title: [Oral paroxetine for premature ejaculation: a randomized controlled study].
abstract: OBJECTIVE
  To validate the therapeutic efficacy of paroxetine in the treatment of premature ejaculation (PE).
  
  
  METHODS
  Eighty PE patients up to the inclusion criteria were equally randomized to an experimental and a control group. We observed all the patients for 4 weeks and recorded the baseline data on intravaginal ejaculatory latency time (IELT) and sexual satisfaction scores, followed by oral medication of paroxetine at 20 mg/d for the patients in the experimental group and placebo for the controls. Thirty days after the treatment, we again recorded IELT and sexual satisfaction scores of the patients.
  
  
  RESULTS
  After the treatment, the experimental group showed significantly prolonged IELT ([5.75 +/- 1.24] min) and increased sexual satisfaction score (6.4 +/- 1.2) as compared with the baseline data ([0.89 +/- 0.21] min and [2.7 +/- 0.9]) (P < 0.01). The control group exhibited no significant differences before and after the medication either in the mean IELT or in sexual satisfaction scores ([1.06 +/- 0.28] min vs [0.97 +/- 0.18] min and 3.6 +/- 1.3 vs 3.1 +/- 1.1, P > 0.05).
  
  
  CONCLUSIONS
  Oral medication of paroxetine at 20 mg/d for 30 days could improve IELT and sexual satisfaction in PE patients.
authors: Department of Urology, The Affiliated Hospital of Chuanbei Medical University, Nanchong, Sichuan 637000, China. gzy009@yahoo.com.cn
authors: Zhi-yong
authors: ZY
authors: Gong
authors: Tie-long
authors: TL
authors: Tang
authors: Shu
authors: S
authors: Cui
authors: Ji-zhong
authors: JZ
authors: Wang
authors: Xian-zhong
authors: XZ
authors: Deng
mesh_terms: D000328:Adult; D004542:Ejaculation; D006801:Humans; D008297:Male; D017374:Paroxetine / Q000627:therapeutic use*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D012735:Sexual Dysfunction, Physiological / Q000188:drug therapy*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors