title: The future of adult cardiac assist devices: novel systems and mechanical circulatory support strategies.
abstract: The recent, widespread success of mechanical circulatory support has prompted the development of numerous implantable devices to treat advanced heart failure. It is important to raise awareness of novel device systems, the mechanisms by which they function, and implications for patient management. This article discusses devices that are being developed or are in clinical trials. Devices are categorized as standard full support, less-invasive full support, partial support: rotary pumps, partial support: counterpulsation devices, right ventricular assist device, and total artificial heart. Implantation strategy, mechanism of action, durability, efficacy, hemocompatibility, and human factors are considered. The feasibility of novel strategies for unloading the failing heart is examined.
authors: Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, KY, USA.
authors: Carlo R
authors: CR
authors: Bartoli
authors: Robert D
authors: RD
authors: Dowling
mesh_terms: D000328:Adult; D015908:Counterpulsation / Q000295:instrumentation / Q000639:trends; D005544:Forecasting; D006333:Heart Failure / Q000628:therapy*; D006354:Heart, Artificial / Q000639:trends; D006353:Heart-Assist Devices / Q000639:trends*; D006801:Humans; D011474:Prosthesis Design / Q000639:trends*; D019919:Prosthesis Implantation / Q000379:methods