title: Novel cytotoxic chalcones from Litsea rubescens and Litsea pedunculata.
abstract: Two novel flavonoids with chalcone skeleton, together with seven known flavonoids, were isolated from the stem barks of Litsea rubescens and Litsea pedunculata. The structures of the new compounds were elucidated on the basis of spectral methods including IR, UV, 1D and 2D NMR. The new chalcones were found to contain the rare epoxy or ethylidenedioxy group. This is the first report on the presence of chalcone in the plant genus Litsea. The cytotoxic potential of two new chalcones was evaluated in vitro against three human tumor cell lines. Both new chalcones displayed potent cytotoxic activities against myeloid leukaemia (HL-60) and epidermoid carcinoma (A431) cell lines and more active than cisplatin (DDP). Interestingly, compound 1 exhibited cytotoxic activity against HL-60 with IC(50) value 2.1-fold more sensitive to DDP.
authors: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.
authors: Liang
authors: L
authors: Li
authors: Xing-Tang
authors: XT
authors: Zhao
authors: Yi-Ping
authors: YP
authors: Luo
authors: Jing-Feng
authors: JF
authors: Zhao
authors: Xiao-Dong
authors: XD
authors: Yang
authors: Hong-Bing
authors: HB
authors: Zhang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D052117:Benzodioxoles / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D047188:Chalcones / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D006801:Humans; D032862:Litsea / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D024301:Plant Bark / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D052117:Benzodioxoles; D047188:Chalcones