title: CD20 expression has no prognostic role in Philadelphia-negative B-precursor acute lymphoblastic leukemia: new insights from the molecular study of minimal residual disease.
abstract: The prognostic significance of CD20 expression in acute lymphoblastic leukemia has been investigated in children and adults but is still a subject of debate. The aim of our study was to correlate CD20 expression with clinical-biological characteristics and outcome in 172 Philadelphia chromosome negative patients prospectively treated in a multicenter trial introducing the molecular evaluation of minimal residual disease for therapeutic purposes. We considered 20% as the threshold for CD20 positivity. Complete remission rate, minimal residual disease negativity rate at weeks 10, 16 and 22, and disease-free and overall survival were similar among CD20-positive and -negative patients, even considering minimal residual disease results and related therapeutic choices. Our study failed to demonstrate any prognostic significance for CD20 expression in Philadelphia chromosome negative acute lymphoblastic leukemia. This conclusion is supported for the first time by a comparable minimal residual disease response rate among CD20-positive and -negative and positive patients.
authors: Unità Funzionale di Ematologia, Università degli Studi, Azienda Ospedaliero-Universitaria Careggi, Firenze , Italy. mannelli.francesco@libero.it
authors: Francesco
authors: F
authors: Mannelli
authors: Giacomo
authors: G
authors: Gianfaldoni
authors: Tamara
authors: T
authors: Intermesoli
authors: Chiara
authors: C
authors: Cattaneo
authors: Erika
authors: E
authors: Borlenghi
authors: Sergio
authors: S
authors: Cortelazzo
authors: Irene
authors: I
authors: Cavattoni
authors: Enrico Maria
authors: EM
authors: Pogliani
authors: Monica
authors: M
authors: Fumagalli
authors: Emanuele
authors: E
authors: Angelucci
authors: Claudio
authors: C
authors: Romani
authors: Fabio
authors: F
authors: Ciceri
authors: Consuelo
authors: C
authors: Corti
authors: Anna
authors: A
authors: Scattolin
authors: Agostino
authors: A
authors: Cortelezzi
authors: Daniele
authors: D
authors: Mattei
authors: Ernesta
authors: E
authors: Audisio
authors: Orietta
authors: O
authors: Spinelli
authors: Elena
authors: E
authors: Oldani
authors: Alberto
authors: A
authors: Bosi
authors: Alessandro
authors: A
authors: Rambaldi
authors: Renato
authors: R
authors: Bassan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018951:Antigens, CD20 / Q000235:genetics*; D015870:Gene Expression; D006801:Humans; D008875:Middle Aged; D018365:Neoplasm, Residual; D010677:Philadelphia Chromosome; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000401:mortality / Q000628:therapy; D016019:Survival Analysis; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D018951:Antigens, CD20