title: [The relationship between urinary albumin excretion and serum uric acid in general population].
abstract: OBJECTIVE
  To investigate the relationship between the urinary albumin excretion (UAE) and serum uric acid in general population.
  
  
  METHODS
  The study participants were derived from the epidemiological study on the association of metabolic syndrome and chronic kidney disease (CKD) in Pinggu district, Beijing. A total of 992 participants (463 men and 529 women) aged from 30 to 75 years were enrolled in this study. For each participant, UAE, serum uric acid, serum creatinine, and serum lipids were detected and other potential risk factors for CKD were surveyed.
  
  
  RESULTS
  (1) The frequencies of microalbuminuria, macroalbuminuria and hyperuricemia were 12.9%, 1.8% and 4.3% respectively. The persons with hyperuricemia had significantly higher frequency of albuminuria than those without hyperuricemia (37.2% vs 13.7%, P < 0.01). (2) The participants were divided according to the quartiles (25%, 50%, 75%) of serum uric acid level, and the frequencies of albuminuria in males were 13.2%, 13.9%, 17.2% and 25.4%, while those in females were 8.4%, 6.2%, 9.6% and 24.8%. (3) Multivariate logistic regression analysis showed, hyperuricemia was significantly associated with albuminuria in females (OR = 2.31, 95%CI 1.15-4.68; P = 0.02), but not in males. If the persons with reduced renal function were excluded, similar result still could be gained.
  
  
  CONCLUSIONS
  The prevalence of albuminuria increases gradually with uric acid elevation. Serum uric acid is an independent risk factor of elevated UAE, especially in females.
authors: Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
authors: Xiao-hong
authors: XH
authors: Fan
authors: Jian-fang
authors: JF
authors: Cai
authors: Bi-xia
authors: BX
authors: Gao
authors: Li-jun
authors: LJ
authors: Mou
authors: Jin-hong
authors: JH
authors: Li
authors: Xue-jiao
authors: XJ
authors: Liu
authors: Jun-xue
authors: JX
authors: Wu
authors: Qing-yan
authors: QY
authors: Meng
authors: Hai-yun
authors: HY
authors: Wang
authors: Li-li
authors: LL
authors: Liu
authors: Hang
authors: H
authors: Li
authors: Xue-mei
authors: XM
authors: Li
authors: Xue-wang
authors: XW
authors: Li
mesh_terms: D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000175:diagnosis / Q000453:epidemiology*; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000453:epidemiology / Q000378:metabolism; D008055:Lipids / Q000097:blood; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000378:metabolism; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*; D016482:Urinalysis
chemical_list: D008055:Lipids; D014527:Uric Acid; D003404:Creatinine