title: SHARPINing integrin inhibition.
abstract: The activity state of integrins is crucial for cell adhesion, migration and differentiation, and is regulated predominantly by protein interactions of the integrin β cytoplasmic domain. SHARPIN is now shown to negatively regulate integrin activation by binding the α-integrin subunit and interfering with the association of the β cytodomain with activating proteins.
authors: Mark D
authors: MD
authors: Bass
mesh_terms: D000818:Animals; D006801:Humans; D019012:Integrin beta1 / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*
chemical_list: D019012:Integrin beta1; D009419:Nerve Tissue Proteins; C425287:sharpin