title: [Increasing antibiotic resistance: the prognostic impact has yet to be determined].
abstract: The rising prevalence of multiresistant bacteria has become a major clinical concern. Yet, the prognostic impact is not well elucidated. A growing number of studies have found associations between acquired resistance, inappropriate therapy and mortality. The key underlying factors seem to be delay of appropriate antibiotic therapy and possibly use of more toxic therapy. However, methodological issues including control group selection and adjustment for potential confounders must be taken into consideration when assessing outcome studies for patients infected with resistant microorganisms.
authors: Klinisk Mikrobiologisk Afdeling, Aarhus Universitetshospital, Aalborg Sygehus, 9100 Aalborg, Denmark. mette.soegaard@rn.dk
authors: Mette
authors: M
authors: Søgaard
authors: Henrik C
authors: HC
authors: Schønheyder
authors: Svend Stenvang
authors: SS
authors: Pedersen
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D017063:Outcome Assessment, Health Care; D011379:Prognosis; D011785:Quality Assurance, Health Care
chemical_list: D000900:Anti-Bacterial Agents