title: BMP action in the pituitary: its possible role in modulating somatostatin sensitivity in pituitary tumor cells.
abstract: The existence of a functional bone morphogenetic protein (BMP) system in the pituitary has been recognized. Recent studies have provided evidence that BMPs elicit differential actions in the regulation of prolactin (PRL) and adrenocorticotropin (ACTH) release in lactotropinoma and corticotropinoma cells, respectively. BMPs play a key role in the modulation of somatostatin receptor (SSTR) sensitivity of lactosomatotrope cells in an autocrine/paracrine manner. In addition, SSTR action enhances BMP responsiveness in corticotrope cells. The functional link between BMP receptor signaling and SSTR actions may be crucial for individual tolerance to somatostatin analogs for controlling PRL and ACTH production. Adjustment of the endogenous SSTR sensitivity may be an effective strategy to inhibit the growth activity and hormonal productivity of intractable pituitary tumors.
authors: Endocrine Center of Okayama University Hospital and Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, Okayama 700-8558, Japan. fumiotsu@md.okayama-u.ac.jp
authors: Fumio
authors: F
authors: Otsuka
authors: Naoko
authors: N
authors: Tsukamoto
authors: Tomoko
authors: T
authors: Miyoshi
authors: Yasumasa
authors: Y
authors: Iwasaki
authors: Hirofumi
authors: H
authors: Makino
mesh_terms: D000236:Adenoma / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D019898:Autocrine Communication; D019485:Bone Morphogenetic Proteins / Q000502:physiology*; D052680:Corticotrophs / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D052682:Lactotrophs / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D019899:Paracrine Communication; D010911:Pituitary Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D011388:Prolactin / Q000378:metabolism; D017481:Receptors, Somatostatin / Q000378:metabolism; D015398:Signal Transduction; D013004:Somatostatin / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology
chemical_list: D019485:Bone Morphogenetic Proteins; D017481:Receptors, Somatostatin; D013004:Somatostatin; D000324:Adrenocorticotropic Hormone; D011388:Prolactin