title: Pharmacokinetic modeling of glimepiride plasma concentration in healthy subjects.
abstract: OBJECTIVE
  To determine the pharmacokinetics of glimepiride, a sulfonylurea antidiabetic agent, after single dose administration in healthy subjects.
  
  
  METHODS
  Pharmacokinetic data for modeling were extracted from a single-center, randomized, single-dose, fasting state, two-way crossover bioequivalence study on 4 mg glimepiride in 24 healthy subjects.
  
  
  RESULTS
  Plasma concentrations of glimepiride were measured using a validated LC/MS/MS method. The pharmacokinetic parameters were calculated using non-compartmental analysis. Different pharmacokinetic models were tested to evaluate pharmacokinetics of glimepiride. The optimal model was chosen based on Akaike's Information Criteria.
  
  
  CONCLUSIONS
  Compartmental analysis demonstrated that oral glimepiride tablets obey one compartment open model with rapid absorption following a first order kinetics and a short half-life.
authors: "Gr. T. Popa" University of Medicine and Pharmacy, Iasi, Antibiotice SA, Iasi, Romania.
authors: Ioana Maria
authors: IM
authors: Antonesi
authors: Roxana
authors: R
authors: Potur
authors: D M
authors: DM
authors: Potur
authors: Cristina Mihaela
authors: CM
authors: Ghiciuc
authors: Cătălina Elena
authors: CE
authors: Lupuşoru
mesh_terms: D000284:Administration, Oral; D000328:Adult; D019540:Area Under Curve; D001786:Blood Glucose / Q000187:drug effects*; D018592:Cross-Over Studies; D005215:Fasting; D005260:Female; D006207:Half-Life; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D008297:Male; D008432:Mathematical Computing; D012016:Reference Values; D013453:Sulfonylurea Compounds / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D013607:Tablets
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D013453:Sulfonylurea Compounds; D013607:Tablets; C057619:glimepiride