title: Iridium-catalyzed allylic fluorination of trichloroacetimidates.
abstract: A rapid allylic fluorination method utilizing trichloroacetimidates in conjunction with an iridium catalyst has been developed. The reaction is conducted at room temperature under ambient air and relies on Et(3)N·3HF reagent to provide branched allylic fluorides with complete regioselectivity. This high-yielding reaction can be conducted on a multigram scale and shows considerable functional group tolerance. The use of [(18)F]KF·Kryptofix allowed (18)F(-) incorporation in 10 min.
authors: Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.
authors: Joseph J
authors: JJ
authors: Topczewski
authors: Timothy J
authors: TJ
authors: Tewson
authors: Hien M
authors: HM
authors: Nguyen
mesh_terms: D000081:Acetamides; D000498:Allyl Compounds / Q000737:chemistry*; D002384:Catalysis; D062845:Chloroacetates; D054879:Halogenation; D007495:Iridium / Q000737:chemistry*; D013237:Stereoisomerism; D014238:Trichloroacetic Acid / Q000737:chemistry
chemical_list: D000081:Acetamides; D000498:Allyl Compounds; D062845:Chloroacetates; D007495:Iridium; D014238:Trichloroacetic Acid; C009528:trichloroacetamide