title: Characterization of a murine lung adenocarcinoma (LAC1), a useful experimental model to study progression of lung cancer.
abstract: Lung cancer is one of the most important avoidable causes of death around the world, the most widespread carcinoma, with a very poor prognosis, and is the leading cause of cancer death in both developed and developing countries. We report morphological and biological behavior characteristics of a tumor that arose in only one BALB/c mouse of an experimental group treated with urethane, a chemical lung-tumorigenic agent. Morphological and immunochemical analysis indicated phenotypic compatibility with a lung adenocarcinoma. The tumor was named LAC1 (lung adenocarcinoma 1). Implant success in eight LAC1-bearing mice generations was 100%, with a fast evolution (58 survival days) and good metastatic capacity (41% of animals with metastases). The tumor induced a paraneoplastic syndrome characterized by anemia, neutrophilia, cachexia, splenomegaly and thymic atrophy. The lymphoproliferation to Con A was altered in tumor-bearing mice. This lung adenocarcinoma may be a useful experimental model for studying tumor progression, paraneoplastic syndromes and immunology in carcinogenic studies.
authors: Instituto de Biología Celular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, CP5000, Ciudad Universitaria, Córdoba, Argentina.
authors: Mariana
authors: M
authors: Piegari
authors: Susana
authors: S
authors: Ortiz
authors: Maria del Pilar
authors: Mdel P
authors: Díaz
authors: Aldo R
authors: AR
authors: Eynard
authors: Mirta A
authors: MA
authors: Valentich
mesh_terms: D000230:Adenocarcinoma / Q000139:chemically induced / Q000150:complications / Q000473:pathology* / Q000648:ultrastructure; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D004906:Erythrocyte Count; D006400:Hematocrit; D007150:Immunohistochemistry; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D008175:Lung Neoplasms / Q000139:chemically induced / Q000150:complications / Q000473:pathology* / Q000648:ultrastructure; D051379:Mice; D008807:Mice, Inbred BALB C; D023421:Models, Animal; D009368:Neoplasm Transplantation; D009503:Neutropenia / Q000150:complications; D009929:Organ Size; D013163:Splenomegaly / Q000150:complications / Q000473:pathology; D013950:Thymus Gland / Q000473:pathology*; D014520:Urethane
chemical_list: D003208:Concanavalin A; D014520:Urethane