title: [Myostatin blockade therapy for muscular atrophy].
abstract: Myostatin, a member of the muscle-specific transforming growth factor (TGF)-β family, negatively regulates skeletal muscle growth. It inhibits muscle stem cell proliferation and differentiation and attenuates adult muscle fiber protein accretion, resulting in decreased skeletal muscle mass. As such, it has been considered a therapeutic target of muscular dystrophy. Notably, administration of a blocking antibody against myostatin ameliorated the pathophysiology of dystrophin-deficient mdx mice. Although a clinical trial of anti-myostatin antibody MYO-029 failed to achieve a significant outcome in patients with muscular dystrophies, various distinct approaches have been taken to establish anti-myostatin therapy, including myostatin decoy receptor ACE-031, small-molecule inhibitors against the myostatin receptor, and myostatin short intertering RNA with collagen-derived carrier particles. The clinical application of anti-myostatin therapeutics in treatment of patients with muscular dystrophy needs further evaluation for safety and specification of the target disease types among the various muscular dystrophies. In addition, myostatin inhibition could be effective for muscle-wasting conditions other than muscular dystrophy- for instance, steroid-induced myopathy, mitochondrial myopathy, or sarcopenia in elderly patients. Moreover, considerable evidence shows that myostatin regulates energy metabolism and that its inhibition can significantly attenuate the progression of obesity and diabetes. It may also be applicable for the prevention of metabolic syndrome. Thus, safe and potent anti-myostatin therapy will have a wide variety of applications in modern medicine.
authors: Department of Neurology, Kawasaki Medical School, Kurashiki-City, Okayama, Japan.
authors: Yoshihide
authors: Y
authors: Sunada
mesh_terms: D030301:Activin Receptors, Type II / Q000627:therapeutic use; D000818:Animals; D057134:Antibodies, Neutralizing / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D058990:Molecular Targeted Therapy; D009133:Muscular Atrophy / Q000188:drug therapy* / Q000235:genetics*; D009154:Mutation; D055435:Myostatin / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D017434:Protein Structure, Tertiary; D034741:RNA, Small Interfering / Q000627:therapeutic use; D015398:Signal Transduction
chemical_list: D057134:Antibodies, Neutralizing; D055435:Myostatin; D034741:RNA, Small Interfering; D030301:Activin Receptors, Type II; C425584:activin receptor type II-B