title: Iron topochemistry and surface reactivity of amphibole asbestos: relations with in vitro toxicity.
abstract: Chemical reactivity of asbestos tremolite from Italy and USA localities and Union Internationale Contre le Cancer (UICC) crocidolite was studied in relation to Fe content, oxidation state, and structural coordination. Direct correlation between amount of Fe(2+) at the exposed M(1) and M(2) sites of the amphibole structure and fiber chemical reactivity was established. The in vitro toxicity of the same samples was investigated on human alveolar A549 cell line. Relationship between crystal-chemical features and cell toxicity is not straightforward. UICC crocidolite has Fe content and chemical reactivity largely higher than that of tremolite samples, but all show comparable in vitro toxic potential. Results obtained evidenced that Fe topochemistry is not a primary factor for induced cell toxicity, though it accounts for asbestos chemical reactivity (and possibly genotoxicity).
authors: Dipartimento di Scienze della Terra, Sapienza Università di Roma, Rome, Italy. alessandro.pacella@uniroma1.it
authors: Alessandro
authors: A
authors: Pacella
authors: Giovanni B
authors: GB
authors: Andreozzi
authors: Jeanine
authors: J
authors: Fournier
authors: Lorenzo
authors: L
authors: Stievano
authors: Federica
authors: F
authors: Giantomassi
authors: Guendalina
authors: G
authors: Lucarini
authors: Maria Rita
authors: MR
authors: Rippo
authors: Armanda
authors: A
authors: Pugnaloni
mesh_terms: D017636:Asbestos, Amphibole / Q000737:chemistry* / Q000633:toxicity*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005296:Ferrous Compounds / Q000737:chemistry*; D006801:Humans; D013329:Structure-Activity Relationship; D013499:Surface Properties
chemical_list: D017636:Asbestos, Amphibole; D005296:Ferrous Compounds