title: Risk factors for progression from cytomegalovirus viremia to cytomegalovirus disease after allogeneic hematopoietic stem cell transplantation.
abstract: Cytomegalovirus (CMV) disease is a major cause of infectious complications in allogeneic hematopoietic stem cell transplantation (allo-HSCT). Although patients undergoing allo-HSCT receive prophylactic and preemptive treatment for CMV, a subset of patients experience clinically significant CMV disease. This study investigated the risk factors for progression from CMV viremia to CMV disease during or after preemptive therapy in patients undergoing allo-HSCT. Between January 2006 and August 2010, 43 patients received preemptive therapy for CMV viremia after allo-HSCT. These patients experienced 74 episodes of CMV viremia. Nine of the patients (21%) and 12 of the episodes (16%) progressed to CMV disease. Univariate analysis identified several risk factors for progression to CMV disease, including high initial viral load (P = .020), leukopenia (P = .012), and neutropenia (P = .033) at the time of detection of CMV viremia. On multivariate analysis, leukopenia remained an independent predictor (hazard ratio, 4.347; P = .045). The rate of failure to clear CMV viremia after 1 cycle of preemptive therapy was higher in the leukopenia group than in the non-leukopenia group (60.0% versus 16.9%; P = .002). This indicates that leukopenia initially documented with CMV viremia is related to lower viral response to preemptive therapy and is a notable risk factor for progression from CMV viremia to CMV disease.
authors: Division of Hematology, Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Republic of Korea.
authors: Ji Eun
authors: JE
authors: Jang
authors: Shin Young
authors: SY
authors: Hyun
authors: Yun Deok
authors: YD
authors: Kim
authors: Sul Hee
authors: SH
authors: Yoon
authors: Doh Yu
authors: DY
authors: Hwang
authors: Soo Jeong
authors: SJ
authors: Kim
authors: Yuri
authors: Y
authors: Kim
authors: Jin Seok
authors: JS
authors: Kim
authors: June-Won
authors: JW
authors: Cheong
authors: Yoo Hong
authors: YH
authors: Min
mesh_terms: D000293:Adolescent; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage*; D003587:Cytomegalovirus / Q000187:drug effects / Q000502:physiology; D003586:Cytomegalovirus Infections / Q000150:complications / Q000517:prevention & control* / Q000821:virology; D018450:Disease Progression; D004334:Drug Administration Schedule; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007970:Leukopenia / Q000150:complications / Q000821:virology; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000150:complications / Q000821:virology; D056910:Republic of Korea; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous; D014766:Viremia / Q000150:complications / Q000517:prevention & control* / Q000821:virology
chemical_list: D000998:Antiviral Agents