title: Polyaspartic acid coated manganese oxide nanoparticles for efficient liver MRI.
abstract: We report in this communication a simple, facile surface modification strategy to transfer hydrophobic manganese oxide nanoparticles (MONPs) into water by using polyaspartic acid (PASP). We systematically investigated the effect of the size of PASP-MONPs on MRI of normal liver and found that the particles with a core size of 10 nm exhibited greater enhancement than those with larger core sizes.
authors: Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA.
authors: Ruijun
authors: R
authors: Xing
authors: Fan
authors: F
authors: Zhang
authors: Jin
authors: J
authors: Xie
authors: Maria
authors: M
authors: Aronova
authors: Guofeng
authors: G
authors: Zhang
authors: Ning
authors: N
authors: Guo
authors: Xinglu
authors: X
authors: Huang
authors: Xiaolian
authors: X
authors: Sun
authors: Gang
authors: G
authors: Liu
authors: L Henry
authors: LH
authors: Bryant
authors: Ashwinkumar
authors: A
authors: Bhirde
authors: Amy
authors: A
authors: Liang
authors: Yanglong
authors: Y
authors: Hou
authors: Richard D
authors: RD
authors: Leapman
authors: Shouheng
authors: S
authors: Sun
authors: Xiaoyuan
authors: X
authors: Chen
mesh_terms: D000818:Animals; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology; D003287:Contrast Media / Q000737:chemistry / Q000494:pharmacology; D008099:Liver / Q000000981:diagnostic imaging*; D008277:Magnesium Oxide / Q000737:chemistry / Q000494:pharmacology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology; D011859:Radiography
chemical_list: D020099:Coated Materials, Biocompatible; D003287:Contrast Media; D010455:Peptides; C017645:polyaspartate; D008277:Magnesium Oxide