title: [Molecular genetics of globozoospermia: an update].
abstract: Globozoospermia, as a severe teratozoospermia caused by gene mutations, is a rare congenital disease with main clinical manifestations of the round head of sperm and abnormality or absence of acrosome, and its precise mechanism is not yet clear. Studies show that the pathogenic genes associated with globozoospermia include SPATA16, PICK1, GOPC, Hrb, Csnk2a2 and bs. This paper outlines the progress in the studies of molecular genetics of globozoospermia, aiming to contribute to the molecular diagnosis and mechanism investigation of the disease.
authors: PLA Research Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China. wanlei890309@sina.com
authors: Lei
authors: L
authors: Wan
authors: Li-mei
authors: LM
authors: An
authors: Xin-yi
authors: XY
authors: Xia
mesh_terms: D000177:Acrosome; D006801:Humans; D007248:Infertility, Male / Q000235:genetics* / Q000473:pathology; D008297:Male; D009154:Mutation; D013094:Spermatozoa / Q000002:abnormalities*