title: Ganglioglioma of the thoracolumbar spinal cord in a patient with neurofibromatosis type 1: a case report and literature review.
abstract: Gangliogliomas of the spinal cord are rare, and the conus medullaris is an extremely rare site for their occurrence. The authors present a case in which a ganglioglioma was found in the thoracolumbar spinal cord, including the conus medullaris, of a 5-year-old female patient with neurofibromatosis type 1 (NF1) who presented with paraparesis and urinary disturbance. MRI revealed an intramedullary lesion within the thoracolumbar spinal cord, including the conus medullaris, which was surgically removed. Pathological investigation showed a ganglioglioma consisting of glioneuronal tumor cells. This is the first report to provide a pathological description of a spinal cord ganglioglioma in a patient with NF1. Because gangliogliomas usually have a good prognosis following resection, it is important to clearly distinguish them from other NF1-associated lesions, even though ganglioglioma of the thoracolumbar spinal cord, including the conus medullaris, is an extremely rare condition.
authors: Department of Neurosurgery, Kanazawa University Hospital, Kanazawa, Japan. yuh@ns.m.kanazawa-u.ac.jp
authors: Yutaka
authors: Y
authors: Hayashi
authors: Mitsutoshi
authors: M
authors: Nakada
authors: Masanao
authors: M
authors: Mohri
authors: Hideki
authors: H
authors: Murakami
authors: Norio
authors: N
authors: Kawahara
authors: Jun-Ichiro
authors: J
authors: Hamada
mesh_terms: D002675:Child, Preschool; D005260:Female; D018303:Ganglioglioma / Q000150:complications* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008159:Lumbar Vertebrae; D009456:Neurofibromatosis 1 / Q000150:complications*; D013117:Spinal Cord Compression / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D013120:Spinal Cord Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D013904:Thoracic Vertebrae