title: [Study of Dj-1 protein in tissue specimens, cultured cells and serum of prostate cancer patients].
abstract: Two isoforms of Dj-1 protein were identified using a proteomic study in tissue specimens from two groups of patients with confirmed benign prostate hyperplasia (BPH) and prostate cancer (PCa). Dj-1 was also found in the cell lines PC-3, DU-145, LNCaP, BPH-1, and the lowest level of Dj-1 was found in BPH-1. Immunochemical study (ELISA) of serum levels of Dj-1, Bcl-2, IGF-1 and IGFBP-3 proteins revealed statistically significant distinctions between two groups of patients (p=0,004, Mann-Whitney test) only for Dj-1. Taken together, these data suggest that Dj-1 protein is a perspective biomarker candidate for PCa.
authors: K V
authors: KV
authors: Lisitskaia
authors: L S
authors: LS
authors: Eremina
authors: A V
authors: AV
authors: Ivanov
authors: M A
authors: MA
authors: Kovaleva
authors: V E
authors: VE
authors: Okhrits
authors: I Iu
authors: IIu
authors: Toropygin
authors: L I
authors: LI
authors: Kovalev
authors: S S
authors: SS
authors: Shishkin
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D045744:Cell Line, Tumor; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D015513:Oncogene Proteins / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood*; D000071617:Protein Deglycase DJ-1; D040901:Proteomics
chemical_list: D014408:Biomarkers, Tumor; D047908:Intracellular Signaling Peptides and Proteins; D015513:Oncogene Proteins; C105131:PARK7 protein, human; D000071617:Protein Deglycase DJ-1