title: Statin dose in Asians: is pharmacogenetics relevant?
abstract: Historically the efficacy and safety of statins has mostly been studied in western populations. Few such studies have been carried out in Asians until recent years. These studies revealed interesting similarities and differences for statin use between Asians and Caucasians. One clinically important question subsequently raised is whether Asians need lower statin doses compared with Caucasians. Many practicing physicians believe that statin doses are lower in Asians because of the generally lower bodyweight and BMI. Whether this belief is based on sound scientific evidence needs to be reviewed. Furthermore, since the decision of optimal dose is based on both efficacy and safety, both of which may be impacted by genetic factors, one may ask whether pharmacogenetics plays a role in the dose difference, if such a difference exists. There is a clinical need to critically and comprehensively article the literature to answer these questions, and summarize future directions of research in the field. This article serves the above purpose.
authors: Department of Pathology & Laboratory Medicine, The Methodist Hospital & The Methodist Hospital Research Institute, Houston, TX 77030, USA. pwang@tmhs.org
authors: Ping
authors: P
authors: Wang
mesh_terms: D044466:Asian People / Q000235:genetics*; D054316:Biomarkers, Pharmacological; D015992:Body Mass Index; D001835:Body Weight / Q000235:genetics; D051544:Cytochrome P-450 CYP3A / Q000235:genetics*; D056726:Genetic Association Studies; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage* / Q000493:pharmacokinetics; D027381:Liver-Specific Organic Anion Transporter 1; D027361:Organic Anion Transporters / Q000235:genetics*; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic; D044465:White People / Q000235:genetics*
chemical_list: D054316:Biomarkers, Pharmacological; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D027381:Liver-Specific Organic Anion Transporter 1; D027361:Organic Anion Transporters; C503999:SLCO1B1 protein, human; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human