title: When control fails: influence of the prefrontal but not striatal dopaminergic system on behavioural flexibility in a change detection task.
abstract: There is growing interest in understanding the neurobiological foundations of attention. To examine whether attentional processes in a change detection task are modulated by dopamine signalling, we investigated the influence of two polymorphisms, i.e. Val158Met (rs4680) in the catechol-O-methyl transferase (COMT) and a variable number of tandem repeats polymorphism (VNTR, rs28363170) in the dopamine transporter (DAT1). The COMT Met allele, which results in lower enzyme activity and therefore probably enhanced PFC dopamine signalling, was significantly associated with task-performance and modulated executive control: Homozygous Met/Met allele carriers had difficulties when performing a change detection task, particularly showing the greatest difficulties in case cognitive and behavioural flexibility was necessary and the required reaction was not part of the subject's primary task set. Contrary, no difference between the two genotype groups were evident, when an attentional conflict emerged and attentional control was needed for adequate responding. No association with variation in DAT1 was observed. The results indicate a dissociation of the prefrontal and striatal dopamine system for attentional control and behavioural flexibility in a change detection task: While prefrontal dopamine turnover seems to modulate performance, putatively via difficulties in set shifting leading to behavioural inflexibility in COMT Met allele carriers, striatal dopamine turnover seems less important in this regard. With respect to other studies examining mechanisms of attentional functions in different paradigms, the results suggest that behavioural flexibility and attentional control as two executive subprocesses are differentially influenced by genetic polymorphisms within the dopaminergic system. This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'.
authors: Institute for Cognitive Neuroscience, Biopsychology, Ruhr-University Bochum, Germany. Stefanie.Schulz-2@rub.de
authors: Stefanie
authors: S
authors: Schulz
authors: Larissa
authors: L
authors: Arning
authors: Marlies
authors: M
authors: Pinnow
authors: Edmund
authors: E
authors: Wascher
authors: Jörg T
authors: JT
authors: Epplen
authors: Christian
authors: C
authors: Beste
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D001288:Attention / Q000502:physiology*; D002394:Catechol O-Methyltransferase / Q000235:genetics* / Q000378:metabolism; D003071:Cognition / Q000502:physiology*; D003342:Corpus Striatum / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D018598:Minisatellite Repeats; D009483:Neuropsychological Tests; D020641:Polymorphism, Single Nucleotide; D017397:Prefrontal Cortex / Q000378:metabolism*; D011930:Reaction Time / Q000235:genetics
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D002394:Catechol O-Methyltransferase