title: Influence of microstructure and chemical composition of sputter deposited TiO2 thin films on in vitro bioactivity.
abstract: Functionalisation of biomedical implants via surface modifications for tailored tissue response is a growing field of research. Crystalline TiO(2) has been proven to be a bone bioactive, non-resorbable material. In contact with body fluids a hydroxyapaptite (HA) layer forms on its surface facilitating the bone contact. Thus, the path of improving biomedical implants via deposition of crystalline TiO(2) on the surface is interesting to follow. In this study we have evaluated the influence of microstructure and chemical composition of sputter deposited titanium oxide thin films on the in vitro bioactivity. We find that both substrate bias, topography and the flow ratio of the gases used during sputtering affect the HA layer formed on the films after immersion in simulated body fluid at 37°C. A random distribution of anatase and rutile crystals, formed at negative substrate bias and low Ar to O(2) gas flow ratios, are shown to favor the growth of flat HA crystal structures whereas higher flow ratios and positive substrate bias induced growth of more spherical HA structures. These findings should provide valuable information when optimizing the bioactivity of titanium oxide coatings as well as for tailoring process parameters for sputtered-based production of bioactive titanium oxide implant surfaces.
authors: Division for Nanotechnology and Functional Materials, Department of Engineering Sciences, The Ångström Laboratory, Uppsala University, Uppsala, Sweden.
authors: Mirjam
authors: M
authors: Lilja
authors: Axel
authors: A
authors: Genvad
authors: Maria
authors: M
authors: Astrand
authors: Maria
authors: M
authors: Strømme
authors: Håkan
authors: H
authors: Enqvist
mesh_terms: D001128:Argon / Q000737:chemistry; D001826:Body Fluids; D001842:Bone and Bones / Q000378:metabolism; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D003460:Crystallization; D017886:Durapatite / Q000737:chemistry; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D010100:Oxygen / Q000737:chemistry; D019736:Prostheses and Implants; D011474:Prosthesis Design; D012825:Silicon / Q000737:chemistry; D013499:Surface Properties; D013696:Temperature; D014025:Titanium / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D020099:Coated Materials, Biocompatible; C009495:titanium dioxide; D001128:Argon; D017886:Durapatite; D014025:Titanium; D010100:Oxygen; D012825:Silicon