title: Identification of Acvr2a as a Th17 cell-specific gene induced during Th17 differentiation.
abstract: IL-17-producing T lymphocytes have been found to comprise a distinct lineage of T helper cells (Th17 cells) that are major causes of autoimmune diseases such as EAE, RA, and IBD. In this study, we found that activin receptor type-2A (Acvr2a) is a gene induced during the differentiation of this effector cell lineage as compared with naïve T cells. The transcript of Acvr2a was not induced in Th1 and Th2 cells, and both TGF-β and IL-6 were required for the induction of Acvr2a. When the differentiation of Th17 cells was inhibited by all tarans retinoic acid (ATRA) which induces regulatory T cell (Treg) differentiation under Th17 differentiation conditions, expression of Acvr2a was also inhibited. Hence we propose that Acvr2a is a Th17 specific gene making Th17 cells distinct from other helper T cells, Th1, Th2, and Treg.
authors: Division of Applied Life Science, PMBBRC, Gyeongsang National University, Jinju, Republic of Korea.
authors: Hyun-Ju
authors: HJ
authors: Ihn
authors: Dong Hyeok
authors: DH
authors: Kim
authors: Sang-Seok
authors: SS
authors: Oh
authors: Chaerin
authors: C
authors: Moon
authors: Jin Woong
authors: JW
authors: Chung
authors: Hyunkeun
authors: H
authors: Song
authors: Kwang Dong
authors: KD
authors: Kim
mesh_terms: D030301:Activin Receptors, Type II / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D005260:Female; D005786:Gene Expression Regulation; D015850:Interleukin-6 / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D018417:Th1 Cells / Q000378:metabolism; D058504:Th17 Cells / Q000276:immunology / Q000378:metabolism*; D018418:Th2 Cells / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D014212:Tretinoin / Q000494:pharmacology*
chemical_list: D015850:Interleukin-6; D016212:Transforming Growth Factor beta; D014212:Tretinoin; D030301:Activin Receptors, Type II; C425585:activin receptor type II-A