title: Mean Platelet Volume and Platelet Distribution Width in non-diabetic subjects with obstructive sleep apnoea syndrome: new indices of severity?
abstract: To evaluate Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW) in non-diabetic subjects, according to obstructive sleep apnoea syndrome (OSAS) severity and the associations of these indices with anthropometric characteristics and parameters of breathing function during sleep.
  
  
  METHODS
  We included 610 non-diabetic subjects with suspected OSAS, evaluated by polysomnography. According to their apnoea-hypopnoea index (AHI), patients were divided into Group A (n=148) with AHI<5/h; Group B (n=121) with AHI: 5-14.9/h; Group C (n=85) with AHI: 15-29.9/h and Group D (n=256) with AHI ≥ 30/h. MPV and PDW were measured using an automated blood cell counter.
  
  
  RESULTS
  MPV was significantly higher in group D (mean value 12.1 ± 1.3 fl) than in groups A (9.8 ± 1.1 fl), B (9.8 ± 1.6 fl), and C (11.5 ± 1.3 fl) (p<0.001). The same pattern was observed in PDW values (15.9 ± 2.2 fl for group D and 13.2 ± 2.2 fl for group A, 14.1 ± 2.8 fl for group B, and 15 ± 2.2 fl for group C, p<0.001). Significant correlations were seen between MPV and AHI (p<0.001), average pulse oxygen saturation (SpO(2)) (p<0.001), minimum SpO(2) (p<0.001) and percent of the total sleep time with SpO(2) lower than 90% (t<90%) (p<0.001) during sleep, Arousal Index (p<0.001) and Epworth sleepiness scale (ESS) (p=0.028). Similarly, PDW was correlated with AHI (p<0.001), average SpO(2) (p=0.001), minimum SpO(2) (p<0.001), t<90% (p=0.002), and Arousal Index (p<0.001).
  
  
  CONCLUSIONS
  MPV and PDW are higher in non-diabetic patients with severe OSAS and are correlated with different parameters of breathing function during sleep.
authors: Sleep Laboratory, Department of Pneumonology, Second Department of Internal Medicine, Medical School, Democritus University of Thrace, Greece.
authors: E
authors: E
authors: Nena
authors: N
authors: N
authors: Papanas
authors: P
authors: P
authors: Steiropoulos
authors: P
authors: P
authors: Zikidou
authors: P
authors: P
authors: Zarogoulidis
authors: E
authors: E
authors: Pita
authors: T C
authors: TC
authors: Constantinidis
authors: E
authors: E
authors: Maltezos
authors: D P
authors: DP
authors: Mikhailidis
authors: D
authors: D
authors: Bouros
mesh_terms: D000368:Aged; D000886:Anthropometry; D001772:Blood Cell Count; D001792:Blood Platelets / Q000473:pathology*; D048429:Cell Size; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen; D017286:Polysomnography; D012119:Respiration; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis / Q000473:pathology*; D012894:Sleep Stages
chemical_list: D010100:Oxygen