title: [Antimicrobial activity of some cinnamic acid derivatives].
abstract: Due to drug-resistance phenomenon, there is a constant need for discovering new antiinfectious agents. A series of cinnamic acid derivatives was synthesized and then brominated with bromine in the presence of chloroform or acetic acid. The structure of the new compounds was confirmed by elemental and spectral data. Their antimicrobial activity was tested by disc-diffusion method. The tested compounds had mainly antifungal activity and were moderately active against Gram-positive bacteria. Bromination of the double bond determined the enhancement of the antimicrobial activity for all the tested compounds.
authors: Universitatea de Medicină şi Farmacie "Gr. T. Popa" Iaşi, Facultatea de Farmacie, Disciplina de Chimie Organică.
authors: Alexandra
authors: A
authors: Jităreanu
authors: Gabriela
authors: G
authors: Tătărîngă
authors: Ana-Maria
authors: AM
authors: Zbancioc
authors: Cristina
authors: C
authors: Tuchiluş
authors: Ursula
authors: U
authors: Stănescu
mesh_terms: D019342:Acetic Acid / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D001966:Bromine / Q000737:chemistry; D002725:Chloroform / Q000737:chemistry; D002934:Cinnamates / Q000138:chemical synthesis* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005658:Fungi / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D002934:Cinnamates; C029010:cinnamic acid; D002725:Chloroform; D019342:Acetic Acid; D001966:Bromine