title: Physicochemical and toxicological properties of commercial carbon blacks modified by reaction with ozone.
abstract: Ozonation of two commercial carbon blacks (CBs), Printex 90 (P90) and Flammruss 101 (F101), was carried out and changes in their morphology, physical properties, and cytotoxicity were examined. The hypothesis examined was that different methods of manufacture of CBs influence their chemical reactivity and toxicological properties. Structural changes were examined by X-ray photoelectron spectroscopy, infrared spectroscopy, Raman spectroscopy, and electron paramagnetic resonance spectroscopy (EPR). Introduction of surface oxygen functionality upon ozonation led to changes in surface charge, aggregation characteristics, and free radical content of the CBs. However, these changes in surface functionality did not alter the cytotoxicity and release of inflammation markers upon exposure of the CBs to murine macrophages. Interaction of macrophages with F101 resulted in higher levels of inflammatory markers than P90, and the only structural correlation was with the higher persistent radical concentration on the F101.
authors: Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, United States.
authors: Brian C
authors: BC
authors: Peebles
authors: Prabir K
authors: PK
authors: Dutta
authors: W James
authors: WJ
authors: Waldman
authors: Frederick A
authors: FA
authors: Villamena
authors: Kevin
authors: K
authors: Nash
authors: Michael
authors: M
authors: Severance
authors: Amber
authors: A
authors: Nagy
mesh_terms: D000393:Air Pollutants / Q000737:chemistry / Q000633:toxicity; D000818:Animals; D002460:Cell Line; D003603:Cytotoxins / Q000737:chemistry / Q000633:toxicity*; D051379:Mice; D008956:Models, Chemical; D010126:Ozone / Q000737:chemistry*; D053260:Soot / Q000737:chemistry / Q000633:toxicity*; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
chemical_list: D000393:Air Pollutants; D003603:Cytotoxins; D053260:Soot; D010126:Ozone