title: [Influence of HLA-G on immunoregulatory function of human amniotic mesenchymal cells].
abstract: Human leukocyte antigen G (HLA-G), a kind of non-classical major histocompatibility complex class I antigens, can inhibit inflammatory reaction, assist tumor cells to escape from immune surveillance and promote the immunologic tolerance of the graft. HLA-G, expressed and secreted by human amniotic mesenchymal cells (HAMC), suppresses the functions of NK cells, T cells and B cells and modulates the activity of dendritic cells (DC). These findings provide a theoretical basis for illustrating the mechanism of immunosuppression on HAMC. In this article, the recent advances on not only the gene and the molecular structure of HLA-G, but also the possible mechanisms of HLA-G in immunoregulatory function of HAMC, as well as the relation of HLA-G with HAMC, NK, DC, T and B cells are reviewed.
authors: Department of Hematology, Medical College of Ningbo University, Ningbo, Zhejiang Province, China.
authors: Jia-Ping
authors: JP
authors: Wang
authors: Gui-Fang
authors: GF
authors: Ouyang
mesh_terms: D000650:Amnion / Q000166:cytology*; D059951:HLA-G Antigens / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000276:immunology*
chemical_list: D059951:HLA-G Antigens