title: Gene-environment interactions of novel variants associated with head and neck cancer.
abstract: BACKGROUND
  A genome-wide association study for upper aerodigestive tract cancers identified 19 candidate single-nucleotide polymorphisms (SNPs). We used these SNPs to investigate the potential gene-gene and gene-environment interactions in head and neck squamous cell carcinoma (HNSCC) risk.
  
  
  METHODS
  The 19 variants were genotyped using Taqman assays among 575 cases and 676 controls in our population-based case-control study.
  
  
  RESULTS
  A restricted cubic spline model suggested both ADH1B and HEL308 modified the association between smoking pack-years and HNSCC. Classification and regression tree analysis demonstrated a higher-order interaction between smoking status, ADH1B, FLJ13089, and FLJ35784 in HNSCC risk. Compared with ever smokers carrying ADH1B T/C+T/T genotypes, smokers carrying ADH1B C/C genotype and FLJ13089 A/G+A/A genotypes had the highest risk of HNSCC (odds ratio = 1.84).
  
  
  CONCLUSIONS
  Our results suggest that the risk associated with these variants may be specifically important among specific exposure groups.
authors: Department of Community Health, Brown University, Providence, Rhode Island, USA.
authors: Caihua
authors: C
authors: Liang
authors: Carmen J
authors: CJ
authors: Marsit
authors: E Andres
authors: EA
authors: Houseman
authors: Rondi
authors: R
authors: Butler
authors: Heather H
authors: HH
authors: Nelson
authors: Michael D
authors: MD
authors: McClean
authors: Karl T
authors: KT
authors: Kelsey
mesh_terms: D000426:Alcohol Dehydrogenase / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D016022:Case-Control Studies; D004265:DNA Helicases / Q000235:genetics; D005260:Female; D059647:Gene-Environment Interaction; D005838:Genotype; D006258:Head and Neck Neoplasms / Q000235:genetics*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D012907:Smoking / Q000009:adverse effects
chemical_list: C489332:ADH1B protein, human; D000426:Alcohol Dehydrogenase; D004265:DNA Helicases; C451406:HELQ protein, human