title: The role of lymphostatin/EHEC factor for adherence-1 in the pathogenesis of gram negative infection.
abstract: Lymphostatin/EHEC factor for adherence-1 is a novel large toxin represented in various Gram negative bacteria, highly associated with the development of infectious diarrhea and hemolytic uremic syndrome. In vitro and in vivo experiments identified lymphostatin/EFA-1 as a toxin with a central role in the pathogenesis of Gram negative bacteria, responsible for bacterial adhesion, intestinal colonization, immunosuppression, and disruption of gut epithelial barrier function.
authors: Division of Digestive Diseases, Emory University, Atlanta GA, USA. jklappr@emory.edu
authors: Jan-Michael A
authors: JM
authors: Klapproth
mesh_terms: D001422:Bacterial Adhesion; D001427:Bacterial Toxins / Q000378:metabolism*; D003967:Diarrhea / Q000382:microbiology; D054324:Enterohemorrhagic Escherichia coli / Q000378:metabolism / Q000472:pathogenicity*; D029968:Escherichia coli Proteins / Q000378:metabolism*; D006463:Hemolytic-Uremic Syndrome / Q000382:microbiology; D006801:Humans; D007165:Immunosuppression Therapy; D007422:Intestines / Q000382:microbiology
chemical_list: D001427:Bacterial Toxins; C404907:Efa1 protein, E coli; D029968:Escherichia coli Proteins; C406587:lymphostatin protein, E coli