title: Small cell carcinoma arising from the bulbar urethra: a case report and literature review.
abstract: Primary neuroendocrine carcinomas of the genitourinary tract are rare and aggressive tumors carrying a bad prognosis. With squamous cell and transitional cell carcinoma being the most commonly reported urethral malignancies, primary small cell carcinoma (SCC) of the urethra is extremely rare. To date, only 5 cases have been reported in the literature. We present the first case of primary SCC occurring in the bulbar urethra in an 89-year-old male. We discuss the clinical, histological and immunohistochemical features of SCC of the urethra. Furthermore, we summarize the available literature and discuss the possible treatment options for this rare yet aggressive neoplasm.
authors: Department of Urology, University of Miami-Miller School of Medicine, Miami, Fla., USA. prashanth82@gmail.com
authors: Prashanth
authors: P
authors: Kanagarajah
authors: Rajinikanth
authors: R
authors: Ayyathurai
authors: Umar
authors: U
authors: Saleem
authors: Murugesan
authors: M
authors: Manoharan
mesh_terms: D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D018288:Carcinoma, Small Cell / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology*; D002945:Cisplatin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D016896:Treatment Outcome; D014521:Urethra / Q000737:chemistry / Q000473:pathology*; D014523:Urethral Neoplasms / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D005047:Etoposide; D002945:Cisplatin