title: Strontium promotes cell proliferation and suppresses IL-6 expression in human PDL cells.
abstract: This study was designed to investigate the effect of strontium on human PDL cells in vitro. Strontium is used to treat osteoporosis because of its bone formation promoting effect on osteoblast cells. This investigation presents evidence that strontium promotes PDL cell proliferation. Simultaneously, strontium suppresses the expression of the inflammation-promoting cytokine IL-6. The observed effect of strontium on PDL cells supports its use it in guided dental tissue regeneration.
authors: University Medical Center Regensburg, Department of Orthodontics, Germany. piero.roemer@gmx.de
authors: Piero
authors: P
authors: Römer
authors: Benjamin
authors: B
authors: Desaga
authors: Peter
authors: P
authors: Proff
authors: Andreas
authors: A
authors: Faltermeier
authors: Claudia
authors: C
authors: Reicheneder
mesh_terms: D000293:Adolescent; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D005260:Female; D016557:Guided Tissue Regeneration, Periodontal; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis*; D010006:Osteoblasts / Q000187:drug effects; D010513:Periodontal Ligament / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism*; D012313:RNA / Q000096:biosynthesis / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D013324:Strontium / Q000494:pharmacology*; D000093242:Interleukin-6 Inhibitors
chemical_list: D015850:Interleukin-6; D012313:RNA; D013324:Strontium; D000093242:Interleukin-6 Inhibitors