title: [Drug resistance of Pseudomonas aeruginosa in four community hospitals: influence of antimicrobial use density].
abstract: We investigated the relation between hospital antimirobial use density (AUD) and minimum inhibitory concentrations (MIC) for Pseudomonas aeruginosa in four community hospitals. Subjects were a total of 476 strains isolated from urine, sputum, and pus during a total of seven years since 2002, for which 50- and 90-percentile MICs were analyzed. Hospitals A, B, and C moved in 2000, 2005, and 2009, respectively, but MIC50 and MIC90 were stable. MIC values showed significance in five drugs, in which Hospital B showed maximal values in five and Hospital D showed minimal values in four drugs. AUD values were different in nine drugs, Hospital B showing the highest data in meropenem, flomoxef, and sulbactam/cefoperazone while Hospital D having the lowest data in meropenem, ceftazidime, cefotaxime, and sulbactam/cefoperazone. Thus MIC for P aeruginosa may show resistance in the presence of high AUD with wide antimicrobial spectrum.
authors: Shimonoseki City Central Hospital.
authors: Junichi
authors: J
authors: Yoshida
authors: Kaori
authors: K
authors: Akagi
authors: Toshiyuki
authors: T
authors: Ishimaru
authors: Noboru
authors: N
authors: Oshita
authors: Hideto
authors: H
authors: Obata
authors: Tsutomu
authors: T
authors: Kikuchi
authors: Tetsuya
authors: T
authors: Kikuchi
authors: Yutaka
authors: Y
authors: Sato
authors: Ryohei
authors: R
authors: Nawata
authors: Hirohito
authors: H
authors: Hayashi
authors: Fukuoka
authors: F
authors: Yoshihisa
authors: Nobuo
authors: N
authors: Matsubara
authors: Yoshihide
authors: Y
authors: Minami
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents; D002442:Ceftazidime / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D004363:Drug Utilization / Q000706:statistics & numerical data*; D006764:Hospitals, Community / Q000706:statistics & numerical data*; D006801:Humans; D007564:Japan; D000077731:Meropenem; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification*; D013845:Thienamycins / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D013845:Thienamycins; D002939:Ciprofloxacin; D002442:Ceftazidime; D000077731:Meropenem