title: Position paper of the Italian Society for the study of Dementias (SINDEM) on the proposal of a new lexicon on Alzheimer disease.
abstract: A panel of Italian neurologists of the Italian Society for the study of Dementias (SINDEM) discussed the recently proposed new lexicon for Alzheimer disease (AD) and the related diagnostic criteria for the different phases of the disease (Preclinical AD, prodromal AD and Alzheimer's dementia) (Dubois et al. in Lancet Neurol 6:734-746, 2007; in Lancet Neurol 9:1118-1127, 2010). The aim of this discussion was to reach a consensus, among the Italian neurologists involved in the study and care of persons with dementia, in particular in reference to the potential use of the proposed diagnostic criteria in clinical practice. After having critically revised the scientific evidence related to the new lexicon and to the new proposed diagnostic criteria, the panel concluded that the proposed new diagnostic criteria and the new proposed lexicon for AD are conceptually attractive. However, the evidence about the instrumental and laboratory markers for the diagnosis of the preclinical and asymptomatic states of the disease are, until to now, insufficient to support the routine clinical use of these investigations.
authors: Institute of Biomedical Technologies, National Research Council, Segrate (Mi), Foundation IRCCS "Santa Lucia", Rome, Italy.
authors: Massimo
authors: M
authors: Musicco
authors: Alessandro
authors: A
authors: Padovani
authors: Sandro
authors: S
authors: Sorbi
authors: Elio
authors: E
authors: Scarpini
authors: Paolo
authors: P
authors: Caffarra
authors: Stefano
authors: S
authors: Cappa
authors: Francesca
authors: F
authors: Clerici
authors: Massimo
authors: M
authors: Tabaton
authors: Carlo
authors: C
authors: Caltagirone
authors: Vincenzo
authors: V
authors: Bonavita
authors: Amalia C
authors: AC
authors: Bruni
authors: Giuseppe
authors: G
authors: Bruno
authors: Antonio
authors: A
authors: Federico
authors: Carlo
authors: C
authors: Ferrarese
authors: Camillo
authors: C
authors: Marra
authors: Benedetta
authors: B
authors: Nacmias
authors: Lucilla
authors: L
authors: Parnetti
authors: Carla
authors: C
authors: Pettenati
authors: Giuseppe
authors: G
authors: Sorrentino
authors: Fabrizio
authors: F
authors: Tagliavini
authors: Claudio
authors: C
authors: Mariani
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis*; D003704:Dementia / Q000175:diagnosis*; D003937:Diagnosis, Differential; D006801:Humans