title: Thymidine kinase and cancer monitoring.
abstract: Thymidine kinases (TK) have a key function in the synthesis of DNA. Two isoenzymes have been characterized: TK1 is cell cycle-dependent and present in the cytoplasm whereas TK2--located in mitochondria--is cell cycle-independent. The diagnostic and prognostic role of TK1 has recently been investigated. TK1 might be helpful for screening and monitoring of human malignancies. TK1 may also serve as a prognostic factor for progression. Herein, we summarize the status of TK1 for cancer monitoring and point out its use as a proliferation marker. A comprehensive overview about the association of TK-1 with various entities is given.
authors: Department of Urology, Eberhard-Karls University, Tubingen, Germany.
authors: Stefan
authors: S
authors: Aufderklamm
authors: Tilman
authors: T
authors: Todenhöfer
authors: Georgios
authors: G
authors: Gakis
authors: Stephan
authors: S
authors: Kruck
authors: Joerg
authors: J
authors: Hennenlotter
authors: Arnulf
authors: A
authors: Stenzl
authors: Christian
authors: C
authors: Schwentner
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D002453:Cell Cycle / Q000502:physiology; D006801:Humans; D007527:Isoenzymes; D009369:Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D011379:Prognosis; D013937:Thymidine Kinase / Q000235:genetics / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D007527:Isoenzymes; D013937:Thymidine Kinase; C092717:thymidine kinase 1