title: Evaluation of glycemic and oxidative/antioxidative status in the estradiol valerate-induced PCOS model of rats.
abstract: OBJECTIVE
  The aim of this study was to show glycemic and oxidative/antioxidative status (GOAS) in rats with estradiol valerate (EV)-induced polycystic ovarian syndrome.
  
  
  METHODS
  Thirty mature female rats were randomly allocated to EV-induced PCOS, sham and control groups. Malondialdehyde, catalase and fasting blood glucose levels were determined in order to evaluate GOAS.
  
  
  RESULTS
  There was a statistically significant difference between PCOS and control groups (p<0.001) for hemolysate MDA while no difference was determined for either catalase or fasting blood glucose levels. On histopathological examination, the EV-induced PCOS group revealed disease-characteristic ovarian morphology.
  
  
  CONCLUSIONS
  There was an increased compensation for oxidative stress by antioxidative biologic mechanisms in EV-induced PCOS rats. Interestingly, the sole result derived from this limited study is that the sesame oil+EV combination is not appropriate for the evaluation of oxidant-antioxidant status and also glycemic condition in PCOS. This study demonstrates the need for better designed experimental studies to elucidate the aetiopathogenesis of PCOS via novel techniques.
authors: Ege University Faculty of Medicine, Department of Obstetrics and Gynecology, TR-35100 Izmir, Turkey.
authors: Aysegul
authors: A
authors: Dikmen
authors: Ahmet Mete
authors: AM
authors: Ergenoglu
authors: Ahmet Ozgur
authors: AO
authors: Yeniel
authors: Ozlem Yilmaz
authors: OY
authors: Dilsiz
authors: Gulinnaz
authors: G
authors: Ercan
authors: Huseyin
authors: H
authors: Yilmaz
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D002374:Catalase / Q000378:metabolism; D004195:Disease Models, Animal; D004958:Estradiol / Q000031:analogs & derivatives* / Q000633:toxicity; D005260:Female; D015227:Lipid Peroxidation; D018384:Oxidative Stress; D011085:Polycystic Ovary Syndrome / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D004958:Estradiol; D002374:Catalase