title: An update on the pathology and clinical management of gouty arthritis.
abstract: Gouty arthritis is an inflammatory condition associated with debilitating clinical symptoms, functional impairments, and a substantial impact on quality of life. This condition is initially triggered by the deposition of monosodium urate crystals into the joint space. This causes an inflammatory cascade resulting in the secretion of several proinflammatory cytokines and neutrophil recruitment into the joint. While generally effective, currently available agents are associated with a number of adverse events and contraindications that complicate their use. Based on our increased understanding of the inflammatory pathogenesis of gouty arthritis, several new agents are under development that may provide increased efficacy and reduced toxicity.
authors: Division of Rheumatology, Department of Medicine, The University of Texas Medical Branch (UTMB), 301 University Blvd, Route 0565, Galveston, TX 77555-0565, USA. ebgonzal@utmb.edu
authors: Emilio B
authors: EB
authors: Gonzalez
mesh_terms: D000368:Aged; D015210:Arthritis, Gouty / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D006074:Gout Suppressants / Q000627:therapeutic use*; D006801:Humans; D007596:Joints / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012219:Rheumatology / Q000639:trends*; D014527:Uric Acid / Q000378:metabolism
chemical_list: D006074:Gout Suppressants; D014527:Uric Acid