title: Polysaccharide microarrays: application to the identification of heparan sulphate mimetics.
abstract: The interaction of polysaccharides with proteins modulates or triggers many biological effects. In particular, heparan sulphate proteoglycans (HSPGs) have multiple regulatory interactions with growth factors, enzymes, enzyme inhibitors, and some components of the extracellular matrix. The important role played by HSPGs has motivated the synthesis and selection of HSPG mimetics for modulating the biological activity of HS-binding proteins. We present hereinafter an efficient polysaccharide microarray method that allows the screening of HS-mimetic libraries towards HS-binding growth factors, a major class of polypeptides whose inhibition or potentiation is of high medical interest.
authors: CNRS UMR 8161, Université Lille Nord de France, Institut Pasteur de Lille, IFR 142 Molecular and Cellular Medicine, Lille, France.
authors: Julien
authors: J
authors: Dheur
authors: Nabil
authors: N
authors: Dendane
authors: Rémi
authors: R
authors: Desmet
authors: Fatima
authors: F
authors: Dahmani
authors: Gauthier
authors: G
authors: Goormachtigh
authors: Jérome
authors: J
authors: Vicogne
authors: Véronique
authors: V
authors: Fafeur
authors: Oleg
authors: O
authors: Melnyk
mesh_terms: D019812:Heparan Sulfate Proteoglycans / Q000737:chemistry; D006497:Heparan Sulfate / Q000737:chemistry*; D046228:Microarray Analysis / Q000379:methods*; D011506:Proteins / Q000737:chemistry
chemical_list: D019812:Heparan Sulfate Proteoglycans; D006497:Heparan Sulfate; D011506:Proteins