title: Single negative colposcopy: is it enough to rule out high-grade disease?
abstract: It has been proposed that women who have a negative colposcopic examination or who have no cervical intraepithelial neoplasia (CIN) on colposcopic biopsy can be safely returned to routine screening with the next visit being three or five years later. We present data regarding 551 women who had colposcopy in Wales for a low-grade cytological abnormality and who were followed through Cervical Screening Wales for subsequent CIN. Of 436 women declared CIN free initially, 26 (6.0%) had high-grade CIN diagnosed on follow-up. We suggest that additional screening at an interval of less than three years should be offered to women with a negative colposcopy or a biopsy without CIN.
authors: Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary's School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, UK.
authors: David
authors: D
authors: Mesher
authors: Amanda
authors: A
authors: Tristram
authors: Alejandra
authors: A
authors: Castanon
authors: Helen
authors: H
authors: Beer
authors: Suzanne
authors: S
authors: Ashman
authors: Hilary
authors: H
authors: Fielder
authors: Alison
authors: A
authors: Fiander
authors: Peter
authors: P
authors: Sasieni
mesh_terms: D000465:Algorithms; D001706:Biopsy; D003127:Colposcopy / Q000379:methods*; D003937:Diagnosis, Differential; D055088:Early Detection of Cancer / Q000379:methods; D005188:False Negative Reactions; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D060787:Neoplasm Grading; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000473:pathology