title: Levosimendan in two neonates with ischemic heart failure and pulmonary hypertension.
abstract: We report the successful and safe use of levosimendan, a new calcium-sensitizing agent with positive inotropic and vasodilatory action, in 2 critically ill term newborns with acute heart failure and pulmonary hypertension in the absence of any underlying heart malformation and/or previous cardiosurgical procedures. During the neonatal period, levosimendan may represent an ideal drug for immature myocardium characterized by a higher calcium-dependent contractility than in adults.
authors: Neonatal ICU, Department of Pediatrics, Catholic University of the Sacred Heart, A. Gemelli Hospital, Rome, Italy. mpia.decarolis @ rm.unicatt.it
authors: Maria Pia
authors: MP
authors: De Carolis
authors: Marco
authors: M
authors: Piastra
authors: Iliana
authors: I
authors: Bersani
authors: Manuela
authors: M
authors: Pardeo
authors: Eleonora
authors: E
authors: Stival
authors: Alessia
authors: A
authors: Tempera
authors: Costantino
authors: C
authors: Romagnoli
authors: Giorgio
authors: G
authors: Conti
authors: Gabriella
authors: G
authors: De Rosa
mesh_terms: D002316:Cardiotonic Agents / Q000627:therapeutic use*; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D006835:Hydrazones / Q000627:therapeutic use*; D006976:Hypertension, Pulmonary / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D007231:Infant, Newborn; D008297:Male; D017202:Myocardial Ischemia / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D011724:Pyridazines / Q000627:therapeutic use*; D000077464:Simendan; D016896:Treatment Outcome
chemical_list: D002316:Cardiotonic Agents; D006835:Hydrazones; D011724:Pyridazines; D000077464:Simendan