title: A novel treatment for ulcerative calcinosis cutis.
abstract: BACKGROUND
  Calcinosis cutis is a term used to describe a group of disorders which result in calcium deposits in the skin. These disorders can be separated based on etiology.
  
  
  OBJECTIVE
  Sodium thiosulfate has been used to systemically treat calciphylaxis with little to no adverse effects. We report two cases of ulcerative calcinosis cutis which were refractory to multiple topical treatments and did not improve with correction of underlying electrolyte abnormalities.
  
  
  RESULTS
  Both cases showed an excellent response to topical 25% sodium thiosulfate compounded in zinc oxide.
  
  
  CONCLUSIONS
  We are limited by a small sample size (n=2) in this case series.
  
  
  CONCLUSIONS
  We recommend topical sodium thiosulfate 25% as an alternative treatment for dystrophic calcinosis cutis.
authors: Saint Joseph Mercy Health System, Dermatology Residency Program, Ann Arbor, MI, USA. brookebair@gmail.com
authors: Brooke
authors: B
authors: Bair
authors: David
authors: D
authors: Fivenson
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D000369:Aged, 80 and over; D002114:Calcinosis / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D012871:Skin Diseases / Q000188:drug therapy* / Q000473:pathology; D013885:Thiosulfates / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D015034:Zinc Oxide / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D013885:Thiosulfates; C017717:sodium thiosulfate; D015034:Zinc Oxide