title: Correlation of N-terminal fragment of B-type natriuretic peptide levels with clinical, laboratory, and echocardiographic abnormalities in children with sickle cell disease.
abstract: OBJECTIVE
  To determine whether the N-terminal fragment of B-type natriuretic peptide (NTproBNP) was a biomarker of clinical, laboratory, and echocardiographic abnormalities in children with homozygous sickle cell disease.
  
  
  METHODS
  We conducted a single-center retrospective study that consisted of analysis of data from November 2007 to December 2010. We correlated serum NTproBNP with clinical and laboratory findings, echocardiographic data, and New York Heart Association (NYHA) functional class.
  
  
  RESULTS
  NTproBNP levels from 42 children (median age, 9 years; 52% female) had significant correlations with hemoglobin (r = -0.63, P < .05), and echocardiographic measurements including tricuspid regurgitant velocity (r = 0.46, P < .05), lateral E' (r = -0.52, P < .05), and lateral E/E' ratio (r = 0.60, P < .05), suggesting diastolic dysfunction. In addition, NTproBNP levels increased from NYHA functional class I to class III and had a significant linear correlation with the NYHA functional class (r = 0.69, P < .05).
  
  
  CONCLUSIONS
  NTproBNP correlated with low hemoglobin and tissue Doppler data as indicators of diastolic dysfunction. Elevated NTproBNP may be a prognostic biomarker for the presence of diastolic dysfunction related to anemia in children with sickle cell disease.
authors: Department of Pediatrics, Section of Pediatric Cardiology, University of Colorado Denver School of Medicine, Children's Hospital of Colorado, Aurora, CO 80045, USA. tekeshin0621@msn.com
authors: Shinichi
authors: S
authors: Takatsuki
authors: David Dunbar
authors: DD
authors: Ivy
authors: Rachelle
authors: R
authors: Nuss
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D001783:Blood Flow Velocity; D002648:Child; D002675:Child, Preschool; D004452:Echocardiography; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011379:Prognosis; D014262:Tricuspid Valve Insufficiency / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006454:Hemoglobins; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain