title: PET imaging using 64Cu-labeled sulfophthalocyanines: synthesis and biodistribution.
abstract: Sulfonated metallo phthalocyanines (MPcS(n)) are second generation photosensitizers advanced for photodynamic therapy of various medical applications. A series of ZnPcS(n) was demetallated and subsequently converted to the corresponding [(64)Cu]CuPcS(n) in 40-50% isolated yields and >98% radiochemical purities. Tumor-bearing mice were injected with the (64)Cu-labeled products and subjected to 3-h dynamic PET imaging studies. Biodistribution patterns showed characteristic differences between the various derivatives. Tumor uptake was detected only for the amphiphilic derivatives [(64)Cu]CuPcS(2) and [(64)Cu]CuPcS(3)C(6) (1-1.5%ID/g). The biological data suggest that PET imaging with [(64)Cu]CuPc can be used to establish structure-PDT efficacy relationships for Pc-based photosensitizers.
authors: Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, 3001, 12th Avenue North, Sherbrooke, Québec, Canada J1H 5N4.
authors: Elena R
authors: ER
authors: Ranyuk
authors: Nicole
authors: N
authors: Cauchon
authors: Hasrat
authors: H
authors: Ali
authors: Roger
authors: R
authors: Lecomte
authors: Brigitte
authors: B
authors: Guérin
authors: Johan E
authors: JE
authors: van Lier
mesh_terms: D000818:Animals; D003301:Copper Radioisotopes / Q000737:chemistry; D007211:Indoles / Q000737:chemistry* / Q000493:pharmacokinetics; D054833:Isoindoles; D007553:Isotope Labeling; D051379:Mice; D009369:Neoplasms / Q000000981:diagnostic imaging; D009942:Organometallic Compounds / Q000737:chemistry; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: D003301:Copper Radioisotopes; D007211:Indoles; D054833:Isoindoles; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; D019275:Radiopharmaceuticals; C063072:zinc(II) phthalocyanine trisulfonic acid; C013647:phthalocyanine