title: Two cases of opportunistic parasite infections in patients receiving alemtuzumab.
abstract: Two cases are reported of rare digestive opportunistic parasites in patients being treated with alemtuzumab for lymphoid haematological malignancies. In both patients, classical biological examinations were insufficient to reach the diagnosis. Only specific parasitological techniques enabled diagnoses of cryptosporidiosis and microsporidiosis, respectively. In both cases, cellular immune reconstitution was sufficient to eradicate these opportunistic infections. In this context, parasitological diagnosis is often underestimated by medical practitioners, so immunologists and oncohaematologists need to be aware of this kind of opportunistic pathogen.
authors: Unit of Parasitology - Mycology - Tropical Medicine, CHRU Bretonneau, Tours, France. guillaume.desoubeaux@univ-tours.fr
authors: Guillaume
authors: G
authors: Desoubeaux
authors: Charline
authors: C
authors: Caumont
authors: Christophe
authors: C
authors: Passot
authors: Caroline
authors: C
authors: Dartigeas
authors: Eric
authors: E
authors: Bailly
authors: Jacques
authors: J
authors: Chandenier
authors: Thanh Haï
authors: TH
authors: Duong
mesh_terms: D000368:Aged; D000074323:Alemtuzumab; D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects*; D000912:Antibodies, Neoplasm / Q000009:adverse effects*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D003457:Cryptosporidiosis / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology / Q000469:parasitology; D003458:Cryptosporidium / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D021862:Enterocytozoon / Q000276:immunology / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D008828:Microbiological Techniques; D016881:Microsporidiosis / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology / Q000382:microbiology; D009894:Opportunistic Infections / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology / Q000382:microbiology / Q000469:parasitology
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000912:Antibodies, Neoplasm; D000970:Antineoplastic Agents; D000074323:Alemtuzumab