title: Copper-releasing, boron-containing bioactive glass-based scaffolds coated with alginate for bone tissue engineering.
abstract: The aim of this study was to synthesize and characterize new boron-containing bioactive glass-based scaffolds coated with alginate cross-linked with copper ions. A recently developed bioactive glass powder with nominal composition (wt.%) 65 SiO2, 15 CaO, 18.4 Na2O, 0.1 MgO and 1.5 B2O3 was fabricated as porous scaffolds by the foam replica method. Scaffolds were alginate coated by dipping them in alginate solution. Scanning electron microscopy investigations indicated that the alginate effectively attached on the surface of the three-dimensional scaffolds leading to a homogeneous coating. It was confirmed that the scaffold structure remained amorphous after the sintering process and that the alginate coating improved the scaffold bioactivity and mechanical properties. Copper release studies showed that the alginate-coated scaffolds allowed controlled release of copper ions. The novel copper-releasing composite scaffolds represent promising candidates for bone regeneration.
authors: Department of Chemical Engineering, Chemical and Metallurgical Engineering Faculty, Istanbul Technical University, Maslak 34469, Istanbul, Turkey.
authors: M M
authors: MM
authors: Erol
authors: V
authors: V
authors: Mouriňo
authors: P
authors: P
authors: Newby
authors: X
authors: X
authors: Chatzistavrou
authors: J A
authors: JA
authors: Roether
authors: L
authors: L
authors: Hupa
authors: Aldo R
authors: AR
authors: Boccaccini
mesh_terms: D000042:Absorption / Q000187:drug effects; D000464:Alginates / Q000494:pharmacology; D001842:Bone and Bones / Q000187:drug effects*; D001895:Boron / Q000737:chemistry*; D002516:Ceramics / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D019245:Compressive Strength / Q000187:drug effects; D003300:Copper / Q000737:chemistry*; D004055:Differential Thermal Analysis; D005898:Glass / Q000737:chemistry*; D020723:Glucuronic Acid / Q000494:pharmacology; D006603:Hexuronic Acids / Q000494:pharmacology; D006358:Hot Temperature; D007477:Ions; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D016062:Porosity / Q000187:drug effects; D017550:Spectroscopy, Fourier Transform Infrared; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D000464:Alginates; D020099:Coated Materials, Biocompatible; D006603:Hexuronic Acids; D007477:Ions; C425330:bioactive glass 45S5; D014867:Water; D003300:Copper; D020723:Glucuronic Acid; D001895:Boron