title: The potential role of preventing atherosclerosis by induction of neonatal tolerance to VLDL.
abstract: Induction of immune tolerance to ox-LDL could reduce atherosclerosis by modulation immune response. We suppose that very low density lipoprotein (VLDL) may have a similar role to ox-LDL in autoimmune response of atherosclerosis. In this study, neonatal rats were injected with ox-LDL, VLDL, or equal-volume saline, respectively. Vaccination with ox-LDL reduced the level of specific antibody, T cells proliferation response, and the level of endothelins. The method also had a tendency of reducing blood lipids. Vaccination with VLDL obviously reduced the level of specific antibody and T cells proliferation. Though there was also a tendency of reducing blood lipids and endothelins, the effect was less prominent than that with ox-LDL. We conclude that, although the effect was less obvious, vaccination with VLDL to induce neonatal tolerance had an effect on modulating immune response, protecting endothelial cells, and reducing blood lipids.
authors: Department of Epidemiology and Biostatistics, School of Public Health, Shandong University, Jinan, China.
authors: Kai
authors: K
authors: Cui
authors: Guihua
authors: G
authors: Hou
authors: Yueqiu
authors: Y
authors: Feng
authors: Ting
authors: T
authors: Liang
authors: Feng
authors: F
authors: Kong
authors: Lin
authors: L
authors: Sun
authors: Shumei
authors: S
authors: Wang
mesh_terms: D000818:Animals; D000906:Antibodies / Q000097:blood / Q000276:immunology; D050197:Atherosclerosis / Q000276:immunology* / Q000517:prevention & control*; D049109:Cell Proliferation; D042783:Endothelial Cells / Q000276:immunology; D016232:Endothelins / Q000097:blood; D007108:Immune Tolerance / Q000276:immunology*; D008055:Lipids / Q000097:blood; D008077:Lipoproteins, LDL / Q000008:administration & dosage / Q000276:immunology; D008079:Lipoproteins, VLDL / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013601:T-Lymphocytes / Q000276:immunology*; D014611:Vaccination / Q000379:methods
chemical_list: D000906:Antibodies; D016232:Endothelins; D008055:Lipids; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; C099252:oxidized low density lipoprotein