title: Under pressure: the search for the essential mechanisms of hypertension.
abstract: High blood pressure, or hypertension, is a very common disorder with a substantial impact on public health because of its associated complications. Despite the high prevalence of essential hypertension and years of research, the basic causes remain obscure. Here I review recent advances in understanding the pathophysiology of hypertension. I present a general overview of the field and, by necessity, use broad strokes to portray recent progress and place it in context. For this purpose, I use illustrative examples from the large number of important developments in hypertension research over the last five years. The intent of this review is to provide a sense of where the field is progressing, with an emphasis on work that sheds light on pathogenic mechanisms and that is therefore likely to inform new translational advances.
authors: Division of Nephrology, Department of Medicine, Cardiovascular Research Center, Duke University, Durham, North Carolina, USA. tcoffman@duke.edu
authors: Thomas M
authors: TM
authors: Coffman
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000235:genetics / Q000503:physiopathology*; D007668:Kidney / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D012867:Skin / Q000378:metabolism; D012964:Sodium / Q000378:metabolism
chemical_list: D012964:Sodium