title: Metastasis of occult prostatic carcinoma to the sphenoid sinus: report of a rare case and a review of the literature.
abstract: We present a case (55-year-old) with a metastasis to the sphenoid sinus from an occult prostatic adenocarcinoma as the first evidence of disease. The patient's symptoms were progressive left-sided headache of a few months duration and a 2-week history of blurred vision with diplopia. Clinical examination revealed a left cranial nerve III palsy and ptosis. A computed tomography scan showed a 2 cm large, well delineated soft tissue lesion involving the left sphenoid sinus and extending to the left cavernous sinus with sclerosis of the adjacent sphenoid bone. Histological and immunohistochemical examinations revealed a poorly differentiated adenocarcinoma that was positive for prostate specific antigen (PSA) and broad-spectrum cytokeratins (Cam 5.2). Subsequent urological examination confirmed a locally advanced prostatic carcinoma with significantly increased serum-PSA (4,561 μg/l) and bone scintigraphy showed widespread metastasis.
authors: Department of Pathology, National University Health System, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore. fredrikpetersson@live.se
authors: Fredrik
authors: F
authors: Petersson
authors: Tan Sien
authors: TS
authors: Hui
authors: David
authors: D
authors: Loke
authors: Thomas Choudary
authors: TC
authors: Putti
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010255:Paranasal Sinus Neoplasms / Q000556:secondary*; D011471:Prostatic Neoplasms / Q000473:pathology*; D013101:Sphenoid Sinus / Q000473:pathology*