title: Pre-procedural Elevated White Blood Cell Count and Neutrophil-Lymphocyte (N/L) Ratio are Predictors of Ventricular Arrhythmias During Percutaneous Coronary Intervention.
abstract: OBJECTIVE
  The absolute white blood cell (WBC) count and neutrophil to lymphocyte (N/L) ratio are predictors of death/myocardial infarction in patients who have undergone coronary angiography. We hypothesized that a pre-procedural elevated WBC count and an elevated N/L ratio would be a predictor of development of significant ventricular arrhythmias in subjects undergoing percutaneous coronary intervention (PCI).
  
  
  RESULTS
  We retrieved the data for all patients developing ventricular arrhythmia during PCI between 1999 to 2009 from our cath lab database (from 30,798 records), a total of 70 patients (Group I), and tabulated their WBC counts and absolute neutrophil and lymphocyte counts as well as N/L ratios. We compared the data with a random group of age, gender, medications and pre-existing condition matched controls (n=70) (Group II). We also adjusted for amount of myocardium under jeopardy. Group I had a significantly higher total WBC count (means 14,344 Vs 6852; 95% CI; p=0.0004); neutrophil count (means 75.79% Vs 58.06%; 95% CI; p < 0.0001) and N/L ratio (means 3.79 Vs 1.56; 95% CI; p < 0.0001) [means compared with t test].
  
  
  CONCLUSIONS
  Our data suggests a pre-procedural elevated WBC count, neutrophils and elevated N/L ratio are predictors of significant ventricular arrhythmias in patients undergoing percutaneous coronary intervention (PCI).
authors: Maimonides Medical Center, Brooklyn, NY, Postal address: 864 49th Street Apt C11, Brooklyn, NY 11220. sauravchatterjeemd@gmail.com.
authors: Saurav
authors: S
authors: Chatterjee
authors: Preeti
authors: P
authors: Chandra
authors: Gunjan
authors: G
authors: Guha
authors: Vikas
authors: V
authors: Kalra
authors: Anasua
authors: A
authors: Chakraborty
authors: Robert
authors: R
authors: Frankel
authors: Jacob
authors: J
authors: Shani
mesh_terms: D000368:Aged; D001145:Arrhythmias, Cardiac / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D007958:Leukocyte Count / Q000379:methods*; D018655:Lymphocyte Count / Q000379:methods*; D008297:Male; D009504:Neutrophils / Q000378:metabolism*; D062645:Percutaneous Coronary Intervention / Q000379:methods*; D011379:Prognosis; D017180:Tachycardia, Ventricular / Q000097:blood* / Q000175:diagnosis