title: Environmental enrichment can prevent cognitive decline induced by dietary oxidative challenge.
abstract: Alzheimer's disease encompasses multiple risk factors; convergence may be necessary for clinical manifestation. Mice received a complete diet or one lacking folate and vitamin E and containing iron as a pro-oxidant, in a standard environment (SE) or a large cage containing objects to stimulate exploration/activity (enriched environment; EE). Mice declined in maze navigation on the deficient versus complete diet in the SE but not the EE. Mice on the complete diet demonstrated superior performance in the EE versus SE. The EE reduced brain lipid and protein oxidation. These findings suggest that maintaining nutrition and activity may delay age-related cognitive decline.
authors: Center for Cellular Neurobiology and Neurodegeneration Research, Department of Biological Sciences, University of Massachusetts Lowell, Lowell, MA 01854, USA.
authors: Sangmook
authors: S
authors: Lee
authors: Vanessa
authors: V
authors: Doulames
authors: Michelle
authors: M
authors: Donnelly
authors: James
authors: J
authors: Levasseaur
authors: Thomas B
authors: TB
authors: Shea
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D003072:Cognition Disorders / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control*; D019587:Dietary Supplements; D004195:Disease Models, Animal; D004777:Environment; D005260:Female; D005494:Folic Acid Deficiency / Q000150:complications*; D008297:Male; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018384:Oxidative Stress / Q000502:physiology; D050050:Protein Carbonylation; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014811:Vitamin E Deficiency / Q000150:complications*
chemical_list: D017392:Thiobarbituric Acid Reactive Substances