title: Effects of duration of treatment and dosage of eicosapentaenoic acid and stearidonic acid on red blood cell eicosapentaenoic acid content.
abstract: OBJECTIVE
  The purpose of this randomized, controlled, parallel group study was to characterize the relationships between dosages of stearidonic acid (SDA) and eicosapentaenoic acid (EPA), and incorporation of EPA into red blood cell (RBC) membranes over time.
  
  
  METHODS
  Healthy subjects (n=131) received capsules with placebo (safflower oil), SDA (0.43, 1.3, 2.6, or 5.2 g/d) or EPA (0.44, 1.3, or 2.7 g/d) for 12 weeks. RBC fatty acids were analyzed biweekly.
  
  
  RESULTS
  RBC %EPA increased in all EPA and SDA groups (p<0.02 vs. control) except the 0.43 g/d SDA group (p=0.187). For theoretical intakes of EPA of 0.25, 0.5, and 0.89 g/d, the amounts of SDA needed to achieve equivalent RBC EPA enrichment were 0.61, 1.89, and 5.32 g/d (conversion efficiencies of 41%, 26%, and 17%), respectively.
  
  
  CONCLUSIONS
  SDA increased RBC %EPA in a dosage and time-dependent manner at intakes as low as 1.3 g/d.
authors: Solae LLC, 4300 Duncan Avenue, St. Louis, MO 63110, USA. EKrul@solae.com
authors: E S
authors: ES
authors: Krul
authors: S L
authors: SL
authors: Lemke
authors: R
authors: R
authors: Mukherjea
authors: M L
authors: ML
authors: Taylor
authors: D A
authors: DA
authors: Goldstein
authors: H
authors: H
authors: Su
authors: P
authors: P
authors: Liu
authors: A
authors: A
authors: Lawless
authors: W S
authors: WS
authors: Harris
authors: K C
authors: KC
authors: Maki
mesh_terms: D000328:Adult; D002214:Capsules; D003967:Diarrhea / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D015118:Eicosapentaenoic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D004910:Erythrocyte Membrane / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D016037:Single-Blind Method; D013997:Time Factors
chemical_list: D002214:Capsules; D015525:Fatty Acids, Omega-3; D015118:Eicosapentaenoic Acid; C062895:stearidonic acid