title: Analysis of the effect of perioperative magnesium sulphate on minimal alveolar concentration of desflurane using bispectral index monitoring.
abstract: BACKGROUND
  In this study we aimed to analyze the effect of perioperative magnesium sulphate (MgSO(4)) on minimal alveolar concentration (MAC) of desflurane using bispectral index (BIS) monitoring.
  
  
  METHODS
  Sixty patients undergoing abdominal surgery under general anesthesia were randomized into two groups: Mg - receiving perioperative MgSO(4) supplementation and C - control. Anesthesia was titrated to maintain the BIS value between 45-55.
  
  
  RESULTS
  MAC values, tachycardia and hypertension during intubation was found to be lower in group Mg compared to group C (p<0.001). Time to extubation, verbal cooperation and eye opening was longer in patients receiving infusion of MgSO(4) (p<0.001).
  
  
  CONCLUSIONS
  We concluded that perioperative MgSO(4) infusion may be used as an adjunct as it decreases MAC of desflurane and suppresses the hemodynamic response to intubation.
authors: Department of Anesthesiology, Faculty of Medicine, Rize University, Rize, Turkey. tomakyakup@hotmail.com
authors: Yakup
authors: Y
authors: Tomak
authors: Murat
authors: M
authors: Tekin
authors: Ismail
authors: I
authors: Kati
authors: Ceyda
authors: C
authors: Belenli
authors: Meltem
authors: M
authors: Aydogmus
mesh_terms: D000293:Adolescent; D000328:Adult; D018685:Anesthetics, Inhalation / Q000032:analysis / Q000493:pharmacokinetics; D056805:Consciousness Monitors; D000077335:Desflurane; D005260:Female; D006801:Humans; D007530:Isoflurane / Q000031:analogs & derivatives* / Q000032:analysis / Q000493:pharmacokinetics; D008278:Magnesium Sulfate / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods*; D009994:Osmolar Concentration; D059035:Perioperative Period; D011650:Pulmonary Alveoli / Q000737:chemistry* / Q000378:metabolism; D013997:Time Factors; D055815:Young Adult
chemical_list: D018685:Anesthetics, Inhalation; D008278:Magnesium Sulfate; D000077335:Desflurane; D007530:Isoflurane