title: Voriconazole serum levels measured by high-performance liquid chromatography: a monocentric study in treated patients.
abstract: In this study we present the results of a therapeutic drug monitoring retrospective analysis involving 14 patients with several underlying diseases who were receiving voriconazole for the treatment of fungal infections. A simple high performance liquid chromatography assay with ultraviolet detection was used in the drug monitoring. We report here that serum concentrations were highly variable and unpredictable in most patients. We also found that lack of response was more frequent in patients with levels persistently lower than 1 mg/l. The number of samples with voriconazole concentrations below 1 mg/l was significantly higher in patients who exhibited therapeutic failures (88% versus 27%; P < 0.001). In addition, the period of time in which voriconazole concentrations were maintained below 1 mg/l was slightly higher in patients in the failure group. We suggest that serum concentration should be individually quantified for patients receiving voriconazole therapy. Further prospective studies are needed to clarify the potential benefit of the individualization of treatment.
authors: Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain. aliciagl@isciii.es
authors: Alicia
authors: A
authors: Gómez-López
authors: Emilio
authors: E
authors: Cendejas-Bueno
authors: Isabel
authors: I
authors: Cuesta
authors: Julio
authors: J
authors: García Rodríguez
authors: Juan L
authors: JL
authors: Rodríguez-Tudela
authors: A
authors: A
authors: Gutiérrez-Altés
authors: Manuel
authors: M
authors: Cuenca-Estrella
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy; D011743:Pyrimidines / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D012189:Retrospective Studies; D044967:Serum / Q000737:chemistry*; D013997:Time Factors; D014230:Triazoles / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D065819:Voriconazole; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole