title: Balance between macronutrients affects life span and functional senescence in fruit fly Drosophila melanogaster.
abstract: It has recently been demonstrated that as the ratio of protein to carbohydrate (P:C) in the diet declines, life span increases in Drosophila. Here we explored how extremely low dietary ratios of protein to carbohydrate affected longevity and a selection of variables associated with functional senescence. An increase in P:C ratio from 1:57 to 1:20 shortened life span by increasing age-dependent mortality; whereas a further decline in P:C from 1:57 to 1:95 caused a modest decrease in life span. Female flies consuming the 1:20 and 1:38 diets laid more eggs than those consuming the lower P:C diets. Flies fed diets with higher ratios were more resistant to heat stress. Flies consuming the diets with lowest P:C ratios needed more time to restore activity after paralysis. Our study has therefore extended to very low P:C ratios available data demonstrating that dietary P:C ratio affects life span, fecundity and heat stress resistance, with fecundity and heat stress responses showing the opposite trend to life span.
authors: Department of Biochemistry and Biotechnology, Vassyl Stefanyk Precarpathian National University, Ivano-Frankivsk 76025, Ukraine. olehl@pu.if.ua
authors: Oleh V
authors: OV
authors: Lushchak
authors: Dmytro V
authors: DV
authors: Gospodaryov
authors: Bohdana M
authors: BM
authors: Rovenko
authors: Andriy D
authors: AD
authors: Glovyak
authors: Ihor S
authors: IS
authors: Yurkevych
authors: Vira P
authors: VP
authors: Klyuba
authors: Maria V
authors: MV
authors: Shcherbij
authors: Volodymyr I
authors: VI
authors: Lushchak
mesh_terms: D000375:Aging; D000818:Animals; D002241:Carbohydrates / Q000494:pharmacology*; D004331:Drosophila melanogaster / Q000254:growth & development*; D005260:Female; D005298:Fertility / Q000502:physiology; D008018:Life Cycle Stages / Q000502:physiology*; D008136:Longevity / Q000187:drug effects* / Q000502:physiology; D008297:Male; D011506:Proteins / Q000494:pharmacology*
chemical_list: D002241:Carbohydrates; D011506:Proteins