title: Coupling of the mechanotransduction machinery and F-actin polymerization in the cochlear hair bundles.
abstract: Mechanoelectrical transduction (MET), the conversion of mechanical stimuli into electrical signals operated by the sensory cells of the inner ear, enables hearing and balance perception. Crucial to this process are the tip-links, oblique fibrous filaments that interconnect the actin-filled stereocilia of different rows within the hair bundle, and mechanically gate MET channels. In a recent study, we observed a complete regression of stereocilia from the short and medium but not the tall row upon the disappearance of the tip-links caused by the loss of one of their components, cadherin-23, or of one of their anchoring proteins, sans, in the auditory organs of engineered mutant mice. This indicates the existence of a coupling between the MET and F-actin polymerization machineries at the tips of the short and medium stereocilia rows in cochlear hair bundles. Here, we first present our findings in the mutant mice, and then discuss the possible effects of the tip-link tension on stereocilia F-actin polymerization, acting either directly or through Ca(2+)-dependent mechanisms that involve the gating of MET channels.
authors: Unité de Génétique et Physiologie de l'Audition; Inserm UMRS587-Université Paris VI; Institut Pasteur; Paris, France.
authors: Elisa
authors: E
authors: Caberlotto
authors: Vincent
authors: V
authors: Michel
authors: Jacques Boutet
authors: JB
authors: de Monvel
authors: Christine
authors: C
authors: Petit