title: Chronic sciatic nerve injury impairs the local cutaneous neurovascular interaction in rats.
abstract: Most studies of chronic nerve compression focus on large nerve function in painful conditions, and only few studies have assessed potential changes in the function of small nerve fibers during chronic nerve compression and recovery from compression. Cutaneous pressure-induced vasodilation is a neurovascular phenomenon that relies on small neuropeptidergic fibers controlling the cutaneous microvasculature. We aimed to characterize potential changes in function of these small fibers and/or in cutaneous microvascular function following short-term (1-month) and long-term (6-month) nerve compression and after release of compression (ie, potential recovery of function). A compressive tube was left on one sciatic nerve for 1 or 6 months and then removed for 1-month recovery in Wistar rats. Cutaneous vasodilator responses were measured by laser Doppler flowmetry in hind limb skin innervated by the injured nerve to assess neurovascular function. Nociceptive thermal and low mechanical thresholds were evaluated to assess small and large nerve fiber functions, respectively. Pressure-induced vasodilation was impaired following nerve compression and restored following nerve release; both impairment and restoration were strongly related to duration of compression. Small and large nerve fiber functions were less closely related to duration of compression. Our data therefore suggest that cutaneous pressure-induced vasodilation provides a non-invasive and mechanistic test of neurovascular function that gives direct information regarding extent and severity of damage during chronic nerve compression and recovery, and may ultimately provide a clinically useful tool in the evaluation of nerve injury such as carpal tunnel syndrome.
authors: Institut de biologie et chimie des protéines - FRE CNRS 3310, 69 367 Lyon, France University of Lyon 1, 69 367 Lyon, France UMR INSERM 1052 - CNRS 5286, 69 008 Lyon, France Laboratory of Ergonomics and Epidemiology in Health at Work, University of Angers, University Hospital, 49 933 Angers, France.
authors: Julien
authors: J
authors: Pelletier
authors: Bérengère
authors: B
authors: Fromy
authors: Gérard
authors: G
authors: Morel
authors: Yves
authors: Y
authors: Roquelaure
authors: Jean Louis
authors: JL
authors: Saumet
authors: Dominique
authors: D
authors: Sigaudo-Roussel
mesh_terms: D000818:Animals; D008297:Male; D009408:Nerve Compression Syndromes / Q000503:physiopathology*; D010147:Pain Measurement; D010525:Peripheral Nerves / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000293:injuries* / Q000503:physiopathology; D020426:Sciatic Neuropathy / Q000503:physiopathology*; D012867:Skin / Q000098:blood supply* / Q000294:innervation* / Q000503:physiopathology