title: Significance of lutein in red blood cells of Alzheimer's disease patients.
abstract: Red blood cells (RBC) of Alzheimer's disease (AD) patients are known to be in an excessively oxidized state (i.e., with a high accumulation of peroxidized phospholipids (PLOOH)). Previously we confirmed in vitro, in vivo murine, and in human studies that carotenoids can effectively inhibit accumulation of RBC PLOOH. Thus, the relationship between RBC carotenoids and PLOOH concentrations in AD patients is of interest. In this study, RBC carotenoids and PLOOH were evaluated in 28 normal control subjects (age: 74.1 ± 1.3 years) and 28 patients with AD (age: 72.5 ± 1.4 years). The concentrations of RBC carotenoids, especially lutein, in AD patients were significantly lower than in control subjects. An inverse relationship was seen between RBC carotenoids, especially lutein, and PLOOH concentrations in AD patients. These results suggest that RBC lutein, in particular, may contribute to suppression of PLOOH accumulation in RBC of AD patients.
authors: Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
authors: Takehiro
authors: T
authors: Kiko
authors: Kiyotaka
authors: K
authors: Nakagawa
authors: Tsuyoshi
authors: T
authors: Tsuduki
authors: Toshihide
authors: T
authors: Suzuki
authors: Hiroyuki
authors: H
authors: Arai
authors: Teruo
authors: T
authors: Miyazawa
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000097:blood* / Q000473:pathology; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid; D004563:Electrochemistry / Q000379:methods; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D014975:Lutein / Q000097:blood*; D008297:Male; D018709:Statistics, Nonparametric
chemical_list: D008054:Lipid Peroxides; D014975:Lutein