title: Serine protease autotransporters of enterobacteriaceae (SPATEs): biogenesis and function.
abstract: Serine Protease Autotransporters of Enterobacteriaceae (SPATEs) constitute a large family of proteases secreted by Escherichia coli and Shigella. SPATEs exhibit two distinct proteolytic activities. First, a C-terminal catalytic site triggers an intra-molecular cleavage that releases the N-terminal portion of these proteins in the extracellular medium. Second, the secreted N-terminal domains of SPATEs are themselves proteases; each contains a canonical serine-protease catalytic site. Some of these secreted proteases are toxins, eliciting various effects on mammalian cells. Here, we discuss the biogenesis of SPATEs and their function as toxins.
authors: Department of Biology, The Catholic University of America, 620 Michigan Avenue N.E., Washington, DC, 20064, USA. dautin@cua.edu
authors: Nathalie
authors: N
authors: Dautin
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D001427:Bacterial Toxins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004926:Escherichia coli; D006801:Humans; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D057057:Serine Proteases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D012763:Shigella flexneri
chemical_list: D001426:Bacterial Proteins; D001427:Bacterial Toxins; D057057:Serine Proteases