title: Primary adrenal angiosarcoma and functioning adrenocortical adenoma: an exceptional combined tumor.
abstract: BACKGROUND
  Primary adrenal angiosarcoma is an extremely rare neoplasm, as are combined tumors within a given adrenal lesion.
  
  
  METHODS
  A 35-year-old man presented with hypokalemic hypertension leading to the discovery of a 6 cm diameter malignant-appearing right adrenal tumor. The lesion displayed marked (18)F-fluorodeoxyglucose uptake on positron emission tomography scanning. Endocrine investigations revealed secretion of both cortisol and aldosterone by the neoplasm. The entire right adrenal gland along with the periadrenal fat tissue was removed during laparoscopic surgery.
  
  
  RESULTS
  Histological examination revealed two intermingled tumor cell proliferations, namely an angiosarcoma and an adrenocortical adenoma. An extensive post-operative search revealed no other primary tumor site, nor metastases. The lesion was then considered to be a primary adrenal angiosarcoma combined with a secreting adrenocortical adenoma. The patient received four cycles of chemotherapy (adriamycin/ifosfamide). At 2-year follow-up, he is alive and well, with no sign of relapse.
  
  
  CONCLUSIONS
  To the best of our knowledge, this is the first case of an adrenal neoplasm combining a primary angiosarcoma and a functioning adrenocortical adenoma.
authors: Unité d'Hypertension Artérielle, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, 20-40 rue Leblanc, F-75015 Paris, France. charlotte.lepoutre@egp.aphp.fr
authors: Charlotte
authors: C
authors: Lepoutre-Lussey
authors: Audrey
authors: A
authors: Rousseau
authors: Abir
authors: A
authors: Al Ghuzlan
authors: Laurence
authors: L
authors: Amar
authors: Chantal
authors: C
authors: Hignette
authors: Angela
authors: A
authors: Cioffi
authors: Franck
authors: F
authors: Zinzindohoué
authors: Sophie
authors: S
authors: Leboulleux
authors: Pierre-François
authors: PF
authors: Plouin
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis* / Q000601:surgery; D018246:Adrenocortical Adenoma / Q000175:diagnosis* / Q000601:surgery; D000328:Adult; D006801:Humans; D008297:Male; D049268:Positron-Emission Tomography