title: Direct condensation of sulfonamide and formamide: NaI-catalyzed synthesis of N-sulfonyl formamidine using TBHP as oxidant.
abstract: A new N-sulfonyl formamidine synthesis was developed via NaI-catalyzed direct condensation of sulfonamide and formamide. The green methodology is featured by high atom economy, easily available starting materials, the lack of need for a transition-metal catalyst, no requirement of hazardous reagent, operational simplicity, and good tolerance with diverse functional groups. Mechanistic studies suggest that the protocol proceeds based upon in situ generated TsN·NaI.
authors: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China.
authors: Shulin
authors: S
authors: Chen
authors: Yuan
authors: Y
authors: Xu
authors: Xiaobing
authors: X
authors: Wan
mesh_terms: D000578:Amidines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D005559:Formamides / Q000737:chemistry*; D015394:Molecular Structure; D016877:Oxidants / Q000737:chemistry*; D013449:Sulfonamides / Q000737:chemistry*
chemical_list: D000578:Amidines; D005559:Formamides; D016877:Oxidants; D013449:Sulfonamides; C077922:formamidine; C031066:formamide