title: Donor age-specific injury and immune responses.
abstract: Utilization rates of organs from elderly donors have shown the highest proportional increase during the last decade. Clinical reports support the concept of transplanting older organs. However, the engraftment of such organs has been linked to accelerated immune responses based on ageing changes per se and a proinflammatory environment subsequent to compromised injury and repair mechanism. We analyzed the clinical consequences of transplanting older donor organs and present mechanistic aspects correlating age, injury repair and effects on host immunoresponsiveness.
authors: Division of Transplant Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors: R
authors: R
authors: Oberhuber
authors: X
authors: X
authors: Ge
authors: S G
authors: SG
authors: Tullius
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008875:Middle Aged; D014019:Tissue Donors; D014947:Wounds and Injuries / Q000276:immunology*