title: Salt effect of nisin Z isolated from a marine fish on the growth inhibition of Streptococcus iniae, a pathogen of streptococcosis.
abstract: A bacteriocin-producing Lactococcus lactis subsp. lactis was isolated from the intestine of olive flounder. The bacteriocin was identified as nisin Z. It was active against Gram-positive bacteria. Nisin Z at 3,200 arbitrary units (AU) was more effective in seawater than in PBS; growth of Streptococcus iniae was completely inhibited within 3 h. Nisin Z preparations with 3.5% (w/v) NaCl was the most effective against S. iniae being similar to nisin Z in seawater. Nisin Z is thus a good alternative to antibiotics to prevent streptococcosis caused by S. iniae aquaculture systems.
authors: Department of Biotechnology, Pukyong National University, Busan, 608-737, Korea. heowonsuk@nate.com
authors: Won-Seok
authors: WS
authors: Heo
authors: Eun-Young
authors: EY
authors: Kim
authors: Yu-Ri
authors: YR
authors: Kim
authors: Muhammad Tofazzal
authors: MT
authors: Hossain
authors: In-Soo
authors: IS
authors: Kong
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology; D015169:Colony Count, Microbial; D003470:Culture Media / Q000737:chemistry; D004357:Drug Synergism; D005399:Fishes / Q000382:microbiology; D041981:Gastrointestinal Tract / Q000382:microbiology; D013294:Lactococcus lactis / Q000302:isolation & purification / Q000378:metabolism*; D050296:Microbial Viability / Q000187:drug effects; D009561:Nisin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D012492:Salts / Q000494:pharmacology*; D012623:Seawater / Q000382:microbiology; D013291:Streptococcus / Q000187:drug effects* / Q000254:growth & development*
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media; D012492:Salts; D009561:Nisin; C071364:nisin Z