title: Effective inhibition of the early copper ion burst release with ultra-fine grained copper and single crystal copper for intrauterine device application.
abstract: To solve the main problems of existing coarse grained copper (CG Cu) intrauterine devices (IUD)-namely burst release and a low transfer efficiency of the cupric ions during usage-ultra-fine grained copper (UFG Cu) and single crystal copper (SC Cu) have been investigated as potential substitutes. Their corrosion properties with CG Cu as a control have been studied in simulated uterine fluid (SUF) under different conditions using electrochemical measurement methods. Long-term immersion of UFG Cu, SC Cu and CG Cu samples in SUF at 37 °C have been studied for 300 days. A lower copper ion burst release and a higher efficiency release of cupric ions were observed for UFG Cu and SC Cu compared with CG Cu in the first month of immersion and 2 months later. The respective corrosion mechanisms for UFG Cu, SC Cu and CG Cu in SUF are proposed. In vitro biocompatibility tests show a better cellular response to UFG Cu and SC Cu than CG Cu. In terms of instantaneous corrosion behavior, long-term corrosion performance and in vitro biocompatibility, the three pure copper materials follow the order: UFG Cu>SC Cu>CG Cu, which indicates that UFG Cu could be the most suitable candidate material for intrauterine devices.
authors: Center for Biomedical Materials and Engineering, Harbin Engineering University, Harbin 150001, People's Republic of China.
authors: X X
authors: XX
authors: Xu
authors: F L
authors: FL
authors: Nie
authors: Y B
authors: YB
authors: Wang
authors: J X
authors: JX
authors: Zhang
authors: W
authors: W
authors: Zheng
authors: L
authors: L
authors: Li
authors: Y F
authors: YF
authors: Zheng
mesh_terms: D000327:Adsorption / Q000187:drug effects; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000648:ultrastructure; D002417:Cattle; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003300:Copper / Q000737:chemistry* / Q000494:pharmacology; D003343:Corrosion; D003460:Crystallization; D004560:Electricity; D055664:Electrochemical Techniques; D006801:Humans; D007435:Intrauterine Devices, Copper; D007477:Ions; D008422:Materials Testing; D051379:Mice; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D010316:Particle Size; D056951:Photoelectron Spectroscopy; D010973:Platelet Adhesiveness / Q000187:drug effects; D012710:Serum Albumin, Bovine / Q000378:metabolism
chemical_list: D007477:Ions; D012710:Serum Albumin, Bovine; D003300:Copper