title: Molecular-genetic mapping of zebrafish mutants with variable phenotypic penetrance.
abstract: Forward genetic screens in vertebrates are powerful tools to generate models relevant to human diseases, including neuropsychiatric disorders. Variability in phenotypic penetrance and expressivity is common in these disorders and behavioral mutant models, making their molecular-genetic mapping a formidable task. Using a 'phenotyping by segregation' strategy, we molecularly map the hypersensitive zebrafish houdini mutant despite its variable phenotypic penetrance, providing a generally applicable strategy to map zebrafish mutants with subtle phenotypes.
authors: Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.
authors: Roshan A
authors: RA
authors: Jain
authors: Marc A
authors: MA
authors: Wolman
authors: Lauren A
authors: LA
authors: Schmidt
authors: Harold A
authors: HA
authors: Burgess
authors: Michael
authors: M
authors: Granato
mesh_terms: D000818:Animals; D009154:Mutation; D010641:Phenotype; D015027:Zebrafish / Q000235:genetics*