title: [Research progress in molecular mechanism of animal seasonal reproduction].
abstract: Animal seasonal reproduction involves complicated neuroendocrine processes of the hypothalamo-pituitary-gonadal axis. It is dominantly regulated by photoperiod, a crucial environmental cue. Melatonin, as internal photoperiod signal, regulates seasonal reproduction of animals. In recent years, it has been found that Kiss1/GPR54 system, which may influence GnRH secretion evidently, is regulated by both melatonin and feedback action of gonadal steroid hormones. Consequently, Kiss1/GPR54 system may play a key role in seasonal reproduction. Additionally, there exists another potential retrograde control pathway of seasonal breeding, which involves TSH-DIO2/DIO3 system. TSH-DIO2/ DIO3 system affects synthesis and secretion of GnRH and is regulated by melatonin, as well as Kiss1/GPR54 system. In this article, melatonin signal, especially the research advances of Kissl/GPR54 system and TSH-DIO2/DIO3 system were reviewed.
authors: Key Laboratory of Farm Animal Genetic Resources and Utilization of Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Bejing 100193, China. hdwwxf@163.com
authors: Dong-Wei
authors: DW
authors: Huang
authors: Ming-Xing
authors: MX
authors: Chu
mesh_terms: D000818:Animals; D006728:Hormones / Q000378:metabolism*; D009490:Neurosecretory Systems / Q000378:metabolism* / Q000528:radiation effects; D017440:Photoperiod; D012098:Reproduction / Q000528:radiation effects; D012621:Seasons; D015398:Signal Transduction / Q000528:radiation effects
chemical_list: D006728:Hormones