title: Investigation of the configurational stabilities of chiral isocyanoacetates in multicomponent reactions.
abstract: Isocyanoacetates are uniquely reactive compounds characterized by an ambivalent isocyano functional group and an enolizable α-carbon. It is widely believed that chiral α-substituted isocyanoacetates are configurationally unstable in some synthetically useful isocyanide-based multicomponent reactions. Herein, we demonstrate that chiral isocyanoacetates can be used with minimal to negligible epimerization in a variety of canonical Ugi four-component condensations as well as Joullié-Ugi three-component condensations, reactions that are particularly useful for constructing complex peptide structures in a single synthetic operation.
authors: Department of Chemistry, Brown University, Providence, Rhode Island 02912, USA.
authors: Daniel W
authors: DW
authors: Carney
authors: Jonathan V
authors: JV
authors: Truong
authors: Jason K
authors: JK
authors: Sello