title: Catalytic enantioselective addition of terminal 1,3-diynes to aromatic ketones: facile access to chiral nonracemic tertiary alcohols.
abstract: An efficient, catalytic, and enantioselective 1,2-addition of terminal 1,3-diynes to aromatic ketones was realized in the presence of 10 mol% of a Cu(OTf)(2)-hydroxycamphor-sulfonamide complex, affording chiral tertiary alcohols in up to 94% yield and 90% ee.
authors: Department of Chemistry, Tianjin University, Tianjin 300072, China.
authors: Tian-Lin
authors: TL
authors: Liu
authors: Hai
authors: H
authors: Ma
authors: Fa-Guang
authors: FG
authors: Zhang
authors: Yan
authors: Y
authors: Zheng
authors: Jing
authors: J
authors: Nie
authors: Jun-An
authors: JA
authors: Ma
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D002384:Catalysis; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D018360:Crystallography, X-Ray; D053280:Diynes / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008968:Molecular Conformation; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D056831:Coordination Complexes; D053280:Diynes; D007659:Ketones; D003300:Copper