title: Lack of association between polymorphisms in the prostaglandin F2α receptor and solute carrier organic anion transporter family 2A1 genes and intraocular pressure response to prostaglandin analogs.
abstract: OBJECTIVE
  To evaluate the association between variants in the prostaglandin F(α) receptor (PTGFR) and solute carrier organic anion transporter family 2A1 (SLCO2A1) genes and intraocular pressure (IOP) response to prostaglandin analogs.
  
  
  METHODS
  The medical records of subjects with previously diagnosed open angle glaucoma or ocular hypertension were searched for intraocular pressure measurements before and after prescriptions of prostaglandin analogs. Stored DNA samples were genotyped for the following SNPs: rs3753380 (promoter region) and rs3766355 (intronic region) of the prostaglandin F(2α) receptor gene, and rs34550074 (Ala396Thr) of SLCO2A1. The mean change in IOP by genotype was measured.
  
  
  RESULTS
  Prostaglandin analogs were prescribed to 267 subjects; 242 (204 right eyes, 205 left eyes) met the inclusion/exclusion criteria for the current study. There was no significant association between genotype and IOP response to prostaglandin analogs (p = 0.48, p = 0.54, p = 0.90).
  
  
  CONCLUSIONS
  In summary, we found no indication for an association between SNPs in the prostaglandin F(2α) receptor gene or SLCO2A1 and IOP response to prostaglandin analogs in a population of European descent.
authors: Marshfield Clinic Research Foundation, Marshfield, USA. cmccarty@eirh.org
authors: Catherine A
authors: CA
authors: McCarty
authors: Richard
authors: R
authors: Berg
authors: Richard
authors: R
authors: Patchett
authors: Russell A
authors: RA
authors: Wilke
authors: James K
authors: JK
authors: Burmester
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D005838:Genotype; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000235:genetics*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D000077338:Latanoprost; D009798:Ocular Hypertension; D027361:Organic Anion Transporters / Q000235:genetics*; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide; D011461:Prostaglandins F, Synthetic / Q000627:therapeutic use*; D011982:Receptors, Prostaglandin / Q000235:genetics*
chemical_list: D000959:Antihypertensive Agents; D027361:Organic Anion Transporters; D011461:Prostaglandins F, Synthetic; D011982:Receptors, Prostaglandin; C503526:SLCO2A1 protein, human; C034671:prostaglandin F2alpha receptor; D000077338:Latanoprost