title: Polymerized human placenta hemoglobin given before ischemia protects rat heart from ischemia reperfusion injury.
abstract: This study was to investigate whether polymerized human placenta hemoglobin (PolyPHb) given before ischemia protects in vivo rat heart function against ischemia/reperfusion (I/R) injury. Forty-five male Sprague-Dawley rats were randomly divided (n = 15 per group) into a sham group, control group (pretreatment with Lactated Ringer's solution), or PolyPHb group (pretreatment with 0.1 gHb/kg PolyPHb). Rat hearts were subjected to 30-min ischemia by occlusion of left anterior descending, followed by 2-hr reperfusion. As compared to the control group, PolyPHb preserved cardiac function and reduced cardiac troponin-I release and histopathological changes. Therefore, PolyPHb pretreatment provided a profound cardioprotective effect on the in vivo rat heart.
authors: Laboratory of Anesthesiology and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China. scutaoli1981@gmail.com
authors: Tao
authors: T
authors: Li
authors: Ronghua
authors: R
authors: Zhou
authors: Xujin
authors: X
authors: Xiang
authors: Da
authors: D
authors: Zhu
authors: Yanyan
authors: Y
authors: Li
authors: Jin
authors: J
authors: Liu
authors: Wei
authors: W
authors: Wu
authors: Chengmin
authors: C
authors: Yang
mesh_terms: D000818:Animals; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D006352:Heart Ventricles / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D006454:Hemoglobins / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D055503:Protein Multimerization; D020836:Protein Structure, Quaternary; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D019210:Troponin I / Q000378:metabolism
chemical_list: D006454:Hemoglobins; D019210:Troponin I