title: On the origin of the triplet puzzle of homologies in receptor heteromers: Toll-like receptor triplets in different types of receptors.
abstract: Based on our theory, we have discovered main triplets of amino acid residues in the GABAB1 receptor and several other neural receptors, which seem to originate from toll-like receptors and appear also as homologies in receptor heteromers. The obtained results strengthen our hypothesis that these triplets may 'guide-and-clasp' receptor-receptor interactions.
authors: St. Petersburg Institute for Informatics and Automation, Russian Academy of Sciences, Saint Petersburg, Russia. tar@iias.spb.su
authors: Alexander O
authors: AO
authors: Tarakanov
authors: Kjell G
authors: KG
authors: Fuxe
authors: Dasiel O
authors: DO
authors: Borroto-Escuela
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008969:Molecular Sequence Data; D021122:Protein Subunits / Q000737:chemistry / Q000235:genetics; D020794:Receptor Protein-Tyrosine Kinases / Q000737:chemistry / Q000235:genetics; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry / Q000235:genetics; D011963:Receptors, GABA-A / Q000737:chemistry / Q000235:genetics; D017981:Receptors, Neurotransmitter / Q000737:chemistry* / Q000235:genetics; D015398:Signal Transduction / Q000502:physiology; D051193:Toll-Like Receptors / Q000737:chemistry* / Q000235:genetics
chemical_list: C546264:GABRB1 protein, human; D021122:Protein Subunits; D043562:Receptors, G-Protein-Coupled; D011963:Receptors, GABA-A; D017981:Receptors, Neurotransmitter; D051193:Toll-Like Receptors; D020794:Receptor Protein-Tyrosine Kinases