title: Migrating motor complex changes after side-to-side ileal bypass in mouse ileum ex-vivo: mechanism underlying the blind loop syndrome?
abstract: OBJECTIVE
  This study was intended to investigate the migrating motor complex (MMC) changes after ileal bypass in ex-vivo mouse models.
  
  
  METHODS
  Partial (side-to-side) and total bypass (occlusion of proximal part of bypassed loop) were performed on ileums of female Institute of Cancer Research mice. After 2 and 4 weeks, the bypassed segments were harvested and MMCs were recorded at 4 different sites ex-vivo. Amplitude, duration, interval, direction of propagation, and the area under the curve (AUC) of MMCs were measured and compared to those of the controls.
  
  
  RESULTS
  In control mice (n = 7), most MMCs propagated aborally (91.1%). After 2 weeks of partial bypass (n = 4), there was a significant decrease in both amplitude and AUC, and orally-propagating MMCs increased significantly (45%, P = 0.002). Bidirectional MMCs (originating in the bypassed loop and propagating in both directions) were also observed (10%). The amplitude of the MMCs remained decreased at 4 weeks after partial bypass (n = 4), and neither the AUC nor the direction of propagation showed significant changes compared to 2 weeks. Similarly, in the total bypass model, both the amplitude and AUC of the MMCs decreased significantly compared to controls. In contrast to partial bypass, 95% of the MMCs within the bypassed loop propagated aborally after 2 weeks (n = 6), which was similar to the control state. After 4 weeks (n = 5), however, MMCs either lost their temporal relationship or completely disappeared.
  
  
  CONCLUSIONS
  The changes in propagation direction of the MMCs in the partially bypassed loop may contribute to stagnation of bowel contents and the development of blind loop syndrome.
authors: Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.
authors: Suk-Bae
authors: SB
authors: Moon
authors: Kyu-Joo
authors: KJ
authors: Park
authors: Jung-Sun
authors: JS
authors: Moon
authors: Eun-Kyoung
authors: EK
authors: Choe
authors: In-Suk
authors: IS
authors: So
authors: Sung-Eun
authors: SE
authors: Jung