title: Different types of cell death induced by enterotoxins.
abstract: The infection of bacterial organisms generally causes cell death to facilitate microbial invasion and immune escape, both of which are involved in the pathogenesis of infectious diseases. In addition to the intercellular infectious processes, pathogen-produced/secreted enterotoxins (mostly exotoxins) are the major weapons that kill host cells and cause diseases by inducing different types of cell death, particularly apoptosis and necrosis. Blocking these enterotoxins with synthetic drugs and vaccines is important for treating patients with infectious diseases. Studies of enterotoxin-induced apoptotic and necrotic mechanisms have helped us to create efficient strategies to use against these well-characterized cytopathic toxins. In this article, we review the induction of the different types of cell death from various bacterial enterotoxins, such as staphylococcal enterotoxin B, staphylococcal alpha-toxin, Panton-Valentine leukocidin, alpha-hemolysin of Escherichia coli, Shiga toxins, cytotoxic necrotizing factor 1, heat-labile enterotoxins, and the cholera toxin, Vibrio cholerae. In addition, necrosis caused by pore-forming toxins, apoptotic signaling through cross-talk pathways involving mitochondrial damage, endoplasmic reticulum stress, and lysosomal injury is discussed.
authors: Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. cflin@mail.ncku.edu.tw
authors: Chiou-Feng
authors: CF
authors: Lin
authors: Chia-Ling
authors: CL
authors: Chen
authors: Wei-Ching
authors: WC
authors: Huang
authors: Yi-Lin
authors: YL
authors: Cheng
authors: Chia-Yuan
authors: CY
authors: Hsieh
authors: Chi-Yun
authors: CY
authors: Wang
authors: Ming-Yuan
authors: MY
authors: Hong
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D059865:Endoplasmic Reticulum Stress; D004768:Enterotoxins / Q000633:toxicity*; D004926:Escherichia coli / Q000472:pathogenicity; D006801:Humans; D013211:Staphylococcus aureus / Q000472:pathogenicity; D014734:Vibrio cholerae / Q000472:pathogenicity
chemical_list: D004768:Enterotoxins