title: MVP and vaults: a role in the radiation response.
abstract: Vaults are evolutionary highly conserved ribonucleoproteins particles with a hollow barrel-like structure. The main component of vaults represents the 110 kDa major vault protein (MVP), whereas two minor vaults proteins comprise the 193 kDa vault poly(ADP-ribose) polymerase (vPARP) and the 240 kDa telomerase-associated protein-1 (TEP-1). Additionally, at least one small and untranslated RNA is found as a constitutive component. MVP seems to play an important role in the development of multidrug resistance. This particle has also been implicated in the regulation of several cellular processes including transport mechanisms, signal transmission and immune responses. Vaults are considered a prognostic marker for different cancer types. The level of MVP expression predicts the clinical outcome after chemotherapy in different tumour types. Recently, new roles have been assigned to MVP and vaults including the association with the insulin-like growth factor-1, hypoxia-inducible factor-1alpha, and the two major DNA double-strand break repair machineries: non-homologous endjoining and homologous recombination. Furthermore, MVP has been proposed as a useful prognostic factor associated with radiotherapy resistance. Here, we review these novel actions of vaults and discuss a putative role of MVP and vaults in the response to radiotherapy.
authors: Radiation Oncology Department, Hospital Universitario de Gran Canaria Dr Negrín, C/Barranco de La Ballena s/n, 35010, Las Palmas de Gran Canaria, Spain.
authors: Pedro C
authors: PC
authors: Lara
authors: Martin
authors: M
authors: Pruschy
authors: Martina
authors: M
authors: Zimmermann
authors: Luis Alberto
authors: LA
authors: Henríquez-Hernández
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D004249:DNA Damage; D004260:DNA Repair; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D059765:Homologous Recombination; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000532:radiotherapy*; D011379:Prognosis; D012313:RNA / Q000378:metabolism; D011878:Radiotherapy / Q000379:methods*; D020394:Vault Ribonucleoprotein Particles / Q000378:metabolism*
chemical_list: D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D020394:Vault Ribonucleoprotein Particles; D012313:RNA; D007334:Insulin-Like Growth Factor I