title: The role of asymmetric dimethyl arginine and oxidant/antioxidant system in preeclampsia.
abstract: Preeclampsia is a syndrome characterized by hypertension and proteinuria. The aim of this study is to find the relationship between preeclampsia, asymmetric dimethyl arginine (ADMA), and the oxidant/antioxidant system. Twenty-one preeclamptic and 28 normal pregnant women were included in this study. In cord bloods, ADMA and oxidant/antioxidant parameters were measured. Asymmetric dimethyl arginine levels were significantly increased in preeclamptic pregnancies compared to the control group (p = 0.006). The activities of antioxidant enzymes and malondialdehyde levels were increased in the preeclamptic group compared to the control group (p < 0.001, p = 0.022, p < 0.001, p < 0.001, respectively). Development of endothelial dysfunction and oxidative stress may play a role in developing preeclampsia.
authors: Department of Medical Biochemistry, Hacettepe University School of Medicine,   Ankara,   Turkey.
authors: Hasan
authors: H
authors: Alacam
authors: Z Gunnur
authors: ZG
authors: Dikmen
authors: Halil
authors: H
authors: Yaman
authors: Erdinc
authors: E
authors: Cakir
authors: Ozgur
authors: O
authors: Deren
authors: E Ozgur
authors: EO
authors: Akgul
authors: Ibrahim
authors: I
authors: Aydin
authors: Yasemin Gulcan
authors: YG
authors: Kurt
authors: Ugur
authors: U
authors: Keskin
authors: Sukran
authors: S
authors: Akalin
authors: Belgin
authors: B
authors: Polat
authors: Nuri
authors: N
authors: Danisman
authors: Pakize
authors: P
authors: Dogan
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D016022:Case-Control Studies; D002956:Citrulline / Q000097:blood; D005260:Female; D005312:Fetal Blood; D006801:Humans; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000097:blood; D016877:Oxidants / Q000097:blood; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000097:blood* / Q000209:etiology*; D011247:Pregnancy; D055815:Young Adult
chemical_list: D000975:Antioxidants; D016877:Oxidants; D002956:Citrulline; D008315:Malondialdehyde; C018524:N,N-dimethylarginine; D001120:Arginine