title: HTLV-2 APH-2 expression is correlated with proviral load but APH-2 does not promote lymphocytosis.
abstract: We recently discovered the antisense protein of human T-cell leukemia virus (HTLV) type 2 (APH-2), whose messenger RNA is encoded by the antisense strand of the HTLV-2 genome. We quantified proviral load, level of tax, and APH-2 in a series of blood samples obtained from a cohort of HTLV-2 carriers. We determined whether APH-2 promotes cell proliferation. APH-2 was detectable in most samples tested and was correlated with proviral load. APH-2 levels were not correlated with lymphocyte count in vivo, consistent with the inability of APH-2 to promote cell proliferation in vitro. APH-2 does not promote cell proliferation and does not cause lymphocytosis.
authors: Equipe Oncogenèse Rétrovirale, INSERM-U758 Virologie Humaine, France.
authors: Estelle
authors: E
authors: Douceron
authors: Zhanna
authors: Z
authors: Kaidarova
authors: Paola
authors: P
authors: Miyazato
authors: Masao
authors: M
authors: Matsuoka
authors: Edward L
authors: EL
authors: Murphy
authors: Renaud
authors: R
authors: Mahieux
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D058345:Asymptomatic Infections; D015331:Cohort Studies; D005260:Female; D016356:Gene Products, tax / Q000097:blood; D015491:HTLV-II Infections / Q000097:blood / Q000150:complications / Q000821:virology*; D015367:Human T-lymphotropic virus 2 / Q000378:metabolism*; D006801:Humans; D016014:Linear Models; D008218:Lymphocytosis / Q000821:virology*; D008297:Male; D008875:Middle Aged; D011533:Proviruses / Q000378:metabolism*; D012191:Retroviridae Proteins / Q000097:blood*; D019562:Viral Load
chemical_list: D016356:Gene Products, tax; D012191:Retroviridae Proteins; C514971:tax protein, Human T-lymphotrophic virus 2