title: [Glutamate receptors and gamma-aminobutyric acid receptors in pancreatic cells].
abstract: Glutamate and gamma-aminobutyric acid (GABA) receptors are mainly expressed in central nervous system and play critical roles in neural signal transduction. It has been demonstrated that glutamate and GABA receptors are also found in pancreatic islets. Interestingly, almost all of glutamate and GABA receptor subunits are present in islets. Here, we summarize current progresses of these receptors in islets, focusing on there expressions, physiological implications, interactions, as well as a novel approach to investigate roles of the receptors in islets slice. All these investigations will potentially supply new understanding of working mechanism of these receptors in islet and also shed a new insight for neuroscientific research.
authors: Department of Neurobiology/Institute of Neuroscience, Key Laboratory of Zhejiang University School of Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.
authors: Zhen-yong
authors: ZY
authors: Wu
authors: Na
authors: N
authors: Zou
authors: Ying
authors: Y
authors: Shen
mesh_terms: D000818:Animals; D006801:Humans; D007515:Islets of Langerhans / Q000378:metabolism*; D018079:Receptors, GABA / Q000145:classification / Q000378:metabolism / Q000502:physiology*; D017470:Receptors, Glutamate / Q000145:classification / Q000378:metabolism / Q000502:physiology*
chemical_list: D018079:Receptors, GABA; D017470:Receptors, Glutamate