title: Resolution of a proteinuric nephropathy associated with Babesia gibsoni infection in a dog.
abstract: A 4 yr old male castrated Labrador retriever was evaluated for a short history of inappetance, lethargy, small-bowel diarrhea, polyuria, and polydipsia. Clinicopathologic abnormalities were consistent with protein-losing nephropathy and renal azotemia. Expansive infectious disease testing implicated Babesia gibsoni via whole blood polymerase chain reaction. Renal histopathology results were consistent with membranoproliferative glomerulonephritis and immune complex deposition. The dog was treated with azithromycin, atovaquone, and one dose of corticosteroids/cyclophosphamide. Three months after therapy was completed, the dog was clinically healthy, and all clinicopathologic abnormalities (including Babesia species polymerase chain reaction) had resolved. Atypical presentations of Babesia gibsoni should be considered with proteinuric nephropathy.
authors: Department of Clinical Studies, Matthew J. Ryan Veterinary Hospital, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, USA. dennis.slade.dvm@gmail.com
authors: Dennis J
authors: DJ
authors: Slade
authors: George E
authors: GE
authors: Lees
authors: Brian R
authors: BR
authors: Berridge
authors: Fred J
authors: FJ
authors: Clubb
authors: Leslie A
authors: LA
authors: Kuczynski
authors: Meryl P
authors: MP
authors: Littman
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage; D053626:Atovaquone / Q000008:administration & dosage; D017963:Azithromycin / Q000008:administration & dosage; D001403:Babesia / Q000235:genetics / Q000302:isolation & purification; D001404:Babesiosis / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D003520:Cyclophosphamide / Q000008:administration & dosage; D004269:DNA, Bacterial / Q000032:analysis; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D007674:Kidney Diseases / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D016133:Polymerase Chain Reaction / Q000662:veterinary; D011507:Proteinuria / Q000662:veterinary
chemical_list: D000981:Antiprotozoal Agents; D004269:DNA, Bacterial; D017963:Azithromycin; D003520:Cyclophosphamide; D053626:Atovaquone