title: Synthesis and growth regulatory activity of a prototype member of a new family of aminothiol radioprotectors.
abstract: The synthesis, growth inhibition and radioprotective activity of the PrC-210 aminothiol, 3-(methylamino)-2-((methylamino)methyl)propane-1-thiol, and its polyamine and thiolated polyamine progenitors are reported. All of the molecules significantly inhibited growth of cultured normal human fibroblasts. The combination of an ROS-scavenging thiol group and a positively charged alkyl-amine backbone provided the most radioprotective aminothiol molecule.
authors: ProCertus BioPharm, Inc., Madison, WI, USA.
authors: Richard R
authors: RR
authors: Copp
authors: Daniel D
authors: DD
authors: Peebles
authors: William E
authors: WE
authors: Fahl
mesh_terms: D000588:Amines / Q000737:chemistry; D000818:Animals; D002460:Cell Line; D003872:Dermatitis / Q000517:prevention & control; D003959:Diamines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004195:Disease Models, Animal; D006801:Humans; D011073:Polyamines / Q000737:chemistry; D011837:Radiation-Protective Agents / Q000138:chemical synthesis* / Q000737:chemistry; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: C570582:3-(methylamino)-2-((methylamino)methyl)propane-1-thiol; D000588:Amines; D003959:Diamines; D011073:Polyamines; D011837:Radiation-Protective Agents; D017382:Reactive Oxygen Species; D013438:Sulfhydryl Compounds