
authors: Yoshinao
authors: Y
authors: Oda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007265:Inhibins / Q000096:biosynthesis*; D046529:Microscopy, Electron, Transmission; D012189:Retrospective Studies; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013584:Sarcoma, Synovial / Q000235:genetics / Q000378:metabolism* / Q000648:ultrastructure; D012983:Soft Tissue Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000648:ultrastructure; D016708:Synaptophysin / Q000096:biosynthesis*
chemical_list: D014408:Biomarkers, Tumor; D016708:Synaptophysin; C094377:inhibin-alpha subunit; D007265:Inhibins