title: Erythema dyschromicum perstans in a Japanese child.
abstract: Erythema dyschromicum perstans (EDP) is asymptomatic slate-gray to blue-brown macules. Idiopathic eruptive macular pigmentation is asymptomatic brown nonconfluent macules. We describe electron microscopic studies of a 9-year-old Japanese girl with EDP. The ultrastructural figures indicated that the production of immature, small, irregular-shaped melanosomes in melanocytes and peripheral localization of melanosomes in keratinocytes caused the clinical appearance of EDP. The ultrastructural evidence distinguishes EDP from idiopathic eruptive macular pigmentation and suggests a distinct pathogenesis of the disease.
authors: Department of Dermatology, Faculty of Medicine Kinki University, Osaka-Sayama, Japan. naoiso@med.kindai.ac.jp
authors: Naoki
authors: N
authors: Oiso
authors: Daisuke
authors: D
authors: Tsuruta
authors: Hisayoshi
authors: H
authors: Imanishi
authors: Hiromi
authors: H
authors: Kobayashi
authors: Akira
authors: A
authors: Kawada
mesh_terms: D044466:Asian People; D002648:Child; D004890:Erythema / Q000473:pathology*; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000473:pathology*; D015603:Keratinocytes / Q000473:pathology / Q000648:ultrastructure; D008544:Melanocytes / Q000473:pathology / Q000648:ultrastructure; D020460:Melanosomes / Q000473:pathology / Q000648:ultrastructure