title: A method for the reductive scission of heterocyclic thioethers.
abstract: A mild, chemoselective, and generally high-yielding method for the reductive scission of heterocyclic thioethers is described. Suitable heterocycles have a thioether substituent at the 2-position relative to a ring heteroatom. The convenient and straightforward method is demonstrated with reactants which are not compatible with the standard Raney nickel conditions such as sulfides, sulfones, and thiophenes. In addition, benzyl esters, benzyl amides, and benzyl carbamates are tolerated by the reductive reaction conditions.
authors: Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065-0900, USA. thomas.graham@merck.com
authors: Thomas H
authors: TH
authors: Graham
authors: Wensheng
authors: W
authors: Liu
authors: Dong-Ming
authors: DM
authors: Shen
mesh_terms: D020650:Combinatorial Chemistry Techniques; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D013440:Sulfides / Q000737:chemistry*
chemical_list: D006571:Heterocyclic Compounds; D013440:Sulfides