title: Preliminary findings regarding proinflammatory markers and brain-derived neurotrophic factor among adolescents with bipolar spectrum disorders.
abstract: Mood symptoms in adult bipolar disorder are associated with increased proinflammatory markers and decreased brain-derived neurotrophic factor (BDNF). We examined serum interleukin-6, high-sensitivity C-reactive protein (hsCRP), and BDNF among 30 bipolar disorder adolescents. Hypomanic/manic symptoms were positively associated with hsCRP. BDNF levels were negatively associated with interleukin-6. Forty percent had cardiovascular high-risk hsCRP levels. Larger longitudinal studies are warranted.
authors: Department of Psychiatry, Sunnybrook Health Sciences Centre, Faculty of Medicine, University of Toronto, Toronto, Canada. benjamin.goldstein@sunnybrook.ca
authors: Benjamin I
authors: BI
authors: Goldstein
authors: Katelyn A
authors: KA
authors: Collinger
authors: Francis
authors: F
authors: Lotrich
authors: Anna L
authors: AL
authors: Marsland
authors: Mary-Kay
authors: MK
authors: Gill
authors: David A
authors: DA
authors: Axelson
authors: Boris
authors: B
authors: Birmaher
mesh_terms: D000293:Adolescent; D015415:Biomarkers; D001714:Bipolar Disorder / Q000097:blood*; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis*; D002648:Child; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male
chemical_list: D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; D015850:Interleukin-6; D002097:C-Reactive Protein