title: Exercise and physical therapy in early management of Parkinson disease.
abstract: Experimental research has produced evidence in recent years underlying the beneficial effects that exercise can have in preventing and deceleration of the development of Parkinson disease. These beneficial effects are exerted through various mechanisms such as neuroprotection, neurotransmission, plasticity, neurogenesis, homeostasis, and neurotrophic factors. Studies on clinical application at an early stage are still scarce, although some results are encouraging. There are still many questions to determine the most suitable type of exercise (forced/voluntary), the time of its implementation, the duration, and the combination of strategies. Nonconventional therapies can play an important role in addition to exercise, and are so numerous that they could be adapted to the circumstances of patients, although there is no evidence to date that they could have a neuroprotective effect.
authors: Sección de Neurología, Hospital Universitario de Fuenlabrada, Madrid, Spain. falonso.hflr@salud.madrid.org
authors: Fernando
authors: F
authors: Alonso-Frech
authors: Juan Juni
authors: JJ
authors: Sanahuja
authors: Amelia Mendoza
authors: AM
authors: Rodriguez
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D019468:Disease Management; D015444:Exercise; D006801:Humans; D010300:Parkinson Disease / Q000503:physiopathology / Q000628:therapy*; D026741:Physical Therapy Modalities; D016896:Treatment Outcome