title: [Experimental research on the effects of a Cetraria islandica extract on oxidative stress in laboratory animals].
abstract: OBJECTIVE
  Experimental researches on the effects of a Cetraria islandica extract, with or without magnesium association, on oxidative stress in rats.
  
  
  METHODS
  The experiments were carried out on Wistar rats, treated intraperitoneally for 14 days at single daily dose as follows: Group 1: Saline solution (SS) (0.5 ml/100g bw/day); Group 2: Subcutaneous pellets, SS; Group 3: Levamisole (LEV) (10mg/kbw/day); Group 4: Subcutaneous pellets, LEV; Group 5: Prednison (PDN) (5mg/kbw/day); Group 6: Subcutaneous pellets, PDN; Group 7: MgSO4 (5mg/kbw/day); Group 8: Subcutaneous pellets, MgSO4; Group 9: C. islandica (Ci) extract (21.56mg/kbw/day); Group 10: Subcutaneous pellets, Ci; Group 11: Ci+MgSO4; Group 12: Subcutaneous pellets, Ci+MgSO4. At the end of the experiment blood samples were collected for assessing the following oxidative stress parameters: malonaldehyde, catalase, glutathione peroxidase, glutathione levels.
  
  
  RESULTS
  In the rats with or without experimentally-induced granuloma, repeated administration of Ci for 14 days resulted in a decrease of malonaldehyde, catalase, glutathione peroxidase activity, and an increase in glutathione levels. The association of magnesium augmented the antioxidant effect of Ci in this experimental model.
  
  
  CONCLUSIONS
  In our study experimental conditions C. islandica extract determined adaptogenic-antistress effects, confirmed by its actions on oxidative stress parameters.
authors: Universitatea de Medicină şi Farmacie "Gr. T. Popa" Iaşi, Facultatea de Medicină.
authors: Irina
authors: I
authors: Cernescu
authors: Liliana
authors: L
authors: Tarţău
authors: Antonela
authors: A
authors: Macavei
authors: Cătălina-Elena
authors: CE
authors: Lupuşoru
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D002374:Catalase / Q000097:blood / Q000187:drug effects; D005978:Glutathione / Q000097:blood / Q000187:drug effects; D005979:Glutathione Peroxidase / Q000097:blood / Q000187:drug effects; D008011:Lichens; D008274:Magnesium / Q000008:administration & dosage; D008315:Malondialdehyde / Q000097:blood; D023421:Models, Animal; D018384:Oxidative Stress / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D005978:Glutathione; D008274:Magnesium