title: Synthesis and evaluation of oligonucleotide-conjugated pyrrole polyamide-2'-deoxyguanosine hybrids as novel gene expression control compounds.
abstract: DNA oligonucleotide-conjugated pyrrole polyamide-2'-deoxyguanosine hybrids were synthesized and examined as novel gene expression control compounds. The T(m) values and circular dichroism spectral analyses showed that the oligonucleotide-conjugated hybrids possess high DNA recognition and a very high binding affinity for DNA that includes the pyrrole polyamide binding sequence.
authors: School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan.
authors: Etsuko
authors: E
authors: Kawashima
authors: Yusuke
authors: Y
authors: Ohba
authors: Yusuke
authors: Y
authors: Terui
authors: Kazuo
authors: K
authors: Kamaike
mesh_terms: D004247:DNA / Q000378:metabolism*; D003849:Deoxyguanosine / Q000138:chemical synthesis / Q000737:chemistry*; D015870:Gene Expression / Q000187:drug effects*; D009757:Nylons / Q000138:chemical synthesis / Q000737:chemistry*; D016376:Oligonucleotides, Antisense / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D009757:Nylons; D016376:Oligonucleotides, Antisense; D011758:Pyrroles; D004247:DNA; D003849:Deoxyguanosine