title: Synthesis of substituted isoquinolines via Pd-catalyzed cross-coupling approaches.
abstract: Palladium complexes incorporating ligands based on a 1,3,5,7-tetramethyl-2,4,8-trioxa-6-phosphaadamantanyl scaffold were used to catalyze the arylation of ethyl cyanoacetate, malononitrile, and various ketones. The products from these reactions can be elaborated to substituted β-arylethylamines and used in microwave-assisted Pictet-Spengler reactions. The protocol developed is suitable for the synthesis of libraries of substituted isoquinolines.
authors: Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada, L8S 4M1.
authors: Nick
authors: N
authors: Todorovic
authors: Emelia
authors: E
authors: Awuah
authors: Silvia
authors: S
authors: Albu
authors: Cory
authors: C
authors: Ozimok
authors: Alfredo
authors: A
authors: Capretta