title: Cystic and non-cystic fibrosis Pseudomonas aeruginosa isolates are not differentiated by the quorum-sensing signaling and biofilm production.
abstract: The capability for biofilm and quorum-sensing (QS) signaling production among Pseudomonas aeruginosa isolates were evaluated. A total of 231 isolates were recovered from sputa of cystic fibrosis (CF, n = 104) and non-CF (non-CF, n = 127) patients. One hundred ninety-seven (85.3%; 95% CI 80.1-89.3%) were biofilm producers and 157 (68%; 95% CI 61.7-73.6%) were weak QS-producing. No difference was observed between CF and non-CF isolates regarding the ability to produce biofilm and QS-signaling. Interestingly, the degree of QS production appears to be related to the degree of biofilm production. Thus, blocking QS pathways may be crucial in the prevention and treatment of biofilm-related infections.
authors: Pharmaceutical Sciences, Faculdade de Farmácia, UFRGS, Porto Alegre, Brazil. leandro.reus@gmail.com
authors: Leandro Reus Rodrigues
authors: LR
authors: Perez
authors: Ana Lúcia Peixoto
authors: AL
authors: de Freitas
authors: Afonso Luís
authors: AL
authors: Barth
mesh_terms: D018441:Biofilms; D003550:Cystic Fibrosis / Q000382:microbiology*; D006801:Humans; D011552:Pseudomonas Infections / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000145:classification / Q000302:isolation & purification* / Q000502:physiology*; D053038:Quorum Sensing; D015398:Signal Transduction; D013183:Sputum / Q000382:microbiology