title: Robustness of fat quantification using chemical shift imaging.
abstract: The purpose of this study was to investigate the effect of parameter changes that can potentially lead to unreliable measurements in fat quantification. Chemical shift imaging was performed using spoiled gradient echo sequences with systematic variations in the following: two-dimensional/three-dimensional sequence, number of echoes, delta echo time, fractional echo factor, slice thickness, repetition time, flip angle, bandwidth, matrix size, flow compensation and field strength. Results indicated no significant (or significant but small) changes in fat fraction with parameter. The significant changes can be attributed to the known effects of T1 bias and two forms of noise bias.
authors: Department of Radiology, University of California San Diego, San Diego, CA 92103–8226, USA.
authors: Katie H
authors: KH
authors: Hansen
authors: Michael E
authors: ME
authors: Schroeder
authors: Gavin
authors: G
authors: Hamilton
authors: Claude B
authors: CB
authors: Sirlin
authors: Mark
authors: M
authors: Bydder
mesh_terms: D000273:Adipose Tissue / Q000473:pathology*; D000465:Algorithms; D005234:Fatty Liver / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique