title: Successful treatment of immunoglobulin D myeloma by bortezomib and dexamethasone therapy.
abstract: Immunoglobulin D (IgD) myeloma is a rare subtype and it is widely accepted as an aggressive disease. Here, we report a 66-year-old woman with IgD myeloma who had anemia, lumbago, multiple osteolytic lesions and hypercalcemia. The patient refused a blood transfusion because of her beliefs, so we administered bortezomib and dexamethasone (BD) after high-dose dexamethasone therapy. Marked improvement of anemia and elevated serum alkaline phosphatase levels was recognized. After 5 cycles of BD therapy, the patient achieved a stringent complete response according to International Myeloma Working Group Response Criteria. BD therapy might be a feasible and useful treatment option for IgD myeloma.
authors: Hematology Division, National Hospital Organization Disaster Medical Center, Japan. nao26@aol.com
authors: Naohiro
authors: N
authors: Sekiguchi
authors: Naoki
authors: N
authors: Takezako
authors: Akihisa
authors: A
authors: Nagata
authors: Miyuki
authors: M
authors: Wagatsuma
authors: Satoshi
authors: S
authors: Noto
authors: Kazuaki
authors: K
authors: Yamada
authors: Akiyoshi
authors: A
authors: Miwa
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001897:Boronic Acids / Q000008:administration & dosage; D000069286:Bortezomib; D003907:Dexamethasone / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007072:Immunoglobulin D / Q000096:biosynthesis*; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000188:drug therapy* / Q000276:immunology; D011719:Pyrazines / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D001897:Boronic Acids; D007072:Immunoglobulin D; D011719:Pyrazines; D000069286:Bortezomib; D003907:Dexamethasone