title: Biological profile of erucin: a new promising anticancer agent from cruciferous vegetables.
abstract: Consumption of cruciferous vegetables has been associated with a reduced risk in the development of various types of cancer. This has been attributed to the bioactive hydrolysis products that are derived from these vegetables, namely isothiocyanates. Erucin is one such product derived from rocket salads, which is structurally related to sulforaphane, a well-studied broccoli-derived isothiocyanate. In this review, we present current knowledge on mechanisms of action of erucin in chemoprevention obtained from cell and animal models and relate it to other isothiocyanates. These mechanisms include modulation of phase I, II and III detoxification, regulation of cell growth by induction of apoptosis and cell cycle arrest, induction of ROS-mechanisms and regulation androgen receptor pathways.
authors: Foundation "Prof. Antonio Imbesi", Pharmaco-Biological Department, School of Pharmacy, University of Messina/Villaggio Annunziata, 98168 Messina, Italy. amelchini@pharma.unime.it
authors: Antonietta
authors: A
authors: Melchini
authors: Maria H
authors: MH
authors: Traka
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D019607:Brassicaceae / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D015536:Down-Regulation; D006801:Humans; D017382:Reactive Oxygen Species / Q000378:metabolism; D011944:Receptors, Androgen / Q000187:drug effects / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects; D013440:Sulfides / Q000494:pharmacology*; D013861:Thiocyanates / Q000494:pharmacology*; D015262:Xenobiotics / Q000378:metabolism
chemical_list: D016588:Anticarcinogenic Agents; D000972:Antineoplastic Agents, Phytogenic; D017382:Reactive Oxygen Species; D011944:Receptors, Androgen; D013440:Sulfides; D013861:Thiocyanates; D015262:Xenobiotics; C073539:erucin