title: Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to treatment in patients with major depressive disorder.
abstract: The present study is aimed to exploring whether some single nucleotide polymorphisms (SNPs) within GRIA1, GRIA2 and GRIA4 could be associated with major depressive disorder (MDD) and whether they could predict clinical outcomes in Korean in-patients, respectively, treated with antidepressants. One hundred forty-five (145) patients with MDD and 170 healthy controls were genotyped for 17 SNPs within GRIA1, GRIA2 and GRIA4. Baseline and final clinical measures, including the Montgomery-Asberg Depression Rating Scale (MADRS) for patients with MDD, were recorded. No association was observed between alleles, genotypes and haplotypes under investigation and clinical and demographical variables. As a secondary finding, a marginal association was observed between rs4302506 and rs4403097 alleles within GRIA2 and age of onset in patients with MDD. Our findings provide evidence for a possible association between rs4302506 and rs4403097 SNPs and age of onset in patients with MDD. However, taking into account that the several limitations of our study including the moderately small sample size of our study, our findings should be considered with caution and further research is needed to draw more definitive conclusions.
authors: Institute of Psychiatry, University of Bologna, Bologna, Italy.
authors: Alberto
authors: A
authors: Chiesa
authors: Concetta
authors: C
authors: Crisafulli
authors: Stefano
authors: S
authors: Porcelli
authors: Changsu
authors: C
authors: Han
authors: Ashwin A
authors: AA
authors: Patkar
authors: Soo-Jung
authors: SJ
authors: Lee
authors: Moon Ho
authors: MH
authors: Park
authors: Tae-Youn
authors: TY
authors: Jun
authors: Alessandro
authors: A
authors: Serretti
authors: Chi-Un
authors: CU
authors: Pae
mesh_terms: D000328:Adult; D017668:Age of Onset; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000009:adverse effects; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D010597:Pharmacogenetics / Q000379:methods; D020641:Polymorphism, Single Nucleotide; D011569:Psychiatric Status Rating Scales; D018091:Receptors, AMPA / Q000235:genetics*; D056910:Republic of Korea / Q000453:epidemiology; D009435:Synaptic Transmission / Q000235:genetics; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D018091:Receptors, AMPA; C104724:glutamate receptor ionotropic, AMPA 4; C104722:glutamate receptor ionotropic, AMPA 2