title: Oral delivery of the appetite suppressing peptide hPYY(3-36) through the vitamin B12 uptake pathway.
abstract: hPYY(3-36) injections have shown positive effects on appetite regulations, sparking increased interest in hPYY(3-36) research. Of great interest is oral delivery of hPYY(3-36) that can achieve clinically relevant weight-loss outcomes in what would be a highly patient compliant route. Successful oral delivery of other peptides utilizing the vitamin B12 pathway has been shown but below clinically relevant levels. Herein, we present clinically relevant in vivo oral delivery of B12-hPYY(3-36) conjugates.
authors: Department of Chemistry, Center for Science and Technology, Syracuse University, 111 College Place, Syracuse, New York 13244, United States.
authors: Christopher H
authors: CH
authors: Fazen
authors: Debbie
authors: D
authors: Valentin
authors: Timothy J
authors: TJ
authors: Fairchild
authors: Robert P
authors: RP
authors: Doyle
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001067:Appetite Depressants / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D006801:Humans; D010446:Peptide Fragments; D019894:Peptide YY / Q000008:administration & dosage* / Q000097:blood / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction; D014805:Vitamin B 12 / Q000008:administration & dosage* / Q000097:blood / Q000737:chemistry
chemical_list: D001067:Appetite Depressants; D010446:Peptide Fragments; D019894:Peptide YY; C061785:peptide YY (3-36); D014805:Vitamin B 12