title: Effect of omega-3 fatty acids on the modification of erythrocyte membrane fatty acid content including oleic acid in peritoneal dialysis patients.
abstract: Erythrocyte membrane fatty acids (FA), such as oleic acid, are related to acute coronary syndrome. There is no report about the effect of omega-3 FA on oleic acid in peritoneal dialysis (PD) patients. We hypothesized that omega-3 FA can modify erythrocyte membrane FA, including oleic acid, in PD patients. In a double-blind, randomized, placebo-controlled study, 18 patients who were treated with PD for at least 6 months were randomized to treatment for 12 weeks with omega-3 FA or placebo. Erythrocyte membrane FA content was measured by gas chromatography at baseline and after 12 weeks. The erythrocyte membrane content of eicosapentaenoic acid and docosahexaenoic acid was significantly increased and saturated FA and oleic acid were significantly decreased in the omega-3 FA supplementation group after 12 weeks compared to baseline. In conclusion, erythrocyte membrane FA content, including oleic acid, was significantly modified by omega-3 FA supplementation for 12 weeks in PD patients.
authors: Department of Internal Medicine, Dong-A University College of Medicine, Busan, Republic of Korea. anws@dau.ac.kr
authors: W S
authors: WS
authors: An
authors: S M
authors: SM
authors: Lee
authors: Y K
authors: YK
authors: Son
authors: S E
authors: SE
authors: Kim
authors: K H
authors: KH
authors: Kim
authors: J Y
authors: JY
authors: Han
authors: H R
authors: HR
authors: Bae
authors: Y
authors: Y
authors: Park
mesh_terms: D000328:Adult; D019587:Dietary Supplements; D004281:Docosahexaenoic Acids / Q000378:metabolism; D004311:Double-Blind Method; D015118:Eicosapentaenoic Acid / Q000378:metabolism; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019301:Oleic Acid / Q000378:metabolism*; D010352:Patient Dropouts; D010530:Peritoneal Dialysis; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D004281:Docosahexaenoic Acids; D019301:Oleic Acid; D015118:Eicosapentaenoic Acid