title: Multispectral optoacoustic tomography by means of normalized spectral ratio.
abstract: Quantification of biomarkers using multispectral optoacoustic tomography can be challenging due to photon fluence variations with depth and spatially heterogeneous tissue optical properties. Herein we introduce a spectral ratio approach that accounts for photon fluence variations. The performance and imaging improvement achieved with the proposed method is showcased both numerically and experimentally in phantoms and mice.
authors: Institute for Biological and Medical Imaging, Technische Universität München and Helmholtz Zentrum München, Ingolstaedter Landstr. 1, 85764 Neuherberg, Germany.
authors: Thomas
authors: T
authors: Jetzfellner
authors: Amir
authors: A
authors: Rosenthal
authors: Andreas
authors: A
authors: Buehler
authors: Karl-Hans
authors: KH
authors: Englmeier
authors: Daniel
authors: D
authors: Razansky
authors: Vasilis
authors: V
authors: Ntziachristos
mesh_terms: D000818:Animals; D051379:Mice; D055620:Optical Phenomena; D019047:Phantoms, Imaging; D061088:Photoacoustic Techniques / Q000379:methods*; D014054:Tomography / Q000379:methods*