title: Neurotransmitter corelease: mechanism and physiological role.
abstract: Neurotransmitter identity is a defining feature of all neurons because it constrains the type of information they convey, but many neurons release multiple transmitters. Although the physiological role for corelease has remained poorly understood, the vesicular uptake of one transmitter can regulate filling with the other by influencing expression of the H(+) electrochemical driving force. In addition, the sorting of vesicular neurotransmitter transporters and other synaptic vesicle proteins into different vesicle pools suggests the potential for distinct modes of release. Corelease thus serves multiple roles in synaptic transmission.
authors: Departments of Physiology & Neurology, University of California, San Francisco, California 94158-2517, USA. thomas.hnasko@ucsf.edu
authors: Thomas S
authors: TS
authors: Hnasko
authors: Robert H
authors: RH
authors: Edwards
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D000838:Anions / Q000378:metabolism; D015306:Biogenic Monoamines / Q000502:physiology; D002412:Cations / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism / Q000502:physiology; D018698:Glutamic Acid / Q000378:metabolism / Q000502:physiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D018377:Neurotransmitter Agents / Q000378:metabolism / Q000502:physiology*; D011522:Protons; D009435:Synaptic Transmission / Q000502:physiology*; D013572:Synaptic Vesicles / Q000378:metabolism / Q000502:physiology; D050481:Vesicular Neurotransmitter Transport Proteins / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D000838:Anions; D015306:Biogenic Monoamines; D002412:Cations; D002712:Chlorides; D018377:Neurotransmitter Agents; D011522:Protons; D050481:Vesicular Neurotransmitter Transport Proteins; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D000109:Acetylcholine