title: Epidermolytic hyperkeratosis: a follow-up of 23 years of use of systemic retinoids.
abstract: Epidermolytic hyperkeratosis is a form of ichthyosis normally resistant to topical treatments. Female patient monitored since 1978 diagnosed with epidermolytic hyperkeratosis. Clinical examination showed generalized hyperkeratosis and scaling. Given that no other treatments were available at the time, the patient was initially treated with keratolytic, systemic vitamin A and moisturizers, with no improvement. In 1986, with the development of oral retinoids, etretinate was introduced. In 1998 this was replaced by acitretin. The patient is receiving 25 mg/day after 23 years of using oral retinoids. Significant improvement of the condition and patient's quality of life has been noted.
authors: Uninga Faculty, Maringa, Parana, Brazil. priwolf@gmail.com
authors: Priscila Wolf
authors: PW
authors: Nassif
authors: Sadamitsu
authors: S
authors: Nakandakari
authors: Letícia
authors: L
authors: Fogagnolo
authors: Letícia Arsie
authors: LA
authors: Contin
authors: Cinthia Janine Meira
authors: CJ
authors: Alves
mesh_terms: D017255:Acitretin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D017488:Hyperkeratosis, Epidermolytic / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D012176:Retinoids / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D012176:Retinoids; D017255:Acitretin