title: Nodal anaplastic large-cell lymphoma ALK-1- with CD30+ cutaneous lymphoproliferation treated with mistletoe: spontaneous remission or treatment response?
abstract: A 12-year old girl presented with general weakness and weight loss, a localised cervical lymph node enlargement and cutaneous lesions compatible with lymphomatoid papulosis (LyP). Biopsies from lymph node and skin revealed a histological diagnosis of nodal large cell ALK-1- anaplastic lymphoma (ALCL) with a synchronous CD30+ cutaneous lymphoproliferation consistent with lymphomatoid papulosis (LyP). The girl was treated with mistletoe (MT) as monotherapy. Within 1 week after initiation of MT-treatment the skin lesions and lymph node enlargement improved. Under continuing MT-therapy 30 months after diagnosis the patient is still in complete remission. It is not possible to know whether this was a rare case of spontaneous remission of the nodal and skin-manifestations of this CD30+ T-cell lymphoproliferation or whether the observed effect was a specific therapeutic response to MT-treatment.
authors: Department of Integrative Pediatric und Adolescent Medicine, Gemeinschaftskrankenhaus, Herdecke, Germany. gkameda@hotmail.com
authors: G
authors: G
authors: Kameda
authors: W
authors: W
authors: Kempf
authors: I
authors: I
authors: Oschlies
authors: K
authors: K
authors: Michael
authors: G
authors: G
authors: Seifert
authors: A
authors: A
authors: Längler
mesh_terms: D030301:Activin Receptors, Type II / Q000032:analysis*; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D017728:Lymphoma, Large-Cell, Anaplastic / Q000175:diagnosis / Q000188:drug therapy*; D017731:Lymphomatoid Papulosis / Q000188:drug therapy*; D014784:Mistletoe; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D012074:Remission Induction; D012878:Skin Neoplasms / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D010936:Plant Extracts; C425364:ACVRL1 protein, human; D030301:Activin Receptors, Type II