title: [Research advance of the protective role of PACAP in the nervous system diseases].
abstract: In the central nervous system, pituitary adenylate cyclase-activating polypeptide (PACAP) exerts different actions as neurotransmitter, neuromodulator, neurotrophic and neuroprotective factors via multiple signaling pathways. PACAP plays an important protective role in the nervous system diseases, such as focal cerebral ischemia, traumatic brain injury (TBI), schizophrenia, anxiety disorders Parkinson's disease and Alzheimer's disease. Now, we reviewed the research advances about the protective role of PACAP in the nervous system diseases.
authors: Department of Anesthesia Physiology, Xuzhou Medical College Jiangsu Key Laboratory of Oresthesiology, Xuzhou 221004, China.
authors: Shan-shan
authors: SS
authors: Mao
authors: Yong-mei
authors: YM
authors: Zhang
mesh_terms: D000544:Alzheimer Disease / Q000503:physiopathology / Q000517:prevention & control; D000818:Animals; D001930:Brain Injuries / Q000503:physiopathology / Q000517:prevention & control; D006801:Humans; D009422:Nervous System Diseases / Q000503:physiopathology*; D018696:Neuroprotective Agents; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide / Q000502:physiology*; D020521:Stroke / Q000503:physiopathology / Q000517:prevention & control
chemical_list: D018696:Neuroprotective Agents; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide