title: A genetic variant in the promoter region of Toll-like receptor 9 and cervical cancer susceptibility.
abstract: The Toll-like receptors (TLRs) are important for the innate immune system by recognizing pathogen-associated molecular patterns expressed in infectious agents. E6 and E7 protein from HPV16 suppress the host immune response by regulating the TLR9 transcript. Therefore, we hypothesized that a single nucleotide polymorphism in TLR9 may contribute to cervical cancer. We genotyped TLR9 -1486T/C (rs187084) in a case-control study of 712 cervical cancer cases and 717 cancer-free controls in Chinese women. Logistic regression analyses showed that the rs187084 heterozygote TC was associated with a significantly increased risk of cervical cancer (adjusted OR=1.28, 95% CI=1.01-1.62), compared with the TT genotype. Although the variant homozygote was associated with a nonsignificantly increased cervical cancer risk, the TC/CC genotypes contributed to the risk of cervical cancer in the dominant genetic model (adjusted OR=1.24, 95% CI=1.01-1.53). The findings indicate that TLR9 -1486T/C (rs187084) may contribute to cervical cancer carcinogenesis.
authors: Tumor Hospital of Nantong City, Nantong, China.
authors: Xiaojun
authors: X
authors: Chen
authors: Sumin
authors: S
authors: Wang
authors: Li
authors: L
authors: Liu
authors: Zengyan
authors: Z
authors: Chen
authors: Fulin
authors: F
authors: Qiang
authors: Yanjing
authors: Y
authors: Kan
authors: Yan
authors: Y
authors: Shen
authors: Jiangping
authors: J
authors: Wu
authors: Hongbing
authors: H
authors: Shen
authors: Zhibin
authors: Z
authors: Hu
mesh_terms: D018196:Carcinoma, Adenosquamous / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D016022:Case-Control Studies; D002584:Cervix Uteri / Q000378:metabolism / Q000473:pathology; D004247:DNA / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012307:Risk Factors; D051217:Toll-Like Receptor 9 / Q000235:genetics*; D002583:Uterine Cervical Neoplasms / Q000235:genetics*
chemical_list: C495371:TLR9 protein, human; D051217:Toll-Like Receptor 9; D004247:DNA