title: ParaCEST MRI contrast agents capable of derivatization via"click" chemistry.
abstract: A comprehensive series of lanthanide chelates has been prepared with a tetrapropargyl DOTAM type ligand. The complexes have been characterized by a combination of (1)H NMR, single-crystal X-ray crystallography, CEST and relaxation studies and have also been evaluated for potential use as paramagnetic chemical exchange saturation transfer (ParaCEST) contrast agents in magnetic resonance imaging (MRI). We demonstrate the functionalization of several chelates by means of alkyne-azide "click" chemistry in which a glucosyl azide is used to produce a tetra-substituted carbohydrate-decorated lanthanide complex. The carbohydrate periphery of the chelates has a potent influence on the CEST properties as described herein.
authors: Department of Chemistry, The University of Western Ontario, London, Ontario, Canada N6A 5B7.
authors: Mark
authors: M
authors: Milne
authors: Kirby
authors: K
authors: Chicas
authors: Alex
authors: A
authors: Li
authors: Robert
authors: R
authors: Bartha
authors: Robert H E
authors: RH
authors: Hudson
mesh_terms: D002614:Chelating Agents / Q000138:chemical synthesis / Q000737:chemistry*; D057930:Click Chemistry; D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry*; D018360:Crystallography, X-Ray; D028581:Lanthanoid Series Elements / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D002614:Chelating Agents; D003287:Contrast Media; D028581:Lanthanoid Series Elements; D009942:Organometallic Compounds